Search of human proteins with 27886653

Search of human proteins with 27886653

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|27886653 potassium voltage-gated channel, subfamily H,
member 7 isoform 1 [Homo sapiens]
         (1196 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|27886653 potassium voltage-gated channel, subfamily H, member...  2404   0.0  
gi|27886665 potassium voltage-gated channel, subfamily H, member...  1434   0.0  
gi|4557729 voltage-gated potassium channel, subfamily H, member ...  1234   0.0  
gi|26051271 voltage-gated potassium channel, subfamily H, member...  1075   0.0  
gi|13540549 potassium voltage-gated channel, subfamily H, member...   918   0.0  
gi|26051273 voltage-gated potassium channel, subfamily H, member...   903   0.0  
gi|27886651 potassium voltage-gated channel, subfamily H, member...   786   0.0  
gi|27886667 potassium voltage-gated channel, subfamily H, member...   500   e-141
gi|4504831 potassium voltage-gated channel, subfamily H, member ...   472   e-132
gi|22024390 potassium voltage-gated channel, subfamily H, member...   470   e-132
gi|27886648 potassium voltage-gated channel, subfamily H, member...   470   e-132
gi|27437001 potassium voltage-gated channel, subfamily H, member...   462   e-130
gi|6912446 potassium voltage-gated channel, subfamily H, member ...   454   e-127
gi|38569493 potassium voltage-gated channel, subfamily H (eag-re...   422   e-118
gi|27886646 potassium voltage-gated channel, subfamily H, member...   408   e-113
gi|4885407 hyperpolarization activated cyclic nucleotide-gated p...   178   3e-44
gi|156071470 hyperpolarization activated cyclic nucleotide-gated...   173   8e-43
gi|116325989 hyperpolarization activated cyclic nucleotide-gated...   171   3e-42
gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2 [...   163   8e-40
gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Ho...   163   8e-40
gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1 [...   162   2e-39
gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [H...   162   2e-39
gi|38327037 hyperpolarization activated cyclic nucleotide-gated ...   157   7e-38
gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]    154   6e-37
gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]    144   4e-34
gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]    102   2e-21
gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [H...    96   2e-19
gi|205361107 potassium channel, subfamily K, member 17 isoform 2...    43   0.002
gi|17025230 potassium channel, subfamily K, member 17 isoform 1 ...    43   0.002
gi|4758630 potassium voltage-gated channel KQT-like protein 3 [H...    40   0.010

>gi|27886653 potassium voltage-gated channel, subfamily H, member 7
            isoform 1 [Homo sapiens]
          Length = 1196

 Score = 2404 bits (6229), Expect = 0.0
 Identities = 1196/1196 (100%), Positives = 1196/1196 (100%)

Query: 1    MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVM 60
            MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVM
Sbjct: 1    MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVM 60

Query: 61   QKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEG 120
            QKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEG
Sbjct: 61   QKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEG 120

Query: 121  VAMMFIINFEYVTDNENAATPERVNPILPIKTVNRKFFGFKFPGLRVLTYRKQSLPQEDP 180
            VAMMFIINFEYVTDNENAATPERVNPILPIKTVNRKFFGFKFPGLRVLTYRKQSLPQEDP
Sbjct: 121  VAMMFIINFEYVTDNENAATPERVNPILPIKTVNRKFFGFKFPGLRVLTYRKQSLPQEDP 180

Query: 181  DVVVIDSSKHSDDSVAMKHFKSPTKESCSPSEADDTKALIQPSKCSPLVNISGPLDHSSP 240
            DVVVIDSSKHSDDSVAMKHFKSPTKESCSPSEADDTKALIQPSKCSPLVNISGPLDHSSP
Sbjct: 181  DVVVIDSSKHSDDSVAMKHFKSPTKESCSPSEADDTKALIQPSKCSPLVNISGPLDHSSP 240

Query: 241  KRQWDRLYPDMLQSSSQLSHSRSRESLCSIRRASSVHDIEGFGVHPKNIFRDRHASEDNG 300
            KRQWDRLYPDMLQSSSQLSHSRSRESLCSIRRASSVHDIEGFGVHPKNIFRDRHASEDNG
Sbjct: 241  KRQWDRLYPDMLQSSSQLSHSRSRESLCSIRRASSVHDIEGFGVHPKNIFRDRHASEDNG 300

Query: 301  RNVKGPFNHIKSSLLGSTSDSNLNKYSTINKIPQLTLNFSEVKTEKKNSSPPSSDKTIIA 360
            RNVKGPFNHIKSSLLGSTSDSNLNKYSTINKIPQLTLNFSEVKTEKKNSSPPSSDKTIIA
Sbjct: 301  RNVKGPFNHIKSSLLGSTSDSNLNKYSTINKIPQLTLNFSEVKTEKKNSSPPSSDKTIIA 360

Query: 361  PKVKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIY 420
            PKVKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIY
Sbjct: 361  PKVKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIY 420

Query: 421  TAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEE 480
            TAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEE
Sbjct: 421  TAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEE 480

Query: 481  VVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARK 540
            VVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARK
Sbjct: 481  VVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARK 540

Query: 541  LDRYSEYGAAVLMLLMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYN 600
            LDRYSEYGAAVLMLLMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYN
Sbjct: 541  LDRYSEYGAAVLMLLMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYN 600

Query: 601  DSDSSSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFG 660
            DSDSSSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFG
Sbjct: 601  DSDSSSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFG 660

Query: 661  NVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVL 720
            NVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVL
Sbjct: 661  NVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVL 720

Query: 721  KGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLT 780
            KGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLT
Sbjct: 721  KGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLT 780

Query: 781  ALYFLSRGSIEILKDDIVVAILGKNDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQRED 840
            ALYFLSRGSIEILKDDIVVAILGKNDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQRED
Sbjct: 781  ALYFLSRGSIEILKDDIVVAILGKNDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQRED 840

Query: 841  LLEVLDMYPEFSDHFLTNLELTFNLRHESAKADLLRSQSMNDSEGDNCKLRRRKLSFESE 900
            LLEVLDMYPEFSDHFLTNLELTFNLRHESAKADLLRSQSMNDSEGDNCKLRRRKLSFESE
Sbjct: 841  LLEVLDMYPEFSDHFLTNLELTFNLRHESAKADLLRSQSMNDSEGDNCKLRRRKLSFESE 900

Query: 901  GEKENSTNDPEDSADTIRHYQSSKRHFEEKKSRSSSFISSIDDEQKPLFSGIVDSSPGIG 960
            GEKENSTNDPEDSADTIRHYQSSKRHFEEKKSRSSSFISSIDDEQKPLFSGIVDSSPGIG
Sbjct: 901  GEKENSTNDPEDSADTIRHYQSSKRHFEEKKSRSSSFISSIDDEQKPLFSGIVDSSPGIG 960

Query: 961  KASGLDFEETVPTSGRMHIDKRSHSCKDITDMRSWERENAHPQPEDSSPSALQRAAWGIS 1020
            KASGLDFEETVPTSGRMHIDKRSHSCKDITDMRSWERENAHPQPEDSSPSALQRAAWGIS
Sbjct: 961  KASGLDFEETVPTSGRMHIDKRSHSCKDITDMRSWERENAHPQPEDSSPSALQRAAWGIS 1020

Query: 1021 ETESDLTYGEVEQRLDLLQEQLNRLESQMTTDIQTILQLLQKQTTVVPPAYSMVTAGSEY 1080
            ETESDLTYGEVEQRLDLLQEQLNRLESQMTTDIQTILQLLQKQTTVVPPAYSMVTAGSEY
Sbjct: 1021 ETESDLTYGEVEQRLDLLQEQLNRLESQMTTDIQTILQLLQKQTTVVPPAYSMVTAGSEY 1080

Query: 1081 QRPIIQLMRTSQPEASIKTDRSFSPSSQCPEFLDLEKSKLKSKESLSSGVHLNTASEDNL 1140
            QRPIIQLMRTSQPEASIKTDRSFSPSSQCPEFLDLEKSKLKSKESLSSGVHLNTASEDNL
Sbjct: 1081 QRPIIQLMRTSQPEASIKTDRSFSPSSQCPEFLDLEKSKLKSKESLSSGVHLNTASEDNL 1140

Query: 1141 TSLLKQDSDLSLELHLRQRKTYVHPIRHPSLPDSSLSTVGIVGLHRHVSDPGLPGK 1196
            TSLLKQDSDLSLELHLRQRKTYVHPIRHPSLPDSSLSTVGIVGLHRHVSDPGLPGK
Sbjct: 1141 TSLLKQDSDLSLELHLRQRKTYVHPIRHPSLPDSSLSTVGIVGLHRHVSDPGLPGK 1196


>gi|27886665 potassium voltage-gated channel, subfamily H, member 7
           isoform 2 [Homo sapiens]
          Length = 732

 Score = 1434 bits (3711), Expect = 0.0
 Identities = 712/719 (99%), Positives = 712/719 (99%), Gaps = 7/719 (0%)

Query: 1   MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVM 60
           MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVM
Sbjct: 1   MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVM 60

Query: 61  QKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEG 120
           QKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEG
Sbjct: 61  QKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEG 120

Query: 121 VAMMFIINFEYVTDNENAATPERVNPILPIKTVNRKFFGFKFPGLRVLTYRKQSLPQEDP 180
           VAMMFIINFEYVTDNENAATPERVNPILPIKTVNRKFFGFKFPGLRVLTYRKQSLPQEDP
Sbjct: 121 VAMMFIINFEYVTDNENAATPERVNPILPIKTVNRKFFGFKFPGLRVLTYRKQSLPQEDP 180

Query: 181 DVVVIDSSKHSDDSVAMKHFKSPTKESCSPSEADDTKALIQPSKCSPLVNISGPLDHSSP 240
           DVVVIDSSKHSDDSVAMKHFKSPTKESCSPSEADDTKALIQPSKCSPLVNISGPLDHSSP
Sbjct: 181 DVVVIDSSKHSDDSVAMKHFKSPTKESCSPSEADDTKALIQPSKCSPLVNISGPLDHSSP 240

Query: 241 KRQWDRLYPDMLQSSSQLSHSRSRESLCSIRRASSVHDIEGFGVHPKNIFRDRHASEDNG 300
           KRQWDRLYPDMLQSSSQLSHSRSRESLCSIRRASSVHDIEGFGVHPKNIFRDRHASE   
Sbjct: 241 KRQWDRLYPDMLQSSSQLSHSRSRESLCSIRRASSVHDIEGFGVHPKNIFRDRHASE--- 297

Query: 301 RNVKGPFNHIKSSLLGSTSDSNLNKYSTINKIPQLTLNFSEVKTEKKNSSPPSSDKTIIA 360
               GPFNHIKSSLLGSTSDSNLNKYSTINKIPQLTLNFSEVKTEKKNSSPPSSDKTIIA
Sbjct: 298 ----GPFNHIKSSLLGSTSDSNLNKYSTINKIPQLTLNFSEVKTEKKNSSPPSSDKTIIA 353

Query: 361 PKVKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIY 420
           PKVKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIY
Sbjct: 354 PKVKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIY 413

Query: 421 TAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEE 480
           TAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEE
Sbjct: 414 TAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEE 473

