Guide to the Human Genome
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Search of human proteins with 29789090

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|29789090 regulator of chromosome condensation 2 [Homo
sapiens]
         (522 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|209969703 regulator of chromosome condensation 2 [Homo sapiens]   1070   0.0  
gi|29789090 regulator of chromosome condensation 2 [Homo sapiens]    1070   0.0  
gi|126032348 hect domain and RLD 2 [Homo sapiens]                     130   2e-30
gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]   130   3e-30
gi|7657152 hect domain and RLD 3 [Homo sapiens]                       124   2e-28
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]            120   4e-27
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]            120   4e-27
gi|4557445 regulator of chromosome condensation and BTB domain c...   118   1e-26
gi|57242759 regulator of chromosome condensation (RCC1) and BTB ...   113   4e-25
gi|110825982 hect domain and RLD 5 [Homo sapiens]                     111   1e-24
gi|61563742 hect domain and RLD 6 [Homo sapiens]                      106   6e-23
gi|114796646 regulator of chromosome condensation 1 isoform b [H...   104   2e-22
gi|114796644 regulator of chromosome condensation 1 isoform a [H...   104   2e-22
gi|4502801 regulator of chromosome condensation 1 isoform c [Hom...   104   2e-22
gi|114796642 regulator of chromosome condensation 1 [Homo sapiens]    104   2e-22
gi|114796640 regulator of chromosome condensation 1 [Homo sapiens]    104   2e-22
gi|114796648 regulator of chromosome condensation 1 [Homo sapiens]    104   2e-22
gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo...    97   3e-20
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    97   3e-20
gi|222136641 NIMA-related kinase 9 [Homo sapiens]                      93   5e-19
gi|30039692 NIMA-related kinase 8 [Homo sapiens]                       91   3e-18
gi|6912330 deafness locus associated putative guanine nucleotide...    90   4e-18
gi|63054860 RCC1 domain containing 1 [Homo sapiens]                    89   7e-18
gi|63054858 RCC1 domain containing 1 [Homo sapiens]                    89   7e-18
gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo ...    79   8e-15
gi|57863304 inhibitor of Bruton's tyrosine kinase [Homo sapiens]       79   8e-15
gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo ...    77   5e-14
gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo s...    76   9e-14
gi|40316935 alsin isoform 1 [Homo sapiens]                             72   9e-13
gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo s...    72   1e-12

>gi|209969703 regulator of chromosome condensation 2 [Homo sapiens]
          Length = 522

 Score = 1070 bits (2767), Expect = 0.0
 Identities = 522/522 (100%), Positives = 522/522 (100%)

Query: 1   MPRKKAAAAAWEEPSSGNGTARAGPRKRGGPAGRKRERPERCSSSSGGGSSGDEDGLELD 60
           MPRKKAAAAAWEEPSSGNGTARAGPRKRGGPAGRKRERPERCSSSSGGGSSGDEDGLELD
Sbjct: 1   MPRKKAAAAAWEEPSSGNGTARAGPRKRGGPAGRKRERPERCSSSSGGGSSGDEDGLELD 60

Query: 61  GAPGGGKRAARPATAGKAGGAAVVITEPEHTKERVKLEGSKCKGQLLIFGATNWDLIGRK 120
           GAPGGGKRAARPATAGKAGGAAVVITEPEHTKERVKLEGSKCKGQLLIFGATNWDLIGRK
Sbjct: 61  GAPGGGKRAARPATAGKAGGAAVVITEPEHTKERVKLEGSKCKGQLLIFGATNWDLIGRK 120

Query: 121 EVPKQQAAYRNLGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKG 180
           EVPKQQAAYRNLGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKG
Sbjct: 121 EVPKQQAAYRNLGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKG 180

Query: 181 QLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQT 240
           QLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQT
Sbjct: 181 QLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQT 240

Query: 241 DAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQR 300
           DAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQR
Sbjct: 241 DAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQR 300

Query: 301 IEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYG 360
           IEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYG
Sbjct: 301 IEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYG 360

Query: 361 RLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSRESTMY 420
           RLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSRESTMY
Sbjct: 361 RLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSRESTMY 420

Query: 421 PKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKT 480
           PKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKT
Sbjct: 421 PKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKT 480

Query: 481 LDGIFSEQVAMGYSHSLVIARDESETEKEKIKKLPEYNPRTL 522
           LDGIFSEQVAMGYSHSLVIARDESETEKEKIKKLPEYNPRTL
Sbjct: 481 LDGIFSEQVAMGYSHSLVIARDESETEKEKIKKLPEYNPRTL 522


>gi|29789090 regulator of chromosome condensation 2 [Homo sapiens]
          Length = 522

 Score = 1070 bits (2767), Expect = 0.0
 Identities = 522/522 (100%), Positives = 522/522 (100%)

Query: 1   MPRKKAAAAAWEEPSSGNGTARAGPRKRGGPAGRKRERPERCSSSSGGGSSGDEDGLELD 60
           MPRKKAAAAAWEEPSSGNGTARAGPRKRGGPAGRKRERPERCSSSSGGGSSGDEDGLELD
Sbjct: 1   MPRKKAAAAAWEEPSSGNGTARAGPRKRGGPAGRKRERPERCSSSSGGGSSGDEDGLELD 60

Query: 61  GAPGGGKRAARPATAGKAGGAAVVITEPEHTKERVKLEGSKCKGQLLIFGATNWDLIGRK 120
           GAPGGGKRAARPATAGKAGGAAVVITEPEHTKERVKLEGSKCKGQLLIFGATNWDLIGRK
Sbjct: 61  GAPGGGKRAARPATAGKAGGAAVVITEPEHTKERVKLEGSKCKGQLLIFGATNWDLIGRK 120

Query: 121 EVPKQQAAYRNLGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKG 180
           EVPKQQAAYRNLGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKG
Sbjct: 121 EVPKQQAAYRNLGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKG 180

Query: 181 QLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQT 240
           QLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQT
Sbjct: 181 QLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQT 240

Query: 241 DAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQR 300
           DAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQR
Sbjct: 241 DAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQR 300

Query: 301 IEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYG 360
           IEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYG
Sbjct: 301 IEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYG 360

Query: 361 RLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSRESTMY 420
           RLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSRESTMY
Sbjct: 361 RLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSRESTMY 420

Query: 421 PKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKT 480
           PKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKT
Sbjct: 421 PKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKT 480

Query: 481 LDGIFSEQVAMGYSHSLVIARDESETEKEKIKKLPEYNPRTL 522
           LDGIFSEQVAMGYSHSLVIARDESETEKEKIKKLPEYNPRTL
Sbjct: 481 LDGIFSEQVAMGYSHSLVIARDESETEKEKIKKLPEYNPRTL 522


>gi|126032348 hect domain and RLD 2 [Homo sapiens]
          Length = 4834

 Score =  130 bits (328), Expect = 2e-30
 Identities = 109/409 (26%), Positives = 185/409 (45%), Gaps = 56/409 (13%)

Query: 137  WGPHRYGCLAGVR-VRTVVSGSCAAHSLL--------------ITTEGKLWSWGRNEKGQ 181
            WG +  G L G+   +  V   C A + L              +T +GKL++ G    G+
Sbjct: 3957 WGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGAGGR 4016

Query: 182  LGHGDTKRVEAPRLIEGLSHEVI--VSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQ 239
            LG G T+ V  P L+E + H  I  V+   G  H LAL+  G V+++GE + G+LG GN+
Sbjct: 4017 LGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNR 4076

Query: 240  TDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQ 299
            +            G  +  +A G   S  +   G+LY++G   YG+LGH+          
Sbjct: 4077 SPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHS---------- 4126

Query: 300  RIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGAN--HTLVLDSQKRVFSWGFG 357
              + + +L P+     +E  +  +++        D+ACG+    TL L     V+SWG G
Sbjct: 4127 --DSEDQLKPK----LVEALQGHRVV--------DIACGSGDAQTLCLTDDDTVWSWGDG 4172

Query: 358  GYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR-- 415
             YG+LG        VP  +K+    G G  ++  G   S A+++ G ++ WG  +  R  
Sbjct: 4173 DYGKLGRGGSDGCKVP--MKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLG 4230

Query: 416  ----ESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTI-SWGPSPTFGELGYGDHKPK 470
                +    P+ VQ L G ++ ++A G    +   ++  + +WG +   G+L  GD    
Sbjct: 4231 HGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDE-GQL--GDGTTN 4287

Query: 471  SSTAAQEVKTLDGIFSEQVAMGYSHSLVIARDESETEKEKIKKLP-EYN 518
            +    + V  L G    +VA G +H+L  +  +  +  +   ++P EYN
Sbjct: 4288 AIQRPRLVAALQGKKVNRVACGSAHTLAWSTSKPASAGKLPAQVPMEYN 4336



 Score =  124 bits (310), Expect = 3e-28
 Identities = 87/311 (27%), Positives = 148/311 (47%), Gaps = 36/311 (11%)

Query: 139  PHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEG 198
            P +   L+   V+ V   S   H+  +T +GK++SWG  + G+LGH      + PRLIE 
Sbjct: 3036 PRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEA 3095

Query: 199  LSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITK 258
            L  + I   ACG +H+ ALT +G ++ +G  + G+LG G+ T  +      +  G  + +
Sbjct: 3096 LKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQ 3155

Query: 259  MACGAE--FSMIMDCKGNLYSFGCPEYGQLGH-NSDGKFIARAQRIEYDCELVPRRVAIF 315
            +ACG+    ++ +  +G ++S+G  ++G+LG   S+G            C  +P+ +   
Sbjct: 3156 VACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEG------------CN-IPQNI--- 3199

Query: 316  IEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRL 375
              +  +GQ        V  + CGA  +L L     V++WG G Y RLGH        P++
Sbjct: 3200 --ERLNGQ-------GVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQV 3250

Query: 376  VKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSRES------TMYPKAVQDLCG 429
            V+     G+    +  G     AV++ G ++ WG  +  ++          P  VQ L G
Sbjct: 3251 VE--GLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEG 3308

Query: 430  WRIRSLACGKS 440
             +I  +ACG S
Sbjct: 3309 QKITRVACGSS 3319



 Score =  123 bits (309), Expect = 4e-28
 Identities = 100/348 (28%), Positives = 156/348 (44%), Gaps = 45/348 (12%)

Query: 166  TTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFA 225
            T   K++ WG N+K QLG     +++ P   E LS   +V  A G     A+T  G V+A
Sbjct: 2956 TIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYA 3015

Query: 226  FGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMAC---GAEFSMIMDCKGNLYSFGCPE 282
             GE   G+LGLG  +  VP P QI      + K      G   +  +   G ++S+G  +
Sbjct: 3016 CGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGD 3075

Query: 283  YGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHT 342
             G+LGH S             +C+  PR +     KTK           +RD+ACG++H+
Sbjct: 3076 DGKLGHFS-----------RMNCD-KPRLIEAL--KTKR----------IRDIACGSSHS 3111

Query: 343  LVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGY--TCSFAVS 400
              L S   +++WG G YGRLGH +   ++ P++VK+    G    Q+  G     + A++
Sbjct: 3112 AALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKV--LLGHRVIQVACGSRDAQTLALT 3169

Query: 401  EVGGLFFWGATNTSR------ESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTI-SW 453
            + G +F WG  +  +      E    P+ ++ L G  +  + CG    +       + +W
Sbjct: 3170 DEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTW 3229

Query: 454  GPSPTFGELGYGD--HKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVI 499
            G    F  LG+G   H  K     Q V+ L G     VA+G  H L +
Sbjct: 3230 GKGDYF-RLGHGSDVHVRK----PQVVEGLRGKKIVHVAVGALHCLAV 3272



 Score =  117 bits (293), Expect = 3e-26
 Identities = 106/369 (28%), Positives = 167/369 (45%), Gaps = 51/369 (13%)

Query: 145  LAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHG-DTKRVEAPRLIEGLSHEV 203
            L+ + V  V  GS +  +  +T EGK+++ G    G+LG G  +  V  PR I  LS  V
Sbjct: 2989 LSALNVVQVAGGSKSLFA--VTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYV 3046

Query: 204  I--VSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMAC 261
            +  V+   G  H  ALT  G VF++GE   G+LG  ++ +            + I  +AC
Sbjct: 3047 VKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIAC 3106

Query: 262  GAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKD 321
            G+  S  +   G LY++G  EYG+LGH  +              +L P+ V + +     
Sbjct: 3107 GSSHSAALTSSGELYTWGLGEYGRLGHGDN------------TTQLKPKMVKVLLGHR-- 3152

Query: 322  GQILPVPNVVVRDVACGAN--HTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLF 379
                      V  VACG+    TL L  +  VFSWG G +G+LG    +   +P+ ++  
Sbjct: 3153 ----------VIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERL 3202

Query: 380  DFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR------ESTMYPKAVQDLCGWRIR 433
            +  G+G  QI  G   S A+++ G ++ WG  +  R           P+ V+ L G +I 
Sbjct: 3203 N--GQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIV 3260

Query: 434  SLACGKSSIIVAADESTI-SWGPSPTFGELGYG----DHKPKSSTAAQEVKTLDGIFSEQ 488
             +A G    +   D   + +WG +   G+ G G    + KP        V+ L+G    +
Sbjct: 3261 HVAVGALHCLAVTDSGQVYAWGDN-DHGQQGNGTTTVNRKPTL------VQGLEGQKITR 3313

Query: 489  VAMGYSHSL 497
            VA G SHS+
Sbjct: 3314 VACGSSHSV 3322



 Score =  116 bits (291), Expect = 4e-26
 Identities = 98/370 (26%), Positives = 172/370 (46%), Gaps = 54/370 (14%)

Query: 139  PHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEG 198
            P     L   R+R +  GS  +HS  +T+ G+L++WG  E G+LGHGD      P++++ 
Sbjct: 3090 PRLIEALKTKRIRDIACGS--SHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKV 3147

Query: 199  LSHEVIVSAACGRN--HTLALTETGSVFAFGENKMGQLGLGNQTDA-VPSPAQIMYNGQP 255
            L    ++  ACG     TLALT+ G VF++G+   G+LG G      +P   + + NGQ 
Sbjct: 3148 LLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERL-NGQG 3206

Query: 256  ITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIF 315
            + ++ CGA+FS+ +   G ++++G  +Y +LGH SD                      + 
Sbjct: 3207 VCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSD----------------------VH 3244

Query: 316  IEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRL 375
            + K +  + L    +V   VA GA H L +    +V++WG   +G+ G+        P L
Sbjct: 3245 VRKPQVVEGLRGKKIV--HVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTL 3302

Query: 376  VKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSRESTMYPKAVQDLCGWRIRSL 435
            V+     G+  +++  G + S A + V       AT +  E  ++  A   L        
Sbjct: 3303 VQ--GLEGQKITRVACGSSHSVAWTTVD-----VATPSVHEPVLFQTARDPL-------- 3347

Query: 436  ACGKSSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGY-- 493
              G S + V +D  + +     +    G  + KP   + A+ + +LDG  ++Q A+ +  
Sbjct: 3348 --GASYLGVPSDADSSAASNKIS----GASNSKPNRPSLAKILLSLDGNLAKQQALSHIL 3401

Query: 494  -SHSLVIARD 502
             +  ++ ARD
Sbjct: 3402 TALQIMYARD 3411



 Score =  114 bits (285), Expect = 2e-25
 Identities = 85/307 (27%), Positives = 143/307 (46%), Gaps = 40/307 (13%)

Query: 145 LAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEV- 203
           LA   +  + + S   H L +   G+++SWG  + G+LGHGDT  +E P++I   S +  
Sbjct: 490 LASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQA 549

Query: 204 ---IVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMA 260
              +V  ACG  ++ A+T  G ++ +G    G+LG G+  D           G  +  +A
Sbjct: 550 GKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVA 609

Query: 261 CGA--EFSMIMDCKGNLYSFGCPEYGQLGH-NSDGKFIARAQRIEYDCELVPRRVAIFIE 317
           CG+    ++ +   G ++S+G  +YG+LG   SDG            C+  P+     IE
Sbjct: 610 CGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDG------------CK-TPK----LIE 652

Query: 318 KTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVK 377
           K +D  ++         V CG+  ++ L    +V+SWG G   RLGH  ++    P+L++
Sbjct: 653 KLQDLDVV--------KVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLE 704

Query: 378 LFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGAT------NTSRESTMYPKAVQDLCGWR 431
                G+    + AG T   A++E   +  WG+       +T R +   P A+  L    
Sbjct: 705 --GLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPAALPGLDTKH 762

Query: 432 IRSLACG 438
           I  +ACG
Sbjct: 763 IVGIACG 769



 Score =  102 bits (253), Expect = 1e-21
 Identities = 69/216 (31%), Positives = 105/216 (48%), Gaps = 30/216 (13%)

Query: 143 GCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHE 202
           G  AG  V  +  GS   +S  IT EG+L++WGR   G+LGHG ++    P L+ GL   
Sbjct: 546 GKQAGKHVVHIACGS--TYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGL 603

Query: 203 VIVSAACGRN--HTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQI-MYNGQPITKM 259
            ++  ACG     TLA+TE G V+++G+   G+LG G  +D   +P  I       + K+
Sbjct: 604 KVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGG-SDGCKTPKLIEKLQDLDVVKV 662

Query: 260 ACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKT 319
            CG++FS+ +   G +YS+G  +  +LGH ++       + + Y              K 
Sbjct: 663 RCGSQFSIALTKDGQVYSWGKGDNQRLGHGTE-------EHVRY-------------PKL 702

Query: 320 KDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWG 355
            +G    +    V DVA G+ H L L     V SWG
Sbjct: 703 LEG----LQGKKVIDVAAGSTHCLALTEDSEVHSWG 734



 Score = 85.9 bits (211), Expect = 8e-17
 Identities = 84/343 (24%), Positives = 140/343 (40%), Gaps = 64/343 (18%)

Query: 180 GQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQ 239
           G +G      V  P   EGL++  +   AC     L L+  G V+    N          
Sbjct: 429 GLIGWKYYANVIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYN---------- 478

