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Search of human proteins with 29789090
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|29789090 regulator of chromosome condensation 2 [Homo
sapiens]
(522 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|209969703 regulator of chromosome condensation 2 [Homo sapiens] 1070 0.0
gi|29789090 regulator of chromosome condensation 2 [Homo sapiens] 1070 0.0
gi|126032348 hect domain and RLD 2 [Homo sapiens] 130 2e-30
gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens] 130 3e-30
gi|7657152 hect domain and RLD 3 [Homo sapiens] 124 2e-28
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 120 4e-27
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens] 120 4e-27
gi|4557445 regulator of chromosome condensation and BTB domain c... 118 1e-26
gi|57242759 regulator of chromosome condensation (RCC1) and BTB ... 113 4e-25
gi|110825982 hect domain and RLD 5 [Homo sapiens] 111 1e-24
gi|61563742 hect domain and RLD 6 [Homo sapiens] 106 6e-23
gi|114796646 regulator of chromosome condensation 1 isoform b [H... 104 2e-22
gi|114796644 regulator of chromosome condensation 1 isoform a [H... 104 2e-22
gi|4502801 regulator of chromosome condensation 1 isoform c [Hom... 104 2e-22
gi|114796642 regulator of chromosome condensation 1 [Homo sapiens] 104 2e-22
gi|114796640 regulator of chromosome condensation 1 [Homo sapiens] 104 2e-22
gi|114796648 regulator of chromosome condensation 1 [Homo sapiens] 104 2e-22
gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo... 97 3e-20
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 97 3e-20
gi|222136641 NIMA-related kinase 9 [Homo sapiens] 93 5e-19
gi|30039692 NIMA-related kinase 8 [Homo sapiens] 91 3e-18
gi|6912330 deafness locus associated putative guanine nucleotide... 90 4e-18
gi|63054860 RCC1 domain containing 1 [Homo sapiens] 89 7e-18
gi|63054858 RCC1 domain containing 1 [Homo sapiens] 89 7e-18
gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo ... 79 8e-15
gi|57863304 inhibitor of Bruton's tyrosine kinase [Homo sapiens] 79 8e-15
gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo ... 77 5e-14
gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo s... 76 9e-14
gi|40316935 alsin isoform 1 [Homo sapiens] 72 9e-13
gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo s... 72 1e-12
>gi|209969703 regulator of chromosome condensation 2 [Homo sapiens]
Length = 522
Score = 1070 bits (2767), Expect = 0.0
Identities = 522/522 (100%), Positives = 522/522 (100%)
Query: 1 MPRKKAAAAAWEEPSSGNGTARAGPRKRGGPAGRKRERPERCSSSSGGGSSGDEDGLELD 60
MPRKKAAAAAWEEPSSGNGTARAGPRKRGGPAGRKRERPERCSSSSGGGSSGDEDGLELD
Sbjct: 1 MPRKKAAAAAWEEPSSGNGTARAGPRKRGGPAGRKRERPERCSSSSGGGSSGDEDGLELD 60
Query: 61 GAPGGGKRAARPATAGKAGGAAVVITEPEHTKERVKLEGSKCKGQLLIFGATNWDLIGRK 120
GAPGGGKRAARPATAGKAGGAAVVITEPEHTKERVKLEGSKCKGQLLIFGATNWDLIGRK
Sbjct: 61 GAPGGGKRAARPATAGKAGGAAVVITEPEHTKERVKLEGSKCKGQLLIFGATNWDLIGRK 120
Query: 121 EVPKQQAAYRNLGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKG 180
EVPKQQAAYRNLGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKG
Sbjct: 121 EVPKQQAAYRNLGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKG 180
Query: 181 QLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQT 240
QLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQT
Sbjct: 181 QLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQT 240
Query: 241 DAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQR 300
DAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQR
Sbjct: 241 DAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQR 300
Query: 301 IEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYG 360
IEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYG
Sbjct: 301 IEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYG 360
Query: 361 RLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSRESTMY 420
RLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSRESTMY
Sbjct: 361 RLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSRESTMY 420
Query: 421 PKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKT 480
PKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKT
Sbjct: 421 PKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKT 480
Query: 481 LDGIFSEQVAMGYSHSLVIARDESETEKEKIKKLPEYNPRTL 522
LDGIFSEQVAMGYSHSLVIARDESETEKEKIKKLPEYNPRTL
Sbjct: 481 LDGIFSEQVAMGYSHSLVIARDESETEKEKIKKLPEYNPRTL 522
>gi|29789090 regulator of chromosome condensation 2 [Homo sapiens]
Length = 522
Score = 1070 bits (2767), Expect = 0.0
Identities = 522/522 (100%), Positives = 522/522 (100%)
Query: 1 MPRKKAAAAAWEEPSSGNGTARAGPRKRGGPAGRKRERPERCSSSSGGGSSGDEDGLELD 60
MPRKKAAAAAWEEPSSGNGTARAGPRKRGGPAGRKRERPERCSSSSGGGSSGDEDGLELD
Sbjct: 1 MPRKKAAAAAWEEPSSGNGTARAGPRKRGGPAGRKRERPERCSSSSGGGSSGDEDGLELD 60
Query: 61 GAPGGGKRAARPATAGKAGGAAVVITEPEHTKERVKLEGSKCKGQLLIFGATNWDLIGRK 120
GAPGGGKRAARPATAGKAGGAAVVITEPEHTKERVKLEGSKCKGQLLIFGATNWDLIGRK
Sbjct: 61 GAPGGGKRAARPATAGKAGGAAVVITEPEHTKERVKLEGSKCKGQLLIFGATNWDLIGRK 120
Query: 121 EVPKQQAAYRNLGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKG 180
EVPKQQAAYRNLGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKG
Sbjct: 121 EVPKQQAAYRNLGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKG 180
Query: 181 QLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQT 240
QLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQT
Sbjct: 181 QLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQT 240
Query: 241 DAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQR 300
DAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQR
Sbjct: 241 DAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQR 300
Query: 301 IEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYG 360
IEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYG
Sbjct: 301 IEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYG 360
Query: 361 RLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSRESTMY 420
RLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSRESTMY
Sbjct: 361 RLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSRESTMY 420
Query: 421 PKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKT 480
PKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKT
Sbjct: 421 PKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKT 480
Query: 481 LDGIFSEQVAMGYSHSLVIARDESETEKEKIKKLPEYNPRTL 522
LDGIFSEQVAMGYSHSLVIARDESETEKEKIKKLPEYNPRTL
Sbjct: 481 LDGIFSEQVAMGYSHSLVIARDESETEKEKIKKLPEYNPRTL 522
>gi|126032348 hect domain and RLD 2 [Homo sapiens]
Length = 4834
Score = 130 bits (328), Expect = 2e-30
Identities = 109/409 (26%), Positives = 185/409 (45%), Gaps = 56/409 (13%)
Query: 137 WGPHRYGCLAGVR-VRTVVSGSCAAHSLL--------------ITTEGKLWSWGRNEKGQ 181
WG + G L G+ + V C A + L +T +GKL++ G G+
Sbjct: 3957 WGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGAGGR 4016
Query: 182 LGHGDTKRVEAPRLIEGLSHEVI--VSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQ 239
LG G T+ V P L+E + H I V+ G H LAL+ G V+++GE + G+LG GN+
Sbjct: 4017 LGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNR 4076
Query: 240 TDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQ 299
+ G + +A G S + G+LY++G YG+LGH+
Sbjct: 4077 SPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHS---------- 4126
Query: 300 RIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGAN--HTLVLDSQKRVFSWGFG 357
+ + +L P+ +E + +++ D+ACG+ TL L V+SWG G
Sbjct: 4127 --DSEDQLKPK----LVEALQGHRVV--------DIACGSGDAQTLCLTDDDTVWSWGDG 4172
Query: 358 GYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR-- 415
YG+LG VP +K+ G G ++ G S A+++ G ++ WG + R
Sbjct: 4173 DYGKLGRGGSDGCKVP--MKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLG 4230
Query: 416 ----ESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTI-SWGPSPTFGELGYGDHKPK 470
+ P+ VQ L G ++ ++A G + ++ + +WG + G+L GD
Sbjct: 4231 HGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDE-GQL--GDGTTN 4287
Query: 471 SSTAAQEVKTLDGIFSEQVAMGYSHSLVIARDESETEKEKIKKLP-EYN 518
+ + V L G +VA G +H+L + + + + ++P EYN
Sbjct: 4288 AIQRPRLVAALQGKKVNRVACGSAHTLAWSTSKPASAGKLPAQVPMEYN 4336
Score = 124 bits (310), Expect = 3e-28
Identities = 87/311 (27%), Positives = 148/311 (47%), Gaps = 36/311 (11%)
Query: 139 PHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEG 198
P + L+ V+ V S H+ +T +GK++SWG + G+LGH + PRLIE
Sbjct: 3036 PRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEA 3095
Query: 199 LSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITK 258
L + I ACG +H+ ALT +G ++ +G + G+LG G+ T + + G + +
Sbjct: 3096 LKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQ 3155
Query: 259 MACGAE--FSMIMDCKGNLYSFGCPEYGQLGH-NSDGKFIARAQRIEYDCELVPRRVAIF 315
+ACG+ ++ + +G ++S+G ++G+LG S+G C +P+ +
Sbjct: 3156 VACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEG------------CN-IPQNI--- 3199
Query: 316 IEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRL 375
+ +GQ V + CGA +L L V++WG G Y RLGH P++
Sbjct: 3200 --ERLNGQ-------GVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQV 3250
Query: 376 VKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSRES------TMYPKAVQDLCG 429
V+ G+ + G AV++ G ++ WG + ++ P VQ L G
Sbjct: 3251 VE--GLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEG 3308
Query: 430 WRIRSLACGKS 440
+I +ACG S
Sbjct: 3309 QKITRVACGSS 3319
Score = 123 bits (309), Expect = 4e-28
Identities = 100/348 (28%), Positives = 156/348 (44%), Gaps = 45/348 (12%)
Query: 166 TTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFA 225
T K++ WG N+K QLG +++ P E LS +V A G A+T G V+A
Sbjct: 2956 TIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYA 3015
Query: 226 FGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMAC---GAEFSMIMDCKGNLYSFGCPE 282
GE G+LGLG + VP P QI + K G + + G ++S+G +
Sbjct: 3016 CGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGD 3075
Query: 283 YGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHT 342
G+LGH S +C+ PR + KTK +RD+ACG++H+
Sbjct: 3076 DGKLGHFS-----------RMNCD-KPRLIEAL--KTKR----------IRDIACGSSHS 3111
Query: 343 LVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGY--TCSFAVS 400
L S +++WG G YGRLGH + ++ P++VK+ G Q+ G + A++
Sbjct: 3112 AALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKV--LLGHRVIQVACGSRDAQTLALT 3169
Query: 401 EVGGLFFWGATNTSR------ESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTI-SW 453
+ G +F WG + + E P+ ++ L G + + CG + + +W
Sbjct: 3170 DEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTW 3229
Query: 454 GPSPTFGELGYGD--HKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVI 499
G F LG+G H K Q V+ L G VA+G H L +
Sbjct: 3230 GKGDYF-RLGHGSDVHVRK----PQVVEGLRGKKIVHVAVGALHCLAV 3272
Score = 117 bits (293), Expect = 3e-26
Identities = 106/369 (28%), Positives = 167/369 (45%), Gaps = 51/369 (13%)
Query: 145 LAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHG-DTKRVEAPRLIEGLSHEV 203
L+ + V V GS + + +T EGK+++ G G+LG G + V PR I LS V
Sbjct: 2989 LSALNVVQVAGGSKSLFA--VTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYV 3046
Query: 204 I--VSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMAC 261
+ V+ G H ALT G VF++GE G+LG ++ + + I +AC
Sbjct: 3047 VKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIAC 3106
Query: 262 GAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKD 321
G+ S + G LY++G EYG+LGH + +L P+ V + +
Sbjct: 3107 GSSHSAALTSSGELYTWGLGEYGRLGHGDN------------TTQLKPKMVKVLLGHR-- 3152
Query: 322 GQILPVPNVVVRDVACGAN--HTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLF 379
V VACG+ TL L + VFSWG G +G+LG + +P+ ++
Sbjct: 3153 ----------VIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERL 3202
Query: 380 DFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR------ESTMYPKAVQDLCGWRIR 433
+ G+G QI G S A+++ G ++ WG + R P+ V+ L G +I
Sbjct: 3203 N--GQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIV 3260
Query: 434 SLACGKSSIIVAADESTI-SWGPSPTFGELGYG----DHKPKSSTAAQEVKTLDGIFSEQ 488
+A G + D + +WG + G+ G G + KP V+ L+G +
Sbjct: 3261 HVAVGALHCLAVTDSGQVYAWGDN-DHGQQGNGTTTVNRKPTL------VQGLEGQKITR 3313
Query: 489 VAMGYSHSL 497
VA G SHS+
Sbjct: 3314 VACGSSHSV 3322
Score = 116 bits (291), Expect = 4e-26
Identities = 98/370 (26%), Positives = 172/370 (46%), Gaps = 54/370 (14%)
Query: 139 PHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEG 198
P L R+R + GS +HS +T+ G+L++WG E G+LGHGD P++++
Sbjct: 3090 PRLIEALKTKRIRDIACGS--SHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKV 3147
Query: 199 LSHEVIVSAACGRN--HTLALTETGSVFAFGENKMGQLGLGNQTDA-VPSPAQIMYNGQP 255
L ++ ACG TLALT+ G VF++G+ G+LG G +P + + NGQ
Sbjct: 3148 LLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERL-NGQG 3206
Query: 256 ITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIF 315
+ ++ CGA+FS+ + G ++++G +Y +LGH SD +
Sbjct: 3207 VCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSD----------------------VH 3244
Query: 316 IEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRL 375
+ K + + L +V VA GA H L + +V++WG +G+ G+ P L
Sbjct: 3245 VRKPQVVEGLRGKKIV--HVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTL 3302
Query: 376 VKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSRESTMYPKAVQDLCGWRIRSL 435
V+ G+ +++ G + S A + V AT + E ++ A L
Sbjct: 3303 VQ--GLEGQKITRVACGSSHSVAWTTVD-----VATPSVHEPVLFQTARDPL-------- 3347
Query: 436 ACGKSSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGY-- 493
G S + V +D + + + G + KP + A+ + +LDG ++Q A+ +
Sbjct: 3348 --GASYLGVPSDADSSAASNKIS----GASNSKPNRPSLAKILLSLDGNLAKQQALSHIL 3401
Query: 494 -SHSLVIARD 502
+ ++ ARD
Sbjct: 3402 TALQIMYARD 3411
Score = 114 bits (285), Expect = 2e-25
Identities = 85/307 (27%), Positives = 143/307 (46%), Gaps = 40/307 (13%)
Query: 145 LAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEV- 203
LA + + + S H L + G+++SWG + G+LGHGDT +E P++I S +
Sbjct: 490 LASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQA 549
Query: 204 ---IVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMA 260
+V ACG ++ A+T G ++ +G G+LG G+ D G + +A
Sbjct: 550 GKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVA 609
Query: 261 CGA--EFSMIMDCKGNLYSFGCPEYGQLGH-NSDGKFIARAQRIEYDCELVPRRVAIFIE 317
CG+ ++ + G ++S+G +YG+LG SDG C+ P+ IE
Sbjct: 610 CGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDG------------CK-TPK----LIE 652
Query: 318 KTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVK 377
K +D ++ V CG+ ++ L +V+SWG G RLGH ++ P+L++
Sbjct: 653 KLQDLDVV--------KVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLE 704
Query: 378 LFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGAT------NTSRESTMYPKAVQDLCGWR 431
G+ + AG T A++E + WG+ +T R + P A+ L
Sbjct: 705 --GLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPAALPGLDTKH 762
Query: 432 IRSLACG 438
I +ACG
Sbjct: 763 IVGIACG 769
Score = 102 bits (253), Expect = 1e-21
Identities = 69/216 (31%), Positives = 105/216 (48%), Gaps = 30/216 (13%)
Query: 143 GCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHE 202
G AG V + GS +S IT EG+L++WGR G+LGHG ++ P L+ GL
Sbjct: 546 GKQAGKHVVHIACGS--TYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGL 603
