Search of human proteins with 27886651

Search of human proteins with 27886651

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|27886651 potassium voltage-gated channel, subfamily H,
member 6 isoform 2 [Homo sapiens]
         (905 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|27886651 potassium voltage-gated channel, subfamily H, member...  1837   0.0  
gi|13540549 potassium voltage-gated channel, subfamily H, member...  1779   0.0  
gi|4557729 voltage-gated potassium channel, subfamily H, member ...   813   0.0  
gi|27886653 potassium voltage-gated channel, subfamily H, member...   786   0.0  
gi|26051273 voltage-gated potassium channel, subfamily H, member...   759   0.0  
gi|26051271 voltage-gated potassium channel, subfamily H, member...   704   0.0  
gi|27886665 potassium voltage-gated channel, subfamily H, member...   479   e-135
gi|27886667 potassium voltage-gated channel, subfamily H, member...   476   e-134
gi|6912446 potassium voltage-gated channel, subfamily H, member ...   469   e-132
gi|22024390 potassium voltage-gated channel, subfamily H, member...   456   e-128
gi|4504831 potassium voltage-gated channel, subfamily H, member ...   426   e-119
gi|27437001 potassium voltage-gated channel, subfamily H, member...   416   e-116
gi|27886648 potassium voltage-gated channel, subfamily H, member...   400   e-111
gi|27886646 potassium voltage-gated channel, subfamily H, member...   396   e-110
gi|38569493 potassium voltage-gated channel, subfamily H (eag-re...   275   2e-73
gi|4885407 hyperpolarization activated cyclic nucleotide-gated p...   170   6e-42
gi|156071470 hyperpolarization activated cyclic nucleotide-gated...   168   2e-41
gi|116325989 hyperpolarization activated cyclic nucleotide-gated...   165   2e-40
gi|38327037 hyperpolarization activated cyclic nucleotide-gated ...   162   1e-39
gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2 [...   143   8e-34
gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Ho...   143   8e-34
gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1 [...   139   2e-32
gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [H...   139   2e-32
gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]    126   1e-28
gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]    121   3e-27
gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [H...    85   3e-16
gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]     79   1e-14
gi|45383011 potassium voltage-gated channel, delayed-rectifier, ...    45   3e-04
gi|6912444 potassium voltage-gated channel, subfamily G, member ...    42   0.003
gi|7657289 potassium channel, subfamily V, member 1 [Homo sapiens]     42   0.003

>gi|27886651 potassium voltage-gated channel, subfamily H, member 6
           isoform 2 [Homo sapiens]
          Length = 905

 Score = 1837 bits (4757), Expect = 0.0
 Identities = 905/905 (100%), Positives = 905/905 (100%)

Query: 1   MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVM 60
           MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVM
Sbjct: 1   MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVM 60

Query: 61  QQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDG 120
           QQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDG
Sbjct: 61  QQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDG 120

Query: 121 AVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQ 180
           AVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQ
Sbjct: 121 AVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQ 180

Query: 181 IPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKLQ 240
           IPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKLQ
Sbjct: 181 IPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKLQ 240

Query: 241 APRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPL 300
           APRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPL
Sbjct: 241 APRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPL 300

Query: 301 TVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLI 360
           TVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLI
Sbjct: 301 TVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLI 360

Query: 361 FRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACICS 420
           FRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACICS
Sbjct: 361 FRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACICS 420

Query: 421 LTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVK 480
           LTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVK
Sbjct: 421 LTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVK 480

Query: 481 EFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCP 540
           EFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCP
Sbjct: 481 EFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCP 540

Query: 541 AFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGK 600
           AFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGK
Sbjct: 541 AFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGK 600

Query: 601 NDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFN 660
           NDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFN
Sbjct: 601 NDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFN 660

Query: 661 LRDAAGGLHSSPRQAPGSQDHQGFFLSDNQSDAAPPLSISDASGLWPELLQEMPPRHSPQ 720
           LRDAAGGLHSSPRQAPGSQDHQGFFLSDNQSDAAPPLSISDASGLWPELLQEMPPRHSPQ
Sbjct: 661 LRDAAGGLHSSPRQAPGSQDHQGFFLSDNQSDAAPPLSISDASGLWPELLQEMPPRHSPQ 720

Query: 721 SPQEDPDCWPLKLGSRLEQLQAQMNRLESRVSSDLSRILQLLQKPMPQGHASYILEAPAS 780
           SPQEDPDCWPLKLGSRLEQLQAQMNRLESRVSSDLSRILQLLQKPMPQGHASYILEAPAS
Sbjct: 721 SPQEDPDCWPLKLGSRLEQLQAQMNRLESRVSSDLSRILQLLQKPMPQGHASYILEAPAS 780

Query: 781 NDLALVPIASETTSPGPRLPQGFLPPAQTPSYGDLDDCSPKHRNSSPRMPHLAVATDKTL 840
           NDLALVPIASETTSPGPRLPQGFLPPAQTPSYGDLDDCSPKHRNSSPRMPHLAVATDKTL
Sbjct: 781 NDLALVPIASETTSPGPRLPQGFLPPAQTPSYGDLDDCSPKHRNSSPRMPHLAVATDKTL 840

Query: 841 APSSEQEQPEGLWPPLASPLHPLEVQGLICGPCFSSLPEHLGSVPKQLDFQRHGSDPGFA 900
           APSSEQEQPEGLWPPLASPLHPLEVQGLICGPCFSSLPEHLGSVPKQLDFQRHGSDPGFA
Sbjct: 841 APSSEQEQPEGLWPPLASPLHPLEVQGLICGPCFSSLPEHLGSVPKQLDFQRHGSDPGFA 900

Query: 901 GSWGH 905
           GSWGH
Sbjct: 901 GSWGH 905


>gi|13540549 potassium voltage-gated channel, subfamily H, member 6
           isoform 1 [Homo sapiens]
          Length = 994

 Score = 1779 bits (4607), Expect = 0.0
 Identities = 901/994 (90%), Positives = 902/994 (90%), Gaps = 89/994 (8%)

Query: 1   MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVM 60
           MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVM
Sbjct: 1   MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVM 60

Query: 61  QQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDG 120
           QQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDG
Sbjct: 61  QQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDG 120

Query: 121 AVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQ 180
           AVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQ
Sbjct: 121 AVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQ 180

Query: 181 IPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKLQ 240
           IPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKLQ
Sbjct: 181 IPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKLQ 240

Query: 241 APRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPL 300
           APRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPL
Sbjct: 241 APRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPL 300

Query: 301 TVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLI 360
           TVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLI
Sbjct: 301 TVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLI 360

Query: 361 FRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAH------- 413
           FRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAH       
Sbjct: 361 FRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWY 420

Query: 414 ---------------WLACI-------------------------------CSLTSVGFG 427
                          WL  +                                SLTSVGFG
Sbjct: 421 AIGNVERPYLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFG 480

Query: 428 NVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQ 487
           NVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQ
Sbjct: 481 NVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQ 540

Query: 488 IPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGK 547
           IPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGK
Sbjct: 541 IPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGK 600

Query: 548 GCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEP 607
           GCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEP
Sbjct: 601 GCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEP 660

Query: 608 VSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFNLRDAAGG 667
           VSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFNLRDAAGG
Sbjct: 661 VSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFNLRDAAGG 720

Query: 668 LHSSPRQAPGSQDHQGFFLSDNQS------------------------------------ 691
           LHSSPRQAPGSQDHQGFFLSDNQS                                    
Sbjct: 721 LHSSPRQAPGSQDHQGFFLSDNQSGSPHELGPQFPSKGYSLLGPGSQNSMGAGPCAPGHP 780

Query: 692 DAAPPLSISDASGLWPELLQEMPPRHSPQSPQEDPDCWPLKLGSRLEQLQAQMNRLESRV 751
           DAAPPLSISDASGLWPELLQEMPPRHSPQSPQEDPDCWPLKLGSRLEQLQAQMNRLESRV
Sbjct: 781 DAAPPLSISDASGLWPELLQEMPPRHSPQSPQEDPDCWPLKLGSRLEQLQAQMNRLESRV 840

Query: 752 SSDLSRILQLLQKPMPQGHASYILEAPASNDLALVPIASETTSPGPRLPQGFLPPAQTPS 811
           SSDLSRILQLLQKPMPQGHASYILEAPASNDLALVPIASETTSPGPRLPQGFLPPAQTPS
Sbjct: 841 SSDLSRILQLLQKPMPQGHASYILEAPASNDLALVPIASETTSPGPRLPQGFLPPAQTPS 900

Query: 812 YGDLDDCSPKHRNSSPRMPHLAVATDKTLAPSSEQEQPEGLWPPLASPLHPLEVQGLICG 871
           YGDLDDCSPKHRNSSPRMPHLAVATDKTLAPSSEQEQPEGLWPPLASPLHPLEVQGLICG
Sbjct: 901 YGDLDDCSPKHRNSSPRMPHLAVATDKTLAPSSEQEQPEGLWPPLASPLHPLEVQGLICG 960

Query: 872 PCFSSLPEHLGSVPKQLDFQRHGSDPGFAGSWGH 905
           PCFSSLPEHLGSVPKQLDFQRHGSDPGFAGSWGH
Sbjct: 961 PCFSSLPEHLGSVPKQLDFQRHGSDPGFAGSWGH 994


>gi|4557729 voltage-gated potassium channel, subfamily H, member 2
           isoform a [Homo sapiens]
          Length = 1159

 Score =  813 bits (2099), Expect = 0.0
 Identities = 422/565 (74%), Positives = 456/565 (80%), Gaps = 62/565 (10%)

Query: 174 KYRTISQIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADV 233
           +YRTIS+IPQ TLNFV+   +   +S T++ EIIAP K+ ERT NVTEKVTQVLSLGADV
Sbjct: 326 RYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAP-KIKERTHNVTEKVTQVLSLGADV 384

Query: 234 LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGA- 292
           LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLL + +E      
Sbjct: 385 LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATE 444

Query: 293 CSYTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVA 352
           C Y C PL VVDLIVDIMF+VDI+INFRTTYVN N+EVVSHP RIAVHYFKGWFLIDMVA
Sbjct: 445 CGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVA 504

Query: 353 AIPFDLLIFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIA 412
           AIPFDLLIF +GS+E   LIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIA
Sbjct: 505 AIPFDLLIFGSGSEE---LIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIA 561

Query: 413 HWLACI----------------------------------------------------CS 420
           HWLACI                                                     S
Sbjct: 562 HWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSS 621

