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Search of human proteins with 27894339
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|27894339 keratin 23 [Homo sapiens]
(422 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|27894339 keratin 23 [Homo sapiens] 843 0.0
gi|24234699 keratin 19 [Homo sapiens] 320 2e-87
gi|4557701 keratin 17 [Homo sapiens] 319 3e-87
gi|24430190 keratin 15 [Homo sapiens] 319 3e-87
gi|4557699 keratin 12 [Homo sapiens] 319 3e-87
gi|24430192 keratin 16 [Homo sapiens] 317 2e-86
gi|27894337 keratin 20 [Homo sapiens] 312 3e-85
gi|15431310 keratin 14 [Homo sapiens] 311 9e-85
gi|131412225 keratin 13 isoform a [Homo sapiens] 308 5e-84
gi|131412228 keratin 13 isoform b [Homo sapiens] 308 8e-84
gi|195972866 keratin 10 [Homo sapiens] 290 1e-78
gi|4504927 keratin 36 [Homo sapiens] 289 4e-78
gi|94538345 keratin 35 [Homo sapiens] 289 4e-78
gi|192807292 keratin 24 [Homo sapiens] 288 8e-78
gi|114431246 keratin 25D [Homo sapiens] 286 2e-77
gi|153945736 keratin 27 [Homo sapiens] 284 9e-77
gi|55956899 keratin 9 [Homo sapiens] 274 1e-73
gi|31559829 keratin 25 [Homo sapiens] 270 2e-72
gi|116488398 keratin 32 [Homo sapiens] 269 4e-72
gi|31559815 keratin 26 [Homo sapiens] 269 4e-72
gi|14917117 keratin 33A [Homo sapiens] 268 7e-72
gi|14917115 keratin 31 [Homo sapiens] 267 2e-71
gi|10337581 type I hair keratin 3B [Homo sapiens] 264 1e-70
gi|14917119 keratin 34 [Homo sapiens] 263 2e-70
gi|40354195 keratin 18 [Homo sapiens] 255 6e-68
gi|4557888 keratin 18 [Homo sapiens] 255 6e-68
gi|15431318 keratin 38 [Homo sapiens] 246 3e-65
gi|55770882 keratin 37 [Homo sapiens] 246 3e-65
gi|125490370 type I hair keratin KA36 [Homo sapiens] 240 2e-63
gi|148277620 type I hair keratin KA35 [Homo sapiens] 225 7e-59
>gi|27894339 keratin 23 [Homo sapiens]
Length = 422
Score = 843 bits (2178), Expect = 0.0
Identities = 422/422 (100%), Positives = 422/422 (100%)
Query: 1 MNSGHSFSQTPSASFHGAGGGWGRPRSFPRAPTVHGGAGGARISLSFTTRSCPPPGGSWG 60
MNSGHSFSQTPSASFHGAGGGWGRPRSFPRAPTVHGGAGGARISLSFTTRSCPPPGGSWG
Sbjct: 1 MNSGHSFSQTPSASFHGAGGGWGRPRSFPRAPTVHGGAGGARISLSFTTRSCPPPGGSWG 60
Query: 61 SGRSSPLLGGNGKATMQNLNDRLASYLEKVRALEEANMKLESRILKWHQQRDPGSKKDYS 120
SGRSSPLLGGNGKATMQNLNDRLASYLEKVRALEEANMKLESRILKWHQQRDPGSKKDYS
Sbjct: 61 SGRSSPLLGGNGKATMQNLNDRLASYLEKVRALEEANMKLESRILKWHQQRDPGSKKDYS 120
Query: 121 QYEENITHLQEQIVDGKMTNAQIILLIDNARMAVDDFNLKYENEHSFKKDLEIEVEGLRR 180
QYEENITHLQEQIVDGKMTNAQIILLIDNARMAVDDFNLKYENEHSFKKDLEIEVEGLRR
Sbjct: 121 QYEENITHLQEQIVDGKMTNAQIILLIDNARMAVDDFNLKYENEHSFKKDLEIEVEGLRR 180
Query: 181 TLDNLTIVTTDLEQEVEGMRKELILMKKHHEQEMEKHHVPSDFNVNVKVDTGPREDLIKV 240
TLDNLTIVTTDLEQEVEGMRKELILMKKHHEQEMEKHHVPSDFNVNVKVDTGPREDLIKV
Sbjct: 181 TLDNLTIVTTDLEQEVEGMRKELILMKKHHEQEMEKHHVPSDFNVNVKVDTGPREDLIKV 240
Query: 241 LEDMRQEYELIIKKKHRDLDTWYKEQSAAMSQEAASPATVQSRQGDIHELKRTFQALEID 300
LEDMRQEYELIIKKKHRDLDTWYKEQSAAMSQEAASPATVQSRQGDIHELKRTFQALEID
Sbjct: 241 LEDMRQEYELIIKKKHRDLDTWYKEQSAAMSQEAASPATVQSRQGDIHELKRTFQALEID 300
Query: 301 LQTQYSTKSALENMLSETQSRYSCKLQDMQEIISHYEEELTQLRHELERQNNEYQVLLGI 360
LQTQYSTKSALENMLSETQSRYSCKLQDMQEIISHYEEELTQLRHELERQNNEYQVLLGI
Sbjct: 301 LQTQYSTKSALENMLSETQSRYSCKLQDMQEIISHYEEELTQLRHELERQNNEYQVLLGI 360
Query: 361 KTHLEKEITTYRRLLEGESEGTREESKSSMKVSATPKIKAITQETINGRLVLCQVNEIQK 420
KTHLEKEITTYRRLLEGESEGTREESKSSMKVSATPKIKAITQETINGRLVLCQVNEIQK
Sbjct: 361 KTHLEKEITTYRRLLEGESEGTREESKSSMKVSATPKIKAITQETINGRLVLCQVNEIQK 420
Query: 421 HA 422
HA
Sbjct: 421 HA 422
>gi|24234699 keratin 19 [Homo sapiens]
Length = 400
Score = 320 bits (819), Expect = 2e-87
Identities = 169/398 (42%), Positives = 257/398 (64%), Gaps = 10/398 (2%)
Query: 3 SGHSFSQTPS-ASFHGAGGGWGR--PRSFPRAPTVHGGAGGARISLSFTTRSCPPPGGSW 59
+ +S+ Q+ + +SF G GGG R P RAP++HGG+GG +S+S G++
Sbjct: 2 TSYSYRQSSATSSFGGLGGGSVRFGPGVAFRAPSIHGGSGGRGVSVSSARFVSSSSSGAY 61
Query: 60 GSG------RSSPLLGGNGKATMQNLNDRLASYLEKVRALEEANMKLESRILKWHQQRDP 113
G G S LL GN K TMQNLNDRLASYL+KVRALE AN +LE +I W+Q++ P
Sbjct: 62 GGGYGGVLTASDGLLAGNEKLTMQNLNDRLASYLDKVRALEAANGELEVKIRDWYQKQGP 121
Query: 114 GSKKDYSQYEENITHLQEQIVDGKMTNAQIILLIDNARMAVDDFNLKYENEHSFKKDLEI 173
G +DYS Y I L+++I+ + N++I+L IDNAR+A DDF K+E E + + +E
Sbjct: 122 GPSRDYSHYYTTIQDLRDKILGATIENSRIVLQIDNARLAADDFRTKFETEQALRMSVEA 181
Query: 174 EVEGLRRTLDNLTIVTTDLEQEVEGMRKELILMKKHHEQEMEKHHVPSDFNVNVKVDTGP 233
++ GLRR LD LT+ TDLE ++EG+++EL +KK+HE+E+ V+V+VD+ P
Sbjct: 182 DINGLRRVLDELTLARTDLEMQIEGLKEELAYLKKNHEEEISTLRGQVGGQVSVEVDSAP 241
Query: 234 REDLIKVLEDMRQEYELIIKKKHRDLDTWYKEQSAAMSQEAAS-PATVQSRQGDIHELKR 292
DL K+L DMR +YE++ ++ +D + W+ ++ +++E A +Q + ++ +L+R
Sbjct: 242 GTDLAKILSDMRSQYEVMAEQNRKDAEAWFTSRTEELNREVAGHTEQLQMSRSEVTDLRR 301
Query: 293 TFQALEIDLQTQYSTKSALENMLSETQSRYSCKLQDMQEIISHYEEELTQLRHELERQNN 352
T Q LEI+LQ+Q S K+ALE+ L+ET++R+ +L +Q +IS E +L +R + ERQN
Sbjct: 302 TLQGLEIELQSQLSMKAALEDTLAETEARFGAQLAHIQALISGIEAQLGDVRADSERQNQ 361
Query: 353 EYQVLLGIKTHLEKEITTYRRLLEGESEGTREESKSSM 390
EYQ L+ IK+ LE+EI TYR LLEG+ + S S +
Sbjct: 362 EYQRLMDIKSRLEQEIATYRSLLEGQEDHYNNLSASKV 399
>gi|4557701 keratin 17 [Homo sapiens]
Length = 432
Score = 319 bits (818), Expect = 3e-87
Identities = 167/379 (44%), Positives = 247/379 (65%), Gaps = 6/379 (1%)
Query: 36 GGAGGARISLSFTTRSCPPPGGSWGS--GRSSPLLGGNGKATMQNLNDRLASYLEKVRAL 93
GG G S+++ GG +GS G LL G KATMQNLNDRLASYL+KVRAL
Sbjct: 46 GGLGSTLGGSSYSSCYSFGSGGGYGSSFGGVDGLLAGGEKATMQNLNDRLASYLDKVRAL 105
Query: 94 EEANMKLESRILKWHQQRDPGSKKDYSQYEENITHLQEQIVDGKMTNAQIILLIDNARMA 153
EEAN +LE +I W+Q++ PG +DYSQY I LQ +I+ + NA I+L IDNAR+A
Sbjct: 106 EEANTELEVKIRDWYQRQAPGPARDYSQYYRTIEELQNKILTATVDNANILLQIDNARLA 165
Query: 154 VDDFNLKYENEHSFKKDLEIEVEGLRRTLDNLTIVTTDLEQEVEGMRKELILMKKHHEQE 213
DDF K+E E + + +E ++ GLRR LD LT+ DLE ++E +++EL +KK+HE+E
Sbjct: 166 ADDFRTKFETEQALRLSVEADINGLRRVLDELTLARADLEMQIENLKEELAYLKKNHEEE 225
Query: 214 MEKHHVPSDFNVNVKVDTGPREDLIKVLEDMRQEYELIIKKKHRDLDTWYKEQSAAMSQE 273