Query: 203 VIVSAACGRN--HTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQI-MYNGQPITKM 259
++ ACG TLA+TE G V+++G+ G+LG G +D +P I + K+
Sbjct: 604 KVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGG-SDGCKTPKLIEKLQDLDVVKV 662
Query: 260 ACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKT 319
CG++FS+ + G +YS+G + +LGH ++ + + Y K
Sbjct: 663 RCGSQFSIALTKDGQVYSWGKGDNQRLGHGTE-------EHVRY-------------PKL 702
Query: 320 KDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWG 355
+G + V DVA G+ H L L V SWG
Sbjct: 703 LEG----LQGKKVIDVAAGSTHCLALTEDSEVHSWG 734
Score = 85.9 bits (211), Expect = 8e-17
Identities = 84/343 (24%), Positives = 140/343 (40%), Gaps = 64/343 (18%)
Query: 180 GQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQ 239
G +G V P EGL++ + AC L L+ G V+ N
Sbjct: 429 GLIGWKYYANVIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYN---------- 478
Query: 240 TDAVPSPAQIMYNGQPITKMACGAE--FSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIAR 297
+D + + I K+A ++ + + G +YS+GC + G+LGH G +
Sbjct: 479 SDTLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGH---GDTVPL 535
Query: 298 AQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFG 357
+ P+ ++ F K ++ +ACG+ ++ + ++ +++WG G
Sbjct: 536 EE---------PKVISAFSGKQAGKHVV--------HIACGSTYSAAITAEGELYTWGRG 578
Query: 358 GYGRLGHAEQKDEMVPRLV------KLFDFP-GRGASQIYAGYTCSFAVSEVGGLFFWGA 410
YGRLGH +DE +P LV K+ D G G +Q + AV+E G ++ WG
Sbjct: 579 NYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQ-------TLAVTENGQVWSWGD 631
Query: 411 TNTSR------ESTMYPKAVQDLCGWRIRSLACGKS-SIIVAADESTISWGPSPTFGELG 463
+ + + PK ++ L + + CG SI + D SWG LG
Sbjct: 632 GDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDN-QRLG 690
Query: 464 YGDHK----PKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARD 502
+G + PK Q K +D VA G +H L + D
Sbjct: 691 HGTEEHVRYPKLLEGLQGKKVID------VAAGSTHCLALTED 727
Score = 82.4 bits (202), Expect = 9e-16
Identities = 75/298 (25%), Positives = 127/298 (42%), Gaps = 38/298 (12%)
Query: 214 TLALTETGSVFAFGENKMGQL-GLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCK 272
TL+ +G+++ +G N GQL G+ VP+P + + +P+ ++ G + +
Sbjct: 3945 TLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPV-QLIGGEQTLFAVTAD 4003
Query: 273 GNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVV 332
G LY+ G G+LG I + + L+ +FI+K
Sbjct: 4004 GKLYATGYGAGGRLG-------IGGTESVSTP-TLLESIQHVFIKKVA------------ 4043
Query: 333 RDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAG 392
V G H L L S+ V+SWG G+LGH + PR+++ G + AG
Sbjct: 4044 --VNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIE--SLRGIEVVDVAAG 4099
Query: 393 YTCSFAVSEVGGLFFWGATNTSR------ESTMYPKAVQDLCGWRIRSLACGK---SSII 443
S V+ G L+ WG R E + PK V+ L G R+ +ACG ++
Sbjct: 4100 GAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLC 4159
Query: 444 VAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIAR 501
+ D++ SWG +G+LG G ++ +L G+ +V G S+ + +
Sbjct: 4160 LTDDDTVWSWGDG-DYGKLGRGG--SDGCKVPMKIDSLTGLGVVKVECGSQFSVALTK 4214
>gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]
Length = 4861
Score = 130 bits (327), Expect = 3e-30
Identities = 88/276 (31%), Positives = 131/276 (47%), Gaps = 35/276 (12%)
Query: 148 VRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSA 207
V + V S HS+ +T G+++SWG + G+LGHG++ R PR IE L E +V
Sbjct: 4080 VVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQM 4139
Query: 208 ACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSM 267
+CG H+ +T G +F FG G+LGLGN ++ G I ++ACG ++
Sbjct: 4140 SCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTL 4199
Query: 268 IMDCKGNL-YSFGCPEYGQLG-HNSDGKFIARAQRIEYDCELVPRRVA----IFIEKTKD 321
+ G++ ++FG +YG+LG NS K + Q+I+ C + ++VA + TKD
Sbjct: 4200 AVSADGSMVWAFGDGDYGKLGLGNSTAK--SSPQKIDVLCGIGIKKVACGTQFSVALTKD 4257
Query: 322 G-------------------------QILPVPNVVVRDVACGANHTLVLDSQKRVFSWGF 356
G QI + V++ DVA GA HTL L S V++WG
Sbjct: 4258 GHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGS 4317
Query: 357 GGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAG 392
G+LG P LV G+ QI AG
Sbjct: 4318 NSEGQLGLGHTNHVREPTLVT--GLQGKNVRQISAG 4351
Score = 125 bits (314), Expect = 9e-29
Identities = 94/347 (27%), Positives = 165/347 (47%), Gaps = 41/347 (11%)
Query: 162 SLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVI--VSAACGRN-HTLALT 218
+ +I+T+G + + G+ G+LG GD+ + + H I VS++ G + HTLA T
Sbjct: 415 TFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFT 474
Query: 219 ETGSVFAFGENKMGQLGLGNQ-TDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYS 277
G VF++G+ G+LG GN T P Q G+ + ++ G S + G LY+
Sbjct: 475 TEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYT 534
Query: 278 FGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVAC 337
+G ++G+LGH R + ++ + V +V+C
Sbjct: 535 WGEGDFGRLGHGDSNS----------------RNIPTLVKDISN----------VGEVSC 568
Query: 338 GANHTLVLDSQKR-VFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCS 396
G++HT+ L R V+S+G G G+LGH + P++++ G ++ AG S
Sbjct: 569 GSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQ--GMFIRKVCAGSQSS 626
Query: 397 FAVSEVGGLFFWGA-----TNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAA-DEST 450
A++ G ++ WG +S + + PK +++L RI ++ G S + + D
Sbjct: 627 LALTSTGQVYAWGCGACLGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEV 686
Query: 451 ISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSL 497
+WG + + G+ G G+ T ++V LDGI +Q++ G SHSL
Sbjct: 687 YAWGNN-SMGQCGQGN-STGPITKPKKVSGLDGIAIQQISAGTSHSL 731
Score = 112 bits (279), Expect = 1e-24
Identities = 107/392 (27%), Positives = 181/392 (46%), Gaps = 68/392 (17%)
Query: 136 LWGPHRYGCLAGVRVRTVVSGSCAAHS------------LLITTEGKLWSWGRNEKGQLG 183
LWG R+G LA +V + + S +I G + + G G+LG
Sbjct: 4001 LWGAGRHGQLAEAGRNVMVPAAAPSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLG 4060
Query: 184 HGDTKRVEAPRLIEGLSHEVIVS--AACGRN-HTLALTETGSVFAFGENKMGQLGLGNQT 240
G++ + +I L V+ +CG + H++ALTE+G VF++G+ G+LG GN +
Sbjct: 4061 QGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGN-S 4119
Query: 241 DAVPSPAQI-MYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQ 299
D P QI G+ + +M+CG + S ++ G L++FG +YG+LG +
Sbjct: 4120 DRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSN------ 4173
Query: 300 RIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQ-KRVFSWGFGG 358
+ +P RV +E + GQ VACG NHTL + + V+++G G
Sbjct: 4174 ------KKLPERVTA-LEGYQIGQ-----------VACGLNHTLAVSADGSMVWAFGDGD 4215
Query: 359 YGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWG--------- 409
YG+LG + P+ K+ G G ++ G S A+++ G ++ +G
Sbjct: 4216 YGKLGLGNSTAKSSPQ--KIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPE 4273
Query: 410 --ATNTSRESTMYPKAVQDLCGWRIRSLACG-KSSIIVAADESTISWGPSPTFGELGYG- 465
A N +R P+ + L G I +A G + ++ +A++ +WG S + G+LG G
Sbjct: 4274 GRARNHNR-----PQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWG-SNSEGQLGLGH 4327
Query: 466 -DHKPKSSTAAQEVKTLDGIFSEQVAMGYSHS 496
+H + + V L G Q++ G HS
Sbjct: 4328 TNHVREPTL----VTGLQGKNVRQISAGRCHS 4355
Score = 111 bits (277), Expect = 2e-24
Identities = 95/346 (27%), Positives = 155/346 (44%), Gaps = 53/346 (15%)
Query: 171 LWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENK 230
++ WG GQL + V P S V CG+N T + G+V A GE
Sbjct: 3999 VYLWGAGRHGQLAEAG-RNVMVPAAAPSFSQAQQV--ICGQNCTFVIQANGTVLACGEGS 4055
Query: 231 MGQLGLGNQTDAVPSPAQIMYNGQPITKM--ACGAE-FSMIMDCKGNLYSFGCPEYGQLG 287
G+LG GN D G +T++ +CG++ SM + G ++S+G +YG+LG
Sbjct: 4056 YGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLG 4115
Query: 288 H-NSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLD 346
H NSD R +R PR QI + V ++CG H+ V+
Sbjct: 4116 HGNSD-----RQRR--------PR------------QIEALQGEEVVQMSCGFKHSAVVT 4150
Query: 347 SQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLF 406
S ++F++G G YGRLG ++ +P V + G Q+ G + AVS G +
Sbjct: 4151 SDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALE--GYQIGQVACGLNHTLAVSADGSMV 4208
Query: 407 F---------WGATNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSP 457
+ G N++ +S+ P+ + LCG I+ +ACG + + +
Sbjct: 4209 WAFGDGDYGKLGLGNSTAKSS--PQKIDVLCGIGIKKVACGTQFSVALTKDGHVY----- 4261
Query: 458 TFGE---LGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIA 500
TFG+ +G + + ++ Q++ L G+ E VA+G H+L +A
Sbjct: 4262 TFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALA 4307
Score = 103 bits (258), Expect = 3e-22
Identities = 78/307 (25%), Positives = 143/307 (46%), Gaps = 44/307 (14%)
Query: 161 HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEG-LSHEVIVSAACGRNHTLALTE 219
H+L TTEG+++SWG + G+LGHG++ + P+LI+G L +V+V + G H+ A+TE
Sbjct: 469 HTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTE 528
Query: 220 TGSVFAFGENKMGQLGLGNQTDA-VPSPAQIMYNGQPITKMACGAEFSMIMDCKG-NLYS 277
G ++ +GE G+LG G+ +P+ + + N + +++CG+ ++ + G ++S
Sbjct: 529 DGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISN---VGEVSCGSSHTIALSKDGRTVWS 585
Query: 278 FGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVAC 337
FG + G+LGH + Y +++ +FI K V
Sbjct: 586 FGGGDNGKLGHGDTNRV--------YKPKVIEALQGMFIRK----------------VCA 621
Query: 338 GANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSF 397
G+ +L L S +V++WG G G +E + P+L++ + + G +
Sbjct: 622 GSQSSLALTSTGQVYAWGCGACLGCGSSE-ATALRPKLIE--ELAATRIVDVSIGDSHCL 678
Query: 398 AVSEVGGLFFWG-------ATNTSRESTMYPKAVQDLCGWRIRSLACGKSSII----VAA 446
A+S ++ WG S PK V L G I+ ++ G S + +
Sbjct: 679 ALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLAWTALPR 738
Query: 447 DESTISW 453
D ++W
Sbjct: 739 DRQVVAW 745
Score = 91.3 bits (225), Expect = 2e-18
Identities = 84/312 (26%), Positives = 134/312 (42%), Gaps = 43/312 (13%)
Query: 202 EVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMAC 261
E I+S A R L V+ +G + GQL + VP+ A Q ++ C
Sbjct: 3978 EQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMVPAAAPSFSQAQ---QVIC 4034
Query: 262 GAEFSMIMDCKGNLYSFGCPEYGQLGH-NSDGKFIARAQRIEYDCELVPRRVAIFIEKTK 320
G + ++ G + + G YG+LG NSD +
Sbjct: 4035 GQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTV---------------------- 4072
Query: 321 DGQILPVPNVVVRDV--ACGAN-HTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVK 377
I + VV + +CG++ H++ L VFSWG G YG+LGH + PR ++
Sbjct: 4073 ---ISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIE 4129
Query: 378 LFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR------ESTMYPKAVQDLCGWR 431
G Q+ G+ S V+ G LF +G + R + P+ V L G++
Sbjct: 4130 ALQ--GEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQ 4187
Query: 432 IRSLACG-KSSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVA 490
I +ACG ++ V+AD S + +G+LG G+ KSS Q++ L GI ++VA
Sbjct: 4188 IGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSS--PQKIDVLCGIGIKKVA 4245
Query: 491 MGYSHSLVIARD 502
G S+ + +D
Sbjct: 4246 CGTQFSVALTKD 4257
Score = 71.6 bits (174), Expect = 2e-12
Identities = 54/205 (26%), Positives = 92/205 (44%), Gaps = 33/205 (16%)
Query: 157 SC-AAHSLLITTEGK-LWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHT 214
SC ++H++ ++ +G+ +WS+G + G+LGHGDT RV P++IE L I G +
Sbjct: 567 SCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSS 626
Query: 215 LALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQI-MYNGQPITKMACGAEFSMIMDCKG 273
LALT TG V+A+G LG G+ P I I ++ G + +
Sbjct: 627 LALTSTGQVYAWGCGAC--LGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDN 684
Query: 274 NLYSFGCPEYGQLGH-NSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVV 332
+Y++G GQ G NS G TK ++ + + +
Sbjct: 685 EVYAWGNNSMGQCGQGNSTGPI------------------------TKPKKVSGLDGIAI 720
Query: 333 RDVACGANHTL---VLDSQKRVFSW 354
+ ++ G +H+L L ++V +W
Sbjct: 721 QQISAGTSHSLAWTALPRDRQVVAW 745
Score = 65.9 bits (159), Expect = 9e-11
Identities = 51/182 (28%), Positives = 84/182 (46%), Gaps = 15/182 (8%)
Query: 333 RDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAG 392
+ V CG N T V+ + V + G G YGRLG D V ++ G +Q+
Sbjct: 4030 QQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQ--GFVVTQLVTS 4087
Query: 393 YTC---SFAVSEVGGLFFWGATNTSR------ESTMYPKAVQDLCGWRIRSLACG-KSSI 442
S A++E G +F WG + + + P+ ++ L G + ++CG K S
Sbjct: 4088 CGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSA 4147
Query: 443 IVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARD 502
+V +D ++G + +G LG G+ K + V L+G QVA G +H+L ++ D
Sbjct: 4148 VVTSDGKLFTFG-NGDYGRLGLGNTSNKK--LPERVTALEGYQIGQVACGLNHTLAVSAD 4204
Query: 503 ES 504
S
Sbjct: 4205 GS 4206
Score = 57.8 bits (138), Expect = 2e-08
Identities = 30/80 (37%), Positives = 44/80 (55%), Gaps = 2/80 (2%)
Query: 139 PHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEG 198
P + LAGV + V G A H+L + + G +++WG N +GQLG G T V P L+ G
Sbjct: 4282 PQQIPVLAGVIIEDVAVG--AEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTG 4339
Query: 199 LSHEVIVSAACGRNHTLALT 218
L + + + GR H+ A T
Sbjct: 4340 LQGKNVRQISAGRCHSAAWT 4359
Score = 51.2 bits (121), Expect = 2e-06
Identities = 48/181 (26%), Positives = 82/181 (45%), Gaps = 22/181 (12%)
Query: 335 VACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYA--- 391
+ G T V+ + V + G G YGRLG + ++ L KL P R ++ +
Sbjct: 408 IEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQST--LKKLTFEPHRSIKKVSSSKG 465
Query: 392 --GYTCSFAVSEVGGLFFWGATNTSR------ESTMYPKAVQ-DLCGWRIRSLACG-KSS 441
G+T +F G +F WG + + + YPK +Q L G + ++ G + S
Sbjct: 466 SDGHTLAFTTE--GEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHS 523
Query: 442 IIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIAR 501
V D +WG FG LG+GD ++ VK + + +V+ G SH++ +++
Sbjct: 524 AAVTEDGELYTWGEG-DFGRLGHGDSNSRNIPTL--VKDISNV--GEVSCGSSHTIALSK 578
Query: 502 D 502
D
Sbjct: 579 D 579
>gi|7657152 hect domain and RLD 3 [Homo sapiens]
Length = 1050
Score = 124 bits (312), Expect = 2e-28
Identities = 85/271 (31%), Positives = 129/271 (47%), Gaps = 30/271 (11%)
Query: 139 PHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTK-RVEAPRLIE 197
P + G LA + V G +HSL ++ G+L+SWG GQLG T+ V PRLI+
Sbjct: 75 PEQIGALADQHIIHVACGE--SHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQ 132
Query: 198 GLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQI-MYNGQPI 256
L+ + I+ +CG H LAL G F +G+N GQLGLG + + SP ++ G P+
Sbjct: 133 KLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPL 192
Query: 257 TKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFI 316
++A G S + G ++ +G GQLG ++ + E C +
Sbjct: 193 AQVAAGGAHSFALSLSGAVFGWGMNNAGQLG-------LSDEKDRESPCHV--------- 236
Query: 317 EKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLV 376
++L VV ++CG HT VL VF++G G G+LGH DE+ PR
Sbjct: 237 ------KLLRTQKVVY--ISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPR-- 286
Query: 377 KLFDFPGRGASQIYAGYTCSFAVSEVGGLFF 407
++ + G +QI G + A GL +
Sbjct: 287 RVLELMGSEVTQIACGRQHTLAFVPSSGLIY 317
Score = 123 bits (309), Expect = 4e-28
Identities = 100/356 (28%), Positives = 161/356 (45%), Gaps = 50/356 (14%)
Query: 129 YRNLGQ-----NLWG----PHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEK 179
Y +LGQ NL G P G ++ V+ V G HS+ + +G++++ G N K
Sbjct: 6 YWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGG--NHSVFLLEDGEVYTCGLNTK 63
Query: 180 GQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQ 239