Query: 421 LTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVK 480
           LTSVGFGNVSPNTNSEK+FSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRV+
Sbjct: 622 LTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVR 681

Query: 481 EFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCP 540
           EFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHL+R+LLQHC 
Sbjct: 682 EFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCK 741

Query: 541 AFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGK 600
            F GA KGCLRALA+KFKTTHAPPGDTLVH GD+L+ LYFISRGSIEILR DVVVAILGK
Sbjct: 742 PFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGK 801

Query: 601 NDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFN 660
           NDIFGEP++L+A+PGKS+ DVRALTYCDLHKI R DLLEVLDMYP F++ FWS LE+TFN
Sbjct: 802 NDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFN 861

Query: 661 LRDAAGGLHSSPRQAPGSQDHQGFF 685
           LRD      +    +PGS + +G F
Sbjct: 862 LRDT-----NMIPGSPGSTELEGGF 881



 Score =  224 bits (570), Expect = 4e-58
 Identities = 106/130 (81%), Positives = 117/130 (90%)

Query: 1   MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVM 60
           MPVRRGHVAPQNT+LDTIIRKFEGQSRKF+IANA++ENCA+IYCNDGFCEL GYSR EVM
Sbjct: 1   MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVM 60

Query: 61  QQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDG 120
           Q+PCTCDFL GP T   A +++AQALLGAEE KV+I +YRKD S F CLVDVVPVKNEDG
Sbjct: 61  QRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDG 120

Query: 121 AVIMFILNFE 130
           AVIMFILNFE
Sbjct: 121 AVIMFILNFE 130



 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 73/246 (29%), Positives = 98/246 (39%), Gaps = 63/246 (25%)

Query: 670  SSPRQAPGSQDHQGFFLSD--NQSDAAPPLS-----ISDASGLWPEL----LQEMPPRHS 718
            SSPR  PG        + D    SD   PLS     +S+    W +      QE+P   +
Sbjct: 959  SSPRP-PGEPPGGEPLMEDCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPA 1017

Query: 719  PQS-----PQEDPDCWPL-KLGSRLEQLQAQMNRLESRVSSDLSRILQLLQKPMPQGHAS 772
            P       P   P   P   + SRL+ LQ Q+NRLE+R+S+D++ +LQLLQ+ M      
Sbjct: 1018 PTPSLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQM------ 1071

Query: 773  YILEAPASNDLALVPIASETTSPGPRLPQGFLPPAQTPSYGDLDDCSPKHRNSSPRMPHL 832
              L  PA +       A  T  PGP      LP +  P+   LD  S   +         
Sbjct: 1072 -TLVPPAYS-------AVTTPGPGPTSTSPLLPVSPLPTL-TLDSLSQVSQ--------- 1113

Query: 833  AVATDKTLAPSSEQEQPEGLWPPLASPLHPLEVQGLICGPCFSSLPEHLGSVPKQLDFQR 892
                 + L P + +   EG       P   L            SLP  LG++  Q    R
Sbjct: 1114 -FMACEELPPGAPELPQEG-------PTRRL------------SLPGQLGALTSQ-PLHR 1152

Query: 893  HGSDPG 898
            HGSDPG
Sbjct: 1153 HGSDPG 1158


>gi|27886653 potassium voltage-gated channel, subfamily H, member 7
           isoform 1 [Homo sapiens]
          Length = 1196

 Score =  786 bits (2030), Expect = 0.0
 Identities = 402/542 (74%), Positives = 441/542 (81%), Gaps = 53/542 (9%)

Query: 174 KYRTISQIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADV 233
           KY TI++IPQ TLNF E   EK  SS  +  + I   KV +RT NVTEKVTQVLSLGADV
Sbjct: 325 KYSTINKIPQLTLNFSEVKTEKKNSSPPSSDKTIIAPKVKDRTHNVTEKVTQVLSLGADV 384

Query: 234 LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGAC 293
           LPEYKLQ PRI+++TILHYSPFKAVWDWLILLLVIYTA+FTPYSAAFLL+D++E +R  C
Sbjct: 385 LPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRREC 444

Query: 294 SYTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAA 353
            Y+CSPL VVDLIVDIMF++DI+INFRTTYVN N+EVVS P +IA+HYFKGWFLIDMVAA
Sbjct: 445 GYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFKGWFLIDMVAA 504

Query: 354 IPFDLLIFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAH 413
           IPFDLLIF +GSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVL LLMC FALIAH
Sbjct: 505 IPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFALIAH 564

Query: 414 ----------------------WLACI-------------------------------CS 420
                                 WL  +                                S
Sbjct: 565 WLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSS 624

Query: 421 LTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVK 480
           LTSVGFGNVSPNTNSEK+FSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYH QMLRVK
Sbjct: 625 LTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVK 684

Query: 481 EFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCP 540
           EFIRFHQIPNPLRQRLEEYFQHAW+YTNGIDMN VLKGFPECLQADICLHL++ LLQ+C 
Sbjct: 685 EFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCK 744

Query: 541 AFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGK 600
           AF GA KGCLRALA+KFKTTHAPPGDTLVH GDVL+ LYF+SRGSIEIL+DD+VVAILGK
Sbjct: 745 AFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDDIVVAILGK 804

Query: 601 NDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFN 660
           NDIFGE V L+A+PGKS+ADVRALTYCDLHKIQR DLLEVLDMYP F++ F + LE+TFN
Sbjct: 805 NDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQREDLLEVLDMYPEFSDHFLTNLELTFN 864

Query: 661 LR 662
           LR
Sbjct: 865 LR 866



 Score =  194 bits (492), Expect = 4e-49
 Identities = 85/130 (65%), Positives = 111/130 (85%)

Query: 1   MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVM 60
           MPVRRGHVAPQNT+L TIIRKFEGQ++KF+IANA+++NCAIIYCNDGFCE+ G+SR +VM
Sbjct: 1   MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVM 60

Query: 61  QQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDG 120
           Q+PCTCDFL GP T    ++++AQALLG+EE KV++ YY K+ S+F C   ++PVKN++G
Sbjct: 61  QKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEG 120

Query: 121 AVIMFILNFE 130
             +MFI+NFE
Sbjct: 121 VAMMFIINFE 130


>gi|26051273 voltage-gated potassium channel, subfamily H, member 2
           isoform c [Homo sapiens]
          Length = 819

 Score =  759 bits (1960), Expect = 0.0
 Identities = 397/543 (73%), Positives = 428/543 (78%), Gaps = 62/543 (11%)

Query: 197 RSSSTTEIEIIAPHKVVERTQNVTEKVTQ-VLSLGADVLPEYKLQAPRIHRWTILHYSPF 255
           ++S T  +   A    V R   ++  V Q VLSLGADVLPEYKLQAPRIHRWTILHYSPF
Sbjct: 7   KASRTGALRPRAQKGRVRRAVRISSLVAQEVLSLGADVLPEYKLQAPRIHRWTILHYSPF 66

Query: 256 KAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGA-CSYTCSPLTVVDLIVDIMFVVD 314
           KAVWDWLILLLVIYTAVFTPYSAAFLL + +E      C Y C PL VVDLIVDIMF+VD
Sbjct: 67  KAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVD 126

Query: 315 IVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLIFRTGSDETTTLIGL 374
           I+INFRTTYVN N+EVVSHP RIAVHYFKGWFLIDMVAAIPFDLLIF +GS+E   LIGL
Sbjct: 127 ILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEE---LIGL 183

Query: 375 LKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACI---------------- 418
           LKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACI                
Sbjct: 184 LKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRI 243

Query: 419 ------------------------------------CSLTSVGFGNVSPNTNSEKVFSIC 442
                                                SLTSVGFGNVSPNTNSEK+FSIC
Sbjct: 244 GWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSIC 303

Query: 443 VMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQH 502
           VMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRV+EFIRFHQIPNPLRQRLEEYFQH
Sbjct: 304 VMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQH 363

Query: 503 AWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKFKTTHA 562
           AWSYTNGIDMNAVLKGFPECLQADICLHL+R+LLQHC  F GA KGCLRALA+KFKTTHA
Sbjct: 364 AWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHA 423

Query: 563 PPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEPVSLHAQPGKSSADVR 622
           PPGDTLVH GD+L+ LYFISRGSIEILR DVVVAILGKNDIFGEP++L+A+PGKS+ DVR
Sbjct: 424 PPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVR 483

Query: 623 ALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFNLRDAAGGLHSSPRQAPGSQDHQ 682
           ALTYCDLHKI R DLLEVLDMYP F++ FWS LE+TFNLRD      +    +PGS + +
Sbjct: 484 ALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDT-----NMIPGSPGSTELE 538

Query: 683 GFF 685
           G F
Sbjct: 539 GGF 541



 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 73/246 (29%), Positives = 98/246 (39%), Gaps = 63/246 (25%)

Query: 670 SSPRQAPGSQDHQGFFLSD--NQSDAAPPLS-----ISDASGLWPEL----LQEMPPRHS 718
           SSPR  PG        + D    SD   PLS     +S+    W +      QE+P   +
Sbjct: 619 SSPRP-PGEPPGGEPLMEDCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPA 677

Query: 719 PQS-----PQEDPDCWPL-KLGSRLEQLQAQMNRLESRVSSDLSRILQLLQKPMPQGHAS 772
           P       P   P   P   + SRL+ LQ Q+NRLE+R+S+D++ +LQLLQ+ M      
Sbjct: 678 PTPSLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQM------ 731

Query: 773 YILEAPASNDLALVPIASETTSPGPRLPQGFLPPAQTPSYGDLDDCSPKHRNSSPRMPHL 832
             L  PA +       A  T  PGP      LP +  P+   LD  S   +         
Sbjct: 732 -TLVPPAYS-------AVTTPGPGPTSTSPLLPVSPLPTL-TLDSLSQVSQ--------- 773

Query: 833 AVATDKTLAPSSEQEQPEGLWPPLASPLHPLEVQGLICGPCFSSLPEHLGSVPKQLDFQR 892
                + L P + +   EG       P   L            SLP  LG++  Q    R
Sbjct: 774 -FMACEELPPGAPELPQEG-------PTRRL------------SLPGQLGALTSQ-PLHR 812

Query: 893 HGSDPG 898
           HGSDPG
Sbjct: 813 HGSDPG 818


>gi|26051271 voltage-gated potassium channel, subfamily H, member 2
           isoform b [Homo sapiens]
          Length = 888

