Search of human proteins with 27437001

Search of human proteins with 27437001

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|27437001 potassium voltage-gated channel, subfamily H,
member 1 isoform 1 [Homo sapiens]
         (989 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|27437001 potassium voltage-gated channel, subfamily H, member...  1986   0.0  
gi|4504831 potassium voltage-gated channel, subfamily H, member ...  1916   0.0  
gi|22024390 potassium voltage-gated channel, subfamily H, member...  1439   0.0  
gi|27886648 potassium voltage-gated channel, subfamily H, member...  1100   0.0  
gi|27886646 potassium voltage-gated channel, subfamily H, member...  1093   0.0  
gi|13540549 potassium voltage-gated channel, subfamily H, member...   543   e-154
gi|27886667 potassium voltage-gated channel, subfamily H, member...   522   e-148
gi|38569493 potassium voltage-gated channel, subfamily H (eag-re...   504   e-142
gi|6912446 potassium voltage-gated channel, subfamily H, member ...   493   e-139
gi|27886653 potassium voltage-gated channel, subfamily H, member...   462   e-130
gi|26051273 voltage-gated potassium channel, subfamily H, member...   462   e-130
gi|4557729 voltage-gated potassium channel, subfamily H, member ...   461   e-129
gi|27886651 potassium voltage-gated channel, subfamily H, member...   416   e-116
gi|26051271 voltage-gated potassium channel, subfamily H, member...   408   e-113
gi|27886665 potassium voltage-gated channel, subfamily H, member...   316   6e-86
gi|116325989 hyperpolarization activated cyclic nucleotide-gated...   172   2e-42
gi|156071470 hyperpolarization activated cyclic nucleotide-gated...   165   2e-40
gi|4885407 hyperpolarization activated cyclic nucleotide-gated p...   165   2e-40
gi|38327037 hyperpolarization activated cyclic nucleotide-gated ...   158   3e-38
gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2 [...   147   6e-35
gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Ho...   147   6e-35
gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]    143   7e-34
gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1 [...   137   5e-32
gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [H...   137   5e-32
gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]    127   7e-29
gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]    103   1e-21
gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [H...   102   1e-21
gi|157074214 potassium channel, subfamily U, member 1 [Homo sapi...    44   0.001
gi|205361107 potassium channel, subfamily K, member 17 isoform 2...    43   0.001
gi|17025230 potassium channel, subfamily K, member 17 isoform 1 ...    43   0.001

>gi|27437001 potassium voltage-gated channel, subfamily H, member 1
           isoform 1 [Homo sapiens]
          Length = 989

 Score = 1986 bits (5144), Expect = 0.0
 Identities = 989/989 (100%), Positives = 989/989 (100%)

Query: 1   MTMAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEV 60
           MTMAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEV
Sbjct: 1   MTMAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEV 60

Query: 61  MQKSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQ 120
           MQKSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQ
Sbjct: 61  MQKSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQ 120

Query: 121 DKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHK 180
           DKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHK
Sbjct: 121 DKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHK 180

Query: 181 HSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVS 240
           HSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVS
Sbjct: 181 HSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVS 240

Query: 241 FKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDL 300
           FKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDL
Sbjct: 241 FKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDL 300

Query: 301 LSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLR 360
           LSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLR
Sbjct: 301 LSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLR 360

Query: 361 LGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLY 420
           LGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLY
Sbjct: 361 LGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLY 420

Query: 421 QLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFA 480
           QLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFA
Sbjct: 421 QLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFA 480

Query: 481 VAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYI 540
           VAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYI
Sbjct: 481 VAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYI 540

Query: 541 VSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTV 600
           VSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTV
Sbjct: 541 VSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTV 600

Query: 601 HCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCAN 660
           HCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCAN
Sbjct: 601 HCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCAN 660

Query: 661 VRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEER 720
           VRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEER
Sbjct: 661 VRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEER 720

Query: 721 MKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANH 780
           MKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANH
Sbjct: 721 MKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANH 780

Query: 781 SLVKASVVTVRESPATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARF 840
           SLVKASVVTVRESPATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARF
Sbjct: 781 SLVKASVVTVRESPATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARF 840

Query: 841 KDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSP 900
           KDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSP
Sbjct: 841 KDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSP 900

Query: 901 QDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTS 960
           QDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTS
Sbjct: 901 QDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTS 960

Query: 961 RRSSQSPQELFEISRPQSPESERDIFGAS 989
           RRSSQSPQELFEISRPQSPESERDIFGAS
Sbjct: 961 RRSSQSPQELFEISRPQSPESERDIFGAS 989


>gi|4504831 potassium voltage-gated channel, subfamily H, member 1
           isoform 2 [Homo sapiens]
          Length = 962

 Score = 1916 bits (4963), Expect = 0.0
 Identities = 962/989 (97%), Positives = 962/989 (97%), Gaps = 27/989 (2%)

Query: 1   MTMAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEV 60
           MTMAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEV
Sbjct: 1   MTMAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEV 60

Query: 61  MQKSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQ 120
           MQKSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQ
Sbjct: 61  MQKSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQ 120

Query: 121 DKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHK 180
           DKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHK
Sbjct: 121 DKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHK 180

Query: 181 HSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVS 240
           HSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVS
Sbjct: 181 HSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVS 240

Query: 241 FKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDL 300
           FKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDL
Sbjct: 241 FKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDL 300

Query: 301 LSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLR 360
           LSCLPYDVINAFENVDE                           GISSLFSSLKVVRLLR
Sbjct: 301 LSCLPYDVINAFENVDE---------------------------GISSLFSSLKVVRLLR 333

Query: 361 LGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLY 420
           LGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLY
Sbjct: 334 LGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLY 393

Query: 421 QLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFA 480
           QLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFA
Sbjct: 394 QLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFA 453

Query: 481 VAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYI 540
           VAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYI
Sbjct: 454 VAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYI 513

Query: 541 VSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTV 600
           VSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTV
Sbjct: 514 VSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTV 573

Query: 601 HCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCAN 660
           HCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCAN
Sbjct: 574 HCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCAN 633

Query: 661 VRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEER 720
           VRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEER
Sbjct: 634 VRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEER 693

Query: 721 MKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANH 780
           MKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANH
Sbjct: 694 MKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANH 753

Query: 781 SLVKASVVTVRESPATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARF 840
           SLVKASVVTVRESPATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARF
Sbjct: 754 SLVKASVVTVRESPATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARF 813

Query: 841 KDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSP 900
           KDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSP
Sbjct: 814 KDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSP 873

Query: 901 QDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTS 960
           QDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTS
Sbjct: 874 QDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTS 933

Query: 961 RRSSQSPQELFEISRPQSPESERDIFGAS 989
           RRSSQSPQELFEISRPQSPESERDIFGAS
Sbjct: 934 RRSSQSPQELFEISRPQSPESERDIFGAS 962


>gi|22024390 potassium voltage-gated channel, subfamily H, member 5
           isoform 1 [Homo sapiens]
          Length = 988

 Score = 1439 bits (3724), Expect = 0.0
 Identities = 734/1022 (71%), Positives = 828/1022 (81%), Gaps = 78/1022 (7%)

Query: 3   MAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQ 62
           M GG+RGLVAPQNTFLENIVRRS++++F+LGNAQIVDWP+VYSNDGFCKLSGYHRA+VMQ
Sbjct: 1   MPGGKRGLVAPQNTFLENIVRRSSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQ 60

Query: 63  KSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDK 122
           KSSTCSFMYGELTDK TIEKVRQTF+NYE N FE+L+YKKNRTPVWF+++IAPIRNE +K
Sbjct: 61  KSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEK 120

Query: 123 VVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHKHS 182
           VVLFLCTF DIT FKQPIEDDS KGW KFARLTRALT+SR VLQQL P + K E VHKHS
Sbjct: 121 VVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTP-MNKTEVVHKHS 179

Query: 183 RLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFK 242
           RLAEVLQLGSDILPQYKQEAPKTPPHIILHYC FKTTWDW+ILILTFYTAI+VPYNVSFK
Sbjct: 180 RLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFK 239

Query: 243 TRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLS 302
           T+QNN+AWLV+DS+VDVIFLVDIVLNFHTTFVGP GEVISDPKLIRMNYLKTWFVIDLLS
Sbjct: 240 TKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLS 299

Query: 303 CLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLG 362
           CLPYD+INAFENVDE                           GISSLFSSLKVVRLLRLG
Sbjct: 300 CLPYDIINAFENVDE---------------------------GISSLFSSLKVVRLLRLG 332

Query: 363 RVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQL 422
           RVARKLDHY+EYGAAVLVLLVCVFGL AHW+ACIWYSIGDYE+ DE T TI+ +SWLYQL
Sbjct: 333 RVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQL 392

Query: 423 AMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVA 482
           A+ IGTPY++N S +G WEGGPSK+S+Y+SSLYFTMTSLT++GFGNIAP+TD+EK+F+VA
Sbjct: 393 ALSIGTPYRYNTS-AGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVA 451

Query: 483 IMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVS 542
           +MM+GSLLYATIFGNVTTIFQQMYANTNRYHEMLN+VRDFLKLYQVPKGLSERVMDYIVS
Sbjct: 452 MMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVS 511

Query: 543 TWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHC 602
           TWSMS+GIDTEKVL ICPKDMRADICVHLNRKVF EHPAFRLASDGCLRALA+EFQT+HC
Sbjct: 512 TWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHC 571

Query: 603 APGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVR 662
           APGDLIYHAGESVD+LCFVVSGSLEVIQDDEVVAILGKGDVFGD+FWKE TLA +CANVR
Sbjct: 572 APGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVR 631

Query: 663 ALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMK 722
           ALTYCDLH+IKR+AL KVL+FYTAF++SFSRNL LT NLRKRI+FRKISDVK+EEEER++
Sbjct: 632 ALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLRKRIIFRKISDVKKEEEERLR 691