GQLGH + P I L+ + I+ ACG +H+LAL++ G +F++G GQLGL
Sbjct: 64 GQLGH--EREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTT 121
Query: 240 TDAVPSPAQIM-YNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARA 298
D+V P I N Q I +++CG + + G +++G +GQLG
Sbjct: 122 EDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGK-------- 173
Query: 299 QRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGG 358
E+ + P+RV + + + VA G H+ L VF WG
Sbjct: 174 ---EFPSQASPQRVR------------SLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNN 218
Query: 359 YGRLGHAEQKDEMVPRLVKLFDFPGRGASQIY--AGYTCSFAVSEVGGLFFWGA------ 410
G+LG +++KD P VKL R +Y G + +++ GG+F +GA
Sbjct: 219 AGQLGLSDEKDRESPCHVKLL----RTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQL 274
Query: 411 TNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTISWG-PSPTFGELGYG 465
+ S + P+ V +L G + +ACG+ + S + + G+LG G
Sbjct: 275 GHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTG 330
Score = 102 bits (255), Expect = 7e-22
Identities = 62/186 (33%), Positives = 92/186 (49%), Gaps = 15/186 (8%)
Query: 104 GQLLIFGATNWDLIGR-KEVPKQQAAYRNLGQNLWGPHRYGCLAGVRVRTVVSGSCAAHS 162
GQ +G + +G KE P Q + P R L G+ + V +G AHS
Sbjct: 156 GQFFTWGKNSHGQLGLGKEFPSQAS-----------PQRVRSLEGIPLAQVAAGG--AHS 202
Query: 163 LLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGS 222
++ G ++ WG N GQLG D K E+P ++ L + +V +CG HT LT++G
Sbjct: 203 FALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGG 262
Query: 223 VFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSM-IMDCKGNLYSFGCP 281
VF FG GQLG + D V + G +T++ACG + ++ + G +Y+FGC
Sbjct: 263 VFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCG 322
Query: 282 EYGQLG 287
GQLG
Sbjct: 323 ARGQLG 328
Score = 81.3 bits (199), Expect = 2e-15
Identities = 57/179 (31%), Positives = 91/179 (50%), Gaps = 18/179 (10%)
Query: 332 VRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQ--KDEMVPRLVKLFDFPGRGASQI 389
V++VACG NH++ L V++ G G+LGH + K E + L + +
Sbjct: 36 VKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQIGALAD------QHIIHV 89
Query: 390 YAGYTCSFAVSEVGGLFFWGATN-------TSRESTMYPKAVQDLCGWRIRSLACGK-SS 441
G + S A+S+ G LF WGA + T+ +S P+ +Q L I ++CG
Sbjct: 90 ACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHC 149
Query: 442 IIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIA 500
+ +AAD +WG + + G+LG G P S + Q V++L+GI QVA G +HS ++
Sbjct: 150 LALAADGQFFTWGKN-SHGQLGLGKEFP-SQASPQRVRSLEGIPLAQVAAGGAHSFALS 206
Score = 61.2 bits (147), Expect = 2e-09
Identities = 37/104 (35%), Positives = 54/104 (51%), Gaps = 3/104 (2%)
Query: 148 VRVRTVVSGSCAA-HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVS 206
+R + VV SC H+ ++T G ++++G GQLGH PR + L +
Sbjct: 239 LRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQ 298
Query: 207 AACGRNHTLALT-ETGSVFAFGENKMGQLGLGNQTDA-VPSPAQ 248
ACGR HTLA +G ++AFG GQLG G+ + PSP +
Sbjct: 299 IACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVK 342
>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
Length = 1049
Score = 120 bits (300), Expect = 4e-27
Identities = 95/343 (27%), Positives = 157/343 (45%), Gaps = 39/343 (11%)
Query: 139 PHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEG 198
P + RVR V G H++ + +G +++ G N+ GQLGH +++ P +
Sbjct: 25 PRKSDFFINKRVRDVGCG--LRHTVFVLDDGTVYTCGCNDLGQLGHEKSRK--KPEQVVA 80
Query: 199 LSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQI-MYNGQPIT 257
L + IV+ +CG HTLAL + G V+A+G + GQLGL + + P I + I
Sbjct: 81 LDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIV 140
Query: 258 KMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIE 317
++ACG S+ + ++ +G +YGQLG +D K Q ++
Sbjct: 141 QVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLK--------------- 185
Query: 318 KTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVK 377
+L +P VA G H+ VL +F WG +G+LG ++ D VP L+K
Sbjct: 186 -----SLLGIP---FMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLK 237
Query: 378 LFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGA------TNTSRESTMYPKAVQDLCGWR 431
+ I G + A+++ GG+F +GA + S + P+ V +L G
Sbjct: 238 --SLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSI 295
Query: 432 IRSLACGK--SSIIVAADESTISWGPSPTFGELGYGDHKPKSS 472
+ +ACG+ +S V + S+G G+LG G + S
Sbjct: 296 VTEIACGRQHTSAFVPSSGRIYSFGLGGN-GQLGTGSTSNRKS 337
Score = 118 bits (295), Expect = 1e-26
Identities = 83/272 (30%), Positives = 135/272 (49%), Gaps = 42/272 (15%)
Query: 151 RTVVSGSCA-AHSLLITTEGKLWSWGRNEKGQLGH-GDTKRVEAPRLIEGLSHEVIVSAA 208
+ +V+ SC AH+L + +G++++WG + GQLG G + + PR I+ LS IV A
Sbjct: 84 QNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVA 143
Query: 209 CGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYN--GQPITKMACGAEFS 266
CG H+LAL++ VF +G+NK GQLGLG SP Q++ + G P ++A G S
Sbjct: 144 CGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSP-QLLKSLLGIPFMQVAAGGAHS 202
Query: 267 MIMDCKGNLYSFGCPEYGQLGHNSDG-KFIA------RAQRIEYDCELVPRRVAIFIEKT 319
++ G ++ +G ++GQLG N + +++ R+Q+I Y C A+ T
Sbjct: 203 FVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAAL----T 258
Query: 320 KDG-------------------------QILPVPNVVVRDVACGANHTLV-LDSQKRVFS 353
K+G ++ + +V ++ACG HT + S R++S
Sbjct: 259 KEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYS 318
Query: 354 WGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRG 385
+G GG G+LG + P VK +P G
Sbjct: 319 FGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNG 350
Score = 105 bits (262), Expect = 1e-22
Identities = 95/336 (28%), Positives = 147/336 (43%), Gaps = 46/336 (13%)
Query: 174 WGRNEKGQLGHG--DTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKM 231
WG GQLG G D + V PR + ++ + CG HT+ + + G+V+ G N +
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 232 GQLGLGNQTDAVPSPAQIM-YNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNS 290
GQLG + P Q++ + Q I ++CG ++ ++ KG +Y++G GQLG
Sbjct: 64 GQLG---HEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVG 120
Query: 291 DGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKR 350
+C VPR I+ D QI+ VACG H+L L
Sbjct: 121 -----------SEECIRVPRN----IKSLSDIQIV--------QVACGYYHSLALSKASE 157
Query: 351 VFSWGFGGYGRLG-HAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWG 409
VF WG YG+LG + K + P+L+K G Q+ AG SF ++ G +F WG
Sbjct: 158 VFCWGQNKYGQLGLGTDCKKQTSPQLLK--SLLGIPFMQVAAGGAHSFVLTLSGAIFGWG 215
Query: 410 ATNTSR-----ESTMY-PKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGELG 463
+ E+ Y P ++ L +I + CG+ E + TFG G
Sbjct: 216 RNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVF-----TFGAGG 270
Query: 464 YGDHKPKSST---AAQEVKTLDGIFSEQVAMGYSHS 496
YG S++ ++V L G ++A G H+
Sbjct: 271 YGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHT 306
Score = 98.2 bits (243), Expect = 2e-20
Identities = 62/196 (31%), Positives = 89/196 (45%), Gaps = 25/196 (12%)
Query: 137 WGPHRYG------------------CLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNE 178
WG ++YG L G+ V +G AHS ++T G ++ WGRN+
Sbjct: 161 WGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGG--AHSFVLTLSGAIFGWGRNK 218
Query: 179 KGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGN 238
GQLG D P L++ L + IV CG +HT ALT+ G VF FG GQLG +
Sbjct: 219 FGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNS 278
Query: 239 QTDAVPSPAQIMYNGQPITKMACGAEF-SMIMDCKGNLYSFGCPEYGQLG----HNSDGK 293
+ + G +T++ACG + S + G +YSFG GQLG N
Sbjct: 279 TSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSP 338
Query: 294 FIARAQRIEYDCELVP 309
F + Y+ + +P
Sbjct: 339 FTVKGNWYPYNGQCLP 354
Score = 71.6 bits (174), Expect = 2e-12
Identities = 64/230 (27%), Positives = 100/230 (43%), Gaps = 36/230 (15%)
Query: 278 FGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVAC 337
+G +GQLG I+ + L PR+ FI K VRDV C
Sbjct: 4 WGNASFGQLGLGG----------IDEEIVLEPRKSDFFINKR------------VRDVGC 41
Query: 338 GANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSF 397
G HT+ + V++ G G+LGH +K P V D + + G +
Sbjct: 42 GLRHTVFVLDDGTVYTCGCNDLGQLGH--EKSRKKPEQVVALD--AQNIVAVSCGEAHTL 97
Query: 398 AVSEVGGLFFWGATNT-------SRESTMYPKAVQDLCGWRIRSLACGK-SSIIVAADES 449
A+++ G ++ WG + S E P+ ++ L +I +ACG S+ ++
Sbjct: 98 ALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASE 157
Query: 450 TISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVI 499
WG + +G+LG G K T+ Q +K+L GI QVA G +HS V+
Sbjct: 158 VFCWGQNK-YGQLGLGTDC-KKQTSPQLLKSLLGIPFMQVAAGGAHSFVL 205
Score = 42.0 bits (97), Expect = 0.001
Identities = 37/153 (24%), Positives = 69/153 (45%), Gaps = 7/153 (4%)
Query: 354 WGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNT 413
WG +G+LG +E+V K F + + G + V + G ++ G +
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 414 SR----ESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTI-SWGPSPTFGELGYGDHK 468
+ +S P+ V L I +++CG++ + D+ + +WG G+LG +
Sbjct: 64 GQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSD-GQLGLVGSE 122
Query: 469 PKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIAR 501
+ + +K+L I QVA GY HSL +++
Sbjct: 123 -ECIRVPRNIKSLSDIQIVQVACGYYHSLALSK 154
>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
Length = 1057
Score = 120 bits (300), Expect = 4e-27
Identities = 95/343 (27%), Positives = 157/343 (45%), Gaps = 39/343 (11%)
Query: 139 PHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEG 198
P + RVR V G H++ + +G +++ G N+ GQLGH +++ P +
Sbjct: 25 PRKSDFFINKRVRDVGCG--LRHTVFVLDDGTVYTCGCNDLGQLGHEKSRK--KPEQVVA 80
Query: 199 LSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQI-MYNGQPIT 257
L + IV+ +CG HTLAL + G V+A+G + GQLGL + + P I + I
Sbjct: 81 LDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIV 140
Query: 258 KMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIE 317
++ACG S+ + ++ +G +YGQLG +D K Q ++
Sbjct: 141 QVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLK--------------- 185
Query: 318 KTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVK 377
+L +P VA G H+ VL +F WG +G+LG ++ D VP L+K
Sbjct: 186 -----SLLGIP---FMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLK 237
Query: 378 LFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGA------TNTSRESTMYPKAVQDLCGWR 431
+ I G + A+++ GG+F +GA + S + P+ V +L G
Sbjct: 238 --SLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSI 295
Query: 432 IRSLACGK--SSIIVAADESTISWGPSPTFGELGYGDHKPKSS 472
+ +ACG+ +S V + S+G G+LG G + S
Sbjct: 296 VTEIACGRQHTSAFVPSSGRIYSFGLGGN-GQLGTGSTSNRKS 337
Score = 118 bits (295), Expect = 1e-26
Identities = 83/272 (30%), Positives = 135/272 (49%), Gaps = 42/272 (15%)
Query: 151 RTVVSGSCA-AHSLLITTEGKLWSWGRNEKGQLGH-GDTKRVEAPRLIEGLSHEVIVSAA 208
+ +V+ SC AH+L + +G++++WG + GQLG G + + PR I+ LS IV A
Sbjct: 84 QNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVA 143
Query: 209 CGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYN--GQPITKMACGAEFS 266
CG H+LAL++ VF +G+NK GQLGLG SP Q++ + G P ++A G S
Sbjct: 144 CGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSP-QLLKSLLGIPFMQVAAGGAHS 202
Query: 267 MIMDCKGNLYSFGCPEYGQLGHNSDG-KFIA------RAQRIEYDCELVPRRVAIFIEKT 319
++ G ++ +G ++GQLG N + +++ R+Q+I Y C A+ T
Sbjct: 203 FVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAAL----T 258
Query: 320 KDG-------------------------QILPVPNVVVRDVACGANHTLV-LDSQKRVFS 353
K+G ++ + +V ++ACG HT + S R++S
Sbjct: 259 KEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYS 318
Query: 354 WGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRG 385
+G GG G+LG + P VK +P G
Sbjct: 319 FGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNG 350
Score = 105 bits (262), Expect = 1e-22
Identities = 95/336 (28%), Positives = 147/336 (43%), Gaps = 46/336 (13%)
Query: 174 WGRNEKGQLGHG--DTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKM 231
WG GQLG G D + V PR + ++ + CG HT+ + + G+V+ G N +
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 232 GQLGLGNQTDAVPSPAQIM-YNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNS 290
GQLG + P Q++ + Q I ++CG ++ ++ KG +Y++G GQLG
Sbjct: 64 GQLG---HEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVG 120
Query: 291 DGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKR 350
+C VPR I+ D QI+ VACG H+L L
Sbjct: 121 -----------SEECIRVPRN----IKSLSDIQIV--------QVACGYYHSLALSKASE 157
Query: 351 VFSWGFGGYGRLG-HAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWG 409
VF WG YG+LG + K + P+L+K G Q+ AG SF ++ G +F WG
Sbjct: 158 VFCWGQNKYGQLGLGTDCKKQTSPQLLK--SLLGIPFMQVAAGGAHSFVLTLSGAIFGWG 215
Query: 410 ATNTSR-----ESTMY-PKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGELG 463
+ E+ Y P ++ L +I + CG+ E + TFG G
Sbjct: 216 RNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVF-----TFGAGG 270
Query: 464 YGDHKPKSST---AAQEVKTLDGIFSEQVAMGYSHS 496
YG S++ ++V L G ++A G H+
Sbjct: 271 YGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHT 306
Score = 98.2 bits (243), Expect = 2e-20
Identities = 62/196 (31%), Positives = 89/196 (45%), Gaps = 25/196 (12%)
Query: 137 WGPHRYG------------------CLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNE 178
WG ++YG L G+ V +G AHS ++T G ++ WGRN+
Sbjct: 161 WGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGG--AHSFVLTLSGAIFGWGRNK 218
Query: 179 KGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGN 238
GQLG D P L++ L + IV CG +HT ALT+ G VF FG GQLG +
Sbjct: 219 FGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNS 278
Query: 239 QTDAVPSPAQIMYNGQPITKMACGAEF-SMIMDCKGNLYSFGCPEYGQLG----HNSDGK 293
+ + G +T++ACG + S + G +YSFG GQLG N
Sbjct: 279 TSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSP 338
Query: 294 FIARAQRIEYDCELVP 309
F + Y+ + +P
Sbjct: 339 FTVKGNWYPYNGQCLP 354
Score = 71.6 bits (174), Expect = 2e-12
Identities = 64/230 (27%), Positives = 100/230 (43%), Gaps = 36/230 (15%)
Query: 278 FGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVAC 337
+G +GQLG I+ + L PR+ FI K VRDV C
Sbjct: 4 WGNASFGQLGLGG----------IDEEIVLEPRKSDFFINKR------------VRDVGC 41
Query: 338 GANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSF 397
G HT+ + V++ G G+LGH +K P V D + + G +
Sbjct: 42 GLRHTVFVLDDGTVYTCGCNDLGQLGH--EKSRKKPEQVVALD--AQNIVAVSCGEAHTL 97
Query: 398 AVSEVGGLFFWGATNT-------SRESTMYPKAVQDLCGWRIRSLACGK-SSIIVAADES 449
A+++ G ++ WG + S E P+ ++ L +I +ACG S+ ++
Sbjct: 98 ALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASE 157
Query: 450 TISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVI 499
WG + +G+LG G K T+ Q +K+L GI QVA G +HS V+
Sbjct: 158 VFCWGQNK-YGQLGLGTDC-KKQTSPQLLKSLLGIPFMQVAAGGAHSFVL 205
Score = 42.0 bits (97), Expect = 0.001
Identities = 37/153 (24%), Positives = 69/153 (45%), Gaps = 7/153 (4%)
Query: 354 WGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNT 413
WG +G+LG +E+V K F + + G + V + G ++ G +
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 414 SR----ESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTI-SWGPSPTFGELGYGDHK 468
+ +S P+ V L I +++CG++ + D+ + +WG G+LG +
Sbjct: 64 GQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSD-GQLGLVGSE 122
Query: 469 PKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIAR 501
+ + +K+L I QVA GY HSL +++
Sbjct: 123 -ECIRVPRNIKSLSDIQIVQVACGYYHSLALSK 154
