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Search of human proteins with 28557796
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|28557796 low density lipoprotein receptor class A domain
containing 3 [Homo sapiens]
(345 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|28557796 low density lipoprotein receptor class A domain cont... 729 0.0
gi|126012573 low density lipoprotein-related protein 2 [Homo sap... 121 8e-28
gi|61744467 low density lipoprotein receptor-related protein 8 i... 119 5e-27
gi|61744471 low density lipoprotein receptor-related protein 8 i... 117 2e-26
gi|65301119 low density lipoprotein receptor-related protein 8 i... 117 2e-26
gi|66082554 low density lipoprotein receptor-related protein 8 i... 116 3e-26
gi|126012562 low density lipoprotein-related protein 1 [Homo sap... 115 7e-26
gi|157384998 low density lipoprotein receptor-related protein 4 ... 115 7e-26
gi|93102379 low density lipoprotein-related protein 1B precursor... 112 5e-25
gi|148727288 low density lipoprotein receptor-related protein 6 ... 110 1e-24
gi|65301164 very low density lipoprotein receptor isoform b [Hom... 108 5e-24
gi|65301167 very low density lipoprotein receptor isoform a [Hom... 108 5e-24
gi|119709832 low density lipoprotein receptor-related protein 5 ... 108 7e-24
gi|4507157 sortilin-related receptor containing LDLR class A rep... 106 3e-23
gi|29244926 corin [Homo sapiens] 106 3e-23
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 103 2e-22
gi|222831592 transmembrane protease, serine 7 [Homo sapiens] 101 9e-22
gi|11415040 matriptase [Homo sapiens] 100 2e-21
gi|4504975 low density lipoprotein receptor precursor [Homo sapi... 99 4e-21
gi|134031945 SCO-spondin [Homo sapiens] 96 5e-20
gi|167555125 low density lipoprotein receptor-related protein 3 ... 91 2e-18
gi|208973262 low density lipoprotein-related protein 12 isoform ... 90 3e-18
gi|7305525 low density lipoprotein-related protein 12 isoform a ... 90 3e-18
gi|32490559 low density lipoprotein receptor-related protein 10 ... 87 3e-17
gi|23957702 transmembrane protease, serine 6 [Homo sapiens] 86 4e-17
gi|7706111 8D6 antigen [Homo sapiens] 73 4e-13
gi|239755250 PREDICTED: chromosome 10 open reading frame 112 [Ho... 72 6e-13
gi|239749752 PREDICTED: chromosome 10 open reading frame 112 [Ho... 72 6e-13
gi|239744011 PREDICTED: chromosome 10 open reading frame 112 [Ho... 70 2e-12
gi|119392081 complement factor I preproprotein [Homo sapiens] 60 3e-09
>gi|28557796 low density lipoprotein receptor class A domain
containing 3 [Homo sapiens]
Length = 345
Score = 729 bits (1881), Expect = 0.0
Identities = 345/345 (100%), Positives = 345/345 (100%)
Query: 1 MWLLGPLCLLLSSAAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSD 60
MWLLGPLCLLLSSAAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSD
Sbjct: 1 MWLLGPLCLLLSSAAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSD 60
Query: 61 EKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHC 120
EKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHC
Sbjct: 61 EKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHC 120
Query: 121 KNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQVFVTSENQLVYYPSITYAIIGSS 180
KNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQVFVTSENQLVYYPSITYAIIGSS
Sbjct: 121 KNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQVFVTSENQLVYYPSITYAIIGSS 180
Query: 181 VIFVLVVALLALVLHHQRKRNNLMTLPVHRLQHPVLLSRLVVLDHPHHCNVTYNVNNGIQ 240
VIFVLVVALLALVLHHQRKRNNLMTLPVHRLQHPVLLSRLVVLDHPHHCNVTYNVNNGIQ
Sbjct: 181 VIFVLVVALLALVLHHQRKRNNLMTLPVHRLQHPVLLSRLVVLDHPHHCNVTYNVNNGIQ 240
Query: 241 YVASQAEQNASEVGSPPSYSEALLDQRPAWYDLPPPPYSSDTESLNQADLPPYRSRSGSA 300
YVASQAEQNASEVGSPPSYSEALLDQRPAWYDLPPPPYSSDTESLNQADLPPYRSRSGSA
Sbjct: 241 YVASQAEQNASEVGSPPSYSEALLDQRPAWYDLPPPPYSSDTESLNQADLPPYRSRSGSA 300
Query: 301 NSASSQAASSLLSVEDTSHSPGQPGPQEGTAEPRDSEPSQGTEEV 345
NSASSQAASSLLSVEDTSHSPGQPGPQEGTAEPRDSEPSQGTEEV
Sbjct: 301 NSASSQAASSLLSVEDTSHSPGQPGPQEGTAEPRDSEPSQGTEEV 345
>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
Length = 4655
Score = 121 bits (304), Expect = 8e-28
Identities = 55/127 (43%), Positives = 75/127 (59%), Gaps = 3/127 (2%)
Query: 26 TNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCI 85
T +C + +F C NGRC+P + CDG+ DC D SDE+ C + C + F C G CI
Sbjct: 1023 TEQCGL-FSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHG-ECI 1080
Query: 86 IGRFRCNGFEDCPDGSDEENC-TANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDE 144
+RC+ DC DGSDE NC T P C +Y C N CI K+++CD N+C D SDE
Sbjct: 1081 PAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDE 1140
Query: 145 ESCESSQ 151
++C S++
Sbjct: 1141 KNCNSTE 1147
Score = 112 bits (280), Expect = 5e-25
Identities = 58/122 (47%), Positives = 71/122 (58%), Gaps = 10/122 (8%)
Query: 32 PGNFMCSNGRCIPGAWQCDGLPDCFDKSDE--KECPKAKSKCGP-TFFPCASGIHCIIGR 88
PG F C+NGRCIP AW+CD DC D SDE +EC + C T F C + CI
Sbjct: 3637 PGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKW 3696
Query: 89 FRCNGFEDCPDGSDEENC---TANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEE 145
CNG +DC D SDE+ C T +P+ + CKN CI + CDGQN+C DNSDEE
Sbjct: 3697 AVCNGVDDCRDNSDEQGCEERTCHPV----GDFRCKNHHCIPLRWQCDGQNDCGDNSDEE 3752
Query: 146 SC 147
+C
Sbjct: 3753 NC 3754
Score = 107 bits (267), Expect = 2e-23
Identities = 50/114 (43%), Positives = 65/114 (57%), Gaps = 3/114 (2%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPK-AKSKCGPTFFPCASGIHCIIGRFRCNG 93
F C +G CIP W+CD DC D SDE CP A + C T + C + CI + C+
Sbjct: 1072 FTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNH-QCISKNWVCDT 1130
Query: 94 FEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESC 147
DC DGSDE+NC + C ++++C N CID SF+CDG +C D SDE C
Sbjct: 1131 DNDCGDGSDEKNCNSTET-CQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGC 1183
Score = 105 bits (263), Expect = 5e-23
Identities = 55/146 (37%), Positives = 72/146 (49%), Gaps = 11/146 (7%)
Query: 8 CLLLSSAAESQLLPGNNFTNECNIP-----GNFMCSNGRCIPGAWQCDGLPDCFDKSDEK 62
C+ L + Q G+N E P F C N +CIP W CD DC D SDE+
Sbjct: 3732 CIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDER 3791
Query: 63 ECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTA---NPLLCSTARYH 119
+C C P +F C SG HC+ +C+G DC D SDE +C + C +
Sbjct: 3792 DCEMRT--CHPEYFQCTSG-HCVHSELKCDGSADCLDASDEADCPTRFPDGAYCQATMFE 3848
Query: 120 CKNGLCIDKSFICDGQNNCQDNSDEE 145
CKN +CI + CDG ++C D SDEE
Sbjct: 3849 CKNHVCIPPYWKCDGDDDCGDGSDEE 3874
Score = 100 bits (249), Expect = 2e-21
Identities = 52/118 (44%), Positives = 68/118 (57%), Gaps = 5/118 (4%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGF 94
+ C+N RCIP +WQCD DC D SDE A C P F CA+G CI ++C+
Sbjct: 3599 WQCANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANG-RCIPQAWKCDVD 3657
Query: 95 EDCPDGSDE--ENCTANPLLCST-ARYHCK-NGLCIDKSFICDGQNNCQDNSDEESCE 148
DC D SDE E C ++ LC + CK N CI K +C+G ++C+DNSDE+ CE
Sbjct: 3658 NDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCE 3715
Score = 100 bits (249), Expect = 2e-21
Identities = 49/127 (38%), Positives = 65/127 (51%), Gaps = 5/127 (3%)
Query: 29 CNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGR 88
C+ G+F C N CIP WQCDG DC D SDE+ C A +C + F C + CI R
Sbjct: 3719 CHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENC--APRECTESEFRCVNQ-QCIPSR 3775
Query: 89 FRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCE 148
+ C+ + DC D SDE +C C + C +G C+ CDG +C D SDE C
Sbjct: 3776 WICDHYNDCGDNSDERDCEMR--TCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCP 3833
Query: 149 SSQEPGS 155
+ G+
Sbjct: 3834 TRFPDGA 3840
Score = 98.2 bits (243), Expect = 9e-21
Identities = 48/122 (39%), Positives = 67/122 (54%), Gaps = 6/122 (4%)
Query: 28 ECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIG 87
EC+ +F C +G CIP W+CDG DC D +DE C A C +F C S CI
Sbjct: 27 ECD-SAHFRCGSGHCIPADWRCDGTKDCSDDADEIGC--AVVTCQQGYFKCQSEGQCIPN 83
Query: 88 RFRCNGFEDCPDGSDE-ENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEES 146
+ C+ +DC DGSDE ++C+ + CS+ + C NG CI + CD +C D +DE
Sbjct: 84 SWVCDQDQDCDDGSDERQDCSQS--TCSSHQITCSNGQCIPSEYRCDHVRDCPDGADEND 141
Query: 147 CE 148
C+
Sbjct: 142 CQ 143
Score = 96.3 bits (238), Expect = 4e-20
Identities = 48/114 (42%), Positives = 67/114 (58%), Gaps = 5/114 (4%)
Query: 35 FMCSNG-RCIPGAWQCDGLPDCFDKSDEKE-CPKAKSKCGPTFFPCASGIHCIIGRFRCN 92
F+C+N +CIP W+CDG DC D SDE CP+ + G F C+ G +C + CN
Sbjct: 3517 FLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQ--FQCSDG-NCTSPQTLCN 3573
Query: 93 GFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEES 146
++CPDGSDE+ C + + C N CI +S+ CD N+C+DNSDE+S
Sbjct: 3574 AHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQCDTFNDCEDNSDEDS 3627
Score = 95.1 bits (235), Expect = 8e-20
Identities = 47/115 (40%), Positives = 64/115 (55%), Gaps = 3/115 (2%)
Query: 35 FMCSNG-RCIPGAWQCDGLPDCFDKSDEKECP-KAKSKCGPTFFPCASGIHCIIGRFRCN 92
F C++G +CI +CDG+ DC D SDE CP + C F C CI + C+
Sbjct: 1192 FKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECD 1251
Query: 93 GFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESC 147
G DC GSDE N P C ++ +HC NG CI ++++CD N+C D SDE+ C
Sbjct: 1252 GHPDCLYGSDEHNACV-PKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDC 1305
Score = 94.7 bits (234), Expect = 1e-19
Identities = 49/127 (38%), Positives = 68/127 (53%), Gaps = 5/127 (3%)
Query: 28 ECNIPGNFMCSNGRCIPGAWQCDGLPDCFDK--SDEKECPKAKSKCGPTFFPCASGIHCI 85
+CN FMC+N RCIP + C+G+ +C D SDEK CP + G T C + CI
Sbjct: 2779 DCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDRTCQSGYT--KCHNSNICI 2836
Query: 86 IGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDE- 144
+ C+G DC D SDE CS++ + C +G CI + + CD + +C D SDE
Sbjct: 2837 PRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASDEP 2896
Query: 145 ESCESSQ 151
SC S+
Sbjct: 2897 ASCGHSE 2903
Score = 94.4 bits (233), Expect = 1e-19
Identities = 48/125 (38%), Positives = 67/125 (53%), Gaps = 8/125 (6%)
Query: 27 NECNIPG--NFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHC 84
N+C P C NG C + +CD DC D SDE C + C F C +G C
Sbjct: 140 NDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCTEI---CLHNEFSCGNG-EC 195
Query: 85 IIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDE 144
I + C+ DC DGSDE C N C ++ C +G CI ++++CDG+++C+DN DE
Sbjct: 196 IPRAYVCDHDNDCQDGSDEHAC--NYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDE 253
Query: 145 ESCES 149
+ CES
Sbjct: 254 DGCES 258
Score = 93.6 bits (231), Expect = 2e-19
Identities = 51/119 (42%), Positives = 63/119 (52%), Gaps = 8/119 (6%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSK-CGPTFFPCASGI----HCIIGRF 89
F C GRCIP W CDG DC D SDE + + +++ C + F C + CI +
Sbjct: 2911 FKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSW 2970
Query: 90 RCNGFEDCPDGSDE-ENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESC 147
C+G DC DG DE +NCT CS + C GLCI K F CD N+C D SDE C
Sbjct: 2971 VCDGDVDCTDGYDENQNCTRRT--CSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGC 3027
Score = 92.0 bits (227), Expect = 7e-19
Identities = 52/125 (41%), Positives = 65/125 (52%), Gaps = 6/125 (4%)
Query: 24 NFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIH 83
N T C P F C N RCI ++ CDG DC D SDE C C + F CASG
Sbjct: 1144 NSTETCQ-PSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVL---NCTASQFKCASGDK 1199
Query: 84 CIIGRFRCNGFEDCPDGSDEENC-TANPLLCSTARYHC-KNGLCIDKSFICDGQNNCQDN 141
CI RC+G DC D SDE C T P +C + + C ++G+CI + CDG +C
Sbjct: 1200 CIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYG 1259
Query: 142 SDEES 146
SDE +
Sbjct: 1260 SDEHN 1264
Score = 92.0 bits (227), Expect = 7e-19
Identities = 49/116 (42%), Positives = 61/116 (52%), Gaps = 11/116 (9%)
Query: 35 FMCSNGR-----CIPGAWQCDGLPDCFDKSDEKE-CPKAKSKCGPTFFPCASGIHCIIGR 88
F+C N R CIP +W CDG DC D DE + C + C F C G+ CI
Sbjct: 2953 FLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNC--TRRTCSENEFTCGYGL-CIPKI 3009
Query: 89 FRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDE 144
FRC+ DC D SDE C C ++ C+NG CI K+F+CD N+C D SDE
Sbjct: 3010 FRCDRHNDCGDYSDERGCLYQT--CQQNQFTCQNGRCISKTFVCDEDNDCGDGSDE 3063
Score = 89.4 bits (220), Expect = 4e-18
Identities = 50/122 (40%), Positives = 61/122 (50%), Gaps = 5/122 (4%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCG-PTFFPCASGIHCIIGRFRCNG 93
F C N CIP W+CDG DC D SDE+ C P F C + CI CNG
Sbjct: 3847 FECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNN-RCIYSHEVCNG 3905
Query: 94 FEDCPDGSDE--ENCTA-NPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESS 150
+DC DG+DE E+C P C+ Y C NG CI +CD ++C D SDE C
Sbjct: 3906 VDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGCNKG 3965
Query: 151 QE 152
+E
Sbjct: 3966 KE 3967
Score = 87.4 bits (215), Expect = 2e-17
Identities = 52/137 (37%), Positives = 64/137 (46%), Gaps = 9/137 (6%)
Query: 23 NNFTNECNIP------GNFMCSNGR-CIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTF 75
NN ++E N P G C N CIP + CDG DC D SDE C +
Sbjct: 2809 NNTSDEKNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSE 2868
Query: 76 FPCASGIHCIIGRFRCNGFEDCPDGSDEE-NCTANPLLCSTARYHCKNGLCIDKSFICDG 134
F CASG CI + C+ DC D SDE +C + C + C G CI +ICDG
Sbjct: 2869 FQCASG-RCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDG 2927
Query: 135 QNNCQDNSDEESCESSQ 151
N+C D SDE+ Q
Sbjct: 2928 DNDCGDMSDEDKRHQCQ 2944
Score = 85.5 bits (210), Expect = 6e-17
Identities = 42/112 (37%), Positives = 64/112 (57%), Gaps = 4/112 (3%)
Query: 35 FMCS-NGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNG 93
F C +G CIP W+CDG PDC SDE K+ C ++F C +G +CI + C+
Sbjct: 1235 FQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKT-CPSSYFHCDNG-NCIHRAWLCDR 1292
Query: 94 FEDCPDGSDEENCTANPLLCSTARYHCK-NGLCIDKSFICDGQNNCQDNSDE 144
DC D SDE++C P C + ++ C + +C++ S +CDG +C + +DE
Sbjct: 1293 DNDCGDMSDEKDCPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDE 1344
Score = 84.7 bits (208), Expect = 1e-16
Identities = 49/132 (37%), Positives = 64/132 (48%), Gaps = 8/132 (6%)
Query: 24 NFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIH 83
N T C + F C NG CIP A+ CD DC D SDE C CG F C SG
Sbjct: 178 NCTEIC-LHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPT--CGGYQFTCPSG-R 233
Query: 84 CIIGRFRCNGFEDCPDGSDEENCTANPL---LCSTARYHC-KNGLCIDKSFICDGQNNCQ 139
CI + C+G +DC D DE+ C + P CS + C ++G CI +CDG +C
Sbjct: 234 CIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCP 293
Query: 140 DNSDEESCESSQ 151
DE + + +
Sbjct: 294 GREDENNTSTGK 305
Score = 84.7 bits (208), Expect = 1e-16
Identities = 47/126 (37%), Positives = 59/126 (46%), Gaps = 5/126 (3%)
Query: 24 NFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIH 83
N T F C G CIP ++CD DC D SDE+ C C F C +G
Sbjct: 2987 NCTRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGC--LYQTCQQNQFTCQNG-R 3043
Query: 84 CIIGRFRCNGFEDCPDGSDE--ENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDN 141
CI F C+ DC DGSDE C C + C NG CI+ +C+ ++C DN
Sbjct: 3044 CISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDN 3103
Query: 142 SDEESC 147
SDE+ C
Sbjct: 3104 SDEKGC 3109
Score = 83.2 bits (204), Expect = 3e-16
Identities = 43/120 (35%), Positives = 60/120 (50%), Gaps = 3/120 (2%)
Query: 33 GNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCN 92
G F CS+G C C+ +C D SDE C + CA+ CI ++C+
Sbjct: 3556 GQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANK-RCIPESWQCD 3614
Query: 93 GFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDE--ESCESS 150
F DC D SDE++ C ++ C NG CI +++ CD N+C D+SDE E C SS
Sbjct: 3615 TFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSS 3674
