BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens] (1066 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens] 2117 0.0 gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens] 2112 0.0 gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens] 1999 0.0 gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens] 1708 0.0 gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens] 1165 0.0 gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens] 1165 0.0 gi|153085395 histone deacetylase 4 [Homo sapiens] 1134 0.0 gi|7662280 histone deacetylase 9 isoform 3 [Homo sapiens] 1126 0.0 gi|169234807 histone deacetylase 7 isoform a [Homo sapiens] 674 0.0 gi|148539870 histone deacetylase 7 isoform d [Homo sapiens] 653 0.0 gi|13128864 histone deacetylase 6 [Homo sapiens] 282 1e-75 gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens] 236 1e-61 gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens] 202 1e-51 gi|116284376 histone deacetylase 2 [Homo sapiens] 111 3e-24 gi|13128860 histone deacetylase 1 [Homo sapiens] 110 7e-24 gi|8923769 histone deacetylase 8 [Homo sapiens] 107 5e-23 gi|13128862 histone deacetylase 3 [Homo sapiens] 90 1e-17 gi|217272877 histone deacetylase 11 isoform 1 [Homo sapiens] 67 7e-11 gi|209862883 histone deacetylase 11 isoform 2 [Homo sapiens] 67 7e-11 gi|221139761 zinc finger protein 853 [Homo sapiens] 59 2e-08 gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 56 2e-07 gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 56 2e-07 gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 56 2e-07 gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens] 56 2e-07 gi|17017963 forkhead box P2 isoform I [Homo sapiens] 55 4e-07 gi|148746195 trichohyalin [Homo sapiens] 54 8e-07 gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 54 8e-07 gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 52 3e-06 gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 52 3e-06 gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 52 3e-06 >gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens] Length = 1066 Score = 2117 bits (5486), Expect = 0.0 Identities = 1066/1066 (100%), Positives = 1066/1066 (100%) Query: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ Sbjct: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60 Query: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR 120 KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR Sbjct: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR 120 Query: 121 EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA 180 EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA Sbjct: 121 EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA 180 Query: 181 HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS 240 HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS Sbjct: 181 HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS 240 Query: 241 PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA 300 PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA Sbjct: 241 PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA 300 Query: 301 EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ 360 EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ Sbjct: 301 EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ 360 Query: 361 GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP 420 GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP Sbjct: 361 GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP 420 Query: 421 QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ 480 QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ Sbjct: 421 QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ 480 Query: 481 QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG 540 QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG Sbjct: 481 QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG 540 Query: 541 QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGL 600 QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGL Sbjct: 541 QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGL 600 Query: 601 EKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGR 660 EKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGR Sbjct: 601 EKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGR 660 Query: 661 IQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGD 720 IQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGD Sbjct: 661 IQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGD 720 Query: 721 DSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPP 780 DSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPP Sbjct: 721 DSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPP 780 Query: 781 GHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI 840 GHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI Sbjct: 781 GHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI 840 Query: 841 SLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAK 900 SLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAK Sbjct: 841 SLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAK 900 Query: 901 EFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTA 960 EFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTA Sbjct: 901 EFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTA 960 Query: 961 ICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVPRGC 1020 ICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVPRGC Sbjct: 961 ICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVPRGC 1020 Query: 1021 ALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL 1066 ALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL Sbjct: 1021 ALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL 1066 >gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens] Length = 1069 Score = 2112 bits (5472), Expect = 0.0 Identities = 1066/1069 (99%), Positives = 1066/1069 (99%), Gaps = 3/1069 (0%) Query: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ Sbjct: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60 Query: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIK---ELLAIKQQQELLEKEQKLEQQRQEQEVER 117 KQLLIAEFQKQHENLTRQHQAQLQEHIK ELLAIKQQQELLEKEQKLEQQRQEQEVER Sbjct: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVER 120 Query: 118 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 177 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY Sbjct: 121 HRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWY 180 Query: 178 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 237 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER Sbjct: 181 TAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAER 240 Query: 238 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 297 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT Sbjct: 241 RSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPT 300 Query: 298 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 357 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT Sbjct: 301 PHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQT 360 Query: 358 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 417 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP Sbjct: 361 LRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVP 420 Query: 418 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 477 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ Sbjct: 421 LHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQ 480 Query: 478 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 537 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD Sbjct: 481 YQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDD 540 Query: 538 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM 597 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM Sbjct: 541 TLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGM 600 Query: 598 DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH 657 DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH Sbjct: 601 DGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEH 660 Query: 658 AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL 717 AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL Sbjct: 661 AGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRIL 720 Query: 718 LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV 777 LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV Sbjct: 721 LGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVV 780 Query: 778 RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI 837 RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI Sbjct: 781 RPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSI 840 Query: 838 LYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKP 897 LYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKP Sbjct: 841 LYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKP 900 Query: 898 VAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHD 957 VAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHD Sbjct: 901 VAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHD 960 Query: 958 LTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVP 1017 LTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVP Sbjct: 961 LTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVP 1020 Query: 1018 RGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL 1066 RGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL Sbjct: 1021 RGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL 1069 >gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens] Length = 1011 Score = 1999 bits (5179), Expect = 0.0 Identities = 1005/1005 (100%), Positives = 1005/1005 (100%) Query: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ Sbjct: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60 Query: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR 120 KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR Sbjct: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR 120 Query: 121 EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA 180 EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA Sbjct: 121 EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA 180 Query: 181 HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS 240 HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS Sbjct: 181 HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS 240 Query: 241 PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA 300 PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA Sbjct: 241 PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA 300 Query: 301 EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ 360 EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ Sbjct: 301 EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ 360 Query: 361 GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP 420 GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP Sbjct: 361 GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP 420 Query: 421 QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ 480 QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ Sbjct: 421 QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ 480 Query: 481 QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG 540 QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG Sbjct: 481 QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG 540 Query: 541 QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGL 600 QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGL Sbjct: 541 QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGL 600 Query: 601 EKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGR 660 EKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGR Sbjct: 601 EKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGR 660 Query: 661 IQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGD 720 IQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGD Sbjct: 661 IQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGD 720 Query: 721 DSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPP 780 DSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPP Sbjct: 721 DSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPP 780 Query: 781 GHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI 840 GHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI Sbjct: 781 GHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI 840 Query: 841 SLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAK 900 SLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAK Sbjct: 841 SLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAK 900 Query: 901 EFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTA 960 EFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTA Sbjct: 901 EFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTA 960 Query: 961 ICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQS 1005 ICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQS Sbjct: 961 ICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQS 1005 >gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens] Length = 879 Score = 1708 bits (4423), Expect = 0.0 Identities = 860/860 (100%), Positives = 860/860 (100%) Query: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ Sbjct: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60 Query: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR 120 KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR Sbjct: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR 120 Query: 121 EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA 180 EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA Sbjct: 121 EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA 180 Query: 181 HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS 240 HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS Sbjct: 181 HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS 240 Query: 241 PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA 300 PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA Sbjct: 