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Search of human proteins with 30795202
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens]
(1066 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens] 2117 0.0
gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens] 2112 0.0
gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens] 1999 0.0
gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens] 1708 0.0
gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens] 1165 0.0
gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens] 1165 0.0
gi|153085395 histone deacetylase 4 [Homo sapiens] 1134 0.0
gi|7662280 histone deacetylase 9 isoform 3 [Homo sapiens] 1126 0.0
gi|169234807 histone deacetylase 7 isoform a [Homo sapiens] 674 0.0
gi|148539870 histone deacetylase 7 isoform d [Homo sapiens] 653 0.0
gi|13128864 histone deacetylase 6 [Homo sapiens] 282 1e-75
gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens] 236 1e-61
gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens] 202 1e-51
gi|116284376 histone deacetylase 2 [Homo sapiens] 111 3e-24
gi|13128860 histone deacetylase 1 [Homo sapiens] 110 7e-24
gi|8923769 histone deacetylase 8 [Homo sapiens] 107 5e-23
gi|13128862 histone deacetylase 3 [Homo sapiens] 90 1e-17
gi|217272877 histone deacetylase 11 isoform 1 [Homo sapiens] 67 7e-11
gi|209862883 histone deacetylase 11 isoform 2 [Homo sapiens] 67 7e-11
gi|221139761 zinc finger protein 853 [Homo sapiens] 59 2e-08
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 56 2e-07
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 56 2e-07
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 56 2e-07
gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens] 56 2e-07
gi|17017963 forkhead box P2 isoform I [Homo sapiens] 55 4e-07
gi|148746195 trichohyalin [Homo sapiens] 54 8e-07
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 54 8e-07
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 52 3e-06
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 52 3e-06
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 52 3e-06
>gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens]
Length = 1066
Score = 2117 bits (5486), Expect = 0.0
Identities = 1066/1066 (100%), Positives = 1066/1066 (100%)
Query: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60
MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ
Sbjct: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60
Query: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR 120
KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR
Sbjct: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR 120
Query: 121 EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA 180
EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA
Sbjct: 121 EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA 180
Query: 181 HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS 240
HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS
Sbjct: 181 HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS 240
Query: 241 PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA 300
PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA
Sbjct: 241 PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA 300
Query: 301 EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ 360
EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ
Sbjct: 301 EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ 360
Query: 361 GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP 420
GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP
Sbjct: 361 GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP 420
Query: 421 QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ 480
QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ
Sbjct: 421 QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ 480
Query: 481 QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG 540
QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG
Sbjct: 481 QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG 540
Query: 541 QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGL 600
QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGL
Sbjct: 541 QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGL 600
Query: 601 EKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGR 660
EKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGR
Sbjct: 601 EKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGR 660
Query: 661 IQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGD 720
IQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGD
Sbjct: 661 IQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGD 720
Query: 721 DSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPP 780
DSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPP
Sbjct: 721 DSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPP 780
Query: 781 GHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI 840
GHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI
Sbjct: 781 GHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI 840
Query: 841 SLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAK 900
SLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAK
Sbjct: 841 SLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAK 900
Query: 901 EFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTA 960
EFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTA
Sbjct: 901 EFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTA 960
Query: 961 ICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVPRGC 1020
ICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVPRGC
Sbjct: 961 ICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVPRGC 1020
Query: 1021 ALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL 1066
ALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL
Sbjct: 1021 ALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL 1066
>gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens]
Length = 1069
Score = 2112 bits (5472), Expect = 0.0
Identities = 1066/1069 (99%), Positives = 1066/1069 (99%), Gaps = 3/1069 (0%)
Query: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60
MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ
Sbjct: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60
Query: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIK---ELLAIKQQQELLEKEQKLEQQRQEQEVER 117
KQLLIAEFQKQHENLTRQHQAQLQEHIK ELLAIKQQQELLEKEQKLEQQRQEQEVER
Sbjct: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVER 120
Query: 118 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 177
HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY
Sbjct: 121 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 180
Query: 178 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 237
TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER
Sbjct: 181 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 240
Query: 238 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 297
RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT
Sbjct: 241 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 300
Query: 298 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 357
PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT
Sbjct: 301 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 360
Query: 358 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 417
LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP
Sbjct: 361 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 420
Query: 418 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 477
LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ
Sbjct: 421 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 480
Query: 478 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 537
YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD
Sbjct: 481 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 540
Query: 538 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM 597
TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM
Sbjct: 541 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM 600
Query: 598 DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH 657
DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH
Sbjct: 601 DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH 660
Query: 658 AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL 717
AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL
Sbjct: 661 AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL 720
Query: 718 LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV 777
LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV
Sbjct: 721 LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV 780
Query: 778 RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI 837
RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI
Sbjct: 781 RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI 840
Query: 838 LYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKP 897
LYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKP
Sbjct: 841 LYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKP 900
Query: 898 VAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHD 957
VAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHD
Sbjct: 901 VAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHD 960
Query: 958 LTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVP 1017
LTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVP
Sbjct: 961 LTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVP 1020
Query: 1018 RGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL 1066
RGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL
Sbjct: 1021 RGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL 1069
>gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens]
Length = 1011
Score = 1999 bits (5179), Expect = 0.0
Identities = 1005/1005 (100%), Positives = 1005/1005 (100%)
Query: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60
MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ
Sbjct: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60
Query: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR 120
KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR
Sbjct: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR 120
Query: 121 EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA 180
EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA
Sbjct: 121 EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA 180
Query: 181 HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS 240
HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS
Sbjct: 181 HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS 240
Query: 241 PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA 300
PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA
Sbjct: 241 PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA 300
Query: 301 EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ 360
EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ
Sbjct: 301 EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ 360
Query: 361 GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP 420
GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP
Sbjct: 361 GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP 420
Query: 421 QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ 480
QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ
Sbjct: 421 QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ 480
Query: 481 QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG 540
QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG
Sbjct: 481 QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG 540
Query: 541 QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGL 600
QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGL
Sbjct: 541 QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGL 600
Query: 601 EKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGR 660
EKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGR
Sbjct: 601 EKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGR 660
Query: 661 IQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGD 720
IQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGD
Sbjct: 661 IQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGD 720
Query: 721 DSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPP 780
DSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPP
Sbjct: 721 DSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPP 780
Query: 781 GHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI 840
GHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI
Sbjct: 781 GHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI 840
Query: 841 SLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAK 900
SLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAK
Sbjct: 841 SLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAK 900
Query: 901 EFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTA 960
EFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTA
Sbjct: 901 EFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTA 960
Query: 961 ICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQS 1005
ICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQS
Sbjct: 961 ICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQS 1005
>gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens]
Length = 879
Score = 1708 bits (4423), Expect = 0.0
Identities = 860/860 (100%), Positives = 860/860 (100%)
Query: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60
MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ
Sbjct: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60
Query: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR 120
KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR
Sbjct: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR 120
Query: 121 EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA 180
EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA
Sbjct: 121 EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA 180
Query: 181 HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS 240
HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS
Sbjct: 181 HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS 240
Query: 241 PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA 300
PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA
Sbjct: 241 PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA 300
Query: 301 EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ 360
EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ
Sbjct: 301 EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ 360
Query: 361 GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP 420
GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP
Sbjct: 361 GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP 420
Query: 421 QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ 480
QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ
Sbjct: 421 QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ 480
Query: 481 QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG 540
QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG
Sbjct: 481 QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG 540
Query: 541 QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGL 600
QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGL
Sbjct: 541 QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGL 600
Query: 601 EKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGR 660
EKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGR
Sbjct: 601 EKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGR 660
Query: 661 IQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGD 720
IQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGD
Sbjct: 661 IQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGD 720
Query: 721 DSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPP 780
DSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPP
Sbjct: 721 DSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPP 780
Query: 781 GHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI 840
GHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI
Sbjct: 781 GHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI 840
Query: 841 SLHRYDEGNFFPGSGAPNEV 860
SLHRYDEGNFFPGSGAPNEV
Sbjct: 841 SLHRYDEGNFFPGSGAPNEV 860
>gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens]
Length = 1123
Score = 1165 bits (3013), Expect = 0.0
Identities = 651/1120 (58%), Positives = 799/1120 (71%), Gaps = 76/1120 (6%)
Query: 1 MHSMISSVDVKSEVPVGLEPI---------SPLDLRTDLRMMMPVVDPVVREKQLQQELL 51
+HS+ +V+VK +P + SP++LR L + VDP +RE+QLQQELL
Sbjct: 26 LHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVELRGAL---VGSVDPTLREQQLQQELL 82
Query: 52 LIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIK---ELLAIKQQQELL--EKEQKL 106
++QQQQ+QKQLL AEFQKQH++LTRQH+ QLQ+H+K E+LA KQQQE+L +++Q+L
Sbjct: 83 ALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQEL 142
Query: 107 EQQRQ-----EQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTP 161
EQQRQ ++E+E+ R EQQL LR K++ +E A+ASTEVK +LQEFLLSKS K+
Sbjct: 143 EQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQEFLLSKS--KEPT 200
Query: 162 TNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSG---TSPSYKYTLPGAQDAKDDFPLRKT 218
G NHS+ +HPK W AHH SLDQSSPP SG T PSYK LPG D++DDFPLRKT
Sbjct: 201 PGGLNHSLPQHPKCW--GAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKT 258
Query: 219 ASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVT-----ESSVSSSSPGS 273
ASEPNLKVRSRLKQKVAERRSSPLLRRKDG V+++FKKR E+T SSV +S+PGS
Sbjct: 259 ASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGS 318
Query: 274 GPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLG 333
GPSSPN+ + T +P P +M+ Q R L + S N SLYTSPSLPNI+LG
Sbjct: 319 GPSSPNSSHSTIAENGFTGSVPNIP--TEMLPQHRALPLDSSPNQFSLYTSPSLPNISLG 376
Query: 334 LPAVP----SQLNASNSLKEKQKCETQ---TLRQGVPLPGQYGGSIPASSSHPHVTLEGK 386
L A S L AS L +Q+ E Q +LRQG L G++ + V LEG
Sbjct: 377 LQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGD 436
Query: 387 PPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPL 446
H +LLQH+LL EQ RQQ L+A VPLH QSPL T ER++ +R KLPRHRPL
Sbjct: 437 GSPHGHASLLQHVLLLEQARQQSTLIA--VPLHGQSPLVTGERVATSMRTVGKLPRHRPL 494
Query: 447 NRTQSAPLPQS--TLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEE 504
+RTQS+PLPQS L QLV+QQQHQQFLEKQKQ QQ+ + K+L+K+ E +QP +H EE
Sbjct: 495 SRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQ--QQLQLGKILTKTGELPRQPTTHPEE 552
Query: 505 AEEELQ-------GDQAMQEDRAPSS-GNSTRSD--SSACVDDTLGQVGAVKVKEEPVDS 554
EEEL G+ A+ R S+ ST+ D DD + ++VK+E +S
Sbjct: 553 TEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGES 612
Query: 555 --DEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTHSS 612
+E ++E +G + F L+P L V QAPL+ + H+ + RT SS
Sbjct: 613 GAEEGPDLEEPGAGYKKLFSDAQPLQP-----LQVYQAPLSLATVP----HQALGRTQSS 663
Query: 613 PAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETG 672
PAA D+P++ TG+ YD MLKHQC+CGN+ HPEHAGRIQSIWSRLQETG
Sbjct: 664 PAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETG 723
Query: 673 LLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCG 732
LL+KCERI+GRKA+L+EIQ VHSE+H+LLYGT+PL+ QKLD + LLG SQK ++ LPCG
Sbjct: 724 LLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCG 783
Query: 733 GLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGF 792
G+GVDSDT+WNE+HSS A RMAVGC++ELA KVA+GELKNGFA++RPPGHHAEESTAMGF
Sbjct: 784 GIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGF 843
Query: 793 CFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP 852
CFFNSVAITAK L+ +LN+ K+LIVD D+HHGNGTQQAFY DPS+LYISLHRYD GNFFP
Sbjct: 844 CFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP 903
Query: 853 GSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAG 912
GSGAP EVG G G GYN+N+AWTGG+DPP+GDVEYL AFRT+V P+A EF PD+VLVSAG
Sbjct: 904 GSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAG 963
Query: 913 FDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNAL 972
FDA+EGH PLGGY VTA+CFGHLT+QLMTLA GRVVLALEGGHDLTAICDASEACV+AL
Sbjct: 964 FDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSAL 1023
Query: 973 LGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVPRGCALAGAQL--QEE 1030
L EL+PL E +L Q PN+NAV +L+K+IEIQSK+W V+ A G +L AQ EE
Sbjct: 1024 LSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEE 1083
Query: 1031 TETVSALASLTVDVEQPFA----QEDSRTAGEPMEEEPAL 1066
ETVSA+A L+V EQ A + R A EPME+EPAL
Sbjct: 1084 AETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL 1123
>gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens]
Length = 1122
Score = 1165 bits (3013), Expect = 0.0
Identities = 651/1120 (58%), Positives = 799/1120 (71%), Gaps = 76/1120 (6%)
Query: 1 MHSMISSVDVKSEVPVGLEPI---------SPLDLRTDLRMMMPVVDPVVREKQLQQELL 51
+HS+ +V+VK +P + SP++LR L + VDP +RE+QLQQELL
Sbjct: 25 LHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVELRGAL---VGSVDPTLREQQLQQELL 81
Query: 52 LIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIK---ELLAIKQQQELL--EKEQKL 106
++QQQQ+QKQLL AEFQKQH++LTRQH+ QLQ+H+K E+LA KQQQE+L +++Q+L
Sbjct: 82 ALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQEL 141
Query: 107 EQQRQ-----EQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTP 161
EQQRQ ++E+E+ R EQQL LR K++ +E A+ASTEVK +LQEFLLSKS K+
Sbjct: 142 EQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQEFLLSKS--KEPT 199
Query: 162 TNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSG---TSPSYKYTLPGAQDAKDDFPLRKT 218
G NHS+ +HPK W AHH SLDQSSPP SG T PSYK LPG D++DDFPLRKT
Sbjct: 200 PGGLNHSLPQHPKCW--GAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKT 257
Query: 219 ASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVT-----ESSVSSSSPGS 273
ASEPNLKVRSRLKQKVAERRSSPLLRRKDG V+++FKKR E+T SSV +S+PGS
Sbjct: 258 ASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGS 317
Query: 274 GPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLG 333
GPSSPN+ + T +P P +M+ Q R L + S N SLYTSPSLPNI+LG
Sbjct: 318 GPSSPNSSHSTIAENGFTGSVPNIP--TEMLPQHRALPLDSSPNQFSLYTSPSLPNISLG 375
Query: 334 LPAVP----SQLNASNSLKEKQKCETQ---TLRQGVPLPGQYGGSIPASSSHPHVTLEGK 386
L A S L AS L +Q+ E Q +LRQG L G++ + V LEG
Sbjct: 376 LQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGD 435
Query: 387 PPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPL 446
H +LLQH+LL EQ RQQ L+A VPLH QSPL T ER++ +R KLPRHRPL
Sbjct: 436 GSPHGHASLLQHVLLLEQARQQSTLIA--VPLHGQSPLVTGERVATSMRTVGKLPRHRPL 493
Query: 447 NRTQSAPLPQS--TLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEE 504
+RTQS+PLPQS L QLV+QQQHQQFLEKQKQ QQ+ + K+L+K+ E +QP +H EE
Sbjct: 494 SRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQ--QQLQLGKILTKTGELPRQPTTHPEE 551
Query: 505 AEEELQ-------GDQAMQEDRAPSS-GNSTRSD--SSACVDDTLGQVGAVKVKEEPVDS 554
EEEL G+ A+ R S+ ST+ D DD + ++VK+E +S
Sbjct: 552 TEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGES 611
Query: 555 --DEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTHSS 612
+E ++E +G + F L+P L V QAPL+ + H+ + RT SS
Sbjct: 612 GAEEGPDLEEPGAGYKKLFSDAQPLQP-----LQVYQAPLSLATVP----HQALGRTQSS 662
Query: 613 PAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETG 672
PAA D+P++ TG+ YD MLKHQC+CGN+ HPEHAGRIQSIWSRLQETG
Sbjct: 663 PAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETG 722
Query: 673 LLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCG 732
LL+KCERI+GRKA+L+EIQ VHSE+H+LLYGT+PL+ QKLD + LLG SQK ++ LPCG
Sbjct: 723 LLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCG 782
Query: 733 GLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGF 792
G+GVDSDT+WNE+HSS A RMAVGC++ELA KVA+GELKNGFA++RPPGHHAEESTAMGF
Sbjct: 783 GIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGF 842
Query: 793 CFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP 852
CFFNSVAITAK L+ +LN+ K+LIVD D+HHGNGTQQAFY DPS+LYISLHRYD GNFFP
Sbjct: 843 CFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP 902
Query: 853 GSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAG 912
GSGAP EVG G G GYN+N+AWTGG+DPP+GDVEYL AFRT+V P+A EF PD+VLVSAG
Sbjct: 903 GSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAG 962
Query: 913 FDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNAL 972
FDA+EGH PLGGY VTA+CFGHLT+QLMTLA GRVVLALEGGHDLTAICDASEACV+AL
Sbjct: 963 FDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSAL 1022
Query: 973 LGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVPRGCALAGAQL--QEE 1030
L EL+PL E +L Q PN+NAV +L+K+IEIQSK+W V+ A G +L AQ EE
Sbjct: 1023 LSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEE 1082
Query: 1031 TETVSALASLTVDVEQPFA----QEDSRTAGEPMEEEPAL 1066
ETVSA+A L+V EQ A + R A EPME+EPAL
Sbjct: 1083 AETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL 1122
>gi|153085395 histone deacetylase 4 [Homo sapiens]
Length = 1084
Score = 1134 bits (2934), Expect = 0.0
Identities = 627/1093 (57%), Positives = 779/1093 (71%), Gaps = 60/1093 (5%)
Query: 1 MHSMISSVDVKSEVPVGLEPIS-PLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQI 59
++ M S+VDV + +P+ + P + P+DLR D + +PV +P +RE+QLQQELL ++Q+QQI
Sbjct: 25 VNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQI 84
Query: 60 QKQLLIAEFQKQHENLTRQHQAQLQEHIK---ELLAIKQQQELLEKEQKLEQQRQEQEVE 116
Q+Q+LIAEFQ+QHE L+RQH+AQL EHIK E+LA+K QQELLE ++KLE+ RQEQE+E
Sbjct: 85 QRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELE 144
Query: 117 RHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLW 176
+ REQ+L L+ K++G+E AVASTEVK KLQEF+L+K K NH +S P+ W
Sbjct: 145 KQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVLNKK--KALAHRNLNHCISSDPRYW 202
Query: 177 YTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAE 236
Y H+SLDQSSPP SG S SY + + G DAKDDFPLRKTASEPNLK+RSRLKQKVAE
Sbjct: 203 YGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAE 262
Query: 237 RRSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPP 296
RRSSPLLRRKDG VVT+ KKR +VT+S+ SS+ PGSGPSSPNN EN + P
Sbjct: 263 RRSSPLLRRKDGPVVTALKKRPLDVTDSACSSA-PGSGPSSPNNSSGSVSAENGIAPAVP 321
Query: 297 TPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQ 356
+ AE ++ R++ E S L LYTSPSLPNITLGLPA + ++ ++
Sbjct: 322 SIPAETSLAH-RLVAREGSAAPLPLYTSPSLPNITLGLPATGPSAGTAGQ-QDAERLTLP 379
Query: 357 TLRQGVPL-PGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAG- 414
L+Q + L PG + P S+ P LE + ++H LLQH++L EQ Q LV G
Sbjct: 380 ALQQRLSLFPGTH--LTPYLSTSP---LE-RDGGAAHSPLLQHMVLLEQPPAQAPLVTGL 433
Query: 415 -GVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQST--LAQLVIQQQHQQF 471
+PLH QS L +R+SP I HKL +HRPL RTQSAPLPQ+ L LVIQQQHQQF
Sbjct: 434 GALPLHAQS-LVGADRVSPSI---HKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQF 489
Query: 472 LEKQKQY--QQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQE----DRAPSSGN 525
LEK KQ QQQ+ MNK++ K E +QP SH EE EEEL+ QA+ + DR P
Sbjct: 490 LEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPYLDRLPGQ-- 547
Query: 526 STRSDSSACVDDTLGQVGAVKVKEEPVDSDEDAQI--------QEMESGEQAAFMQQPFL 577
+ Q G V+VK+EP++SDE+ Q S ++ F QQ L
Sbjct: 548 ----------KEAHAQAG-VQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALL 596
Query: 578 -EPTHTRALSVRQAPLAAVGMD-GLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGI 635
E L QA + A G+ HR +SR SSPA++ P + P +P TG+
Sbjct: 597 LEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGL 656
Query: 636 AYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHS 695
YD LMLKHQC CG+S++HPEHAGRIQSIWSRLQETGL KCE I+GRKA+LEE+Q VHS
Sbjct: 657 VYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHS 716
Query: 696 EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAV 755
E H+LLYGTNPL+ QKLD + LLG + F LPCGG+GVDSDTIWNE+HS+GAAR+AV
Sbjct: 717 EAHTLLYGTNPLNRQKLDSKKLLGSLASVFVR-LPCGGVGVDSDTIWNEVHSAGAARLAV 775
Query: 756 GCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKIL 815
GCV+EL KVA+GELKNGFAVVRPPGHHAEEST MGFC+FNSVA+ AK L+ +L++SKIL
Sbjct: 776 GCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKIL 835
Query: 816 IVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWT 875
IVD DVHHGNGTQQAFY+DPS+LY+SLHRYD+GNFFPGSGAP+EVGTG G G+N+N+A+T
Sbjct: 836 IVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFT 895
Query: 876 GGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGH 935