Score = 73.2 bits (178), Expect = 3e-13
Identities = 45/132 (34%), Positives = 62/132 (46%), Gaps = 10/132 (7%)
Query: 24 NFTNECNIPG---NFMCSNGRCIPGA----WQCDGLPDCFDKSDEKECPKAKS-KCGPTF 75
N +CN P N CS+ C PG QC + + ++ K C +CG +
Sbjct: 2646 NQKQQCNNPCEQFNGGCSH-ICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGERCGASS 2704
Query: 76 FPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQ 135
F C++G CI ++C+ DC DGSDE CS + C NG C+ S+ CD
Sbjct: 2705 FTCSNG-RCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYRCDYY 2763
Query: 136 NNCQDNSDEESC 147
N+C D SDE C
Sbjct: 2764 NDCGDGSDEAGC 2775
Score = 72.0 bits (175), Expect = 7e-13
Identities = 41/127 (32%), Positives = 59/127 (46%), Gaps = 15/127 (11%)
Query: 21 PGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCAS 80
P NF C P ++ C+G P E P +CG FPC +
Sbjct: 990 PVPNFQRVCGCPYGMRLASNHLT-----CEGDPT-------NEPPT--EQCGLFSFPCKN 1035
Query: 81 GIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQD 140
G C+ + C+G +DC D SDE+ C CS++ + C +G CI + CD +N+C D
Sbjct: 1036 G-RCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVD 1094
Query: 141 NSDEESC 147
SDE +C
Sbjct: 1095 GSDEHNC 1101
Score = 68.6 bits (166), Expect = 8e-12
Identities = 37/97 (38%), Positives = 47/97 (48%), Gaps = 4/97 (4%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGF 94
F C NG CI AW CD DC D SDEK+CP +C + C C+ C+G
Sbjct: 1276 FHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQCLGHNICVNLSVVCDGI 1335
Query: 95 EDCPDGSDEEN-CTANPLLCSTARYHCKNGLCIDKSF 130
DCP+G+DE C N CS C + C+ + F
Sbjct: 1336 FDCPNGTDESPLCNGNS--CSDFNGGCTHE-CVQEPF 1369
Score = 68.2 bits (165), Expect = 1e-11
Identities = 36/104 (34%), Positives = 51/104 (49%), Gaps = 5/104 (4%)
Query: 65 PKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKN-G 123
P + +C F C SG HCI +RC+G +DC D +DE C + C + C++ G
Sbjct: 22 PASGQECDSAHFRCGSG-HCIPADWRCDGTKDCSDDADEIGCAV--VTCQQGYFKCQSEG 78
Query: 124 LCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQVFVTSENQLV 167
CI S++CD +C D SDE + SQ S S Q +
Sbjct: 79 QCIPNSWVCDQDQDCDDGSDERQ-DCSQSTCSSHQITCSNGQCI 121
Score = 65.1 bits (157), Expect = 9e-11
Identities = 37/93 (39%), Positives = 43/93 (46%), Gaps = 8/93 (8%)
Query: 29 CNIPG----NFMCSNGRCIPGAWQCDGLPDCFDKSDEKEC---PKAKSKCGPTFFPCASG 81
CN P F C +GRCI W CDG DC D DE C P KC P + C
Sbjct: 217 CNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPES 276
Query: 82 IHCIIGRFRCNGFEDCPDGSDEENCTANPLLCS 114
CI C+G DCP G ++EN T+ CS
Sbjct: 277 GRCISIYKVCDGILDCP-GREDENNTSTGKYCS 308
Score = 61.2 bits (147), Expect = 1e-09
Identities = 34/81 (41%), Positives = 41/81 (50%), Gaps = 4/81 (4%)
Query: 29 CNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKE--CPKAKSK-CGPTFFPCASGIHCI 85
CN P F C N RCI C+G+ DC D +DE E C K K C + C +G HCI
Sbjct: 3883 CNSPNRFRCDNNRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNG-HCI 3941
Query: 86 IGRFRCNGFEDCPDGSDEENC 106
C+ +DC D SDE C
Sbjct: 3942 PHDNVCDDADDCGDWSDELGC 3962
Score = 59.3 bits (142), Expect = 5e-09
Identities = 29/81 (35%), Positives = 41/81 (50%), Gaps = 3/81 (3%)
Query: 71 CGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSF 130
C T F CA+ CI ++C+G +DC DGSD E C ++ C +G C
Sbjct: 3512 CSSTQFLCANNEKCIPIWWKCDGQKDCSDGSD-ELALCPQRFCRLGQFQCSDGNCTSPQT 3570
Query: 131 ICDGQNNCQDNSDEES--CES 149
+C+ NC D SDE+ CE+
Sbjct: 3571 LCNAHQNCPDGSDEDRLLCEN 3591
Score = 50.4 bits (119), Expect = 2e-06
Identities = 42/131 (32%), Positives = 58/131 (44%), Gaps = 26/131 (19%)
Query: 32 PGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKC-GPTFFPCASGIHCIIGRFR 90
P F C NGRCI C+ L DC D SDEK C ++C P+ C + F
Sbjct: 3077 PHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGC--GINECHDPSISGCDHNCTDTLTSFY 3134
Query: 91 CN---GFEDCPDGS---DEENCTANPLLCSTARYHCKNGLCIDKSFIC----------DG 134
C+ G++ D D + CT P +CS C+N + S+IC DG
Sbjct: 3135 CSCRPGYKLMSDKRTCVDIDECTEMPFVCS---QKCEN---VIGSYICKCAPGYLREPDG 3188
Query: 135 QNNCQDNSDEE 145
+ C+ NS+ E
Sbjct: 3189 K-TCRQNSNIE 3198
Score = 50.1 bits (118), Expect = 3e-06
Identities = 24/81 (29%), Positives = 36/81 (44%), Gaps = 10/81 (12%)
Query: 97 CPDG----SDEENCTANPL------LCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEES 146
CP G S+ C +P C + CKNG C+ ++CDG ++C DNSDE+
Sbjct: 1000 CPYGMRLASNHLTCEGDPTNEPPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQL 1059
Query: 147 CESSQEPGSGQVFVTSENQLV 167
C + S F + +
Sbjct: 1060 CGTLNNTCSSSAFTCGHGECI 1080
Score = 42.4 bits (98), Expect = 6e-04
Identities = 26/107 (24%), Positives = 42/107 (39%), Gaps = 6/107 (5%)
Query: 64 CPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTA-NPLLCSTARYHCKN 122
C + C P +G C +C + ++ ++C N C + + C N
Sbjct: 2655 CEQFNGGCSHICAPGPNGAEC-----QCPHEGNWYLANNRKHCIVDNGERCGASSFTCSN 2709
Query: 123 GLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQVFVTSENQLVYY 169
G CI + + CD N+C D SDE + S F + + V Y
Sbjct: 2710 GRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQY 2756
Score = 40.8 bits (94), Expect = 0.002
Identities = 38/132 (28%), Positives = 46/132 (34%), Gaps = 23/132 (17%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGI---HCI---IGR 88
+ C NG CIP CD DC D SDE C K K + CA I +C G
Sbjct: 3933 YKCGNGHCIPHDNVCDDADDCGDWSDELGCNKGKER------TCAENICEQNCTQLNEGG 3986
Query: 89 FRCN---GFE----DCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDN 141
F C+ GFE D D C T HC+N + DG + D
Sbjct: 3987 FICSCTAGFETNVFDRTSCLDINECEQ----FGTCPQHCRNTKGSYECVCADGFTSMSDR 4042
Query: 142 SDEESCESSQEP 153
+ P
Sbjct: 4043 PGKRCAAEGSSP 4054
Score = 35.4 bits (80), Expect = 0.075
Identities = 25/85 (29%), Positives = 38/85 (44%), Gaps = 8/85 (9%)
Query: 65 PKAKSKCGPTFFPCASGIHCIIGRFRCNGFE-DCPDGSDEENCTANPL---LCSTARYHC 120
P + CG C+ H + + GF +CPD + + +CS+ ++ C
Sbjct: 3463 PIVSNPCGTNNGGCS---HLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLC 3519
Query: 121 KNG-LCIDKSFICDGQNNCQDNSDE 144
N CI + CDGQ +C D SDE
Sbjct: 3520 ANNEKCIPIWWKCDGQKDCSDGSDE 3544
>gi|61744467 low density lipoprotein receptor-related protein 8
isoform 3 precursor [Homo sapiens]
Length = 700
Score = 119 bits (297), Expect = 5e-27
Identities = 60/159 (37%), Positives = 82/159 (51%), Gaps = 6/159 (3%)
Query: 11 LSSAAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSK 70
L++AA LL G +C F C N RCIP W+CD DC D SDE +CP K
Sbjct: 29 LAAAAADPLLGGQGPAKDCE-KDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCP--KKT 85
Query: 71 CGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHC--KNGLCIDK 128
C + F C +G HCI R++C+G E+CPDGSDE T +C + C + C+
Sbjct: 86 CADSDFTCDNG-HCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPA 144
Query: 129 SFICDGQNNCQDNSDEESCESSQEPGSGQVFVTSENQLV 167
S+ CDG+ +C+ +DE C +S G F + V
Sbjct: 145 SWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCV 183
Score = 32.7 bits (73), Expect = 0.49
Identities = 13/37 (35%), Positives = 19/37 (51%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKC 71
F C +G C+ C+ DC D SDE C + ++C
Sbjct: 175 FQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNEC 211
>gi|61744471 low density lipoprotein receptor-related protein 8
isoform 1 precursor [Homo sapiens]
Length = 963
Score = 117 bits (292), Expect = 2e-26
Identities = 57/145 (39%), Positives = 78/145 (53%), Gaps = 6/145 (4%)
Query: 11 LSSAAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSK 70
L++AA LL G +C F C N RCIP W+CD DC D SDE +CP K
Sbjct: 29 LAAAAADPLLGGQGPAKDCE-KDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCP--KKT 85
Query: 71 CGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHC--KNGLCIDK 128
C + F C +G HCI R++C+G E+CPDGSDE T +C + C + C+
Sbjct: 86 CADSDFTCDNG-HCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPA 144
Query: 129 SFICDGQNNCQDNSDEESCESSQEP 153
S+ CDG+ +C+ +DE C + P
Sbjct: 145 SWRCDGEKDCEGGADEAGCATLCAP 169
Score = 89.7 bits (221), Expect = 3e-18
Identities = 51/128 (39%), Positives = 66/128 (51%), Gaps = 14/128 (10%)
Query: 32 PGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCA--SGIHCIIGRF 89
P F C N C+ + CDG DC D SDE+ C A CGP F C G CI R+
Sbjct: 169 PHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC--ADPACGPREFRCGGDGGGACIPERW 226
Query: 90 RCNGFEDCPDGSDE--ENC-------TANPLLCSTA-RYHCKNGLCIDKSFICDGQNNCQ 139
C+ DC D SDE E C T+ P C+TA ++ C++G C+ + CDG +C+
Sbjct: 227 VCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCK 286
Query: 140 DNSDEESC 147
D SDE C
Sbjct: 287 DKSDEADC 294
Score = 75.9 bits (185), Expect = 5e-14
Identities = 44/117 (37%), Positives = 54/117 (46%), Gaps = 7/117 (5%)
Query: 14 AAESQLLPGNNFTNE---CNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSK 70
AAE PG T+ C F C +G C+ W+CDG DC DKSDE +CP
Sbjct: 241 AAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCP--LGT 298
Query: 71 CGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCID 127
C F C G C++ CN +DCPDGSDE C C C + +C D
Sbjct: 299 CRGDEFQCGDGT-CVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSH-ICTD 353
Score = 73.2 bits (178), Expect = 3e-13
Identities = 44/129 (34%), Positives = 56/129 (43%), Gaps = 16/129 (12%)
Query: 32 PGNFMCSN---GRCIPGAWQCDGLPDCFDKSDEKE---------CPKAKSKCGPTF-FPC 78
P F C G CIP W CD DC D+SDE A + C F C
Sbjct: 208 PREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFAC 267
Query: 79 ASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNC 138
SG C+ +RC+G DC D SDE +C C + C +G C+ C+ + +C
Sbjct: 268 RSG-ECVHLGWRCDGDRDCKDKSDEADCPLGT--CRGDEFQCGDGTCVLAIKHCNQEQDC 324
Query: 139 QDNSDEESC 147
D SDE C
Sbjct: 325 PDGSDEAGC 333
>gi|65301119 low density lipoprotein receptor-related protein 8
isoform 4 precursor [Homo sapiens]
Length = 904
Score = 117 bits (292), Expect = 2e-26
Identities = 57/145 (39%), Positives = 78/145 (53%), Gaps = 6/145 (4%)
Query: 11 LSSAAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSK 70
L++AA LL G +C F C N RCIP W+CD DC D SDE +CP K
Sbjct: 29 LAAAAADPLLGGQGPAKDCE-KDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCP--KKT 85
Query: 71 CGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHC--KNGLCIDK 128
C + F C +G HCI R++C+G E+CPDGSDE T +C + C + C+
Sbjct: 86 CADSDFTCDNG-HCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPA 144
Query: 129 SFICDGQNNCQDNSDEESCESSQEP 153
S+ CDG+ +C+ +DE C + P
Sbjct: 145 SWRCDGEKDCEGGADEAGCATLCAP 169
Score = 89.7 bits (221), Expect = 3e-18
Identities = 51/128 (39%), Positives = 66/128 (51%), Gaps = 14/128 (10%)
Query: 32 PGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCA--SGIHCIIGRF 89
P F C N C+ + CDG DC D SDE+ C A CGP F C G CI R+
Sbjct: 169 PHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC--ADPACGPREFRCGGDGGGACIPERW 226
Query: 90 RCNGFEDCPDGSDE--ENC-------TANPLLCSTA-RYHCKNGLCIDKSFICDGQNNCQ 139
C+ DC D SDE E C T+ P C+TA ++ C++G C+ + CDG +C+
Sbjct: 227 VCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCK 286
Query: 140 DNSDEESC 147
D SDE C
Sbjct: 287 DKSDEADC 294
Score = 75.9 bits (185), Expect = 5e-14
Identities = 44/117 (37%), Positives = 54/117 (46%), Gaps = 7/117 (5%)
Query: 14 AAESQLLPGNNFTNE---CNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSK 70
AAE PG T+ C F C +G C+ W+CDG DC DKSDE +CP
Sbjct: 241 AAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCP--LGT 298
Query: 71 CGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCID 127
C F C G C++ CN +DCPDGSDE C C C + +C D
Sbjct: 299 CRGDEFQCGDGT-CVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSH-ICTD 353
Score = 73.2 bits (178), Expect = 3e-13
Identities = 44/129 (34%), Positives = 56/129 (43%), Gaps = 16/129 (12%)
Query: 32 PGNFMCSN---GRCIPGAWQCDGLPDCFDKSDEKE---------CPKAKSKCGPTF-FPC 78
P F C G CIP W CD DC D+SDE A + C F C
Sbjct: 208 PREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFAC 267
Query: 79 ASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNC 138
SG C+ +RC+G DC D SDE +C C + C +G C+ C+ + +C
Sbjct: 268 RSG-ECVHLGWRCDGDRDCKDKSDEADCPLGT--CRGDEFQCGDGTCVLAIKHCNQEQDC 324
Query: 139 QDNSDEESC 147
D SDE C
Sbjct: 325 PDGSDEAGC 333
>gi|66082554 low density lipoprotein receptor-related protein 8
isoform 2 precursor [Homo sapiens]
Length = 793
Score = 116 bits (291), Expect = 3e-26
Identities = 56/139 (40%), Positives = 76/139 (54%), Gaps = 6/139 (4%)
Query: 11 LSSAAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSK 70
L++AA LL G +C F C N RCIP W+CD DC D SDE +CP K
Sbjct: 29 LAAAAADPLLGGQGPAKDCE-KDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCP--KKT 85
Query: 71 CGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHC--KNGLCIDK 128
C + F C +G HCI R++C+G E+CPDGSDE T +C + C + C+
Sbjct: 86 CADSDFTCDNG-HCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPA 144
Query: 129 SFICDGQNNCQDNSDEESC 147
S+ CDG+ +C+ +DE C
Sbjct: 145 SWRCDGEKDCEGGADEAGC 163
Score = 58.9 bits (141), Expect = 6e-09
Identities = 29/91 (31%), Positives = 46/91 (50%), Gaps = 10/91 (10%)
Query: 62 KECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCK 121
K+C K + +C CI +RC+ +DC D SDE++C C+ + + C
Sbjct: 45 KDCEKDQFQC--------RNERCIPSVWRCDEDDDCLDHSDEDDCPKKT--CADSDFTCD 94
Query: 122 NGLCIDKSFICDGQNNCQDNSDEESCESSQE 152
NG CI + + CDG+ C D SDE +++
Sbjct: 95 NGHCIHERWKCDGEEECPDGSDESEATCTKQ 125
Score = 36.2 bits (82), Expect = 0.044
Identities = 12/31 (38%), Positives = 19/31 (61%)
Query: 41 RCIPGAWQCDGLPDCFDKSDEKECPKAKSKC 71
+C+P +W+CDG DC +DE C ++C
Sbjct: 140 KCVPASWRCDGEKDCEGGADEAGCATWLNEC 170
>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
Length = 4544
Score = 115 bits (287), Expect = 7e-26
Identities = 60/133 (45%), Positives = 73/133 (54%), Gaps = 11/133 (8%)
Query: 22 GNNFTNECNIP-----GNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFF 76
G+N E P F C+NGRCI G W+CDG DC D SDEK+C +C F
Sbjct: 3562 GDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTP---RCDMDQF 3618
Query: 77 PCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQN 136
C SG HCI R+RC+ DC DGSDEE C C + C N LC ++ CDG++
Sbjct: 3619 QCKSG-HCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGED 3677
Query: 137 NCQDNSDE--ESC 147
+C DNSDE E C
Sbjct: 3678 DCGDNSDENPEEC 3690
Score = 108 bits (269), Expect = 9e-24
Identities = 53/123 (43%), Positives = 72/123 (58%), Gaps = 8/123 (6%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDE------KECPKAKSKCGPTFFPCASGIHCIIGR 88
F C++GRCIP W CDG DC D SDE + + C F C CI R
Sbjct: 1020 FKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLR 1079
Query: 89 FRCNGFEDCPDGSDEENCTANPLLCS-TARYHCKNGL-CIDKSFICDGQNNCQDNSDEES 146
+RC+G DC D SDE++C +C + ++ CK+ CI K+++CDG N+C+DNSDEE+
Sbjct: 1080 WRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEEN 1139
Query: 147 CES 149
CES
Sbjct: 1140 CES 1142
Score = 108 bits (269), Expect = 9e-24
Identities = 54/128 (42%), Positives = 71/128 (55%), Gaps = 5/128 (3%)
Query: 21 PGNNFTNECNIPGNFMCSN-GRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCA 79
P N C + F C + GRCIP W+CDG DC D SDE + + C P F C
Sbjct: 3486 PANCTQMTCGVD-EFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCK 3544
Query: 80 SGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQ 139
+ C+ GR++C+ DC D SDEE+CT P CS + + C NG CI + CDG ++C
Sbjct: 3545 NN-RCVPGRWQCDYDNDCGDNSDEESCTPRP--CSESEFSCANGRCIAGRWKCDGDHDCA 3601
Query: 140 DNSDEESC 147
D SDE+ C
Sbjct: 3602 DGSDEKDC 3609
Score = 103 bits (257), Expect = 2e-22
Identities = 49/124 (39%), Positives = 67/124 (54%), Gaps = 3/124 (2%)
Query: 27 NECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCII 86
+ C F C+NG CI + CDG+P C DKSDEK +C TF C++G C+
Sbjct: 2522 SSCRAQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNG-RCVS 2580