Query: 723 RKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANH-- 780
           +KNE  L +P DHPVR+LFQ+F+QQKE R      G      D E+  +  E  S  +  
Sbjct: 692 QKNEVTLSIPVDHPVRKLFQKFKQQKELRNQGSTQG------DPERNQLQVESRSLQNGA 745

Query: 781 SLVKASVVTVRESPATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGD-CAK------ 833
           S+   SVVTV +      S     TS   +  K     +  L P GG    C K      
Sbjct: 746 SITGTSVVTVSQITPIQTSLAYVKTS---ESLKQNNRDAMELKPNGGADQKCLKVNSPIR 802

Query: 834 -----RKSWARFKDACG----KSEDWNKVSKAESMETLPERTKASGEAT------LKKTD 878
                 K W R K+  G    K EDWN V+KAESM  L E  K+S          L+KTD
Sbjct: 803 MKNGNGKGWLRLKNNMGAHEEKKEDWNNVTKAESMGLLSEDPKSSDSENSVTKNPLRKTD 862

Query: 879 SCDSGITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIK 938
           SCDSGITKSDLRLD  GEARSP + SPI A+ KH FYPIPEQ LQ T+ EV+HELKEDI+
Sbjct: 863 SCDSGITKSDLRLDKAGEARSPLEHSPIQADAKHPFYPIPEQALQTTLQEVKHELKEDIQ 922

Query: 939 ALNAKMTNIEKQLSEILRILT-------SRRSSQSP---------QELFEISRPQSPESE 982
            L+ +MT +EKQ++EIL+IL+       S   SQ P         Q++F +SRP+SPES+
Sbjct: 923 LLSCRMTALEKQVAEILKILSEKSVPQASSPKSQMPLQVPPQIPCQDIFSVSRPESPESD 982

Query: 983 RD 984
           +D
Sbjct: 983 KD 984


>gi|27886648 potassium voltage-gated channel, subfamily H, member 5
           isoform 2 [Homo sapiens]
          Length = 624

 Score = 1100 bits (2845), Expect = 0.0
 Identities = 537/644 (83%), Positives = 585/644 (90%), Gaps = 29/644 (4%)

Query: 61  MQKSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQ 120
           MQKSSTCSFMYGELTDK TIEKVRQTF+NYE N FE+L+YKKNRTPVWF+++IAPIRNE 
Sbjct: 1   MQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEH 60

Query: 121 DKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHK 180
           +KVVLFLCTF DIT FKQPIEDDS KGW KFARLTRALT+SR VLQQL P + K E VHK
Sbjct: 61  EKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTP-MNKTEVVHK 119

Query: 181 HSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVS 240
           HSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYC FKTTWDW+ILILTFYTAI+VPYNVS
Sbjct: 120 HSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVS 179

Query: 241 FKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDL 300
           FKT+QNN+AWLV+DS+VDVIFLVDIVLNFHTTFVGP GEVISDPKLIRMNYLKTWFVIDL
Sbjct: 180 FKTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDL 239

Query: 301 LSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLR 360
           LSCLPYD+INAFENVDE                           GISSLFSSLKVVRLLR
Sbjct: 240 LSCLPYDIINAFENVDE---------------------------GISSLFSSLKVVRLLR 272

Query: 361 LGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLY 420
           LGRVARKLDHY+EYGAAVLVLLVCVFGL AHW+ACIWYSIGDYE+ DE T TI+ +SWLY
Sbjct: 273 LGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLY 332

Query: 421 QLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFA 480
           QLA+ IGTPY++N S +G WEGGPSK+S+Y+SSLYFTMTSLT++GFGNIAP+TD+EK+F+
Sbjct: 333 QLALSIGTPYRYNTS-AGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFS 391

Query: 481 VAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYI 540
           VA+MM+GSLLYATIFGNVTTIFQQMYANTNRYHEMLN+VRDFLKLYQVPKGLSERVMDYI
Sbjct: 392 VAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYI 451

Query: 541 VSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTV 600
           VSTWSMS+GIDTEKVL ICPKDMRADICVHLNRKVF EHPAFRLASDGCLRALA+EFQT+
Sbjct: 452 VSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTI 511

Query: 601 HCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCAN 660
           HCAPGDLIYHAGESVD+LCFVVSGSLEVIQDDEVVAILGKGDVFGD+FWKE TLA +CAN
Sbjct: 512 HCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACAN 571

Query: 661 VRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKR 704
           VRALTYCDLH+IKR+AL KVL+FYTAF++SFSRNL LT NLRKR
Sbjct: 572 VRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLRKR 615


>gi|27886646 potassium voltage-gated channel, subfamily H, member 5
           isoform 3 [Homo sapiens]
          Length = 611

 Score = 1093 bits (2827), Expect = 0.0
 Identities = 532/636 (83%), Positives = 581/636 (91%), Gaps = 29/636 (4%)

Query: 3   MAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQ 62
           M GG+RGLVAPQNTFLENIVRRS++++F+LGNAQIVDWP+VYSNDGFCKLSGYHRA+VMQ
Sbjct: 1   MPGGKRGLVAPQNTFLENIVRRSSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQ 60

Query: 63  KSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDK 122
           KSSTCSFMYGELTDK TIEKVRQTF+NYE N FE+L+YKKNRTPVWF+++IAPIRNE +K
Sbjct: 61  KSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEK 120

Query: 123 VVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHKHS 182
           VVLFLCTF DIT FKQPIEDDS KGW KFARLTRALT+SR VLQQL P + K E VHKHS
Sbjct: 121 VVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTP-MNKTEVVHKHS 179

Query: 183 RLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFK 242
           RLAEVLQLGSDILPQYKQEAPKTPPHIILHYC FKTTWDW+ILILTFYTAI+VPYNVSFK
Sbjct: 180 RLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFK 239

Query: 243 TRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLS 302
           T+QNN+AWLV+DS+VDVIFLVDIVLNFHTTFVGP GEVISDPKLIRMNYLKTWFVIDLLS
Sbjct: 240 TKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLS 299

Query: 303 CLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLG 362
           CLPYD+INAFENVDE                           GISSLFSSLKVVRLLRLG
Sbjct: 300 CLPYDIINAFENVDE---------------------------GISSLFSSLKVVRLLRLG 332

Query: 363 RVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQL 422
           RVARKLDHY+EYGAAVLVLLVCVFGL AHW+ACIWYSIGDYE+ DE T TI+ +SWLYQL
Sbjct: 333 RVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQL 392

Query: 423 AMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVA 482
           A+ IGTPY++N S +G WEGGPSK+S+Y+SSLYFTMTSLT++GFGNIAP+TD+EK+F+VA
Sbjct: 393 ALSIGTPYRYNTS-AGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVA 451

Query: 483 IMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVS 542
           +MM+GSLLYATIFGNVTTIFQQMYANTNRYHEMLN+VRDFLKLYQVPKGLSERVMDYIVS
Sbjct: 452 MMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVS 511

Query: 543 TWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHC 602
           TWSMS+GIDTEKVL ICPKDMRADICVHLNRKVF EHPAFRLASDGCLRALA+EFQT+HC
Sbjct: 512 TWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHC 571

Query: 603 APGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAIL 638
           APGDLIYHAGESVD+LCFVVSGSLEVIQDDEVVAIL
Sbjct: 572 APGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAIL 607


>gi|13540549 potassium voltage-gated channel, subfamily H, member 6
           isoform 1 [Homo sapiens]
          Length = 994

 Score =  543 bits (1398), Expect = e-154
 Identities = 298/751 (39%), Positives = 438/751 (58%), Gaps = 94/751 (12%)

Query: 7   RRGLVAPQNTFLENIVRR--SNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKS 64
           RRG VAPQNT+L+ I+R+       F++ NAQ+ +  I+Y NDGFC+L GY R EVMQ+ 
Sbjct: 4   RRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVMQQP 63

Query: 65  STCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVV 124
            TC F+ G  T    + ++ Q     E    +IL Y+K+ +     V + P++NE   V+
Sbjct: 64  CTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDGAVI 123

Query: 125 LFLCTFSDITAFKQPIEDDSCK-------------------------GWGKFA------- 152
           +F+  F D+          S                           G GK+        
Sbjct: 124 MFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQIPQ 183

Query: 153 --------RLTRALTSSRGVLQQLAPS--VQKGENVHKHSRLAEVLQLGSDILPQYKQEA 202
                    L +  +SS   ++ +AP   V++ +NV +  ++ +VL LG+D+LP+YK +A
Sbjct: 184 FTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTE--KVTQVLSLGADVLPEYKLQA 241

Query: 203 PKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSF------KTRQNNVAW-----L 251
           P+     ILHY  FK  WDW+IL+L  YTA+  PY+ +F      ++R+   ++      
Sbjct: 242 PRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPLT 301

Query: 252 VVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINA 311
           VVD IVD++F+VDIV+NF TT+V    EV+S P+ I ++Y K WF+ID+++ +P+D++  
Sbjct: 302 VVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLIF 361

Query: 312 FENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHY 371
               DE +  +G                             LK  RLLRL RVARKLD Y
Sbjct: 362 RTGSDETTTLIG----------------------------LLKTARLLRLVRVARKLDRY 393

Query: 372 IEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQ 431
            EYGAAVL LL+C F L AHW+ACIWY+IG+ E    + K      WL  L + +G  Y 
Sbjct: 394 SEYGAAVLFLLMCTFALIAHWLACIWYAIGNVERPYLEHKI----GWLDSLGVQLGKRY- 448

Query: 432 FNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLY 491
            NGS       GPS    Y+++LYFT +SLTSVGFGN++P+T+ EK+F++ +M+IGSL+Y
Sbjct: 449 -NGSDPA---SGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEKVFSICVMLIGSLMY 504

Query: 492 ATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGID 551
           A+IFGNV+ I Q++Y+ T RYH  +  V++F++ +Q+P  L +R+ +Y    WS + GID
Sbjct: 505 ASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGID 564

