Search of human proteins with 26051271

Search of human proteins with 26051271

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|26051271 voltage-gated potassium channel, subfamily H,
member 2 isoform b [Homo sapiens]
         (888 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|26051271 voltage-gated potassium channel, subfamily H, member...  1798   0.0  
gi|4557729 voltage-gated potassium channel, subfamily H, member ...  1611   0.0  
gi|27886653 potassium voltage-gated channel, subfamily H, member...  1075   0.0  
gi|27886665 potassium voltage-gated channel, subfamily H, member...   930   0.0  
gi|26051273 voltage-gated potassium channel, subfamily H, member...   863   0.0  
gi|13540549 potassium voltage-gated channel, subfamily H, member...   803   0.0  
gi|27886651 potassium voltage-gated channel, subfamily H, member...   704   0.0  
gi|27886667 potassium voltage-gated channel, subfamily H, member...   426   e-119
gi|6912446 potassium voltage-gated channel, subfamily H, member ...   422   e-118
gi|4504831 potassium voltage-gated channel, subfamily H, member ...   419   e-117
gi|22024390 potassium voltage-gated channel, subfamily H, member...   414   e-115
gi|27886648 potassium voltage-gated channel, subfamily H, member...   414   e-115
gi|27886646 potassium voltage-gated channel, subfamily H, member...   409   e-114
gi|27437001 potassium voltage-gated channel, subfamily H, member...   408   e-113
gi|38569493 potassium voltage-gated channel, subfamily H (eag-re...   394   e-109
gi|38327037 hyperpolarization activated cyclic nucleotide-gated ...   154   3e-37
gi|4885407 hyperpolarization activated cyclic nucleotide-gated p...   152   1e-36
gi|156071470 hyperpolarization activated cyclic nucleotide-gated...   150   4e-36
gi|116325989 hyperpolarization activated cyclic nucleotide-gated...   149   1e-35
gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2 [...   138   3e-32
gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Ho...   138   3e-32
gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1 [...   130   4e-30
gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [H...   130   4e-30
gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]    121   3e-27
gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]    117   4e-26
gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]     89   2e-17
gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [H...    85   3e-16
gi|195947369 junction-mediating and regulatory protein [Homo sap...    42   0.003
gi|205361107 potassium channel, subfamily K, member 17 isoform 2...    41   0.004
gi|17025230 potassium channel, subfamily K, member 17 isoform 1 ...    41   0.004

>gi|26051271 voltage-gated potassium channel, subfamily H, member 2
           isoform b [Homo sapiens]
          Length = 888

 Score = 1798 bits (4658), Expect = 0.0
 Identities = 888/888 (100%), Positives = 888/888 (100%)

Query: 1   MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVM 60
           MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVM
Sbjct: 1   MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVM 60

Query: 61  QRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDG 120
           QRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDG
Sbjct: 61  QRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDG 120

Query: 121 AVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSV 180
           AVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSV
Sbjct: 121 AVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSV 180

Query: 181 RSGGAGGAGAPGAVVVDVDLTPAAPSSESLALDEVTAMDNHVAGLGPAEERRALVGPGSP 240
           RSGGAGGAGAPGAVVVDVDLTPAAPSSESLALDEVTAMDNHVAGLGPAEERRALVGPGSP
Sbjct: 181 RSGGAGGAGAPGAVVVDVDLTPAAPSSESLALDEVTAMDNHVAGLGPAEERRALVGPGSP 240

Query: 241 PRSAPGQLPSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGVLPPPP 300
           PRSAPGQLPSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGVLPPPP
Sbjct: 241 PRSAPGQLPSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGVLPPPP 300

Query: 301 RHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIA 360
           RHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIA
Sbjct: 301 RHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIA 360

Query: 361 PKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIY 420
           PKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIY
Sbjct: 361 PKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIY 420

Query: 421 TAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANE 480
           TAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANE
Sbjct: 421 TAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANE 480

Query: 481 EVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLD 540
           EVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLD
Sbjct: 481 EVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLD 540

Query: 541 RYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSS 600
           RYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSS
Sbjct: 541 RYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSS 600

Query: 601 GLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVS 660
           GLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVS
Sbjct: 601 GLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVS 660

Query: 661 AIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGF 720
           AIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGF
Sbjct: 661 AIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGF 720

Query: 721 PECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALY 780
           PECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALY
Sbjct: 721 PECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALY 780

Query: 781 FISRGSIEILRGDVVVAILGMGWGAGTGLEMPSAASRGASLLNMQSLGLWTWDCLQGHWA 840
           FISRGSIEILRGDVVVAILGMGWGAGTGLEMPSAASRGASLLNMQSLGLWTWDCLQGHWA
Sbjct: 781 FISRGSIEILRGDVVVAILGMGWGAGTGLEMPSAASRGASLLNMQSLGLWTWDCLQGHWA 840

Query: 841 PLIHLNSGPPSGAMERSPTWGEAAELWGSHILLPFRIRHKQTLFASLK 888
           PLIHLNSGPPSGAMERSPTWGEAAELWGSHILLPFRIRHKQTLFASLK
Sbjct: 841 PLIHLNSGPPSGAMERSPTWGEAAELWGSHILLPFRIRHKQTLFASLK 888


>gi|4557729 voltage-gated potassium channel, subfamily H, member 2
           isoform a [Homo sapiens]
          Length = 1159

 Score = 1611 bits (4172), Expect = 0.0
 Identities = 800/800 (100%), Positives = 800/800 (100%)

Query: 1   MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVM 60
           MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVM
Sbjct: 1   MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVM 60

Query: 61  QRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDG 120
           QRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDG
Sbjct: 61  QRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDG 120

Query: 121 AVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSV 180
           AVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSV
Sbjct: 121 AVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSV 180

Query: 181 RSGGAGGAGAPGAVVVDVDLTPAAPSSESLALDEVTAMDNHVAGLGPAEERRALVGPGSP 240
           RSGGAGGAGAPGAVVVDVDLTPAAPSSESLALDEVTAMDNHVAGLGPAEERRALVGPGSP
Sbjct: 181 RSGGAGGAGAPGAVVVDVDLTPAAPSSESLALDEVTAMDNHVAGLGPAEERRALVGPGSP 240

Query: 241 PRSAPGQLPSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGVLPPPP 300
           PRSAPGQLPSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGVLPPPP
Sbjct: 241 PRSAPGQLPSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGVLPPPP 300

Query: 301 RHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIA 360
           RHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIA
Sbjct: 301 RHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIA 360

Query: 361 PKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIY 420
           PKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIY
Sbjct: 361 PKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIY 420

Query: 421 TAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANE 480
           TAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANE
Sbjct: 421 TAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANE 480

Query: 481 EVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLD 540
           EVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLD
Sbjct: 481 EVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLD 540

Query: 541 RYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSS 600
           RYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSS
Sbjct: 541 RYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSS 600

Query: 601 GLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVS 660
           GLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVS
Sbjct: 601 GLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVS 660

Query: 661 AIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGF 720
           AIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGF
Sbjct: 661 AIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGF 720

Query: 721 PECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALY 780
           PECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALY
Sbjct: 721 PECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALY 780

Query: 781 FISRGSIEILRGDVVVAILG 800
           FISRGSIEILRGDVVVAILG
Sbjct: 781 FISRGSIEILRGDVVVAILG 800


>gi|27886653 potassium voltage-gated channel, subfamily H, member 7
           isoform 1 [Homo sapiens]
          Length = 1196

 Score = 1075 bits (2780), Expect = 0.0
 Identities = 563/821 (68%), Positives = 645/821 (78%), Gaps = 39/821 (4%)

Query: 1   MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVM 60
           MPVRRGHVAPQNTFL TIIRKFEGQ++KFIIANARV+NCA+IYCNDGFCE+ G+SR +VM
Sbjct: 1   MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVM 60

Query: 61  QRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDG 120
           Q+PCTCDFLHGP T+R   AQIAQALLG+EERKVE+ +Y K+GS F+C   ++PVKN++G
Sbjct: 61  QKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEG 120

Query: 121 AVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSV 180
             +MFI+NFE V + +   +P      R  P   +     K F  K P L  LT R+ S+
Sbjct: 121 VAMMFIINFEYVTDNENAATP-----ERVNPILPIKTVNRKFFGFKFPGLRVLTYRKQSL 175

Query: 181 RSGGAGGAGAPGAVVVDVDLTPAAPSSESLALDEVTAMDNHVAGLGPAEERRALVGPG-- 238
                     P  VV+D     +  S +S+A+    +          A++ +AL+ P   
Sbjct: 176 PQED------PDVVVID----SSKHSDDSVAMKHFKSPTKESCSPSEADDTKALIQPSKC 225

