Guide to the Human Genome
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Search of human proteins with 24797108

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|24797108 calcium-binding tyrosine phosphorylation-regulated
protein isoform a [Homo sapiens]
         (493 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|24797108 calcium-binding tyrosine phosphorylation-regulated p...   958   0.0  
gi|24797114 calcium-binding tyrosine phosphorylation-regulated p...   910   0.0  
gi|24797118 calcium-binding tyrosine phosphorylation-regulated p...   364   e-101
gi|24797116 calcium-binding tyrosine phosphorylation-regulated p...   363   e-100
gi|24797112 calcium-binding tyrosine phosphorylation-regulated p...   363   e-100
gi|24797110 calcium-binding tyrosine phosphorylation-regulated p...   169   4e-42
gi|91982772 mucin 17 [Homo sapiens]                                    59   1e-08
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]              48   2e-05
gi|8394343 sperm autoantigenic protein 17 [Homo sapiens]               46   7e-05
gi|153945728 microtubule-associated protein 1B [Homo sapiens]          43   7e-04
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     42   0.001
gi|10092601 eukaryotic translation initiation factor 4 gamma, 3 ...    42   0.002
gi|19923559 EMSY protein [Homo sapiens]                                40   0.005
gi|71044479 death inducer-obliterator 1 isoform c [Homo sapiens]       40   0.006
gi|110349719 titin isoform N2-A [Homo sapiens]                         39   0.011
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   39   0.011
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   39   0.011
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   39   0.011
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    39   0.011
gi|239743293 PREDICTED: mucin 12 [Homo sapiens]                        39   0.011
gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo sap...    39   0.011
gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo sap...    39   0.011
gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo sapi...    39   0.011
gi|148613886 regulatory factor X domain containing 2 [Homo sapiens]    39   0.014
gi|33350928 disabled homolog 1 [Homo sapiens]                          38   0.018
gi|21264565 AT rich interactive domain 1A isoform a [Homo sapiens]     38   0.018
gi|21264575 AT rich interactive domain 1A isoform b [Homo sapiens]     38   0.018
gi|237681125 breast cancer 1, early onset isoform 5 [Homo sapiens]     38   0.024
gi|237681123 breast cancer 1, early onset isoform 4 [Homo sapiens]     38   0.024
gi|11641239 hypothetical protein LOC53838 [Homo sapiens]               38   0.024

>gi|24797108 calcium-binding tyrosine phosphorylation-regulated
           protein isoform a [Homo sapiens]
          Length = 493

 Score =  958 bits (2476), Expect = 0.0
 Identities = 493/493 (100%), Positives = 493/493 (100%)

Query: 1   MISSKPRLVVPYGLKTLLEGISRAVLKTNPSNINQFAAAYFQELTMYRGNTTMDIKDLVK 60
           MISSKPRLVVPYGLKTLLEGISRAVLKTNPSNINQFAAAYFQELTMYRGNTTMDIKDLVK
Sbjct: 1   MISSKPRLVVPYGLKTLLEGISRAVLKTNPSNINQFAAAYFQELTMYRGNTTMDIKDLVK 60

Query: 61  QFHQIKVEKWSEGTTPQKKLECLKEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTT 120
           QFHQIKVEKWSEGTTPQKKLECLKEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTT
Sbjct: 61  QFHQIKVEKWSEGTTPQKKLECLKEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTT 120

Query: 121 QFPSVYAVPGTEQTEAVGGLSSKPATPKTTTPPSSPPPTAVSPEFAYVPADPAQLAAQML 180
           QFPSVYAVPGTEQTEAVGGLSSKPATPKTTTPPSSPPPTAVSPEFAYVPADPAQLAAQML
Sbjct: 121 QFPSVYAVPGTEQTEAVGGLSSKPATPKTTTPPSSPPPTAVSPEFAYVPADPAQLAAQML 180

Query: 181 GKVSSIHSDQSDVLMVDVATSMPVVIKEVPSSEAAEDVMVAAPLVCSGKVLEVQVVNQTS 240
           GKVSSIHSDQSDVLMVDVATSMPVVIKEVPSSEAAEDVMVAAPLVCSGKVLEVQVVNQTS
Sbjct: 181 GKVSSIHSDQSDVLMVDVATSMPVVIKEVPSSEAAEDVMVAAPLVCSGKVLEVQVVNQTS 240

Query: 241 VHVDLGSQPKENEAEPSTASSVPLQDEQEPPAYDQAPEVTLQADIEVMSTVHISSVYNDV 300
           VHVDLGSQPKENEAEPSTASSVPLQDEQEPPAYDQAPEVTLQADIEVMSTVHISSVYNDV
Sbjct: 241 VHVDLGSQPKENEAEPSTASSVPLQDEQEPPAYDQAPEVTLQADIEVMSTVHISSVYNDV 300

Query: 301 PVTEGVVYIEQLPEQIVIPFTDQVACLKENEQSKENEQSPRVSPKSVVEKTTSGMSKKSV 360
           PVTEGVVYIEQLPEQIVIPFTDQVACLKENEQSKENEQSPRVSPKSVVEKTTSGMSKKSV
Sbjct: 301 PVTEGVVYIEQLPEQIVIPFTDQVACLKENEQSKENEQSPRVSPKSVVEKTTSGMSKKSV 360

