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Search of human proteins with 30520335
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|30520335 WD repeat domain 49 [Homo sapiens]
(697 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|30520335 WD repeat domain 49 [Homo sapiens] 1428 0.0
gi|221139921 EF-hand calcium binding domain 8 [Homo sapiens] 145 9e-35
gi|115495443 WD repeat domain 64 [Homo sapiens] 108 1e-23
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 66 1e-10
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 66 1e-10
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 66 1e-10
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 65 2e-10
gi|23199987 WD repeat domain 5B [Homo sapiens] 64 6e-10
gi|21071067 TBP-associated factor 5 [Homo sapiens] 60 7e-09
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 60 9e-09
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 59 1e-08
gi|32189425 WD repeat domain 69 [Homo sapiens] 55 2e-07
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 54 4e-07
gi|113865883 WD repeat domain 38 [Homo sapiens] 54 6e-07
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 53 1e-06
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [... 52 1e-06
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H... 52 2e-06
gi|16554629 WD repeat domain 5 [Homo sapiens] 52 2e-06
gi|16554627 WD repeat domain 5 [Homo sapiens] 52 2e-06
gi|18874090 WD repeat domain 48 [Homo sapiens] 51 4e-06
gi|53729352 WD repeat-containing protein 1 isoform 2 [Homo sapiens] 51 4e-06
gi|9257257 WD repeat-containing protein 1 isoform 1 [Homo sapiens] 51 4e-06
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ... 51 4e-06
gi|142976686 nuclear autoantigen isoform 1 [Homo sapiens] 50 5e-06
gi|142976675 nuclear autoantigen isoform 2 [Homo sapiens] 50 5e-06
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [... 50 7e-06
gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 50 7e-06
gi|4759276 RNA, U3 small nucleolar interacting protein 2 [Homo s... 49 1e-05
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 49 2e-05
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 49 2e-05
>gi|30520335 WD repeat domain 49 [Homo sapiens]
Length = 697
Score = 1428 bits (3697), Expect = 0.0
Identities = 697/697 (100%), Positives = 697/697 (100%)
Query: 1 MAWREKSKKRLNMTSFNIAQGIHAFDYHSRLNLIATAGINNKVCLWNPYVVSKPVGVLWG 60
MAWREKSKKRLNMTSFNIAQGIHAFDYHSRLNLIATAGINNKVCLWNPYVVSKPVGVLWG
Sbjct: 1 MAWREKSKKRLNMTSFNIAQGIHAFDYHSRLNLIATAGINNKVCLWNPYVVSKPVGVLWG 60
Query: 61 HSASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRIACSFPKSQDFRCLFHFDEAH 120
HSASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRIACSFPKSQDFRCLFHFDEAH
Sbjct: 61 HSASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRIACSFPKSQDFRCLFHFDEAH 120
Query: 121 GRLFISFNNQLALLAMKSEASKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTG 180
GRLFISFNNQLALLAMKSEASKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTG
Sbjct: 121 GRLFISFNNQLALLAMKSEASKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTG 180
Query: 181 QKIKQFTGCHGNAEISTMALDANETRLLTGSTDGTVKIWDFNGYCHHTLNVGQDGAVDIS 240
QKIKQFTGCHGNAEISTMALDANETRLLTGSTDGTVKIWDFNGYCHHTLNVGQDGAVDIS
Sbjct: 181 QKIKQFTGCHGNAEISTMALDANETRLLTGSTDGTVKIWDFNGYCHHTLNVGQDGAVDIS 240
Query: 241 QILILKKKILVTGWERAITVFRPQNFNQFFIQPEEWKGGIQHHDDILCAAFLPPQTLVTG 300
QILILKKKILVTGWERAITVFRPQNFNQFFIQPEEWKGGIQHHDDILCAAFLPPQTLVTG
Sbjct: 241 QILILKKKILVTGWERAITVFRPQNFNQFFIQPEEWKGGIQHHDDILCAAFLPPQTLVTG 300
Query: 301 SYDGEIVLWNNSTENAHHVLHPDYQRLLKSKLDTKPQKLLSAGRSQPSHPMADHSTTGVR 360
SYDGEIVLWNNSTENAHHVLHPDYQRLLKSKLDTKPQKLLSAGRSQPSHPMADHSTTGVR
Sbjct: 301 SYDGEIVLWNNSTENAHHVLHPDYQRLLKSKLDTKPQKLLSAGRSQPSHPMADHSTTGVR 360
Query: 361 NFEIDTEGKNAVMRLCFLKARKNTAVTGGANLVSCGGSGYVRFWDIYKKQLLAEFLAHSG 420
NFEIDTEGKNAVMRLCFLKARKNTAVTGGANLVSCGGSGYVRFWDIYKKQLLAEFLAHSG
Sbjct: 361 NFEIDTEGKNAVMRLCFLKARKNTAVTGGANLVSCGGSGYVRFWDIYKKQLLAEFLAHSG 420
Query: 421 VGSIIMSTDKMNRYLTTGDLDGWLKIWNIEEYCLNSSKNKITKAPTLIRSFQPHEDRISS 480
VGSIIMSTDKMNRYLTTGDLDGWLKIWNIEEYCLNSSKNKITKAPTLIRSFQPHEDRISS
Sbjct: 421 VGSIIMSTDKMNRYLTTGDLDGWLKIWNIEEYCLNSSKNKITKAPTLIRSFQPHEDRISS 480
Query: 481 LEMCEPGGQLLIISSSADCSICVTGVCNAPVWIFGQAKHWHIENCLFLPKRDTNLVESEI 540
LEMCEPGGQLLIISSSADCSICVTGVCNAPVWIFGQAKHWHIENCLFLPKRDTNLVESEI
Sbjct: 481 LEMCEPGGQLLIISSSADCSICVTGVCNAPVWIFGQAKHWHIENCLFLPKRDTNLVESEI 540
Query: 541 QKEISLFSKEESCLDPTEHSLLNKKNKDDSTYNVRPSEDINLDIKYKERSTCMKETQKPY 600
QKEISLFSKEESCLDPTEHSLLNKKNKDDSTYNVRPSEDINLDIKYKERSTCMKETQKPY
Sbjct: 541 QKEISLFSKEESCLDPTEHSLLNKKNKDDSTYNVRPSEDINLDIKYKERSTCMKETQKPY 600
Query: 601 YGEVIKKSFSTFRSLNIGALEELPEVNKPAFLLDPEKYFRKEPEEERPQILEAPSLFKTL 660
YGEVIKKSFSTFRSLNIGALEELPEVNKPAFLLDPEKYFRKEPEEERPQILEAPSLFKTL
Sbjct: 601 YGEVIKKSFSTFRSLNIGALEELPEVNKPAFLLDPEKYFRKEPEEERPQILEAPSLFKTL 660
Query: 661 KAVFDEKNLFPKEILHHERKAKQLCQEKSCEVKKNKK 697
KAVFDEKNLFPKEILHHERKAKQLCQEKSCEVKKNKK
Sbjct: 661 KAVFDEKNLFPKEILHHERKAKQLCQEKSCEVKKNKK 697
>gi|221139921 EF-hand calcium binding domain 8 [Homo sapiens]
Length = 1288
Score = 145 bits (367), Expect = 9e-35
Identities = 102/318 (32%), Positives = 153/318 (48%), Gaps = 17/318 (5%)
Query: 6 KSKKRLNMTSFNIAQGIHAFDYHSRLNLIATAGINNKVCLWNPYVVSKPVGVLWGHSASV 65
K+ K+ ++ + +GI FDY N + T G + + LWNP+V +PV ++ GH SV
Sbjct: 357 KASKKPRLSVLRLRKGILCFDYCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSV 416
Query: 66 IAVQFFVERKQ---LFSFSKDKVLRLWDIQHQLSIQRIACSFPKSQDFRCLFHFDEAHGR 122
V+ + L S SKDK +R+WD+ + +Q F + +
Sbjct: 417 --THILVDSRNNSILISVSKDKNIRVWDMLDYICLQSFCGKFFALGNCPITSAYFFEKDN 474
Query: 123 LFISFNNQLALLAMKSEASKRVKSHEKAVTC-----VLYNSILKQVISSDTGSTVSFWMI 177
I + +L EA +K+ ++ C VLY+ I KQV+S TVS W +
Sbjct: 475 TLICSTYSIGILKGYLEAQGLIKARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEV 534
Query: 178 DTGQKIKQFTGCHG-NAEISTMALDANETRLLTGSTDGTVKIWDFN-GYCHHTLNVGQDG 235
TG+K +F G + E++ MALD +E LLTG DGT+K+W++N G C L
Sbjct: 535 VTGRKTMEFAVSGGQHVEMTAMALDESERCLLTGLRDGTMKMWNYNIGKC--LLTFPSPE 592
Query: 236 AVDISQILILKKKILVTGWERAITVFRPQNFNQFFIQPEEWKGGIQHHDDILCAAFLPPQ 295
++IS I+ + K VTGW + IT F + W+ H +DIL A Q
Sbjct: 593 QLEISGIIHMNKVFYVTGWSKRITHFLFHKTKPVLL-CYHWQ--TYHTEDILSMAKYRNQ 649
Query: 296 TLVTGSYDGEIVLWNNST 313
L T SY G+I+ WN T
Sbjct: 650 FLGTSSYSGDILFWNTGT 667
Score = 50.1 bits (118), Expect = 7e-06
Identities = 30/87 (34%), Positives = 49/87 (56%), Gaps = 6/87 (6%)
Query: 371 AVMRLCFLKARKNTAVTGGANLVSCGGSGYVRFWDIYKKQ-LLAEFLAHSGVGSII---M 426
+V ++ FL+ R T A L+S GY+ W +++ LL +F G ++ M
Sbjct: 801 SVEKIIFLQTRPRLPHT--AALLSSCMDGYIYAWSLHENGGLLGKFPVDLDNGDVVVGAM 858
Query: 427 STDKMNRYLTTGDLDGWLKIWNIEEYC 453
+TDK + L TGD G++KIW+I++YC
Sbjct: 859 ATDKNDWILITGDCKGYIKIWDIKDYC 885
Score = 38.5 bits (88), Expect = 0.021
Identities = 15/36 (41%), Positives = 21/36 (58%)
Query: 190 HGNAEISTMALDANETRLLTGSTDGTVKIWDFNGYC 225
+G+ + MA D N+ L+TG G +KIWD YC
Sbjct: 850 NGDVVVGAMATDKNDWILITGDCKGYIKIWDIKDYC 885
>gi|115495443 WD repeat domain 64 [Homo sapiens]
Length = 634
Score = 108 bits (271), Expect = 1e-23
Identities = 73/250 (29%), Positives = 126/250 (50%), Gaps = 8/250 (3%)
Query: 5 EKSKKRLNMTSFNIAQGIHAFDYHSRLNLIATAGINNKVCLWNPYVVSKPVGVLWGHSAS 64
++ + L + F++ +G + F Y + N+I T G + + LW+P + +KPVG L GH S
Sbjct: 29 KRLEDNLPVREFSMPRGANTFCYCVKANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFS 88
Query: 65 VIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRIACSFPKSQDFRCL-FHFDEAHGRL 123
+ + + + + S S KV R+WDIQ +Q S D + +D HG L
Sbjct: 89 IAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGML 148
Query: 124 FI--SFNNQLALLAMKSEASKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQ 181
S + L M + + +HE+ + +LYN QV++ + S + W ++TG
Sbjct: 149 ITGSSVMDMYPLTRMIQDTKQVPHTHEREINVMLYNKYFHQVLTICSESIIRVWELETGL 208
Query: 182 KIKQFTGCHG-NAEISTMALDANETRLLTGSTDGTVKIWDF-NGYCHHTLNVGQDGAVD- 238
++ Q HG N E+++ A+D + TG+ +GTV+IWDF +G L G+D D
Sbjct: 209 QVYQILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDWKEDE 268
Query: 239 --ISQILILK 246
+ +++ LK
Sbjct: 269 HCLRRLIFLK 278
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 66.2 bits (160), Expect = 1e-10
Identities = 67/319 (21%), Positives = 128/319 (40%), Gaps = 44/319 (13%)
Query: 139 EASKRVKSHEK-AVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGNAEIST 197
++ K +K H+ +TC+ + +++S +T+ W TG+ ++ G G S
Sbjct: 253 KSPKVLKGHDDHVITCLQFCG--NRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQ 310
Query: 198 MALDANETRLLTGSTDGTVKIWDFN-GYCHHTLNVGQDGAVDISQILILKKKILVTGWER 256
M + +++GSTD T+K+W+ G C HTL G + + L +K +V+G
Sbjct: 311 M----RDNIIISGSTDRTLKVWNAETGECIHTLY----GHTSTVRCMHLHEKRVVSG--- 359
Query: 257 AITVFRPQNFNQFFIQPEEWKGGIQHHDDILCAAFLPPQTLVTGSYDGEIVLWNNSTENA 316
R + I+ + + H + + +V+G+YD + +W+ TE
Sbjct: 360 ----SRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETC 415
Query: 317 HHVLHPDYQRLLKSKLDTKPQKLLSAGRSQPSHPMADHSTTGVRNFEIDTEGKNAVMRLC 376
H L R+ + D H ++ T +R ++++T C
Sbjct: 416 LHTLQGHTNRVYSLQFDG-------------IHVVSGSLDTSIRVWDVETGN-------C 455
Query: 377 FLKARKNTAVTGGANL-----VSCGGSGYVRFWDIYKKQLLAEFLAHSGVGSIIMSTDKM 431
+ ++T G L VS V+ WDI Q L + S +
Sbjct: 456 IHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFN 515
Query: 432 NRYLTTGDLDGWLKIWNIE 450
++ T DG +K+W+++
Sbjct: 516 KNFVITSSDDGTVKLWDLK 534