Query: 239 SPPRSAPGQL----PSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAG 294
           SP  +  G L    P  +   L PD   SS  L+ +RSRES  S+RRASS  DIE    G
Sbjct: 226 SPLVNISGPLDHSSPKRQWDRLYPDMLQSSSQLSHSRSRESLCSIRRASSVHDIEGF--G 283

Query: 295 VLPPP---PRHAST-------GAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLK 344
           V P      RHAS        G  + ++S LL STSDS+L +Y TI+KIPQ+TLNF ++K
Sbjct: 284 VHPKNIFRDRHASEDNGRNVKGPFNHIKSSLLGSTSDSNLNKYSTINKIPQLTLNFSEVK 343

Query: 345 GDPFLASP-TSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHY 403
            +   +SP +SD+ IIAPK+K+RTHNVTEKVTQVLSLGADVLPEYKLQ PRI+++TILHY
Sbjct: 344 TEKKNSSPPSSDKTIIAPKVKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHY 403

Query: 404 SPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMF 463
           SPFKAVWDWLILLLVIYTA+FTPYSAAFLL + EE     ECGY+C PL VVDLIVDIMF
Sbjct: 404 SPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREE-QKRRECGYSCSPLNVVDLIVDIMF 462

Query: 464 IVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEE---L 520
           I+DILINFRTTYVN NEEVVS P +IA+HYFKGWFLIDMVAAIPFDLLIFGSGS+E   L
Sbjct: 463 IIDILINFRTTYVNQNEEVVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDETTTL 522

Query: 521 IGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMD 580
           IGLLKTARLLRLVRVARKLDRYSEYGAAVL LLMC FALIAHWLACIWYAIGN+E+P++ 
Sbjct: 523 IGLLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFALIAHWLACIWYAIGNVERPYLT 582

Query: 581 SRIGWLHNLGDQIGKPYNSS-GLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKI 639
            +IGWL +LG QIGK YN S    GPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKI
Sbjct: 583 DKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKI 642

Query: 640 FSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEE 699
           FSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYH QMLRV+EFIRFHQIPNPLRQRLEE
Sbjct: 643 FSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEE 702

Query: 700 YFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFK 759
           YFQHAW+YTNGIDMN VLKGFPECLQADICLHLN++LLQ+CK FRGA+KGCLRALAMKFK
Sbjct: 703 YFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFK 762

Query: 760 TTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILG 800
           TTHAPPGDTLVH GD+LTALYF+SRGSIEIL+ D+VVAILG
Sbjct: 763 TTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDDIVVAILG 803


>gi|27886665 potassium voltage-gated channel, subfamily H, member 7
           isoform 2 [Homo sapiens]
          Length = 732

 Score =  930 bits (2403), Expect = 0.0
 Identities = 490/730 (67%), Positives = 564/730 (77%), Gaps = 32/730 (4%)

Query: 1   MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVM 60
           MPVRRGHVAPQNTFL TIIRKFEGQ++KFIIANARV+NCA+IYCNDGFCE+ G+SR +VM
Sbjct: 1   MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVM 60

Query: 61  QRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDG 120
           Q+PCTCDFLHGP T+R   AQIAQALLG+EERKVE+ +Y K+GS F+C   ++PVKN++G
Sbjct: 61  QKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEG 120

Query: 121 AVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSV 180
             +MFI+NFE V + +   +P      R  P   +     K F  K P L  LT R+ S+
Sbjct: 121 VAMMFIINFEYVTDNENAATP-----ERVNPILPIKTVNRKFFGFKFPGLRVLTYRKQSL 175

Query: 181 RSGGAGGAGAPGAVVVDVDLTPAAPSSESLALDEVTAMDNHVAGLGPAEERRALVGPG-- 238
                     P  VV+D     +  S +S+A+    +          A++ +AL+ P   
Sbjct: 176 PQED------PDVVVID----SSKHSDDSVAMKHFKSPTKESCSPSEADDTKALIQPSKC 225

Query: 239 SPPRSAPGQL----PSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAG 294
           SP  +  G L    P  +   L PD   SS  L+ +RSRES  S+RRASS  DIE    G
Sbjct: 226 SPLVNISGPLDHSSPKRQWDRLYPDMLQSSSQLSHSRSRESLCSIRRASSVHDIEGF--G 283

Query: 295 VLPPP---PRHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLAS 351
           V P      RHAS G  + ++S LL STSDS+L +Y TI+KIPQ+TLNF ++K +   +S
Sbjct: 284 VHPKNIFRDRHASEGPFNHIKSSLLGSTSDSNLNKYSTINKIPQLTLNFSEVKTEKKNSS 343

Query: 352 P-TSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVW 410
           P +SD+ IIAPK+K+RTHNVTEKVTQVLSLGADVLPEYKLQ PRI+++TILHYSPFKAVW
Sbjct: 344 PPSSDKTIIAPKVKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVW 403

Query: 411 DWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILIN 470
           DWLILLLVIYTA+FTPYSAAFLL + EE     ECGY+C PL VVDLIVDIMFI+DILIN
Sbjct: 404 DWLILLLVIYTAIFTPYSAAFLLNDREE-QKRRECGYSCSPLNVVDLIVDIMFIIDILIN 462

Query: 471 FRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEE---LIGLLKTA 527
           FRTTYVN NEEVVS P +IA+HYFKGWFLIDMVAAIPFDLLIFGSGS+E   LIGLLKTA
Sbjct: 463 FRTTYVNQNEEVVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTA 522

Query: 528 RLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLH 587
           RLLRLVRVARKLDRYSEYGAAVL LLMC FALIAHWLACIWYAIGN+E+P++  +IGWL 
Sbjct: 523 RLLRLVRVARKLDRYSEYGAAVLMLLMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLD 582

Query: 588 NLGDQIGKPYNSS-GLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVML 646
           +LG QIGK YN S    GPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVML
Sbjct: 583 SLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVML 642

Query: 647 IGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWS 706
           IGSLMYASIFGNVSAIIQRLYSGTARYH QMLRV+EFIRFHQIPNPLRQRLEEYFQHAW+
Sbjct: 643 IGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWT 702

Query: 707 YTNGIDMNAV 716
           YTNGIDMN V
Sbjct: 703 YTNGIDMNMV 712


>gi|26051273 voltage-gated potassium channel, subfamily H, member 2
           isoform c [Homo sapiens]
          Length = 819

 Score =  863 bits (2231), Expect = 0.0
 Identities = 424/425 (99%), Positives = 425/425 (100%)

Query: 376 QVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKE 435
           +VLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKE
Sbjct: 36  EVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKE 95

Query: 436 TEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFK 495
           TEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFK
Sbjct: 96  TEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFK 155

Query: 496 GWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMC 555
           GWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMC
Sbjct: 156 GWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMC 215

Query: 556 TFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTAL 615
           TFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTAL
Sbjct: 216 TFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTAL 275

Query: 616 YFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHT 675
           YFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHT
Sbjct: 276 YFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHT 335

Query: 676 QMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRS 735
           QMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRS
Sbjct: 336 QMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRS 395

Query: 736 LLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVV 795
           LLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVV
Sbjct: 396 LLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVV 455

Query: 796 VAILG 800
           VAILG
Sbjct: 456 VAILG 460


>gi|13540549 potassium voltage-gated channel, subfamily H, member 6
           isoform 1 [Homo sapiens]
          Length = 994

 Score =  803 bits (2074), Expect = 0.0
 Identities = 402/480 (83%), Positives = 434/480 (90%), Gaps = 6/480 (1%)

Query: 326 RYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAP-KIKERTHNVTEKVTQVLSLGADV 384
           +YRTIS+IPQ TLNFV+   +   +S T++ EIIAP K+ ERT NVTEKVTQVLSLGADV
Sbjct: 174 KYRTISQIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADV 233

Query: 385 LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATE 444
           LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLL + +E      
Sbjct: 234 LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGA- 292

Query: 445 CGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVA 504
           C Y C PL VVDLIVDIMF+VDI+INFRTTYVN N+EVVSHP RIAVHYFKGWFLIDMVA
Sbjct: 293 CSYTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVA 352

Query: 505 AIPFDLLIFGSGSEE---LIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIA 561
           AIPFDLLIF +GS+E   LIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIA
Sbjct: 353 AIPFDLLIFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIA 412