GGLDPPMGD EYL AFRT+V P+A EF PD+VLVS+GFDA+EGH PLGGY ++A+CFG+
Sbjct: 896 GGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGY 955
Query: 936 LTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVI 995
LTKQLM LA GR+VLALEGGHDLTAICDASEACV+ALLGNEL+PL E +L Q PN NAV
Sbjct: 956 LTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVR 1015
Query: 996 SLQKIIEIQSKYWKSVRMVAVPRGCALAGAQL--QEETETVSALASLTVDVEQPFAQEDS 1053
S++K++EI SKYW+ ++ G +L AQ EE ETV+A+ASL+V V+ +
Sbjct: 1016 SMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVK----PAEK 1071
Query: 1054 RTAGEPMEEEPAL 1066
R EPMEEEP L
Sbjct: 1072 RPDEEPMEEEPPL 1084
>gi|7662280 histone deacetylase 9 isoform 3 [Homo sapiens]
Length = 590
Score = 1126 bits (2913), Expect = 0.0
Identities = 574/574 (100%), Positives = 574/574 (100%)
Query: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60
MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ
Sbjct: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60
Query: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR 120
KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR
Sbjct: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR 120
Query: 121 EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA 180
EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA
Sbjct: 121 EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA 180
Query: 181 HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS 240
HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS
Sbjct: 181 HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS 240
Query: 241 PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA 300
PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA
Sbjct: 241 PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA 300
Query: 301 EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ 360
EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ
Sbjct: 301 EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ 360
Query: 361 GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP 420
GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP
Sbjct: 361 GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP 420
Query: 421 QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ 480
QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ
Sbjct: 421 QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ 480
Query: 481 QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG 540
QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG
Sbjct: 481 QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG 540
Query: 541 QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQ 574
QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQ
Sbjct: 541 QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQ 574
>gi|169234807 histone deacetylase 7 isoform a [Homo sapiens]
Length = 991
Score = 674 bits (1739), Expect = 0.0
Identities = 454/1023 (44%), Positives = 572/1023 (55%), Gaps = 126/1023 (12%)
Query: 75 LTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGR 134
L Q +L H+ LA QQQ +E +L E++ +EQ+L L KD+ +
Sbjct: 59 LALQRPQRLHHHL--FLAGLQQQRSVEP-MRLSMDTPMPELQVGPQEQELRQLLHKDKSK 115
Query: 135 ERAVASTEVKQKLQEFLLSKSAT---KDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPP 191
AVAS+ VKQKL E +L K + N L A + L PP
Sbjct: 116 RSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPP 175
Query: 192 LSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVV 251
+ +LP D + FPLRKT SEPNLK+R + K+ + ERR +PLLR++ +
Sbjct: 176 VP--------SLPS--DPPEHFPLRKTVSEPNLKLRYKPKKSL-ERRKNPLLRKE--SAP 222
Query: 252 TSFKKRMFEVT--ESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPH-AEQMVSQQR 308
S ++R E S SSS+P SG SSPN+ G P P + + QR
Sbjct: 223 PSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHG-----------PNPILGSEALLGQR 271
Query: 309 ILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVP----- 363
+ + E S+ +L T LP ITLGLPA P++ ++ L G P
Sbjct: 272 LRLQETSVAPFALPTVSLLPAITLGLPA-PARADSDRRTHPTLGPRGPIL--GSPHTPLF 328
Query: 364 ----LPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLH 419
L + GG++P S P + L+ P+ SH LL L G +P H
Sbjct: 329 LPHGLEPEAGGTLP-SRLQPILLLD---PSGSHAPLLTVPGL------------GPLPFH 372
Query: 420 PQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQ 479
L T ER+S H PL+RT+S PLP S A Q LE+ K +
Sbjct: 373 FAQSLMTTERLSGS-------GLHWPLSRTRSEPLPPSATAPPPPGPM-QPRLEQLKTHV 424
Query: 480 QQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTL 539
Q ++ +S + ++P + E+L+ D VDD L
Sbjct: 425 Q------VIKRSAKPSEKPRLRQIPSAEDLETDGG---------------GPGQVVDDGL 463
Query: 540 GQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDG 599
+E E ++ Q +Q L R S L + G
Sbjct: 464 EH------RELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRG-STGDTVLLPLAQGG 516
Query: 600 LEKHRLVSRTHSSPAASV---LPHPAMDRPLQPGS---------ATGIAYDPLMLKHQCV 647
HR +SR SSPAA P PA + S TG+ YD +MLKHQC
Sbjct: 517 ---HRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCS 573
Query: 648 CGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPL 707
CG+++ HPEHAGRIQSIWSRLQE GL ++CE ++GRKASLEE+Q VHSE H LLYGTNPL
Sbjct: 574 CGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPL 633
Query: 708 DGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVAS 767
KLD L G +Q+ F LPCGG+GVD+DTIWNELHSS AAR A G V +LA KVAS
Sbjct: 634 SRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVAS 693
Query: 768 GELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGT 827
ELKNGFAVVRPPGHHA+ STAMGFCFFNSVAI + L+ Q SKILIVD DVHHGNGT
Sbjct: 694 RELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGT 753
Query: 828 QQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEY 887
QQ FY DPS+LYISLHR+D+GNFFPGSGA +EVG G GEG+N+N+AW GGLDPPMGD EY
Sbjct: 754 QQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEY 813
Query: 888 LEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGR 947
L AFR +V P+A+EF PD+VLVSAGFDA EGH PLGGY V+AKCFG++T+QLM LA G
Sbjct: 814 LAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGA 873
Query: 948 VVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKY 1007
VVLALEGGHDLTAICDASEACV ALLGN ++PL+E+ Q PN+NA+ SL+ +I + SKY
Sbjct: 874 VVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKY 933
Query: 1008 WKSVRMVA------VPRGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPME 1061
W ++ +A VPR + GA +EE E V+ALASL+V + ED + E
Sbjct: 934 WGCMQRLASCPDSWVPR---VPGAD-KEEVEAVTALASLSVGI----LAEDRPSEQLVEE 985
Query: 1062 EEP 1064
EEP
Sbjct: 986 EEP 988
>gi|148539870 histone deacetylase 7 isoform d [Homo sapiens]
Length = 954
Score = 653 bits (1684), Expect = 0.0
Identities = 444/1015 (43%), Positives = 553/1015 (54%), Gaps = 147/1015 (14%)
Query: 75 LTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGR 134
L Q +L H+ LA QQQ +E +L E++ +EQ+L L KD+ +
Sbjct: 59 LALQRPQRLHHHL--FLAGLQQQRSVEP-MRLSMDTPMPELQVGPQEQELRQLLHKDKSK 115
Query: 135 ERAVASTEVKQKLQEFLLSKSAT---KDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPP 191
AVAS+ VKQKL E +L K + N L A + L PP
Sbjct: 116 RSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPP 175
Query: 192 LSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVV 251
+ +LP D + FPLRKT SEPNLK+R + K+ + ERR +PLLR++ +
Sbjct: 176 VP--------SLPS--DPPEHFPLRKTVSEPNLKLRYKPKKSL-ERRKNPLLRKE--SAP 222
Query: 252 TSFKKRMFEVT--ESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRI 309
S ++R E S SSS+P SG SSPN+ G P P R
Sbjct: 223 PSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHG-----------PNPILGSEADSDR- 270
Query: 310 LIHEDSMNLLSLYTSPSLP--NITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQ 367
T P+L LG P P L L +
Sbjct: 271 ------------RTHPTLGPRGPILGSPHTPLFLPHG-------------------LEPE 299
Query: 368 YGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATK 427
GG++P S P + L+ P+ SH LL L G +P H L T
Sbjct: 300 AGGTLP-SRLQPILLLD---PSGSHAPLLTVPGL------------GPLPFHFAQSLMTT 343
Query: 428 ERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKL 487
ER+S H PL+RT+S PLP S A Q LE+ K + Q +
Sbjct: 344 ERLSGS-------GLHWPLSRTRSEPLPPSATAPPPPGPM-QPRLEQLKTHVQ------V 389
Query: 488 LSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKV 547
+ +S + ++P + E+L+ D VDD L
Sbjct: 390 IKRSAKPSEKPRLRQIPSAEDLETDGG---------------GPGQVVDDGLEH------ 428
Query: 548 KEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVS 607
+E E ++ Q +Q L R S L + G HR +S
Sbjct: 429 RELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRG-STGDTVLLPLAQGG---HRPLS 484
Query: 608 RTHSSPAASV---LPHPAMDRPLQPGS---------ATGIAYDPLMLKHQCVCGNSTTHP 655
R SSPAA P PA + S TG+ YD +MLKHQC CG+++ HP
Sbjct: 485 RAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHP 544
Query: 656 EHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPR 715
EHAGRIQSIWSRLQE GL ++CE ++GRKASLEE+Q VHSE H LLYGTNPL KLD
Sbjct: 545 EHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNG 604
Query: 716 ILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFA 775
L G +Q+ F LPCGG+GVD+DTIWNELHSS AAR A G V +LA KVAS ELKNGFA
Sbjct: 605 KLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFA 664
Query: 776 VVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADP 835
VVRPPGHHA+ STAMGFCFFNSVAI + L+ Q SKILIVD DVHHGNGTQQ FY DP
Sbjct: 665 VVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDP 724
Query: 836 SILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIV 895
S+LYISLHR+D+GNFFPGSGA +EVG G GEG+N+N+AW GGLDPPMGD EYL AFR +V
Sbjct: 725 SVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVV 784
Query: 896 KPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGG 955
P+A+EF PD+VLVSAGFDA EGH PLGGY V+AKCFG++T+QLM LA G VVLALEGG
Sbjct: 785 MPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGG 844
Query: 956 HDLTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVA 1015
HDLTAICDASEACV ALLGN ++PL+E+ Q PN+NA+ SL+ +I + SKYW ++ +A
Sbjct: 845 HDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLA 904
Query: 1016 ------VPRGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEP 1064
VPR + GA +EE E V+ALASL+V + ED + EEEP
Sbjct: 905 SCPDSWVPR---VPGAD-KEEVEAVTALASLSVGI----LAEDRPSEQLVEEEEP 951
>gi|13128864 histone deacetylase 6 [Homo sapiens]
Length = 1215
Score = 282 bits (722), Expect = 1e-75
Identities = 169/408 (41%), Positives = 234/408 (57%), Gaps = 39/408 (9%)
Query: 613 PAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETG 672
P +L P + S TG+ YD M+ H C +S HPE RI I RL+E G
Sbjct: 467 PVLPILTWPVLQ------SRTGLVYDQNMMNH-CNLWDSH-HPEVPQRILRIMCRLEELG 518
Query: 673 LLNKCERIQGRKASLEEIQLVHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPC 731
L +C + R A+ E+ HS E+ L T + ++L +S F S C
Sbjct: 519 LAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHR------ESSNFDSIYIC 572
Query: 732 GGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMG 791
+ A++A G L V SGE+ NG AVVRPPGHHAE+ A G
Sbjct: 573 PS-------------TFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACG 619
Query: 792 FCFFNSVAITAKYLRD-QLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNF 850
FCFFNSVA+ A++ + + +ILIVD DVHHGNGTQ F DPS+LY+SLHRYD G F
Sbjct: 620 FCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTF 679
Query: 851 FP--GSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVL 908
FP GA +++G G G+ +N+AW G P MGD +YL A+ +V P+A EF+P++VL
Sbjct: 680 FPMGDEGASSQIGRAAGTGFTVNVAWNG---PRMGDADYLAAWHRLVLPIAYEFNPELVL 736
Query: 909 VSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEAC 968
VSAGFDA G PLGG +V+ + + HLT LM LA GR++L LEGG++LT+I ++ AC
Sbjct: 737 VSAGFDAARG--DPLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAAC 794
Query: 969 VNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAV 1016
+LLG +P L + P A+ S+ + I++ +YW+S+R++ V
Sbjct: 795 TRSLLG---DPPPLLTLPRPPLSGALASITETIQVHRRYWRSLRVMKV 839
Score = 236 bits (603), Expect = 7e-62
Identities = 143/382 (37%), Positives = 212/382 (55%), Gaps = 32/382 (8%)
Query: 631 SATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEI 690
+ TG+ D + + C+ +S PE R+ +I +L + GLL++C Q R A EE+
Sbjct: 84 AGTGLVLDEQLNEFHCLWDDS--FPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEEL 141
Query: 691 QLVHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSG 749
LVHS E+ L+ T ++ +L R+L D+++ +S
Sbjct: 142 MLVHSLEYIDLMETTQYMNEGEL--RVLADT-----------------YDSVYLHPNSYS 182
Query: 750 AARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQL 809
A +A G V+ L V E++NG A++RPPGHHA+ S G+C FN VA+ A+Y + +
Sbjct: 183 CACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKH 242
Query: 810 NISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPN--EVGTGLGEG 867
I ++LIVD DVHHG GTQ F DPS+LY S+HRY++G F+P A N G G G+G
Sbjct: 243 RIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQG 302
Query: 868 YNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYK 927
Y IN+ W M D +Y+ AF ++ PVA EF P +VLV+AGFDAL+G P G
Sbjct: 303 YTINVPWN---QVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQG--DPKGEMA 357
Query: 928 VTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQ 987
T F LT LM LA G+++L+LEGG++L A+ + A ++ LLG+ P+ E
Sbjct: 358 ATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPC-PMLES--PG 414
Query: 988 SPNMNAVISLQKIIEIQSKYWK 1009
+P +A S+ +E +W+
Sbjct: 415 APCRSAQASVSCALEALEPFWE 436
>gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens]
Length = 669
Score = 236 bits (601), Expect = 1e-61
Identities = 143/391 (36%), Positives = 213/391 (54%), Gaps = 33/391 (8%)
Query: 633 TGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQL 692
T + Y M + + + E R+ + RL++ GL +C R+ R+AS EE+ L
Sbjct: 3 TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62
Query: 693 VHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAA 751
VHS E+ SL+ T L ++L L D I+ + A
Sbjct: 63 VHSPEYVSLVRETQVLGKEELQ-------------------ALSGQFDAIYFHPSTFHCA 103
Query: 752 RMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNI 811
R+A G ++L V +G ++NG A+VRPPGHH + + A GFC FN+VAI A + + + +
Sbjct: 104 RLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGL 163
Query: 812 SKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP--GSGAPNEVGTGLGEGYN 869
+IL+VD DVHHG G Q F DPS+LY S HRY+ G F+P + VG G G G+
Sbjct: 164 HRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFT 223