Score = 57.8 bits (138), Expect = 3e-08
Identities = 50/204 (24%), Positives = 92/204 (45%), Gaps = 20/204 (9%)
Query: 30 RLNLIATAGINNKVCLWNPYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLW 89
R N+I + + + +WN + + L+GH+++V + + K++ S S+D LR+W
Sbjct: 312 RDNIIISGSTDRTLKVWNAET-GECIHTLYGHTSTVRCMH--LHEKRVVSGSRDATLRVW 368
Query: 90 DIQHQLSIQRIACSFPKSQDFRCLFHFDEAHGRLFISFNNQLALLAMKSEASK---RVKS 146
DI+ + Q + RC+ + GR +S + E ++
Sbjct: 369 DIE---TGQCLHVLMGHVAAVRCV----QYDGRRVVSGAYDFMVKVWDPETETCLHTLQG 421
Query: 147 HEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGNAEISTMALDANETR 206
H V + ++ I V+S +++ W ++TG I TG + T ++ +
Sbjct: 422 HTNRVYSLQFDGI--HVVSGSLDTSIRVWDVETGNCIHTLTG----HQSLTSGMELKDNI 475
Query: 207 LLTGSTDGTVKIWDF-NGYCHHTL 229
L++G+ D TVKIWD G C TL
Sbjct: 476 LVSGNADSTVKIWDIKTGQCLQTL 499
Score = 38.9 bits (89), Expect = 0.016
Identities = 43/182 (23%), Positives = 79/182 (43%), Gaps = 21/182 (11%)
Query: 43 VCLWNPYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRIAC 102
V +W+P + + L GH+ V ++QF + + S S D +R+WD++ I +
Sbjct: 405 VKVWDPETETC-LHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLT- 460
Query: 103 SFPKSQDFRCLFHFDEAHGRLFISFNNQLALLAMKSEASKRVKS------HEKAVTCVLY 156
+ L E + +S N + + + +++ H+ AVTC+ +
Sbjct: 461 ------GHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQF 514
Query: 157 NSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCH-GNAEISTMALDANETRLL--TGSTD 213
N VI+S TV W + TG+ I+ G + + A+ T+L+ GS +
Sbjct: 515 NKNF--VITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRN 572
Query: 214 GT 215
GT
Sbjct: 573 GT 574
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 66.2 bits (160), Expect = 1e-10
Identities = 67/319 (21%), Positives = 128/319 (40%), Gaps = 44/319 (13%)
Query: 139 EASKRVKSHEK-AVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGNAEIST 197
++ K +K H+ +TC+ + +++S +T+ W TG+ ++ G G S
Sbjct: 371 KSPKVLKGHDDHVITCLQFCG--NRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQ 428
Query: 198 MALDANETRLLTGSTDGTVKIWDFN-GYCHHTLNVGQDGAVDISQILILKKKILVTGWER 256
M + +++GSTD T+K+W+ G C HTL G + + L +K +V+G
Sbjct: 429 M----RDNIIISGSTDRTLKVWNAETGECIHTLY----GHTSTVRCMHLHEKRVVSG--- 477
Query: 257 AITVFRPQNFNQFFIQPEEWKGGIQHHDDILCAAFLPPQTLVTGSYDGEIVLWNNSTENA 316
R + I+ + + H + + +V+G+YD + +W+ TE
Sbjct: 478 ----SRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETC 533
Query: 317 HHVLHPDYQRLLKSKLDTKPQKLLSAGRSQPSHPMADHSTTGVRNFEIDTEGKNAVMRLC 376
H L R+ + D H ++ T +R ++++T C
Sbjct: 534 LHTLQGHTNRVYSLQFDG-------------IHVVSGSLDTSIRVWDVETGN-------C 573
Query: 377 FLKARKNTAVTGGANL-----VSCGGSGYVRFWDIYKKQLLAEFLAHSGVGSIIMSTDKM 431
+ ++T G L VS V+ WDI Q L + S +
Sbjct: 574 IHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFN 633
Query: 432 NRYLTTGDLDGWLKIWNIE 450
++ T DG +K+W+++
Sbjct: 634 KNFVITSSDDGTVKLWDLK 652
Score = 57.8 bits (138), Expect = 3e-08
Identities = 50/204 (24%), Positives = 92/204 (45%), Gaps = 20/204 (9%)
Query: 30 RLNLIATAGINNKVCLWNPYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLW 89
R N+I + + + +WN + + L+GH+++V + + K++ S S+D LR+W
Sbjct: 430 RDNIIISGSTDRTLKVWNAET-GECIHTLYGHTSTVRCMH--LHEKRVVSGSRDATLRVW 486
Query: 90 DIQHQLSIQRIACSFPKSQDFRCLFHFDEAHGRLFISFNNQLALLAMKSEASK---RVKS 146
DI+ + Q + RC+ + GR +S + E ++
Sbjct: 487 DIE---TGQCLHVLMGHVAAVRCV----QYDGRRVVSGAYDFMVKVWDPETETCLHTLQG 539
Query: 147 HEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGNAEISTMALDANETR 206
H V + ++ I V+S +++ W ++TG I TG + T ++ +
Sbjct: 540 HTNRVYSLQFDGI--HVVSGSLDTSIRVWDVETGNCIHTLTG----HQSLTSGMELKDNI 593
Query: 207 LLTGSTDGTVKIWDF-NGYCHHTL 229
L++G+ D TVKIWD G C TL
Sbjct: 594 LVSGNADSTVKIWDIKTGQCLQTL 617
Score = 38.9 bits (89), Expect = 0.016
Identities = 43/182 (23%), Positives = 79/182 (43%), Gaps = 21/182 (11%)
Query: 43 VCLWNPYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRIAC 102
V +W+P + + L GH+ V ++QF + + S S D +R+WD++ I +
Sbjct: 523 VKVWDPETETC-LHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLT- 578
Query: 103 SFPKSQDFRCLFHFDEAHGRLFISFNNQLALLAMKSEASKRVKS------HEKAVTCVLY 156
+ L E + +S N + + + +++ H+ AVTC+ +
Sbjct: 579 ------GHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQF 632
Query: 157 NSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCH-GNAEISTMALDANETRLL--TGSTD 213
N VI+S TV W + TG+ I+ G + + A+ T+L+ GS +
Sbjct: 633 NKNF--VITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRN 690
Query: 214 GT 215
GT
Sbjct: 691 GT 692
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 66.2 bits (160), Expect = 1e-10
Identities = 67/319 (21%), Positives = 128/319 (40%), Gaps = 44/319 (13%)
Query: 139 EASKRVKSHEK-AVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGNAEIST 197
++ K +K H+ +TC+ + +++S +T+ W TG+ ++ G G S
Sbjct: 291 KSPKVLKGHDDHVITCLQFCG--NRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQ 348
Query: 198 MALDANETRLLTGSTDGTVKIWDFN-GYCHHTLNVGQDGAVDISQILILKKKILVTGWER 256
M + +++GSTD T+K+W+ G C HTL G + + L +K +V+G
Sbjct: 349 M----RDNIIISGSTDRTLKVWNAETGECIHTLY----GHTSTVRCMHLHEKRVVSG--- 397
Query: 257 AITVFRPQNFNQFFIQPEEWKGGIQHHDDILCAAFLPPQTLVTGSYDGEIVLWNNSTENA 316
R + I+ + + H + + +V+G+YD + +W+ TE
Sbjct: 398 ----SRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETC 453
Query: 317 HHVLHPDYQRLLKSKLDTKPQKLLSAGRSQPSHPMADHSTTGVRNFEIDTEGKNAVMRLC 376
H L R+ + D H ++ T +R ++++T C
Sbjct: 454 LHTLQGHTNRVYSLQFDG-------------IHVVSGSLDTSIRVWDVETGN-------C 493
Query: 377 FLKARKNTAVTGGANL-----VSCGGSGYVRFWDIYKKQLLAEFLAHSGVGSIIMSTDKM 431
+ ++T G L VS V+ WDI Q L + S +
Sbjct: 494 IHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFN 553
Query: 432 NRYLTTGDLDGWLKIWNIE 450
++ T DG +K+W+++
Sbjct: 554 KNFVITSSDDGTVKLWDLK 572
Score = 57.8 bits (138), Expect = 3e-08
Identities = 50/204 (24%), Positives = 92/204 (45%), Gaps = 20/204 (9%)
Query: 30 RLNLIATAGINNKVCLWNPYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLW 89
R N+I + + + +WN + + L+GH+++V + + K++ S S+D LR+W
Sbjct: 350 RDNIIISGSTDRTLKVWNAET-GECIHTLYGHTSTVRCMH--LHEKRVVSGSRDATLRVW 406
Query: 90 DIQHQLSIQRIACSFPKSQDFRCLFHFDEAHGRLFISFNNQLALLAMKSEASK---RVKS 146
DI+ + Q + RC+ + GR +S + E ++
Sbjct: 407 DIE---TGQCLHVLMGHVAAVRCV----QYDGRRVVSGAYDFMVKVWDPETETCLHTLQG 459
Query: 147 HEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGNAEISTMALDANETR 206
H V + ++ I V+S +++ W ++TG I TG + T ++ +
Sbjct: 460 HTNRVYSLQFDGI--HVVSGSLDTSIRVWDVETGNCIHTLTG----HQSLTSGMELKDNI 513
Query: 207 LLTGSTDGTVKIWDF-NGYCHHTL 229
L++G+ D TVKIWD G C TL
Sbjct: 514 LVSGNADSTVKIWDIKTGQCLQTL 537
Score = 38.9 bits (89), Expect = 0.016
Identities = 43/182 (23%), Positives = 79/182 (43%), Gaps = 21/182 (11%)
Query: 43 VCLWNPYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRIAC 102
V +W+P + + L GH+ V ++QF + + S S D +R+WD++ I +
Sbjct: 443 VKVWDPETETC-LHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLT- 498
Query: 103 SFPKSQDFRCLFHFDEAHGRLFISFNNQLALLAMKSEASKRVKS------HEKAVTCVLY 156
+ L E + +S N + + + +++ H+ AVTC+ +
Sbjct: 499 ------GHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQF 552
Query: 157 NSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCH-GNAEISTMALDANETRLL--TGSTD 213
N VI+S TV W + TG+ I+ G + + A+ T+L+ GS +
Sbjct: 553 NKNF--VITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRN 610
Query: 214 GT 215
GT
Sbjct: 611 GT 612
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 65.5 bits (158), Expect = 2e-10
Identities = 50/205 (24%), Positives = 96/205 (46%), Gaps = 16/205 (7%)
Query: 22 IHAFDYHSRLNLIATAGINNKVCLWNPYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFS 81
++ +H + +A+AG + + LWN Y L GHS +V+ + + + LFS S
Sbjct: 69 VYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSAS 128
Query: 82 KDKVLRLWDIQHQLSIQRIA--CSFPKSQDFRCLFHFDEAHGRLFI---SFNNQLALLAM 136
DK + +WD + ++R+ SF S C + G + S + + L +
Sbjct: 129 TDKTVAVWDSETGERVKRLKGHTSFVNS----C---YPARRGPQLVCTGSDDGTVKLWDI 181
Query: 137 KSEASKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGNAE-I 195
+ +A+ + + V V +N Q+IS + + W D Q +T G+A+ +
Sbjct: 182 RKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVW--DLRQNKLTYT-MRGHADSV 238
Query: 196 STMALDANETRLLTGSTDGTVKIWD 220
+ ++L + + LL+ + D TV++WD
Sbjct: 239 TGLSLSSEGSYLLSNAMDNTVRVWD 263
Score = 47.4 bits (111), Expect = 5e-05
Identities = 40/167 (23%), Positives = 63/167 (37%), Gaps = 44/167 (26%)
Query: 54 PVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRIACSFPKSQDFRCL 113
P+ +L GH V +F L S D+++ LW++
Sbjct: 58 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNV---------------------- 95
Query: 114 FHFDEAHGRLFISFNNQLALLAMKSEASKRVKSHEKAVTCVLYNSILKQVISSDTGSTVS 173
+ +N L K H AV + YN+ + S+ T TV+
Sbjct: 96 ----------YGDCDNYATL-----------KGHSGAVMELHYNTDGSMLFSASTDKTVA 134
Query: 174 FWMIDTGQKIKQFTGCHGNAEISTMALDANETRLLTGSTDGTVKIWD 220
W +TG+++K+ G H + S + TGS DGTVK+WD
Sbjct: 135 VWDSETGERVKRLKG-HTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180
Score = 35.8 bits (81), Expect = 0.14
Identities = 20/85 (23%), Positives = 42/85 (49%), Gaps = 1/85 (1%)
Query: 8 KKRLNMTSFNIAQGIHAFDYHSRLNLIATAGINNKVCLWNPYVVSKPVGVLWGHSASVIA 67
+K+ + +F + A ++ + I + GI+N + +W+ +K + GH+ SV
Sbjct: 182 RKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWD-LRQNKLTYTMRGHADSVTG 240
Query: 68 VQFFVERKQLFSFSKDKVLRLWDIQ 92