Query: 562 HWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSG-LGGPSIKDKYVTALYFTFS 620
           HWLACIWYAIGN+E+P+++ +IGWL +LG Q+GK YN S    GPS++DKYVTALYFTFS
Sbjct: 413 HWLACIWYAIGNVERPYLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFS 472

Query: 621 SLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRV 680
           SLTSVGFGNVSPNTNSEK+FSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRV
Sbjct: 473 SLTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRV 532

Query: 681 REFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHC 740
           +EFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHL+R+LLQHC
Sbjct: 533 KEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHC 592

Query: 741 KPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILG 800
             F GA KGCLRALA+KFKTTHAPPGDTLVH GD+L+ LYFISRGSIEILR DVVVAILG
Sbjct: 593 PAFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILG 652



 Score =  224 bits (570), Expect = 4e-58
 Identities = 106/130 (81%), Positives = 117/130 (90%)

Query: 1   MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVM 60
           MPVRRGHVAPQNT+LDTIIRKFEGQSRKF+IANA++ENCA+IYCNDGFCEL GYSR EVM
Sbjct: 1   MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVM 60

Query: 61  QRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDG 120
           Q+PCTCDFL GP T   A +++AQALLGAEE KV+I +YRKD S F CLVDVVPVKNEDG
Sbjct: 61  QQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDG 120

Query: 121 AVIMFILNFE 130
           AVIMFILNFE
Sbjct: 121 AVIMFILNFE 130


>gi|27886651 potassium voltage-gated channel, subfamily H, member 6
           isoform 2 [Homo sapiens]
          Length = 905

 Score =  704 bits (1816), Expect = 0.0
 Identities = 367/479 (76%), Positives = 389/479 (81%), Gaps = 57/479 (11%)

Query: 326 RYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAP-KIKERTHNVTEKVTQVLSLGADV 384
           +YRTIS+IPQ TLNFV+   +   +S T++ EIIAP K+ ERT NVTEKVTQVLSLGADV
Sbjct: 174 KYRTISQIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADV 233

Query: 385 LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATE 444
           LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLL + +E      
Sbjct: 234 LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGA- 292

Query: 445 CGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVA 504
           C Y C PL VVDLIVDIMF+VDI+INFRTTYVN N+EVVSHP RIAVHYFKGWFLIDMVA
Sbjct: 293 CSYTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVA 352

Query: 505 AIPFDLLIFGSGSEE---LIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIA 561
           AIPFDLLIF +GS+E   LIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIA
Sbjct: 353 AIPFDLLIFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIA 412

Query: 562 HWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSS 621
           HWLACI                                                     S
Sbjct: 413 HWLACI----------------------------------------------------CS 420

Query: 622 LTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVR 681
           LTSVGFGNVSPNTNSEK+FSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRV+
Sbjct: 421 LTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVK 480

Query: 682 EFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCK 741
           EFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHL+R+LLQHC 
Sbjct: 481 EFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCP 540

Query: 742 PFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILG 800
            F GA KGCLRALA+KFKTTHAPPGDTLVH GD+L+ LYFISRGSIEILR DVVVAILG
Sbjct: 541 AFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILG 599



 Score =  224 bits (570), Expect = 4e-58
 Identities = 106/130 (81%), Positives = 117/130 (90%)

Query: 1   MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVM 60
           MPVRRGHVAPQNT+LDTIIRKFEGQSRKF+IANA++ENCA+IYCNDGFCEL GYSR EVM
Sbjct: 1   MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVM 60

Query: 61  QRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDG 120
           Q+PCTCDFL GP T   A +++AQALLGAEE KV+I +YRKD S F CLVDVVPVKNEDG
Sbjct: 61  QQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDG 120

Query: 121 AVIMFILNFE 130
           AVIMFILNFE
Sbjct: 121 AVIMFILNFE 130


>gi|27886667 potassium voltage-gated channel, subfamily H, member 8
           [Homo sapiens]
          Length = 1107

 Score =  426 bits (1096), Expect = e-119
 Identities = 216/444 (48%), Positives = 299/444 (67%), Gaps = 15/444 (3%)

Query: 373 KVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFL 432
           K+   + +     PEYK+   +  ++ +LH+S FKA WDWLILL   Y AV  PY+  F+
Sbjct: 187 KINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFI 246

Query: 433 LKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVH 492
             +      +T          V D+ V+I+FI+DI++NFRTTYV+ + +V+     I +H
Sbjct: 247 GNDDLSTTRST---------TVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIH 297

Query: 493 YFKGWFLIDMVAAIPFDLLI-FGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLF 551
           Y   WF+ID++AA+PFDLL  F      L+ LLKT RLLRL+R+ +KLDRYS++   VL 
Sbjct: 298 YVTTWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLT 357

Query: 552 LLMCTFALIAHWLACIWYAIGNMEQPH---MDSRIGWLHNLGDQIGKPY-NSSGLGGPSI 607
           LLM  FAL+AHW+ACIWY IG ME+     +   +GWLH LG ++  PY  ++ LGGPSI
Sbjct: 358 LLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSI 417

Query: 608 KDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLY 667
           +  Y+ ALYFT SSLTSVGFGNVS NT++EKIFSIC MLIG+LM+A +FGNV+AIIQR+Y
Sbjct: 418 RSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMY 477

Query: 668 SGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQAD 727
           S  + YHT+   +++FIR H +P  L+QR+ EYFQ  WS  NGID N +LK FP+ L++D
Sbjct: 478 SRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSD 537

Query: 728 ICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSI 787
           I +HLN+ +LQ    F  A++GCLR+L++  KT+   PG+ L+  GD L A+YF+  GS+
Sbjct: 538 ITMHLNKEILQ-LSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSM 596

Query: 788 EILRGDVVVAILGMGWGAGTGLEM 811
           E+L+  +V+AILG G   G  L +
Sbjct: 597 EVLKDSMVLAILGKGDLIGANLSI 620



 Score =  144 bits (362), Expect = 5e-34
 Identities = 68/142 (47%), Positives = 99/142 (69%), Gaps = 1/142 (0%)

Query: 1   MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARV-ENCAVIYCNDGFCELCGYSRAEV 59
           MPV +G +APQNTFLDTI  +F+G    FI+ANA+V +   ++YC+DGFCEL G++R EV
Sbjct: 1   MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEV 60

Query: 60  MQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNED 119
           MQ+ C+C FL G  T  +   QI ++L    E K EI FY+K+GS F CL+D+VP+KNE 
Sbjct: 61  MQKSCSCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEK 120

Query: 120 GAVIMFILNFEVVMEKDMVGSP 141
           G V++F+ +F+ + +  +  +P
Sbjct: 121 GDVVLFLASFKDITDTKVKITP 142


>gi|6912446 potassium voltage-gated channel, subfamily H, member 4
           [Homo sapiens]
          Length = 1017

 Score =  422 bits (1085), Expect = e-118
 Identities = 217/432 (50%), Positives = 295/432 (68%), Gaps = 13/432 (3%)

Query: 385 LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATE 444
           +PEYK+ +    R  +LHYS  KA+WD LILL   Y AV  PY+  F     ++  P T 
Sbjct: 204 VPEYKVASVGGSRCLLLHYSVSKAIWDGLILLATFYVAVTVPYNVCF---SGDDDTPITS 260

Query: 445 CGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVA 504
                +   V D+ V+++FI+DI++NFRTTYV+ + +V+S P  I +HY   WF ID++A
Sbjct: 261 -----RHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSIGLHYLATWFFIDLIA 315

Query: 505 AIPFDLL-IFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHW 563
           A+PFDLL IF      L+ LLKT RLLRL+R+ +KL+RYS+  A VL LLM  FAL+AHW
Sbjct: 316 ALPFDLLYIFNITVTSLVHLLKTVRLLRLLRLLQKLERYSQCSAVVLTLLMSVFALLAHW 375

Query: 564 LACIWYAIGNMEQPHMDSR---IGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFS 620
           +ACIWY IG  E    D     IGWLH LG ++  PY +  +GGPS +  Y+ ALYFT S
Sbjct: 376 MACIWYVIGRREMEANDPLLWDIGWLHELGKRLEVPYVNGSVGGPSRRSAYIAALYFTLS 435

Query: 621 SLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRV 680
           SLTSVGFGNV  NT++EKIFSIC MLIG+LM+A +FGNV+AIIQR+YS  + YH++M  +
Sbjct: 436 SLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDL 495

Query: 681 REFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHC 740
           ++FIR H++P PL+QR+ EYFQ  W+  +GID N +L+ FP+ L+ADI +HLNR +LQ  
Sbjct: 496 KDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREILQ-L 554

