Guide to the Human Genome
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Search of human proteins with 27262630

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|27262630 nuclear autoantigenic sperm protein isoform 3 [Homo
sapiens]
         (449 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|27262630 nuclear autoantigenic sperm protein isoform 3 [Homo ...   867   0.0  
gi|27262628 nuclear autoantigenic sperm protein isoform 2 [Homo ...   610   e-175
gi|27262634 nuclear autoantigenic sperm protein isoform 1 [Homo ...   610   e-175
gi|16262452 cingulin [Homo sapiens]                                    51   2e-06
gi|190341068 forkhead-associated (FHA) phosphopeptide binding do...    51   2e-06
gi|50658065 SMC4 structural maintenance of chromosomes 4-like 1 ...    51   2e-06
gi|50658063 SMC4 structural maintenance of chromosomes 4-like 1 ...    51   2e-06
gi|38569484 kinesin family member 21A [Homo sapiens]                   48   2e-05
gi|4758646 kinesin family member 3B [Homo sapiens]                     48   2e-05
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]                       47   4e-05
gi|4885583 Rho-associated, coiled-coil containing protein kinase...    46   8e-05
gi|31982906 cingulin-like 1 [Homo sapiens]                             46   8e-05
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap...    45   1e-04
gi|5454088 acidic (leucine-rich) nuclear phosphoprotein 32 famil...    45   1e-04
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi...    45   1e-04
gi|63252902 tropomyosin 1 alpha chain isoform 2 [Homo sapiens]         45   1e-04
gi|28460688 taxilin [Homo sapiens]                                     45   1e-04
gi|4503509 eukaryotic translation initiation factor 3, subunit 1...    45   2e-04
gi|63252906 tropomyosin 1 alpha chain isoform 7 [Homo sapiens]         45   2e-04
gi|63252896 tropomyosin 1 alpha chain isoform 3 [Homo sapiens]         45   2e-04
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]              45   2e-04
gi|221219020 NYD-SP11 protein [Homo sapiens]                           44   2e-04
gi|63252900 tropomyosin 1 alpha chain isoform 4 [Homo sapiens]         44   2e-04
gi|194097392 Golgi autoantigen, golgin subfamily a, 2 [Homo sapi...    44   2e-04
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    44   2e-04
gi|71061468 centromere protein E [Homo sapiens]                        44   2e-04
gi|118498356 kinectin 1 isoform a [Homo sapiens]                       44   3e-04
gi|33620775 kinectin 1 isoform a [Homo sapiens]                        44   3e-04
gi|169210053 PREDICTED: hypothetical protein [Homo sapiens]            44   3e-04
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...    44   3e-04

>gi|27262630 nuclear autoantigenic sperm protein isoform 3 [Homo
           sapiens]
          Length = 449

 Score =  867 bits (2240), Expect = 0.0
 Identities = 449/449 (100%), Positives = 449/449 (100%)

Query: 1   MAMESTATAAVAAELVSADKIEDVPAPSTSADKVESLDVDSEAKKLLGLGQKHLVMGDIP 60
           MAMESTATAAVAAELVSADKIEDVPAPSTSADKVESLDVDSEAKKLLGLGQKHLVMGDIP
Sbjct: 1   MAMESTATAAVAAELVSADKIEDVPAPSTSADKVESLDVDSEAKKLLGLGQKHLVMGDIP 60

Query: 61  AAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEG 120
           AAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEG
Sbjct: 61  AAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEG 120

Query: 121 EKTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAW 180
           EKTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAW
Sbjct: 121 EKTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAW 180

Query: 181 DMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAH 240
           DMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAH
Sbjct: 181 DMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAH 240

Query: 241 DRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEI 300
           DRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEI
Sbjct: 241 DRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEI 300

Query: 301 EELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKP 360
           EELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKP
Sbjct: 301 EELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKP 360

Query: 361 TDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENM 420
           TDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENM
Sbjct: 361 TDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENM 420

Query: 421 EEEAENQAESRAAVEGTVEAGATVESTAC 449
           EEEAENQAESRAAVEGTVEAGATVESTAC
Sbjct: 421 EEEAENQAESRAAVEGTVEAGATVESTAC 449


>gi|27262628 nuclear autoantigenic sperm protein isoform 2 [Homo
           sapiens]
          Length = 788

 Score =  610 bits (1574), Expect = e-175
 Identities = 341/468 (72%), Positives = 366/468 (78%), Gaps = 23/468 (4%)

Query: 4   ESTATAAVAAELVSAD--KIEDVPAPSTSADKVESLDVDSEAKKLLGLGQKHL------- 54
           E+ A  AV  +LV  +    E+ P  +T A +  +++  SE  +  G     L       
Sbjct: 322 ENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVN 381

Query: 55  ---VMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALE 111
              V+GD    +        L   K G    E   A     +   +L+  E+   G+ ++
Sbjct: 382 GPSVVGD-QTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVD 440

Query: 112 GVHVEEEEGEKTEDESLVENNDNI----------DETEGSEEDDKENDKTEEMPNDSVLE 161
               +    +  ED+  +  N+            +ETEGSEEDDKENDKTEEMPNDSVLE
Sbjct: 441 TKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLE 500

Query: 162 NKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQ 221
           NKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQ
Sbjct: 501 NKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQ 560

Query: 222 AVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAV 281
           AVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAV
Sbjct: 561 AVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAV 620

Query: 282 LNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTS 341
           LNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTS
Sbjct: 621 LNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTS 680

Query: 342 GFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPE 401
           GFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPE
Sbjct: 681 GFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPE 740

Query: 402 VNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAGATVESTAC 449
           VNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAGATVESTAC
Sbjct: 741 VNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAGATVESTAC 788



 Score =  280 bits (717), Expect = 1e-75
 Identities = 208/493 (42%), Positives = 273/493 (55%), Gaps = 49/493 (9%)

Query: 1   MAMESTATAAVAAELVSADKIEDVPAPSTSADKVESLDVDSEAKKLLGLGQKHLVMGDIP 60
           MAMESTATAAVAAELVSADKIEDVPAPSTSADKVESLDVDSEAKKLLGLGQKHLVMGDIP
Sbjct: 1   MAMESTATAAVAAELVSADKIEDVPAPSTSADKVESLDVDSEAKKLLGLGQKHLVMGDIP 60

Query: 61  AAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEG 120
           AAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEG
Sbjct: 61  AAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEG 120

Query: 121 EKTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLEL-- 178
           EKTEDESLVENNDNIDE    E  ++  D   E       E+KSL + E ++  + E+  
Sbjct: 121 EKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEK 180

Query: 179 -AWDMLDLAKIIFKRQE------------TKEAQLYAAQAHLKLGEV-SVESENYVQAVE 224
              + +D++K   + QE            ++EA+  AA       EV S + E  V   E
Sbjct: 181 GGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAE 240

Query: 225 EFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQ---YDEAVAQFSKSIEVIENRMAV 281
           E +S      Q  E  ++   E   ++ ++     +    ++ V    K    +E     
Sbjct: 241 EEKSVSGTDVQE-ECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAES 299

Query: 282 LNEQVKEAE-GSSAEYKKEIEELKELLPEIREKI--EDAKESQRSGNVAELALKATLVES 338
           L+  VK  + G     +K +    E    + E++  ++   ++ S  V   A +A+ VE+
Sbjct: 300 LDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEA 359

Query: 339 -STSGFTPG---------GGGSSVSMIASRKPTDGASSSNCVTD------ISHLVRKKRK 382
            S     PG         G  +  S++  + P +  +S   +T+      +   VR K  
Sbjct: 360 GSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLV 419

Query: 383 PEEE----SPRKDDAKKAKQEPEVNGGSGDAVP------SGNEVSENMEEEAENQAESRA 432
           P +E    S  + +A     + +V  G+ +  P      + NE ++  EE+ +   E+  
Sbjct: 420 PSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEG 479

Query: 433 AVEGTVEAGATVE 445
           + E   E   T E
Sbjct: 480 SEEDDKENDKTEE 492


>gi|27262634 nuclear autoantigenic sperm protein isoform 1 [Homo
           sapiens]
          Length = 790

 Score =  610 bits (1574), Expect = e-175
 Identities = 341/468 (72%), Positives = 366/468 (78%), Gaps = 23/468 (4%)

Query: 4   ESTATAAVAAELVSAD--KIEDVPAPSTSADKVESLDVDSEAKKLLGLGQKHL------- 54
           E+ A  AV  +LV  +    E+ P  +T A +  +++  SE  +  G     L       
Sbjct: 324 ENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVN 383

Query: 55  ---VMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALE 111
              V+GD    +        L   K G    E   A     +   +L+  E+   G+ ++
Sbjct: 384 GPSVVGD-QTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVD 442

Query: 112 GVHVEEEEGEKTEDESLVENNDNI----------DETEGSEEDDKENDKTEEMPNDSVLE 161
               +    +  ED+  +  N+            +ETEGSEEDDKENDKTEEMPNDSVLE
Sbjct: 443 TKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLE 502

Query: 162 NKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQ 221
           NKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQ
Sbjct: 503 NKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQ 562

Query: 222 AVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAV 281
           AVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAV
Sbjct: 563 AVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAV 622

Query: 282 LNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTS 341
           LNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTS
Sbjct: 623 LNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTS 682

Query: 342 GFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPE 401
           GFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPE
Sbjct: 683 GFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPE 742

Query: 402 VNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAGATVESTAC 449
           VNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAGATVESTAC
Sbjct: 743 VNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAGATVESTAC 790



 Score =  217 bits (552), Expect = 2e-56
 Identities = 172/462 (37%), Positives = 240/462 (51%), Gaps = 49/462 (10%)

Query: 32  DKVESLDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFY 91
           +++  LDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFY
Sbjct: 34  NRIIHLDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFY 93

Query: 92  GKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDETEGSEEDDKENDKT 151
           GKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDE    E  ++  D  
Sbjct: 94  GKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAM 153

Query: 152 EEMPNDSVLENKSLQENEEEEIGNLEL---AWDMLDLAKIIFKRQE------------TK 196
            E       E+KSL + E ++  + E+     + +D++K   + QE            ++
Sbjct: 154 GEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSE 213

Query: 197 EAQLYAAQAHLKLGEV-SVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAY 255
           EA+  AA       EV S + E  V   EE +S      Q  E  ++   E   ++ ++ 
Sbjct: 214 EAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQE-ECREKGGQEKQGEVIVSI 272

Query: 256 GYNSQ---YDEAVAQFSKSIEVIENRMAVLNEQVKEAE-GSSAEYKKEIEELKELLPEIR 311
               +    ++ V    K    +E     L+  VK  + G     +K +    E    + 
Sbjct: 273 EEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVL 332

Query: 312 EKI--EDAKESQRSGNVAELALKATLVES-STSGFTPG---------GGGSSVSMIASRK 359
           E++  ++   ++ S  V   A +A+ VE+ S     PG         G  +  S++  + 
Sbjct: 333 EQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQT 392

Query: 360 PTDGASSSNCVTD------ISHLVRKKRKPEEE----SPRKDDAKKAKQEPEVNGGSGDA 409
           P +  +S   +T+      +   VR K  P +E    S  + +A     + +V  G+ + 
Sbjct: 393 PIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEK 452

Query: 410 VP------SGNEVSENMEEEAENQAESRAAVEGTVEAGATVE 445
            P      + NE ++  EE+ +   E+  + E   E   T E
Sbjct: 453 SPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEE 494


>gi|16262452 cingulin [Homo sapiens]
          Length = 1203

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 49/241 (20%), Positives = 112/241 (46%), Gaps = 5/241 (2%)

Query: 97   ELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDETEGSEEDDKENDKTEEMPN 156
            + AR++  +L   L+G+  E E  ++++D+   +     ++    E +  E   T E+  
Sbjct: 930  DTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLT 989