+ E L S + D +R+WD++
Sbjct: 241 LSLSSEGSYLLSNAMDNTVRVWDVR 265
Score = 29.6 bits (65), Expect = 9.9
Identities = 18/50 (36%), Positives = 25/50 (50%), Gaps = 1/50 (2%)
Query: 294 PQTLVTGSYDGEIVLWNNSTENAHHVLHPDYQRLLKSKLDTKPQKLLSAG 343
PQ + TGS DG + LW+ + A YQ L + DT Q ++S G
Sbjct: 164 PQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQ-IISGG 212
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 63.5 bits (153), Expect = 6e-10
Identities = 69/314 (21%), Positives = 131/314 (41%), Gaps = 23/314 (7%)
Query: 5 EKSKKRLNMTSFNIAQGIHAFDYHSRLNLIATAGINNKVCLWNPYVVSKPVGVLWGHSAS 64
E L T + + + + +A++ + + +W Y K L+GH+
Sbjct: 27 ENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYD-GKYEKTLYGHNLE 85
Query: 65 VIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRIACSFPKSQDFRCLFHFDEAHGRLF 124
+ V + + +L S S DK L+LWD++ ++ + + F C F+ L
Sbjct: 86 ISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTL--KGHSNYVFCCNFN---PPSNLI 140
Query: 125 I--SFNNQLALLAMKS-EASKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQ 181
I SF+ + + +K+ + K + +H V+ V +N ++S W +GQ
Sbjct: 141 ISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQ 200
Query: 182 KIKQFTGCHGNAEISTMALDANETRLLTGSTDGTVKIWDFN-GYCHHTLNVGQDGAVDI- 239
+K N +S + N +LT + D T+K+WD++ G C T ++ I
Sbjct: 201 CLKTLVD-DDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIF 259
Query: 240 SQILILKKKILVTGWERAITVFRPQNFNQFFIQPEEWKGGIQHHDD-ILCAAFLPPQTLV 298
+ + K +V+G E + + +Q +E +Q H D ++ AA P + L+
Sbjct: 260 ANFSVTGGKWIVSGSEDNLVYI-------WNLQTKEIVQKLQGHTDVVISAACHPTENLI 312
Query: 299 TGS---YDGEIVLW 309
+ D I LW
Sbjct: 313 ASAALENDKTIKLW 326
Score = 51.6 bits (122), Expect = 2e-06
Identities = 62/278 (22%), Positives = 113/278 (40%), Gaps = 21/278 (7%)
Query: 147 HEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGNAEISTMALDANETR 206
H +AV+ V ++ + + SS + W G+ K G N EIS +A ++ +R
Sbjct: 40 HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYG--HNLEISDVAWSSDSSR 97
Query: 207 LLTGSTDGTVKIWDF-NGYCHHTLNVGQDGAVDISQILILKKKILVTGWERAITVFRPQN 265
L++ S D T+K+WD +G C TL G V I+ ++ + ++
Sbjct: 98 LVSASDDKTLKLWDVRSGKCLKTLK-GHSNYVFCCNFNPPSNLIISGSFDETVKIWE--- 153
Query: 266 FNQFFIQPEEWKGGIQHHDDILCAAFL--PPQTLVTGSYDGEIVLWNNSTENAHHVLHPD 323
++ + + H D + A +V+GSYDG +W+ ++ L D
Sbjct: 154 -----VKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDD 208
Query: 324 YQRLLKSKLDTKPQKLLSAGRSQPSHPMADHSTTGVRNFEIDTEGKNAVMRLCFLKARKN 383
+ + K + + + D+S R + T KN + C N
Sbjct: 209 DNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRG--RCLKTYTGHKNE--KYCIFA---N 261
Query: 384 TAVTGGANLVSCGGSGYVRFWDIYKKQLLAEFLAHSGV 421
+VTGG +VS V W++ K+++ + H+ V
Sbjct: 262 FSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDV 299
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 60.1 bits (144), Expect = 7e-09
Identities = 48/181 (26%), Positives = 75/181 (41%), Gaps = 16/181 (8%)
Query: 57 VLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRIACSFP-KSQDFRCLFH 115
+L+GHS V F +R L S S+D +RLW S+Q C K ++
Sbjct: 538 ILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLW------SLQTFTCLVGYKGHNYPVWDT 591
Query: 116 FDEAHGRLFISFNNQLALLAMKSEASKRVK---SHEKAVTCVLYNSILKQVISSDTGSTV 172
+G F+S + ++ + ++ H V C ++ V + TV
Sbjct: 592 QFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTV 651
Query: 173 SFWMIDTGQKIKQFTGCHGNAEISTMALDANETRLLTGSTDGTVKIWDFNGYCHHTLNVG 232
W + G ++ FTG G I ++ N L TG+TDG V +WD H L VG
Sbjct: 652 RLWDVLNGNCVRIFTGHKG--PIHSLTFSPNGRFLATGATDGRVLLWDIG----HGLMVG 705
Query: 233 Q 233
+
Sbjct: 706 E 706
Score = 37.4 bits (85), Expect = 0.047
Identities = 22/69 (31%), Positives = 36/69 (52%), Gaps = 1/69 (1%)
Query: 22 IHAFDYHSRLNLIATAGINNKVCLWNPYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFS 81
IH+ + +AT + +V LW+ VG L GH+ +V +++F + + L S S
Sbjct: 672 IHSLTFSPNGRFLATGATDGRVLLWD-IGHGLMVGELKGHTDTVCSLRFSRDGEILASGS 730
Query: 82 KDKVLRLWD 90
D +RLWD
Sbjct: 731 MDNTVRLWD 739
Score = 35.8 bits (81), Expect = 0.14
Identities = 47/222 (21%), Positives = 80/222 (36%), Gaps = 30/222 (13%)
Query: 282 HHDDILCAAFLPPQT-LVTGSYDGEIVLWNNSTENAHHVLHPDYQRLLKSKLDTKPQKLL 340
H + A+F P + L++ S DG + LW+ T + ++ +
Sbjct: 542 HSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFV 601
Query: 341 SAGRSQPSHPMADHSTTGVRNFEIDTEGKNAVMRLCFLKARKNTAVTGGANLVSCGGSGY 400
S G + + A +R F G A + N TG A+
Sbjct: 602 SGGHDRVARLWATDHYQPLRIFA----GHLADVNCTRFHPNSNYVATGSADRT------- 650
Query: 401 VRFWDIYKKQLLAEFLAHSG-VGSIIMSTDKMNRYLTTGDLDGWLKIWNIEEYCLNSSKN 459
VR WD+ + F H G + S+ S + R+L TG DG + +W+I
Sbjct: 651 VRLWDVLNGNCVRIFTGHKGPIHSLTFSPN--GRFLATGATDGRVLLWDIGH-------- 700
Query: 460 KITKAPTLIRSFQPHEDRISSLEMCEPGGQLLIISSSADCSI 501
++ + H D + SL G ++ S S D ++
Sbjct: 701 -----GLMVGELKGHTDTVCSLRFSRDGE--ILASGSMDNTV 735
Score = 33.9 bits (76), Expect = 0.52
Identities = 23/89 (25%), Positives = 39/89 (43%), Gaps = 7/89 (7%)
Query: 27 YHSRLNLIATAGINNKVCLWNPYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVL 86
+H N +AT + V LW+ + V + GH + ++ F + L + + D +
Sbjct: 635 FHPNSNYVATGSADRTVRLWD-VLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRV 693
Query: 87 RLWDIQHQLSIQRI------ACSFPKSQD 109
LWDI H L + + CS S+D
Sbjct: 694 LLWDIGHGLMVGELKGHTDTVCSLRFSRD 722
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 59.7 bits (143), Expect = 9e-09
Identities = 51/211 (24%), Positives = 101/211 (47%), Gaps = 17/211 (8%)
Query: 33 LIATAGINNKVCLWNPYVVSKP--VGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWD 90
L+AT G + +V LW+ ++KP + L GH++ V +V+ + + + S+ +R+WD
Sbjct: 35 LLATGGDDCRVNLWS---INKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWD 91
Query: 91 IQHQLSIQRIACSFPKSQDFRCLFHFDEAHGRLFISFNNQLALLAMKSEASK----RVKS 146
++ ++ + K+ FH +G F++ +Q + + K R +
Sbjct: 92 LEAAKILRTLMGH--KANICSLDFH---PYGE-FVASGSQDTNIKLWDIRRKGCVFRYRG 145
Query: 147 HEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGNAEISTMALDANETR 206
H +AV C+ ++ K + S+ TV W + G+ + +F G G ++ + NE
Sbjct: 146 HSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTG--PVNVVEFHPNEYL 203
Query: 207 LLTGSTDGTVKIWDFNGYCHHTLNVGQDGAV 237
L +GS+D T++ WD + + G+ G V
Sbjct: 204 LASGSSDRTIRFWDLEKFQVVSCIEGEPGPV 234
Score = 35.8 bits (81), Expect = 0.14
Identities = 36/168 (21%), Positives = 66/168 (39%), Gaps = 28/168 (16%)
Query: 293 PPQTLVTGSYDGEIVLWNNSTENAHHVLHPDYQRLLKSKLDTKPQKLLSAGRSQPSHPMA 352
P + +V GS G I +W+ L + LD P A SQ
Sbjct: 74 PEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICS--LDFHPYGEFVASGSQD----- 126
Query: 353 DHSTTGVRNFEIDTEGKNAVMRLCFLKARKNTAVT-------GGANLVSCGGSGYVRFWD 405
T ++ ++I +G C + R ++ G L S V+ WD
Sbjct: 127 ----TNIKLWDIRRKG-------CVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWD 175
Query: 406 IYKKQLLAEFLAHSGVGSIIMSTDKMNRY-LTTGDLDGWLKIWNIEEY 452
+ ++++EF H+G +++ N Y L +G D ++ W++E++
Sbjct: 176 LTAGKMMSEFPGHTGPVNVV--EFHPNEYLLASGSSDRTIRFWDLEKF 221
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 59.3 bits (142), Expect = 1e-08
Identities = 73/320 (22%), Positives = 130/320 (40%), Gaps = 32/320 (10%)
Query: 144 VKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGNAEISTMALDAN 203
+ H VT V+++ + ++S+ +T+ W +TG + G H ++ + ++ D +
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKG-HTDS-VQDISFDHS 161
Query: 204 ETRLLTGSTDGTVKIWDFNGY-CHHTLNVGQDGAVDISQILILKKKILVTGWERAITVFR 262
L + S D T+K+WDF G+ C T++ G D V I+ I+ ++ I ++
Sbjct: 162 GKLLASCSADMTIKLWDFQGFECIRTMH-GHDHNVSSVAIMPNGDHIVSASRDKTIKMWE 220
Query: 263 PQN--FNQFFIQPEEWKGGIQ-HHDDILCAAFLPPQT-----LVTGSYDGEIVLWNNSTE 314
Q + F EW ++ + D L A+ QT + T E+ + E
Sbjct: 221 VQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVE 280
Query: 315 NAHHVLHPDYQRL-----LKSKLDTKPQKLLSAGRSQPSHPMADHSTTGVRNFEIDTEGK 369
Y + ++K KP L +G + M D ST + +
Sbjct: 281 CISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHD-- 338
Query: 370 NAVMRLCFLKARKNTAVTGGANLVSCGGSGYVRFWDIYKKQLLAEFLAHSGVGSIIMSTD 429
N V + F +GG ++SC +R WD K+ + AH + S D
Sbjct: 339 NWVRGVLF--------HSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHE---HFVTSLD 387
Query: 430 --KMNRYLTTGDLDGWLKIW 447
K Y+ TG +D +K+W
Sbjct: 388 FHKTAPYVVTGSVDQTVKVW 407
Score = 48.9 bits (115), Expect = 2e-05
Identities = 47/231 (20%), Positives = 100/231 (43%), Gaps = 34/231 (14%)
Query: 24 AFDYHSRLNLIATAGINNKVCLWNPYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKD 83
+FD+ +L +A+ + + LW+ + + + + GH +V +V + S S+D
Sbjct: 157 SFDHSGKL--LASCSADMTIKLWD-FQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRD 213
Query: 84 KVLRLWDIQHQLSIQRIACSFPKSQDFRCLFHFDEAHGRLFISFNNQLAL---LAMKSEA 140
K +++W++Q ++ +F +++ + ++ G L S +N + + E
Sbjct: 214 KTIKMWEVQTGYCVK----TFTGHREWVRMVRPNQ-DGTLIASCSNDQTVRVWVVATKEC 268
Query: 141 SKRVKSHEKAVTCV------LYNSILKQ--------------VISSDTGSTVSFWMIDTG 180
++ HE V C+ Y+SI + ++S T+ W + TG
Sbjct: 269 KAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTG 328
Query: 181 QKIKQFTGCHGNAEISTMALDANETRLLTGSTDGTVKIWDF-NGYCHHTLN 230
+ G H N + + + +L+ + D T+++WD+ N C TLN
Sbjct: 329 MCLMTLVG-HDN-WVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLN 377
Score = 42.4 bits (98), Expect = 0.001
Identities = 36/165 (21%), Positives = 71/165 (43%), Gaps = 10/165 (6%)
Query: 58 LWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRIACSFPKSQDFRCLFHFD 117
L GH + V V F + S S+D +++WD + + + QD FD