M +NV++D P DL ++L +MR +YE + +K +D + W+ ++ +++E
Sbjct: 226 MNALRGQVGGEINVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEDWFFSKTEELNRE 285
Query: 274 AASPA-TVQSRQGDIHELKRTFQALEIDLQTQYSTKSALENMLSETQSRYSCKLQDMQEI 332
A+ + VQS + +I EL+RT QALEI+LQ+Q S K++LE L+ET++RY +L +Q +
Sbjct: 286 VATNSELVQSGKSEISELRRTMQALEIELQSQLSMKASLEGNLAETENRYCVQLSQIQGL 345
Query: 333 ISHYEEELTQLRHELERQNNEYQVLLGIKTHLEKEITTYRRLLEGESEGTREESKSSMKV 392
I EE+L QLR E+E+QN EY++LL +KT LE+EI TYRRLLEGE + K +
Sbjct: 346 IGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLTQYKKEPV-- 403
Query: 393 SATPKIKAITQETINGRLV 411
T +++ I +E +G+++
Sbjct: 404 -TTRQVRTIVEEVQDGKVI 421
>gi|24430190 keratin 15 [Homo sapiens]
Length = 456
Score = 319 bits (817), Expect = 3e-87
Identities = 189/432 (43%), Positives = 274/432 (63%), Gaps = 27/432 (6%)
Query: 3 SGHSFSQTPSASF-----HGAGGGWG---RPRSFPR-APTVHGGAGGARISLSFTTRSCP 53
SG S++ SAS G+GGG+G R F A +V GG G + F
Sbjct: 36 SGGGGSRSISASSARFVSSGSGGGYGGGMRVCGFGGGAGSVFGGGFGGGVGGGF------ 89
Query: 54 PPGGSWGSGRSSPLLGGNGKATMQNLNDRLASYLEKVRALEEANMKLESRILKWHQQRDP 113
GG +G G LL GN K TMQNLNDRLASYL+KVRALEEAN LE +I W+Q++ P
Sbjct: 90 --GGGFGGGDGG-LLSGNEKITMQNLNDRLASYLDKVRALEEANADLEVKIHDWYQKQTP 146
Query: 114 GSKK-DYSQYEENITHLQEQIVDGKMTNAQIILLIDNARMAVDDFNLKYENEHSFKKDLE 172
S + DYSQY + I L+++I+ + N+++IL IDNAR+A DDF LKYENE + ++ +E
Sbjct: 147 TSPECDYSQYFKTIEELRDKIMATTIDNSRVILEIDNARLAADDFRLKYENELALRQGVE 206
Query: 173 IEVEGLRRTLDNLTIVTTDLEQEVEGMRKELILMKKHHEQEMEKHHVPSDFNVNVKVDTG 232
++ GLRR LD LT+ TDLE ++EG+ +EL +KK+HE+EM++ VNV++D
Sbjct: 207 ADINGLRRVLDELTLARTDLEMQIEGLNEELAYLKKNHEEEMKEFSSQLAGQVNVEMDAA 266
Query: 233 PREDLIKVLEDMRQEYELIIKKKHRDLDTWYKEQSAAMSQEAAS-PATVQSRQGDIHELK 291
P DL +VL +MR++YE + +K RD++ W+ ++ +++E AS +Q+ + +I +L+
Sbjct: 267 PGVDLTRVLAEMREQYEAMAEKNRRDVEAWFFSKTEELNKEVASNTEMIQTSKTEITDLR 326
Query: 292 RTFQALEIDLQTQYSTKSALENMLSETQSRYSCKLQDMQEIISHYEEELTQLRHELERQN 351
RT Q LEI+LQ+Q S K+ LEN L+ET+ RY+ +LQ +Q +I E +L++LR E+E QN
Sbjct: 327 RTMQELEIELQSQLSMKAGLENSLAETECRYATQLQQIQGLIGGLEAQLSELRCEMEAQN 386
Query: 352 NEYQVLLGIKTHLEKEITTYRRLLEGESE-----GTREESKSSMKVSATPKIKAITQETI 406
EY++LL IKT LE+EI TYR LLEG+ G RE S S+ I +E++
Sbjct: 387 QEYKMLLDIKTRLEQEIATYRSLLEGQDAKMAGIGIREASSGGGGSSSNFHIN--VEESV 444
Query: 407 NGRLVLCQVNEI 418
+G++V EI
Sbjct: 445 DGQVVSSHKREI 456
>gi|4557699 keratin 12 [Homo sapiens]
Length = 494
Score = 319 bits (817), Expect = 3e-87
Identities = 178/434 (41%), Positives = 266/434 (61%), Gaps = 25/434 (5%)
Query: 12 SASFHGAGGGWGRPRSFPRAPTVHGGAGGARISLSFTTRSC----PPPGGSWG--SGRSS 65
+AS G+ G+G A + G G A SF P GGS G SG
Sbjct: 59 AASMFGSSSGFGGGSGSSMAGGLGAGYGRALGGGSFGGLGMGFGGSPGGGSLGILSGNDG 118
Query: 66 PLLGGNGKATMQNLNDRLASYLEKVRALEEANMKLESRILKWHQQRDPG----SKKDYSQ 121
LL G+ K TMQNLNDRLASYL+KVRALEEAN +LE++I +W++ R G S+ DYS+
Sbjct: 119 GLLSGSEKETMQNLNDRLASYLDKVRALEEANTELENKIREWYETRGTGTADASQSDYSK 178
Query: 122 YEENITHLQEQIVDGKMTNAQIILLIDNARMAVDDFNLKYENEHSFKKDLEIEVEGLRRT 181
Y I L+ +I+ + NAQ++L IDNAR+A +DF +KYENE + ++ +E ++ GLRR
Sbjct: 179 YYPLIEDLRNKIISASIGNAQLLLQIDNARLAAEDFRMKYENELALRQGVEADINGLRRV 238
Query: 182 LDNLTIVTTDLEQEVEGMRKELILMKKHHEQEMEKHHVPSDFNVNVKVDTGPREDLIKVL 241
LD LT+ TDLE ++E + +EL MKK+HE E++ V V+V++D P DL ++L
Sbjct: 239 LDELTLTRTDLEMQIESLNEELAYMKKNHEDELQSFRVGGPGEVSVEMDAAPGVDLTRLL 298
Query: 242 EDMRQEYELIIKKKHRDLDTWYKEQSAAMSQE-AASPATVQSRQGDIHELKRTFQALEID 300
DMR +YE I ++ +D + W+ E+S + +E + + +QS + ++ +L+R FQ LEI+
Sbjct: 299 NDMRAQYETIAEQNRKDAEAWFIEKSGELRKEISTNTEQLQSSKSEVTDLRRAFQNLEIE 358
Query: 301 LQTQYSTKSALENMLSETQSRYSCKLQDMQEIISHYEEELTQLRHELERQNNEYQVLLGI 360
LQ+Q + K +LE+ L+E + Y +L +Q++IS+ E +L Q+R + ERQN ++Q LL +
Sbjct: 359 LQSQLAMKKSLEDSLAEAEGDYCAQLSQVQQLISNLEAQLLQVRADAERQNVDHQRLLNV 418
Query: 361 KTHLEKEITTYRRLLEGESEG--------------TREESKSSMKVSATPKIKAITQETI 406
K LE EI TYRRLL+GE++G + + SS + T KIK + QE +
Sbjct: 419 KARLELEIETYRRLLDGEAQGDGLEESLFVTDSKSQAQSTDSSKDPTKTRKIKTVVQEMV 478
Query: 407 NGRLVLCQVNEIQK 420
NG +V QV EI++
Sbjct: 479 NGEVVSSQVQEIEE 492
>gi|24430192 keratin 16 [Homo sapiens]
Length = 473
Score = 317 bits (811), Expect = 2e-86
Identities = 172/385 (44%), Positives = 242/385 (62%), Gaps = 18/385 (4%)
Query: 17 GAGGGWGRPRSFPRAPTVHGGAGGARISLSFTTRSCPPPGGSWGSGRSSPLLGGNG---- 72
G GGG+ SF GG G + F GG G+G GG+G
Sbjct: 67 GYGGGFSSSSSFGSG---FGGGYGGGLGAGF--------GGGLGAGFGGGFAGGDGLLVG 115
Query: 73 --KATMQNLNDRLASYLEKVRALEEANMKLESRILKWHQQRDPGSKKDYSQYEENITHLQ 130
K TMQNLNDRLASYL+KVRALEEAN LE +I W+Q++ P KDYS Y + I L+
Sbjct: 116 SEKVTMQNLNDRLASYLDKVRALEEANADLEVKIRDWYQRQRPSEIKDYSPYFKTIEDLR 175
Query: 131 EQIVDGKMTNAQIILLIDNARMAVDDFNLKYENEHSFKKDLEIEVEGLRRTLDNLTIVTT 190
+I+ + NAQ IL IDNAR+A DDF KYE+E + ++ +E +V GLRR LD LT+ T
Sbjct: 176 NKIIAATIENAQPILQIDNARLAADDFRTKYEHELALRQTVEADVNGLRRVLDELTLART 235
Query: 191 DLEQEVEGMRKELILMKKHHEQEMEKHHVPSDFNVNVKVDTGPREDLIKVLEDMRQEYEL 250
DLE ++EG+++EL ++K+HE+EM + +VNV++D P DL ++L +MR +YE
Sbjct: 236 DLEMQIEGLKEELAYLRKNHEEEMLALRGQTGGDVNVEMDAAPGVDLSRILNEMRDQYEQ 295
Query: 251 IIKKKHRDLDTWYKEQSAAMSQEAASPA-TVQSRQGDIHELKRTFQALEIDLQTQYSTKS 309
+ +K RD +TW+ ++ +++E AS + VQS + ++ EL+R Q LEI+LQ+Q S K+
Sbjct: 296 MAEKNRRDAETWFLSKTEELNKEVASNSELVQSSRSEVTELRRVLQGLEIELQSQLSMKA 355
Query: 310 ALENMLSETQSRYSCKLQDMQEIISHYEEELTQLRHELERQNNEYQVLLGIKTHLEKEIT 369
+LEN L ET+ RY +L +Q +I EE+L QLR E+E+Q+ EYQ+LL +KT LE+EI
Sbjct: 356 SLENSLEETKGRYCMQLSQIQGLIGSVEEQLAQLRCEMEQQSQEYQILLDVKTRLEQEIA 415
Query: 370 TYRRLLEGESEGTREESKSSMKVSA 394
TYRRLLEGE + S S+
Sbjct: 416 TYRRLLEGEDAHLSSQQASGQSYSS 440
>gi|27894337 keratin 20 [Homo sapiens]
Length = 424
Score = 312 bits (800), Expect = 3e-85
Identities = 164/394 (41%), Positives = 255/394 (64%), Gaps = 7/394 (1%)
Query: 32 PTVHGGAGGARISLSFTTRSCPPPGGSWGSGRSSPLLGGNGKATMQNLNDRLASYLEKVR 91
P+V+GGAGG I +S + + G G L GN K MQNLNDRLASYLEKVR
Sbjct: 33 PSVYGGAGGRGIRISNSRHTVNYGSDLTGGG---DLFVGNEKMAMQNLNDRLASYLEKVR 89