Query: 157  DSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQ-ETKEAQLYAAQAHLKLGEVSVE 215
            D V   +   +    E+     A   L+  KI  +RQ +  + +L +++   K      +
Sbjct: 990  DRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQ 1049

Query: 216  SENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQY-DEAVAQFSKSIEV 274
             E+  Q ++E       ++  L++ +R L     +L +      Q+ ++   Q S  ++ 
Sbjct: 1050 LESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKA 1109

Query: 275  IENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIED-AKESQR--SGNVAELAL 331
            ++ ++    E+++  +G   + ++E+EE  E+  +++ +I+   K+S R  S + AE AL
Sbjct: 1110 LKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESAL 1169

Query: 332  K 332
            K
Sbjct: 1170 K 1170



 Score = 37.4 bits (85), Expect = 0.028
 Identities = 58/270 (21%), Positives = 109/270 (40%), Gaps = 25/270 (9%)

Query: 73  LGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEGEKTE--DESLVE 130
           L ++  ET+ E G     + K+  +L   +  +L   +E   +EEE GEK E     L +
Sbjct: 557 LQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQ 616

Query: 131 NNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSLQ-ENEEEEIGNLELAWDM-LDLAKI 188
              +  +T   E   KE  +T+E       E K LQ E + +E+       ++   LA +
Sbjct: 617 ARASAGDTRQVEVLKKELLRTQE-------ELKELQAERQSQEVAGRHRDRELEKQLAVL 669

Query: 189 IFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETH 248
             +    +E +    Q    L ++  + E   +A    ++   +  Q   A +  L ET 
Sbjct: 670 RVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRET- 728

Query: 249 YQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLP 308
                         E   +F + I  +E ++      V   E   A  + +++ L+    
Sbjct: 729 -------------QEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQ 775

Query: 309 EIREKIEDAKESQRSGNVAELALKATLVES 338
           ++ E +  ++E + S   A+ AL+A L E+
Sbjct: 776 QLEEALNASQEEEGSLAAAKRALEARLEEA 805



 Score = 34.3 bits (77), Expect = 0.24
 Identities = 61/235 (25%), Positives = 100/235 (42%), Gaps = 30/235 (12%)

Query: 106 LGNALEGVHVEEEEGEKTEDESLVENNDNIDETEGSEEDDK-----ENDKTEEMPNDSVL 160
           L   L  + VE + G + E+++L          +  EE  K     E + T      + +
Sbjct: 662 LEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAV 721

Query: 161 ENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLY-----AAQAHLKLGEVSVE 215
           E  +L+E +EE   N E    +L L       Q+ KE +       A +A L+     +E
Sbjct: 722 ET-TLRETQEE---NDEFRRRILGL------EQQLKETRGLVDGGEAVEARLRDKLQRLE 771

Query: 216 SENYVQAVEEFQSCLNLQEQYLEAHDRLLAET--HYQLGLA-YGYNSQ-YDEAVAQFSKS 271
           +E   Q +EE  +    +E  L A  R L       Q GLA  G   Q  + A+ +  K 
Sbjct: 772 AEK--QQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQ 829

Query: 272 IEVIENRMAVLNEQVKEAEGSSAEYKKEIEEL----KELLPEIREKIEDAKESQR 322
            EV+    A L EQ +  + +     KE+E++    K+ L +++ ++ED KE  R
Sbjct: 830 REVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKAR 884


>gi|190341068 forkhead-associated (FHA) phosphopeptide binding
           domain 1 [Homo sapiens]
          Length = 1412

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 46/201 (22%), Positives = 95/201 (47%), Gaps = 17/201 (8%)

Query: 115 VEEEEGEKTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSLQ-ENEEEEI 173
           V++ E   T+ + + E+N   ++ +  E  +KE  K +++ N    + + L+ + ++E++
Sbjct: 784 VQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDV 843

Query: 174 GNLELAWDMLDLAKIIFKRQETKEAQ-LYAAQAHLKLGEVSVESENYVQAVEEFQSCLNL 232
            N +L+    D   ++ + Q+TK  + L A    LKL E   E E     +   +  L L
Sbjct: 844 LNNKLS----DALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVEERLIL 899

Query: 233 QEQYLEA-HDRLLAETHYQLGLAYGYNS---QYDEAVAQFSKSIEVIENRMAVLNEQVKE 288
           Q++ ++A  D   ++ H       G+     +Y E + Q +++I  +E ++  + +  K+
Sbjct: 900 QQKMVKALQDEQESQRH-------GFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKK 952

Query: 289 AEGSSAEYKKEIEELKELLPE 309
            EG  A  K      KE  P+
Sbjct: 953 IEGEIATLKDNDPAPKEERPQ 973



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 71/319 (22%), Positives = 121/319 (37%), Gaps = 33/319 (10%)

Query: 39   VDSEAKKLLGLG-----QKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFYGK 93
            ++SE +K+  L      QK +   +I       +EA     KK  +  N   +      K
Sbjct: 777  LESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQ-----K 831

Query: 94   SLLELARMENGVLGNALEGVHVEEEEGEKTE-DESLVENNDNIDETEGSEEDDKENDKTE 152
              LEL   +  VL N L       EE +KT+  ESL   +  +   E   E +    K  
Sbjct: 832  EELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMI 891

Query: 153  EMPNDSVLEN---KSLQENEEEEIGNLELAWDMLDLAKIIFKRQET----KEAQLYAAQA 205
             +    +L+    K+LQ+ +E +    E   ++++  + I +  +T    +E      Q 
Sbjct: 892  MVEERLILQQKMVKALQDEQESQRHGFE--EEIMEYKEQIKQHAQTIVSLEEKLQKVTQH 949

Query: 206  HLKL-GEVSVESENYVQAVEEF-QSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDE 263
            H K+ GE++   +N     EE  Q  L        A D         L  A        E
Sbjct: 950  HKKIEGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQE 1009

Query: 264  AVAQFSKSIEVIENRMAVLNEQVKEAEGSSAE--------YKKEIEELKELLPEIREKIE 315
             + +  K +    +RM+ L  ++ E +    E          KE+  LKE + ++   +E
Sbjct: 1010 VIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVE 1069

Query: 316  DAKESQRSGNVAELALKAT 334
               +  R     E AL+A+
Sbjct: 1070 ---KKDRELKALEEALRAS 1085


>gi|50658065 SMC4 structural maintenance of chromosomes 4-like 1
           [Homo sapiens]
          Length = 1288

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 63/260 (24%), Positives = 107/260 (41%), Gaps = 17/260 (6%)

Query: 110 LEGVHVEEEEGEKTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSLQENE 169
           LE V V E+    T     +E     D+ E  EE      K+  + N++   N +L++ +
Sbjct: 395 LEDVQVREKLKHATSKAKKLEKQLQKDK-EKVEEFKSIPAKSNNIINETTTRNNALEKEK 453

Query: 170 EEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSC 229
           E+E   L+   D L        +QET+  Q        +L   S         ++  QS 
Sbjct: 454 EKEEKKLKEVMDSL--------KQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSE 505

Query: 230 LNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEA 289
           L++   YL  H+  ++    QL  A        E + +   +I  IE ++    +++KE 
Sbjct: 506 LDI---YLSRHNTAVS----QLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEK 558

Query: 290 EGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGGG 349
           E    +  +E    K L+ ++ +K+E+AK S          L A +++   SG  PG  G
Sbjct: 559 EKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDA-IIQEKKSGRIPGIYG 617

Query: 350 SSVSMIASRKPTDGASSSNC 369
               + A  +  D A SS C
Sbjct: 618 RLGDLGAIDEKYDVAISSCC 637



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 51/220 (23%), Positives = 97/220 (44%), Gaps = 45/220 (20%)

Query: 122  KTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWD 181
            KT D +L +  D++  TE      KE   TE+  +D   E KSL++   E + N   A +
Sbjct: 928  KTADRNLQKAQDSVLRTE------KEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEE 981

Query: 182  MLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHD 241
             L               ++     +L L E+ V  EN   A+++    + L+ + ++ H 
Sbjct: 982  SL--------------PEIQKEHRNL-LQELKVIQEN-EHALQKDALSIKLKLEQIDGH- 1024

Query: 242  RLLAETHYQLGLAYGYNSQY------DEAVAQFS----KSIEVIENRMAVLNE------- 284
              +AE + ++   +   S+       D  + + S    + +E I+N  ++ N+       
Sbjct: 1025 --IAEHNSKIKYWHKEISKISLHPIEDNPIEEISVLSPEDLEAIKNPDSITNQIALLEAR 1082

Query: 285  --QVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQR 322
              ++K   G+ AEYKK+ E   + + E+ +KI   ++S R
Sbjct: 1083 CHEMKPNLGAIAEYKKKEELYLQRVAEL-DKITYERDSFR 1121



 Score = 30.0 bits (66), Expect = 4.4
 Identities = 26/115 (22%), Positives = 48/115 (41%), Gaps = 14/115 (12%)

Query: 210 GEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFS 269
           GE ++  E      E F+   ++ + Y+    + +AE   Q         +  E   + +
Sbjct: 300 GEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQ-------KEKIHEDTKEIN 352

Query: 270 KSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLP-------EIREKIEDA 317
           +   ++ N M   N+ VK+ E    +  K IEE KE          ++REK++ A
Sbjct: 353 EKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHA 407


>gi|50658063 SMC4 structural maintenance of chromosomes 4-like 1
           [Homo sapiens]
          Length = 1288

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 63/260 (24%), Positives = 107/260 (41%), Gaps = 17/260 (6%)

Query: 110 LEGVHVEEEEGEKTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSLQENE 169
           LE V V E+    T     +E     D+ E  EE      K+  + N++   N +L++ +
Sbjct: 395 LEDVQVREKLKHATSKAKKLEKQLQKDK-EKVEEFKSIPAKSNNIINETTTRNNALEKEK 453

Query: 170 EEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSC 229
           E+E   L+   D L        +QET+  Q        +L   S         ++  QS 
Sbjct: 454 EKEEKKLKEVMDSL--------KQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSE 505

Query: 230 LNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEA 289
           L++   YL  H+  ++    QL  A        E + +   +I  IE ++    +++KE 
Sbjct: 506 LDI---YLSRHNTAVS----QLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEK 558

Query: 290 EGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGGG 349
           E    +  +E    K L+ ++ +K+E+AK S          L A +++   SG  PG  G
Sbjct: 559 EKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDA-IIQEKKSGRIPGIYG 617

Query: 350 SSVSMIASRKPTDGASSSNC 369
               + A  +  D A SS C
Sbjct: 618 RLGDLGAIDEKYDVAISSCC 637



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 51/220 (23%), Positives = 97/220 (44%), Gaps = 45/220 (20%)

Query: 122  KTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWD 181
            KT D +L +  D++  TE      KE   TE+  +D   E KSL++   E + N   A +
Sbjct: 928  KTADRNLQKAQDSVLRTE------KEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEE 981

Query: 182  MLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHD 241
             L               ++     +L L E+ V  EN   A+++    + L+ + ++ H 
Sbjct: 982  SL--------------PEIQKEHRNL-LQELKVIQEN-EHALQKDALSIKLKLEQIDGH- 1024

Query: 242  RLLAETHYQLGLAYGYNSQY------DEAVAQFS----KSIEVIENRMAVLNE------- 284
              +AE + ++   +   S+       D  + + S    + +E I+N  ++ N+       
Sbjct: 1025 --IAEHNSKIKYWHKEISKISLHPIEDNPIEEISVLSPEDLEAIKNPDSITNQIALLEAR 1082

Query: 285  --QVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQR 322
              ++K   G+ AEYKK+ E   + + E+ +KI   ++S R
Sbjct: 1083 CHEMKPNLGAIAEYKKKEELYLQRVAEL-DKITYERDSFR 1121