>gi|4557445 regulator of chromosome condensation and BTB domain
containing protein 2 [Homo sapiens]
Length = 551
Score = 118 bits (296), Expect = 1e-26
Identities = 83/274 (30%), Positives = 132/274 (48%), Gaps = 30/274 (10%)
Query: 139 PHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAP-RLIE 197
P R L G ++ + GS H +L TTEG++++WG N QLG+G T P +
Sbjct: 89 PRRLDSLNGKKIACLSYGS-GPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHIST 147
Query: 198 GLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIM--YNGQP 255
LS++ ++ ACG H+L LT G VFA+G N GQ+G G+ + P P ++ +
Sbjct: 148 NLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQ-PIPRRVTGCLQNKV 206
Query: 256 ITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIF 315
+ +ACG M + G +Y +G GQLG + G + P RVA
Sbjct: 207 VVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGN------------QPTPCRVAA- 253
Query: 316 IEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRL 375
+ + V+ VACG HTLVL + +V++WG YG+LG + ++ P
Sbjct: 254 -----------LQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTP 302
Query: 376 VKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWG 409
V + + ++ +T S A ++ G ++ WG
Sbjct: 303 VTVEKDRIIEIAACHSTHT-SAAKTQGGHVYMWG 335
Score = 106 bits (265), Expect = 5e-23
Identities = 70/239 (29%), Positives = 115/239 (48%), Gaps = 41/239 (17%)
Query: 128 AYRNLGQNLWGPHRYGCLAGVRV--RTVVSGSCAA-HSLLITTEGKLWSWGRNEKGQLGH 184
AY LG C + + V+ +C + HSL++T++G++++WG N GQ+G
Sbjct: 127 AYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGS 186
Query: 185 GDTKRVEAPRLIEG-LSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAV 243
G T PR + G L ++V+V+ ACG+ +A+ +TG V+ +G N GQLGLGN +
Sbjct: 187 GSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQ- 245
Query: 244 PSPAQI-MYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIE 302
P+P ++ G + ++ACG ++++ +G +Y++G YGQLG +
Sbjct: 246 PTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGN------------ 293
Query: 303 YDCELVPRRVAIFIEKTKDGQILPVPNVVVRD-----VACGANHTLVLDSQ-KRVFSWG 355
K Q P P V +D AC + HT +Q V+ WG
Sbjct: 294 -----------------KSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWG 335
Score = 91.7 bits (226), Expect = 2e-18
Identities = 72/270 (26%), Positives = 121/270 (44%), Gaps = 37/270 (13%)
Query: 212 NHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIM-D 270
N L T +F G N G LGLG+ + NG+ I ++ G+ +++
Sbjct: 56 NEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLAT 115
Query: 271 CKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNV 330
+G ++++G Y QLG+ + LVP ++ + N
Sbjct: 116 TEGEVFTWGHNAYSQLGNGTTNH------------GLVPCHISTNLS-----------NK 152
Query: 331 VVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIY 390
V +VACG+ H+LVL S VF+WG+ G++G ++ +PR V + I
Sbjct: 153 QVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRV-TGCLQNKVVVTIA 211
Query: 391 AGYTCSFAVSEVGGLFFWGAT--------NTSRESTMYPKAVQDLCGWRIRSLACGKSSI 442
G C AV + G ++ WG N+ + T P V L G R++ +ACG +
Sbjct: 212 CGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPT--PCRVAALQGIRVQRVACGYAHT 269
Query: 443 IVAADESTI-SWGPSPTFGELGYGDHKPKS 471
+V DE + +WG + ++G+LG G+ +S
Sbjct: 270 LVLTDEGQVYAWGAN-SYGQLGTGNKSNQS 298
Score = 90.1 bits (222), Expect = 4e-18
Identities = 66/267 (24%), Positives = 115/267 (43%), Gaps = 27/267 (10%)
Query: 154 VSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRN- 212
V GS L T +++ G N G LG GD + PR ++ L+ + I + G
Sbjct: 50 VFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGP 109
Query: 213 HTLALTETGSVFAFGENKMGQLGLGNQTDA-VPSPAQIMYNGQPITKMACGAEFSMIMDC 271
H + T G VF +G N QLG G VP + + + ++ACG+ S+++
Sbjct: 110 HIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTS 169
Query: 272 KGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVV 331
G ++++G GQ+G S + +PRRV ++ N V
Sbjct: 170 DGEVFAWGYNNSGQVGSGSTVN------------QPIPRRVTGCLQ-----------NKV 206
Query: 332 VRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYA 391
V +ACG + + V+ WG+ G G+LG ++ P ++ G ++
Sbjct: 207 VVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTP--CRVAALQGIRVQRVAC 264
Query: 392 GYTCSFAVSEVGGLFFWGATNTSREST 418
GY + +++ G ++ WGA + + T
Sbjct: 265 GYAHTLVLTDEGQVYAWGANSYGQLGT 291
Score = 55.1 bits (131), Expect = 2e-07
Identities = 43/173 (24%), Positives = 81/173 (46%), Gaps = 13/173 (7%)
Query: 341 HTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVS 400
H ++ ++ VF+WG Y +LG+ +VP + + + ++ G S ++
Sbjct: 110 HIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHIST-NLSNKQVIEVACGSYHSLVLT 168
Query: 401 EVGGLFFWGATNTSRE---STMYPKAVQDLCGWR----IRSLACGKSSIIVAADESTIS- 452
G +F WG N+ + ST+ + + G + ++ACG+ + D +
Sbjct: 169 SDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYV 228
Query: 453 WGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARDESE 505
WG + G+LG G+ + + V L GI ++VA GY+H+LV+ DE +
Sbjct: 229 WGYNGN-GQLGLGNSGNQPTPC--RVAALQGIRVQRVACGYAHTLVLT-DEGQ 277
>gi|57242759 regulator of chromosome condensation (RCC1) and BTB
(POZ) domain containing protein 1 [Homo sapiens]
Length = 531
Score = 113 bits (283), Expect = 4e-25
Identities = 79/274 (28%), Positives = 136/274 (49%), Gaps = 30/274 (10%)
Query: 139 PHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAP-RLIE 197
P + L G +++++ GS H LL T +G +++WG N QLG+G T + AP ++
Sbjct: 65 PKKLEGLCGKKIKSLSYGS-GPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCT 123
Query: 198 GLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIM--YNGQP 255
L + +V ACG +H++AL G VFA+G N GQ+G G+ + P+P ++ + +
Sbjct: 124 NLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQ-PTPRKVTNCLHIKR 182
Query: 256 ITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIF 315
+ +ACG SM + G +Y +G GQLG ++G +L P RVA
Sbjct: 183 VVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGN------------QLTPVRVAA- 229
Query: 316 IEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRL 375
+ +V V + CG HTL L + +++WG YG+LG + + + P
Sbjct: 230 -----------LHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAH 278
Query: 376 VKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWG 409
+ + + ++ +T S A ++ G ++ WG
Sbjct: 279 IMVEKERVVEIAACHSAHT-SAAKTQGGHVYMWG 311
Score = 106 bits (264), Expect = 6e-23
Identities = 76/277 (27%), Positives = 130/277 (46%), Gaps = 30/277 (10%)
Query: 145 LAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVI 204
+A +R + V G+ A+ +L +T +++ +G N LG GD + P+ +EGL + I
Sbjct: 18 IASIR-KACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKI 76
Query: 205 VSAACGRN-HTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYN--GQPITKMAC 261
S + G H L TE G V+A+G N QLG G + +P Q+ N + + ++AC
Sbjct: 77 KSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGI-APVQVCTNLLIKQVVEVAC 135
Query: 262 GAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKD 321
G+ SM + G ++++G GQ+G S + PR+V
Sbjct: 136 GSHHSMALAADGEVFAWGYNNCGQVGSGSTAN------------QPTPRKVT-------- 175
Query: 322 GQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDF 381
L + VV +ACG ++ + V+ WG+ G G+LG +++ P V++
Sbjct: 176 -NCLHIKRVV--GIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTP--VRVAAL 230
Query: 382 PGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSREST 418
+QI GY + A+++ G L+ WGA + T
Sbjct: 231 HSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGT 267
Score = 77.0 bits (188), Expect = 4e-14
Identities = 69/264 (26%), Positives = 118/264 (44%), Gaps = 35/264 (13%)
Query: 212 NHTLALTETGSVFAFGENKMGQLGLG-NQTDAVPSPAQIMYNGQPITKMACGAEFSMIMD 270
+ L +T+ VF FG N LG G NQ+ VP + + G+ I ++ G+ +++
Sbjct: 32 SEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLC-GKKIKSLSYGSGPHVLLS 90
Query: 271 CK-GNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPN 329
+ G +Y++G Y QLG+ + + IA Q L +
Sbjct: 91 TEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTN---------------------LLIKQ 129
Query: 330 VVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQI 389
VV +VACG++H++ L + VF+WG+ G++G ++ PR V R I
Sbjct: 130 VV--EVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVG-I 186
Query: 390 YAGYTCSFAVSEVGGLFFWGATNT------SRESTMYPKAVQDLCGWRIRSLACGKSSII 443
G T S AV + G ++ WG + + + P V L + + CG + +
Sbjct: 187 ACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTL 246
Query: 444 VAADESTI-SWGPSPTFGELGYGD 466
DE + +WG + T+G+LG G+
Sbjct: 247 ALTDEGLLYAWGAN-TYGQLGTGN 269
Score = 51.2 bits (121), Expect = 2e-06
Identities = 42/167 (25%), Positives = 75/167 (44%), Gaps = 12/167 (7%)
Query: 341 HTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVS 400
H L+ V++WG GY +LG+ + P V + + ++ G S A++
Sbjct: 86 HVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQV-CTNLLIKQVVEVACGSHHSMALA 144
Query: 401 EVGGLFFWGATNT------SRESTMYPKAVQD-LCGWRIRSLACGKSSIIVAADESTI-S 452
G +F WG N S + P+ V + L R+ +ACG++S + D +
Sbjct: 145 ADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYG 204
Query: 453 WGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVI 499
WG + G+LG G++ + + V L + Q+ GY+H+L +
Sbjct: 205 WGYNGN-GQLGLGNNGNQLTPV--RVAALHSVCVNQIVCGYAHTLAL 248
Score = 38.5 bits (88), Expect = 0.015
Identities = 26/92 (28%), Positives = 48/92 (52%), Gaps = 10/92 (10%)
Query: 416 ESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTI--SWGPSPTFGELGYGDHKPKSST 473
+ST+ PK ++ LCG +I+SL+ G ++ + E + +WG + + +LG G ++
Sbjct: 60 QSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHN-GYSQLGNG----TTNQ 114
Query: 474 AAQEVKTLDGIFSEQ---VAMGYSHSLVIARD 502
V+ + +Q VA G HS+ +A D
Sbjct: 115 GIAPVQVCTNLLIKQVVEVACGSHHSMALAAD 146
>gi|110825982 hect domain and RLD 5 [Homo sapiens]
Length = 1024
Score = 111 bits (278), Expect = 1e-24
Identities = 73/221 (33%), Positives = 120/221 (54%), Gaps = 28/221 (12%)
Query: 161 HSLLITTEGKLWSWGRNEKGQLGHGDT-KRVEAPRLIEGLSHEVIVSAACGRNHTLALTE 219
HSL ++ G+L++WG+N GQLG G P+++E L+ + + G H++AL+
Sbjct: 149 HSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSM 208
Query: 220 TGSVFAFGENKMGQLGLGNQTDAVPSPAQIM-YNGQPITKMACGAEFSMIMDCKGNLYSF 278
+G+++++G+N+ GQLGLG+ T++ P+ I + Q + +ACG S ++ G L++F
Sbjct: 209 SGNIYSWGKNECGQLGLGH-TESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTF 267
Query: 279 GCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACG 338
G ++GQLGHNS EL P VA + V +ACG
Sbjct: 268 GAGKHGQLGHNSTQN------------ELRPCLVAELV------------GYRVTQIACG 303
Query: 339 ANHTLVLDSQ-KRVFSWGFGGYGRLGHAEQKDEMVPRLVKL 378
HTL S +VFS+G G G+LG+ +D+++P VK+
Sbjct: 304 RWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKV 344
Score = 98.6 bits (244), Expect = 1e-20
Identities = 74/265 (27%), Positives = 129/265 (48%), Gaps = 41/265 (15%)
Query: 148 VRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSA 207
+++ +V G A H L+++++GK + + D ++ R L + I+
Sbjct: 97 MKIHSVDQG--AEHMLILSSDGKPFEY-----------DNYSMKHLRFESILQEKKIIQI 143
Query: 208 ACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMY-NGQPITKMACGAEFS 266
CG H+LAL++ G +FA+G+N GQLG+G + + +P + + G P+ +++ G S
Sbjct: 144 TCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHS 203
Query: 267 MIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILP 326
M + GN+YS+G E GQLG + K I
Sbjct: 204 MALSMSGNIYSWGKNECGQLG------------------------LGHTESKDDPSLIEG 239
Query: 327 VPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGA 386
+ N V VACG +H+ +L +F++G G +G+LGH ++E+ P LV + G
Sbjct: 240 LDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVA--ELVGYRV 297
Query: 387 SQIYAGYTCSFA-VSEVGGLFFWGA 410
+QI G + A VS++G +F +G+
Sbjct: 298 TQIACGRWHTLAYVSDLGKVFSFGS 322
Score = 98.2 bits (243), Expect = 2e-20
Identities = 54/145 (37%), Positives = 85/145 (58%), Gaps = 3/145 (2%)
Query: 145 LAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVI 204
LAGV + + +G AHS+ ++ G ++SWG+NE GQLG G T+ + P LIEGL ++ +
Sbjct: 188 LAGVPLAQISAGE--AHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKV 245
Query: 205 VSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAE 264
ACG +H+ LT+ G +F FG K GQLG + + + G +T++ACG
Sbjct: 246 EFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRW 305
Query: 265 FSM-IMDCKGNLYSFGCPEYGQLGH 288
++ + G ++SFG + GQLG+
Sbjct: 306 HTLAYVSDLGKVFSFGSGKDGQLGN 330
Score = 63.5 bits (153), Expect = 4e-10
Identities = 73/347 (21%), Positives = 142/347 (40%), Gaps = 55/347 (15%)
Query: 193 PRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYN 252
P+ I+ + I S G H L L+ G F + M L + +
Sbjct: 88 PKCIKLGKNMKIHSVDQGAEHMLILSSDGKPFEYDNYSMKHLRF-----------ESILQ 136
Query: 253 GQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRV 312
+ I ++ CG S+ + G L+++G +GQLG Q +E+
Sbjct: 137 EKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEH--------- 187
Query: 313 AIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGR--LGHAEQKDE 370
+ V + ++ G H++ L ++SWG G+ LGH E KD+
Sbjct: 188 --------------LAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDD 233
Query: 371 MVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGA------TNTSRESTMYPKAV 424
P L++ D + + G + S +++ G LF +GA + S ++ + P V
Sbjct: 234 --PSLIEGLD--NQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLV 289
Query: 425 QDLCGWRIRSLACGK-SSIIVAADESTISWGPSPTFGELGYGDHK------PKSSTAAQE 477
+L G+R+ +ACG+ ++ +D + S G+LG G + P ++++E
Sbjct: 290 AELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEE 349
Query: 478 VKTLDGIFSEQVAM--GYSHSLVIARDESETEKEKIKKLPEYNPRTL 522
+K +++ M G + S+++ + + + +P N T+
Sbjct: 350 LKLESHTSEKELIMIAGGNQSILLWIKKENSYVNLKRTIPTLNEGTV 396
Score = 32.7 bits (73), Expect = 0.83
Identities = 30/100 (30%), Positives = 43/100 (43%), Gaps = 14/100 (14%)
Query: 104 GQLLIFGATNWDLIGRKEVPKQQAAYRNLGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSL 163
G L FGA +G N QN P L G RV + G H+L
Sbjct: 262 GLLFTFGAGKHGQLGH-----------NSTQNELRPCLVAELVGYRVTQIACGRW--HTL 308
Query: 164 LITTE-GKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHE 202
++ GK++S+G + GQLG+G T+ P ++ S E
Sbjct: 309 AYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSE 348
>gi|61563742 hect domain and RLD 6 [Homo sapiens]
Length = 1022
Score = 106 bits (264), Expect = 6e-23
Identities = 76/269 (28%), Positives = 129/269 (47%), Gaps = 27/269 (10%)
Query: 161 HSLLITTEGKLWSWGRNEKGQLGHGDTKRVE-APRLIEGLSHEVIVSAACGRNHTLALTE 219
HSL + +G++++WG +GQLG G+ K + P+ I L+ I+ +CG H+LAL++
Sbjct: 86 HSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSK 145
Query: 220 TGSVFAFGENKMGQLGLGNQTDAVPSPAQIM-YNGQPITKMACGAEFSMIMDCKGNLYSF 278
VF++G+N GQLGLG + + SP ++ G P+ ++A G S + G + +
Sbjct: 146 DSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGW 205
Query: 279 GCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACG 338
G GQL L R V + + K + + N+ V ++CG
Sbjct: 206 GSNSAGQLA-------------------LSGRNVPV--QSNKPLSVGALKNLGVVYISCG 244
Query: 339 ANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAG-YTCSF 397
HT VL +VF++G G+LG++ ++ P+LV+ D SQI G Y
Sbjct: 245 DAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERID---GLVSQIDCGSYHTLA 301
Query: 398 AVSEVGGLFFWGATNTSRESTMYPKAVQD 426
V G + +G + +P+A+ +
Sbjct: 302 YVHTTGQVVSFGHGPSDTSKPTHPEALTE 330
Score = 94.0 bits (232), Expect = 3e-19
Identities = 81/305 (26%), Positives = 137/305 (44%), Gaps = 40/305 (13%)