Query: 92 ALEEANMKLESRILKWHQQRDPGSKKDYSQYEENITHLQEQIVDGKMTNAQIILLIDNAR 151
LE++N KLE +I +W++ P + +DYS Y I L+ QI D ++ NA+ +L IDNA+
Sbjct: 90 TLEQSNSKLEVQIKQWYETNAPRAGRDYSAYYRQIEELRSQIKDAQLQNARCVLQIDNAK 149
Query: 152 MAVDDFNLKYENEHSFKKDLEIEVEGLRRTLDNLTIVTTDLEQEVEGMRKELILMKKHHE 211
+A +DF LKYE E + +E +++GL + D+LT+ TDLE ++E + K+L L+KK H+
Sbjct: 150 LAAEDFRLKYETERGIRLTVEADLQGLNKVFDDLTLHKTDLEIQIEELNKDLALLKKEHQ 209
Query: 212 QEMEKHHVPSDFNVNVKVDTGPREDLIKVLEDMRQEYELIIKKKHRDLDTWYKEQSAAMS 271
+E++ H VNV+VD P +L ++ +MRQ+YE++ +K ++ ++ Q+A +
Sbjct: 210 EEVDGLHKHLGNTVNVEVDAAPGLNLGVIMNEMRQKYEVMAQKNLQEAKEQFERQTAVLQ 269
Query: 272 QE-AASPATVQSRQGDIHELKRTFQALEIDLQTQYSTKSALENMLSETQSRYSCKLQDMQ 330
Q+ + ++ + + EL+RT Q+LEI+LQ+ S K +LE+ L ET++RYS +L ++Q
Sbjct: 270 QQVTVNTEELKGTEVQLTELRRTSQSLEIELQSHLSMKESLEHTLEETKARYSSQLANLQ 329
Query: 331 EIISHYEEELTQLRHELERQNNEYQVLLGIKTHLEKEITTYRRLLEGESEGTREESKSSM 390
++S E +L Q+R +ERQNNEY +LL IKT LE+EI TYRRLLEGE T E S++
Sbjct: 330 SLLSSLEAQLMQIRSNMERQNNEYHILLDIKTRLEQEIATYRRLLEGEDVKTTEYQLSTL 389
Query: 391 K---VSATPKIKAITQETINGRLVLCQVNEIQKH 421
+ + T KIK + QE ++G++V +V E++++
Sbjct: 390 EERDIKKTRKIKTVVQEVVDGKVVSSEVKEVEEN 423
>gi|15431310 keratin 14 [Homo sapiens]
Length = 472
Score = 311 bits (796), Expect = 9e-85
Identities = 178/415 (42%), Positives = 258/415 (62%), Gaps = 15/415 (3%)
Query: 6 SFSQTPSASFHGAGGGWGRPRSFPRAPTVHGGAGGARISLSFTTRSCPPPGGSWGSGRSS 65
S S+ S +G GGG+G S + G GG L GG +G G +
Sbjct: 53 SSSRFSSGGAYGLGGGYGGGFSSSSSSFGSGFGGGYGGGLGAGL------GGGFGGGFAG 106
Query: 66 P--LLGGNGKATMQNLNDRLASYLEKVRALEEANMKLESRILKWHQQRDPGSKKDYSQYE 123
LL G+ K TMQNLNDRLASYL+KVRALEEAN LE +I W+Q++ P KDYS Y
Sbjct: 107 GDGLLVGSEKVTMQNLNDRLASYLDKVRALEEANADLEVKIRDWYQRQRPAEIKDYSPYF 166
Query: 124 ENITHLQEQIVDGKMTNAQIILLIDNARMAVDDFNLKYENEHSFKKDLEIEVEGLRRTLD 183
+ I L+ +I+ + NA ++L IDNAR+A DDF KYE E + + +E ++ GLRR LD
Sbjct: 167 KTIEDLRNKILTATVDNANVLLQIDNARLAADDFRTKYETELNLRMSVEADINGLRRVLD 226
Query: 184 NLTIVTTDLEQEVEGMRKELILMKKHHEQEMEKHHVPSDFNVNVKVDTGPREDLIKVLED 243
LT+ DLE ++E +++EL +KK+HE+EM +VNV++D P DL ++L +
Sbjct: 227 ELTLARADLEMQIESLKEELAYLKKNHEEEMNALRGQVGGDVNVEMDAAPGVDLSRILNE 286
Query: 244 MRQEYELIIKKKHRDLDTWYKEQSAAMSQEAASPA-TVQSRQGDIHELKRTFQALEIDLQ 302
MR +YE + +K +D + W+ ++ +++E A+ + VQS + +I EL+RT Q LEI+LQ
Sbjct: 287 MRDQYEKMAEKNRKDAEEWFFTKTEELNREVATNSELVQSGKSEISELRRTMQNLEIELQ 346
Query: 303 TQYSTKSALENMLSETQSRYSCKLQDMQEIISHYEEELTQLRHELERQNNEYQVLLGIKT 362
+Q S K++LEN L ET+ RY +L +QE+I EE+L QLR E+E+QN EY++LL +KT
Sbjct: 347 SQLSMKASLENSLEETKGRYCMQLAQIQEMIGSVEEQLAQLRCEMEQQNQEYKILLDVKT 406
Query: 363 HLEKEITTYRRLLEGE-----SEGTREESKSSMKV-SATPKIKAITQETINGRLV 411
LE+EI TYRRLLEGE S S+SS V S++ +I+ + +G++V
Sbjct: 407 RLEQEIATYRRLLEGEDAHLSSSQFSSGSQSSRDVTSSSRQIRTKVMDVHDGKVV 461
>gi|131412225 keratin 13 isoform a [Homo sapiens]
Length = 458
Score = 308 bits (790), Expect = 5e-84
Identities = 175/402 (43%), Positives = 249/402 (61%), Gaps = 20/402 (4%)
Query: 17 GAGGGWGRPRSFPRAPTVHGGAGGARISLSFTTRSCPPPGGSWGSGRSSPLLGGNGKATM 76
G GGG+G + GG GG +C GG LL GN K TM
Sbjct: 60 GFGGGYGGGLGGGYGGGLGGGFGGGFAGGFVDFGACD--GG---------LLTGNEKITM 108
Query: 77 QNLNDRLASYLEKVRALEEANMKLESRILKWHQQRDPGS-KKDYSQYEENITHLQEQIVD 135
QNLNDRLASYLEKVRALEEAN LE +I WH ++ P S ++DYS Y + I L+++I+
Sbjct: 109 QNLNDRLASYLEKVRALEEANADLEVKIRDWHLKQSPASPERDYSPYYKTIEELRDKILT 168
Query: 136 GKMTNAQIILLIDNARMAVDDFNLKYENEHSFKKDLEIEVEGLRRTLDNLTIVTTDLEQE 195
+ N ++IL IDNAR+A DDF LKYENE + ++ +E ++ GLRR LD LT+ TDLE +
Sbjct: 169 ATIENNRVILEIDNARLAADDFRLKYENELALRQSVEADINGLRRVLDELTLSKTDLEMQ 228
Query: 196 VEGMRKELILMKKHHEQEMEKHHVPSDFNVNVKVDTGPREDLIKVLEDMRQEYELIIKKK 255
+E + +EL MKK+HE+EM++ VNV++D P DL +VL +MR++YE + ++
Sbjct: 229 IESLNEELAYMKKNHEEEMKEFSNQVVGQVNVEMDATPGIDLTRVLAEMREQYEAMAERN 288
Query: 256 HRDLDTWYKEQSAAMSQE-AASPATVQSRQGDIHELKRTFQALEIDLQTQYSTKSALENM 314
RD + W+ +SA +++E + + A +Q+ + +I EL+RT Q LEI+LQ+Q S K+ LEN
Sbjct: 289 RRDAEEWFHAKSAELNKEVSTNTAMIQTSKTEITELRRTLQGLEIELQSQLSMKAGLENT 348
Query: 315 LSETQSRYSCKLQDMQEIISHYEEELTQLRHELERQNNEYQVLLGIKTHLEKEITTYRRL 374
++ET+ RY+ +LQ +Q +IS E +L++LR E+E QN EY++LL IKT LE+EI TYR L
Sbjct: 349 VAETECRYALQLQQIQGLISSIEAQLSELRSEMECQNQEYKMLLDIKTRLEQEIATYRSL 408
Query: 375 LEGES-------EGTREESKSSMKVSATPKIKAITQETINGR 409
LEG+ S S V+ T T +GR
Sbjct: 409 LEGQDAKMIGFPSSAGSVSPRSTSVTTTSSASVTTTSNASGR 450
>gi|131412228 keratin 13 isoform b [Homo sapiens]
Length = 420
Score = 308 bits (788), Expect = 8e-84
Identities = 169/370 (45%), Positives = 242/370 (65%), Gaps = 13/370 (3%)
Query: 17 GAGGGWGRPRSFPRAPTVHGGAGGARISLSFTTRSCPPPGGSWGSGRSSPLLGGNGKATM 76
G GGG+G + GG GG +C GG LL GN K TM
Sbjct: 60 GFGGGYGGGLGGGYGGGLGGGFGGGFAGGFVDFGACD--GG---------LLTGNEKITM 108
Query: 77 QNLNDRLASYLEKVRALEEANMKLESRILKWHQQRDPGS-KKDYSQYEENITHLQEQIVD 135
QNLNDRLASYLEKVRALEEAN LE +I WH ++ P S ++DYS Y + I L+++I+
Sbjct: 109 QNLNDRLASYLEKVRALEEANADLEVKIRDWHLKQSPASPERDYSPYYKTIEELRDKILT 168
Query: 136 GKMTNAQIILLIDNARMAVDDFNLKYENEHSFKKDLEIEVEGLRRTLDNLTIVTTDLEQE 195
+ N ++IL IDNAR+A DDF LKYENE + ++ +E ++ GLRR LD LT+ TDLE +
Sbjct: 169 ATIENNRVILEIDNARLAADDFRLKYENELALRQSVEADINGLRRVLDELTLSKTDLEMQ 228
Query: 196 VEGMRKELILMKKHHEQEMEKHHVPSDFNVNVKVDTGPREDLIKVLEDMRQEYELIIKKK 255
+E + +EL MKK+HE+EM++ VNV++D P DL +VL +MR++YE + ++
Sbjct: 229 IESLNEELAYMKKNHEEEMKEFSNQVVGQVNVEMDATPGIDLTRVLAEMREQYEAMAERN 288
Query: 256 HRDLDTWYKEQSAAMSQE-AASPATVQSRQGDIHELKRTFQALEIDLQTQYSTKSALENM 314
RD + W+ +SA +++E + + A +Q+ + +I EL+RT Q LEI+LQ+Q S K+ LEN
Sbjct: 289 RRDAEEWFHAKSAELNKEVSTNTAMIQTSKTEITELRRTLQGLEIELQSQLSMKAGLENT 348
Query: 315 LSETQSRYSCKLQDMQEIISHYEEELTQLRHELERQNNEYQVLLGIKTHLEKEITTYRRL 374
++ET+ RY+ +LQ +Q +IS E +L++LR E+E QN EY++LL IKT LE+EI TYR L
Sbjct: 349 VAETECRYALQLQQIQGLISSIEAQLSELRSEMECQNQEYKMLLDIKTRLEQEIATYRSL 408
Query: 375 LEGESEGTRE 384
LEG+ R+
Sbjct: 409 LEGQDAKKRQ 418
>gi|195972866 keratin 10 [Homo sapiens]
Length = 584
Score = 290 bits (743), Expect = 1e-78