Query: 552 TEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHA 611
              VL+  P+ ++ADIC+HL+R + +  PAF  A  GCLRALA++F+T H  PGD + H 
Sbjct: 565 MNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKFKTTHAPPGDTLVHL 624

Query: 612 GESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHV 671
           G+ + +L F+  GS+E+++DD VVAILGK D+FG+     A   +S A+VRALTYCDLH 
Sbjct: 625 GDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEPVSLHAQPGKSSADVRALTYCDLHK 684

Query: 672 IKRDALQKVLEFYTAFSHSFSRNLILTYNLR 702
           I+R  L +VL+ Y AF+ SF   L +T+NLR
Sbjct: 685 IQRADLLEVLDMYPAFAESFWSKLEVTFNLR 715


>gi|27886667 potassium voltage-gated channel, subfamily H, member 8
           [Homo sapiens]
          Length = 1107

 Score =  522 bits (1345), Expect = e-148
 Identities = 287/715 (40%), Positives = 438/715 (61%), Gaps = 63/715 (8%)

Query: 8   RGLVAPQNTFLENIVRRSNDT--NFVLGNAQIVD-WPIVYSNDGFCKLSGYHRAEVMQKS 64
           +GL+APQNTFL+ I  R + T  NF+L NAQ+   +PIVY +DGFC+L+G+ R EVMQKS
Sbjct: 5   KGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEVMQKS 64

Query: 65  STCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVV 124
            +C F++G  T++  + ++ ++ E       EI+ YKKN +P W  + I PI+NE+  VV
Sbjct: 65  CSCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEKGDVV 124

Query: 125 LFLCTFSDITAFKQPI-----EDDSCKGWGKF-ARLTRALTSSRGVLQQLAPSVQKGENV 178
           LFL +F DIT  K  I     ++D  KG  +       A   SR VL  ++  +Q+ E  
Sbjct: 125 LFLASFKDITDTKVKITPEDKKEDKVKGRSRAGTHFDSARRRSRAVLYHISGHLQRREK- 183

Query: 179 HKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYN 238
               ++   + +     P+YK    K    I+LH+  FK  WDW+IL+ TFY A+ VPYN
Sbjct: 184 -NKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYN 242

Query: 239 VSF-------KTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNY 291
           V F        TR   V+    D  V+++F++DI+LNF TT+V  +G+VI + + I ++Y
Sbjct: 243 VCFIGNDDLSTTRSTTVS----DIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHY 298

Query: 292 LKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFS 351
           + TWF+IDL++ LP+D++ AF NV  V                             SL  
Sbjct: 299 VTTWFIIDLIAALPFDLLYAF-NVTVV-----------------------------SLVH 328

Query: 352 SLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTK 411
            LK VRLLRL R+ +KLD Y ++   VL LL+ +F L AHWMACIWY IG  E   ED  
Sbjct: 329 LLKTVRLLRLLRLLQKLDRYSQHSTIVLTLLMSMFALLAHWMACIWYVIGKME--REDNS 386

Query: 412 TIR-NNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIA 470
            ++    WL++L   + +PY  N +      GGPS  S YI++LYFT++SLTSVGFGN++
Sbjct: 387 LLKWEVGWLHELGKRLESPYYGNNT-----LGGPSIRSAYIAALYFTLSSLTSVGFGNVS 441

Query: 471 PSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPK 530
            +TD EKIF++  M+IG+L++A +FGNVT I Q+MY+  + YH     ++DF++++ +P+
Sbjct: 442 ANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQ 501

Query: 531 GLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCL 590
            L +R+++Y  +TWS++ GID+ ++L+  P ++R+DI +HLN+++  +   F  AS GCL
Sbjct: 502 QLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEIL-QLSLFECASRGCL 560

Query: 591 RALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWK 650
           R+L++  +T  CAPG+ +   G+++ ++ FV SGS+EV++D  V+AILGKGD+ G     
Sbjct: 561 RSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMVLAILGKGDLIGANLSI 620

Query: 651 EATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNL--ILTYNLRK 703
           +  + ++ A+V+ALTYCDL  I    L +VL+ Y  ++H F  ++   LTYNLR+
Sbjct: 621 KDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPEYAHKFVEDIQHDLTYNLRE 675


>gi|38569493 potassium voltage-gated channel, subfamily H
           (eag-related), member 3 [Homo sapiens]
          Length = 1083

 Score =  504 bits (1299), Expect = e-142
 Identities = 289/735 (39%), Positives = 437/735 (59%), Gaps = 76/735 (10%)

Query: 8   RGLVAPQNTFLENIVRRSNDT--NFVLGNAQIVD-WPIVYSNDGFCKLSGYHRAEVMQKS 64
           RGL+APQNTFL+ I  R + T  NFVLGNAQ+   +P+VY +DGFC L+G+ RAEVMQ+ 
Sbjct: 5   RGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEVMQRG 64

Query: 65  STCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVV 124
             CSF+YG  T +   +++R+  + ++    E+++Y+K+  P W  + + PI+NE+ +V 
Sbjct: 65  CACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEKGEVA 124

Query: 125 LFLCTFSDITAFKQPIEDDSCK--GWGKFARLTRALTS--------SRGVLQQLAPSVQK 174
           LFL +  DI+  K     D  K  G G+  R  RA +         SR VL  L+  +QK
Sbjct: 125 LFLVSHKDISETKNRGGPDRWKETGGGR-RRYGRARSKGFNANRRRSRAVLYHLSGHLQK 183

Query: 175 GENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAIL 234
            +   KH +L + +      LP+YK  A +  P I+LH    + TWD  IL+ T Y A+ 
Sbjct: 184 -QPKGKH-KLNKGVFGEKPNLPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAVT 241

Query: 235 VPYNVSFKTRQNNVAW----LVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMN 290
           VPY+V   T +   A      V D  V+V+F++DIVLNF TTFV  +G+V+  PK I ++
Sbjct: 242 VPYSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLH 301

Query: 291 YLKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLF 350
           Y+ TWF++D+++ LP+D+++AF    +V+ + G                           
Sbjct: 302 YVTTWFLLDVIAALPFDLLHAF----KVNVYFG--------------------------A 331

Query: 351 SSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDT 410
             LK VRLLRL R+  +LD Y +Y A VL LL+ VF L AHW+AC+W+ IG  EI   ++
Sbjct: 332 HLLKTVRLLRLLRLLPRLDRYSQYSAVVLTLLMAVFALLAHWVACVWFYIGQREIESSES 391

Query: 411 KTIRNNSWLYQLAMDIGTPYQF------NGSGSGKWE----------------GGPSKNS 448
           + +    WL +LA  + TPY         G+ SG+ +                GGPS  S
Sbjct: 392 E-LPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSDNCSSSSEANGTGLELLGGPSLRS 450

Query: 449 VYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYAN 508
            YI+SLYF ++SLTSVGFGN++ +TD EKIF++  M+IG+L++A +FGNVT I Q+MYA 
Sbjct: 451 AYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNVTAIIQRMYAR 510

Query: 509 TNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADIC 568
              YH     +RD+++++++PK L +R+++Y  +TW+++ GIDT ++LQ  P ++RADI 
Sbjct: 511 RFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQSLPDELRADIA 570

Query: 569 VHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEV 628
           +HL+++V  + P F  AS GCLRAL++  +   C PG+ + H G+++ +L FV SGS+EV
Sbjct: 571 MHLHKEVL-QLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQALYFVCSGSMEV 629

Query: 629 IQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFS 688
           ++   V+AILGKGD+ G    +   + ++ A+V+ LTYC L  ++   L   L  Y  F+
Sbjct: 630 LKGGTVLAILGKGDLIGCELPRREQVVKANADVKGLTYCVLQCLQLAGLHDSLALYPEFA 689

Query: 689 HSFSRNL--ILTYNL 701
             FSR L   L+YNL
Sbjct: 690 PRFSRGLRGELSYNL 704


>gi|6912446 potassium voltage-gated channel, subfamily H, member 4
           [Homo sapiens]
          Length = 1017

 Score =  493 bits (1269), Expect = e-139
 Identities = 283/727 (38%), Positives = 431/727 (59%), Gaps = 72/727 (9%)

Query: 8   RGLVAPQNTFLENIVRRSNDT--NFVLGNAQIV-DWPIVYSNDGFCKLSGYHRAEVMQKS 64
           +GL+APQNTFL+ I  R + T  NF+L NAQ    +PIVY +DGFC+L+GY R EVMQK+
Sbjct: 5   KGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEVMQKT 64

Query: 65  STCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVV 124
            +C F+YG  T +  ++++ +  E ++ +  EI  Y+K+ +  W  + + PI+NE  +VV
Sbjct: 65  CSCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEMGEVV 124

Query: 125 LFLCTFSDITAFKQP-----------IEDDSCKGWGKFARLTRALTSSRGVLQQLAPSV- 172
           LFL +F DIT    P             ++S    G   +   A   SR VL +L     
Sbjct: 125 LFLFSFKDITQSGSPGLGPQGGRGDSNHENSLGRRGATWKFRSARRRSRTVLHRLTGHFG 184

Query: 173 QKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTA 232
           ++G+   K +    V +    + P+YK  +      ++LHY V K  WD +IL+ TFY A
Sbjct: 185 RRGQGGMKANN--NVFEPKPSV-PEYKVASVGGSRCLLLHYSVSKAIWDGLILLATFYVA 241

Query: 233 ILVPYNVSFK----TRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIR 288
           + VPYNV F     T   +   LV D  V+++F++DI+LNF TT+V  +G+VIS P+ I 
Sbjct: 242 VTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSIG 301

Query: 289 MNYLKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISS 348
           ++YL TWF IDL++ LP+D++  F                                 ++S
Sbjct: 302 LHYLATWFFIDLIAALPFDLLYIFNIT------------------------------VTS 331

Query: 349 LFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDE 408
           L   LK VRLLRL R+ +KL+ Y +  A VL LL+ VF L AHWMACIWY IG  E+   
Sbjct: 332 LVHLLKTVRLLRLLRLLQKLERYSQCSAVVLTLLMSVFALLAHWMACIWYVIGRREMEAN 391