241 PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA 300 Query: 301 EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ 360 EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ Sbjct: 301 EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ 360 Query: 361 GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP 420 GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP Sbjct: 361 GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP 420 Query: 421 QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ 480 QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ Sbjct: 421 QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ 480 Query: 481 QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG 540 QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG Sbjct: 481 QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG 540 Query: 541 QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGL 600 QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGL Sbjct: 541 QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGL 600 Query: 601 EKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGR 660 EKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGR Sbjct: 601 EKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGR 660 Query: 661 IQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGD 720 IQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGD Sbjct: 661 IQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGD 720 Query: 721 DSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPP 780 DSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPP Sbjct: 721 DSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPP 780 Query: 781 GHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI 840 GHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI Sbjct: 781 GHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI 840 Query: 841 SLHRYDEGNFFPGSGAPNEV 860 SLHRYDEGNFFPGSGAPNEV Sbjct: 841 SLHRYDEGNFFPGSGAPNEV 860 >gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens] Length = 1123 Score = 1165 bits (3013), Expect = 0.0 Identities = 651/1120 (58%), Positives = 799/1120 (71%), Gaps = 76/1120 (6%) Query: 1 MHSMISSVDVKSEVPVGLEPI---------SPLDLRTDLRMMMPVVDPVVREKQLQQELL 51 +HS+ +V+VK +P + SP++LR L + VDP +RE+QLQQELL Sbjct: 26 LHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVELRGAL---VGSVDPTLREQQLQQELL 82 Query: 52 LIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIK---ELLAIKQQQELL--EKEQKL 106 ++QQQQ+QKQLL AEFQKQH++LTRQH+ QLQ+H+K E+LA KQQQE+L +++Q+L Sbjct: 83 ALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQEL 142 Query: 107 EQQRQ-----EQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTP 161 EQQRQ ++E+E+ R EQQL LR K++ +E A+ASTEVK +LQEFLLSKS K+ Sbjct: 143 EQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQEFLLSKS--KEPT 200 Query: 162 TNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSG---TSPSYKYTLPGAQDAKDDFPLRKT 218 G NHS+ +HPK W AHH SLDQSSPP SG T PSYK LPG D++DDFPLRKT Sbjct: 201 PGGLNHSLPQHPKCW--GAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKT 258 Query: 219 ASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVT-----ESSVSSSSPGS 273 ASEPNLKVRSRLKQKVAERRSSPLLRRKDG V+++FKKR E+T SSV +S+PGS Sbjct: 259 ASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGS 318 Query: 274 GPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLG 333 GPSSPN+ + T +P P +M+ Q R L + S N SLYTSPSLPNI+LG Sbjct: 319 GPSSPNSSHSTIAENGFTGSVPNIP--TEMLPQHRALPLDSSPNQFSLYTSPSLPNISLG 376 Query: 334 LPAVP----SQLNASNSLKEKQKCETQ---TLRQGVPLPGQYGGSIPASSSHPHVTLEGK 386 L A S L AS L +Q+ E Q +LRQG L G++ + V LEG Sbjct: 377 LQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGD 436 Query: 387 PPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPL 446 H +LLQH+LL EQ RQQ L+A VPLH QSPL T ER++ +R KLPRHRPL Sbjct: 437 GSPHGHASLLQHVLLLEQARQQSTLIA--VPLHGQSPLVTGERVATSMRTVGKLPRHRPL 494 Query: 447 NRTQSAPLPQS--TLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEE 504 +RTQS+PLPQS L QLV+QQQHQQFLEKQKQ QQ+ + K+L+K+ E +QP +H EE Sbjct: 495 SRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQ--QQLQLGKILTKTGELPRQPTTHPEE 552 Query: 505 AEEELQ-------GDQAMQEDRAPSS-GNSTRSD--SSACVDDTLGQVGAVKVKEEPVDS 554 EEEL G+ A+ R S+ ST+ D DD + ++VK+E +S Sbjct: 553 TEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGES 612 Query: 555 --DEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTHSS 612 +E ++E +G + F L+P L V QAPL+ + H+ + RT SS Sbjct: 613 GAEEGPDLEEPGAGYKKLFSDAQPLQP-----LQVYQAPLSLATVP----HQALGRTQSS 663 Query: 613 PAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETG 672 PAA D+P++ TG+ YD MLKHQC+CGN+ HPEHAGRIQSIWSRLQETG Sbjct: 664 PAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETG 723 Query: 673 LLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCG 732 LL+KCERI+GRKA+L+EIQ VHSE+H+LLYGT+PL+ QKLD + LLG SQK ++ LPCG Sbjct: 724 LLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCG 783 Query: 733 GLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGF 792 G+GVDSDT+WNE+HSS A RMAVGC++ELA KVA+GELKNGFA++RPPGHHAEESTAMGF Sbjct: 784 GIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGF 843 Query: 793 CFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP 852 CFFNSVAITAK L+ +LN+ K+LIVD D+HHGNGTQQAFY DPS+LYISLHRYD GNFFP Sbjct: 844 CFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP 903 Query: 853 GSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAG 912 GSGAP EVG G G GYN+N+AWTGG+DPP+GDVEYL AFRT+V P+A EF PD+VLVSAG Sbjct: 904 GSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAG 963 Query: 913 FDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNAL 972 FDA+EGH PLGGY VTA+CFGHLT+QLMTLA GRVVLALEGGHDLTAICDASEACV+AL Sbjct: 964 FDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSAL 1023 Query: 973 LGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVPRGCALAGAQL--QEE 1030 L EL+PL E +L Q PN+NAV +L+K+IEIQSK+W V+ A G +L AQ EE Sbjct: 1024 LSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEE 1083 Query: 1031 TETVSALASLTVDVEQPFA----QEDSRTAGEPMEEEPAL 1066 ETVSA+A L+V EQ A + R A EPME+EPAL Sbjct: 1084 AETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL 1123 >gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens] Length = 1122 Score = 1165 bits (3013), Expect = 0.0 Identities = 651/1120 (58%), Positives = 799/1120 (71%), Gaps = 76/1120 (6%) Query: 1 MHSMISSVDVKSEVPVGLEPI---------SPLDLRTDLRMMMPVVDPVVREKQLQQELL 51 +HS+ +V+VK +P + SP++LR L + VDP +RE+QLQQELL Sbjct: 25 LHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVELRGAL---VGSVDPTLREQQLQQELL 81 Query: 52 LIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIK---ELLAIKQQQELL--EKEQKL 106 ++QQQQ+QKQLL AEFQKQH++LTRQH+ QLQ+H+K E+LA KQQQE+L +++Q+L Sbjct: 82 ALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQEL 141 Query: 107 EQQRQ-----EQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTP 161 EQQRQ ++E+E+ R EQQL LR K++ +E A+ASTEVK +LQEFLLSKS K+ Sbjct: 142 EQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQEFLLSKS--KEPT 199 Query: 162 TNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSG---TSPSYKYTLPGAQDAKDDFPLRKT 218 G NHS+ +HPK W AHH SLDQSSPP SG T PSYK LPG D++DDFPLRKT Sbjct: 200 PGGLNHSLPQHPKCW--GAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKT 257 Query: 219 ASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVT-----ESSVSSSSPGS 273 ASEPNLKVRSRLKQKVAERRSSPLLRRKDG V+++FKKR E+T SSV +S+PGS Sbjct: 258 ASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGS 317 Query: 274 GPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLG 333 GPSSPN+ + T +P P +M+ Q R L + S N SLYTSPSLPNI+LG Sbjct: 318 GPSSPNSSHSTIAENGFTGSVPNIP--TEMLPQHRALPLDSSPNQFSLYTSPSLPNISLG 375 Query: 334 LPAVP----SQLNASNSLKEKQKCETQ---TLRQGVPLPGQYGGSIPASSSHPHVTLEGK 386 L A S L AS L +Q+ E Q +LRQG L G++ + V LEG Sbjct: 376 LQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGD 435 Query: 387 PPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPL 446 H +LLQH+LL EQ RQQ L+A VPLH QSPL T ER++ +R KLPRHRPL Sbjct: 436 GSPHGHASLLQHVLLLEQARQQSTLIA--VPLHGQSPLVTGERVATSMRTVGKLPRHRPL 493 Query: 447 NRTQSAPLPQS--TLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEE 504 +RTQS+PLPQS L QLV+QQQHQQFLEKQKQ QQ+ + K+L+K+ E +QP +H EE Sbjct: 494 SRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQ--QQLQLGKILTKTGELPRQPTTHPEE 551 Query: 505 AEEELQ-------GDQAMQEDRAPSS-GNSTRSD--SSACVDDTLGQVGAVKVKEEPVDS 554 EEEL G+ A+ R S+ ST+ D DD + ++VK+E +S Sbjct: 552 TEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGES 611 Query: 555 --DEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTHSS 612 +E ++E +G + F L+P L V QAPL+ + H+ + RT SS Sbjct: 612 GAEEGPDLEEPGAGYKKLFSDAQPLQP-----LQVYQAPLSLATVP----HQALGRTQSS 662 Query: 613 PAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETG 672 PAA D+P++ TG+ YD MLKHQC+CGN+ HPEHAGRIQSIWSRLQETG Sbjct: 663 PAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETG 722 Query: 673 LLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCG 732 LL+KCERI+GRKA+L+EIQ VHSE+H+LLYGT+PL+ QKLD + LLG SQK ++ LPCG Sbjct: 723 LLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCG 782 Query: 733 GLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGF 792 G+GVDSDT+WNE+HSS A RMAVGC++ELA KVA+GELKNGFA++RPPGHHAEESTAMGF Sbjct: 783 GIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGF 842 Query: 793 CFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP 852 CFFNSVAITAK L+ +LN+ K+LIVD D+HHGNGTQQAFY DPS+LYISLHRYD GNFFP Sbjct: 843 CFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP 902 Query: 853 GSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAG 912 GSGAP EVG G G GYN+N+AWTGG+DPP+GDVEYL AFRT+V P+A EF PD+VLVSAG Sbjct: 903 GSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAG 962 Query: 913 FDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNAL 972 FDA+EGH PLGGY VTA+CFGHLT+QLMTLA GRVVLALEGGHDLTAICDASEACV+AL Sbjct: 963 FDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSAL 1022 Query: 973 LGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVPRGCALAGAQL--QEE 1030 L EL+PL E +L Q PN+NAV +L+K+IEIQSK+W V+ A G +L AQ EE Sbjct: 1023 LSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEE 1082 Query: 1031 TETVSALASLTVDVEQPFA----QEDSRTAGEPMEEEPAL 1066 ETVSA+A L+V EQ A + R A EPME+EPAL Sbjct: 1083 AETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL 1122 >gi|153085395 histone deacetylase 4 [Homo sapiens] Length = 1084 Score = 1134 bits (2934), Expect = 0.0 Identities = 627/1093 (57%), Positives = 779/1093 (71%), Gaps = 60/1093 (5%) Query: 1 MHSMISSVDVKSEVPVGLEPIS-PLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQI 59 ++ M S+VDV + +P+ + P + P+DLR D + +PV +P +RE+QLQQELL ++Q+QQI Sbjct: 25 VNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQI 84 Query: 60 QKQLLIAEFQKQHENLTRQHQAQLQEHIK---ELLAIKQQQELLEKEQKLEQQRQEQEVE 116 Q+Q+LIAEFQ+QHE L+RQH+AQL EHIK E+LA+K QQELLE ++KLE+ RQEQE+E Sbjct: 85 QRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELE 144 Query: 117 RHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLW 176 + REQ+L L+ K++G+E AVASTEVK KLQEF+L+K K NH +S P+ W Sbjct: 145 KQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVLNKK--KALAHRNLNHCISSDPRYW 202 Query: 177 YTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAE 236 Y H+SLDQSSPP SG S SY + + G DAKDDFPLRKTASEPNLK+RSRLKQKVAE Sbjct: 203 YGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAE 262 Query: 237 RRSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPP 296 RRSSPLLRRKDG VVT+ KKR +VT+S+ SS+ PGSGPSSPNN EN + P Sbjct: 263 RRSSPLLRRKDGPVVTALKKRPLDVTDSACSSA-PGSGPSSPNNSSGSVSAENGIAPAVP 321 Query: 297 TPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQ 356 + AE ++ R++ E S L LYTSPSLPNITLGLPA + ++ ++ Sbjct: 322 SIPAETSLAH-RLVAREGSAAPLPLYTSPSLPNITLGLPATGPSAGTAGQ-QDAERLTLP 379 Query: 357 TLRQGVPL-PGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAG- 414 L+Q + L PG + P S+ P LE + ++H LLQH++L EQ Q LV G Sbjct: 380 ALQQRLSLFPGTH--LTPYLSTSP---LE-RDGGAAHSPLLQHMVLLEQPPAQAPLVTGL 433 Query: 415 -GVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQST--LAQLVIQQQHQQF 471 +PLH QS L +R+SP I HKL +HRPL RTQSAPLPQ+ L LVIQQQHQQF Sbjct: 434 GALPLHAQS-LVGADRVSPSI---HKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQF 489 Query: 472 LEKQKQY--QQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQE----DRAPSSGN 525 LEK KQ QQQ+ MNK++ K E +QP SH EE EEEL+ QA+ + DR P Sbjct: 490 LEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPYLDRLPGQ-- 547 Query: 526 STRSDSSACVDDTLGQVGAVKVKEEPVDSDEDAQI--------QEMESGEQAAFMQQPFL 577 + Q G V+VK+EP++SDE+ Q S ++ F QQ L Sbjct: 548 ----------KEAHAQAG-VQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALL 596 Query: 578 -EPTHTRALSVRQAPLAAVGMD-GLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGI 635 E L QA + A G+ HR +SR SSPA++ P + P +P TG+ Sbjct: 597 LEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGL 656 Query: 636 AYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHS 695 YD LMLKHQC CG+S++HPEHAGRIQSIWSRLQETGL KCE I+GRKA+LEE+Q VHS Sbjct: 657 VYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHS 716 Query: 696 EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAV 755 E H+LLYGTNPL+ QKLD + LLG + F LPCGG+GVDSDTIWNE+HS+GAAR+AV Sbjct: 717 EAHTLLYGTNPLNRQKLDSKKLLGSLASVFVR-LPCGGVGVDSDTIWNEVHSAGAARLAV 775 Query: 756 GCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKIL 815 GCV+EL KVA+GELKNGFAVVRPPGHHAEEST MGFC+FNSVA+ AK L+ +L++SKIL Sbjct: 776 GCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKIL 835 Query: 816 IVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWT 875 IVD DVHHGNGTQQAFY+DPS+LY+SLHRYD+GNFFPGSGAP+EVGTG G G+N+N+A+T Sbjct: 836 IVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFT 895 Query: 876 GGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGH 935 GGLDPPMGD EYL AFRT+V P+A EF PD+VLVS+GFDA+EGH PLGGY ++A+CFG+ Sbjct: 896 GGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGY 955 Query: 936 LTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVI 995 LTKQLM LA GR+VLALEGGHDLTAICDASEACV+ALLGNEL+PL E +L Q PN NAV Sbjct: 956 LTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVR 1015 Query: 996 SLQKIIEIQSKYWKSVRMVAVPRGCALAGAQL--QEETETVSALASLTVDVEQPFAQEDS 1053 S++K++EI SKYW+ ++ G +L AQ EE ETV+A+ASL+V V+ + Sbjct: 1016 SMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVK----PAEK 1071 Query: 1054 RTAGEPMEEEPAL 1066 R EPMEEEP L Sbjct: 1072 RPDEEPMEEEPPL 1084 >gi|7662280 histone deacetylase 9 isoform 3 [Homo sapiens] Length = 590 Score = 1126 bits (2913), Expect = 0.0 Identities = 574/574 (100%), Positives = 574/574 (100%) Query: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ Sbjct: 1 MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ 60 Query: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR 120 KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR Sbjct: 61 KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR 120 Query: 121 EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA 180 EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA Sbjct: 121 EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA 180 Query: 181 HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS 240 HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS Sbjct: 181 HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS 240 Query: 241 PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA 300 PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA Sbjct: 241 PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA 300 Query: 301 EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ 360 EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ Sbjct: 301 EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ 360 Query: 361 GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP 420 GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP Sbjct: 361 GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP 420 Query: 421 QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ 480 QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ Sbjct: 421 QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ 480 Query: 481 QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG 540 QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG Sbjct: 481 QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG 540 Query: 541 QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQ 574 QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQ Sbjct: 541 QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQ 574 >gi|169234807 histone deacetylase 7 isoform a [Homo sapiens] Length = 991 Score = 674 bits (1739), Expect = 0.0 Identities = 454/1023 (44%), Positives = 572/1023 (55%), Gaps = 126/1023 (12%) Query: 75 LTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGR 134 L Q +L H+ LA QQQ +E +L E++ +EQ+L L KD+ + Sbjct: 59 LALQRPQRLHHHL--FLAGLQQQRSVEP-MRLSMDTPMPELQVGPQEQELRQLLHKDKSK 115 Query: 135 ERAVASTEVKQKLQEFLLSKSAT---KDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPP 191 AVAS+ VKQKL E +L K + N L A + L PP Sbjct: 116 RSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPP 175 Query: 192 LSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVV 251 + +LP D + FPLRKT SEPNLK+R + K+ + ERR +PLLR++ + Sbjct: 176 VP--------SLPS--DPPEHFPLRKTVSEPNLKLRYKPKKSL-ERRKNPLLRKE--SAP 222 Query: 252 TSFKKRMFEVT--ESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPH-AEQMVSQQR 308 S ++R E S SSS+P SG SSPN+ G P P + + QR Sbjct: 223 PSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHG-----------PNPILGSEALLGQR 271 Query: 309 ILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVP----- 363 + + E S+ +L T LP ITLGLPA P++ ++ L G P Sbjct: 272 LRLQETSVAPFALPTVSLLPAITLGLPA-PARADSDRRTHPTLGPRGPIL--GSPHTPLF 328 Query: 364 ----LPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLH 419 L + GG++P S P + L+ P+ SH LL L G +P H Sbjct: 329 LPHGLEPEAGGTLP-SRLQPILLLD---PSGSHAPLLTVPGL------------GPLPFH 372 Query: 420 PQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQ 479 L T ER+S H PL+RT+S PLP S A Q LE+ K + Sbjct: 373 FAQSLMTTERLSGS-------GLHWPLSRTRSEPLPPSATAPPPPGPM-QPRLEQLKTHV 424 Query: 480 QQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTL 539 Q ++ +S + ++P + E+L+ D VDD L Sbjct: 425 Q------VIKRSAKPSEKPRLRQIPSAEDLETDGG---------------GPGQVVDDGL 463 Query: 540 GQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDG 599 +E E ++ Q +Q L R S L + G Sbjct: 464 EH------RELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRG-STGDTVLLPLAQGG 516 Query: 600 LEKHRLVSRTHSSPAASV---LPHPAMDRPLQPGS---------ATGIAYDPLMLKHQCV 647 HR +SR SSPAA P PA + S TG+ YD +MLKHQC Sbjct: 517 ---HRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCS 573 Query: 648 CGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPL 707 CG+++ HPEHAGRIQSIWSRLQE GL ++CE ++GRKASLEE+Q VHSE H LLYGTNPL Sbjct: 574 CGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPL 633 Query: 708 DGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVAS 767 KLD L G +Q+ F LPCGG+GVD+DTIWNELHSS AAR A G V +LA KVAS Sbjct: 634 SRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVAS 693 Query: 768 GELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGT 827 ELKNGFAVVRPPGHHA+ STAMGFCFFNSVAI + L+ Q SKILIVD DVHHGNGT Sbjct: 694 RELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGT 753 Query: 828 QQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEY 887 QQ FY DPS+LYISLHR+D+GNFFPGSGA +EVG G GEG+N+N+AW GGLDPPMGD EY Sbjct: 754 QQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEY 813 Query: 888 LEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGR 947 L AFR +V P+A+EF PD+VLVSAGFDA EGH PLGGY V+AKCFG++T+QLM LA G Sbjct: 814 LAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGA 873 Query: 948 VVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKY 1007 VVLALEGGHDLTAICDASEACV ALLGN ++PL+E+ Q PN+NA+ SL+ +I + SKY Sbjct: 874 VVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKY 933 Query: 1008 WKSVRMVA------VPRGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPME 1061 W ++ +A VPR + GA +EE E V+ALASL+V + ED + E Sbjct: 934 WGCMQRLASCPDSWVPR---VPGAD-KEEVEAVTALASLSVGI----LAEDRPSEQLVEE 985 Query: 1062 EEP 1064 EEP Sbjct: 986 EEP 988 >gi|148539870 histone deacetylase 7 isoform d [Homo sapiens] Length = 954 Score = 653 bits (1684), Expect = 0.0 Identities = 444/1015 (43%), Positives = 553/1015 (54%), Gaps = 147/1015 (14%) Query: 75 LTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGR 134 L Q +L H+ LA QQQ +E +L E++ +EQ+L L KD+ + Sbjct: 59 LALQRPQRLHHHL--FLAGLQQQRSVEP-MRLSMDTPMPELQVGPQEQELRQLLHKDKSK 115 Query: 135 ERAVASTEVKQKLQEFLLSKSAT---KDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPP 191 AVAS+ VKQKL E +L K + N L A + L PP Sbjct: 116 RSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPP 175 Query: 192 LSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVV 251 + +LP D + FPLRKT SEPNLK+R + K+ + ERR +PLLR++ + Sbjct: 176 VP--------SLPS--DPPEHFPLRKTVSEPNLKLRYKPKKSL-ERRKNPLLRKE--SAP 222 Query: 252 TSFKKRMFEVT--ESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRI 309 S ++R E S SSS+P SG SSPN+ G P P R Sbjct: 223 PSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHG-----------PNPILGSEADSDR- 270 Query: 310 LIHEDSMNLLSLYTSPSLP--NITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQ 367 T P+L LG P P L L + Sbjct: 271 ------------RTHPTLGPRGPILGSPHTPLFLPHG-------------------LEPE 299 Query: 368 YGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATK 427 GG++P S P + L+ P+ SH LL L G +P H L T Sbjct: 300 AGGTLP-SRLQPILLLD---PSGSHAPLLTVPGL------------GPLPFHFAQSLMTT 343 Query: 428 ERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKL 487 ER+S H PL+RT+S PLP S A Q LE+ K + Q + Sbjct: 344 ERLSGS-------GLHWPLSRTRSEPLPPSATAPPPPGPM-QPRLEQLKTHVQ------V 389 Query: 488 LSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKV 547 + +S + ++P + E+L+ D VDD L Sbjct: 390 IKRSAKPSEKPRLRQIPSAEDLETDGG---------------GPGQVVDDGLEH------ 428 Query: 548 KEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVS 607 +E E ++ Q +Q L R S L + G HR +S Sbjct: 429 RELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRG-STGDTVLLPLAQGG---HRPLS 484 Query: 608 RTHSSPAASV---LPHPAMDRPLQPGS---------ATGIAYDPLMLKHQCVCGNSTTHP 655 R SSPAA P PA + S TG+ YD +MLKHQC CG+++ HP Sbjct: 485 RAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHP 544 Query: 656 EHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPR 715 EHAGRIQSIWSRLQE GL ++CE ++GRKASLEE+Q VHSE H LLYGTNPL KLD Sbjct: 545 EHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNG 604 Query: 716 ILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFA 775 L G +Q+ F LPCGG+GVD+DTIWNELHSS AAR A G V +LA KVAS ELKNGFA Sbjct: 605 KLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFA 664 Query: 776 VVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADP 835 VVRPPGHHA+ STAMGFCFFNSVAI + L+ Q SKILIVD DVHHGNGTQQ FY DP Sbjct: 665 VVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDP 724 Query: 836 SILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIV 895 S+LYISLHR+D+GNFFPGSGA +EVG G GEG+N+N+AW GGLDPPMGD EYL AFR +V Sbjct: 725 SVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVV 784 Query: 896 KPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGG 955 P+A+EF PD+VLVSAGFDA EGH PLGGY V+AKCFG++T+QLM LA G VVLALEGG Sbjct: 785 MPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGG 844 Query: 956 HDLTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVA 1015 HDLTAICDASEACV ALLGN ++PL+E+ Q PN+NA+ SL+ +I + SKYW ++ +A Sbjct: 845 HDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLA 904 Query: 1016 ------VPRGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEP 1064 VPR + GA +EE E V+ALASL+V + ED + EEEP Sbjct: 905 SCPDSWVPR---VPGAD-KEEVEAVTALASLSVGI----LAEDRPSEQLVEEEEP 951 >gi|13128864 histone deacetylase 6 [Homo sapiens] Length = 1215 Score = 282 bits (722), Expect = 1e-75 Identities = 169/408 (41%), Positives = 234/408 (57%), Gaps = 39/408 (9%) Query: 613 PAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETG 672 P +L P + S TG+ YD M+ H C +S HPE RI I RL+E G Sbjct: 467 PVLPILTWPVLQ------SRTGLVYDQNMMNH-CNLWDSH-HPEVPQRILRIMCRLEELG 518 Query: 673 LLNKCERIQGRKASLEEIQLVHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPC 731 L +C + R A+ E+ HS E+ L T + ++L +S F S C Sbjct: 519 LAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHR------ESSNFDSIYIC 572 Query: 732 GGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMG 791 + A++A G L V SGE+ NG AVVRPPGHHAE+ A G Sbjct: 573 PS-------------TFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACG 619 Query: 792 FCFFNSVAITAKYLRD-QLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNF 850 FCFFNSVA+ A++ + + +ILIVD DVHHGNGTQ F DPS+LY+SLHRYD G F Sbjct: 620 FCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTF 679 Query: 851 FP--GSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVL 908 FP GA +++G G G+ +N+AW G P MGD +YL A+ +V P+A EF+P++VL Sbjct: 680 FPMGDEGASSQIGRAAGTGFTVNVAWNG---PRMGDADYLAAWHRLVLPIAYEFNPELVL 736 Query: 909 VSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEAC 968 VSAGFDA G PLGG +V+ + + HLT LM LA GR++L LEGG++LT+I ++ AC Sbjct: 737 VSAGFDAARG--DPLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAAC 794 Query: 969 VNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAV 1016 +LLG +P L + P A+ S+ + I++ +YW+S+R++ V Sbjct: 795 TRSLLG---DPPPLLTLPRPPLSGALASITETIQVHRRYWRSLRVMKV 839 Score = 236 bits (603), Expect = 7e-62 Identities = 143/382 (37%), Positives = 212/382 (55%), Gaps = 32/382 (8%) Query: 631 SATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEI 690 + TG+ D + + C+ +S PE R+ +I +L + GLL++C Q R A EE+ Sbjct: 84 AGTGLVLDEQLNEFHCLWDDS--FPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEEL 141 Query: 691 QLVHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSG 749 LVHS E+ L+ T ++ +L R+L D+++ +S Sbjct: 142 MLVHSLEYIDLMETTQYMNEGEL--RVLADT-----------------YDSVYLHPNSYS 182 Query: 750 AARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQL 809 A +A G V+ L V E++NG A++RPPGHHA+ S G+C FN VA+ A+Y + + Sbjct: 183 CACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKH 242 Query: 810 NISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPN--EVGTGLGEG 867 I ++LIVD DVHHG GTQ F DPS+LY S+HRY++G F+P A N G G G+G Sbjct: 243 RIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQG 302 Query: 868 YNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYK 927 Y IN+ W M D +Y+ AF ++ PVA EF P +VLV+AGFDAL+G P G Sbjct: 303 YTINVPWN---QVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQG--DPKGEMA 357 Query: 928 VTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQ 987 T F LT LM LA G+++L+LEGG++L A+ + A ++ LLG+ P+ E Sbjct: 358 ATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPC-PMLES--PG 414 Query: 988 SPNMNAVISLQKIIEIQSKYWK 1009 +P +A S+ +E +W+ Sbjct: 415 APCRSAQASVSCALEALEPFWE 436 >gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens] Length = 669 Score = 236 bits (601), Expect = 1e-61 Identities = 143/391 (36%), Positives = 213/391 (54%), Gaps = 33/391 (8%) Query: 633 TGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQL 692 T + Y M + + + E R+ + RL++ GL +C R+ R+AS EE+ L Sbjct: 3 TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62 Query: 693 VHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAA 751 VHS E+ SL+ T L ++L L D I+ + A Sbjct: 63 VHSPEYVSLVRETQVLGKEELQ-------------------ALSGQFDAIYFHPSTFHCA 103 Query: 752 RMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNI 811 R+A G ++L V +G ++NG A+VRPPGHH + + A GFC FN+VAI A + + + + Sbjct: 104 RLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGL 163 Query: 812 SKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP--GSGAPNEVGTGLGEGYN 869 +IL+VD DVHHG G Q F DPS+LY S HRY+ G F+P + VG G G G+ Sbjct: 164 HRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFT 223 Query: 870 INIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVT 929 +N+ W MG+ +Y+ AF ++ P+A EFDP++VLVSAGFD+ G P G + T Sbjct: 224 VNLPWN---QVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIG--DPEGQMQAT 278 Query: 930 AKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSP 989 +CF HLT+ L LA GRV LEGG+ L ++ ++ V LLG+ PL+ + +P Sbjct: 