Identities = 167/377 (44%), Positives = 231/377 (61%), Gaps = 17/377 (4%)
Query: 6 SFSQTPSASFHGAGGGWGRPRSFPRAPTVHGGAGGARISLSFTTRSCPPPGGSWGSGRSS 65
SF + SF G G G SF GG GG F GG G G
Sbjct: 93 SFGGSYGGSFGGGSFGGG---SFGGGSFGGGGFGGGGFGGGF--------GG--GFGGDG 139
Query: 66 PLLGGNGKATMQNLNDRLASYLEKVRALEEANMKLESRILKWHQQRD---PGSKKDYSQY 122
LL GN K TMQNLNDRLASYL+KVRALEE+N +LE +I +W+++ G +DYS+Y
Sbjct: 140 GLLSGNEKVTMQNLNDRLASYLDKVRALEESNYELEGKIKEWYEKHGNSHQGEPRDYSKY 199
Query: 123 EENITHLQEQIVDGKMTNAQIILLIDNARMAVDDFNLKYENEHSFKKDLEIEVEGLRRTL 182
+ I L+ QI++ NA I+L IDNAR+A DDF LKYENE + ++ +E ++ GLRR L
Sbjct: 200 YKTIDDLKNQILNLTTDNANILLQIDNARLAADDFRLKYENEVALRQSVEADINGLRRVL 259
Query: 183 DNLTIVTTDLEQEVEGMRKELILMKKHHEQEMEKHHVPSDFNVNVKVDTGPREDLIKVLE 242
D LT+ DLE ++E + +EL +KK+HE+EM+ S +VNV+++ P DL ++L
Sbjct: 260 DELTLTKADLEMQIESLTEELAYLKKNHEEEMKDLRNVSTGDVNVEMNAAPGVDLTQLLN 319
Query: 243 DMRQEYELIIKKKHRDLDTWYKEQSAAMSQEAASP-ATVQSRQGDIHELKRTFQALEIDL 301
+MR +YE + ++ +D + W+ E+S ++ E + + S + +I EL+R QALEI+L
Sbjct: 320 NMRSQYEQLAEQNRKDAEAWFNEKSKELTTEIDNNIEQISSYKSEITELRRNVQALEIEL 379
Query: 302 QTQYSTKSALENMLSETQSRYSCKLQDMQEIISHYEEELTQLRHELERQNNEYQVLLGIK 361
Q+Q + K +LE L+ET+ RY +L +Q IS EE+L Q+R E E QN EYQ LL IK
Sbjct: 380 QSQLALKQSLEASLAETEGRYCVQLSQIQAQISALEEQLQQIRAETECQNTEYQQLLDIK 439
Query: 362 THLEKEITTYRRLLEGE 378
LE EI TYR LLEGE
Sbjct: 440 IRLENEIQTYRSLLEGE 456
>gi|4504927 keratin 36 [Homo sapiens]
Length = 467
Score = 289 bits (739), Expect = 4e-78
Identities = 166/395 (42%), Positives = 240/395 (60%), Gaps = 25/395 (6%)
Query: 6 SFSQTPSASFHGAGGGWGRPRSFP-----RAPTVHGGAG------------GARISLSFT 48
+FS G GG R S R P++ G AG G+ + S+
Sbjct: 9 TFSTGSIKGLCGTAGGISRVSSIRSVGSCRVPSLAGAAGYISSARSGLSGLGSCLPGSYL 68
Query: 49 TRSCPPPG----GSWGSGRSSPLLGGNGKATMQNLNDRLASYLEKVRALEEANMKLESRI 104
+ C G G W S G+ K TMQ LNDRLA+YLEKVR LE N +LESRI
Sbjct: 69 SSECHTSGFVGSGGWFCEGS---FNGSEKETMQFLNDRLANYLEKVRQLERENAELESRI 125
Query: 105 LKWHQQRDPGSKKDYSQYEENITHLQEQIVDGKMTNAQIILLIDNARMAVDDFNLKYENE 164
+W++ + P DY Y + I Q++I+ K NA+++L IDNA++A DDF KYE E
Sbjct: 126 QEWYEFQIPYICPDYQSYFKTIEDFQQKILLTKSENARLVLQIDNAKLAADDFRTKYETE 185
Query: 165 HSFKKDLEIEVEGLRRTLDNLTIVTTDLEQEVEGMRKELILMKKHHEQEMEKHHVPSDFN 224
S ++ +E ++ GLRR LD LT+ DLE +VE +++EL+ +KK+HE+E+
Sbjct: 186 LSLRQLVEADINGLRRILDELTLCKADLEAQVESLKEELMCLKKNHEEEVSVLRCQLGDR 245
Query: 225 VNVKVDTGPREDLIKVLEDMRQEYELIIKKKHRDLDTWYKEQSAAMSQEAASPA-TVQSR 283
+NV+VD P DL K+LEDMR +YE +++ RD++ W+ Q+ ++Q+ S + +Q
Sbjct: 246 LNVEVDAAPPVDLNKILEDMRCQYEALVENNRRDVEAWFNTQTEELNQQVVSSSEQLQCC 305
Query: 284 QGDIHELKRTFQALEIDLQTQYSTKSALENMLSETQSRYSCKLQDMQEIISHYEEELTQL 343
Q +I EL+RT ALEI+LQ Q+S +++LE+ L+ET++RYS +L MQ +IS+ E +L+++
Sbjct: 306 QTEIIELRRTVNALEIELQAQHSMRNSLESTLAETEARYSSQLAQMQCLISNVEAQLSEI 365
Query: 344 RHELERQNNEYQVLLGIKTHLEKEITTYRRLLEGE 378
R +LERQN EYQVLL +K LE EI TYR LLEGE
Sbjct: 366 RCDLERQNQEYQVLLDVKARLEGEIATYRHLLEGE 400
>gi|94538345 keratin 35 [Homo sapiens]
Length = 455
Score = 289 bits (739), Expect = 4e-78
Identities = 165/369 (44%), Positives = 232/369 (62%), Gaps = 16/369 (4%)
Query: 14 SFHGAGGGWGRP--RSFPRAPTVHGGAGGARISLSFTTRSCPPPGGSW-GSGRSSPLLGG 70
SF G GR R+ P + AGG S S GG W G G +L G
Sbjct: 48 SFSACSVGLGRSSYRATSCLPALCLPAGGFATSYS--------GGGGWFGEG----ILTG 95
Query: 71 NGKATMQNLNDRLASYLEKVRALEEANMKLESRILKWHQQRDPGSKKDYSQYEENITHLQ 130
N K TMQ+LNDRLA YLEKVR LE+ N LESRI +W +Q+ P DY Y I LQ
Sbjct: 96 NEKETMQSLNDRLAGYLEKVRQLEQENASLESRIREWCEQQVPYMCPDYQSYFRTIEELQ 155
Query: 131 EQIVDGKMTNAQIILLIDNARMAVDDFNLKYENEHSFKKDLEIEVEGLRRTLDNLTIVTT 190
++ + K NA++++ IDNA++A DDF KYE E S ++ +E ++ GLRR LD+LT+ +
Sbjct: 156 KKTLCSKAENARLVVEIDNAKLAADDFRTKYETEVSLRQLVESDINGLRRILDDLTLCKS 215
Query: 191 DLEQEVEGMRKELILMKKHHEQEMEKHHVPSDFNVNVKVDTGPREDLIKVLEDMRQEYEL 250
DLE +VE +++EL+ +KK+HE+E+ +NV+VD P DL +VLE+MR +YE
Sbjct: 216 DLEAQVESLKEELLCLKKNHEEEVNSLRCQLGDRLNVEVDAAPPVDLNRVLEEMRCQYET 275
Query: 251 IIKKKHRDLDTWYKEQSAAMSQEAASPA-TVQSRQGDIHELKRTFQALEIDLQTQYSTKS 309
+++ RD + W QS ++Q+ S + +QS Q +I EL+RT ALEI+LQ Q+S +
Sbjct: 276 LVENNRRDAEDWLDTQSEELNQQVVSSSEQLQSCQAEIIELRRTVNALEIELQAQHSMRD 335
Query: 310 ALENMLSETQSRYSCKLQDMQEIISHYEEELTQLRHELERQNNEYQVLLGIKTHLEKEIT 369
ALE+ L+ET++RYS +L MQ +I++ E +L ++R +LERQN EYQVLL ++ LE EI
Sbjct: 336 ALESTLAETEARYSSQLAQMQCMITNVEAQLAEIRADLERQNQEYQVLLDVRARLECEIN 395
Query: 370 TYRRLLEGE 378
TYR LLE E
Sbjct: 396 TYRGLLESE 404
>gi|192807292 keratin 24 [Homo sapiens]
Length = 525
Score = 288 bits (736), Expect = 8e-78
Identities = 175/442 (39%), Positives = 252/442 (57%), Gaps = 36/442 (8%)
Query: 12 SASFHGAGGGWGRPRSFPRAPTVHGGAGGARISLSFTTRSCPPPGGSWGSGRSSPLLGGN 71
S + G G +G F R G G +R S T GG G L G
Sbjct: 83 SGTGFGGGSSFGGVSGFGRGS---GFCGSSRFSSGATGGFYSYGGGMGGGVGDGGLFSGG 139
Query: 72 GKATMQNLNDRLASYLEKVRALEEANMKLESRILKWHQQRDPGSK-----KDYSQYEENI 126
K TMQNLNDRLA+YL+KVRALEEAN LE++I +W+ + PGS +DYS+Y I
Sbjct: 140 EKQTMQNLNDRLANYLDKVRALEEANTDLENKIKEWYDKYGPGSGDGGSGRDYSKYYSII 199
Query: 127 THLQEQIVDGKMTNAQIILLIDNARMAVDDFNLKYENEHSFKKDLEIEVEGLRRTLDNLT 186
L+ QI+ + NA IIL IDNAR+A DDF LKYENE ++ +E ++ GLR+ LD+LT
Sbjct: 200 EDLRNQIIAATVENAGIILHIDNARLAADDFRLKYENELCLRQSVEADINGLRKVLDDLT 259
Query: 187 IVTTDLEQEVEGMRKELILMKKHHEQEMEKHHVPSDFNVNVKVDTGPREDLIKVLEDMRQ 246
+ +DLE ++E +EL ++K+HE+EM+ S V V+++ P DL K+L DMR
Sbjct: 260 MTRSDLEMQIESFTEELAYLRKNHEEEMKNMQGSSGGEVTVEMNAAPGTDLTKLLNDMRA 319
Query: 247 EYELIIKKKHRDLDTWYKEQSAAMSQEAASPA-TVQSRQGDIHELKRTFQALEIDLQTQY 305
+YE + ++ R+ + + +QSA++ + ++ A S + +I ELKRT QALEI+LQ+Q
Sbjct: 320 QYEELAEQNRREAEERFNKQSASLQAQISTDAGAATSAKNEITELKRTLQALEIELQSQL 379
Query: 306 STKSALENMLSETQSRYSCKLQDMQEIISHYEEELTQLRHELERQNNEYQVLLGIKTHLE 365
+ KS+LE L++T++ Y +L ++Q IS EEE+ Q+ E + QN EY+ LL IKT LE
Sbjct: 380 AMKSSLEGTLADTEAGYVAQLSEIQTQISALEEEICQIWGETKCQNAEYKQLLDIKTRLE 439
Query: 366 KEITTYRRLLEGESEGT-------REESKSSM--------------------KVSATPKI 398
EI TYRRLL+GE G+ R +M S T
Sbjct: 440 VEIETYRRLLDGEGGGSSFAEFGGRNSGSVNMGSRDLVSGDSRSGSCSGQGRDSSKTRVT 499