Query: 240 TDAVPSPAQIMYNGQPITKMACGAE--FSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIAR 297
           +D +          + I K+A  ++    + +   G +YS+GC + G+LGH   G  +  
Sbjct: 479 SDTLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGH---GDTVPL 535

Query: 298 AQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFG 357
            +         P+ ++ F  K     ++         +ACG+ ++  + ++  +++WG G
Sbjct: 536 EE---------PKVISAFSGKQAGKHVV--------HIACGSTYSAAITAEGELYTWGRG 578

Query: 358 GYGRLGHAEQKDEMVPRLV------KLFDFP-GRGASQIYAGYTCSFAVSEVGGLFFWGA 410
            YGRLGH   +DE +P LV      K+ D   G G +Q       + AV+E G ++ WG 
Sbjct: 579 NYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQ-------TLAVTENGQVWSWGD 631

Query: 411 TNTSR------ESTMYPKAVQDLCGWRIRSLACGKS-SIIVAADESTISWGPSPTFGELG 463
            +  +      +    PK ++ L    +  + CG   SI +  D    SWG       LG
Sbjct: 632 GDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDN-QRLG 690

Query: 464 YGDHK----PKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARD 502
           +G  +    PK     Q  K +D      VA G +H L +  D
Sbjct: 691 HGTEEHVRYPKLLEGLQGKKVID------VAAGSTHCLALTED 727



 Score = 82.4 bits (202), Expect = 9e-16
 Identities = 75/298 (25%), Positives = 127/298 (42%), Gaps = 38/298 (12%)

Query: 214  TLALTETGSVFAFGENKMGQL-GLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCK 272
            TL+   +G+++ +G N  GQL G+      VP+P + +   +P+ ++  G +    +   
Sbjct: 3945 TLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPV-QLIGGEQTLFAVTAD 4003

Query: 273  GNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVV 332
            G LY+ G    G+LG       I   + +     L+     +FI+K              
Sbjct: 4004 GKLYATGYGAGGRLG-------IGGTESVSTP-TLLESIQHVFIKKVA------------ 4043

Query: 333  RDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAG 392
              V  G  H L L S+  V+SWG    G+LGH  +     PR+++     G     + AG
Sbjct: 4044 --VNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIE--SLRGIEVVDVAAG 4099

Query: 393  YTCSFAVSEVGGLFFWGATNTSR------ESTMYPKAVQDLCGWRIRSLACGK---SSII 443
               S  V+  G L+ WG     R      E  + PK V+ L G R+  +ACG     ++ 
Sbjct: 4100 GAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLC 4159

Query: 444  VAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIAR 501
            +  D++  SWG    +G+LG G           ++ +L G+   +V  G   S+ + +
Sbjct: 4160 LTDDDTVWSWGDG-DYGKLGRGG--SDGCKVPMKIDSLTGLGVVKVECGSQFSVALTK 4214


>gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]
          Length = 4861

 Score =  130 bits (327), Expect = 3e-30
 Identities = 88/276 (31%), Positives = 131/276 (47%), Gaps = 35/276 (12%)

Query: 148  VRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSA 207
            V  + V S     HS+ +T  G+++SWG  + G+LGHG++ R   PR IE L  E +V  
Sbjct: 4080 VVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQM 4139

Query: 208  ACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSM 267
            +CG  H+  +T  G +F FG    G+LGLGN ++           G  I ++ACG   ++
Sbjct: 4140 SCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTL 4199

Query: 268  IMDCKGNL-YSFGCPEYGQLG-HNSDGKFIARAQRIEYDCELVPRRVA----IFIEKTKD 321
             +   G++ ++FG  +YG+LG  NS  K  +  Q+I+  C +  ++VA      +  TKD
Sbjct: 4200 AVSADGSMVWAFGDGDYGKLGLGNSTAK--SSPQKIDVLCGIGIKKVACGTQFSVALTKD 4257

Query: 322  G-------------------------QILPVPNVVVRDVACGANHTLVLDSQKRVFSWGF 356
            G                         QI  +  V++ DVA GA HTL L S   V++WG 
Sbjct: 4258 GHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGS 4317

Query: 357  GGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAG 392
               G+LG         P LV      G+   QI AG
Sbjct: 4318 NSEGQLGLGHTNHVREPTLVT--GLQGKNVRQISAG 4351



 Score =  125 bits (314), Expect = 9e-29
 Identities = 94/347 (27%), Positives = 165/347 (47%), Gaps = 41/347 (11%)

Query: 162 SLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVI--VSAACGRN-HTLALT 218
           + +I+T+G + + G+   G+LG GD+      + +    H  I  VS++ G + HTLA T
Sbjct: 415 TFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFT 474

Query: 219 ETGSVFAFGENKMGQLGLGNQ-TDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYS 277
             G VF++G+   G+LG GN  T   P   Q    G+ +  ++ G   S  +   G LY+
Sbjct: 475 TEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYT 534

Query: 278 FGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVAC 337
           +G  ++G+LGH                     R +   ++   +          V +V+C
Sbjct: 535 WGEGDFGRLGHGDSNS----------------RNIPTLVKDISN----------VGEVSC 568

Query: 338 GANHTLVLDSQKR-VFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCS 396
           G++HT+ L    R V+S+G G  G+LGH +      P++++     G    ++ AG   S
Sbjct: 569 GSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQ--GMFIRKVCAGSQSS 626

Query: 397 FAVSEVGGLFFWGA-----TNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAA-DEST 450
            A++  G ++ WG        +S  + + PK +++L   RI  ++ G S  +  + D   
Sbjct: 627 LALTSTGQVYAWGCGACLGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEV 686

Query: 451 ISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSL 497
            +WG + + G+ G G+      T  ++V  LDGI  +Q++ G SHSL
Sbjct: 687 YAWGNN-SMGQCGQGN-STGPITKPKKVSGLDGIAIQQISAGTSHSL 731



 Score =  112 bits (279), Expect = 1e-24
 Identities = 107/392 (27%), Positives = 181/392 (46%), Gaps = 68/392 (17%)

Query: 136  LWGPHRYGCLAGVRVRTVVSGSCAAHS------------LLITTEGKLWSWGRNEKGQLG 183
            LWG  R+G LA      +V  +  + S             +I   G + + G    G+LG
Sbjct: 4001 LWGAGRHGQLAEAGRNVMVPAAAPSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLG 4060

Query: 184  HGDTKRVEAPRLIEGLSHEVIVS--AACGRN-HTLALTETGSVFAFGENKMGQLGLGNQT 240
             G++  +    +I  L   V+     +CG + H++ALTE+G VF++G+   G+LG GN +
Sbjct: 4061 QGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGN-S 4119

Query: 241  DAVPSPAQI-MYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQ 299
            D    P QI    G+ + +M+CG + S ++   G L++FG  +YG+LG  +         
Sbjct: 4120 DRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSN------ 4173

Query: 300  RIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQ-KRVFSWGFGG 358
                  + +P RV   +E  + GQ           VACG NHTL + +    V+++G G 
Sbjct: 4174 ------KKLPERVTA-LEGYQIGQ-----------VACGLNHTLAVSADGSMVWAFGDGD 4215

Query: 359  YGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWG--------- 409
            YG+LG      +  P+  K+    G G  ++  G   S A+++ G ++ +G         
Sbjct: 4216 YGKLGLGNSTAKSSPQ--KIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPE 4273

Query: 410  --ATNTSRESTMYPKAVQDLCGWRIRSLACG-KSSIIVAADESTISWGPSPTFGELGYG- 465
              A N +R     P+ +  L G  I  +A G + ++ +A++    +WG S + G+LG G 
Sbjct: 4274 GRARNHNR-----PQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWG-SNSEGQLGLGH 4327

Query: 466  -DHKPKSSTAAQEVKTLDGIFSEQVAMGYSHS 496
             +H  + +     V  L G    Q++ G  HS
Sbjct: 4328 TNHVREPTL----VTGLQGKNVRQISAGRCHS 4355



 Score =  111 bits (277), Expect = 2e-24
 Identities = 95/346 (27%), Positives = 155/346 (44%), Gaps = 53/346 (15%)

Query: 171  LWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENK 230
            ++ WG    GQL     + V  P      S    V   CG+N T  +   G+V A GE  
Sbjct: 3999 VYLWGAGRHGQLAEAG-RNVMVPAAAPSFSQAQQV--ICGQNCTFVIQANGTVLACGEGS 4055

Query: 231  MGQLGLGNQTDAVPSPAQIMYNGQPITKM--ACGAE-FSMIMDCKGNLYSFGCPEYGQLG 287
             G+LG GN  D           G  +T++  +CG++  SM +   G ++S+G  +YG+LG
Sbjct: 4056 YGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLG 4115

Query: 288  H-NSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLD 346
            H NSD     R +R        PR            QI  +    V  ++CG  H+ V+ 
Sbjct: 4116 HGNSD-----RQRR--------PR------------QIEALQGEEVVQMSCGFKHSAVVT 4150

Query: 347  SQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLF 406
            S  ++F++G G YGRLG     ++ +P  V   +  G    Q+  G   + AVS  G + 
Sbjct: 4151 SDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALE--GYQIGQVACGLNHTLAVSADGSMV 4208

Query: 407  F---------WGATNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSP 457
            +          G  N++ +S+  P+ +  LCG  I+ +ACG    +    +  +      
Sbjct: 4209 WAFGDGDYGKLGLGNSTAKSS--PQKIDVLCGIGIKKVACGTQFSVALTKDGHVY----- 4261

Query: 458  TFGE---LGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIA 500
            TFG+   +G  + + ++    Q++  L G+  E VA+G  H+L +A
Sbjct: 4262 TFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALA 4307



 Score =  103 bits (258), Expect = 3e-22
 Identities = 78/307 (25%), Positives = 143/307 (46%), Gaps = 44/307 (14%)

Query: 161 HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEG-LSHEVIVSAACGRNHTLALTE 219
           H+L  TTEG+++SWG  + G+LGHG++   + P+LI+G L  +V+V  + G  H+ A+TE
Sbjct: 469 HTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTE 528

Query: 220 TGSVFAFGENKMGQLGLGNQTDA-VPSPAQIMYNGQPITKMACGAEFSMIMDCKG-NLYS 277
            G ++ +GE   G+LG G+     +P+  + + N   + +++CG+  ++ +   G  ++S
Sbjct: 529 DGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISN---VGEVSCGSSHTIALSKDGRTVWS 585

Query: 278 FGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVAC 337
           FG  + G+LGH    +         Y  +++     +FI K                V  
Sbjct: 586 FGGGDNGKLGHGDTNRV--------YKPKVIEALQGMFIRK----------------VCA 621

Query: 338 GANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSF 397
           G+  +L L S  +V++WG G     G +E    + P+L++  +        +  G +   
Sbjct: 622 GSQSSLALTSTGQVYAWGCGACLGCGSSE-ATALRPKLIE--ELAATRIVDVSIGDSHCL 678

Query: 398 AVSEVGGLFFWG-------ATNTSRESTMYPKAVQDLCGWRIRSLACGKSSII----VAA 446
           A+S    ++ WG           S      PK V  L G  I+ ++ G S  +    +  
Sbjct: 679 ALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLAWTALPR 738

Query: 447 DESTISW 453
           D   ++W
Sbjct: 739 DRQVVAW 745



 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 84/312 (26%), Positives = 134/312 (42%), Gaps = 43/312 (13%)

Query: 202  EVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMAC 261
            E I+S A  R     L     V+ +G  + GQL    +   VP+ A      Q   ++ C
Sbjct: 3978 EQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMVPAAAPSFSQAQ---QVIC 4034

Query: 262  GAEFSMIMDCKGNLYSFGCPEYGQLGH-NSDGKFIARAQRIEYDCELVPRRVAIFIEKTK 320
            G   + ++   G + + G   YG+LG  NSD   +                         
Sbjct: 4035 GQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTV---------------------- 4072

Query: 321  DGQILPVPNVVVRDV--ACGAN-HTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVK 377
               I  +   VV  +  +CG++ H++ L     VFSWG G YG+LGH     +  PR ++
Sbjct: 4073 ---ISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIE 4129

Query: 378  LFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR------ESTMYPKAVQDLCGWR 431
                 G    Q+  G+  S  V+  G LF +G  +  R       +   P+ V  L G++
Sbjct: 4130 ALQ--GEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQ 4187

Query: 432  IRSLACG-KSSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVA 490
            I  +ACG   ++ V+AD S +       +G+LG G+   KSS   Q++  L GI  ++VA
Sbjct: 4188 IGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSS--PQKIDVLCGIGIKKVA 4245

Query: 491  MGYSHSLVIARD 502
             G   S+ + +D
Sbjct: 4246 CGTQFSVALTKD 4257



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 54/205 (26%), Positives = 92/205 (44%), Gaps = 33/205 (16%)

Query: 157 SC-AAHSLLITTEGK-LWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHT 214
           SC ++H++ ++ +G+ +WS+G  + G+LGHGDT RV  P++IE L    I     G   +
Sbjct: 567 SCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSS 626

Query: 215 LALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQI-MYNGQPITKMACGAEFSMIMDCKG 273
           LALT TG V+A+G      LG G+       P  I       I  ++ G    + +    
Sbjct: 627 LALTSTGQVYAWGCGAC--LGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDN 684

Query: 274 NLYSFGCPEYGQLGH-NSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVV 332
            +Y++G    GQ G  NS G                          TK  ++  +  + +
Sbjct: 685 EVYAWGNNSMGQCGQGNSTGPI------------------------TKPKKVSGLDGIAI 720

Query: 333 RDVACGANHTL---VLDSQKRVFSW 354
           + ++ G +H+L    L   ++V +W
Sbjct: 721 QQISAGTSHSLAWTALPRDRQVVAW 745



 Score = 65.9 bits (159), Expect = 9e-11
 Identities = 51/182 (28%), Positives = 84/182 (46%), Gaps = 15/182 (8%)

Query: 333  RDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAG 392
            + V CG N T V+ +   V + G G YGRLG     D  V  ++      G   +Q+   
Sbjct: 4030 QQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQ--GFVVTQLVTS 4087

Query: 393  YTC---SFAVSEVGGLFFWGATNTSR------ESTMYPKAVQDLCGWRIRSLACG-KSSI 442
                  S A++E G +F WG  +  +      +    P+ ++ L G  +  ++CG K S 
Sbjct: 4088 CGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSA 4147

Query: 443  IVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARD 502
            +V +D    ++G +  +G LG G+   K     + V  L+G    QVA G +H+L ++ D
Sbjct: 4148 VVTSDGKLFTFG-NGDYGRLGLGNTSNKK--LPERVTALEGYQIGQVACGLNHTLAVSAD 4204

Query: 503  ES 504
             S
Sbjct: 4205 GS 4206



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 30/80 (37%), Positives = 44/80 (55%), Gaps = 2/80 (2%)

Query: 139  PHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEG 198
            P +   LAGV +  V  G  A H+L + + G +++WG N +GQLG G T  V  P L+ G
Sbjct: 4282 PQQIPVLAGVIIEDVAVG--AEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTG 4339

Query: 199  LSHEVIVSAACGRNHTLALT 218
            L  + +   + GR H+ A T
Sbjct: 4340 LQGKNVRQISAGRCHSAAWT 4359



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 48/181 (26%), Positives = 82/181 (45%), Gaps = 22/181 (12%)

Query: 335 VACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYA--- 391
           +  G   T V+ +   V + G G YGRLG  +  ++    L KL   P R   ++ +   
Sbjct: 408 IEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQST--LKKLTFEPHRSIKKVSSSKG 465

Query: 392 --GYTCSFAVSEVGGLFFWGATNTSR------ESTMYPKAVQ-DLCGWRIRSLACG-KSS 441
             G+T +F     G +F WG  +  +       +  YPK +Q  L G  +  ++ G + S
Sbjct: 466 SDGHTLAFTTE--GEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHS 523

Query: 442 IIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIAR 501
             V  D    +WG    FG LG+GD   ++      VK +  +   +V+ G SH++ +++
Sbjct: 524 AAVTEDGELYTWGEG-DFGRLGHGDSNSRNIPTL--VKDISNV--GEVSCGSSHTIALSK 578

Query: 502 D 502
           D
Sbjct: 579 D 579


>gi|7657152 hect domain and RLD 3 [Homo sapiens]
          Length = 1050

 Score =  124 bits (312), Expect = 2e-28
 Identities = 85/271 (31%), Positives = 129/271 (47%), Gaps = 30/271 (11%)

Query: 139 PHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTK-RVEAPRLIE 197
           P + G LA   +  V  G   +HSL ++  G+L+SWG    GQLG   T+  V  PRLI+
Sbjct: 75  PEQIGALADQHIIHVACGE--SHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQ 132

Query: 198 GLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQI-MYNGQPI 256
            L+ + I+  +CG  H LAL   G  F +G+N  GQLGLG +  +  SP ++    G P+
Sbjct: 133 KLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPL 192

Query: 257 TKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFI 316
            ++A G   S  +   G ++ +G    GQLG       ++  +  E  C +         
Sbjct: 193 AQVAAGGAHSFALSLSGAVFGWGMNNAGQLG-------LSDEKDRESPCHV--------- 236

Query: 317 EKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLV 376
                 ++L    VV   ++CG  HT VL     VF++G G  G+LGH    DE+ PR  
Sbjct: 237 ------KLLRTQKVVY--ISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPR-- 286

Query: 377 KLFDFPGRGASQIYAGYTCSFAVSEVGGLFF 407
           ++ +  G   +QI  G   + A     GL +
Sbjct: 287 RVLELMGSEVTQIACGRQHTLAFVPSSGLIY 317



 Score =  123 bits (309), Expect = 4e-28
 Identities = 100/356 (28%), Positives = 161/356 (45%), Gaps = 50/356 (14%)

Query: 129 YRNLGQ-----NLWG----PHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEK 179
           Y +LGQ     NL G    P   G ++   V+ V  G    HS+ +  +G++++ G N K
Sbjct: 6   YWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGG--NHSVFLLEDGEVYTCGLNTK 63

Query: 180 GQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQ 239
           GQLGH   +    P  I  L+ + I+  ACG +H+LAL++ G +F++G    GQLGL   
Sbjct: 64  GQLGH--EREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTT 121