 Score =  704 bits (1816), Expect = 0.0
 Identities = 367/479 (76%), Positives = 389/479 (81%), Gaps = 57/479 (11%)

Query: 174 KYRTISQIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADV 233
           +YRTIS+IPQ TLNFV+   +   +S T++ EIIAP K+ ERT NVTEKVTQVLSLGADV
Sbjct: 326 RYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAP-KIKERTHNVTEKVTQVLSLGADV 384

Query: 234 LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGA- 292
           LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLL + +E      
Sbjct: 385 LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATE 444

Query: 293 CSYTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVA 352
           C Y C PL VVDLIVDIMF+VDI+INFRTTYVN N+EVVSHP RIAVHYFKGWFLIDMVA
Sbjct: 445 CGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVA 504

Query: 353 AIPFDLLIFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIA 412
           AIPFDLLIF +GS+E   LIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIA
Sbjct: 505 AIPFDLLIFGSGSEE---LIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIA 561

Query: 413 HWLACI----------------------------------------------------CS 420
           HWLACI                                                     S
Sbjct: 562 HWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSS 621

Query: 421 LTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVK 480
           LTSVGFGNVSPNTNSEK+FSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRV+
Sbjct: 622 LTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVR 681

Query: 481 EFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCP 540
           EFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHL+R+LLQHC 
Sbjct: 682 EFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCK 741

Query: 541 AFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILG 599
            F GA KGCLRALA+KFKTTHAPPGDTLVH GD+L+ LYFISRGSIEILR DVVVAILG
Sbjct: 742 PFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILG 800



 Score =  224 bits (570), Expect = 4e-58
 Identities = 106/130 (81%), Positives = 117/130 (90%)

Query: 1   MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVM 60
           MPVRRGHVAPQNT+LDTIIRKFEGQSRKF+IANA++ENCA+IYCNDGFCEL GYSR EVM
Sbjct: 1   MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVM 60

Query: 61  QQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDG 120
           Q+PCTCDFL GP T   A +++AQALLGAEE KV+I +YRKD S F CLVDVVPVKNEDG
Sbjct: 61  QRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDG 120

Query: 121 AVIMFILNFE 130
           AVIMFILNFE
Sbjct: 121 AVIMFILNFE 130


>gi|27886665 potassium voltage-gated channel, subfamily H, member 7
           isoform 2 [Homo sapiens]
          Length = 732

 Score =  479 bits (1233), Expect = e-135
 Identities = 260/395 (65%), Positives = 289/395 (73%), Gaps = 53/395 (13%)

Query: 174 KYRTISQIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADV 233
           KY TI++IPQ TLNF E   EK  SS  +  + I   KV +RT NVTEKVTQVLSLGADV
Sbjct: 318 KYSTINKIPQLTLNFSEVKTEKKNSSPPSSDKTIIAPKVKDRTHNVTEKVTQVLSLGADV 377

Query: 234 LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGAC 293
           LPEYKLQ PRI+++TILHYSPFKAVWDWLILLLVIYTA+FTPYSAAFLL+D++E +R  C
Sbjct: 378 LPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRREC 437

Query: 294 SYTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAA 353
            Y+CSPL VVDLIVDIMF++DI+INFRTTYVN N+EVVS P +IA+HYFKGWFLIDMVAA
Sbjct: 438 GYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFKGWFLIDMVAA 497

Query: 354 IPFDLLIFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAH 413
           IPFDLLIF +GSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVL LLMC FALIAH
Sbjct: 498 IPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFALIAH 557

Query: 414 WLACICS----------------LTSVG--FGNVSPNTNSEKVFSICVMLIGSLMYASI- 454
           WLACI                  L S+G   G    +++S    SI    + +L +    
Sbjct: 558 WLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSS 617

Query: 455 -----FGNV-----------------------------SAIIQRLYSGTARYHTQMLRVK 480
                FGNV                             SAIIQRLYSGTARYH QMLRVK
Sbjct: 618 LTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVK 677

Query: 481 EFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAV 515
           EFIRFHQIPNPLRQRLEEYFQHAW+YTNGIDMN V
Sbjct: 678 EFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMV 712



 Score =  194 bits (492), Expect = 4e-49
 Identities = 85/130 (65%), Positives = 111/130 (85%)

Query: 1   MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVM 60
           MPVRRGHVAPQNT+L TIIRKFEGQ++KF+IANA+++NCAIIYCNDGFCE+ G+SR +VM
Sbjct: 1   MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVM 60

Query: 61  QQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDG 120
           Q+PCTCDFL GP T    ++++AQALLG+EE KV++ YY K+ S+F C   ++PVKN++G
Sbjct: 61  QKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEG 120

Query: 121 AVIMFILNFE 130
             +MFI+NFE
Sbjct: 121 VAMMFIINFE 130


>gi|27886667 potassium voltage-gated channel, subfamily H, member 8
           [Homo sapiens]
          Length = 1107

 Score =  476 bits (1225), Expect = e-134
 Identities = 275/722 (38%), Positives = 407/722 (56%), Gaps = 106/722 (14%)

Query: 1   MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQM-ENCAIIYCNDGFCELFGYSRVEV 59
           MPV +G +APQNT+LDTI  +F+G    F++ANAQ+ +   I+YC+DGFCEL G++R EV
Sbjct: 1   MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEV 60

Query: 60  MQQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNED 119
           MQ+ C+C FL G  T    + ++ ++L    E K +I++Y+K+ S F CL+D+VP+KNE 
Sbjct: 61  MQKSCSCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEK 120

Query: 120 GAVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTIS 179
           G V++F+ +F+D+     K +     +  +                     GR +  T  
Sbjct: 121 GDVVLFLASFKDITDTKVKITPEDKKEDKVK--------------------GRSRAGT-- 158

Query: 180 QIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKL 239
                       + +  R  S   +  I+ H  ++R +    K+   + +     PEYK+
Sbjct: 159 ------------HFDSARRRSRAVLYHISGH--LQRREKNKLKINNNVFVDKPAFPEYKV 204

Query: 240 QAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSP 299
              +  ++ +LH+S FKA WDWLILL   Y AV  PY+  F+ +D   + R         
Sbjct: 205 SDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGNDDLSTTRST------- 257

Query: 300 LTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLL 359
            TV D+ V+I+F++DI++NFRTTYV+ + +V+   R I +HY   WF+ID++AA+PFDLL
Sbjct: 258 -TVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVTTWFIIDLIAALPFDLL 316

Query: 360 IFRTGSDETTTLIGLLKTARL---LRLVR------------------------------- 385
                +    +L+ LLKT RL   LRL++                               
Sbjct: 317 Y--AFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLTLLMSMFALLAHWMACIW 374

Query: 386 -VARKLDRYSE---------------------YGAAVLFLLMCTFALIAHWLACICSLTS 423
            V  K++R                        YG   L       A IA     + SLTS
Sbjct: 375 YVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYIAALYFTLSSLTS 434

Query: 424 VGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFI 483
           VGFGNVS NT++EK+FSIC MLIG+LM+A +FGNV+AIIQR+YS  + YHT+   +K+FI
Sbjct: 435 VGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFI 494

Query: 484 RFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFS 543
           R H +P  L+QR+ EYFQ  WS  NGID N +LK FP+ L++DI +HL++ +LQ    F 
Sbjct: 495 RVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEILQ-LSLFE 553

Query: 544 GAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDI 603
            A +GCLR+L++  KT+   PG+ L+  GD L  +YF+  GS+E+L+D +V+AILGK D+
Sbjct: 554 CASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMVLAILGKGDL 613

Query: 604 FGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKL--EVTFNL 661
            G  +S+  Q  K++ADV+ALTYCDL  I    L EVLD+YP +A  F   +  ++T+NL
Sbjct: 614 IGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPEYAHKFVEDIQHDLTYNL 673

Query: 662 RD 663
           R+
Sbjct: 674 RE 675


>gi|6912446 potassium voltage-gated channel, subfamily H, member 4
           [Homo sapiens]
          Length = 1017

 Score =  469 bits (1207), Expect = e-132
 Identities = 338/952 (35%), Positives = 476/952 (50%), Gaps = 153/952 (16%)

Query: 1   MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQ-MENCAIIYCNDGFCELFGYSRVEV 59
           MPV +G +APQNT+LDTI  +F+G    FL+ANAQ      I+YC+DGFCEL GY R EV
Sbjct: 1   MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEV 60

Query: 60  MQQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNED 119
           MQ+ C+C FL GP T   A+ RL +AL G +E + +I +YRKD S+F CL+D++P+KNE 
Sbjct: 61  MQKTCSCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEM 120

Query: 120 GAVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTIS 179
           G V++F+ +F+D+ Q                          G PG  GP  GRG     +
Sbjct: 121 GEVVLFLFSFKDITQ-------------------------SGSPG-LGPQGGRGDSNHEN 154

Query: 180 QIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKL 239
            + +       +     R  S T +  +  H    R Q   +    V      V PEYK+
Sbjct: 155 SLGR---RGATWKFRSARRRSRTVLHRLTGH-FGRRGQGGMKANNNVFEPKPSV-PEYKV 209

Query: 240 QAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSP 299
            +    R  +LHYS  KA+WD LILL   Y AV  PY+  F  S  D++       T   
Sbjct: 210 ASVGGSRCLLLHYSVSKAIWDGLILLATFYVAVTVPYNVCF--SGDDDT-----PITSRH 262

Query: 300 LTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLL 359
             V D+ V+++F++DI++NFRTTYV+ + +V+S PR I +HY   WF ID++AA+PFDLL
Sbjct: 263 TLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSIGLHYLATWFFIDLIAALPFDLL 322

Query: 360 -IFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACI 418
            IF       T+L+ LLKT RLLRL+R+ +KL+RYS+  A VL LLM  FAL+AHW+ACI
Sbjct: 323 YIFNI---TVTSLVHLLKTVRLLRLLRLLQKLERYSQCSAVVLTLLMSVFALLAHWMACI 379

Query: 419 C-------------SLTSVGF--------------GNVSPNTNSEKVFSICVMLIGSLMY 451
                          L  +G+              G+V   +      +     + SL  
Sbjct: 380 WYVIGRREMEANDPLLWDIGWLHELGKRLEVPYVNGSVGGPSRRSAYIAALYFTLSSLTS 439

Query: 452 ASIFGNV-----------------------------SAIIQRLYSGTARYHTQMLRVKEF 482
              FGNV                             +AIIQR+YS  + YH++M  +K+F
Sbjct: 440 VG-FGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDF 498