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDIS----FD 159
Query: 118 EAHGRLFISFNNQLALLAMKSEASKRVKS---HEKAVTCVLYNSILKQVISSDTGSTVSF 174
+ G+L S + + + + + +++ H+ V+ V ++S+ T+
Sbjct: 160 HS-GKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKM 218
Query: 175 WMIDTGQKIKQFTGCHGNAEISTMALDANETRLLTGSTDGTVKIW 219
W + TG +K FTG + + + + T + + S D TV++W
Sbjct: 219 WEVQTGYCVKTFTG--HREWVRMVRPNQDGTLIASCSNDQTVRVW 261
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 55.5 bits (132), Expect = 2e-07
Identities = 66/291 (22%), Positives = 106/291 (36%), Gaps = 61/291 (20%)
Query: 34 IATAGINNKVCLWNPYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDIQH 93
IAT + LW+ K GH+A ++ + F + + + S D +LWDIQ+
Sbjct: 150 IATGSFDKTCKLWS-VETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQN 208
Query: 94 QLSIQRIACSFPKSQDFRCLFHFDEAHGRLFISFNNQLALLAMKSEASKRVKSHEKAVTC 153
E ++ H +
Sbjct: 209 --------------------------------------------GEEVYTLRGHSAEIIS 224
Query: 154 VLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTG-CHGNAEISTMALDANETRLLTGST 212
+ +N+ ++I+ TV W DTG+K+ G C AEIS+ + + + + +LTGS
Sbjct: 225 LSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHC---AEISSASFNWDCSLILTGSM 281
Query: 213 DGTVKIWD-FNGYCHHTLNVGQDGAVDISQILILKKKILVTGWERAITVFRPQNFNQFFI 271
D T K+WD NG C TL G D + S K I + +F
Sbjct: 282 DKTCKLWDATNGKCVATL-TGHDDEILDSCFDYTGKLIATASADGTARIFSAAT------ 334
Query: 272 QPEEWKGGIQHHDDILCAAFLPPQ--TLVTGSYDGEIVLWNNSTENAHHVL 320
+ ++ H+ + PQ L+TGS D +W+ T VL
Sbjct: 335 --RKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVL 383
Score = 51.2 bits (121), Expect = 3e-06
Identities = 42/201 (20%), Positives = 84/201 (41%), Gaps = 11/201 (5%)
Query: 22 IHAFDYHSRLNLIATAGINNKVCLWNPYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFS 81
I + +++ + I T ++ V +W+ K V +L GH A + + F + + + S
Sbjct: 222 IISLSFNTSGDRIITGSFDHTVVVWDADTGRK-VNILIGHCAEISSASFNWDCSLILTGS 280
Query: 82 KDKVLRLWDIQHQLSIQRIACSFPKSQDFRCLFHFDEAHGRLFISFNNQLALLAMKSEAS 141
DK +LWD + + + D L + G+L + + +
Sbjct: 281 MDKTCKLWDATNGKCVATLT-----GHDDEILDSCFDYTGKLIATASADGTARIFSAATR 335
Query: 142 K---RVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGNAEISTM 198
K +++ HE ++ + +N +++ + T W TGQ ++ G EI +
Sbjct: 336 KCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEG--HTDEIFSC 393
Query: 199 ALDANETRLLTGSTDGTVKIW 219
A + ++TGS D T +IW
Sbjct: 394 AFNYKGNIVITGSKDNTCRIW 414
Score = 47.4 bits (111), Expect = 5e-05
Identities = 55/236 (23%), Positives = 96/236 (40%), Gaps = 14/236 (5%)
Query: 22 IHAFDYHSRLNLIATAGINNKVCLWNPYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFS 81
I ++ + L+AT ++ LW+ + V L GHSA +I++ F ++ + S
Sbjct: 180 IVCLSFNPQSTLVATGSMDTTAKLWD-IQNGEEVYTLRGHSAEIISLSFNTSGDRIITGS 238
Query: 82 KDKVLRLWDIQ--HQLSIQRIACSFPKSQDFRCLFHFDEAHGRLFISFNNQLALL-AMKS 138
D + +WD +++I C+ S F + L S + L A
Sbjct: 239 FDHTVVVWDADTGRKVNILIGHCAEISSASFNW-----DCSLILTGSMDKTCKLWDATNG 293
Query: 139 EASKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGNAEISTM 198
+ + H+ + ++ K + ++ T + T + I + G G EIS +
Sbjct: 294 KCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEG--EISKI 351
Query: 199 ALDANETRLLTGSTDGTVKIWDF-NGYCHHTLNVGQDGAVDISQILILKKKILVTG 253
+ + LLTGS+D T +IWD G C L D S K I++TG
Sbjct: 352 SFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEI--FSCAFNYKGNIVITG 405
Score = 45.4 bits (106), Expect = 2e-04
Identities = 64/312 (20%), Positives = 122/312 (39%), Gaps = 25/312 (8%)
Query: 142 KRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGNAEISTMALD 201
K +K+H +T V N I+ T W +G+++ G H N + +
Sbjct: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEG-HRNVVYAIAFNN 144
Query: 202 ANETRLLTGSTDGTVKIWDFN-GYCHHTLNVGQDGAVDISQILILKKKILVTG-WERAIT 259
++ TGS D T K+W G C+HT V +S + ++ TG +
Sbjct: 145 PYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLS--FNPQSTLVATGSMDTTAK 202
Query: 260 VFRPQNFNQFFIQPEEWKGGIQHHDDILCAAF-LPPQTLVTGSYDGEIVLWNNSTENAHH 318
++ QN + + +G H +I+ +F ++TGS+D +V+W+ T +
Sbjct: 203 LWDIQNGEEVYTL----RG---HSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVN 255
Query: 319 VLHPDYQRLLKSKLDTKPQKLLSAGRSQPSHPMADHSTTGVRNFEIDTEGKNAVMRLCFL 378
+L + + + +L+ G + + D T + T + ++ CF
Sbjct: 256 ILIGHCAEISSASFNWDCSLILT-GSMDKTCKLWD--ATNGKCVATLTGHDDEILDSCFD 312
Query: 379 KARKNTAVTGGANLVSCGGSGYVRFWDIYKKQLLAEFLAHSGVGSIIMSTDKMNRYLTTG 438
G + + G R + ++ +A+ H G S I S + +L TG
Sbjct: 313 YT--------GKLIATASADGTARIFSAATRKCIAKLEGHEGEISKI-SFNPQGNHLLTG 363
Query: 439 DLDGWLKIWNIE 450
D +IW+ +
Sbjct: 364 SSDKTARIWDAQ 375
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 54.3 bits (129), Expect = 4e-07
Identities = 91/424 (21%), Positives = 164/424 (38%), Gaps = 70/424 (16%)
Query: 51 VSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRIACSFPKSQDF 110
V++ L GHS +VI+V F K L S S D +R WD+ ++ F
Sbjct: 103 VTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLS------------TETPHF 150
Query: 111 RCLFHFDEAHGRLFISF------------NNQLALL--AMKSEASKRVKSHEKAVTCVLY 156
C H H L IS+ N Q+ L + + + + H K +T + +
Sbjct: 151 TCKGH---RHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSW 207
Query: 157 -----NSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGNAEISTMALDANETRLLTGS 211
N + V SS +V W G+ + T G+ + T + L + S
Sbjct: 208 EPLHANPECRYVASSSKDGSVRIWDTTAGRCERILT---GHTQSVTCLRWGGDGLLYSAS 264
Query: 212 TDGTVKIW-DFNGYCHHTLNVGQDGAVDISQILILKKKILVTGWERAITVFRPQNFNQFF 270
D T+K+W +G TL Q ++ + + L TG F P +
Sbjct: 265 QDRTIKVWRAHDGVLCRTL---QGHGHWVNTMALSTDYALRTG------AFEPAEAS--- 312
Query: 271 IQPEEWKGGIQHHDDILCAAF-----LPPQTLVTGSYDGEIVLWNNSTENAHHVLHPDYQ 325
+ P++ +G +Q + + + P+ LV+GS D + LW+ + + +Q
Sbjct: 313 VNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQ 372
Query: 326 RLLKSKLDTKPQKLLSAGRSQPSHPMADHSTTGVRNFEIDTEGKNAVMRLCFLKARKNTA 385
L+ L + +++++ S + D T GK + A A
Sbjct: 373 ALINQVLFSPDSRIVASASFDKSIKLWDGRT-----------GKYLASLRGHVAAVYQIA 421
Query: 386 VTGGANLVSCGGS-GYVRFWDIYKKQLLAEFLAHSG-VGSIIMSTDKMNRYLTTGDLDGW 443
+ + L+ G S ++ WD+ ++L + H+ V ++ S D + + +G D
Sbjct: 422 WSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPD--GQRVASGGKDKC 479
Query: 444 LKIW 447
L+IW
Sbjct: 480 LRIW 483
Score = 48.1 bits (113), Expect = 3e-05
Identities = 76/399 (19%), Positives = 144/399 (36%), Gaps = 60/399 (15%)
Query: 138 SEASKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGNAE-IS 196
+ + ++ H +AV V ++ K + S +TV FW + T + FT C G+ +
Sbjct: 104 TRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLST--ETPHFT-CKGHRHWVL 160
Query: 197 TMALDANETRLLTGSTDGTVKIWD---------------------------FNGYCHHTL 229
+++ + +L +G +G + +WD N C +
Sbjct: 161 SISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVA 220
Query: 230 NVGQDGAVDISQILILKKKILVTGWERAITVFRPQNFNQFFIQPEE-----WKGGIQHHD 284
+ +DG+V I + + ++TG +++T R + ++ W+ HD
Sbjct: 221 SSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRA----HD 276
Query: 285 DILCAAFLPPQTLV-TGSYDGEIVLWNNSTENAHHVLHPDYQRLLKSKLDTKPQKLLSAG 343
+LC V T + + L + E A ++P + +L + +
Sbjct: 277 GVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLV 336
Query: 344 RSQPSHPMADHSTTGVRNFEIDTEGKNAVMRLCFLKARKNTAVTGGANLVSCGGS--GYV 401
R Q + S E K + R+ +A N + + + S +
Sbjct: 337 RGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSI 396
Query: 402 RFWDIYKKQLLAEFLAH-SGVGSIIMSTDKMNRYLTTGDLDGWLKIWNIEEYCLNSSKNK 460
+ WD + LA H + V I S D +R L +G D LK+W++
Sbjct: 397 KLWDGRTGKYLASLRGHVAAVYQIAWSAD--SRLLVSGSSDSTLKVWDV----------- 443
Query: 461 ITKAPTLIRSFQPHEDRISSLEMCEPGGQLLIISSSADC 499
KA L H D + +++ P GQ + C
Sbjct: 444 --KAQKLAMDLPGHADEVYAVDW-SPDGQRVASGGKDKC 479
Score = 35.8 bits (81), Expect = 0.14
Identities = 23/70 (32%), Positives = 33/70 (47%), Gaps = 8/70 (11%)
Query: 29 SRLNLIATAGINNKVC--------LWNPYVVSKPVGVLWGHSASVIAVQFFVERKQLFSF 80
SR NL+ G V LW+P KP+ + GH A + V F + + + S
Sbjct: 331 SRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASA 390
Query: 81 SKDKVLRLWD 90
S DK ++LWD
Sbjct: 391 SFDKSIKLWD 400
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 53.5 bits (127), Expect = 6e-07
Identities = 63/235 (26%), Positives = 98/235 (41%), Gaps = 30/235 (12%)
Query: 32 NLIATAGINNKVCLWNPYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDI 91
+L A+A + V LW+ +K + VL GH SV V F + +QL S DK + LWD+
Sbjct: 76 HLFASASCDCTVRLWD-VARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDV 134
Query: 92 Q----------HQLSIQRIACSFPKSQDFRCLFHFDEAHGRLFISFNNQLALLAMKSEAS 141
Q H+ SIQ S S CL A G + + + + +
Sbjct: 135 QSGQMLRLLVGHRDSIQ----SSDFSPTVNCL-----ATGSWDSTVHIWDLRMVTPAVSH 185
Query: 142 KRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGNAEISTMALD 201
+ ++ H ++C+ Y S + S T+ W T + Q G + ++A
Sbjct: 186 QALEGHSANISCLCY-SASGLLASGSWDKTIHIWKPTTSSLLIQLKG--HVTWVKSIAFS 242
Query: 202 ANETRLLTGSTDGTVKIWDFN-GYCHHTLNVGQDGAVDISQILILKK--KILVTG 253
+E L + VK+WD N G C TL G +D++ KILV+G
Sbjct: 243 PDELWLASAGYSRMVKVWDCNTGKCLETLK----GVLDVAHTCAFTPDGKILVSG 293
Score = 37.7 bits (86), Expect = 0.036
Identities = 34/179 (18%), Positives = 62/179 (34%), Gaps = 48/179 (26%)
Query: 137 KSEASKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGNAEIS 196
+++ + +K H+++V V ++ +Q+ S V W + +GQ ++ G + + S
Sbjct: 94 RAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSS 153
Query: 197 TMALDANETRLLTGSTDGTVKIWDFNGYCHHTLNVGQDGAVDISQILILKKKILVTGWER 256