 Score = 30.0 bits (66), Expect = 4.4
 Identities = 26/115 (22%), Positives = 48/115 (41%), Gaps = 14/115 (12%)

Query: 210 GEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFS 269
           GE ++  E      E F+   ++ + Y+    + +AE   Q         +  E   + +
Sbjct: 300 GEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQ-------KEKIHEDTKEIN 352

Query: 270 KSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLP-------EIREKIEDA 317
           +   ++ N M   N+ VK+ E    +  K IEE KE          ++REK++ A
Sbjct: 353 EKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHA 407


>gi|38569484 kinesin family member 21A [Homo sapiens]
          Length = 1661

 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 52/219 (23%), Positives = 94/219 (42%), Gaps = 36/219 (16%)

Query: 108 NALEGVHVEEEEGEKTEDESLVENNDNIDETEGSEEDDKENDKTEEMPND-------SVL 160
           N LE    +E    + E+E   E  D+ID  E S+E D E+D+      D         +
Sbjct: 584 NELEVEESQEVSDHEDEEEEEEEEEDDIDGGESSDESDSESDEKANYQADLANITCEIAI 643

Query: 161 ENKSLQ--ENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESEN 218
           + K +   EN ++ +  L+  ++     K++  + + ++ QL   Q    LG V   SE 
Sbjct: 644 KQKLIDELENSQKRLQTLKKQYE----EKLMMLQHKIRDTQLERDQVLQNLGSVESYSEE 699

Query: 219 YVQAV----EEFQSCLNLQEQYLEA----HDRLLAETHYQLGLAYGYNSQYDEAVAQFSK 270
             + V    E+    +N + Q L+A    H RLL              SQY++ + +  +
Sbjct: 700 KAKKVRSEYEKKLQAMNKELQRLQAAQKEHARLLKN-----------QSQYEKQLKKLQQ 748

Query: 271 SIEVIENRMAVLNEQVKE----AEGSSAEYKKEIEELKE 305
            +  ++     L +Q+KE    A  + +   +EI +LK+
Sbjct: 749 DVMEMKKTKVRLMKQMKEEQEKARLTESRRNREIAQLKK 787



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 51/241 (21%), Positives = 114/241 (47%), Gaps = 39/241 (16%)

Query: 121 EKTEDESLVENNDNIDETEGSEED----DKENDKTEEMPNDSVLENKSLQENEEEEIGNL 176
           EK + +S+    DN D  +  +E+    ++EN++ E   +  V +++  +E EEEE  ++
Sbjct: 552 EKRKKKSVAGKEDNTDTDQEKKEEKGVSERENNELEVEESQEVSDHEDEEEEEEEEEDDI 611

Query: 177 ELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCL-NLQEQ 235
           +   +  D +       E+ E   Y A       E++++ +  +  +E  Q  L  L++Q
Sbjct: 612 D-GGESSDESD-----SESDEKANYQADLANITCEIAIK-QKLIDELENSQKRLQTLKKQ 664

Query: 236 YLEAHDRL---LAETHYQ-------LGLAYGYNSQYDEAV-AQFSKSIEVIENRMAVLNE 284
           Y E    L   + +T  +       LG    Y+ +  + V +++ K ++ +   +  L  
Sbjct: 665 YEEKLMMLQHKIRDTQLERDQVLQNLGSVESYSEEKAKKVRSEYEKKLQAMNKELQRLQA 724

Query: 285 QVKEAE---GSSAEYKKEIEELKE-----------LLPEIREKIEDAK--ESQRSGNVAE 328
             KE      + ++Y+K++++L++           L+ +++E+ E A+  ES+R+  +A+
Sbjct: 725 AQKEHARLLKNQSQYEKQLKKLQQDVMEMKKTKVRLMKQMKEEQEKARLTESRRNREIAQ 784

Query: 329 L 329
           L
Sbjct: 785 L 785



 Score = 33.1 bits (74), Expect = 0.53
 Identities = 34/193 (17%), Positives = 79/193 (40%), Gaps = 7/193 (3%)

Query: 258 NSQYDEAVAQFSKSIEVIENRMAVL-NEQVKEAEGSSAEYKKEIEELKELLPEIREKIED 316
           N+     +    ++++ + +R+  L ++Q       + E     EE+  ++    ++IED
Sbjct: 432 NNNLRVRIKAMQETVDALRSRITQLVSDQANHVLARAGEGN---EEISNMIHSYIKEIED 488

Query: 317 AKESQRSGNVAELALKATLVESSTSG-FTPGGGGSSVSMIASRKPTDGASSSNCVTDISH 375
            +            L+  L  ++    +  G    S ++++S K T          D+  
Sbjct: 489 LRAKLLESEAVNENLRKNLTRATARAPYFSGSSTFSPTILSSDKETIEIIDL-AKKDLEK 547

Query: 376 LVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENME-EEAENQAESRAAV 434
           L RK+++ ++    K+D     QE +   G  +   +  EV E+ E  + E++ E     
Sbjct: 548 LKRKEKRKKKSVAGKEDNTDTDQEKKEEKGVSERENNELEVEESQEVSDHEDEEEEEEEE 607

Query: 435 EGTVEAGATVEST 447
           E  ++ G + + +
Sbjct: 608 EDDIDGGESSDES 620


>gi|4758646 kinesin family member 3B [Homo sapiens]
          Length = 747

 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 57/243 (23%), Positives = 102/243 (41%), Gaps = 40/243 (16%)

Query: 100 RMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDETEGSEEDD--KENDKTEEMPND 157
           R E G  G    G   EEEEGE+ E+             EG ++DD  +E  +  E+   
Sbjct: 383 RREGGGSGG---GGEEEEEEGEEGEE-------------EGDDKDDYWREQQEKLEIEKR 426

Query: 158 SVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESE 217
           +++E+ SL   E+  +   E    M DL      R+E   A++  A+      ++ V  +
Sbjct: 427 AIVEDHSLVAEEKMRLLK-EKEKKMEDL------RREKDAAEMLGAKIKAMESKLLVGGK 479

Query: 218 NYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIEN 277
           N V    E Q  L  + Q +    R   E   Q+          DE   +  ++   ++ 
Sbjct: 480 NIVDHTNEQQKILEQKRQEIAEQKRREREIQQQM-------ESRDEETLELKETYSSLQQ 532

Query: 278 RMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGN--VAELALKATL 335
            + +  +++K+        K EI +L+E      E I++ +E +++ N    EL LK  +
Sbjct: 533 EVDIKTKKLKKLFSKLQAVKAEIHDLQE------EHIKERQELEQTQNELTRELKLKHLI 586

Query: 336 VES 338
           +E+
Sbjct: 587 IEN 589


>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
          Length = 793

 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 56/228 (24%), Positives = 100/228 (43%), Gaps = 33/228 (14%)

Query: 116 EEEEGEKTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGN 175
           E E  EK E     +    I+ETE   +  ++ND  +   N    E+K  +E EEE+   
Sbjct: 143 ENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKK--EDKEKEEEEEEKPKR 200

Query: 176 LELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVE----SENYVQAVEEFQSCLN 231
             +  + ++    +   ++T E+Q       LK G++S E     E   Q  +E      
Sbjct: 201 GSIGENQVE----VMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEK 256

Query: 232 LQEQYLEAHD----RLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEV--------IENRM 279
           ++E+  E  +    RL AE   ++       ++ D+ +A     IE          E R 
Sbjct: 257 MEEEDKERAEAERARLEAEERERI------KAEQDKKIADERARIEAEEKAAAQERERRE 310

Query: 280 AVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIED-----AKESQR 322
           A   E+++E E  +AE ++ I+E ++   E R++I++     A+E QR
Sbjct: 311 AEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQR 358



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 54/242 (22%), Positives = 101/242 (41%), Gaps = 16/242 (6%)

Query: 108 NALEGVHVEEEEGEKTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSLQE 167
           N  E    EEEE EK +  S+ EN   +   E + E  +E      + N  +   +  QE
Sbjct: 183 NKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEET-VVMSLKNGQISSEEPKQE 241

Query: 168 NEEE----EIGNLE-LAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGE--VSVESENYV 220
            E E    EI + E +  +  + A+    R E +E +   A+   K+ +    +E+E   
Sbjct: 242 EEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKA 301

Query: 221 QAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMA 280
            A E  +     +E+  E   R  AE   ++        + ++  A+  + I+  E R A
Sbjct: 302 AAQERERREAEERERMREEEKR-AAEERQRI-------KEEEKRAAEERQRIKEEEKRAA 353

Query: 281 VLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESST 340
              +++KE E  +AE ++     +E   ++ E+  + +  ++   + E  +K   VE   
Sbjct: 354 EERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKI 413

Query: 341 SG 342
            G
Sbjct: 414 EG 415



 Score = 37.0 bits (84), Expect = 0.036
 Identities = 49/228 (21%), Positives = 98/228 (42%), Gaps = 18/228 (7%)

Query: 116 EEEEGEKTEDES----LVENNDNIDETE--GSEEDDKENDK--TEEMPNDSVLENKSLQE 167
           EEEE  K E++     L E    + ET+  G + + K   K   E+   +  L+   L++
Sbjct: 376 EEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKK 435

Query: 168 NEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQ 227
             EE+   ++   + L   K  FK++E K+ ++       K  E   E ++++   + F 
Sbjct: 436 QGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKI------KKDKEPKEEVKSFMDRKKGFT 489

Query: 228 SCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQF--SKSIEVIENRMA-VLNE 284
              +   +++    +    T  + G     +++  E   Q    K +E +  R     +E
Sbjct: 490 EVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESE 549

Query: 285 QVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALK 332
           + ++ +    E   E+EELK+   E R K+ + +E +R    A+  L+
Sbjct: 550 EFEKLKQKQQEAALELEELKKKREE-RRKVLEEEEQRRKQEEADRKLR 596


>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
            [Homo sapiens]
          Length = 1354

 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 92/411 (22%), Positives = 161/411 (39%), Gaps = 38/411 (9%)

Query: 50   GQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNA 109
            G    ++GD+ A + + QE    L     +   E  EA      S  E   +E   L   
Sbjct: 618  GHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEID-LNYK 676

Query: 110  LEGVH--VEEEEGE-KTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSLQ 166
            L+ +   +E+E  E K     L + + +I+E +     + E    EE       EN+ +Q
Sbjct: 677  LKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQ 736

Query: 167  ENEEEEIGNLELAWDMLDLAKIIFKRQ----ETKEAQLYAAQAHLKLGEVSVESENYVQA 222
              ++  + +++L      L  +   ++    E K   L   Q   K   + +++E   QA
Sbjct: 737  IEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNK--RLLLQNELKTQA 794

Query: 223  VEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVL 282
             E   +   L++Q  +  + LL                 +  +AQ +K     E +M  L
Sbjct: 795  FEA-DNLKGLEKQMKQEINTLLEAKRL-----------LEFELAQLTKQYRGNEGQMREL 842

Query: 283  NEQVKEAEGSSAEYKKEIEELKELLPEIREK-IEDAKESQRSGNVAE-LALKATLVESST 340
             +Q++  +  S  YK +++ELKE   EI EK  E+ K+ Q   N  E LA +  L E+  
Sbjct: 843  QDQLEAEQYFSTLYKTQVKELKE---EIEEKNRENLKKIQELQNEKETLATQLDLAETKA 899

Query: 341  SGFTPGGGGSSVSMIASRKPTDGASSSNC--VTDISHLVRKKRKPEEESPRKDDAKKAKQ 398
                   G          + +  A+S N   +TD  H V   R  E  S    D +  ++
Sbjct: 900  ESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTV--SRLEEANSMLTKDIEILRR 957