Query: 870 INIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVT 929
+N+ W MG+ +Y+ AF ++ P+A EFDP++VLVSAGFD+ G P G + T
Sbjct: 224 VNLPWN---QVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIG--DPEGQMQAT 278
Query: 930 AKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSP 989
+CF HLT+ L LA GRV LEGG+ L ++ ++ V LLG+ PL+ + +P
Sbjct: 279 PECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPM---AP 335
Query: 990 NMNAVISLQKIIEIQSKYWKSVR---MVAVP 1017
+A+ S+Q Q+ +WKS++ + AVP
Sbjct: 336 CQSALESIQSARAAQAPHWKSLQQQDVTAVP 366
>gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens]
Length = 649
Score = 202 bits (514), Expect = 1e-51
Identities = 130/391 (33%), Positives = 197/391 (50%), Gaps = 53/391 (13%)
Query: 633 TGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQL 692
T + Y M + + + E R+ + RL++ GL +C R+ R+AS EE+ L
Sbjct: 3 TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62
Query: 693 VHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAA 751
VHS E+ SL+ T L ++L L D I+ + A
Sbjct: 63 VHSPEYVSLVRETQVLGKEELQ-------------------ALSGQFDAIYFHPSTFHCA 103
Query: 752 RMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNI 811
R+A G ++L V +G ++NG A+VRPPGHH + + A GFC FN+VAI A + + + +
Sbjct: 104 RLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGL 163
Query: 812 SKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP--GSGAPNEVGTGLGEGYN 869
+IL+VD DVHHG G Q F DPS+LY S HRY+ G F+P + VG G G G+
Sbjct: 164 HRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFT 223
Query: 870 INIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVT 929
+N+ W MG+ +Y+ AF ++ P+A E G + T
Sbjct: 224 VNLPWN---QVGMGNADYVAAFLHLLLPLAFE----------------------GQMQAT 258
Query: 930 AKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSP 989
+CF HLT+ L LA GRV LEGG+ L ++ ++ V LLG+ PL+ + +P
Sbjct: 259 PECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPM---AP 315
Query: 990 NMNAVISLQKIIEIQSKYWKSVR---MVAVP 1017
+A+ S+Q Q+ +WKS++ + AVP
Sbjct: 316 CQSALESIQSARAAQAPHWKSLQQQDVTAVP 346
>gi|116284376 histone deacetylase 2 [Homo sapiens]
Length = 582
Score = 111 bits (278), Expect = 3e-24
Identities = 105/384 (27%), Positives = 168/384 (43%), Gaps = 61/384 (15%)
Query: 654 HPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHH----SLLYGTNPLDG 709
HP RI+ + L GL K E + KA+ EE+ HS+ + + N +
Sbjct: 123 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEY 182
Query: 710 QKLDPRILLGDDSQKF-----FSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASK 764
K R +G+D F F L GG V N + A A G
Sbjct: 183 SKQMQRFNVGEDCPVFDGLFEFCQLSTGG-SVAGAVKLNRQQTDMAVNWAGGL------- 234
Query: 765 VASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHG 824
HHA++S A GFC+ N + + L ++L +D+D+HHG
Sbjct: 235 -----------------HHAKKSEASGFCYVNDIVLAILELLKY--HQRVLYIDIDIHHG 275
Query: 825 NGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGD 884
+G ++AFY ++ +S H+Y G +FPG+G ++G G G+ Y +N G+D D
Sbjct: 276 DGVEEAFYTTDRVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNFPMRDGID----D 329
Query: 885 VEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLA 944
Y + F+ I+ V + + P V++ G D+L G LG + +T K GH K + +
Sbjct: 330 ESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDR--LGCFNLTVK--GH-AKCVEVVK 384
Query: 945 DGRVVLALEGGHDLT----AICDASEACV--NALLGNEL------EPLAEDI-LHQSP-N 990
+ L + GG T A C E V + + NEL E D LH SP N
Sbjct: 385 TFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSN 444
Query: 991 MNAVISLQKIIEIQSKYWKSVRMV 1014
M + + + +I+ + ++++RM+
Sbjct: 445 MTNQNTPEYMEKIKQRLFENLRML 468
>gi|13128860 histone deacetylase 1 [Homo sapiens]
Length = 482
Score = 110 bits (275), Expect = 7e-24
Identities = 105/385 (27%), Positives = 170/385 (44%), Gaps = 63/385 (16%)
Query: 654 HPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGT----NPLDG 709
HP RI+ + L GL K E + KA+ EE+ HS+ + + N +
Sbjct: 28 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEY 87
Query: 710 QKLDPRILLGDDSQKF-----FSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASK 764
K R +G+D F F L GG +AS
Sbjct: 88 SKQMQRFNVGEDCPVFDGLFEFCQLSTGG--------------------------SVASA 121
Query: 765 VASGELKNGFAVVRPPG-HHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHH 823
V + + AV G HHA++S A GFC+ N + + L ++L +D+D+HH
Sbjct: 122 VKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQ--RVLYIDIDIHH 179
Query: 824 GNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMG 883
G+G ++AFY ++ +S H+Y G +FPG+G ++G G G+ Y +N G+D
Sbjct: 180 GDGVEEAFYTTDRVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNYPLRDGID---- 233
Query: 884 DVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTL 943
D Y F+ ++ V + F P V++ G D+L G LG + +T K GH K + +
Sbjct: 234 DESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDR--LGCFNLTIK--GH-AKCVEFV 288
Query: 944 ADGRVVLALEGGHDLT----AICDASEACV--NALLGNEL------EPLAEDI-LHQSP- 989
+ + + GG T A C E V + + NEL E D LH SP
Sbjct: 289 KSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPS 348
Query: 990 NMNAVISLQKIIEIQSKYWKSVRMV 1014
NM + + + +I+ + ++++RM+
Sbjct: 349 NMTNQNTNEYLEKIKQRLFENLRML 373
>gi|8923769 histone deacetylase 8 [Homo sapiens]
Length = 377
Score = 107 bits (268), Expect = 5e-23
Identities = 93/362 (25%), Positives = 167/362 (46%), Gaps = 42/362 (11%)
Query: 623 MDRPLQPGSATGIAYDPLML---KHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCER 679
M+ P +P + G + P+ + ++ +C + P+ A + S+ ++ L +
Sbjct: 1 MEEPEEPADS-GQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSL---IEAYALHKQMRI 56
Query: 680 IQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVD-- 737
++ + AS+EE+ H++ + Q L GDD GLG D
Sbjct: 57 VKPKVASMEEMATFHTDAYL----------QHLQKVSQEGDDDHPDSIEY---GLGYDCP 103
Query: 738 -SDTIWNELHSSGAARM-AVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFF 795
++ I++ + G A + A C+I+ KVA G+ HHA++ A GFC+
Sbjct: 104 ATEGIFDYAAAIGGATITAAQCLIDGMCKVAIN-WSGGW-------HHAKKDEASGFCYL 155
Query: 796 NSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSG 855
N + LR + +IL VDLD+HHG+G + AF ++ +SLH++ G FFPG+G
Sbjct: 156 NDAVLGILRLRRKFE--RILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPG-FFPGTG 212
Query: 856 APNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDA 915
++VG G G Y++N+ G+ D +Y + +++K V + F+P V++ G D
Sbjct: 213 DVSDVGLGKGRYYSVNVPIQDGIQ----DEKYYQICESVLKEVYQAFNPKAVVLQLGADT 268
Query: 916 LEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGN 975
+ G P+ + +T G K ++ ++L GG++L +LG
Sbjct: 269 IAG--DPMCSFNMTPVGIGKCLKYILQWQLATLILG-GGGYNLANTARCWTYLTGVILGK 325
Query: 976 EL 977
L
Sbjct: 326 TL 327
>gi|13128862 histone deacetylase 3 [Homo sapiens]
Length = 428
Score = 89.7 bits (221), Expect = 1e-17
Identities = 47/136 (34%), Positives = 74/136 (54%), Gaps = 9/136 (6%)
Query: 782 HHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYIS 841
HHA++ A GFC+ N + I L ++L +D+D+HHG+G Q+AFY ++ +S
Sbjct: 134 HHAKKFEASGFCYVNDIVIGILELLKYH--PRVLYIDIDIHHGDGVQEAFYLTDRVMTVS 191
Query: 842 LHRYDEGN-FFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAK 900
H+Y GN FFPG+G EVG G Y +N+ G+D D Y F+ ++ V
Sbjct: 192 FHKY--GNYFFPGTGDMYEVGAESGRYYCLNVPLRDGID----DQSYKHLFQPVINQVVD 245
Query: 901 EFDPDMVLVSAGFDAL 916
+ P +++ G D+L
Sbjct: 246 FYQPTCIVLQCGADSL 261
>gi|217272877 histone deacetylase 11 isoform 1 [Homo sapiens]
Length = 347
Score = 67.4 bits (163), Expect = 7e-11
Identities = 75/317 (23%), Positives = 135/317 (42%), Gaps = 51/317 (16%)
Query: 649 GNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHH--SLLYGTNP 706
G HP AG+ + + L+E LL+ ++ R+AS E++ +VH+ + L +
Sbjct: 30 GLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAV 89
Query: 707 LDGQKLDPRILLGDD--SQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASK 764
++ P I L + +K L R G I +A K
Sbjct: 90 ATITEIPPVIFLPNFLVQRKVLRPL----------------------RTQTGGTI-MAGK 126
Query: 765 VASGELKNGFAVVRPPG-HHAEESTAMGFCFFNSVAITAKYLRDQLN-ISKILIVDLDVH 822
+A ++ G+A+ G HH GFC + + + K+L +++ IS+ I+DLD H
Sbjct: 127 LA---VERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAH 183
Query: 823 HGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPM 882
GNG ++ F D + + ++ + +PG + + + W G +
Sbjct: 184 QGNGHERDFMDDKRVYIMDVY---NRHIYPGDRFAKQ-----AIRRKVELEW--GTE--- 230
Query: 883 GDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMT 942
D EYL+ +K +E PD+V+ +AG D LEG LGG ++ + +
Sbjct: 231 -DDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDR--LGGLSISPAGIVKRDELVFR 287
Query: 943 LADGR---VVLALEGGH 956
+ GR +++ GG+
Sbjct: 288 MVRGRRVPILMVTSGGY 304
>gi|209862883 histone deacetylase 11 isoform 2 [Homo sapiens]
Length = 296
Score = 67.4 bits (163), Expect = 7e-11
Identities = 73/313 (23%), Positives = 129/313 (41%), Gaps = 66/313 (21%)
Query: 649 GNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLD 708
G HP AG+ + + L+E LL+ ++ R+AS E++ +VH+ + N L
Sbjct: 2 GLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRY-----LNELK 56
Query: 709 GQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASG 768
+ L P R G I +A K+A
Sbjct: 57 RKVLRP------------------------------------LRTQTGGTI-MAGKLA-- 77
Query: 769 ELKNGFAVVRPPG-HHAEESTAMGFCFFNSVAITAKYLRDQLN-ISKILIVDLDVHHGNG 826
++ G+A+ G HH GFC + + + K+L +++ IS+ I+DLD H GNG
Sbjct: 78 -VERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNG 136
Query: 827 TQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVE 886
++ F D + + ++ + +PG + + + W G + D E
Sbjct: 137 HERDFMDDKRVYIMDVY---NRHIYPGDRFAKQ-----AIRRKVELEW--GTE----DDE 182
Query: 887 YLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADG 946
YL+ +K +E PD+V+ +AG D LEG LGG ++ + + + G
Sbjct: 183 YLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDR--LGGLSISPAGIVKRDELVFRMVRG 240
Query: 947 R---VVLALEGGH 956
R +++ GG+
Sbjct: 241 RRVPILMVTSGGY 253
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 59.3 bits (142), Expect = 2e-08
Identities = 42/111 (37%), Positives = 65/111 (58%), Gaps = 11/111 (9%)
Query: 45 QLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHI----KELLAIKQQQELL 100
Q QQ+LLL+QQQ Q+Q+QLL + + + L Q QAQLQ+ + +E L +QQQ+LL
Sbjct: 236 QQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLL 295
Query: 101 EKEQKL--EQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149
+++Q+ +QQ Q +E E+ L D G E+ E++Q+ QE
Sbjct: 296 QQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQ-----ELEQQRQE 341
Score = 57.0 bits (136), Expect = 9e-08
Identities = 30/92 (32%), Positives = 59/92 (64%), Gaps = 2/92 (2%)
Query: 33 MMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLA 92
+ P + + +++QLQ + +Q+QQ++Q+Q + Q+ E Q Q QLQ+ ++E
Sbjct: 146 LKPELQLMHQQQQLQPQQ--VQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQL 203
Query: 93 IKQQQELLEKEQKLEQQRQEQEVERHRREQQL 124
++QQQE L+++Q L+QQ Q Q+ + ++++QL
Sbjct: 204 LQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQL 235
Score = 55.8 bits (133), Expect = 2e-07
Identities = 64/275 (23%), Positives = 113/275 (41%), Gaps = 38/275 (13%)
Query: 335 PAVPSQLNASNSLKE----KQKCETQTLRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNS 390
PAV + + AS +E +++ + Q L Q P P Q PH+ L+ +P
Sbjct: 67 PAVSAPVGASEIAEETRPGQRELQLQQLEQQ-PEPQQQPQHEQLQQPQPHLELQQQPQQD 125
Query: 391 SHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQ 450
Q L Q L+++ Q +H Q + P ++ H+ + +P +
Sbjct: 126 GQQQLSQ---LQQEKHQS---------VHHQE-------LKPELQLMHQQQQLQPQQVQE 166
Query: 451 SAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQ 510
L Q Q Q QQ L++Q+Q QQQ+ +LL + EQL+Q L + +E+LQ
Sbjct: 167 QQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQ--QQLLQQQEQLQ 224
Query: 511 GDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAA 570
Q Q+ + + GQ+ ++ + + AQ+Q+ +Q A
Sbjct: 225 QQQFQQQQ------EQLQQQQQLLLLQQQGQL------QQQLLQQQQAQLQQQLLEQQQA 272
Query: 571 FMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRL 605
+QQ L + +Q L + L++ +L
Sbjct: 273 QLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQL 307
Score = 54.7 bits (130), Expect = 5e-07
Identities = 35/99 (35%), Positives = 63/99 (63%), Gaps = 10/99 (10%)
Query: 42 REKQLQQELLLIQQQQQIQKQ---LLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQE 98
+++QLQQ+ QQQ+Q+Q+Q LL+ + + + L +Q QAQLQ+ + E + QQ+
Sbjct: 219 QQEQLQQQQFQ-QQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQ 277
Query: 99 LLEKEQKLEQQRQEQEVERHRREQ------QLPPLRGKD 131
LL ++Q+ QQ+Q+Q++ + ++EQ Q PPL ++
Sbjct: 278 LLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEE 316
Score = 53.1 bits (126), Expect = 1e-06
Identities = 39/101 (38%), Positives = 60/101 (59%), Gaps = 19/101 (18%)
Query: 42 REKQLQQELLLIQQQQQIQKQLLIAE----FQKQHENLTRQHQAQLQEHIKELLAIKQQQ 97
++ QLQQ+L L QQQ Q+Q+QLL+ + Q+Q + L +Q Q QLQ+ + ++ ++
Sbjct: 258 QQAQLQQQL-LEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEE 316
Query: 98 EL----------LEKEQKLEQQRQE----QEVERHRREQQL 124
E L EQ+LEQQRQE QE+ER + ++QL
Sbjct: 317 EEEVELELMPVDLGSEQELEQQRQELERQQELERQQEQRQL 357
Score = 48.9 bits (115), Expect = 3e-05
Identities = 34/112 (30%), Positives = 66/112 (58%), Gaps = 20/112 (17%)
Query: 43 EKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEK 102
+ Q QE ++QQQ+Q+Q+Q+ Q + L +Q Q QL QQQ+LL++
Sbjct: 178 QTQQAQEQQVLQQQEQLQQQV-------QEQQLLQQQQEQL-----------QQQQLLQQ 219
Query: 103 EQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSK 154
+++L+QQ+ +Q+ E+ +++QQL L + +G+ + + + +LQ+ LL +
Sbjct: 220 QEQLQQQQFQQQQEQLQQQQQL--LLLQQQGQLQQQLLQQQQAQLQQQLLEQ 269
Score = 46.6 bits (109), Expect = 1e-04
Identities = 38/130 (29%), Positives = 68/130 (52%), Gaps = 28/130 (21%)
Query: 43 EKQLQQELLLIQQQQQIQKQLL------------------------IAEFQKQHENLTRQ 78
++Q QQ+LL QQQ+Q+Q+Q L E ++Q + L RQ
Sbjct: 287 QQQQQQQLLQ-QQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQ 345
Query: 79 HQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAV 138
+ + Q+ ++ L +K Q+EL + EQ+LEQ Q+Q++E+ + +L P+ + +E +
Sbjct: 346 QELERQQEQRQ-LQLKLQEELQQLEQQLEQ--QQQQLEQQEVQLELTPVELGAQQQEVQL 402
Query: 139 ASTEVKQKLQ 148
T V+ +LQ
Sbjct: 403 ELTPVQPELQ 412
Score = 43.9 bits (102), Expect = 8e-04
Identities = 33/106 (31%), Positives = 60/106 (56%), Gaps = 9/106 (8%)
Query: 47 QQELLLIQQQ--QQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQ 104
QQ+L +QQ+ Q + Q L E Q H+ Q Q Q Q+ ++E ++QQQE L+ +Q