Query: 361 ESVKLAQLEENAKYSSVYMEAEATALLSDTSLKGQPEVPAQLLDAEGAIKIGSEKSLHLE 420
           ESVKLAQLEENAKYSSVYMEAEATALLSDTSLKGQPEVPAQLLDAEGAIKIGSEKSLHLE
Sbjct: 361 ESVKLAQLEENAKYSSVYMEAEATALLSDTSLKGQPEVPAQLLDAEGAIKIGSEKSLHLE 420

Query: 421 VEITSIVSDNTGQEESGENSVPQEMEGKPVLSGEAAEAVHSGTSVKSSSGPFPPAPEGLT 480
           VEITSIVSDNTGQEESGENSVPQEMEGKPVLSGEAAEAVHSGTSVKSSSGPFPPAPEGLT
Sbjct: 421 VEITSIVSDNTGQEESGENSVPQEMEGKPVLSGEAAEAVHSGTSVKSSSGPFPPAPEGLT 480

Query: 481 APEIEPEGESTAE 493
           APEIEPEGESTAE
Sbjct: 481 APEIEPEGESTAE 493


>gi|24797114 calcium-binding tyrosine phosphorylation-regulated
           protein isoform b [Homo sapiens]
          Length = 475

 Score =  910 bits (2353), Expect = 0.0
 Identities = 475/493 (96%), Positives = 475/493 (96%), Gaps = 18/493 (3%)

Query: 1   MISSKPRLVVPYGLKTLLEGISRAVLKTNPSNINQFAAAYFQELTMYRGNTTMDIKDLVK 60
           MISSKPRLVVPYGLKTLLEGISRAVLKTNPSNINQFAAAYFQELTMYR            
Sbjct: 1   MISSKPRLVVPYGLKTLLEGISRAVLKTNPSNINQFAAAYFQELTMYR------------ 48

Query: 61  QFHQIKVEKWSEGTTPQKKLECLKEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTT 120
                 VEKWSEGTTPQKKLECLKEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTT
Sbjct: 49  ------VEKWSEGTTPQKKLECLKEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTT 102

Query: 121 QFPSVYAVPGTEQTEAVGGLSSKPATPKTTTPPSSPPPTAVSPEFAYVPADPAQLAAQML 180
           QFPSVYAVPGTEQTEAVGGLSSKPATPKTTTPPSSPPPTAVSPEFAYVPADPAQLAAQML
Sbjct: 103 QFPSVYAVPGTEQTEAVGGLSSKPATPKTTTPPSSPPPTAVSPEFAYVPADPAQLAAQML 162

Query: 181 GKVSSIHSDQSDVLMVDVATSMPVVIKEVPSSEAAEDVMVAAPLVCSGKVLEVQVVNQTS 240
           GKVSSIHSDQSDVLMVDVATSMPVVIKEVPSSEAAEDVMVAAPLVCSGKVLEVQVVNQTS
Sbjct: 163 GKVSSIHSDQSDVLMVDVATSMPVVIKEVPSSEAAEDVMVAAPLVCSGKVLEVQVVNQTS 222

Query: 241 VHVDLGSQPKENEAEPSTASSVPLQDEQEPPAYDQAPEVTLQADIEVMSTVHISSVYNDV 300
           VHVDLGSQPKENEAEPSTASSVPLQDEQEPPAYDQAPEVTLQADIEVMSTVHISSVYNDV
Sbjct: 223 VHVDLGSQPKENEAEPSTASSVPLQDEQEPPAYDQAPEVTLQADIEVMSTVHISSVYNDV 282

Query: 301 PVTEGVVYIEQLPEQIVIPFTDQVACLKENEQSKENEQSPRVSPKSVVEKTTSGMSKKSV 360
           PVTEGVVYIEQLPEQIVIPFTDQVACLKENEQSKENEQSPRVSPKSVVEKTTSGMSKKSV
Sbjct: 283 PVTEGVVYIEQLPEQIVIPFTDQVACLKENEQSKENEQSPRVSPKSVVEKTTSGMSKKSV 342

Query: 361 ESVKLAQLEENAKYSSVYMEAEATALLSDTSLKGQPEVPAQLLDAEGAIKIGSEKSLHLE 420
           ESVKLAQLEENAKYSSVYMEAEATALLSDTSLKGQPEVPAQLLDAEGAIKIGSEKSLHLE
Sbjct: 343 ESVKLAQLEENAKYSSVYMEAEATALLSDTSLKGQPEVPAQLLDAEGAIKIGSEKSLHLE 402

Query: 421 VEITSIVSDNTGQEESGENSVPQEMEGKPVLSGEAAEAVHSGTSVKSSSGPFPPAPEGLT 480
           VEITSIVSDNTGQEESGENSVPQEMEGKPVLSGEAAEAVHSGTSVKSSSGPFPPAPEGLT
Sbjct: 403 VEITSIVSDNTGQEESGENSVPQEMEGKPVLSGEAAEAVHSGTSVKSSSGPFPPAPEGLT 462