Query: 481 VVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARK 540
           VVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARK
Sbjct: 474 VVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARK 533

Query: 541 LDRYSEYGAAVLMLLMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYN 600
           LDRYSEYGAAVLMLLMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYN
Sbjct: 534 LDRYSEYGAAVLMLLMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYN 593

Query: 601 DSDSSSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFG 660
           DSDSSSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFG
Sbjct: 594 DSDSSSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFG 653

Query: 661 NVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMV 719
           NVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMV
Sbjct: 654 NVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMV 712


>gi|4557729 voltage-gated potassium channel, subfamily H, member 2
            isoform a [Homo sapiens]
          Length = 1159

 Score = 1234 bits (3192), Expect = 0.0
 Identities = 679/1113 (61%), Positives = 795/1113 (71%), Gaps = 69/1113 (6%)

Query: 1    MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVM 60
            MPVRRGHVAPQNTFL TIIRKFEGQ++KFIIANARV+NCA+IYCNDGFCE+ G+SR +VM
Sbjct: 1    MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVM 60

Query: 61   QKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEG 120
            Q+PCTCDFLHGP T+R   AQIAQALLG+EERKVE+ +Y K+GS F+C   ++PVKN++G
Sbjct: 61   QRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDG 120

Query: 121  VAMMFIINFEYVTDNENAATP-----ERVNPILPIKTVNRKFFGFKFPGLRVLTYRKQSL 175
              +MFI+NFE V + +   +P      R  P   +     K F  K P L  LT R+ S+
Sbjct: 121  AVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSV 180

Query: 176  PQED------PDVVVID----SSKHSDDSVAMKHFKSPTKESCSPSEADDTKALIQPSKC 225
                      P  VV+D     +  S +S+A+    +          A++ +AL+ P   
Sbjct: 181  RSGGAGGAGAPGAVVVDVDLTPAAPSSESLALDEVTAMDNHVAGLGPAEERRALVGPG-- 238

Query: 226  SPLVNISGPLDHSSPKRQWDRLYPDMLQSSSQLSHSRSRESLCSIRRASSVHDIEGF--G 283
            SP  +  G L    P  +   L PD   SS  L+ +RSRES  S+RRASS  DIE    G
Sbjct: 239  SPPRSAPGQL----PSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAG 294

Query: 284  VHPKNIFRDRHASEDNGRNVKGPFNHIKSSLLGSTSDSNLNKYSTINKIPQLTLNFSEVK 343
            V P      RHAS        G  + ++S LL STSDS+L +Y TI+KIPQ+TLNF ++K
Sbjct: 295  VLPPP---PRHAST-------GAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLK 344

Query: 344  TEKKNSSPPSSDKTIIAPKVKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHY 403
             +   +SP +SD+ IIAPK+K+RTHNVTEKVTQVLSLGADVLPEYKLQ PRI+++TILHY
Sbjct: 345  GDPFLASP-TSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHY 403

Query: 404  SPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREE-QKRRECGYSCSPLNVVDLIVDIMF 462
            SPFKAVWDWLILLLVIYTA+FTPYSAAFLL + EE     ECGY+C PL VVDLIVDIMF
Sbjct: 404  SPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMF 463

Query: 463  IIDILINFRTTYVNQNEEVVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDETTTL 522
            I+DILINFRTTYVN NEEVVS P +IA+HYFKGWFLIDMVAAIPFDLLIFGSGS+E   L
Sbjct: 464  IVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEE---L 520

Query: 523  IGLLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFALIAHWLACIWYAIGNVERPYLT 582
            IGLLKTARLLRLVRVARKLDRYSEYGAAVL LLMC FALIAHWLACIWYAIGN+E+P++ 
Sbjct: 521  IGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMD 580

Query: 583  DKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKI 642
             +IGWL +LG QIGK YN S    GPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKI
Sbjct: 581  SRIGWLHNLGDQIGKPYNSS-GLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKI 639

Query: 643  FSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEE 702
            FSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYH QMLRV+EFIRFHQIPNPLRQRLEE
Sbjct: 640  FSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEE 699

Query: 703  YFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFK 762
            YFQHAW+YTNGIDMN VLKGFPECLQADICLHLN++LLQ+CK FRGA+KGCLRALAMKFK
Sbjct: 700  YFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFK 759

Query: 763  TTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDDIVVAILGKNDIFGEMVHLYAKPGKSN 822
            TTHAPPGDTLVH GD+LTALYF+SRGSIEIL+ D+VVAILGKNDIFGE ++LYA+PGKSN
Sbjct: 760  TTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSN 819

Query: 823  ADVRALTYCDLHKIQREDLLEVLDMYPEFSDHFLTNLELTFNLRHESAKADLLRSQSMND 882
             DVRALTYCDLHKI R+DLLEVLDMYPEFSDHF ++LE+TFNLR  +    +  S    +
Sbjct: 820  GDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDTNM---IPGSPGSTE 876

Query: 883  SEGDNCKLRRRKLSFESEGEKENSTNDPEDSADTIRHYQSSKRH------FEEKKSRSSS 936
             EG   + R+RKLSF    +K+        +    R              + E  S   S
Sbjct: 877  LEGGFSRQRKRKLSFRRRTDKDTEQPGEVSALGPGRAGAGPSSRGRPGGPWGESPSSGPS 936

Query: 937  FISSIDDEQK----------PLFSGIVDSSPGIGKASGLDFEETV----PTSGRMHIDKR 982
               S +DE            P  S      P  G+    D E++     P SG       
Sbjct: 937  SPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKSSDTCNPLSGAFSGVSN 996

Query: 983  SHSCKDITDMRSWERENAHPQPEDSSPSALQRAAWGISETESDLTYGEVEQRLDLLQEQL 1042
              S    +  R ++     P P   +PS L         +      G+VE RLD LQ QL
Sbjct: 997  IFSFWGDSRGRQYQELPRCPAP---TPSLLNIPL----SSPGRRPRGDVESRLDALQRQL 1049

Query: 1043 NRLESQMTTDIQTILQLLQKQTTVVPPAYSMVT 1075
            NRLE++++ D+ T+LQLLQ+Q T+VPPAYS VT
Sbjct: 1050 NRLETRLSADMATVLQLLQRQMTLVPPAYSAVT 1082


>gi|26051271 voltage-gated potassium channel, subfamily H, member 2
           isoform b [Homo sapiens]
          Length = 888

 Score = 1075 bits (2780), Expect = 0.0
 Identities = 563/821 (68%), Positives = 645/821 (78%), Gaps = 39/821 (4%)

Query: 1   MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVM 60
           MPVRRGHVAPQNTFL TIIRKFEGQ++KFIIANARV+NCA+IYCNDGFCE+ G+SR +VM
Sbjct: 1   MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVM 60

Query: 61  QKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEG 120
           Q+PCTCDFLHGP T+R   AQIAQALLG+EERKVE+ +Y K+GS F+C   ++PVKN++G
Sbjct: 61  QRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDG 120

Query: 121 VAMMFIINFEYVTDNENAATP-----ERVNPILPIKTVNRKFFGFKFPGLRVLTYRKQSL 175
             +MFI+NFE V + +   +P      R  P   +     K F  K P L  LT R+ S+
Sbjct: 121 AVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSV 180

Query: 176 PQED------PDVVVID----SSKHSDDSVAMKHFKSPTKESCSPSEADDTKALIQPSKC 225
                     P  VV+D     +  S +S+A+    +          A++ +AL+ P   
Sbjct: 181 RSGGAGGAGAPGAVVVDVDLTPAAPSSESLALDEVTAMDNHVAGLGPAEERRALVGPG-- 238

Query: 226 SPLVNISGPLDHSSPKRQWDRLYPDMLQSSSQLSHSRSRESLCSIRRASSVHDIEGF--G 283
           SP  +  G L    P  +   L PD   SS  L+ +RSRES  S+RRASS  DIE    G
Sbjct: 239 SPPRSAPGQL----PSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAG 294

Query: 284 VHPKNIFRDRHASEDNGRNVKGPFNHIKSSLLGSTSDSNLNKYSTINKIPQLTLNFSEVK 343
           V P      RHAS        G  + ++S LL STSDS+L +Y TI+KIPQ+TLNF ++K
Sbjct: 295 VLPPP---PRHAST-------GAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLK 344

Query: 344 TEKKNSSPPSSDKTIIAPKVKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHY 403
            +   +SP +SD+ IIAPK+K+RTHNVTEKVTQVLSLGADVLPEYKLQ PRI+++TILHY
Sbjct: 345 GDPFLASP-TSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHY 403

Query: 404 SPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREE-QKRRECGYSCSPLNVVDLIVDIMF 462
           SPFKAVWDWLILLLVIYTA+FTPYSAAFLL + EE     ECGY+C PL VVDLIVDIMF
Sbjct: 404 SPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMF 463

Query: 463 IIDILINFRTTYVNQNEEVVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDETTTL 522
           I+DILINFRTTYVN NEEVVS P +IA+HYFKGWFLIDMVAAIPFDLLIFGSGS+E   L
Sbjct: 464 IVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEE---L 520

Query: 523 IGLLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFALIAHWLACIWYAIGNVERPYLT 582
           IGLLKTARLLRLVRVARKLDRYSEYGAAVL LLMC FALIAHWLACIWYAIGN+E+P++ 
Sbjct: 521 IGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMD 580

Query: 583 DKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKI 642
            +IGWL +LG QIGK YN S    GPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKI
Sbjct: 581 SRIGWLHNLGDQIGKPYNSS-GLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKI 639

Query: 643 FSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEE 702
           FSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYH QMLRV+EFIRFHQIPNPLRQRLEE
Sbjct: 640 FSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEE 699

Query: 703 YFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFK 762
           YFQHAW+YTNGIDMN VLKGFPECLQADICLHLN++LLQ+CK FRGA+KGCLRALAMKFK
Sbjct: 700 YFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFK 759

Query: 763 TTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDDIVVAILG 803
           TTHAPPGDTLVH GD+LTALYF+SRGSIEIL+ D+VVAILG
Sbjct: 760 TTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILG 800


>gi|13540549 potassium voltage-gated channel, subfamily H, member 6
           isoform 1 [Homo sapiens]
          Length = 994

 Score =  918 bits (2373), Expect = 0.0
 Identities = 450/542 (83%), Positives = 492/542 (90%)

Query: 325 KYSTINKIPQLTLNFSEVKTEKKNSSPPSSDKTIIAPKVKDRTHNVTEKVTQVLSLGADV 384
           KY TI++IPQ TLNF E   EK  SS  +  + I   KV +RT NVTEKVTQVLSLGADV
Sbjct: 174 KYRTISQIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADV 233

Query: 385 LPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRREC 444
           LPEYKLQ PRI+++TILHYSPFKAVWDWLILLLVIYTA+FTPYSAAFLL+D++E +R  C
Sbjct: 234 LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGAC 293

Query: 445 GYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFKGWFLIDMVAA 504
            Y+CSPL VVDLIVDIMF++DI+INFRTTYVN N+EVVS P +IA+HYFKGWFLIDMVAA
Sbjct: 294 SYTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAA 353

Query: 505 IPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFALIAH 564
           IPFDLLIF +GSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVL LLMC FALIAH
Sbjct: 354 IPFDLLIFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAH 413