Query: 483 IRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAF 542
           IR H++P PL+QR+ EYFQ  W+  +GID N +L+ FP+ L+ADI +HL+R +LQ  P F
Sbjct: 499 IRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREILQ-LPLF 557

Query: 543 SGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKND 602
             A +GCLRAL++  KT+   PG+ L+  GD L   Y++  GS+E+LRD++V+AILGK D
Sbjct: 558 GAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMVLAILGKGD 617

Query: 603 IFGEPV-------SLHAQPG---KSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFW 652
           + G  +        L A P    K+SADV+ALTYC L ++    L EVL +YP +  +F 
Sbjct: 618 LIGADIPEPGQEPGLGADPNFVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPEYGAAFR 677

Query: 653 SKL--EVTFNLR---DAAG--GLHSSPRQAPGSQDHQGFFLSDNQSDAAPPLSISDASGL 705
           + L  ++TFNLR   D +G      SPR +    +  G     + SD   P      SG 
Sbjct: 678 AGLPRDLTFNLRQGSDTSGLSRFSRSPRLSQPRSESLG-----SSSDKTLPSITEAESGA 732

Query: 706 WPELLQEMPPRHSPQSPQEDPDCWPLK-LGSRLEQLQAQMNRLESRVSSDLSRILQLLQK 764
            P       PR  P+ P   P+  P +  GS +  L  ++    + VSS  S    L   
Sbjct: 733 EP----GGGPR--PRRPLLLPNLSPARPRGSLVSLLGEELPPFSALVSSP-SLSPSLSPA 785

Query: 765 PMPQGHASYILEAPASNDLALVPIASETTSPGPRLPQGFLPPAQTPSYGDLDDCSPK--- 821
              QGH++              P      S   + PQ  +PP  T  +G   D SP+   
Sbjct: 786 LAGQGHSA-------------SPHGPPRCSAAWKPPQLLIPPLGT--FGP-PDLSPRIVD 829

Query: 822 ---HRNSSPRMPHLAVATDKTLAPSSEQEQPEGLWPPLASPLHPLEVQGLIC 870
                 S+   P    +    L     Q  P G  P         EV+  +C
Sbjct: 830 GIEDSGSTAEAPSFRFSRRPELPRPRSQAPPTGTRPSPELASEAEEVKEKVC 881


>gi|22024390 potassium voltage-gated channel, subfamily H, member 5
           isoform 1 [Homo sapiens]
          Length = 988

 Score =  456 bits (1174), Expect = e-128
 Identities = 259/722 (35%), Positives = 385/722 (53%), Gaps = 118/722 (16%)

Query: 4   RRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVMQQP 63
           +RG VAPQNT+L+ I+R+    S  FL+ NAQ+ +  ++Y NDGFC+L GY R +VMQ+ 
Sbjct: 5   KRGLVAPQNTFLENIVRRSSESS--FLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKS 62

Query: 64  CTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDGAVI 123
            TC F+ G  T    + ++ Q     E    ++L Y+K+ +     + + P++NE   V+
Sbjct: 63  STCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVV 122

Query: 124 MFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQIPQ 183
           +F+  F+D+          S                                        
Sbjct: 123 LFLCTFKDITLFKQPIEDDS---------------------------------------- 142

Query: 184 FTLNFVEF-NLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKLQAP 242
            T  + +F  L +  ++S + ++ + P    E     + ++ +VL LG+D+LP+YK +AP
Sbjct: 143 -TKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKHS-RLAEVLQLGSDILPQYKQEAP 200

Query: 243 RIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPLTV 302
           +     ILHY  FK  WDW+IL+L  YTA+  PY+ +F     + +             V
Sbjct: 201 KTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIA-----------WLV 249

Query: 303 VDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLL-IF 361
           +D +VD++F+VDIV+NF TT+V    EV+S P+ I ++Y K WF+ID+++ +P+D++  F
Sbjct: 250 LDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAF 309

Query: 362 RTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACICSL 421
               +  ++L   LK  RLLRL RVARKLD Y EYGAAVL LL+C F L+AHWLACI   
Sbjct: 310 ENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYS 369

Query: 422 ----------------------------------TSVGFGNVSPNTNSEKVFSI------ 441
                                             TS G     P+ +S  V S+      
Sbjct: 370 IGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTS 429

Query: 442 ---------------------CVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVK 480
                                 +M++GSL+YA+IFGNV+ I Q++Y+ T RYH  +  V+
Sbjct: 430 LTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVR 489

Query: 481 EFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCP 540
           +F++ +Q+P  L +R+ +Y    WS + GID   VL   P+ ++ADIC+HL+R +    P
Sbjct: 490 DFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHP 549

Query: 541 AFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGK 600
           AF  A  GCLRALAV+F+T H  PGD + H G+ +  L F+  GS+E+++DD VVAILGK
Sbjct: 550 AFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGK 609

Query: 601 NDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFN 660
            D+FG+          + A+VRALTYCDLH I+R  LL+VLD Y AFA SF   L +T N
Sbjct: 610 GDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCN 669

Query: 661 LR 662
           LR
Sbjct: 670 LR 671


>gi|4504831 potassium voltage-gated channel, subfamily H, member 1
           isoform 2 [Homo sapiens]
          Length = 962

 Score =  426 bits (1094), Expect = e-119
 Identities = 255/724 (35%), Positives = 385/724 (53%), Gaps = 120/724 (16%)

Query: 4   RRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVMQQP 63
           RRG VAPQNT+L+ I+R+       F++ NAQ+ +  I+Y NDGFC+L GY R EVMQ+ 
Sbjct: 7   RRGLVAPQNTFLENIVRR--SNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKS 64

Query: 64  CTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDGAVI 123
            TC F+ G  T    + ++ Q     E    +IL Y+K+ +     V + P++NE   V+
Sbjct: 65  STCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVV 124

Query: 124 MFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQIPQ 183
           +F+  F D+          S                           G GK+        
Sbjct: 125 LFLCTFSDITAFKQPIEDDSCK-------------------------GWGKFA------- 152

Query: 184 FTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTE--KVTQVLSLGADVLPEYKLQA 241
                    L +  +SS   ++ +AP   V++ +NV +  ++ +VL LG+D+LP+YK +A
Sbjct: 153 --------RLTRALTSSRGVLQQLAPS--VQKGENVHKHSRLAEVLQLGSDILPQYKQEA 202

Query: 242 PRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPLT 301
           P+     ILHY  FK  WDW+IL+L  YTA+  PY+ +F      ++R+   ++      
Sbjct: 203 PKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSF------KTRQNNVAW-----L 251

Query: 302 VVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLL-I 360
           VVD IVD++F+VDIV+NF TT+V    EV+S P+ I ++Y K WF+ID+++ +P+D++  
Sbjct: 252 VVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINA 311

Query: 361 FRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACI-- 418
           F    +  ++L   LK  RLLRL RVARKLD Y EYGAAVL LL+C F L AHW+ACI  
Sbjct: 312 FENVDEGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWY 371

Query: 419 -------------------------------CSLTSVGFGNVSPNTNSEKVFSICVMLIG 447
                                                G G      +   V+   +    
Sbjct: 372 SIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTM 431

Query: 448 SLMYASIFGNV--SAIIQRLYS------GTARYHT--------------------QMLR- 478
           + + +  FGN+  S  I+++++      G+  Y T                    +ML  
Sbjct: 432 TSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNS 491

Query: 479 VKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQH 538
           V++F++ +Q+P  L +R+ +Y    WS + GID   VL+  P+ ++ADIC+HL+R + + 
Sbjct: 492 VRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKE 551

Query: 539 CPAFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAIL 598
            PAF  A  GCLRALA++F+T H  PGD + H G+ + +L F+  GS+E+++DD VVAIL
Sbjct: 552 HPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAIL 611

Query: 599 GKNDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVT 658
           GK D+FG+     A   +S A+VRALTYCDLH I+R  L +VL+ Y AF+ SF   L +T
Sbjct: 612 GKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILT 671

Query: 659 FNLR 662
           +NLR
Sbjct: 672 YNLR 675


>gi|27437001 potassium voltage-gated channel, subfamily H, member 1
           isoform 1 [Homo sapiens]
          Length = 989

 Score =  416 bits (1068), Expect = e-116
 Identities = 256/751 (34%), Positives = 385/751 (51%), Gaps = 147/751 (19%)

Query: 4   RRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVMQQP 63
           RRG VAPQNT+L+ I+R+       F++ NAQ+ +  I+Y NDGFC+L GY R EVMQ+ 
Sbjct: 7   RRGLVAPQNTFLENIVRR--SNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKS 64

Query: 64  CTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDGAVI 123
            TC F+ G  T    + ++ Q     E    +IL Y+K+ +     V + P++NE   V+
Sbjct: 65  STCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVV 124

Query: 124 MFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQIPQ 183
           +F+  F D+          S                           G GK+        
Sbjct: 125 LFLCTFSDITAFKQPIEDDSCK-------------------------GWGKFA------- 152

Query: 184 FTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTE--KVTQVLSLGADVLPEYKLQA 241
                    L +  +SS   ++ +AP   V++ +NV +  ++ +VL LG+D+LP+YK +A
Sbjct: 153 --------RLTRALTSSRGVLQQLAPS--VQKGENVHKHSRLAEVLQLGSDILPQYKQEA 202

Query: 242 PRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPLT 301
           P+     ILHY  FK  WDW+IL+L  YTA+  PY+ +F      ++R+   ++      
Sbjct: 203 PKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSF------KTRQNNVAW-----L 251

Query: 302 VVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLIF 361
           VVD IVD++F+VDIV+NF TT+V    EV+S P+ I ++Y K WF+ID+++ +P+D++  
Sbjct: 252 VVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINA 311

Query: 362 RTGSDETTTLIG----------------------------LLKTARLLRLVRVARKLDRY 393
               DE +  +G                             LK  RLLRL RVARKLD Y
Sbjct: 312 FENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHY 371

Query: 394 SEYGAAVLFLLMCTFALIAHWLACI---------------------------------CS 420
            EYGAAVL LL+C F L AHW+ACI                                   
Sbjct: 372 IEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQ 431

Query: 421 LTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNV--SAIIQRLYS------GTARY 472
               G G      +   V+   +    + + +  FGN+  S  I+++++      G+  Y
Sbjct: 432 FNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLY 491

Query: 473 HT--------------------QMLR-VKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGID 511
            T                    +ML  V++F++ +Q+P  L +R+ +Y    WS + GID
Sbjct: 492 ATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGID 551