Query: 481 APEIEPEGESTAE 493
           APEIEPEGESTAE
Sbjct: 463 APEIEPEGESTAE 475


>gi|24797118 calcium-binding tyrosine phosphorylation-regulated
           protein isoform e [Homo sapiens]
          Length = 221

 Score =  364 bits (935), Expect = e-101
 Identities = 183/192 (95%), Positives = 184/192 (95%)

Query: 1   MISSKPRLVVPYGLKTLLEGISRAVLKTNPSNINQFAAAYFQELTMYRGNTTMDIKDLVK 60
           MISSKPRLVVPYGLKTLLEGISRAVLKTNPSNINQFAAAYFQELTMYRGNTTMDIKDLVK
Sbjct: 1   MISSKPRLVVPYGLKTLLEGISRAVLKTNPSNINQFAAAYFQELTMYRGNTTMDIKDLVK 60

Query: 61  QFHQIKVEKWSEGTTPQKKLECLKEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTT 120
           QFHQIKVEKWSEGTTPQKKLECLKEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTT
Sbjct: 61  QFHQIKVEKWSEGTTPQKKLECLKEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTT 120

Query: 121 QFPSVYAVPGTEQTEAVGGLSSKPATPKTTTPPSSPPPTAVSPEFAYVPADPAQLAAQML 180
           QFPSVYAVPGTEQTEAVGGLSSKPATPKTTTPPSSPPPTAVSPEFAYVPADPAQLAAQML
Sbjct: 121 QFPSVYAVPGTEQTEAVGGLSSKPATPKTTTPPSSPPPTAVSPEFAYVPADPAQLAAQML 180

Query: 181 GKVSSIHSDQSD 192
             V+   S   D
Sbjct: 181 EDVAKKSSGSGD 192


>gi|24797116 calcium-binding tyrosine phosphorylation-regulated
           protein isoform c [Homo sapiens]
          Length = 379

 Score =  363 bits (932), Expect = e-100
 Identities = 181/185 (97%), Positives = 182/185 (98%)

Query: 1   MISSKPRLVVPYGLKTLLEGISRAVLKTNPSNINQFAAAYFQELTMYRGNTTMDIKDLVK 60
           MISSKPRLVVPYGLKTLLEGISRAVLKTNPSNINQFAAAYFQELTMYRGNTTMDIKDLVK
Sbjct: 1   MISSKPRLVVPYGLKTLLEGISRAVLKTNPSNINQFAAAYFQELTMYRGNTTMDIKDLVK 60

Query: 61  QFHQIKVEKWSEGTTPQKKLECLKEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTT 120
           QFHQIKVEKWSEGTTPQKKLECLKEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTT
Sbjct: 61  QFHQIKVEKWSEGTTPQKKLECLKEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTT 120

Query: 121 QFPSVYAVPGTEQTEAVGGLSSKPATPKTTTPPSSPPPTAVSPEFAYVPADPAQLAAQML 180
           QFPSVYAVPGTEQTEAVGGLSSKPATPKTTTPPSSPPPTAVSPEFAYVPADPAQLAAQML
Sbjct: 121 QFPSVYAVPGTEQTEAVGGLSSKPATPKTTTPPSSPPPTAVSPEFAYVPADPAQLAAQML 180

Query: 181 GKVSS 185
              +S
Sbjct: 181 AMATS 185


>gi|24797112 calcium-binding tyrosine phosphorylation-regulated
           protein isoform c [Homo sapiens]
          Length = 379

 Score =  363 bits (932), Expect = e-100
 Identities = 181/185 (97%), Positives = 182/185 (98%)

Query: 1   MISSKPRLVVPYGLKTLLEGISRAVLKTNPSNINQFAAAYFQELTMYRGNTTMDIKDLVK 60
           MISSKPRLVVPYGLKTLLEGISRAVLKTNPSNINQFAAAYFQELTMYRGNTTMDIKDLVK
Sbjct: 1   MISSKPRLVVPYGLKTLLEGISRAVLKTNPSNINQFAAAYFQELTMYRGNTTMDIKDLVK 60

Query: 61  QFHQIKVEKWSEGTTPQKKLECLKEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTT 120
           QFHQIKVEKWSEGTTPQKKLECLKEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTT
Sbjct: 61  QFHQIKVEKWSEGTTPQKKLECLKEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTT 120

Query: 121 QFPSVYAVPGTEQTEAVGGLSSKPATPKTTTPPSSPPPTAVSPEFAYVPADPAQLAAQML 180
           QFPSVYAVPGTEQTEAVGGLSSKPATPKTTTPPSSPPPTAVSPEFAYVPADPAQLAAQML
Sbjct: 121 QFPSVYAVPGTEQTEAVGGLSSKPATPKTTTPPSSPPPTAVSPEFAYVPADPAQLAAQML 180