Query: 565 WLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSS 624
           WLACIWYAIGNVERPYL  KIGWLDSLG Q+GKRYN SD +SGPS++DKYVTALYFTFSS
Sbjct: 414 WLACIWYAIGNVERPYLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSS 473

Query: 625 LTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVK 684
           LTSVGFGNVSPNTNSEK+FSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYH QMLRVK
Sbjct: 474 LTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVK 533

Query: 685 EFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCK 744
           EFIRFHQIPNPLRQRLEEYFQHAW+YTNGIDMN VLKGFPECLQADICLHL++ LLQ+C 
Sbjct: 534 EFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCP 593

Query: 745 AFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDDIVVAILGK 804
           AF GA KGCLRALA+KFKTTHAPPGDTLVH GDVL+ LYF+SRGSIEIL+DD+VVAILGK
Sbjct: 594 AFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGK 653

Query: 805 NDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQREDLLEVLDMYPEFSDHFLTNLELTFN 864
           NDIFGE V L+A+PGKS+ADVRALTYCDLHKIQR DLLEVLDMYP F++ F + LE+TFN
Sbjct: 654 NDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFN 713

Query: 865 LR 866
           LR
Sbjct: 714 LR 715



 Score =  194 bits (492), Expect = 5e-49
 Identities = 85/130 (65%), Positives = 111/130 (85%)

Query: 1   MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVM 60
           MPVRRGHVAPQNT+L TIIRKFEGQ++KF+IANA+++NCAIIYCNDGFCE+ G+SR +VM
Sbjct: 1   MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVM 60

Query: 61  QKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEG 120
           Q+PCTCDFL GP T    ++++AQALLG+EE KV++ YY K+ S+F C   ++PVKN++G
Sbjct: 61  QQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDG 120

Query: 121 VAMMFIINFE 130
             +MFI+NFE
Sbjct: 121 AVIMFILNFE 130


>gi|26051273 voltage-gated potassium channel, subfamily H, member 2
            isoform c [Homo sapiens]
          Length = 819

 Score =  903 bits (2334), Expect = 0.0
 Identities = 485/721 (67%), Positives = 546/721 (75%), Gaps = 35/721 (4%)

Query: 376  QVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLND 435
            +VLSLGADVLPEYKLQ PRI+++TILHYSPFKAVWDWLILLLVIYTA+FTPYSAAFLL +
Sbjct: 36   EVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKE 95

Query: 436  REE-QKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFK 494
             EE     ECGY+C PL VVDLIVDIMFI+DILINFRTTYVN NEEVVS P +IA+HYFK
Sbjct: 96   TEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFK 155

Query: 495  GWFLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLML 554
            GWFLIDMVAAIPFDLLIFGSGS+E   LIGLLKTARLLRLVRVARKLDRYSEYGAAVL L
Sbjct: 156  GWFLIDMVAAIPFDLLIFGSGSEE---LIGLLKTARLLRLVRVARKLDRYSEYGAAVLFL 212

Query: 555  LMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKY 614
            LMC FALIAHWLACIWYAIGN+E+P++  +IGWL +LG QIGK YN S    GPSIKDKY
Sbjct: 213  LMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSS-GLGGPSIKDKY 271

Query: 615  VTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTA 674
            VTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTA
Sbjct: 272  VTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTA 331

Query: 675  RYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLH 734
            RYH QMLRV+EFIRFHQIPNPLRQRLEEYFQHAW+YTNGIDMN VLKGFPECLQADICLH
Sbjct: 332  RYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLH 391

Query: 735  LNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILK 794
            LN++LLQ+CK FRGA+KGCLRALAMKFKTTHAPPGDTLVH GD+LTALYF+SRGSIEIL+
Sbjct: 392  LNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILR 451

Query: 795  DDIVVAILGKNDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQREDLLEVLDMYPEFSDH 854
             D+VVAILGKNDIFGE ++LYA+PGKSN DVRALTYCDLHKI R+DLLEVLDMYPEFSDH
Sbjct: 452  GDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDH 511

Query: 855  FLTNLELTFNLRHESAKADLLRSQSMNDSEGDNCKLRRRKLSFESEGEKENSTNDPEDSA 914
            F ++LE+TFNLR  +    +  S    + EG   + R+RKLSF    +K+        + 
Sbjct: 512  FWSSLEITFNLRDTNM---IPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTEQPGEVSAL 568

Query: 915  DTIRHYQSSKRH------FEEKKSRSSSFISSIDDEQK----------PLFSGIVDSSPG 958
               R              + E  S   S   S +DE            P  S      P 
Sbjct: 569  GPGRAGAGPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPP 628

Query: 959  IGKASGLDFEETV----PTSGRMHIDKRSHSCKDITDMRSWERENAHPQPEDSSPSALQR 1014
             G+    D E++     P SG         S    +  R ++     P P   +PS L  
Sbjct: 629  GGEPLMEDCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAP---TPSLLNI 685

Query: 1015 AAWGISETESDLTYGEVEQRLDLLQEQLNRLESQMTTDIQTILQLLQKQTTVVPPAYSMV 1074
                   +      G+VE RLD LQ QLNRLE++++ D+ T+LQLLQ+Q T+VPPAYS V
Sbjct: 686  PL----SSPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAV 741

Query: 1075 T 1075
            T
Sbjct: 742  T 742


>gi|27886651 potassium voltage-gated channel, subfamily H, member 6
           isoform 2 [Homo sapiens]
          Length = 905

 Score =  786 bits (2030), Expect = 0.0
 Identities = 402/542 (74%), Positives = 441/542 (81%), Gaps = 53/542 (9%)

Query: 325 KYSTINKIPQLTLNFSEVKTEKKNSSPPSSDKTIIAPKVKDRTHNVTEKVTQVLSLGADV 384
           KY TI++IPQ TLNF E   EK  SS  +  + I   KV +RT NVTEKVTQVLSLGADV
Sbjct: 174 KYRTISQIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADV 233

Query: 385 LPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRREC 444
           LPEYKLQ PRI+++TILHYSPFKAVWDWLILLLVIYTA+FTPYSAAFLL+D++E +R  C
Sbjct: 234 LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGAC 293

Query: 445 GYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFKGWFLIDMVAA 504
            Y+CSPL VVDLIVDIMF++DI+INFRTTYVN N+EVVS P +IA+HYFKGWFLIDMVAA
Sbjct: 294 SYTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAA 353

Query: 505 IPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFALIAH 564
           IPFDLLIF +GSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVL LLMC FALIAH
Sbjct: 354 IPFDLLIFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAH 413

Query: 565 WLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSS 624
                                 WL  +                                S
Sbjct: 414 ----------------------WLACI-------------------------------CS 420

Query: 625 LTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVK 684
           LTSVGFGNVSPNTNSEK+FSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYH QMLRVK
Sbjct: 421 LTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVK 480

Query: 685 EFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCK 744
           EFIRFHQIPNPLRQRLEEYFQHAW+YTNGIDMN VLKGFPECLQADICLHL++ LLQ+C 
Sbjct: 481 EFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCP 540

Query: 745 AFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDDIVVAILGK 804
           AF GA KGCLRALA+KFKTTHAPPGDTLVH GDVL+ LYF+SRGSIEIL+DD+VVAILGK
Sbjct: 541 AFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGK 600

Query: 805 NDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQREDLLEVLDMYPEFSDHFLTNLELTFN 864
           NDIFGE V L+A+PGKS+ADVRALTYCDLHKIQR DLLEVLDMYP F++ F + LE+TFN
Sbjct: 601 NDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFN 660

Query: 865 LR 866
           LR
Sbjct: 661 LR 662



 Score =  194 bits (492), Expect = 5e-49
 Identities = 85/130 (65%), Positives = 111/130 (85%)

Query: 1   MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVM 60
           MPVRRGHVAPQNT+L TIIRKFEGQ++KF+IANA+++NCAIIYCNDGFCE+ G+SR +VM
Sbjct: 1   MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVM 60

Query: 61  QKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEG 120
           Q+PCTCDFL GP T    ++++AQALLG+EE KV++ YY K+ S+F C   ++PVKN++G
Sbjct: 61  QQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDG 120

Query: 121 VAMMFIINFE 130
             +MFI+NFE
Sbjct: 121 AVIMFILNFE 130


>gi|27886667 potassium voltage-gated channel, subfamily H, member 8
            [Homo sapiens]
          Length = 1107

 Score =  500 bits (1287), Expect = e-141
 Identities = 300/771 (38%), Positives = 448/771 (58%), Gaps = 57/771 (7%)

Query: 373  KVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFL 432
            K+   + +     PEYK+   + +KF +LH+S FKA WDWLILL   Y A+  PY+  F+
Sbjct: 187  KINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFI 246

Query: 433  LNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHY 492
             ND     R           V D+ V+I+FIIDI++NFRTTYV+++ +V+ +   I IHY
Sbjct: 247  GNDDLSTTRST--------TVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHY 298

Query: 493  FKGWFLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVL 552
               WF+ID++AA+PFDLL   + +    +L+ LLKT RLLRL+R+ +KLDRYS++   VL
Sbjct: 299  VTTWFIIDLIAALPFDLLY--AFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVL 356

Query: 553  MLLMCIFALIAHWLACIWYAIGNVERP---YLTDKIGWLDSLGQQIGKRYNDSDSSSGPS 609
             LLM +FAL+AHW+ACIWY IG +ER     L  ++GWL  LG+++   Y  +++  GPS
Sbjct: 357  TLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPS 416

Query: 610  IKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRL 669
            I+  Y+ ALYFT SSLTSVGFGNVS NT++EKIFSIC MLIG+LM+A +FGNV+AIIQR+
Sbjct: 417  IRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRM 476

Query: 670  YSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQA 729
            YS  + YH +   +K+FIR H +P  L+QR+ EYFQ  W+  NGID N +LK FP+ L++
Sbjct: 477  YSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRS 536

Query: 730  DICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGS 789
            DI +HLN+ +LQ    F  AS+GCLR+L++  KT+   PG+ L+  GD L A+YF+  GS
Sbjct: 537  DITMHLNKEILQ-LSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGS 595

Query: 790  IEILKDDIVVAILGKNDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQREDLLEVLDMYP 849
            +E+LKD +V+AILGK D+ G  + +  +  K+NADV+ALTYCDL  I  + L EVLD+YP
Sbjct: 596  MEVLKDSMVLAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYP 655

Query: 850  EFSDHFLTNL--ELTFNLR--HESAKADLLRSQSM---NDSEGDNCKLRRRKLSFESEGE 902
            E++  F+ ++  +LT+NLR  HES     L ++SM   ++ +G+    +R     E E E
Sbjct: 656  EYAHKFVEDIQHDLTYNLREGHESDVISRLSNKSMVSQSEPKGNGNINKRLPSIVEDEEE 715

Query: 903  KENSTNDPEDSADTIRHYQSSKRHFEEKKSRSSSFISSIDDEQKPLFSGIVDSSPGIGKA 962
            +E    +   S   I    SS R+  +K   + +++       K L SG V     I + 
Sbjct: 716  EEEGEEEEAVSLSPICTRGSSSRN--KKVGSNKAYLGL---SLKQLASGTVPFHSPI-RV 769