Query: 87 GRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEES 146
CNG +DC DGSDE C N C + C++G CI S C+ +C+D SDE +
Sbjct: 2581 NMLWCNGADDCGDGSDEIPC--NKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMN 2638
Query: 147 CESS 150
C ++
Sbjct: 2639 CSAT 2642
Score = 101 bits (252), Expect = 9e-22
Identities = 49/116 (42%), Positives = 60/116 (51%), Gaps = 1/116 (0%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGF 94
F C N RCIP W CDG DC + DE + C P F CASG CI + C+
Sbjct: 900 FKCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASG-RCIPISWTCDLD 958
Query: 95 EDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESS 150
+DC D SDE A P ++ C NG CI+ ++ CD N+C DNSDE C S
Sbjct: 959 DDCGDRSDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHS 1014
Score = 101 bits (252), Expect = 9e-22
Identities = 51/118 (43%), Positives = 62/118 (52%), Gaps = 4/118 (3%)
Query: 32 PGNFMCS-NGRCIPGAWQCDGLPDCFDKSDEK-ECPKAKSKCGPTFFPCASGIHCIIGRF 89
P F CS RCIP W CD DC D SDE C + CG F C CI R+
Sbjct: 3455 PNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANC--TQMTCGVDEFRCKDSGRCIPARW 3512
Query: 90 RCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESC 147
+C+G +DC DGSDE + C ++ CKN C+ + CD N+C DNSDEESC
Sbjct: 3513 KCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESC 3570
Score = 100 bits (249), Expect = 2e-21
Identities = 62/166 (37%), Positives = 81/166 (48%), Gaps = 17/166 (10%)
Query: 7 LCLLLSSAAESQLLPGNNF--------TNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDK 58
LCLL P N + + C F+C N +CIP W+CD DC D
Sbjct: 3304 LCLLSPGGGHKCACPTNFYLGSDGRTCVSNCTA-SQFVCKNDKCIPFWWKCDTEDDCGDH 3362
Query: 59 SDE-KECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTAR 117
SDE +CP + KC P F C++GI C F C+G DC D SDE NC + +C ++
Sbjct: 3363 SDEPPDCP--EFKCRPGQFQCSTGI-CTNPAFICDGDNDCQDNSDEANCDIH--VCLPSQ 3417
Query: 118 YHCKN-GLCIDKSFICDGQNNCQDNSDEESC-ESSQEPGSGQVFVT 161
+ C N CI F C+GQ+NC D DE C E + P Q +T
Sbjct: 3418 FKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSIT 3463
Score = 97.8 bits (242), Expect = 1e-20
Identities = 54/136 (39%), Positives = 68/136 (50%), Gaps = 13/136 (9%)
Query: 24 NFTNECNIP------GNFMCS-NGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTF- 75
N TN+ P F C +G CIP W+CDG DC D SDEK C C P+
Sbjct: 1050 NCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVK 1109
Query: 76 FPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNG--LCIDKSFICD 133
F C CI + C+G DC D SDEENC + L C + C N +C+ +CD
Sbjct: 1110 FGCKDSARCISKAWVCDGDNDCEDNSDEENCES--LACRPPSHPCANNTSVCLPPDKLCD 1167
Query: 134 GQNNCQDNSDE-ESCE 148
G ++C D SDE E C+
Sbjct: 1168 GNDDCGDGSDEGELCD 1183
Score = 97.1 bits (240), Expect = 2e-20
Identities = 50/114 (43%), Positives = 66/114 (57%), Gaps = 6/114 (5%)
Query: 32 PGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGP-TFFPCASGIHCIIGRFR 90
P F C++GRCIP +W CD DC D+SDE A C P T F C +G CI +R
Sbjct: 938 PNQFSCASGRCIPISWTCDLDDDCGDRSDE-SASCAYPTCFPLTQFTCNNG-RCININWR 995
Query: 91 CNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDE 144
C+ DC D SDE C+ + CS+ ++ C +G CI + + CDG N+C D SDE
Sbjct: 996 CDNDNDCGDNSDEAGCSHS---CSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDE 1046
Score = 95.9 bits (237), Expect = 5e-20
Identities = 46/109 (42%), Positives = 63/109 (57%), Gaps = 6/109 (5%)
Query: 42 CIPGAWQCDGLPDCFDKSDEKECPKAK-SKCGPTFFPCASGIHCIIGRFRCNGFEDCPDG 100
C +W CDG DC D SDE++CP K +C +F C SG CI + C+ +DC G
Sbjct: 2666 CYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPSG-RCIPMSWTCDKEDDCEHG 2724
Query: 101 SDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEES-CE 148
DE +C CS A++ C+N CI K ++CDG ++C D SDE + CE
Sbjct: 2725 EDETHCNK---FCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCE 2770
Score = 95.9 bits (237), Expect = 5e-20
Identities = 52/140 (37%), Positives = 73/140 (52%), Gaps = 7/140 (5%)
Query: 31 IPGNFMCSN-GRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRF 89
+P F C+N RCIPG ++C+G +C D DE++CP+ C P F C+ CI +
Sbjct: 3414 LPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVT--CAPNQFQCSITKRCIPRVW 3471
Query: 90 RCNGFEDCPDGSDEE-NCTANPLLCSTARYHCKN-GLCIDKSFICDGQNNCQDNSDEESC 147
C+ DC DGSDE NCT + C + CK+ G CI + CDG+++C D SDE
Sbjct: 3472 VCDRDNDCVDGSDEPANCTQ--MTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKE 3529
Query: 148 ESSQEPGSGQVFVTSENQLV 167
E + F N+ V
Sbjct: 3530 ECDERTCEPYQFRCKNNRCV 3549
Score = 95.1 bits (235), Expect = 8e-20
Identities = 48/114 (42%), Positives = 62/114 (54%), Gaps = 5/114 (4%)
Query: 32 PGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRC 91
PG F CS G C A+ CDG DC D SDE C C P+ F C + CI G FRC
Sbjct: 3376 PGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDI--HVCLPSQFKCTNTNRCIPGIFRC 3433
Query: 92 NGFEDCPDGSDEENCTANPLLCSTARYHCK-NGLCIDKSFICDGQNNCQDNSDE 144
NG ++C DG DE +C + C+ ++ C CI + ++CD N+C D SDE
Sbjct: 3434 NGQDNCGDGEDERDCP--EVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDE 3485
Score = 94.4 bits (233), Expect = 1e-19
Identities = 52/147 (35%), Positives = 83/147 (56%), Gaps = 11/147 (7%)
Query: 12 SSAAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEK-ECPKAKSK 70
+ A+ + G + + C+ FMC N +CIP + CD DC D SDE EC
Sbjct: 2801 ADGADESIAAGCLYNSTCD-DREFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPT-- 2857
Query: 71 CGPTFFPCASGIHCIIGR-FRCNGFEDCPDGSDEE----NCTANPLLCS-TARYHCKNGL 124
CGP+ F CA+G C+ R + C+G DC D SDE +CT+ C+ ++++ C +G
Sbjct: 2858 CGPSEFRCANG-RCLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGR 2916
Query: 125 CIDKSFICDGQNNCQDNSDEESCESSQ 151
C+ ++ +C+GQ++C D+SDE C ++
Sbjct: 2917 CVAEALLCNGQDDCGDSSDERGCHINE 2943
Score = 88.6 bits (218), Expect = 7e-18
Identities = 49/119 (41%), Positives = 68/119 (57%), Gaps = 7/119 (5%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTF-FPCASGIHCI-IGRFRCN 92
F C+N C P AW+CDG DC D SDE A+ C P F C + C+ IGR +C+
Sbjct: 3659 FQCNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGR-QCD 3717
Query: 93 GFEDCPDGSDEENC---TANPLLCSTAR-YHCKNGLCIDKSFICDGQNNCQDNSDEESC 147
G ++C DG+DEE+C TA+ C + + C+N C+ S C+ ++C D SDEE C
Sbjct: 3718 GTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDC 3776
Score = 84.7 bits (208), Expect = 1e-16
Identities = 50/155 (32%), Positives = 63/155 (40%), Gaps = 42/155 (27%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSK------------------------ 70
F C +GRCIP +W CD DC DE C K S+
Sbjct: 2701 FACPSGRCIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCG 2760
Query: 71 -------------CGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEE---NCTANPLLCS 114
CGP+ F C C+ R+ C+G +DC DG+DE C N C
Sbjct: 2761 DGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNS-TCD 2819
Query: 115 TARYHCKNGLCIDKSFICDGQNNCQDNSDEE-SCE 148
+ C+N CI K F+CD +C D SDE CE
Sbjct: 2820 DREFMCQNRQCIPKHFVCDHDRDCADGSDESPECE 2854
Score = 75.1 bits (183), Expect = 9e-14
Identities = 42/130 (32%), Positives = 61/130 (46%), Gaps = 6/130 (4%)
Query: 26 TNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKS-----KCGPTFFPCAS 80
TN+C + S PG+ QC D +D C S +C P F CA+
Sbjct: 804 TNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACAN 863
Query: 81 GIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQD 140
CI R++C+G DC D SDE + C + R+ C+N CI ++CDG N+C +
Sbjct: 864 S-RCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGN 922
Query: 141 NSDEESCESS 150
+ DE + S
Sbjct: 923 SEDESNATCS 932
Score = 73.6 bits (179), Expect = 2e-13
Identities = 40/101 (39%), Positives = 52/101 (51%), Gaps = 11/101 (10%)
Query: 22 GNNFTNECNIP----GNFMCSNGRCIPGA-WQCDGLPDCFDKSDEK----ECPKAKSKCG 72
G++ + EC P F C+NGRC+ W+CDG DC D+SDE C + KC
Sbjct: 2846 GSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCN 2905
Query: 73 PTF-FPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLL 112
+ F C+SG C+ CNG +DC D SDE C N L
Sbjct: 2906 ASSQFLCSSG-RCVAEALLCNGQDDCGDSSDERGCHINECL 2945
Score = 63.2 bits (152), Expect = 3e-10
Identities = 44/124 (35%), Positives = 59/124 (47%), Gaps = 18/124 (14%)
Query: 35 FMCSNGR-CIPGAWQCDGLPDCFDKSDEKEC--PKAKSK-CGPTFFPCASGIHCIIGRFR 90
F C N R C+ QCDG +C D +DE++C P A + C C+ R
Sbjct: 3701 FRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLR 3760
Query: 91 CNGFEDCPDGSDEENCTANPLL--CSTARYHC-KNGLCI--DKSFIC---------DGQN 136
CN F+DC DGSDEE+C+ +P L C+T C C+ +K+ C GQ
Sbjct: 3761 CNMFDDCGDGSDEEDCSIDPKLTSCATNASICGDEARCVRTEKAAYCACRSGFHTVPGQP 3820
Query: 137 NCQD 140
CQD
Sbjct: 3821 GCQD 3824
Score = 62.4 bits (150), Expect = 6e-10
Identities = 49/157 (31%), Positives = 71/157 (45%), Gaps = 11/157 (7%)
Query: 3 LLGPLCLLLSSAAESQLLPGNNFTNECNIPGNFMCSNG-RCIPGAWQCDGLPDCFDKSDE 61
+L P LLL + + + C+ P F C + CI W+CDG DC D SDE
Sbjct: 1 MLTPPLLLLLPLLSALVAAAIDAPKTCS-PKQFACRDQITCISKGWRCDGERDCPDGSDE 59
Query: 62 KE--CPKAKS-KCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDE-ENCTANPLLCST-- 115
CP++K+ +C P C C+ CNG +DC DGSDE +C CS
Sbjct: 60 APEICPQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLG 119
Query: 116 ARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQE 152
++HC L C ++ Q +D ++C+ E
Sbjct: 120 CQHHCVPTL---DGPTCYCNSSFQLQADGKTCKDFDE 153
Score = 50.8 bits (120), Expect = 2e-06
Identities = 38/128 (29%), Positives = 51/128 (39%), Gaps = 22/128 (17%)
Query: 16 ESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKEC---PKA----- 67
E P T C F+C N RC+ + +C+ DC D SDE++C PK
Sbjct: 3728 EEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCAT 3787
Query: 68 -KSKCG----------PTFFPCASGIHCIIGRFRCNGFEDC-PDGSDEENC--TANPLLC 113
S CG + C SG H + G+ C +C G+ + C T LC
Sbjct: 3788 NASICGDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQLCNNTKGGHLC 3847
Query: 114 STARYHCK 121
S AR K
Sbjct: 3848 SCARNFMK 3855
Score = 50.1 bits (118), Expect = 3e-06
Identities = 37/139 (26%), Positives = 51/139 (36%), Gaps = 44/139 (31%)
Query: 27 NECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECP--------------------- 65
++CN F+CS+GRC+ A C+G DC D SDE+ C
Sbjct: 2902 HKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHINECLSRKLSGCSQDCEDLKI 2961
Query: 66 KAKSKCGPTF------------------FPCASGIHCIIGRFRCNGFED-CPDGSDEENC 106
K +C P F FPC+ G ++C E P G D +C
Sbjct: 2962 GFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTHGSYKCLCVEGYAPRGGDPHSC 3021
Query: 107 TA----NPLLCSTARYHCK 121
A P L RY+ +
Sbjct: 3022 KAVTDEEPFLIFANRYYLR 3040
Score = 49.7 bits (117), Expect = 4e-06
Identities = 32/113 (28%), Positives = 44/113 (38%), Gaps = 5/113 (4%)
Query: 60 DEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLL-----CS 114
D ++ +KC C+S G +C ED +D C ANP C
Sbjct: 796 DAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQ 855
Query: 115 TARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQVFVTSENQLV 167
+ C N CI + + CDG N+C DNSDE Q F N+ +
Sbjct: 856 PGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCI 908
>gi|157384998 low density lipoprotein receptor-related protein 4
[Homo sapiens]
Length = 1905
Score = 115 bits (287), Expect = 7e-26
Identities = 55/125 (44%), Positives = 77/125 (61%), Gaps = 5/125 (4%)
Query: 29 CNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGR 88
CN+ F C+ GRCI + CDG DC D SDE +C + C F C SG+ CI
Sbjct: 191 CNLE-EFQCAYGRCILDIYHCDGDDDCGDWSDESDC-SSHQPCRSGEFMCDSGL-CINAG 247
Query: 89 FRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCE 148
+RC+G DC D SDE NCT + +C+ ++ C +G C+ S+ CDG+++C DNSDEE+CE
Sbjct: 248 WRCDGDADCDDQSDERNCTTS--MCTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCE 305
Query: 149 SSQEP 153
++ P
Sbjct: 306 NTGSP 310
Score = 110 bits (274), Expect = 2e-24
Identities = 57/127 (44%), Positives = 77/127 (60%), Gaps = 7/127 (5%)
Query: 33 GNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCN 92
G FMC +G CI W+CDG DC D+SDE+ C S C F C SG C+ +RC+
Sbjct: 234 GEFMCDSGLCINAGWRCDGDADCDDQSDERNC--TTSMCTAEQFRCHSG-RCVRLSWRCD 290
Query: 93 GFEDCPDGSDEENC--TANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESS 150
G +DC D SDEENC T +P C+ ++ C NG CI + +C+G N+C DNSD ES + +
Sbjct: 291 GEDDCADNSDEENCENTGSPQ-CALDQFLCWNGRCIGQRKLCNGVNDCGDNSD-ESPQQN 348
Query: 151 QEPGSGQ 157
P +G+
Sbjct: 349 CRPRTGE 355
Score = 109 bits (272), Expect = 4e-24
Identities = 51/119 (42%), Positives = 71/119 (59%), Gaps = 6/119 (5%)
Query: 32 PGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRC 91
P +F C NG+CI +W CDG DC D SDE++CP +C FPC +G +CI + C
Sbjct: 73 PLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCP--PRECEEDEFPCQNG-YCIRSLWHC 129
Query: 92 NGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESS 150
+G DC D SDE+ + CS + C +G CI + + CDG +C+D SDEE+C S+
Sbjct: 130 DGDNDCGDNSDEQ---CDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSA 185
Score = 101 bits (252), Expect = 9e-22
Identities = 57/130 (43%), Positives = 68/130 (52%), Gaps = 6/130 (4%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGF 94
F C NG CI W CDG DC D SDE +C K C F C+ G CI + C+G
Sbjct: 115 FPCQNGYCIRSLWHCDGDNDCGDNSDE-QCDMRK--CSDKEFRCSDG-SCIAEHWYCDGD 170
Query: 95 EDCPDGSDEENC-TANPLL-CSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQE 152
DC DGSDEENC +A P C+ + C G CI + CDG ++C D SDE C S Q
Sbjct: 171 TDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQP 230
Query: 153 PGSGQVFVTS 162
SG+ S
Sbjct: 231 CRSGEFMCDS 240
Score = 96.7 bits (239), Expect = 3e-20
Identities = 58/144 (40%), Positives = 74/144 (51%), Gaps = 11/144 (7%)
Query: 3 LLGPLCLLLSSAAESQLLPG-NNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDE 61
LLG L A+ + G ++FT C + C+ CIP WQCDG DC D SDE
Sbjct: 9 LLGALLCAHGLASSPECACGRSHFT--CAVSALGECT---CIPAQWQCDGDNDCGDHSDE 63
Query: 62 KECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCK 121
C C P F C +G CI + C+G DC D SDE++C P C + C+
Sbjct: 64 DGC--ILPTCSPLDFHCDNG-KCIRRSWVCDGDNDCEDDSDEQDCP--PRECEEDEFPCQ 118
Query: 122 NGLCIDKSFICDGQNNCQDNSDEE 145
NG CI + CDG N+C DNSDE+
Sbjct: 119 NGYCIRSLWHCDGDNDCGDNSDEQ 142
Score = 79.0 bits (193), Expect = 6e-15
Identities = 35/81 (43%), Positives = 49/81 (60%), Gaps = 6/81 (7%)
Query: 71 CGPTFFPCASGI----HCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCI 126
CG + F CA CI +++C+G DC D SDE+ C CS +HC NG CI
Sbjct: 27 CGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPT--CSPLDFHCDNGKCI 84
Query: 127 DKSFICDGQNNCQDNSDEESC 147
+S++CDG N+C+D+SDE+ C
Sbjct: 85 RRSWVCDGDNDCEDDSDEQDC 105
Score = 71.6 bits (174), Expect = 9e-13
Identities = 45/121 (37%), Positives = 55/121 (45%), Gaps = 12/121 (9%)
Query: 24 NFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKS-KCGPTFFPCASGI 82
N T F C +GRC+ +W+CDG DC D SDE+ C S +C F C +G
Sbjct: 264 NCTTSMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNG- 322
Query: 83 HCIIGRFRCNGFEDCPDGSDE---ENCTANPLLCSTARYHC--KNGLCIDKSFICDGQNN 137
CI R CNG DC D SDE +NC T +C NG C K + G
Sbjct: 323 RCIGQRKLCNGVNDCGDNSDESPQQNCRPR-----TGEENCNVNNGGCAQKCQMVRGAVQ 377
Query: 138 C 138
C
Sbjct: 378 C 378
>gi|93102379 low density lipoprotein-related protein 1B precursor
[Homo sapiens]
Length = 4599
Score = 112 bits (280), Expect = 5e-25
Identities = 53/133 (39%), Positives = 71/133 (53%), Gaps = 6/133 (4%)
Query: 32 PGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRC 91
P F C N CIP W+CD DC D SDE+ C C F CA+G C+ RF C
Sbjct: 3478 PHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKP--QTCTLKDFLCANG-DCVSSRFWC 3534
Query: 92 NGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQ 151
+G DC DGSDE NC + CS ++ C NG CI + CDG +C+ DE+SCE +
Sbjct: 3535 DGDFDCADGSDERNCETS---CSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPAS 3591
Query: 152 EPGSGQVFVTSEN 164
S + ++ + +
Sbjct: 3592 PTCSSREYICASD 3604