Query: 399 KAITQETINGRLVLCQVNEIQK 420
K I +E ++G++V QV+ I +
Sbjct: 500 KTIVEELVDGKVVSSQVSSISE 521
>gi|114431246 keratin 25D [Homo sapiens]
Length = 464
Score = 286 bits (732), Expect = 2e-77
Identities = 168/444 (37%), Positives = 253/444 (56%), Gaps = 30/444 (6%)
Query: 3 SGHSFSQTPSASFHGAGGGWGRPRSFPRAPTVHGGAGGARISLSFTTRSCPPPGGSWG-- 60
S H ++ + S GG G F + G G+ S + PGGS
Sbjct: 9 SRHVCLRSGAGSVRPLNGGAG----FAGSSACGGSVAGSEFSCALGGGLGSVPGGSHAGG 64
Query: 61 ----------SGRSSPLLGGNGKATMQNLNDRLASYLEKVRALEEANMKLESRILKWHQQ 110
+G LL GN K TMQNLNDRLASYL+ VRALEEAN +LE +I W+++
Sbjct: 65 ALGNAACIGFAGSEGGLLSGNEKVTMQNLNDRLASYLDNVRALEEANAELERKIKGWYEK 124
Query: 111 RDPGSKK----DYSQYEENITHLQEQIVDGKMTNAQIILLIDNARMAVDDFNLKYENEHS 166
PGS + DYS+Y I L+ +I+ TNA +IL IDNAR+A DDF LKYENE +
Sbjct: 125 YGPGSCRGLDHDYSRYHLTIEDLKNKIISSTTTNANVILQIDNARLAADDFRLKYENELT 184
Query: 167 FKKDLEIEVEGLRRTLDNLTIVTTDLEQEVEGMRKELILMKKHHEQEMEKHHVPSDFNVN 226
+++E ++ GLRR LD LT+ TD E + E + +E+ +KK+HE+EM+ + NVN
Sbjct: 185 LHQNVEADINGLRRVLDELTLCRTDQELQYESLSEEMTYLKKNHEEEMKALQCAAGGNVN 244
Query: 227 VKVDTGPREDLIKVLEDMRQEYELIIKKKHRDLDTWYKEQSAAMSQEAASPATVQS-RQG 285
V+++ P DL +L +MR EYE + ++ +D + W+ E+SA++ Q+ + + + +
Sbjct: 245 VEMNAAPGVDLAVLLNNMRAEYEALAEQNRKDAEAWFNEKSASLQQQISHDSGAATFARS 304
Query: 286 DIHELKRTFQALEIDLQTQYSTKSALENMLSETQSRYSCKLQDMQEIISHYEEELTQLRH 345
+ E++RT Q LEI LQ+ +TK +LE L+ET+S Y +L +Q I EE+L Q+R
Sbjct: 305 QLTEMRRTLQTLEIQLQSLMATKHSLECSLTETESNYCTQLAQIQAQIGALEEQLHQVRT 364
Query: 346 ELERQNNEYQVLLGIKTHLEKEITTYRRLLEGESE--------GTREESKSSMKVSATPK 397
E E Q EY+ LL +K HLEKEI TY RL++G+ G+ SS +S T
Sbjct: 365 ETEGQKLEYEHLLDVKVHLEKEIETYCRLIDGDGNSCSKSKGFGSGSPGNSSKDLSKTTL 424
Query: 398 IKAITQE-TINGRLVLCQVNEIQK 420
+K + +E G+++ +++ I++
Sbjct: 425 VKTVVEELDQRGKVLSSRIHSIEE 448
>gi|153945736 keratin 27 [Homo sapiens]
Length = 459
Score = 284 bits (727), Expect = 9e-77
Identities = 171/432 (39%), Positives = 249/432 (57%), Gaps = 40/432 (9%)
Query: 1 MNSGHSFSQTPSASFHGAGGGWGRPRSFPRAPTVHGGAGGARISLSFTTRSCPPPGGSWG 60
+ SG S + S+S G GGG G GG+ +FT
Sbjct: 41 IGSGFSCAFGGSSSAGGYGGGLG---------------GGSASCAAFT------------ 73
Query: 61 SGRSSPLLGGNGKATMQNLNDRLASYLEKVRALEEANMKLESRILKWHQQRDPGSKK--- 117
G LL GN K TMQNLNDRLASYLE VRALEEAN LE +I W+++ PGS +
Sbjct: 74 -GNEHGLLSGNEKVTMQNLNDRLASYLENVRALEEANADLEQKIKGWYEKFGPGSCRGLD 132
Query: 118 -DYSQYEENITHLQEQIVDGKMTNAQIILLIDNARMAVDDFNLKYENEHSFKKDLEIEVE 176
DYS+Y I L+ QI+ +NA ++L DNAR+ DDF LK+ENE + + +E ++
Sbjct: 133 HDYSRYFPIIDELKNQIISATTSNAHVVLQNDNARLTADDFRLKFENELALHQSVEADIN 192
Query: 177 GLRRTLDNLTIVTTDLEQEVEGMRKELILMKKHHEQEMEKHHVPSDFNVNVKVDTGPRED 236
GLRR LD LT+ TDLE ++E + +EL +KK+HE+EM+ + NVNV+++ P D
Sbjct: 193 GLRRVLDELTLCRTDLEIQLETLSEELAYLKKNHEEEMKALQCAAGGNVNVEMNAAPGVD 252
Query: 237 LIKVLEDMRQEYELIIKKKHRDLDTWYKEQSAAMSQEAASPA-TVQSRQGDIHELKRTFQ 295
L +L +MR EYE + ++ RD + W+ E+SA++ Q+ + A S + ++ E+KRT Q
Sbjct: 253 LTVLLNNMRAEYEALAEQNRRDAEAWFNEKSASLQQQISDDAGATTSARNELIEMKRTLQ 312
Query: 296 ALEIDLQTQYSTKSALENMLSETQSRYSCKLQDMQEIISHYEEELTQLRHELERQNNEYQ 355
LEI+LQ+ +TK +LE L+ET+S Y +L +Q I EE+L Q+R E E Q EY+
Sbjct: 313 TLEIELQSLLATKHSLECSLTETESNYCAQLAQIQAQIGALEEQLHQVRTETEGQKLEYE 372
Query: 356 VLLGIKTHLEKEITTYRRLLEGE------SEGTREESKSSMKVSATPKIKAITQE-TING 408
LL IK HLEKEI TY L++GE S+G + S T +K + +E G
Sbjct: 373 QLLDIKVHLEKEIETYCLLIDGEDGSCSKSKGYGGPGNQTKDSSKTTIVKTVVEEIDPRG 432
Query: 409 RLVLCQVNEIQK 420
+++ +V+ +++
Sbjct: 433 KVLSSRVHTVEE 444
>gi|55956899 keratin 9 [Homo sapiens]
Length = 623
Score = 274 bits (701), Expect = 1e-73
Identities = 155/366 (42%), Positives = 228/366 (62%), Gaps = 26/366 (7%)
Query: 17 GAGGGWGRPRSFPRAPTVHGGAGGARISLSFTTRSCPPPGGSWGSGRSSPLLGGNGKATM 76
G GGG+G + GG GG GG G G +L N K+TM
Sbjct: 122 GFGGGYG---------SGFGGFGGF--------------GGGAGGGDGG-ILTANEKSTM 157
Query: 77 QNLNDRLASYLEKVRALEEANMKLESRILKWHQQRDPGS-KKDYSQYEENITHLQEQIVD 135
Q LN RLASYL+KV+ALEEAN LE++I W+ ++ P + +K+YS Y I L++QIVD
Sbjct: 158 QELNSRLASYLDKVQALEEANNDLENKIQDWYDKKGPAAIQKNYSPYYNTIDDLKDQIVD 217
Query: 136 GKMTNAQIILLIDNARMAVDDFNLKYENEHSFKKDLEIEVEGLRRTLDNLTIVTTDLEQE 195
+ N + +L IDN RM +DDF +K+E E + ++ ++ ++ GLR+ LDNLT+ +DLE +
Sbjct: 218 LTVGNNKTLLDIDNTRMTLDDFRIKFEMEQNLRQGVDADINGLRQVLDNLTMEKSDLEMQ 277
Query: 196 VEGMRKELILMKKHHEQEMEKHHVPSDFNVNVKVDTGPREDLIKVLEDMRQEYELIIKKK 255
E +++EL+ +KK+H++EM + + +VNV+++ P +DL K L DMRQEYE +I K
Sbjct: 278 YETLQEELMALKKNHKEEMSQLTGQNSGDVNVEINVAPGKDLTKTLNDMRQEYEQLIAKN 337
Query: 256 HRDLDTWYKEQSAAMSQEAASPA-TVQSRQGDIHELKRTFQALEIDLQTQYSTKSALENM 314
+D++ Y+ Q + E +S VQS ++ +L+ Q LEI+LQ+Q S K+ALE
Sbjct: 338 RKDIENQYETQITQIEHEVSSSGQEVQSSAKEVTQLRHGVQELEIELQSQLSKKAALEKS 397
Query: 315 LSETQSRYSCKLQDMQEIISHYEEELTQLRHELERQNNEYQVLLGIKTHLEKEITTYRRL 374
L +T++RY +LQ +QE IS+ E ++T +R E+E QN EY +LL IK LEKEI TY L
Sbjct: 398 LEDTKNRYCGQLQMIQEQISNLEAQITDVRQEIECQNQEYSLLLSIKMRLEKEIETYHNL 457
Query: 375 LEGESE 380
LEG E
Sbjct: 458 LEGGQE 463
>gi|31559829 keratin 25 [Homo sapiens]
Length = 450
Score = 270 bits (690), Expect = 2e-72
Identities = 157/380 (41%), Positives = 219/380 (57%), Gaps = 21/380 (5%)
Query: 4 GHSFSQTPSASFHGAGGGWGRPRSFPRAPTVHGGAGGARISLSFTTRSCPPPGGSWGSGR 63
G SF S G G G+ S + G GG FT
Sbjct: 27 GTSFGTGNSCGISGIGSGFS---SAFGGSSSGGNTGGGNPCAGFTVNE------------ 71
Query: 64 SSPLLGGNGKATMQNLNDRLASYLEKVRALEEANMKLESRILKWHQQRDPGSKK----DY 119
LL GN K TMQNLNDRLASYL+ V ALEEAN LE +I W+++ PGS + DY
Sbjct: 72 -RGLLSGNEKVTMQNLNDRLASYLDSVHALEEANADLEQKIKGWYEKFGPGSCRGLDHDY 130
Query: 120 SQYEENITHLQEQIVDGKMTNAQIILLIDNARMAVDDFNLKYENEHSFKKDLEIEVEGLR 179
S+Y I L+ QI+ +NA +L IDNAR+ DDF LKYENE + + +E +V GLR
Sbjct: 131 SRYFPIIDDLKNQIIASTTSNANAVLQIDNARLTADDFRLKYENELALHQSVEADVNGLR 190
Query: 180 RTLDNLTIVTTDLEQEVEGMRKELILMKKHHEQEMEKHHVPSDFNVNVKVDTGPREDLIK 239
R LD +T+ TDLE + E + +E+ +KK+H++EM+ + NVNV+++ P DL
Sbjct: 191 RVLDEITLCRTDLEIQYETLSEEMTYLKKNHKEEMQVLQCAAGGNVNVEMNAAPGVDLTV 250