Query: 240 TDAVPSPAQIM-YNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARA 298
            D+V  P  I   N Q I +++CG    + +   G  +++G   +GQLG           
Sbjct: 122 EDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGK-------- 173

Query: 299 QRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGG 358
              E+  +  P+RV              +  + +  VA G  H+  L     VF WG   
Sbjct: 174 ---EFPSQASPQRVR------------SLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNN 218

Query: 359 YGRLGHAEQKDEMVPRLVKLFDFPGRGASQIY--AGYTCSFAVSEVGGLFFWGA------ 410
            G+LG +++KD   P  VKL     R    +Y   G   +  +++ GG+F +GA      
Sbjct: 219 AGQLGLSDEKDRESPCHVKLL----RTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQL 274

Query: 411 TNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTISWG-PSPTFGELGYG 465
            + S    + P+ V +L G  +  +ACG+   +     S + +       G+LG G
Sbjct: 275 GHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTG 330



 Score =  102 bits (255), Expect = 7e-22
 Identities = 62/186 (33%), Positives = 92/186 (49%), Gaps = 15/186 (8%)

Query: 104 GQLLIFGATNWDLIGR-KEVPKQQAAYRNLGQNLWGPHRYGCLAGVRVRTVVSGSCAAHS 162
           GQ   +G  +   +G  KE P Q +           P R   L G+ +  V +G   AHS
Sbjct: 156 GQFFTWGKNSHGQLGLGKEFPSQAS-----------PQRVRSLEGIPLAQVAAGG--AHS 202

Query: 163 LLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGS 222
             ++  G ++ WG N  GQLG  D K  E+P  ++ L  + +V  +CG  HT  LT++G 
Sbjct: 203 FALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGG 262

Query: 223 VFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSM-IMDCKGNLYSFGCP 281
           VF FG    GQLG  +  D V     +   G  +T++ACG + ++  +   G +Y+FGC 
Sbjct: 263 VFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCG 322

Query: 282 EYGQLG 287
             GQLG
Sbjct: 323 ARGQLG 328



 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 57/179 (31%), Positives = 91/179 (50%), Gaps = 18/179 (10%)

Query: 332 VRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQ--KDEMVPRLVKLFDFPGRGASQI 389
           V++VACG NH++ L     V++ G    G+LGH  +  K E +  L        +    +
Sbjct: 36  VKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQIGALAD------QHIIHV 89

Query: 390 YAGYTCSFAVSEVGGLFFWGATN-------TSRESTMYPKAVQDLCGWRIRSLACGK-SS 441
             G + S A+S+ G LF WGA +       T+ +S   P+ +Q L    I  ++CG    
Sbjct: 90  ACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHC 149

Query: 442 IIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIA 500
           + +AAD    +WG + + G+LG G   P S  + Q V++L+GI   QVA G +HS  ++
Sbjct: 150 LALAADGQFFTWGKN-SHGQLGLGKEFP-SQASPQRVRSLEGIPLAQVAAGGAHSFALS 206



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 37/104 (35%), Positives = 54/104 (51%), Gaps = 3/104 (2%)

Query: 148 VRVRTVVSGSCAA-HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVS 206
           +R + VV  SC   H+ ++T  G ++++G    GQLGH        PR +  L    +  
Sbjct: 239 LRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQ 298

Query: 207 AACGRNHTLALT-ETGSVFAFGENKMGQLGLGNQTDA-VPSPAQ 248
            ACGR HTLA    +G ++AFG    GQLG G+  +   PSP +
Sbjct: 299 IACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVK 342


>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
          Length = 1049

 Score =  120 bits (300), Expect = 4e-27
 Identities = 95/343 (27%), Positives = 157/343 (45%), Gaps = 39/343 (11%)

Query: 139 PHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEG 198
           P +       RVR V  G    H++ +  +G +++ G N+ GQLGH  +++   P  +  
Sbjct: 25  PRKSDFFINKRVRDVGCG--LRHTVFVLDDGTVYTCGCNDLGQLGHEKSRK--KPEQVVA 80

Query: 199 LSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQI-MYNGQPIT 257
           L  + IV+ +CG  HTLAL + G V+A+G +  GQLGL    + +  P  I   +   I 
Sbjct: 81  LDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIV 140

Query: 258 KMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIE 317
           ++ACG   S+ +     ++ +G  +YGQLG  +D K     Q ++               
Sbjct: 141 QVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLK--------------- 185

Query: 318 KTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVK 377
                 +L +P      VA G  H+ VL     +F WG   +G+LG  ++ D  VP L+K
Sbjct: 186 -----SLLGIP---FMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLK 237

Query: 378 LFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGA------TNTSRESTMYPKAVQDLCGWR 431
                 +    I  G   + A+++ GG+F +GA       + S    + P+ V +L G  
Sbjct: 238 --SLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSI 295

Query: 432 IRSLACGK--SSIIVAADESTISWGPSPTFGELGYGDHKPKSS 472
           +  +ACG+  +S  V +     S+G     G+LG G    + S
Sbjct: 296 VTEIACGRQHTSAFVPSSGRIYSFGLGGN-GQLGTGSTSNRKS 337



 Score =  118 bits (295), Expect = 1e-26
 Identities = 83/272 (30%), Positives = 135/272 (49%), Gaps = 42/272 (15%)

Query: 151 RTVVSGSCA-AHSLLITTEGKLWSWGRNEKGQLGH-GDTKRVEAPRLIEGLSHEVIVSAA 208
           + +V+ SC  AH+L +  +G++++WG +  GQLG  G  + +  PR I+ LS   IV  A
Sbjct: 84  QNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVA 143

Query: 209 CGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYN--GQPITKMACGAEFS 266
           CG  H+LAL++   VF +G+NK GQLGLG       SP Q++ +  G P  ++A G   S
Sbjct: 144 CGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSP-QLLKSLLGIPFMQVAAGGAHS 202

Query: 267 MIMDCKGNLYSFGCPEYGQLGHNSDG-KFIA------RAQRIEYDCELVPRRVAIFIEKT 319
            ++   G ++ +G  ++GQLG N +  +++       R+Q+I Y C       A+    T
Sbjct: 203 FVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAAL----T 258

Query: 320 KDG-------------------------QILPVPNVVVRDVACGANHTLV-LDSQKRVFS 353
           K+G                         ++  +   +V ++ACG  HT   + S  R++S
Sbjct: 259 KEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYS 318

Query: 354 WGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRG 385
           +G GG G+LG     +   P  VK   +P  G
Sbjct: 319 FGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNG 350



 Score =  105 bits (262), Expect = 1e-22
 Identities = 95/336 (28%), Positives = 147/336 (43%), Gaps = 46/336 (13%)

Query: 174 WGRNEKGQLGHG--DTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKM 231
           WG    GQLG G  D + V  PR  +   ++ +    CG  HT+ + + G+V+  G N +
Sbjct: 4   WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63

Query: 232 GQLGLGNQTDAVPSPAQIM-YNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNS 290
           GQLG      +   P Q++  + Q I  ++CG   ++ ++ KG +Y++G    GQLG   
Sbjct: 64  GQLG---HEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVG 120

Query: 291 DGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKR 350
                        +C  VPR     I+   D QI+         VACG  H+L L     
Sbjct: 121 -----------SEECIRVPRN----IKSLSDIQIV--------QVACGYYHSLALSKASE 157

Query: 351 VFSWGFGGYGRLG-HAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWG 409
           VF WG   YG+LG   + K +  P+L+K     G    Q+ AG   SF ++  G +F WG
Sbjct: 158 VFCWGQNKYGQLGLGTDCKKQTSPQLLK--SLLGIPFMQVAAGGAHSFVLTLSGAIFGWG 215

Query: 410 ATNTSR-----ESTMY-PKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGELG 463
                +     E+  Y P  ++ L   +I  + CG+        E  +      TFG  G
Sbjct: 216 RNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVF-----TFGAGG 270

Query: 464 YGDHKPKSST---AAQEVKTLDGIFSEQVAMGYSHS 496
           YG     S++     ++V  L G    ++A G  H+
Sbjct: 271 YGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHT 306



 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 62/196 (31%), Positives = 89/196 (45%), Gaps = 25/196 (12%)

Query: 137 WGPHRYG------------------CLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNE 178
           WG ++YG                   L G+    V +G   AHS ++T  G ++ WGRN+
Sbjct: 161 WGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGG--AHSFVLTLSGAIFGWGRNK 218

Query: 179 KGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGN 238
            GQLG  D      P L++ L  + IV   CG +HT ALT+ G VF FG    GQLG  +
Sbjct: 219 FGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNS 278

Query: 239 QTDAVPSPAQIMYNGQPITKMACGAEF-SMIMDCKGNLYSFGCPEYGQLG----HNSDGK 293
            +  +         G  +T++ACG +  S  +   G +YSFG    GQLG     N    
Sbjct: 279 TSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSP 338

Query: 294 FIARAQRIEYDCELVP 309
           F  +     Y+ + +P
Sbjct: 339 FTVKGNWYPYNGQCLP 354



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 64/230 (27%), Positives = 100/230 (43%), Gaps = 36/230 (15%)

Query: 278 FGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVAC 337
           +G   +GQLG             I+ +  L PR+   FI K             VRDV C
Sbjct: 4   WGNASFGQLGLGG----------IDEEIVLEPRKSDFFINKR------------VRDVGC 41

Query: 338 GANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSF 397
           G  HT+ +     V++ G    G+LGH  +K    P  V   D   +    +  G   + 
Sbjct: 42  GLRHTVFVLDDGTVYTCGCNDLGQLGH--EKSRKKPEQVVALD--AQNIVAVSCGEAHTL 97

Query: 398 AVSEVGGLFFWGATNT-------SRESTMYPKAVQDLCGWRIRSLACGK-SSIIVAADES 449
           A+++ G ++ WG  +        S E    P+ ++ L   +I  +ACG   S+ ++    
Sbjct: 98  ALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASE 157

Query: 450 TISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVI 499
              WG +  +G+LG G    K  T+ Q +K+L GI   QVA G +HS V+
Sbjct: 158 VFCWGQNK-YGQLGLGTDC-KKQTSPQLLKSLLGIPFMQVAAGGAHSFVL 205



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 37/153 (24%), Positives = 69/153 (45%), Gaps = 7/153 (4%)

Query: 354 WGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNT 413
           WG   +G+LG     +E+V    K   F  +    +  G   +  V + G ++  G  + 
Sbjct: 4   WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63

Query: 414 SR----ESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTI-SWGPSPTFGELGYGDHK 468
            +    +S   P+ V  L    I +++CG++  +   D+  + +WG     G+LG    +
Sbjct: 64  GQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSD-GQLGLVGSE 122

Query: 469 PKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIAR 501
            +     + +K+L  I   QVA GY HSL +++
Sbjct: 123 -ECIRVPRNIKSLSDIQIVQVACGYYHSLALSK 154


>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
          Length = 1057

 Score =  120 bits (300), Expect = 4e-27
 Identities = 95/343 (27%), Positives = 157/343 (45%), Gaps = 39/343 (11%)

Query: 139 PHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEG 198
           P +       RVR V  G    H++ +  +G +++ G N+ GQLGH  +++   P  +  
Sbjct: 25  PRKSDFFINKRVRDVGCG--LRHTVFVLDDGTVYTCGCNDLGQLGHEKSRK--KPEQVVA 80

Query: 199 LSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQI-MYNGQPIT 257
           L  + IV+ +CG  HTLAL + G V+A+G +  GQLGL    + +  P  I   +   I 
Sbjct: 81  LDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIV 140

Query: 258 KMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIE 317
           ++ACG   S+ +     ++ +G  +YGQLG  +D K     Q ++               
Sbjct: 141 QVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLK--------------- 185

Query: 318 KTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVK 377
                 +L +P      VA G  H+ VL     +F WG   +G+LG  ++ D  VP L+K
Sbjct: 186 -----SLLGIP---FMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLK 237

Query: 378 LFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGA------TNTSRESTMYPKAVQDLCGWR 431
                 +    I  G   + A+++ GG+F +GA       + S    + P+ V +L G  
Sbjct: 238 --SLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSI 295

Query: 432 IRSLACGK--SSIIVAADESTISWGPSPTFGELGYGDHKPKSS 472
           +  +ACG+  +S  V +     S+G     G+LG G    + S
Sbjct: 296 VTEIACGRQHTSAFVPSSGRIYSFGLGGN-GQLGTGSTSNRKS 337



 Score =  118 bits (295), Expect = 1e-26
 Identities = 83/272 (30%), Positives = 135/272 (49%), Gaps = 42/272 (15%)

Query: 151 RTVVSGSCA-AHSLLITTEGKLWSWGRNEKGQLGH-GDTKRVEAPRLIEGLSHEVIVSAA 208
           + +V+ SC  AH+L +  +G++++WG +  GQLG  G  + +  PR I+ LS   IV  A
Sbjct: 84  QNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVA 143

Query: 209 CGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYN--GQPITKMACGAEFS 266
           CG  H+LAL++   VF +G+NK GQLGLG       SP Q++ +  G P  ++A G   S
Sbjct: 144 CGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSP-QLLKSLLGIPFMQVAAGGAHS 202

Query: 267 MIMDCKGNLYSFGCPEYGQLGHNSDG-KFIA------RAQRIEYDCELVPRRVAIFIEKT 319
            ++   G ++ +G  ++GQLG N +  +++       R+Q+I Y C       A+    T
Sbjct: 203 FVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAAL----T 258

Query: 320 KDG-------------------------QILPVPNVVVRDVACGANHTLV-LDSQKRVFS 353
           K+G                         ++  +   +V ++ACG  HT   + S  R++S
Sbjct: 259 KEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYS 318

Query: 354 WGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRG 385
           +G GG G+LG     +   P  VK   +P  G
Sbjct: 319 FGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNG 350



 Score =  105 bits (262), Expect = 1e-22
 Identities = 95/336 (28%), Positives = 147/336 (43%), Gaps = 46/336 (13%)

Query: 174 WGRNEKGQLGHG--DTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKM 231
           WG    GQLG G  D + V  PR  +   ++ +    CG  HT+ + + G+V+  G N +
Sbjct: 4   WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63

Query: 232 GQLGLGNQTDAVPSPAQIM-YNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNS 290
           GQLG      +   P Q++  + Q I  ++CG   ++ ++ KG +Y++G    GQLG   
Sbjct: 64  GQLG---HEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVG 120

Query: 291 DGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKR 350
                        +C  VPR     I+   D QI+         VACG  H+L L     
Sbjct: 121 -----------SEECIRVPRN----IKSLSDIQIV--------QVACGYYHSLALSKASE 157

Query: 351 VFSWGFGGYGRLG-HAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWG 409
           VF WG   YG+LG   + K +  P+L+K     G    Q+ AG   SF ++  G +F WG
Sbjct: 158 VFCWGQNKYGQLGLGTDCKKQTSPQLLK--SLLGIPFMQVAAGGAHSFVLTLSGAIFGWG 215

Query: 410 ATNTSR-----ESTMY-PKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGELG 463
                +     E+  Y P  ++ L   +I  + CG+        E  +      TFG  G
Sbjct: 216 RNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVF-----TFGAGG 270

Query: 464 YGDHKPKSST---AAQEVKTLDGIFSEQVAMGYSHS 496
           YG     S++     ++V  L G    ++A G  H+
Sbjct: 271 YGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHT 306



 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 62/196 (31%), Positives = 89/196 (45%), Gaps = 25/196 (12%)

Query: 137 WGPHRYG------------------CLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNE 178
           WG ++YG                   L G+    V +G   AHS ++T  G ++ WGRN+
Sbjct: 161 WGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGG--AHSFVLTLSGAIFGWGRNK 218

Query: 179 KGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGN 238
            GQLG  D      P L++ L  + IV   CG +HT ALT+ G VF FG    GQLG  +
Sbjct: 219 FGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNS 278

Query: 239 QTDAVPSPAQIMYNGQPITKMACGAEF-SMIMDCKGNLYSFGCPEYGQLG----HNSDGK 293
            +  +         G  +T++ACG +  S  +   G +YSFG    GQLG     N    
Sbjct: 279 TSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSP 338

Query: 294 FIARAQRIEYDCELVP 309
           F  +     Y+ + +P
Sbjct: 339 FTVKGNWYPYNGQCLP 354



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 64/230 (27%), Positives = 100/230 (43%), Gaps = 36/230 (15%)

Query: 278 FGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVAC 337
           +G   +GQLG             I+ +  L PR+   FI K             VRDV C
Sbjct: 4   WGNASFGQLGLGG----------IDEEIVLEPRKSDFFINKR------------VRDVGC 41

Query: 338 GANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSF 397
           G  HT+ +     V++ G    G+LGH  +K    P  V   D   +    +  G   + 
Sbjct: 42  GLRHTVFVLDDGTVYTCGCNDLGQLGH--EKSRKKPEQVVALD--AQNIVAVSCGEAHTL 97

Query: 398 AVSEVGGLFFWGATNT-------SRESTMYPKAVQDLCGWRIRSLACGK-SSIIVAADES 449
           A+++ G ++ WG  +        S E    P+ ++ L   +I  +ACG   S+ ++    
Sbjct: 98  ALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASE 157

Query: 450 TISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVI 499
              WG +  +G+LG G    K  T+ Q +K+L GI   QVA G +HS V+
Sbjct: 158 VFCWGQNK-YGQLGLGTDC-KKQTSPQLLKSLLGIPFMQVAAGGAHSFVL 205



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 37/153 (24%), Positives = 69/153 (45%), Gaps = 7/153 (4%)

Query: 354 WGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNT 413
           WG   +G+LG     +E+V    K   F  +    +  G   +  V + G ++  G  + 
Sbjct: 4   WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63

Query: 414 SR----ESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTI-SWGPSPTFGELGYGDHK 468
            +    +S   P+ V  L    I +++CG++  +   D+  + +WG     G+LG    +
Sbjct: 64  GQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSD-GQLGLVGSE 122

Query: 469 PKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIAR 501
            +     + +K+L  I   QVA GY HSL +++
Sbjct: 123 -ECIRVPRNIKSLSDIQIVQVACGYYHSLALSK 154