279 PECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPM---AP 335 Query: 990 NMNAVISLQKIIEIQSKYWKSVR---MVAVP 1017 +A+ S+Q Q+ +WKS++ + AVP Sbjct: 336 CQSALESIQSARAAQAPHWKSLQQQDVTAVP 366 >gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens] Length = 649 Score = 202 bits (514), Expect = 1e-51 Identities = 130/391 (33%), Positives = 197/391 (50%), Gaps = 53/391 (13%) Query: 633 TGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQL 692 T + Y M + + + E R+ + RL++ GL +C R+ R+AS EE+ L Sbjct: 3 TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62 Query: 693 VHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAA 751 VHS E+ SL+ T L ++L L D I+ + A Sbjct: 63 VHSPEYVSLVRETQVLGKEELQ-------------------ALSGQFDAIYFHPSTFHCA 103 Query: 752 RMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNI 811 R+A G ++L V +G ++NG A+VRPPGHH + + A GFC FN+VAI A + + + + Sbjct: 104 RLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGL 163 Query: 812 SKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP--GSGAPNEVGTGLGEGYN 869 +IL+VD DVHHG G Q F DPS+LY S HRY+ G F+P + VG G G G+ Sbjct: 164 HRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFT 223 Query: 870 INIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVT 929 +N+ W MG+ +Y+ AF ++ P+A E G + T Sbjct: 224 VNLPWN---QVGMGNADYVAAFLHLLLPLAFE----------------------GQMQAT 258 Query: 930 AKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSP 989 +CF HLT+ L LA GRV LEGG+ L ++ ++ V LLG+ PL+ + +P Sbjct: 259 PECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPM---AP 315 Query: 990 NMNAVISLQKIIEIQSKYWKSVR---MVAVP 1017 +A+ S+Q Q+ +WKS++ + AVP Sbjct: 316 CQSALESIQSARAAQAPHWKSLQQQDVTAVP 346 >gi|116284376 histone deacetylase 2 [Homo sapiens] Length = 582 Score = 111 bits (278), Expect = 3e-24 Identities = 105/384 (27%), Positives = 168/384 (43%), Gaps = 61/384 (15%) Query: 654 HPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHH----SLLYGTNPLDG 709 HP RI+ + L GL K E + KA+ EE+ HS+ + + N + Sbjct: 123 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEY 182 Query: 710 QKLDPRILLGDDSQKF-----FSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASK 764 K R +G+D F F L GG V N + A A G Sbjct: 183 SKQMQRFNVGEDCPVFDGLFEFCQLSTGG-SVAGAVKLNRQQTDMAVNWAGGL------- 234 Query: 765 VASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHG 824 HHA++S A GFC+ N + + L ++L +D+D+HHG Sbjct: 235 -----------------HHAKKSEASGFCYVNDIVLAILELLKY--HQRVLYIDIDIHHG 275 Query: 825 NGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGD 884 +G ++AFY ++ +S H+Y G +FPG+G ++G G G+ Y +N G+D D Sbjct: 276 DGVEEAFYTTDRVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNFPMRDGID----D 329 Query: 885 VEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLA 944 Y + F+ I+ V + + P V++ G D+L G LG + +T K GH K + + Sbjct: 330 ESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDR--LGCFNLTVK--GH-AKCVEVVK 384 Query: 945 DGRVVLALEGGHDLT----AICDASEACV--NALLGNEL------EPLAEDI-LHQSP-N 990 + L + GG T A C E V + + NEL E D LH SP N Sbjct: 385 TFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSN 444 Query: 991 MNAVISLQKIIEIQSKYWKSVRMV 1014 M + + + +I+ + ++++RM+ Sbjct: 445 MTNQNTPEYMEKIKQRLFENLRML 468 >gi|13128860 histone deacetylase 1 [Homo sapiens] Length = 482 Score = 110 bits (275), Expect = 7e-24 Identities = 105/385 (27%), Positives = 170/385 (44%), Gaps = 63/385 (16%) Query: 654 HPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGT----NPLDG 709 HP RI+ + L GL K E + KA+ EE+ HS+ + + N + Sbjct: 28 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEY 87 Query: 710 QKLDPRILLGDDSQKF-----FSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASK 764 K R +G+D F F L GG +AS Sbjct: 88 SKQMQRFNVGEDCPVFDGLFEFCQLSTGG--------------------------SVASA 121 Query: 765 VASGELKNGFAVVRPPG-HHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHH 823 V + + AV G HHA++S A GFC+ N + + L ++L +D+D+HH Sbjct: 122 VKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQ--RVLYIDIDIHH 179 Query: 824 GNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMG 883 G+G ++AFY ++ +S H+Y G +FPG+G ++G G G+ Y +N G+D Sbjct: 180 GDGVEEAFYTTDRVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNYPLRDGID---- 233 Query: 884 DVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTL 943 D Y F+ ++ V + F P V++ G D+L G LG + +T K GH K + + Sbjct: 234 DESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDR--LGCFNLTIK--GH-AKCVEFV 288 Query: 944 ADGRVVLALEGGHDLT----AICDASEACV--NALLGNEL------EPLAEDI-LHQSP- 989 + + + GG T A C E V + + NEL E D LH SP Sbjct: 289 KSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPS 348 Query: 990 NMNAVISLQKIIEIQSKYWKSVRMV 1014 NM + + + +I+ + ++++RM+ Sbjct: 349 NMTNQNTNEYLEKIKQRLFENLRML 373 >gi|8923769 histone deacetylase 8 [Homo sapiens] Length = 377 Score = 107 bits (268), Expect = 5e-23 Identities = 93/362 (25%), Positives = 167/362 (46%), Gaps = 42/362 (11%) Query: 623 MDRPLQPGSATGIAYDPLML---KHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCER 679 M+ P +P + G + P+ + ++ +C + P+ A + S+ ++ L + Sbjct: 1 MEEPEEPADS-GQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSL---IEAYALHKQMRI 56 Query: 680 IQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVD-- 737 ++ + AS+EE+ H++ + Q L GDD GLG D Sbjct: 57 VKPKVASMEEMATFHTDAYL----------QHLQKVSQEGDDDHPDSIEY---GLGYDCP 103 Query: 738 -SDTIWNELHSSGAARM-AVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFF 795 ++ I++ + G A + A C+I+ KVA G+ HHA++ A GFC+ Sbjct: 104 ATEGIFDYAAAIGGATITAAQCLIDGMCKVAIN-WSGGW-------HHAKKDEASGFCYL 155 Query: 796 NSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSG 855 N + LR + +IL VDLD+HHG+G + AF ++ +SLH++ G FFPG+G Sbjct: 156 NDAVLGILRLRRKFE--RILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPG-FFPGTG 212 Query: 856 APNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDA 915 ++VG G G Y++N+ G+ D +Y + +++K V + F+P V++ G D Sbjct: 213 DVSDVGLGKGRYYSVNVPIQDGIQ----DEKYYQICESVLKEVYQAFNPKAVVLQLGADT 268 Query: 916 LEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGN 975 + G P+ + +T G K ++ ++L GG++L +LG Sbjct: 269 IAG--DPMCSFNMTPVGIGKCLKYILQWQLATLILG-GGGYNLANTARCWTYLTGVILGK 325 Query: 976 EL 977 L Sbjct: 326 TL 327 >gi|13128862 histone deacetylase 3 [Homo sapiens] Length = 428 Score = 89.7 bits (221), Expect = 1e-17 Identities = 47/136 (34%), Positives = 74/136 (54%), Gaps = 9/136 (6%) Query: 782 HHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYIS 841 HHA++ A GFC+ N + I L ++L +D+D+HHG+G Q+AFY ++ +S Sbjct: 134 HHAKKFEASGFCYVNDIVIGILELLKYH--PRVLYIDIDIHHGDGVQEAFYLTDRVMTVS 191 Query: 842 LHRYDEGN-FFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAK 900 H+Y GN FFPG+G EVG G Y +N+ G+D D Y F+ ++ V Sbjct: 192 FHKY--GNYFFPGTGDMYEVGAESGRYYCLNVPLRDGID----DQSYKHLFQPVINQVVD 245 Query: 901 EFDPDMVLVSAGFDAL 916 + P +++ G D+L Sbjct: 246 FYQPTCIVLQCGADSL 261 >gi|217272877 histone deacetylase 11 isoform 1 [Homo sapiens] Length = 347 Score = 67.4 bits (163), Expect = 7e-11 Identities = 75/317 (23%), Positives = 135/317 (42%), Gaps = 51/317 (16%) Query: 649 GNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHH--SLLYGTNP 706 G HP AG+ + + L+E LL+ ++ R+AS E++ +VH+ + L + Sbjct: 30 GLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAV 89 Query: 707 LDGQKLDPRILLGDD--SQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASK 764 ++ P I L + +K L R G I +A K Sbjct: 90 ATITEIPPVIFLPNFLVQRKVLRPL----------------------RTQTGGTI-MAGK 126 Query: 765 VASGELKNGFAVVRPPG-HHAEESTAMGFCFFNSVAITAKYLRDQLN-ISKILIVDLDVH 822 +A ++ G+A+ G HH GFC + + + K+L +++ IS+ I+DLD H Sbjct: 127 LA---VERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAH 183 Query: 823 HGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPM 882 GNG ++ F D + + ++ + +PG + + + W G + Sbjct: 184 QGNGHERDFMDDKRVYIMDVY---NRHIYPGDRFAKQ-----AIRRKVELEW--GTE--- 230 Query: 883 GDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMT 942 D EYL+ +K +E PD+V+ +AG D LEG LGG ++ + + Sbjct: 231 -DDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDR--LGGLSISPAGIVKRDELVFR 287 Query: 943 LADGR---VVLALEGGH 956 + GR +++ GG+ Sbjct: 288 MVRGRRVPILMVTSGGY 304 >gi|209862883 histone deacetylase 11 isoform 2 [Homo sapiens] Length = 296 Score = 67.4 bits (163), Expect = 7e-11 Identities = 73/313 (23%), Positives = 129/313 (41%), Gaps = 66/313 (21%) Query: 649 GNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLD 708 G HP AG+ + + L+E LL+ ++ R+AS E++ +VH+ + N L Sbjct: 2 GLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRY-----LNELK 56 Query: 709 GQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASG 768 + L P R G I +A K+A Sbjct: 57 RKVLRP------------------------------------LRTQTGGTI-MAGKLA-- 77 Query: 769 ELKNGFAVVRPPG-HHAEESTAMGFCFFNSVAITAKYLRDQLN-ISKILIVDLDVHHGNG 826 ++ G+A+ G HH GFC + + + K+L +++ IS+ I+DLD H GNG Sbjct: 78 -VERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNG 136 Query: 827 TQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVE 886 ++ F D + + ++ + +PG + + + W G + D E Sbjct: 137 HERDFMDDKRVYIMDVY---NRHIYPGDRFAKQ-----AIRRKVELEW--GTE----DDE 182 Query: 887 YLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADG 946 YL+ +K +E PD+V+ +AG D LEG LGG ++ + + + G Sbjct: 183 YLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDR--LGGLSISPAGIVKRDELVFRMVRG 240 Query: 947 R---VVLALEGGH 956 R +++ GG+ Sbjct: 241 RRVPILMVTSGGY 253 >gi|221139761 zinc finger protein 853 [Homo sapiens] Length = 659 Score = 59.3 bits (142), Expect = 2e-08 Identities = 42/111 (37%), Positives = 65/111 (58%), Gaps = 11/111 (9%) Query: 45 QLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHI----KELLAIKQQQELL 100 Q QQ+LLL+QQQ Q+Q+QLL + + + L Q QAQLQ+ + +E L +QQQ+LL Sbjct: 236 QQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLL 295 Query: 101 EKEQKL--EQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149 +++Q+ +QQ Q +E E+ L D G E+ E++Q+ QE Sbjct: 296 QQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQ-----ELEQQRQE 341 Score = 57.0 bits (136), Expect = 9e-08 Identities = 30/92 (32%), Positives = 59/92 (64%), Gaps = 2/92 (2%) Query: 33 MMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLA 92 + P + + +++QLQ + +Q+QQ++Q+Q + Q+ E Q Q QLQ+ ++E Sbjct: 146 LKPELQLMHQQQQLQPQQ--VQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQL 203 Query: 93 IKQQQELLEKEQKLEQQRQEQEVERHRREQQL 124 ++QQQE L+++Q L+QQ Q Q+ + ++++QL Sbjct: 204 LQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQL 235 Score = 55.8 bits (133), Expect = 2e-07 Identities = 64/275 (23%), Positives = 113/275 (41%), Gaps = 38/275 (13%) Query: 335 PAVPSQLNASNSLKE----KQKCETQTLRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNS 390 PAV + + AS +E +++ + Q L Q P P Q PH+ L+ +P Sbjct: 67 PAVSAPVGASEIAEETRPGQRELQLQQLEQQ-PEPQQQPQHEQLQQPQPHLELQQQPQQD 125 Query: 391 SHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQ 450 Q L Q L+++ Q +H Q + P ++ H+ + +P + Sbjct: 126 GQQQLSQ---LQQEKHQS---------VHHQE-------LKPELQLMHQQQQLQPQQVQE 166 Query: 451 SAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQ 510 L Q Q Q QQ L++Q+Q QQQ+ +LL + EQL+Q L + +E+LQ Sbjct: 167 QQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQ--QQLLQQQEQLQ 224 Query: 511 GDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAA 570 Q Q+ + + GQ+ ++ + + AQ+Q+ +Q A Sbjct: 225 QQQFQQQQ------EQLQQQQQLLLLQQQGQL------QQQLLQQQQAQLQQQLLEQQQA 272 Query: 571 FMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRL 605 +QQ L + +Q L + L++ +L Sbjct: 273 QLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQL 307 Score = 54.7 bits (130), Expect = 5e-07 Identities = 35/99 (35%), Positives = 63/99 (63%), Gaps = 10/99 (10%) Query: 42 REKQLQQELLLIQQQQQIQKQ---LLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQE 98 +++QLQQ+ QQQ+Q+Q+Q LL+ + + + L +Q QAQLQ+ + E + QQ+ Sbjct: 219 QQEQLQQQQFQ-QQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQ 277 Query: 99 LLEKEQKLEQQRQEQEVERHRREQ------QLPPLRGKD 131 LL ++Q+ QQ+Q+Q++ + ++EQ Q PPL ++ Sbjct: 278 LLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEE 316 Score = 53.1 bits (126), Expect = 1e-06 Identities = 39/101 (38%), Positives = 60/101 (59%), Gaps = 19/101 (18%) Query: 42 REKQLQQELLLIQQQQQIQKQLLIAE----FQKQHENLTRQHQAQLQEHIKELLAIKQQQ 97 ++ QLQQ+L L QQQ Q+Q+QLL+ + Q+Q + L +Q Q QLQ+ + ++ ++ Sbjct: 258 QQAQLQQQL-LEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEE 316 Query: 98 EL----------LEKEQKLEQQRQE----QEVERHRREQQL 124 E L EQ+LEQQRQE QE+ER + ++QL Sbjct: 317 EEEVELELMPVDLGSEQELEQQRQELERQQELERQQEQRQL 357 Score = 48.9 bits (115), Expect = 3e-05 Identities = 34/112 (30%), Positives = 66/112 (58%), Gaps = 20/112 (17%) Query: 43 EKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEK 102 + Q QE ++QQQ+Q+Q+Q+ Q + L +Q Q QL QQQ+LL++ Sbjct: 178 QTQQAQEQQVLQQQEQLQQQV-------QEQQLLQQQQEQL-----------QQQQLLQQ 219 Query: 103 EQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSK 154 +++L+QQ+ +Q+ E+ +++QQL L + +G+ + + + +LQ+ LL + Sbjct: 220 QEQLQQQQFQQQQEQLQQQQQL--LLLQQQGQLQQQLLQQQQAQLQQQLLEQ 269 Score = 46.6 bits (109), Expect = 1e-04 Identities = 38/130 (29%), Positives = 68/130 (52%), Gaps = 28/130 (21%) Query: 43 EKQLQQELLLIQQQQQIQKQLL------------------------IAEFQKQHENLTRQ 78 ++Q QQ+LL QQQ+Q+Q+Q L E ++Q + L RQ Sbjct: 287 QQQQQQQLLQ-QQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQ 345 Query: 79 HQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAV 138 + + Q+ ++ L +K Q+EL + EQ+LEQ Q+Q++E+ + +L P+ + +E + Sbjct: 346 QELERQQEQRQ-LQLKLQEELQQLEQQLEQ--QQQQLEQQEVQLELTPVELGAQQQEVQL 402 Query: 139 ASTEVKQKLQ 148 T V+ +LQ Sbjct: 403 ELTPVQPELQ 412 Score = 43.9 bits (102), Expect = 8e-04 Identities = 33/106 (31%), Positives = 60/106 (56%), Gaps = 9/106 (8%) Query: 47 QQELLLIQQQ--QQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQ 104 QQ+L +QQ+ Q + Q L E Q H+ Q Q Q Q+ ++E ++QQQE L+ +Q Sbjct: 127 QQQLSQLQQEKHQSVHHQELKPELQLMHQ----QQQLQPQQ-VQEQQRLQQQQEQLQTQQ 181 Query: 105 KLEQQ--RQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQ 148 EQQ +Q++++++ +EQQL + + +++ + E Q+ Q Sbjct: 182 AQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQ 227 Score = 39.3 bits (90), Expect = 0.020 Identities = 37/121 (30%), Positives = 62/121 (51%), Gaps = 14/121 (11%) Query: 39 PVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQL--QEHIKELLAIKQQ 96 P RE QLQQ ++QQ + Q+Q + Q+ +L Q Q Q Q+ + +L K Q Sbjct: 84 PGQRELQLQQ----LEQQPEPQQQPQHEQLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQ 139 Query: 97 ----QELLEKEQKLEQQRQ---EQEVERHRREQQLPPLRGKDRGRERAVASTE-VKQKLQ 148 QEL + Q + QQ+Q +Q E+ R +QQ L+ + ++ + E ++Q++Q Sbjct: 140 SVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQ 199 Query: 149 E 149 E Sbjct: 200 E 200 Score = 35.0 bits (79), Expect = 0.38 Identities = 33/141 (23%), Positives = 61/141 (43%), Gaps = 16/141 (11%) Query: 393 QALLQHLLLKEQMRQ--QKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQ 450 Q LQ LL++Q Q Q+LL L Q L +E++ + + L + Q Sbjct: 247 QGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQ 306 Query: 451 SAPLPQSTLAQLVIQ--------------QQHQQFLEKQKQYQQQIHMNKLLSKSIEQLK 496 P P + ++ +Q +Q LE+Q++ ++Q +L K E+L+ Sbjct: 307 LQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQELERQQEQRQLQLKLQEELQ 366 Query: 497 QPGSHLEEAEEELQGDQAMQE 517 Q LE+ +++L+ + E Sbjct: 367 QLEQQLEQQQQQLEQQEVQLE 387 Score = 32.0 bits (71), Expect = 3.2 Identities = 43/167 (25%), Positives = 75/167 (44%), Gaps = 23/167 (13%) Query: 393 QALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHK--------LPRHR 444 Q LLQ +EQ++QQ+L PL P+ + + P G+ + L R + Sbjct: 292 QQLLQQQ--QEQLQQQQLQPP---PLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQ 346 Query: 445 PLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKL-LSKSIEQLKQPGSHLE 503 L R Q + QL +Q++ QQ ++ +Q QQQ+ ++ L + +L G+ + Sbjct: 347 ELERQQ-----EQRQLQLKLQEELQQLEQQLEQQQQQLEQQEVQLELTPVEL---GAQQQ 398 Query: 504 EAEEELQGDQ-AMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKE 549 E + EL Q +Q + P++G + A + G V V+E Sbjct: 399 EVQLELTPVQPELQLELVPAAGGGGAAVPGAPAAVVVAPPGYVVVQE 445 >gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] Length = 1303 Score = 55.8 bits (133), Expect = 2e-07 Identities = 69/284 (24%), Positives = 120/284 (42%), Gaps = 46/284 (16%) Query: 43 EKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEK 102 E L++E L +QQ+ + + L KQ + L +Q Q + HIK LL +Q++ +K Sbjct: 348 ESTLRREFLRLQQENKSNSEAL-----KQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQK 402 Query: 103 EQKL---EQQRQE------QEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLS 153 E++ EQQR+E QE E+ RR + + LR ++ R +A E K+K E Sbjct: 403 EERRRVEEQQRREREQRKLQEKEQQRRLEDMQALR-REEERRQAEREQEYKRKQLE---- 457 Query: 154 KSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDF 213 + S +L A+ SL Q + LPG + + Sbjct: 458 ----------EQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHY 507 Query: 214 -----PLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVT---ESS 265 P K A ++ R+R+ ++++SPL + K G+ T + + + + Sbjct: 508 GRGMNPADKPAWAREVEERTRMN----KQQNSPLAKSKPGS--TGPEPPIPQASPGPPGP 561 Query: 266 VSSSSPGSGPSSPNNGPTGSVTENETSVLP---PTPHAEQMVSQ 306 +S + P P P GP S+ + + P P P ++ + Q Sbjct: 562 LSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQ 605 Score = 34.3 bits (77), Expect = 0.64 Identities = 19/92 (20%), Positives = 52/92 (56%), Gaps = 11/92 (11%) Query: 42 REKQLQQELLLIQQQQQIQKQL----LIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQ 97 R+ + + LL Q+Q++I++Q + E Q++ + + + Q ++++ A+++++ Sbjct: 381 RDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREE 440 Query: 98 ELLE-------KEQKLEQQRQEQEVERHRREQ 122 E + K ++LE+QRQ + ++R +++ Sbjct: 441 ERRQAEREQEYKRKQLEEQRQSERLQRQLQQE 472 Score = 31.2 bits (69), Expect = 5.4 Identities = 22/94 (23%), Positives = 51/94 (54%), Gaps = 10/94 (10%) Query: 40 VVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQEL 99 V +++ ++E +Q+++Q Q + + Q R+ + QE+ ++ L ++Q E Sbjct: 408 VEEQQRREREQRKLQEKEQ---QRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSER 464 Query: 100 LEKEQKLE-------QQRQEQEVERHRREQQLPP 126 L+++ + E QQ+Q+Q+ + +++QQL P Sbjct: 465 LQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLP 498 >gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] Length = 1332 Score = 55.8 bits (133), Expect = 2e-07 Identities = 69/284 (24%), Positives = 120/284 (42%), Gaps = 46/284 (16%) Query: 43 EKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEK 102 E L++E L +QQ+ + + L KQ + L +Q Q + HIK LL +Q++ +K Sbjct: 348 ESTLRREFLRLQQENKSNSEAL-----KQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQK 402 Query: 103 EQKL---EQQRQE------QEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLS 153 E++ EQQR+E QE E+ RR + + LR ++ R +A E K+K E Sbjct: 403 EERRRVEEQQRREREQRKLQEKEQQRRLEDMQALR-REEERRQAEREQEYKRKQLE---- 457 Query: 154 KSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDF 213 + S +L A+ SL Q + LPG + + Sbjct: 458 ----------EQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHY 507 Query: 214 -----PLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVT---ESS 265 P K A ++ R+R+ ++++SPL + K G+ T + + + + Sbjct: 508 GRGMNPADKPAWAREVEERTRMN----KQQNSPLAKSKPGS--TGPEPPIPQASPGPPGP 561 Query: 266 VSSSSPGSGPSSPNNGPTGSVTENETSVLP---PTPHAEQMVSQ 306 +S + P P P GP S+ + + P P P ++ + Q Sbjct: 562 LSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQ 605 Score = 34.3 bits (77), Expect = 0.64 Identities = 19/92 (20%), Positives = 52/92 (56%), Gaps = 11/92 (11%) Query: 42 REKQLQQELLLIQQQQQIQKQL----LIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQ 97 R+ + + LL Q+Q++I++Q + E Q++ + + + Q ++++ A+++++ Sbjct: 381 RDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREE 440 Query: 98 ELLE-------KEQKLEQQRQEQEVERHRREQ 122 E + K ++LE+QRQ + ++R +++ Sbjct: 441 ERRQAEREQEYKRKQLEEQRQSERLQRQLQQE 472 Score = 31.2 bits (69), Expect = 5.4 Identities = 22/94 (23%), Positives = 51/94 (54%), Gaps = 10/94 (10%) Query: 40 VVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQEL 99 V +++ ++E +Q+++Q Q + + Q R+ + QE+ ++ L ++Q E Sbjct: 408 VEEQQRREREQRKLQEKEQ---QRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSER 464 Query: 100 LEKEQKLE-------QQRQEQEVERHRREQQLPP 126 L+++ + E QQ+Q+Q+ + +++QQL P Sbjct: 465 LQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLP 498 >gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] Length = 1295 Score = 55.8 bits (133), Expect = 2e-07 Identities = 69/284 (24%), Positives = 120/284 (42%), Gaps = 46/284 (16%) Query: 43 EKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEK 102 E L++E L +QQ+ + + L KQ + L +Q Q + HIK LL +Q++ +K Sbjct: 348 ESTLRREFLRLQQENKSNSEAL-----KQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQK 402 Query: 103 EQKL---EQQRQE------QEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLS 153 E++ EQQR+E QE E+ RR + + LR ++ R +A E K+K E Sbjct: 403 EERRRVEEQQRREREQRKLQEKEQQRRLEDMQALR-REEERRQAEREQEYKRKQLE---- 457 Query: 154 KSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDF 213 + S +L A+ SL Q + LPG + + Sbjct: 458 ----------EQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHY 507 Query: 214 -----PLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVT---ESS 265 P K A ++ R+R+ ++++SPL + K G+ T + + + + Sbjct: 508 GRGMNPADKPAWAREVEERTRMN----KQQNSPLAKSKPGS--TGPEPPIPQASPGPPGP 561 Query: 266 VSSSSPGSGPSSPNNGPTGSVTENETSVLP---PTPHAEQMVSQ 306 +S + P P P GP S+ + + P P P ++ + Q Sbjct: 562 LSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQ 605 Score = 34.3 bits (77), Expect = 0.64 Identities = 19/92 (20%), Positives = 52/92 (56%), Gaps = 11/92 (11%) Query: 42 REKQLQQELLLIQQQQQIQKQL----LIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQ 97 R+ + + LL Q+Q++I++Q + E Q++ + + + Q ++++ A+++++ Sbjct: 381 RDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREE 440 Query: 98 ELLE-------KEQKLEQQRQEQEVERHRREQ 122 E + K ++LE+QRQ + ++R +++ Sbjct: 441 ERRQAEREQEYKRKQLEEQRQSERLQRQLQQE 472 Score = 31.2 bits (69), Expect = 5.4 Identities = 22/94 (23%), Positives = 51/94 (54%), Gaps = 10/94 (10%) Query: 40 VVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQEL 99 V +++ ++E +Q+++Q Q + + Q R+ + QE+ ++ L ++Q E Sbjct: 408 VEEQQRREREQRKLQEKEQ---QRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSER 464 Query: 100 LEKEQKLE-------QQRQEQEVERHRREQQLPP 126 L+++ + E QQ+Q+Q+ + +++QQL P Sbjct: 465 LQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLP 498 >gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens] Length = 748 Score = 55.8 bits (133), Expect = 2e-07 Identities = 91/395 (23%), Positives = 156/395 (39%), Gaps = 88/395 (22%) Query: 15 PVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHEN 74 P + +S +T L++ + +++Q QQ+ QQQQ Q+Q +FQ Q Sbjct: 138 PHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQ--QQFQAQQSA 195 Query: 75 LTRQHQA------------QLQEHIKEL-----LAIKQQQELLEKEQKLEQQRQEQEVER 117 + +Q QA Q Q+H+ +L I+QQQ+ L++ +L+ Q+Q+Q+ ++ Sbjct: 196 MQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQQ 255 Query: 118 HRREQQ-----LPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRH 172 +++QQ PP++ + + S + Q+LQ+ + ++H Sbjct: 256 QQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQM-----------HHTQHHQPPPQ 304 Query: 173 PKLWYTAAHHTSLDQSSPPLSGTSP--SYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRL 230 P+ A + S PP S T P S LPG + ++P LK R Sbjct: 305 PQQPPVAQNQPS---QLPPQSQTQPLVSQAQALPG----------QMLYTQPPLKF-VRA 350 Query: 231 KQKVAERRSSPLLRRKDGNVVTSFKKRM----FEVTESS---VSSSSPGSGPSSPNNGPT 283 V + P ++++ V T+ +M +V++SS +SS SPG +P + Sbjct: 351 PMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQS--- 407 Query: 284 GSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNA 343 +PP P Q +S N++ G PS Sbjct: 408 ----------MPPPPQPSPQPGQP---------------SSQPNSNVSSGPAPSPSSFLP 442 Query: 344 SNSLKEKQKCETQTLRQ--GVPLPGQYGGSIPASS 376 S S + Q T Q VP PG + SS Sbjct: 443 SPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSS 477 Score = 39.7 bits (91), Expect = 0.015 Identities = 100/483 (20%), Positives = 168/483 (34%), Gaps = 114/483 (23%) Query: 34 MPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAI 93 M VV + QLQ + + +QQQQQ Q +FQ+Q + +Q Q Q Sbjct: 141 MAVVSTATPQTQLQLQQVALQQQQQQQ------QFQQQQQAALQQQQQQ----------- 183 Query: 94 KQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLS 153 QQQ+ + +Q QQ+ + V++ +QQL + +Q+ Q+ L+ Sbjct: 184 -QQQQQFQAQQSAMQQQFQAVVQQ---QQQL-----------------QQQQQQQQHLIK 222 Query: 154 KSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDF 213 + + R +L L Q + L AQ Sbjct: 223 LHHQNQQQIQQQQQQLQRIAQL--------QLQQQQQQQQQQQQQQQQALQ-AQPPIQQP 273 Query: 214 PLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGS 273 P+++ P+ + +L+Q + P Sbjct: 274 PMQQPQPPPSQALPQQLQQMHHTQHHQP-------------------------------- 301 Query: 274 GPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLG 333 P P P V +N+ S LPP + +VSQ + L + LYT P L + Sbjct: 302 -PPQPQQPP---VAQNQPSQLPPQSQTQPLVSQAQALPGQ------MLYTQPPLKFVRA- 350 Query: 334 LPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQY--GGSIPASSSHPHVTLEGKPPNSS 391 P V Q ++++Q + PG S+P SS P + + P S Sbjct: 351 -PMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSS-PSPGQQVQTPQSM 408 Query: 392 HQALLQHLLLKEQMRQQKLLVAGGVPLHPQS------PLATKERISPGIRGTHKLPRHRP 445 + Q V+ G P S P ++ ++ +P P Sbjct: 409 PPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGP 468 Query: 446 LNRTQSAPLPQSTLAQLVIQQ-QHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEE 504 LN + P S ++ Q + QQ+L+K KQ LSK IE L++ + +++ Sbjct: 469 LNTPVN---PSSVMSPAGSSQAEEQQYLDKLKQ----------LSKYIEPLRRMINKIDK 515 Query: 505 AEE 507 E+ Sbjct: 516 NED 518 Score = 37.0 bits (84), Expect = 0.099 Identities = 46/221 (20%), Positives = 86/221 (38%), Gaps = 23/221 (10%) Query: 436 GTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQ--FLEKQK---QYQQQIHMNKLLSK 490 GT + H + + P Q L Q+ +QQQ QQ F ++Q+ Q QQQ + Sbjct: 132 GTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQA 191 Query: 491 SIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEE 550 ++Q + + +++LQ Q Q+ + + L ++ ++++++ Sbjct: 192 QQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQ--QQQLQRIAQLQLQQQ 249 Query: 551 PVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTH 610 + Q Q+ Q Q P +P + P A+ + H ++ H Sbjct: 250 QQQQQQQQQQQQQALQAQPPIQQPPMQQP--------QPPPSQALPQQLQQMHH--TQHH 299 Query: 611 SSPAASVLPHPAMDRP--LQPGSATGIAYDPLMLKHQCVCG 649 P P A ++P L P S T PL+ + Q + G Sbjct: 300 QPPPQPQQPPVAQNQPSQLPPQSQT----QPLVSQAQALPG 336 >gi|17017963 forkhead box P2 isoform I [Homo sapiens] Length = 715 Score = 55.1 bits (131), Expect = 4e-07 Identities = 48/187 (25%), Positives = 90/187 (48%), Gaps = 17/187 (9%) Query: 23 PLDLRTDLRMMMP-VVDPVVREKQLQQELL-------LIQQQQQI--QKQLLIAEFQKQH 72 PL + + MM P V+ P ++ LQQ++L L+QQQQ + Q+Q L ++KQ Sbjct: 84 PLQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQ 143 Query: 73 ENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDR 132 E L Q Q Q+ + QQQ+ +++Q+ +QQ+Q+Q+ ++ +++QQ GK Sbjct: 144 EQLHLQLLQQQQQQQQ------QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQA 197 Query: 133 GRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVS-RHPKLWYTAAHHTSLDQSSPP 191 ++ + + Q+ + + + + H +S + L +L S P Sbjct: 198 KEQQQQQQQQQQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLP 257 Query: 192 LSGTSPS 198 +G SP+ Sbjct: 258 QAGLSPA 264 Score = 40.0 bits (92), Expect = 0.012 Identities = 49/236 (20%), Positives = 98/236 (41%), Gaps = 13/236 (5%) Query: 424 LATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIH 483 + T + I+P + ++ + + L+ Q L Q A ++ QQQ Q+F +KQ Q+Q+H Sbjct: 93 MMTPQVITP--QQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQ---QEQLH 147 Query: 484 MNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVG 543 + L + +Q +Q ++ +++ Q Q Q+ + A Q Sbjct: 148 LQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQ 207 Query: 544 AVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFL--EPTHTRALSVRQAPLAAVGMDGLE 601 ++ V + Q+Q+++ + +Q+ L P AL V+ P A + ++ Sbjct: 208 QQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQ 267 Query: 602 K-HRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIA----YDPLMLKHQCVCGNST 652 + + V+ HS + H +D S+T + P + H V G S+ Sbjct: 268 QLWKEVTGVHSMEDNGI-KHGGLDLTTNNSSSTTSSNTSKASPPITHHSIVNGQSS 322 >gi|148746195 trichohyalin [Homo sapiens] Length = 1943 