Query: 399  EPEVNGGSGDAVPSGNEVSENMEEEAENQAES-RAAVEGTVEAGATVESTA 448
            E E      +      +  E  + E E +  + +AA E  +    T+++ A
Sbjct: 958  ENE------ELTEKMKKAEEEYKLEKEEEISNLKAAFEKNINTERTLKTQA 1002


>gi|31982906 cingulin-like 1 [Homo sapiens]
          Length = 1302

 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 66/318 (20%), Positives = 127/318 (39%), Gaps = 56/318 (17%)

Query: 129 VENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKI 188
           V+N  NI E       + E  +++   N+ V EN +LQ+  EE  G L    + L   K+
Sbjct: 634 VKNQQNIKEERERMRANLEELRSQH--NEKVEENSTLQQRLEESEGELRKNLEELFQVKM 691

Query: 189 IFKRQETK----EAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYL--EAHDR 242
             ++ +T+    + QL      L   + S + E      E  Q+  +LQ+  +  E  + 
Sbjct: 692 EREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQED 751

Query: 243 LLAETHYQLGLAYG---------------YNSQYD-------EAVAQFSKSIEVI----- 275
           LL +   +L    G                  QYD       E+V + +K++EV+     
Sbjct: 752 LLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSN 811

Query: 276 ---------ENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNV 326
                    E R+ +L E+ ++ +G S E ++ + +L+  + +++     AKE+ +    
Sbjct: 812 TSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEG 871

Query: 327 AELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDG---ASSSNCVTDISHLVRKKRKP 383
               L+  LV +                +++R+  +    A+  N         +   K 
Sbjct: 872 EIRQLEEALVHARK---------EEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKL 922

Query: 384 EEESPRKDDAKKAKQEPE 401
           +EES +K+  ++ K E E
Sbjct: 923 KEESEQKEQLRRLKNEME 940



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 53/217 (24%), Positives = 93/217 (42%), Gaps = 22/217 (10%)

Query: 117 EEEGEKTE----DESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEE 172
           E E  +TE     + L E +D +D  + SE+ +K     E +     L++  + + E+E+
Sbjct: 692 EREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQED 751

Query: 173 IGNLELAWDMLDLAKIIFKRQ---ETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSC 229
           +  L      L   K   K +     +E      Q   +L  +    E   + VE   S 
Sbjct: 752 L--LRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASR 809

Query: 230 LNLQEQ---YLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQV 286
            N  EQ     E   +LL E + +L    G + + +  VAQ  + IE ++   A   E +
Sbjct: 810 SNTSEQDQAGTEMRVKLLQEENEKL---QGRSEELERRVAQLQRQIEDLKGDEAKAKETL 866

Query: 287 KEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRS 323
           K+ EG       EI +L+E L   R++ ++A  ++R+
Sbjct: 867 KKYEG-------EIRQLEEALVHARKEEKEAVSARRA 896



 Score = 35.4 bits (80), Expect = 0.11
 Identities = 44/203 (21%), Positives = 85/203 (41%), Gaps = 17/203 (8%)

Query: 116 EEEEGEKTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGN 175
           E+E+  +  +  L      + E   S   D+E DK +E  +    E ++L+E+ EE   N
Sbjct: 748 EQEDLLRKRERELTALKGALKEEVSSH--DQEMDKLKEQYD---AELQALRESVEEATKN 802

Query: 176 LELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQ 235
           +E          ++  R  T E      +  +KL  +  E+E      EE +  +   ++
Sbjct: 803 VE----------VLASRSNTSEQDQAGTEMRVKL--LQEENEKLQGRSEELERRVAQLQR 850

Query: 236 YLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAE 295
            +E      A+    L    G   Q +EA+    K  +   +    L  +++ A+G+ ++
Sbjct: 851 QIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQ 910

Query: 296 YKKEIEELKELLPEIREKIEDAK 318
             +E ++L E L E  E+ E  +
Sbjct: 911 TTQEQKQLSEKLKEESEQKEQLR 933


>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
           sapiens]
          Length = 570

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 40/209 (19%), Positives = 93/209 (44%), Gaps = 18/209 (8%)

Query: 116 EEEEGEKTEDESLVENNDNIDETEGS--EEDDKENDKTEEMPNDSVLENKSLQENEEEEI 173
           E+EE  + ++E + E  + +   E    E+++K  +  E+M     +  +  +  EEE+I
Sbjct: 313 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKI 372

Query: 174 GNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQ 233
              E             KRQE +EA+++  +  ++  E  +  +   + ++E +  +  Q
Sbjct: 373 REQE-------------KRQE-QEAKMWRQEEKIREQEEKIREQE--EMMQEQEEKMGEQ 416

Query: 234 EQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSS 293
           E+ +   +  + E   ++        + ++ + +  + I   E  M    E++ E EG  
Sbjct: 417 EEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKM 476

Query: 294 AEYKKEIEELKELLPEIREKIEDAKESQR 322
            E + +++E +E +    EKI + ++  R
Sbjct: 477 CEQEAKMQEQEEKMRRQEEKIREQEKKIR 505



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 36/205 (17%), Positives = 91/205 (44%), Gaps = 9/205 (4%)

Query: 116 EEEEGEKTEDESLVENNDNIDETEGS-EEDDKENDKTEEMPNDSVLENKSLQENEEEEIG 174
           E+EE  + ++E + E  + I E E    E +K  ++ E+   +  +  +  ++ +E ++ 
Sbjct: 327 EKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMW 386

Query: 175 NLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQE 234
             E         KI  + ++ +E +    +   K+GE   +     + ++E +  +  QE
Sbjct: 387 RQE--------EKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQE 438

Query: 235 QYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSA 294
           + +   ++ + E   ++        + +E + +    +   E +M    E+++  E    
Sbjct: 439 EKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIR 498

Query: 295 EYKKEIEELKELLPEIREKIEDAKE 319
           E +K+I E +E + E  E +++ +E
Sbjct: 499 EQEKKIREQEEKIREQEEMMQEQEE 523



 Score = 36.6 bits (83), Expect = 0.048
 Identities = 37/223 (16%), Positives = 94/223 (42%), Gaps = 27/223 (12%)

Query: 126 ESLVENNDNIDETEGSEEDD--KENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDML 183
           ++ VE N+  +     +E+   ++ +K +E       + + ++E EE+     E+ W+  
Sbjct: 270 QAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKE 329

Query: 184 DLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEF----------------Q 227
           +  +   +    KE ++   +  +   E   E E   Q  E+                 +
Sbjct: 330 EKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQE 389

Query: 228 SCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVK 287
             +  QE+ +   + ++ E   ++G       + +E + +  + ++  E +M    E+++
Sbjct: 390 EKIREQEEKIREQEEMMQEQEEKMG-------EQEEKMWEQEEEMQEQEEKMRRQEEKIR 442

Query: 288 EAEGSSAEYKKEIEELKELLPEIREKI--EDAKESQRSGNVAE 328
           E E    E +++I E +E++ E  EK+  ++ K  ++   + E
Sbjct: 443 EQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQE 485



 Score = 34.7 bits (78), Expect = 0.18
 Identities = 34/198 (17%), Positives = 84/198 (42%), Gaps = 12/198 (6%)

Query: 116 EEEEGEKTEDESLVENNDNIDETEG--SEEDDKENDKTEEM--PNDSVLENKSLQENEEE 171
           E+E     ++E + E  + I E E    E+++K  ++ E+M    + + E +     +EE
Sbjct: 380 EQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEE 439

Query: 172 EIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLN 231
           +I   E         KI  + ++ +E +    +   K+GE   +       ++E +  + 
Sbjct: 440 KIREQE--------KKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMR 491

Query: 232 LQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEG 291
            QE+ +   ++ + E   ++        + +E + +  + +   E +M    E+++  E 
Sbjct: 492 RQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEE 551

Query: 292 SSAEYKKEIEELKELLPE 309
              E +  + + +E + E
Sbjct: 552 KMREQEVRLRQQEEKMQE 569


>gi|5454088 acidic (leucine-rich) nuclear phosphoprotein 32 family,
           member B [Homo sapiens]
          Length = 251

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 24/64 (37%), Positives = 38/64 (59%), Gaps = 2/64 (3%)

Query: 111 EGVHVEEEEGEKTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSLQENEE 170
           EG   E+E+ E  E+E   E +D  ++ EG E+DD+ +++ EE   D   E++   E+EE
Sbjct: 173 EGEDEEDEDDEDGEEEEFDEEDDEDEDVEGDEDDDEVSEEEEEFGLDE--EDEDEDEDEE 230

Query: 171 EEIG 174
           EE G
Sbjct: 231 EEEG 234



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 13/55 (23%), Positives = 30/55 (54%)

Query: 119 EGEKTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEI 173
           +G   ED+   +++  +D  +  EED++  D+ +E   D   E    +++E+E++
Sbjct: 146 DGYDREDQEAPDSDAEVDGVDEEEEDEEGEDEEDEDDEDGEEEEFDEEDDEDEDV 200


>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 436

 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 45/239 (18%), Positives = 98/239 (41%), Gaps = 17/239 (7%)

Query: 100 RMENGVLGNALEGVHVEEEE--GEKTEDESLVENNDNIDETEGSEEDDKENDKTEEMPND 157
           R + G +G   EG   E+EE  GE+ E     E      E +  +++++  ++ E++   
Sbjct: 188 REQEGQMGEQ-EGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQ 246

Query: 158 SVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESE 217
                K  ++  ++E    E    M +  + + K++E  E +    +   ++ E   +  
Sbjct: 247 EEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMR 306

Query: 218 NYVQAVEEFQSCLNLQEQYLEAHDRLLAE--------------THYQLGLAYGYNSQYDE 263
              + + E +  +  QE+ +   +  + E                 Q+G       + +E
Sbjct: 307 EQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEE 366

Query: 264 AVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQR 322
            V +  + +   E +M    EQ+++ E    E K+++ E KE + E  E++ + KE  R
Sbjct: 367 QVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMR 425



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 37/209 (17%), Positives = 87/209 (41%), Gaps = 12/209 (5%)

Query: 115 VEEEEGEKTEDESLV-ENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEI 173
           V E+EG+  E E  V E    + E EG   + +   + +E     V E +     +E ++
Sbjct: 68  VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE---GQVREQEGQVREQEGQV 124

Query: 174 GNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQ 233
              E         ++  +  + +E +    +   ++ E   +       V E +  +  Q
Sbjct: 125 REQE--------GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 176

Query: 234 EQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSS 293
           E  +   +  + E   Q+G   G   + +E + +  + ++  E +M    EQ+++ E   
Sbjct: 177 EGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQM 236

Query: 294 AEYKKEIEELKELLPEIREKIEDAKESQR 322
            E ++++++ +E + +  E++   +E  R
Sbjct: 237 GEQEEQVQKQEEQVQKQEEQMRKQEEQMR 265



 Score = 28.9 bits (63), Expect = 9.9
 Identities = 54/278 (19%), Positives = 103/278 (37%), Gaps = 25/278 (8%)

Query: 160 LENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENY 219
           L+ K+ +  EE ++   E +   L + ++  K +  K       Q   + G+V  E E  
Sbjct: 9   LKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVR-EQEGQ 67

Query: 220 VQA----VEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVI 275
           V+     V E +  +  QE  +   +  + E   Q+    G   + +  V +    +   
Sbjct: 68  VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 127

Query: 276 ENRMAVLNEQVKEAEGSSAEYKKEIEE----LKELLPEIREKIEDAKESQRSGNVAELAL 331
           E ++     QV+E EG   E + ++ E    ++E   ++RE+    +E +  G V E   
Sbjct: 128 EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE--GQVREQEG 185

Query: 332 KATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKD 391
           +    E        G  G     +  ++   G               ++   +EE  RK 
Sbjct: 186 QVREQE--------GQMGEQEGQMGEQEEQMGEQEEQMQKQ-----EEQMGEQEEQMRKQ 232