Query: 181 GKVSS 185
              +S
Sbjct: 181 AMATS 185


>gi|24797110 calcium-binding tyrosine phosphorylation-regulated
           protein isoform d [Homo sapiens]
          Length = 281

 Score =  169 bits (429), Expect = 4e-42
 Identities = 83/87 (95%), Positives = 84/87 (96%)

Query: 99  MEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTEQTEAVGGLSSKPATPKTTTPPSSPPP 158
           MEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTEQTEAVGGLSSKPATPKTTTPPSSPPP
Sbjct: 1   MEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTEQTEAVGGLSSKPATPKTTTPPSSPPP 60

Query: 159 TAVSPEFAYVPADPAQLAAQMLGKVSS 185
           TAVSPEFAYVPADPAQLAAQML   +S
Sbjct: 61  TAVSPEFAYVPADPAQLAAQMLAMATS 87


>gi|91982772 mucin 17 [Homo sapiens]
          Length = 4493

 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 115/470 (24%), Positives = 168/470 (35%), Gaps = 91/470 (19%)

Query: 76  PQKKLECLKEPGKTSVESKVPTQMEKSTDT----DEDNVTRTEYSDKTTQFPSVYAVPGT 131
           P+  L C   P  TS+ES V +     + T     E   T    SD TT FPS      T
Sbjct: 79  PRMYLSCSTNPEMTSIESSVTSDTPGVSSTRMTPTESRTTSESTSDSTTLFPS-----ST 133

Query: 132 EQTEAVGGLSSKPATPK-TTTPPSSPPPTAVSPEFAYVPADPA---QLAAQMLGKV---- 183
           E T       S P TP+ T  P S+P   ++S   A+V   P    +    +  KV    
Sbjct: 134 EDT-------SSPTTPEGTDVPMSTPSEESISSTMAFVSTAPLPSFEAYTSLTYKVDMST 186

Query: 184 ---------SSIHSDQSDVLMVDV-------ATSMPVVIKEVPSSEAAEDVMVAAPLVCS 227
                    SS  + +S  +            TSMP    +V SSEA    ++  P    
Sbjct: 187 PLTTSTQASSSPTTPESTTIPKSTNSEGSTPLTSMPASTMKVASSEAI--TLLTTP---- 240

Query: 228 GKVLEVQVVNQTSVHVDLGSQPKENEAEPSTASSVPLQDEQEPPAYDQAPEVTLQADIEV 287
                V++    ++     S P   E  PS ++S P       P       V L    E 
Sbjct: 241 -----VEISTPVTISAQASSSPTTAEG-PSLSNSAP--SGGSTPLTRMPLSVMLVVSSEA 292

Query: 288 MSTVHISSVYNDVPVTEGVVYIEQLPEQIVIPFTDQVACLKENEQSKENEQSPRVSPKSV 347
            ST+  +    ++PV           E    P T +   +  +  + E       +P S 
Sbjct: 293 -STLSTTPAATNIPVITST-------EASSSPTTAEGTSIPTSTYT-EGSTPLTSTPAST 343

Query: 348 VEKTTSGMSKKSVESVKLAQL-EENAKYSSVYMEAEATALLSDTSLKGQPEVPAQLLDAE 406
           +   TS MS  S+  V  + L   + + SS+   AEAT++L+ T  +G    P   +   
Sbjct: 344 MPVATSEMSTLSITPVDTSTLVTTSTEPSSLPTTAEATSMLTSTLSEG--STPLTNMPVS 401

Query: 407 GAIKIGSEKSLHLEVEITSIV----------SDNTGQEESGENSVPQE---------MEG 447
             +   SE S    + + S            S  T ++ S   S P E         +  
Sbjct: 402 TILVASSEASTTSTIPVDSKTFVTTASEASSSPTTAEDTSIATSTPSEGSTPLTSMPVST 461

Query: 448 KPVLSGEAAE----AVHSGTSVKSS--SGPFPPAPEGLTAPEIEPEGEST 491
            PV S EA+      V S T V +S  +   PP  E  + P   P   ST
Sbjct: 462 TPVASSEASNLSTTPVDSKTQVTTSTEASSSPPTAEVNSMPTSTPSEGST 511



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 89/462 (19%), Positives = 160/462 (34%), Gaps = 86/462 (18%)

Query: 71   SEGTTPQKKLEC---LKEPGKTSVESKVPTQME-----------KSTDTDEDNVTRTEYS 116
            SEG+TP  ++     +    +TS  S  P                ST  D  ++  + YS
Sbjct: 1038 SEGSTPLTRMPVSTTMVASSETSTLSTTPADTSTPVTTYSQASSSSTTADGTSMPTSTYS 1097

Query: 117  DKTTQFPSV---------------------YAVPGTEQTEAVGGLSSKPATPKTTTPPSS 155
            + +T   SV                      ++P T  TEA    SS P T + T+ P+S
Sbjct: 1098 EGSTPLTSVPVSTRLVVSSEASTLSTTPVDTSIPVTTSTEA----SSSPTTAEGTSIPTS 1153