>gi|4557445 regulator of chromosome condensation and BTB domain
           containing protein 2 [Homo sapiens]
          Length = 551

 Score =  118 bits (296), Expect = 1e-26
 Identities = 83/274 (30%), Positives = 132/274 (48%), Gaps = 30/274 (10%)

Query: 139 PHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAP-RLIE 197
           P R   L G ++  +  GS   H +L TTEG++++WG N   QLG+G T     P  +  
Sbjct: 89  PRRLDSLNGKKIACLSYGS-GPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHIST 147

Query: 198 GLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIM--YNGQP 255
            LS++ ++  ACG  H+L LT  G VFA+G N  GQ+G G+  +  P P ++      + 
Sbjct: 148 NLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQ-PIPRRVTGCLQNKV 206

Query: 256 ITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIF 315
           +  +ACG    M +   G +Y +G    GQLG  + G             +  P RVA  
Sbjct: 207 VVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGN------------QPTPCRVAA- 253

Query: 316 IEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRL 375
                      +  + V+ VACG  HTLVL  + +V++WG   YG+LG   + ++  P  
Sbjct: 254 -----------LQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTP 302

Query: 376 VKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWG 409
           V +        +  ++ +T S A ++ G ++ WG
Sbjct: 303 VTVEKDRIIEIAACHSTHT-SAAKTQGGHVYMWG 335



 Score =  106 bits (265), Expect = 5e-23
 Identities = 70/239 (29%), Positives = 115/239 (48%), Gaps = 41/239 (17%)

Query: 128 AYRNLGQNLWGPHRYGCLAGVRV--RTVVSGSCAA-HSLLITTEGKLWSWGRNEKGQLGH 184
           AY  LG          C     +  + V+  +C + HSL++T++G++++WG N  GQ+G 
Sbjct: 127 AYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGS 186

Query: 185 GDTKRVEAPRLIEG-LSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAV 243
           G T     PR + G L ++V+V+ ACG+   +A+ +TG V+ +G N  GQLGLGN  +  
Sbjct: 187 GSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQ- 245

Query: 244 PSPAQI-MYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIE 302
           P+P ++    G  + ++ACG   ++++  +G +Y++G   YGQLG  +            
Sbjct: 246 PTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGN------------ 293

Query: 303 YDCELVPRRVAIFIEKTKDGQILPVPNVVVRD-----VACGANHTLVLDSQ-KRVFSWG 355
                            K  Q  P P  V +D      AC + HT    +Q   V+ WG
Sbjct: 294 -----------------KSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWG 335



 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 72/270 (26%), Positives = 121/270 (44%), Gaps = 37/270 (13%)

Query: 212 NHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIM-D 270
           N  L  T    +F  G N  G LGLG+    +        NG+ I  ++ G+   +++  
Sbjct: 56  NEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLAT 115

Query: 271 CKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNV 330
            +G ++++G   Y QLG+ +                LVP  ++  +            N 
Sbjct: 116 TEGEVFTWGHNAYSQLGNGTTNH------------GLVPCHISTNLS-----------NK 152

Query: 331 VVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIY 390
            V +VACG+ H+LVL S   VF+WG+   G++G     ++ +PR V       +    I 
Sbjct: 153 QVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRV-TGCLQNKVVVTIA 211

Query: 391 AGYTCSFAVSEVGGLFFWGAT--------NTSRESTMYPKAVQDLCGWRIRSLACGKSSI 442
            G  C  AV + G ++ WG          N+  + T  P  V  L G R++ +ACG +  
Sbjct: 212 CGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPT--PCRVAALQGIRVQRVACGYAHT 269

Query: 443 IVAADESTI-SWGPSPTFGELGYGDHKPKS 471
           +V  DE  + +WG + ++G+LG G+   +S
Sbjct: 270 LVLTDEGQVYAWGAN-SYGQLGTGNKSNQS 298



 Score = 90.1 bits (222), Expect = 4e-18
 Identities = 66/267 (24%), Positives = 115/267 (43%), Gaps = 27/267 (10%)

Query: 154 VSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRN- 212
           V GS     L  T   +++  G N  G LG GD +    PR ++ L+ + I   + G   
Sbjct: 50  VFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGP 109

Query: 213 HTLALTETGSVFAFGENKMGQLGLGNQTDA-VPSPAQIMYNGQPITKMACGAEFSMIMDC 271
           H +  T  G VF +G N   QLG G      VP       + + + ++ACG+  S+++  
Sbjct: 110 HIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTS 169

Query: 272 KGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVV 331
            G ++++G    GQ+G  S               + +PRRV   ++           N V
Sbjct: 170 DGEVFAWGYNNSGQVGSGSTVN------------QPIPRRVTGCLQ-----------NKV 206

Query: 332 VRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYA 391
           V  +ACG    + +     V+ WG+ G G+LG     ++  P   ++    G    ++  
Sbjct: 207 VVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTP--CRVAALQGIRVQRVAC 264

Query: 392 GYTCSFAVSEVGGLFFWGATNTSREST 418
           GY  +  +++ G ++ WGA +  +  T
Sbjct: 265 GYAHTLVLTDEGQVYAWGANSYGQLGT 291



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 43/173 (24%), Positives = 81/173 (46%), Gaps = 13/173 (7%)

Query: 341 HTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVS 400
           H ++  ++  VF+WG   Y +LG+      +VP  +   +   +   ++  G   S  ++
Sbjct: 110 HIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHIST-NLSNKQVIEVACGSYHSLVLT 168

Query: 401 EVGGLFFWGATNTSRE---STMYPKAVQDLCGWR----IRSLACGKSSIIVAADESTIS- 452
             G +F WG  N+ +    ST+     + + G      + ++ACG+   +   D   +  
Sbjct: 169 SDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYV 228

Query: 453 WGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARDESE 505
           WG +   G+LG G+   + +     V  L GI  ++VA GY+H+LV+  DE +
Sbjct: 229 WGYNGN-GQLGLGNSGNQPTPC--RVAALQGIRVQRVACGYAHTLVLT-DEGQ 277


>gi|57242759 regulator of chromosome condensation (RCC1) and BTB
           (POZ) domain containing protein 1 [Homo sapiens]
          Length = 531

 Score =  113 bits (283), Expect = 4e-25
 Identities = 79/274 (28%), Positives = 136/274 (49%), Gaps = 30/274 (10%)

Query: 139 PHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAP-RLIE 197
           P +   L G +++++  GS   H LL T +G +++WG N   QLG+G T +  AP ++  
Sbjct: 65  PKKLEGLCGKKIKSLSYGS-GPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCT 123

Query: 198 GLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIM--YNGQP 255
            L  + +V  ACG +H++AL   G VFA+G N  GQ+G G+  +  P+P ++    + + 
Sbjct: 124 NLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQ-PTPRKVTNCLHIKR 182

Query: 256 ITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIF 315
           +  +ACG   SM +   G +Y +G    GQLG  ++G             +L P RVA  
Sbjct: 183 VVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGN------------QLTPVRVAA- 229

Query: 316 IEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRL 375
                      + +V V  + CG  HTL L  +  +++WG   YG+LG   + + + P  
Sbjct: 230 -----------LHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAH 278

Query: 376 VKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWG 409
           + +        +  ++ +T S A ++ G ++ WG
Sbjct: 279 IMVEKERVVEIAACHSAHT-SAAKTQGGHVYMWG 311



 Score =  106 bits (264), Expect = 6e-23
 Identities = 76/277 (27%), Positives = 130/277 (46%), Gaps = 30/277 (10%)

Query: 145 LAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVI 204
           +A +R +  V G+ A+ +L +T   +++ +G N    LG GD +    P+ +EGL  + I
Sbjct: 18  IASIR-KACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKI 76

Query: 205 VSAACGRN-HTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYN--GQPITKMAC 261
            S + G   H L  TE G V+A+G N   QLG G     + +P Q+  N   + + ++AC
Sbjct: 77  KSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGI-APVQVCTNLLIKQVVEVAC 135

Query: 262 GAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKD 321
           G+  SM +   G ++++G    GQ+G  S               +  PR+V         
Sbjct: 136 GSHHSMALAADGEVFAWGYNNCGQVGSGSTAN------------QPTPRKVT-------- 175

Query: 322 GQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDF 381
              L +  VV   +ACG   ++ +     V+ WG+ G G+LG     +++ P  V++   
Sbjct: 176 -NCLHIKRVV--GIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTP--VRVAAL 230

Query: 382 PGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSREST 418
                +QI  GY  + A+++ G L+ WGA    +  T
Sbjct: 231 HSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGT 267



 Score = 77.0 bits (188), Expect = 4e-14
 Identities = 69/264 (26%), Positives = 118/264 (44%), Gaps = 35/264 (13%)

Query: 212 NHTLALTETGSVFAFGENKMGQLGLG-NQTDAVPSPAQIMYNGQPITKMACGAEFSMIMD 270
           +  L +T+   VF FG N    LG G NQ+  VP   + +  G+ I  ++ G+   +++ 
Sbjct: 32  SEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLC-GKKIKSLSYGSGPHVLLS 90

Query: 271 CK-GNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPN 329
            + G +Y++G   Y QLG+ +  + IA  Q                         L +  
Sbjct: 91  TEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTN---------------------LLIKQ 129

Query: 330 VVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQI 389
           VV  +VACG++H++ L +   VF+WG+   G++G     ++  PR V       R    I
Sbjct: 130 VV--EVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVG-I 186

Query: 390 YAGYTCSFAVSEVGGLFFWGATNT------SRESTMYPKAVQDLCGWRIRSLACGKSSII 443
             G T S AV + G ++ WG          +  + + P  V  L    +  + CG +  +
Sbjct: 187 ACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTL 246

Query: 444 VAADESTI-SWGPSPTFGELGYGD 466
              DE  + +WG + T+G+LG G+
Sbjct: 247 ALTDEGLLYAWGAN-TYGQLGTGN 269



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 42/167 (25%), Positives = 75/167 (44%), Gaps = 12/167 (7%)

Query: 341 HTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVS 400
           H L+      V++WG  GY +LG+      + P  V   +   +   ++  G   S A++
Sbjct: 86  HVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQV-CTNLLIKQVVEVACGSHHSMALA 144

Query: 401 EVGGLFFWGATNT------SRESTMYPKAVQD-LCGWRIRSLACGKSSIIVAADESTI-S 452
             G +F WG  N       S  +   P+ V + L   R+  +ACG++S +   D   +  
Sbjct: 145 ADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYG 204

Query: 453 WGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVI 499
           WG +   G+LG G++  + +     V  L  +   Q+  GY+H+L +
Sbjct: 205 WGYNGN-GQLGLGNNGNQLTPV--RVAALHSVCVNQIVCGYAHTLAL 248



 Score = 38.5 bits (88), Expect = 0.015
 Identities = 26/92 (28%), Positives = 48/92 (52%), Gaps = 10/92 (10%)

Query: 416 ESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTI--SWGPSPTFGELGYGDHKPKSST 473
           +ST+ PK ++ LCG +I+SL+ G    ++ + E  +  +WG +  + +LG G     ++ 
Sbjct: 60  QSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHN-GYSQLGNG----TTNQ 114

Query: 474 AAQEVKTLDGIFSEQ---VAMGYSHSLVIARD 502
               V+    +  +Q   VA G  HS+ +A D
Sbjct: 115 GIAPVQVCTNLLIKQVVEVACGSHHSMALAAD 146


>gi|110825982 hect domain and RLD 5 [Homo sapiens]
          Length = 1024

 Score =  111 bits (278), Expect = 1e-24
 Identities = 73/221 (33%), Positives = 120/221 (54%), Gaps = 28/221 (12%)

Query: 161 HSLLITTEGKLWSWGRNEKGQLGHGDT-KRVEAPRLIEGLSHEVIVSAACGRNHTLALTE 219
           HSL ++  G+L++WG+N  GQLG G        P+++E L+   +   + G  H++AL+ 
Sbjct: 149 HSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSM 208

Query: 220 TGSVFAFGENKMGQLGLGNQTDAVPSPAQIM-YNGQPITKMACGAEFSMIMDCKGNLYSF 278
           +G+++++G+N+ GQLGLG+ T++   P+ I   + Q +  +ACG   S ++   G L++F
Sbjct: 209 SGNIYSWGKNECGQLGLGH-TESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTF 267

Query: 279 GCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACG 338
           G  ++GQLGHNS               EL P  VA  +               V  +ACG
Sbjct: 268 GAGKHGQLGHNSTQN------------ELRPCLVAELV------------GYRVTQIACG 303

Query: 339 ANHTLVLDSQ-KRVFSWGFGGYGRLGHAEQKDEMVPRLVKL 378
             HTL   S   +VFS+G G  G+LG+   +D+++P  VK+
Sbjct: 304 RWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKV 344



 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 74/265 (27%), Positives = 129/265 (48%), Gaps = 41/265 (15%)

Query: 148 VRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSA 207
           +++ +V  G  A H L+++++GK + +           D   ++  R    L  + I+  
Sbjct: 97  MKIHSVDQG--AEHMLILSSDGKPFEY-----------DNYSMKHLRFESILQEKKIIQI 143

Query: 208 ACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMY-NGQPITKMACGAEFS 266
            CG  H+LAL++ G +FA+G+N  GQLG+G +  +  +P  + +  G P+ +++ G   S
Sbjct: 144 TCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHS 203

Query: 267 MIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILP 326
           M +   GN+YS+G  E GQLG                        +     K     I  
Sbjct: 204 MALSMSGNIYSWGKNECGQLG------------------------LGHTESKDDPSLIEG 239

Query: 327 VPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGA 386
           + N  V  VACG +H+ +L     +F++G G +G+LGH   ++E+ P LV   +  G   
Sbjct: 240 LDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVA--ELVGYRV 297

Query: 387 SQIYAGYTCSFA-VSEVGGLFFWGA 410
           +QI  G   + A VS++G +F +G+
Sbjct: 298 TQIACGRWHTLAYVSDLGKVFSFGS 322



 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 54/145 (37%), Positives = 85/145 (58%), Gaps = 3/145 (2%)

Query: 145 LAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVI 204
           LAGV +  + +G   AHS+ ++  G ++SWG+NE GQLG G T+  + P LIEGL ++ +
Sbjct: 188 LAGVPLAQISAGE--AHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKV 245

Query: 205 VSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAE 264
              ACG +H+  LT+ G +F FG  K GQLG  +  + +         G  +T++ACG  
Sbjct: 246 EFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRW 305

Query: 265 FSM-IMDCKGNLYSFGCPEYGQLGH 288
            ++  +   G ++SFG  + GQLG+
Sbjct: 306 HTLAYVSDLGKVFSFGSGKDGQLGN 330



 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 73/347 (21%), Positives = 142/347 (40%), Gaps = 55/347 (15%)

Query: 193 PRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYN 252
           P+ I+   +  I S   G  H L L+  G  F +    M  L             + +  
Sbjct: 88  PKCIKLGKNMKIHSVDQGAEHMLILSSDGKPFEYDNYSMKHLRF-----------ESILQ 136

Query: 253 GQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRV 312
            + I ++ CG   S+ +   G L+++G   +GQLG           Q +E+         
Sbjct: 137 EKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEH--------- 187

Query: 313 AIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGR--LGHAEQKDE 370
                         +  V +  ++ G  H++ L     ++SWG    G+  LGH E KD+
Sbjct: 188 --------------LAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDD 233

Query: 371 MVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGA------TNTSRESTMYPKAV 424
             P L++  D   +    +  G + S  +++ G LF +GA       + S ++ + P  V
Sbjct: 234 --PSLIEGLD--NQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLV 289

Query: 425 QDLCGWRIRSLACGK-SSIIVAADESTISWGPSPTFGELGYGDHK------PKSSTAAQE 477
            +L G+R+  +ACG+  ++   +D   +    S   G+LG G  +      P   ++++E
Sbjct: 290 AELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEE 349

Query: 478 VKTLDGIFSEQVAM--GYSHSLVIARDESETEKEKIKKLPEYNPRTL 522
           +K       +++ M  G + S+++   +  +     + +P  N  T+
Sbjct: 350 LKLESHTSEKELIMIAGGNQSILLWIKKENSYVNLKRTIPTLNEGTV 396



 Score = 32.7 bits (73), Expect = 0.83
 Identities = 30/100 (30%), Positives = 43/100 (43%), Gaps = 14/100 (14%)

Query: 104 GQLLIFGATNWDLIGRKEVPKQQAAYRNLGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSL 163
           G L  FGA     +G            N  QN   P     L G RV  +  G    H+L
Sbjct: 262 GLLFTFGAGKHGQLGH-----------NSTQNELRPCLVAELVGYRVTQIACGRW--HTL 308

Query: 164 LITTE-GKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHE 202
              ++ GK++S+G  + GQLG+G T+    P  ++  S E
Sbjct: 309 AYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSE 348


>gi|61563742 hect domain and RLD 6 [Homo sapiens]
          Length = 1022

 Score =  106 bits (264), Expect = 6e-23
 Identities = 76/269 (28%), Positives = 129/269 (47%), Gaps = 27/269 (10%)

Query: 161 HSLLITTEGKLWSWGRNEKGQLGHGDTKRVE-APRLIEGLSHEVIVSAACGRNHTLALTE 219
           HSL +  +G++++WG   +GQLG G+ K +   P+ I  L+   I+  +CG  H+LAL++
Sbjct: 86  HSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSK 145

Query: 220 TGSVFAFGENKMGQLGLGNQTDAVPSPAQIM-YNGQPITKMACGAEFSMIMDCKGNLYSF 278
              VF++G+N  GQLGLG +  +  SP ++    G P+ ++A G   S  +   G  + +
Sbjct: 146 DSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGW 205

Query: 279 GCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACG 338
           G    GQL                    L  R V +  +  K   +  + N+ V  ++CG
Sbjct: 206 GSNSAGQLA-------------------LSGRNVPV--QSNKPLSVGALKNLGVVYISCG 244

Query: 339 ANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAG-YTCSF 397
             HT VL    +VF++G    G+LG++   ++  P+LV+  D      SQI  G Y    
Sbjct: 245 DAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERID---GLVSQIDCGSYHTLA 301