Query: 409 DTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGN 468
           D   + +  WL++L   +  PY  NGS      GGPS+ S YI++LYFT++SLTSVGFGN
Sbjct: 392 DP-LLWDIGWLHELGKRLEVPY-VNGS-----VGGPSRRSAYIAALYFTLSSLTSVGFGN 444

Query: 469 IAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQV 528
           +  +TD EKIF++  M+IG+L++A +FGNVT I Q+MY+  + YH  +  ++DF++++++
Sbjct: 445 VCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRL 504

Query: 529 PKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDG 588
           P+ L +R+++Y  +TW+++ GID  ++L+  P ++RADI +HLNR++  + P F  AS G
Sbjct: 505 PRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREIL-QLPLFGAASRG 563

Query: 589 CLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVF 648
           CLRAL++  +T  CAPG+ +   G+++ +  +V SGSLEV++D+ V+AILGKGD+ G   
Sbjct: 564 CLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMVLAILGKGDLIGADI 623

Query: 649 WKEAT----------LAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNL--I 696
            +             + ++ A+V+ALTYC L  +    L +VL  Y  +  +F   L   
Sbjct: 624 PEPGQEPGLGADPNFVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPEYGAAFRAGLPRD 683

Query: 697 LTYNLRK 703
           LT+NLR+
Sbjct: 684 LTFNLRQ 690


>gi|27886653 potassium voltage-gated channel, subfamily H, member 7
           isoform 1 [Homo sapiens]
          Length = 1196

 Score =  462 bits (1190), Expect = e-130
 Identities = 243/546 (44%), Positives = 346/546 (63%), Gaps = 49/546 (8%)

Query: 168 LAPSVQKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILIL 227
           +AP V K    +   ++ +VL LG+D+LP+YK + P+     ILHY  FK  WDW+IL+L
Sbjct: 359 IAPKV-KDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLL 417

Query: 228 TFYTAILVPYNVSF--------KTRQNNVAWL---VVDSIVDVIFLVDIVLNFHTTFVGP 276
             YTAI  PY+ +F        K R+   +     VVD IVD++F++DI++NF TT+V  
Sbjct: 418 VIYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQ 477

Query: 277 AGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPP 336
             EV+SDP  I ++Y K WF+ID+++ +P+D++                           
Sbjct: 478 NEEVVSDPAKIAIHYFKGWFLIDMVAAIPFDLL--------------------------- 510

Query: 337 PLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACI 396
            + G  S   ++L   LK  RLLRL RVARKLD Y EYGAAVL+LL+C+F L AHW+ACI
Sbjct: 511 -IFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFALIAHWLACI 569

Query: 397 WYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYF 456
           WY+IG+ E      K      WL  L   IG  Y  + S S     GPS    Y+++LYF
Sbjct: 570 WYAIGNVERPYLTDKI----GWLDSLGQQIGKRYNDSDSSS-----GPSIKDKYVTALYF 620

Query: 457 TMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEML 516
           T +SLTSVGFGN++P+T+ EKIF++ +M+IGSL+YA+IFGNV+ I Q++Y+ T RYH  +
Sbjct: 621 TFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQM 680

Query: 517 NSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVF 576
             V++F++ +Q+P  L +R+ +Y    W+ + GID   VL+  P+ ++ADIC+HLN+ + 
Sbjct: 681 LRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLL 740

Query: 577 KEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVA 636
           +   AFR AS GCLRALAM+F+T H  PGD + H G+ + +L F+  GS+E+++DD VVA
Sbjct: 741 QNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDDIVVA 800

Query: 637 ILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLI 696
           ILGK D+FG++    A   +S A+VRALTYCDLH I+R+ L +VL+ Y  FS  F  NL 
Sbjct: 801 ILGKNDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQREDLLEVLDMYPEFSDHFLTNLE 860

Query: 697 LTYNLR 702
           LT+NLR
Sbjct: 861 LTFNLR 866



 Score =  100 bits (249), Expect = 7e-21
 Identities = 48/130 (36%), Positives = 76/130 (58%), Gaps = 2/130 (1%)

Query: 7   RRGLVAPQNTFLENIVRRSNDTN--FVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKS 64
           RRG VAPQNTFL  I+R+    N  F++ NA++ +  I+Y NDGFC+++G+ R +VMQK 
Sbjct: 4   RRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVMQKP 63

Query: 65  STCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVV 124
            TC F++G  T +  I ++ Q     E    E+  Y KN +       I P++N++   +
Sbjct: 64  CTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEGVAM 123

Query: 125 LFLCTFSDIT 134
           +F+  F  +T
Sbjct: 124 MFIINFEYVT 133


>gi|26051273 voltage-gated potassium channel, subfamily H, member 2
           isoform c [Homo sapiens]
          Length = 819

 Score =  462 bits (1189), Expect = e-130
 Identities = 244/552 (44%), Positives = 340/552 (61%), Gaps = 59/552 (10%)

Query: 168 LAPSVQKGENVHKHSRLA-----EVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDW 222
           L P  QKG  V +  R++     EVL LG+D+LP+YK +AP+     ILHY  FK  WDW
Sbjct: 14  LRPRAQKGR-VRRAVRISSLVAQEVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDW 72

Query: 223 IILILTFYTAILVPYNVSFKTRQNNVA------------WLVVDSIVDVIFLVDIVLNFH 270
           +IL+L  YTA+  PY+ +F  ++                  VVD IVD++F+VDI++NF 
Sbjct: 73  LILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFR 132

Query: 271 TTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGF 330
           TT+V    EV+S P  I ++Y K WF+ID+++ +P+D++                     
Sbjct: 133 TTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIF------------------- 173

Query: 331 ADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAA 390
                         G   L   LK  RLLRL RVARKLD Y EYGAAVL LL+C F L A
Sbjct: 174 ------------GSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIA 221

Query: 391 HWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVY 450
           HW+ACIWY+IG+ E    D++      WL+ L   IG PY  +G G      GPS    Y
Sbjct: 222 HWLACIWYAIGNMEQPHMDSRI----GWLHNLGDQIGKPYNSSGLG------GPSIKDKY 271

Query: 451 ISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTN 510
           +++LYFT +SLTSVGFGN++P+T+ EKIF++ +M+IGSL+YA+IFGNV+ I Q++Y+ T 
Sbjct: 272 VTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTA 331

Query: 511 RYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVH 570
           RYH  +  VR+F++ +Q+P  L +R+ +Y    WS + GID   VL+  P+ ++ADIC+H
Sbjct: 332 RYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLH 391

Query: 571 LNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQ 630
           LNR + +    FR A+ GCLRALAM+F+T H  PGD + HAG+ + +L F+  GS+E+++
Sbjct: 392 LNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILR 451

Query: 631 DDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHS 690
            D VVAILGK D+FG+     A   +S  +VRALTYCDLH I RD L +VL+ Y  FS  
Sbjct: 452 GDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDH 511

Query: 691 FSRNLILTYNLR 702
           F  +L +T+NLR
Sbjct: 512 FWSSLEITFNLR 523


>gi|4557729 voltage-gated potassium channel, subfamily H, member 2
           isoform a [Homo sapiens]
          Length = 1159

 Score =  461 bits (1186), Expect = e-129
 Identities = 243/557 (43%), Positives = 344/557 (61%), Gaps = 59/557 (10%)

Query: 159 TSSRGVLQQLAPSVQKGENVHKHS-RLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFK 217
           TS R ++   AP ++  E  H  + ++ +VL LG+D+LP+YK +AP+     ILHY  FK
Sbjct: 353 TSDREII---APKIK--ERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFK 407

Query: 218 TTWDWIILILTFYTAILVPYNVSFKTRQNNVA------------WLVVDSIVDVIFLVDI 265
             WDW+IL+L  YTA+  PY+ +F  ++                  VVD IVD++F+VDI
Sbjct: 408 AVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDI 467

Query: 266 VLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDP 325
           ++NF TT+V    EV+S P  I ++Y K WF+ID+++ +P+D++                
Sbjct: 468 LINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIF-------------- 513

Query: 326 GKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCV 385
                              G   L   LK  RLLRL RVARKLD Y EYGAAVL LL+C 
Sbjct: 514 -----------------GSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCT 556

Query: 386 FGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPS 445
           F L AHW+ACIWY+IG+ E    D++      WL+ L   IG PY  +G G      GPS
Sbjct: 557 FALIAHWLACIWYAIGNMEQPHMDSRI----GWLHNLGDQIGKPYNSSGLG------GPS 606

Query: 446 KNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQM 505
               Y+++LYFT +SLTSVGFGN++P+T+ EKIF++ +M+IGSL+YA+IFGNV+ I Q++
Sbjct: 607 IKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRL 666

Query: 506 YANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRA 565
           Y+ T RYH  +  VR+F++ +Q+P  L +R+ +Y    WS + GID   VL+  P+ ++A
Sbjct: 667 YSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQA 726

Query: 566 DICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGS 625
           DIC+HLNR + +    FR A+ GCLRALAM+F+T H  PGD + HAG+ + +L F+  GS
Sbjct: 727 DICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGS 786

Query: 626 LEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYT 685
           +E+++ D VVAILGK D+FG+     A   +S  +VRALTYCDLH I RD L +VL+ Y 
Sbjct: 787 IEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYP 846

Query: 686 AFSHSFSRNLILTYNLR 702
            FS  F  +L +T+NLR
Sbjct: 847 EFSDHFWSSLEITFNLR 863



 Score =  106 bits (264), Expect = 1e-22
 Identities = 49/126 (38%), Positives = 75/126 (59%), Gaps = 2/126 (1%)

Query: 7   RRGLVAPQNTFLENIVRR--SNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKS 64
           RRG VAPQNTFL+ I+R+       F++ NA++ +  ++Y NDGFC+L GY RAEVMQ+ 
Sbjct: 4   RRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRP 63