Sbjct: 127 QQQLSQLQQEKHQSVHHQELKPELQLMHQ----QQQLQPQQ-VQEQQRLQQQQEQLQTQQ 181
Query: 105 KLEQQ--RQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQ 148
EQQ +Q++++++ +EQQL + + +++ + E Q+ Q
Sbjct: 182 AQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQ 227
Score = 39.3 bits (90), Expect = 0.020
Identities = 37/121 (30%), Positives = 62/121 (51%), Gaps = 14/121 (11%)
Query: 39 PVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQL--QEHIKELLAIKQQ 96
P RE QLQQ ++QQ + Q+Q + Q+ +L Q Q Q Q+ + +L K Q
Sbjct: 84 PGQRELQLQQ----LEQQPEPQQQPQHEQLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQ 139
Query: 97 ----QELLEKEQKLEQQRQ---EQEVERHRREQQLPPLRGKDRGRERAVASTE-VKQKLQ 148
QEL + Q + QQ+Q +Q E+ R +QQ L+ + ++ + E ++Q++Q
Sbjct: 140 SVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQ 199
Query: 149 E 149
E
Sbjct: 200 E 200
Score = 35.0 bits (79), Expect = 0.38
Identities = 33/141 (23%), Positives = 61/141 (43%), Gaps = 16/141 (11%)
Query: 393 QALLQHLLLKEQMRQ--QKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQ 450
Q LQ LL++Q Q Q+LL L Q L +E++ + + L + Q
Sbjct: 247 QGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQ 306
Query: 451 SAPLPQSTLAQLVIQ--------------QQHQQFLEKQKQYQQQIHMNKLLSKSIEQLK 496
P P + ++ +Q +Q LE+Q++ ++Q +L K E+L+
Sbjct: 307 LQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQELERQQEQRQLQLKLQEELQ 366
Query: 497 QPGSHLEEAEEELQGDQAMQE 517
Q LE+ +++L+ + E
Sbjct: 367 QLEQQLEQQQQQLEQQEVQLE 387
Score = 32.0 bits (71), Expect = 3.2
Identities = 43/167 (25%), Positives = 75/167 (44%), Gaps = 23/167 (13%)
Query: 393 QALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHK--------LPRHR 444
Q LLQ +EQ++QQ+L PL P+ + + P G+ + L R +
Sbjct: 292 QQLLQQQ--QEQLQQQQLQPP---PLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQ 346
Query: 445 PLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKL-LSKSIEQLKQPGSHLE 503
L R Q + QL +Q++ QQ ++ +Q QQQ+ ++ L + +L G+ +
Sbjct: 347 ELERQQ-----EQRQLQLKLQEELQQLEQQLEQQQQQLEQQEVQLELTPVEL---GAQQQ 398
Query: 504 EAEEELQGDQ-AMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKE 549
E + EL Q +Q + P++G + A + G V V+E
Sbjct: 399 EVQLELTPVQPELQLELVPAAGGGGAAVPGAPAAVVVAPPGYVVVQE 445
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 55.8 bits (133), Expect = 2e-07
Identities = 69/284 (24%), Positives = 120/284 (42%), Gaps = 46/284 (16%)
Query: 43 EKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEK 102
E L++E L +QQ+ + + L KQ + L +Q Q + HIK LL +Q++ +K
Sbjct: 348 ESTLRREFLRLQQENKSNSEAL-----KQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQK 402
Query: 103 EQKL---EQQRQE------QEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLS 153
E++ EQQR+E QE E+ RR + + LR ++ R +A E K+K E
Sbjct: 403 EERRRVEEQQRREREQRKLQEKEQQRRLEDMQALR-REEERRQAEREQEYKRKQLE---- 457
Query: 154 KSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDF 213
+ S +L A+ SL Q + LPG + +
Sbjct: 458 ----------EQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHY 507
Query: 214 -----PLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVT---ESS 265
P K A ++ R+R+ ++++SPL + K G+ T + + + +
Sbjct: 508 GRGMNPADKPAWAREVEERTRMN----KQQNSPLAKSKPGS--TGPEPPIPQASPGPPGP 561
Query: 266 VSSSSPGSGPSSPNNGPTGSVTENETSVLP---PTPHAEQMVSQ 306
+S + P P P GP S+ + + P P P ++ + Q
Sbjct: 562 LSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQ 605
Score = 34.3 bits (77), Expect = 0.64
Identities = 19/92 (20%), Positives = 52/92 (56%), Gaps = 11/92 (11%)
Query: 42 REKQLQQELLLIQQQQQIQKQL----LIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQ 97
R+ + + LL Q+Q++I++Q + E Q++ + + + Q ++++ A+++++
Sbjct: 381 RDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREE 440
Query: 98 ELLE-------KEQKLEQQRQEQEVERHRREQ 122
E + K ++LE+QRQ + ++R +++
Sbjct: 441 ERRQAEREQEYKRKQLEEQRQSERLQRQLQQE 472
Score = 31.2 bits (69), Expect = 5.4
Identities = 22/94 (23%), Positives = 51/94 (54%), Gaps = 10/94 (10%)
Query: 40 VVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQEL 99
V +++ ++E +Q+++Q Q + + Q R+ + QE+ ++ L ++Q E
Sbjct: 408 VEEQQRREREQRKLQEKEQ---QRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSER 464
Query: 100 LEKEQKLE-------QQRQEQEVERHRREQQLPP 126
L+++ + E QQ+Q+Q+ + +++QQL P
Sbjct: 465 LQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLP 498
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 55.8 bits (133), Expect = 2e-07
Identities = 69/284 (24%), Positives = 120/284 (42%), Gaps = 46/284 (16%)
Query: 43 EKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEK 102
E L++E L +QQ+ + + L KQ + L +Q Q + HIK LL +Q++ +K
Sbjct: 348 ESTLRREFLRLQQENKSNSEAL-----KQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQK 402
Query: 103 EQKL---EQQRQE------QEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLS 153
E++ EQQR+E QE E+ RR + + LR ++ R +A E K+K E
Sbjct: 403 EERRRVEEQQRREREQRKLQEKEQQRRLEDMQALR-REEERRQAEREQEYKRKQLE---- 457
Query: 154 KSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDF 213
+ S +L A+ SL Q + LPG + +
Sbjct: 458 ----------EQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHY 507
Query: 214 -----PLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVT---ESS 265
P K A ++ R+R+ ++++SPL + K G+ T + + + +
Sbjct: 508 GRGMNPADKPAWAREVEERTRMN----KQQNSPLAKSKPGS--TGPEPPIPQASPGPPGP 561
Query: 266 VSSSSPGSGPSSPNNGPTGSVTENETSVLP---PTPHAEQMVSQ 306
+S + P P P GP S+ + + P P P ++ + Q
Sbjct: 562 LSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQ 605
Score = 34.3 bits (77), Expect = 0.64
Identities = 19/92 (20%), Positives = 52/92 (56%), Gaps = 11/92 (11%)
Query: 42 REKQLQQELLLIQQQQQIQKQL----LIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQ 97
R+ + + LL Q+Q++I++Q + E Q++ + + + Q ++++ A+++++
Sbjct: 381 RDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREE 440
Query: 98 ELLE-------KEQKLEQQRQEQEVERHRREQ 122
E + K ++LE+QRQ + ++R +++
Sbjct: 441 ERRQAEREQEYKRKQLEEQRQSERLQRQLQQE 472
Score = 31.2 bits (69), Expect = 5.4
Identities = 22/94 (23%), Positives = 51/94 (54%), Gaps = 10/94 (10%)
Query: 40 VVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQEL 99
V +++ ++E +Q+++Q Q + + Q R+ + QE+ ++ L ++Q E
Sbjct: 408 VEEQQRREREQRKLQEKEQ---QRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSER 464
Query: 100 LEKEQKLE-------QQRQEQEVERHRREQQLPP 126
L+++ + E QQ+Q+Q+ + +++QQL P
Sbjct: 465 LQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLP 498
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 55.8 bits (133), Expect = 2e-07
Identities = 69/284 (24%), Positives = 120/284 (42%), Gaps = 46/284 (16%)
Query: 43 EKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEK 102
E L++E L +QQ+ + + L KQ + L +Q Q + HIK LL +Q++ +K
Sbjct: 348 ESTLRREFLRLQQENKSNSEAL-----KQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQK 402
Query: 103 EQKL---EQQRQE------QEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLS 153
E++ EQQR+E QE E+ RR + + LR ++ R +A E K+K E
Sbjct: 403 EERRRVEEQQRREREQRKLQEKEQQRRLEDMQALR-REEERRQAEREQEYKRKQLE---- 457
Query: 154 KSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDF 213
+ S +L A+ SL Q + LPG + +
Sbjct: 458 ----------EQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHY 507
Query: 214 -----PLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVT---ESS 265
P K A ++ R+R+ ++++SPL + K G+ T + + + +
Sbjct: 508 GRGMNPADKPAWAREVEERTRMN----KQQNSPLAKSKPGS--TGPEPPIPQASPGPPGP 561
Query: 266 VSSSSPGSGPSSPNNGPTGSVTENETSVLP---PTPHAEQMVSQ 306
+S + P P P GP S+ + + P P P ++ + Q
Sbjct: 562 LSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQ 605
Score = 34.3 bits (77), Expect = 0.64
Identities = 19/92 (20%), Positives = 52/92 (56%), Gaps = 11/92 (11%)
Query: 42 REKQLQQELLLIQQQQQIQKQL----LIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQ 97
R+ + + LL Q+Q++I++Q + E Q++ + + + Q ++++ A+++++
Sbjct: 381 RDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREE 440
Query: 98 ELLE-------KEQKLEQQRQEQEVERHRREQ 122
E + K ++LE+QRQ + ++R +++
Sbjct: 441 ERRQAEREQEYKRKQLEEQRQSERLQRQLQQE 472
Score = 31.2 bits (69), Expect = 5.4
Identities = 22/94 (23%), Positives = 51/94 (54%), Gaps = 10/94 (10%)
Query: 40 VVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQEL 99
V +++ ++E +Q+++Q Q + + Q R+ + QE+ ++ L ++Q E
Sbjct: 408 VEEQQRREREQRKLQEKEQ---QRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSER 464
Query: 100 LEKEQKLE-------QQRQEQEVERHRREQQLPP 126
L+++ + E QQ+Q+Q+ + +++QQL P
Sbjct: 465 LQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLP 498
>gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens]
Length = 748
Score = 55.8 bits (133), Expect = 2e-07
Identities = 91/395 (23%), Positives = 156/395 (39%), Gaps = 88/395 (22%)
Query: 15 PVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHEN 74
P + +S +T L++ + +++Q QQ+ QQQQ Q+Q +FQ Q
Sbjct: 138 PHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQ--QQFQAQQSA 195
Query: 75 LTRQHQA------------QLQEHIKEL-----LAIKQQQELLEKEQKLEQQRQEQEVER 117
+ +Q QA Q Q+H+ +L I+QQQ+ L++ +L+ Q+Q+Q+ ++
Sbjct: 196 MQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQQ 255
Query: 118 HRREQQ-----LPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRH 172
+++QQ PP++ + + S + Q+LQ+ + ++H
Sbjct: 256 QQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQM-----------HHTQHHQPPPQ 304
Query: 173 PKLWYTAAHHTSLDQSSPPLSGTSP--SYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRL 230
P+ A + S PP S T P S LPG + ++P LK R
Sbjct: 305 PQQPPVAQNQPS---QLPPQSQTQPLVSQAQALPG----------QMLYTQPPLKF-VRA 350
Query: 231 KQKVAERRSSPLLRRKDGNVVTSFKKRM----FEVTESS---VSSSSPGSGPSSPNNGPT 283
V + P ++++ V T+ +M +V++SS +SS SPG +P +
Sbjct: 351 PMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQS--- 407
Query: 284 GSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNA 343
+PP P Q +S N++ G PS
Sbjct: 408 ----------MPPPPQPSPQPGQP---------------SSQPNSNVSSGPAPSPSSFLP 442
Query: 344 SNSLKEKQKCETQTLRQ--GVPLPGQYGGSIPASS 376
S S + Q T Q VP PG + SS
Sbjct: 443 SPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSS 477
Score = 39.7 bits (91), Expect = 0.015
Identities = 100/483 (20%), Positives = 168/483 (34%), Gaps = 114/483 (23%)
Query: 34 MPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAI 93
M VV + QLQ + + +QQQQQ Q +FQ+Q + +Q Q Q
Sbjct: 141 MAVVSTATPQTQLQLQQVALQQQQQQQ------QFQQQQQAALQQQQQQ----------- 183
Query: 94 KQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLS 153
QQQ+ + +Q QQ+ + V++ +QQL + +Q+ Q+ L+
Sbjct: 184 -QQQQQFQAQQSAMQQQFQAVVQQ---QQQL-----------------QQQQQQQQHLIK 222
Query: 154 KSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDF 213
+ + R +L L Q + L AQ
Sbjct: 223 LHHQNQQQIQQQQQQLQRIAQL--------QLQQQQQQQQQQQQQQQQALQ-AQPPIQQP 273
Query: 214 PLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGS 273
P+++ P+ + +L+Q + P
Sbjct: 274 PMQQPQPPPSQALPQQLQQMHHTQHHQP-------------------------------- 301
Query: 274 GPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLG 333
P P P V +N+ S LPP + +VSQ + L + LYT P L +
Sbjct: 302 -PPQPQQPP---VAQNQPSQLPPQSQTQPLVSQAQALPGQ------MLYTQPPLKFVRA- 350
Query: 334 LPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQY--GGSIPASSSHPHVTLEGKPPNSS 391
P V Q ++++Q + PG S+P SS P + + P S
Sbjct: 351 -PMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSS-PSPGQQVQTPQSM 408
Query: 392 HQALLQHLLLKEQMRQQKLLVAGGVPLHPQS------PLATKERISPGIRGTHKLPRHRP 445
+ Q V+ G P S P ++ ++ +P P
Sbjct: 409 PPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGP 468
Query: 446 LNRTQSAPLPQSTLAQLVIQQ-QHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEE 504
LN + P S ++ Q + QQ+L+K KQ LSK IE L++ + +++
Sbjct: 469 LNTPVN---PSSVMSPAGSSQAEEQQYLDKLKQ----------LSKYIEPLRRMINKIDK 515
Query: 505 AEE 507
E+
Sbjct: 516 NED 518
Score = 37.0 bits (84), Expect = 0.099
Identities = 46/221 (20%), Positives = 86/221 (38%), Gaps = 23/221 (10%)
Query: 436 GTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQ--FLEKQK---QYQQQIHMNKLLSK 490
GT + H + + P Q L Q+ +QQQ QQ F ++Q+ Q QQQ +
Sbjct: 132 GTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQA 191
Query: 491 SIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEE 550
++Q + + +++LQ Q Q+ + + L ++ ++++++
Sbjct: 192 QQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQ--QQQLQRIAQLQLQQQ 249
Query: 551 PVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTH 610
+ Q Q+ Q Q P +P + P A+ + H ++ H
Sbjct: 250 QQQQQQQQQQQQQALQAQPPIQQPPMQQP--------QPPPSQALPQQLQQMHH--TQHH 299
Query: 611 SSPAASVLPHPAMDRP--LQPGSATGIAYDPLMLKHQCVCG 649
P P A ++P L P S T PL+ + Q + G
Sbjct: 300 QPPPQPQQPPVAQNQPSQLPPQSQT----QPLVSQAQALPG 336
>gi|17017963 forkhead box P2 isoform I [Homo sapiens]
Length = 715
Score = 55.1 bits (131), Expect = 4e-07
Identities = 48/187 (25%), Positives = 90/187 (48%), Gaps = 17/187 (9%)
Query: 23 PLDLRTDLRMMMP-VVDPVVREKQLQQELL-------LIQQQQQI--QKQLLIAEFQKQH 72
PL + + MM P V+ P ++ LQQ++L L+QQQQ + Q+Q L ++KQ
Sbjct: 84 PLQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQ 143
Query: 73 ENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDR 132
E L Q Q Q+ + QQQ+ +++Q+ +QQ+Q+Q+ ++ +++QQ GK
Sbjct: 144 EQLHLQLLQQQQQQQQ------QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQA 197
Query: 133 GRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVS-RHPKLWYTAAHHTSLDQSSPP 191
++ + + Q+ + + + + H +S + L +L S P
Sbjct: 198 KEQQQQQQQQQQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLP 257
Query: 192 LSGTSPS 198
+G SP+
Sbjct: 258 QAGLSPA 264
Score = 40.0 bits (92), Expect = 0.012
Identities = 49/236 (20%), Positives = 98/236 (41%), Gaps = 13/236 (5%)
Query: 424 LATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIH 483
+ T + I+P + ++ + + L+ Q L Q A ++ QQQ Q+F +KQ Q+Q+H
Sbjct: 93 MMTPQVITP--QQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQ---QEQLH 147
Query: 484 MNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVG 543
+ L + +Q +Q ++ +++ Q Q Q+ + A Q
Sbjct: 148 LQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQ 207
Query: 544 AVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFL--EPTHTRALSVRQAPLAAVGMDGLE 601
++ V + Q+Q+++ + +Q+ L P AL V+ P A + ++
Sbjct: 208 QQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQ 267