Query: 392 DAKKAKQEPEVNGGSGDAVPSGNEVSENMEEEAENQAE 429
           + +  +QE +V     + V    E     EE+   Q E
Sbjct: 233 EEQMGEQEEQVQ-KQEEQVQKQEEQMRKQEEQMREQEE 269


>gi|63252902 tropomyosin 1 alpha chain isoform 2 [Homo sapiens]
          Length = 284

 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 52/235 (22%), Positives = 98/235 (41%), Gaps = 32/235 (13%)

Query: 95  LLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENN-DNIDETEGS-----EEDDKEN 148
           L EL + E+ +L         E +         LVE   D   E   +     EE +K  
Sbjct: 61  LEELHKAEDSLLAAEEAAAKAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAA 120

Query: 149 DKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLK 208
           D++E      V+E+++ ++ E+ EI  ++L                 KEA+  A  A  K
Sbjct: 121 DESER--GMKVIESRAQKDEEKMEIQEIQL-----------------KEAKHIAEDADRK 161

Query: 209 LGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQF 268
             EV+       + +   +S L   E+  E  +   AE   +L          +    ++
Sbjct: 162 YEEVA-------RKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKY 214

Query: 269 SKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRS 323
           S+  +  E  + VL++++KEAE  +   ++ + +L++ + ++ EK+  AKE   S
Sbjct: 215 SQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEEKVAHAKEENLS 269


>gi|28460688 taxilin [Homo sapiens]
          Length = 546

 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 71/308 (23%), Positives = 131/308 (42%), Gaps = 55/308 (17%)

Query: 42  EAKKLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARM 101
           E KK  GLG++  ++      ++  +E  + L KKY E   E   +     +  ++L + 
Sbjct: 161 EKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNS-----QKQMKLLQK 215

Query: 102 ENGVLGNALEGVHVEEEEG--EKTEDESL---VENNDNIDETEGSEEDDKENDKTEEMP- 155
           +   L    + +  E  +    +++ ESL   ++ ++   + EG +   +E +K +E+  
Sbjct: 216 KQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTS 275

Query: 156 ------NDSVL--------------ENKSLQENEEEEIGNLELAWDMLDLAKIIFK---- 191
                 ND  L              EN  L E  ++ I   EL  + +D    +FK    
Sbjct: 276 HFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEHIDK---VFKHKDL 332

Query: 192 RQETKEAQLYAAQAHLKLGEVSVESEN---YVQAVEEFQSCLNLQEQYLEAHDRLLAETH 248
           +Q+  +A+L  AQ  LK  E   + E      +AVE  + C  +++Q          ETH
Sbjct: 333 QQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQRMCELMKQQ----------ETH 382

Query: 249 YQLGLAYGYNSQYDEAVAQFSKSIEV---IENRMAVLNEQVKEAEGSSAEYKKEIEELKE 305
            +  LA  Y  +++E     SKS EV    +  M  + +++K+ E  +  Y+   E   +
Sbjct: 383 LKQQLAL-YTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNK 441

Query: 306 LLPEIREK 313
            L E+ E+
Sbjct: 442 ALLEMAEE 449


>gi|4503509 eukaryotic translation initiation factor 3, subunit 10
           theta, 150/170kDa [Homo sapiens]
          Length = 1382

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 55/229 (24%), Positives = 103/229 (44%), Gaps = 30/229 (13%)

Query: 118 EEGEKTEDESLVENNDNIDETEGSEEDDKEND--KTEEMPNDSVL---------ENKSLQ 166
           +E E+ + +++ E  + I +TE   +  K+ D    EE+  D ++         E K LQ
Sbjct: 626 QEHEQIKKKTVRERLEQIKKTELGAKAFKDIDIEDLEELDPDFIMAKQVEQLEKEKKELQ 685

Query: 167 E---NEEEEIGNLELA--WDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQ 221
           E   N+E++I   E A   + + L K  ++ Q  K+  L+  Q   ++  + +E E   +
Sbjct: 686 ERLKNQEKKIDYFERAKRLEEIPLIKSAYEEQRIKDMDLWEQQEEERITTMQLERE---K 742

Query: 222 AVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSI-EVIENRMA 280
           A+E      N   + LE  D  +      + L     S Y+E + QF + + E   NR+ 
Sbjct: 743 ALEH----KNRMSRMLEDRDLFV------MRLKAARQSVYEEKLKQFEERLAEERHNRLE 792

Query: 281 VLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAEL 329
               Q KE    +   +KE EE +    ++ ++ E+ + ++R+    EL
Sbjct: 793 ERKRQRKEERRITYYREKEEEEQRRAEEQMLKEREERERAERAKREEEL 841


>gi|63252906 tropomyosin 1 alpha chain isoform 7 [Homo sapiens]
          Length = 284

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 57/238 (23%), Positives = 101/238 (42%), Gaps = 38/238 (15%)

Query: 95  LLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENN-DNIDETEGS-----EEDDKEN 148
           L EL + E+ +L         E +         LVE   D   E   +     EE +K  
Sbjct: 61  LEELHKAEDSLLAAEEAAAKAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAA 120

Query: 149 DKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLK 208
           D++E      V+E+++ ++ E+ EI  ++L                 KEA+  A  A  K
Sbjct: 121 DESER--GMKVIESRAQKDEEKMEIQEIQL-----------------KEAKHIAEDADRK 161

Query: 209 LGEVS---VESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAV 265
             EV+   V  E+ ++  EE       Q + LE   R++ +T   L  A    SQ ++  
Sbjct: 162 YEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRY 221

Query: 266 AQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRS 323
                     E  + VL++++KEAE  +   ++ + +L++ + ++ EK+  AKE   S
Sbjct: 222 ----------EEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEEKVAHAKEENLS 269


>gi|63252896 tropomyosin 1 alpha chain isoform 3 [Homo sapiens]
          Length = 284

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 41/182 (22%), Positives = 82/182 (45%), Gaps = 26/182 (14%)

Query: 142 EEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLY 201
           EE +K  D++E      V+E+++ ++ E+ EI  ++L                 KEA+  
Sbjct: 114 EEAEKAADESER--GMKVIESRAQKDEEKMEIQEIQL-----------------KEAKHI 154

Query: 202 AAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQY 261
           A  A  K  EV+       + +   +S L   E+  E  +   AE   +L          
Sbjct: 155 AEDADRKYEEVA-------RKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSL 207

Query: 262 DEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQ 321
           +    ++S+  +  E  + VL++++KEAE  +   ++ + +L++ + ++ EK+  AKE  
Sbjct: 208 EAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEEKVAHAKEEN 267

Query: 322 RS 323
            S
Sbjct: 268 LS 269



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 40/213 (18%), Positives = 90/213 (42%), Gaps = 15/213 (7%)

Query: 129 VENNDNIDETEGSEEDDKE-NDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAK 187
           ++  + +D  E +E D K   D+++++ ++ V   K L+  E+E     E   D  +  +
Sbjct: 13  LDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLE 72

Query: 188 IIFKRQETKEAQLYAAQAHLKLGEVSVES------------ENYVQAVEEFQSCLNLQEQ 235
           +  K+    EA + +    ++L E  ++             E   +A +E +  + + E 
Sbjct: 73  LAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIES 132

Query: 236 YLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAE 295
             +  +  +     QL  A       D    + ++ + +IE+ +    E+ + +EG  AE
Sbjct: 133 RAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAE 192

Query: 296 YKKEIEELKELLPEIREKIEDAKESQRSGNVAE 328
            ++E++ +   L  +  + E  K SQ+     E
Sbjct: 193 LEEELKTVTNNLKSLEAQAE--KYSQKEDRYEE 223


>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
          Length = 2400

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 77/354 (21%), Positives = 136/354 (38%), Gaps = 27/354 (7%)

Query: 111  EGVHVEEEEGE---KTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSLQE 167
            EG+   E EGE   ++E     E   +  E EG  + + E+ +  E   ++        +
Sbjct: 1833 EGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEA--------Q 1884

Query: 168  NEEEEIGNLELAWDMLDLAKIIFKRQETKEAQ--LYAAQAHLKLGEVSVESE-----NYV 220
             E E++   E  W++   ++     +  KEAQ    + +A    GE   ESE        
Sbjct: 1885 PESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAE 1944

Query: 221  QAVEEFQSCLNLQEQYL---EAHDRLLAETHYQLGLAYGYNSQYDEAVAQ-FSKSIEV-- 274
            +A +E +     + + +   EA +    E+     L     +Q  E  AQ  S+ +E   
Sbjct: 1945 EAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPE 2004

Query: 275  IENRMAVLNEQVK-EAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKA 333
             E  M    E+ + E++G  A+ K E EE +E+  E ++   DA+         E   +A
Sbjct: 2005 AEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEA 2064

Query: 334  TLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKD-D 392
               E             S  + A     +    S  V         ++    E+P  + +
Sbjct: 2065 QEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGE 2124

Query: 393  AKKAKQEPEVNGGSGDAVPSGNEV-SENMEEEAENQAESRAAVEGTVEAGATVE 445
            A+   +  E     G+A P    V +++ E EA+ ++E   A E   EA   +E
Sbjct: 2125 AQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELE 2178



 Score = 31.6 bits (70), Expect = 1.5
 Identities = 72/340 (21%), Positives = 120/340 (35%), Gaps = 55/340 (16%)

Query: 110  LEGVHVEEEEGEKTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSLQENE 169
            +E    EEE   ++ED   +E      E EG  + + E+ +  E       E +  +E  
Sbjct: 1961 IESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEG----EMQEAEEEA 2016

Query: 170  EEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENY--VQAVEEFQ 227
            + E   +E              + E +EAQ    +     G+   ES+     +A EE Q
Sbjct: 2017 QPESDGVEAQ-----------PKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQ 2065

Query: 228  SCL-NLQEQYLEAH------DRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMA 280
                 +QE   EAH      D   AE   Q   + G  +   E  AQ ++ IE  E    
Sbjct: 2066 EAEGEVQEAEGEAHPESEDVDAQEAEGEAQ-PESEGVEAPEAEGEAQKAEGIEAPETEGE 2124

Query: 281  VLNE----QVKEAEGSSAEYKKEIE---------------ELKELLPEIREKIE--DAKE 319
               E    +  EAEG +    + +E               E +E   E + ++E  +A E
Sbjct: 2125 AQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPE 2184

Query: 320  SQRSGNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRK 379
            ++         ++A   E        G         A  +P +G  +             
Sbjct: 2185 AEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEP-EGVETPE--------AEG 2235

Query: 380  KRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSEN 419
            + +PE E   + + K + Q    +G S +A  S + V E+
Sbjct: 2236 EAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPED 2275



 Score = 30.0 bits (66), Expect = 4.4
 Identities = 26/100 (26%), Positives = 42/100 (42%), Gaps = 18/100 (18%)

Query: 134  NIDETEGSEEDDKENDKTEEMPNDSVLENKSLQENEE--------EEIGNLELAWDMLDL 185
            N DE E   E+ + +   E++  ++V E   L+E +E        EE   LE       L
Sbjct: 1272 NEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGL 1331

Query: 186  AKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEE 225
             +   + +ETKE +          GE   E E  ++ +EE
Sbjct: 1332 QEEGVQLEETKETE----------GEGQQEEEAQLEEIEE 1361


>gi|221219020 NYD-SP11 protein [Homo sapiens]
          Length = 2873

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 47/239 (19%), Positives = 101/239 (42%), Gaps = 32/239 (13%)

Query: 108  NALEGVHVEEEEGEKTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSLQE 167
            N  EG  VEE++    E+E+L    + + E E     ++E    E+   + + ++K    
Sbjct: 1736 NQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEK---EKLAQHKEKMP 1792