Query: 963  SGLDFEETVPTSGRMHIDKRSHSCKDITDMRSWERENAHPQPEDSSPSALQRAAWGISET 1022
            S  +  +T     +  ID  +H+ +   +++       +  P D SP  +     G S  
Sbjct: 770  SRSNSPKT-----KQEIDPPNHNKRKEKNLKLQLSTLNNAGPPDLSPRIVDGIEDGNSSE 824

Query: 1023 ESDLTYGEVEQRL------------------------DLLQEQLNRLESQMTTDIQTILQ 1058
            ES  T+    +R+                        +  ++Q+N+L S++TT  Q + Q
Sbjct: 825  ESQ-TFDFGSERIRSEPRISPPLGDPEIGAAVLFIKAEETKQQINKLNSEVTTLTQEVSQ 883

Query: 1059 LLQKQTTVVPPAYSMVTAGSEYQRPIIQLMRTSQPEASIKTDRSFSPSSQC 1109
            L +    V+    ++++     +   +          S++T  S+S    C
Sbjct: 884  LGKDMRNVIQLLENVLSPQQPSRFCSLHSTSVCPSRESLQTRTSWSAHQPC 934



 Score =  143 bits (360), Expect = 1e-33
 Identities = 68/143 (47%), Positives = 98/143 (68%), Gaps = 1/143 (0%)

Query: 1   MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARV-QNCAIIYCNDGFCEMTGFSRPDV 59
           MPV +G +APQNTFL TI  +F+G +  FI+ANA+V +   I+YC+DGFCE+ GF+R +V
Sbjct: 1   MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEV 60

Query: 60  MQKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQE 119
           MQK C+C FL G ET    + QI ++L    E K E+ +Y KNGS F C   I+P+KN++
Sbjct: 61  MQKSCSCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEK 120

Query: 120 GVAMMFIINFEYVTDNENAATPE 142
           G  ++F+ +F+ +TD +   TPE
Sbjct: 121 GDVVLFLASFKDITDTKVKITPE 143


>gi|4504831 potassium voltage-gated channel, subfamily H, member 1
           isoform 2 [Homo sapiens]
          Length = 962

 Score =  472 bits (1214), Expect = e-132
 Identities = 243/519 (46%), Positives = 345/519 (66%), Gaps = 22/519 (4%)

Query: 359 IAPKV-KDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLL 417
           +AP V K    +   ++ +VL LG+D+LP+YK + P+     ILHY  FK  WDW+IL+L
Sbjct: 168 LAPSVQKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILIL 227

Query: 418 VIYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQ 477
             YTAI  PY+ +F        K R+   +     VVD IVD++F++DI++NF TT+V  
Sbjct: 228 TFYTAILVPYNVSF--------KTRQNNVAWL---VVDSIVDVIFLVDIVLNFHTTFVGP 276

Query: 478 NEEVVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDE-TTTLIGLLKTARLLRLVR 536
             EV+SDP  I ++Y K WF+ID+++ +P+D++      DE  ++L   LK  RLLRL R
Sbjct: 277 AGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEGISSLFSSLKVVRLLRLGR 336

Query: 537 VARKLDRYSEYGAAVLMLLMCIFALIAHWLACIWYAIGNVERPYLTDKI----GWLDSLG 592
           VARKLD Y EYGAAVL+LL+C+F L AHW+ACIWY+IG+ E      K      WL  L 
Sbjct: 337 VARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLA 396

Query: 593 QQIGKRYNDSDSSSG-----PSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICV 647
             IG  Y  + S SG     PS    Y+++LYFT +SLTSVGFGN++P+T+ EKIF++ +
Sbjct: 397 MDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAI 456

Query: 648 MLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHA 707
           M+IGSL+YA+IFGNV+ I Q++Y+ T RYH  +  V++F++ +Q+P  L +R+ +Y    
Sbjct: 457 MMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVST 516

Query: 708 WTYTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAP 767
           W+ + GID   VL+  P+ ++ADIC+HLN+ + +   AFR AS GCLRALAM+F+T H  
Sbjct: 517 WSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCA 576

Query: 768 PGDTLVHCGDVLTALYFLSRGSIEILKDDIVVAILGKNDIFGEMVHLYAKPGKSNADVRA 827
           PGD + H G+ + +L F+  GS+E+++DD VVAILGK D+FG++    A   +S A+VRA
Sbjct: 577 PGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRA 636

Query: 828 LTYCDLHKIQREDLLEVLDMYPEFSDHFLTNLELTFNLR 866
           LTYCDLH I+R+ L +VL+ Y  FS  F  NL LT+NLR
Sbjct: 637 LTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLR 675



 Score =  100 bits (249), Expect = 8e-21
 Identities = 48/130 (36%), Positives = 76/130 (58%), Gaps = 2/130 (1%)

Query: 4   RRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVMQKP 63
           RRG VAPQNTFL  I+R+    N  F++ NA++ +  I+Y NDGFC+++G+ R +VMQK 
Sbjct: 7   RRGLVAPQNTFLENIVRRSNDTN--FVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKS 64

Query: 64  CTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEGVAM 123
            TC F++G  T +  I ++ Q     E    E+  Y KN +       I P++N++   +
Sbjct: 65  STCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVV 124

Query: 124 MFIINFEYVT 133
           +F+  F  +T
Sbjct: 125 LFLCTFSDIT 134


>gi|22024390 potassium voltage-gated channel, subfamily H, member 5
           isoform 1 [Homo sapiens]
          Length = 988

 Score =  470 bits (1209), Expect = e-132
 Identities = 239/517 (46%), Positives = 343/517 (66%), Gaps = 20/517 (3%)

Query: 359 IAPKVKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLV 418
           + P  K    +   ++ +VL LG+D+LP+YK + P+     ILHY  FK  WDW+IL+L 
Sbjct: 166 LTPMNKTEVVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILT 225

Query: 419 IYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQN 478
            YTAI  PY+ +F      + K+    +      V+D +VD++F++DI++NF TT+V   
Sbjct: 226 FYTAIMVPYNVSF------KTKQNNIAWL-----VLDSVVDVIFLVDIVLNFHTTFVGPG 274

Query: 479 EEVVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDE-TTTLIGLLKTARLLRLVRV 537
            EV+SDP  I ++Y K WF+ID+++ +P+D++      DE  ++L   LK  RLLRL RV
Sbjct: 275 GEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRV 334

Query: 538 ARKLDRYSEYGAAVLMLLMCIFALIAHWLACIWYAIGNVER-PYLTDKI---GWLDSLGQ 593
           ARKLD Y EYGAAVL+LL+C+F L+AHWLACIWY+IG+ E    +T+ I    WL  L  
Sbjct: 335 ARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLAL 394

Query: 594 QIGK--RYNDSDS--SSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVML 649
            IG   RYN S      GPS    YV++LYFT +SLT++GFGN++P T+ EK+FS+ +M+
Sbjct: 395 SIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMM 454

Query: 650 IGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWT 709
           +GSL+YA+IFGNV+ I Q++Y+ T RYH  +  V++F++ +Q+P  L +R+ +Y    W+
Sbjct: 455 VGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWS 514

Query: 710 YTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPG 769
            + GID   VL   P+ ++ADIC+HLN+ +     AFR AS GCLRALA++F+T H  PG
Sbjct: 515 MSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPG 574

Query: 770 DTLVHCGDVLTALYFLSRGSIEILKDDIVVAILGKNDIFGEMVHLYAKPGKSNADVRALT 829
           D + H G+ + AL F+  GS+E+++DD VVAILGK D+FG++         + A+VRALT
Sbjct: 575 DLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALT 634

Query: 830 YCDLHKIQREDLLEVLDMYPEFSDHFLTNLELTFNLR 866
           YCDLH I+RE LL+VLD Y  F++ F  NL LT NLR
Sbjct: 635 YCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLR 671



 Score = 98.6 bits (244), Expect = 3e-20
 Identities = 47/130 (36%), Positives = 75/130 (57%), Gaps = 2/130 (1%)

Query: 4   RRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVMQKP 63
           +RG VAPQNTFL  I+R+       F++ NA++ +  ++Y NDGFC+++G+ R DVMQK 
Sbjct: 5   KRGLVAPQNTFLENIVRR--SSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKS 62

Query: 64  CTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEGVAM 123
            TC F++G  T +  I ++ Q     E    EV  Y KN +       I P++N+    +
Sbjct: 63  STCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVV 122

Query: 124 MFIINFEYVT 133
           +F+  F+ +T
Sbjct: 123 LFLCTFKDIT 132


>gi|27886648 potassium voltage-gated channel, subfamily H, member 5
           isoform 2 [Homo sapiens]
          Length = 624

 Score =  470 bits (1209), Expect = e-132
 Identities = 239/517 (46%), Positives = 343/517 (66%), Gaps = 20/517 (3%)

Query: 359 IAPKVKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLV 418
           + P  K    +   ++ +VL LG+D+LP+YK + P+     ILHY  FK  WDW+IL+L 
Sbjct: 108 LTPMNKTEVVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILT 167

Query: 419 IYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQN 478
            YTAI  PY+ +F      + K+    +      V+D +VD++F++DI++NF TT+V   
Sbjct: 168 FYTAIMVPYNVSF------KTKQNNIAWL-----VLDSVVDVIFLVDIVLNFHTTFVGPG 216

Query: 479 EEVVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDE-TTTLIGLLKTARLLRLVRV 537
            EV+SDP  I ++Y K WF+ID+++ +P+D++      DE  ++L   LK  RLLRL RV
Sbjct: 217 GEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRV 276

Query: 538 ARKLDRYSEYGAAVLMLLMCIFALIAHWLACIWYAIGNVER-PYLTDKI---GWLDSLGQ 593
           ARKLD Y EYGAAVL+LL+C+F L+AHWLACIWY+IG+ E    +T+ I    WL  L  
Sbjct: 277 ARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLAL 336

Query: 594 QIGK--RYNDSDS--SSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVML 649
            IG   RYN S      GPS    YV++LYFT +SLT++GFGN++P T+ EK+FS+ +M+
Sbjct: 337 SIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMM 396

Query: 650 IGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWT 709
           +GSL+YA+IFGNV+ I Q++Y+ T RYH  +  V++F++ +Q+P  L +R+ +Y    W+
Sbjct: 397 VGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWS 456

Query: 710 YTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPG 769
            + GID   VL   P+ ++ADIC+HLN+ +     AFR AS GCLRALA++F+T H  PG
Sbjct: 457 MSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPG 516

Query: 770 DTLVHCGDVLTALYFLSRGSIEILKDDIVVAILGKNDIFGEMVHLYAKPGKSNADVRALT 829
           D + H G+ + AL F+  GS+E+++DD VVAILGK D+FG++         + A+VRALT
Sbjct: 517 DLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALT 576

Query: 830 YCDLHKIQREDLLEVLDMYPEFSDHFLTNLELTFNLR 866
           YCDLH I+RE LL+VLD Y  F++ F  NL LT NLR
Sbjct: 577 YCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLR 613



 Score = 44.3 bits (103), Expect = 7e-04
 Identities = 22/74 (29%), Positives = 36/74 (48%)

Query: 60  MQKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQE 119
           MQK  TC F++G  T +  I ++ Q     E    EV  Y KN +       I P++N+ 
Sbjct: 1   MQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEH 60