Query: 65  STCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVV 124
            TC F++G  T +    ++ Q     E    EI  Y+K+ +     V + P++NE   V+
Sbjct: 64  CTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVI 123

Query: 125 LFLCTF 130
           +F+  F
Sbjct: 124 MFILNF 129


>gi|27886651 potassium voltage-gated channel, subfamily H, member 6
           isoform 2 [Homo sapiens]
          Length = 905

 Score =  416 bits (1068), Expect = e-116
 Identities = 256/751 (34%), Positives = 385/751 (51%), Gaps = 147/751 (19%)

Query: 7   RRGLVAPQNTFLENIVRR--SNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKS 64
           RRG VAPQNT+L+ I+R+       F++ NAQ+ +  I+Y NDGFC+L GY R EVMQ+ 
Sbjct: 4   RRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVMQQP 63

Query: 65  STCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVV 124
            TC F+ G  T    + ++ Q     E    +IL Y+K+ +     V + P++NE   V+
Sbjct: 64  CTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDGAVI 123

Query: 125 LFLCTFSDITAFKQPIEDDSCK-------------------------GWGKFA------- 152
           +F+  F D+          S                           G GK+        
Sbjct: 124 MFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQIPQ 183

Query: 153 --------RLTRALTSSRGVLQQLAPS--VQKGENVHKHSRLAEVLQLGSDILPQYKQEA 202
                    L +  +SS   ++ +AP   V++ +NV +  ++ +VL LG+D+LP+YK +A
Sbjct: 184 FTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTE--KVTQVLSLGADVLPEYKLQA 241

Query: 203 PKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSF------KTRQNNVAW-----L 251
           P+     ILHY  FK  WDW+IL+L  YTA+  PY+ +F      ++R+   ++      
Sbjct: 242 PRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPLT 301

Query: 252 VVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINA 311
           VVD IVD++F+VDIV+NF TT+V    EV+S P+ I ++Y K WF+ID+++ +P+D++  
Sbjct: 302 VVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLIF 361

Query: 312 FENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHY 371
               DE +  +G                             LK  RLLRL RVARKLD Y
Sbjct: 362 RTGSDETTTLIG----------------------------LLKTARLLRLVRVARKLDRY 393

Query: 372 IEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQ 431
            EYGAAVL LL+C F L AHW+ACI                                   
Sbjct: 394 SEYGAAVLFLLMCTFALIAHWLACI---------------------------------CS 420

Query: 432 FNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLY 491
               G G      +   V+   +    + + +  FGN+  S  I+++++      G+  Y
Sbjct: 421 LTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNV--SAIIQRLYS------GTARY 472

Query: 492 ATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGID 551
            T                    +ML  V++F++ +Q+P  L +R+ +Y    WS + GID
Sbjct: 473 HT--------------------QMLR-VKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGID 511

Query: 552 TEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHA 611
              VL+  P+ ++ADIC+HL+R + +  PAF  A  GCLRALA++F+T H  PGD + H 
Sbjct: 512 MNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKFKTTHAPPGDTLVHL 571

Query: 612 GESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHV 671
           G+ + +L F+  GS+E+++DD VVAILGK D+FG+     A   +S A+VRALTYCDLH 
Sbjct: 572 GDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEPVSLHAQPGKSSADVRALTYCDLHK 631

Query: 672 IKRDALQKVLEFYTAFSHSFSRNLILTYNLR 702
           I+R  L +VL+ Y AF+ SF   L +T+NLR
Sbjct: 632 IQRADLLEVLDMYPAFAESFWSKLEVTFNLR 662


>gi|26051271 voltage-gated potassium channel, subfamily H, member 2
           isoform b [Homo sapiens]
          Length = 888

 Score =  408 bits (1049), Expect = e-113
 Identities = 213/496 (42%), Positives = 305/496 (61%), Gaps = 59/496 (11%)

Query: 159 TSSRGVLQQLAPSVQKGENVHKHS-RLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFK 217
           TS R ++   AP ++  E  H  + ++ +VL LG+D+LP+YK +AP+     ILHY  FK
Sbjct: 353 TSDREII---APKIK--ERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFK 407

Query: 218 TTWDWIILILTFYTAILVPYNVSFKTRQNNVA------------WLVVDSIVDVIFLVDI 265
             WDW+IL+L  YTA+  PY+ +F  ++                  VVD IVD++F+VDI
Sbjct: 408 AVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDI 467

Query: 266 VLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDP 325
           ++NF TT+V    EV+S P  I ++Y K WF+ID+++ +P+D++                
Sbjct: 468 LINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIF-------------- 513

Query: 326 GKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCV 385
                              G   L   LK  RLLRL RVARKLD Y EYGAAVL LL+C 
Sbjct: 514 -----------------GSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCT 556

Query: 386 FGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPS 445
           F L AHW+ACIWY+IG+ E    D++      WL+ L   IG PY  +G G      GPS
Sbjct: 557 FALIAHWLACIWYAIGNMEQPHMDSRI----GWLHNLGDQIGKPYNSSGLG------GPS 606

Query: 446 KNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQM 505
               Y+++LYFT +SLTSVGFGN++P+T+ EKIF++ +M+IGSL+YA+IFGNV+ I Q++
Sbjct: 607 IKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRL 666

Query: 506 YANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRA 565
           Y+ T RYH  +  VR+F++ +Q+P  L +R+ +Y    WS + GID   VL+  P+ ++A
Sbjct: 667 YSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQA 726

Query: 566 DICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGS 625
           DIC+HLNR + +    FR A+ GCLRALAM+F+T H  PGD + HAG+ + +L F+  GS
Sbjct: 727 DICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGS 786

Query: 626 LEVIQDDEVVAILGKG 641
           +E+++ D VVAILG G
Sbjct: 787 IEILRGDVVVAILGMG 802



 Score =  106 bits (264), Expect = 1e-22
 Identities = 49/126 (38%), Positives = 75/126 (59%), Gaps = 2/126 (1%)

Query: 7   RRGLVAPQNTFLENIVRR--SNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKS 64
           RRG VAPQNTFL+ I+R+       F++ NA++ +  ++Y NDGFC+L GY RAEVMQ+ 
Sbjct: 4   RRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRP 63

Query: 65  STCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVV 124
            TC F++G  T +    ++ Q     E    EI  Y+K+ +     V + P++NE   V+
Sbjct: 64  CTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVI 123

Query: 125 LFLCTF 130
           +F+  F
Sbjct: 124 MFILNF 129


>gi|27886665 potassium voltage-gated channel, subfamily H, member 7
           isoform 2 [Homo sapiens]
          Length = 732

 Score =  316 bits (810), Expect = 6e-86
 Identities = 167/399 (41%), Positives = 241/399 (60%), Gaps = 49/399 (12%)

Query: 168 LAPSVQKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILIL 227
           +AP V K    +   ++ +VL LG+D+LP+YK + P+     ILHY  FK  WDW+IL+L
Sbjct: 352 IAPKV-KDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLL 410

Query: 228 TFYTAILVPYNVSF--------KTRQNNVAWL---VVDSIVDVIFLVDIVLNFHTTFVGP 276
             YTAI  PY+ +F        K R+   +     VVD IVD++F++DI++NF TT+V  
Sbjct: 411 VIYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQ 470

Query: 277 AGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPP 336
             EV+SDP  I ++Y K WF+ID+++ +P+D++                           
Sbjct: 471 NEEVVSDPAKIAIHYFKGWFLIDMVAAIPFDLL--------------------------- 503

Query: 337 PLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACI 396
            + G  S   ++L   LK  RLLRL RVARKLD Y EYGAAVL+LL+C+F L AHW+ACI
Sbjct: 504 -IFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFALIAHWLACI 562

Query: 397 WYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYF 456
           WY+IG+ E      K      WL  L   IG  Y  + S S     GPS    Y+++LYF
Sbjct: 563 WYAIGNVERPYLTDKI----GWLDSLGQQIGKRYNDSDSSS-----GPSIKDKYVTALYF 613

Query: 457 TMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEML 516
           T +SLTSVGFGN++P+T+ EKIF++ +M+IGSL+YA+IFGNV+ I Q++Y+ T RYH  +
Sbjct: 614 TFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQM 673

Query: 517 NSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKV 555
             V++F++ +Q+P  L +R+ +Y    W+ + GID   V
Sbjct: 674 LRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMV 712



 Score =  100 bits (249), Expect = 7e-21
 Identities = 48/130 (36%), Positives = 76/130 (58%), Gaps = 2/130 (1%)

Query: 7   RRGLVAPQNTFLENIVRRSNDTN--FVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKS 64
           RRG VAPQNTFL  I+R+    N  F++ NA++ +  I+Y NDGFC+++G+ R +VMQK 
Sbjct: 4   RRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVMQKP 63

Query: 65  STCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVV 124
            TC F++G  T +  I ++ Q     E    E+  Y KN +       I P++N++   +
Sbjct: 64  CTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEGVAM 123

Query: 125 LFLCTFSDIT 134
           +F+  F  +T
Sbjct: 124 MFIINFEYVT 133


>gi|116325989 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 1 [Homo sapiens]
          Length = 890

 Score =  172 bits (435), Expect = 2e-42
 Identities = 130/513 (25%), Positives = 227/513 (44%), Gaps = 56/513 (10%)

Query: 191 GSDILPQYKQEAPKTPPHIILH-YCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVA 249
           GS    + +QE  KT    I+H Y  F+  WD I+LI+     +++P  ++F T Q    
Sbjct: 115 GSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTP 174

Query: 250 WLVVDSIVDVIFLVDIVLNFHTTFVG-PAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDV 308
           W++ +   D +FL+D+++NF T  V   + E+I DPK+I+MNYLK+WFV+D +S +P D 
Sbjct: 175 WIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDY 234

Query: 309 INAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKL 368
           I  F  V++           G   ++            + + S L+++RL RL R   + 
Sbjct: 235 I--FLIVEK-----------GMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQW 281