Query: 168  NEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEF- 226
             EEE +G                KR++  E ++  AQ          + E ++ ++EE  
Sbjct: 1793 EEEERLGR---------------KREQLIEKKMKLAQ----------KRERWINSMEELT 1827

Query: 227  -QSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQ 285
                +  Q++ L    + LA+   +L           E +    K +  ++N++ + N+ 
Sbjct: 1828 KNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKI 1887

Query: 286  VKEAEGSSAEYKKEIEELKELLPEIREKIEDAKES--QRSGNVAELALKATLVESSTSG 342
            + + E    + K+ + + KE L E  +K+   ++S  ++   +A+  +K  L ++   G
Sbjct: 1888 LAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQG 1946



 Score = 38.9 bits (89), Expect = 0.010
 Identities = 50/208 (24%), Positives = 92/208 (44%), Gaps = 12/208 (5%)

Query: 115  VEEEEGEKTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEE-EI 173
            VE EE    E ESL++  +  +     EE+++E +  EE   + V E +  ++ EEE E 
Sbjct: 2220 VESEEHFSEEMESLLDELEKQESLSSEEEEEREEE--EEREEEEVREEEEERKEEEEGEE 2277

Query: 174  GNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQ 233
              +E   +     K   K++E +E +    +    + E   E+E+     EE +SC +L+
Sbjct: 2278 KQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSE--EETESLSDEEEEEESC-SLE 2334

Query: 234  EQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIEN---RMAVLNEQVKEAE 290
            E+     + L  E  ++L      + +  E V    + +   +    R+ VL   +K+  
Sbjct: 2335 EEVDREKEILKKEKQFKLQEQRRKSLRGRERVLSILRGVPHGKGRAIRLGVLKSPLKKLM 2394

Query: 291  GSSAEYKKEIEELKELLPEIREKIEDAK 318
             ++ E K   E+    +PE +   ED K
Sbjct: 2395 STALEMK---EKTPVPVPEKQISWEDKK 2419



 Score = 34.7 bits (78), Expect = 0.18
 Identities = 51/238 (21%), Positives = 99/238 (41%), Gaps = 55/238 (23%)

Query: 117  EEEGEKT---EDESLVENNDNIDETEGSEEDDKENDKTEEMPN--DSVLENKSLQENEEE 171
            +EE EK    E+E L +  + +   E   ++DK+  K EE     +++L +KS ++  ++
Sbjct: 1482 KEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKL-KWEEWKQVWENMLSSKSKEQQYKD 1540

Query: 172  EIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHL----KLGEVSVESENYVQAVEEFQ 227
            E        + + L + + +  E KE Q+   Q H+    K   +  +     +   + +
Sbjct: 1541 E--------EEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEE 1592

Query: 228  SCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVK 287
              L  +E+ L   +R LA+   +L  AY   +Q D  +AQ                    
Sbjct: 1593 RKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQ-------------------- 1632

Query: 288  EAEGSSAEYKKEIEELKELLPEIREKI----------------EDAKESQRSGNVAEL 329
             AEG  A+ ++ + +  E L +  EK+                E+ K +++ G +AE+
Sbjct: 1633 -AEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEV 1689



 Score = 33.1 bits (74), Expect = 0.53
 Identities = 45/203 (22%), Positives = 80/203 (39%), Gaps = 26/203 (12%)

Query: 117  EEEGEKTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNL 176
            E+  E T+DE  +         +     +KE   TEE    +   ++ + ++EEE  G +
Sbjct: 2127 EKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEE--GGI 2184

Query: 177  ELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQY 236
            E    +  L +   KR+E K                    E +   V+E +S    +E +
Sbjct: 2185 EEEEVIPFLKRRWRKRKEAKRGDK--------------PKEKFSSQVDEVES----EEHF 2226

Query: 237  LEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEY 296
             E  + LL E   Q  L+     + +E   +  + +   E       E+ +E EG   + 
Sbjct: 2227 SEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEE------ERKEEEEGEEKQV 2280

Query: 297  KKEIEELKELLPEIREKIEDAKE 319
            +KE EE K+   E +++    KE
Sbjct: 2281 EKEEEEKKKKKKEKKKEEVQEKE 2303



 Score = 32.3 bits (72), Expect = 0.90
 Identities = 30/100 (30%), Positives = 43/100 (43%), Gaps = 15/100 (15%)

Query: 111  EGVHVEEEEGEKTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKS------ 164
            E   V EEE E+ E+E   E     +E E  ++  KE  K E    + V E K       
Sbjct: 2258 EEEEVREEEEERKEEEEGEEKQVEKEEEE-KKKKKKEKKKEEVQEKEEVFEEKEEIMSEE 2316

Query: 165  -----LQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQ 199
                   E EEEE  +LE   + +D  K I K+++  + Q
Sbjct: 2317 ETESLSDEEEEEESCSLE---EEVDREKEILKKEKQFKLQ 2353



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 53/227 (23%), Positives = 96/227 (42%), Gaps = 24/227 (10%)

Query: 111  EGVHVEEE---EGEKTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSLQE 167
            E V +EEE   EGE+ E + + E   +I E        ++  + E+       E K  QE
Sbjct: 1542 EEVTLEEEVSREGEEKEQQ-VTEEQRHIQEEHKWARIHRKRARAEKKRAQE--ERKLAQE 1598

Query: 168  NEEEEIGNLELAWDMLDLA----KIIFKRQETKEAQLYAAQAHLKLGE----VSVESENY 219
             E+      +LA +   LA    KI    +E  +A+   AQ    L +    +S E+E  
Sbjct: 1599 EEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKL 1658

Query: 220  VQA----VEEFQSCLNLQEQYLEAHDRL------LAETHYQLGLAYGYNSQYDEAVAQFS 269
             Q      ++++     +E+  +   +L      LA+   +L          ++ +AQ  
Sbjct: 1659 AQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQEL 1718

Query: 270  KSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIED 316
            + +E     ++   E++ + EG   E KK++ E +E L   REK+ +
Sbjct: 1719 EELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSE 1765


>gi|63252900 tropomyosin 1 alpha chain isoform 4 [Homo sapiens]
          Length = 284

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 46/185 (24%), Positives = 85/185 (45%), Gaps = 32/185 (17%)

Query: 142 EEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLY 201
           EE +K  D++E      V+E+++ ++ E+ EI  ++L                 KEA+  
Sbjct: 114 EEAEKAADESER--GMKVIESRAQKDEEKMEIQEIQL-----------------KEAKHI 154

Query: 202 AAQAHLKLGEVS---VESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYN 258
           A  A  K  EV+   V  E+ ++  EE       Q + LE   R++ +T   L  A    
Sbjct: 155 AEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKY 214

Query: 259 SQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAK 318
           SQ ++            E  + VL++++KEAE  +   ++ + +L++ + ++ EK+  AK
Sbjct: 215 SQKEDRY----------EEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEEKVAHAK 264

Query: 319 ESQRS 323
           E   S
Sbjct: 265 EENLS 269



 Score = 35.0 bits (79), Expect = 0.14
 Identities = 40/214 (18%), Positives = 89/214 (41%), Gaps = 26/214 (12%)

Query: 129 VENNDNIDETEGSEEDDKE-NDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAK 187
           ++  + +D  E +E D K   D+++++ ++ V   K L+  E+E     E   D  +  +
Sbjct: 13  LDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLE 72

Query: 188 IIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAET 247
           +  K+    EA + +    ++L E  ++     +A E   + L   E+  +A D      
Sbjct: 73  LAEKKATDAEADVASLNRRIQLVEEELD-----RAQERLATALQKLEEAEKAAD------ 121

Query: 248 HYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELL 307
                       + +  +       +  E +M +   Q+KEA+  + +  ++ EE+   L
Sbjct: 122 ------------ESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKL 169

Query: 308 PEIREKIEDAKESQR--SGNVAELALKATLVESS 339
             I   +E A+E      G V +L  +  +++ +
Sbjct: 170 VIIESDLERAEERAELSEGQVRQLEEQLRIMDQT 203


>gi|194097392 Golgi autoantigen, golgin subfamily a, 2 [Homo
           sapiens]
          Length = 1002

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 55/234 (23%), Positives = 100/234 (42%), Gaps = 42/234 (17%)

Query: 115 VEEEEG----EKTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSLQENEE 170
           V++ EG     + ++E L+E  +   E  G E+ +      E M ND    +++L +N E
Sbjct: 487 VQDNEGLSRLNREQEERLLEL-ERAAELWG-EQAEARRQILETMQNDRTTISRALSQNRE 544

Query: 171 --EEIGNLE-----LAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAV 223
             E++  L+     L  + +++   +   Q  K       +   KLGE+  +     + V
Sbjct: 545 LKEQLAELQSGFVKLTNENMEITSALQSEQHVKR------ELGKKLGELQEKLSELKETV 598

Query: 224 E----EFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRM 279
           E    E QS    ++QYL                  G+  QY  A  Q +   EV+ N++
Sbjct: 599 ELKSQEAQSLQQQRDQYL------------------GHLQQYVAAYQQLTSEKEVLHNQL 640

Query: 280 AVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKA 333
            +  + V + +   A+ K   E  ++ L E +E++E A + Q     A+L+L A
Sbjct: 641 LLQTQLVDQLQQQEAQGKAVAEMARQELQETQERLEAATQ-QNQQLRAQLSLMA 693



 Score = 38.1 bits (87), Expect = 0.016
 Identities = 78/333 (23%), Positives = 138/333 (41%), Gaps = 53/333 (15%)

Query: 92  GKSLLELARMENGVLGNALEGVHVEEEEGEKTEDE-SLVENNDNIDETEGSEEDDKENDK 150
           GK++ E+AR E   L    E +    ++ ++   + SL+ +    D  +  EE+D+E ++
Sbjct: 657 GKAVAEMARQE---LQETQERLEAATQQNQQLRAQLSLMAHPGEGDGLDREEEEDEEEEE 713

Query: 151 TEEM----PNDSVLE------------NKSLQENEEEEI---GNL-ELAWDMLDLAKIIF 190
            E +    P  S+ E            N ++   EEE+    G L E       LA ++ 
Sbjct: 714 EEAVAVPQPMPSIPEDLESREAMVAFFNSAVASAEEEQARLRGQLKEQRVRCRRLAHLLA 773

Query: 191 KRQETKEAQLYAAQAHLKLGE-VSVESENYVQ-AVEEFQS-CLNLQEQYLEAHDRLLAET 247
             Q+  EA   AA A    G+ V  E+   +Q A+E+ QS  + L ++  +  +R+    
Sbjct: 774 SAQKEPEA---AAPAPGTGGDSVCGETHRALQGAMEKLQSRFMELMQEKADLKERVEELE 830

Query: 248 HYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELL 307
           H  + L+ G      E +A +       +++ AVL E+ +E E   +   ++ EE+K  L
Sbjct: 831 HRCIQLS-GETDTIGEYIALY-------QSQRAVLKERHREKEEYISRLAQDKEEMKVKL 882

Query: 308 PEIREKIEDAKESQRSGNVAELALKATLVESSTSG---------FTPGGGGSSVSMIASR 358
            E++E +      +   +   LA      +  TSG             G    VS+  S 
Sbjct: 883 LELQELVLRLVGDRNEWHGRFLAAAQNPADEPTSGAPAPQELGAANQQGDLCEVSLAGSV 942

Query: 359 KPTDGASSSNCVTD------ISHLVRKKRKPEE 385
           +P  G +      D      I  L+R+ + P E
Sbjct: 943 EPAQGEAREGSPRDNPTAQQIMQLLREMQNPRE 975


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 48/237 (20%), Positives = 102/237 (43%), Gaps = 19/237 (8%)

Query: 108  NALEGVHVEEEEGEKTEDESLVENNDNIDETEGSEEDDKEN-DKTEEMPNDSVLENKSLQ 166
            N+L+    EEEE  K  ++ ++     + +T+   +DD    +  EE     + + ++L 
Sbjct: 1346 NSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALS 1405