Query: 398 AVSEVGGLFFWGATNTSRESTMYPKAVQD 426
            V   G +  +G   +      +P+A+ +
Sbjct: 302 YVHTTGQVVSFGHGPSDTSKPTHPEALTE 330



 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 81/305 (26%), Positives = 137/305 (44%), Gaps = 40/305 (13%)

Query: 204 IVSAACGRNHTLALTETGSVFAFGENKMGQLG-LGNQTDAVPSPAQIMYNGQPITKMACG 262
           ++ AA G  H+L L     V + G+N  GQLG  G Q   +P P Q +     +  ++CG
Sbjct: 25  LLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQAL-ETLIVDLVSCG 83

Query: 263 AEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDG 322
            E S+ +  KG ++++G    GQLG       I   + I +     P++           
Sbjct: 84  KEHSLAVCHKGRVFAWGAGSEGQLG-------IGEFKEISF----TPKK----------- 121

Query: 323 QILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQ-KDEMVPRLVKLFDF 381
            I+ + ++ +  V+CG  H+L L    +VFSWG   +G+LG  ++   +  P+ V+  + 
Sbjct: 122 -IMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLE- 179

Query: 382 PGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR---------ESTMYPKAVQDLCGWRI 432
            G   +Q+ AG   SFA+S  G  F WG+ +  +           +  P +V  L    +
Sbjct: 180 -GIPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGV 238

Query: 433 RSLACGKSSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMG 492
             ++CG +   V   +  +        G+LGY     K     Q V+ +DG+ S Q+  G
Sbjct: 239 VYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEK--RGPQLVERIDGLVS-QIDCG 295

Query: 493 YSHSL 497
             H+L
Sbjct: 296 SYHTL 300



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 52/181 (28%), Positives = 84/181 (46%), Gaps = 12/181 (6%)

Query: 328 PNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGAS 387
           P   +   A G  H+L+L +  RV S G    G+LG    +   +P  ++  +       
Sbjct: 21  PGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALE--TLIVD 78

Query: 388 QIYAGYTCSFAVSEVGGLFFWGATNTS-------RESTMYPKAVQDLCGWRIRSLACGK- 439
            +  G   S AV   G +F WGA +         +E +  PK +  L   +I  ++CG  
Sbjct: 79  LVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHY 138

Query: 440 SSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVI 499
            S+ ++ D    SWG + + G+LG G   P S  + Q V++L+GI   QVA G +HS  +
Sbjct: 139 HSLALSKDSQVFSWGKN-SHGQLGLGKEFP-SQASPQRVRSLEGIPLAQVAAGGAHSFAL 196

Query: 500 A 500
           +
Sbjct: 197 S 197



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 44/145 (30%), Positives = 69/145 (47%), Gaps = 7/145 (4%)

Query: 139 PHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQL---GHGDTKRVEAPRL 195
           P R   L G+ +  V +G   AHS  ++  G  + WG N  GQL   G     +   P  
Sbjct: 172 PQRVRSLEGIPLAQVAAGG--AHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLS 229

Query: 196 IEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQP 255
           +  L +  +V  +CG  HT  LT+ G VF FG+N+ GQLG  + T     P  +      
Sbjct: 230 VGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGY-SPTPEKRGPQLVERIDGL 288

Query: 256 ITKMACGAEFSM-IMDCKGNLYSFG 279
           ++++ CG+  ++  +   G + SFG
Sbjct: 289 VSQIDCGSYHTLAYVHTTGQVVSFG 313



 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 65/260 (25%), Positives = 110/260 (42%), Gaps = 37/260 (14%)

Query: 253 GQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRV 312
           G  + + A G   S+++     + S G    GQLG          AQR E     +P   
Sbjct: 22  GAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRG-------AQRGE-----LPE-- 67

Query: 313 AIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKD-EM 371
                      I  +  ++V  V+CG  H+L +  + RVF+WG G  G+LG  E K+   
Sbjct: 68  ----------PIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISF 117

Query: 372 VPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR-------ESTMYPKAV 424
            P+  K+         Q+  G+  S A+S+   +F WG  +  +        S   P+ V
Sbjct: 118 TPK--KIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRV 175

Query: 425 QDLCGWRIRSLACGKS-SIIVAADESTISWGPSPTFGELGY-GDHKPKSSTAAQEVKTLD 482
           + L G  +  +A G + S  ++   ++  WG S + G+L   G + P  S     V  L 
Sbjct: 176 RSLEGIPLAQVAAGGAHSFALSLCGTSFGWG-SNSAGQLALSGRNVPVQSNKPLSVGALK 234

Query: 483 GIFSEQVAMGYSHSLVIARD 502
            +    ++ G +H+ V+ +D
Sbjct: 235 NLGVVYISCGDAHTAVLTQD 254


>gi|114796646 regulator of chromosome condensation 1 isoform b [Homo
           sapiens]
          Length = 438

 Score =  104 bits (259), Expect = 2e-22
 Identities = 96/387 (24%), Positives = 170/387 (43%), Gaps = 27/387 (6%)

Query: 132 LGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVE 191
           LG+N+    +   L  +    V + +   H++ ++  G+++S+G N++G LG  DT  VE
Sbjct: 67  LGENVM-ERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGR-DTS-VE 123

Query: 192 APRLIEGLSH--EVIVSAACGRNHTLALTETGSVFAFGE--NKMGQLGLGNQTDAVPSPA 247
              ++ G     E +V  + G +HT ALT+ G VF +G   +  G +GL         P 
Sbjct: 124 GSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV 183

Query: 248 QIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCEL 307
           Q+  +  P+ K+A G +  +++   G+LY+ GC E GQLG   +  F  R  R   +  L
Sbjct: 184 QVQLD-VPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE-LFANRGGRQGLERLL 241

Query: 308 VPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQ 367
           VP+ V +   K++  +     +V  +D  CGA  T  +  +  V+ +G   Y +LG    
Sbjct: 242 VPKCVML---KSRGSR----GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGT 294

Query: 368 KDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR-------ESTMY 420
           +   +P+ +  F    +       G   +  +   G  +  G     R       E    
Sbjct: 295 ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSI 354

Query: 421 PKAVQDLCGWRIRSLACGKS-SIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVK 479
           P  +  L    + S+ACG S    V  D    +WG    + +LG G  +   S      K
Sbjct: 355 PTLISRLPA--VSSVACGASVGYAVTKDGRVFAWGMGTNY-QLGTGQDEDAWSPVEMMGK 411

Query: 480 TLDGIFSEQVAMGYSHSLVIARDESET 506
            L+      V+ G  H++++ +D+ ++
Sbjct: 412 QLENRVVLSVSSGGQHTVLLVKDKEQS 438



 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 51/182 (28%), Positives = 75/182 (41%), Gaps = 28/182 (15%)

Query: 200 SHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKM 259
           S  V  + +C  +H    TE G V   G+  +GQLGLG        PA +    + + + 
Sbjct: 31  SRRVPGARSCQVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQA 89

Query: 260 ACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKT 319
             G   ++ +   G +YSFGC + G LG ++  +            E+VP +V +     
Sbjct: 90  EAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVE----------GSEMVPGKVEL----- 134

Query: 320 KDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGF--GGYGRLGHAE-QKDEMVPRLV 376
                       V  V+ G +HT  L    RVF WG      G +G  E  K  MVP  V
Sbjct: 135 ---------QEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQV 185

Query: 377 KL 378
           +L
Sbjct: 186 QL 187


>gi|114796644 regulator of chromosome condensation 1 isoform a [Homo
           sapiens]
          Length = 452

 Score =  104 bits (259), Expect = 2e-22
 Identities = 96/387 (24%), Positives = 170/387 (43%), Gaps = 27/387 (6%)

Query: 132 LGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVE 191
           LG+N+    +   L  +    V + +   H++ ++  G+++S+G N++G LG  DT  VE
Sbjct: 81  LGENVM-ERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGR-DTS-VE 137

Query: 192 APRLIEGLSH--EVIVSAACGRNHTLALTETGSVFAFGE--NKMGQLGLGNQTDAVPSPA 247
              ++ G     E +V  + G +HT ALT+ G VF +G   +  G +GL         P 
Sbjct: 138 GSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV 197

Query: 248 QIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCEL 307
           Q+  +  P+ K+A G +  +++   G+LY+ GC E GQLG   +  F  R  R   +  L
Sbjct: 198 QVQLD-VPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE-LFANRGGRQGLERLL 255

Query: 308 VPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQ 367
           VP+ V +   K++  +     +V  +D  CGA  T  +  +  V+ +G   Y +LG    
Sbjct: 256 VPKCVML---KSRGSR----GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGT 308

Query: 368 KDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR-------ESTMY 420
           +   +P+ +  F    +       G   +  +   G  +  G     R       E    
Sbjct: 309 ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSI 368

Query: 421 PKAVQDLCGWRIRSLACGKS-SIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVK 479
           P  +  L    + S+ACG S    V  D    +WG    + +LG G  +   S      K
Sbjct: 369 PTLISRLPA--VSSVACGASVGYAVTKDGRVFAWGMGTNY-QLGTGQDEDAWSPVEMMGK 425

Query: 480 TLDGIFSEQVAMGYSHSLVIARDESET 506
            L+      V+ G  H++++ +D+ ++
Sbjct: 426 QLENRVVLSVSSGGQHTVLLVKDKEQS 452



 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 48/170 (28%), Positives = 70/170 (41%), Gaps = 28/170 (16%)

Query: 212 NHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDC 271
           +H    TE G V   G+  +GQLGLG        PA +    + + +   G   ++ +  
Sbjct: 57  SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAGGMHTVCLSK 115

Query: 272 KGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVV 331
            G +YSFGC + G LG ++  +            E+VP +V +                 
Sbjct: 116 SGQVYSFGCNDEGALGRDTSVE----------GSEMVPGKVEL--------------QEK 151

Query: 332 VRDVACGANHTLVLDSQKRVFSWGF--GGYGRLGHAE-QKDEMVPRLVKL 378
           V  V+ G +HT  L    RVF WG      G +G  E  K  MVP  V+L
Sbjct: 152 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL 201


>gi|4502801 regulator of chromosome condensation 1 isoform c [Homo
           sapiens]
          Length = 421

 Score =  104 bits (259), Expect = 2e-22
 Identities = 96/387 (24%), Positives = 170/387 (43%), Gaps = 27/387 (6%)

Query: 132 LGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVE 191
           LG+N+    +   L  +    V + +   H++ ++  G+++S+G N++G LG  DT  VE
Sbjct: 50  LGENVM-ERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGR-DTS-VE 106

Query: 192 APRLIEGLSH--EVIVSAACGRNHTLALTETGSVFAFGE--NKMGQLGLGNQTDAVPSPA 247
              ++ G     E +V  + G +HT ALT+ G VF +G   +  G +GL         P 
Sbjct: 107 GSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV 166

Query: 248 QIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCEL 307
           Q+  +  P+ K+A G +  +++   G+LY+ GC E GQLG   +  F  R  R   +  L
Sbjct: 167 QVQLD-VPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE-LFANRGGRQGLERLL 224

Query: 308 VPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQ 367
           VP+ V +   K++  +     +V  +D  CGA  T  +  +  V+ +G   Y +LG    
Sbjct: 225 VPKCVML---KSRGSR----GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGT 277

Query: 368 KDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR-------ESTMY 420
           +   +P+ +  F    +       G   +  +   G  +  G     R       E    
Sbjct: 278 ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSI 337

Query: 421 PKAVQDLCGWRIRSLACGKS-SIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVK 479
           P  +  L    + S+ACG S    V  D    +WG    + +LG G  +   S      K
Sbjct: 338 PTLISRLPA--VSSVACGASVGYAVTKDGRVFAWGMGTNY-QLGTGQDEDAWSPVEMMGK 394

Query: 480 TLDGIFSEQVAMGYSHSLVIARDESET 506
            L+      V+ G  H++++ +D+ ++
Sbjct: 395 QLENRVVLSVSSGGQHTVLLVKDKEQS 421



 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 48/170 (28%), Positives = 70/170 (41%), Gaps = 28/170 (16%)

Query: 212 NHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDC 271
           +H    TE G V   G+  +GQLGLG        PA +    + + +   G   ++ +  
Sbjct: 26  SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAGGMHTVCLSK 84

Query: 272 KGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVV 331
            G +YSFGC + G LG ++  +            E+VP +V +                 
Sbjct: 85  SGQVYSFGCNDEGALGRDTSVE----------GSEMVPGKVEL--------------QEK 120

Query: 332 VRDVACGANHTLVLDSQKRVFSWGF--GGYGRLGHAE-QKDEMVPRLVKL 378
           V  V+ G +HT  L    RVF WG      G +G  E  K  MVP  V+L
Sbjct: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL 170


>gi|114796642 regulator of chromosome condensation 1 [Homo sapiens]
          Length = 421

 Score =  104 bits (259), Expect = 2e-22
 Identities = 96/387 (24%), Positives = 170/387 (43%), Gaps = 27/387 (6%)

Query: 132 LGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVE 191
           LG+N+    +   L  +    V + +   H++ ++  G+++S+G N++G LG  DT  VE
Sbjct: 50  LGENVM-ERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGR-DTS-VE 106

Query: 192 APRLIEGLSH--EVIVSAACGRNHTLALTETGSVFAFGE--NKMGQLGLGNQTDAVPSPA 247
              ++ G     E +V  + G +HT ALT+ G VF +G   +  G +GL         P 
Sbjct: 107 GSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV 166

Query: 248 QIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCEL 307
           Q+  +  P+ K+A G +  +++   G+LY+ GC E GQLG   +  F  R  R   +  L
Sbjct: 167 QVQLD-VPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE-LFANRGGRQGLERLL 224

Query: 308 VPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQ 367
           VP+ V +   K++  +     +V  +D  CGA  T  +  +  V+ +G   Y +LG    
Sbjct: 225 VPKCVML---KSRGSR----GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGT 277

Query: 368 KDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR-------ESTMY 420
           +   +P+ +  F    +       G   +  +   G  +  G     R       E    
Sbjct: 278 ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSI 337

Query: 421 PKAVQDLCGWRIRSLACGKS-SIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVK 479
           P  +  L    + S+ACG S    V  D    +WG    + +LG G  +   S      K
Sbjct: 338 PTLISRLPA--VSSVACGASVGYAVTKDGRVFAWGMGTNY-QLGTGQDEDAWSPVEMMGK 394

Query: 480 TLDGIFSEQVAMGYSHSLVIARDESET 506
            L+      V+ G  H++++ +D+ ++
Sbjct: 395 QLENRVVLSVSSGGQHTVLLVKDKEQS 421



 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 48/170 (28%), Positives = 70/170 (41%), Gaps = 28/170 (16%)

Query: 212 NHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDC 271
           +H    TE G V   G+  +GQLGLG        PA +    + + +   G   ++ +  
Sbjct: 26  SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAGGMHTVCLSK 84

Query: 272 KGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVV 331
            G +YSFGC + G LG ++  +            E+VP +V +                 
Sbjct: 85  SGQVYSFGCNDEGALGRDTSVE----------GSEMVPGKVEL--------------QEK 120

Query: 332 VRDVACGANHTLVLDSQKRVFSWGF--GGYGRLGHAE-QKDEMVPRLVKL 378
           V  V+ G +HT  L    RVF WG      G +G  E  K  MVP  V+L
Sbjct: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL 170


>gi|114796640 regulator of chromosome condensation 1 [Homo sapiens]
          Length = 421

 Score =  104 bits (259), Expect = 2e-22
 Identities = 96/387 (24%), Positives = 170/387 (43%), Gaps = 27/387 (6%)

Query: 132 LGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVE 191
           LG+N+    +   L  +    V + +   H++ ++  G+++S+G N++G LG  DT  VE
Sbjct: 50  LGENVM-ERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGR-DTS-VE 106

Query: 192 APRLIEGLSH--EVIVSAACGRNHTLALTETGSVFAFGE--NKMGQLGLGNQTDAVPSPA 247
              ++ G     E +V  + G +HT ALT+ G VF +G   +  G +GL         P 
Sbjct: 107 GSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV 166

Query: 248 QIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCEL 307
           Q+  +  P+ K+A G +  +++   G+LY+ GC E GQLG   +  F  R  R   +  L
Sbjct: 167 QVQLD-VPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE-LFANRGGRQGLERLL 224

Query: 308 VPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQ 367
           VP+ V +   K++  +     +V  +D  CGA  T  +  +  V+ +G   Y +LG    
Sbjct: 225 VPKCVML---KSRGSR----GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGT 277

Query: 368 KDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR-------ESTMY 420
           +   +P+ +  F    +       G   +  +   G  +  G     R       E    
Sbjct: 278 ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSI 337

Query: 421 PKAVQDLCGWRIRSLACGKS-SIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVK 479
           P  +  L    + S+ACG S    V  D    +WG    + +LG G  +   S      K
Sbjct: 338 PTLISRLPA--VSSVACGASVGYAVTKDGRVFAWGMGTNY-QLGTGQDEDAWSPVEMMGK 394

Query: 480 TLDGIFSEQVAMGYSHSLVIARDESET 506
            L+      V+ G  H++++ +D+ ++
Sbjct: 395 QLENRVVLSVSSGGQHTVLLVKDKEQS 421



 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 48/170 (28%), Positives = 70/170 (41%), Gaps = 28/170 (16%)

Query: 212 NHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDC 271
           +H    TE G V   G+  +GQLGLG        PA +    + + +   G   ++ +  
Sbjct: 26  SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAGGMHTVCLSK 84

Query: 272 KGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVV 331
            G +YSFGC + G LG ++  +            E+VP +V +                 
Sbjct: 85  SGQVYSFGCNDEGALGRDTSVE----------GSEMVPGKVEL--------------QEK 120

Query: 332 VRDVACGANHTLVLDSQKRVFSWGF--GGYGRLGHAE-QKDEMVPRLVKL 378
           V  V+ G +HT  L    RVF WG      G +G  E  K  MVP  V+L
Sbjct: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL 170


>gi|114796648 regulator of chromosome condensation 1 [Homo sapiens]
          Length = 421

 Score =  104 bits (259), Expect = 2e-22
 Identities = 96/387 (24%), Positives = 170/387 (43%), Gaps = 27/387 (6%)