Query: 156  PPPTAVSPEFAYVPADPAQLAAQMLGKVSSIHSDQSDVLMVDVATSMPVVIKEVPSSEAA 215
            PP    +P  A +P     + +     +S+   D    +      S P    EV S   +
Sbjct: 1154 PPSEGTTP-LASMPVSTTLVVSSEANTLSTTPVDSKTQVATSTEASSPPPTAEVTSMPTS 1212

Query: 216  EDVMVAAPLVCSGKVLEVQVVNQTSVHVDLGSQPKENEAEPSTASSVPLQDEQEPPAYDQ 275
                 + PL            +    H  + S      +     +S P+    E      
Sbjct: 1213 TPGERSTPL-----------TSMPVRHTPVASSEASTLSTSPVDTSTPVTTSAET---SS 1258

Query: 276  APEVTLQADIEVMSTVHISSVYNDVPVTEGVVYIEQLPEQIVIPFTDQVACLKENEQSKE 335
            +P       +   +T   S++   +PV+  +V   +    +  P   +   +  NE S  
Sbjct: 1259 SPTTAEGTSLPTSTTSEGSTLLTSIPVSTTLVTSPEASTLLTTPVDTKGPVVTSNEVS-- 1316

Query: 336  NEQSPRVSPKSVVEKTTSGMSKKSVESVKLAQLEENAKYSSVYMEAEATALLSDTSLKGQ 395
               SP  +  + +  +T    +  + S+ +         ++  + + A ++LS T +   
Sbjct: 1317 --SSPTPAEGTSMPTSTYSEGRTPLTSIPV---------NTTLVASSAISILSTTPVDNS 1365

Query: 396  PEVPAQLLDAEGAIKIGSEKSLHLEVEITSIVSDNTGQEESGENSVPQEMEGKPVLSGEA 455
              V                 S     E TS+ + N  +  +   S+P  +   PV+S EA
Sbjct: 1366 TPVTTST----------EACSSPTTSEGTSMPNSNPSEGTTPLTSIP--VSTTPVVSSEA 1413

Query: 456  ----AEAVHSGT--SVKSSSGPFPPAPEGLTAPEIEP-EGES 490
                A  V + T  +  + +   P   EG++ P   P EG++
Sbjct: 1414 STLSATPVDTSTPGTTSAEATSSPTTAEGISIPTSTPSEGKT 1455



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 107/439 (24%), Positives = 157/439 (35%), Gaps = 85/439 (19%)

Query: 72   EGTTPQKKLECLKEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGT 131
            EG+TP   L  + +     V S+  T      DT     T TE +   T      ++P +
Sbjct: 921  EGSTP---LTSMPDSTTPVVSSEARTLSATPVDTSTPVTTSTEATSSPTTAEGT-SIPTS 976

Query: 132  EQTEAVGGLSSKPA---------------------TPKTT-TPPSSPPPTAVSPEFAYVP 169
              +E    L+S P                      TP TT T  SSPPPTA   E   +P
Sbjct: 977  TPSEGTTPLTSTPVSHTLVANSEASTLSTTPVDSNTPLTTSTEASSPPPTA---EGTSMP 1033

Query: 170  ADPAQLAAQMLGKVSSIHSDQSDVLMVDVATSMPVVIKEVPSSEAAEDVMVAAPLVCSGK 229
                          +S  S+ S  L     T MPV    V SSE +   +   P   S  
Sbjct: 1034 --------------TSTPSEGSTPL-----TRMPVSTTMVASSETS--TLSTTPADTSTP 1072

Query: 230  VLEVQVVNQTSVHVDLGSQPKENEAEPST-ASSVPLQDEQEPPAYDQAPEVTLQADIEVM 288
            V      + +S   D  S P    +E ST  +SVP+           +  + + ++   +
Sbjct: 1073 VTTYSQASSSSTTADGTSMPTSTYSEGSTPLTSVPV-----------STRLVVSSEASTL 1121

Query: 289  STVHISSVYNDVPVTEGVVYIEQLPEQIVIPFTDQVACLKENEQSKENE--QSPRVSPKS 346
            ST  + +    +PVT          E    P T +   +  +  S+      S  VS   
Sbjct: 1122 STTPVDT---SIPVTTST-------EASSSPTTAEGTSIPTSPPSEGTTPLASMPVSTTL 1171

Query: 347  VVEKTTSGMSKKSVESVKLAQLEENAKYSSVYMEAEATALLSDTSLKGQPEVPAQLLDAE 406
            VV    + +S   V+S    Q+  + + SS    AE T++   TS  G+   P   +   
Sbjct: 1172 VVSSEANTLSTTPVDS--KTQVATSTEASSPPPTAEVTSM--PTSTPGERSTPLTSMPVR 1227

Query: 407  GAIKIGSEKSLHLEVEITSIVSDNTGQEESGE-NSVPQEMEGKPVLSGEAAEAVHSGTSV 465
                  SE S       TS V  +T    S E +S P   EG  + +   +E     TS+
Sbjct: 1228 HTPVASSEAS----TLSTSPVDTSTPVTTSAETSSSPTTAEGTSLPTSTTSEGSTLLTSI 1283