Score = 53.9 bits (128), Expect = 8e-07 Identities = 44/199 (22%), Positives = 95/199 (47%), Gaps = 17/199 (8%) Query: 43 EKQLQQELL---LIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQEL 99 EK+L+QE L ++Q++ + QLL E +++ + L R+ + +L++ +K +++ E Sbjct: 555 EKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLK-----REEVER 609 Query: 100 LEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKD 159 LE+E++ EQ+ + +E E RR+Q L ++R R++ + + +++ Q + + Sbjct: 610 LEQEERREQRLKREEPEEERRQQLLKSEEQEER-RQQQLRREQQERREQRLKREEEEERL 668 Query: 160 TPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTA 219 + H R + +Q+ + P +++ L DA+ K Sbjct: 669 EQRLKREHEEERREQ----ELAEEEQEQARERIKSRIPKWQWQLESEADARQS----KVY 720 Query: 220 SEPNLKVRSRLKQKVAERR 238 S P + R +Q+ E+R Sbjct: 721 SRPRKQEGQRRRQEQEEKR 739 Score = 50.1 bits (118), Expect = 1e-05 Identities = 40/117 (34%), Positives = 66/117 (56%), Gaps = 10/117 (8%) Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101 RE+QL++E L ++QQ ++Q L E Q + E R+ Q +E +E K +QE E Sbjct: 385 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERRE 444 Query: 102 KEQKLEQQ------RQEQEVERH---RREQQLPPLRGKDRGRERAVASTEVKQKLQE 149 + K EQ+ ++E+E ERH RR+QQL + ++R RER + E +++ Q+ Sbjct: 445 QRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEER-RERWLKLEEEERREQQ 500 Score = 49.7 bits (117), Expect = 1e-05 Identities = 27/83 (32%), Positives = 54/83 (65%), Gaps = 1/83 (1%) Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQ-KQHENLTRQHQAQLQEHIKELLAIKQQQELL 100 RE+QL++E L ++QQ ++Q L E Q ++ + L R+ Q + ++ ++ ++++QE Sbjct: 373 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEE 432 Query: 101 EKEQKLEQQRQEQEVERHRREQQ 123 EQK EQ+R+EQ ++R + E++ Sbjct: 433 RHEQKHEQERREQRLKREQEERR 455 Score = 47.0 bits (110), Expect = 1e-04 Identities = 37/129 (28%), Positives = 67/129 (51%), Gaps = 18/129 (13%) Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101 RE+QL++E L ++QQ ++Q QK + Q + QE ++ L +++ E E Sbjct: 409 REQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHE 468 Query: 102 KEQKLEQQRQEQEVER----------------HRREQQLPPLRGKDRGRERAVASTEVKQ 145 +E++ +Q +++QE ER RREQQL R ++ RE+ + E ++ Sbjct: 469 QERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQL--RREQEERREQRLKRQEEEE 526 Query: 146 KLQEFLLSK 154 +LQ+ L S+ Sbjct: 527 RLQQRLRSE 535 Score = 44.7 bits (104), Expect = 5e-04 Identities = 29/111 (26%), Positives = 66/111 (59%), Gaps = 5/111 (4%) Query: 43 EKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIK--ELLAIKQQQELL 100 E++LQ+E Q++ Q +++ L + ++Q RQ + Q Q+ ++ + L KQ++E Sbjct: 257 EEKLQEEEPQRQRELQEEEEQL-RKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERR 315 Query: 101 EKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFL 151 E++++ +Q++ +E + RREQQL R ++ RE+ + + +++ ++ L Sbjct: 316 EQQEERREQQERREQQEERREQQL--RREQEERREQQLRREQEEERREQQL 364 Score = 44.3 bits (103), Expect = 6e-04 Identities = 37/211 (17%), Positives = 96/211 (45%), Gaps = 21/211 (9%) Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQ--KQHENLTRQHQAQLQEHIKELLAIKQQQEL 99 RE+QL++E +++QQ++++ + Q ++ + L R+ Q + ++ ++ ++++Q+L Sbjct: 360 REQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 419 Query: 100 LEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKD 159 ++Q +Q +E+ ++H +E++ L+ + R + E ++ ++ + +D Sbjct: 420 RREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRD 479 Query: 160 TPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTA 219 + W +Q + L Q+ + + L++ Sbjct: 480 QEEERRER--------WLKLEEEERREQQE--------RREQQLRREQEERREQRLKRQE 523 Query: 220 SEPNLKVRSRLKQKV---AERRSSPLLRRKD 247 E L+ R R +Q++ E R LL+R++ Sbjct: 524 EEERLQQRLRSEQQLRREQEERREQLLKREE 554 Score = 43.9 bits (102), Expect = 8e-04 Identities = 32/131 (24%), Positives = 72/131 (54%), Gaps = 7/131 (5%) Query: 19 EPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQ 78 EP +L+ + + + +R ++ ++E QQQQ+++++ + Q++ ++ Sbjct: 264 EPQRQRELQEEEEQLRKLERQELRRERQEEE----QQQQRLRREQQLRRKQEEERREQQE 319 Query: 79 HQAQLQEHIKELLAIKQQQELLEKEQKLEQQ-RQEQEVERHRREQQLPPLRGKDRGRERA 137 + + QE ++ ++QQ E+E++ EQQ R+EQE ER REQQL + ++R ++ Sbjct: 320 ERREQQERREQQEERREQQLRREQEERREQQLRREQEEER--REQQLRREQEEERREQQL 377 Query: 138 VASTEVKQKLQ 148 +++++ Q Sbjct: 378 RREQQLRREQQ 388 Score = 43.9 bits (102), Expect = 8e-04 Identities = 32/113 (28%), Positives = 65/113 (57%), Gaps = 8/113 (7%) Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101 R+++LQ+E +Q +++++Q L E Q++ + R + Q +E +QQ+E E Sbjct: 267 RQRELQEEE---EQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERRE 323 Query: 102 KEQKLEQQ--RQEQEVERH---RREQQLPPLRGKDRGRERAVASTEVKQKLQE 149 ++++ EQQ R+EQ++ R RREQQL + ++R ++ E +++ Q+ Sbjct: 324 QQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQ 376 Score = 43.1 bits (100), Expect = 0.001 Identities = 35/139 (25%), Positives = 71/139 (51%), Gaps = 33/139 (23%) Query: 44 KQLQQELLLIQQQQQIQKQLLIAEFQKQHE--NLTRQHQAQLQEHIKELLAIKQ------ 95 ++ ++E +Q++QQ+++Q L +F+++ + T Q Q + QE +++L +Q Sbjct: 1701 RRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPERE 1760 Query: 96 QQEL--------LEKEQKLEQQRQEQEVE---------------RHRREQQLPPLR--GK 130 +Q+L +E++L Q+R+EQ++ + R EQQL P + GK Sbjct: 1761 EQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGK 1820 Query: 131 DRGRERAVASTEVKQKLQE 149 R E + E +Q+L++ Sbjct: 1821 YRWEEEQLQLEEQEQRLRQ 1839 Score = 42.0 bits (97), Expect = 0.003 Identities = 27/123 (21%), Positives = 69/123 (56%), Gaps = 10/123 (8%) Query: 42 REKQL--QQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQEL 99 RE++L Q+E +QQ+ + ++QL + +++ + L R+ + +L++ +E ++Q+E Sbjct: 515 REQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEER 574 Query: 100 LEKEQKLEQQRQEQEVERHRRE--------QQLPPLRGKDRGRERAVASTEVKQKLQEFL 151 ++ K E++R++Q ++R + E +++ L ++R +R +++ Q+ L Sbjct: 575 RDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLL 634 Query: 152 LSK 154 S+ Sbjct: 635 KSE 637 Score = 42.0 bits (97), Expect = 0.003 Identities = 26/85 (30%), Positives = 56/85 (65%), Gaps = 6/85 (7%) Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQH-ENLTRQH--QAQLQEHIKELLAIKQQQE 98 R ++L+++ ++ QQ ++QLL E +K+ + L RQ+ + +LQ+ ++LL +Q++ Sbjct: 1132 RRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKR 1191 Query: 99 LLEKEQKLEQQRQEQEVERHRREQQ 123 E+E+ Q R+E+E++R +R+Q+ Sbjct: 1192 RQERER---QYREEEELQRQKRKQR 1213 Score = 41.6 bits (96), Expect = 0.004 Identities = 27/98 (27%), Positives = 62/98 (63%), Gaps = 10/98 (10%) Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101 RE+QL++E +++QQ++++ E +++ + L R+ Q + ++ ++ ++++Q+L Sbjct: 347 REQQLRREQEEERREQQLRRE---QEEERREQQLRREQQLRREQQLRREQQLRREQQL-R 402 Query: 102 KEQKLEQQRQEQEVERH---RREQQLPPLRGKDRGRER 136 +EQ+L R+EQ++ R RREQQL + ++R ++ Sbjct: 403 REQQL---RREQQLRREQQLRREQQLRREQEEERHEQK 437 Score = 41.6 bits (96), Expect = 0.004 Identities = 28/109 (25%), Positives = 67/109 (61%), Gaps = 15/109 (13%) Query: 54 QQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQ---------QELL--EK 102 +QQ++ ++QL + +++ + L RQ + +E +++ L +QQ ++LL E+ Sbjct: 498 EQQERREQQLRREQEERREQRLKRQEE---EERLQQRLRSEQQLRREQEERREQLLKREE 554 Query: 103 EQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFL 151 E++LEQ+R+EQ ++R + E++ L+ ++ R++ + E +++L++ L Sbjct: 555 EKRLEQERREQRLKREQEERRDQLLKREEERRQQRL-KREQEERLEQRL 602 Score = 41.6 bits (96), Expect = 0.004 Identities = 25/100 (25%), Positives = 59/100 (59%), Gaps = 5/100 (5%) Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKE----LLAIKQQQ 97 RE++ +Q+ L +Q+++++++L E ++ + R+ + + +E +E LL ++Q+ Sbjct: 581 REEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQE 640 Query: 98 ELLEKEQKLEQQ-RQEQEVERHRREQQLPPLRGKDRGRER 136 E +++ + EQQ R+EQ ++R E++L ++ ER Sbjct: 641 ERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEER 680 Score = 41.6 bits (96), Expect = 0.004 Identities = 32/120 (26%), Positives = 69/120 (57%), Gaps = 13/120 (10%) Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101 R+ + +++LL +++QQ+ +Q +F ++ + L RQ + + +EL + + +++ LE Sbjct: 1461 RKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFRE-QELRSQEPERKFLE 1519 Query: 102 KEQKLEQQR-------QEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSK 154 +EQ+L +Q+ +EQ++ R R QQ R +DR R + +++Q+ +E LS+ Sbjct: 1520 EEQQLHRQQRQRKFLQEEQQLRRQERGQQ----RRQDRDR-KFREEEQLRQEREEQQLSR 1574 Score = 41.6 bits (96), Expect = 0.004 Identities = 27/114 (23%), Positives = 59/114 (51%), Gaps = 11/114 (9%) Query: 38 DPVVREKQLQQ---ELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIK 94 D RE++L+ E ++++QQ+ +Q +F ++ + L RQ + Q + + Sbjct: 1500 DRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRR--------Q 1551 Query: 95 QQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQ 148 + +E++L Q+R+EQ++ R R+++ K R +E+ E +Q+L+ Sbjct: 1552 DRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLR 1605 Score = 40.8 bits (94), Expect = 0.007 Identities = 25/91 (27%), Positives = 54/91 (59%), Gaps = 6/91 (6%) Query: 47 QQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKL 106 ++E L +++Q+Q +Q +++ + E Q +++ +E +EL ++Q+ E+E+KL Sbjct: 1824 EEEQLQLEEQEQRLRQERDRQYRAE-EQFATQEKSRREE--QELWQEEEQKRRQERERKL 1880 Query: 107 EQQ---RQEQEVERHRREQQLPPLRGKDRGR 134 ++ RQ++E +RHR+ ++ GK GR Sbjct: 1881 REEHIRRQQKEEQRHRQVGEIKSQEGKGHGR 1911 Score = 40.4 bits (93), Expect = 0.009 Identities = 34/125 (27%), Positives = 64/125 (51%), Gaps = 12/125 (9%) Query: 45 QLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHI-KELLAIKQQQELLEKE 103 Q QE Q+Q++ QK E +++ T + LQE + KE +++++E L++E Sbjct: 857 QEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQRE 916 Query: 104 QKLEQQRQEQEVERHRREQQLPP----------LRGKDRGRERAVASTEVKQKLQEFLLS 153 ++ +++RQEQE ++R E+QL + + + RER + Q+ +E LL Sbjct: 917 EREKRRRQEQE-RQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLG 975 Query: 154 KSATK 158 + K Sbjct: 976 EEPEK 980 Score = 40.4 bits (93), Expect = 0.009 Identities = 36/119 (30%), Positives = 69/119 (57%), Gaps = 12/119 (10%) Query: 42 REKQLQQELLLIQQ--QQQIQKQLLIAEFQKQHENLTRQHQAQ--LQEHIKELLAIKQQQ 97 R+++ ++E L+Q+ +QQ+++Q +F+++ + L RQ + + LQE ++L + ++ Sbjct: 1665 RDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEE-QQLRRQELER 1723 Query: 98 ELLEKEQKLEQQRQEQ--EVERHRR---EQQLPPLRGKD--RGRERAVASTEVKQKLQE 149 + E+EQ ++ QEQ ER+R+ E+QL P R + R +ER E +Q QE Sbjct: 1724 KFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQE 1782 Score = 40.0 bits (92), Expect = 0.012 Identities = 27/109 (24%), Positives = 60/109 (55%), Gaps = 2/109 (1%) Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQH-QAQLQEHIKELLAIKQQQELL 100 RE L++E +Q+++ Q+Q + E ++Q L RQ + + QE ++ ++++Q+L Sbjct: 249 RETVLRKEEEKLQEEEP-QRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLR 307 Query: 101 EKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149 K+++ +++QE+ E+ R +Q R + RE+ + ++ QE Sbjct: 308 RKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQE 356 Score = 39.7 bits (91), Expect = 0.015 Identities = 34/125 (27%), Positives = 70/125 (56%), Gaps = 19/125 (15%) Query: 43 EKQLQQELLLI------QQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIK-- 94 E+QL++ LL +++QQ +++ FQ++ E R+ + L++ ++L + Sbjct: 207 EEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQ 266 Query: 95 QQQELLEKEQKL----------EQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVK 144 +Q+EL E+E++L E+Q +EQ+ +R RREQQL + ++R RE+ E + Sbjct: 267 RQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEER-REQQEERREQQ 325 Query: 145 QKLQE 149 ++ ++ Sbjct: 326 ERREQ 330 Score = 39.7 bits (91), Expect = 0.015 Identities = 23/83 (27%), Positives = 52/83 (62%), Gaps = 9/83 (10%) Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101 RE+Q ++E QQ+++ ++QL + +++ + L R+ + + +E ++++QE Sbjct: 322 REQQERRE----QQEERREQQLRREQEERREQQLRREQEEERREQ-----QLRREQEEER 372 Query: 102 KEQKLEQQRQEQEVERHRREQQL 124 +EQ+L +++Q + ++ RREQQL Sbjct: 373 REQQLRREQQLRREQQLRREQQL 395 Score = 39.7 bits (91), Expect = 0.015 Identities = 33/135 (24%), Positives = 66/135 (48%), Gaps = 25/135 (18%) Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQA--------------QLQEHI 87 + ++ ++EL +++++Q+Q++ + Q++ + L + QL+E Sbjct: 823 QRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEER 882 Query: 88 KE----LLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEV 143 K L A QE L KEQ+L Q+ +E+E++R RE++ + + +ER E Sbjct: 883 KRRRHTLYAKPALQEQLRKEQQLLQE-EEEELQREEREKR------RRQEQERQYREEEQ 935 Query: 144 KQKLQEFLLSKSATK 158 Q+ +E LL + K Sbjct: 936 LQQEEEQLLREEREK 950 Score = 39.7 bits (91), Expect = 0.015 Identities = 29/123 (23%), Positives = 66/123 (53%), Gaps = 9/123 (7%) Query: 38 DPVVREKQLQQELL-LIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEH--IKELLAIK 94 D +R++Q QQ+L L+ +QQ+ ++ +Q++ + + Q + +E K Sbjct: 1255 DSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKS 1314 Query: 95 QQQELLEKEQKLEQQRQEQEVERHRREQQL------PPLRGKDRGRERAVASTEVKQKLQ 148 Q+++ L +E++ E++R+++ + R E+QL PLR ++R R+ +++ + Sbjct: 1315 QEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGR 1374 Query: 149 EFL 151 +FL Sbjct: 1375 KFL 1377 Score = 39.7 bits (91), Expect = 0.015 Identities = 29/120 (24%), Positives = 63/120 (52%), Gaps = 16/120 (13%) Query: 42 REKQLQQEL--LLIQQQQQIQKQLLIAEFQKQHENLTRQH----------QAQLQEHIKE 89 RE+QL+Q+ +++QQ+ +Q +F+++ + + RQ Q + + H K Sbjct: 1404 REQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRK- 1462 Query: 90 LLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149 +++++LL++ ++ + RQE++ + EQQL + RE+ + S E ++K E Sbjct: 1463 ---FREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLE 1519 Score = 39.3 bits (90), Expect = 0.020 Identities = 23/81 (28%), Positives = 47/81 (58%), Gaps = 2/81 (2%) Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101 R++QL++E ++Q++ +++ +AE ++Q E R Q Q +EL +Q+QE E Sbjct: 125 RDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELW--RQRQEWQE 182 Query: 102 KEQKLEQQRQEQEVERHRREQ 122 +E++ ++ Q Q + H E+ Sbjct: 183 REERRAEEEQLQSCKGHETEE 203 Score = 39.3 bits (90), Expect = 0.020 Identities = 32/112 (28%), Positives = 60/112 (53%), Gaps = 8/112 (7%) Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQ--EHIKELLAIKQQQEL 99 RE+QL+ E ++QQ+ Q+ L E ++Q R+ + +LQ E ++L ++ Q+L Sbjct: 794 