Query: 512 MNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKFKTTHAPPGDTLVHL 571
              VL+  P+ ++ADIC+HL+R + +  PAF  A  GCLRALA++F+T H  PGD + H 
Sbjct: 552 TEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHA 611

Query: 572 GDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEPVSLHAQPGKSSADVRALTYCDLHK 631
           G+ + +L F+  GS+E+++DD VVAILGK D+FG+     A   +S A+VRALTYCDLH 
Sbjct: 612 GESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHV 671

Query: 632 IQRADLLEVLDMYPAFAESFWSKLEVTFNLR 662
           I+R  L +VL+ Y AF+ SF   L +T+NLR
Sbjct: 672 IKRDALQKVLEFYTAFSHSFSRNLILTYNLR 702


>gi|27886648 potassium voltage-gated channel, subfamily H, member 5
           isoform 2 [Homo sapiens]
          Length = 624

 Score =  400 bits (1028), Expect = e-111
 Identities = 231/666 (34%), Positives = 345/666 (51%), Gaps = 116/666 (17%)

Query: 60  MQQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNED 119
           MQ+  TC F+ G  T    + ++ Q     E    ++L Y+K+ +     + + P++NE 
Sbjct: 1   MQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEH 60

Query: 120 GAVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTIS 179
             V++F+  F+D+          S                                    
Sbjct: 61  EKVVLFLCTFKDITLFKQPIEDDS------------------------------------ 84

Query: 180 QIPQFTLNFVEF-NLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYK 238
                T  + +F  L +  ++S + ++ + P    E     + ++ +VL LG+D+LP+YK
Sbjct: 85  -----TKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKHS-RLAEVLQLGSDILPQYK 138

Query: 239 LQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCS 298
            +AP+     ILHY  FK  WDW+IL+L  YTA+  PY+ +F     + +          
Sbjct: 139 QEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIA---------- 188

Query: 299 PLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDL 358
              V+D +VD++F+VDIV+NF TT+V    EV+S P+ I ++Y K WF+ID+++ +P+D+
Sbjct: 189 -WLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDI 247

Query: 359 L-IFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLAC 417
           +  F    +  ++L   LK  RLLRL RVARKLD Y EYGAAVL LL+C F L+AHWLAC
Sbjct: 248 INAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLAC 307

Query: 418 ICSL----------------------------------TSVGFGNVSPNTNSEKVFSI-- 441
           I                                     TS G     P+ +S  V S+  
Sbjct: 308 IWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYF 367

Query: 442 -------------------------CVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQM 476
                                     +M++GSL+YA+IFGNV+ I Q++Y+ T RYH  +
Sbjct: 368 TMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEML 427

Query: 477 LRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALL 536
             V++F++ +Q+P  L +R+ +Y    WS + GID   VL   P+ ++ADIC+HL+R + 
Sbjct: 428 NNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVF 487

Query: 537 QHCPAFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVA 596
              PAF  A  GCLRALAV+F+T H  PGD + H G+ +  L F+  GS+E+++DD VVA
Sbjct: 488 NEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVA 547

Query: 597 ILGKNDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLE 656
           ILGK D+FG+          + A+VRALTYCDLH I+R  LL+VLD Y AFA SF   L 
Sbjct: 548 ILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLT 607

Query: 657 VTFNLR 662
           +T NLR
Sbjct: 608 LTCNLR 613


>gi|27886646 potassium voltage-gated channel, subfamily H, member 5
           isoform 3 [Homo sapiens]
          Length = 611

 Score =  396 bits (1018), Expect = e-110
 Identities = 225/658 (34%), Positives = 344/658 (52%), Gaps = 118/658 (17%)

Query: 4   RRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVMQQP 63
           +RG VAPQNT+L+ I+R+    S  FL+ NAQ+ +  ++Y NDGFC+L GY R +VMQ+ 
Sbjct: 5   KRGLVAPQNTFLENIVRRSSESS--FLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKS 62

Query: 64  CTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDGAVI 123
            TC F+ G  T    + ++ Q     E    ++L Y+K+ +     + + P++NE   V+
Sbjct: 63  STCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVV 122

Query: 124 MFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQIPQ 183
           +F+  F+D+          S                                        
Sbjct: 123 LFLCTFKDITLFKQPIEDDS---------------------------------------- 142

Query: 184 FTLNFVEF-NLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKLQAP 242
            T  + +F  L +  ++S + ++ + P    E     + ++ +VL LG+D+LP+YK +AP
Sbjct: 143 -TKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKHS-RLAEVLQLGSDILPQYKQEAP 200

Query: 243 RIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPLTV 302
           +     ILHY  FK  WDW+IL+L  YTA+  PY+ +F     + +             V
Sbjct: 201 KTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIA-----------WLV 249

Query: 303 VDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLL-IF 361
           +D +VD++F+VDIV+NF TT+V    EV+S P+ I ++Y K WF+ID+++ +P+D++  F
Sbjct: 250 LDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAF 309

Query: 362 RTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACICSL 421
               +  ++L   LK  RLLRL RVARKLD Y EYGAAVL LL+C F L+AHWLACI   
Sbjct: 310 ENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYS 369

Query: 422 ----------------------------------TSVGFGNVSPNTNSEKVFSI------ 441
                                             TS G     P+ +S  V S+      
Sbjct: 370 IGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTS 429

Query: 442 ---------------------CVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVK 480
                                 +M++GSL+YA+IFGNV+ I Q++Y+ T RYH  +  V+
Sbjct: 430 LTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVR 489

Query: 481 EFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCP 540
           +F++ +Q+P  L +R+ +Y    WS + GID   VL   P+ ++ADIC+HL+R +    P
Sbjct: 490 DFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHP 549

Query: 541 AFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAIL 598
           AF  A  GCLRALAV+F+T H  PGD + H G+ +  L F+  GS+E+++DD VVAIL
Sbjct: 550 AFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAIL 607


>gi|38569493 potassium voltage-gated channel, subfamily H
           (eag-related), member 3 [Homo sapiens]
          Length = 1083

 Score =  275 bits (702), Expect = 2e-73
 Identities = 161/426 (37%), Positives = 241/426 (56%), Gaps = 57/426 (13%)

Query: 1   MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENC-AIIYCNDGFCELFGYSRVEV 59
           MP  RG +APQNT+LDTI  +F+G    F++ NAQ+     ++YC+DGFC+L G+SR EV
Sbjct: 1   MPAMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEV 60

Query: 60  MQQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNED 119
           MQ+ C C FL GP+T      ++ +AL   +E K +++ YRK    F CL+DV+P+KNE 
Sbjct: 61  MQRGCACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEK 120

Query: 120 GAVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPG----PGTGRGKY 175
           G V +F+++ +D+++   +                         GGP      G GR +Y
Sbjct: 121 GEVALFLVSHKDISETKNR-------------------------GGPDRWKETGGGRRRY 155

Query: 176 -RTISQIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVL 234
            R  S+          FN  + RS +   +  ++ H  +++      K+ + +      L
Sbjct: 156 GRARSK---------GFNANRRRSRAV--LYHLSGH--LQKQPKGKHKLNKGVFGEKPNL 202

Query: 235 PEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACS 294
           PEYK+ A R   + +LH    +A WD  ILL  +Y AV  PYS     + +  + RG   
Sbjct: 203 PEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAVTVPYSVCVSTAREPSAARG--- 259

Query: 295 YTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAI 354
               P +V DL V+++F++DIV+NFRTT+V+ + +VV  P+ I +HY   WFL+D++AA+
Sbjct: 260 ----PPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYVTTWFLLDVIAAL 315

Query: 355 PFDLLIFRTGSDETTTLIG--LLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIA 412
           PFDLL     + +     G  LLKT RLLRL+R+  +LDRYS+Y A VL LLM  FAL+A
Sbjct: 316 PFDLL----HAFKVNVYFGAHLLKTVRLLRLLRLLPRLDRYSQYSAVVLTLLMAVFALLA 371

Query: 413 HWLACI 418
           HW+AC+
Sbjct: 372 HWVACV 377



 Score =  247 bits (630), Expect = 4e-65
 Identities = 136/322 (42%), Positives = 192/322 (59%), Gaps = 16/322 (4%)

Query: 409 ALIAHWLACICSLTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSG 468
           A I      + SLTSVGFGNVS NT++EK+FSIC MLIG+LM+A +FGNV+AIIQR+Y+ 
Sbjct: 451 AYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNVTAIIQRMYAR 510

Query: 469 TARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADIC 528
              YH++   ++++IR H+IP PL+QR+ EYFQ  W+  NGID   +L+  P+ L+ADI 
Sbjct: 511 RFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQSLPDELRADIA 570

Query: 529 LHLHRALLQHCPAFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEI 588
           +HLH+ +LQ  P F  A +GCLRAL++  +     PG+ L+H GD L  LYF+  GS+E+
Sbjct: 571 MHLHKEVLQ-LPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQALYFVCSGSMEV 629

Query: 589 LRDDVVVAILGKNDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFA 648
           L+   V+AILGK D+ G  +    Q  K++ADV+ LTYC L  +Q A L + L +YP FA
Sbjct: 630 LKGGTVLAILGKGDLIGCELPRREQVVKANADVKGLTYCVLQCLQLAGLHDSLALYPEFA 689

Query: 649 ESFWSKL--EVTFNLRDAAGGLHSSPRQAPGSQDHQGFFLSDNQSDAAPPLSISDASGLW 706
             F   L  E+++NL  A GG       +    +     L + ++D     ++S A    
Sbjct: 690 PRFSRGLRGELSYNL-GAGGGSAEVDTSSLSGDNTLMSTLEEKETDGEQGPTVSPA---- 744

Query: 707 PELLQEMPPRHSPQSPQEDPDC 728
                   P   P SP   P C
Sbjct: 745 --------PADEPSSPLLSPGC 758


>gi|4885407 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 4 [Homo sapiens]
          Length = 1203

 Score =  170 bits (430), Expect = 6e-42
 Identities = 123/465 (26%), Positives = 206/465 (44%), Gaps = 74/465 (15%)

Query: 247 WTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPLTVVDLI 306
           W I  YS F+  WD  +LLL++   +  P    F    +DE+         +P  V +++
Sbjct: 253 WIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFF---KDENT--------TPWIVFNVV 301

Query: 307 VDIMFVVDIVINFRT-TYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFD--LLIFRT 363
            D  F++D+V+NFRT   V  N E++  P+RI + Y K WF++D +++IP D   LI  T
Sbjct: 302 SDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVET 361