Score = 110 bits (274), Expect = 2e-24
Identities = 53/123 (43%), Positives = 73/123 (59%), Gaps = 8/123 (6%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKE--CPK----AKSKCGPTFFPCASGIHCIIGR 88
F CS+GRCIPG W CDG DC D SDE + C K + + C F C +C+
Sbjct: 1011 FRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDL 1070
Query: 89 FRCNGFEDCPDGSDEENCTANPLLCS-TARYHC-KNGLCIDKSFICDGQNNCQDNSDEES 146
+RC+G +DC DGSDE+ C LC ++ C G CI+K+++CDG +C+D SDE+
Sbjct: 1071 WRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDD 1130
Query: 147 CES 149
C+S
Sbjct: 1131 CDS 1133
Score = 110 bits (274), Expect = 2e-24
Identities = 53/115 (46%), Positives = 65/115 (56%), Gaps = 5/115 (4%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGF 94
F CSNG+CIP W+CDG DC DEK C A C + CAS CI +CNG
Sbjct: 3558 FRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICASD-GCISASLKCNGE 3616
Query: 95 EDCPDGSDEENCTANPLLCSTARYHCKNGL-CIDKSFICDGQNNCQDNSDEESCE 148
DC DGSDE +C C ++ CKN CI ++CDG ++C D SDEE+CE
Sbjct: 3617 YDCADGSDEMDCVTE---CKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCE 3668
Score = 109 bits (273), Expect = 3e-24
Identities = 52/124 (41%), Positives = 72/124 (58%), Gaps = 6/124 (4%)
Query: 26 TNECNIPGNFMCS-NGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHC 84
T+ C + G F C+ N +CIP +C+G DC D+ DE++CP+ + C P +F C + HC
Sbjct: 3393 THVC-LSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPE--NSCSPDYFQCKTTKHC 3449
Query: 85 IIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDE 144
I + C+ DC D SDE NC C + CKN CI + CD QN+C DNSDE
Sbjct: 3450 ISKLWVCDEDPDCADASDEANCDKKT--CGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDE 3507
Query: 145 ESCE 148
E+C+
Sbjct: 3508 ENCK 3511
Score = 107 bits (268), Expect = 1e-23
Identities = 55/125 (44%), Positives = 67/125 (53%), Gaps = 7/125 (5%)
Query: 27 NECNIPGNFMCSNGR-CIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCI 85
N C+ P F C + CI W CD PDC D SDE C K CGP F C + +CI
Sbjct: 3434 NSCS-PDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDK--KTCGPHEFQCKNN-NCI 3489
Query: 86 IGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEE 145
+RC+ DC D SDEENC P C+ + C NG C+ F CDG +C D SDE
Sbjct: 3490 PDHWRCDSQNDCSDNSDEENC--KPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDER 3547
Query: 146 SCESS 150
+CE+S
Sbjct: 3548 NCETS 3552
Score = 99.8 bits (247), Expect = 3e-21
Identities = 45/114 (39%), Positives = 66/114 (57%), Gaps = 4/114 (3%)
Query: 34 NFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNG 93
+F+C+NG C+ + CDG DC D SDE+ C ++ C F C++G CI +++C+G
Sbjct: 3519 DFLCANGDCVSSRFWCDGDFDCADGSDERNC---ETSCSKDQFRCSNG-QCIPAKWKCDG 3574
Query: 94 FEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESC 147
EDC G DE++C CS+ Y C + CI S C+G+ +C D SDE C
Sbjct: 3575 HEDCKYGEDEKSCEPASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDC 3628
Score = 98.2 bits (243), Expect = 9e-21
Identities = 56/157 (35%), Positives = 75/157 (47%), Gaps = 16/157 (10%)
Query: 7 LCLLLS-----SAAESQLLPGNNFTNECN----IP-----GNFMCSNGRCIPGAWQCDGL 52
LCL + + A++QLL N T N +P G F C N CI W+CDG
Sbjct: 808 LCLAIPGGRVCACADNQLLDENGTTCTFNPGEALPHICKAGEFRCKNRHCIQARWKCDGD 867
Query: 53 PDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLL 112
DC D SDE C F C + CI R+ C+G DC DE N T
Sbjct: 868 DDCLDGSDEDSVNCFNHSCPDDQFKCQNN-RCIPKRWLCDGANDCGSNEDESNQTCTART 926
Query: 113 CSTARYHCKNGLCIDKSFICDGQNNCQDNSDE-ESCE 148
C ++ C NG CI ++++CD +++C D +DE SCE
Sbjct: 927 CQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCE 963
Score = 97.1 bits (240), Expect = 2e-20
Identities = 50/119 (42%), Positives = 66/119 (55%), Gaps = 6/119 (5%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGP-TFFPCASGIHCIIGRFRCNG 93
F C NGRCIP AW CD DC D++DE + + C P T F C SG CI ++ C+
Sbjct: 932 FSCGNGRCIPRAWLCDREDDCGDQTDEMASCEFPT-CEPLTQFVCKSG-RCISSKWHCDS 989
Query: 94 FEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQE 152
+DC DGSDE C + C ++ C +G CI + CDG N+C D SDE ++E
Sbjct: 990 DDDCGDGSDEVGCVHS---CFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKE 1045
Score = 97.1 bits (240), Expect = 2e-20
Identities = 57/157 (36%), Positives = 79/157 (50%), Gaps = 15/157 (9%)
Query: 7 LCLLLSSAAESQLLPGNNFTNECN-------IPGNFMCSNGRCIPGAWQCDGLPDCFDKS 59
LCLL + P N + N F C +CIP W+CD + DC D S
Sbjct: 3287 LCLLAPGKTHTCACPTNFYLAADNRTCLSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGS 3346
Query: 60 DE-KECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARY 118
DE +CP + +C P F C +G+ C + F C+G DC D SDE NC + +C + ++
Sbjct: 3347 DEPDDCP--EFRCQPGRFQCGTGL-CALPAFICDGENDCGDNSDELNCDTH--VCLSGQF 3401
Query: 119 HC-KNGLCIDKSFICDGQNNCQDNSDEESC-ESSQEP 153
C KN CI + C+GQ++C D DE C E+S P
Sbjct: 3402 KCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENSCSP 3438
Score = 95.1 bits (235), Expect = 8e-20
Identities = 48/124 (38%), Positives = 64/124 (51%), Gaps = 3/124 (2%)
Query: 27 NECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCII 86
+ CN F C NG CI CDG+P C DKSDEK C F PC + CI
Sbjct: 2508 SSCNAYSEFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNR-RCIP 2566
Query: 87 GRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEES 146
C+G DC D SDE +C + C+T + C +G CI +S C+ +C D SDE++
Sbjct: 2567 HGKLCDGENDCGDNSDELDCKVST--CATVEFRCADGTCIPRSARCNQNIDCADASDEKN 2624
Query: 147 CESS 150
C ++
Sbjct: 2625 CNNT 2628
Score = 93.2 bits (230), Expect = 3e-19
Identities = 50/129 (38%), Positives = 67/129 (51%), Gaps = 11/129 (8%)
Query: 29 CNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGR 88
C F+C +GRCI W CD DC D SDE C + C F C+SG CI G
Sbjct: 967 CEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHS---CFDNQFRCSSG-RCIPGH 1022
Query: 89 FRCNGFEDCPDGSDEE--NCTA----NPLLCSTARYHCK-NGLCIDKSFICDGQNNCQDN 141
+ C+G DC D SDE NCT +P C+ + C +G C+ + CDG+ +C+D
Sbjct: 1023 WACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCEDG 1082
Query: 142 SDEESCESS 150
SDE+ C +
Sbjct: 1083 SDEKGCNGT 1091
Score = 91.3 bits (225), Expect = 1e-18
Identities = 47/122 (38%), Positives = 67/122 (54%), Gaps = 7/122 (5%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEK-ECPKAKSKCGPTFFPCASGIHCIIGRFRCNG 93
FMC N CIP + CD DC D SDE +C +CG F CA G + +++C+G
Sbjct: 2810 FMCHNKVCIPKQFVCDHDDDCGDGSDESPQC--GYRQCGTEEFSCADGRCLLNTQWQCDG 2867
Query: 94 FEDCPDGSDEE----NCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCES 149
DCPD SDE C + C+++ + CKNG CI +CD +++C D SDE +C
Sbjct: 2868 DFDCPDHSDEAPLNPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHI 2927
Query: 150 SQ 151
++
Sbjct: 2928 NE 2929
Score = 89.4 bits (220), Expect = 4e-18
Identities = 44/113 (38%), Positives = 54/113 (47%), Gaps = 4/113 (3%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGF 94
F CS +CI W CDG DC D DE + C F C C+ + C+G
Sbjct: 2725 FACSAQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMFSCQGSRACVPRHWLCDGE 2784
Query: 95 EDCPDGSDE---ENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDE 144
DCPDGSDE C N C + C N +CI K F+CD ++C D SDE
Sbjct: 2785 RDCPDGSDELSTAGCAPNN-TCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDE 2836
Score = 89.0 bits (219), Expect = 6e-18
Identities = 48/124 (38%), Positives = 64/124 (51%), Gaps = 8/124 (6%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKS----KCGPT---FFPCASGIHCIIG 87
F C++G CIP + +C+ DC D SDEK C K G F C S C++
Sbjct: 2596 FRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLP 2655
Query: 88 RFRCNGFEDCPDGSDEENCTA-NPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEES 146
+ C+G DC D SDE C N C + C +G CI ++ICDGQ +C+D DE
Sbjct: 2656 TWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQKDCEDGRDEFH 2715
Query: 147 CESS 150
C+SS
Sbjct: 2716 CDSS 2719
Score = 87.8 bits (216), Expect = 1e-17
Identities = 43/113 (38%), Positives = 58/113 (51%), Gaps = 5/113 (4%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGF 94
F C +GRCI W CDG DC D DE C S C F C S CI + C+G
Sbjct: 2687 FSCPSGRCILNTWICDGQKDCEDGRDEFHC---DSSCSWNQFAC-SAQKCISKHWICDGE 2742
Query: 95 EDCPDGSDEENCTANPLLCSTARYHCKNG-LCIDKSFICDGQNNCQDNSDEES 146
+DC DG DE + + C+ + C+ C+ + ++CDG+ +C D SDE S
Sbjct: 2743 DDCGDGLDESDSICGAITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDELS 2795
Score = 85.5 bits (210), Expect = 6e-17
Identities = 45/128 (35%), Positives = 57/128 (44%), Gaps = 2/128 (1%)
Query: 23 NNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGI 82
N F + C F C N RCIP W CDG DC DE C F C +G
Sbjct: 880 NCFNHSCP-DDQFKCQNNRCIPKRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNG- 937
Query: 83 HCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNS 142
CI + C+ +DC D +DE P ++ CK+G CI + CD ++C D S
Sbjct: 938 RCIPRAWLCDREDDCGDQTDEMASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGS 997
Query: 143 DEESCESS 150
DE C S
Sbjct: 998 DEVGCVHS 1005
Score = 83.2 bits (204), Expect = 3e-16
Identities = 50/126 (39%), Positives = 63/126 (50%), Gaps = 13/126 (10%)
Query: 29 CNIPGNFMC-SNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIH-CII 86
C+ F C S GRCI AW CDG DC D+SDE +C CGP PCA+ C+
Sbjct: 1095 CDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFL--CGPPKHPCANDTSVCLQ 1152
Query: 87 GRFRCNGFEDCPDGSDE----ENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNS 142
CNG +DCPDGSDE + C+ N CS HC + + +C Q N
Sbjct: 1153 PEKLCNGKKDCPDGSDEGYLCDECSLNNGGCSN---HC--SVVPGRGIVCSCPEGLQLNK 1207
Query: 143 DEESCE 148
D ++CE
Sbjct: 1208 DNKTCE 1213
Score = 80.5 bits (197), Expect = 2e-15
Identities = 43/119 (36%), Positives = 56/119 (47%), Gaps = 7/119 (5%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFP--CASGIHCIIGRFRCN 92
F+C+N C W CDG DC D SDE K C P+ P C + C+ CN
Sbjct: 3679 FLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLC-PSTRPHRCRNNRICLQSEQMCN 3737
Query: 93 GFEDCPDGSDEENC----TANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESC 147
G ++C D SDE++C T C + C N CI CD ++C D SDE+ C
Sbjct: 3738 GIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGC 3796
Score = 75.9 bits (185), Expect = 5e-14
Identities = 45/127 (35%), Positives = 60/127 (47%), Gaps = 6/127 (4%)
Query: 35 FMCSNGRCIPGA-WQCDGLPDCFDKSDEK----ECPKAKSKCGPTFFPCASGIHCIIGRF 89
F C++GRC+ WQCDG DC D SDE +C A+ C +FF C +G CI
Sbjct: 2850 FSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCNSSFFMCKNG-RCIPSGG 2908
Query: 90 RCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCES 149
C+ +DC DGSDE NC N L ++ + S+ C Q D ++C
Sbjct: 2909 LCDNKDDCGDGSDERNCHINECLSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVD 2968
Query: 150 SQEPGSG 156
E SG
Sbjct: 2969 IDECSSG 2975
Score = 70.9 bits (172), Expect = 2e-12
Identities = 44/122 (36%), Positives = 62/122 (50%), Gaps = 14/122 (11%)
Query: 36 MCSNGRC------IPGAWQCDGLPDCFD-KSDEKECPKAKSKCGPTFFPCASGIHCIIGR 88
M +NG C PG P F +D + C S C + F C + CI
Sbjct: 3278 MINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTC---LSNCTASQFRCKTD-KCIPFW 3333
Query: 89 FRCNGFEDCPDGSDE-ENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESC 147
++C+ +DC DGSDE ++C C R+ C GLC +FICDG+N+C DNSDE +C
Sbjct: 3334 WKCDTVDDCGDGSDEPDDCPE--FRCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNC 3391
Query: 148 ES 149
++
Sbjct: 3392 DT 3393
Score = 65.1 bits (157), Expect = 9e-11
Identities = 41/126 (32%), Positives = 57/126 (45%), Gaps = 6/126 (4%)
Query: 32 PGNFMCSNG-RCIPGAWQCDGLPDCFDKSDEK--ECPK-AKSKCGPTFFPCASGIHCIIG 87
PG F+C + C+ +W CDG PDC D SDE CP+ + KC C C+
Sbjct: 34 PGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCVHL 93
Query: 88 RFRCNGFEDCPDGSDEENCTANPLLCSTARYHCK-NGLCIDKSFICDGQNNCQDNSDEES 146
CNG DCPDG D E LL + + +C+ + S C ++ + D S
Sbjct: 94 SQLCNGVLDCPDGYD-EGVHCQELLSNCQQLNCQYKCTMVRNSTRCYCEDGFEITEDGRS 152
Query: 147 CESSQE 152
C+ E
Sbjct: 153 CKDQDE 158
Score = 60.8 bits (146), Expect = 2e-09
Identities = 40/133 (30%), Positives = 56/133 (42%), Gaps = 7/133 (5%)
Query: 24 NFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSD-----EKECPKAKSKCGP-TFFP 77
N TN C + + + G +G +C + D + C S C + F
Sbjct: 2458 NDTNSCELSPCALLNGGCHDLCLLTPNGRVNCSCRGDRILLEDNRCVTKNSSCNAYSEFE 2517
Query: 78 CASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNN 137
C +G CI + C+G C D SDE+ C C N CI +CDG+N+
Sbjct: 2518 CGNG-ECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGEND 2576
Query: 138 CQDNSDEESCESS 150
C DNSDE C+ S
Sbjct: 2577 CGDNSDELDCKVS 2589
Score = 52.0 bits (123), Expect = 8e-07
Identities = 38/130 (29%), Positives = 56/130 (43%), Gaps = 21/130 (16%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSK--CGPTFFPCASGIHCIIGRFRCN 92
F CSN +CIP QCD L DC D SDE+ C A ++ C PC +C + + +
Sbjct: 3767 FACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDAYC--NQIKTS 3824
Query: 93 GFEDCPDG----------SDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNS 142
F C G D C L+ T + C N ++ S+ C N Q+ +
Sbjct: 3825 VFCRCKPGFQRNMKNRQCEDLNEC----LVFGTCSHQCIN---VEGSYKCVCDQNFQERN 3877
Query: 143 DEESCESSQE 152
+ E S++
Sbjct: 3878 NTCIAEGSED 3887
Score = 50.8 bits (120), Expect = 2e-06
Identities = 40/121 (33%), Positives = 50/121 (41%), Gaps = 12/121 (9%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCN-- 92
FMC NGRCIP CD DC D SDE+ C C+ + ++C
Sbjct: 2896 FMCKNGRCIPSGGLCDNKDDCGDGSDERNC-HINECLSKKVSGCSQDCQDLPVSYKCKCW 2954
Query: 93 -GFEDCPDGS---DEENCTANPLLCSTA---RYHCKNGLCIDKSFI-CDGQNNCQDNSDE 144
GF+ DG D + C++ CS Y LC D I D N C+ SDE
Sbjct: 2955 PGFQLKDDGKTCVDIDECSSG-FPCSQQCINTYGTYKCLCTDGYEIQPDNPNGCKSLSDE 3013
Query: 145 E 145
E
Sbjct: 3014 E 3014
Score = 44.7 bits (104), Expect = 1e-04
Identities = 25/84 (29%), Positives = 34/84 (40%), Gaps = 16/84 (19%)
Query: 71 CGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEE----------NCTANPLLCSTARYHC 120
C P F C + C+ + C+G DCPD SDE C N + C
Sbjct: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIAC------L 85
Query: 121 KNGLCIDKSFICDGQNNCQDNSDE 144
C+ S +C+G +C D DE
Sbjct: 86 GTNKCVHLSQLCNGVLDCPDGYDE 109
>gi|148727288 low density lipoprotein receptor-related protein 6 [Homo
sapiens]
Length = 1613
Score = 110 bits (276), Expect = 1e-24
Identities = 57/124 (45%), Positives = 68/124 (54%), Gaps = 10/124 (8%)
Query: 32 PGNFMCSNGR--CIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRF 89
P F C G CIP AW+CDG +C D SDE CP C + F CASG CI G
Sbjct: 1251 PQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPV----CSESQFQCASG-QCIDGAL 1305
Query: 90 RCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCES 149
RCNG +C D SDE+NC +LC ++ C NG CI K CD +C D SDE C
Sbjct: 1306 RCNGDANCQDKSDEKNCE---VLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYP 1362
Query: 150 SQEP 153
++EP
Sbjct: 1363 TEEP 1366
Score = 82.0 bits (201), Expect = 7e-16
Identities = 40/90 (44%), Positives = 55/90 (61%), Gaps = 6/90 (6%)
Query: 60 DEKECPKAKSKCGPTFFPCASG-IHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARY 118
DE C + + C P F C +G I CI +RC+GF +C D SDE NC +CS +++
Sbjct: 1239 DELSCGEPPT-CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP----VCSESQF 1293
Query: 119 HCKNGLCIDKSFICDGQNNCQDNSDEESCE 148
C +G CID + C+G NCQD SDE++CE
Sbjct: 1294 QCASGQCIDGALRCNGDANCQDKSDEKNCE 1323
Score = 61.6 bits (148), Expect = 1e-09
Identities = 35/85 (41%), Positives = 48/85 (56%), Gaps = 8/85 (9%)
Query: 26 TNECNIP----GNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASG 81
++E N P F C++G+CI GA +C+G +C DKSDEK C + C F CA+G
Sbjct: 1280 SDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC---EVLCLIDQFRCANG 1336
Query: 82 IHCIIGRFRCNGFEDCPDGSDEENC 106
CI +C+ DC D SDE +C
Sbjct: 1337 -QCIGKHKKCDHNVDCSDKSDELDC 1360
>gi|65301164 very low density lipoprotein receptor isoform b [Homo
sapiens]
Length = 845