Query: 602 K-HRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIA----YDPLMLKHQCVCGNST 652
+ + V+ HS + H +D S+T + P + H V G S+
Sbjct: 268 QLWKEVTGVHSMEDNGI-KHGGLDLTTNNSSSTTSSNTSKASPPITHHSIVNGQSS 322
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 53.9 bits (128), Expect = 8e-07
Identities = 44/199 (22%), Positives = 95/199 (47%), Gaps = 17/199 (8%)
Query: 43 EKQLQQELL---LIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQEL 99
EK+L+QE L ++Q++ + QLL E +++ + L R+ + +L++ +K +++ E
Sbjct: 555 EKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLK-----REEVER 609
Query: 100 LEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKD 159
LE+E++ EQ+ + +E E RR+Q L ++R R++ + + +++ Q + +
Sbjct: 610 LEQEERREQRLKREEPEEERRQQLLKSEEQEER-RQQQLRREQQERREQRLKREEEEERL 668
Query: 160 TPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTA 219
+ H R + +Q+ + P +++ L DA+ K
Sbjct: 669 EQRLKREHEEERREQ----ELAEEEQEQARERIKSRIPKWQWQLESEADARQS----KVY 720
Query: 220 SEPNLKVRSRLKQKVAERR 238
S P + R +Q+ E+R
Sbjct: 721 SRPRKQEGQRRRQEQEEKR 739
Score = 50.1 bits (118), Expect = 1e-05
Identities = 40/117 (34%), Positives = 66/117 (56%), Gaps = 10/117 (8%)
Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101
RE+QL++E L ++QQ ++Q L E Q + E R+ Q +E +E K +QE E
Sbjct: 385 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERRE 444
Query: 102 KEQKLEQQ------RQEQEVERH---RREQQLPPLRGKDRGRERAVASTEVKQKLQE 149
+ K EQ+ ++E+E ERH RR+QQL + ++R RER + E +++ Q+
Sbjct: 445 QRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEER-RERWLKLEEEERREQQ 500
Score = 49.7 bits (117), Expect = 1e-05
Identities = 27/83 (32%), Positives = 54/83 (65%), Gaps = 1/83 (1%)
Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQ-KQHENLTRQHQAQLQEHIKELLAIKQQQELL 100
RE+QL++E L ++QQ ++Q L E Q ++ + L R+ Q + ++ ++ ++++QE
Sbjct: 373 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEE 432
Query: 101 EKEQKLEQQRQEQEVERHRREQQ 123
EQK EQ+R+EQ ++R + E++
Sbjct: 433 RHEQKHEQERREQRLKREQEERR 455
Score = 47.0 bits (110), Expect = 1e-04
Identities = 37/129 (28%), Positives = 67/129 (51%), Gaps = 18/129 (13%)
Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101
RE+QL++E L ++QQ ++Q QK + Q + QE ++ L +++ E E
Sbjct: 409 REQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHE 468
Query: 102 KEQKLEQQRQEQEVER----------------HRREQQLPPLRGKDRGRERAVASTEVKQ 145
+E++ +Q +++QE ER RREQQL R ++ RE+ + E ++
Sbjct: 469 QERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQL--RREQEERREQRLKRQEEEE 526
Query: 146 KLQEFLLSK 154
+LQ+ L S+
Sbjct: 527 RLQQRLRSE 535
Score = 44.7 bits (104), Expect = 5e-04
Identities = 29/111 (26%), Positives = 66/111 (59%), Gaps = 5/111 (4%)
Query: 43 EKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIK--ELLAIKQQQELL 100
E++LQ+E Q++ Q +++ L + ++Q RQ + Q Q+ ++ + L KQ++E
Sbjct: 257 EEKLQEEEPQRQRELQEEEEQL-RKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERR 315
Query: 101 EKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFL 151
E++++ +Q++ +E + RREQQL R ++ RE+ + + +++ ++ L
Sbjct: 316 EQQEERREQQERREQQEERREQQL--RREQEERREQQLRREQEEERREQQL 364
Score = 44.3 bits (103), Expect = 6e-04
Identities = 37/211 (17%), Positives = 96/211 (45%), Gaps = 21/211 (9%)
Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQ--KQHENLTRQHQAQLQEHIKELLAIKQQQEL 99
RE+QL++E +++QQ++++ + Q ++ + L R+ Q + ++ ++ ++++Q+L
Sbjct: 360 REQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 419
Query: 100 LEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKD 159
++Q +Q +E+ ++H +E++ L+ + R + E ++ ++ + +D
Sbjct: 420 RREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRD 479
Query: 160 TPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTA 219
+ W +Q + L Q+ + + L++
Sbjct: 480 QEEERRER--------WLKLEEEERREQQE--------RREQQLRREQEERREQRLKRQE 523
Query: 220 SEPNLKVRSRLKQKV---AERRSSPLLRRKD 247
E L+ R R +Q++ E R LL+R++
Sbjct: 524 EEERLQQRLRSEQQLRREQEERREQLLKREE 554
Score = 43.9 bits (102), Expect = 8e-04
Identities = 32/131 (24%), Positives = 72/131 (54%), Gaps = 7/131 (5%)
Query: 19 EPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQ 78
EP +L+ + + + +R ++ ++E QQQQ+++++ + Q++ ++
Sbjct: 264 EPQRQRELQEEEEQLRKLERQELRRERQEEE----QQQQRLRREQQLRRKQEEERREQQE 319
Query: 79 HQAQLQEHIKELLAIKQQQELLEKEQKLEQQ-RQEQEVERHRREQQLPPLRGKDRGRERA 137
+ + QE ++ ++QQ E+E++ EQQ R+EQE ER REQQL + ++R ++
Sbjct: 320 ERREQQERREQQEERREQQLRREQEERREQQLRREQEEER--REQQLRREQEEERREQQL 377
Query: 138 VASTEVKQKLQ 148
+++++ Q
Sbjct: 378 RREQQLRREQQ 388
Score = 43.9 bits (102), Expect = 8e-04
Identities = 32/113 (28%), Positives = 65/113 (57%), Gaps = 8/113 (7%)
Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101
R+++LQ+E +Q +++++Q L E Q++ + R + Q +E +QQ+E E
Sbjct: 267 RQRELQEEE---EQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERRE 323
Query: 102 KEQKLEQQ--RQEQEVERH---RREQQLPPLRGKDRGRERAVASTEVKQKLQE 149
++++ EQQ R+EQ++ R RREQQL + ++R ++ E +++ Q+
Sbjct: 324 QQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQ 376
Score = 43.1 bits (100), Expect = 0.001
Identities = 35/139 (25%), Positives = 71/139 (51%), Gaps = 33/139 (23%)
Query: 44 KQLQQELLLIQQQQQIQKQLLIAEFQKQHE--NLTRQHQAQLQEHIKELLAIKQ------ 95
++ ++E +Q++QQ+++Q L +F+++ + T Q Q + QE +++L +Q
Sbjct: 1701 RRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPERE 1760
Query: 96 QQEL--------LEKEQKLEQQRQEQEVE---------------RHRREQQLPPLR--GK 130
+Q+L +E++L Q+R+EQ++ + R EQQL P + GK
Sbjct: 1761 EQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGK 1820
Query: 131 DRGRERAVASTEVKQKLQE 149
R E + E +Q+L++
Sbjct: 1821 YRWEEEQLQLEEQEQRLRQ 1839
Score = 42.0 bits (97), Expect = 0.003
Identities = 27/123 (21%), Positives = 69/123 (56%), Gaps = 10/123 (8%)
Query: 42 REKQL--QQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQEL 99
RE++L Q+E +QQ+ + ++QL + +++ + L R+ + +L++ +E ++Q+E
Sbjct: 515 REQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEER 574
Query: 100 LEKEQKLEQQRQEQEVERHRRE--------QQLPPLRGKDRGRERAVASTEVKQKLQEFL 151
++ K E++R++Q ++R + E +++ L ++R +R +++ Q+ L
Sbjct: 575 RDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLL 634
Query: 152 LSK 154
S+
Sbjct: 635 KSE 637
Score = 42.0 bits (97), Expect = 0.003
Identities = 26/85 (30%), Positives = 56/85 (65%), Gaps = 6/85 (7%)
Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQH-ENLTRQH--QAQLQEHIKELLAIKQQQE 98
R ++L+++ ++ QQ ++QLL E +K+ + L RQ+ + +LQ+ ++LL +Q++
Sbjct: 1132 RRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKR 1191
Query: 99 LLEKEQKLEQQRQEQEVERHRREQQ 123
E+E+ Q R+E+E++R +R+Q+
Sbjct: 1192 RQERER---QYREEEELQRQKRKQR 1213
Score = 41.6 bits (96), Expect = 0.004
Identities = 27/98 (27%), Positives = 62/98 (63%), Gaps = 10/98 (10%)
Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101
RE+QL++E +++QQ++++ E +++ + L R+ Q + ++ ++ ++++Q+L
Sbjct: 347 REQQLRREQEEERREQQLRRE---QEEERREQQLRREQQLRREQQLRREQQLRREQQL-R 402
Query: 102 KEQKLEQQRQEQEVERH---RREQQLPPLRGKDRGRER 136
+EQ+L R+EQ++ R RREQQL + ++R ++
Sbjct: 403 REQQL---RREQQLRREQQLRREQQLRREQEEERHEQK 437
Score = 41.6 bits (96), Expect = 0.004
Identities = 28/109 (25%), Positives = 67/109 (61%), Gaps = 15/109 (13%)
Query: 54 QQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQ---------QELL--EK 102
+QQ++ ++QL + +++ + L RQ + +E +++ L +QQ ++LL E+
Sbjct: 498 EQQERREQQLRREQEERREQRLKRQEE---EERLQQRLRSEQQLRREQEERREQLLKREE 554
Query: 103 EQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFL 151
E++LEQ+R+EQ ++R + E++ L+ ++ R++ + E +++L++ L
Sbjct: 555 EKRLEQERREQRLKREQEERRDQLLKREEERRQQRL-KREQEERLEQRL 602
Score = 41.6 bits (96), Expect = 0.004
Identities = 25/100 (25%), Positives = 59/100 (59%), Gaps = 5/100 (5%)
Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKE----LLAIKQQQ 97
RE++ +Q+ L +Q+++++++L E ++ + R+ + + +E +E LL ++Q+
Sbjct: 581 REEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQE 640
Query: 98 ELLEKEQKLEQQ-RQEQEVERHRREQQLPPLRGKDRGRER 136
E +++ + EQQ R+EQ ++R E++L ++ ER
Sbjct: 641 ERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEER 680
Score = 41.6 bits (96), Expect = 0.004
Identities = 32/120 (26%), Positives = 69/120 (57%), Gaps = 13/120 (10%)
Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101
R+ + +++LL +++QQ+ +Q +F ++ + L RQ + + +EL + + +++ LE
Sbjct: 1461 RKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFRE-QELRSQEPERKFLE 1519
Query: 102 KEQKLEQQR-------QEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSK 154
+EQ+L +Q+ +EQ++ R R QQ R +DR R + +++Q+ +E LS+
Sbjct: 1520 EEQQLHRQQRQRKFLQEEQQLRRQERGQQ----RRQDRDR-KFREEEQLRQEREEQQLSR 1574
Score = 41.6 bits (96), Expect = 0.004
Identities = 27/114 (23%), Positives = 59/114 (51%), Gaps = 11/114 (9%)
Query: 38 DPVVREKQLQQ---ELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIK 94
D RE++L+ E ++++QQ+ +Q +F ++ + L RQ + Q + +
Sbjct: 1500 DRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRR--------Q 1551
Query: 95 QQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQ 148
+ +E++L Q+R+EQ++ R R+++ K R +E+ E +Q+L+
Sbjct: 1552 DRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLR 1605
Score = 40.8 bits (94), Expect = 0.007
Identities = 25/91 (27%), Positives = 54/91 (59%), Gaps = 6/91 (6%)
Query: 47 QQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKL 106
++E L +++Q+Q +Q +++ + E Q +++ +E +EL ++Q+ E+E+KL
Sbjct: 1824 EEEQLQLEEQEQRLRQERDRQYRAE-EQFATQEKSRREE--QELWQEEEQKRRQERERKL 1880
Query: 107 EQQ---RQEQEVERHRREQQLPPLRGKDRGR 134
++ RQ++E +RHR+ ++ GK GR
Sbjct: 1881 REEHIRRQQKEEQRHRQVGEIKSQEGKGHGR 1911
Score = 40.4 bits (93), Expect = 0.009
Identities = 34/125 (27%), Positives = 64/125 (51%), Gaps = 12/125 (9%)
Query: 45 QLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHI-KELLAIKQQQELLEKE 103
Q QE Q+Q++ QK E +++ T + LQE + KE +++++E L++E
Sbjct: 857 QEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQRE 916
Query: 104 QKLEQQRQEQEVERHRREQQLPP----------LRGKDRGRERAVASTEVKQKLQEFLLS 153
++ +++RQEQE ++R E+QL + + + RER + Q+ +E LL
Sbjct: 917 EREKRRRQEQE-RQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLG 975
Query: 154 KSATK 158
+ K
Sbjct: 976 EEPEK 980
Score = 40.4 bits (93), Expect = 0.009
Identities = 36/119 (30%), Positives = 69/119 (57%), Gaps = 12/119 (10%)
Query: 42 REKQLQQELLLIQQ--QQQIQKQLLIAEFQKQHENLTRQHQAQ--LQEHIKELLAIKQQQ 97
R+++ ++E L+Q+ +QQ+++Q +F+++ + L RQ + + LQE ++L + ++
Sbjct: 1665 RDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEE-QQLRRQELER 1723
Query: 98 ELLEKEQKLEQQRQEQ--EVERHRR---EQQLPPLRGKD--RGRERAVASTEVKQKLQE 149
+ E+EQ ++ QEQ ER+R+ E+QL P R + R +ER E +Q QE
Sbjct: 1724 KFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQE 1782
Score = 40.0 bits (92), Expect = 0.012
Identities = 27/109 (24%), Positives = 60/109 (55%), Gaps = 2/109 (1%)
Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQH-QAQLQEHIKELLAIKQQQELL 100
RE L++E +Q+++ Q+Q + E ++Q L RQ + + QE ++ ++++Q+L
Sbjct: 249 RETVLRKEEEKLQEEEP-QRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLR 307
Query: 101 EKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149
K+++ +++QE+ E+ R +Q R + RE+ + ++ QE
Sbjct: 308 RKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQE 356
Score = 39.7 bits (91), Expect = 0.015
Identities = 34/125 (27%), Positives = 70/125 (56%), Gaps = 19/125 (15%)
Query: 43 EKQLQQELLLI------QQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIK-- 94
E+QL++ LL +++QQ +++ FQ++ E R+ + L++ ++L +
Sbjct: 207 EEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQ 266
Query: 95 QQQELLEKEQKL----------EQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVK 144
+Q+EL E+E++L E+Q +EQ+ +R RREQQL + ++R RE+ E +
Sbjct: 267 RQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEER-REQQEERREQQ 325
Query: 145 QKLQE 149
++ ++
Sbjct: 326 ERREQ 330
Score = 39.7 bits (91), Expect = 0.015
Identities = 23/83 (27%), Positives = 52/83 (62%), Gaps = 9/83 (10%)
Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101
RE+Q ++E QQ+++ ++QL + +++ + L R+ + + +E ++++QE
Sbjct: 322 REQQERRE----QQEERREQQLRREQEERREQQLRREQEEERREQ-----QLRREQEEER 372
Query: 102 KEQKLEQQRQEQEVERHRREQQL 124
+EQ+L +++Q + ++ RREQQL
Sbjct: 373 REQQLRREQQLRREQQLRREQQL 395
Score = 39.7 bits (91), Expect = 0.015
Identities = 33/135 (24%), Positives = 66/135 (48%), Gaps = 25/135 (18%)
Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQA--------------QLQEHI 87
+ ++ ++EL +++++Q+Q++ + Q++ + L + QL+E
Sbjct: 823 QRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEER 882
Query: 88 KE----LLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEV 143
K L A QE L KEQ+L Q+ +E+E++R RE++ + + +ER E
Sbjct: 883 KRRRHTLYAKPALQEQLRKEQQLLQE-EEEELQREEREKR------RRQEQERQYREEEQ 935
Query: 144 KQKLQEFLLSKSATK 158
Q+ +E LL + K
Sbjct: 936 LQQEEEQLLREEREK 950
Score = 39.7 bits (91), Expect = 0.015
Identities = 29/123 (23%), Positives = 66/123 (53%), Gaps = 9/123 (7%)
Query: 38 DPVVREKQLQQELL-LIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEH--IKELLAIK 94
D +R++Q QQ+L L+ +QQ+ ++ +Q++ + + Q + +E K
Sbjct: 1255 DSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKS 1314
Query: 95 QQQELLEKEQKLEQQRQEQEVERHRREQQL------PPLRGKDRGRERAVASTEVKQKLQ 148
Q+++ L +E++ E++R+++ + R E+QL PLR ++R R+ +++ +
Sbjct: 1315 QEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGR 1374
Query: 149 EFL 151
+FL
Sbjct: 1375 KFL 1377
Score = 39.7 bits (91), Expect = 0.015
Identities = 29/120 (24%), Positives = 63/120 (52%), Gaps = 16/120 (13%)
Query: 42 REKQLQQEL--LLIQQQQQIQKQLLIAEFQKQHENLTRQH----------QAQLQEHIKE 89
RE+QL+Q+ +++QQ+ +Q +F+++ + + RQ Q + + H K
Sbjct: 1404 REQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRK- 1462
Query: 90 LLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149
+++++LL++ ++ + RQE++ + EQQL + RE+ + S E ++K E
Sbjct: 1463 ---FREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLE 1519
Score = 39.3 bits (90), Expect = 0.020
Identities = 23/81 (28%), Positives = 47/81 (58%), Gaps = 2/81 (2%)
Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101
R++QL++E ++Q++ +++ +AE ++Q E R Q Q +EL +Q+QE E
Sbjct: 125 RDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELW--RQRQEWQE 182
Query: 102 KEQKLEQQRQEQEVERHRREQ 122
+E++ ++ Q Q + H E+
Sbjct: 183 REERRAEEEQLQSCKGHETEE 203
Score = 39.3 bits (90), Expect = 0.020