Query: 204 IVSAACGRNHTLALTETGSVFAFGENKMGQLG-LGNQTDAVPSPAQIMYNGQPITKMACG 262
++ AA G H+L L V + G+N GQLG G Q +P P Q + + ++CG
Sbjct: 25 LLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQAL-ETLIVDLVSCG 83
Query: 263 AEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDG 322
E S+ + KG ++++G GQLG I + I + P++
Sbjct: 84 KEHSLAVCHKGRVFAWGAGSEGQLG-------IGEFKEISF----TPKK----------- 121
Query: 323 QILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQ-KDEMVPRLVKLFDF 381
I+ + ++ + V+CG H+L L +VFSWG +G+LG ++ + P+ V+ +
Sbjct: 122 -IMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLE- 179
Query: 382 PGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR---------ESTMYPKAVQDLCGWRI 432
G +Q+ AG SFA+S G F WG+ + + + P +V L +
Sbjct: 180 -GIPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGV 238
Query: 433 RSLACGKSSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMG 492
++CG + V + + G+LGY K Q V+ +DG+ S Q+ G
Sbjct: 239 VYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEK--RGPQLVERIDGLVS-QIDCG 295
Query: 493 YSHSL 497
H+L
Sbjct: 296 SYHTL 300
Score = 67.8 bits (164), Expect = 2e-11
Identities = 52/181 (28%), Positives = 84/181 (46%), Gaps = 12/181 (6%)
Query: 328 PNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGAS 387
P + A G H+L+L + RV S G G+LG + +P ++ +
Sbjct: 21 PGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALE--TLIVD 78
Query: 388 QIYAGYTCSFAVSEVGGLFFWGATNTS-------RESTMYPKAVQDLCGWRIRSLACGK- 439
+ G S AV G +F WGA + +E + PK + L +I ++CG
Sbjct: 79 LVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHY 138
Query: 440 SSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVI 499
S+ ++ D SWG + + G+LG G P S + Q V++L+GI QVA G +HS +
Sbjct: 139 HSLALSKDSQVFSWGKN-SHGQLGLGKEFP-SQASPQRVRSLEGIPLAQVAAGGAHSFAL 196
Query: 500 A 500
+
Sbjct: 197 S 197
Score = 65.5 bits (158), Expect = 1e-10
Identities = 44/145 (30%), Positives = 69/145 (47%), Gaps = 7/145 (4%)
Query: 139 PHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQL---GHGDTKRVEAPRL 195
P R L G+ + V +G AHS ++ G + WG N GQL G + P
Sbjct: 172 PQRVRSLEGIPLAQVAAGG--AHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLS 229
Query: 196 IEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQP 255
+ L + +V +CG HT LT+ G VF FG+N+ GQLG + T P +
Sbjct: 230 VGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGY-SPTPEKRGPQLVERIDGL 288
Query: 256 ITKMACGAEFSM-IMDCKGNLYSFG 279
++++ CG+ ++ + G + SFG
Sbjct: 289 VSQIDCGSYHTLAYVHTTGQVVSFG 313
Score = 59.7 bits (143), Expect = 6e-09
Identities = 65/260 (25%), Positives = 110/260 (42%), Gaps = 37/260 (14%)
Query: 253 GQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRV 312
G + + A G S+++ + S G GQLG AQR E +P
Sbjct: 22 GAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRG-------AQRGE-----LPE-- 67
Query: 313 AIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKD-EM 371
I + ++V V+CG H+L + + RVF+WG G G+LG E K+
Sbjct: 68 ----------PIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISF 117
Query: 372 VPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR-------ESTMYPKAV 424
P+ K+ Q+ G+ S A+S+ +F WG + + S P+ V
Sbjct: 118 TPK--KIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRV 175
Query: 425 QDLCGWRIRSLACGKS-SIIVAADESTISWGPSPTFGELGY-GDHKPKSSTAAQEVKTLD 482
+ L G + +A G + S ++ ++ WG S + G+L G + P S V L
Sbjct: 176 RSLEGIPLAQVAAGGAHSFALSLCGTSFGWG-SNSAGQLALSGRNVPVQSNKPLSVGALK 234
Query: 483 GIFSEQVAMGYSHSLVIARD 502
+ ++ G +H+ V+ +D
Sbjct: 235 NLGVVYISCGDAHTAVLTQD 254
>gi|114796646 regulator of chromosome condensation 1 isoform b [Homo
sapiens]
Length = 438
Score = 104 bits (259), Expect = 2e-22
Identities = 96/387 (24%), Positives = 170/387 (43%), Gaps = 27/387 (6%)
Query: 132 LGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVE 191
LG+N+ + L + V + + H++ ++ G+++S+G N++G LG DT VE
Sbjct: 67 LGENVM-ERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGR-DTS-VE 123
Query: 192 APRLIEGLSH--EVIVSAACGRNHTLALTETGSVFAFGE--NKMGQLGLGNQTDAVPSPA 247
++ G E +V + G +HT ALT+ G VF +G + G +GL P
Sbjct: 124 GSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV 183
Query: 248 QIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCEL 307
Q+ + P+ K+A G + +++ G+LY+ GC E GQLG + F R R + L
Sbjct: 184 QVQLD-VPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE-LFANRGGRQGLERLL 241
Query: 308 VPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQ 367
VP+ V + K++ + +V +D CGA T + + V+ +G Y +LG
Sbjct: 242 VPKCVML---KSRGSR----GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGT 294
Query: 368 KDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR-------ESTMY 420
+ +P+ + F + G + + G + G R E
Sbjct: 295 ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSI 354
Query: 421 PKAVQDLCGWRIRSLACGKS-SIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVK 479
P + L + S+ACG S V D +WG + +LG G + S K
Sbjct: 355 PTLISRLPA--VSSVACGASVGYAVTKDGRVFAWGMGTNY-QLGTGQDEDAWSPVEMMGK 411
Query: 480 TLDGIFSEQVAMGYSHSLVIARDESET 506
L+ V+ G H++++ +D+ ++
Sbjct: 412 QLENRVVLSVSSGGQHTVLLVKDKEQS 438
Score = 59.3 bits (142), Expect = 8e-09
Identities = 51/182 (28%), Positives = 75/182 (41%), Gaps = 28/182 (15%)
Query: 200 SHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKM 259
S V + +C +H TE G V G+ +GQLGLG PA + + + +
Sbjct: 31 SRRVPGARSCQVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQA 89
Query: 260 ACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKT 319
G ++ + G +YSFGC + G LG ++ + E+VP +V +
Sbjct: 90 EAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVE----------GSEMVPGKVEL----- 134
Query: 320 KDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGF--GGYGRLGHAE-QKDEMVPRLV 376
V V+ G +HT L RVF WG G +G E K MVP V
Sbjct: 135 ---------QEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQV 185
Query: 377 KL 378
+L
Sbjct: 186 QL 187
>gi|114796644 regulator of chromosome condensation 1 isoform a [Homo
sapiens]
Length = 452
Score = 104 bits (259), Expect = 2e-22
Identities = 96/387 (24%), Positives = 170/387 (43%), Gaps = 27/387 (6%)
Query: 132 LGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVE 191
LG+N+ + L + V + + H++ ++ G+++S+G N++G LG DT VE
Sbjct: 81 LGENVM-ERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGR-DTS-VE 137
Query: 192 APRLIEGLSH--EVIVSAACGRNHTLALTETGSVFAFGE--NKMGQLGLGNQTDAVPSPA 247
++ G E +V + G +HT ALT+ G VF +G + G +GL P
Sbjct: 138 GSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV 197
Query: 248 QIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCEL 307
Q+ + P+ K+A G + +++ G+LY+ GC E GQLG + F R R + L
Sbjct: 198 QVQLD-VPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE-LFANRGGRQGLERLL 255
Query: 308 VPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQ 367
VP+ V + K++ + +V +D CGA T + + V+ +G Y +LG
Sbjct: 256 VPKCVML---KSRGSR----GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGT 308
Query: 368 KDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR-------ESTMY 420
+ +P+ + F + G + + G + G R E
Sbjct: 309 ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSI 368
Query: 421 PKAVQDLCGWRIRSLACGKS-SIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVK 479
P + L + S+ACG S V D +WG + +LG G + S K
Sbjct: 369 PTLISRLPA--VSSVACGASVGYAVTKDGRVFAWGMGTNY-QLGTGQDEDAWSPVEMMGK 425
Query: 480 TLDGIFSEQVAMGYSHSLVIARDESET 506
L+ V+ G H++++ +D+ ++
Sbjct: 426 QLENRVVLSVSSGGQHTVLLVKDKEQS 452
Score = 56.6 bits (135), Expect = 5e-08
Identities = 48/170 (28%), Positives = 70/170 (41%), Gaps = 28/170 (16%)
Query: 212 NHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDC 271
+H TE G V G+ +GQLGLG PA + + + + G ++ +
Sbjct: 57 SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAGGMHTVCLSK 115
Query: 272 KGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVV 331
G +YSFGC + G LG ++ + E+VP +V +
Sbjct: 116 SGQVYSFGCNDEGALGRDTSVE----------GSEMVPGKVEL--------------QEK 151
Query: 332 VRDVACGANHTLVLDSQKRVFSWGF--GGYGRLGHAE-QKDEMVPRLVKL 378
V V+ G +HT L RVF WG G +G E K MVP V+L
Sbjct: 152 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL 201
>gi|4502801 regulator of chromosome condensation 1 isoform c [Homo
sapiens]
Length = 421
Score = 104 bits (259), Expect = 2e-22
Identities = 96/387 (24%), Positives = 170/387 (43%), Gaps = 27/387 (6%)
Query: 132 LGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVE 191
LG+N+ + L + V + + H++ ++ G+++S+G N++G LG DT VE
Sbjct: 50 LGENVM-ERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGR-DTS-VE 106
Query: 192 APRLIEGLSH--EVIVSAACGRNHTLALTETGSVFAFGE--NKMGQLGLGNQTDAVPSPA 247
++ G E +V + G +HT ALT+ G VF +G + G +GL P
Sbjct: 107 GSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV 166
Query: 248 QIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCEL 307
Q+ + P+ K+A G + +++ G+LY+ GC E GQLG + F R R + L
Sbjct: 167 QVQLD-VPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE-LFANRGGRQGLERLL 224
Query: 308 VPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQ 367
VP+ V + K++ + +V +D CGA T + + V+ +G Y +LG
Sbjct: 225 VPKCVML---KSRGSR----GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGT 277
Query: 368 KDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR-------ESTMY 420
+ +P+ + F + G + + G + G R E
Sbjct: 278 ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSI 337
Query: 421 PKAVQDLCGWRIRSLACGKS-SIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVK 479
P + L + S+ACG S V D +WG + +LG G + S K
Sbjct: 338 PTLISRLPA--VSSVACGASVGYAVTKDGRVFAWGMGTNY-QLGTGQDEDAWSPVEMMGK 394
Query: 480 TLDGIFSEQVAMGYSHSLVIARDESET 506
L+ V+ G H++++ +D+ ++
Sbjct: 395 QLENRVVLSVSSGGQHTVLLVKDKEQS 421
Score = 56.6 bits (135), Expect = 5e-08
Identities = 48/170 (28%), Positives = 70/170 (41%), Gaps = 28/170 (16%)
Query: 212 NHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDC 271
+H TE G V G+ +GQLGLG PA + + + + G ++ +
Sbjct: 26 SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAGGMHTVCLSK 84
Query: 272 KGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVV 331
G +YSFGC + G LG ++ + E+VP +V +
Sbjct: 85 SGQVYSFGCNDEGALGRDTSVE----------GSEMVPGKVEL--------------QEK 120
Query: 332 VRDVACGANHTLVLDSQKRVFSWGF--GGYGRLGHAE-QKDEMVPRLVKL 378
V V+ G +HT L RVF WG G +G E K MVP V+L
Sbjct: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL 170
>gi|114796642 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 104 bits (259), Expect = 2e-22
Identities = 96/387 (24%), Positives = 170/387 (43%), Gaps = 27/387 (6%)
Query: 132 LGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVE 191
LG+N+ + L + V + + H++ ++ G+++S+G N++G LG DT VE
Sbjct: 50 LGENVM-ERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGR-DTS-VE 106
Query: 192 APRLIEGLSH--EVIVSAACGRNHTLALTETGSVFAFGE--NKMGQLGLGNQTDAVPSPA 247
++ G E +V + G +HT ALT+ G VF +G + G +GL P
Sbjct: 107 GSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV 166
Query: 248 QIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCEL 307
Q+ + P+ K+A G + +++ G+LY+ GC E GQLG + F R R + L
Sbjct: 167 QVQLD-VPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE-LFANRGGRQGLERLL 224
Query: 308 VPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQ 367
VP+ V + K++ + +V +D CGA T + + V+ +G Y +LG
Sbjct: 225 VPKCVML---KSRGSR----GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGT 277
Query: 368 KDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR-------ESTMY 420
+ +P+ + F + G + + G + G R E
Sbjct: 278 ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSI 337
Query: 421 PKAVQDLCGWRIRSLACGKS-SIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVK 479
P + L + S+ACG S V D +WG + +LG G + S K
Sbjct: 338 PTLISRLPA--VSSVACGASVGYAVTKDGRVFAWGMGTNY-QLGTGQDEDAWSPVEMMGK 394
Query: 480 TLDGIFSEQVAMGYSHSLVIARDESET 506
L+ V+ G H++++ +D+ ++
Sbjct: 395 QLENRVVLSVSSGGQHTVLLVKDKEQS 421
Score = 56.6 bits (135), Expect = 5e-08
Identities = 48/170 (28%), Positives = 70/170 (41%), Gaps = 28/170 (16%)
Query: 212 NHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDC 271
+H TE G V G+ +GQLGLG PA + + + + G ++ +
Sbjct: 26 SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAGGMHTVCLSK 84
Query: 272 KGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVV 331
G +YSFGC + G LG ++ + E+VP +V +
Sbjct: 85 SGQVYSFGCNDEGALGRDTSVE----------GSEMVPGKVEL--------------QEK 120
Query: 332 VRDVACGANHTLVLDSQKRVFSWGF--GGYGRLGHAE-QKDEMVPRLVKL 378
V V+ G +HT L RVF WG G +G E K MVP V+L
Sbjct: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL 170
>gi|114796640 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 104 bits (259), Expect = 2e-22
Identities = 96/387 (24%), Positives = 170/387 (43%), Gaps = 27/387 (6%)
Query: 132 LGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVE 191
LG+N+ + L + V + + H++ ++ G+++S+G N++G LG DT VE
Sbjct: 50 LGENVM-ERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGR-DTS-VE 106
Query: 192 APRLIEGLSH--EVIVSAACGRNHTLALTETGSVFAFGE--NKMGQLGLGNQTDAVPSPA 247
++ G E +V + G +HT ALT+ G VF +G + G +GL P
Sbjct: 107 GSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV 166
Query: 248 QIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCEL 307
Q+ + P+ K+A G + +++ G+LY+ GC E GQLG + F R R + L
Sbjct: 167 QVQLD-VPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE-LFANRGGRQGLERLL 224
Query: 308 VPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQ 367
VP+ V + K++ + +V +D CGA T + + V+ +G Y +LG
Sbjct: 225 VPKCVML---KSRGSR----GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGT 277
Query: 368 KDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR-------ESTMY 420
+ +P+ + F + G + + G + G R E
Sbjct: 278 ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSI 337
Query: 421 PKAVQDLCGWRIRSLACGKS-SIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVK 479
P + L + S+ACG S V D +WG + +LG G + S K
Sbjct: 338 PTLISRLPA--VSSVACGASVGYAVTKDGRVFAWGMGTNY-QLGTGQDEDAWSPVEMMGK 394
Query: 480 TLDGIFSEQVAMGYSHSLVIARDESET 506
L+ V+ G H++++ +D+ ++
Sbjct: 395 QLENRVVLSVSSGGQHTVLLVKDKEQS 421
Score = 56.6 bits (135), Expect = 5e-08
Identities = 48/170 (28%), Positives = 70/170 (41%), Gaps = 28/170 (16%)
Query: 212 NHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDC 271
+H TE G V G+ +GQLGLG PA + + + + G ++ +
Sbjct: 26 SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAGGMHTVCLSK 84
Query: 272 KGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVV 331
G +YSFGC + G LG ++ + E+VP +V +
Sbjct: 85 SGQVYSFGCNDEGALGRDTSVE----------GSEMVPGKVEL--------------QEK 120
Query: 332 VRDVACGANHTLVLDSQKRVFSWGF--GGYGRLGHAE-QKDEMVPRLVKL 378
V V+ G +HT L RVF WG G +G E K MVP V+L
Sbjct: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL 170
>gi|114796648 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 104 bits (259), Expect = 2e-22
Identities = 96/387 (24%), Positives = 170/387 (43%), Gaps = 27/387 (6%)
Query: 132 LGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVE 191
LG+N+ + L + V + + H++ ++ G+++S+G N++G LG DT VE
Sbjct: 50 LGENVM-ERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGR-DTS-VE 106
Query: 192 APRLIEGLSH--EVIVSAACGRNHTLALTETGSVFAFGE--NKMGQLGLGNQTDAVPSPA 247
++ G E +V + G +HT ALT+ G VF +G + G +GL P