Query: 240 VLEDMRQEYELIIKKKHRDLDTWYKEQSAAMSQEAASP-ATVQSRQGDIHELKRTFQALE 298
+L +MR EYE + ++ RD + W+ E+SA++ Q+ + S + ++ E+KRT Q LE
Sbjct: 251 LLNNMRAEYEALAEQNRRDAEAWFNEKSASLQQQISEDVGATTSARNELTEMKRTLQTLE 310
Query: 299 IDLQTQYSTKSALENMLSETQSRYSCKLQDMQEIISHYEEELTQLRHELERQNNEYQVLL 358
I+LQ+ +TK +LE L+ET+S Y +L +Q I EE+L Q+R E E Q EY+ LL
Sbjct: 311 IELQSLLATKHSLECSLTETESNYCAQLAQIQAQIGALEEQLHQVRTETEGQKLEYEQLL 370
Query: 359 GIKTHLEKEITTYRRLLEGE 378
IK HLEKEI TY L+ G+
Sbjct: 371 DIKLHLEKEIETYCLLIGGD 390
>gi|116488398 keratin 32 [Homo sapiens]
Length = 448
Score = 269 bits (687), Expect = 4e-72
Identities = 145/342 (42%), Positives = 218/342 (63%), Gaps = 6/342 (1%)
Query: 43 ISLSFTTRSCPPPGG-----SWGSGRSSPLLGGNGKATMQNLNDRLASYLEKVRALEEAN 97
+S ++ + SC G GS S GN K TMQ LNDRLASYL +VR LE+ N
Sbjct: 62 LSKTYLSSSCQAASGISGSMGPGSWYSEGAFNGNEKETMQFLNDRLASYLTRVRQLEQEN 121
Query: 98 MKLESRILKWHQQRDPGSKKDYSQYEENITHLQEQIVDGKMTNAQIILLIDNARMAVDDF 157
+LESRI + + DY + I LQ++I+ K NA++++ IDNA++A DDF
Sbjct: 122 AELESRIQEASHSQVLTMTPDYQSHFRTIEELQQKILCTKAENARMVVNIDNAKLAADDF 181
Query: 158 NLKYENEHSFKKDLEIEVEGLRRTLDNLTIVTTDLEQEVEGMRKELILMKKHHEQEMEKH 217
KYE E + ++ +E ++ GLRR LD+LT+ DLE +VE +++EL+ +KK+HE+E+
Sbjct: 182 RAKYEAELAMRQLVEADINGLRRILDDLTLCKADLEAQVESLKEELMCLKKNHEEEVGSL 241
Query: 218 HVPSDFNVNVKVDTGPREDLIKVLEDMRQEYELIIKKKHRDLDTWYKEQSAAMSQE-AAS 276
+N++VD P DL +VLE+MR +YE +++ RD++ W+ Q ++Q+ A S
Sbjct: 242 RCQLGDRLNIEVDAAPPVDLTRVLEEMRCQYEAMVEANRRDVEEWFNMQMEELNQQVATS 301
Query: 277 PATVQSRQGDIHELKRTFQALEIDLQTQYSTKSALENMLSETQSRYSCKLQDMQEIISHY 336
+Q+ Q DI +L+RT LEI+LQ Q+S + +LEN L+E+++RYS +L MQ +I++
Sbjct: 302 SEQLQNYQSDIIDLRRTVNTLEIELQAQHSLRDSLENTLTESEARYSSQLAQMQCMITNV 361
Query: 337 EEELTQLRHELERQNNEYQVLLGIKTHLEKEITTYRRLLEGE 378
E +L ++R +LERQN EYQVLL ++ LE EI TYR LLE E
Sbjct: 362 EAQLAEIRADLERQNQEYQVLLDVRARLEGEINTYRSLLENE 403
>gi|31559815 keratin 26 [Homo sapiens]
Length = 468
Score = 269 bits (687), Expect = 4e-72
Identities = 172/420 (40%), Positives = 237/420 (56%), Gaps = 29/420 (6%)
Query: 8 SQTPSASFHGAGGGWGRPRSFPRAPTVHGGAGGARISLSFTTRSCPP------PGGSWGS 61
S+T S G G G+ A V G+G AR S S T GG GS
Sbjct: 14 SRTGSGRLSGGGTGFV-------AGNVCVGSG-ARSSFSCTLEGISSGGSFCNSGGGLGS 65
Query: 62 GRSSPLLG-------GNGKATMQNLNDRLASYLEKVRALEEANMKLESRILKWHQQRDPG 114
G + LG GN K TMQNLNDRLASYL+ V ALEEAN LE +I +++ +PG
Sbjct: 66 GACAGFLGNEHSLLSGNEKVTMQNLNDRLASYLDHVHALEEANADLEQKIKGRYEKCEPG 125
Query: 115 SKK----DYSQYEENITHLQEQIVDGKMTNAQIILLIDNARMAVDDFNLKYENEHSFKKD 170
S + DYS+Y I L+ QI + NA I+L DNAR+ DDF LKYENE +
Sbjct: 126 SSREHDHDYSRYFSVIEDLKRQITSATICNASIVLQNDNARLTADDFRLKYENELALHHS 185
Query: 171 LEIEVEGLRRTLDNLTIVTTDLEQEVEGMRKELILMKKHHEQEMEKHHVPSDFNVNVKVD 230
+E + GLRR LD LT+ TTDLE + E + +EL +KK HE+EME + NVNV+++
Sbjct: 186 VEADTSGLRRVLDELTLCTTDLEIQCETLSEELTYLKKSHEEEMEVLQYTAGGNVNVEMN 245
Query: 231 TGPREDLIKVLEDMRQEYELIIKKKHRDLDTWYKEQSAAMSQEAAS-PATVQSRQGDIHE 289
P DL +L +MR EYE + ++ +D + W+ E+SA + Q+ + + + ++ E
Sbjct: 246 ATPGVDLTVLLNNMRAEYEDLAEQNRKDAEAWFNERSATLQQQISDHEGAATAARNELTE 305
Query: 290 LKRTFQALEIDLQTQYSTKSALENMLSETQSRYSCKLQDMQEIISHYEEELTQLRHELER 349
LKR Q LEI+LQ+ + K + E L+ET+ Y +LQ +Q+ I EE+L Q+R E E
Sbjct: 306 LKRNLQTLEIELQSLMAVKHSYECSLAETEGNYCNQLQQIQDQIGVMEEQLQQIRTETEG 365
Query: 350 QNNEYQVLLGIKTHLEKEITTYRRLLEGE---SEGTREESKSSMKVSATPKIKAITQETI 406
Q EY+ LL +K LEKEI Y LL+GE S+ T +SK V++ + K T+ETI
Sbjct: 366 QKLEYEQLLDVKIFLEKEIDIYCNLLDGEERKSKSTCYKSKGYRPVNSGNQAKDSTEETI 425
>gi|14917117 keratin 33A [Homo sapiens]
Length = 404
Score = 268 bits (685), Expect = 7e-72
Identities = 137/310 (44%), Positives = 210/310 (67%), Gaps = 1/310 (0%)
Query: 70 GNGKATMQNLNDRLASYLEKVRALEEANMKLESRILKWHQQRDPGSKKDYSQYEENITHL 129
G+ K TMQ LNDRLASYLEKVR LE N +LE+ I + QQ++P Y Y + I L
Sbjct: 54 GSEKETMQFLNDRLASYLEKVRQLERDNAELENLIRERSQQQEPLVCASYQSYFKTIEEL 113
Query: 130 QEQIVDGKMTNAQIILLIDNARMAVDDFNLKYENEHSFKKDLEIEVEGLRRTLDNLTIVT 189
Q++I+ K NA++++ IDNA++A DDF KYE E S ++ +E ++ GLRR LD LT+
Sbjct: 114 QQKILCSKSENARLVVQIDNAKLASDDFRTKYETELSLRQLVESDINGLRRILDELTLCR 173
Query: 190 TDLEQEVEGMRKELILMKKHHEQEMEKHHVPSDFNVNVKVDTGPREDLIKVLEDMRQEYE 249
+DLE +VE +++EL+ +K++HEQE+ +NV+VD P DL +VL + R +YE
Sbjct: 174 SDLEAQVESLKEELLCLKQNHEQEVNTLRCQLGDRLNVEVDAAPTVDLNQVLNETRSQYE 233
Query: 250 LIIKKKHRDLDTWYKEQSAAMSQEAASPA-TVQSRQGDIHELKRTFQALEIDLQTQYSTK 308
+++ R+++ W+ Q+ ++++ S + +QS Q +I EL+RT ALEI+LQ Q++ +
Sbjct: 234 ALVETNRREVEQWFATQTEELNKQVVSSSEQLQSYQAEIIELRRTVNALEIELQAQHNLR 293
Query: 309 SALENMLSETQSRYSCKLQDMQEIISHYEEELTQLRHELERQNNEYQVLLGIKTHLEKEI 368
+LEN L+E+++RYS +L +Q +I++ E +L ++R +LERQN EYQVLL ++ LE EI
Sbjct: 294 DSLENTLTESEARYSSQLSQVQRLITNVESQLAEIRSDLERQNQEYQVLLDVRARLECEI 353
Query: 369 TTYRRLLEGE 378
TYR LLE E
Sbjct: 354 NTYRSLLESE 363
>gi|14917115 keratin 31 [Homo sapiens]
Length = 416
Score = 267 bits (682), Expect = 2e-71
Identities = 136/310 (43%), Positives = 209/310 (67%), Gaps = 1/310 (0%)
Query: 70 GNGKATMQNLNDRLASYLEKVRALEEANMKLESRILKWHQQRDPGSKKDYSQYEENITHL 129
G+ K TMQ LNDRLASYLEKVR LE N +LE+ I + QQ++P Y Y + I L
Sbjct: 54 GSEKETMQFLNDRLASYLEKVRQLERDNAELENLIRERSQQQEPLLCPSYQSYFKTIEEL 113
Query: 130 QEQIVDGKMTNAQIILLIDNARMAVDDFNLKYENEHSFKKDLEIEVEGLRRTLDNLTIVT 189
Q++I+ K NA++++ IDNA++A DDF KY+ E S ++ +E ++ GLRR LD LT+
Sbjct: 114 QQKILCTKSENARLVVQIDNAKLAADDFRTKYQTELSLRQLVESDINGLRRILDELTLCK 173
Query: 190 TDLEQEVEGMRKELILMKKHHEQEMEKHHVPSDFNVNVKVDTGPREDLIKVLEDMRQEYE 249
+DLE +VE +++EL+ +K +HEQE+ +NV+VD P DL +VL + R +YE
Sbjct: 174 SDLEAQVESLKEELLCLKSNHEQEVNTLRCQLGDRLNVEVDAAPTVDLNRVLNETRSQYE 233
Query: 250 LIIKKKHRDLDTWYKEQSAAMSQEAASPA-TVQSRQGDIHELKRTFQALEIDLQTQYSTK 308
+++ R+++ W+ Q+ ++++ S + +QS Q +I EL+RT ALEI+LQ Q++ +
Sbjct: 234 ALVETNRREVEQWFTTQTEELNKQVVSSSEQLQSYQAEIIELRRTVNALEIELQAQHNLR 293
Query: 309 SALENMLSETQSRYSCKLQDMQEIISHYEEELTQLRHELERQNNEYQVLLGIKTHLEKEI 368
+LEN L+E+++RYS +L +Q +I++ E +L ++R +LERQN EYQVLL ++ LE EI