+ N L TGS D TV IWD + +G
Sbjct: 154 DFSPTVN--CLATGSWDSTVHIWDLRMVTPAVSHQALEG--------------------- 190
Query: 257 AITVFRPQNFNQFFIQPEEWKGGIQHHDDILCAAFLPPQTLVTGSYDGEIVLWNNSTEN 315
H +I C + L +GS+D I +W +T +
Sbjct: 191 -------------------------HSANISCLCYSASGLLASGSWDKTIHIWKPTTSS 224
Score = 31.2 bits (69), Expect = 3.4
Identities = 24/91 (26%), Positives = 44/91 (48%), Gaps = 4/91 (4%)
Query: 1 MAWREKSKKRLNMTSFNIAQGIHAFDYHSRLNLIATAGINNKVCLWNPYVVSKPVG--VL 58
M W +S + L + + I + D+ +N +AT ++ V +W+ +V+ V L
Sbjct: 130 MLWDVQSGQMLRLLVGH-RDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQAL 188
Query: 59 WGHSASVIAVQFFVERKQLFSFSKDKVLRLW 89
GHSA++ + + L S S DK + +W
Sbjct: 189 EGHSANISCLCYSAS-GLLASGSWDKTIHIW 218
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
[Homo sapiens]
Length = 340
Score = 52.8 bits (125), Expect = 1e-06
Identities = 42/180 (23%), Positives = 77/180 (42%), Gaps = 18/180 (10%)
Query: 58 LWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRI--------ACSFPKSQD 109
L GH A + A+ + + + L S S+D L +WD + I C++ S +
Sbjct: 51 LRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGN 110
Query: 110 FRCLFHFDEAHGRLFISFNNQLALLAMKSEASKRVKSHEKAVTCVLYNSILKQVISSDTG 169
+ D I L S+ + H ++C + Q+++S
Sbjct: 111 YVACGGLDN------ICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD-NQIVTSSGD 163
Query: 170 STVSFWMIDTGQKIKQFTGCHGNAEISTMALDANETRLLTGSTDGTVKIWDF-NGYCHHT 228
+T + W I+TGQ+ FTG G ++ +++L + ++G+ D + K+WD G C T
Sbjct: 164 TTCALWDIETGQQTTTFTGHTG--DVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQT 221
Score = 35.4 bits (80), Expect = 0.18
Identities = 41/207 (19%), Positives = 72/207 (34%), Gaps = 26/207 (12%)
Query: 297 LVTGSYDGEIVLWNNSTENAHHVLHPDYQRLLKSKLDTKPQKLLSAGRSQPSHPMADHST 356
LV+ S DG++++W++ T N H + ++ + G +
Sbjct: 70 LVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTR 129
Query: 357 TGVRNFEIDTEGKNAVMRLC-FLKARKNTAVTGGANLVSCGGSGYVRFWDIYKKQLLAEF 415
G + G + C FL + +V+ G WDI Q F
Sbjct: 130 EGNVRVSRELAGHTGYLSCCRFLDDNQ---------IVTSSGDTTCALWDIETGQQTTTF 180
Query: 416 LAHSG-VGSIIMSTDKMNRYLTTGDLDGWLKIWNIEEYCLNSSKNKITKAPTLIRSFQPH 474
H+G V S+ ++ D R +G D K+W++ E ++F H
Sbjct: 181 TGHTGDVMSLSLAPD--TRLFVSGACDASAKLWDVREGMCR-------------QTFTGH 225
Query: 475 EDRISSLEMCEPGGQLLIISSSADCSI 501
E I+++ G S A C +
Sbjct: 226 ESDINAICFFPNGNAFATGSDDATCRL 252
>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
[Homo sapiens]
Length = 340
Score = 52.4 bits (124), Expect = 1e-06
Identities = 43/195 (22%), Positives = 87/195 (44%), Gaps = 29/195 (14%)
Query: 58 LWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRI--------ACSFPKSQD 109
L GH A + A+ + + + L S S+D L +WD + I C++ S +
Sbjct: 51 LRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGN 110
Query: 110 FRCLFHFDEAHGRLFISFNNQLALLAMKSE-----ASKRVKSHEKAVTCVLYNSILKQVI 164
F D N ++ ++K+ S+ + H ++C + Q+I
Sbjct: 111 FVACGGLD-----------NICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDD-NQII 158
Query: 165 SSDTGSTVSFWMIDTGQKIKQFTGCHGNAEISTMALDANETRLLTGSTDGTVKIWDF-NG 223
+S +T + W I+TGQ+ F G G ++ +++L + ++G+ D ++K+WD +
Sbjct: 159 TSSGDTTCALWDIETGQQTVGFAGHSG--DVMSLSLAPDGRTFVSGACDASIKLWDVRDS 216
Query: 224 YCHHTLNVGQDGAVD 238
C T +G + ++
Sbjct: 217 MCRQTF-IGHESDIN 230
Score = 35.4 bits (80), Expect = 0.18
Identities = 32/157 (20%), Positives = 60/157 (38%), Gaps = 13/157 (8%)
Query: 297 LVTGSYDGEIVLWNNSTENAHHVLHPDYQRLLKSKLDTKPQKLLSAGRSQPSHPMADHST 356
LV+ S DG++++W++ T N H + ++ + G + +
Sbjct: 70 LVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTR 129
Query: 357 TGVRNFEIDTEGKNAVMRLC-FLKARKNTAVTGGANLVSCGGSGYVRFWDIYKKQLLAEF 415
G + G + C FL + +++ G WDI Q F
Sbjct: 130 EGNVRVSRELPGHTGYLSCCRFLDDNQ---------IITSSGDTTCALWDIETGQQTVGF 180
Query: 416 LAHSG-VGSIIMSTDKMNRYLTTGDLDGWLKIWNIEE 451
HSG V S+ ++ D R +G D +K+W++ +
Sbjct: 181 AGHSGDVMSLSLAPD--GRTFVSGACDASIKLWDVRD 215
>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
sapiens]
Length = 340
Score = 52.0 bits (123), Expect = 2e-06
Identities = 45/185 (24%), Positives = 86/185 (46%), Gaps = 28/185 (15%)
Query: 58 LWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDIQ-----HQLSIQR---IACSFPKSQD 109
L GH A + A+ + + K L S S+D L +WD H + ++ + C++ S +
Sbjct: 51 LRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGN 110
Query: 110 FRCLFHFDEAHGRLFISFNNQLALLAMKS-----EASKRVKSHEKAVTCVLYNSILKQVI 164
F A G L +N ++ +KS + S+ + +H ++C + ++
Sbjct: 111 F-------VACGGL----DNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDD-NNIV 158
Query: 165 SSDTGSTVSFWMIDTGQKIKQFTGCHGNAEISTMALDANETRLLTGSTDGTVKIWDF-NG 223
+S +T + W I+TGQ+ F G G + ++A+ + ++G+ D + K+WD G
Sbjct: 159 TSSGDTTCALWDIETGQQKTVFVGHTG--DCMSLAVSPDFNLFISGACDASAKLWDVREG 216
Query: 224 YCHHT 228
C T
Sbjct: 217 TCRQT 221
Score = 35.8 bits (81), Expect = 0.14
Identities = 40/206 (19%), Positives = 72/206 (34%), Gaps = 24/206 (11%)
Query: 297 LVTGSYDGEIVLWNNSTENAHHVLHPDYQRLLKSKLDTKPQKLLSAGRSQPSHPMADHST 356
LV+ S DG++++W++ T N H + ++ + G S
Sbjct: 70 LVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSR 129
Query: 357 TGVRNFEIDTEGKNAVMRLC-FLKARKNTAVTGGANLVSCGGSGYVRFWDIYKKQLLAEF 415
G + + C FL N+V+ G WDI Q F
Sbjct: 130 EGNVKVSRELSAHTGYLSCCRFLDDN---------NIVTSSGDTTCALWDIETGQQKTVF 180
Query: 416 LAHSGVGSIIMSTDKMNRYLTTGDLDGWLKIWNIEEYCLNSSKNKITKAPTLIRSFQPHE 475
+ H+G + + N ++ +G D K+W++ E T ++F HE
Sbjct: 181 VGHTGDCMSLAVSPDFNLFI-SGACDASAKLWDVRE-------------GTCRQTFTGHE 226
Query: 476 DRISSLEMCEPGGQLLIISSSADCSI 501
I+++ G + S A C +
Sbjct: 227 SDINAICFFPNGEAICTGSDDASCRL 252
Score = 32.3 bits (72), Expect = 1.5
Identities = 42/202 (20%), Positives = 80/202 (39%), Gaps = 29/202 (14%)
Query: 32 NLIATAGINNKVCLWNPYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDI 91
N I T+ + LW+ + V GH+ +++ + S + D +LWD+
Sbjct: 155 NNIVTSSGDTTCALWD-IETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDV 213
Query: 92 Q----------HQLSIQRIACSFPKSQDFRCLFHFDEAHGRLFISFNNQLALLAMKSEAS 141
+ H+ I I C FP + D+A RLF ++++
Sbjct: 214 REGTCRQTFTGHESDINAI-CFFPNGEAI--CTGSDDASCRLF----------DLRADQE 260
Query: 142 KRVKSHEK---AVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGNAEISTM 198
SHE +T V ++ + + + + W +++ +G H N +S +
Sbjct: 261 LICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSG-HDN-RVSCL 318
Query: 199 ALDANETRLLTGSTDGTVKIWD 220
+ A+ + TGS D +KIW+
Sbjct: 319 GVTADGMAVATGSWDSFLKIWN 340
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 52.0 bits (123), Expect = 2e-06
Identities = 58/275 (21%), Positives = 111/275 (40%), Gaps = 42/275 (15%)
Query: 58 LWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDIQ----------HQLSIQRIACSFPKS 107
L GH+ +V +V+F + L S S DK++++W H+L I +A S
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS---- 96
Query: 108 QDFRCLFHFDEAHGRLFISFNNQLALL---AMKSEASKRVKSHEKAVTCVLYNSILKQVI 164
+ L +S ++ L + K +K H V C +N ++
Sbjct: 97 -----------SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIV 145
Query: 165 SSDTGSTVSFWMIDTGQKIKQFTGCHGNAEISTMALDANETRLLTGSTDGTVKIWD-FNG 223
S +V W + TG+ +K H + +S + + + + +++ S DG +IWD +G
Sbjct: 146 SGSFDESVRIWDVKTGKCLKTLP-AHSD-PVSAVHFNRDGSLIVSSSYDGLCRIWDTASG 203
Query: 224 YCHHTLNVGQDGAVDISQILILKKKILVTGWERAITVFRPQNFNQFFIQPEEWKGGIQHH 283
C TL + V + K IL + + ++ + + + K H
Sbjct: 204 QCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD-------YSKGKCLKTYTGHK 256
Query: 284 DDILCA----AFLPPQTLVTGSYDGEIVLWNNSTE 314
++ C + + +V+GS D + +WN T+
Sbjct: 257 NEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTK 291
Score = 47.4 bits (111), Expect = 5e-05
Identities = 62/277 (22%), Positives = 110/277 (39%), Gaps = 19/277 (6%)
Query: 147 HEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGNAEISTMALDANETR 206
H KAV+ V ++ + + SS + W G+ K +G IS +A ++
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG--HKLGISDVAWSSDSNL 101
Query: 207 LLTGSTDGTVKIWDFN-GYCHHTLNVGQDGAVDISQILILKKKILVTGWERAITVFRPQN 265
L++ S D T+KIWD + G C TL G V I+ ++ ++ ++ +
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLK-GHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160
Query: 266 FNQFFIQPEEWKGGIQHHDDILCAAFLPPQTL-VTGSYDGEIVLWNNSTENAHHVLHPDY 324
P H D + F +L V+ SYDG +W+ ++ L D
Sbjct: 161 GKCLKTLPA-------HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213
Query: 325 QRLLKSKLDTKPQKLLSAGRSQPSHPMADHSTTGVRNFEIDTEGKNAVMRLCFLKARKNT 384
+ + K + A + + D+S + + T KN + C N
Sbjct: 214 NPPVSFVKFSPNGKYILAATLDNTLKLWDYSKG--KCLKTYTGHKNE--KYCIFA---NF 266
Query: 385 AVTGGANLVSCGGSGYVRFWDIYKKQLLAEFLAHSGV 421
+VTGG +VS V W++ K+++ + H+ V
Sbjct: 267 SVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDV 303
Score = 44.7 bits (104), Expect = 3e-04
Identities = 48/207 (23%), Positives = 90/207 (43%), Gaps = 15/207 (7%)
Query: 21 GIHAFDYHSRLNLIATAGINNKVCLWNPYVVSKPVGVLWGHSASVIAVQFFVERKQLFSF 80
GI + S NL+ +A + + +W+ K + L GHS V F + + S
Sbjct: 89 GISDVAWSSDSNLLVSASDDKTLKIWD-VSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG 147
Query: 81 SKDKVLRLWDIQHQLSIQRIACSFPKSQDFRCLFHFDEAHGRLFISFNNQLALLAMKSEA 140
S D+ +R+WD++ ++ + P D HF+ G L +S ++ L + A
Sbjct: 148 SFDESVRIWDVKTGKCLK----TLPAHSDPVSAVHFNR-DGSLIVS-SSYDGLCRIWDTA 201
Query: 141 SKR-----VKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGNAEI 195
S + + V+ V ++ K ++++ +T+ W G+ +K +TG H N +