Sbjct: 107 GSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV 166
Query: 248 QIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCEL 307
Q+ + P+ K+A G + +++ G+LY+ GC E GQLG + F R R + L
Sbjct: 167 QVQLD-VPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE-LFANRGGRQGLERLL 224
Query: 308 VPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQ 367
VP+ V + K++ + +V +D CGA T + + V+ +G Y +LG
Sbjct: 225 VPKCVML---KSRGSR----GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGT 277
Query: 368 KDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR-------ESTMY 420
+ +P+ + F + G + + G + G R E
Sbjct: 278 ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSI 337
Query: 421 PKAVQDLCGWRIRSLACGKS-SIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVK 479
P + L + S+ACG S V D +WG + +LG G + S K
Sbjct: 338 PTLISRLPA--VSSVACGASVGYAVTKDGRVFAWGMGTNY-QLGTGQDEDAWSPVEMMGK 394
Query: 480 TLDGIFSEQVAMGYSHSLVIARDESET 506
L+ V+ G H++++ +D+ ++
Sbjct: 395 QLENRVVLSVSSGGQHTVLLVKDKEQS 421
Score = 56.6 bits (135), Expect = 5e-08
Identities = 48/170 (28%), Positives = 70/170 (41%), Gaps = 28/170 (16%)
Query: 212 NHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDC 271
+H TE G V G+ +GQLGLG PA + + + + G ++ +
Sbjct: 26 SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAGGMHTVCLSK 84
Query: 272 KGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVV 331
G +YSFGC + G LG ++ + E+VP +V +
Sbjct: 85 SGQVYSFGCNDEGALGRDTSVE----------GSEMVPGKVEL--------------QEK 120
Query: 332 VRDVACGANHTLVLDSQKRVFSWGF--GGYGRLGHAE-QKDEMVPRLVKL 378
V V+ G +HT L RVF WG G +G E K MVP V+L
Sbjct: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL 170
>gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo
sapiens]
Length = 815
Score = 97.4 bits (241), Expect = 3e-20
Identities = 81/323 (25%), Positives = 143/323 (44%), Gaps = 40/323 (12%)
Query: 161 HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTET 220
HS ++T KL+ +G N GQLG G + P ++ L E + AACGRNHTL TE
Sbjct: 46 HSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEG 105
Query: 221 GSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQ-PITKMACGAEFSMIMDCKGNLYSFG 279
G+V+A G N GQLGLG+ + + + I +++ G+ S + G L+ +G
Sbjct: 106 GNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWG 165
Query: 280 CPEYGQLG-----------HNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVP 328
GQ+G + GK ++ Y V +++ + L +P
Sbjct: 166 DNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLP 225
Query: 329 NVV----------------VRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDE-M 371
N + V VACG HT+VL ++ V+++G G +G+LG E
Sbjct: 226 NQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVL-TENAVYTFGLGQFGQLGLGTFLFETS 284
Query: 372 VPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR--------ESTMYPKA 423
P++++ + + S I G + ++++G ++ +G + + P
Sbjct: 285 EPKVIE--NIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTL 342
Query: 424 VQDLCGWRIRSLACGKSSIIVAA 446
+ + ++ +ACG ++V A
Sbjct: 343 CSNFLRFIVKLVACGGCHMVVFA 365
Score = 77.8 bits (190), Expect = 2e-14
Identities = 72/311 (23%), Positives = 136/311 (43%), Gaps = 46/311 (14%)
Query: 201 HEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQI-MYNGQPITKM 259
++V V +CG H+ +T ++ FG N GQLGLG+++ A+ P + + +
Sbjct: 34 NDVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKS-AISKPTCVKALKPEKVKLA 92
Query: 260 ACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKT 319
ACG +++ GN+Y+ G GQLG +R + ++ F +
Sbjct: 93 ACGRNHTLVSTEGGNVYATGGNNEGQLGLGD------TEERNTFHV------ISFFTSEH 140
Query: 320 KDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLF 379
K ++ ++ G+N + L R+F WG G++G + VP+ V +
Sbjct: 141 K-----------IKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI- 188
Query: 380 DFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR--------ESTMYPKAVQDLCGWR 431
G+ S I GY S V+ G L+ +G + + P+ V ++ +
Sbjct: 189 ---GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEI-PEK 244
Query: 432 IRSLACGKSSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSE---Q 488
+ +ACG +V + + ++G FG+LG G ++S E K ++ I +
Sbjct: 245 VIQVACGGEHTVVLTENAVYTFGLG-QFGQLGLGTFLFETS----EPKVIENIRDQTISY 299
Query: 489 VAMGYSHSLVI 499
++ G +H+ +I
Sbjct: 300 ISCGENHTALI 310
Score = 72.4 bits (176), Expect = 9e-13
Identities = 73/299 (24%), Positives = 123/299 (41%), Gaps = 58/299 (19%)
Query: 217 LTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLY 276
+ ++G+VF FG++K + +P + + ++CG E S ++ LY
Sbjct: 8 MPDSGAVFTFGKSKFAE----------NNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLY 57
Query: 277 SFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVA 336
FG +GQLG S I++ ++ L P +V + A
Sbjct: 58 MFGSNNWGQLGLGSKSA-ISKPTCVK---ALKPEKVKL--------------------AA 93
Query: 337 CGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCS 396
CG NHTLV V++ G G+LG + ++ ++ F + Q+ AG S
Sbjct: 94 CGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHK-IKQLSAGSNTS 152
Query: 397 FAVSEVGGLFFWGATNTSRESTMYPKAVQDLC-------GWRIRSLACG-KSSIIVAADE 448
A++E G LF WG + E + K V ++C G + ++CG S V D
Sbjct: 153 AALTEDGRLFMWG---DNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDG 209
Query: 449 STISWGPSPTFGELG-----YGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARD 502
+G P G+LG G+H+ + K + QVA G H++V+ +
Sbjct: 210 ELYVFG-EPENGKLGLPNQLLGNHRTPQLVSEIPEKVI------QVACGGEHTVVLTEN 261
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 97.4 bits (241), Expect = 3e-20
Identities = 81/323 (25%), Positives = 143/323 (44%), Gaps = 40/323 (12%)
Query: 161 HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTET 220
HS ++T KL+ +G N GQLG G + P ++ L E + AACGRNHTL TE
Sbjct: 46 HSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEG 105
Query: 221 GSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQ-PITKMACGAEFSMIMDCKGNLYSFG 279
G+V+A G N GQLGLG+ + + + I +++ G+ S + G L+ +G
Sbjct: 106 GNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWG 165
Query: 280 CPEYGQLG-----------HNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVP 328
GQ+G + GK ++ Y V +++ + L +P
Sbjct: 166 DNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLP 225
Query: 329 NVV----------------VRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDE-M 371
N + V VACG HT+VL ++ V+++G G +G+LG E
Sbjct: 226 NQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVL-TENAVYTFGLGQFGQLGLGTFLFETS 284
Query: 372 VPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR--------ESTMYPKA 423
P++++ + + S I G + ++++G ++ +G + + P
Sbjct: 285 EPKVIE--NIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTL 342
Query: 424 VQDLCGWRIRSLACGKSSIIVAA 446
+ + ++ +ACG ++V A
Sbjct: 343 CSNFLRFIVKLVACGGCHMVVFA 365
Score = 77.8 bits (190), Expect = 2e-14
Identities = 72/311 (23%), Positives = 136/311 (43%), Gaps = 46/311 (14%)
Query: 201 HEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQI-MYNGQPITKM 259
++V V +CG H+ +T ++ FG N GQLGLG+++ A+ P + + +
Sbjct: 34 NDVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKS-AISKPTCVKALKPEKVKLA 92
Query: 260 ACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKT 319
ACG +++ GN+Y+ G GQLG +R + ++ F +
Sbjct: 93 ACGRNHTLVSTEGGNVYATGGNNEGQLGLGD------TEERNTFHV------ISFFTSEH 140
Query: 320 KDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLF 379
K ++ ++ G+N + L R+F WG G++G + VP+ V +
Sbjct: 141 K-----------IKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI- 188
Query: 380 DFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSR--------ESTMYPKAVQDLCGWR 431
G+ S I GY S V+ G L+ +G + + P+ V ++ +
Sbjct: 189 ---GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEI-PEK 244
Query: 432 IRSLACGKSSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSE---Q 488
+ +ACG +V + + ++G FG+LG G ++S E K ++ I +
Sbjct: 245 VIQVACGGEHTVVLTENAVYTFGLG-QFGQLGLGTFLFETS----EPKVIENIRDQTISY 299
Query: 489 VAMGYSHSLVI 499
++ G +H+ +I
Sbjct: 300 ISCGENHTALI 310
Score = 72.4 bits (176), Expect = 9e-13
Identities = 73/299 (24%), Positives = 123/299 (41%), Gaps = 58/299 (19%)
Query: 217 LTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLY 276
+ ++G+VF FG++K + +P + + ++CG E S ++ LY
Sbjct: 8 MPDSGAVFTFGKSKFAE----------NNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLY 57
Query: 277 SFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVA 336
FG +GQLG S I++ ++ L P +V + A
Sbjct: 58 MFGSNNWGQLGLGSKSA-ISKPTCVK---ALKPEKVKL--------------------AA 93
Query: 337 CGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCS 396
CG NHTLV V++ G G+LG + ++ ++ F + Q+ AG S
Sbjct: 94 CGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHK-IKQLSAGSNTS 152
Query: 397 FAVSEVGGLFFWGATNTSRESTMYPKAVQDLC-------GWRIRSLACG-KSSIIVAADE 448
A++E G LF WG + E + K V ++C G + ++CG S V D
Sbjct: 153 AALTEDGRLFMWG---DNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDG 209
Query: 449 STISWGPSPTFGELG-----YGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARD 502
+G P G+LG G+H+ + K + QVA G H++V+ +
Sbjct: 210 ELYVFG-EPENGKLGLPNQLLGNHRTPQLVSEIPEKVI------QVACGGEHTVVLTEN 261
>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
Length = 979
Score = 93.2 bits (230), Expect = 5e-19
Identities = 82/337 (24%), Positives = 146/337 (43%), Gaps = 56/337 (16%)
Query: 146 AGVRVRTVVSGSCAAHSLLITTEGKLWSW-----GRNEKGQLGHGDTKRVEAPRLIEGLS 200
+G R V +G+ H ++T E +L++W G GQLGHGD P+ +E L
Sbjct: 367 SGCSARQVCAGN--THFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQ 424
Query: 201 HEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQT-DAVPSPAQI-MYNGQPITK 258
+ I +CG + T+ +T+ G ++AFG + G +G+ V P Q+ + P+ +
Sbjct: 425 GKAIRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQ 484
Query: 259 MACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEK 318
++CG +++ +YS+GC EYG+LG +S+ + Q+++ VP+
Sbjct: 485 VSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYT-PQKVD-----VPKA------- 531
Query: 319 TKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPR---- 374
+++ V CG + T +L +V + G + +LG + ++
Sbjct: 532 -----------LIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYH 580
Query: 375 ---------LVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSREST-MYPKAV 424
L K F I G T + A+ E G L +G + Y K +
Sbjct: 581 EVPYTTSFTLAKQLSF--YKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRL 638
Query: 425 ------QDLCGWRIRSLACGKSSIIVAADESTI-SWG 454
L G ++ ++CG I A D++ I +WG
Sbjct: 639 GINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWG 675
Score = 73.6 bits (179), Expect = 4e-13
Identities = 69/273 (25%), Positives = 109/273 (39%), Gaps = 47/273 (17%)
Query: 103 KGQLLIFGATNWDLIGRKEVPKQQAAYRNLGQNLWGPHRYGCLAGVRVRTVVSGSCAAHS 162
+GQL FG+ + +G +V G + P + V V G H
Sbjct: 444 EGQLYAFGSDYYGCMGVDKVA---------GPEVLEPMQLNFFLSNPVEQVSCGD--NHV 492
Query: 163 LLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGS 222
+++T +++SWG E G+LG + P+ ++ +IV+ CG + T LT++G
Sbjct: 493 VVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGK 552
Query: 223 VFAFGENKMGQLGLGNQTDA---------VPSPAQIMYNGQ----PITKMACGAEFSMIM 269
V A G N+ +LGL VP Q I +A G + +
Sbjct: 553 VLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAI 612
Query: 270 DCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPN 329
D +G L +FGC + GQLG + +R+ I + P+
Sbjct: 613 DERGRLLTFGCNKCGQLGVGN-----------------YKKRLGINLLGG------PLGG 649
Query: 330 VVVRDVACGANHTLVLDSQKRVFSWGFGGYGRL 362
V V+CG T+ +F+WG GG GRL
Sbjct: 650 KQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRL 682
Score = 51.2 bits (121), Expect = 2e-06
Identities = 29/93 (31%), Positives = 51/93 (54%), Gaps = 3/93 (3%)
Query: 145 LAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEG-LSHEV 203
L+ ++RT+ G H+ I G+L ++G N+ GQLG G+ K+ L+ G L +
Sbjct: 594 LSFYKIRTIAPGK--THTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQ 651
Query: 204 IVSAACGRNHTLALTETGSVFAFGENKMGQLGL 236
++ +CG T+A T+ +FA+G G+L +
Sbjct: 652 VIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAM 684
Score = 34.7 bits (78), Expect = 0.22
Identities = 33/132 (25%), Positives = 52/132 (39%), Gaps = 11/132 (8%)
Query: 383 GRGASQIYAGYTCSFAVSEVGGLFFW----GATNT-------SRESTMYPKAVQDLCGWR 431
G A Q+ AG T V+ L+ W G T + S PK V+ L G
Sbjct: 368 GCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKA 427
Query: 432 IRSLACGKSSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAM 491
IR ++CG + DE + S +G +G ++ EQV+
Sbjct: 428 IRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSC 487
Query: 492 GYSHSLVIARDE 503
G +H +V+ R++
Sbjct: 488 GDNHVVVLTRNK 499
Score = 34.3 bits (77), Expect = 0.28
Identities = 35/124 (28%), Positives = 50/124 (40%), Gaps = 20/124 (16%)
Query: 103 KGQLLIFGATNWDLIGRKEVPKQQAAYRNLGQNLWGPHRYGCLAGVRVRTVVSGSCAAHS 162
+G+LL FG +G K+ LG NL G G L G +V V G +
Sbjct: 615 RGRLLTFGCNKCGQLGVGNYKKR------LGINLLG----GPLGGKQVIRVSCGD--EFT 662
Query: 163 LLITTEGKLWSWGRNEKGQLG-------HGDTKRVEAPRLIEGLSHEVIVSAACGRNHTL 215
+ T + +++WG G+L HG PR I G H V +C HT+
Sbjct: 663 IAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFGSLHHV-PDLSCRGWHTI 721
Query: 216 ALTE 219
+ E
Sbjct: 722 LIVE 725
>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
Length = 692
Score = 90.9 bits (224), Expect = 3e-18
Identities = 102/405 (25%), Positives = 165/405 (40%), Gaps = 78/405 (19%)
Query: 35 KRERPERCSSSSGGGSSGDEDGLELDGAPGGGKRAARPATAGKA----GGAAVVITEPEH 90
+ R E+ + S GS + G P G R A P GG + P
Sbjct: 273 RMRRAEKSVAPSNTGSR--TTSVRCRGIPRGPVRPAIPPPLSSVYAWGGGLGTPLRLPML 330
Query: 91 TKERVKLEGSKCK-------GQLLIF-----GATNWDLI-GRKEVPKQQAAYRNL-GQNL 136
E V++ + + G+L+++ GA L+ G E P+ Q R L GQ+
Sbjct: 331 NTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLPGAVEQPQPQFISRFLEGQS- 389
Query: 137 WGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLI 196
GV ++ V G + +T G + ++G G LGHG + P ++
Sbjct: 390 ----------GVTIKHVACGDF--FTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIV 437
Query: 197 EGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQI-MYNGQP 255
E L +V ACG +H LAL+ +FA+G G+LGLG + ++ P Q+ M GQ
Sbjct: 438 EALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTR-ESHSCPQQVPMPPGQE 496
Query: 256 ITKMACGAEFSMIMDCKGNLYSFGCPEYGQLG--HNSDGKFIARAQRIEYDCEL------ 307
++ CG + SMI+ G + G + +LG H S G+ Q++E
Sbjct: 497 AQRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSA 556
Query: 308 -VPRRVAIFIE----------------------------KTKDGQILP-----VPNVVVR 333
+ + + I+ T+ G P + + +
Sbjct: 557 PLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMA 616
Query: 334 DVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKL 378
VACG T+ + ++ V+SWG G GRLG ++ D +PR V+L
Sbjct: 617 MVACGDAFTVAIGAESEVYSWGKGARGRLGRRDE-DAGLPRPVQL 660
Score = 38.5 bits (88), Expect = 0.015
Identities = 43/189 (22%), Positives = 80/189 (42%), Gaps = 19/189 (10%)
Query: 325 LPVPNVVVRDVACGANHTLVLDSQKRVFSW-----GFGGYGRLGHAEQKDEMVPRLVKLF 379
LP+ N V VA G + R+ W G GG L A ++ + P+ + F
Sbjct: 327 LPMLNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLPGAVEQPQ--PQFISRF 384
Query: 380 DFPGRGAS--QIYAGYTCSFAVSEVGGLFFWGATNT------SRESTMYPKAVQDLCGWR 431
G + + G + +++ G + +G+ + S P V+ L G+
Sbjct: 385 LEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYE 444