Query: 741 KPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILG 800
             F  A++GCLRAL++  KT+   PG+ L+  GD L A Y++  GS+E+LR ++V+AILG
Sbjct: 555 PLFGAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMVLAILG 614

Query: 801 MGWGAGTGLEMP 812
            G   G  +  P
Sbjct: 615 KGDLIGADIPEP 626



 Score =  154 bits (389), Expect = 3e-37
 Identities = 74/155 (47%), Positives = 104/155 (67%), Gaps = 11/155 (7%)

Query: 1   MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANAR-VENCAVIYCNDGFCELCGYSRAEV 59
           MPV +G +APQNTFLDTI  +F+G    F++ANA+      ++YC+DGFCEL GY R EV
Sbjct: 1   MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEV 60

Query: 60  MQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNED 119
           MQ+ C+C FL+GP T   A  ++ +AL G +E + EI FYRKDGS F CL+D++P+KNE 
Sbjct: 61  MQKTCSCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEM 120

Query: 120 GAVIMFILNFEVVMEKDMVGSPA-------HDTNH 147
           G V++F+ +F+ + +    GSP         D+NH
Sbjct: 121 GEVVLFLFSFKDITQS---GSPGLGPQGGRGDSNH 152


>gi|4504831 potassium voltage-gated channel, subfamily H, member 1
           isoform 2 [Homo sapiens]
          Length = 962

 Score =  419 bits (1076), Expect = e-117
 Identities = 213/469 (45%), Positives = 305/469 (65%), Gaps = 32/469 (6%)

Query: 353 TSDREII---APKIK--ERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFK 407
           TS R ++   AP ++  E  H  + ++ +VL LG+D+LP+YK +AP+     ILHY  FK
Sbjct: 159 TSSRGVLQQLAPSVQKGENVHKHS-RLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFK 217

Query: 408 AVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDI 467
             WDW+IL+L  YTA+  PY+ +F  ++                  VVD IVD++F+VDI
Sbjct: 218 TTWDWIILILTFYTAILVPYNVSFKTRQNNVA------------WLVVDSIVDVIFLVDI 265

Query: 468 LINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLI----FGSGSEELIGL 523
           ++NF TT+V    EV+S P  I ++Y K WF+ID+++ +P+D++        G   L   
Sbjct: 266 VLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEGISSLFSS 325

Query: 524 LKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRI 583
           LK  RLLRL RVARKLD Y EYGAAVL LL+C F L AHW+ACIWY+IG+ E    D++ 
Sbjct: 326 LKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKT 385

Query: 584 ----GWLHNLGDQIGKPYNSSGLG------GPSIKDKYVTALYFTFSSLTSVGFGNVSPN 633
                WL+ L   IG PY  +G G      GPS    Y+++LYFT +SLTSVGFGN++P+
Sbjct: 386 IRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPS 445

Query: 634 TNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPL 693
           T+ EKIF++ +M+IGSL+YA+IFGNV+ I Q++Y+ T RYH  +  VR+F++ +Q+P  L
Sbjct: 446 TDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGL 505

Query: 694 RQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRA 753
            +R+ +Y    WS + GID   VL+  P+ ++ADIC+HLNR + +    FR A+ GCLRA
Sbjct: 506 SERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRA 565

Query: 754 LAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGMG 802
           LAM+F+T H  PGD + HAG+ + +L F+  GS+E+++ D VVAILG G
Sbjct: 566 LAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKG 614



 Score =  106 bits (264), Expect = 1e-22
 Identities = 49/126 (38%), Positives = 75/126 (59%), Gaps = 2/126 (1%)

Query: 4   RRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRP 63
           RRG VAPQNTFL+ I+R+       F++ NA++ +  ++Y NDGFC+L GY RAEVMQ+ 
Sbjct: 7   RRGLVAPQNTFLENIVRR--SNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKS 64

Query: 64  CTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVI 123
            TC F++G  T +    ++ Q     E    EI  Y+K+ +     V + P++NE   V+
Sbjct: 65  STCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVV 124

Query: 124 MFILNF 129
           +F+  F
Sbjct: 125 LFLCTF 130


>gi|22024390 potassium voltage-gated channel, subfamily H, member 5
           isoform 1 [Homo sapiens]
          Length = 988

 Score =  414 bits (1063), Expect = e-115
 Identities = 209/467 (44%), Positives = 301/467 (64%), Gaps = 25/467 (5%)

Query: 349 LASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKA 408
           L +  S  + + P  K    +   ++ +VL LG+D+LP+YK +AP+     ILHY  FK 
Sbjct: 156 LTNSRSVLQQLTPMNKTEVVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKT 215

Query: 409 VWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDIL 468
            WDW+IL+L  YTA+  PY+ +F  K+                  V+D +VD++F+VDI+
Sbjct: 216 TWDWVILILTFYTAIMVPYNVSFKTKQNNIA------------WLVLDSVVDVIFLVDIV 263

Query: 469 INFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLI----FGSGSEELIGLL 524
           +NF TT+V    EV+S P  I ++Y K WF+ID+++ +P+D++        G   L   L
Sbjct: 264 LNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSL 323

Query: 525 KTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQ-PHMDSRI 583
           K  RLLRL RVARKLD Y EYGAAVL LL+C F L+AHWLACIWY+IG+ E    + + I
Sbjct: 324 KVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTI 383

Query: 584 ---GWLHNLGDQIGKPYN---SSGL--GGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTN 635
               WL+ L   IG PY    S+G+  GGPS    YV++LYFT +SLT++GFGN++P T+
Sbjct: 384 QIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTD 443

Query: 636 SEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQ 695
            EK+FS+ +M++GSL+YA+IFGNV+ I Q++Y+ T RYH  +  VR+F++ +Q+P  L +
Sbjct: 444 VEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSE 503

Query: 696 RLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALA 755
           R+ +Y    WS + GID   VL   P+ ++ADIC+HLNR +      FR A+ GCLRALA
Sbjct: 504 RVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALA 563

Query: 756 MKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGMG 802
           ++F+T H  PGD + HAG+ + AL F+  GS+E+++ D VVAILG G
Sbjct: 564 VEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKG 610



 Score =  103 bits (258), Expect = 5e-22
 Identities = 50/146 (34%), Positives = 85/146 (58%), Gaps = 5/146 (3%)

Query: 4   RRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRP 63
           +RG VAPQNTFL+ I+R+    S  F++ NA++ +  V+Y NDGFC+L GY RA+VMQ+ 
Sbjct: 5   KRGLVAPQNTFLENIVRRSSESS--FLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKS 62

Query: 64  CTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVI 123
            TC F++G  T ++   ++ Q     E    E+  Y+K+ +     + + P++NE   V+
Sbjct: 63  STCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVV 122

Query: 124 MFILNFEVVMEKDMVGSPAHDTNHRG 149
           +F+  F+ +    +   P  D + +G
Sbjct: 123 LFLCTFKDI---TLFKQPIEDDSTKG 145


>gi|27886648 potassium voltage-gated channel, subfamily H, member 5
           isoform 2 [Homo sapiens]
          Length = 624

 Score =  414 bits (1063), Expect = e-115
 Identities = 209/467 (44%), Positives = 301/467 (64%), Gaps = 25/467 (5%)

Query: 349 LASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKA 408
           L +  S  + + P  K    +   ++ +VL LG+D+LP+YK +AP+     ILHY  FK 
Sbjct: 98  LTNSRSVLQQLTPMNKTEVVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKT 157

Query: 409 VWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDIL 468
            WDW+IL+L  YTA+  PY+ +F  K+                  V+D +VD++F+VDI+
Sbjct: 158 TWDWVILILTFYTAIMVPYNVSFKTKQNNIA------------WLVLDSVVDVIFLVDIV 205

Query: 469 INFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLI----FGSGSEELIGLL 524
           +NF TT+V    EV+S P  I ++Y K WF+ID+++ +P+D++        G   L   L
Sbjct: 206 LNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSL 265

Query: 525 KTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQ-PHMDSRI 583
           K  RLLRL RVARKLD Y EYGAAVL LL+C F L+AHWLACIWY+IG+ E    + + I
Sbjct: 266 KVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTI 325

Query: 584 ---GWLHNLGDQIGKPYN---SSGL--GGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTN 635
               WL+ L   IG PY    S+G+  GGPS    YV++LYFT +SLT++GFGN++P T+
Sbjct: 326 QIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTD 385

Query: 636 SEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQ 695
            EK+FS+ +M++GSL+YA+IFGNV+ I Q++Y+ T RYH  +  VR+F++ +Q+P  L +
Sbjct: 386 VEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSE 445