Query: 167  ENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEF 226
            +  EE+     LA+D L+  K   + QE  +  +           +  + + + Q + E 
Sbjct: 1406 QRLEEKA----LAYDKLEKTKNRLQ-QELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEE 1460

Query: 227  QSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVA----------QFSKSIEVIE 276
            +S   +  +Y E  DR  AE   +   A       +EA+           Q    +E + 
Sbjct: 1461 KS---ISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLM 1517

Query: 277  NRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKA 333
            +    + + V E E S    ++++EE++  L E+ ++++  ++++    V   A+KA
Sbjct: 1518 SSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKA 1574



 Score = 38.9 bits (89), Expect = 0.010
 Identities = 45/244 (18%), Positives = 109/244 (44%), Gaps = 29/244 (11%)

Query: 116  EEEEGEKTEDESLVENNDNIDETEGSEE--DDKENDKTEEMPNDS-----VLENK----- 163
            E E+  K+ +  +++  + +  +E +    + + ++  +E+ N +     +L+ K     
Sbjct: 1677 ESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEA 1736

Query: 164  ---SLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYV 220
                L+E  EEE  N+EL  D      +   + +T  A+L A ++       + +S+N  
Sbjct: 1737 RIAQLEEELEEEQSNMELLNDRFRKTTL---QVDTLNAELAAERS------AAQKSDNAR 1787

Query: 221  QAVEEFQSCLNLQEQYLEAHDR-----LLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVI 275
            Q +E     L  + Q LE   +      ++    ++G       Q  +  A  +K +   
Sbjct: 1788 QQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRT 1847

Query: 276  ENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATL 335
            E ++  +  QV++    + +YK+++E+    + +++ ++E+A+E     N +   L+  L
Sbjct: 1848 EKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQREL 1907

Query: 336  VESS 339
             +++
Sbjct: 1908 DDAT 1911



 Score = 36.2 bits (82), Expect = 0.062
 Identities = 47/233 (20%), Positives = 91/233 (39%), Gaps = 21/233 (9%)

Query: 106  LGNALEGVHVEEEEGEKTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSL 165
            L  ALE     +EE E+   +   +  D +   +   ++  E +K++      V E ++ 
Sbjct: 1488 LARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQ 1547

Query: 166  QENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEE 225
             E  E+E+   E A   L++     K Q  ++ Q    Q                   EE
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQN------------------EE 1589

Query: 226  FQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQ 285
             +  L  Q + LEA    L +   Q  LA     + +  +      IE        + +Q
Sbjct: 1590 KKRLLIKQVRELEAE---LEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQ 1646

Query: 286  VKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVES 338
            +++ +    +Y++E+EE +    EI  + +++++  +S     L L+  L  S
Sbjct: 1647 LRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASS 1699



 Score = 33.1 bits (74), Expect = 0.53
 Identities = 69/352 (19%), Positives = 135/352 (38%), Gaps = 40/352 (11%)

Query: 93   KSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDETEGSEEDDKENDKTE 152
            K  LE    E       L+ V  E E   K  D  + E +  +  +EG     +  +K  
Sbjct: 1226 KQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKV--SEGDRLRVELAEKAS 1283

Query: 153  EMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQET-KEAQLYAAQAHLKLGE 211
            ++ N+  L+N S    E E+ G ++ A D   L   +   QE  +E          ++ +
Sbjct: 1284 KLQNE--LDNVSTLLEEAEKKG-IKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQ 1340

Query: 212  VSVESENYV-QAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSK 270
            +  E  +   Q  EE ++  NL++Q L    +L A+T  ++    G     +EA  +  K
Sbjct: 1341 LEEEKNSLQEQQEEEEEARKNLEKQVLALQSQL-ADTKKKVDDDLGTIESLEEAKKKLLK 1399

Query: 271  SIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGN---VA 327
              E +  R+        + E +    ++E+++L   L   R+   + ++ Q+  +     
Sbjct: 1400 DAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAE 1459

Query: 328  ELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEES 387
            E ++ A   E                    R   +          ++  + +  + +EE 
Sbjct: 1460 EKSISARYAEE-----------------RDRAEAEAREKETKALSLARALEEALEAKEEF 1502

Query: 388  PRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVE 439
             R++   +A  E        D + S ++V +N+ E      +S+ A+E  VE
Sbjct: 1503 ERQNKQLRADME--------DLMSSKDDVGKNVHE----LEKSKRALEQQVE 1542



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 19/87 (21%), Positives = 40/87 (45%)

Query: 233 QEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGS 292
           QE+ L+A D  L +   +     G   + +    Q  +   ++  ++    E   EAE  
Sbjct: 850 QEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEM 909

Query: 293 SAEYKKEIEELKELLPEIREKIEDAKE 319
            A    + +EL+E+L ++  ++E+ +E
Sbjct: 910 RARLAAKKQELEEILHDLESRVEEEEE 936


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 43/218 (19%), Positives = 97/218 (44%), Gaps = 27/218 (12%)

Query: 108  NALEGVHVEEEEGEKTEDESLVENNDNIDETEG--SEEDDKENDKTEEMPNDSVLENKSL 165
            +AL+   ++ +E  +     L E  + ID+  G  SE+ DK ++  +++ N +    + +
Sbjct: 1763 DALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKI 1822

Query: 166  QENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAV-- 223
            QE +  E   + L  D+ +  K + + ++ K+         L L ++ +E+ N  Q +  
Sbjct: 1823 QELKANEHQLITLKKDVNETQKKVSEMEQLKKQ---IKDQSLTLSKLEIENLNLAQKLHE 1879

Query: 224  --EEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAV 281
              EE +S +  ++      + L  E                    Q  +S++  + R   
Sbjct: 1880 NLEEMKSVMKERDNLRRVEETLKLERD------------------QLKESLQETKARDLE 1921

Query: 282  LNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKE 319
            + +++K A   S E+K+ +++L+E + E   +I D ++
Sbjct: 1922 IQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQK 1959



 Score = 38.1 bits (87), Expect = 0.016
 Identities = 48/236 (20%), Positives = 97/236 (41%), Gaps = 30/236 (12%)

Query: 114  HVEEE-EGEKTEDESLVENNDNI-----DETEGSEEDDKENDKTEEMPNDSVLENKSLQE 167
            H++E+ E +K   E++   N  +     +  E      KE D    +     +E   L+E
Sbjct: 1648 HLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKE 1707

Query: 168  NEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQ 227
            N  E I                  R   K+ +L     HLK  + +++    + + E+  
Sbjct: 1708 NLRETI-----------------TRDLEKQEELKIVHMHLKEHQETIDKLRGIVS-EKTN 1749

Query: 228  SCLNLQEQYLEAHDRLLAET---HYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNE 284
               N+Q+    ++D L A+      +L +A+ +  +  E +    K   ++  +   L+ 
Sbjct: 1750 EISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETI---DKLRGIVSEKTDKLSN 1806

Query: 285  QVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESST 340
              K+ E S+A+ +++I+ELK    ++    +D  E+Q+  +  E   K    +S T
Sbjct: 1807 MQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLT 1862



 Score = 35.8 bits (81), Expect = 0.081
 Identities = 38/231 (16%), Positives = 101/231 (43%), Gaps = 26/231 (11%)

Query: 116  EEEEGEKTEDESLVENNDNIDE--------TEGSEEDDKENDKTEEMPNDSVLENKSLQE 167
            +E +  KT  E+L   +D + E         + S+   +++   +E  N++      +++
Sbjct: 1349 KERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQ 1408

Query: 168  NEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQ 227
             + ++   L +  +ML L+K +              ++H ++  V+ E ++  +  E  Q
Sbjct: 1409 FKPKDSALLRIEIEMLGLSKRL-------------QESHDEMKSVAKEKDDLQRLQEVLQ 1455

Query: 228  SCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVK 287
            S  +  ++ ++       ET  +L +A+    + +E + +   ++   E  ++ + +Q++
Sbjct: 1456 SESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLE 1515

Query: 288  EAEGSSAEYKKEIEELKEL-----LPEIREKIEDAKESQRSGNVAELALKA 333
                      +EI E +E      + E++EK+ + K+ +      + AL++
Sbjct: 1516 AINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQS 1566



 Score = 35.4 bits (80), Expect = 0.11
 Identities = 45/239 (18%), Positives = 100/239 (41%), Gaps = 19/239 (7%)

Query: 111  EGVHVEEEEGEKTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSLQENEE 170
            E + +E ++ +    +++  N D  ++   + E  K++ +T       + E  S   + E
Sbjct: 939  ESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHME 998

Query: 171  EEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEE----- 225
            E  G  +  +    +   I K+Q+ +        A +K  E+  +       ++E     
Sbjct: 999  ENTGETKDEFQQKMVG--IDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQ 1056

Query: 226  --FQSCLNLQEQY---LEAHDRLLAETHYQLGLAYGYNSQYDEAVAQ-----FSKSIEVI 275
               +S +  +EQ    L+ +  +  E   +L L      +  E VAQ       K  E+ 
Sbjct: 1057 QMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELS 1116

Query: 276  E--NRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALK 332
               +R+A + E++KE      E ++++  ++E + E+++KI + +  +      EL L+
Sbjct: 1117 RTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLE 1175



 Score = 34.3 bits (77), Expect = 0.24
 Identities = 42/226 (18%), Positives = 91/226 (40%), Gaps = 18/226 (7%)

Query: 117 EEEGEKTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNL 176
           E EG+ T+ +   E N  ++E E   E+     + + +P++     K +Q+  EE    L
Sbjct: 717 ELEGKITDLQK--ELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEE----L 770

Query: 177 ELAWDMLDLAKIIFKRQETKEAQLYAAQAHL--KLGEVSVESENYVQAVEEFQSCLNLQE 234
            +     D    +F     KE+++      +     +++    NY    +EFQ+   L  
Sbjct: 771 HIITSEKDK---LFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHM 827

Query: 235 QYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSA 294
            + + +  +L E           + +      +F  S+  ++  ++   ++++E      
Sbjct: 828 DFEQKYKMVLEENERMNQEIVNLSKE----AQKFDSSLGALKTELSYKTQELQEKTREVQ 883

Query: 295 EYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESST 340
           E   E+E+LKE   ++  +    +  +R   +    L+ TL E  T
Sbjct: 884 ERLNEMEQLKE---QLENRDSTLQTVEREKTLITEKLQQTLEEVKT 926



 Score = 33.5 bits (75), Expect = 0.40
 Identities = 51/247 (20%), Positives = 106/247 (42%), Gaps = 41/247 (16%)

Query: 114  HVEEEEGEKTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLE---------NKS 164
            H+ E   +  E +S  E + N+ E + +E     ++  +  P DS L          +K 
Sbjct: 1371 HIRETLAKIQESQSKQEQSLNMKEKD-NETTKIVSEMEQFKPKDSALLRIEIEMLGLSKR 1429

Query: 165  LQENEEE------EIGNLELAWDML---------DLAKIIFKRQETKEAQLYAAQAHLKL 209
            LQE+ +E      E  +L+   ++L         ++ +I+ K  ET+E +L  A   LK 
Sbjct: 1430 LQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEE-ELKVAHCCLKE 1488

Query: 210  GEVSV--------ESENYVQAVEEFQSCLN------LQEQYLEAHDRLLAETHYQLGLAY 255
             E ++        E E  +  +++    +N      +QE Y E  ++   +   ++    
Sbjct: 1489 QEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIY-EKEEQFNIKQISEVQEKV 1547

Query: 256  GYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIE 315
                Q+ E       +++ IE++M  L  +++E++       KE EE+K +   ++ + +
Sbjct: 1548 NELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERD 1607