Query: 132 LGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVE 191
           LG+N+    +   L  +    V + +   H++ ++  G+++S+G N++G LG  DT  VE
Sbjct: 50  LGENVM-ERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGR-DTS-VE 106

Query: 192 APRLIEGLSH--EVIVSAACGRNHTLALTETGSVFAFGE--NKMGQLGLGNQTDAVPSPA 247
              ++ G     E +V  + G +HT ALT+ G VF +G   +  G +GL         P 
Sbjct: 107 GSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV 166

Query: 248 QIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCEL 307
           Q+  +  P+ K+A G +  +++   G+LY+ GC E GQLG   +  F  R  R   +  L
Sbjct: 167 QVQLD-VPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE-LFANRGGRQGLERLL 224

Query: 308 VPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQ 367
           VP+ V +   K++  +     +V  +D  CGA  T  +  +  V+ +G   Y +LG    
Sbjct: 225 VPKCVML---KSRGSR----GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGT 277

Query: 368 KDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR-------ESTMY 420
           +   +P+ +  F    +       G   +  +   G  +  G     R       E    
Sbjct: 278 ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSI 337

Query: 421 PKAVQDLCGWRIRSLACGKS-SIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVK 479
           P  +  L    + S+ACG S    V  D    +WG    + +LG G  +   S      K
Sbjct: 338 PTLISRLPA--VSSVACGASVGYAVTKDGRVFAWGMGTNY-QLGTGQDEDAWSPVEMMGK 394

Query: 480 TLDGIFSEQVAMGYSHSLVIARDESET 506
            L+      V+ G  H++++ +D+ ++
Sbjct: 395 QLENRVVLSVSSGGQHTVLLVKDKEQS 421



 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 48/170 (28%), Positives = 70/170 (41%), Gaps = 28/170 (16%)

Query: 212 NHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDC 271
           +H    TE G V   G+  +GQLGLG        PA +    + + +   G   ++ +  
Sbjct: 26  SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAGGMHTVCLSK 84

Query: 272 KGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVV 331
            G +YSFGC + G LG ++  +            E+VP +V +                 
Sbjct: 85  SGQVYSFGCNDEGALGRDTSVE----------GSEMVPGKVEL--------------QEK 120

Query: 332 VRDVACGANHTLVLDSQKRVFSWGF--GGYGRLGHAE-QKDEMVPRLVKL 378
           V  V+ G +HT  L    RVF WG      G +G  E  K  MVP  V+L
Sbjct: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL 170


>gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo
           sapiens]
          Length = 815

 Score = 97.4 bits (241), Expect = 3e-20
 Identities = 81/323 (25%), Positives = 143/323 (44%), Gaps = 40/323 (12%)

Query: 161 HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTET 220
           HS ++T   KL+ +G N  GQLG G    +  P  ++ L  E +  AACGRNHTL  TE 
Sbjct: 46  HSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEG 105

Query: 221 GSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQ-PITKMACGAEFSMIMDCKGNLYSFG 279
           G+V+A G N  GQLGLG+  +         +  +  I +++ G+  S  +   G L+ +G
Sbjct: 106 GNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWG 165

Query: 280 CPEYGQLG-----------HNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVP 328
               GQ+G             + GK ++      Y    V     +++    +   L +P
Sbjct: 166 DNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLP 225

Query: 329 NVV----------------VRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDE-M 371
           N +                V  VACG  HT+VL ++  V+++G G +G+LG      E  
Sbjct: 226 NQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVL-TENAVYTFGLGQFGQLGLGTFLFETS 284

Query: 372 VPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR--------ESTMYPKA 423
            P++++  +   +  S I  G   +  ++++G ++ +G     +         +   P  
Sbjct: 285 EPKVIE--NIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTL 342

Query: 424 VQDLCGWRIRSLACGKSSIIVAA 446
             +   + ++ +ACG   ++V A
Sbjct: 343 CSNFLRFIVKLVACGGCHMVVFA 365



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 72/311 (23%), Positives = 136/311 (43%), Gaps = 46/311 (14%)

Query: 201 HEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQI-MYNGQPITKM 259
           ++V V  +CG  H+  +T    ++ FG N  GQLGLG+++ A+  P  +     + +   
Sbjct: 34  NDVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKS-AISKPTCVKALKPEKVKLA 92

Query: 260 ACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKT 319
           ACG   +++    GN+Y+ G    GQLG           +R  +        ++ F  + 
Sbjct: 93  ACGRNHTLVSTEGGNVYATGGNNEGQLGLGD------TEERNTFHV------ISFFTSEH 140

Query: 320 KDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLF 379
           K           ++ ++ G+N +  L    R+F WG    G++G     +  VP+ V + 
Sbjct: 141 K-----------IKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI- 188

Query: 380 DFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR--------ESTMYPKAVQDLCGWR 431
              G+  S I  GY  S  V+  G L+ +G     +         +   P+ V ++   +
Sbjct: 189 ---GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEI-PEK 244

Query: 432 IRSLACGKSSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSE---Q 488
           +  +ACG    +V  + +  ++G    FG+LG G    ++S    E K ++ I  +    
Sbjct: 245 VIQVACGGEHTVVLTENAVYTFGLG-QFGQLGLGTFLFETS----EPKVIENIRDQTISY 299

Query: 489 VAMGYSHSLVI 499
           ++ G +H+ +I
Sbjct: 300 ISCGENHTALI 310



 Score = 72.4 bits (176), Expect = 9e-13
 Identities = 73/299 (24%), Positives = 123/299 (41%), Gaps = 58/299 (19%)

Query: 217 LTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLY 276
           + ++G+VF FG++K  +           +P +  +       ++CG E S ++     LY
Sbjct: 8   MPDSGAVFTFGKSKFAE----------NNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLY 57

Query: 277 SFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVA 336
            FG   +GQLG  S    I++   ++    L P +V +                     A
Sbjct: 58  MFGSNNWGQLGLGSKSA-ISKPTCVK---ALKPEKVKL--------------------AA 93

Query: 337 CGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCS 396
           CG NHTLV      V++ G    G+LG  + ++     ++  F    +   Q+ AG   S
Sbjct: 94  CGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHK-IKQLSAGSNTS 152

Query: 397 FAVSEVGGLFFWGATNTSRESTMYPKAVQDLC-------GWRIRSLACG-KSSIIVAADE 448
            A++E G LF WG    + E  +  K V ++C       G  +  ++CG   S  V  D 
Sbjct: 153 AALTEDGRLFMWG---DNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDG 209

Query: 449 STISWGPSPTFGELG-----YGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARD 502
               +G  P  G+LG      G+H+     +    K +      QVA G  H++V+  +
Sbjct: 210 ELYVFG-EPENGKLGLPNQLLGNHRTPQLVSEIPEKVI------QVACGGEHTVVLTEN 261


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
           sapiens]
          Length = 1152

 Score = 97.4 bits (241), Expect = 3e-20
 Identities = 81/323 (25%), Positives = 143/323 (44%), Gaps = 40/323 (12%)

Query: 161 HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTET 220
           HS ++T   KL+ +G N  GQLG G    +  P  ++ L  E +  AACGRNHTL  TE 
Sbjct: 46  HSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEG 105

Query: 221 GSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQ-PITKMACGAEFSMIMDCKGNLYSFG 279
           G+V+A G N  GQLGLG+  +         +  +  I +++ G+  S  +   G L+ +G
Sbjct: 106 GNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWG 165

Query: 280 CPEYGQLG-----------HNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVP 328
               GQ+G             + GK ++      Y    V     +++    +   L +P
Sbjct: 166 DNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLP 225

Query: 329 NVV----------------VRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDE-M 371
           N +                V  VACG  HT+VL ++  V+++G G +G+LG      E  
Sbjct: 226 NQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVL-TENAVYTFGLGQFGQLGLGTFLFETS 284

Query: 372 VPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR--------ESTMYPKA 423
            P++++  +   +  S I  G   +  ++++G ++ +G     +         +   P  
Sbjct: 285 EPKVIE--NIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTL 342

Query: 424 VQDLCGWRIRSLACGKSSIIVAA 446
             +   + ++ +ACG   ++V A
Sbjct: 343 CSNFLRFIVKLVACGGCHMVVFA 365



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 72/311 (23%), Positives = 136/311 (43%), Gaps = 46/311 (14%)

Query: 201 HEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQI-MYNGQPITKM 259
           ++V V  +CG  H+  +T    ++ FG N  GQLGLG+++ A+  P  +     + +   
Sbjct: 34  NDVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKS-AISKPTCVKALKPEKVKLA 92

Query: 260 ACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKT 319
           ACG   +++    GN+Y+ G    GQLG           +R  +        ++ F  + 
Sbjct: 93  ACGRNHTLVSTEGGNVYATGGNNEGQLGLGD------TEERNTFHV------ISFFTSEH 140

Query: 320 KDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLF 379
           K           ++ ++ G+N +  L    R+F WG    G++G     +  VP+ V + 
Sbjct: 141 K-----------IKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI- 188

Query: 380 DFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR--------ESTMYPKAVQDLCGWR 431
              G+  S I  GY  S  V+  G L+ +G     +         +   P+ V ++   +
Sbjct: 189 ---GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEI-PEK 244

Query: 432 IRSLACGKSSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSE---Q 488
           +  +ACG    +V  + +  ++G    FG+LG G    ++S    E K ++ I  +    
Sbjct: 245 VIQVACGGEHTVVLTENAVYTFGLG-QFGQLGLGTFLFETS----EPKVIENIRDQTISY 299

Query: 489 VAMGYSHSLVI 499
           ++ G +H+ +I
Sbjct: 300 ISCGENHTALI 310



 Score = 72.4 bits (176), Expect = 9e-13
 Identities = 73/299 (24%), Positives = 123/299 (41%), Gaps = 58/299 (19%)

Query: 217 LTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLY 276
           + ++G+VF FG++K  +           +P +  +       ++CG E S ++     LY
Sbjct: 8   MPDSGAVFTFGKSKFAE----------NNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLY 57

Query: 277 SFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVA 336
            FG   +GQLG  S    I++   ++    L P +V +                     A
Sbjct: 58  MFGSNNWGQLGLGSKSA-ISKPTCVK---ALKPEKVKL--------------------AA 93

Query: 337 CGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCS 396
           CG NHTLV      V++ G    G+LG  + ++     ++  F    +   Q+ AG   S
Sbjct: 94  CGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHK-IKQLSAGSNTS 152

Query: 397 FAVSEVGGLFFWGATNTSRESTMYPKAVQDLC-------GWRIRSLACG-KSSIIVAADE 448
            A++E G LF WG    + E  +  K V ++C       G  +  ++CG   S  V  D 
Sbjct: 153 AALTEDGRLFMWG---DNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDG 209

Query: 449 STISWGPSPTFGELG-----YGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARD 502
               +G  P  G+LG      G+H+     +    K +      QVA G  H++V+  +
Sbjct: 210 ELYVFG-EPENGKLGLPNQLLGNHRTPQLVSEIPEKVI------QVACGGEHTVVLTEN 261


>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
          Length = 979

 Score = 93.2 bits (230), Expect = 5e-19
 Identities = 82/337 (24%), Positives = 146/337 (43%), Gaps = 56/337 (16%)

Query: 146 AGVRVRTVVSGSCAAHSLLITTEGKLWSW-----GRNEKGQLGHGDTKRVEAPRLIEGLS 200
           +G   R V +G+   H  ++T E +L++W     G    GQLGHGD      P+ +E L 
Sbjct: 367 SGCSARQVCAGN--THFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQ 424

Query: 201 HEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQT-DAVPSPAQI-MYNGQPITK 258
            + I   +CG + T+ +T+ G ++AFG +  G +G+       V  P Q+  +   P+ +
Sbjct: 425 GKAIRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQ 484

Query: 259 MACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEK 318
           ++CG    +++     +YS+GC EYG+LG +S+  +    Q+++     VP+        
Sbjct: 485 VSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYT-PQKVD-----VPKA------- 531

Query: 319 TKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPR---- 374
                      +++  V CG + T +L    +V + G   + +LG  +    ++      
Sbjct: 532 -----------LIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYH 580

Query: 375 ---------LVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSREST-MYPKAV 424
                    L K   F       I  G T + A+ E G L  +G     +     Y K +
Sbjct: 581 EVPYTTSFTLAKQLSF--YKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRL 638

Query: 425 ------QDLCGWRIRSLACGKSSIIVAADESTI-SWG 454
                   L G ++  ++CG    I A D++ I +WG
Sbjct: 639 GINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWG 675



 Score = 73.6 bits (179), Expect = 4e-13
 Identities = 69/273 (25%), Positives = 109/273 (39%), Gaps = 47/273 (17%)

Query: 103 KGQLLIFGATNWDLIGRKEVPKQQAAYRNLGQNLWGPHRYGCLAGVRVRTVVSGSCAAHS 162
           +GQL  FG+  +  +G  +V          G  +  P +        V  V  G    H 
Sbjct: 444 EGQLYAFGSDYYGCMGVDKVA---------GPEVLEPMQLNFFLSNPVEQVSCGD--NHV 492

Query: 163 LLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGS 222
           +++T   +++SWG  E G+LG    +    P+ ++     +IV+  CG + T  LT++G 
Sbjct: 493 VVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGK 552

Query: 223 VFAFGENKMGQLGLGNQTDA---------VPSPAQIMYNGQ----PITKMACGAEFSMIM 269
           V A G N+  +LGL               VP         Q     I  +A G   +  +
Sbjct: 553 VLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAI 612

Query: 270 DCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPN 329
           D +G L +FGC + GQLG  +                   +R+ I +         P+  
Sbjct: 613 DERGRLLTFGCNKCGQLGVGN-----------------YKKRLGINLLGG------PLGG 649

Query: 330 VVVRDVACGANHTLVLDSQKRVFSWGFGGYGRL 362
             V  V+CG   T+       +F+WG GG GRL
Sbjct: 650 KQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRL 682



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 29/93 (31%), Positives = 51/93 (54%), Gaps = 3/93 (3%)

Query: 145 LAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEG-LSHEV 203
           L+  ++RT+  G    H+  I   G+L ++G N+ GQLG G+ K+     L+ G L  + 
Sbjct: 594 LSFYKIRTIAPGK--THTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQ 651

Query: 204 IVSAACGRNHTLALTETGSVFAFGENKMGQLGL 236
           ++  +CG   T+A T+   +FA+G    G+L +
Sbjct: 652 VIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAM 684



 Score = 34.7 bits (78), Expect = 0.22
 Identities = 33/132 (25%), Positives = 52/132 (39%), Gaps = 11/132 (8%)

Query: 383 GRGASQIYAGYTCSFAVSEVGGLFFW----GATNT-------SRESTMYPKAVQDLCGWR 431
           G  A Q+ AG T    V+    L+ W    G T          + S   PK V+ L G  
Sbjct: 368 GCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKA 427

Query: 432 IRSLACGKSSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAM 491
           IR ++CG    +   DE  +    S  +G +G             ++        EQV+ 
Sbjct: 428 IRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSC 487

Query: 492 GYSHSLVIARDE 503
           G +H +V+ R++
Sbjct: 488 GDNHVVVLTRNK 499



 Score = 34.3 bits (77), Expect = 0.28
 Identities = 35/124 (28%), Positives = 50/124 (40%), Gaps = 20/124 (16%)

Query: 103 KGQLLIFGATNWDLIGRKEVPKQQAAYRNLGQNLWGPHRYGCLAGVRVRTVVSGSCAAHS 162
           +G+LL FG      +G     K+      LG NL G    G L G +V  V  G     +
Sbjct: 615 RGRLLTFGCNKCGQLGVGNYKKR------LGINLLG----GPLGGKQVIRVSCGD--EFT 662

Query: 163 LLITTEGKLWSWGRNEKGQLG-------HGDTKRVEAPRLIEGLSHEVIVSAACGRNHTL 215
           +  T +  +++WG    G+L        HG       PR I G  H V    +C   HT+
Sbjct: 663 IAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFGSLHHV-PDLSCRGWHTI 721

Query: 216 ALTE 219
            + E
Sbjct: 722 LIVE 725


>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
          Length = 692

 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 102/405 (25%), Positives = 165/405 (40%), Gaps = 78/405 (19%)

Query: 35  KRERPERCSSSSGGGSSGDEDGLELDGAPGGGKRAARPATAGKA----GGAAVVITEPEH 90
           +  R E+  + S  GS      +   G P G  R A P          GG    +  P  
Sbjct: 273 RMRRAEKSVAPSNTGSR--TTSVRCRGIPRGPVRPAIPPPLSSVYAWGGGLGTPLRLPML 330

Query: 91  TKERVKLEGSKCK-------GQLLIF-----GATNWDLI-GRKEVPKQQAAYRNL-GQNL 136
             E V++   + +       G+L+++     GA    L+ G  E P+ Q   R L GQ+ 
Sbjct: 331 NTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLPGAVEQPQPQFISRFLEGQS- 389

Query: 137 WGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLI 196
                     GV ++ V  G     +  +T  G + ++G    G LGHG    +  P ++
Sbjct: 390 ----------GVTIKHVACGDF--FTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIV 437

Query: 197 EGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQI-MYNGQP 255
           E L    +V  ACG +H LAL+    +FA+G    G+LGLG + ++   P Q+ M  GQ 
Sbjct: 438 EALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTR-ESHSCPQQVPMPPGQE 496

Query: 256 ITKMACGAEFSMIMDCKGNLYSFGCPEYGQLG--HNSDGKFIARAQRIEYDCEL------ 307
             ++ CG + SMI+   G   + G   + +LG  H S G+     Q++E           
Sbjct: 497 AQRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSA 556

Query: 308 -VPRRVAIFIE----------------------------KTKDGQILP-----VPNVVVR 333
            + +   + I+                             T+ G   P     +  + + 
Sbjct: 557 PLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMA 616

Query: 334 DVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKL 378
            VACG   T+ + ++  V+SWG G  GRLG  ++ D  +PR V+L
Sbjct: 617 MVACGDAFTVAIGAESEVYSWGKGARGRLGRRDE-DAGLPRPVQL 660



 Score = 38.5 bits (88), Expect = 0.015
 Identities = 43/189 (22%), Positives = 80/189 (42%), Gaps = 19/189 (10%)