Query: 369 DH--YIEYGAAVLVL----LVCVFGLAAHWMACIWYSIGDYEIFDED----TKTIRNNSW 418
           +   ++ Y  A  V+    L+ +  L  HW  C+ + +   + F  D       + N+SW
Sbjct: 282 EEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSW 341

Query: 419 LYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKI 478
                   G  Y +                    +L+  M+ +  +G+G  AP +  +  
Sbjct: 342 --------GKQYSY--------------------ALFKAMSHMLCIGYGAQAPVSMSDLW 373

Query: 479 FAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMD 538
             +  M++G+  YA   G+ T + Q + ++  +Y E    V  ++  +++P  + +++ D
Sbjct: 374 ITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHD 433

Query: 539 YIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQ 598
           Y    +   +  D E +L      +R +I     RK+    P F  A    + A+  + +
Sbjct: 434 YYEHRY-QGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLR 492

Query: 599 TVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSC 658
                PGD I   G     + F+  G   VI        L  G  FG++     T  +  
Sbjct: 493 FEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICL--LTKGRRT 550

Query: 659 ANVRALTYCDLHVIKRDALQKVLEFYTAFSHSF 691
           A+VRA TYC L+ +  D   +VLE Y     +F
Sbjct: 551 ASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAF 583


>gi|156071470 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 2 [Homo sapiens]
          Length = 889

 Score =  165 bits (418), Expect = 2e-40
 Identities = 135/577 (23%), Positives = 243/577 (42%), Gaps = 71/577 (12%)

Query: 191 GSDILPQYKQEAPKTPPHIILH-YCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVA 249
           GS    + +QE  K+    I+H Y  F+  WD+ +L+      I++P  ++F   +    
Sbjct: 184 GSQKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDETTAP 243

Query: 250 WLVVDSIVDVIFLVDIVLNFHTTFV-GPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDV 308
           W+V + + D  FL+D+VLNF T  V     E+I DP+ I+  YL+TWFV+D +S +P D 
Sbjct: 244 WIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDY 303

Query: 309 INAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKL 368
           I  F  V++           G   ++            + + S L+++RL RL R   + 
Sbjct: 304 I--FLIVEK-----------GIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQW 350

Query: 369 DH--YIEYGAAVLVLLVC----VFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQL 422
           +   ++ Y  A  V+ +C    +  L  HW  C+ + +   + F         N W+   
Sbjct: 351 EEIFHMTYDLASAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFP-------RNCWV--- 400

Query: 423 AMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVA 482
                     NG  +  W      + +Y  +L+  M+ +  +G+G  AP +  +    + 
Sbjct: 401 --------SINGMVNHSW------SELYSFALFKAMSHMLCIGYGRQAPESMTDIWLTML 446

Query: 483 IMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVS 542
            M++G+  YA   G+ T + Q + ++  +Y E    V  ++  +++P    +++ DY   
Sbjct: 447 SMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEH 506

Query: 543 TWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHC 602
            +   +  D + +L      +R +I     RK+    P F  A    + A+  + +    
Sbjct: 507 RY-QGKMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVF 565

Query: 603 APGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVR 662
            PGD I   G     + F+  G + V+        L  G  FG++     T  +  A+VR
Sbjct: 566 QPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGEICL--LTRGRRTASVR 623

Query: 663 ALTYCDLHVIKRDALQKVLEFYTAFSHSF------------SRNLIL-----------TY 699
           A TYC L+ +  D   +VLE Y     +F             +N IL            +
Sbjct: 624 ADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLHKVQHDLNSGVF 683

Query: 700 NLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHP 736
           N ++  + ++I    RE  ++ +      L  PP  P
Sbjct: 684 NNQENAIIQEIVKYDREMVQQAELGQRVGLFPPPPPP 720


>gi|4885407 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 4 [Homo sapiens]
          Length = 1203

 Score =  165 bits (417), Expect = 2e-40
 Identities = 129/516 (25%), Positives = 220/516 (42%), Gaps = 62/516 (12%)

Query: 191 GSDILPQYKQEAPKTPPHIILH-YCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVA 249
           GS    + +QE  K+    I+H Y  F+  WD  +L+L     I++P  ++F   +N   
Sbjct: 235 GSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTP 294

Query: 250 WLVVDSIVDVIFLVDIVLNFHTTFVGPAG-EVISDPKLIRMNYLKTWFVIDLLSCLPYDV 308
           W+V + + D  FL+D+VLNF T  V     E+I DP+ I+M YLK+WF++D +S +P D 
Sbjct: 295 WIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDY 354

Query: 309 INAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKL 368
           I         S                   +   +  I      L ++RLLRL R+ R +
Sbjct: 355 IFLIVETRIDSEVY----------------KTARALRIVRFTKILSLLRLLRLSRLIRYI 398

Query: 369 DHYIEYG------AAVLVLLVCVFG---LAAHWMACIWYSIGDYEIFDEDT----KTIRN 415
             + E        A+ +V +V + G   L  HW  C+ + +   + F +D       + N
Sbjct: 399 HQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVN 458

Query: 416 NSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDI 475
           NSW        G  Y +                    +L+  M+ +  +G+G  AP    
Sbjct: 459 NSW--------GKQYSY--------------------ALFKAMSHMLCIGYGRQAPVGMS 490

Query: 476 EKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSER 535
           +    +  M++G+  YA   G+ T + Q + ++  +Y E    V  ++  +++P    +R
Sbjct: 491 DVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQR 550

Query: 536 VMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAM 595
           + DY    +   +  D E +L    + +R +I     RK+    P F  A    + ++  
Sbjct: 551 IHDYYEHRY-QGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLT 609

Query: 596 EFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLA 655
           + +     PGD I   G     + F+  G + V+        L  G  FG++     T  
Sbjct: 610 KLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICL--LTRG 667

Query: 656 QSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSF 691
           +  A+VRA TYC L+ +  D   +VLE Y     +F
Sbjct: 668 RRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAF 703


>gi|38327037 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 3 [Homo sapiens]
          Length = 774

 Score =  158 bits (399), Expect = 3e-38
 Identities = 134/545 (24%), Positives = 232/545 (42%), Gaps = 73/545 (13%)

Query: 191 GSDILPQYKQEAPKTPPHIILH-YCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVA 249
           GS    + +QE  K+    I+H Y  F+  WD I+L+L     I++P  ++F   +N+  
Sbjct: 66  GSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEENSPP 125

Query: 250 WLVVDSIVDVIFLVDIVLNFHTTFVGPAG-EVISDPKLIRMNYLKTWFVIDLLSCLPYDV 308
           W+V + + D  FL+D+VLNF T  V   G E++  P+ IR  YL+TWF++DL+S +P D 
Sbjct: 126 WIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDY 185

Query: 309 INAFENVDEVSAFMGDPGKIGFADQIPPPLEGR-----ESQGISSLFSSLKVVRLLRLGR 363
                              I    ++ P L+        +  I      L ++RLLRL R
Sbjct: 186 -------------------IFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSR 226

Query: 364 VARKLDHYIE-----YGAAVLVL----LVCVFGLAAHWMACIWYSIGDYEIFDED----T 410
           + R +  + E     Y  A  V+    L+ +  L  HW  C+ + +   + F  D     
Sbjct: 227 LIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSI 286

Query: 411 KTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIA 470
             + N+SW  Q                            Y  +L+  M+ +  +G+G  A
Sbjct: 287 NHMVNHSWGRQ----------------------------YSHALFKAMSHMLCIGYGQQA 318

Query: 471 PSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPK 530
           P    +    +  M++G+  YA   G+ T + Q + ++  +Y E    V  ++  +++P 
Sbjct: 319 PVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPA 378

Query: 531 GLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCL 590
              +R+ +Y    +   +  D E +L    + +R +I     R +    P F  A    +
Sbjct: 379 DTRQRIHEYYEHRY-QGKMFDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFV 437

Query: 591 RALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWK 650
            A+  + +     PGDL+   G     + F+  G L V+        L  G  FG++   
Sbjct: 438 TAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTRLTDGSYFGEICL- 496

Query: 651 EATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSF---SRNLILTYNLRKRIVF 707
             T  +  A+VRA TYC L+ +  D    VLE +     +F   + + +L    +  I+ 
Sbjct: 497 -LTRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLLRIGKKNSILQ 555

Query: 708 RKISD 712
           RK S+
Sbjct: 556 RKRSE 560


>gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2
           [Homo sapiens]
          Length = 676

 Score =  147 bits (370), Expect = 6e-35
 Identities = 135/542 (24%), Positives = 244/542 (45%), Gaps = 88/542 (16%)

Query: 199 KQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNN--VAWLVVDSI 256
           K++A    P   L+Y      W   I +  FY   L+     F   Q+   + WLV+D  
Sbjct: 137 KKDAIVVDPSSNLYY-----RWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYS 191

Query: 257 VDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNY-LKTWFVIDLLSCLPYDVINAFENV 315
            DV++++D+++   T F+   G ++SD   +  +Y   T F +D+LS +P D+       
Sbjct: 192 ADVLYVLDVLVRARTGFL-EQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDL------- 243

Query: 316 DEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLD------ 369
               A++    K+G                  + +  ++  RLL+  R+    D      
Sbjct: 244 ----AYL----KVG------------------TNYPEVRFNRLLKFSRLFEFFDRTETRT 277

Query: 370 ---HYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDI 426
              +    G  VL +L+ +     HW ACI+++I  +  F  D       SW+Y    +I
Sbjct: 278 NYPNMFRIGNLVLYILIII-----HWNACIYFAISKFIGFGTD-------SWVYP---NI 322

Query: 427 GTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMI 486
             P   +G  S K          YI SLY++  +LT++G     P  D E +F V   ++
Sbjct: 323 SIPE--HGRLSRK----------YIYSLYWSTLTLTTIG-ETPPPVKDEEYLFVVVDFLV 369

Query: 487 GSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSM 546
           G L++ATI GNV ++   M A+   +   ++S++ +++  +V K L  RV+ +    W+ 
Sbjct: 370 GVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWAN 429