Query: 364 GSDET-------------TTLIGLLKTARLLRLVRVARKLDR-----YSEYGAAVLFL-L 404
             D               T ++ LL+  RL RL+R   + +      Y    A V  + L
Sbjct: 362 RIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNL 421

Query: 405 MCTFALIAHWLACICSLTS--------------------------------------VGF 426
           +    L+ HW  C+  L                                        +G+
Sbjct: 422 IGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSYALFKAMSHMLCIGY 481

Query: 427 GNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFH 486
           G  +P   S+   ++  M++G+  YA   G+ +A+IQ L S   +Y  +  +V++++ FH
Sbjct: 482 GRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFH 541

Query: 487 QIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAG 546
           ++P   RQR+ +Y++H +      D  ++L    E L+ +I     R L+   P F+ A 
Sbjct: 542 KLPPDTRQRIHDYYEHRYQ-GKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANAD 600

Query: 547 KGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGE 606
              + ++  K +     PGD ++  G +   +YFI  G + +L        L     FGE
Sbjct: 601 PNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGE 660

Query: 607 PVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESF 651
              L    G+ +A VRA TYC L+ +   +  EVL+ YP    +F
Sbjct: 661 ICLL--TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAF 703


>gi|156071470 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 2 [Homo sapiens]
          Length = 889

 Score =  168 bits (425), Expect = 2e-41
 Identities = 177/727 (24%), Positives = 292/727 (40%), Gaps = 127/727 (17%)

Query: 247 WTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPLTVVDLI 306
           W I  YS F+  WD+ +LL ++   +  P    F    +DE        T +P  V +++
Sbjct: 202 WIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFF---KDE--------TTAPWIVFNVV 250

Query: 307 VDIMFVVDIVINFRTTYV-NTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFD--LLIFRT 363
            D  F++D+V+NFRT  V   N E++  P +I   Y + WF++D V++IP D   LI   
Sbjct: 251 SDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDYIFLIVEK 310

Query: 364 GSDET-------------TTLIGLLKTARLLRLVRVARKLDR--YSEYGAAVLFLLMCTF 408
           G D               T ++ LL+  RL RL+R   + +   +  Y  A   + +C  
Sbjct: 311 GIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICNL 370

Query: 409 A----LIAHWLACICSLTS--------------------------------------VGF 426
                L+ HW  C+  L                                        +G+
Sbjct: 371 ISMMLLLCHWDGCLQFLVPMLQDFPRNCWVSINGMVNHSWSELYSFALFKAMSHMLCIGY 430

Query: 427 GNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFH 486
           G  +P + ++   ++  M++G+  YA   G+ +A+IQ L S   +Y  +  +V++++ FH
Sbjct: 431 GRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFH 490

Query: 487 QIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAG 546
           ++P   RQ++ +Y++H +      D +++L      L+ +I     R L+   P F+ A 
Sbjct: 491 KLPADFRQKIHDYYEHRYQ-GKMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANAD 549

Query: 547 KGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGE 606
              + A+  K K     PGD ++  G +   +YFI  G + +L        L     FGE
Sbjct: 550 PNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGE 609

Query: 607 PVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFNLRDAAG 666
              L    G+ +A VRA TYC L+ +   +  EVL+ YP    +F +   V  +  D  G
Sbjct: 610 ICLL--TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFET---VAIDRLDRIG 664

Query: 667 GLHSSPRQAPGSQDHQGFFLSDNQSDAAPPLSISDASGLWPELLQ--EMPPRHSPQSPQE 724
             +S          + G F  +NQ +A     I +      E++Q  E+  R     P  
Sbjct: 665 KKNSILLHKVQHDLNSGVF--NNQENAI----IQEIVKYDREMVQQAELGQRVGLFPPPP 718

Query: 725 DPDCWPLKLGSRLEQLQAQMNRLESRVSSDLSRILQLLQKPMPQGHASYILEAPASNDLA 784
            P     ++ S +  LQ      ++   S   ++ + L  P+  G    +   P      
Sbjct: 719 PPP----QVTSAIATLQ------QAAAMSFCPQVARPLVGPLALGSPRLVRRPPPGP--- 765

Query: 785 LVPIASETTSPGPRLPQGFLPPA-----QTPSYGDLDDCSPKHRNSSPRMPHLAVATDKT 839
             P A+    P P  P G   PA     +T  YG L    P    + P +P   ++    
Sbjct: 766 -APAAASPGPPPPASPPG--APASPRAPRTSPYGGL----PAAPLAGPALPARRLSRASR 818

Query: 840 LAPSSEQEQPEGLWPPLASPLHPLEVQGLICGPCFSSLPEHLGSVP-----KQLDFQRHG 894
              +S+   P G   P AS             P  SS P  LG  P          +R  
Sbjct: 819 PLSASQPSLPHGAPGPAAS-----------TRPASSSTP-RLGPTPAARAAAPSPDRRDS 866

Query: 895 SDPGFAG 901
           + PG AG
Sbjct: 867 ASPGAAG 873


>gi|116325989 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 1 [Homo sapiens]
          Length = 890

 Score =  165 bits (418), Expect = 2e-40
 Identities = 170/714 (23%), Positives = 290/714 (40%), Gaps = 103/714 (14%)

Query: 247 WTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPLTVVDLI 306
           W I  YS F+  WD ++L++++   V  P    F               T +P  + ++ 
Sbjct: 133 WIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQ-----------TTTPWIIFNVA 181

Query: 307 VDIMFVVDIVINFRTTYVNTND-EVVSHPRRIAVHYFKGWFLIDMVAAIPFD--LLIFRT 363
            D +F++D+++NFRT  VN +  E++  P+ I ++Y K WF++D +++IP D   LI   
Sbjct: 182 SDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEK 241

Query: 364 GSDET-------------TTLIGLLKTARLLRLVRVARKLDR-----YSEYGAAV-LFLL 404
           G D               T ++ LL+  RL RL+R   + +      Y    A V +F L
Sbjct: 242 GMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNL 301

Query: 405 MCTFALIAHWLACICSLTS--------------------------------------VGF 426
           +    L+ HW  C+  L                                        +G+
Sbjct: 302 IGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGY 361

Query: 427 GNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFH 486
           G  +P + S+   ++  M++G+  YA   G+ +A+IQ L S   +Y  +  +V++++ FH
Sbjct: 362 GAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFH 421

Query: 487 QIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAG 546
           ++P  +RQ++ +Y++H +      D   +L    + L+ +I     R L+   P F+ A 
Sbjct: 422 KLPADMRQKIHDYYEHRYQ-GKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANAD 480

Query: 547 KGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGE 606
              + A+  K +     PGD ++  G V   +YFI  G   ++        L     FGE
Sbjct: 481 PNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGE 540

Query: 607 PVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFNLRDAAG 666
              L    G+ +A VRA TYC L+ +   +  EVL+ YP    +F +   V  +  D  G
Sbjct: 541 ICLL--TKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFET---VAIDRLDRIG 595

Query: 667 GLHSSPRQAPGSQDHQGFFLSDNQSDAAPPLSISDASGLWPELLQEMPPRHSPQSPQEDP 726
             +S   Q      + G F ++ +++    +   D      E++Q + P + PQ    + 
Sbjct: 596 KKNSILLQKFQKDLNTGVF-NNQENEILKQIVKHDR-----EMVQAIAPINYPQMTTLNS 649

Query: 727 DCWPLKLGSRLEQLQAQMNRLESRVSSDLSRILQLLQKPMPQ------GHASYILEAPAS 780
                   SR+      +    S   S+L       Q P P        + + +   P  
Sbjct: 650 TSSTTTPTSRMRTQSPPVYTATSLSHSNLHSPSPSTQTPQPSAILSPCSYTTAVCSPPVQ 709

Query: 781 NDLA--LVPIASETTSPGPRLPQGFLPPAQTPSYGDLDDCSPKHRNSSPRMPHLAVATDK 838
           + LA      AS T S    + Q    P Q           P+  +  P+ P    +T K
Sbjct: 710 SPLAARTFHYASPTASQLSLMQQ---QPQQQVQQSQPPQTQPQQPSPQPQTP--GSSTPK 764

Query: 839 TLAPSSEQ-----EQPEGLWPPLAS-PLHPLEVQGLICGPCFSSLPEHLGSVPK 886
                S Q          + P  AS P  P EV  LI  P   ++ E L S+P+
Sbjct: 765 NEVHKSTQALHNTNLTREVRPLSASQPSLPHEVSTLISRP-HPTVGESLASIPQ 817


>gi|38327037 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 3 [Homo sapiens]
          Length = 774

 Score =  162 bits (411), Expect = 1e-39
 Identities = 140/550 (25%), Positives = 229/550 (41%), Gaps = 111/550 (20%)

Query: 165 GPGPGTG-RGKYRTISQIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKV 223
           GP P +G   K R +  + Q T+N  +F+L            +   HK VE  Q      
Sbjct: 35  GPIPKSGPEPKRRHLGTLLQPTVN--KFSLR-----------VFGSHKAVEIEQE----- 76

Query: 224 TQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLS 283
            +V S GA               W I  YS F+  WD ++LLL++   +  P    F   
Sbjct: 77  -RVKSAGA---------------WIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKE 120

Query: 284 DQDESRRGACSYTCSPLTVVDLIVDIMFVVDIVINFRT-TYVNTNDEVVSHPRRIAVHYF 342
           +              P  V +++ D  F++D+V+NFRT   V    E++  PR I   Y 
Sbjct: 121 ENSP-----------PWIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYL 169

Query: 343 KGWFLIDMVAAIPFDLL-------------IFRTGSD----ETTTLIGLLKTARLLRLVR 385
           + WFL+D++++IP D +             +++T         T ++ LL+  RL RL+R
Sbjct: 170 RTWFLVDLISSIPVDYIFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIR 229

Query: 386 VARKLDR-----YSEYGAAV-LFLLMCTFALIAHWLACICSLTS---------------- 423
              + +      Y    A V +F L+    L+ HW  C+  L                  
Sbjct: 230 YIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHM 289

Query: 424 ----------------------VGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAI 461
                                 +G+G  +P    +   ++  M++G+  YA   G+ +A+
Sbjct: 290 VNHSWGRQYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATAL 349

Query: 462 IQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPE 521
           IQ L S   +Y  +  +V++++ FH++P   RQR+ EY++H +      D  ++L    E
Sbjct: 350 IQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQ-GKMFDEESILGELSE 408