Identities = 32/112 (28%), Positives = 60/112 (53%), Gaps = 8/112 (7%)
Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQ--EHIKELLAIKQQQEL 99
RE+QL+ E ++QQ+ Q+ L E ++Q R+ + +LQ E ++L ++ Q+L
Sbjct: 794 RERQLRAE----ERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQL 849
Query: 100 LEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFL 151
E+E L++ ++ + + RR+Q+ ++R R R + K LQE L
Sbjct: 850 QEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRR--HTLYAKPALQEQL 899
Score = 39.3 bits (90), Expect = 0.020
Identities = 30/129 (23%), Positives = 69/129 (53%), Gaps = 20/129 (15%)
Query: 39 PVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQE 98
P ++E+ +++ LL ++++++Q++ + E RQ Q + +E ++Q++E
Sbjct: 893 PALQEQLRKEQQLLQEEEEELQRE--------EREKRRRQEQ---ERQYREEEQLQQEEE 941
Query: 99 LLEKEQKLEQQRQEQEVERHR------REQQL---PPLRGKDRGRERAVASTEVKQKLQE 149
L +E++ +++RQE+E + + +E+QL P + + + RE+ E Q+ +E
Sbjct: 942 QLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEE 1001
Query: 150 FLLSKSATK 158
LL + K
Sbjct: 1002 QLLREEREK 1010
Score = 39.3 bits (90), Expect = 0.020
Identities = 33/125 (26%), Positives = 66/125 (52%), Gaps = 14/125 (11%)
Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101
R ++L+++ ++ QQ ++QLL E +K+ R+ Q + +E +++ ++++LL
Sbjct: 1072 RRQELERQYRKEEELQQEEEQLLREEPEKRRRQ-ERERQCREEEELQQ-----EEEQLLR 1125
Query: 102 KE------QKLEQQRQEQEVERHRREQQL--PPLRGKDRGRERAVASTEVKQKLQEFLLS 153
+E Q+LE+Q +E+E + EQ L P + + + ER E Q+ +E LL
Sbjct: 1126 EEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLR 1185
Query: 154 KSATK 158
+ K
Sbjct: 1186 EEQEK 1190
Score = 38.9 bits (89), Expect = 0.026
Identities = 26/88 (29%), Positives = 54/88 (61%), Gaps = 5/88 (5%)
Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101
RE+QL+++ +++QQ +++ ++Q E +Q + + +E ++ L +Q++E E
Sbjct: 302 REQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERRE 361
Query: 102 KEQKLEQQ--RQEQEVERH---RREQQL 124
++ + EQ+ R+EQ++ R RREQQL
Sbjct: 362 QQLRREQEEERREQQLRREQQLRREQQL 389
Score = 38.9 bits (89), Expect = 0.026
Identities = 22/107 (20%), Positives = 60/107 (56%), Gaps = 2/107 (1%)
Query: 43 EKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEK 102
+++ +Q+L Q++++ ++ L + E +++ + R+ Q + ++ + +K+Q+E
Sbjct: 469 QERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERL 528
Query: 103 EQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149
+Q+L ++Q + + RREQ L R +++ E+ +K++ +E
Sbjct: 529 QQRLRSEQQLRREQEERREQLLK--REEEKRLEQERREQRLKREQEE 573
Score = 38.9 bits (89), Expect = 0.026
Identities = 31/123 (25%), Positives = 66/123 (53%), Gaps = 15/123 (12%)
Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIK-------ELLAIK 94
R+ Q +++LL +++++ ++Q +F+++ + L + + L+ + EL +
Sbjct: 1312 RKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQE 1371
Query: 95 QQQELLEKEQKLEQQ-------RQEQEVERHRREQQLPPLRG-KDRGRERAVASTEVKQK 146
Q ++ LE+EQ+L +Q ++EQ++ REQQL R K R E+ ++ E +K
Sbjct: 1372 QGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRK 1431
Query: 147 LQE 149
+E
Sbjct: 1432 FRE 1434
Score = 38.5 bits (88), Expect = 0.034
Identities = 29/115 (25%), Positives = 61/115 (53%), Gaps = 4/115 (3%)
Query: 38 DPVVREKQL---QQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIK 94
D RE++L +Q ++++Q++++Q +F K+ + L Q + Q ++ +
Sbjct: 1359 DRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFRE 1418
Query: 95 QQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149
++Q+L +E+ + + +EQ+V R RE++ + R +ER E +Q LQE
Sbjct: 1419 EEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLR-QERHRKFREEEQLLQE 1472
Score = 38.1 bits (87), Expect = 0.045
Identities = 26/108 (24%), Positives = 60/108 (55%), Gaps = 2/108 (1%)
Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101
+E++ QQE QQ ++ Q++ + +++ E R+ Q + ++ + ++++ L
Sbjct: 325 QERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLR 384
Query: 102 KEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149
+EQ+L +++Q + ++ RREQQL R + RE+ + + ++ QE
Sbjct: 385 REQQLRREQQLRREQQLRREQQL--RREQQLRREQQLRREQQLRREQE 430
Score = 38.1 bits (87), Expect = 0.045
Identities = 32/107 (29%), Positives = 59/107 (55%), Gaps = 7/107 (6%)
Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQH-ENLTRQHQAQLQEHIKELLAIKQQQELL 100
RE+Q ++E ++ QQ ++QLL E +K+ + L RQ++ + + +E ++++ E
Sbjct: 1106 RERQCREE----EELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEK- 1160
Query: 101 EKEQKLEQQRQEQEVERHRREQQLPPLRGKDR-GRERAVASTEVKQK 146
+ Q+LE+Q +E+E + EQ L + K R RER E Q+
Sbjct: 1161 RRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQR 1207
Score = 37.7 bits (86), Expect = 0.058
Identities = 23/107 (21%), Positives = 58/107 (54%), Gaps = 1/107 (0%)
Query: 44 KQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQ-QELLEK 102
++ +QE ++ +QQ+++Q + +++ + R+ + LQE ++ L +++ ++ LE+
Sbjct: 1589 RRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEE 1648
Query: 103 EQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149
E +L +Q +EQ++ R + + G E+ + E +K +E
Sbjct: 1649 EPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFRE 1695
Score = 37.7 bits (86), Expect = 0.058
Identities = 28/116 (24%), Positives = 58/116 (50%), Gaps = 8/116 (6%)
Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKE--------LLAI 93
R+ + ++LL +++QQ+ +Q +F ++ L RQ + Q H ++ LL
Sbjct: 1619 RKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQE 1678
Query: 94 KQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149
++Q+L +E+ + + +EQ++ R RE++ + R +E E +Q QE
Sbjct: 1679 GEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQE 1734
Score = 37.4 bits (85), Expect = 0.076
Identities = 31/121 (25%), Positives = 61/121 (50%), Gaps = 12/121 (9%)
Query: 43 EKQLQQELLLIQQQQQIQK-QLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101
E++ +QEL +Q+Q ++ + I ++Q Q E+ Q+++ ++ +++QE E
Sbjct: 678 EERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEE 737
Query: 102 KEQKLEQQRQEQEVERHRREQQLPPLR-----------GKDRGRERAVASTEVKQKLQEF 150
K ++ E + Q QE ER R+QQ R +RGR+R A ++++ +
Sbjct: 738 KRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQ 797
Query: 151 L 151
L
Sbjct: 798 L 798
Score = 37.0 bits (84), Expect = 0.099
Identities = 23/91 (25%), Positives = 55/91 (60%), Gaps = 5/91 (5%)
Query: 47 QQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQ-AQLQEHIKELLAIKQQQELLEKEQK 105
+++ L Q+++Q +Q +F+++ + L+RQ + + +E +++ +++++ LE+EQ+
Sbjct: 1395 EEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQ 1454
Query: 106 LEQQR----QEQEVERHRREQQLPPLRGKDR 132
L Q+R +E+E RE+Q + +DR
Sbjct: 1455 LRQERHRKFREEEQLLQEREEQQLHRQERDR 1485
Score = 37.0 bits (84), Expect = 0.099
Identities = 27/125 (21%), Positives = 59/125 (47%), Gaps = 15/125 (12%)
Query: 43 EKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEK 102
E+QL+QE +++QQ++ Q +++ + E L + Q Q ++ ++Q ++
Sbjct: 1800 EEQLRQE----REEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQE 1855
Query: 103 EQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPT 162
+ + E+Q QE E+ RR++ RER + ++++ +E + +
Sbjct: 1856 KSRREEQELWQEEEQKRRQE-----------RERKLREEHIRRQQKEEQRHRQVGEIKSQ 1904
Query: 163 NGKNH 167
GK H
Sbjct: 1905 EGKGH 1909
Score = 36.6 bits (83), Expect = 0.13
Identities = 27/102 (26%), Positives = 59/102 (57%), Gaps = 8/102 (7%)
Query: 27 RTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEH 86
R + R+ V+ + +E++ +Q L + +++ ++QLL +E +Q E +Q + + QE
Sbjct: 597 RLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSE--EQEERRQQQLRREQQER 654
Query: 87 IKELLAIKQQQELLEKEQKLE--QQRQEQEV----ERHRREQ 122
++ L ++++E LE+ K E ++R+EQE+ + RE+
Sbjct: 655 REQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARER 696
Score = 36.6 bits (83), Expect = 0.13
Identities = 32/122 (26%), Positives = 65/122 (53%), Gaps = 8/122 (6%)
Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQH-ENLTRQH--QAQLQEHIKELLAIKQQQE 98
R ++ +++ + QQ ++QLL E +K+ + RQ+ + +LQ+ ++LL +++
Sbjct: 1012 RRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETR 1071
Query: 99 LLEKEQKLEQQRQEQEVERHRREQQL--PPLRGKDRGRERAVASTEVKQKLQEFLLSKSA 156
+ Q+LE+Q +++E + EQ L P + + + RER E Q+ +E LL +
Sbjct: 1072 ---RRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREER 1128
Query: 157 TK 158
K
Sbjct: 1129 EK 1130
Score = 36.2 bits (82), Expect = 0.17
Identities = 22/77 (28%), Positives = 47/77 (61%), Gaps = 1/77 (1%)
Query: 47 QQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKL 106
++ LL ++Q++ Q++ + Q + E R+ Q + QE +EL ++Q E E+ ++
Sbjct: 106 KESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKR-QEQERELAEGEEQSEKQERLEQR 164
Query: 107 EQQRQEQEVERHRREQQ 123
++QR+++E+ R R+E Q
Sbjct: 165 DRQRRDEELWRQRQEWQ 181
Score = 36.2 bits (82), Expect = 0.17
Identities = 32/131 (24%), Positives = 70/131 (53%), Gaps = 13/131 (9%)
Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQL---QEHIKELLAIKQQQE 98
RE+Q ++E L ++Q++ ++Q L + +++ + + QL QE +E L +++++
Sbjct: 497 REQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEK 556
Query: 99 LLEKEQ-----KLEQQRQEQEV---ERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEF 150
LE+E+ K EQ+ + ++ E RR+Q+L R ++ E+ + EV++ QE
Sbjct: 557 RLEQERREQRLKREQEERRDQLLKREEERRQQRLK--REQEERLEQRLKREEVERLEQEE 614
Query: 151 LLSKSATKDTP 161
+ ++ P
Sbjct: 615 RREQRLKREEP 625
Score = 36.2 bits (82), Expect = 0.17
Identities = 35/123 (28%), Positives = 69/123 (56%), Gaps = 14/123 (11%)
Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQH-ENLTRQHQA--QLQEHIKELLAIKQQQE 98
REK+ ++E ++ QQ ++QLL E +K+ + RQ++ +LQ+ ++LL ++++
Sbjct: 986 REKKYREE----EELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKR 1041
Query: 99 LLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGR---ERAVASTEVKQKLQEFLLSKS 155
L++ ++ Q R+E+E+++ E+QL + R R ER E Q+ +E LL +
Sbjct: 1042 RLQERER--QYREEEELQQ--EEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREE 1097
Query: 156 ATK 158
K
Sbjct: 1098 PEK 1100
Score = 35.8 bits (81), Expect = 0.22
Identities = 24/87 (27%), Positives = 49/87 (56%), Gaps = 15/87 (17%)
Query: 43 EKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEK 102
E+QL+QE +++QQ+ +Q +F+ + + + RQ Q ++ + +QQ E
Sbjct: 1560 EEQLRQE----REEQQLSRQERDRKFRLEEQKVRRQEQE------RKFMEDEQQLRRQEG 1609
Query: 103 EQKLEQQ-----RQEQEVERHRREQQL 124
+Q+L Q+ R+++++ + R EQQL
Sbjct: 1610 QQQLRQERDRKFREDEQLLQEREEQQL 1636
Score = 35.8 bits (81), Expect = 0.22
Identities = 28/127 (22%), Positives = 66/127 (51%), Gaps = 12/127 (9%)
Query: 40 VVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQL--QEHIKELLAIKQQQ 97
++ E+QL+ E +++QQ+++Q +F+++ + + + QL QE ++ +Q +
Sbjct: 1749 ILEEEQLRPE----REEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLR 1804
Query: 98 ELLEKEQKLEQQR------QEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFL 151
+ E++Q QQR +E++++ +EQ+L R + E A+ E ++ ++ L
Sbjct: 1805 QEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQEL 1864
Query: 152 LSKSATK 158
+ K
Sbjct: 1865 WQEEEQK 1871
Score = 35.4 bits (80), Expect = 0.29
Identities = 36/126 (28%), Positives = 64/126 (50%), Gaps = 20/126 (15%)
Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101
RE+Q ++E ++ QQ ++QLL E TR+ Q +L+ ++ ++Q++E L
Sbjct: 1046 RERQYREE----EELQQEEEQLL------GEERETRRRQ-ELERQYRKEEELQQEEEQLL 1094
Query: 102 KEQKLEQQRQE------QEVERHRREQQLPPLRGKDRGR---ERAVASTEVKQKLQEFLL 152
+E+ +++RQE +E E + E+QL + R R ER E Q+ +E LL
Sbjct: 1095 REEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLL 1154
Query: 153 SKSATK 158
+ K
Sbjct: 1155 REEPEK 1160
Score = 35.4 bits (80), Expect = 0.29
Identities = 25/111 (22%), Positives = 61/111 (54%), Gaps = 19/111 (17%)
Query: 44 KQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQL--QEHIKELLAIKQQQELLE 101
++ ++E ++++QQ++++ +F+++ + L + + QL QE ++ L +QQ E
Sbjct: 1440 RRQERERKFLEEEQQLRQERH-RKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQE 1498
Query: 102 KEQKLEQQ------------RQEQEVERHRRE----QQLPPLRGKDRGRER 136
+++K +Q +EQ++ R +R+ Q+ LR ++RG++R
Sbjct: 1499 RDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQR 1549
Score = 34.7 bits (78), Expect = 0.49
Identities = 38/128 (29%), Positives = 61/128 (47%), Gaps = 23/128 (17%)
Query: 42 REKQLQQELLLIQQQQQIQKQ--LLIAEFQKQHENLTRQHQ------------AQLQE-- 85
R+K+ +QE L + ++Q +KQ L + Q++ E L RQ Q QLQ
Sbjct: 138 RQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCK 197
Query: 86 -HIKELLAIKQQ---QELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVAST 141
H E ++Q +ELLE +K +++Q+Q ER R Q + R+R
Sbjct: 198 GHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQ---EEEEKEWRKRETVLR 254
Query: 142 EVKQKLQE 149
+ ++KLQE
Sbjct: 255 KEEEKLQE 262
Score = 34.7 bits (78), Expect = 0.49
Identities = 27/103 (26%), Positives = 53/103 (51%), Gaps = 11/103 (10%)
Query: 43 EKQLQQ----ELLLIQQQQQIQKQLLI-----AEFQKQHENLTRQHQAQLQEHIKELLAI 93
E+QLQ E ++Q++++ L+ +KQ + RQ + +E KE
Sbjct: 190 EEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWR-- 247
Query: 94 KQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRER 136
K++ L ++E+KL+++ +++ E E+QL L ++ RER
Sbjct: 248 KRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRER 290
Score = 34.7 bits (78), Expect = 0.49
Identities = 30/113 (26%), Positives = 61/113 (53%), Gaps = 10/113 (8%)
Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHE----NLTRQHQAQLQEHIKELLAIKQQQ 97
R L++E + +Q+ +KQ L + +++ L + + + QE ++ L +Q++
Sbjct: 454 RRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEE 513
Query: 98 ELLEKEQKLEQQRQEQEV-ERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149
+EQ+L++Q +E+ + +R R EQQL R ++ RE+ + E K+ QE
Sbjct: 514 ---RREQRLKRQEEEERLQQRLRSEQQL--RREQEERREQLLKREEEKRLEQE 561
Score = 34.7 bits (78), Expect = 0.49
Identities = 26/132 (19%), Positives = 69/132 (52%), Gaps = 7/132 (5%)
Query: 19 EPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQ 78
+P LR + +++ + + RE++ ++ ++Q + ++QL E Q E ++
Sbjct: 892 KPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKR 951
Query: 79 HQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAV 138
+ + + ++ ++Q++E L E+ +++RQE+E +++R E++L + E+ +
Sbjct: 952 RRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQERE-KKYREEEEL------QQEEEQLL 1004
Query: 139 ASTEVKQKLQEF 150
K++ QE+
Sbjct: 1005 REEREKRRRQEW 1016