Sbjct: 294 DSLENTLTESEARYSSQLSQVQSLITNVESQLAEIRSDLERQNQEYQVLLDVRARLECEI 353
Query: 369 TTYRRLLEGE 378
TYR LLE E
Sbjct: 354 NTYRSLLESE 363
>gi|10337581 type I hair keratin 3B [Homo sapiens]
Length = 404
Score = 264 bits (675), Expect = 1e-70
Identities = 134/310 (43%), Positives = 209/310 (67%), Gaps = 1/310 (0%)
Query: 70 GNGKATMQNLNDRLASYLEKVRALEEANMKLESRILKWHQQRDPGSKKDYSQYEENITHL 129
G+ K TMQ LNDRLASYLEKVR LE N +LE+ I + QQ++P Y Y + I L
Sbjct: 54 GSEKETMQFLNDRLASYLEKVRQLERDNAELENLIRERSQQQEPLLCPSYQSYFKTIEEL 113
Query: 130 QEQIVDGKMTNAQIILLIDNARMAVDDFNLKYENEHSFKKDLEIEVEGLRRTLDNLTIVT 189
Q++I+ K NA++++ IDNA++A DDF KY+ E S ++ +E ++ LRR LD LT+
Sbjct: 114 QQKILCSKSENARLVVQIDNAKLAADDFRTKYQTEQSLRQLVESDINSLRRILDELTLCR 173
Query: 190 TDLEQEVEGMRKELILMKKHHEQEMEKHHVPSDFNVNVKVDTGPREDLIKVLEDMRQEYE 249
+DLE ++E +++EL+ +K++HEQE+ +NV+VD P DL +VL + R +YE
Sbjct: 174 SDLEAQMESLKEELLSLKQNHEQEVNTLRCQLGDRLNVEVDAAPAVDLNQVLNETRNQYE 233
Query: 250 LIIKKKHRDLDTWYKEQSAAMSQEAASPA-TVQSRQGDIHELKRTFQALEIDLQTQYSTK 308
+++ R+++ W+ Q+ ++++ S + +QS Q +I EL+RT ALEI+LQ Q++ +
Sbjct: 234 ALVETNRREVEQWFATQTEELNKQVVSSSEQLQSYQAEIIELRRTVNALEIELQAQHNLR 293
Query: 309 SALENMLSETQSRYSCKLQDMQEIISHYEEELTQLRHELERQNNEYQVLLGIKTHLEKEI 368
+LEN L+E+++RYS +L +Q +I++ E +L ++R +LERQN EYQVLL ++ LE EI
Sbjct: 294 YSLENTLTESEARYSSQLSQVQSLITNVESQLAEIRSDLERQNQEYQVLLDVRARLECEI 353
Query: 369 TTYRRLLEGE 378
TYR LLE E
Sbjct: 354 NTYRSLLESE 363
>gi|14917119 keratin 34 [Homo sapiens]
Length = 436
Score = 263 bits (672), Expect = 2e-70
Identities = 136/310 (43%), Positives = 207/310 (66%), Gaps = 1/310 (0%)
Query: 70 GNGKATMQNLNDRLASYLEKVRALEEANMKLESRILKWHQQRDPGSKKDYSQYEENITHL 129
G+ K TMQ LNDRLASYLEKVR LE N +LE I + QQ++P Y Y + I L
Sbjct: 96 GSEKETMQFLNDRLASYLEKVRQLERDNAELEKLIQERSQQQEPLLCPSYQSYFKTIEEL 155
Query: 130 QEQIVDGKMTNAQIILLIDNARMAVDDFNLKYENEHSFKKDLEIEVEGLRRTLDNLTIVT 189
Q++I+ K NA++++ IDNA++A DDF KY+ E S + +E ++ +RR LD LT+
Sbjct: 156 QQKILCAKAENARLVVNIDNAKLASDDFRSKYQTEQSLRLLVESDINSIRRILDELTLCK 215
Query: 190 TDLEQEVEGMRKELILMKKHHEQEMEKHHVPSDFNVNVKVDTGPREDLIKVLEDMRQEYE 249
+DLE +VE +R+ELI +KK+HE+E+ +NV+VDT P DL +VL + R +YE
Sbjct: 216 SDLESQVESLREELICLKKNHEEEVNTLRSQLGDRLNVEVDTAPTVDLNQVLNETRSQYE 275
Query: 250 LIIKKKHRDLDTWYKEQSAAMSQEAASPA-TVQSRQGDIHELKRTFQALEIDLQTQYSTK 308
+++ R+++ W+ Q+ ++++ S + +QS Q +I EL+RT ALEI+LQ Q++ +
Sbjct: 276 ALVEINRREVEQWFATQTEELNKQVVSSSEQLQSCQAEIIELRRTVNALEIELQAQHNLR 335
Query: 309 SALENMLSETQSRYSCKLQDMQEIISHYEEELTQLRHELERQNNEYQVLLGIKTHLEKEI 368
+LEN L+E+++ YS +L +Q +I++ E +L ++R +LERQN EYQVLL ++ LE EI
Sbjct: 336 DSLENTLTESEAHYSSQLSQVQSLITNVESQLAEIRCDLERQNQEYQVLLDVRARLECEI 395
Query: 369 TTYRRLLEGE 378
TYR LLE E
Sbjct: 396 NTYRSLLESE 405
>gi|40354195 keratin 18 [Homo sapiens]
Length = 430
Score = 255 bits (651), Expect = 6e-68
Identities = 152/401 (37%), Positives = 241/401 (60%), Gaps = 23/401 (5%)
Query: 26 RSFPRAPTVHGGAGGA--RISLSFTTRSCPPPGGSWGSGRSSPLLGG--------NGKAT 75
R A +V+ GAGG+ RIS+S RS GG G ++ + GG N K T
Sbjct: 27 RPVSSAASVYAGAGGSGSRISVS---RSTSFRGGMGSGGLATGIAGGLAGMGGIQNEKET 83
Query: 76 MQNLNDRLASYLEKVRALEEANMKLESRILKWHQQRDPGSKKDYSQYEENITHLQEQIVD 135
MQ+LNDRLASYL++VR+LE N +LES+I + +++ P +D+S Y + I L+ QI
Sbjct: 84 MQSLNDRLASYLDRVRSLETENRRLESKIREHLEKKGP-QVRDWSHYFKIIEDLRAQIFA 142
Query: 136 GKMTNAQIILLIDNARMAVDDFNLKYENEHSFKKDLEIEVEGLRRTLDNLTIVTTDLEQE 195
+ NA+I+L IDNAR+A DDF +KYE E + ++ +E ++ GLR+ +D+ I LE E
Sbjct: 143 NTVDNARIVLQIDNARLAADDFRVKYETELAMRQSVENDIHGLRKVIDDTNITRLQLETE 202
Query: 196 VEGMRKELILMKKHHEQEMEKHHVP-SDFNVNVKVDTGPREDLIKVLEDMRQEYELIIKK 254
+E +++EL+ MKK+HE+E++ + + V+VD +DL K++ D+R +Y+ + +K
Sbjct: 203 IEALKEELLFMKKNHEEEVKGLQAQIASSGLTVEVDAPKSQDLAKIMADIRAQYDELARK 262
Query: 255 KHRDLDTWYKEQ-SAAMSQEAASPATVQSRQGDIHELKRTFQALEIDLQTQYSTKSALEN 313
+LD ++ +Q + + A V + + + EL+RT Q+LEIDL + + K++LEN
Sbjct: 263 NREELDKYWSQQIEESTTVVTTQSAEVGAAETTLTELRRTVQSLEIDLDSMRNLKASLEN 322
Query: 314 MLSETQSRYSCKLQDMQEIISHYEEELTQLRHELERQNNEYQVLLGIKTHLEKEITTYRR 373
L E ++RY+ +++ + I+ H E EL Q R E +RQ EY+ LL IK LE EI TYRR
Sbjct: 323 SLREVEARYALQMEQLNGILLHLESELAQTRAEGQRQAQEYEALLNIKVKLEAEIATYRR 382
Query: 374 LLEGESE---GTREESKSSMKVSATPKIKAITQETINGRLV 411
LLE + G +S +SM+ K T+ ++G++V
Sbjct: 383 LLEDGEDFNLGDALDSSNSMQTIQ----KTTTRRIVDGKVV 419
>gi|4557888 keratin 18 [Homo sapiens]
Length = 430
Score = 255 bits (651), Expect = 6e-68
Identities = 152/401 (37%), Positives = 241/401 (60%), Gaps = 23/401 (5%)
Query: 26 RSFPRAPTVHGGAGGA--RISLSFTTRSCPPPGGSWGSGRSSPLLGG--------NGKAT 75
R A +V+ GAGG+ RIS+S RS GG G ++ + GG N K T
Sbjct: 27 RPVSSAASVYAGAGGSGSRISVS---RSTSFRGGMGSGGLATGIAGGLAGMGGIQNEKET 83
Query: 76 MQNLNDRLASYLEKVRALEEANMKLESRILKWHQQRDPGSKKDYSQYEENITHLQEQIVD 135
MQ+LNDRLASYL++VR+LE N +LES+I + +++ P +D+S Y + I L+ QI
Sbjct: 84 MQSLNDRLASYLDRVRSLETENRRLESKIREHLEKKGP-QVRDWSHYFKIIEDLRAQIFA 142
Query: 136 GKMTNAQIILLIDNARMAVDDFNLKYENEHSFKKDLEIEVEGLRRTLDNLTIVTTDLEQE 195
+ NA+I+L IDNAR+A DDF +KYE E + ++ +E ++ GLR+ +D+ I LE E
Sbjct: 143 NTVDNARIVLQIDNARLAADDFRVKYETELAMRQSVENDIHGLRKVIDDTNITRLQLETE 202
Query: 196 VEGMRKELILMKKHHEQEMEKHHVP-SDFNVNVKVDTGPREDLIKVLEDMRQEYELIIKK 254
+E +++EL+ MKK+HE+E++ + + V+VD +DL K++ D+R +Y+ + +K
Sbjct: 203 IEALKEELLFMKKNHEEEVKGLQAQIASSGLTVEVDAPKSQDLAKIMADIRAQYDELARK 262
Query: 255 KHRDLDTWYKEQ-SAAMSQEAASPATVQSRQGDIHELKRTFQALEIDLQTQYSTKSALEN 313
+LD ++ +Q + + A V + + + EL+RT Q+LEIDL + + K++LEN
Sbjct: 263 NREELDKYWSQQIEESTTVVTTQSAEVGAAETTLTELRRTVQSLEIDLDSMRNLKASLEN 322
Query: 314 MLSETQSRYSCKLQDMQEIISHYEEELTQLRHELERQNNEYQVLLGIKTHLEKEITTYRR 373
L E ++RY+ +++ + I+ H E EL Q R E +RQ EY+ LL IK LE EI TYRR
Sbjct: 323 SLREVEARYALQMEQLNGILLHLESELAQTRAEGQRQAQEYEALLNIKVKLEAEIATYRR 382
Query: 374 LLEGESE---GTREESKSSMKVSATPKIKAITQETINGRLV 411
LLE + G +S +SM+ K T+ ++G++V
Sbjct: 383 LLEDGEDFNLGDALDSSNSMQTIQ----KTTTRRIVDGKVV 419
>gi|15431318 keratin 38 [Homo sapiens]
Length = 456
Score = 246 bits (628), Expect = 3e-65
Identities = 134/340 (39%), Positives = 210/340 (61%), Gaps = 16/340 (4%)