Score = 108 bits (271), Expect = 5e-24
Identities = 50/121 (41%), Positives = 69/121 (57%), Gaps = 15/121 (12%)
Query: 34 NFMCSNGRCIPGAWQCDGLPDCFDKSDE-------KECPKAKSKCGPTFFPCASGIHCII 86
+F+C+NG+C+P W+CDG PDC D SDE + C + CG A CI
Sbjct: 76 DFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCG------AHSTQCIP 129
Query: 87 GRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEES 146
+RC+G DC G DEENC + CS + C +G CI ++F+C+GQ++C D SDE
Sbjct: 130 VSWRCDGENDCDSGEDEENC--GNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELD 187
Query: 147 C 147
C
Sbjct: 188 C 188
Score = 105 bits (263), Expect = 5e-23
Identities = 58/149 (38%), Positives = 74/149 (49%), Gaps = 10/149 (6%)
Query: 1 MWLLGPLCLLLSSAAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSD 60
+WLL LC A G +C P F C+NGRCI W+CDG DC D SD
Sbjct: 9 LWLLLALCW----APRESGATGTGRKAKCE-PSQFQCTNGRCITLLWKCDGDEDCVDGSD 63
Query: 61 EKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHC 120
EK C K C + F C +G C+ R++C+G DC DGSDE + C C
Sbjct: 64 EKNC--VKKTCAESDFVCNNG-QCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC 120
Query: 121 --KNGLCIDKSFICDGQNNCQDNSDEESC 147
+ CI S+ CDG+N+C DEE+C
Sbjct: 121 GAHSTQCIPVSWRCDGENDCDSGEDEENC 149
Score = 103 bits (257), Expect = 2e-22
Identities = 49/108 (45%), Positives = 61/108 (56%), Gaps = 3/108 (2%)
Query: 37 CSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFED 96
C +G CI W+CDG PDC D SDE CP C P F C G CI G +CNG D
Sbjct: 246 CGSGECIHKKWRCDGDPDCKDGSDEVNCPSRT--CRPDQFECEDG-SCIHGSRQCNGIRD 302
Query: 97 CPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDE 144
C DGSDE NC ++ C++G CID S +C+ + +C+D SDE
Sbjct: 303 CVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDE 350
Score = 98.6 bits (244), Expect = 7e-21
Identities = 50/120 (41%), Positives = 69/120 (57%), Gaps = 8/120 (6%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDE--KEC---PKAKSKCGPTFFPCASGIHCIIGRF 89
F CS CIP +W CD DC D+SDE ++C P +KC + C SG CI ++
Sbjct: 198 FQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSG-ECIHKKW 256
Query: 90 RCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCES 149
RC+G DC DGSDE NC + C ++ C++G CI S C+G +C D SDE +C++
Sbjct: 257 RCDGDPDCKDGSDEVNCPSRT--CRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKN 314
Score = 92.4 bits (228), Expect = 5e-19
Identities = 50/123 (40%), Positives = 66/123 (53%), Gaps = 8/123 (6%)
Query: 32 PGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRC 91
P F CS+GRCI + C+G DC D SDE +C A CG F C++ CI + C
Sbjct: 156 PDEFTCSSGRCISRNFVCNGQDDCSDGSDELDC--APPTCGAHEFQCSTS-SCIPISWVC 212
Query: 92 NGFEDCPDGSDE--ENCTANPLL---CSTARYHCKNGLCIDKSFICDGQNNCQDNSDEES 146
+ DC D SDE E C P++ C + C +G CI K + CDG +C+D SDE +
Sbjct: 213 DDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVN 272
Query: 147 CES 149
C S
Sbjct: 273 CPS 275
Score = 67.4 bits (163), Expect = 2e-11
Identities = 47/133 (35%), Positives = 61/133 (45%), Gaps = 18/133 (13%)
Query: 32 PGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRC 91
P F C +G CI G+ QC+G+ DC D SDE C GP F C SG CI C
Sbjct: 280 PDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSG-ECIDISKVC 338
Query: 92 NGFEDCPDGSDE--ENCTANPLLCSTARYHCKNGLC--IDKSFICDGQNNCQ---DNSDE 144
N +DC D SDE + C N L + NG C I K + + +C + D
Sbjct: 339 NQEQDCRDWSDEPLKECHINECLVN-------NGGCSHICKDLVIGYECDCAAGFELIDR 391
Query: 145 ESC---ESSQEPG 154
++C + Q PG
Sbjct: 392 KTCGDIDECQNPG 404
Score = 41.6 bits (96), Expect = 0.001
Identities = 34/104 (32%), Positives = 48/104 (46%), Gaps = 10/104 (9%)
Query: 27 NECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDE--KECPKAKSKCGPTFFPCASGIHC 84
N+C PG F C +G CI + C+ DC D SDE KEC ++C C+
Sbjct: 316 NQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKEC--HINECLVNNGGCSHICKD 373
Query: 85 IIGRFRCN---GFE--DCPDGSDEENCTANPLLCSTARYHCKNG 123
++ + C+ GFE D D + C NP +CS + K G
Sbjct: 374 LVIGYECDCAAGFELIDRKTCGDIDEC-QNPGICSQICINLKGG 416
>gi|65301167 very low density lipoprotein receptor isoform a [Homo
sapiens]
Length = 873
Score = 108 bits (271), Expect = 5e-24
Identities = 50/121 (41%), Positives = 69/121 (57%), Gaps = 15/121 (12%)
Query: 34 NFMCSNGRCIPGAWQCDGLPDCFDKSDE-------KECPKAKSKCGPTFFPCASGIHCII 86
+F+C+NG+C+P W+CDG PDC D SDE + C + CG A CI
Sbjct: 76 DFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCG------AHSTQCIP 129
Query: 87 GRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEES 146
+RC+G DC G DEENC + CS + C +G CI ++F+C+GQ++C D SDE
Sbjct: 130 VSWRCDGENDCDSGEDEENC--GNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELD 187
Query: 147 C 147
C
Sbjct: 188 C 188
Score = 105 bits (263), Expect = 5e-23
Identities = 58/149 (38%), Positives = 74/149 (49%), Gaps = 10/149 (6%)
Query: 1 MWLLGPLCLLLSSAAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSD 60
+WLL LC A G +C P F C+NGRCI W+CDG DC D SD
Sbjct: 9 LWLLLALCW----APRESGATGTGRKAKCE-PSQFQCTNGRCITLLWKCDGDEDCVDGSD 63
Query: 61 EKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHC 120
EK C K C + F C +G C+ R++C+G DC DGSDE + C C
Sbjct: 64 EKNC--VKKTCAESDFVCNNG-QCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC 120
Query: 121 --KNGLCIDKSFICDGQNNCQDNSDEESC 147
+ CI S+ CDG+N+C DEE+C
Sbjct: 121 GAHSTQCIPVSWRCDGENDCDSGEDEENC 149
Score = 103 bits (257), Expect = 2e-22
Identities = 49/108 (45%), Positives = 61/108 (56%), Gaps = 3/108 (2%)
Query: 37 CSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFED 96
C +G CI W+CDG PDC D SDE CP C P F C G CI G +CNG D
Sbjct: 246 CGSGECIHKKWRCDGDPDCKDGSDEVNCPSRT--CRPDQFECEDG-SCIHGSRQCNGIRD 302
Query: 97 CPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDE 144
C DGSDE NC ++ C++G CID S +C+ + +C+D SDE
Sbjct: 303 CVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDE 350
Score = 98.6 bits (244), Expect = 7e-21
Identities = 50/120 (41%), Positives = 69/120 (57%), Gaps = 8/120 (6%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDE--KEC---PKAKSKCGPTFFPCASGIHCIIGRF 89
F CS CIP +W CD DC D+SDE ++C P +KC + C SG CI ++
Sbjct: 198 FQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSG-ECIHKKW 256
Query: 90 RCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCES 149
RC+G DC DGSDE NC + C ++ C++G CI S C+G +C D SDE +C++
Sbjct: 257 RCDGDPDCKDGSDEVNCPSRT--CRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKN 314
Score = 92.4 bits (228), Expect = 5e-19
Identities = 50/123 (40%), Positives = 66/123 (53%), Gaps = 8/123 (6%)
Query: 32 PGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRC 91
P F CS+GRCI + C+G DC D SDE +C A CG F C++ CI + C
Sbjct: 156 PDEFTCSSGRCISRNFVCNGQDDCSDGSDELDC--APPTCGAHEFQCSTS-SCIPISWVC 212
Query: 92 NGFEDCPDGSDE--ENCTANPLL---CSTARYHCKNGLCIDKSFICDGQNNCQDNSDEES 146
+ DC D SDE E C P++ C + C +G CI K + CDG +C+D SDE +
Sbjct: 213 DDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVN 272
Query: 147 CES 149
C S
Sbjct: 273 CPS 275
Score = 67.4 bits (163), Expect = 2e-11
Identities = 47/133 (35%), Positives = 61/133 (45%), Gaps = 18/133 (13%)
Query: 32 PGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRC 91
P F C +G CI G+ QC+G+ DC D SDE C GP F C SG CI C
Sbjct: 280 PDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSG-ECIDISKVC 338
Query: 92 NGFEDCPDGSDE--ENCTANPLLCSTARYHCKNGLC--IDKSFICDGQNNCQ---DNSDE 144
N +DC D SDE + C N L + NG C I K + + +C + D
Sbjct: 339 NQEQDCRDWSDEPLKECHINECLVN-------NGGCSHICKDLVIGYECDCAAGFELIDR 391
Query: 145 ESC---ESSQEPG 154
++C + Q PG
Sbjct: 392 KTCGDIDECQNPG 404
Score = 41.6 bits (96), Expect = 0.001
Identities = 34/104 (32%), Positives = 48/104 (46%), Gaps = 10/104 (9%)
Query: 27 NECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDE--KECPKAKSKCGPTFFPCASGIHC 84
N+C PG F C +G CI + C+ DC D SDE KEC ++C C+
Sbjct: 316 NQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKEC--HINECLVNNGGCSHICKD 373
Query: 85 IIGRFRCN---GFE--DCPDGSDEENCTANPLLCSTARYHCKNG 123
++ + C+ GFE D D + C NP +CS + K G
Sbjct: 374 LVIGYECDCAAGFELIDRKTCGDIDEC-QNPGICSQICINLKGG 416
>gi|119709832 low density lipoprotein receptor-related protein 5 [Homo
sapiens]
Length = 1615
Score = 108 bits (270), Expect = 7e-24
Identities = 54/124 (43%), Positives = 70/124 (56%), Gaps = 10/124 (8%)
Query: 32 PGNFMCSNGR--CIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRF 89
P F C+ G CIPGAW+CDG P+C D+SDE+ CP C FPCA G C+ R
Sbjct: 1261 PDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP----VCSAAQFPCARG-QCVDLRL 1315
Query: 90 RCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCES 149
RC+G DC D SDE +C A +C ++ C +G C+ CD +C D SDE CE
Sbjct: 1316 RCDGEADCQDRSDEADCDA---ICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEI 1372
Query: 150 SQEP 153
++ P
Sbjct: 1373 TKPP 1376
Score = 43.5 bits (101), Expect = 3e-04
Identities = 17/38 (44%), Positives = 22/38 (57%)
Query: 31 IPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAK 68
+P F C++G+C+ QCD PDC D SDE C K
Sbjct: 1337 LPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITK 1374
>gi|4507157 sortilin-related receptor containing LDLR class A repeats
preproprotein [Homo sapiens]
Length = 2214
Score = 106 bits (264), Expect = 3e-23
Identities = 52/125 (41%), Positives = 67/125 (53%), Gaps = 13/125 (10%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKEC--PKAKSKCGPTF-FPCASGIHCIIGRFRC 91
F C NG CI W+CDG+ DC D SDE C P C F F C +G HCI R++C
Sbjct: 1330 FQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENG-HCIPNRWKC 1388
Query: 92 NGFEDCPDGSDEENC---------TANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNS 142
+ DC D SDE++C T P C Y C +G C+ +++CDG +C D S
Sbjct: 1389 DRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGS 1448
Query: 143 DEESC 147
DEE+C
Sbjct: 1449 DEEAC 1453
Score = 103 bits (256), Expect = 3e-22
Identities = 52/126 (41%), Positives = 72/126 (57%), Gaps = 6/126 (4%)
Query: 26 TNECNIPGNFMCS-NGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHC 84
T C++ F C +G CIP +++CD DC D SDE C +C + C+SG+ C
Sbjct: 1114 TTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEM--HQCRSDEYNCSSGM-C 1170
Query: 85 IIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDE 144
I + C+G DC D SDE NCTA C + + C+NG CI + + CDG +CQD SDE
Sbjct: 1171 IRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDE 1230
Query: 145 E--SCE 148
+ +CE
Sbjct: 1231 DPVNCE 1236
Score = 102 bits (254), Expect = 5e-22
Identities = 52/140 (37%), Positives = 72/140 (51%), Gaps = 5/140 (3%)
Query: 10 LLSSAAESQLLPGNNFTNECN--IPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKA 67
L+ + L N E N + + CSNG CI W CD DC D SDE+ CP
Sbjct: 1056 LMCDCPQGYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTT 1115
Query: 68 KSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCID 127
T F C CI ++C+ +DC D SDE +C + C + Y+C +G+CI
Sbjct: 1116 ICDL-DTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQ--CRSDEYNCSSGMCIR 1172
Query: 128 KSFICDGQNNCQDNSDEESC 147
S++CDG N+C+D SDE +C
Sbjct: 1173 SSWVCDGDNDCRDWSDEANC 1192
Score = 100 bits (248), Expect = 2e-21
Identities = 53/145 (36%), Positives = 73/145 (50%), Gaps = 13/145 (8%)
Query: 16 ESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKS------ 69
+S +LP + +P + CS+G C+ W CDG DC D SDE+ CP +
Sbjct: 1405 DSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAAST 1464
Query: 70 -----KCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENC-TANPLLCSTARYHCKNG 123
+C F C CI RC+G +DC DG DE NC T + L C + + C++G
Sbjct: 1465 PTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDG 1524
Query: 124 -LCIDKSFICDGQNNCQDNSDEESC 147
CI S CDG +C D SDE++C
Sbjct: 1525 EACIVLSERCDGFLDCSDESDEKAC 1549
Score = 97.1 bits (240), Expect = 2e-20
Identities = 51/136 (37%), Positives = 70/136 (51%), Gaps = 12/136 (8%)
Query: 24 NFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIH 83
N +CN F C NG CIP + CDGL DC D SDE+ C + F C +
Sbjct: 1234 NCEKKCN---GFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHF--MDFVCKNRQQ 1288
Query: 84 CIIGRFRCNGFEDCPDGSDEE----NCTANP---LLCSTARYHCKNGLCIDKSFICDGQN 136
C+ C+G C DGSDE+ C+ +P +C + C+NG+CI + CDG +
Sbjct: 1289 CLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMD 1348
Query: 137 NCQDNSDEESCESSQE 152
+C D SDE +CE+ E
Sbjct: 1349 DCGDYSDEANCENPTE 1364
Score = 96.3 bits (238), Expect = 4e-20
Identities = 53/143 (37%), Positives = 68/143 (47%), Gaps = 28/143 (19%)
Query: 29 CNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKEC---------PKAKSKCGPTFFPCA 79
C+ F C NG CIP W+CD DC D SDEK+C S C P ++ C+
Sbjct: 1368 CSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCS 1427
Query: 80 SGIHCIIGRFRCNGFEDCPDGSDEENCTANPLL--------------CSTARYHC-KNGL 124
SG C++ + C+G+ DC DGSDEE C PLL C + C +
Sbjct: 1428 SGT-CVMDTWVCDGYRDCADGSDEEAC---PLLANVTAASTPTQLGRCDRFEFECHQPKT 1483
Query: 125 CIDKSFICDGQNNCQDNSDEESC 147
CI CDG +CQD DE +C
Sbjct: 1484 CIPNWKRCDGHQDCQDGRDEANC 1506
Score = 63.5 bits (153), Expect = 3e-10
Identities = 37/102 (36%), Positives = 50/102 (49%), Gaps = 8/102 (7%)
Query: 7 LCLLLSSAAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPK 66
L + +++ +QL + F EC+ P CIP +CDG DC D DE CP
Sbjct: 1456 LANVTAASTPTQLGRCDRFEFECHQPKT-------CIPNWKRCDGHQDCQDGRDEANCPT 1508
Query: 67 AKS-KCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCT 107
+ C F C G CI+ RC+GF DC D SDE+ C+
Sbjct: 1509 HSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACS 1550
Score = 62.4 bits (150), Expect = 6e-10
Identities = 44/135 (32%), Positives = 66/135 (48%), Gaps = 11/135 (8%)
Query: 20 LPGNNFTNECNIPGNFMCSNGRCIP-GAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPC 78
LP N + C P + S +P G CD P + + C K ++ C + C
Sbjct: 1031 LPKANNSRSCRCPEDVSSS---VLPSGDLMCD-CPQGYQLKNNT-CVKEENTCLRNQYRC 1085
Query: 79 ASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCST-ARYHCK-NGLCIDKSFICDGQN 136
++G +CI + C+ DC D SDE NC +C ++ C+ +G CI S+ CD ++
Sbjct: 1086 SNG-NCINSIWWCDFDNDCGDMSDERNCPTT--ICDLDTQFRCQESGTCIPLSYKCDLED 1142
Query: 137 NCQDNSDEESCESSQ 151
+C DNSDE CE Q
Sbjct: 1143 DCGDNSDESHCEMHQ 1157
>gi|29244926 corin [Homo sapiens]
Length = 1042
Score = 106 bits (264), Expect = 3e-23
Identities = 50/119 (42%), Positives = 67/119 (56%), Gaps = 10/119 (8%)
Query: 29 CNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGR 88
C NF+C++G CIPG QC+G DC D SDE C C F C +G C+
Sbjct: 269 CGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHC-----NCSENLFHCHTG-KCLNYS 322
Query: 89 FRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESC 147
C+G++DC D SDE+NC NP T + C +G CI ++CDG ++C D SDE +C
Sbjct: 323 LVCDGYDDCGDLSDEQNCDCNP----TTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNC 377
Score = 96.3 bits (238), Expect = 4e-20
Identities = 47/136 (34%), Positives = 72/136 (52%), Gaps = 10/136 (7%)
Query: 12 SSAAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKC 71
+S ++ L+P + + EC+ P +F C +G+C+ + +CDG DC D SDE+ C +
Sbjct: 564 NSDNQTCLMP-DEYVEECS-PSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKER-- 619
Query: 72 GPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFI 131
+ C S C+ C+GF DCPD DE+NC+ C C N C+ +
Sbjct: 620 --DLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCS----FCQDDELECANHACVSRDLW 673
Query: 132 CDGQNNCQDNSDEESC 147
CDG+ +C D+SDE C
Sbjct: 674 CDGEADCSDSSDEWDC 689
Score = 91.3 bits (225), Expect = 1e-18
Identities = 52/144 (36%), Positives = 67/144 (46%), Gaps = 9/144 (6%)
Query: 28 ECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIG 87
+CN C +GRCI W CDG DC DKSDE C S C +G CI
Sbjct: 341 DCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNC----SCHSQGLVECRNG-QCIPS 395
Query: 88 RFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESC 147