Query: 120 GVAMMFIINFEYVT 133
              ++F+  F+ +T
Sbjct: 61  EKVVLFLCTFKDIT 74


>gi|27437001 potassium voltage-gated channel, subfamily H, member 1
           isoform 1 [Homo sapiens]
          Length = 989

 Score =  462 bits (1190), Expect = e-130
 Identities = 243/546 (44%), Positives = 346/546 (63%), Gaps = 49/546 (8%)

Query: 359 IAPKV-KDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLL 417
           +AP V K    +   ++ +VL LG+D+LP+YK + P+     ILHY  FK  WDW+IL+L
Sbjct: 168 LAPSVQKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILIL 227

Query: 418 VIYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQ 477
             YTAI  PY+ +F        K R+   +     VVD IVD++F++DI++NF TT+V  
Sbjct: 228 TFYTAILVPYNVSF--------KTRQNNVAWL---VVDSIVDVIFLVDIVLNFHTTFVGP 276

Query: 478 NEEVVSDPAKIAIHYFKGWFLIDMVAAIPFDLL--------------------------- 510
             EV+SDP  I ++Y K WF+ID+++ +P+D++                           
Sbjct: 277 AGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPP 336

Query: 511 -IFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFALIAHWLACI 569
            + G  S   ++L   LK  RLLRL RVARKLD Y EYGAAVL+LL+C+F L AHW+ACI
Sbjct: 337 PLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACI 396

Query: 570 WYAIGNVERPYLTDKI----GWLDSLGQQIGKRYNDSDSSS-----GPSIKDKYVTALYF 620
           WY+IG+ E      K      WL  L   IG  Y  + S S     GPS    Y+++LYF
Sbjct: 397 WYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYF 456

Query: 621 TFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQM 680
           T +SLTSVGFGN++P+T+ EKIF++ +M+IGSL+YA+IFGNV+ I Q++Y+ T RYH  +
Sbjct: 457 TMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEML 516

Query: 681 LRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLL 740
             V++F++ +Q+P  L +R+ +Y    W+ + GID   VL+  P+ ++ADIC+HLN+ + 
Sbjct: 517 NSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVF 576

Query: 741 QNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDDIVVA 800
           +   AFR AS GCLRALAM+F+T H  PGD + H G+ + +L F+  GS+E+++DD VVA
Sbjct: 577 KEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVA 636

Query: 801 ILGKNDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQREDLLEVLDMYPEFSDHFLTNLE 860
           ILGK D+FG++    A   +S A+VRALTYCDLH I+R+ L +VL+ Y  FS  F  NL 
Sbjct: 637 ILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLI 696

Query: 861 LTFNLR 866
           LT+NLR
Sbjct: 697 LTYNLR 702



 Score =  100 bits (249), Expect = 8e-21
 Identities = 48/130 (36%), Positives = 76/130 (58%), Gaps = 2/130 (1%)

Query: 4   RRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVMQKP 63
           RRG VAPQNTFL  I+R+    N  F++ NA++ +  I+Y NDGFC+++G+ R +VMQK 
Sbjct: 7   RRGLVAPQNTFLENIVRRSNDTN--FVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKS 64

Query: 64  CTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEGVAM 123
            TC F++G  T +  I ++ Q     E    E+  Y KN +       I P++N++   +
Sbjct: 65  STCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVV 124

Query: 124 MFIINFEYVT 133
           +F+  F  +T
Sbjct: 125 LFLCTFSDIT 134


>gi|6912446 potassium voltage-gated channel, subfamily H, member 4
           [Homo sapiens]
          Length = 1017

 Score =  454 bits (1168), Expect = e-127
 Identities = 246/508 (48%), Positives = 339/508 (66%), Gaps = 28/508 (5%)

Query: 385 LPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRREC 444
           +PEYK+ +   ++  +LHYS  KA+WD LILL   Y A+  PY+  F  +D      R  
Sbjct: 204 VPEYKVASVGGSRCLLLHYSVSKAIWDGLILLATFYVAVTVPYNVCFSGDDDTPITSRHT 263

Query: 445 GYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFKGWFLIDMVAA 504
             S       D+ V+++FI+DI++NFRTTYV+Q+ +V+S P  I +HY   WF ID++AA
Sbjct: 264 LVS-------DIAVEMLFILDIILNFRTTYVSQSGQVISAPRSIGLHYLATWFFIDLIAA 316

Query: 505 IPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFALIAH 564
           +PFDLL   + +   T+L+ LLKT RLLRL+R+ +KL+RYS+  A VL LLM +FAL+AH
Sbjct: 317 LPFDLLYIFNIT--VTSLVHLLKTVRLLRLLRLLQKLERYSQCSAVVLTLLMSVFALLAH 374

Query: 565 WLACIWYAIGNVER----PYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYF 620
           W+ACIWY IG  E     P L D IGWL  LG+++   Y +  S  GPS +  Y+ ALYF
Sbjct: 375 WMACIWYVIGRREMEANDPLLWD-IGWLHELGKRLEVPYVNG-SVGGPSRRSAYIAALYF 432

Query: 621 TFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQM 680
           T SSLTSVGFGNV  NT++EKIFSIC MLIG+LM+A +FGNV+AIIQR+YS  + YH +M
Sbjct: 433 TLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRM 492

Query: 681 LRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLL 740
             +K+FIR H++P PL+QR+ EYFQ  W   +GID N +L+ FP+ L+ADI +HLN+ +L
Sbjct: 493 KDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREIL 552

Query: 741 QNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDDIVVA 800
           Q    F  AS+GCLRAL++  KT+   PG+ L+  GD L A Y++  GS+E+L+D++V+A
Sbjct: 553 Q-LPLFGAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMVLA 611

Query: 801 ILGKNDIFG-EMVHLYAKPG---------KSNADVRALTYCDLHKIQREDLLEVLDMYPE 850
           ILGK D+ G ++     +PG         K++ADV+ALTYC L ++    L EVL +YPE
Sbjct: 612 ILGKGDLIGADIPEPGQEPGLGADPNFVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPE 671

Query: 851 FSDHFLTNL--ELTFNLRHESAKADLLR 876
           +   F   L  +LTFNLR  S  + L R
Sbjct: 672 YGAAFRAGLPRDLTFNLRQGSDTSGLSR 699



 Score =  139 bits (349), Expect = 2e-32
 Identities = 60/136 (44%), Positives = 96/136 (70%), Gaps = 1/136 (0%)

Query: 1   MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANAR-VQNCAIIYCNDGFCEMTGFSRPDV 59
           MPV +G +APQNTFL TI  +F+G +  F++ANA+  +   I+YC+DGFCE+TG+ R +V
Sbjct: 1   MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEV 60

Query: 60  MQKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQE 119
           MQK C+C FL+GPET    + ++ +AL G +E + E+ +Y K+GS F C   ++P+KN+ 
Sbjct: 61  MQKTCSCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEM 120

Query: 120 GVAMMFIINFEYVTDN 135
           G  ++F+ +F+ +T +
Sbjct: 121 GEVVLFLFSFKDITQS 136


>gi|38569493 potassium voltage-gated channel, subfamily H
           (eag-related), member 3 [Homo sapiens]
          Length = 1083

 Score =  422 bits (1086), Expect = e-118
 Identities = 234/533 (43%), Positives = 327/533 (61%), Gaps = 46/533 (8%)

Query: 385 LPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRREC 444
           LPEYK+   R + F +LH    +A WD  ILL  +Y A+  PYS             RE 
Sbjct: 202 LPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAVTVPYSVCV-------STAREP 254

Query: 445 GYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFKGWFLIDMVAA 504
             +  P +V DL V+++FI+DI++NFRTT+V+++ +VV  P  I +HY   WFL+D++AA
Sbjct: 255 SAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYVTTWFLLDVIAA 314

Query: 505 IPFDLLIFGSGSDETTTLIG--LLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFALI 562
           +PFDLL     + +     G  LLKT RLLRL+R+  +LDRYS+Y A VL LLM +FAL+
Sbjct: 315 LPFDLL----HAFKVNVYFGAHLLKTVRLLRLLRLLPRLDRYSQYSAVVLTLLMAVFALL 370

Query: 563 AHWLACIWYAIGNVERPYLTDK---IGWLDSLGQQIGKRY---------------NDSDS 604
           AHW+AC+W+ IG  E      +   IGWL  L +++   Y               +D+ S
Sbjct: 371 AHWVACVWFYIGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSDNCS 430

Query: 605 SS------------GPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGS 652
           SS            GPS++  Y+T+LYF  SSLTSVGFGNVS NT++EKIFSIC MLIG+
Sbjct: 431 SSSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGA 490

Query: 653 LMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTN 712
           LM+A +FGNV+AIIQR+Y+    YH +   ++++IR H+IP PL+QR+ EYFQ  W   N
Sbjct: 491 LMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNN 550

Query: 713 GIDMNMVLKGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTL 772
           GID   +L+  P+ L+ADI +HL++ +LQ    F  AS+GCLRAL++  +     PG+ L
Sbjct: 551 GIDTTELLQSLPDELRADIAMHLHKEVLQ-LPLFEAASRGCLRALSLALRPAFCTPGEYL 609

Query: 773 VHCGDVLTALYFLSRGSIEILKDDIVVAILGKNDIFGEMVHLYAKPGKSNADVRALTYCD 832
           +H GD L ALYF+  GS+E+LK   V+AILGK D+ G  +    +  K+NADV+ LTYC 
Sbjct: 610 IHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIGCELPRREQVVKANADVKGLTYCV 669

Query: 833 LHKIQREDLLEVLDMYPEFSDHFLTNL--ELTFNLRHESAKADLLRSQSMNDS 883
           L  +Q   L + L +YPEF+  F   L  EL++NL      A++  S    D+
Sbjct: 670 LQCLQLAGLHDSLALYPEFAPRFSRGLRGELSYNLGAGGGSAEVDTSSLSGDN 722



 Score =  135 bits (339), Expect = 3e-31
 Identities = 61/144 (42%), Positives = 95/144 (65%), Gaps = 1/144 (0%)

Query: 1   MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNC-AIIYCNDGFCEMTGFSRPDV 59
           MP  RG +APQNTFL TI  +F+G +  F++ NA+V     ++YC+DGFC++TGFSR +V
Sbjct: 1   MPAMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEV 60

Query: 60  MQKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQE 119
           MQ+ C C FL+GP+T      QI +AL   +E K E+  Y K+G  F C   +IP+KN++
Sbjct: 61  MQRGCACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEK 120

Query: 120 GVAMMFIINFEYVTDNENAATPER 143
           G   +F+++ + +++ +N   P+R
Sbjct: 121 GEVALFLVSHKDISETKNRGGPDR 144


>gi|27886646 potassium voltage-gated channel, subfamily H, member 5
           isoform 3 [Homo sapiens]
          Length = 611

 Score =  408 bits (1048), Expect = e-113
 Identities = 205/453 (45%), Positives = 300/453 (66%), Gaps = 20/453 (4%)

Query: 359 IAPKVKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLV 418
           + P  K    +   ++ +VL LG+D+LP+YK + P+     ILHY  FK  WDW+IL+L 
Sbjct: 166 LTPMNKTEVVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILT 225