Query: 522 CLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFI 581
            L+ +I     R L+ H P F+ A    + A+  K +     PGD +V  G V   +YFI
Sbjct: 409 PLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFI 468

Query: 582 SRGSIEILRDDVVVAILGKNDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVL 641
             G + +L        L     FGE   L    G+ +A VRA TYC L+ +       VL
Sbjct: 469 QHGLLSVLARGARDTRLTDGSYFGEICLL--TRGRRTASVRADTYCRLYSLSVDHFNAVL 526

Query: 642 DMYPAFAESF 651
           + +P    +F
Sbjct: 527 EEFPMMRRAF 536


>gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2
           [Homo sapiens]
          Length = 676

 Score =  143 bits (360), Expect = 8e-34
 Identities = 104/394 (26%), Positives = 183/394 (46%), Gaps = 56/394 (14%)

Query: 302 VVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHY-FKGWFLIDMVAAIPFDLLI 360
           V+D   D+++V+D+++  RT ++     +VS   R+  HY     F +D+++ +P DL  
Sbjct: 187 VLDYSADVLYVLDVLVRARTGFLEQG-LMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 245

Query: 361 FRTGSDETTTLIG-LLKTARLLRLVRVARKLDRYSEY---GAAVLFLLMCTFALIAHWLA 416
            + G++        LLK +RL            Y      G  VL++L     +I HW A
Sbjct: 246 LKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYIL-----IIIHWNA 300

Query: 417 CICSLTS--VGFG-------NVS------------------------------PNTNSEK 437
           CI    S  +GFG       N+S                              P  + E 
Sbjct: 301 CIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEY 360

Query: 438 VFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLE 497
           +F +   L+G L++A+I GNV ++I  + +  A +  ++  +K++++F ++   L  R+ 
Sbjct: 361 LFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVI 420

Query: 498 EYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKF 557
            +F + W+    +D   VLK  P+ L+A+I +++H   L+    F     G L  L +K 
Sbjct: 421 RWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKL 480

Query: 558 KTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVV--AILGKNDIFGEPVSLHAQPG 615
           + T   PGD +   GD+   +Y I+ G + ++ DD V    +L     FGE   L+ +  
Sbjct: 481 RPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGS 540

Query: 616 KS----SADVRALTYCDLHKIQRADLLEVLDMYP 645
           KS    +A++R++ Y DL  + + DL+E L  YP
Sbjct: 541 KSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYP 574


>gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Homo
           sapiens]
          Length = 694

 Score =  143 bits (360), Expect = 8e-34
 Identities = 104/394 (26%), Positives = 183/394 (46%), Gaps = 56/394 (14%)

Query: 302 VVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHY-FKGWFLIDMVAAIPFDLLI 360
           V+D   D+++V+D+++  RT ++     +VS   R+  HY     F +D+++ +P DL  
Sbjct: 205 VLDYSADVLYVLDVLVRARTGFLEQG-LMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 263

Query: 361 FRTGSDETTTLIG-LLKTARLLRLVRVARKLDRYSEY---GAAVLFLLMCTFALIAHWLA 416
            + G++        LLK +RL            Y      G  VL++L     +I HW A
Sbjct: 264 LKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYIL-----IIIHWNA 318

Query: 417 CICSLTS--VGFG-------NVS------------------------------PNTNSEK 437
           CI    S  +GFG       N+S                              P  + E 
Sbjct: 319 CIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEY 378

Query: 438 VFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLE 497
           +F +   L+G L++A+I GNV ++I  + +  A +  ++  +K++++F ++   L  R+ 
Sbjct: 379 LFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVI 438

Query: 498 EYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKF 557
            +F + W+    +D   VLK  P+ L+A+I +++H   L+    F     G L  L +K 
Sbjct: 439 RWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKL 498

Query: 558 KTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVV--AILGKNDIFGEPVSLHAQPG 615
           + T   PGD +   GD+   +Y I+ G + ++ DD V    +L     FGE   L+ +  
Sbjct: 499 RPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGS 558

Query: 616 KS----SADVRALTYCDLHKIQRADLLEVLDMYP 645
           KS    +A++R++ Y DL  + + DL+E L  YP
Sbjct: 559 KSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYP 592


>gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1
           [Homo sapiens]
          Length = 759

 Score =  139 bits (349), Expect = 2e-32
 Identities = 108/433 (24%), Positives = 195/433 (45%), Gaps = 57/433 (13%)

Query: 259 WDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPLTVVDLIVDIMFVVDIVIN 318
           W + I L V+Y        A F     DE +     Y      ++D + DI++++D+ + 
Sbjct: 237 WLFCITLPVMYNWTMVIARACF-----DELQSDYLEYWL----ILDYVSDIVYLIDMFVR 287

Query: 319 FRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLIFRTGSDETTTLIGLLKTA 378
            RT Y+     V    + I  +     F +D+++ IP DLL F+ G +     I L +  
Sbjct: 288 TRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPE--IRLNRLL 345

Query: 379 RLLRLVRVARKLDRYSEYGAAV-LFLLMCTFALIAHWLACICSLTS--VGFGN---VSPN 432
           R  R+    ++ +  + Y     +  L+    +I HW AC+    S  +GFGN   V P+
Sbjct: 346 RFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPD 405

Query: 433 TN----------------------------------SEKVFSICVMLIGSLMYASIFGNV 458
            N                                  SE VF +   LIG L++A+I GN+
Sbjct: 406 INDPEFGRLARKYVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNI 465

Query: 459 SAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKG 518
            ++I  + +  A +  ++  +K+++ F  +   + +R+ ++F + W+    +D   VLK 
Sbjct: 466 GSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKY 525

Query: 519 FPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTL 578
            P+ L+A+I +++H   L+    F+    G L  L +K +     PGD +   GD+   +
Sbjct: 526 LPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREM 585

Query: 579 YFISRGSIEILRDDVVV--AILGKNDIFGEPVSLHAQPGKS----SADVRALTYCDLHKI 632
           Y I  G + ++ DD V    +L     FGE   L+ +  K+    +A+++++ Y DL  +
Sbjct: 586 YIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCL 645

Query: 633 QRADLLEVLDMYP 645
            + DL+E L  YP
Sbjct: 646 SKDDLMEALTEYP 658


>gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [Homo
           sapiens]
          Length = 690

 Score =  139 bits (349), Expect = 2e-32
 Identities = 108/433 (24%), Positives = 195/433 (45%), Gaps = 57/433 (13%)

Query: 259 WDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPLTVVDLIVDIMFVVDIVIN 318
           W + I L V+Y        A F     DE +     Y      ++D + DI++++D+ + 
Sbjct: 168 WLFCITLPVMYNWTMVIARACF-----DELQSDYLEYWL----ILDYVSDIVYLIDMFVR 218

Query: 319 FRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLIFRTGSDETTTLIGLLKTA 378
            RT Y+     V    + I  +     F +D+++ IP DLL F+ G +     I L +  
Sbjct: 219 TRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPE--IRLNRLL 276

Query: 379 RLLRLVRVARKLDRYSEYGAAV-LFLLMCTFALIAHWLACICSLTS--VGFGN---VSPN 432
           R  R+    ++ +  + Y     +  L+    +I HW AC+    S  +GFGN   V P+
Sbjct: 277 RFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPD 336

Query: 433 TN----------------------------------SEKVFSICVMLIGSLMYASIFGNV 458
            N                                  SE VF +   LIG L++A+I GN+
Sbjct: 337 INDPEFGRLARKYVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNI 396

Query: 459 SAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKG 518
            ++I  + +  A +  ++  +K+++ F  +   + +R+ ++F + W+    +D   VLK 
Sbjct: 397 GSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKY 456

Query: 519 FPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTL 578
            P+ L+A+I +++H   L+    F+    G L  L +K +     PGD +   GD+   +
Sbjct: 457 LPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREM 516

Query: 579 YFISRGSIEILRDDVVV--AILGKNDIFGEPVSLHAQPGKS----SADVRALTYCDLHKI 632
           Y I  G + ++ DD V    +L     FGE   L+ +  K+    +A+++++ Y DL  +
Sbjct: 517 YIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCL 576

Query: 633 QRADLLEVLDMYP 645
            + DL+E L  YP
Sbjct: 577 SKDDLMEALTEYP 589


>gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]
          Length = 664

 Score =  126 bits (316), Expect = 1e-28
 Identities = 99/399 (24%), Positives = 177/399 (44%), Gaps = 66/399 (16%)

Query: 302 VVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGW-FLIDMVAAIPFDLLI 360
           V+D + D++++ D+ I  RT ++     +V   +++  +Y     F +D+ + IP DL+ 
Sbjct: 177 VLDYVSDVVYIADLFIRLRTGFLEQG-LLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIY 235

Query: 361 FRTGSDETTTLIGLLKTARLLRLVRVARKLDRYS---------EYGAAVLFLLMCTFALI 411
           F             ++  RLL   R+    DR                VL++L+     I
Sbjct: 236 FAVDIHSPE-----VRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILV-----I 285

Query: 412 AHWLACI--CSLTSVGFG-------NVS------------------------------PN 432
            HW ACI      S+GFG       N++                              P 
Sbjct: 286 IHWNACIYYAISKSIGFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPV 345

Query: 433 TNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPL 492
            + E +F I   LIG L++A+I GNV ++I  + +  A +  ++  VK +++F ++   +
Sbjct: 346 KDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGM 405

Query: 493 RQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRA 552
             ++  +F + W+    +D   +LK  P  L+A+I +++H + L+    F     G L  
Sbjct: 406 EAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVE 465

Query: 553 LAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVV--AILGKNDIFGEPVSL 610
           L +K +     PGD +   GD+   +Y I  G + ++ DD V   A+L     FGE   L
Sbjct: 466 LVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISIL 525

Query: 611 HAQPGK----SSADVRALTYCDLHKIQRADLLEVLDMYP 645
           + +  K     +A++R+L Y DL  + + DL+E +  YP
Sbjct: 526 NIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYP 564


>gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]
          Length = 575

 Score =  121 bits (303), Expect = 3e-27
 Identities = 93/394 (23%), Positives = 174/394 (44%), Gaps = 56/394 (14%)

Query: 302 VVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGW-FLIDMVAAIPFDLLI 360
           V+D   D+++++D+V+ F T ++     VV   R I+  Y + W F +D+ + +P D++ 
Sbjct: 71  VLDYTSDLLYLLDMVVRFHTGFLEQGILVVDKGR-ISSRYVRTWSFFLDLASLMPTDVVY 129