Sbjct: 202 SGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG-HKNEKY 260
Query: 196 STMA--LDANETRLLTGSTDGTVKIWD 220
A +++GS D V IW+
Sbjct: 261 CIFANFSVTGGKWIVSGSEDNLVYIWN 287
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 52.0 bits (123), Expect = 2e-06
Identities = 58/275 (21%), Positives = 111/275 (40%), Gaps = 42/275 (15%)
Query: 58 LWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDIQ----------HQLSIQRIACSFPKS 107
L GH+ +V +V+F + L S S DK++++W H+L I +A S
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS---- 96
Query: 108 QDFRCLFHFDEAHGRLFISFNNQLALL---AMKSEASKRVKSHEKAVTCVLYNSILKQVI 164
+ L +S ++ L + K +K H V C +N ++
Sbjct: 97 -----------SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIV 145
Query: 165 SSDTGSTVSFWMIDTGQKIKQFTGCHGNAEISTMALDANETRLLTGSTDGTVKIWD-FNG 223
S +V W + TG+ +K H + +S + + + + +++ S DG +IWD +G
Sbjct: 146 SGSFDESVRIWDVKTGKCLKTLP-AHSD-PVSAVHFNRDGSLIVSSSYDGLCRIWDTASG 203
Query: 224 YCHHTLNVGQDGAVDISQILILKKKILVTGWERAITVFRPQNFNQFFIQPEEWKGGIQHH 283
C TL + V + K IL + + ++ + + + K H
Sbjct: 204 QCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD-------YSKGKCLKTYTGHK 256
Query: 284 DDILCA----AFLPPQTLVTGSYDGEIVLWNNSTE 314
++ C + + +V+GS D + +WN T+
Sbjct: 257 NEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTK 291
Score = 47.4 bits (111), Expect = 5e-05
Identities = 62/277 (22%), Positives = 110/277 (39%), Gaps = 19/277 (6%)
Query: 147 HEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGNAEISTMALDANETR 206
H KAV+ V ++ + + SS + W G+ K +G IS +A ++
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG--HKLGISDVAWSSDSNL 101
Query: 207 LLTGSTDGTVKIWDFN-GYCHHTLNVGQDGAVDISQILILKKKILVTGWERAITVFRPQN 265
L++ S D T+KIWD + G C TL G V I+ ++ ++ ++ +
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLK-GHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160
Query: 266 FNQFFIQPEEWKGGIQHHDDILCAAFLPPQTL-VTGSYDGEIVLWNNSTENAHHVLHPDY 324
P H D + F +L V+ SYDG +W+ ++ L D
Sbjct: 161 GKCLKTLPA-------HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213
Query: 325 QRLLKSKLDTKPQKLLSAGRSQPSHPMADHSTTGVRNFEIDTEGKNAVMRLCFLKARKNT 384
+ + K + A + + D+S + + T KN + C N
Sbjct: 214 NPPVSFVKFSPNGKYILAATLDNTLKLWDYSKG--KCLKTYTGHKNE--KYCIFA---NF 266
Query: 385 AVTGGANLVSCGGSGYVRFWDIYKKQLLAEFLAHSGV 421
+VTGG +VS V W++ K+++ + H+ V
Sbjct: 267 SVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDV 303
Score = 44.7 bits (104), Expect = 3e-04
Identities = 48/207 (23%), Positives = 90/207 (43%), Gaps = 15/207 (7%)
Query: 21 GIHAFDYHSRLNLIATAGINNKVCLWNPYVVSKPVGVLWGHSASVIAVQFFVERKQLFSF 80
GI + S NL+ +A + + +W+ K + L GHS V F + + S
Sbjct: 89 GISDVAWSSDSNLLVSASDDKTLKIWD-VSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG 147
Query: 81 SKDKVLRLWDIQHQLSIQRIACSFPKSQDFRCLFHFDEAHGRLFISFNNQLALLAMKSEA 140
S D+ +R+WD++ ++ + P D HF+ G L +S ++ L + A
Sbjct: 148 SFDESVRIWDVKTGKCLK----TLPAHSDPVSAVHFNR-DGSLIVS-SSYDGLCRIWDTA 201
Query: 141 SKR-----VKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGNAEI 195
S + + V+ V ++ K ++++ +T+ W G+ +K +TG H N +
Sbjct: 202 SGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG-HKNEKY 260
Query: 196 STMA--LDANETRLLTGSTDGTVKIWD 220
A +++GS D V IW+
Sbjct: 261 CIFANFSVTGGKWIVSGSEDNLVYIWN 287
>gi|18874090 WD repeat domain 48 [Homo sapiens]
Length = 677
Score = 50.8 bits (120), Expect = 4e-06
Identities = 47/233 (20%), Positives = 97/233 (41%), Gaps = 28/233 (12%)
Query: 21 GIHAFDYHSRLNLIATAGINNKVCLWN-------PYVVSKPVGVLWGHSASVIAVQFFVE 73
G++A LN + TAG ++ + +W+ PY+ S + H+ V +
Sbjct: 32 GVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIAS-----MEHHTDWVNDIVLCCN 86
Query: 74 RKQLFSFSKDKVLRLWDIQHQLSIQRI--------ACSFPKSQDFRCLFHFDEAHGRLFI 125
K L S S D +++W+ + + A ++ K ++ D ++F+
Sbjct: 87 GKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDR---QIFL 143
Query: 126 SFNNQLALLAMKSEA--SKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKI 183
N L L + + + ++ ++ + N + ++S T + W T K+
Sbjct: 144 WDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKL 203
Query: 184 KQFTGCHGNAEISTMALDANETRLLTGSTDGTVKIWDFNGY-CHHTLNVGQDG 235
+ G N + + L+ + T+ L+GS+DGT+++W C T V +G
Sbjct: 204 MKLKGHTDN--VKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEG 254
>gi|53729352 WD repeat-containing protein 1 isoform 2 [Homo sapiens]
Length = 466
Score = 50.8 bits (120), Expect = 4e-06
Identities = 57/241 (23%), Positives = 101/241 (41%), Gaps = 35/241 (14%)
Query: 32 NLIATAGINNKVCLWNPYVVSK--PVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLW 89
N ATA + ++ +++ K +G H + A+ + + L S S DK ++W
Sbjct: 62 NRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIW 121
Query: 90 DIQHQLSIQRIACSFPK-----SQDFRCLFHFDEAHGRLFISFNNQLALLAMK--SEASK 142
D+ S+ + +FP Q CL+ D L +S + + L S+
Sbjct: 122 DV----SVNSVVSTFPMGSTVLDQQLGCLWQKDHL---LSVSLSGYINYLDRNNPSKPLH 174
Query: 143 RVKSHEKAVTC--VLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGNAEISTMAL 200
+K H K++ C V N + S +++W +TG+ F G ++S M +
Sbjct: 175 VIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGEN-DSFAGKGHTNQVSRMTV 233
Query: 201 DANETRLLTGSTDGTVK-----IWDFNGYCHHTLNV----------GQDGAVDISQILIL 245
D +L++ S D TV+ + D++G L+V G V I QI++L
Sbjct: 234 D-ESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVVCIGQIVLL 292
Query: 246 K 246
K
Sbjct: 293 K 293
>gi|9257257 WD repeat-containing protein 1 isoform 1 [Homo sapiens]
Length = 606
Score = 50.8 bits (120), Expect = 4e-06
Identities = 57/241 (23%), Positives = 101/241 (41%), Gaps = 35/241 (14%)
Query: 32 NLIATAGINNKVCLWNPYVVSK--PVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLW 89
N ATA + ++ +++ K +G H + A+ + + L S S DK ++W
Sbjct: 202 NRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIW 261
Query: 90 DIQHQLSIQRIACSFPK-----SQDFRCLFHFDEAHGRLFISFNNQLALLAMK--SEASK 142
D+ S+ + +FP Q CL+ D L +S + + L S+
Sbjct: 262 DV----SVNSVVSTFPMGSTVLDQQLGCLWQKDHL---LSVSLSGYINYLDRNNPSKPLH 314
Query: 143 RVKSHEKAVTC--VLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGNAEISTMAL 200
+K H K++ C V N + S +++W +TG+ F G ++S M +
Sbjct: 315 VIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGEN-DSFAGKGHTNQVSRMTV 373
Query: 201 DANETRLLTGSTDGTVK-----IWDFNGYCHHTLNV----------GQDGAVDISQILIL 245
D +L++ S D TV+ + D++G L+V G V I QI++L
Sbjct: 374 D-ESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVVCIGQIVLL 432
Query: 246 K 246
K
Sbjct: 433 K 433
>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
sapiens]
Length = 513
Score = 50.8 bits (120), Expect = 4e-06
Identities = 40/154 (25%), Positives = 69/154 (44%), Gaps = 10/154 (6%)
Query: 145 KSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGNAEISTMALDANE 204
++H K VTC+ ++ Q++S+ T+ + +G+ +K+F G +T D +
Sbjct: 304 RAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGH- 362
Query: 205 TRLLTGSTDGTVKIWDF-NGYCHHTL-NVGQDGAVDI---SQILILKKKILVTGWERAIT 259
+++ S+DGTVKIW+ C +T ++G DI S IL+ K R+ T
Sbjct: 363 -YIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNT 421
Query: 260 VFRPQNFNQFFIQPEEWKGGIQHHDDILCAAFLP 293
V Q + G + D +C A P
Sbjct: 422 VVIMNMQGQIV---RSFSSGKREGGDFVCCALSP 452
Score = 36.6 bits (83), Expect = 0.081
Identities = 23/125 (18%), Positives = 53/125 (42%), Gaps = 22/125 (17%)
Query: 136 MKSEASKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGNAEI 195
+K +A + AV C+ ++ + + + + W I +GQ +++F H +
Sbjct: 252 LKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKG-V 310
Query: 196 STMALDANETRLLTGSTDGTVKIW---------DFNGYC------------HHTLNVGQD 234
+ ++ + +++L+ S D T++I +F G+ H+ ++ D
Sbjct: 311 TCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSD 370
Query: 235 GAVDI 239
G V I
Sbjct: 371 GTVKI 375
Score = 33.1 bits (74), Expect = 0.89
Identities = 37/188 (19%), Positives = 77/188 (40%), Gaps = 22/188 (11%)
Query: 138 SEASKRVKSHEKA-VTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGNAEIS 196
++ S+ +K +K+ V C ++ + +++ + W TG+ K A+ +
Sbjct: 203 TQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKY---QAQDN 259
Query: 197 TMALD--------ANETRLL-TGSTDGTVKIWDF-NGYCHHTLNVGQDGAVDISQILILK 246
M +D + +T +L TG+ DG +K+W +G C V
Sbjct: 260 FMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDS 319
Query: 247 KKILVTGWERAITVFRPQNFNQFFIQPEEWKGGIQHHDDILCAAFLPP-QTLVTGSYDGE 305
+IL +++ I + ++ +E++G H + A F +++ S DG
Sbjct: 320 SQILSASFDQTIRIHGLKSGKTL----KEFRG---HSSFVNEATFTQDGHYIISASSDGT 372
Query: 306 IVLWNNST 313
+ +WN T
Sbjct: 373 VKIWNMKT 380
>gi|142976686 nuclear autoantigen isoform 1 [Homo sapiens]
Length = 797
Score = 50.4 bits (119), Expect = 5e-06
Identities = 54/215 (25%), Positives = 97/215 (45%), Gaps = 39/215 (18%)
Query: 36 TAGINNKVCLWN-------PYVVSKP---VGVLWGHSASVIAVQFFVERKQLFSFSKDKV 85
+ GI+ + WN PY +P G L GH+ +V + + + QL S S D
Sbjct: 550 SGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGT 609
Query: 86 LRLWDIQHQLSIQRIACSF--------PKSQDFRCLFHFDEAHGRLFISFNNQLA----- 132
+RLW+ Q +L C++ P S DF D AH + SFN A
Sbjct: 610 VRLWNPQEKLP---CICTYNGDKKHGIPTSVDF---IGCDPAH--MVTSFNTGSAVIYDL 661
Query: 133 -----LLAMKSEASKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFT 187
L+ + S+ ++S+ + V+ + L I++ + F+ TG+ I
Sbjct: 662 ETSQSLVILSSQVDSGLQSNNH-INRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMV 720
Query: 188 GCHGNAEISTMALDANETRLLTGSTDGTVKIWDFN 222
H +A ++++A+D N L++GS D ++++W+ +