F+C+G EDC DGSDEENC+ C C C+D C G + C N+ +C
Sbjct: 396 TFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDS---CGGSSLCDPNNSLNNC 452
Query: 148 ESSQEPGSGQVFVTSENQLVYYPS 171
S EP + ++ + YP+
Sbjct: 453 -SQCEPITLELCMNLPYNSTSYPN 475
Score = 80.1 bits (196), Expect = 3e-15
Identities = 35/73 (47%), Positives = 48/73 (65%), Gaps = 6/73 (8%)
Query: 76 FPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQ 135
F CASGI CI G+ +CNG+ DC D SDE +C CS +HC G C++ S +CDG
Sbjct: 275 FLCASGI-CIPGKLQCNGYNDCDDWSDEAHCN-----CSENLFHCHTGKCLNYSLVCDGY 328
Query: 136 NNCQDNSDEESCE 148
++C D SDE++C+
Sbjct: 329 DDCGDLSDEQNCD 341
Score = 67.0 bits (162), Expect = 2e-11
Identities = 38/113 (33%), Positives = 54/113 (47%), Gaps = 11/113 (9%)
Query: 44 PGAWQCDGLPDCFDKSDEKEC---PKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDG 100
P C P+ + SD + C + +C P+ F C SG C++ RC+G DC D
Sbjct: 552 PEDTDCSQFPE--ENSDNQTCLMPDEYVEECSPSHFKCRSG-QCVLASRRCDGQADCDDD 608
Query: 101 SDEENCTANPLLCSTARYHC-KNGLCIDKSFICDGQNNCQDNSDEESCESSQE 152
SDEENC + C N C+ + ICDG +C D DE++C Q+
Sbjct: 609 SDEENCGCK----ERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSFCQD 657
Score = 41.2 bits (95), Expect = 0.001
Identities = 22/70 (31%), Positives = 33/70 (47%), Gaps = 8/70 (11%)
Query: 90 RCNGFEDCPDGSDEENCTANP-------LLCSTAR-YHCKNGLCIDKSFICDGQNNCQDN 141
RC+ F + + S+ +P LLC + C +G+CI C+G N+C D
Sbjct: 239 RCSQFRNQTESSNVSRICFSPQQENGKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDW 298
Query: 142 SDEESCESSQ 151
SDE C S+
Sbjct: 299 SDEAHCNCSE 308
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 103 bits (257), Expect = 2e-22
Identities = 58/140 (41%), Positives = 73/140 (52%), Gaps = 6/140 (4%)
Query: 15 AESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPT 74
A LLPG+ C P C NG CIP + CDG DC D SDE +C C P
Sbjct: 271 APQPLLPGSVRPLPCG-PQEAACRNGHCIPRDYLCDGQEDCEDGSDELDC-GPPPPCEPN 328
Query: 75 FFPCASGIHCIIGRFRCNGFEDCPDGSDEENC-TANP-LLCSTARYHC-KNGLCIDKSFI 131
FPC +G HC + +RC+G DC D +DE NC T P +C ++ C +CI SF
Sbjct: 329 EFPCGNG-HCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVSTNMCIPASFH 387
Query: 132 CDGQNNCQDNSDEESCESSQ 151
CD +++C D SDE C Q
Sbjct: 388 CDEESDCPDRSDEFGCMPPQ 407
Score = 75.9 bits (185), Expect = 5e-14
Identities = 49/162 (30%), Positives = 67/162 (41%), Gaps = 47/162 (29%)
Query: 35 FMC-SNGRCIPGAWQCDGLPDCFDKSDEKEC---------------------PKAKS--- 69
F C S C+ ++CD PDC D SDE C P+ ++
Sbjct: 204 FACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRPETTIM 263
Query: 70 --------------------KCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTAN 109
CGP C +G HCI + C+G EDC DGSDE +C
Sbjct: 264 RQPPVTHAPQPLLPGSVRPLPCGPQEAACRNG-HCIPRDYLCDGQEDCEDGSDELDC-GP 321
Query: 110 PLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQ 151
P C + C NG C K + CDG +C+D +DE +C + +
Sbjct: 322 PPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKR 363
Score = 58.2 bits (139), Expect = 1e-08
Identities = 34/127 (26%), Positives = 45/127 (35%), Gaps = 44/127 (34%)
Query: 65 PKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENC------------------ 106
P+ C F C S C+ +RC+ DC D SDE NC
Sbjct: 193 PQFPRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETT 252
Query: 107 --------------------------TANPLLCSTARYHCKNGLCIDKSFICDGQNNCQD 140
+ PL C C+NG CI + ++CDGQ +C+D
Sbjct: 253 SLPPRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCED 312
Query: 141 NSDEESC 147
SDE C
Sbjct: 313 GSDELDC 319
Score = 33.1 bits (74), Expect = 0.37
Identities = 14/40 (35%), Positives = 23/40 (57%), Gaps = 1/40 (2%)
Query: 110 PLLCSTARYHCKN-GLCIDKSFICDGQNNCQDNSDEESCE 148
P C+ A + C + C+ + CD + +C+D SDE +CE
Sbjct: 196 PRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCE 235
>gi|222831592 transmembrane protease, serine 7 [Homo sapiens]
Length = 717
Score = 101 bits (252), Expect = 9e-22
Identities = 51/129 (39%), Positives = 72/129 (55%), Gaps = 10/129 (7%)
Query: 24 NFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIH 83
N + C + G+F CS+G C+P A +CDG+ DCFD+SDE C + C + F
Sbjct: 353 NISQPCPV-GSFRCSSGLCVPQAQRCDGVNDCFDESDELFCVSPQPACNTSSFRQH---- 407
Query: 84 CIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDK-SFICDGQNNCQDNS 142
G C+GF DC +G DE+NCT + + C+ + C N +C K + CDG +C D S
Sbjct: 408 ---GPLICDGFRDCENGRDEQNCTQS-IPCNNRTFKCGNDICFRKQNAKCDGTVDCPDGS 463
Query: 143 DEESCESSQ 151
DEE C S+
Sbjct: 464 DEEGCTCSR 472
Score = 35.4 bits (80), Expect = 0.075
Identities = 25/71 (35%), Positives = 36/71 (50%), Gaps = 16/71 (22%)
Query: 17 SQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFF 76
+Q +P NN T +C GN +C + +CDG DC D SDE+ C ++S
Sbjct: 428 TQSIPCNNRTFKC---GNDICFRKQNA----KCDGTVDCPDGSDEEGCTCSRS------- 473
Query: 77 PCASGIHCIIG 87
+S +H IIG
Sbjct: 474 --SSALHRIIG 482
>gi|11415040 matriptase [Homo sapiens]
Length = 855
Score = 100 bits (249), Expect = 2e-21
Identities = 50/122 (40%), Positives = 67/122 (54%), Gaps = 8/122 (6%)
Query: 29 CNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGR 88
C+ F C N C P W CD + DC D SDE+ C C F C++G C+
Sbjct: 488 CDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGC-----SCPAQTFRCSNG-KCLSKS 541
Query: 89 FRCNGFEDCPDGSDEENC-TANPLLCSTARYHCKNGLCIDK-SFICDGQNNCQDNSDEES 146
+CNG +DC DGSDE +C N + C+ Y C NGLC+ K + CDG+ +C D SDE+
Sbjct: 542 QQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKD 601
Query: 147 CE 148
C+
Sbjct: 602 CD 603
Score = 74.3 bits (181), Expect = 1e-13
Identities = 36/86 (41%), Positives = 48/86 (55%), Gaps = 2/86 (2%)
Query: 23 NNFTNECNIPGN-FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAK-SKCGPTFFPCAS 80
N+ C+ P F CSNG+C+ + QC+G DC D SDE CPK C + C +
Sbjct: 517 NSDEQGCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLN 576
Query: 81 GIHCIIGRFRCNGFEDCPDGSDEENC 106
G+ G C+G EDC DGSDE++C
Sbjct: 577 GLCLSKGNPECDGKEDCSDGSDEKDC 602
>gi|4504975 low density lipoprotein receptor precursor [Homo
sapiens]
Length = 860
Score = 99.4 bits (246), Expect = 4e-21
Identities = 46/114 (40%), Positives = 61/114 (53%), Gaps = 3/114 (2%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIH-CIIGRFRCNG 93
F C +G+CI W CDG +C D SDE + C F C ++ CI +RC+G
Sbjct: 32 FQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDG 91
Query: 94 FEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESC 147
DC +GSDE+ C P CS + C +G CI + F+CD +C D SDE SC
Sbjct: 92 QVDCDNGSDEQGCP--PKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASC 143
Score = 95.1 bits (235), Expect = 8e-20
Identities = 51/124 (41%), Positives = 62/124 (50%), Gaps = 11/124 (8%)
Query: 32 PGNFMCSNGRCIPGAWQCDGLPDCFDKSDE--KEC------PKAKSKCGPTFFPCASGIH 83
P +F C++ CIP W CD PDC D SDE + C S C F C SG
Sbjct: 150 PASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSG-E 208
Query: 84 CIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSD 143
CI +RC+G DC D SDEENC C + C +G CI S CD + +C+D SD
Sbjct: 209 CIHSSWRCDGGPDCKDKSDEENCAV--ATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSD 266
Query: 144 EESC 147
E C
Sbjct: 267 EVGC 270
Score = 94.4 bits (233), Expect = 1e-19
Identities = 50/121 (41%), Positives = 63/121 (52%), Gaps = 11/121 (9%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGF 94
F C +G+CI + CD DC D SDE CP CGP F C S CI + C+
Sbjct: 114 FRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLT--CGPASFQCNSST-CIPQLWACDND 170
Query: 95 EDCPDGSDE--ENCTANPLL------CSTARYHCKNGLCIDKSFICDGQNNCQDNSDEES 146
DC DGSDE + C + CS +HC +G CI S+ CDG +C+D SDEE+
Sbjct: 171 PDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEEN 230
Query: 147 C 147
C
Sbjct: 231 C 231
Score = 92.4 bits (228), Expect = 5e-19
Identities = 46/110 (41%), Positives = 62/110 (56%), Gaps = 3/110 (2%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGF 94
F C +G CI +W+CDG PDC DKSDE+ C A + C P F C+ G +CI G +C+
Sbjct: 202 FHCLSGECIHSSWRCDGGPDCKDKSDEENC--AVATCRPDEFQCSDG-NCIHGSRQCDRE 258
Query: 95 EDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDE 144
DC D SDE C L ++ C +G CI +C+ +C+D SDE
Sbjct: 259 YDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDE 308
Score = 65.1 bits (157), Expect = 9e-11
Identities = 47/118 (39%), Positives = 53/118 (44%), Gaps = 10/118 (8%)
Query: 32 PGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRC 91
P F CS+G CI G+ QCD DC D SDE C GP F C SG CI C
Sbjct: 238 PDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSG-ECITLDKVC 296
Query: 92 NGFEDCPDGSDE--ENCTANPLLCSTAR-YHCKNGLCIDKSFIC-DG-----QNNCQD 140
N DC D SDE + C N L + H N L I +C DG Q C+D
Sbjct: 297 NMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCED 354
Score = 41.6 bits (96), Expect = 0.001
Identities = 17/39 (43%), Positives = 23/39 (58%), Gaps = 2/39 (5%)
Query: 113 CSTARYHCKNGLCIDKSFICDGQNNCQDNSDE--ESCES 149
C + C++G CI ++CDG CQD SDE E+C S
Sbjct: 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLS 65
Score = 36.6 bits (83), Expect = 0.034
Identities = 28/113 (24%), Positives = 38/113 (33%), Gaps = 16/113 (14%)
Query: 29 CNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDE-------KECPKAKSKCGPTFFPCASG 81
C P F C +G CI C+ DC D SDE EC C G
Sbjct: 276 CEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIG 335
Query: 82 IHC-------IIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCID 127
C ++ + RC ++C D N L + C+ G +D
Sbjct: 336 YECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVN--LEGGYKCQCEEGFQLD 386
>gi|134031945 SCO-spondin [Homo sapiens]
Length = 5147
Score = 95.9 bits (237), Expect = 5e-20
Identities = 48/116 (41%), Positives = 56/116 (48%), Gaps = 12/116 (10%)
Query: 32 PGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRC 91
P F C +G C P W+CD DC D SDE+ C C P PCA G HC+ C
Sbjct: 1567 PFEFRCGSGECTPRGWRCDQEEDCADGSDERGCG---GPCAPHHAPCARGPHCVSPEQLC 1623
Query: 92 NGFEDCPDGSDE--ENCTANPLLCSTAR-------YHCKNGLCIDKSFICDGQNNC 138
+G CPDGSDE + C P L R Y C NG CI +CDGQ +C
Sbjct: 1624 DGVRQCPDGSDEGPDACGGLPALGGPNRTGLPCPEYTCPNGTCIGFQLVCDGQPDC 1679
Score = 88.2 bits (217), Expect = 1e-17
Identities = 45/116 (38%), Positives = 60/116 (51%), Gaps = 9/116 (7%)
Query: 33 GNFMCS-NGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRC 91
G +C NG C+P W CD DC D SDE+ C A CG C+SG HC+ C
Sbjct: 1379 GEALCQENGHCVPHGWLCDNQDDCGDGSDEEGC--AAPGCGEGQMTCSSG-HCLPLALLC 1435
Query: 92 NGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESC 147
+ +DC DG+DE + C C +G C+ + +CDG +C D +DEESC
Sbjct: 1436 DRQDDCGDGTDEPSYP-----CPQGLLACADGRCLPPALLCDGHPDCLDAADEESC 1486
Score = 80.1 bits (196), Expect = 3e-15
Identities = 53/175 (30%), Positives = 76/175 (43%), Gaps = 38/175 (21%)
Query: 8 CLLLSSAAESQLLPGNNFTNECNIP---GNFMCSNGRCIPGAWQCDGLPDCFDKSDEKEC 64
CL L+ + Q G+ T+E + P G C++GRC+P A CDG PDC D +DE+ C
Sbjct: 1428 CLPLALLCDRQDDCGDG-TDEPSYPCPQGLLACADGRCLPPALLCDGHPDCLDAADEESC 1486
Query: 65 PKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEE-------------------- 104
+ C P C G C+ C+G DCPDG+DE
Sbjct: 1487 -LGQVTCVPGEVSCVDGT-CLGAIQLCDGVWDCPDGADEGPGHCPLPSLPTPPASTLPGP 1544
Query: 105 -----NCTANPLL-------CSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESC 147
+ ++PL C + C +G C + + CD + +C D SDE C
Sbjct: 1545 SPGSLDTASSPLASASPAPPCGPFEFRCGSGECTPRGWRCDQEEDCADGSDERGC 1599
Score = 77.4 bits (189), Expect = 2e-14
Identities = 40/112 (35%), Positives = 53/112 (47%), Gaps = 7/112 (6%)
Query: 33 GNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCN 92
G CS+G C+P A CD DC D +DE P C CA G C+ C+
Sbjct: 1419 GQMTCSSGHCLPLALLCDRQDDCGDGTDEPSYP-----CPQGLLACADG-RCLPPALLCD 1472
Query: 93 GFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDE 144
G DC D +DEE+C + C C +G C+ +CDG +C D +DE
Sbjct: 1473 GHPDCLDAADEESCLGQ-VTCVPGEVSCVDGTCLGAIQLCDGVWDCPDGADE 1523
Score = 72.4 bits (176), Expect = 6e-13
Identities = 38/118 (32%), Positives = 53/118 (44%), Gaps = 13/118 (11%)
Query: 32 PGNFM---CSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGR 88
PG+ + C N C G W C G D C + C C HC+
Sbjct: 1342 PGSVLQKDCGNCTCQEGQWHCGG--------DGGHCEELVPACAEGEALCQENGHCVPHG 1393
Query: 89 FRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEES 146
+ C+ +DC DGSDEE C A C + C +G C+ + +CD Q++C D +DE S
Sbjct: 1394 WLCDNQDDCGDGSDEEGCAAPG--CGEGQMTCSSGHCLPLALLCDRQDDCGDGTDEPS 1449
Score = 69.7 bits (169), Expect = 4e-12
Identities = 46/147 (31%), Positives = 56/147 (38%), Gaps = 37/147 (25%)
Query: 31 IPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEK--ECP----------------------- 65
+PG C +G C+ CDG+ DC D +DE CP
Sbjct: 1493 VPGEVSCVDGTCLGAIQLCDGVWDCPDGADEGPGHCPLPSLPTPPASTLPGPSPGSLDTA 1552
Query: 66 -------KAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARY 118
CGP F C SG C +RC+ EDC DGSDE C C+
Sbjct: 1553 SSPLASASPAPPCGPFEFRCGSG-ECTPRGWRCDQEEDCADGSDERGCGGP---CAPHHA 1608
Query: 119 HCKNGL-CIDKSFICDGQNNCQDNSDE 144
C G C+ +CDG C D SDE
Sbjct: 1609 PCARGPHCVSPEQLCDGVRQCPDGSDE 1635
Score = 55.8 bits (133), Expect = 5e-08
Identities = 36/127 (28%), Positives = 49/127 (38%), Gaps = 34/127 (26%)
Query: 12 SSAAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKEC------- 64
++ A + PG +C PG C C+ A CDG DC D SDE+ C
Sbjct: 2374 ATPAGQSVAPGPFPPVQCG-PGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMW 2432
Query: 65 -------------------------PKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPD 99
P +++ C P+ C SG C+ RC+ DC D
Sbjct: 2433 LPSLPALWAASTVPFMMPTMALPGLPASRALCSPSQLSCGSG-ECLSAERRCDLRPDCQD 2491
Query: 100 GSDEENC 106
GSDE+ C
Sbjct: 2492 GSDEDGC 2498
Score = 39.7 bits (91), Expect = 0.004
Identities = 20/42 (47%), Positives = 24/42 (57%), Gaps = 3/42 (7%)
Query: 78 CASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYH 119
CASG C++ C+G DC DGSDEE C P T R+H
Sbjct: 2241 CASG-ECVLRGGPCDGVLDCEDGSDEEGCVLLPE--GTGRFH 2279
Score = 39.7 bits (91), Expect = 0.004
Identities = 20/76 (26%), Positives = 37/76 (48%), Gaps = 14/76 (18%)
Query: 110 PLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQVFVTSENQLVYY 169
P+ C + C+ C++++ +CDG+ +C D SDE C + N L++
Sbjct: 2388 PVQCGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHC--------------ARNLLMWL 2433
Query: 170 PSITYAIIGSSVIFVL 185
PS+ S+V F++
Sbjct: 2434 PSLPALWAASTVPFMM 2449
Score = 39.3 bits (90), Expect = 0.005
Identities = 22/68 (32%), Positives = 34/68 (50%), Gaps = 10/68 (14%)
Query: 112 LCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQVFVTSE-------- 163
LC C +G C+ + CDG +C+D SDEE C E G+G+ T++
Sbjct: 2233 LCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGCVLLPE-GTGRFHSTAKTLALSSAQ 2291
Query: 164 -NQLVYYP 170
QL+++P
Sbjct: 2292 PGQLLHWP 2299
Score = 38.1 bits (87), Expect = 0.012
Identities = 22/68 (32%), Positives = 28/68 (41%), Gaps = 4/68 (5%)
Query: 1 MWLLGPLCLLLSSAAESQL----LPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCF 56
MWL L +S + LPG + P C +G C+ +CD PDC
Sbjct: 2431 MWLPSLPALWAASTVPFMMPTMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQ 2490
Query: 57 DKSDEKEC 64
D SDE C
Sbjct: 2491 DGSDEDGC 2498
Score = 35.0 bits (79), Expect = 0.098
Identities = 13/28 (46%), Positives = 18/28 (64%)
Query: 37 CSNGRCIPGAWQCDGLPDCFDKSDEKEC 64
C++G C+ CDG+ DC D SDE+ C
Sbjct: 2241 CASGECVLRGGPCDGVLDCEDGSDEEGC 2268
Score = 32.3 bits (72), Expect = 0.64
Identities = 23/107 (21%), Positives = 37/107 (34%), Gaps = 12/107 (11%)
Query: 37 CSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFF----PCASGIHCIIGRF--- 89
C+ G C +C+ F +CP + + PC G C G+
Sbjct: 4659 CNGGPCP----ECEAQDTVFTLDCANQCPHSCADLWDRVQCLQGPCRPGCRCPPGQLVQD 4714
Query: 90 -RCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQ 135
RC C G N + + C+N C+++S +C Q