RERQLRAE----ERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQL 849 Query: 100 LEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFL 151 E+E L++ ++ + + RR+Q+ ++R R R + K LQE L Sbjct: 850 QEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRR--HTLYAKPALQEQL 899 Score = 39.3 bits (90), Expect = 0.020 Identities = 30/129 (23%), Positives = 69/129 (53%), Gaps = 20/129 (15%) Query: 39 PVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQE 98 P ++E+ +++ LL ++++++Q++ + E RQ Q + +E ++Q++E Sbjct: 893 PALQEQLRKEQQLLQEEEEELQRE--------EREKRRRQEQ---ERQYREEEQLQQEEE 941 Query: 99 LLEKEQKLEQQRQEQEVERHR------REQQL---PPLRGKDRGRERAVASTEVKQKLQE 149 L +E++ +++RQE+E + + +E+QL P + + + RE+ E Q+ +E Sbjct: 942 QLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEE 1001 Query: 150 FLLSKSATK 158 LL + K Sbjct: 1002 QLLREEREK 1010 Score = 39.3 bits (90), Expect = 0.020 Identities = 33/125 (26%), Positives = 66/125 (52%), Gaps = 14/125 (11%) Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101 R ++L+++ ++ QQ ++QLL E +K+ R+ Q + +E +++ ++++LL Sbjct: 1072 RRQELERQYRKEEELQQEEEQLLREEPEKRRRQ-ERERQCREEEELQQ-----EEEQLLR 1125 Query: 102 KE------QKLEQQRQEQEVERHRREQQL--PPLRGKDRGRERAVASTEVKQKLQEFLLS 153 +E Q+LE+Q +E+E + EQ L P + + + ER E Q+ +E LL Sbjct: 1126 EEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLR 1185 Query: 154 KSATK 158 + K Sbjct: 1186 EEQEK 1190 Score = 38.9 bits (89), Expect = 0.026 Identities = 26/88 (29%), Positives = 54/88 (61%), Gaps = 5/88 (5%) Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101 RE+QL+++ +++QQ +++ ++Q E +Q + + +E ++ L +Q++E E Sbjct: 302 REQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERRE 361 Query: 102 KEQKLEQQ--RQEQEVERH---RREQQL 124 ++ + EQ+ R+EQ++ R RREQQL Sbjct: 362 QQLRREQEEERREQQLRREQQLRREQQL 389 Score = 38.9 bits (89), Expect = 0.026 Identities = 22/107 (20%), Positives = 60/107 (56%), Gaps = 2/107 (1%) Query: 43 EKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEK 102 +++ +Q+L Q++++ ++ L + E +++ + R+ Q + ++ + +K+Q+E Sbjct: 469 QERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERL 528 Query: 103 EQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149 +Q+L ++Q + + RREQ L R +++ E+ +K++ +E Sbjct: 529 QQRLRSEQQLRREQEERREQLLK--REEEKRLEQERREQRLKREQEE 573 Score = 38.9 bits (89), Expect = 0.026 Identities = 31/123 (25%), Positives = 66/123 (53%), Gaps = 15/123 (12%) Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIK-------ELLAIK 94 R+ Q +++LL +++++ ++Q +F+++ + L + + L+ + EL + Sbjct: 1312 RKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQE 1371 Query: 95 QQQELLEKEQKLEQQ-------RQEQEVERHRREQQLPPLRG-KDRGRERAVASTEVKQK 146 Q ++ LE+EQ+L +Q ++EQ++ REQQL R K R E+ ++ E +K Sbjct: 1372 QGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRK 1431 Query: 147 LQE 149 +E Sbjct: 1432 FRE 1434 Score = 38.5 bits (88), Expect = 0.034 Identities = 29/115 (25%), Positives = 61/115 (53%), Gaps = 4/115 (3%) Query: 38 DPVVREKQL---QQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIK 94 D RE++L +Q ++++Q++++Q +F K+ + L Q + Q ++ + Sbjct: 1359 DRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFRE 1418 Query: 95 QQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149 ++Q+L +E+ + + +EQ+V R RE++ + R +ER E +Q LQE Sbjct: 1419 EEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLR-QERHRKFREEEQLLQE 1472 Score = 38.1 bits (87), Expect = 0.045 Identities = 26/108 (24%), Positives = 60/108 (55%), Gaps = 2/108 (1%) Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101 +E++ QQE QQ ++ Q++ + +++ E R+ Q + ++ + ++++ L Sbjct: 325 QERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLR 384 Query: 102 KEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149 +EQ+L +++Q + ++ RREQQL R + RE+ + + ++ QE Sbjct: 385 REQQLRREQQLRREQQLRREQQL--RREQQLRREQQLRREQQLRREQE 430 Score = 38.1 bits (87), Expect = 0.045 Identities = 32/107 (29%), Positives = 59/107 (55%), Gaps = 7/107 (6%) Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQH-ENLTRQHQAQLQEHIKELLAIKQQQELL 100 RE+Q ++E ++ QQ ++QLL E +K+ + L RQ++ + + +E ++++ E Sbjct: 1106 RERQCREE----EELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEK- 1160 Query: 101 EKEQKLEQQRQEQEVERHRREQQLPPLRGKDR-GRERAVASTEVKQK 146 + Q+LE+Q +E+E + EQ L + K R RER E Q+ Sbjct: 1161 RRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQR 1207 Score = 37.7 bits (86), Expect = 0.058 Identities = 23/107 (21%), Positives = 58/107 (54%), Gaps = 1/107 (0%) Query: 44 KQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQ-QELLEK 102 ++ +QE ++ +QQ+++Q + +++ + R+ + LQE ++ L +++ ++ LE+ Sbjct: 1589 RRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEE 1648 Query: 103 EQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149 E +L +Q +EQ++ R + + G E+ + E +K +E Sbjct: 1649 EPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFRE 1695 Score = 37.7 bits (86), Expect = 0.058 Identities = 28/116 (24%), Positives = 58/116 (50%), Gaps = 8/116 (6%) Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKE--------LLAI 93 R+ + ++LL +++QQ+ +Q +F ++ L RQ + Q H ++ LL Sbjct: 1619 RKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQE 1678 Query: 94 KQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149 ++Q+L +E+ + + +EQ++ R RE++ + R +E E +Q QE Sbjct: 1679 GEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQE 1734 Score = 37.4 bits (85), Expect = 0.076 Identities = 31/121 (25%), Positives = 61/121 (50%), Gaps = 12/121 (9%) Query: 43 EKQLQQELLLIQQQQQIQK-QLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101 E++ +QEL +Q+Q ++ + I ++Q Q E+ Q+++ ++ +++QE E Sbjct: 678 EERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEE 737 Query: 102 KEQKLEQQRQEQEVERHRREQQLPPLR-----------GKDRGRERAVASTEVKQKLQEF 150 K ++ E + Q QE ER R+QQ R +RGR+R A ++++ + Sbjct: 738 KRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQ 797 Query: 151 L 151 L Sbjct: 798 L 798 Score = 37.0 bits (84), Expect = 0.099 Identities = 23/91 (25%), Positives = 55/91 (60%), Gaps = 5/91 (5%) Query: 47 QQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQ-AQLQEHIKELLAIKQQQELLEKEQK 105 +++ L Q+++Q +Q +F+++ + L+RQ + + +E +++ +++++ LE+EQ+ Sbjct: 1395 EEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQ 1454 Query: 106 LEQQR----QEQEVERHRREQQLPPLRGKDR 132 L Q+R +E+E RE+Q + +DR Sbjct: 1455 LRQERHRKFREEEQLLQEREEQQLHRQERDR 1485 Score = 37.0 bits (84), Expect = 0.099 Identities = 27/125 (21%), Positives = 59/125 (47%), Gaps = 15/125 (12%) Query: 43 EKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEK 102 E+QL+QE +++QQ++ Q +++ + E L + Q Q ++ ++Q ++ Sbjct: 1800 EEQLRQE----REEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQE 1855 Query: 103 EQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPT 162 + + E+Q QE E+ RR++ RER + ++++ +E + + Sbjct: 1856 KSRREEQELWQEEEQKRRQE-----------RERKLREEHIRRQQKEEQRHRQVGEIKSQ 1904 Query: 163 NGKNH 167 GK H Sbjct: 1905 EGKGH 1909 Score = 36.6 bits (83), Expect = 0.13 Identities = 27/102 (26%), Positives = 59/102 (57%), Gaps = 8/102 (7%) Query: 27 RTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEH 86 R + R+ V+ + +E++ +Q L + +++ ++QLL +E +Q E +Q + + QE Sbjct: 597 RLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSE--EQEERRQQQLRREQQER 654 Query: 87 IKELLAIKQQQELLEKEQKLE--QQRQEQEV----ERHRREQ 122 ++ L ++++E LE+ K E ++R+EQE+ + RE+ Sbjct: 655 REQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARER 696 Score = 36.6 bits (83), Expect = 0.13 Identities = 32/122 (26%), Positives = 65/122 (53%), Gaps = 8/122 (6%) Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQH-ENLTRQH--QAQLQEHIKELLAIKQQQE 98 R ++ +++ + QQ ++QLL E +K+ + RQ+ + +LQ+ ++LL +++ Sbjct: 1012 RRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETR 1071 Query: 99 LLEKEQKLEQQRQEQEVERHRREQQL--PPLRGKDRGRERAVASTEVKQKLQEFLLSKSA 156 + Q+LE+Q +++E + EQ L P + + + RER E Q+ +E LL + Sbjct: 1072 ---RRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREER 1128 Query: 157 TK 158 K Sbjct: 1129 EK 1130 Score = 36.2 bits (82), Expect = 0.17 Identities = 22/77 (28%), Positives = 47/77 (61%), Gaps = 1/77 (1%) Query: 47 QQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKL 106 ++ LL ++Q++ Q++ + Q + E R+ Q + QE +EL ++Q E E+ ++ Sbjct: 106 KESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKR-QEQERELAEGEEQSEKQERLEQR 164 Query: 107 EQQRQEQEVERHRREQQ 123 ++QR+++E+ R R+E Q Sbjct: 165 DRQRRDEELWRQRQEWQ 181 Score = 36.2 bits (82), Expect = 0.17 Identities = 32/131 (24%), Positives = 70/131 (53%), Gaps = 13/131 (9%) Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQL---QEHIKELLAIKQQQE 98 RE+Q ++E L ++Q++ ++Q L + +++ + + QL QE +E L +++++ Sbjct: 497 REQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEK 556 Query: 99 LLEKEQ-----KLEQQRQEQEV---ERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEF 150 LE+E+ K EQ+ + ++ E RR+Q+L R ++ E+ + EV++ QE Sbjct: 557 RLEQERREQRLKREQEERRDQLLKREEERRQQRLK--REQEERLEQRLKREEVERLEQEE 614 Query: 151 LLSKSATKDTP 161 + ++ P Sbjct: 615 RREQRLKREEP 625 Score = 36.2 bits (82), Expect = 0.17 Identities = 35/123 (28%), Positives = 69/123 (56%), Gaps = 14/123 (11%) Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQH-ENLTRQHQA--QLQEHIKELLAIKQQQE 98 REK+ ++E ++ QQ ++QLL E +K+ + RQ++ +LQ+ ++LL ++++ Sbjct: 986 REKKYREE----EELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKR 1041 Query: 99 LLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGR---ERAVASTEVKQKLQEFLLSKS 155 L++ ++ Q R+E+E+++ E+QL + R R ER E Q+ +E LL + Sbjct: 1042 RLQERER--QYREEEELQQ--EEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREE 1097 Query: 156 ATK 158 K Sbjct: 1098 PEK 1100 Score = 35.8 bits (81), Expect = 0.22 Identities = 24/87 (27%), Positives = 49/87 (56%), Gaps = 15/87 (17%) Query: 43 EKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEK 102 E+QL+QE +++QQ+ +Q +F+ + + + RQ Q ++ + +QQ E Sbjct: 1560 EEQLRQE----REEQQLSRQERDRKFRLEEQKVRRQEQE------RKFMEDEQQLRRQEG 1609 Query: 103 EQKLEQQ-----RQEQEVERHRREQQL 124 +Q+L Q+ R+++++ + R EQQL Sbjct: 1610 QQQLRQERDRKFREDEQLLQEREEQQL 1636 Score = 35.8 bits (81), Expect = 0.22 Identities = 28/127 (22%), Positives = 66/127 (51%), Gaps = 12/127 (9%) Query: 40 VVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQL--QEHIKELLAIKQQQ 97 ++ E+QL+ E +++QQ+++Q +F+++ + + + QL QE ++ +Q + Sbjct: 1749 ILEEEQLRPE----REEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLR 1804 Query: 98 ELLEKEQKLEQQR------QEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFL 151 + E++Q QQR +E++++ +EQ+L R + E A+ E ++ ++ L Sbjct: 1805 QEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQEL 1864 Query: 152 LSKSATK 158 + K Sbjct: 1865 WQEEEQK 1871 Score = 35.4 bits (80), Expect = 0.29 Identities = 36/126 (28%), Positives = 64/126 (50%), Gaps = 20/126 (15%) Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101 RE+Q ++E ++ QQ ++QLL E TR+ Q +L+ ++ ++Q++E L Sbjct: 1046 RERQYREE----EELQQEEEQLL------GEERETRRRQ-ELERQYRKEEELQQEEEQLL 1094 Query: 102 KEQKLEQQRQE------QEVERHRREQQLPPLRGKDRGR---ERAVASTEVKQKLQEFLL 152 +E+ +++RQE +E E + E+QL + R R ER E Q+ +E LL Sbjct: 1095 REEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLL 1154 Query: 153 SKSATK 158 + K Sbjct: 1155 REEPEK 1160 Score = 35.4 bits (80), Expect = 0.29 Identities = 25/111 (22%), Positives = 61/111 (54%), Gaps = 19/111 (17%) Query: 44 KQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQL--QEHIKELLAIKQQQELLE 101 ++ ++E ++++QQ++++ +F+++ + L + + QL QE ++ L +QQ E Sbjct: 1440 RRQERERKFLEEEQQLRQERH-RKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQE 1498 Query: 102 KEQKLEQQ------------RQEQEVERHRRE----QQLPPLRGKDRGRER 136 +++K +Q +EQ++ R +R+ Q+ LR ++RG++R Sbjct: 1499 RDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQR 1549 Score = 34.7 bits (78), Expect = 0.49 Identities = 38/128 (29%), Positives = 61/128 (47%), Gaps = 23/128 (17%) Query: 42 REKQLQQELLLIQQQQQIQKQ--LLIAEFQKQHENLTRQHQ------------AQLQE-- 85 R+K+ +QE L + ++Q +KQ L + Q++ E L RQ Q QLQ Sbjct: 138 RQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCK 197 Query: 86 -HIKELLAIKQQ---QELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVAST 141 H E ++Q +ELLE +K +++Q+Q ER R Q + R+R Sbjct: 198 GHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQ---EEEEKEWRKRETVLR 254 Query: 142 EVKQKLQE 149 + ++KLQE Sbjct: 255 KEEEKLQE 262 Score = 34.7 bits (78), Expect = 0.49 Identities = 27/103 (26%), Positives = 53/103 (51%), Gaps = 11/103 (10%) Query: 43 EKQLQQ----ELLLIQQQQQIQKQLLI-----AEFQKQHENLTRQHQAQLQEHIKELLAI 93 E+QLQ E ++Q++++ L+ +KQ + RQ + +E KE Sbjct: 190 EEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWR-- 247 Query: 94 KQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRER 136 K++ L ++E+KL+++ +++ E E+QL L ++ RER Sbjct: 248 KRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRER 290 Score = 34.7 bits (78), Expect = 0.49 Identities = 30/113 (26%), Positives = 61/113 (53%), Gaps = 10/113 (8%) Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHE----NLTRQHQAQLQEHIKELLAIKQQQ 97 R L++E + +Q+ +KQ L + +++ L + + + QE ++ L +Q++ Sbjct: 454 RRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEE 513 Query: 98 ELLEKEQKLEQQRQEQEV-ERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149 +EQ+L++Q +E+ + +R R EQQL R ++ RE+ + E K+ QE Sbjct: 514 ---RREQRLKRQEEEERLQQRLRSEQQL--RREQEERREQLLKREEEKRLEQE 561 Score = 34.7 bits (78), Expect = 0.49 Identities = 26/132 (19%), Positives = 69/132 (52%), Gaps = 7/132 (5%) Query: 19 EPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQ 78 +P LR + +++ + + RE++ ++ ++Q + ++QL E Q E ++ Sbjct: 892 KPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKR 951 Query: 79 HQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAV 138 + + + ++ ++Q++E L E+ +++RQE+E +++R E++L + E+ + Sbjct: 952 RRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQERE-KKYREEEEL------QQEEEQLL 1004 Query: 139 ASTEVKQKLQEF 150 K++ QE+ Sbjct: 1005 REEREKRRRQEW 1016 Score = 34.7 bits (78), Expect = 0.49 Identities = 27/109 (24%), Positives = 59/109 (54%), Gaps = 7/109 (6%) Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQH-ENLTRQHQAQLQEHIKELLAIKQQQELL 100 +E+Q ++E +Q QQ ++QLL E +K+ + RQ++ + KE + ++ E Sbjct: 926 