Query: 419 IYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQN 478
            YTAI  PY+ +F      + K+    +      V+D +VD++F++DI++NF TT+V   
Sbjct: 226 FYTAIMVPYNVSF------KTKQNNIAWL-----VLDSVVDVIFLVDIVLNFHTTFVGPG 274

Query: 479 EEVVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDE-TTTLIGLLKTARLLRLVRV 537
            EV+SDP  I ++Y K WF+ID+++ +P+D++      DE  ++L   LK  RLLRL RV
Sbjct: 275 GEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRV 334

Query: 538 ARKLDRYSEYGAAVLMLLMCIFALIAHWLACIWYAIGNVER-PYLTDKI---GWLDSLGQ 593
           ARKLD Y EYGAAVL+LL+C+F L+AHWLACIWY+IG+ E    +T+ I    WL  L  
Sbjct: 335 ARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLAL 394

Query: 594 QIGK--RYNDSDS--SSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVML 649
            IG   RYN S      GPS    YV++LYFT +SLT++GFGN++P T+ EK+FS+ +M+
Sbjct: 395 SIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMM 454

Query: 650 IGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWT 709
           +GSL+YA+IFGNV+ I Q++Y+ T RYH  +  V++F++ +Q+P  L +R+ +Y    W+
Sbjct: 455 VGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWS 514

Query: 710 YTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPG 769
            + GID   VL   P+ ++ADIC+HLN+ +     AFR AS GCLRALA++F+T H  PG
Sbjct: 515 MSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPG 574

Query: 770 DTLVHCGDVLTALYFLSRGSIEILKDDIVVAIL 802
           D + H G+ + AL F+  GS+E+++DD VVAIL
Sbjct: 575 DLIYHAGESVDALCFVVSGSLEVIQDDEVVAIL 607



 Score = 98.6 bits (244), Expect = 3e-20
 Identities = 47/130 (36%), Positives = 75/130 (57%), Gaps = 2/130 (1%)

Query: 4   RRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVMQKP 63
           +RG VAPQNTFL  I+R+       F++ NA++ +  ++Y NDGFC+++G+ R DVMQK 
Sbjct: 5   KRGLVAPQNTFLENIVRR--SSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKS 62

Query: 64  CTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEGVAM 123
            TC F++G  T +  I ++ Q     E    EV  Y KN +       I P++N+    +
Sbjct: 63  STCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVV 122

Query: 124 MFIINFEYVT 133
           +F+  F+ +T
Sbjct: 123 LFLCTFKDIT 132


>gi|4885407 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 4 [Homo sapiens]
          Length = 1203

 Score =  178 bits (451), Expect = 3e-44
 Identities = 130/483 (26%), Positives = 225/483 (46%), Gaps = 52/483 (10%)

Query: 398 FTILH-YSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDL 456
           F I+H YS F+  WD  +LLL++   I  P    F  ++           + +P  V ++
Sbjct: 252 FWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDE-----------NTTPWIVFNV 300

Query: 457 IVDIMFIIDILINFRT-TYVNQNEEVVSDPAKIAIHYFKGWFLIDMVAAIPFD--LLIFG 513
           + D  F+ID+++NFRT   V  N E++ DP +I + Y K WF++D +++IP D   LI  
Sbjct: 301 VSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVE 360

Query: 514 SGSDET-------------TTLIGLLKTARLLRLVRVARKLDR-----YSEYGAAVLML- 554
           +  D               T ++ LL+  RL RL+R   + +      Y    A V ++ 
Sbjct: 361 TRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVN 420

Query: 555 LMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKY 614
           L+ +  L+ HW  C+ + +     P L D   + D     I    N+S          +Y
Sbjct: 421 LIGMMLLLCHWDGCLQFLV-----PMLQD---FPDDCWVSINNMVNNSWGK-------QY 465

Query: 615 VTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTA 674
             AL+   S +  +G+G  +P   S+   ++  M++G+  YA   G+ +A+IQ L S   
Sbjct: 466 SYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRR 525

Query: 675 RYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLH 734
           +Y  +  +V++++ FH++P   RQR+ +Y++H +      D   +L    E L+ +I   
Sbjct: 526 QYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRY-QGKMFDEESILGELSEPLREEIINF 584

Query: 735 LNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILK 794
             + L+ +   F  A    + ++  K +     PGD ++  G +   +YF+  G + +L 
Sbjct: 585 NCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLT 644

Query: 795 DDIVVAILGKNDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQREDLLEVLDMYPEFSDH 854
                  L     FGE+  L    G+  A VRA TYC L+ +  ++  EVL+ YP     
Sbjct: 645 KGNKETKLADGSYFGEICLL--TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRA 702

Query: 855 FLT 857
           F T
Sbjct: 703 FET 705


>gi|156071470 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 2 [Homo sapiens]
          Length = 889

 Score =  173 bits (439), Expect = 8e-43
 Identities = 126/483 (26%), Positives = 223/483 (46%), Gaps = 56/483 (11%)

Query: 400 ILH-YSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIV 458
           I+H YS F+  WD+ +LL ++   I  P    F  ++           + +P  V +++ 
Sbjct: 203 IIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDE-----------TTAPWIVFNVVS 251

Query: 459 DIMFIIDILINFRTTYV-NQNEEVVSDPAKIAIHYFKGWFLIDMVAAIPFD--LLIFGSG 515
           D  F++D+++NFRT  V   N E++ DP KI   Y + WF++D V++IP D   LI   G
Sbjct: 252 DTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDYIFLIVEKG 311

Query: 516 SDET-------------TTLIGLLKTARLLRLVRVARKLDR--YSEYGAAVLMLLMC--- 557
            D               T ++ LL+  RL RL+R   + +   +  Y  A  ++ +C   
Sbjct: 312 IDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICNLI 371

Query: 558 -IFALIAHWLACIWYAIGNVERPYLTD--KIGWLDSLGQQIGKRYNDSDSSSGPSIKDKY 614
            +  L+ HW  C+ + +     P L D  +  W+   G                S  + Y
Sbjct: 372 SMMLLLCHWDGCLQFLV-----PMLQDFPRNCWVSINGMV------------NHSWSELY 414

Query: 615 VTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTA 674
             AL+   S +  +G+G  +P + ++   ++  M++G+  YA   G+ +A+IQ L S   
Sbjct: 415 SFALFKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRR 474

Query: 675 RYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLH 734
           +Y  +  +V++++ FH++P   RQ++ +Y++H +      D + +L      L+ +I   
Sbjct: 475 QYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRY-QGKMFDEDSILGELNGPLREEIVNF 533

Query: 735 LNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILK 794
             + L+ +   F  A    + A+  K K     PGD ++  G +   +YF+  G + +L 
Sbjct: 534 NCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLT 593

Query: 795 DDIVVAILGKNDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQREDLLEVLDMYPEFSDH 854
                  L     FGE+  L    G+  A VRA TYC L+ +  ++  EVL+ YP     
Sbjct: 594 KGNKEMKLSDGSYFGEICLL--TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRA 651

Query: 855 FLT 857
           F T
Sbjct: 652 FET 654


>gi|116325989 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 1 [Homo sapiens]
          Length = 890

 Score =  171 bits (434), Expect = 3e-42
 Identities = 123/483 (25%), Positives = 227/483 (46%), Gaps = 52/483 (10%)

Query: 398 FTILH-YSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDL 456
           F I+H YS F+  WD ++L++++   +  P    F               + +P  + ++
Sbjct: 132 FWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQ-----------TTTPWIIFNV 180

Query: 457 IVDIMFIIDILINFRTTYVNQNE-EVVSDPAKIAIHYFKGWFLIDMVAAIPFD--LLIFG 513
             D +F++D+++NFRT  VN++  E++ DP  I ++Y K WF++D +++IP D   LI  
Sbjct: 181 ASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVE 240

Query: 514 SGSDET-------------TTLIGLLKTARLLRLVRVARKLDRYS----EYGAAVLML-- 554
            G D               T ++ LL+  RL RL+R   + +       +  +AV+ +  
Sbjct: 241 KGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFN 300

Query: 555 LMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKY 614
           L+ +  L+ HW  C+ + +     P L D   +       + +  NDS          +Y
Sbjct: 301 LIGMMLLLCHWDGCLQFLV-----PLLQD---FPPDCWVSLNEMVNDSWGK-------QY 345

Query: 615 VTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTA 674
             AL+   S +  +G+G  +P + S+   ++  M++G+  YA   G+ +A+IQ L S   
Sbjct: 346 SYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRR 405

Query: 675 RYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLH 734
           +Y  +  +V++++ FH++P  +RQ++ +Y++H +      D   +L    + L+ +I   
Sbjct: 406 QYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRY-QGKIFDEENILNELNDPLREEIVNF 464

Query: 735 LNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILK 794
             + L+     F  A    + A+  K +     PGD ++  G V   +YF+  G   ++ 
Sbjct: 465 NCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVIT 524

Query: 795 DDIVVAILGKNDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQREDLLEVLDMYPEFSDH 854
                  L     FGE+  L    G+  A VRA TYC L+ +  ++  EVL+ YP     
Sbjct: 525 KSSKEMKLTDGSYFGEICLL--TKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRA 582

Query: 855 FLT 857
           F T
Sbjct: 583 FET 585


>gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2
           [Homo sapiens]
          Length = 676

 Score =  163 bits (413), Expect = 8e-40
 Identities = 112/409 (27%), Positives = 203/409 (49%), Gaps = 31/409 (7%)

Query: 453 VVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHY-FKGWFLIDMVAAIPFDLLI 511
           V+D   D+++++D+L+  RT ++ Q   +VSD  ++  HY     F +D+++ +P DL  
Sbjct: 187 VLDYSADVLYVLDVLVRARTGFLEQGL-MVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 245

Query: 512 FGSGSDETTTLIG-LLKTARLLRLVRVARKLDRYSEY---GAAVLMLLMCIFALIAHWLA 567
              G++        LLK +RL            Y      G  VL +L     +I HW A
Sbjct: 246 LKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYIL-----IIIHWNA 300

Query: 568 CIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSLTS 627
           CI++AI      + TD   W+          Y +        +  KY+ +LY++  +LT+
Sbjct: 301 CIYFAISKFIG-FGTDS--WV----------YPNISIPEHGRLSRKYIYSLYWSTLTLTT 347

Query: 628 VGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFI 687
           +G     P  + E +F +   L+G L++A+I GNV ++I  + +  A +  ++  +K+++
Sbjct: 348 IG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYM 406

Query: 688 RFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCKAFR 747
           +F ++   L  R+  +F + W     +D   VLK  P+ L+A+I ++++   L+  + F+
Sbjct: 407 QFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQ 466

Query: 748 GASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDDIVV--AILGKN 805
               G L  L +K + T   PGD +   GD+   +Y ++ G + ++ DD V    +L   
Sbjct: 467 DCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDG 526

Query: 806 DIFGEMVHLYAKPGKS----NADVRALTYCDLHKIQREDLLEVLDMYPE 850
             FGE+  L  K  KS     A++R++ Y DL  + ++DL+E L  YPE
Sbjct: 527 SYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPE 575


>gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Homo
           sapiens]
          Length = 694

 Score =  163 bits (413), Expect = 8e-40
 Identities = 112/409 (27%), Positives = 203/409 (49%), Gaps = 31/409 (7%)