Sbjct: 4715 GRCVPISSCRCGLPSANASWELAPAQAVQLDCQNCTCVNESLVCPHQ 4761
Score = 28.5 bits (62), Expect = 9.2
Identities = 10/21 (47%), Positives = 12/21 (57%)
Query: 37 CSNGRCIPGAWQCDGLPDCFD 57
C N C+ G QC +PDC D
Sbjct: 3624 CDNCTCVAGILQCQEVPDCPD 3644
>gi|167555125 low density lipoprotein receptor-related protein 3
[Homo sapiens]
Length = 770
Score = 90.9 bits (224), Expect = 2e-18
Identities = 54/150 (36%), Positives = 71/150 (47%), Gaps = 25/150 (16%)
Query: 42 CIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIH-CIIGRFRCNGFEDCPDG 100
C +CDG C DE+ CP C P +PC G C RCN + CPDG
Sbjct: 391 CFSEPQRCDGWWHCASGRDEQGCPA----CPPDQYPCEGGSGLCYTPADRCNNQKSCPDG 446
Query: 101 SDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQVFV 160
+DE+NC + C +HC LCI +++ CDGQ +CQD SDE C ++
Sbjct: 447 ADEKNCFS----CQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLAA---------- 492
Query: 161 TSENQLVYYPSITYAIIGSSVIFVLVVALL 190
V IT A+IGS V +L+V L
Sbjct: 493 ------VPRKVITAALIGSLVCGLLLVIAL 516
Score = 73.6 bits (179), Expect = 2e-13
Identities = 34/79 (43%), Positives = 43/79 (54%), Gaps = 7/79 (8%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSK-----CGPTFFPC--ASGIHCIIG 87
F C NG+C+PG WQC+ + +C D SDE C S+ C FPC A C+
Sbjct: 171 FRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARSTRCLPV 230
Query: 88 RFRCNGFEDCPDGSDEENC 106
RC+G +DC DGSDE C
Sbjct: 231 ERRCDGLQDCGDGSDEAGC 249
Score = 58.5 bits (140), Expect = 8e-09
Identities = 31/79 (39%), Positives = 39/79 (49%), Gaps = 7/79 (8%)
Query: 32 PGNFMCSNGR--CIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRF 89
P + C G C A +C+ C D +DEK C C P F C + + CI +
Sbjct: 418 PDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNC----FSCQPGTFHCGTNL-CIFETW 472
Query: 90 RCNGFEDCPDGSDEENCTA 108
RC+G EDC DGSDE C A
Sbjct: 473 RCDGQEDCQDGSDEHGCLA 491
Score = 55.5 bits (132), Expect = 7e-08
Identities = 30/88 (34%), Positives = 44/88 (50%), Gaps = 9/88 (10%)
Query: 68 KSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANP-----LLCSTARYHC-- 120
++ C F C +G C+ G ++CN ++C DGSDE NC+A LC + C
Sbjct: 163 QASCQADEFRCDNG-KCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSG 221
Query: 121 -KNGLCIDKSFICDGQNNCQDNSDEESC 147
++ C+ CDG +C D SDE C
Sbjct: 222 ARSTRCLPVERRCDGLQDCGDGSDEAGC 249
Score = 41.2 bits (95), Expect = 0.001
Identities = 26/68 (38%), Positives = 29/68 (42%), Gaps = 16/68 (23%)
Query: 33 GNFMCSNGR---CIPGAWQCDGLPDCFDKSDEKECPKAK----------SKCGPTFFPCA 79
G F CS R C+P +CDGL DC D SDE CP S P F A
Sbjct: 215 GTFPCSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAA 274
Query: 80 SG---IHC 84
G +HC
Sbjct: 275 RGPSDLHC 282
Score = 37.7 bits (86), Expect = 0.015
Identities = 16/45 (35%), Positives = 24/45 (53%), Gaps = 2/45 (4%)
Query: 113 CSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCE--SSQEPGS 155
C + C NG C+ + C+ + C D SDE +C +S+ PGS
Sbjct: 166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGS 210
>gi|208973262 low density lipoprotein-related protein 12 isoform b
precursor [Homo sapiens]
Length = 840
Score = 89.7 bits (221), Expect = 3e-18
Identities = 54/161 (33%), Positives = 74/161 (45%), Gaps = 25/161 (15%)
Query: 31 IPGNFMCS-NGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRF 89
+P C N C +CDG C + DE C + C FPC+ C
Sbjct: 357 LPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNC----TMCQKEEFPCSRNGVCYPRSD 412
Query: 90 RCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCES 149
RCN CP+GSDE+NC C +HCKN C+ +S++CD Q++C D SDEE+C
Sbjct: 413 RCNYQNHCPNGSDEKNC----FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCP- 467
Query: 150 SQEPGSGQVFVTSENQLVYYPSITYAIIGSSVIFVLVVALL 190
+V IT A+IGS + +L+V L
Sbjct: 468 ---------------VIVPTRVITAAVIGSLICGLLLVIAL 493
Score = 62.0 bits (149), Expect = 8e-10
Identities = 32/84 (38%), Positives = 42/84 (50%), Gaps = 12/84 (14%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPK-AKSKCGPTFFPCASGIHCIIGRF---- 89
F C NG+CIP AW+C+ + +C D SDE+ C K A F PCA + RF
Sbjct: 152 FRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVY 211
Query: 90 -------RCNGFEDCPDGSDEENC 106
+C+G DC D DE +C
Sbjct: 212 TCLPESLKCDGNIDCLDLGDEIDC 235
Score = 51.6 bits (122), Expect = 1e-06
Identities = 33/104 (31%), Positives = 47/104 (45%), Gaps = 21/104 (20%)
Query: 58 KSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCT--ANPLL--- 112
KS+E C + +CG CI ++CN ++C D SDEE C ANP
Sbjct: 141 KSEEPNCACDQFRCGNG--------KCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAA 192
Query: 113 ---CSTARYHC-----KNGLCIDKSFICDGQNNCQDNSDEESCE 148
C+ ++ C K C+ +S CDG +C D DE C+
Sbjct: 193 FQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCD 236
Score = 43.9 bits (102), Expect = 2e-04
Identities = 19/59 (32%), Positives = 30/59 (50%), Gaps = 7/59 (11%)
Query: 101 SDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQVF 159
S+E NC + ++ C NG CI +++ C+ + C D+SDEE C P + F
Sbjct: 142 SEEPNCACD-------QFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAF 193
>gi|7305525 low density lipoprotein-related protein 12 isoform a
precursor [Homo sapiens]
Length = 859
Score = 89.7 bits (221), Expect = 3e-18
Identities = 54/161 (33%), Positives = 74/161 (45%), Gaps = 25/161 (15%)
Query: 31 IPGNFMCS-NGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRF 89
+P C N C +CDG C + DE C + C FPC+ C
Sbjct: 376 LPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNC----TMCQKEEFPCSRNGVCYPRSD 431
Query: 90 RCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCES 149
RCN CP+GSDE+NC C +HCKN C+ +S++CD Q++C D SDEE+C
Sbjct: 432 RCNYQNHCPNGSDEKNC----FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCP- 486
Query: 150 SQEPGSGQVFVTSENQLVYYPSITYAIIGSSVIFVLVVALL 190
+V IT A+IGS + +L+V L
Sbjct: 487 ---------------VIVPTRVITAAVIGSLICGLLLVIAL 512
Score = 62.0 bits (149), Expect = 8e-10
Identities = 32/84 (38%), Positives = 42/84 (50%), Gaps = 12/84 (14%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPK-AKSKCGPTFFPCASGIHCIIGRF---- 89
F C NG+CIP AW+C+ + +C D SDE+ C K A F PCA + RF
Sbjct: 171 FRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVY 230
Query: 90 -------RCNGFEDCPDGSDEENC 106
+C+G DC D DE +C
Sbjct: 231 TCLPESLKCDGNIDCLDLGDEIDC 254
Score = 51.6 bits (122), Expect = 1e-06
Identities = 33/104 (31%), Positives = 47/104 (45%), Gaps = 21/104 (20%)
Query: 58 KSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCT--ANPLL--- 112
KS+E C + +CG CI ++CN ++C D SDEE C ANP
Sbjct: 160 KSEEPNCACDQFRCGNG--------KCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAA 211
Query: 113 ---CSTARYHC-----KNGLCIDKSFICDGQNNCQDNSDEESCE 148
C+ ++ C K C+ +S CDG +C D DE C+
Sbjct: 212 FQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCD 255
Score = 43.9 bits (102), Expect = 2e-04
Identities = 19/59 (32%), Positives = 30/59 (50%), Gaps = 7/59 (11%)
Query: 101 SDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQVF 159
S+E NC + ++ C NG CI +++ C+ + C D+SDEE C P + F
Sbjct: 161 SEEPNCACD-------QFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAF 212
>gi|32490559 low density lipoprotein receptor-related protein 10
precursor [Homo sapiens]
Length = 713
Score = 86.7 bits (213), Expect = 3e-17
Identities = 55/183 (30%), Positives = 85/183 (46%), Gaps = 31/183 (16%)
Query: 41 RCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASG-----IHCIIGRFRCNGFE 95
RC A +CDG DC D +DE++CP C P FPC + C + RCN
Sbjct: 330 RCYSEAQRCDGSWDCADGTDEEDCPG----CPPGHFPCGAAGTSGATACYLPADRCNYQT 385
Query: 96 DCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGS 155
C DG+DE C C + C++ C+ ++++CDGQ +C D SDE C
Sbjct: 386 FCADGADERRCRH----CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC-------- 433
Query: 156 GQVFVTSENQLVYYPSITYAIIGSSVIFVLVVALLALV--LHHQRKRNNLMTLPVHRLQH 213
+ ++ IT A+IGS V +L+V L L+ R + + P+ R++
Sbjct: 434 --------SYVLPRKVITAAVIGSLVCGLLLVIALGCTCKLYAIRTQEYSIFAPLSRMEA 485
Query: 214 PVL 216
++
Sbjct: 486 EIV 488
Score = 48.9 bits (115), Expect = 7e-06
Identities = 18/33 (54%), Positives = 22/33 (66%)
Query: 32 PGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKEC 64
PGNF C + +C+ W CDG PDC D SDE +C
Sbjct: 401 PGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
Score = 40.4 bits (93), Expect = 0.002
Identities = 17/44 (38%), Positives = 21/44 (47%)
Query: 111 LLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQEPG 154
L+C + C N C+ CDG + C D SDE C S PG
Sbjct: 138 LMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFPG 181
Score = 38.9 bits (89), Expect = 0.007
Identities = 23/77 (29%), Positives = 32/77 (41%), Gaps = 6/77 (7%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKEC-----PKAKSKCGPTFFPCASGIHCIIGRF 89
F C N RC+ +CDG+ C D SDE C P + P+ PC + G F
Sbjct: 145 FQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFPGLTPRPVPS-LPCNVTLEDFYGVF 203
Query: 90 RCNGFEDCPDGSDEENC 106
G+ S ++C
Sbjct: 204 SSPGYTHLASVSHPQSC 220
Score = 34.3 bits (77), Expect = 0.17
Identities = 14/34 (41%), Positives = 20/34 (58%)
Query: 84 CIIGRFRCNGFEDCPDGSDEENCTANPLLCSTAR 117
C+ RC+G + C DGSDE C+++P T R
Sbjct: 152 CVSAVQRCDGVDACGDGSDEAGCSSDPFPGLTPR 185
>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
Length = 811
Score = 86.3 bits (212), Expect = 4e-17
Identities = 53/146 (36%), Positives = 77/146 (52%), Gaps = 15/146 (10%)
Query: 32 PGNFMCS-NGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFR 90
PG F+CS NG C+P CDG+ DC + DE+ C C TF C CI
Sbjct: 459 PGEFLCSVNGLCVPA---CDGVKDCPNGLDERNCV-----CRATF-QCKEDSTCISLPKV 509
Query: 91 CNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDK-SFICDGQNNCQDNSDEESCES 149
C+G DC +GSDEE C + C T + C++ C+ K + CDG+ +C+D SDEE C+
Sbjct: 510 CDGQPDCLNGSDEEQCQEG-VPCGTFTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHCDC 568
Query: 150 SQEPGSGQVF---VTSENQLVYYPSI 172
+ S ++ V+SE + + S+
Sbjct: 569 GLQGPSSRIVGGAVSSEGEWPWQASL 594
Score = 57.8 bits (138), Expect = 1e-08
Identities = 29/83 (34%), Positives = 40/83 (48%), Gaps = 10/83 (12%)
Query: 77 PCASGIHCIIGRF---RCNGFEDCPDGSDEENCTANPLLCSTARYHCK-NGLCIDKSFIC 132
PC C + C+G +DCP+G DE NC A + CK + CI +C
Sbjct: 457 PCPGEFLCSVNGLCVPACDGVKDCPNGLDERNCVCR------ATFQCKEDSTCISLPKVC 510
Query: 133 DGQNNCQDNSDEESCESSQEPGS 155
DGQ +C + SDEE C+ G+
Sbjct: 511 DGQPDCLNGSDEEQCQEGVPCGT 533
>gi|7706111 8D6 antigen [Homo sapiens]
Length = 282
Score = 72.8 bits (177), Expect = 4e-13
Identities = 42/126 (33%), Positives = 61/126 (48%), Gaps = 16/126 (12%)
Query: 32 PGNFMC-SNGRCIPGAWQCDGLPDCFDKSDEKECP----KAKSKCGPTFFPCASGIHCII 86
P F C ++G C+P W+CD DC D SDE+EC K +C P G+ C
Sbjct: 56 PTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPP-----PPGLPC-- 108
Query: 87 GRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCK-NGLCIDKSFICDGQNNCQDNSDEE 145
C G DC G+D++ + L C C + CI ++ CDG +C D+SDE
Sbjct: 109 ---PCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDEL 165
Query: 146 SCESSQ 151
C +++
Sbjct: 166 GCGTNE 171
Score = 40.0 bits (92), Expect = 0.003
Identities = 17/35 (48%), Positives = 21/35 (60%), Gaps = 1/35 (2%)
Query: 31 IPGNFMCS-NGRCIPGAWQCDGLPDCFDKSDEKEC 64
+ G C+ + CIP W+CDG PDC D SDE C
Sbjct: 133 LAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGC 167
Score = 37.7 bits (86), Expect = 0.015
Identities = 16/46 (34%), Positives = 24/46 (52%), Gaps = 1/46 (2%)
Query: 113 CSTARYHCK-NGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQ 157
C ++ C+ +GLC+ ++ CD +C D SDEE C GQ
Sbjct: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQ 99
>gi|239755250 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1542
Score = 72.4 bits (176), Expect = 6e-13
Identities = 45/130 (34%), Positives = 58/130 (44%), Gaps = 13/130 (10%)
Query: 50 DGLPDCF----DKSDEKEC------PKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPD 99
DG D F D S EC P S C F C + C+ +C+G EDC D
Sbjct: 1307 DGNEDIFIALDDISFTPECVTGGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCID 1366
Query: 100 GSDEENCTANPL--LCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQ 157
GSDE +C NP LCS + C CI +CDG +C N DE C S++ +G
Sbjct: 1367 GSDEMDCPLNPTPPLCSNMEFPCSTDECIPSLLLCDGVPDCHFNEDELIC-SNKSCSNGA 1425
Query: 158 VFVTSENQLV 167
+ S N +
Sbjct: 1426 LVCASSNSCI 1435
Score = 66.2 bits (160), Expect = 4e-11
Identities = 40/114 (35%), Positives = 52/114 (45%), Gaps = 7/114 (6%)
Query: 41 RCIPGAWQCDGLPDCFDKSDEKECP--KAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCP 98
+C+P + +CDG DC D SDE +CP C FPC++ CI C+G DC
Sbjct: 1350 QCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTD-ECIPSLLLCDGVPDCH 1408
Query: 99 DGSDEENCTANPLLCSTARYHC-KNGLCIDKSFICDGQNNCQD-NSDEESCESS 150
DE C+ CS C + CI CDG +C D DE SC +
Sbjct: 1409 FNEDELICSNKS--CSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESSCSDT 1460
Score = 61.2 bits (147), Expect = 1e-09
Identities = 31/74 (41%), Positives = 36/74 (48%), Gaps = 3/74 (4%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGF 94
F CS CIP CDG+PDC DE C + C CAS CI RC+GF
Sbjct: 1387 FPCSTDECIPSLLLCDGVPDCHFNEDELIC--SNKSCSNGALVCASSNSCIPAHQRCDGF 1444
Query: 95 EDCPDGS-DEENCT 107
DC D DE +C+
Sbjct: 1445 ADCMDFQLDESSCS 1458
Score = 41.2 bits (95), Expect = 0.001
Identities = 22/65 (33%), Positives = 29/65 (44%)
Query: 17 SQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFF 76
S LL + C +F+C + +CI CD PDC +SDE C S G F
Sbjct: 1107 SALLSVGEISELCPEITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHCAHYTSTTGSCNF 1166
Query: 77 PCASG 81
+SG
Sbjct: 1167 ETSSG 1171
Score = 40.4 bits (93), Expect = 0.002
Identities = 24/60 (40%), Positives = 32/60 (53%), Gaps = 10/60 (16%)
Query: 94 FEDC-PDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEES--CESS 150
F+DC P S E CT + +C+ N CI K +CD N+C DNSDE + C +S
Sbjct: 616 FQDCSPLLSPERKCTDHEFMCA-------NKHCIAKDKLCDFVNDCADNSDETTFICRTS 668
Score = 38.1 bits (87), Expect = 0.012
Identities = 18/43 (41%), Positives = 24/43 (55%), Gaps = 6/43 (13%)
Query: 105 NCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESC 147
NCT N +C + +G CI+K CD + +C D SDE SC
Sbjct: 414 NCTDNEFICRS------DGHCIEKMQKCDFKYDCPDKSDEASC 450
Score = 35.4 bits (80), Expect = 0.075
Identities = 18/47 (38%), Positives = 23/47 (48%), Gaps = 2/47 (4%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKE--CPKAKSKCGPTFFPCA 79
FMC+N CI CD + DC D SDE C + +C F C+
Sbjct: 634 FMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEFDLCS 680
Score = 35.0 bits (79), Expect = 0.098
Identities = 20/46 (43%), Positives = 25/46 (54%), Gaps = 6/46 (13%)
Query: 20 LPGNNFTNECNIPGNFMC-SNGRCIPGAWQCDGLPDCFDKSDEKEC 64
LP +N T+ F+C S+G CI +CD DC DKSDE C
Sbjct: 410 LPPHNCTDN-----EFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 450
Score = 35.0 bits (79), Expect = 0.098
Identities = 16/36 (44%), Positives = 19/36 (52%)
Query: 71 CGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENC 106
C F C S HCI +C+ DCPD SDE +C
Sbjct: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 450
Score = 32.3 bits (72), Expect = 0.64
Identities = 18/53 (33%), Positives = 21/53 (39%), Gaps = 1/53 (1%)
Query: 99 DGSDEENCTANPL-LCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESS 150
D EE P C C NG C C+ +NC DN+ E C SS
Sbjct: 833 DSVQEELAVPLPTGFCPLGYRECHNGKCYRLEQSCNFVDNCGDNTGENKCGSS 885
Score = 30.4 bits (67), Expect = 2.4
Identities = 24/87 (27%), Positives = 38/87 (43%), Gaps = 12/87 (13%)
Query: 70 KCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKS 129
KC F CA+ HCI C+ DC D SDE +C T+ +G C +
Sbjct: 628 KCTDHEFMCANK-HCIAKDKLCDFVNDCADNSDE-----TTFICRTS-----SGRCDFEF 676
Query: 130 FICDGQNNCQDNSDEESCESSQEPGSG 156
+C + +D + + ++S P +G
Sbjct: 677 DLCSWKQE-KDEDFDWNLKASSIPAAG 702