Query: 696 RLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALA 755
           R+ +Y    WS + GID   VL   P+ ++ADIC+HLNR +      FR A+ GCLRALA
Sbjct: 446 RVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALA 505

Query: 756 MKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGMG 802
           ++F+T H  PGD + HAG+ + AL F+  GS+E+++ D VVAILG G
Sbjct: 506 VEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKG 552



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 21/90 (23%), Positives = 44/90 (48%), Gaps = 3/90 (3%)

Query: 60  MQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNED 119
           MQ+  TC F++G  T ++   ++ Q     E    E+  Y+K+ +     + + P++NE 
Sbjct: 1   MQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEH 60

Query: 120 GAVIMFILNFEVVMEKDMVGSPAHDTNHRG 149
             V++F+  F+ +    +   P  D + +G
Sbjct: 61  EKVVLFLCTFKDI---TLFKQPIEDDSTKG 87


>gi|27886646 potassium voltage-gated channel, subfamily H, member 5
           isoform 3 [Homo sapiens]
          Length = 611

 Score =  409 bits (1052), Expect = e-114
 Identities = 207/464 (44%), Positives = 299/464 (64%), Gaps = 25/464 (5%)

Query: 349 LASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKA 408
           L +  S  + + P  K    +   ++ +VL LG+D+LP+YK +AP+     ILHY  FK 
Sbjct: 156 LTNSRSVLQQLTPMNKTEVVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKT 215

Query: 409 VWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDIL 468
            WDW+IL+L  YTA+  PY+ +F  K+                  V+D +VD++F+VDI+
Sbjct: 216 TWDWVILILTFYTAIMVPYNVSFKTKQNNIA------------WLVLDSVVDVIFLVDIV 263

Query: 469 INFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLI----FGSGSEELIGLL 524
           +NF TT+V    EV+S P  I ++Y K WF+ID+++ +P+D++        G   L   L
Sbjct: 264 LNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSL 323

Query: 525 KTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQ-PHMDSRI 583
           K  RLLRL RVARKLD Y EYGAAVL LL+C F L+AHWLACIWY+IG+ E    + + I
Sbjct: 324 KVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTI 383

Query: 584 ---GWLHNLGDQIGKPYN---SSGL--GGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTN 635
               WL+ L   IG PY    S+G+  GGPS    YV++LYFT +SLT++GFGN++P T+
Sbjct: 384 QIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTD 443

Query: 636 SEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQ 695
            EK+FS+ +M++GSL+YA+IFGNV+ I Q++Y+ T RYH  +  VR+F++ +Q+P  L +
Sbjct: 444 VEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSE 503

Query: 696 RLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALA 755
           R+ +Y    WS + GID   VL   P+ ++ADIC+HLNR +      FR A+ GCLRALA
Sbjct: 504 RVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALA 563

Query: 756 MKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAIL 799
           ++F+T H  PGD + HAG+ + AL F+  GS+E+++ D VVAIL
Sbjct: 564 VEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAIL 607



 Score =  103 bits (258), Expect = 5e-22
 Identities = 50/146 (34%), Positives = 85/146 (58%), Gaps = 5/146 (3%)

Query: 4   RRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRP 63
           +RG VAPQNTFL+ I+R+    S  F++ NA++ +  V+Y NDGFC+L GY RA+VMQ+ 
Sbjct: 5   KRGLVAPQNTFLENIVRRSSESS--FLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKS 62

Query: 64  CTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVI 123
            TC F++G  T ++   ++ Q     E    E+  Y+K+ +     + + P++NE   V+
Sbjct: 63  STCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVV 122

Query: 124 MFILNFEVVMEKDMVGSPAHDTNHRG 149
           +F+  F+ +    +   P  D + +G
Sbjct: 123 LFLCTFKDI---TLFKQPIEDDSTKG 145


>gi|27437001 potassium voltage-gated channel, subfamily H, member 1
           isoform 1 [Homo sapiens]
          Length = 989

 Score =  408 bits (1049), Expect = e-113
 Identities = 213/496 (42%), Positives = 305/496 (61%), Gaps = 59/496 (11%)

Query: 353 TSDREII---APKIK--ERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFK 407
           TS R ++   AP ++  E  H  + ++ +VL LG+D+LP+YK +AP+     ILHY  FK
Sbjct: 159 TSSRGVLQQLAPSVQKGENVHKHS-RLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFK 217

Query: 408 AVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDI 467
             WDW+IL+L  YTA+  PY+ +F  ++                  VVD IVD++F+VDI
Sbjct: 218 TTWDWIILILTFYTAILVPYNVSFKTRQNNVA------------WLVVDSIVDVIFLVDI 265

Query: 468 LINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIF-------------- 513
           ++NF TT+V    EV+S P  I ++Y K WF+ID+++ +P+D++                
Sbjct: 266 VLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDP 325

Query: 514 -----------------GSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCT 556
                              G   L   LK  RLLRL RVARKLD Y EYGAAVL LL+C 
Sbjct: 326 GKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCV 385

Query: 557 FALIAHWLACIWYAIGNMEQPHMDSRI----GWLHNLGDQIGKPYNSSGLG------GPS 606
           F L AHW+ACIWY+IG+ E    D++      WL+ L   IG PY  +G G      GPS
Sbjct: 386 FGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPS 445

Query: 607 IKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRL 666
               Y+++LYFT +SLTSVGFGN++P+T+ EKIF++ +M+IGSL+YA+IFGNV+ I Q++
Sbjct: 446 KNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQM 505

Query: 667 YSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQA 726
           Y+ T RYH  +  VR+F++ +Q+P  L +R+ +Y    WS + GID   VL+  P+ ++A
Sbjct: 506 YANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRA 565

Query: 727 DICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGS 786
           DIC+HLNR + +    FR A+ GCLRALAM+F+T H  PGD + HAG+ + +L F+  GS
Sbjct: 566 DICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGS 625

Query: 787 IEILRGDVVVAILGMG 802
           +E+++ D VVAILG G
Sbjct: 626 LEVIQDDEVVAILGKG 641



 Score =  106 bits (264), Expect = 1e-22
 Identities = 49/126 (38%), Positives = 75/126 (59%), Gaps = 2/126 (1%)

Query: 4   RRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRP 63
           RRG VAPQNTFL+ I+R+       F++ NA++ +  ++Y NDGFC+L GY RAEVMQ+ 
Sbjct: 7   RRGLVAPQNTFLENIVRR--SNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKS 64

Query: 64  CTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVI 123
            TC F++G  T +    ++ Q     E    EI  Y+K+ +     V + P++NE   V+
Sbjct: 65  STCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVV 124

Query: 124 MFILNF 129
           +F+  F
Sbjct: 125 LFLCTF 130


>gi|38569493 potassium voltage-gated channel, subfamily H
           (eag-related), member 3 [Homo sapiens]
          Length = 1083

 Score =  394 bits (1013), Expect = e-109
 Identities = 220/490 (44%), Positives = 299/490 (61%), Gaps = 55/490 (11%)

Query: 385 LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATE 444
           LPEYK+ A R   + +LH    +A WD  ILL  +Y AV  PYS             A E
Sbjct: 202 LPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAVTVPYSVCV--------STARE 253

Query: 445 CGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVA 504
              A  P +V DL V+++FI+DI++NFRTT+V+ + +VV  P  I +HY   WFL+D++A
Sbjct: 254 PSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYVTTWFLLDVIA 313

Query: 505 AIPFDLL-------IFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTF 557
           A+PFDLL        FG+       LLKT RLLRL+R+  +LDRYS+Y A VL LLM  F
Sbjct: 314 ALPFDLLHAFKVNVYFGAH------LLKTVRLLRLLRLLPRLDRYSQYSAVVLTLLMAVF 367

Query: 558 ALIAHWLACIWYAIGNMEQPHMDSR---IGWLHNLGDQIGKPY----------NSSG--- 601
           AL+AHW+AC+W+ IG  E    +S    IGWL  L  ++  PY          NSSG   
Sbjct: 368 ALLAHWVACVWFYIGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSD 427

Query: 602 ---------------LGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVML 646
                          LGGPS++  Y+T+LYF  SSLTSVGFGNVS NT++EKIFSIC ML
Sbjct: 428 NCSSSSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTML 487

Query: 647 IGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWS 706
           IG+LM+A +FGNV+AIIQR+Y+    YH++   +R++IR H+IP PL+QR+ EYFQ  W+
Sbjct: 488 IGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWA 547