Query: 361 FRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEY----GAAVLFLLMCTFALIAHWLA 416
            R G    T     L+  R LR  R+    DR         A  +  LM    ++ HW +
Sbjct: 130 VRLGPHTPT-----LRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVIHWNS 184

Query: 417 CICSLTS--VGFGNVS-------------------------------------PNTNSEK 437
           C+    S  +GFG  +                                     P    E 
Sbjct: 185 CLYFALSRYLGFGRDAWVYPDPAQPGFERLRRQYLYSFYFSTLILTTVGDTPPPAREEEY 244

Query: 438 VFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLE 497
           +F +   L+  + +A+I G++S++I  + +  A ++     VK++++   +   L +R+ 
Sbjct: 245 LFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNRKLERRVI 304

Query: 498 EYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKF 557
           +++QH        +  A+L+  PE L+A++ + +H + L     F       L  L +K 
Sbjct: 305 DWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEELVLKL 364

Query: 558 KTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVV--AILGKNDIFGEPVSLHAQPG 615
           +     PG+ +   GD+   +Y I  G + ++ DD +   A+LG    FGE   ++ +  
Sbjct: 365 QPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVLGAGLYFGEISIINIKGN 424

Query: 616 KS----SADVRALTYCDLHKIQRADLLEVLDMYP 645
            S    +A++++L Y DL  + + DL EVL  YP
Sbjct: 425 MSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYP 458


>gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [Homo
            sapiens]
          Length = 1251

 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 76/382 (19%), Positives = 171/382 (44%), Gaps = 42/382 (10%)

Query: 302  VVDLIVDIMFVVDI-VINFRTTYVNTNDEVVSHPRRIAVHYFKGW-FLIDMVAAIPFDLL 359
            ++D + D+++ +DI V   R  +V   D +++  + +  +Y K   F +D+++ +P D L
Sbjct: 693  LMDYLCDLIYFLDITVFQTRLQFVRGGD-IITDKKDMRNNYLKSRRFKMDLLSLLPLDFL 751

Query: 360  IFRTGSDE----------------TTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFL 403
              + G +                  + L  +L  A + R++R    L  YS +  + L+ 
Sbjct: 752  YLKVGVNPLLRLPRCLKYMAFFEFNSRLESILSKAYVYRVIRTTAYL-LYSLHLNSCLYY 810

Query: 404  LMCTFALIA--HWLA-------------CICSLTSVGFGNVSPNTNSEKVFSICVMLIGS 448
                +  +   HW+               + +L ++G G   P T  E VF +     G 
Sbjct: 811  WASAYQGLGSTHWVYDGVGNSYIRCYYFAVKTLITIG-GLPDPKTLFEIVFQLLNYFTGV 869

Query: 449  LMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTN 508
              ++ + G +  ++    +G   Y + M    +++ F++IP  ++ R++ ++++ W    
Sbjct: 870  FAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWHSQG 929

Query: 509  GIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKFKTTHAPPGDTL 568
             +D + ++   P+ ++ D+ + ++  ++     F G  +  +  +  + ++    P D +
Sbjct: 930  MLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYV 989

Query: 569  VHLGDVLSTLYFISRGSIEIL---RDDVVVAILGKNDIFGEPVSLHAQPG--KSSADVRA 623
               G++   +Y I  G +++L       V+  L    +FGE +SL A  G  + +A+V A
Sbjct: 990  CKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVFGE-ISLLAVGGGNRRTANVVA 1048

Query: 624  LTYCDLHKIQRADLLEVLDMYP 645
              + +L  + + DL E+L  YP
Sbjct: 1049 HGFTNLFILDKKDLNEILVHYP 1070


>gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]
          Length = 809

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 86/424 (20%), Positives = 172/424 (40%), Gaps = 51/424 (12%)

Query: 261 WLILLLVIYT--AVFTPYSAAFLLSDQDESRRGACSYTCSPLTVVDLIVDIMFVVDIV-I 317
           WL+L+ + Y     F P    F     D               + D+I DI+++ D++ I
Sbjct: 221 WLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWL---------IADIICDIIYLYDMLFI 271

Query: 318 NFRTTYVNTNDEVVSHPRRIAVHYFKGW-FLIDMVAAIPFDLLIFRTGSDETTTLIGLLK 376
             R  +V   D +V     +  HY     F +D+ + IPFD+     G +       +LK
Sbjct: 272 QPRLQFVRGGDIIVDS-NELRKHYRTSTKFQLDVASIIPFDICYLFFGFNPMFRANRMLK 330

Query: 377 TARLLRLVRVAR---------KLDRYSEYGAAVLFLLMCTFALIAHW------------- 414
                                ++ R + Y   +L +  C +   +++             
Sbjct: 331 YTSFFEFNHHLESIMDKAYIYRVIRTTGYLLFILHINACVYYWASNYEGIGTTRWVYDGE 390

Query: 415 ----LAC----ICSLTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLY 466
               L C    + +L ++G G   P T  E VF +     G  +++S+ G +  +I    
Sbjct: 391 GNEYLRCYYWAVRTLITIG-GLPEPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAAT 449

Query: 467 SGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQAD 526
           +    +   M     ++  + IP  +++R+  ++++ W     +D + +LK  P  +Q  
Sbjct: 450 ANQNYFRACMDDTIAYMNNYSIPKLVQKRVRTWYEYTWDSQRMLDESDLLKTLPTTVQLA 509

Query: 527 ICLHLHRALLQHCPAFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSI 586
           + + ++ +++     F G     +  + ++ K+    PGD +   G++   +Y I  G +
Sbjct: 510 LAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEV 569

Query: 587 EIL---RDDVVVAILGKNDIFGEPVSLHAQPG--KSSADVRALTYCDLHKIQRADLLEVL 641
           ++L       V+  L    +FGE +SL A  G  + +A+V A  + +L  + +  L E+L
Sbjct: 570 QVLGGPDGTKVLVTLKAGSVFGE-ISLLAAGGGNRRTANVVAHGFANLLTLDKKTLQEIL 628

Query: 642 DMYP 645
             YP
Sbjct: 629 VHYP 632


>gi|45383011 potassium voltage-gated channel, delayed-rectifier,
           subfamily S, member 2 [Homo sapiens]
          Length = 477

 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 39/140 (27%), Positives = 67/140 (47%), Gaps = 36/140 (25%)

Query: 347 LIDMVAAIPFDL-LIFRTGSDETTTLIGLLKTARLLRLVRVAR--KLDR----------- 392
           LID+++ +PF + L+     + T TL  L + A++LRL+R+ R  KL R           
Sbjct: 262 LIDLMSIVPFYITLVVNLVVESTPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGAT 321

Query: 393 ----YSEYGAAVLFLLM--CTFALIAH----------------WLACICSLTSVGFGNVS 430
               Y E G  +L+L +    F+++A+                W     S+T+VG+G+V 
Sbjct: 322 LKYSYKEVGLLLLYLSVGISIFSVVAYTIEKEENEGLATIPACWWWATVSMTTVGYGDVV 381

Query: 431 PNTNSEKVFSICVMLIGSLM 450
           P T + K+ +   +L G L+
Sbjct: 382 PGTTAGKLTASACILAGILV 401


>gi|6912444 potassium voltage-gated channel, subfamily G, member 2
           [Homo sapiens]
          Length = 466

 Score = 42.0 bits (97), Expect = 0.003
 Identities = 57/222 (25%), Positives = 88/222 (39%), Gaps = 54/222 (24%)

Query: 287 ESRRGACSYTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWF 346
           E  RG CS  C  L V++ +    F  + ++  R+    +    +  P  I         
Sbjct: 205 EEERGECSPKCRSLFVLETVCVAWFSFEFLL--RSLQAESKCAFLRAPLNI--------- 253

Query: 347 LIDMVAAIPFD---LLIFRTGSDETTTLIGLLKTARLLRLVRV--ARKLDRYS------- 394
            ID++A +PF    LL    G   T  L       RLLR +RV    +L R+S       
Sbjct: 254 -IDILALLPFYVSLLLGLAAGPGGTKLLERAGLVLRLLRALRVLYVMRLARHSLGLRSLG 312

Query: 395 --------EYGAAVLFLL--MCTFALIAH-------------------WLACICSLTSVG 425
                   E+G  +LFL   M  FA + H                   W A I S+T+VG
Sbjct: 313 LTMRRCAREFGLLLLFLCVAMALFAPLVHLAERELGARRDFSSVPASYWWAVI-SMTTVG 371

Query: 426 FGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYS 467
           +G++ P +   +V ++  +L G L+ A    ++     R YS
Sbjct: 372 YGDMVPRSLPGQVVALSSILSGILLMAFPVTSIFHTFSRSYS 413


>gi|7657289 potassium channel, subfamily V, member 1 [Homo sapiens]
          Length = 500

 Score = 41.6 bits (96), Expect = 0.003
 Identities = 38/145 (26%), Positives = 64/145 (44%), Gaps = 39/145 (26%)

Query: 347 LIDMVAAIPFDLLIF---RTGSDETTTLIGLLKTARLLRLVRVAR--KLDR--------- 392
           +ID++A +PF + +     +GS  T  L  + +  ++LRL+R  R  KL R         
Sbjct: 277 IIDLLAILPFYITLLVESLSGSQTTQELENVGRIVQVLRLLRALRMLKLGRHSTGLRSLG 336

Query: 393 ------YSEYGAAVLFLLM------------------CTFALI-AHWLACICSLTSVGFG 427
                 Y E G  +LFL +                   TF  +   W     S+T+VG+G
Sbjct: 337 MTITQCYEEVGLLLLFLSVGISIFSTVEYFAEQSIPDTTFTSVPCAWWWATTSMTTVGYG 396

Query: 428 NVSPNTNSEKVFSICVMLIGSLMYA 452
           ++ P+T + K+ +   +L G L+ A
Sbjct: 397 DIRPDTTTGKIVAFMCILSGILVLA 421


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.137    0.421 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,150,282
Number of Sequences: 37866
Number of extensions: 1813897
Number of successful extensions: 8695
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 47
Number of HSP's successfully gapped in prelim test: 116
Number of HSP's that attempted gapping in prelim test: 8339
Number of HSP's gapped (non-prelim): 418
length of query: 905
length of database: 18,247,518
effective HSP length: 111
effective length of query: 794
effective length of database: 14,044,392
effective search space: 11151247248
effective search space used: 11151247248
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.