Query: 316  DAKESQR 322
              KE+ +
Sbjct: 1608 QLKENTK 1614



 Score = 31.6 bits (70), Expect = 1.5
 Identities = 32/189 (16%), Positives = 85/189 (44%), Gaps = 15/189 (7%)

Query: 116 EEEEGEKTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGN 175
           E+   EK E E  ++  +++DE E  E   K++ + + +   S L+N      +  E+ N
Sbjct: 515 EQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLV----KHAEVYN 570

Query: 176 LELAWDMLDLAKIIFKRQETKEAQLYAAQAHL---KLGEVSVESENYVQAVEEFQSCLNL 232
            +L  ++    +++      KE Q+   Q ++   KL  + ++    ++++E+ +     
Sbjct: 571 QDLENELSSKVELL----REKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQ---- 622

Query: 233 QEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGS 292
            +Q L   + +  +   +       N +  E + + + + + +EN + +   Q++  +  
Sbjct: 623 MKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKM 682

Query: 293 SAEYKKEIE 301
             + +KE++
Sbjct: 683 QVDLEKELQ 691


>gi|118498356 kinectin 1 isoform a [Homo sapiens]
          Length = 1357

 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 34/136 (25%), Positives = 65/136 (47%), Gaps = 7/136 (5%)

Query: 212  VSVESENYVQAVEEFQSCLNLQEQYLEAHDRL----LAETHY---QLGLAYGYNSQYDEA 264
            + +E E Y   + E +  L   ++ +E  +      + E+H    Q+  ++  + Q  E 
Sbjct: 1132 LQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELER 1191

Query: 265  VAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSG 324
            +   +K IE +      L  ++++AE   + Y  E+ ELK+LL E+++K++D+       
Sbjct: 1192 LRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQ 1251

Query: 325  NVAELALKATLVESST 340
            N     LKA L E+ T
Sbjct: 1252 NEELNLLKAQLNETLT 1267



 Score = 30.8 bits (68), Expect = 2.6
 Identities = 39/177 (22%), Positives = 77/177 (43%), Gaps = 27/177 (15%)

Query: 155  PNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQL----YAAQAHL--- 207
            P++ +L  K + E E+E  G     W+ LD  K   + Q  K   L    + A   L   
Sbjct: 993  PHEELL--KVISEREKEISG----LWNELDSLKDAVEHQRKKNNDLREKNWEAMEALAST 1046

Query: 208  ------KLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLG-LAYGYNSQ 260
                  K+ + S E +  V+AVE     L  +E   +   ++   ++   G   +G+  +
Sbjct: 1047 EKMLQDKVNKTSKERQQQVEAVE-----LEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKK 1101

Query: 261  YDEAVAQFSKS--IEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIE 315
              E +A  S S  ++V+E+++   +E     +    +YK  + E + +L +++  +E
Sbjct: 1102 AKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVE 1158


>gi|33620775 kinectin 1 isoform a [Homo sapiens]
          Length = 1357

 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 34/136 (25%), Positives = 65/136 (47%), Gaps = 7/136 (5%)

Query: 212  VSVESENYVQAVEEFQSCLNLQEQYLEAHDRL----LAETHY---QLGLAYGYNSQYDEA 264
            + +E E Y   + E +  L   ++ +E  +      + E+H    Q+  ++  + Q  E 
Sbjct: 1132 LQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELER 1191

Query: 265  VAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSG 324
            +   +K IE +      L  ++++AE   + Y  E+ ELK+LL E+++K++D+       
Sbjct: 1192 LRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQ 1251

Query: 325  NVAELALKATLVESST 340
            N     LKA L E+ T
Sbjct: 1252 NEELNLLKAQLNETLT 1267



 Score = 30.8 bits (68), Expect = 2.6
 Identities = 39/177 (22%), Positives = 77/177 (43%), Gaps = 27/177 (15%)

Query: 155  PNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQL----YAAQAHL--- 207
            P++ +L  K + E E+E  G     W+ LD  K   + Q  K   L    + A   L   
Sbjct: 993  PHEELL--KVISEREKEISG----LWNELDSLKDAVEHQRKKNNDLREKNWEAMEALAST 1046

Query: 208  ------KLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLG-LAYGYNSQ 260
                  K+ + S E +  V+AVE     L  +E   +   ++   ++   G   +G+  +
Sbjct: 1047 EKMLQDKVNKTSKERQQQVEAVE-----LEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKK 1101

Query: 261  YDEAVAQFSKS--IEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIE 315
              E +A  S S  ++V+E+++   +E     +    +YK  + E + +L +++  +E
Sbjct: 1102 AKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVE 1158


>gi|169210053 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 185

 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 23/65 (35%), Positives = 40/65 (61%), Gaps = 2/65 (3%)

Query: 108 NALEGVHVEEEEGEKTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSLQE 167
           +A +G+ VEEEE E+ E+E  VE  +  +E E  EE++++ ++ EE   +   E K ++E
Sbjct: 111 SAQQGLPVEEEEVEEEEEE--VEEEEKEEEKEEDEEEEEKEEEKEEDEEEEEKEGKKMEE 168

Query: 168 NEEEE 172
            + EE
Sbjct: 169 EKVEE 173



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 24/67 (35%), Positives = 36/67 (53%), Gaps = 2/67 (2%)

Query: 107 GNALEGVHVEEEEGEKTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSLQ 166
           G  +E   VEEEE E  E+E   E  +  DE E  +E++KE D+ EE      +E + ++
Sbjct: 115 GLPVEEEEVEEEEEEVEEEEKEEEKEE--DEEEEEKEEEKEEDEEEEEKEGKKMEEEKVE 172

Query: 167 ENEEEEI 173
           E  + EI
Sbjct: 173 EEIDTEI 179


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
            sapiens]
          Length = 1870

 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 50/242 (20%), Positives = 109/242 (45%), Gaps = 16/242 (6%)

Query: 93   KSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDETEGSEEDDKENDK-T 151
            +S L+   MEN  L   LE + +  +  E+ E E    N     ET   E+D K+ +K  
Sbjct: 783  ESELQDLEMENQTLQKNLEELKISSKRLEQLEKE----NKSLEQETSQLEKDKKQLEKEN 838

Query: 152  EEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFK------RQETKEAQLYAAQA 205
            + +   + +++ +L+EN  + IGNLE     L     I+K      ++  KE +    +A
Sbjct: 839  KRLRQQAEIKDTTLEENNVK-IGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRA 897

Query: 206  HLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQY---- 261
             + +  +    E+ V    + Q   N  E+     +++       L      + +Y    
Sbjct: 898  TIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLE 957

Query: 262  DEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQ 321
             +  +   KS+E+ E ++A L  +++E+   + + ++E++ +K+    ++++ ++ +  Q
Sbjct: 958  SKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQ 1017

Query: 322  RS 323
             S
Sbjct: 1018 SS 1019



 Score = 38.1 bits (87), Expect = 0.016
 Identities = 46/233 (19%), Positives = 94/233 (40%), Gaps = 30/233 (12%)

Query: 117 EEEGEKTEDESLVENNDNIDETEGSEEDDK-----ENDKTEEMPNDSVLENKSL--QENE 169
           E + ++ + E L+E N  ++  +    D+      E ++       S    KSL  + NE
Sbjct: 397 ERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNE 456

Query: 170 EEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGE--------VSVESENYVQ 221
                 L+L  +   L K + + + T ++    A   LK+ +        V +     VQ
Sbjct: 457 LTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQ 516

Query: 222 AVEEFQSCLNLQEQYLEAH-------DRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEV 274
             +  Q+C NL +  ++         + L   +  Q+ +    N   ++ V+   +  ++
Sbjct: 517 EKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQI 576

Query: 275 --------IENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKE 319
                   IE    +L+E +KE     ++ + E  ++K+ L   +EK E A+E
Sbjct: 577 SAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEE 629



 Score = 37.4 bits (85), Expect = 0.028
 Identities = 39/213 (18%), Positives = 96/213 (45%), Gaps = 26/213 (12%)

Query: 105 VLGNALEGVHVEEEEGEKTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKS 164
           +L + LEG     ++  + E E+L +    + + E   E D +  K EE+  +++    +
Sbjct: 362 MLEDQLEGTRARSDKLHELEKENL-QLKAKLHDME--MERDMDRKKIEELMEENMTLEMA 418

Query: 165 LQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQ--AHLKLGEVSVESENYVQA 222
            +++ +E   +L L W++  +++     +  +++  +        +L ++ +E+++  + 
Sbjct: 419 QKQSMDE---SLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKT 475

Query: 223 VEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVL 282
           VEE ++ ++  E    A   L  E   Q                + SK +E++EN +   
Sbjct: 476 VEELRTTVDSVEG--NASKILKMEKENQ----------------RLSKKVEILENEIVQE 517

Query: 283 NEQVKEAEGSSAEYKKEIEELKELLPEIREKIE 315
            + ++  +  S +  KE  +L++ +  +RE  E
Sbjct: 518 KQSLQNCQNLSKDLMKEKAQLEKTIETLRENSE 550



 Score = 36.2 bits (82), Expect = 0.062
 Identities = 48/215 (22%), Positives = 93/215 (43%), Gaps = 25/215 (11%)

Query: 136  DETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDML----DLAKIIFK 191
            + T  S+     N   + +   S LEN++    +E E  +L+  +D L    +  +++ +
Sbjct: 1110 NSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKERE--DLKSLYDSLIKDHEKLELLHE 1167

Query: 192  RQETKEAQLYAAQAHLKLGEVSVESEN------YVQAVEEFQSCLNLQEQYLEAHDRLLA 245
            RQ ++   L +    LK    ++E E+      Y Q +++     +L++      +++L 
Sbjct: 1168 RQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLL 1227

Query: 246  ET--HYQLGLAY----GYNSQYDEAVAQFSKSIEVIE----NRMAVLNEQVKEAEGSSAE 295
            E   H  +   Y    G N + +   +Q  K  EV++    N  ++LN    E     AE
Sbjct: 1228 ENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAE 1287

Query: 296  YKKEIEELKELLPEIREKIEDAKE--SQRSGNVAE 328
            + K ++E  + L     K+ +  E  SQ  GN+ E
Sbjct: 1288 FSK-LKEQYQQLDITSTKLNNQCELLSQLKGNLEE 1321



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 42/235 (17%), Positives = 98/235 (41%), Gaps = 22/235 (9%)

Query: 100  RMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSV 159
            R E   +    E +   ++E    +    +   DN  E E S+E  +E  K ++   +  
Sbjct: 993  RQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERE-SQETTRELLKVKDRLIEVE 1051

Query: 160  LENKSLQENEEE---EIGNLELAWDMLDLAKIIFKRQ-----------ETKEAQLYAAQA 205
              N +LQ  ++    ++  LE   + L    +  +RQ           +T+ A+L    +
Sbjct: 1052 RNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENS 1111

Query: 206  HLKLGEVSVESENYVQAVE------EFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNS 259
             L     S+ ++N    ++      E +S +  +E     +D L+ + H +L L +   +
Sbjct: 1112 TLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKD-HEKLELLHERQA 1170

Query: 260  QYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKI 314
               E++     +++     + V +  +++      + K ++E+L+++L   +EK+
Sbjct: 1171 SEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKM 1225


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.303    0.122    0.319 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,765,780
Number of Sequences: 37866
Number of extensions: 756274
Number of successful extensions: 10118
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 315
Number of HSP's successfully gapped in prelim test: 688
Number of HSP's that attempted gapping in prelim test: 5318
Number of HSP's gapped (non-prelim): 3924
length of query: 449
length of database: 18,247,518
effective HSP length: 106
effective length of query: 343
effective length of database: 14,233,722
effective search space: 4882166646
effective search space used: 4882166646
T: 11
A: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.8 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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