Query: 707 YTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPG 766
             NGID   +L+  P+ L+ADI +HL++ +LQ    F  A++GCLRAL++  +     PG
Sbjct: 548 VNNGIDTTELLQSLPDELRADIAMHLHKEVLQ-LPLFEAASRGCLRALSLALRPAFCTPG 606

Query: 767 DTLVHAGDLLTALYFISRGSIEILRGDVVVAILGMGWGAGTGLEMPSAASRGASLLNMQS 826
           + L+H GD L ALYF+  GS+E+L+G  V+AILG   G   G E+P       +  +++ 
Sbjct: 607 EYLIHQGDALQALYFVCSGSMEVLKGGTVLAILGK--GDLIGCELPRREQVVKANADVKG 664

Query: 827 LGLWTWDCLQ 836
           L      CLQ
Sbjct: 665 LTYCVLQCLQ 674



 Score =  146 bits (369), Expect = 7e-35
 Identities = 74/159 (46%), Positives = 98/159 (61%), Gaps = 11/159 (6%)

Query: 1   MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENC-AVIYCNDGFCELCGYSRAEV 59
           MP  RG +APQNTFLDTI  +F+G    F++ NA+V     V+YC+DGFC+L G+SRAEV
Sbjct: 1   MPAMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEV 60

Query: 60  MQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNED 119
           MQR C C FL+GP T      QI +AL   +E K E+  YRK G  F CL+DV+P+KNE 
Sbjct: 61  MQRGCACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEK 120

Query: 120 GAVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPG 158
           G V +F+++ + + E          T +RG P  W   G
Sbjct: 121 GEVALFLVSHKDISE----------TKNRGGPDRWKETG 149


>gi|38327037 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 3 [Homo sapiens]
          Length = 774

 Score =  154 bits (389), Expect = 3e-37
 Identities = 109/420 (25%), Positives = 189/420 (45%), Gaps = 54/420 (12%)

Query: 398 WTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDL 457
           W I  YS F+  WD ++LLL++   +  P    F     EE  P         P  V ++
Sbjct: 84  WIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFF---KEENSP---------PWIVFNV 131

Query: 458 IVDIMFIVDILINFRT-TYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSG 516
           + D  F++D+++NFRT   V    E++  P  I   Y + WFL+D++++IP D +     
Sbjct: 132 LSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVE 191

Query: 517 SEELIG--LLKTARLLRLVRVAR--------KLDRYSEY--------------GAAV--L 550
            E  +   + KTAR LR+VR  +        +L R   Y               +AV  +
Sbjct: 192 LEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRI 251

Query: 551 FLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDK 610
           F L+    L+ HW  C+ + +  ++    D  +   H +    G+ Y+            
Sbjct: 252 FNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWGRQYSH----------- 300

Query: 611 YVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGT 670
              AL+   S +  +G+G  +P    +   ++  M++G+  YA   G+ +A+IQ L S  
Sbjct: 301 ---ALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSR 357

Query: 671 ARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICL 730
            +Y  +  +V +++ FH++P   RQR+ EY++H +      D  ++L    E L+ +I  
Sbjct: 358 RQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQ-GKMFDEESILGELSEPLREEIIN 416

Query: 731 HLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEIL 790
              R L+ H   F  A    + A+  K +     PGD +V  G +   +YFI  G + +L
Sbjct: 417 FTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVL 476


>gi|4885407 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 4 [Homo sapiens]
          Length = 1203

 Score =  152 bits (384), Expect = 1e-36
 Identities = 104/418 (24%), Positives = 188/418 (44%), Gaps = 52/418 (12%)

Query: 398 WTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDL 457
           W I  YS F+  WD  +LLL++   +  P    F   E               P  V ++
Sbjct: 253 WIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTT------------PWIVFNV 300

Query: 458 IVDIMFIVDILINFRT-TYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSG 516
           + D  F++D+++NFRT   V  N E++  P RI + Y K WF++D +++IP D +     
Sbjct: 301 VSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVE 360

Query: 517 SEELIGLLKTARLLRLVRVAR--------KLDRYSEY--------------GAAVLFL-- 552
           +     + KTAR LR+VR  +        +L R   Y               +AV+ +  
Sbjct: 361 TRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVN 420

Query: 553 LMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYV 612
           L+    L+ HW  C+ + +  ++    D  +   + + +  GK Y+              
Sbjct: 421 LIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSY------------- 467

Query: 613 TALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTAR 672
            AL+   S +  +G+G  +P   S+   ++  M++G+  YA   G+ +A+IQ L S   +
Sbjct: 468 -ALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQ 526

Query: 673 YHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHL 732
           Y  +  +V +++ FH++P   RQR+ +Y++H +      D  ++L    E L+ +I    
Sbjct: 527 YQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQ-GKMFDEESILGELSEPLREEIINFN 585

Query: 733 NRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEIL 790
            R L+     F  A    + ++  K +     PGD ++  G +   +YFI  G + +L
Sbjct: 586 CRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVL 643


>gi|156071470 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 2 [Homo sapiens]
          Length = 889

 Score =  150 bits (380), Expect = 4e-36
 Identities = 104/418 (24%), Positives = 189/418 (45%), Gaps = 52/418 (12%)

Query: 398 WTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDL 457
           W I  YS F+  WD+ +LL ++   +  P    F   ET              P  V ++
Sbjct: 202 WIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDETTA------------PWIVFNV 249

Query: 458 IVDIMFIVDILINFRTTYV-NANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIF--- 513
           + D  F++D+++NFRT  V   N E++  P +I   Y + WF++D V++IP D +     
Sbjct: 250 VSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDYIFLIVE 309

Query: 514 -GSGSE-----------ELIGLLKTARLLRLVRVARKLDRYSE-----YGAAVLFLLMCT 556
            G  SE               +L   RLLRL R+ R + ++ E     Y  A   + +C 
Sbjct: 310 KGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICN 369

Query: 557 FA----LIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYV 612
                 L+ HW  C+ + +  ++      R  W+           + +G+   S  + Y 
Sbjct: 370 LISMMLLLCHWDGCLQFLVPMLQD---FPRNCWV-----------SINGMVNHSWSELYS 415

Query: 613 TALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTAR 672
            AL+   S +  +G+G  +P + ++   ++  M++G+  YA   G+ +A+IQ L S   +
Sbjct: 416 FALFKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQ 475

Query: 673 YHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHL 732
           Y  +  +V +++ FH++P   RQ++ +Y++H +      D +++L      L+ +I    
Sbjct: 476 YQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQ-GKMFDEDSILGELNGPLREEIVNFN 534

Query: 733 NRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEIL 790
            R L+     F  A    + A+  K K     PGD ++  G +   +YFI  G + +L
Sbjct: 535 CRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVL 592


>gi|116325989 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 1 [Homo sapiens]
          Length = 890

 Score =  149 bits (376), Expect = 1e-35
 Identities = 101/413 (24%), Positives = 190/413 (46%), Gaps = 52/413 (12%)

Query: 398 WTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDL 457
           W I  YS F+  WD ++L++++   V  P    F  ++T              P  + ++
Sbjct: 133 WIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTT------------PWIIFNV 180

Query: 458 IVDIMFIVDILINFRTTYVNANE-EVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIF--- 513
             D +F++D+++NFRT  VN +  E++  P  I ++Y K WF++D +++IP D +     
Sbjct: 181 ASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVE 240

Query: 514 -GSGSE--------------ELIGLLKTARLLRLVRVARKLDR-----YSEYGAAV-LFL 552
            G  SE              +++ LL+  RL RL+R   + +      Y    A V +F 
Sbjct: 241 KGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFN 300

Query: 553 LMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYV 612
           L+    L+ HW  C+ + +  ++    D  +     + D  GK Y+              
Sbjct: 301 LIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSY------------- 347

Query: 613 TALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTAR 672
            AL+   S +  +G+G  +P + S+   ++  M++G+  YA   G+ +A+IQ L S   +
Sbjct: 348 -ALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQ 406

Query: 673 YHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHL 732
           Y  +  +V +++ FH++P  +RQ++ +Y++H +      D   +L    + L+ +I    
Sbjct: 407 YQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQ-GKIFDEENILNELNDPLREEIVNFN 465

Query: 733 NRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRG 785
            R L+     F  A    + A+  K +     PGD ++  G +   +YFI  G
Sbjct: 466 CRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHG 518


>gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2
           [Homo sapiens]
          Length = 676

 Score =  138 bits (347), Expect = 3e-32
 Identities = 100/396 (25%), Positives = 192/396 (48%), Gaps = 35/396 (8%)