Query: 547 SRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGD 606
            + +D ++VL+  P  ++A+I ++++    K+   F+    G L  L ++ +    +PGD
Sbjct: 430 KKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGD 489

Query: 607 LIYHAGESVDSLCFVVSGSLEVIQDDEVV--AILGKGDVFGDVFWKEATLAQS----CAN 660
            I   G+    +  +  G L V+ DD V    +L  G  FG++       ++S     AN
Sbjct: 490 YICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTAN 549

Query: 661 VRALTYCDLHVIKRDALQKVLEFYTAFSHSF---SRNLILTYNLRKRIVFRKISDVKREE 717
           +R++ Y DL  + +D L + L  Y     +     R +++  NL    + R  +D K  E
Sbjct: 550 IRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELARAGADPKDLE 609

Query: 718 EE 719
           E+
Sbjct: 610 EK 611


>gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Homo
           sapiens]
          Length = 694

 Score =  147 bits (370), Expect = 6e-35
 Identities = 135/542 (24%), Positives = 244/542 (45%), Gaps = 88/542 (16%)

Query: 199 KQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNN--VAWLVVDSI 256
           K++A    P   L+Y      W   I +  FY   L+     F   Q+   + WLV+D  
Sbjct: 155 KKDAIVVDPSSNLYY-----RWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYS 209

Query: 257 VDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNY-LKTWFVIDLLSCLPYDVINAFENV 315
            DV++++D+++   T F+   G ++SD   +  +Y   T F +D+LS +P D+       
Sbjct: 210 ADVLYVLDVLVRARTGFL-EQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDL------- 261

Query: 316 DEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLD------ 369
               A++    K+G                  + +  ++  RLL+  R+    D      
Sbjct: 262 ----AYL----KVG------------------TNYPEVRFNRLLKFSRLFEFFDRTETRT 295

Query: 370 ---HYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDI 426
              +    G  VL +L+ +     HW ACI+++I  +  F  D       SW+Y    +I
Sbjct: 296 NYPNMFRIGNLVLYILIII-----HWNACIYFAISKFIGFGTD-------SWVYP---NI 340

Query: 427 GTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMI 486
             P   +G  S K          YI SLY++  +LT++G     P  D E +F V   ++
Sbjct: 341 SIPE--HGRLSRK----------YIYSLYWSTLTLTTIG-ETPPPVKDEEYLFVVVDFLV 387

Query: 487 GSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSM 546
           G L++ATI GNV ++   M A+   +   ++S++ +++  +V K L  RV+ +    W+ 
Sbjct: 388 GVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWAN 447

Query: 547 SRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGD 606
            + +D ++VL+  P  ++A+I ++++    K+   F+    G L  L ++ +    +PGD
Sbjct: 448 KKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGD 507

Query: 607 LIYHAGESVDSLCFVVSGSLEVIQDDEVV--AILGKGDVFGDVFWKEATLAQS----CAN 660
            I   G+    +  +  G L V+ DD V    +L  G  FG++       ++S     AN
Sbjct: 508 YICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTAN 567

Query: 661 VRALTYCDLHVIKRDALQKVLEFYTAFSHSF---SRNLILTYNLRKRIVFRKISDVKREE 717
           +R++ Y DL  + +D L + L  Y     +     R +++  NL    + R  +D K  E
Sbjct: 568 IRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELARAGADPKDLE 627

Query: 718 EE 719
           E+
Sbjct: 628 EK 629


>gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]
          Length = 664

 Score =  143 bits (361), Expect = 7e-34
 Identities = 123/491 (25%), Positives = 212/491 (43%), Gaps = 85/491 (17%)

Query: 212 HYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNN--VAWLVVDSIVDVIFLVDIVLNF 269
           +YC     W ++I +   Y   L+     F   Q    + WLV+D + DV+++ D+ +  
Sbjct: 140 YYC-----WLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIADLFIRL 194

Query: 270 HTTFVGPAGEVISDPKLIRMNYLKTW-FVIDLLSCLPYDVINAFENVDEVSAFMGDPGKI 328
            T F+   G ++ D K +R NY+ T  F +D+ S +P D+I                   
Sbjct: 195 RTGFL-EQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIY------------------ 235

Query: 329 GFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLD---------HYIEYGAAVL 379
            FA  I  P               ++  RLL   R+    D         +       VL
Sbjct: 236 -FAVDIHSP--------------EVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVL 280

Query: 380 VLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGK 439
            +LV +     HW ACI+Y+I     F  DT       W+Y    D    Y         
Sbjct: 281 YILVII-----HWNACIYYAISKSIGFGVDT-------WVYPNITDPEYGYLARE----- 323

Query: 440 WEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVT 499
                     YI  LY++  +LT++G     P  D E +F +   +IG L++ATI GNV 
Sbjct: 324 ----------YIYCLYWSTLTLTTIG-ETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVG 372

Query: 500 TIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQIC 559
           ++   M A    +   +++V+ +++  +V KG+  +V+ +    W+  + +D  ++L+  
Sbjct: 373 SMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNL 432

Query: 560 PKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLC 619
           P  +RA+I ++++    K+   F     G L  L ++ +    +PGD I   G+    + 
Sbjct: 433 PAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMY 492

Query: 620 FVVSGSLEVIQDDEVV--AILGKGDVFGDVF---WKEATLA-QSCANVRALTYCDLHVIK 673
            +  G L V+ DD V   A+L  G  FG++     K + +  +  AN+R+L Y DL  + 
Sbjct: 493 IIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLS 552

Query: 674 RDALQKVLEFY 684
           +D L + +  Y
Sbjct: 553 KDDLMEAVTEY 563


>gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1
           [Homo sapiens]
          Length = 759

 Score =  137 bits (345), Expect = 5e-32
 Identities = 124/548 (22%), Positives = 234/548 (42%), Gaps = 71/548 (12%)

Query: 220 WDWIILILTFYTAILVPYNVSFKTRQNNVA--WLVVDSIVDVIFLVDIVLNFHTTFVGPA 277
           W + I +   Y   +V     F   Q++    WL++D + D+++L+D+ +   T ++   
Sbjct: 237 WLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQG 296

Query: 278 GEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPP 337
             V  + KLI        F +D+LS +P D++                 K+G+       
Sbjct: 297 LLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYF---------------KLGWN------ 335

Query: 338 LEGRESQGISSLFSSLKVVRLLRLGRVA---RKLDHYIEYGAAVLVL-LVCVFGLAAHWM 393
                       +  +++ RLLR  R+    ++ +    Y     +  LV    +  HW 
Sbjct: 336 ------------YPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWN 383

Query: 394 ACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISS 453
           AC++YSI     F  DT       W+Y    DI  P           E G      Y+ S
Sbjct: 384 ACVFYSISKAIGFGNDT-------WVYP---DINDP-----------EFGRLARK-YVYS 421

Query: 454 LYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYH 513
           LY++  +LT++G     P  D E +F V   +IG L++ATI GN+ ++   M A    + 
Sbjct: 422 LYWSTLTLTTIG-ETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQ 480

Query: 514 EMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNR 573
             +++++ ++    V K + +RV+ +    W+  + +D ++VL+  P  +RA+I ++++ 
Sbjct: 481 ARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHL 540

Query: 574 KVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDE 633
              K+   F     G L  L ++ Q    +PGD I   G+    +  +  G L V+ DD 
Sbjct: 541 DTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDG 600

Query: 634 VV--AILGKGDVFGDVFWKEATLAQS----CANVRALTYCDLHVIKRDALQKVLEFY--- 684
           V    +L  G  FG++       +++     AN++++ Y DL  + +D L + L  Y   
Sbjct: 601 VTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDA 660

Query: 685 TAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRF 744
                   + +++   L    +    SD K  EE+  + +    L+      +   ++  
Sbjct: 661 KTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESM 720

Query: 745 RQQKEARL 752
           +Q+ + RL
Sbjct: 721 QQKLKQRL 728


>gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [Homo
           sapiens]
          Length = 690

 Score =  137 bits (345), Expect = 5e-32
 Identities = 124/548 (22%), Positives = 234/548 (42%), Gaps = 71/548 (12%)

Query: 220 WDWIILILTFYTAILVPYNVSFKTRQNNVA--WLVVDSIVDVIFLVDIVLNFHTTFVGPA 277
           W + I +   Y   +V     F   Q++    WL++D + D+++L+D+ +   T ++   
Sbjct: 168 WLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQG 227

Query: 278 GEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPP 337
             V  + KLI        F +D+LS +P D++                 K+G+       
Sbjct: 228 LLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYF---------------KLGWN------ 266

Query: 338 LEGRESQGISSLFSSLKVVRLLRLGRVA---RKLDHYIEYGAAVLVL-LVCVFGLAAHWM 393
                       +  +++ RLLR  R+    ++ +    Y     +  LV    +  HW 
Sbjct: 267 ------------YPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWN 314

Query: 394 ACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISS 453
           AC++YSI     F  DT       W+Y    DI  P           E G      Y+ S
Sbjct: 315 ACVFYSISKAIGFGNDT-------WVYP---DINDP-----------EFGRLARK-YVYS 352

Query: 454 LYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYH 513
           LY++  +LT++G     P  D E +F V   +IG L++ATI GN+ ++   M A    + 
Sbjct: 353 LYWSTLTLTTIG-ETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQ 411

Query: 514 EMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNR 573
             +++++ ++    V K + +RV+ +    W+  + +D ++VL+  P  +RA+I ++++ 
Sbjct: 412 ARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHL 471

Query: 574 KVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDE 633
              K+   F     G L  L ++ Q    +PGD I   G+    +  +  G L V+ DD 
Sbjct: 472 DTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDG 531

Query: 634 VV--AILGKGDVFGDVFWKEATLAQS----CANVRALTYCDLHVIKRDALQKVLEFY--- 684
           V    +L  G  FG++       +++     AN++++ Y DL  + +D L + L  Y   
Sbjct: 532 VTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDA 591