Score = 34.7 bits (78), Expect = 0.49
Identities = 27/109 (24%), Positives = 59/109 (54%), Gaps = 7/109 (6%)
Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQH-ENLTRQHQAQLQEHIKELLAIKQQQELL 100
+E+Q ++E +Q QQ ++QLL E +K+ + RQ++ + KE + ++ E
Sbjct: 926 QERQYREE----EQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKR 981
Query: 101 EKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149
++++ ++ R+E+E+++ E+QL + R R+ K +LQ+
Sbjct: 982 RRQEREKKYREEEELQQ--EEEQLLREEREKRRRQEWERQYRKKDELQQ 1028
Score = 34.7 bits (78), Expect = 0.49
Identities = 29/130 (22%), Positives = 63/130 (48%), Gaps = 11/130 (8%)
Query: 29 DLRMMMPVVDPVVREKQL---QQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQE 85
+LR P + E+QL Q++ +Q++QQ+++Q + ++ + R+ + QE
Sbjct: 1507 ELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQE 1566
Query: 86 HIKELLAIKQQQELLE-KEQKLEQQRQE-------QEVERHRREQQLPPLRGKDRGRERA 137
++ L+ +++ +EQK+ +Q QE Q++ R +QQL R + +
Sbjct: 1567 REEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQ 1626
Query: 138 VASTEVKQKL 147
+ +Q+L
Sbjct: 1627 LLQEREEQQL 1636
Score = 33.9 bits (76), Expect = 0.84
Identities = 25/94 (26%), Positives = 48/94 (51%), Gaps = 8/94 (8%)
Query: 52 LIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQ 111
L+Q ++Q + Q +Q E Q + Q ++ +Q++EL E E++ E+Q +
Sbjct: 109 LLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQ--------EQERELAEGEEQSEKQER 160
Query: 112 EQEVERHRREQQLPPLRGKDRGRERAVASTEVKQ 145
++ +R RR+++L R + + RE A E Q
Sbjct: 161 LEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQ 194
Score = 33.9 bits (76), Expect = 0.84
Identities = 48/206 (23%), Positives = 89/206 (43%), Gaps = 31/206 (15%)
Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101
RE+Q +++ L QQ ++QLL E +K+ RQ + + +EL +Q++E L
Sbjct: 956 RERQYRKDKKL----QQKEEQLLGEEPEKRR----RQEREKKYREEEEL---QQEEEQLL 1004
Query: 102 KEQKLEQQRQEQEVERHRR-------EQQLPPLRGKDR--GRERAVASTEVKQKLQEFLL 152
+E++ +++RQE E + ++ EQ L R K R RER E Q+ +E LL
Sbjct: 1005 REEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLL 1064
Query: 153 SKSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDD 212
G+ R +L L Q L P + + +++
Sbjct: 1065 -----------GEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREE 1113
Query: 213 FPLRKTASEPNLKVRSRLKQKVAERR 238
L++ + + R + +++ ER+
Sbjct: 1114 EELQQEEEQLLREEREKRRRQELERQ 1139
Score = 33.5 bits (75), Expect = 1.1
Identities = 27/108 (25%), Positives = 60/108 (55%), Gaps = 7/108 (6%)
Query: 43 EKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEK 102
E Q ++E LL ++ ++ ++Q L +++++ E +Q + QL +E +++++ E+
Sbjct: 1145 EVQQEEEQLLREEPEKRRRQELERQYREEEE--LQQEEEQLLREEQEKRRQERERQYREE 1202
Query: 103 EQKLEQQRQEQEVERHRREQQLPPLRGK-DRGRERAVASTEVKQKLQE 149
E+ Q+R+ +R+R E Q L+ + + +E AV +V K +E
Sbjct: 1203 EELQRQKRK----QRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRE 1246
Score = 32.7 bits (73), Expect = 1.9
Identities = 38/124 (30%), Positives = 62/124 (50%), Gaps = 23/124 (18%)
Query: 42 REKQLQ-QELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQL-------QEHIKELLAI 93
RE +LQ QE +QQQ ++Q +Q Q E + + + +L ++ ++L A
Sbjct: 742 RESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAE 801
Query: 94 KQQQ-------ELLEKEQKLEQQRQ-EQEVERHRREQQLPPLRGKDRGRERAVASTEVKQ 145
++QQ E EKEQ+ Q+R+ E+E++ E+QL + RERA E +
Sbjct: 802 ERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQL-------QRRERAQQLQEEED 854
Query: 146 KLQE 149
LQE
Sbjct: 855 GLQE 858
Score = 30.8 bits (68), Expect = 7.1
Identities = 34/144 (23%), Positives = 71/144 (49%), Gaps = 21/144 (14%)
Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELL---------- 91
RE++L++E + +Q+++++ E +++ + L + Q Q +E IK +
Sbjct: 655 REQRLKREEEEERLEQRLKRE---HEEERREQELAEEEQEQARERIKSRIPKWQWQLESE 711
Query: 92 AIKQQQELLEKEQKLEQQRQEQEV-E-RHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149
A +Q ++ + +K E QR+ QE E R RRE +L + + ERA + +++ ++
Sbjct: 712 ADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESEL-----QWQEEERAHRQQQEEEQRRD 766
Query: 150 FLLSKSATKDTPTNGKNHSVSRHP 173
F A ++ G+ +R P
Sbjct: 767 FTWQWQA-EEKSERGRQRLSARPP 789
Score = 30.4 bits (67), Expect = 9.3
Identities = 28/146 (19%), Positives = 65/146 (44%), Gaps = 34/146 (23%)
Query: 43 EKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQA--------------------- 81
E++LQ++ + + + Q+ L +++ + EN R ++
Sbjct: 1202 EEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDR 1261
Query: 82 QLQEHIKELLAIKQQQEL-------------LEKEQKLEQQRQEQEVERHRREQQLPPLR 128
Q Q+ ++ LL +Q+++ +E++LE++ Q++ R R+ Q+ L
Sbjct: 1262 QSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLL 1321
Query: 129 GKDRGRERAVASTEVKQKLQEFLLSK 154
++R +R T+ K + +E LL +
Sbjct: 1322 REEREEKRRRQETDRKFREEEQLLQE 1347
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 53.9 bits (128), Expect = 8e-07
Identities = 68/273 (24%), Positives = 115/273 (42%), Gaps = 43/273 (15%)
Query: 43 EKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEK 102
E L++E L +QQ+ + + L KQ + L +Q Q + HIK LL +Q++ +K
Sbjct: 348 ESTLRREFLRLQQENKSNSEAL-----KQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQK 402
Query: 103 EQKL---EQQRQE------QEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLS 153
E++ EQQR+E QE E+ RR + + LR ++ R +A E K+K E
Sbjct: 403 EERRRVEEQQRREREQRKLQEKEQQRRLEDMQALR-REEERRQAEREQEYKRKQLE---- 457
Query: 154 KSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDF 213
+ S +L A+ SL Q + LPG + +
Sbjct: 458 ----------EQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHY 507
Query: 214 -----PLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVT---ESS 265
P K A ++ R+R+ ++++SPL + K G+ T + + + +
Sbjct: 508 GRGMNPADKPAWAREVEERTRMN----KQQNSPLAKSKPGS--TGPEPPIPQASPGPPGP 561
Query: 266 VSSSSPGSGPSSPNNGPTGSVTENETSVLPPTP 298
+S + P P P GP S+ + T L P
Sbjct: 562 LSQTPPMQRPVEPQEGPHKSLQDQPTRNLAAFP 594
Score = 34.7 bits (78), Expect = 0.49
Identities = 53/271 (19%), Positives = 109/271 (40%), Gaps = 30/271 (11%)
Query: 42 REKQLQQELLLIQQQQQIQKQL----LIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQ 97
R+ + + LL Q+Q++I++Q + E Q++ + + + Q ++++ A+++++
Sbjct: 381 RDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREE 440
Query: 98 ELLE-------KEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEF 150
E + K ++LE+QRQ + ++R + +Q+ L+ + +++ + QK Q+
Sbjct: 441 ERRQAEREQEYKRKQLEEQRQSERLQR-QLQQEHAYLKSLQQQQQQ-----QQLQKQQQQ 494
Query: 151 LLSKSATKDTPTNGKNHSVSRHP--------KLWYTAAHHTSLDQSSPPLSGTSPSYKYT 202
L K G+ + + P + ++ L +S P +G P
Sbjct: 495 QLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQA 554
Query: 203 LPGAQDAKDDFPLRKTASEPNLKVRSRLK-QKVAERRSSPLLRRKDGNV--VTSFKKRMF 259
PG P + EP L+ Q + P D + T+
Sbjct: 555 SPGPPGPLSQTPPMQRPVEPQEGPHKSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARG 614
Query: 260 EVTESSVSSSSPGSGPSSPNNGPTGSVTENE 290
V + +S G GPS N P +NE
Sbjct: 615 AVIRQNSDPTSEGPGPSP--NPPAWVRPDNE 643
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 52.0 bits (123), Expect = 3e-06
Identities = 48/178 (26%), Positives = 84/178 (47%), Gaps = 18/178 (10%)
Query: 39 PVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQE 98
P+ +QLQQ+ L QQQQQ+Q+Q Q+Q + + Q QLQ+ ++ +QQQ+
Sbjct: 3893 PMGSLQQLQQQQQL-QQQQQLQQQQ-----QQQLQQQQQLQQQQLQQQQQQQQLQQQQQQ 3946
Query: 99 LLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQK-----------L 147
L+++Q+ QQ+Q+Q+ ++ +++QQ + ++ R + +Q+ L
Sbjct: 3947 QLQQQQQQLQQQQQQQQQQFQQQQQQQQMGLLNQSRTLLSPQQQQQQQVALGPGMPAKPL 4006
Query: 148 QEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPG 205
Q F + GK + + P + A S Q P GT+P T PG
Sbjct: 4007 QHFSSPGALGPTLLLTGKEQN-TVDPAVSSEATEGPSTHQGGPLAIGTTPESMATEPG 4063
Score = 44.3 bits (103), Expect = 6e-04
Identities = 139/660 (21%), Positives = 236/660 (35%), Gaps = 137/660 (20%)
Query: 43 EKQLQQELLLIQQQQQIQKQL-LIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101
E ++ L+ +QQ +IQKQL + + QK+H NL +++ KQQQ+
Sbjct: 3558 EADAEKLKLVTEQQSKIQKQLDQVRKQQKEHTNLMAEYRN------------KQQQQ--- 3602
Query: 102 KEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTP 161
+Q+ +QQ+Q+ Q P L K G+ + Q + TP
Sbjct: 3603 -QQQQQQQQQQHSAVLALSPSQSPRLLTKLPGQLLPGHGLQPPQGPPGG--QAGGLRLTP 3659
Query: 162 TNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASE 221
P L A S S PS + PG + P + E
Sbjct: 3660 GGMALPGQPGGPFLNTALAQQQQQQHSGGAGSLAGPSGGF-FPGNLALRSLGPDSRLLQE 3718
Query: 222 PNLKV---RSRLKQKVAERRSSPLLRRKD-GNVVTSFKKRMFEVTESSVSSSSPGSG--- 274
L++ R +L QK+ +++ ++ G V +++ +++ + G
Sbjct: 3719 RQLQLQQQRMQLAQKLQQQQQQQQQQQHLLGQVAIQQQQQQGPGVQTNQALGPKPQGLMP 3778
Query: 275 PSS------------PNNGPTGSVTENETSVL---------PPTPHAEQMVSQQRILIHE 313
PSS P GP G + + +VL P PH + +++Q R+L
Sbjct: 3779 PSSHQGLLVQQLSPQPPQGPQGMLGPAQVAVLQQQHPGALGPQGPHRQVLMTQSRVL--- 3835
Query: 314 DSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQYGGSIP 373
+SP L GL + +L + +++Q+ + Q G+ Q S+
Sbjct: 3836 ---------SSPQLAQQGQGL--MGHRLVTAQQQQQQQQHQQQGSMAGLSHLQQ---SLM 3881
Query: 374 ASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPG 433
+ S P L +P S Q Q L ++Q QQ+ Q L ++++
Sbjct: 3882 SHSGQPK--LSAQPMGSLQQLQQQQQLQQQQQLQQQ----------QQQQLQQQQQL--- 3926
Query: 434 IRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIE 493
Q L Q Q + QQQ QQ ++Q+Q QQQ + + +
Sbjct: 3927 ----------------QQQQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQQQQQQQFQQQQ 3970
Query: 494 QLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRS----DSSACVDDTLGQVGAVKVKE 549
Q +Q G L ++ L Q Q+ A G + S + TL G +
Sbjct: 3971 QQQQMGL-LNQSRTLLSPQQQQQQQVALGPGMPAKPLQHFSSPGALGPTLLLTGKEQNTV 4029
Query: 550 EPVDSD-------------------------EDAQIQEMESGEQAAFMQQPFLEPTHT-- 582
+P S E +++ SG+ + QP +P +
Sbjct: 4030 DPAVSSEATEGPSTHQGGPLAIGTTPESMATEPGEVKPSLSGDSQLLLVQPQPQPQPSSL 4089
Query: 583 ------RALSVRQAPLAAVGMDGLEKHRLVSRTHSSPAASV---LPHPAMDRPLQPGSAT 633
R +Q ++ + G H + SS A+SV L P++ QPGS T
Sbjct: 4090 QLQPPLRLPGQQQQQVSLLHTAGGGSHGQLGSGSSSEASSVPHLLAQPSVSLGDQPGSMT 4149
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 52.0 bits (123), Expect = 3e-06
Identities = 104/548 (18%), Positives = 217/548 (39%), Gaps = 68/548 (12%)
Query: 43 EKQLQQELLLIQQQQQIQKQL--LIAEFQKQHENLTRQHQAQLQ-------EHIKELLAI 93
+K L +++ IQ++ + Q+ + ++ Q+E L Q ++ +H ++ +++
Sbjct: 1414 QKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSV 1473
Query: 94 KQQQELLE-------KEQKLEQQRQ-------EQEVERHRREQQLPPLRGK-DRGRERAV 138
++ QEL E K + LE Q + E+E E ++Q L+ + R R+
Sbjct: 1474 QEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQ 1533
Query: 139 ASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPS 198
T +++L++ + K + V+ K+ + A L + + L +
Sbjct: 1534 DRTTQEEQLRQQITEKEEKT------RKAIVAAKSKIAHLAGVKDQLTKENEELKQRN-- 1585
Query: 199 YKYTLPGAQDA-KDDFPLRKTASEPNLKVR-SRLKQKVAERRSSPLLRRKDGNVVTSFKK 256
GA D KD+ +R TA + + R SRL++++ E + L +R + ++
Sbjct: 1586 ------GALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVP 1639
Query: 257 RMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSM 316
+ +S G +S ++ PT ++ P A M +
Sbjct: 1640 EQQRQITLKTTPASGERGIASTSDPPTANIKPTPVVSTPSKVTAAAMAGNKST----PRA 1695
Query: 317 NLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQYGGSIPASS 376
++ + T ++ N T A + + ++ ++ +++ + VP+ G GS+ ++S
Sbjct: 1696 SIRPMVTPATVTNPTTTPTAT---VMPTTQVESQEAMQSEGPVEHVPVFGSTSGSVRSTS 1752
Query: 377 SHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRG 436
P+V ++ Q +L +Q Q V HPQ A +E S +
Sbjct: 1753 --PNV----------QPSISQPILTVQQQTQATAFVQPTQQSHPQIEPANQELSSNIVEV 1800
Query: 437 THKLPRHRPLNRT----QSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSI 492
P RP T + P S+L + +++ +E Q + L K +
Sbjct: 1801 VQSSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEASDQVSDDT-VEMPLPKKL 1859
Query: 493 EQLKQPGSHLE-EAEEELQGD---QAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVK 548
+ + G+ E AEE G+ Q +D S G ++D+ ++++
Sbjct: 1860 KSVTPVGTEEEVMAEESTDGEVETQVYNQDSQDSIGEGVTQGDYTPMEDSEETSQSLQID 1919
Query: 549 EEPVDSDE 556
P+ SD+
Sbjct: 1920 LGPLQSDQ 1927
Score = 31.2 bits (69), Expect = 5.4
Identities = 25/113 (22%), Positives = 57/113 (50%), Gaps = 6/113 (5%)
Query: 41 VREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKEL----LAIKQQ 96
V + +Q + L++++ Q + L AE +K +T + AQ +E +K+ + ++
Sbjct: 1219 VESLRYRQRVELLERELQELQDSLNAEREKVQ--VTAKTMAQHEELMKKTETMNVVMETN 1276
Query: 97 QELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149
+ L E++++LEQ Q+ + + + E + PL+ + + ++KL E
Sbjct: 1277 KMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLE 1329
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 52.0 bits (123), Expect = 3e-06
Identities = 62/246 (25%), Positives = 107/246 (43%), Gaps = 29/246 (11%)
Query: 53 IQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQ-RQ 111
+++QQ +Q+Q L ++ E RQ A+ Q+ I++ K+Q+ LE++Q+ E++ R+
Sbjct: 370 LRRQQLLQEQQL-----REQEEYKRQLLAERQKRIEQQ---KEQRRRLEEQQRREREARR 421
Query: 112 EQEVERHRREQ-------QLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNG 164
+QE E+ RREQ +L R ++ R RA ++ QE++ + +
Sbjct: 422 QQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEV 481
Query: 165 KNHSVSRHPKLW---YTAAHHTSLDQSSPPLSGTS-PSYKYTLPGAQ----DAKDDFPLR 216
+ + + + H Q PP S PS+ P A D + P+R
Sbjct: 482 LQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVPVR 541
Query: 217 KTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKR-MFEVTESSVSSSSPGSGP 275
T+ P L R Q ++ S R N +S + R ++E E V GS
Sbjct: 542 TTSRSPVLSRRDSPLQGSGQQNSQAGQR----NSTSSIEPRLLWERVEKLVPRPGSGSSS 597
Query: 276 SSPNNG 281
S N+G
Sbjct: 598 GSSNSG 603
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.369
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,427,342
Number of Sequences: 37866
Number of extensions: 2248208
Number of successful extensions: 20215
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 243
Number of HSP's successfully gapped in prelim test: 634
Number of HSP's that attempted gapping in prelim test: 10627
Number of HSP's gapped (non-prelim): 5408
length of query: 1066
length of database: 18,247,518
effective HSP length: 113
effective length of query: 953
effective length of database: 13,968,660
effective search space: 13312132980
effective search space used: 13312132980
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.