Sbjct: 721 -AHLDA-VTSLAVDPNGIYLMSGSHDCSIRLWNLD 753
Score = 30.8 bits (68), Expect = 4.4
Identities = 59/301 (19%), Positives = 116/301 (38%), Gaps = 38/301 (12%)
Query: 144 VKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQ---------FTGCHGNAE 194
++SH V + ++ + ++++ T+ W + K+ +T
Sbjct: 476 LRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIGP 535
Query: 195 ISTMALDANETRLLTGSTDGTVKIWD--------FNGYCHHTLN---VGQDGAVDISQIL 243
+ ++A+ +N + +G D T++ W+ ++ Y + L VG AV
Sbjct: 536 VLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYS 595
Query: 244 ILKKKILVTGWERAITVFRPQ-NFNQFFIQPEEWKGGIQHHDDILCAAFLPPQTLVTGSY 302
+K ++L + + ++ PQ + K GI D + P +VT
Sbjct: 596 GIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGC---DPAHMVTSFN 652
Query: 303 DGEIVLWNNSTENAHHVLHPDYQRLLKSKLDTKPQKLLSAGR--SQPSHP--MADHSTTG 358
G V+++ T + +L S++D+ Q R S P+ P + H
Sbjct: 653 TGSAVIYDLETSQS--------LVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRH 704
Query: 359 VRNFEIDTEGKNAVMRLCFLKARKNTAV-TGGANLVSCGGSGYVRFWDIYKKQLLAEFLA 417
++ F+ T GK + L A + AV G L+S +R W++ K + E A
Sbjct: 705 IKFFDNKT-GKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITA 763
Query: 418 H 418
H
Sbjct: 764 H 764
>gi|142976675 nuclear autoantigen isoform 2 [Homo sapiens]
Length = 713
Score = 50.4 bits (119), Expect = 5e-06
Identities = 54/215 (25%), Positives = 97/215 (45%), Gaps = 39/215 (18%)
Query: 36 TAGINNKVCLWN-------PYVVSKP---VGVLWGHSASVIAVQFFVERKQLFSFSKDKV 85
+ GI+ + WN PY +P G L GH+ +V + + + QL S S D
Sbjct: 466 SGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGT 525
Query: 86 LRLWDIQHQLSIQRIACSF--------PKSQDFRCLFHFDEAHGRLFISFNNQLA----- 132
+RLW+ Q +L C++ P S DF D AH + SFN A
Sbjct: 526 VRLWNPQEKLP---CICTYNGDKKHGIPTSVDF---IGCDPAH--MVTSFNTGSAVIYDL 577
Query: 133 -----LLAMKSEASKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFT 187
L+ + S+ ++S+ + V+ + L I++ + F+ TG+ I
Sbjct: 578 ETSQSLVILSSQVDSGLQSNNH-INRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMV 636
Query: 188 GCHGNAEISTMALDANETRLLTGSTDGTVKIWDFN 222
H +A ++++A+D N L++GS D ++++W+ +
Sbjct: 637 -AHLDA-VTSLAVDPNGIYLMSGSHDCSIRLWNLD 669
Score = 30.8 bits (68), Expect = 4.4
Identities = 59/301 (19%), Positives = 116/301 (38%), Gaps = 38/301 (12%)
Query: 144 VKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQ---------FTGCHGNAE 194
++SH V + ++ + ++++ T+ W + K+ +T
Sbjct: 392 LRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIGP 451
Query: 195 ISTMALDANETRLLTGSTDGTVKIWD--------FNGYCHHTLN---VGQDGAVDISQIL 243
+ ++A+ +N + +G D T++ W+ ++ Y + L VG AV
Sbjct: 452 VLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYS 511
Query: 244 ILKKKILVTGWERAITVFRPQ-NFNQFFIQPEEWKGGIQHHDDILCAAFLPPQTLVTGSY 302
+K ++L + + ++ PQ + K GI D + P +VT
Sbjct: 512 GIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGC---DPAHMVTSFN 568
Query: 303 DGEIVLWNNSTENAHHVLHPDYQRLLKSKLDTKPQKLLSAGR--SQPSHP--MADHSTTG 358
G V+++ T + +L S++D+ Q R S P+ P + H
Sbjct: 569 TGSAVIYDLETSQS--------LVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRH 620
Query: 359 VRNFEIDTEGKNAVMRLCFLKARKNTAV-TGGANLVSCGGSGYVRFWDIYKKQLLAEFLA 417
++ F+ T GK + L A + AV G L+S +R W++ K + E A
Sbjct: 621 IKFFDNKT-GKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITA 679
Query: 418 H 418
H
Sbjct: 680 H 680
>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
[Homo sapiens]
Length = 340
Score = 50.1 bits (118), Expect = 7e-06
Identities = 40/180 (22%), Positives = 80/180 (44%), Gaps = 18/180 (10%)
Query: 58 LWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDI-----QHQLSIQR---IACSFPKSQD 109
L GH A + A+ + + + L S S+D L +WD H + ++ + C++ S +
Sbjct: 51 LRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGN 110
Query: 110 FRCLFHFDEAHGRLFISFNNQLALLAMKSEASKRVKSHEKAVTCVLYNSILKQVISSDTG 169
+ D I L S+ + H ++C + Q+++S
Sbjct: 111 YVACGGLDN------ICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDD-SQIVTSSGD 163
Query: 170 STVSFWMIDTGQKIKQFTGCHGNAEISTMALDANETRLLTGSTDGTVKIWDF-NGYCHHT 228
+T + W I+T Q+ FTG G ++ +++L + ++G+ D + K+WD +G C +
Sbjct: 164 TTCALWDIETAQQTTTFTGHSG--DVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQS 221
Score = 36.2 bits (82), Expect = 0.11
Identities = 33/156 (21%), Positives = 56/156 (35%), Gaps = 11/156 (7%)
Query: 297 LVTGSYDGEIVLWNNSTENAHHVLHPDYQRLLKSKLDTKPQKLLSAGRSQPSHPMADHST 356
LV+ S DG++++W++ T N H + ++ + G +
Sbjct: 70 LVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTR 129
Query: 357 TGVRNFEIDTEGKNAVMRLCFLKARKNTAVTGGANLVSCGGSGYVRFWDIYKKQLLAEFL 416
G + G + C + +V+ G WDI Q F
Sbjct: 130 EGNVRVSRELPGHTGYLSCC--------RFLDDSQIVTSSGDTTCALWDIETAQQTTTFT 181
Query: 417 AHSG-VGSIIMSTDKMNRYLTTGDLDGWLKIWNIEE 451
HSG V S+ +S D R +G D K+W+I +
Sbjct: 182 GHSGDVMSLSLSPDM--RTFVSGACDASSKLWDIRD 215
>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
Length = 943
Score = 50.1 bits (118), Expect = 7e-06
Identities = 44/212 (20%), Positives = 87/212 (41%), Gaps = 42/212 (19%)
Query: 49 YVVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSI-------QRIA 101
YV S GV+ +++ V E+ + + + + +WD++ I Q +
Sbjct: 10 YVASAVFGVIGSQKGNIVFVTLRGEKGRYVAVPACEHVFIWDLRKGEKILILQGLKQEVT 69
Query: 102 CSFPKSQDFRCLFHFDEAHGRLF--------ISFN-NQLALLAMK--------SEASK-- 142
C P +++ R+F ++FN ++ A+ +K + SK
Sbjct: 70 CLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDT 129
Query: 143 --------------RVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTG 188
R+K H+ A+T L+ +++S + V +W +DT K G
Sbjct: 130 DIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVG 189
Query: 189 CHGNAEISTMALDANETRLLTGSTDGTVKIWD 220
E+ + L + E RL+TG++D +++WD
Sbjct: 190 --HRTEVWGLVLLSEEKRLITGASDSELRVWD 219
Score = 49.3 bits (116), Expect = 1e-05
Identities = 47/170 (27%), Positives = 72/170 (42%), Gaps = 14/170 (8%)
Query: 148 EKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGNA-EISTMALDANETR 206
++ V CV Y+ K + S TV + +DT +K F +G+ + M + +
Sbjct: 549 DEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDT---LKFFLSLYGHKLPVICMDISHDGAL 605
Query: 207 LLTGSTDGTVKIWDFN-GYCHHTLNVGQDGAVDISQILILKKKILVTGWERAITVFRPQN 265
+ TGS D VKIW + G CH +L D +V Q + G + I +
Sbjct: 606 IATGSADRNVKIWGLDFGDCHKSL-FAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADK 664
Query: 266 FNQFFIQPEEWKGGIQHHDDILCAAFLPP-QTLVTGSYDGEIVLWNNSTE 314
F IQ E HH +I C A P +V+ S+D + LW + E
Sbjct: 665 FEH--IQTLE-----GHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTRE 707
Score = 32.0 bits (71), Expect = 2.0
Identities = 19/67 (28%), Positives = 31/67 (46%), Gaps = 1/67 (1%)
Query: 32 NLIATAGINNKVCLWNPYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDI 91
NL+ T+G + V W+ + GH V + E K+L + + D LR+WDI
Sbjct: 162 NLLVTSGKDTMVKWWD-LDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220
Query: 92 QHQLSIQ 98
+ I+
Sbjct: 221 AYLQEIE 227
>gi|4759276 RNA, U3 small nucleolar interacting protein 2 [Homo
sapiens]
Length = 475
Score = 49.3 bits (116), Expect = 1e-05
Identities = 61/263 (23%), Positives = 100/263 (38%), Gaps = 47/263 (17%)
Query: 52 SKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRIACSFPKSQDFR 111
S + VL GH S+ + + +FS +KD + W ++ + I P++
Sbjct: 136 SADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVI----PRA---- 187
Query: 112 CLFHFDEAHGRLFISFNNQLALLAMKSEASKRVKSHEKAVTCVLYNSILKQVISSDTGST 171
K A + H V C+ +S K + S D
Sbjct: 188 -------------------------KKGAEGKPPGHSSHVLCMAISSDGKYLASGDRSKL 222
Query: 172 VSFWMIDTGQKIKQFTGCHGNAEISTMALDANETRLLTGSTDGTVKIWDF--NGYCHHTL 229
+ W + Q + FTG H +A +S +A +L + S D +VK+W+ N Y TL
Sbjct: 223 ILIWEAQSCQHLYTFTG-HRDA-VSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYV-ETL 279
Query: 230 NVGQDGAVDISQILILKKKILVTGWERAITVFRPQNFNQFFIQPEEWKGGIQHHDDILCA 289
QD ++ + L ++ VT R TV + I E H I C
Sbjct: 280 FGHQDA---VAALDALSRECCVTAGGRDGTV------RVWKIPEESQLVFYGHQGSIDCI 330
Query: 290 AFLPPQTLVTGSYDGEIVLWNNS 312
+ + +V+G+ DG + LW S
Sbjct: 331 HLINEEHMVSGADDGSVALWGLS 353
Score = 34.7 bits (78), Expect = 0.31
Identities = 54/262 (20%), Positives = 107/262 (40%), Gaps = 31/262 (11%)
Query: 73 ERKQLFSFSKDKVLRLWDIQHQLSIQRIACSFPKSQDFRCLFHFDEAHGRL---FISFNN 129
E ++L +++K LRL +L ++++ + + R F D+ GRL +
Sbjct: 67 EEEELEETAQEKKLRL----AKLYLEQLRQQEEEKAEARA-FEEDQVAGRLKEDVLEQRG 121
Query: 130 QLALLAMK-----SEASKRV-KSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKI 183
+L L K + A RV + H+ ++TC++ + S+ ++ W +++G+K+
Sbjct: 122 RLQKLVAKEIQAPASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKL 181
Query: 184 ----KQFTGCHG-----NAEISTMALDANETRLLTGSTDGTVKIWDFNGYCHHTLNVGQD 234
+ G G ++ + MA+ ++ L +G + IW+ H G
Sbjct: 182 HVIPRAKKGAEGKPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHR 241
Query: 235 GAVDISQILILKKKILVTGWERAITVFRPQNFNQFFIQPEEWKGGIQHHDDILCAAFLPP 294
AV ++ T +R++ V+ N + E G H D + L
Sbjct: 242 DAVSGLAFRRGTHQLYSTSHDRSVKVWNVAE-NSYV---ETLFG---HQDAVAALDALSR 294
Query: 295 QTLVT-GSYDGEIVLWNNSTEN 315
+ VT G DG + +W E+
Sbjct: 295 ECCVTAGGRDGTVRVWKIPEES 316
Score = 30.0 bits (66), Expect = 7.6
Identities = 35/174 (20%), Positives = 69/174 (39%), Gaps = 23/174 (13%)
Query: 60 GHSASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRI-----ACSFPKSQDFRCLF 114
GH +V + F QL+S S D+ +++W++ ++ + A + + C
Sbjct: 239 GHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCV 298