Score = 30.0 bits (66), Expect = 3.2
Identities = 28/116 (24%), Positives = 40/116 (34%), Gaps = 22/116 (18%)
Query: 61 EKECPKAKS---KCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTAR 117
E ECP+ +S K P P +G E CP+ +D
Sbjct: 1084 EPECPRGRSALLKGPPQEEPNRRSALLSVGEIS----ELCPEITD--------------- 1124
Query: 118 YHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQVFVTSENQLVYYPSIT 173
+ C++ CI +CD + +C SDE C F TS S+T
Sbjct: 1125 FLCRDKKCIASHLLCDYKPDCSGRSDEAHCAHYTSTTGSCNFETSSGNWTTACSLT 1180
Score = 29.6 bits (65), Expect = 4.1
Identities = 17/49 (34%), Positives = 27/49 (55%), Gaps = 6/49 (12%)
Query: 104 ENCTANPLLCSTAR----YHCKNG-LCIDKSFICDGQNNCQDNSDEESC 147
ENCT PL + + C++ CI+K +CD ++C D +DE +C
Sbjct: 177 ENCTL-PLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNC 224
Score = 28.5 bits (62), Expect = 9.2
Identities = 21/75 (28%), Positives = 28/75 (37%), Gaps = 15/75 (20%)
Query: 29 CNIPGNFMCSNGR-CIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIG 87
C +F C + R CI CD + DC D++DE CA + C
Sbjct: 188 CEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVN--------------CAPELQCNFE 233
Query: 88 RFRCNGFEDCPDGSD 102
CN +D D D
Sbjct: 234 TGICNWEQDAKDDFD 248
>gi|239749752 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1817
Score = 72.4 bits (176), Expect = 6e-13
Identities = 45/130 (34%), Positives = 58/130 (44%), Gaps = 13/130 (10%)
Query: 50 DGLPDCF----DKSDEKEC------PKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPD 99
DG D F D S EC P S C F C + C+ +C+G EDC D
Sbjct: 1582 DGNEDIFIALDDISFTPECVTGGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCID 1641
Query: 100 GSDEENCTANPL--LCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQ 157
GSDE +C NP LCS + C CI +CDG +C N DE C S++ +G
Sbjct: 1642 GSDEMDCPLNPTPPLCSNMEFPCSTDECIPSLLLCDGVPDCHFNEDELIC-SNKSCSNGA 1700
Query: 158 VFVTSENQLV 167
+ S N +
Sbjct: 1701 LVCASSNSCI 1710
Score = 66.2 bits (160), Expect = 4e-11
Identities = 40/114 (35%), Positives = 52/114 (45%), Gaps = 7/114 (6%)
Query: 41 RCIPGAWQCDGLPDCFDKSDEKECP--KAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCP 98
+C+P + +CDG DC D SDE +CP C FPC++ CI C+G DC
Sbjct: 1625 QCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTD-ECIPSLLLCDGVPDCH 1683
Query: 99 DGSDEENCTANPLLCSTARYHC-KNGLCIDKSFICDGQNNCQD-NSDEESCESS 150
DE C+ CS C + CI CDG +C D DE SC +
Sbjct: 1684 FNEDELICSNKS--CSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESSCSDT 1735
Score = 61.2 bits (147), Expect = 1e-09
Identities = 31/74 (41%), Positives = 36/74 (48%), Gaps = 3/74 (4%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGF 94
F CS CIP CDG+PDC DE C + C CAS CI RC+GF
Sbjct: 1662 FPCSTDECIPSLLLCDGVPDCHFNEDELIC--SNKSCSNGALVCASSNSCIPAHQRCDGF 1719
Query: 95 EDCPDGS-DEENCT 107
DC D DE +C+
Sbjct: 1720 ADCMDFQLDESSCS 1733
Score = 43.9 bits (102), Expect = 2e-04
Identities = 23/65 (35%), Positives = 30/65 (46%)
Query: 17 SQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFF 76
S LL + C +F+C + +CI CD PDC D+SDE C S G F
Sbjct: 1382 SALLSVGEISELCPEITDFLCRDKKCIASHLLCDYKPDCSDRSDEAHCAHYTSTTGSCNF 1441
Query: 77 PCASG 81
+SG
Sbjct: 1442 ETSSG 1446
Score = 42.4 bits (98), Expect = 6e-04
Identities = 17/45 (37%), Positives = 25/45 (55%)
Query: 107 TANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQ 151
T + LCS + C +G CI K +CD + +C D SDE+ S+
Sbjct: 68 TQSRKLCSADEFPCTSGQCIAKESVCDSRQDCSDESDEDPATCSK 112
Score = 40.4 bits (93), Expect = 0.002
Identities = 24/60 (40%), Positives = 32/60 (53%), Gaps = 10/60 (16%)
Query: 94 FEDC-PDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEES--CESS 150
F+DC P S E CT + +C+ N CI K +CD N+C DNSDE + C +S
Sbjct: 891 FQDCSPLLSPERKCTDHEFMCA-------NKHCIAKDKLCDFVNDCADNSDETTFICRTS 943
Score = 38.1 bits (87), Expect = 0.012
Identities = 18/43 (41%), Positives = 24/43 (55%), Gaps = 6/43 (13%)
Query: 105 NCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESC 147
NCT N +C + +G CI+K CD + +C D SDE SC
Sbjct: 689 NCTDNEFICRS------DGHCIEKMQKCDFKYDCPDKSDEASC 725
Score = 35.4 bits (80), Expect = 0.075
Identities = 18/47 (38%), Positives = 23/47 (48%), Gaps = 2/47 (4%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKE--CPKAKSKCGPTFFPCA 79
FMC+N CI CD + DC D SDE C + +C F C+
Sbjct: 909 FMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEFDLCS 955
Score = 35.0 bits (79), Expect = 0.098
Identities = 16/44 (36%), Positives = 23/44 (52%), Gaps = 1/44 (2%)
Query: 66 KAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTAN 109
+++ C FPC SG CI C+ +DC D SDE+ T +
Sbjct: 69 QSRKLCSADEFPCTSG-QCIAKESVCDSRQDCSDESDEDPATCS 111
Score = 35.0 bits (79), Expect = 0.098
Identities = 20/46 (43%), Positives = 25/46 (54%), Gaps = 6/46 (13%)
Query: 20 LPGNNFTNECNIPGNFMC-SNGRCIPGAWQCDGLPDCFDKSDEKEC 64
LP +N T+ F+C S+G CI +CD DC DKSDE C
Sbjct: 685 LPPHNCTDN-----EFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 725
Score = 35.0 bits (79), Expect = 0.098
Identities = 16/36 (44%), Positives = 19/36 (52%)
Query: 71 CGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENC 106
C F C S HCI +C+ DCPD SDE +C
Sbjct: 690 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 725
Score = 32.7 bits (73), Expect = 0.49
Identities = 13/27 (48%), Positives = 17/27 (62%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDE 61
F C++G+CI CD DC D+SDE
Sbjct: 79 FPCTSGQCIAKESVCDSRQDCSDESDE 105
Score = 32.7 bits (73), Expect = 0.49
Identities = 29/116 (25%), Positives = 41/116 (35%), Gaps = 22/116 (18%)
Query: 61 EKECPKAKS---KCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTAR 117
E ECP+ +S K P P +G E CP+ +D
Sbjct: 1359 EPECPRGRSALLKGPPQEKPNRRSALLSVGEIS----ELCPEITD--------------- 1399
Query: 118 YHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQVFVTSENQLVYYPSIT 173
+ C++ CI +CD + +C D SDE C F TS S+T
Sbjct: 1400 FLCRDKKCIASHLLCDYKPDCSDRSDEAHCAHYTSTTGSCNFETSSGNWTTACSLT 1455
Score = 32.3 bits (72), Expect = 0.64
Identities = 18/53 (33%), Positives = 21/53 (39%), Gaps = 1/53 (1%)
Query: 99 DGSDEENCTANPL-LCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESS 150
D EE P C C NG C C+ +NC DN+ E C SS
Sbjct: 1108 DSVQEELAVPLPTGFCPLGYRECHNGKCYRLEQSCNFVDNCGDNTGENKCGSS 1160
Score = 30.4 bits (67), Expect = 2.4
Identities = 24/87 (27%), Positives = 38/87 (43%), Gaps = 12/87 (13%)
Query: 70 KCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKS 129
KC F CA+ HCI C+ DC D SDE +C T+ +G C +
Sbjct: 903 KCTDHEFMCANK-HCIAKDKLCDFVNDCADNSDE-----TTFICRTS-----SGRCDFEF 951
Query: 130 FICDGQNNCQDNSDEESCESSQEPGSG 156
+C + +D + + ++S P +G
Sbjct: 952 DLCSWKQE-KDEDFDWNLKASSIPAAG 977
Score = 29.6 bits (65), Expect = 4.1
Identities = 17/49 (34%), Positives = 27/49 (55%), Gaps = 6/49 (12%)
Query: 104 ENCTANPLLCSTAR----YHCKNG-LCIDKSFICDGQNNCQDNSDEESC 147
ENCT PL + + C++ CI+K +CD ++C D +DE +C
Sbjct: 452 ENCTL-PLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNC 499
Score = 28.5 bits (62), Expect = 9.2
Identities = 21/75 (28%), Positives = 28/75 (37%), Gaps = 15/75 (20%)
Query: 29 CNIPGNFMCSNGR-CIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIG 87
C +F C + R CI CD + DC D++DE CA + C
Sbjct: 463 CEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVN--------------CAPELQCNFE 508
Query: 88 RFRCNGFEDCPDGSD 102
CN +D D D
Sbjct: 509 TGICNWEQDAKDDFD 523
>gi|239744011 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1817
Score = 70.5 bits (171), Expect = 2e-12
Identities = 44/130 (33%), Positives = 58/130 (44%), Gaps = 13/130 (10%)
Query: 50 DGLPDCF----DKSDEKEC------PKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPD 99
DG D F D S EC P S C F C + C+ +C+G EDC D
Sbjct: 1582 DGNEDIFIALDDISFTPECVTGGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCID 1641
Query: 100 GSDEENCTANPL--LCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQ 157
GSDE +C +P LCS + C CI +CDG +C N DE C S++ +G
Sbjct: 1642 GSDEMDCPLSPTPPLCSNMEFPCSTDECIPSLLLCDGVPDCHFNEDELIC-SNKSCSNGA 1700
Query: 158 VFVTSENQLV 167
+ S N +
Sbjct: 1701 LVCASSNSCI 1710
Score = 67.4 bits (163), Expect = 2e-11
Identities = 40/114 (35%), Positives = 54/114 (47%), Gaps = 7/114 (6%)
Query: 41 RCIPGAWQCDGLPDCFDKSDEKECPKAKSK--CGPTFFPCASGIHCIIGRFRCNGFEDCP 98
+C+P + +CDG DC D SDE +CP + + C FPC++ CI C+G DC
Sbjct: 1625 QCVPLSGKCDGHEDCIDGSDEMDCPLSPTPPLCSNMEFPCSTD-ECIPSLLLCDGVPDCH 1683
Query: 99 DGSDEENCTANPLLCSTARYHC-KNGLCIDKSFICDGQNNCQD-NSDEESCESS 150
DE C+ CS C + CI CDG +C D DE SC +
Sbjct: 1684 FNEDELICSNKS--CSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESSCSDT 1735
Score = 61.2 bits (147), Expect = 1e-09
Identities = 31/74 (41%), Positives = 36/74 (48%), Gaps = 3/74 (4%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGF 94
F CS CIP CDG+PDC DE C + C CAS CI RC+GF
Sbjct: 1662 FPCSTDECIPSLLLCDGVPDCHFNEDELIC--SNKSCSNGALVCASSNSCIPAHQRCDGF 1719
Query: 95 EDCPDGS-DEENCT 107
DC D DE +C+
Sbjct: 1720 ADCMDFQLDESSCS 1733
Score = 43.9 bits (102), Expect = 2e-04
Identities = 23/65 (35%), Positives = 30/65 (46%)
Query: 17 SQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFF 76
S LL + C +F+C + +CI CD PDC D+SDE C S G F
Sbjct: 1382 SALLSVGEISELCPEITDFLCRDKKCIASHLLCDYKPDCSDRSDEAHCAHYTSTTGSCNF 1441
Query: 77 PCASG 81
+SG
Sbjct: 1442 ETSSG 1446
Score = 42.4 bits (98), Expect = 6e-04
Identities = 17/45 (37%), Positives = 25/45 (55%)
Query: 107 TANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQ 151
T + LCS + C +G CI K +CD + +C D SDE+ S+
Sbjct: 68 TQSRKLCSADEFPCTSGQCIAKESVCDSRQDCSDESDEDPATCSK 112
Score = 40.4 bits (93), Expect = 0.002
Identities = 24/60 (40%), Positives = 32/60 (53%), Gaps = 10/60 (16%)
Query: 94 FEDC-PDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEES--CESS 150
F+DC P S E CT + +C+ N CI K +CD N+C DNSDE + C +S
Sbjct: 891 FQDCSPLLSPERKCTDHEFMCA-------NKHCIAKDKLCDFVNDCADNSDETTFICRTS 943
Score = 38.1 bits (87), Expect = 0.012
Identities = 18/43 (41%), Positives = 24/43 (55%), Gaps = 6/43 (13%)
Query: 105 NCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESC 147
NCT N +C + +G CI+K CD + +C D SDE SC
Sbjct: 689 NCTDNEFICRS------DGHCIEKMQKCDFKYDCPDKSDEASC 725
Score = 35.4 bits (80), Expect = 0.075
Identities = 18/47 (38%), Positives = 23/47 (48%), Gaps = 2/47 (4%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKE--CPKAKSKCGPTFFPCA 79
FMC+N CI CD + DC D SDE C + +C F C+
Sbjct: 909 FMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEFDLCS 955
Score = 35.0 bits (79), Expect = 0.098
Identities = 16/44 (36%), Positives = 23/44 (52%), Gaps = 1/44 (2%)
Query: 66 KAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTAN 109
+++ C FPC SG CI C+ +DC D SDE+ T +
Sbjct: 69 QSRKLCSADEFPCTSG-QCIAKESVCDSRQDCSDESDEDPATCS 111
Score = 35.0 bits (79), Expect = 0.098
Identities = 20/46 (43%), Positives = 25/46 (54%), Gaps = 6/46 (13%)
Query: 20 LPGNNFTNECNIPGNFMC-SNGRCIPGAWQCDGLPDCFDKSDEKEC 64
LP +N T+ F+C S+G CI +CD DC DKSDE C
Sbjct: 685 LPPHNCTDN-----EFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 725
Score = 35.0 bits (79), Expect = 0.098
Identities = 16/36 (44%), Positives = 19/36 (52%)
Query: 71 CGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENC 106
C F C S HCI +C+ DCPD SDE +C
Sbjct: 690 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 725
Score = 35.0 bits (79), Expect = 0.098
Identities = 19/53 (35%), Positives = 22/53 (41%), Gaps = 1/53 (1%)
Query: 99 DGSDEENCTANPL-LCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESS 150
D EE P C C NG C C+ +NC DN+DE C SS
Sbjct: 1108 DSVQEELAVPLPTGFCPLGYRECHNGKCYRLEQSCNFVDNCGDNTDENECGSS 1160
Score = 32.7 bits (73), Expect = 0.49
Identities = 13/27 (48%), Positives = 17/27 (62%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDE 61
F C++G+CI CD DC D+SDE
Sbjct: 79 FPCTSGQCIAKESVCDSRQDCSDESDE 105
Score = 32.7 bits (73), Expect = 0.49
Identities = 29/116 (25%), Positives = 41/116 (35%), Gaps = 22/116 (18%)
Query: 61 EKECPKAKS---KCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTAR 117
E ECP+ +S K P P +G E CP+ +D
Sbjct: 1359 EPECPRGRSALLKGPPQEKPNRRSALLSVGEIS----ELCPEITD--------------- 1399
Query: 118 YHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQVFVTSENQLVYYPSIT 173
+ C++ CI +CD + +C D SDE C F TS S+T
Sbjct: 1400 FLCRDKKCIASHLLCDYKPDCSDRSDEAHCAHYTSTTGSCNFETSSGNWTTACSLT 1455
Score = 32.0 bits (71), Expect = 0.83
Identities = 23/72 (31%), Positives = 33/72 (45%), Gaps = 12/72 (16%)
Query: 8 CLLLSSAAESQL---LPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKEC 64
CL L + + +L LP T C + G C NG+C C+ + +C D +DE EC
Sbjct: 1103 CLSLHDSVQEELAVPLP----TGFCPL-GYRECHNGKCYRLEQSCNFVDNCGDNTDENEC 1157
Query: 65 PKA----KSKCG 72
+ K CG
Sbjct: 1158 GSSCTFEKGWCG 1169
Score = 30.4 bits (67), Expect = 2.4
Identities = 24/87 (27%), Positives = 38/87 (43%), Gaps = 12/87 (13%)
Query: 70 KCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKS 129
KC F CA+ HCI C+ DC D SDE +C T+ +G C +
Sbjct: 903 KCTDHEFMCANK-HCIAKDKLCDFVNDCADNSDE-----TTFICRTS-----SGRCDFEF 951
Query: 130 FICDGQNNCQDNSDEESCESSQEPGSG 156
+C + +D + + ++S P +G
Sbjct: 952 DLCSWKQE-KDEDFDWNLKASSIPAAG 977
Score = 29.6 bits (65), Expect = 4.1
Identities = 17/49 (34%), Positives = 27/49 (55%), Gaps = 6/49 (12%)
Query: 104 ENCTANPLLCSTAR----YHCKNG-LCIDKSFICDGQNNCQDNSDEESC 147
ENCT PL + + C++ CI+K +CD ++C D +DE +C
Sbjct: 452 ENCTL-PLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNC 499
Score = 28.5 bits (62), Expect = 9.2
Identities = 21/75 (28%), Positives = 28/75 (37%), Gaps = 15/75 (20%)
Query: 29 CNIPGNFMCSNGR-CIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIG 87
C +F C + R CI CD + DC D++DE CA + C
Sbjct: 463 CEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVN--------------CAPELQCNFE 508
Query: 88 RFRCNGFEDCPDGSD 102
CN +D D D
Sbjct: 509 TGICNWEQDAKDDFD 523
>gi|119392081 complement factor I preproprotein [Homo sapiens]
Length = 583
Score = 60.1 bits (144), Expect = 3e-09
Identities = 31/72 (43%), Positives = 39/72 (54%), Gaps = 5/72 (6%)
Query: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGF 94
F C NG+ I CDG+ DC D+SDE C + K F C SG+ CI +++CNG
Sbjct: 227 FQCVNGKYISQMKACDGINDCGDQSDELCCKACQGK----GFHCKSGV-CIPSQYQCNGE 281
Query: 95 EDCPDGSDEENC 106
DC G DE C
Sbjct: 282 VDCITGEDEVGC 293
Score = 57.0 bits (136), Expect = 2e-08
Identities = 28/73 (38%), Positives = 38/73 (52%), Gaps = 5/73 (6%)
Query: 75 FFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDG 134
FF C +G + I C+G DC D SDE C A C +HCK+G+CI + C+G
Sbjct: 226 FFQCVNGKY-ISQMKACDGINDCGDQSDELCCKA----CQGKGFHCKSGVCIPSQYQCNG 280
Query: 135 QNNCQDNSDEESC 147
+ +C DE C
Sbjct: 281 EVDCITGEDEVGC 293
Score = 37.7 bits (86), Expect = 0.015
Identities = 22/71 (30%), Positives = 32/71 (45%), Gaps = 3/71 (4%)
Query: 84 CIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSD 143
C + R G++D D +P+ + C NG I + CDG N+C D SD
Sbjct: 196 CTFTKRRTMGYQDFADVVCYTQKADSPM---DDFFQCVNGKYISQMKACDGINDCGDQSD 252
Query: 144 EESCESSQEPG 154
E C++ Q G
Sbjct: 253 ELCCKACQGKG 263
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,490,264
Number of Sequences: 37866
Number of extensions: 842604
Number of successful extensions: 5081
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 95
Number of HSP's successfully gapped in prelim test: 168
Number of HSP's that attempted gapping in prelim test: 3976
Number of HSP's gapped (non-prelim): 792
length of query: 345
length of database: 18,247,518
effective HSP length: 103
effective length of query: 242
effective length of database: 14,347,320
effective search space: 3472051440
effective search space used: 3472051440
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.