Query: 325 LPVPNVVVRDVACGANHTLVLDSQKRVFSW-----GFGGYGRLGHAEQKDEMVPRLVKLF 379
           LP+ N  V  VA G      +    R+  W     G GG   L  A ++ +  P+ +  F
Sbjct: 327 LPMLNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLPGAVEQPQ--PQFISRF 384

Query: 380 DFPGRGAS--QIYAGYTCSFAVSEVGGLFFWGATNT------SRESTMYPKAVQDLCGWR 431
                G +   +  G   +  +++ G +  +G+ +       S      P  V+ L G+ 
Sbjct: 385 LEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYE 444

Query: 432 IRSLACGKSSIIVAADESTI-SWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVA 490
           +  +ACG S ++  + E  + +WG   + G LG G    +S +  Q+V    G  +++V 
Sbjct: 445 MVQVACGASHVLALSTERELFAWGRGDS-GRLGLGTR--ESHSCPQQVPMPPGQEAQRVV 501

Query: 491 MGYSHSLVI 499
            G   S+++
Sbjct: 502 CGIDSSMIL 510


>gi|6912330 deafness locus associated putative guanine nucleotide
           exchange factor [Homo sapiens]
          Length = 458

 Score = 90.1 bits (222), Expect = 4e-18
 Identities = 94/394 (23%), Positives = 154/394 (39%), Gaps = 72/394 (18%)

Query: 171 LWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAAC-GRNHTLALTETGSVFAFGEN 229
           L++WG N  GQLG G  + V  P+ +        V     G  H+  +T+ G +F  G N
Sbjct: 17  LFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLN 76

Query: 230 KMGQLGLGNQTDAVP--SPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLG 287
           K GQLGLG+ T+ +P  +P + ++ G PI ++ACG +F++++   G + S G   +GQLG
Sbjct: 77  KDGQLGLGH-TEDIPYFTPCKSLF-GCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLG 134

Query: 288 HNSDGKFIARAQRIEYDCELV-----------------------------------PRRV 312
                +     Q IE   E V                                    + +
Sbjct: 135 VPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQTL 194

Query: 313 AIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMV 372
            +F    +  ++  + N     V  G++H+  L     V+ WG   +G+L + E     V
Sbjct: 195 PLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLAN-EAAFLPV 253

Query: 373 PRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATN-------------------- 412
           P+ ++   F     + I++G+T   A +E G +F WG  +                    
Sbjct: 254 PQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQD 313

Query: 413 ----TSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGELGY-GDH 467
                SR     P +   L G     ++CG    +        SWG    + E G  GD 
Sbjct: 314 SFLPCSRPPNSMPSSPHCLTG--ATEVSCGSEHNLAIIGGVCYSWG----WNEHGMCGDG 367

Query: 468 KPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIAR 501
              +  A + V+ L       V  G  HSL + +
Sbjct: 368 TEANVWAPKPVQALLSSSGLLVGCGAGHSLALCQ 401



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 35/126 (27%), Positives = 52/126 (41%), Gaps = 18/126 (14%)

Query: 104 GQLLIFGATNWDLIGRK-------EVPKQQA---AYRNLGQNLWGPHRYGCLAGVRVRTV 153
           G++  +G  ++  +GRK       ++ KQ +     R        PH   CL G      
Sbjct: 284 GKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPH---CLTGA----- 335

Query: 154 VSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNH 213
              SC +   L    G  +SWG NE G  G G    V AP+ ++ L     +   CG  H
Sbjct: 336 TEVSCGSEHNLAIIGGVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGH 395

Query: 214 TLALTE 219
           +LAL +
Sbjct: 396 SLALCQ 401


>gi|63054860 RCC1 domain containing 1 [Homo sapiens]
          Length = 376

 Score = 89.4 bits (220), Expect = 7e-18
 Identities = 64/229 (27%), Positives = 99/229 (43%), Gaps = 60/229 (26%)

Query: 159 AAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALT 218
           A H+LL+   G+++SWG    GQLGHG  +    PRL+E L   V+   A G  H++ ++
Sbjct: 167 AEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVS 226

Query: 219 ETGSVFAFGENKMGQLGL-----------------------------GNQTDAVPSPAQI 249
           ETG ++ +G N+ GQL L                             G   D  P+P   
Sbjct: 227 ETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIA 286

Query: 250 MY---------NGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQR 300
           +           G    K +CG+  + ++   G LY++G  +YGQLGH  D   + R +R
Sbjct: 287 VQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGH-EDTTSLDRPRR 345

Query: 301 IEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQK 349
           +EY           F++K           + V+ V CG  +T V   +K
Sbjct: 346 VEY-----------FVDK----------QLQVKAVTCGPWNTYVYAVEK 373



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 54/191 (28%), Positives = 83/191 (43%), Gaps = 28/191 (14%)

Query: 210 GRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIM 269
           G  H L L   G VF++G  + GQLG G     +         G  + ++A G   S+ +
Sbjct: 166 GAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCV 225

Query: 270 DCKGNLYSFGCPEYGQLGHNS-----DGKFIAR-AQRIEYDCELVPRRVAIFIEKTKDGQ 323
              G++Y +G  E GQL   +     DG+ +AR A  +  D   V R         +DG 
Sbjct: 226 SETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGG-----AEDGA 280

Query: 324 ILPVPNVVVRD---------------VACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQK 368
             P P + V+                 +CG+ HT V+     +++WG+G YG+LGH +  
Sbjct: 281 --PAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTT 338

Query: 369 DEMVPRLVKLF 379
               PR V+ F
Sbjct: 339 SLDRPRRVEYF 349



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 32/82 (39%), Positives = 48/82 (58%), Gaps = 2/82 (2%)

Query: 328 PNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGAS 387
           P +  R +  GA H L+LD+  +VFSWG G +G+LGH   + E+ PRL++     G   +
Sbjct: 156 PELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQ--GLVMA 213

Query: 388 QIYAGYTCSFAVSEVGGLFFWG 409
           ++ AG   S  VSE G ++ WG
Sbjct: 214 EVAAGGWHSVCVSETGDIYIWG 235



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 19/45 (42%), Positives = 30/45 (66%), Gaps = 1/45 (2%)

Query: 154 VSGSCAA-HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIE 197
           V  SC + H+ ++T  G+L++WG  + GQLGH DT  ++ PR +E
Sbjct: 303 VKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVE 347


>gi|63054858 RCC1 domain containing 1 [Homo sapiens]
          Length = 376

 Score = 89.4 bits (220), Expect = 7e-18
 Identities = 64/229 (27%), Positives = 99/229 (43%), Gaps = 60/229 (26%)

Query: 159 AAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALT 218
           A H+LL+   G+++SWG    GQLGHG  +    PRL+E L   V+   A G  H++ ++
Sbjct: 167 AEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVS 226

Query: 219 ETGSVFAFGENKMGQLGL-----------------------------GNQTDAVPSPAQI 249
           ETG ++ +G N+ GQL L                             G   D  P+P   
Sbjct: 227 ETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIA 286

Query: 250 MY---------NGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQR 300
           +           G    K +CG+  + ++   G LY++G  +YGQLGH  D   + R +R
Sbjct: 287 VQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGH-EDTTSLDRPRR 345

Query: 301 IEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQK 349
           +EY           F++K           + V+ V CG  +T V   +K
Sbjct: 346 VEY-----------FVDK----------QLQVKAVTCGPWNTYVYAVEK 373



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 54/191 (28%), Positives = 83/191 (43%), Gaps = 28/191 (14%)

Query: 210 GRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIM 269
           G  H L L   G VF++G  + GQLG G     +         G  + ++A G   S+ +
Sbjct: 166 GAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCV 225

Query: 270 DCKGNLYSFGCPEYGQLGHNS-----DGKFIAR-AQRIEYDCELVPRRVAIFIEKTKDGQ 323
              G++Y +G  E GQL   +     DG+ +AR A  +  D   V R         +DG 
Sbjct: 226 SETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGG-----AEDGA 280

Query: 324 ILPVPNVVVRD---------------VACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQK 368
             P P + V+                 +CG+ HT V+     +++WG+G YG+LGH +  
Sbjct: 281 --PAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTT 338

Query: 369 DEMVPRLVKLF 379
               PR V+ F
Sbjct: 339 SLDRPRRVEYF 349



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 32/82 (39%), Positives = 48/82 (58%), Gaps = 2/82 (2%)

Query: 328 PNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGAS 387
           P +  R +  GA H L+LD+  +VFSWG G +G+LGH   + E+ PRL++     G   +
Sbjct: 156 PELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQ--GLVMA 213

Query: 388 QIYAGYTCSFAVSEVGGLFFWG 409
           ++ AG   S  VSE G ++ WG
Sbjct: 214 EVAAGGWHSVCVSETGDIYIWG 235



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 19/45 (42%), Positives = 30/45 (66%), Gaps = 1/45 (2%)

Query: 154 VSGSCAA-HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIE 197
           V  SC + H+ ++T  G+L++WG  + GQLGH DT  ++ PR +E
Sbjct: 303 VKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVE 347


>gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo
           sapiens]
          Length = 464

 Score = 79.3 bits (194), Expect = 8e-15
 Identities = 82/305 (26%), Positives = 125/305 (40%), Gaps = 50/305 (16%)

Query: 204 IVSAACGRNHTLALTETG---SVFAFGENKMGQLGL---------GNQTDAVPSPAQIMY 251
           I SAACG   TL  ++T     V+  G NK  QLG          G +    PSP  +  
Sbjct: 109 ISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPL 168

Query: 252 NGQPITK---MACGAEFSMIMDCKGNLYSFGCPEYGQLGHN-SDGKFIARAQRIEYDCEL 307
           +    T+   ++CG   S+++  +  ++S G   YGQ G    + +  + + R+      
Sbjct: 169 DRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRV------ 222

Query: 308 VPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQ 367
              R+  F     DGQ++         VACG +H+L L  +  V+S G+G  G+ G    
Sbjct: 223 --HRMQDF-----DGQVV--------QVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHY 267

Query: 368 KDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWG-------ATNTSRESTMY 420
                P  +   D  G    Q+     C  AVS  GGLF WG       A+ T       
Sbjct: 268 NITSSPTKLG-GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNV 326

Query: 421 PKAVQDLCGWRIRSLACGKSSIIVAADESTI-SWGPSPTFGELGYGDHKPKSSTAAQEVK 479
           P+ +      ++R  ACG +   V   E  +  WG    +G LG G +  +S+       
Sbjct: 327 PRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG----YGILGKGPNLVESAVPEMIPP 382

Query: 480 TLDGI 484
           TL G+
Sbjct: 383 TLFGL 387



 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 73/292 (25%), Positives = 117/292 (40%), Gaps = 54/292 (18%)

Query: 170 KLWSWGRNEKGQLGHGDTKR--------------VEAPRLIEGLSHEVIVSAACGRNHTL 215
           K+W  G N+  QLG   +++              V  P  ++      ++  +CGR H+L
Sbjct: 130 KVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLP--LDRPQETRVLQVSCGRAHSL 187

Query: 216 ALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQ----PITKMACGAEFSMIMDC 271
            LT+   VF+ G N  GQ G     + + S +  ++  Q     + ++ACG + S+ +  
Sbjct: 188 VLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTD 247

Query: 272 KGNLYSFGCPEYGQ--------------LGHNSDGKFIARAQRIEYDCELVPRRVAIF-- 315
           KG +YS G    GQ              LG +  G  + +       C  V     +F  
Sbjct: 248 KGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGW 307

Query: 316 -------IEKTKDGQILPVPNVV-------VRDVACGANHTLVLDSQKRVFSWGFGGYGR 361
                  +    D   + VP  +       VR  ACG     VL+ +  VF WG+G  G+
Sbjct: 308 GNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGK 367

Query: 362 ---LGHAEQKDEMVPRLVKLFDF-PGRGASQIYAGYTCSFAVSEVGGLFFWG 409
              L  +   + + P L  L +F P    S+I  G +   A++  G LF WG
Sbjct: 368 GPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWG 419



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 64/267 (23%), Positives = 111/267 (41%), Gaps = 51/267 (19%)

Query: 153 VVSGSCA-AHSLLITTEGKLWSWGRNEKGQLG--------HGDTKRVEAPRLIEGLSHEV 203
           V+  SC  AHSL++T    ++S G N  GQ G        + ++ RV   +  +G     
Sbjct: 176 VLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ---- 231

Query: 204 IVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYN--GQPITKMAC 261
           +V  ACG++H+L LT+ G V++ G    GQ GLG+  +   SP ++  +  G  + ++A 
Sbjct: 232 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHY-NITSSPTKLGGDLAGVNVIQVAT 290

Query: 262 GAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYD--------------CEL 307
             +  + +   G L+ +G  EY QL   +D   +   + + +               C +
Sbjct: 291 YGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAV 350

Query: 308 VPRRVAIFI-------------EKTKDGQILPV--------PNVVVRDVACGANHTLVLD 346
           +     +F+             E      I P         P + V  + CG +H   L 
Sbjct: 351 LNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALT 410

Query: 347 SQKRVFSWGFGGYGRLGHAEQKDEMVP 373
           ++  +F WG    G LG    +D+  P
Sbjct: 411 NKGELFVWGKNIRGCLGIGRLEDQYFP 437



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 55/217 (25%), Positives = 99/217 (45%), Gaps = 27/217 (12%)

Query: 254 QPITKMACGAEFSMIMDCKGNL---YSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPR 310
           Q I+  ACG  F+++     ++   +  G  +  QLG +   K   R     Y+  L P 
Sbjct: 107 QKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRG----YEYVLEPS 162

Query: 311 RVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDE 370
            V++ +++ ++ ++L         V+CG  H+LVL  ++ VFS G   YG+ G    ++E
Sbjct: 163 PVSLPLDRPQETRVL--------QVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENE 214

Query: 371 MVP---RLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFF--WGATNTS-----RESTMY 420
           +     R+ ++ DF G+   Q+  G   S  +++ G ++   WGA   +       ++  
Sbjct: 215 IYSESHRVHRMQDFDGQ-VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSP 273

Query: 421 PKAVQDLCGWRIRSLAC-GKSSIIVAADESTISWGPS 456
            K   DL G  +  +A  G   + V+AD     WG S
Sbjct: 274 TKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNS 310



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 62/212 (29%), Positives = 90/212 (42%), Gaps = 39/212 (18%)

Query: 143 GCLAGVRVRTVVS-GSCAAHSLLITTEGKLWSWGRNEKGQLGH-GDTKRVEAPRLIEGLS 200
           G LAGV V  V + G C    L ++ +G L+ WG +E  QL    D+ +V  PR +    
Sbjct: 278 GDLAGVNVIQVATYGDCC---LAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSG 334

Query: 201 HEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPS--PAQIM----YNGQ 254
              +  AACG      L   G VF +G   +G+ G      AVP   P  +     +N +
Sbjct: 335 VGKVRQAACGGTGCAVLNGEGHVFVWGYGILGK-GPNLVESAVPEMIPPTLFGLTEFNPE 393

Query: 255 -PITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVA 313
             ++++ CG      +  KG L+ +G    G LG       I R +      +  P RV 
Sbjct: 394 IQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLG-------IGRLED-----QYFPWRV- 440

Query: 314 IFIEKTKDGQILPVPNVVVRDVACGANHTLVL 345
                T  G+  PV      DVACG +H + L
Sbjct: 441 -----TMPGE--PV------DVACGVDHMVTL 459


>gi|57863304 inhibitor of Bruton's tyrosine kinase [Homo sapiens]
          Length = 1353

 Score = 79.3 bits (194), Expect = 8e-15
 Identities = 79/290 (27%), Positives = 131/290 (45%), Gaps = 37/290 (12%)

Query: 146 AGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIV 205
           +G+ ++ VV   C  HS+ ++ +G++++ G    G+LGHGD +    PRL+EGL+     
Sbjct: 175 SGIYIKQVVL--CKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCS 232

Query: 206 SAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIM---YNGQPITKMACG 262
             A  ++HT+ LTE G V+ FG N   QLG+     +   P QI      G+ I  +A G
Sbjct: 233 QVAAAKDHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAG 292

Query: 263 AEFSMIMDCKGNLYSFGCPEYGQLG--HNSDGKFIARAQRIEYDCELVPRRVAIFIEKTK 320
             F  ++  +  +Y+ G    GQLG   + +G+    A R      L  + +A+ +    
Sbjct: 293 -RFHTVLWTREAVYTMGL-NGGQLGCLLDPNGEKCVTAPR--QVSALHHKDIALSLVAAS 348

Query: 321 DGQILPVPN----VVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLV 376
           DG  + V       ++ D  C    +  L+ +K + S         GH E K +  P  +
Sbjct: 349 DGATVCVTTRGDIYLLADYQCKKMASKQLNLKKVLVSG--------GHMEYKVD--PEHL 398

Query: 377 KLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSREST--MYPKAV 424
           K       G  +I     C  A+   G +F W + N+S +     YP+ V
Sbjct: 399 K-----ENGGQKI-----CILAMDGAGRVFCWRSVNSSLKQCRWAYPRQV 438



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 49/196 (25%), Positives = 89/196 (45%), Gaps = 27/196 (13%)

Query: 171 LWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHE--VIVSAACGRNHTLALTETGSVFAFGE 228
           +++WG N    LGHG       P L++  S     I      + H++ L++ G V+  G 
Sbjct: 144 VYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGH 203

Query: 229 NKMGQLGLGN-QTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLG 287
              G+LG G+ QT  VP   + + NG   +++A   + ++++   G +Y+FG   + QLG
Sbjct: 204 GPGGRLGHGDEQTCLVPRLVEGL-NGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLG 262

Query: 288 HNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDS 347
                              ++P   +  + +    + L    ++   VA G  HT VL +
Sbjct: 263 -------------------IIPPPSSCNVPRQIQAKYLKGRTII--GVAAGRFHT-VLWT 300

Query: 348 QKRVFSWGFGGYGRLG 363
           ++ V++ G  G G+LG
Sbjct: 301 REAVYTMGLNG-GQLG 315



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 38/159 (23%), Positives = 63/159 (39%), Gaps = 7/159 (4%)