Query: 453 VVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHY-FKGWFLIDMVAAIPFDLLI 511
           V+D   D+++++D+L+  RT ++ Q   +VSD  ++  HY     F +D+++ +P DL  
Sbjct: 205 VLDYSADVLYVLDVLVRARTGFLEQGL-MVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 263

Query: 512 FGSGSDETTTLIG-LLKTARLLRLVRVARKLDRYSEY---GAAVLMLLMCIFALIAHWLA 567
              G++        LLK +RL            Y      G  VL +L     +I HW A
Sbjct: 264 LKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYIL-----IIIHWNA 318

Query: 568 CIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSLTS 627
           CI++AI      + TD   W+          Y +        +  KY+ +LY++  +LT+
Sbjct: 319 CIYFAISKFIG-FGTDS--WV----------YPNISIPEHGRLSRKYIYSLYWSTLTLTT 365

Query: 628 VGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFI 687
           +G     P  + E +F +   L+G L++A+I GNV ++I  + +  A +  ++  +K+++
Sbjct: 366 IG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYM 424

Query: 688 RFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCKAFR 747
           +F ++   L  R+  +F + W     +D   VLK  P+ L+A+I ++++   L+  + F+
Sbjct: 425 QFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQ 484

Query: 748 GASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDDIVV--AILGKN 805
               G L  L +K + T   PGD +   GD+   +Y ++ G + ++ DD V    +L   
Sbjct: 485 DCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDG 544

Query: 806 DIFGEMVHLYAKPGKS----NADVRALTYCDLHKIQREDLLEVLDMYPE 850
             FGE+  L  K  KS     A++R++ Y DL  + ++DL+E L  YPE
Sbjct: 545 SYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPE 593


>gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1
           [Homo sapiens]
          Length = 759

 Score =  162 bits (409), Expect = 2e-39
 Identities = 139/556 (25%), Positives = 256/556 (46%), Gaps = 47/556 (8%)

Query: 304 KGPFNHIKSSLLGSTSDSNLNKYSTINKIPQLTLNFSEVKTEKKNSSPPSSDKTIIA--P 361
           KG  +  +  L G+ +  N+N  S  ++ P+      E K +KK     S DK      P
Sbjct: 142 KGGPSQREQYLPGAIALFNVNNSSNKDQEPE------EKKKKKKEKKSKSDDKNENKNDP 195

Query: 362 KVKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYT 421
           + K +  +  +K  +  S   D   E K +   I+     +Y+     W + I L V+Y 
Sbjct: 196 EKKKKKKDKEKKKKEEKS--KDKKEEEKKEVVVIDPSGNTYYN-----WLFCITLPVMYN 248

Query: 422 AIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEV 481
                  A F     +E +     Y      ++D + DI+++ID+ +  RT Y+ Q   V
Sbjct: 249 WTMVIARACF-----DELQSDYLEYWL----ILDYVSDIVYLIDMFVRTRTGYLEQGLLV 299

Query: 482 VSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKL 541
             +   I  +     F +D+++ IP DLL F  G +     I L +  R  R+    ++ 
Sbjct: 300 KEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPE--IRLNRLLRFSRMFEFFQRT 357

Query: 542 DRYSEYGAAV-LMLLMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYN 600
           +  + Y     +  L+    +I HW AC++Y+I           IG+ +         Y 
Sbjct: 358 ETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKA--------IGFGNDTWV-----YP 404

Query: 601 DSDSSSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFG 660
           D +      +  KYV +LY++  +LT++G     P  +SE +F +   LIG L++A+I G
Sbjct: 405 DINDPEFGRLARKYVYSLYWSTLTLTTIG-ETPPPVRDSEYVFVVVDFLIGVLIFATIVG 463

Query: 661 NVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVL 720
           N+ ++I  + +  A +  ++  +K+++ F  +   + +R+ ++F + WT    +D   VL
Sbjct: 464 NIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVL 523

Query: 721 KGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLT 780
           K  P+ L+A+I ++++   L+  + F     G L  L +K +     PGD +   GD+  
Sbjct: 524 KYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGR 583

Query: 781 ALYFLSRGSIEILKDDIVV--AILGKNDIFGEMVHLYAKPGKS----NADVRALTYCDLH 834
            +Y +  G + ++ DD V    +L     FGE+  L  K  K+     A+++++ Y DL 
Sbjct: 584 EMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLF 643

Query: 835 KIQREDLLEVLDMYPE 850
            + ++DL+E L  YP+
Sbjct: 644 CLSKDDLMEALTEYPD 659


>gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [Homo
           sapiens]
          Length = 690

 Score =  162 bits (409), Expect = 2e-39
 Identities = 139/556 (25%), Positives = 256/556 (46%), Gaps = 47/556 (8%)

Query: 304 KGPFNHIKSSLLGSTSDSNLNKYSTINKIPQLTLNFSEVKTEKKNSSPPSSDKTIIA--P 361
           KG  +  +  L G+ +  N+N  S  ++ P+      E K +KK     S DK      P
Sbjct: 73  KGGPSQREQYLPGAIALFNVNNSSNKDQEPE------EKKKKKKEKKSKSDDKNENKNDP 126

Query: 362 KVKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYT 421
           + K +  +  +K  +  S   D   E K +   I+     +Y+     W + I L V+Y 
Sbjct: 127 EKKKKKKDKEKKKKEEKS--KDKKEEEKKEVVVIDPSGNTYYN-----WLFCITLPVMYN 179

Query: 422 AIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEV 481
                  A F     +E +     Y      ++D + DI+++ID+ +  RT Y+ Q   V
Sbjct: 180 WTMVIARACF-----DELQSDYLEYWL----ILDYVSDIVYLIDMFVRTRTGYLEQGLLV 230

Query: 482 VSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKL 541
             +   I  +     F +D+++ IP DLL F  G +     I L +  R  R+    ++ 
Sbjct: 231 KEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPE--IRLNRLLRFSRMFEFFQRT 288

Query: 542 DRYSEYGAAV-LMLLMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYN 600
           +  + Y     +  L+    +I HW AC++Y+I           IG+ +         Y 
Sbjct: 289 ETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKA--------IGFGNDTWV-----YP 335

Query: 601 DSDSSSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFG 660
           D +      +  KYV +LY++  +LT++G     P  +SE +F +   LIG L++A+I G
Sbjct: 336 DINDPEFGRLARKYVYSLYWSTLTLTTIG-ETPPPVRDSEYVFVVVDFLIGVLIFATIVG 394

Query: 661 NVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVL 720
           N+ ++I  + +  A +  ++  +K+++ F  +   + +R+ ++F + WT    +D   VL
Sbjct: 395 NIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVL 454

Query: 721 KGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLT 780
           K  P+ L+A+I ++++   L+  + F     G L  L +K +     PGD +   GD+  
Sbjct: 455 KYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGR 514

Query: 781 ALYFLSRGSIEILKDDIVV--AILGKNDIFGEMVHLYAKPGKS----NADVRALTYCDLH 834
            +Y +  G + ++ DD V    +L     FGE+  L  K  K+     A+++++ Y DL 
Sbjct: 515 EMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLF 574

Query: 835 KIQREDLLEVLDMYPE 850
            + ++DL+E L  YP+
Sbjct: 575 CLSKDDLMEALTEYPD 590


>gi|38327037 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 3 [Homo sapiens]
          Length = 774

 Score =  157 bits (396), Expect = 7e-38
 Identities = 130/484 (26%), Positives = 217/484 (44%), Gaps = 56/484 (11%)

Query: 400 ILH-YSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIV 458
           I+H YS F+  WD ++LLL++   I  P    F    +EE           P  V +++ 
Sbjct: 85  IIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFF---KEENS--------PPWIVFNVLS 133

Query: 459 DIMFIIDILINFRT-TYVNQNEEVVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSD 517
           D  F++D+++NFRT   V +  E++  P  I   Y + WFL+D++++IP D  IF     
Sbjct: 134 DTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDY-IFLVVEL 192

Query: 518 ETTTLIGLLKTARLLRLVRVAR--------KLDRYSEY--------------GAAVLML- 554
           E      + KTAR LR+VR  +        +L R   Y               +AV+ + 
Sbjct: 193 EPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIF 252

Query: 555 -LMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDK 613
            L+ +  L+ HW  C+ + +     P L D   +       I    N S          +
Sbjct: 253 NLIGMMLLLCHWDGCLQFLV-----PMLQD---FPPDCWVSINHMVNHSWGR-------Q 297

Query: 614 YVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGT 673
           Y  AL+   S +  +G+G  +P    +   ++  M++G+  YA   G+ +A+IQ L S  
Sbjct: 298 YSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSR 357

Query: 674 ARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICL 733
            +Y  +  +V++++ FH++P   RQR+ EY++H +      D   +L    E L+ +I  
Sbjct: 358 RQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRY-QGKMFDEESILGELSEPLREEIIN 416

Query: 734 HLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEIL 793
              + L+ +   F  A    + A+  K +     PGD +V  G V   +YF+  G + +L
Sbjct: 417 FTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVL 476

Query: 794 KDDIVVAILGKNDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQREDLLEVLDMYPEFSD 853
                   L     FGE+  L    G+  A VRA TYC L+ +  +    VL+ +P    
Sbjct: 477 ARGARDTRLTDGSYFGEICLL--TRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRR 534

Query: 854 HFLT 857
            F T
Sbjct: 535 AFET 538


>gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]
          Length = 664

 Score =  154 bits (388), Expect = 6e-37
 Identities = 112/409 (27%), Positives = 199/409 (48%), Gaps = 31/409 (7%)

Query: 453 VVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFKGW-FLIDMVAAIPFDLLI 511
           V+D + D+++I D+ I  RT ++ Q   +V D  K+  +Y     F +D+ + IP DL+ 
Sbjct: 177 VLDYVSDVVYIADLFIRLRTGFLEQGL-LVKDTKKLRDNYIHTLQFKLDVASIIPTDLIY 235

Query: 512 FGSGSDETTTLIGLLKTARLLRLVRVARKLDRY---SEYGAAVLMLLMCIFAL-IAHWLA 567
           F             ++  RLL   R+    DR    + Y     +  + ++ L I HW A
Sbjct: 236 FAVDIHSPE-----VRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILVIIHWNA 290

Query: 568 CIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSLTS 627
           CI+YAI           IG+    G       N +D   G   ++ Y+  LY++  +LT+
Sbjct: 291 CIYYAISK--------SIGF----GVDTWVYPNITDPEYGYLARE-YIYCLYWSTLTLTT 337

Query: 628 VGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFI 687
           +G     P  + E +F I   LIG L++A+I GNV ++I  + +  A +  ++  VK ++
Sbjct: 338 IG-ETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYM 396

Query: 688 RFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCKAFR 747
           +F ++   +  ++  +F + WT    +D   +LK  P  L+A+I ++++ + L+  + F 
Sbjct: 397 QFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFH 456

Query: 748 GASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDDIVV--AILGKN 805
               G L  L +K +     PGD +   GD+   +Y +  G + ++ DD V   A+L   
Sbjct: 457 DCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAG 516

Query: 806 DIFGEMVHLYAKPGK----SNADVRALTYCDLHKIQREDLLEVLDMYPE 850
             FGE+  L  K  K      A++R+L Y DL  + ++DL+E +  YP+
Sbjct: 517 SCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPD 565


>gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]
          Length = 575

 Score =  144 bits (364), Expect = 4e-34
 Identities = 102/411 (24%), Positives = 199/411 (48%), Gaps = 35/411 (8%)

Query: 453 VVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFKGW-FLIDMVAAIPFDLLI 511
           V+D   D+++++D+++ F T ++ Q   VV D  +I+  Y + W F +D+ + +P D++ 
Sbjct: 71  VLDYTSDLLYLLDMVVRFHTGFLEQGILVV-DKGRISSRYVRTWSFFLDLASLMPTDVVY 129

Query: 512 FGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGA-----AVLMLLMCIFALIAHWL 566
              G    T     L+  R LR  R+    DR     A      +  L++ IF +I HW 
Sbjct: 130 VRLGPHTPT-----LRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVI-HWN 183

Query: 567 ACIWYAIGNVERPYLT-DKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSL 625
           +C+++A+      YL   +  W+          Y D        ++ +Y+ + YF+   L
Sbjct: 184 SCLYFALSR----YLGFGRDAWV----------YPDPAQPGFERLRRQYLYSFYFSTLIL 229

Query: 626 TSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKE 685
           T+VG     P    E +F +   L+  + +A+I G++S++I  + +  A ++     VK+
Sbjct: 230 TTVG-DTPPPAREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKK 288

Query: 686 FIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCKA 745
           +++   +   L +R+ +++QH        +   +L+  PE L+A++ + ++ + L   + 
Sbjct: 289 YMKLQHVNRKLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQI 348

Query: 746 FRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDDIVV--AILG 803
           F+      L  L +K +     PG+ +   GD+   +Y +  G + ++ DD +   A+LG
Sbjct: 349 FQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVLG 408

Query: 804 KNDIFGEMVHLYAKPGKS----NADVRALTYCDLHKIQREDLLEVLDMYPE 850
               FGE+  +  K   S     A++++L Y DL  + +EDL EVL  YP+
Sbjct: 409 AGLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQ 459


>gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]
          Length = 809

 Score =  102 bits (255), Expect = 2e-21
 Identities = 132/666 (19%), Positives = 264/666 (39%), Gaps = 72/666 (10%)

Query: 326 YSTINKIPQLTLNFSEVKTEKKNSSP---PSSDKTIIAPKVKDRTHNVTEKVTQVLSLGA 382
           ++ + ++ Q T  + +   E   SSP   P + K    P VK+     TE   ++L    
Sbjct: 133 HNLVKRMRQRTALYKKKLVEGDLSSPEASPQTAKPTAVPPVKESDDKPTEHYYRLLWFKV 192

Query: 383 DVLP--EY--KLQTPR-INKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDRE 437
             +P  EY  +++ P  I+ +T   Y     +W  L+ L   +   F P    F     +
Sbjct: 193 KKMPLTEYLKRIKLPNSIDSYTDRLY----LLWLLLVTLAYNWNCCFIPLRLVFPYQTAD 248

Query: 438 EQKRRECGYSCSPLNVVDLIVDIMFIIDIL-INFRTTYVNQNEEVVSDPAKIAIHYFKGW 496
                    +     + D+I DI+++ D+L I  R  +V +  +++ D  ++  HY    
Sbjct: 249 ---------NIHYWLIADIICDIIYLYDMLFIQPRLQFV-RGGDIIVDSNELRKHYRTST 298

Query: 497 -FLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLMLL 555
            F +D+ + IPFD+     G +       +LK             +   +     +    
Sbjct: 299 KFQLDVASIIPFDICYLFFGFNPMFRANRMLKYTSFFEFNHHLESIMDKAYIYRVIRTTG 358

Query: 556 MCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYV 615
             +F L  H  AC++Y   N E    T  +   D  G +                   Y+
Sbjct: 359 YLLFIL--HINACVYYWASNYEGIGTTRWV--YDGEGNE-------------------YL 395

Query: 616 TALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTAR 675
              Y+   +L ++G G   P T  E +F +     G  +++S+ G +  +I    +    
Sbjct: 396 RCYYWAVRTLITIG-GLPEPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNY 454

Query: 676 YHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHL 735
           +   M     ++  + IP  +++R+  ++++ W     +D + +LK  P  +Q  + + +
Sbjct: 455 FRACMDDTIAYMNNYSIPKLVQKRVRTWYEYTWDSQRMLDESDLLKTLPTTVQLALAIDV 514

Query: 736 NQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEIL-- 793
           N +++     F+G     +  + ++ K+    PGD +   G++   +Y +  G +++L  
Sbjct: 515 NFSIISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVLGG 574

Query: 794 -KDDIVVAILGKNDIFGEMVHLYAKPG-KSNADVRALTYCDLHKIQREDLLEVLDMYPEF 851
                V+  L    +FGE+  L A  G +  A+V A  + +L  + ++ L E+L  YP+ 
Sbjct: 575 PDGTKVLVTLKAGSVFGEISLLAAGGGNRRTANVVAHGFANLLTLDKKTLQEILVHYPDS 634

Query: 852 SDHFLTNLELTFNLRHESAKADLLRS----------------QSMNDSEGDNCKLRRRKL 895
               +    +    + ++A+A   R                 +++    G     R  KL
Sbjct: 635 ERILMKKARVLLKQKAKTAEATPPRKDLALLFPPKEETPKLFKTLLGGTGKASLARLLKL 694

Query: 896 SFESEGE-KENSTNDPE---DSADTIRHYQSSKRHFEEKKSRSSSFISSIDDEQKPLFSG 951
             E   + KENS    E   ++ D  +  +  ++  E+K   +       + E+KPL   
Sbjct: 695 KREQAAQKKENSEGGEEEGKENEDKQKENEDKQKENEDKGKENEDKDKGREPEEKPLDRP 754

Query: 952 IVDSSP 957
              +SP
Sbjct: 755 ECTASP 760


>gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [Homo
            sapiens]
          Length = 1251

 Score = 96.3 bits (238), Expect = 2e-19
 Identities = 77/404 (19%), Positives = 181/404 (44%), Gaps = 31/404 (7%)

Query: 453  VVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFKGW-FLIDMVAAIPFDLLI 511
            ++D + D+++ +DI +        +  ++++D   +  +Y K   F +D+++ +P D L 
Sbjct: 693  LMDYLCDLIYFLDITVFQTRLQFVRGGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLY 752

Query: 512  FGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFAL-IAHWLACIW 570
               G +             LLRL R  + +  + E+ + +  +L   +   +    A + 
Sbjct: 753  LKVGVNP------------LLRLPRCLKYM-AFFEFNSRLESILSKAYVYRVIRTTAYLL 799

Query: 571  YAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSLTSVGF 630
            Y++      +L   + +  S  Q +G  +   D      + + Y+   YF   +L ++G 
Sbjct: 800  YSL------HLNSCLYYWASAYQGLGSTHWVYDG-----VGNSYIRCYYFAVKTLITIG- 847

Query: 631  GNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFH 690
            G   P T  E +F +     G   ++ + G +  ++    +G   Y   M    +++ F+
Sbjct: 848  GLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFY 907

Query: 691  QIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCKAFRGAS 750
            +IP  ++ R++ ++++ W     +D + ++   P+ ++ D+ + +N  ++     F+G  
Sbjct: 908  KIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCD 967

Query: 751  KGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEIL---KDDIVVAILGKNDI 807
            +  +  +  + ++    P D +   G++   +Y +  G +++L       V+  L    +
Sbjct: 968  RQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSV 1027

Query: 808  FGEMVHLYAKPG-KSNADVRALTYCDLHKIQREDLLEVLDMYPE 850
            FGE+  L    G +  A+V A  + +L  + ++DL E+L  YPE
Sbjct: 1028 FGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPE 1071


>gi|205361107 potassium channel, subfamily K, member 17 isoform 2
           [Homo sapiens]
          Length = 271

 Score = 43.1 bits (100), Expect = 0.002
 Identities = 24/84 (28%), Positives = 51/84 (60%), Gaps = 3/84 (3%)

Query: 588 LDSLGQQIGKRYNDSDS--SSGPSI-KDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFS 644
           LDSL + + + Y +  S  S+  S+ + + V + +F+ S++T++G+GN+SPNT + ++F 
Sbjct: 74  LDSLIRDVVQAYKNGASLLSNTTSMGRWELVGSFFFSVSTITTIGYGNLSPNTMAARLFC 133

Query: 645 ICVMLIGSLMYASIFGNVSAIIQR 668
           I   L+G  +   +   +  ++Q+
Sbjct: 134 IFFALVGIPLNLVVLNRLGHLMQQ 157


>gi|17025230 potassium channel, subfamily K, member 17 isoform 1
           [Homo sapiens]
          Length = 332

 Score = 43.1 bits (100), Expect = 0.002
 Identities = 24/84 (28%), Positives = 51/84 (60%), Gaps = 3/84 (3%)

Query: 588 LDSLGQQIGKRYNDSDS--SSGPSI-KDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFS 644
           LDSL + + + Y +  S  S+  S+ + + V + +F+ S++T++G+GN+SPNT + ++F 
Sbjct: 74  LDSLIRDVVQAYKNGASLLSNTTSMGRWELVGSFFFSVSTITTIGYGNLSPNTMAARLFC 133

Query: 645 ICVMLIGSLMYASIFGNVSAIIQR 668
           I   L+G  +   +   +  ++Q+
Sbjct: 134 IFFALVGIPLNLVVLNRLGHLMQQ 157


>gi|4758630 potassium voltage-gated channel KQT-like protein 3 [Homo
           sapiens]
          Length = 872

 Score = 40.4 bits (93), Expect = 0.010
 Identities = 47/213 (22%), Positives = 92/213 (43%), Gaps = 36/213 (16%)

Query: 501 MVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFA 560
           ++A++P  ++  G+  +   T +  L+  ++LR++R+ R+   +   G+A+     C  +
Sbjct: 206 LIASVP--VVAVGNQGNVLATSLRSLRFLQILRMLRMDRRGGTWKLLGSAI-----CAHS 258

Query: 561 --LIAHWLACIWYAIGNVERPYLTDK-IGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTA 617
             LI  W       I +    YL +K +  +D+ G+++ + +            + Y  A
Sbjct: 259 KELITAWYIGFLTLILSSFLVYLVEKDVPEVDAQGEEMKEEF------------ETYADA 306

Query: 618 LYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYH 677
           L++   +L ++G+G+ +P T   ++ +    LIG   +A   G        L SG A   
Sbjct: 307 LWWGLITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFALPAG-------ILGSGLALKV 359

Query: 678 MQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTY 710
            +  R K F          R+   E  Q AW Y
Sbjct: 360 QEQHRQKHF-------EKRRKPAAELIQAAWRY 385


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.394 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,414,364
Number of Sequences: 37866
Number of extensions: 2043619
Number of successful extensions: 6823
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 60
Number of HSP's successfully gapped in prelim test: 74
Number of HSP's that attempted gapping in prelim test: 6459
Number of HSP's gapped (non-prelim): 350
length of query: 1196
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1082
effective length of database: 13,930,794
effective search space: 15073119108
effective search space used: 15073119108
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.