Query: 466  KSSSG--PFPPAPEGLTAP 482
              S+     P A   LT P
Sbjct: 1284 PVSTTLVTSPEASTLLTTP 1302



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 60/255 (23%), Positives = 90/255 (35%), Gaps = 57/255 (22%)

Query: 16   TLLEGISRAVLKTNPSNINQFAAAYFQELTMYRGNTTMDIKDLVKQFHQIKVEKWSEGTT 75
            T++     + L T P++ +     Y Q      G++     D       +    +SEG+T
Sbjct: 2348 TMVASFETSTLSTTPADTSTPVTTYSQA-----GSSPTTADDT-----SMPTSTYSEGST 2397

Query: 76   PQKKLECLKEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTEQTE 135
            P   +     P    V S+  T      DT                     + P T  TE
Sbjct: 2398 PLTSVPVSTMP---VVSSEASTHSTTPVDT---------------------STPVTTSTE 2433

Query: 136  AVGGLSSKPATPKTTTPPSSPPPTAVSPEFAYVPADPAQLAAQMLGKVSSIHSDQSDVLM 195
            A    SS P T + T+ P+SPP    +P  A +P     + +   G +S+          
Sbjct: 2434 A----SSSPTTAEGTSIPTSPPSEGTTP-LASMPVSTTPVVSSEAGTLST--------TP 2480

Query: 196  VDVATSMPVVIKEVPSSEAAEDVMVAAPLVCSGKVLEVQVVNQTSVHVDLGSQPKENEAE 255
            VD +T M    +   S   AED++V       G  L       TS+ V   S       E
Sbjct: 2481 VDTSTPMTTSTEASSSPTTAEDIVVPISTASEGSTL------LTSIPV---STTPVASPE 2531

Query: 256  PSTASSVPLQDEQEP 270
             ST S+ P+ D   P
Sbjct: 2532 ASTLSTTPV-DSNSP 2545



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 80/364 (21%), Positives = 131/364 (35%), Gaps = 47/364 (12%)

Query: 127  AVPGTEQTEAVGGLSSKPATPKTTTPPSSPPPTAVSPEFAYVPADPAQLAAQMLGKVSSI 186
            ++P T  TEA    SS P T + T+ P+S P    +P    +P +   +A+   G +S+ 
Sbjct: 2779 SIPVTTSTEA----SSSPTTAEVTSMPTSTPSETSTP-LTSMPVNHTPVASSEAGTLST- 2832

Query: 187  HSDQSDVLMVDVATSMPVVIKEVPSSEAAEDVMVAAPLVCSGKVLEVQVVNQTSVHVDLG 246
                     VD +T +    K   S   AE ++V       G  L   +   T+    + 
Sbjct: 2833 -------TPVDTSTPVTTSTKASSSPTTAEGIVVPISTASEGSTLLTSIPVSTT---PVA 2882

Query: 247  SQPKENEAEPSTASSVPLQDEQE---PPAYDQAPEVTLQADIEVMSTVHISSVYNDVPVT 303
            S      +     +S+P+    E    P   +   + +    EV ST   S + + VPV 
Sbjct: 2883 SSEASTLSTTPVDTSIPVTTSTEGSSSPTTAEGTSMPISTPSEV-STPLTSILVSTVPVA 2941

Query: 304  -EGVVYIEQLPEQIVIPFTDQVACLKENEQSKENEQSPRVSPKSVVEKTTSGMSKKSVES 362
                  +   P     P T           S E   SP  +  + +  +T G  +  + S
Sbjct: 2942 GSEASTLSTTPVDTRTPVT----------TSAEASSSPTTAEGTSMPISTPGERRTPLTS 2991

Query: 363  VKLAQLEENAKYSSVYMEAEATALLSDTSLKGQPEVPAQLLDAEGA---IKIGSEKSLHL 419
            + ++ +   +  +S      A    + T +    E  +    AEG    I   SE S   
Sbjct: 2992 MSVSTMPVASSEASTLSRTPAD---TSTPVTTSTEASSSPTTAEGTGIPISTPSEGS--- 3045

Query: 420  EVEITSIVSDNTG---QEESGENSVPQEMEGKPVLSGEAAEAVHSGTSVKSSSGPFPPAP 476
               +TSI    T     E S  ++ P +     V S E +    S T  + +S P     
Sbjct: 3046 -TPLTSIPVSTTPVAIPEASTLSTTPVDSNSPVVTSTEVSS---SPTPAEGTSMPISTYS 3101

Query: 477  EGLT 480
            EG T
Sbjct: 3102 EGST 3105



 Score = 34.7 bits (78), Expect = 0.20
 Identities = 86/405 (21%), Positives = 140/405 (34%), Gaps = 66/405 (16%)

Query: 70   WSEGTTPQKKLECLKEPGKTS--VESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYA 127
            +SEG+TP   +     P  T+  V S+  T      DT     T TE S   T       
Sbjct: 1980 YSEGSTPLTSM-----PLSTTLVVSSEASTLSTTPVDTSTPATTSTEGSSSPT------- 2027