Query: 115 HFDEAHGRLFISFNNQLALLAMKSEASKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSF 174
A GR + + + + E+ H+ ++ C+ + V +D GS V+
Sbjct: 299 ---TAGGR-----DGTVRVWKIPEESQLVFYGHQGSIDCIHLINEEHMVSGADDGS-VAL 349
Query: 175 WMIDTGQKIKQFTGCHGNAE---------ISTMALDANETRLLTGSTDGTVKIW 219
W + + + HG IS++A N + TGS V++W
Sbjct: 350 WGLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLW 403
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 48.9 bits (115), Expect = 2e-05
Identities = 71/318 (22%), Positives = 125/318 (39%), Gaps = 48/318 (15%)
Query: 41 NKVCLWNPYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQ------ 94
NK+ LWN SK V GH + V V F + + S D+ +RLW+ +
Sbjct: 819 NKIFLWNTDSRSK-VADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAV 877
Query: 95 LSIQRIACSFPKSQ-------DFRCLFHFDEAHGRL------------------FISFNN 129
+ Q + F +++ R L + G++ +I+F +
Sbjct: 878 MLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGD 937
Query: 130 QLALLAMKSEASKRVKS----HEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQ 185
+ + + + R+ H+K V + + + K +ISS + + W ++ +
Sbjct: 938 ENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVW----NWQLDK 993
Query: 186 FTGCHGNAEISTMALDANETRLLTGSTDGTVKIWDFNGYCHHTLNVGQDGAVDISQILIL 245
G+ E +RLL+ S DGTVK+W+ V G V I
Sbjct: 994 CIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHD 1053
Query: 246 KKKILVTGWERAITVFRPQNFNQFFIQPEEWKGGIQHHDDILCAAFLPPQTLV-TGSYDG 304
K T ++ ++ +F+ + E +G H+ + C+AF TL+ TG +G
Sbjct: 1054 ATKFSSTSADKTAKIW---SFD-LLLPLHELRG---HNGCVRCSAFSVDSTLLATGDDNG 1106
Query: 305 EIVLWNNSTENAHHVLHP 322
EI +WN S H+ P
Sbjct: 1107 EIRIWNVSNGELLHLCAP 1124
Score = 38.9 bits (89), Expect = 0.016
Identities = 25/113 (22%), Positives = 47/113 (41%), Gaps = 4/113 (3%)
Query: 121 GRLFISFNNQLALLAMKSEASKR---VKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMI 177
G+ S L K+E ++ +K+HE V C +++ + + + V W
Sbjct: 627 GQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNS 686
Query: 178 DTGQKIKQFTGCHGNAEISTMALDANETRLLTGSTDGTVKIWDFN-GYCHHTL 229
TG+ + + ++ L TGS+D +K+WD N C +T+
Sbjct: 687 MTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTM 739
Score = 36.2 bits (82), Expect = 0.11
Identities = 99/525 (18%), Positives = 195/525 (37%), Gaps = 101/525 (19%)
Query: 9 KRLNMTSFNIAQGIHAFDYHS-RLN-----------LIATAGINNKVCLWNPYVVSKPVG 56
K++ + + + +H +D HS ++N L+AT + + LW+ +
Sbjct: 679 KKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD-LNQKECRN 737
Query: 57 VLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDI-----QHQLSIQRIACSFPKSQDFR 111
++GH+ SV +F + K L S S D L+LWD + +++++ + Q+
Sbjct: 738 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM 797
Query: 112 ------CLFHFDEAHGRLFISFNNQLALLAMKSEAS-KRVKSHEKAVTCVLYNSILKQVI 164
C + D A R+ ++ N++ L S + + H V V+++ +
Sbjct: 798 EVIVKCCSWSADGA--RIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFL 855
Query: 165 SSDTGSTVSFWMI-----DTGQKIKQFTG-CHGNAEISTMALD-ANETRLLTGS------ 211
+S T+ W ++ +KQ E+ +A+D +L+ G
Sbjct: 856 TSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDY 915
Query: 212 -TDGTVKIWDFNGYCHHTLNVGQDGAVDISQILILKKKILVTGWERAITVFRPQ------ 264
T+ V + + + ++GA++I + ++ +I + ++ TV+ Q
Sbjct: 916 LTEAQVSCCCLSPHLQYIAFGDENGAIEILE--LVNNRIFQSRFQHKKTVWHIQFTADEK 973
Query: 265 ----NFNQFFIQPEEWKGG-----IQHHDDILCAAFLPPQTLVTGSYDGEIVLWNNSTEN 315
+ + IQ W+ H + + L L++ S+DG + +WN T N
Sbjct: 974 TLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGN 1033
Query: 316 AH--HVLHP----------DYQRLLKSKLDTKPQKLLSAGRSQPSHPMADHS-------- 355
V H D + + D K K+ S P H + H+
Sbjct: 1034 KEKDFVCHQGTVLSCDISHDATKFSSTSAD-KTAKIWSFDLLLPLHELRGHNGCVRCSAF 1092
Query: 356 -------TTGVRNFEID--TEGKNAVMRLCFLKARKNTAVTG-----------GANLVSC 395
TG N EI ++ LC + + A G G L+S
Sbjct: 1093 SVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISA 1152
Query: 396 GGSGYVRFWDIYKKQLLAEFLAHSGVGSIIMSTDKMNRYLTTGDL 440
G GY+++W++ + F + I + Y+T +L
Sbjct: 1153 G--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNL 1195
Score = 30.0 bits (66), Expect = 7.6
Identities = 30/126 (23%), Positives = 48/126 (38%), Gaps = 12/126 (9%)
Query: 282 HHDDILCAAFLPPQTLV-TGSYDGEIVLWNNSTENAHHVLHPDYQRLLKSKL-DTKPQKL 339
H D++LC AF + T S D ++ +WN+ T H +++ ++ L
Sbjct: 656 HEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLL 715
Query: 340 LSAGRSQPSHPMADHSTTGVRNFEIDTEGKNAVMRLCFLKARKNTAVTGGANLVSCGGSG 399
L+ G S + D + RN N+V F K L SC G
Sbjct: 716 LATGSSDCFLKLWDLNQKECRNTMFG--HTNSVNHCRFSPDDK--------LLASCSADG 765
Query: 400 YVRFWD 405
++ WD
Sbjct: 766 TLKLWD 771
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 48.9 bits (115), Expect = 2e-05
Identities = 71/318 (22%), Positives = 125/318 (39%), Gaps = 48/318 (15%)
Query: 41 NKVCLWNPYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQ------ 94
NK+ LWN SK V GH + V V F + + S D+ +RLW+ +
Sbjct: 808 NKIFLWNTDSRSK-VADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAV 866
Query: 95 LSIQRIACSFPKSQ-------DFRCLFHFDEAHGRL------------------FISFNN 129
+ Q + F +++ R L + G++ +I+F +
Sbjct: 867 MLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGD 926
Query: 130 QLALLAMKSEASKRVKS----HEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQ 185
+ + + + R+ H+K V + + + K +ISS + + W ++ +
Sbjct: 927 ENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVW----NWQLDK 982
Query: 186 FTGCHGNAEISTMALDANETRLLTGSTDGTVKIWDFNGYCHHTLNVGQDGAVDISQILIL 245
G+ E +RLL+ S DGTVK+W+ V G V I
Sbjct: 983 CIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHD 1042
Query: 246 KKKILVTGWERAITVFRPQNFNQFFIQPEEWKGGIQHHDDILCAAFLPPQTLV-TGSYDG 304
K T ++ ++ +F+ + E +G H+ + C+AF TL+ TG +G
Sbjct: 1043 ATKFSSTSADKTAKIW---SFD-LLLPLHELRG---HNGCVRCSAFSVDSTLLATGDDNG 1095
Query: 305 EIVLWNNSTENAHHVLHP 322
EI +WN S H+ P
Sbjct: 1096 EIRIWNVSNGELLHLCAP 1113
Score = 38.9 bits (89), Expect = 0.016
Identities = 25/113 (22%), Positives = 47/113 (41%), Gaps = 4/113 (3%)
Query: 121 GRLFISFNNQLALLAMKSEASKR---VKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMI 177
G+ S L K+E ++ +K+HE V C +++ + + + V W
Sbjct: 616 GQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNS 675
Query: 178 DTGQKIKQFTGCHGNAEISTMALDANETRLLTGSTDGTVKIWDFN-GYCHHTL 229
TG+ + + ++ L TGS+D +K+WD N C +T+
Sbjct: 676 MTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTM 728
Score = 36.2 bits (82), Expect = 0.11
Identities = 99/525 (18%), Positives = 195/525 (37%), Gaps = 101/525 (19%)
Query: 9 KRLNMTSFNIAQGIHAFDYHS-RLN-----------LIATAGINNKVCLWNPYVVSKPVG 56
K++ + + + +H +D HS ++N L+AT + + LW+ +
Sbjct: 668 KKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD-LNQKECRN 726
Query: 57 VLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDI-----QHQLSIQRIACSFPKSQDFR 111
++GH+ SV +F + K L S S D L+LWD + +++++ + Q+
Sbjct: 727 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM 786
Query: 112 ------CLFHFDEAHGRLFISFNNQLALLAMKSEAS-KRVKSHEKAVTCVLYNSILKQVI 164
C + D A R+ ++ N++ L S + + H V V+++ +
Sbjct: 787 EVIVKCCSWSADGA--RIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFL 844
Query: 165 SSDTGSTVSFWMI-----DTGQKIKQFTG-CHGNAEISTMALD-ANETRLLTGS------ 211
+S T+ W ++ +KQ E+ +A+D +L+ G
Sbjct: 845 TSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDY 904
Query: 212 -TDGTVKIWDFNGYCHHTLNVGQDGAVDISQILILKKKILVTGWERAITVFRPQ------ 264
T+ V + + + ++GA++I + ++ +I + ++ TV+ Q
Sbjct: 905 LTEAQVSCCCLSPHLQYIAFGDENGAIEILE--LVNNRIFQSRFQHKKTVWHIQFTADEK 962
Query: 265 ----NFNQFFIQPEEWKGG-----IQHHDDILCAAFLPPQTLVTGSYDGEIVLWNNSTEN 315
+ + IQ W+ H + + L L++ S+DG + +WN T N
Sbjct: 963 TLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGN 1022
Query: 316 AH--HVLHP----------DYQRLLKSKLDTKPQKLLSAGRSQPSHPMADHS-------- 355
V H D + + D K K+ S P H + H+
Sbjct: 1023 KEKDFVCHQGTVLSCDISHDATKFSSTSAD-KTAKIWSFDLLLPLHELRGHNGCVRCSAF 1081
Query: 356 -------TTGVRNFEID--TEGKNAVMRLCFLKARKNTAVTG-----------GANLVSC 395
TG N EI ++ LC + + A G G L+S
Sbjct: 1082 SVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISA 1141
Query: 396 GGSGYVRFWDIYKKQLLAEFLAHSGVGSIIMSTDKMNRYLTTGDL 440
G GY+++W++ + F + I + Y+T +L
Sbjct: 1142 G--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNL 1184
Score = 30.0 bits (66), Expect = 7.6
Identities = 30/126 (23%), Positives = 48/126 (38%), Gaps = 12/126 (9%)
Query: 282 HHDDILCAAFLPPQTLV-TGSYDGEIVLWNNSTENAHHVLHPDYQRLLKSKL-DTKPQKL 339
H D++LC AF + T S D ++ +WN+ T H +++ ++ L
Sbjct: 645 HEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLL 704
Query: 340 LSAGRSQPSHPMADHSTTGVRNFEIDTEGKNAVMRLCFLKARKNTAVTGGANLVSCGGSG 399
L+ G S + D + RN N+V F K L SC G
Sbjct: 705 LATGSSDCFLKLWDLNQKECRNTMFG--HTNSVNHCRFSPDDK--------LLASCSADG 754
Query: 400 YVRFWD 405
++ WD
Sbjct: 755 TLKLWD 760
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,996,720
Number of Sequences: 37866
Number of extensions: 1224438
Number of successful extensions: 4962
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 84
Number of HSP's successfully gapped in prelim test: 122
Number of HSP's that attempted gapping in prelim test: 3505
Number of HSP's gapped (non-prelim): 1118
length of query: 697
length of database: 18,247,518
effective HSP length: 109
effective length of query: 588
effective length of database: 14,120,124
effective search space: 8302632912
effective search space used: 8302632912
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.