Query: 432 IRSLACGKSSIIVAADESTI-SWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVA 490
+ +ACG S ++ + E + +WG + G LG G +S + Q+V G +++V
Sbjct: 445 MVQVACGASHVLALSTERELFAWGRGDS-GRLGLGTR--ESHSCPQQVPMPPGQEAQRVV 501
Query: 491 MGYSHSLVI 499
G S+++
Sbjct: 502 CGIDSSMIL 510
>gi|6912330 deafness locus associated putative guanine nucleotide
exchange factor [Homo sapiens]
Length = 458
Score = 90.1 bits (222), Expect = 4e-18
Identities = 94/394 (23%), Positives = 154/394 (39%), Gaps = 72/394 (18%)
Query: 171 LWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAAC-GRNHTLALTETGSVFAFGEN 229
L++WG N GQLG G + V P+ + V G H+ +T+ G +F G N
Sbjct: 17 LFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLN 76
Query: 230 KMGQLGLGNQTDAVP--SPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLG 287
K GQLGLG+ T+ +P +P + ++ G PI ++ACG +F++++ G + S G +GQLG
Sbjct: 77 KDGQLGLGH-TEDIPYFTPCKSLF-GCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLG 134
Query: 288 HNSDGKFIARAQRIEYDCELV-----------------------------------PRRV 312
+ Q IE E V + +
Sbjct: 135 VPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQTL 194
Query: 313 AIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMV 372
+F + ++ + N V G++H+ L V+ WG +G+L + E V
Sbjct: 195 PLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLAN-EAAFLPV 253
Query: 373 PRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATN-------------------- 412
P+ ++ F + I++G+T A +E G +F WG +
Sbjct: 254 PQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQD 313
Query: 413 ----TSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGELGY-GDH 467
SR P + L G ++CG + SWG + E G GD
Sbjct: 314 SFLPCSRPPNSMPSSPHCLTG--ATEVSCGSEHNLAIIGGVCYSWG----WNEHGMCGDG 367
Query: 468 KPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIAR 501
+ A + V+ L V G HSL + +
Sbjct: 368 TEANVWAPKPVQALLSSSGLLVGCGAGHSLALCQ 401
Score = 44.7 bits (104), Expect = 2e-04
Identities = 35/126 (27%), Positives = 52/126 (41%), Gaps = 18/126 (14%)
Query: 104 GQLLIFGATNWDLIGRK-------EVPKQQA---AYRNLGQNLWGPHRYGCLAGVRVRTV 153
G++ +G ++ +GRK ++ KQ + R PH CL G
Sbjct: 284 GKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPH---CLTGA----- 335
Query: 154 VSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNH 213
SC + L G +SWG NE G G G V AP+ ++ L + CG H
Sbjct: 336 TEVSCGSEHNLAIIGGVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGH 395
Query: 214 TLALTE 219
+LAL +
Sbjct: 396 SLALCQ 401
>gi|63054860 RCC1 domain containing 1 [Homo sapiens]
Length = 376
Score = 89.4 bits (220), Expect = 7e-18
Identities = 64/229 (27%), Positives = 99/229 (43%), Gaps = 60/229 (26%)
Query: 159 AAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALT 218
A H+LL+ G+++SWG GQLGHG + PRL+E L V+ A G H++ ++
Sbjct: 167 AEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVS 226
Query: 219 ETGSVFAFGENKMGQLGL-----------------------------GNQTDAVPSPAQI 249
ETG ++ +G N+ GQL L G D P+P
Sbjct: 227 ETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIA 286
Query: 250 MY---------NGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQR 300
+ G K +CG+ + ++ G LY++G +YGQLGH D + R +R
Sbjct: 287 VQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGH-EDTTSLDRPRR 345
Query: 301 IEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQK 349
+EY F++K + V+ V CG +T V +K
Sbjct: 346 VEY-----------FVDK----------QLQVKAVTCGPWNTYVYAVEK 373
Score = 68.2 bits (165), Expect = 2e-11
Identities = 54/191 (28%), Positives = 83/191 (43%), Gaps = 28/191 (14%)
Query: 210 GRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIM 269
G H L L G VF++G + GQLG G + G + ++A G S+ +
Sbjct: 166 GAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCV 225
Query: 270 DCKGNLYSFGCPEYGQLGHNS-----DGKFIAR-AQRIEYDCELVPRRVAIFIEKTKDGQ 323
G++Y +G E GQL + DG+ +AR A + D V R +DG
Sbjct: 226 SETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGG-----AEDGA 280
Query: 324 ILPVPNVVVRD---------------VACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQK 368
P P + V+ +CG+ HT V+ +++WG+G YG+LGH +
Sbjct: 281 --PAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTT 338
Query: 369 DEMVPRLVKLF 379
PR V+ F
Sbjct: 339 SLDRPRRVEYF 349
Score = 63.9 bits (154), Expect = 3e-10
Identities = 32/82 (39%), Positives = 48/82 (58%), Gaps = 2/82 (2%)
Query: 328 PNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGAS 387
P + R + GA H L+LD+ +VFSWG G +G+LGH + E+ PRL++ G +
Sbjct: 156 PELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQ--GLVMA 213
Query: 388 QIYAGYTCSFAVSEVGGLFFWG 409
++ AG S VSE G ++ WG
Sbjct: 214 EVAAGGWHSVCVSETGDIYIWG 235
Score = 44.7 bits (104), Expect = 2e-04
Identities = 19/45 (42%), Positives = 30/45 (66%), Gaps = 1/45 (2%)
Query: 154 VSGSCAA-HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIE 197
V SC + H+ ++T G+L++WG + GQLGH DT ++ PR +E
Sbjct: 303 VKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVE 347
>gi|63054858 RCC1 domain containing 1 [Homo sapiens]
Length = 376
Score = 89.4 bits (220), Expect = 7e-18
Identities = 64/229 (27%), Positives = 99/229 (43%), Gaps = 60/229 (26%)
Query: 159 AAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALT 218
A H+LL+ G+++SWG GQLGHG + PRL+E L V+ A G H++ ++
Sbjct: 167 AEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVS 226
Query: 219 ETGSVFAFGENKMGQLGL-----------------------------GNQTDAVPSPAQI 249
ETG ++ +G N+ GQL L G D P+P
Sbjct: 227 ETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIA 286
Query: 250 MY---------NGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQR 300
+ G K +CG+ + ++ G LY++G +YGQLGH D + R +R
Sbjct: 287 VQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGH-EDTTSLDRPRR 345
Query: 301 IEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQK 349
+EY F++K + V+ V CG +T V +K
Sbjct: 346 VEY-----------FVDK----------QLQVKAVTCGPWNTYVYAVEK 373
Score = 68.2 bits (165), Expect = 2e-11
Identities = 54/191 (28%), Positives = 83/191 (43%), Gaps = 28/191 (14%)
Query: 210 GRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIM 269
G H L L G VF++G + GQLG G + G + ++A G S+ +
Sbjct: 166 GAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCV 225
Query: 270 DCKGNLYSFGCPEYGQLGHNS-----DGKFIAR-AQRIEYDCELVPRRVAIFIEKTKDGQ 323
G++Y +G E GQL + DG+ +AR A + D V R +DG
Sbjct: 226 SETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGG-----AEDGA 280
Query: 324 ILPVPNVVVRD---------------VACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQK 368
P P + V+ +CG+ HT V+ +++WG+G YG+LGH +
Sbjct: 281 --PAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTT 338
Query: 369 DEMVPRLVKLF 379
PR V+ F
Sbjct: 339 SLDRPRRVEYF 349
Score = 63.9 bits (154), Expect = 3e-10
Identities = 32/82 (39%), Positives = 48/82 (58%), Gaps = 2/82 (2%)
Query: 328 PNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGAS 387
P + R + GA H L+LD+ +VFSWG G +G+LGH + E+ PRL++ G +
Sbjct: 156 PELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQ--GLVMA 213
Query: 388 QIYAGYTCSFAVSEVGGLFFWG 409
++ AG S VSE G ++ WG
Sbjct: 214 EVAAGGWHSVCVSETGDIYIWG 235
Score = 44.7 bits (104), Expect = 2e-04
Identities = 19/45 (42%), Positives = 30/45 (66%), Gaps = 1/45 (2%)
Query: 154 VSGSCAA-HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIE 197
V SC + H+ ++T G+L++WG + GQLGH DT ++ PR +E
Sbjct: 303 VKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVE 347
>gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo
sapiens]
Length = 464
Score = 79.3 bits (194), Expect = 8e-15
Identities = 82/305 (26%), Positives = 125/305 (40%), Gaps = 50/305 (16%)
Query: 204 IVSAACGRNHTLALTETG---SVFAFGENKMGQLGL---------GNQTDAVPSPAQIMY 251
I SAACG TL ++T V+ G NK QLG G + PSP +
Sbjct: 109 ISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPL 168
Query: 252 NGQPITK---MACGAEFSMIMDCKGNLYSFGCPEYGQLGHN-SDGKFIARAQRIEYDCEL 307
+ T+ ++CG S+++ + ++S G YGQ G + + + + R+
Sbjct: 169 DRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRV------ 222
Query: 308 VPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQ 367
R+ F DGQ++ VACG +H+L L + V+S G+G G+ G
Sbjct: 223 --HRMQDF-----DGQVV--------QVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHY 267
Query: 368 KDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWG-------ATNTSRESTMY 420
P + D G Q+ C AVS GGLF WG A+ T
Sbjct: 268 NITSSPTKLG-GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNV 326
Query: 421 PKAVQDLCGWRIRSLACGKSSIIVAADESTI-SWGPSPTFGELGYGDHKPKSSTAAQEVK 479
P+ + ++R ACG + V E + WG +G LG G + +S+
Sbjct: 327 PRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG----YGILGKGPNLVESAVPEMIPP 382
Query: 480 TLDGI 484
TL G+
Sbjct: 383 TLFGL 387
Score = 75.1 bits (183), Expect = 1e-13
Identities = 73/292 (25%), Positives = 117/292 (40%), Gaps = 54/292 (18%)
Query: 170 KLWSWGRNEKGQLGHGDTKR--------------VEAPRLIEGLSHEVIVSAACGRNHTL 215
K+W G N+ QLG +++ V P ++ ++ +CGR H+L
Sbjct: 130 KVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLP--LDRPQETRVLQVSCGRAHSL 187
Query: 216 ALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQ----PITKMACGAEFSMIMDC 271
LT+ VF+ G N GQ G + + S + ++ Q + ++ACG + S+ +
Sbjct: 188 VLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTD 247
Query: 272 KGNLYSFGCPEYGQ--------------LGHNSDGKFIARAQRIEYDCELVPRRVAIF-- 315
KG +YS G GQ LG + G + + C V +F
Sbjct: 248 KGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGW 307
Query: 316 -------IEKTKDGQILPVPNVV-------VRDVACGANHTLVLDSQKRVFSWGFGGYGR 361
+ D + VP + VR ACG VL+ + VF WG+G G+
Sbjct: 308 GNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGK 367
Query: 362 ---LGHAEQKDEMVPRLVKLFDF-PGRGASQIYAGYTCSFAVSEVGGLFFWG 409
L + + + P L L +F P S+I G + A++ G LF WG
Sbjct: 368 GPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWG 419
Score = 68.2 bits (165), Expect = 2e-11
Identities = 64/267 (23%), Positives = 111/267 (41%), Gaps = 51/267 (19%)
Query: 153 VVSGSCA-AHSLLITTEGKLWSWGRNEKGQLG--------HGDTKRVEAPRLIEGLSHEV 203
V+ SC AHSL++T ++S G N GQ G + ++ RV + +G
Sbjct: 176 VLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ---- 231
Query: 204 IVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYN--GQPITKMAC 261
+V ACG++H+L LT+ G V++ G GQ GLG+ + SP ++ + G + ++A
Sbjct: 232 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHY-NITSSPTKLGGDLAGVNVIQVAT 290
Query: 262 GAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYD--------------CEL 307
+ + + G L+ +G EY QL +D + + + + C +
Sbjct: 291 YGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAV 350
Query: 308 VPRRVAIFI-------------EKTKDGQILPV--------PNVVVRDVACGANHTLVLD 346
+ +F+ E I P P + V + CG +H L
Sbjct: 351 LNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALT 410
Query: 347 SQKRVFSWGFGGYGRLGHAEQKDEMVP 373
++ +F WG G LG +D+ P
Sbjct: 411 NKGELFVWGKNIRGCLGIGRLEDQYFP 437
Score = 57.8 bits (138), Expect = 2e-08
Identities = 55/217 (25%), Positives = 99/217 (45%), Gaps = 27/217 (12%)
Query: 254 QPITKMACGAEFSMIMDCKGNL---YSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPR 310
Q I+ ACG F+++ ++ + G + QLG + K R Y+ L P
Sbjct: 107 QKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRG----YEYVLEPS 162
Query: 311 RVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDE 370
V++ +++ ++ ++L V+CG H+LVL ++ VFS G YG+ G ++E
Sbjct: 163 PVSLPLDRPQETRVL--------QVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENE 214
Query: 371 MVP---RLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFF--WGATNTS-----RESTMY 420
+ R+ ++ DF G+ Q+ G S +++ G ++ WGA + ++
Sbjct: 215 IYSESHRVHRMQDFDGQ-VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSP 273
Query: 421 PKAVQDLCGWRIRSLAC-GKSSIIVAADESTISWGPS 456
K DL G + +A G + V+AD WG S
Sbjct: 274 TKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNS 310
Score = 50.1 bits (118), Expect = 5e-06
Identities = 62/212 (29%), Positives = 90/212 (42%), Gaps = 39/212 (18%)
Query: 143 GCLAGVRVRTVVS-GSCAAHSLLITTEGKLWSWGRNEKGQLGH-GDTKRVEAPRLIEGLS 200
G LAGV V V + G C L ++ +G L+ WG +E QL D+ +V PR +
Sbjct: 278 GDLAGVNVIQVATYGDCC---LAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSG 334
Query: 201 HEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPS--PAQIM----YNGQ 254
+ AACG L G VF +G +G+ G AVP P + +N +
Sbjct: 335 VGKVRQAACGGTGCAVLNGEGHVFVWGYGILGK-GPNLVESAVPEMIPPTLFGLTEFNPE 393
Query: 255 -PITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVA 313
++++ CG + KG L+ +G G LG I R + + P RV
Sbjct: 394 IQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLG-------IGRLED-----QYFPWRV- 440
Query: 314 IFIEKTKDGQILPVPNVVVRDVACGANHTLVL 345
T G+ PV DVACG +H + L
Sbjct: 441 -----TMPGE--PV------DVACGVDHMVTL 459
>gi|57863304 inhibitor of Bruton's tyrosine kinase [Homo sapiens]
Length = 1353
Score = 79.3 bits (194), Expect = 8e-15
Identities = 79/290 (27%), Positives = 131/290 (45%), Gaps = 37/290 (12%)
Query: 146 AGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIV 205
+G+ ++ VV C HS+ ++ +G++++ G G+LGHGD + PRL+EGL+
Sbjct: 175 SGIYIKQVVL--CKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCS 232
Query: 206 SAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIM---YNGQPITKMACG 262
A ++HT+ LTE G V+ FG N QLG+ + P QI G+ I +A G
Sbjct: 233 QVAAAKDHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAG 292
Query: 263 AEFSMIMDCKGNLYSFGCPEYGQLG--HNSDGKFIARAQRIEYDCELVPRRVAIFIEKTK 320
F ++ + +Y+ G GQLG + +G+ A R L + +A+ +
Sbjct: 293 -RFHTVLWTREAVYTMGL-NGGQLGCLLDPNGEKCVTAPR--QVSALHHKDIALSLVAAS 348
Query: 321 DGQILPVPN----VVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLV 376
DG + V ++ D C + L+ +K + S GH E K + P +
Sbjct: 349 DGATVCVTTRGDIYLLADYQCKKMASKQLNLKKVLVSG--------GHMEYKVD--PEHL 398
Query: 377 KLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSREST--MYPKAV 424
K G +I C A+ G +F W + N+S + YP+ V
Sbjct: 399 K-----ENGGQKI-----CILAMDGAGRVFCWRSVNSSLKQCRWAYPRQV 438
Score = 54.3 bits (129), Expect = 3e-07
Identities = 49/196 (25%), Positives = 89/196 (45%), Gaps = 27/196 (13%)
Query: 171 LWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHE--VIVSAACGRNHTLALTETGSVFAFGE 228
+++WG N LGHG P L++ S I + H++ L++ G V+ G
Sbjct: 144 VYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGH 203
Query: 229 NKMGQLGLGN-QTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLG 287
G+LG G+ QT VP + + NG +++A + ++++ G +Y+FG + QLG
Sbjct: 204 GPGGRLGHGDEQTCLVPRLVEGL-NGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLG 262
Query: 288 HNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDS 347
++P + + + + L ++ VA G HT VL +
Sbjct: 263 -------------------IIPPPSSCNVPRQIQAKYLKGRTII--GVAAGRFHT-VLWT 300
Query: 348 QKRVFSWGFGGYGRLG 363
++ V++ G G G+LG
Sbjct: 301 REAVYTMGLNG-GQLG 315
Score = 40.0 bits (92), Expect = 0.005
Identities = 38/159 (23%), Positives = 63/159 (39%), Gaps = 7/159 (4%)
Query: 351 VFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGA 410
V++WG LGH Q + P LV LF G Q+ S +S+ G ++ G
Sbjct: 144 VYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGH 203
Query: 411 TNTSR------ESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGELGY 464
R ++ + P+ V+ L G +A K +V ++ + F +LG
Sbjct: 204 GPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGI 263