Query: 685 TAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRF 744
                   + +++   L    +    SD K  EE+  + +    L+      +   ++  
Sbjct: 592 KTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESM 651

Query: 745 RQQKEARL 752
           +Q+ + RL
Sbjct: 652 QQKLKQRL 659


>gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]
          Length = 575

 Score =  127 bits (318), Expect = 7e-29
 Identities = 112/479 (23%), Positives = 206/479 (43%), Gaps = 72/479 (15%)

Query: 220 WDWIILILTFYTAILVPYNVSFKTRQNN--VAWLVVDSIVDVIFLVDIVLNFHTTFVGPA 277
           W   ++    Y  I++     F   Q+   VAWLV+D   D+++L+D+V+ FHT F+   
Sbjct: 37  WLNTMVFPVMYNLIILVCRACFPDLQHGYLVAWLVLDYTSDLLYLLDMVVRFHTGFL-EQ 95

Query: 278 GEVISDPKLIRMNYLKTW-FVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPP 336
           G ++ D   I   Y++TW F +DL S +P DV+                  +      P 
Sbjct: 96  GILVVDKGRISSRYVRTWSFFLDLASLMPTDVVY-----------------VRLGPHTP- 137

Query: 337 PLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHYIEYGA-----AVLVLLVCVFGLAAH 391
                          +L++ R LR  R+    D      A      +  L++ +F +  H
Sbjct: 138 ---------------TLRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLMLYIF-VVIH 181

Query: 392 WMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYI 451
           W +C+++++  Y  F  D       +W+Y    D   P            G       Y+
Sbjct: 182 WNSCLYFALSRYLGFGRD-------AWVYP---DPAQP------------GFERLRRQYL 219

Query: 452 SSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNR 511
            S YF+   LT+VG     P+ + E +F V   ++  + +ATI G+++++   M      
Sbjct: 220 YSFYFSTLILTTVG-DTPPPAREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAA 278

Query: 512 YHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHL 571
           ++     V+ ++KL  V + L  RV+D+        +  +   +LQ  P+ +RA++ V +
Sbjct: 279 FYPDHALVKKYMKLQHVNRKLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSV 338

Query: 572 NRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQD 631
           +         F+      L  L ++ Q    +PG+ +   G+    +  +  G L V+ D
Sbjct: 339 HLSTLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVAD 398

Query: 632 DEVV--AILGKGDVFGDV----FWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFY 684
           D +   A+LG G  FG++         +  +  AN+++L Y DL  + ++ L++VL  Y
Sbjct: 399 DGITQYAVLGAGLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEY 457


>gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]
          Length = 809

 Score =  103 bits (256), Expect = 1e-21
 Identities = 103/531 (19%), Positives = 212/531 (39%), Gaps = 84/531 (15%)

Query: 222 WIILILTFYT--AILVPYNVSF--KTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPA 277
           W++L+   Y      +P  + F  +T  N   WL+ D I D+I+L D++           
Sbjct: 221 WLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQPRLQFVRG 280

Query: 278 GEVISDPKLIRMNY-LKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPP 336
           G++I D   +R +Y   T F +D+ S +P+D+   F                        
Sbjct: 281 GDIIVDSNELRKHYRTSTKFQLDVASIIPFDICYLFF----------------------- 317

Query: 337 PLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGL-AAHWMAC 395
                   G + +F + ++++          L+  ++      V+    + L   H  AC
Sbjct: 318 --------GFNPMFRANRMLKYTSFFEFNHHLESIMDKAYIYRVIRTTGYLLFILHINAC 369

Query: 396 IWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLY 455
           ++Y   +YE        I    W+Y            +G G+            Y+   Y
Sbjct: 370 VYYWASNYE-------GIGTTRWVY------------DGEGNE-----------YLRCYY 399

Query: 456 FTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEM 515
           + + +L ++G G   P T  E +F +     G  +++++ G +  +     AN N +   
Sbjct: 400 WAVRTLITIG-GLPEPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRAC 458

Query: 516 LNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKV 575
           ++    ++  Y +PK + +RV  +   TW   R +D   +L+  P  ++  + + +N  +
Sbjct: 459 MDDTIAYMNNYSIPKLVQKRVRTWYEYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFSI 518

Query: 576 FKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVI---QDD 632
             +   F+      +  + +  ++V   PGD +   GE    +  +  G ++V+      
Sbjct: 519 ISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGT 578

Query: 633 EVVAILGKGDVFGDVFWKEATLA-QSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSF 691
           +V+  L  G VFG++    A    +  ANV A  + +L  + +  LQ++L  Y       
Sbjct: 579 KVLVTLKAGSVFGEISLLAAGGGNRRTANVVAHGFANLLTLDKKTLQEILVHYPD----- 633

Query: 692 SRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQ 742
           S  +++    + R++ ++    K +  E    + +  L+ PP     +LF+
Sbjct: 634 SERILMK---KARVLLKQ----KAKTAEATPPRKDLALLFPPKEETPKLFK 677


>gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [Homo
            sapiens]
          Length = 1251

 Score =  102 bits (255), Expect = 1e-21
 Identities = 120/540 (22%), Positives = 213/540 (39%), Gaps = 107/540 (19%)

Query: 220  WDWIILILTFYTAILVPYNVSF--KTRQNNVAWLVVDSIVDVIFLVDI-VLNFHTTFVGP 276
            W + +++   +   L+P   +F  +T  N   WL++D + D+I+ +DI V      FV  
Sbjct: 659  WLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVR- 717

Query: 277  AGEVISDPKLIRMNYLKTW-FVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIP 335
             G++I+D K +R NYLK+  F +DLLS LP D +     V+ +         + F +   
Sbjct: 718  GGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVNPLLRLPRCLKYMAFFEF-- 775

Query: 336  PPLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMAC 395
                   +  + S+ S   V R++R          Y+ Y              + H  +C
Sbjct: 776  -------NSRLESILSKAYVYRVIRTTA-------YLLY--------------SLHLNSC 807

Query: 396  IWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLY 455
            ++Y    Y+                             G GS  W      NS YI   Y
Sbjct: 808  LYYWASAYQ-----------------------------GLGSTHWVYDGVGNS-YIRCYY 837

Query: 456  FTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEM 515
            F + +L ++G G   P T  E +F +     G   ++ + G +  +     A    Y   
Sbjct: 838  FAVKTLITIG-GLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSC 896

Query: 516  LNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKV 575
            ++S   ++  Y++PK +  RV  +   TW     +D  +++   P  MR D+ + +N  +
Sbjct: 897  MDSTVKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNI 956

Query: 576  FKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVI---QDD 632
              +   F+      +  +    ++V   P D +   GE    +  + +G ++V+      
Sbjct: 957  VSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGK 1016

Query: 633  EVVAILGKGDVFGDVFWKEATLA-----QSCANVRALTYCDLHVIKRDALQKVLEFYTAF 687
             V+  L  G VFG++    + LA     +  ANV A  + +L ++ +  L ++L  Y   
Sbjct: 1017 SVLVTLKAGSVFGEI----SLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPE- 1071

Query: 688  SHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAP------LILPPDHPVRRLF 741
                S+ L+                  R++  RM R N  P      LILPP     +LF
Sbjct: 1072 ----SQKLL------------------RKKARRMLRSNNKPKEEKSVLILPPRAGTPKLF 1109


>gi|157074214 potassium channel, subfamily U, member 1 [Homo
           sapiens]
          Length = 1149

 Score = 43.5 bits (101), Expect = 0.001
 Identities = 23/78 (29%), Positives = 41/78 (52%), Gaps = 4/78 (5%)

Query: 435 SGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATI 494
           SG    +G  S+N  Y  S+Y  M + ++VGFG++   T + + F +    +GSL+   +
Sbjct: 248 SGDPWLKGRNSQNISYFESIYLVMATTSTVGFGDVVAKTSLGRTF-IMFFTLGSLI---L 303

Query: 495 FGNVTTIFQQMYANTNRY 512
           F N      +++AN  +Y
Sbjct: 304 FANYIPEMVELFANKRKY 321


>gi|205361107 potassium channel, subfamily K, member 17 isoform 2
           [Homo sapiens]
          Length = 271

 Score = 43.1 bits (100), Expect = 0.001
 Identities = 17/72 (23%), Positives = 40/72 (55%), Gaps = 8/72 (11%)

Query: 433 NGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYA 492
           N +  G+WE         + S +F+++++T++G+GN++P+T   ++F +   ++G  L  
Sbjct: 94  NTTSMGRWE--------LVGSFFFSVSTITTIGYGNLSPNTMAARLFCIFFALVGIPLNL 145

Query: 493 TIFGNVTTIFQQ 504
            +   +  + QQ
Sbjct: 146 VVLNRLGHLMQQ 157


>gi|17025230 potassium channel, subfamily K, member 17 isoform 1
           [Homo sapiens]
          Length = 332

 Score = 43.1 bits (100), Expect = 0.001
 Identities = 17/72 (23%), Positives = 40/72 (55%), Gaps = 8/72 (11%)

Query: 433 NGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYA 492
           N +  G+WE         + S +F+++++T++G+GN++P+T   ++F +   ++G  L  
Sbjct: 94  NTTSMGRWE--------LVGSFFFSVSTITTIGYGNLSPNTMAARLFCIFFALVGIPLNL 145

Query: 493 TIFGNVTTIFQQ 504
            +   +  + QQ
Sbjct: 146 VVLNRLGHLMQQ 157


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.404 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,552,285
Number of Sequences: 37866
Number of extensions: 1603098
Number of successful extensions: 5062
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 65
Number of HSP's successfully gapped in prelim test: 33
Number of HSP's that attempted gapping in prelim test: 4841
Number of HSP's gapped (non-prelim): 168
length of query: 989
length of database: 18,247,518
effective HSP length: 112
effective length of query: 877
effective length of database: 14,006,526
effective search space: 12283723302
effective search space used: 12283723302
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.