Query: 454 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHY-FKGWFLIDMVAAIPFDLLI 512
           V+D   D+++++D+L+  RT ++     +VS   R+  HY     F +D+++ +P DL  
Sbjct: 187 VLDYSADVLYVLDVLVRARTGFLEQGL-MVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 245

Query: 513 FGSGSEELIGLLKTARLLRLVRVARKLDRYS---------EYGAAVLFLLMCTFALIAHW 563
              G+      ++  RLL+  R+    DR             G  VL++L     +I HW
Sbjct: 246 LKVGTN--YPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYIL-----IIIHW 298

Query: 564 LACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLT 623
            ACI++AI        DS   W++     I  P +        +  KY+ +LY++  +LT
Sbjct: 299 NACIYFAISKFIGFGTDS---WVY---PNISIPEHGR------LSRKYIYSLYWSTLTLT 346

Query: 624 SVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREF 683
           ++G     P  + E +F +   L+G L++A+I GNV ++I  + +  A +  ++  ++++
Sbjct: 347 TIG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQY 405

Query: 684 IRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPF 743
           ++F ++   L  R+  +F + W+    +D   VLK  P+ L+A+I ++++   L+  + F
Sbjct: 406 MQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIF 465

Query: 744 RGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGMGW 803
           +    G L  L +K + T   PGD +   GD+   +Y I+ G + ++  D V   + +  
Sbjct: 466 QDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSD 525

Query: 804 GAGTG----LEMPSAASRGASLLNMQSLGLWTWDCL 835
           G+  G    L +  + S      N++S+G     CL
Sbjct: 526 GSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCL 561


>gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Homo
           sapiens]
          Length = 694

 Score =  138 bits (347), Expect = 3e-32
 Identities = 100/396 (25%), Positives = 192/396 (48%), Gaps = 35/396 (8%)

Query: 454 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHY-FKGWFLIDMVAAIPFDLLI 512
           V+D   D+++++D+L+  RT ++     +VS   R+  HY     F +D+++ +P DL  
Sbjct: 205 VLDYSADVLYVLDVLVRARTGFLEQGL-MVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 263

Query: 513 FGSGSEELIGLLKTARLLRLVRVARKLDRYS---------EYGAAVLFLLMCTFALIAHW 563
              G+      ++  RLL+  R+    DR             G  VL++L     +I HW
Sbjct: 264 LKVGTN--YPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYIL-----IIIHW 316

Query: 564 LACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLT 623
            ACI++AI        DS   W++     I  P +        +  KY+ +LY++  +LT
Sbjct: 317 NACIYFAISKFIGFGTDS---WVY---PNISIPEHGR------LSRKYIYSLYWSTLTLT 364

Query: 624 SVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREF 683
           ++G     P  + E +F +   L+G L++A+I GNV ++I  + +  A +  ++  ++++
Sbjct: 365 TIG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQY 423

Query: 684 IRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPF 743
           ++F ++   L  R+  +F + W+    +D   VLK  P+ L+A+I ++++   L+  + F
Sbjct: 424 MQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIF 483

Query: 744 RGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGMGW 803
           +    G L  L +K + T   PGD +   GD+   +Y I+ G + ++  D V   + +  
Sbjct: 484 QDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSD 543

Query: 804 GAGTG----LEMPSAASRGASLLNMQSLGLWTWDCL 835
           G+  G    L +  + S      N++S+G     CL
Sbjct: 544 GSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCL 579


>gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1
           [Homo sapiens]
          Length = 759

 Score =  130 bits (328), Expect = 4e-30
 Identities = 93/388 (23%), Positives = 185/388 (47%), Gaps = 19/388 (4%)

Query: 454 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIF 513
           ++D + DI++++D+ +  RT Y+     V      I  +     F +D+++ IP DLL F
Sbjct: 271 ILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYF 330

Query: 514 GSG-SEELIGLLKTARLLRLVRVARKLDRYSEYGAAV-LFLLMCTFALIAHWLACIWYAI 571
             G +   I L +  R  R+    ++ +  + Y     +  L+    +I HW AC++Y+I
Sbjct: 331 KLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSI 390

Query: 572 GNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVS 631
                   D+   W++          N    G   +  KYV +LY++  +LT++G     
Sbjct: 391 SKAIGFGNDT---WVY-------PDINDPEFG--RLARKYVYSLYWSTLTLTTIG-ETPP 437

Query: 632 PNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPN 691
           P  +SE +F +   LIG L++A+I GN+ ++I  + +  A +  ++  +++++ F  +  
Sbjct: 438 PVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSK 497

Query: 692 PLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCL 751
            + +R+ ++F + W+    +D   VLK  P+ L+A+I ++++   L+  + F     G L
Sbjct: 498 DMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLL 557

Query: 752 RALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGMGWGAGTG--- 808
             L +K +     PGD +   GD+   +Y I  G + ++  D V   + +  G+  G   
Sbjct: 558 VELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEIS 617

Query: 809 -LEMPSAASRGASLLNMQSLGLWTWDCL 835
            L +  + +      N++S+G     CL
Sbjct: 618 ILNIKGSKAGNRRTANIKSIGYSDLFCL 645


>gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [Homo
           sapiens]
          Length = 690

 Score =  130 bits (328), Expect = 4e-30
 Identities = 93/388 (23%), Positives = 185/388 (47%), Gaps = 19/388 (4%)

Query: 454 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIF 513
           ++D + DI++++D+ +  RT Y+     V      I  +     F +D+++ IP DLL F
Sbjct: 202 ILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYF 261

Query: 514 GSG-SEELIGLLKTARLLRLVRVARKLDRYSEYGAAV-LFLLMCTFALIAHWLACIWYAI 571
             G +   I L +  R  R+    ++ +  + Y     +  L+    +I HW AC++Y+I
Sbjct: 262 KLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSI 321

Query: 572 GNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVS 631
                   D+   W++          N    G   +  KYV +LY++  +LT++G     
Sbjct: 322 SKAIGFGNDT---WVY-------PDINDPEFG--RLARKYVYSLYWSTLTLTTIG-ETPP 368

Query: 632 PNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPN 691
           P  +SE +F +   LIG L++A+I GN+ ++I  + +  A +  ++  +++++ F  +  
Sbjct: 369 PVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSK 428

Query: 692 PLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCL 751
            + +R+ ++F + W+    +D   VLK  P+ L+A+I ++++   L+  + F     G L
Sbjct: 429 DMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLL 488

Query: 752 RALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGMGWGAGTG--- 808
             L +K +     PGD +   GD+   +Y I  G + ++  D V   + +  G+  G   
Sbjct: 489 VELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEIS 548

Query: 809 -LEMPSAASRGASLLNMQSLGLWTWDCL 835
            L +  + +      N++S+G     CL
Sbjct: 549 ILNIKGSKAGNRRTANIKSIGYSDLFCL 576


>gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]
          Length = 664

 Score =  121 bits (304), Expect = 3e-27
 Identities = 100/404 (24%), Positives = 184/404 (45%), Gaps = 51/404 (12%)

Query: 454 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGW-FLIDMVAAIPFDLLI 512
           V+D + D+++I D+ I  RT ++     +V    ++  +Y     F +D+ + IP DL+ 
Sbjct: 177 VLDYVSDVVYIADLFIRLRTGFLEQGL-LVKDTKKLRDNYIHTLQFKLDVASIIPTDLIY 235

Query: 513 FGSGSEELIGLLKTARLLRLVRVARKLDRYS---------EYGAAVLFLLMCTFALIAHW 563
           F          ++  RLL   R+    DR                VL++L+     I HW
Sbjct: 236 FAVDIHS--PEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILV-----IIHW 288

Query: 564 LACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKD--------KYVTAL 615
            ACI+YAI       +D+   W++                 P+I D        +Y+  L
Sbjct: 289 NACIYYAISKSIGFGVDT---WVY-----------------PNITDPEYGYLAREYIYCL 328

Query: 616 YFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHT 675
           Y++  +LT++G     P  + E +F I   LIG L++A+I GNV ++I  + +  A +  
Sbjct: 329 YWSTLTLTTIG-ETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQA 387

Query: 676 QMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRS 735
           ++  V+ +++F ++   +  ++  +F + W+    +D   +LK  P  L+A+I ++++ S
Sbjct: 388 KIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLS 447

Query: 736 LLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVV 795
            L+  + F     G L  L +K +     PGD +   GD+   +Y I  G + ++  D V
Sbjct: 448 TLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGV 507

Query: 796 V--AILGMG--WGAGTGLEMPSAASRGASLLNMQSLGLWTWDCL 835
              A+L  G  +G  + L +  +        N++SLG     CL
Sbjct: 508 TQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCL 551


>gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]
          Length = 575

 Score =  117 bits (294), Expect = 4e-26
 Identities = 93/404 (23%), Positives = 188/404 (46%), Gaps = 26/404 (6%)

Query: 441 PATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGW-FL 499
           P  + GY    L V+D   D+++++D+++ F T ++     VV   GRI+  Y + W F 
Sbjct: 59  PDLQHGYLVAWL-VLDYTSDLLYLLDMVVRFHTGFLEQGILVVDK-GRISSRYVRTWSFF 116

Query: 500 IDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEY----GAAVLFLLMC 555
           +D+ + +P D++    G       L+  R LR  R+    DR         A  +  LM 
Sbjct: 117 LDLASLMPTDVVYVRLGPHT--PTLRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLML 174

Query: 556 TFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTAL 615
              ++ HW +C+++A+        D+   W++          + +  G   ++ +Y+ + 
Sbjct: 175 YIFVVIHWNSCLYFALSRYLGFGRDA---WVYP---------DPAQPGFERLRRQYLYSF 222

Query: 616 YFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHT 675
           YF+   LT+VG     P    E +F +   L+  + +A+I G++S++I  + +  A ++ 
Sbjct: 223 YFSTLILTTVG-DTPPPAREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYP 281

Query: 676 QMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRS 735
               V+++++   +   L +R+ +++QH        +  A+L+  PE L+A++ + ++ S
Sbjct: 282 DHALVKKYMKLQHVNRKLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLS 341

Query: 736 LLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVV 795
            L   + F+      L  L +K +     PG+ +   GD+   +Y I  G + ++  D +
Sbjct: 342 TLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGI 401

Query: 796 V--AILGMG--WGAGTGLEMPSAASRGASLLNMQSLGLWTWDCL 835
              A+LG G  +G  + + +    S      N++SLG     CL
Sbjct: 402 TQYAVLGAGLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFCL 445


>gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]
          Length = 809

 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 90/451 (19%), Positives = 180/451 (39%), Gaps = 44/451 (9%)

Query: 350 ASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLP--EY--KLQAPR-IHRWTILHYS 404
           ASP + +    P +KE     TE   ++L      +P  EY  +++ P  I  +T   Y 
Sbjct: 160 ASPQTAKPTAVPPVKESDDKPTEHYYRLLWFKVKKMPLTEYLKRIKLPNSIDSYTDRLY- 218

Query: 405 PFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFI 464
               +W  L+ L   +   F P    F  +  +                + D+I DI+++
Sbjct: 219 ---LLWLLLVTLAYNWNCCFIPLRLVFPYQTADN----------IHYWLIADIICDIIYL 265

Query: 465 VDIL-INFRTTYVNANEEVVSHPGRIAVHYFKGW-FLIDMVAAIPFDLLIFGSGSEELIG 522
            D+L I  R  +V   + +V     +  HY     F +D+ + IPFD+     G   +  
Sbjct: 266 YDMLFIQPRLQFVRGGDIIVDS-NELRKHYRTSTKFQLDVASIIPFDICYLFFGFNPMFR 324

Query: 523 LLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFAL-IAHWLACIWYAIGNMEQPHMDS 581
             +  +          L+   +       +    + L I H  AC++Y   N E      
Sbjct: 325 ANRMLKYTSFFEFNHHLESIMDKAYIYRVIRTTGYLLFILHINACVYYWASNYEGI---G 381

Query: 582 RIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFS 641
              W+          Y+  G       ++Y+   Y+   +L ++G G   P T  E +F 
Sbjct: 382 TTRWV----------YDGEG-------NEYLRCYYWAVRTLITIG-GLPEPQTLFEIVFQ 423

Query: 642 ICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYF 701
           +     G  +++S+ G +  +I    +    +   M     ++  + IP  +++R+  ++
Sbjct: 424 LLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLVQKRVRTWY 483

Query: 702 QHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTT 761
           ++ W     +D + +LK  P  +Q  + + +N S++     F+G     +  + ++ K+ 
Sbjct: 484 EYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSV 543

Query: 762 HAPPGDTLVHAGDLLTALYFISRGSIEILRG 792
              PGD +   G++   +Y I  G +++L G
Sbjct: 544 LYLPGDFVCKKGEIGKEMYIIKHGEVQVLGG 574


>gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [Homo
            sapiens]
          Length = 1251

 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 62/344 (18%), Positives = 156/344 (45%), Gaps = 29/344 (8%)

Query: 454  VVDLIVDIMFIVDILI-NFRTTYVNANEEVVSHPGRIAVHYFKGW-FLIDMVAAIPFDLL 511
            ++D + D+++ +DI +   R  +V   + +++    +  +Y K   F +D+++ +P D L
Sbjct: 693  LMDYLCDLIYFLDITVFQTRLQFVRGGD-IITDKKDMRNNYLKSRRFKMDLLSLLPLDFL 751

Query: 512  IFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWL---ACIW 568
                G   L+ L +  + +       +L+  S    A ++ ++ T A + + L   +C++
Sbjct: 752  YLKVGVNPLLRLPRCLKYMAFFEFNSRLE--SILSKAYVYRVIRTTAYLLYSLHLNSCLY 809

Query: 569  YAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFG 628
            Y     +       +G  H + D +G              + Y+   YF   +L ++G G
Sbjct: 810  YWASAYQG------LGSTHWVYDGVG--------------NSYIRCYYFAVKTLITIG-G 848

Query: 629  NVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQ 688
               P T  E +F +     G   ++ + G +  ++    +G   Y + M    +++ F++
Sbjct: 849  LPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYK 908

Query: 689  IPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATK 748
            IP  ++ R++ ++++ W     +D + ++   P+ ++ D+ + +N +++     F+G  +
Sbjct: 909  IPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDR 968

Query: 749  GCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRG 792
              +  +  + ++    P D +   G++   +Y I  G +++L G
Sbjct: 969  QMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGG 1012


>gi|195947369 junction-mediating and regulatory protein [Homo
           sapiens]
          Length = 988

 Score = 41.6 bits (96), Expect = 0.003
 Identities = 38/133 (28%), Positives = 48/133 (36%), Gaps = 7/133 (5%)

Query: 176 RESSVRSGGAGGAGAPGAVVVDVDLTPAAPSSESLALDEVTAMDNHVAGLGPAEERRALV 235
           R  S    GA G    G    D    P +P+       E TA    V   GP   R +  
Sbjct: 55  RSGSREQAGARGGAEAGGAASDGSRGPGSPAGRGRP--EATASATLVRSPGP--RRSSAW 110

Query: 236 GPGSPPRSAPGQLPSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGV 295
             G  PRS    L  PR  S  P + G+   L R+  R      ++ S ADD     A  
Sbjct: 111 AEGGSPRSTRSLLGDPRLRS--PGSKGAESRL-RSPVRAKPIPGQKTSEADDAAGAAAAA 167

Query: 296 LPPPPRHASTGAM 308
             P PR A   ++
Sbjct: 168 ARPAPREAQVSSV 180


>gi|205361107 potassium channel, subfamily K, member 17 isoform 2
           [Homo sapiens]
          Length = 271

 Score = 41.2 bits (95), Expect = 0.004
 Identities = 16/54 (29%), Positives = 35/54 (64%)

Query: 612 VTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQR 665
           V + +F+ S++T++G+GN+SPNT + ++F I   L+G  +   +   +  ++Q+
Sbjct: 104 VGSFFFSVSTITTIGYGNLSPNTMAARLFCIFFALVGIPLNLVVLNRLGHLMQQ 157


>gi|17025230 potassium channel, subfamily K, member 17 isoform 1
           [Homo sapiens]
          Length = 332

 Score = 41.2 bits (95), Expect = 0.004
 Identities = 16/54 (29%), Positives = 35/54 (64%)

Query: 612 VTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQR 665
           V + +F+ S++T++G+GN+SPNT + ++F I   L+G  +   +   +  ++Q+
Sbjct: 104 VGSFFFSVSTITTIGYGNLSPNTMAARLFCIFFALVGIPLNLVVLNRLGHLMQQ 157


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.137    0.426 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,422,834
Number of Sequences: 37866
Number of extensions: 1732581
Number of successful extensions: 7040
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 70
Number of HSP's successfully gapped in prelim test: 152
Number of HSP's that attempted gapping in prelim test: 6677
Number of HSP's gapped (non-prelim): 438
length of query: 888
length of database: 18,247,518
effective HSP length: 111
effective length of query: 777
effective length of database: 14,044,392
effective search space: 10912492584
effective search space used: 10912492584
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.