Query: 465 GDHKPKSSTAAQ-EVKTLDGIFSEQVAMGYSHSLVIARD 502
+ Q + K L G VA G H+++ R+
Sbjct: 264 IPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTRE 302
>gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo
sapiens]
Length = 596
Score = 76.6 bits (187), Expect = 5e-14
Identities = 43/112 (38%), Positives = 65/112 (58%), Gaps = 3/112 (2%)
Query: 158 CAAHSLL-ITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLA 216
C A LL +T G +W+WG+ + +LGH V P+++EGL + IV A G H LA
Sbjct: 63 CGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLA 122
Query: 217 LTETGSVFAFGENKMGQLGLGNQT-DAVPSPAQIMYNGQPITKMACGAEFSM 267
+ ++G V+A+G+N GQ G G T + P+ Q + GQ I +ACG+ S+
Sbjct: 123 VMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGL-EGQKIMCVACGSSHSV 173
Score = 63.2 bits (152), Expect = 6e-10
Identities = 37/125 (29%), Positives = 68/125 (54%), Gaps = 4/125 (3%)
Query: 168 EGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFG 227
E ++SWG + G+LG G ++ P+ IE L+ + + CG LALT++G V+ +G
Sbjct: 22 ESLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWG 81
Query: 228 ENKMGQLGLGNQTDAVPSPAQIM--YNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQ 285
K LG+++D Q++ G+ I +A GA+ + + G +Y++G ++GQ
Sbjct: 82 --KGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQ 139
Query: 286 LGHNS 290
G+ +
Sbjct: 140 QGNGT 144
Score = 58.2 bits (139), Expect = 2e-08
Identities = 67/284 (23%), Positives = 123/284 (43%), Gaps = 50/284 (17%)
Query: 223 VFAFGENKMGQLGLGNQTDA-VPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCP 281
VF++G+ G+LG G +P + + NGQ + ++ CGA+F + + G ++++G
Sbjct: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERL-NGQGVCQIECGAQFLLALTKSGVVWTWGKG 83
Query: 282 EYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANH 341
+Y +LGH SD V R +E + +I+ VA GA H
Sbjct: 84 DYFRLGHRSD----------------VHVRKPQVVEGLRGKKIV--------HVAVGAQH 119
Query: 342 TLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSE 401
L + +V++WG +G+ G+ P LV+ G+ + G + S A +
Sbjct: 120 CLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQ--GLEGQKIMCVACGSSHSVAWTT 177
Query: 402 VGGLFFWGATNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGE 461
V AT + E ++ A L G S + V +D ++ + +
Sbjct: 178 VD-----VATPSVHEPVLFQTARDPL----------GASYLGVPSDVNSSAASNKIS--- 219
Query: 462 LGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGY---SHSLVIARD 502
G + KP + A+ + +LDG ++Q A+ + + ++ ARD
Sbjct: 220 -GASNSKPYHPSLAKILLSLDGNLAKQQALSHILTALQIMYARD 262
Score = 58.2 bits (139), Expect = 2e-08
Identities = 41/139 (29%), Positives = 68/139 (48%), Gaps = 10/139 (7%)
Query: 147 GVRVRTVVSGSCAA-HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIV 205
G+R + +V + A H L + G++++WG N+ GQ G+G T P L++GL + I+
Sbjct: 104 GLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKIM 163
Query: 206 SAACGRNHTLALT----ETGSV-----FAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPI 256
ACG +H++A T T SV F + +G LG +D S A +G
Sbjct: 164 CVACGSSHSVAWTTVDVATPSVHEPVLFQTARDPLGASYLGVPSDVNSSAASNKISGASN 223
Query: 257 TKMACGAEFSMIMDCKGNL 275
+K + +++ GNL
Sbjct: 224 SKPYHPSLAKILLSLDGNL 242
>gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo
sapiens]
Length = 1052
Score = 75.9 bits (185), Expect = 9e-14
Identities = 43/112 (38%), Positives = 64/112 (57%), Gaps = 3/112 (2%)
Query: 158 CAAHSLL-ITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLA 216
C A LL +T G +W+WG+ + +LGH V P+++EGL + IV A G H LA
Sbjct: 715 CGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLA 774
Query: 217 LTETGSVFAFGENKMGQLGLGNQT-DAVPSPAQIMYNGQPITKMACGAEFSM 267
+ ++G V+A+G+N GQ G G T + P Q + GQ I +ACG+ S+
Sbjct: 775 VMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQGL-EGQKIMCVACGSSHSV 825
Score = 63.5 bits (153), Expect = 4e-10
Identities = 37/124 (29%), Positives = 68/124 (54%), Gaps = 4/124 (3%)
Query: 169 GKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGE 228
G ++SWG + G+LG G ++ P+ IE L+ + + CG LALT++G V+ +G
Sbjct: 675 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWG- 733
Query: 229 NKMGQLGLGNQTDAVPSPAQIM--YNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQL 286
K LG+++D Q++ G+ I +A GA+ + + G +Y++G ++GQ
Sbjct: 734 -KGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQ 792
Query: 287 GHNS 290
G+ +
Sbjct: 793 GNGT 796
Score = 58.5 bits (140), Expect = 1e-08
Identities = 67/286 (23%), Positives = 118/286 (41%), Gaps = 50/286 (17%)
Query: 221 GSVFAFGENKMGQLGLGNQTDA-VPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFG 279
G VF++G+ G+LG G +P + + NGQ + ++ CGA+F + + G ++++G
Sbjct: 675 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERL-NGQGVCQIECGAQFLLALTKSGVVWTWG 733
Query: 280 CPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGA 339
+Y +LGH SD V R +E + +I+ VA GA
Sbjct: 734 KGDYFRLGHRSD----------------VHVRKPQVVEGLRGKKIV--------HVAVGA 769
Query: 340 NHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAV 399
H L + +V++WG +G+ G+ P LV+ G+ + G + S A
Sbjct: 770 QHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQ--GLEGQKIMCVACGSSHSVA- 826
Query: 400 SEVGGLFFWGATNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTF 459
W + + S P Q S S + +A + IS
Sbjct: 827 --------WTTMDVATPSVHEPVLFQTARDPLGASYLGVPSDVNSSAASNKIS------- 871
Query: 460 GELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGY---SHSLVIARD 502
G + KP + A+ + +LDG ++Q A+ + + ++ ARD
Sbjct: 872 ---GASNSKPYHPSLAKILLSLDGNLAKQQALSHILTALQIMYARD 914
Score = 58.2 bits (139), Expect = 2e-08
Identities = 41/139 (29%), Positives = 68/139 (48%), Gaps = 10/139 (7%)
Query: 147 GVRVRTVVSGSCAA-HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIV 205
G+R + +V + A H L + G++++WG N+ GQ G+G T P L++GL + I+
Sbjct: 756 GLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQGLEGQKIM 815
Query: 206 SAACGRNHTLALT----ETGSV-----FAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPI 256
ACG +H++A T T SV F + +G LG +D S A +G
Sbjct: 816 CVACGSSHSVAWTTMDVATPSVHEPVLFQTARDPLGASYLGVPSDVNSSAASNKISGASN 875
Query: 257 TKMACGAEFSMIMDCKGNL 275
+K + +++ GNL
Sbjct: 876 SKPYHPSLAKILLSLDGNL 894
>gi|40316935 alsin isoform 1 [Homo sapiens]
Length = 1657
Score = 72.4 bits (176), Expect = 9e-13
Identities = 46/141 (32%), Positives = 75/141 (53%), Gaps = 8/141 (5%)
Query: 146 AGVRVRTVV---SGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHE 202
A V+ RTVV + S A +LL + ++W+WG+ ++GQLGHGD P ++ L +
Sbjct: 500 ARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGK 559
Query: 203 VIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACG 262
++ G H+LALT V+++G N GQLG + VP A+I + + +A G
Sbjct: 560 EVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDFPTTVPRLAKIS-SENGVWSIAAG 618
Query: 263 AEFSMIM----DCKGNLYSFG 279
++S+ + D + LY G
Sbjct: 619 RDYSLFLVDTEDFQPGLYYSG 639
Score = 53.5 bits (127), Expect = 5e-07
Identities = 39/156 (25%), Positives = 71/156 (45%), Gaps = 17/156 (10%)
Query: 185 GDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGS-------------VFAFGENKM 231
G ++R+ P L+ +S ++ AA + T+ LT T S V+ +G+ K
Sbjct: 477 GGSRRLSLPGLLSQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKE 536
Query: 232 GQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSD 291
GQLG G+ + +G+ + + G S+ + K +YS+G +GQLGH+
Sbjct: 537 GQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDF 596
Query: 292 GKFIARAQRIEYDCEL----VPRRVAIFIEKTKDGQ 323
+ R +I + + R ++F+ T+D Q
Sbjct: 597 PTTVPRLAKISSENGVWSIAAGRDYSLFLVDTEDFQ 632
Score = 52.8 bits (125), Expect = 8e-07
Identities = 51/214 (23%), Positives = 93/214 (43%), Gaps = 45/214 (21%)
Query: 145 LAGVRVRTVVSGSCAA-HSLLITTEGKLWSWG----RNEKGQLGHGDTKRVEAPRLIEGL 199
L G +TV+ + H +L+T +G+++S+G R+ ++ +P L L
Sbjct: 35 LPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPS------SPILENAL 88
Query: 200 SHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQP---- 255
+ +++ A G H+ A+T+ G + +GEN GQ + NQ VP P +
Sbjct: 89 VGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQ-QYVPEPNPVSIADSEASPL 147
Query: 256 ----ITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRR 311
I ++ACG E ++ + ++++G QLG + + + Q++E+
Sbjct: 148 LAVRILQLACGEEHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEH-------- 197
Query: 312 VAIFIEKTKDGQILPVPNVVVRDVACGANHTLVL 345
+ VV VACGA H+L L
Sbjct: 198 ---------------LAGRVVLQVACGAFHSLAL 216
Score = 50.4 bits (119), Expect = 4e-06
Identities = 46/168 (27%), Positives = 72/168 (42%), Gaps = 25/168 (14%)
Query: 193 PRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYN 252
P + G + ++ AA G H + LTE G V++FG + PS + I+ N
Sbjct: 32 PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRS----GPVEICPS-SPILEN 86
Query: 253 ---GQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVP 309
GQ + +A G+ S + G Y +G NS G+ Q +Y E P
Sbjct: 87 ALVGQYVITVATGSFHSGAVTDNGVAYMWG--------ENSAGQCAVANQ--QYVPEPNP 136
Query: 310 RRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFG 357
+A D + P+ V + +ACG HTL L + +++WG G
Sbjct: 137 VSIA-------DSEASPLLAVRILQLACGEEHTLALSISREIWAWGTG 177
Score = 41.6 bits (96), Expect = 0.002
Identities = 31/123 (25%), Positives = 58/123 (47%), Gaps = 25/123 (20%)
Query: 256 ITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIF 315
+T G +++ + ++++G + GQLGH +++PR +
Sbjct: 509 LTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHG----------------DVLPRLQPLC 552
Query: 316 IEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRL 375
+ K DG+ V + G H+L L ++ +V+SWG +G+LGH++ VPRL
Sbjct: 553 V-KCLDGK-------EVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSD-FPTTVPRL 603
Query: 376 VKL 378
K+
Sbjct: 604 AKI 606
Score = 39.7 bits (91), Expect = 0.007
Identities = 25/76 (32%), Positives = 40/76 (52%), Gaps = 5/76 (6%)
Query: 145 LAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTK-RVEAPRLIEGLSHEV 203
L VR+ + G H+L ++ ++W+WG QLG T V P+ +E L+ V
Sbjct: 147 LLAVRILQLACGE--EHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEHLAGRV 202
Query: 204 IVSAACGRNHTLALTE 219
++ ACG H+LAL +
Sbjct: 203 VLQVACGAFHSLALVQ 218
Score = 38.5 bits (88), Expect = 0.015
Identities = 40/173 (23%), Positives = 61/173 (35%), Gaps = 49/173 (28%)
Query: 330 VVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQI 389
VV+ G L+ + V++WG G G+LGH + + P VK D G+ +
Sbjct: 507 VVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLD--GKEVIHL 564
Query: 390 YAGYTCSFAVSEVGGLFFWGATNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADES 449
AG G S+ + A
Sbjct: 565 EAG---------------------------------------------GYHSLALTAKSQ 579
Query: 450 TISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARD 502
SWG S TFG+LG+ D P + ++ + +G++S YS LV D
Sbjct: 580 VYSWG-SNTFGQLGHSDF-PTTVPRLAKISSENGVWSIAAGRDYSLFLVDTED 630
Score = 32.0 bits (71), Expect = 1.4
Identities = 49/200 (24%), Positives = 77/200 (38%), Gaps = 27/200 (13%)
Query: 332 VRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFD-FPGRGASQIY 390
V A G H ++L V+S +G L E+ P L + G+ +
Sbjct: 43 VLQAALGVKHGVLLTEDGEVYS-----FGTLPWRSGPVEICPSSPILENALVGQYVITVA 97
Query: 391 AGYTCSFAVSEVGGLFFWGATNTSR---ESTMY-----PKAVQD-----LCGWRIRSLAC 437
G S AV++ G + WG + + + Y P ++ D L RI LAC
Sbjct: 98 TGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLAC 157
Query: 438 GKSSIIVAADESTI-SWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHS 496
G+ + + I +WG G + T Q+V+ L G QVA G HS
Sbjct: 158 GEEHTLALSISREIWAWGTGCQLGLITTAF----PVTKPQKVEHLAGRVVLQVACGAFHS 213
Query: 497 LVIARDESETEKEKIKKLPE 516
L + + + +K +PE
Sbjct: 214 LALVQC---LPSQDLKPVPE 230
>gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo
sapiens]
Length = 1102
Score = 72.0 bits (175), Expect = 1e-12
Identities = 42/112 (37%), Positives = 63/112 (56%), Gaps = 3/112 (2%)
Query: 158 CAAHSLL-ITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLA 216
C A LL +T G +W+WG+ + +LGH V +++EGL + IV A G H LA
Sbjct: 765 CGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLA 824
Query: 217 LTETGSVFAFGENKMGQLGLGNQT-DAVPSPAQIMYNGQPITKMACGAEFSM 267
+ ++G V+A+G+N GQ G G T + P Q + GQ I +ACG+ S+
Sbjct: 825 VMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQGL-EGQKIMCVACGSSHSV 875
Score = 63.5 bits (153), Expect = 4e-10
Identities = 37/124 (29%), Positives = 68/124 (54%), Gaps = 4/124 (3%)
Query: 169 GKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGE 228
G ++SWG + G+LG G ++ P+ IE L+ + + CG LALT++G V+ +G
Sbjct: 725 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWG- 783
Query: 229 NKMGQLGLGNQTDAVPSPAQIM--YNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQL 286
K LG+++D Q++ G+ I +A GA+ + + G +Y++G ++GQ
Sbjct: 784 -KGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQ 842
Query: 287 GHNS 290
G+ +
Sbjct: 843 GNGT 846
Score = 58.5 bits (140), Expect = 1e-08
Identities = 67/286 (23%), Positives = 118/286 (41%), Gaps = 50/286 (17%)
Query: 221 GSVFAFGENKMGQLGLGNQTDA-VPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFG 279
G VF++G+ G+LG G +P + + NGQ + ++ CGA+F + + G ++++G
Sbjct: 725 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERL-NGQGVCQIECGAQFLLALTKSGVVWTWG 783
Query: 280 CPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGA 339
+Y +LGH SD V R +E + +I+ VA GA
Sbjct: 784 KGDYFRLGHRSD----------------VHVRKLQVVEGLRGKKIV--------HVAVGA 819
Query: 340 NHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAV 399
H L + +V++WG +G+ G+ P LV+ G+ + G + S A
Sbjct: 820 QHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQ--GLEGQKIMCVACGSSHSVA- 876
Query: 400 SEVGGLFFWGATNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTF 459
W + + S P Q S S + +A + IS
Sbjct: 877 --------WTTMDVATPSVHEPVLFQTARDPLGASYLGVPSDVNSSAASNKIS------- 921
Query: 460 GELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGY---SHSLVIARD 502
G + KP + A+ + +LDG ++Q A+ + + ++ ARD
Sbjct: 922 ---GASNSKPYHPSLAKILLSLDGNLAKQQALSHILTALQIMYARD 964
Score = 58.2 bits (139), Expect = 2e-08
Identities = 41/139 (29%), Positives = 68/139 (48%), Gaps = 10/139 (7%)
Query: 147 GVRVRTVVSGSCAA-HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIV 205
G+R + +V + A H L + G++++WG N+ GQ G+G T P L++GL + I+
Sbjct: 806 GLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQGLEGQKIM 865
Query: 206 SAACGRNHTLALT----ETGSV-----FAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPI 256
ACG +H++A T T SV F + +G LG +D S A +G
Sbjct: 866 CVACGSSHSVAWTTMDVATPSVHEPVLFQTARDPLGASYLGVPSDVNSSAASNKISGASN 925
Query: 257 TKMACGAEFSMIMDCKGNL 275
+K + +++ GNL
Sbjct: 926 SKPYHPSLAKILLSLDGNL 944
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.134 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,972,699
Number of Sequences: 37866
Number of extensions: 1078622
Number of successful extensions: 5900
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 63
Number of HSP's successfully gapped in prelim test: 145
Number of HSP's that attempted gapping in prelim test: 4772
Number of HSP's gapped (non-prelim): 743
length of query: 522
length of database: 18,247,518
effective HSP length: 107
effective length of query: 415
effective length of database: 14,195,856
effective search space: 5891280240
effective search space used: 5891280240
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.