QERQYREE----EQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKR 981 Query: 101 EKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149 ++++ ++ R+E+E+++ E+QL + R R+ K +LQ+ Sbjct: 982 RRQEREKKYREEEELQQ--EEEQLLREEREKRRRQEWERQYRKKDELQQ 1028 Score = 34.7 bits (78), Expect = 0.49 Identities = 29/130 (22%), Positives = 63/130 (48%), Gaps = 11/130 (8%) Query: 29 DLRMMMPVVDPVVREKQL---QQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQE 85 +LR P + E+QL Q++ +Q++QQ+++Q + ++ + R+ + QE Sbjct: 1507 ELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQE 1566 Query: 86 HIKELLAIKQQQELLE-KEQKLEQQRQE-------QEVERHRREQQLPPLRGKDRGRERA 137 ++ L+ +++ +EQK+ +Q QE Q++ R +QQL R + + Sbjct: 1567 REEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQ 1626 Query: 138 VASTEVKQKL 147 + +Q+L Sbjct: 1627 LLQEREEQQL 1636 Score = 33.9 bits (76), Expect = 0.84 Identities = 25/94 (26%), Positives = 48/94 (51%), Gaps = 8/94 (8%) Query: 52 LIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQ 111 L+Q ++Q + Q +Q E Q + Q ++ +Q++EL E E++ E+Q + Sbjct: 109 LLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQ--------EQERELAEGEEQSEKQER 160 Query: 112 EQEVERHRREQQLPPLRGKDRGRERAVASTEVKQ 145 ++ +R RR+++L R + + RE A E Q Sbjct: 161 LEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQ 194 Score = 33.9 bits (76), Expect = 0.84 Identities = 48/206 (23%), Positives = 89/206 (43%), Gaps = 31/206 (15%) Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101 RE+Q +++ L QQ ++QLL E +K+ RQ + + +EL +Q++E L Sbjct: 956 RERQYRKDKKL----QQKEEQLLGEEPEKRR----RQEREKKYREEEEL---QQEEEQLL 1004 Query: 102 KEQKLEQQRQEQEVERHRR-------EQQLPPLRGKDR--GRERAVASTEVKQKLQEFLL 152 +E++ +++RQE E + ++ EQ L R K R RER E Q+ +E LL Sbjct: 1005 REEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLL 1064 Query: 153 SKSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDD 212 G+ R +L L Q L P + + +++ Sbjct: 1065 -----------GEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREE 1113 Query: 213 FPLRKTASEPNLKVRSRLKQKVAERR 238 L++ + + R + +++ ER+ Sbjct: 1114 EELQQEEEQLLREEREKRRRQELERQ 1139 Score = 33.5 bits (75), Expect = 1.1 Identities = 27/108 (25%), Positives = 60/108 (55%), Gaps = 7/108 (6%) Query: 43 EKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEK 102 E Q ++E LL ++ ++ ++Q L +++++ E +Q + QL +E +++++ E+ Sbjct: 1145 EVQQEEEQLLREEPEKRRRQELERQYREEEE--LQQEEEQLLREEQEKRRQERERQYREE 1202 Query: 103 EQKLEQQRQEQEVERHRREQQLPPLRGK-DRGRERAVASTEVKQKLQE 149 E+ Q+R+ +R+R E Q L+ + + +E AV +V K +E Sbjct: 1203 EELQRQKRK----QRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRE 1246 Score = 32.7 bits (73), Expect = 1.9 Identities = 38/124 (30%), Positives = 62/124 (50%), Gaps = 23/124 (18%) Query: 42 REKQLQ-QELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQL-------QEHIKELLAI 93 RE +LQ QE +QQQ ++Q +Q Q E + + + +L ++ ++L A Sbjct: 742 RESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAE 801 Query: 94 KQQQ-------ELLEKEQKLEQQRQ-EQEVERHRREQQLPPLRGKDRGRERAVASTEVKQ 145 ++QQ E EKEQ+ Q+R+ E+E++ E+QL + RERA E + Sbjct: 802 ERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQL-------QRRERAQQLQEEED 854 Query: 146 KLQE 149 LQE Sbjct: 855 GLQE 858 Score = 30.8 bits (68), Expect = 7.1 Identities = 34/144 (23%), Positives = 71/144 (49%), Gaps = 21/144 (14%) Query: 42 REKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELL---------- 91 RE++L++E + +Q+++++ E +++ + L + Q Q +E IK + Sbjct: 655 REQRLKREEEEERLEQRLKRE---HEEERREQELAEEEQEQARERIKSRIPKWQWQLESE 711 Query: 92 AIKQQQELLEKEQKLEQQRQEQEV-E-RHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149 A +Q ++ + +K E QR+ QE E R RRE +L + + ERA + +++ ++ Sbjct: 712 ADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESEL-----QWQEEERAHRQQQEEEQRRD 766 Query: 150 FLLSKSATKDTPTNGKNHSVSRHP 173 F A ++ G+ +R P Sbjct: 767 FTWQWQA-EEKSERGRQRLSARPP 789 Score = 30.4 bits (67), Expect = 9.3 Identities = 28/146 (19%), Positives = 65/146 (44%), Gaps = 34/146 (23%) Query: 43 EKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQA--------------------- 81 E++LQ++ + + + Q+ L +++ + EN R ++ Sbjct: 1202 EEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDR 1261 Query: 82 QLQEHIKELLAIKQQQEL-------------LEKEQKLEQQRQEQEVERHRREQQLPPLR 128 Q Q+ ++ LL +Q+++ +E++LE++ Q++ R R+ Q+ L Sbjct: 1262 QSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLL 1321 Query: 129 GKDRGRERAVASTEVKQKLQEFLLSK 154 ++R +R T+ K + +E LL + Sbjct: 1322 REEREEKRRRQETDRKFREEEQLLQE 1347 >gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] Length = 1312 Score = 53.9 bits (128), Expect = 8e-07 Identities = 68/273 (24%), Positives = 115/273 (42%), Gaps = 43/273 (15%) Query: 43 EKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEK 102 E L++E L +QQ+ + + L KQ + L +Q Q + HIK LL +Q++ +K Sbjct: 348 ESTLRREFLRLQQENKSNSEAL-----KQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQK 402 Query: 103 EQKL---EQQRQE------QEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLS 153 E++ EQQR+E QE E+ RR + + LR ++ R +A E K+K E Sbjct: 403 EERRRVEEQQRREREQRKLQEKEQQRRLEDMQALR-REEERRQAEREQEYKRKQLE---- 457 Query: 154 KSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDF 213 + S +L A+ SL Q + LPG + + Sbjct: 458 ----------EQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHY 507 Query: 214 -----PLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVT---ESS 265 P K A ++ R+R+ ++++SPL + K G+ T + + + + Sbjct: 508 GRGMNPADKPAWAREVEERTRMN----KQQNSPLAKSKPGS--TGPEPPIPQASPGPPGP 561 Query: 266 VSSSSPGSGPSSPNNGPTGSVTENETSVLPPTP 298 +S + P P P GP S+ + T L P Sbjct: 562 LSQTPPMQRPVEPQEGPHKSLQDQPTRNLAAFP 594 Score = 34.7 bits (78), Expect = 0.49 Identities = 53/271 (19%), Positives = 109/271 (40%), Gaps = 30/271 (11%) Query: 42 REKQLQQELLLIQQQQQIQKQL----LIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQ 97 R+ + + LL Q+Q++I++Q + E Q++ + + + Q ++++ A+++++ Sbjct: 381 RDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREE 440 Query: 98 ELLE-------KEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEF 150 E + K ++LE+QRQ + ++R + +Q+ L+ + +++ + QK Q+ Sbjct: 441 ERRQAEREQEYKRKQLEEQRQSERLQR-QLQQEHAYLKSLQQQQQQ-----QQLQKQQQQ 494 Query: 151 LLSKSATKDTPTNGKNHSVSRHP--------KLWYTAAHHTSLDQSSPPLSGTSPSYKYT 202 L K G+ + + P + ++ L +S P +G P Sbjct: 495 QLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQA 554 Query: 203 LPGAQDAKDDFPLRKTASEPNLKVRSRLK-QKVAERRSSPLLRRKDGNV--VTSFKKRMF 259 PG P + EP L+ Q + P D + T+ Sbjct: 555 SPGPPGPLSQTPPMQRPVEPQEGPHKSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARG 614 Query: 260 EVTESSVSSSSPGSGPSSPNNGPTGSVTENE 290 V + +S G GPS N P +NE Sbjct: 615 AVIRQNSDPTSEGPGPSP--NPPAWVRPDNE 643 >gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo sapiens] Length = 5537 Score = 52.0 bits (123), Expect = 3e-06 Identities = 48/178 (26%), Positives = 84/178 (47%), Gaps = 18/178 (10%) Query: 39 PVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQE 98 P+ +QLQQ+ L QQQQQ+Q+Q Q+Q + + Q QLQ+ ++ +QQQ+ Sbjct: 3893 PMGSLQQLQQQQQL-QQQQQLQQQQ-----QQQLQQQQQLQQQQLQQQQQQQQLQQQQQQ 3946 Query: 99 LLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQK-----------L 147 L+++Q+ QQ+Q+Q+ ++ +++QQ + ++ R + +Q+ L Sbjct: 3947 QLQQQQQQLQQQQQQQQQQFQQQQQQQQMGLLNQSRTLLSPQQQQQQQVALGPGMPAKPL 4006 Query: 148 QEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPG 205 Q F + GK + + P + A S Q P GT+P T PG Sbjct: 4007 QHFSSPGALGPTLLLTGKEQN-TVDPAVSSEATEGPSTHQGGPLAIGTTPESMATEPG 4063 Score = 44.3 bits (103), Expect = 6e-04 Identities = 139/660 (21%), Positives = 236/660 (35%), Gaps = 137/660 (20%) Query: 43 EKQLQQELLLIQQQQQIQKQL-LIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLE 101 E ++ L+ +QQ +IQKQL + + QK+H NL +++ KQQQ+ Sbjct: 3558 EADAEKLKLVTEQQSKIQKQLDQVRKQQKEHTNLMAEYRN------------KQQQQ--- 3602 Query: 102 KEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTP 161 +Q+ +QQ+Q+ Q P L K G+ + Q + TP Sbjct: 3603 -QQQQQQQQQQHSAVLALSPSQSPRLLTKLPGQLLPGHGLQPPQGPPGG--QAGGLRLTP 3659 Query: 162 TNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASE 221 P L A S S PS + PG + P + E Sbjct: 3660 GGMALPGQPGGPFLNTALAQQQQQQHSGGAGSLAGPSGGF-FPGNLALRSLGPDSRLLQE 3718 Query: 222 PNLKV---RSRLKQKVAERRSSPLLRRKD-GNVVTSFKKRMFEVTESSVSSSSPGSG--- 274 L++ R +L QK+ +++ ++ G V +++ +++ + G Sbjct: 3719 RQLQLQQQRMQLAQKLQQQQQQQQQQQHLLGQVAIQQQQQQGPGVQTNQALGPKPQGLMP 3778 Query: 275 PSS------------PNNGPTGSVTENETSVL---------PPTPHAEQMVSQQRILIHE 313 PSS P GP G + + +VL P PH + +++Q R+L Sbjct: 3779 PSSHQGLLVQQLSPQPPQGPQGMLGPAQVAVLQQQHPGALGPQGPHRQVLMTQSRVL--- 3835 Query: 314 DSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQYGGSIP 373 +SP L GL + +L + +++Q+ + Q G+ Q S+ Sbjct: 3836 ---------SSPQLAQQGQGL--MGHRLVTAQQQQQQQQHQQQGSMAGLSHLQQ---SLM 3881 Query: 374 ASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPG 433 + S P L +P S Q Q L ++Q QQ+ Q L ++++ Sbjct: 3882 SHSGQPK--LSAQPMGSLQQLQQQQQLQQQQQLQQQ----------QQQQLQQQQQL--- 3926 Query: 434 IRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIE 493 Q L Q Q + QQQ QQ ++Q+Q QQQ + + + Sbjct: 3927 ----------------QQQQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQQQQQQQFQQQQ 3970 Query: 494 QLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRS----DSSACVDDTLGQVGAVKVKE 549 Q +Q G L ++ L Q Q+ A G + S + TL G + Sbjct: 3971 QQQQMGL-LNQSRTLLSPQQQQQQQVALGPGMPAKPLQHFSSPGALGPTLLLTGKEQNTV 4029 Query: 550 EPVDSD-------------------------EDAQIQEMESGEQAAFMQQPFLEPTHT-- 582 +P S E +++ SG+ + QP +P + Sbjct: 4030 DPAVSSEATEGPSTHQGGPLAIGTTPESMATEPGEVKPSLSGDSQLLLVQPQPQPQPSSL 4089 Query: 583 ------RALSVRQAPLAAVGMDGLEKHRLVSRTHSSPAASV---LPHPAMDRPLQPGSAT 633 R +Q ++ + G H + SS A+SV L P++ QPGS T Sbjct: 4090 QLQPPLRLPGQQQQQVSLLHTAGGGSHGQLGSGSSSEASSVPHLLAQPSVSLGDQPGSMT 4149 >gi|114155142 nuclear pore complex-associated protein TPR [Homo sapiens] Length = 2363 Score = 52.0 bits (123), Expect = 3e-06 Identities = 104/548 (18%), Positives = 217/548 (39%), Gaps = 68/548 (12%) Query: 43 EKQLQQELLLIQQQQQIQKQL--LIAEFQKQHENLTRQHQAQLQ-------EHIKELLAI 93 +K L +++ IQ++ + Q+ + ++ Q+E L Q ++ +H ++ +++ Sbjct: 1414 QKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSV 1473 Query: 94 KQQQELLE-------KEQKLEQQRQ-------EQEVERHRREQQLPPLRGK-DRGRERAV 138 ++ QEL E K + LE Q + E+E E ++Q L+ + R R+ Sbjct: 1474 QEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQ 1533 Query: 139 ASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPS 198 T +++L++ + K + V+ K+ + A L + + L + Sbjct: 1534 DRTTQEEQLRQQITEKEEKT------RKAIVAAKSKIAHLAGVKDQLTKENEELKQRN-- 1585 Query: 199 YKYTLPGAQDA-KDDFPLRKTASEPNLKVR-SRLKQKVAERRSSPLLRRKDGNVVTSFKK 256 GA D KD+ +R TA + + R SRL++++ E + L +R + ++ Sbjct: 1586 ------GALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVP 1639 Query: 257 RMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSM 316 + +S G +S ++ PT ++ P A M + Sbjct: 1640 EQQRQITLKTTPASGERGIASTSDPPTANIKPTPVVSTPSKVTAAAMAGNKST----PRA 1695 Query: 317 NLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQYGGSIPASS 376 ++ + T ++ N T A + + ++ ++ +++ + VP+ G GS+ ++S Sbjct: 1696 SIRPMVTPATVTNPTTTPTAT---VMPTTQVESQEAMQSEGPVEHVPVFGSTSGSVRSTS 1752 Query: 377 SHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRG 436 P+V ++ Q +L +Q Q V HPQ A +E S + Sbjct: 1753 --PNV----------QPSISQPILTVQQQTQATAFVQPTQQSHPQIEPANQELSSNIVEV 1800 Query: 437 THKLPRHRPLNRT----QSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSI 492 P RP T + P S+L + +++ +E Q + L K + Sbjct: 1801 VQSSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEASDQVSDDT-VEMPLPKKL 1859 Query: 493 EQLKQPGSHLE-EAEEELQGD---QAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVK 548 + + G+ E AEE G+ Q +D S G ++D+ ++++ Sbjct: 1860 KSVTPVGTEEEVMAEESTDGEVETQVYNQDSQDSIGEGVTQGDYTPMEDSEETSQSLQID 1919 Query: 549 EEPVDSDE 556 P+ SD+ Sbjct: 1920 LGPLQSDQ 1927 Score = 31.2 bits (69), Expect = 5.4 Identities = 25/113 (22%), Positives = 57/113 (50%), Gaps = 6/113 (5%) Query: 41 VREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKEL----LAIKQQ 96 V + +Q + L++++ Q + L AE +K +T + AQ +E +K+ + ++ Sbjct: 1219 VESLRYRQRVELLERELQELQDSLNAEREKVQ--VTAKTMAQHEELMKKTETMNVVMETN 1276 Query: 97 QELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQE 149 + L E++++LEQ Q+ + + + E + PL+ + + ++KL E Sbjct: 1277 KMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLE 1329 >gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4 isoform 1 [Homo sapiens] Length = 1166 Score = 52.0 bits (123), Expect = 3e-06 Identities = 62/246 (25%), Positives = 107/246 (43%), Gaps = 29/246 (11%) Query: 53 IQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQ-RQ 111 +++QQ +Q+Q L ++ E RQ A+ Q+ I++ K+Q+ LE++Q+ E++ R+ Sbjct: 370 LRRQQLLQEQQL-----REQEEYKRQLLAERQKRIEQQ---KEQRRRLEEQQRREREARR 421 Query: 112 EQEVERHRREQ-------QLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNG 164 +QE E+ RREQ +L R ++ R RA ++ QE++ + + Sbjct: 422 QQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEV 481 Query: 165 KNHSVSRHPKLW---YTAAHHTSLDQSSPPLSGTS-PSYKYTLPGAQ----DAKDDFPLR 216 + + + + H Q PP S PS+ P A D + P+R Sbjct: 482 LQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVPVR 541 Query: 217 KTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKR-MFEVTESSVSSSSPGSGP 275 T+ P L R Q ++ S R N +S + R ++E E V GS Sbjct: 542 TTSRSPVLSRRDSPLQGSGQQNSQAGQR----NSTSSIEPRLLWERVEKLVPRPGSGSSS 597 Query: 276 SSPNNG 281 S N+G Sbjct: 598 GSSNSG 603 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.313 0.129 0.369 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 44,427,342 Number of Sequences: 37866 Number of extensions: 2248208 Number of successful extensions: 20215 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 243 Number of HSP's successfully gapped in prelim test: 634 Number of HSP's that attempted gapping in prelim test: 10627 Number of HSP's gapped (non-prelim): 5408 length of query: 1066 length of database: 18,247,518 effective HSP length: 113 effective length of query: 953 effective length of database: 13,968,660 effective search space: 13312132980 effective search space used: 13312132980 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.9 bits) S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.