Query: 128  VPGTEQTEAVGGLSSKPATPKTTTPPSSPPPTA----VSPEFAYVPADPAQLAAQMLGKV 183
                      GG S + +TP   T P +  P +    VS E   +   P     Q+    
Sbjct: 2028 --------TAGGTSIQTSTPSERTTPLAGMPVSTTLVVSSEGNTLSTTPVDSKTQVTNST 2079

Query: 184  SSIHSDQSDVLMVDVA---------TSMPVVIKEVPSSEAAEDVMVAAPLVCSGKVLEVQ 234
             +  S  ++   + ++         TS+P+    V S EA+   +   P+  +  V+   
Sbjct: 2080 EASSSATAEGSSMTISAPSEGSPLLTSIPLSTTPVASPEAS--TLSTTPVDSNSPVI--- 2134

Query: 235  VVNQTSVHVDLGSQPKENEAEPSTASSVPLQDEQEPPAYDQAPEVTLQADIEVMSTVHIS 294
                TS  V     P E      T+       ++  P        T+ A    +ST+  +
Sbjct: 2135 ----TSTEVSSSPIPTE-----GTSMQTSTYSDRRTPLTSMPVSTTVVAS-SAISTLSTT 2184

Query: 295  SVYNDVPVTEGVVYIEQLPEQIVIPFTDQVACLKENEQSKENE--QSPRVSPKSVVEKTT 352
             V    PVT          E    P T +   +  +  S+ +    S  VS   VV    
Sbjct: 2185 PVDTSTPVTNST-------EARSSPTTSEGTSMPTSTPSEGSTPFTSMPVSTMPVVTSEA 2237

Query: 353  SGMSKKSVESVKLAQLEENAKYSSVYMEAEATALLSDTSLKGQPEVPAQLLDAEGAIKIG 412
            S +S   V++     +  + + +S    AE T++ + T  +G    P   +     +   
Sbjct: 2238 STLSATPVDT--STPVTTSTEATSSPTTAEGTSIPTSTLSEG--TTPLTSIPVSHTLVAN 2293

Query: 413  SEKSLHLEVEITSIVSDNTGQEESGENSVPQEMEGKPVLSGEAAE 457
            SE S      + S     T  E S   S P   EG  + +  ++E
Sbjct: 2294 SEVSTLSTTPVDSNTPFTTSTEAS---SPPPTAEGTSMPTSTSSE 2335



 Score = 34.7 bits (78), Expect = 0.20
 Identities = 91/419 (21%), Positives = 145/419 (34%), Gaps = 56/419 (13%)

Query: 86   PGKTSVESKVP-TQMEKSTD---TDEDNVTRTEYSDKTTQFPSVYAVPGTEQTEAVGGLS 141
            P  T  E   P T M  ST    + ED+       D +T        P T  TEA     
Sbjct: 3155 PTSTPSEGSTPLTYMPVSTMLVVSSEDSTLSATPVDTST--------PVTTSTEA----- 3201

Query: 142  SKPATPKTTTPPSSPPPTAVSPEFAYVPADPAQLAAQMLGKVSSIHSDQSDVLMVDVATS 201
            +   T + T+ P+S P   ++P    VP     +A+     +S+   D +  L      S
Sbjct: 3202 TSSTTAEGTSIPTSTPSEGMTP-LTSVPVSNTPVASSEASILSTTPVDSNTPLTTSTEAS 3260

Query: 202  MPVVIKEVPSSEAAEDVMVAAPLVCSGKVLEVQVVNQTSVHVDLGSQPKENEAEPST--- 258
                  E  S   +     + PL            ++TS    L + P +     +T   
Sbjct: 3261 SSPPTAEGTSMPTSTPSEGSTPLTSMPVSTTTVASSETST---LSTTPADTSTPVTTYSQ 3317

Query: 259  -ASSVPLQDEQEPPAYDQAPEVTLQADIEVMSTVHISSVYNDVPVT--EGVVYIEQLPEQ 315
             +SS P+ D    P    +   T   ++   +T  +SS  + +  T  +    +    E 
Sbjct: 3318 ASSSPPIADGTSMPTSTYSEGSTPLTNMSFSTTPVVSSEASTLSTTPVDTSTPVTTSTEA 3377

Query: 316  IVIPFTDQVACLKENEQSKENE--QSPRVSPKSVVEKTTSGMSKKSVESVKLAQLEENAK 373
             + P T +   +  +  S+      S  VS   VV    + +S   V+S  L      A 
Sbjct: 3378 SLSPTTAEGTSIPTSSPSEGTTPLASMPVSTTPVVSSEVNTLSTTPVDSNTLVTTSTEAS 3437

Query: 374  YSSVYMEAEATALLSDTSLKGQPEVPAQLLDAEGAIKIGSEKS------LHLEVEITSIV 427
             S     AE T+L + T+ +G    P  ++         SE S      +     +T+  
Sbjct: 3438 SSPTI--AEGTSLPTSTTSEG--STPLSIMPLSTTPVASSEASTLSTTPVDTSTPVTTSS 3493