Query: 51 SCPPPG-----------GSWGSGRSSPLLGGNGKATMQNLNDRLASYLEKVRALEEANMK 99
+CP PG G++G L G+ K TMQ LNDRLA+YLEKVR LE+ N +
Sbjct: 76 ACPLPGTCHIPGNIGICGAYGENT----LNGHEKETMQFLNDRLANYLEKVRQLEQENAE 131
Query: 100 LESRILKWHQQRDPGSKKDYSQYEENITHLQEQIVDGKMTNAQIILLIDNARMAVDDFNL 159
LE+ +L+ + + DY Y I LQ++I+ K NA++I+ IDNA++A DDF +
Sbjct: 132 LEATLLERSKCHESTVCPDYQSYFHTIEELQQKILCSKAENARLIVQIDNAKLAADDFRI 191
Query: 160 KYENEHSFKKDLEIEVEGLRRTLDNLTIVTTDLEQEVEGMRKELILMKKHHEQEMEKHHV 219
K E+E S ++ +E + G ++ LD+ T+ DLE + E +++E + +K +HEQE++
Sbjct: 192 KLESERSLRQLVEADKCGTQKLLDDATLAKADLEAQQESLKEEQLSLKSNHEQEVKILRS 251
Query: 220 PSDFNVNVKVDTGPREDLIKVLEDMRQEYELIIKKKHRDLDTWYKEQSAAMS-QEAASPA 278
+ +++D P DL +VL +MR +YE +++ +D++ W++ QS +S Q+ +
Sbjct: 252 QLGEKLRIELDIEPTIDLNRVLGEMRAQYEAMLETNRQDVEQWFQAQSEGISLQDMSCSE 311
Query: 279 TVQSRQGDIHELKRTFQALEIDLQTQYSTKSALENMLSETQSRYSCKLQDMQEIISHYEE 338
+Q Q +I EL+ T ALE++ Q Q++ K L+N L E + R+ +L MQ +IS+ EE
Sbjct: 312 ELQCCQSEILELRCTVNALEVERQAQHTLKDCLQNSLCEAEDRFGTELAQMQSLISNVEE 371
Query: 339 ELTQLRHELERQNNEYQVLLGIKTHLEKEITTYRRLLEGE 378
+L+++R +LERQN EYQVLL +KT LE EI TYR LLE E
Sbjct: 372 QLSEIRADLERQNQEYQVLLDVKTRLENEIATYRNLLESE 411
>gi|55770882 keratin 37 [Homo sapiens]
Length = 449
Score = 246 bits (628), Expect = 3e-65
Identities = 135/340 (39%), Positives = 208/340 (61%), Gaps = 16/340 (4%)
Query: 51 SCPPPG-----------GSWGSGRSSPLLGGNGKATMQNLNDRLASYLEKVRALEEANMK 99
+CP PG G++G L G+ K TM+ LNDRLA+YLEKVR LE+ N +
Sbjct: 76 ACPLPGTCHIPGNIGICGAYGKNT----LNGHEKETMKFLNDRLANYLEKVRQLEQENAE 131
Query: 100 LESRILKWHQQRDPGSKKDYSQYEENITHLQEQIVDGKMTNAQIILLIDNARMAVDDFNL 159
LE+ +L+ + + DY Y I LQ++I+ K NA++I+ IDNA++A DDF +
Sbjct: 132 LETTLLERSKCHESTVCPDYQSYFRTIEELQQKILCSKAENARLIVQIDNAKLAADDFRI 191
Query: 160 KYENEHSFKKDLEIEVEGLRRTLDNLTIVTTDLEQEVEGMRKELILMKKHHEQEMEKHHV 219
K E+E S + +E + G ++ LD+ T+ DLE + E +++E + +K +HEQE++
Sbjct: 192 KLESERSLHQLVEADKCGTQKLLDDATLAKADLEAQQESLKEEQLSLKSNHEQEVKILRS 251
Query: 220 PSDFNVNVKVDTGPREDLIKVLEDMRQEYELIIKKKHRDLDTWYKEQSAAMSQEAAS-PA 278
+++D P DL +VL +MR +YE +++ H+D++ W++ QS +S +A S
Sbjct: 252 QLGEKFRIELDIEPTIDLNRVLGEMRAQYEAMVETNHQDVEQWFQAQSEGISLQAMSCSE 311
Query: 279 TVQSRQGDIHELKRTFQALEIDLQTQYSTKSALENMLSETQSRYSCKLQDMQEIISHYEE 338
+Q Q +I EL+ T ALE++ Q Q++ K L+N L E + RY +L MQ +IS+ EE
Sbjct: 312 ELQCCQSEILELRCTVNALEVERQAQHTLKDCLQNSLCEAEDRYGTELAQMQSLISNLEE 371
Query: 339 ELTQLRHELERQNNEYQVLLGIKTHLEKEITTYRRLLEGE 378
+L+++R +LERQN EYQVLL +K LE EI TYR LLE E
Sbjct: 372 QLSEIRADLERQNQEYQVLLDVKARLENEIATYRNLLESE 411
>gi|125490370 type I hair keratin KA36 [Homo sapiens]
Length = 431
Score = 240 bits (613), Expect = 2e-63
Identities = 132/309 (42%), Positives = 199/309 (64%), Gaps = 1/309 (0%)
Query: 71 NGKATMQNLNDRLASYLEKVRALEEANMKLESRILKWHQQRDPGSKKDYSQYEENITHLQ 130
N K TMQ LNDRLASYLEKVR+LEE N +LESRI + +Q P DY +Y I LQ
Sbjct: 88 NEKETMQFLNDRLASYLEKVRSLEETNAELESRIQEQCEQDIPMVCPDYQRYFNTIEDLQ 147
Query: 131 EQIVDGKMTNAQIILLIDNARMAVDDFNLKYENEHSFKKDLEIEVEGLRRTLDNLTIVTT 190
++I+ K N+++ + +DN ++A DDF KYE+E S ++ LE ++ L L+ LT+ +
Sbjct: 148 QKILCTKAENSRLAVQLDNCKLATDDFKSKYESELSLRQLLEADISSLHGILEELTLCKS 207
Query: 191 DLEQEVEGMRKELILMKKHHEQEMEKHHVPSDFNVNVKVDTGPREDLIKVLEDMRQEYEL 250
DLE VE ++++L+ +KK+HE+E+ ++V++DT P DL +VL++MR + E
Sbjct: 208 DLEAHVESLKEDLLCLKKNHEEEVNLLREQLGDRLSVELDTAPTLDLNRVLDEMRCQCET 267
Query: 251 IIKKKHRDLDTWYKEQSAAMSQEAASPA-TVQSRQGDIHELKRTFQALEIDLQTQYSTKS 309
++ R+ + W Q+ ++Q+ S A +Q Q +I ELKRT ALEI+LQ Q S
Sbjct: 268 VLANNRREAEEWLAVQTEELNQQQLSSAEQLQGCQMEILELKRTASALEIELQAQQSLTE 327
Query: 310 ALENMLSETQSRYSCKLQDMQEIISHYEEELTQLRHELERQNNEYQVLLGIKTHLEKEIT 369
+LE ++ET+++YS +L +Q +I + E +L ++R +LERQN EYQVLL +K LE EI
Sbjct: 328 SLECTVAETEAQYSSQLAQIQCLIDNLENQLAEIRCDLERQNQEYQVLLDVKARLEGEIN 387
Query: 370 TYRRLLEGE 378
TY LL+ E
Sbjct: 388 TYWGLLDSE 396
>gi|148277620 type I hair keratin KA35 [Homo sapiens]
Length = 491
Score = 225 bits (573), Expect = 7e-59
Identities = 122/330 (36%), Positives = 201/330 (60%), Gaps = 2/330 (0%)
Query: 68 LGGNGKATMQNLNDRLASYLEKVRALEEANMKLESRILKWHQQRDPGSKKDYSQYEENIT 127
+ N K TMQ LN+RLA+YL+KVR LE N +LES+I + + P DY Y I
Sbjct: 92 INSNEKETMQILNERLANYLQKVRMLERENAELESKIQEESNKELPVLCPDYLSYYTTIE 151
Query: 128 HLQEQIVDGKMTNAQIILLIDNARMAVDDFNLKYENEHSFKKDLEIEVEGLRRTLDNLTI 187
LQ++I+ K N++++ IDN ++ DD KYE E S ++ +E + GL++ L+ LT+
Sbjct: 152 ELQQKILCTKAENSRLVSQIDNTKLTADDLRAKYEAEVSLRQLVESDANGLKQILNVLTL 211
Query: 188 VTTDLEQEVEGMRKELILMKKHHEQEMEKHHVPSDFNVNVKVDTGPREDLIKVLEDMRQE 247
DLE +V+ +++EL+ +K +H++E+ ++++V P DL +VL++MR +
Sbjct: 212 GKADLEAQVQSLKEELLCLKNNHKEEINSLQCQLGERLDIEVTAAPSADLNQVLQEMRCQ 271
Query: 248 YELIIKKKHRDLDTWYKEQSAAMSQE-AASPATVQSRQGDIHELKRTFQALEIDLQTQYS 306
YE I++ +D++ W+ Q ++Q+ S Q Q +I EL+R+ LE++LQ Q+
Sbjct: 272 YEPIMETNRKDVEQWFNTQIEELNQQVVTSSQQQQCCQKEIIELRRSVNTLEVELQAQHR 331
Query: 307 TKSALENMLSETQSRYSCKLQDMQEIISHYEEELTQLRHELERQNNEYQVLLGIKTHLEK 366
+ + E +L+ET++RY+ L +Q +I + E +L ++R LERQN EY++LL +K+ LE
Sbjct: 332 MRDSQECILTETEARYTALLTQIQSLIDNLEAQLAEIRCALERQNQEYEILLDVKSRLEC 391
Query: 367 EITTYRRLLEGESEGTREESKSSMKVSATP 396
EITTYR LLE S+G R + K +P
Sbjct: 392 EITTYRSLLE-SSDGKRPCYPRATKCEPSP 420
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.129 0.361
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,424,028
Number of Sequences: 37866
Number of extensions: 812796
Number of successful extensions: 5601
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 198
Number of HSP's successfully gapped in prelim test: 475
Number of HSP's that attempted gapping in prelim test: 3736
Number of HSP's gapped (non-prelim): 1644
length of query: 422
length of database: 18,247,518
effective HSP length: 105
effective length of query: 317
effective length of database: 14,271,588
effective search space: 4524093396
effective search space used: 4524093396
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.