Query: 351 VFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGA 410
           V++WG      LGH  Q  +  P LV LF   G    Q+      S  +S+ G ++  G 
Sbjct: 144 VYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGH 203

Query: 411 TNTSR------ESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGELGY 464
               R      ++ + P+ V+ L G     +A  K   +V  ++  +       F +LG 
Sbjct: 204 GPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGI 263

Query: 465 GDHKPKSSTAAQ-EVKTLDGIFSEQVAMGYSHSLVIARD 502
                  +   Q + K L G     VA G  H+++  R+
Sbjct: 264 IPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTRE 302


>gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo
           sapiens]
          Length = 596

 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 43/112 (38%), Positives = 65/112 (58%), Gaps = 3/112 (2%)

Query: 158 CAAHSLL-ITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLA 216
           C A  LL +T  G +W+WG+ +  +LGH     V  P+++EGL  + IV  A G  H LA
Sbjct: 63  CGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLA 122

Query: 217 LTETGSVFAFGENKMGQLGLGNQT-DAVPSPAQIMYNGQPITKMACGAEFSM 267
           + ++G V+A+G+N  GQ G G  T +  P+  Q +  GQ I  +ACG+  S+
Sbjct: 123 VMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGL-EGQKIMCVACGSSHSV 173



 Score = 63.2 bits (152), Expect = 6e-10
 Identities = 37/125 (29%), Positives = 68/125 (54%), Gaps = 4/125 (3%)

Query: 168 EGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFG 227
           E  ++SWG  + G+LG G ++    P+ IE L+ + +    CG    LALT++G V+ +G
Sbjct: 22  ESLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWG 81

Query: 228 ENKMGQLGLGNQTDAVPSPAQIM--YNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQ 285
             K     LG+++D      Q++    G+ I  +A GA+  + +   G +Y++G  ++GQ
Sbjct: 82  --KGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQ 139

Query: 286 LGHNS 290
            G+ +
Sbjct: 140 QGNGT 144



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 67/284 (23%), Positives = 123/284 (43%), Gaps = 50/284 (17%)

Query: 223 VFAFGENKMGQLGLGNQTDA-VPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCP 281
           VF++G+   G+LG G      +P   + + NGQ + ++ CGA+F + +   G ++++G  
Sbjct: 25  VFSWGDGDFGKLGRGGSEGCNIPQNIERL-NGQGVCQIECGAQFLLALTKSGVVWTWGKG 83

Query: 282 EYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANH 341
           +Y +LGH SD                V  R    +E  +  +I+         VA GA H
Sbjct: 84  DYFRLGHRSD----------------VHVRKPQVVEGLRGKKIV--------HVAVGAQH 119

Query: 342 TLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSE 401
            L +    +V++WG   +G+ G+        P LV+     G+    +  G + S A + 
Sbjct: 120 CLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQ--GLEGQKIMCVACGSSHSVAWTT 177

Query: 402 VGGLFFWGATNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGE 461
           V       AT +  E  ++  A   L          G S + V +D ++ +     +   
Sbjct: 178 VD-----VATPSVHEPVLFQTARDPL----------GASYLGVPSDVNSSAASNKIS--- 219

Query: 462 LGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGY---SHSLVIARD 502
            G  + KP   + A+ + +LDG  ++Q A+ +   +  ++ ARD
Sbjct: 220 -GASNSKPYHPSLAKILLSLDGNLAKQQALSHILTALQIMYARD 262



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 41/139 (29%), Positives = 68/139 (48%), Gaps = 10/139 (7%)

Query: 147 GVRVRTVVSGSCAA-HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIV 205
           G+R + +V  +  A H L +   G++++WG N+ GQ G+G T     P L++GL  + I+
Sbjct: 104 GLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKIM 163

Query: 206 SAACGRNHTLALT----ETGSV-----FAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPI 256
             ACG +H++A T     T SV     F    + +G   LG  +D   S A    +G   
Sbjct: 164 CVACGSSHSVAWTTVDVATPSVHEPVLFQTARDPLGASYLGVPSDVNSSAASNKISGASN 223

Query: 257 TKMACGAEFSMIMDCKGNL 275
           +K    +   +++   GNL
Sbjct: 224 SKPYHPSLAKILLSLDGNL 242


>gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo
           sapiens]
          Length = 1052

 Score = 75.9 bits (185), Expect = 9e-14
 Identities = 43/112 (38%), Positives = 64/112 (57%), Gaps = 3/112 (2%)

Query: 158 CAAHSLL-ITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLA 216
           C A  LL +T  G +W+WG+ +  +LGH     V  P+++EGL  + IV  A G  H LA
Sbjct: 715 CGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLA 774

Query: 217 LTETGSVFAFGENKMGQLGLGNQT-DAVPSPAQIMYNGQPITKMACGAEFSM 267
           + ++G V+A+G+N  GQ G G  T +  P   Q +  GQ I  +ACG+  S+
Sbjct: 775 VMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQGL-EGQKIMCVACGSSHSV 825



 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 37/124 (29%), Positives = 68/124 (54%), Gaps = 4/124 (3%)

Query: 169 GKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGE 228
           G ++SWG  + G+LG G ++    P+ IE L+ + +    CG    LALT++G V+ +G 
Sbjct: 675 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWG- 733

Query: 229 NKMGQLGLGNQTDAVPSPAQIM--YNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQL 286
            K     LG+++D      Q++    G+ I  +A GA+  + +   G +Y++G  ++GQ 
Sbjct: 734 -KGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQ 792

Query: 287 GHNS 290
           G+ +
Sbjct: 793 GNGT 796



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 67/286 (23%), Positives = 118/286 (41%), Gaps = 50/286 (17%)

Query: 221 GSVFAFGENKMGQLGLGNQTDA-VPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFG 279
           G VF++G+   G+LG G      +P   + + NGQ + ++ CGA+F + +   G ++++G
Sbjct: 675 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERL-NGQGVCQIECGAQFLLALTKSGVVWTWG 733

Query: 280 CPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGA 339
             +Y +LGH SD                V  R    +E  +  +I+         VA GA
Sbjct: 734 KGDYFRLGHRSD----------------VHVRKPQVVEGLRGKKIV--------HVAVGA 769

Query: 340 NHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAV 399
            H L +    +V++WG   +G+ G+        P LV+     G+    +  G + S A 
Sbjct: 770 QHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQ--GLEGQKIMCVACGSSHSVA- 826

Query: 400 SEVGGLFFWGATNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTF 459
                   W   + +  S   P   Q        S     S +  +A  + IS       
Sbjct: 827 --------WTTMDVATPSVHEPVLFQTARDPLGASYLGVPSDVNSSAASNKIS------- 871

Query: 460 GELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGY---SHSLVIARD 502
              G  + KP   + A+ + +LDG  ++Q A+ +   +  ++ ARD
Sbjct: 872 ---GASNSKPYHPSLAKILLSLDGNLAKQQALSHILTALQIMYARD 914



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 41/139 (29%), Positives = 68/139 (48%), Gaps = 10/139 (7%)

Query: 147 GVRVRTVVSGSCAA-HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIV 205
           G+R + +V  +  A H L +   G++++WG N+ GQ G+G T     P L++GL  + I+
Sbjct: 756 GLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQGLEGQKIM 815

Query: 206 SAACGRNHTLALT----ETGSV-----FAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPI 256
             ACG +H++A T     T SV     F    + +G   LG  +D   S A    +G   
Sbjct: 816 CVACGSSHSVAWTTMDVATPSVHEPVLFQTARDPLGASYLGVPSDVNSSAASNKISGASN 875

Query: 257 TKMACGAEFSMIMDCKGNL 275
           +K    +   +++   GNL
Sbjct: 876 SKPYHPSLAKILLSLDGNL 894


>gi|40316935 alsin isoform 1 [Homo sapiens]
          Length = 1657

 Score = 72.4 bits (176), Expect = 9e-13
 Identities = 46/141 (32%), Positives = 75/141 (53%), Gaps = 8/141 (5%)

Query: 146 AGVRVRTVV---SGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHE 202
           A V+ RTVV   + S  A +LL +   ++W+WG+ ++GQLGHGD      P  ++ L  +
Sbjct: 500 ARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGK 559

Query: 203 VIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACG 262
            ++    G  H+LALT    V+++G N  GQLG  +    VP  A+I  +   +  +A G
Sbjct: 560 EVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDFPTTVPRLAKIS-SENGVWSIAAG 618

Query: 263 AEFSMIM----DCKGNLYSFG 279
            ++S+ +    D +  LY  G
Sbjct: 619 RDYSLFLVDTEDFQPGLYYSG 639



 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 39/156 (25%), Positives = 71/156 (45%), Gaps = 17/156 (10%)

Query: 185 GDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGS-------------VFAFGENKM 231
           G ++R+  P L+  +S  ++  AA  +  T+ LT T S             V+ +G+ K 
Sbjct: 477 GGSRRLSLPGLLSQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKE 536

Query: 232 GQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSD 291
           GQLG G+    +        +G+ +  +  G   S+ +  K  +YS+G   +GQLGH+  
Sbjct: 537 GQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDF 596

Query: 292 GKFIARAQRIEYDCEL----VPRRVAIFIEKTKDGQ 323
              + R  +I  +  +      R  ++F+  T+D Q
Sbjct: 597 PTTVPRLAKISSENGVWSIAAGRDYSLFLVDTEDFQ 632



 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 51/214 (23%), Positives = 93/214 (43%), Gaps = 45/214 (21%)

Query: 145 LAGVRVRTVVSGSCAA-HSLLITTEGKLWSWG----RNEKGQLGHGDTKRVEAPRLIEGL 199
           L G   +TV+  +    H +L+T +G+++S+G    R+   ++         +P L   L
Sbjct: 35  LPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPS------SPILENAL 88

Query: 200 SHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQP---- 255
             + +++ A G  H+ A+T+ G  + +GEN  GQ  + NQ   VP P  +          
Sbjct: 89  VGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQ-QYVPEPNPVSIADSEASPL 147

Query: 256 ----ITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRR 311
               I ++ACG E ++ +     ++++G     QLG  +    + + Q++E+        
Sbjct: 148 LAVRILQLACGEEHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEH-------- 197

Query: 312 VAIFIEKTKDGQILPVPNVVVRDVACGANHTLVL 345
                          +   VV  VACGA H+L L
Sbjct: 198 ---------------LAGRVVLQVACGAFHSLAL 216



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 46/168 (27%), Positives = 72/168 (42%), Gaps = 25/168 (14%)

Query: 193 PRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYN 252
           P  + G   + ++ AA G  H + LTE G V++FG             +  PS + I+ N
Sbjct: 32  PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRS----GPVEICPS-SPILEN 86

Query: 253 ---GQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVP 309
              GQ +  +A G+  S  +   G  Y +G         NS G+     Q  +Y  E  P
Sbjct: 87  ALVGQYVITVATGSFHSGAVTDNGVAYMWG--------ENSAGQCAVANQ--QYVPEPNP 136

Query: 310 RRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFG 357
             +A       D +  P+  V +  +ACG  HTL L   + +++WG G
Sbjct: 137 VSIA-------DSEASPLLAVRILQLACGEEHTLALSISREIWAWGTG 177



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 31/123 (25%), Positives = 58/123 (47%), Gaps = 25/123 (20%)

Query: 256 ITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIF 315
           +T    G   +++   +  ++++G  + GQLGH                 +++PR   + 
Sbjct: 509 LTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHG----------------DVLPRLQPLC 552

Query: 316 IEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRL 375
           + K  DG+        V  +  G  H+L L ++ +V+SWG   +G+LGH++     VPRL
Sbjct: 553 V-KCLDGK-------EVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSD-FPTTVPRL 603

Query: 376 VKL 378
            K+
Sbjct: 604 AKI 606



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 25/76 (32%), Positives = 40/76 (52%), Gaps = 5/76 (6%)

Query: 145 LAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTK-RVEAPRLIEGLSHEV 203
           L  VR+  +  G    H+L ++   ++W+WG     QLG   T   V  P+ +E L+  V
Sbjct: 147 LLAVRILQLACGE--EHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEHLAGRV 202

Query: 204 IVSAACGRNHTLALTE 219
           ++  ACG  H+LAL +
Sbjct: 203 VLQVACGAFHSLALVQ 218



 Score = 38.5 bits (88), Expect = 0.015
 Identities = 40/173 (23%), Positives = 61/173 (35%), Gaps = 49/173 (28%)

Query: 330 VVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQI 389
           VV+     G    L+   +  V++WG G  G+LGH +    + P  VK  D  G+    +
Sbjct: 507 VVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLD--GKEVIHL 564

Query: 390 YAGYTCSFAVSEVGGLFFWGATNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADES 449
            AG                                             G  S+ + A   
Sbjct: 565 EAG---------------------------------------------GYHSLALTAKSQ 579

Query: 450 TISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARD 502
             SWG S TFG+LG+ D  P +     ++ + +G++S      YS  LV   D
Sbjct: 580 VYSWG-SNTFGQLGHSDF-PTTVPRLAKISSENGVWSIAAGRDYSLFLVDTED 630



 Score = 32.0 bits (71), Expect = 1.4
 Identities = 49/200 (24%), Positives = 77/200 (38%), Gaps = 27/200 (13%)

Query: 332 VRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFD-FPGRGASQIY 390
           V   A G  H ++L     V+S     +G L       E+ P    L +   G+    + 
Sbjct: 43  VLQAALGVKHGVLLTEDGEVYS-----FGTLPWRSGPVEICPSSPILENALVGQYVITVA 97

Query: 391 AGYTCSFAVSEVGGLFFWGATNTSR---ESTMY-----PKAVQD-----LCGWRIRSLAC 437
            G   S AV++ G  + WG  +  +    +  Y     P ++ D     L   RI  LAC
Sbjct: 98  TGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLAC 157

Query: 438 GKSSIIVAADESTI-SWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHS 496
           G+   +  +    I +WG     G +          T  Q+V+ L G    QVA G  HS
Sbjct: 158 GEEHTLALSISREIWAWGTGCQLGLITTAF----PVTKPQKVEHLAGRVVLQVACGAFHS 213

Query: 497 LVIARDESETEKEKIKKLPE 516
           L + +       + +K +PE
Sbjct: 214 LALVQC---LPSQDLKPVPE 230


>gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo
           sapiens]
          Length = 1102

 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 42/112 (37%), Positives = 63/112 (56%), Gaps = 3/112 (2%)

Query: 158 CAAHSLL-ITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLA 216
           C A  LL +T  G +W+WG+ +  +LGH     V   +++EGL  + IV  A G  H LA
Sbjct: 765 CGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLA 824

Query: 217 LTETGSVFAFGENKMGQLGLGNQT-DAVPSPAQIMYNGQPITKMACGAEFSM 267
           + ++G V+A+G+N  GQ G G  T +  P   Q +  GQ I  +ACG+  S+
Sbjct: 825 VMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQGL-EGQKIMCVACGSSHSV 875



 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 37/124 (29%), Positives = 68/124 (54%), Gaps = 4/124 (3%)

Query: 169 GKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGE 228
           G ++SWG  + G+LG G ++    P+ IE L+ + +    CG    LALT++G V+ +G 
Sbjct: 725 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWG- 783

Query: 229 NKMGQLGLGNQTDAVPSPAQIM--YNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQL 286
            K     LG+++D      Q++    G+ I  +A GA+  + +   G +Y++G  ++GQ 
Sbjct: 784 -KGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQ 842

Query: 287 GHNS 290
           G+ +
Sbjct: 843 GNGT 846



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 67/286 (23%), Positives = 118/286 (41%), Gaps = 50/286 (17%)

Query: 221 GSVFAFGENKMGQLGLGNQTDA-VPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFG 279
           G VF++G+   G+LG G      +P   + + NGQ + ++ CGA+F + +   G ++++G
Sbjct: 725 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERL-NGQGVCQIECGAQFLLALTKSGVVWTWG 783

Query: 280 CPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGA 339
             +Y +LGH SD                V  R    +E  +  +I+         VA GA
Sbjct: 784 KGDYFRLGHRSD----------------VHVRKLQVVEGLRGKKIV--------HVAVGA 819

Query: 340 NHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAV 399
            H L +    +V++WG   +G+ G+        P LV+     G+    +  G + S A 
Sbjct: 820 QHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQ--GLEGQKIMCVACGSSHSVA- 876

Query: 400 SEVGGLFFWGATNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTF 459
                   W   + +  S   P   Q        S     S +  +A  + IS       
Sbjct: 877 --------WTTMDVATPSVHEPVLFQTARDPLGASYLGVPSDVNSSAASNKIS------- 921

Query: 460 GELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGY---SHSLVIARD 502
              G  + KP   + A+ + +LDG  ++Q A+ +   +  ++ ARD
Sbjct: 922 ---GASNSKPYHPSLAKILLSLDGNLAKQQALSHILTALQIMYARD 964



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 41/139 (29%), Positives = 68/139 (48%), Gaps = 10/139 (7%)

Query: 147 GVRVRTVVSGSCAA-HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIV 205
           G+R + +V  +  A H L +   G++++WG N+ GQ G+G T     P L++GL  + I+
Sbjct: 806 GLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQGLEGQKIM 865

Query: 206 SAACGRNHTLALT----ETGSV-----FAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPI 256
             ACG +H++A T     T SV     F    + +G   LG  +D   S A    +G   
Sbjct: 866 CVACGSSHSVAWTTMDVATPSVHEPVLFQTARDPLGASYLGVPSDVNSSAASNKISGASN 925

Query: 257 TKMACGAEFSMIMDCKGNL 275
           +K    +   +++   GNL
Sbjct: 926 SKPYHPSLAKILLSLDGNL 944


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.134    0.410 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,972,699
Number of Sequences: 37866
Number of extensions: 1078622
Number of successful extensions: 5900
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 63
Number of HSP's successfully gapped in prelim test: 145
Number of HSP's that attempted gapping in prelim test: 4772
Number of HSP's gapped (non-prelim): 743
length of query: 522
length of database: 18,247,518
effective HSP length: 107
effective length of query: 415
effective length of database: 14,195,856
effective search space: 5891280240
effective search space used: 5891280240
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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