Query: 428  SDNTGQEESGENSVPQEMEGK-------------PVLSGEAA----EAVHSGTSVKSSS 469
              N+    +   S+P    G+             PV S EA+      V S T V SSS
Sbjct: 3494 PTNSSPTTAEVTSMPTSTAGEGSTPLTNMPVSTTPVASSEASTLSTTPVDSNTFVTSSS 3552



 Score = 34.7 bits (78), Expect = 0.20
 Identities = 22/63 (34%), Positives = 29/63 (46%), Gaps = 4/63 (6%)

Query: 93   SKVPTQMEKSTDTDEDNVT----RTEYSDKTTQFPSVYAVPGTEQTEAVGGLSSKPATPK 148
            S  PT    ST  + + VT    RT+ S +TT FP+V        T      +S P  P+
Sbjct: 4072 STPPTTSASSTTVNPEAVTTMTTRTKPSTRTTSFPTVTTTAVPTNTTIKSNPTSTPTVPR 4131

Query: 149  TTT 151
            TTT
Sbjct: 4132 TTT 4134



 Score = 34.3 bits (77), Expect = 0.27
 Identities = 96/427 (22%), Positives = 145/427 (33%), Gaps = 60/427 (14%)

Query: 89   TSVESKVP----TQMEKSTDTDEDNV----TRTEYSDKTTQFPSVYAVPGTEQTEAVGGL 140
            T V+S  P    T+   S+ T E       T TE S   T  P    +  + +   +   
Sbjct: 652  TPVDSNTPVTTSTEATSSSTTAEGTSMPTSTYTEGSTPLTSMPVNTTLVASSEASTLSTT 711

Query: 141  SSKPATPKTTTPPSSPPPTAVSPEFAYVPADPAQLAAQMLGKVSSIHSDQSDVLMVDVAT 200
                +TP TT+  +S  PT          AD A +        +S  S+ S  L     T
Sbjct: 712  PVDTSTPVTTSTEASSSPTT---------ADGASMP-------TSTPSEGSTPL-----T 750

Query: 201  SMPVVIKEVPSSEAAEDVMVAAPLVCSGKVLEVQVVNQTSVHVDLGSQPKENEAEPS--- 257
            SMPV    + SSEA+   +   PL  S  +      + +    +  S P    +E S   
Sbjct: 751  SMPVSKTLLTSSEAS--TLSTTPLDTSTHITTSTEASCSPTTTEGTSMPISTPSEGSPLL 808

Query: 258  TASSVPLQDEQEPPA-------YDQAPEVTLQADIEVMSTVHISSVYNDVPVTEGVVYIE 310
            T+  V +     P A        D    VT   ++    T    +       +EG   + 
Sbjct: 809  TSIPVSITPVTSPEASTLSTTPVDSNSPVTTSTEVSSSPTPAEGTSMPTSTYSEGRTPLT 868

Query: 311  QLPEQIVIPFTDQVACLK----ENEQSKENEQSPRVSPKSVVEKTTSGMSKKSVESVKLA 366
             +P    +  T  ++ L     +      N    R SP +  E T+   S     S  L 
Sbjct: 869  SMPVSTTLVATSAISTLSTTPVDTSTPVTNSTEARSSP-TTSEGTSMPTSTPGEGSTPLT 927

Query: 367  QLEENAK--YSSVYMEAEATALLSDTSLKGQPEVPAQLLDAEGAIKIGSEKSLHLEVEIT 424
             + ++     SS      AT + + T +    E  +    AEG     S  S     E T
Sbjct: 928  SMPDSTTPVVSSEARTLSATPVDTSTPVTTSTEATSSPTTAEGTSIPTSTPS-----EGT 982

Query: 425  SIVSDNTGQEESGENSVPQEMEGKPVLSGEAAEAVHSGTSVKSSSGPFPPAPEGLTAPEI 484
            + ++          NS    +   PV S          TS ++SS   PP  EG + P  
Sbjct: 983  TPLTSTPVSHTLVANSEASTLSTTPVDSNTPLT-----TSTEASSP--PPTAEGTSMPTS 1035

Query: 485  EPEGEST 491
             P   ST
Sbjct: 1036 TPSEGST 1042



 Score = 34.3 bits (77), Expect = 0.27
 Identities = 74/355 (20%), Positives = 124/355 (34%), Gaps = 44/355 (12%)

Query: 71   SEGTTPQKKLECLKEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPG 130
            SEGTTP   +     P    V S+V T      D++    T TE S   T      ++P 
Sbjct: 3395 SEGTTPLASMPVSTTP---VVSSEVNTLSTTPVDSNTLVTTSTEASSSPTIAEGT-SLPT 3450

Query: 131  TEQTEAVGGLSSKP---------------ATP-KTTTPPSSPPPTAVSPEFAYVPADPAQ 174
            +  +E    LS  P                TP  T+TP ++  PT  SP  A V + P  
Sbjct: 3451 STTSEGSTPLSIMPLSTTPVASSEASTLSTTPVDTSTPVTTSSPTNSSPTTAEVTSMPTS 3510

Query: 175  LAAQ-------MLGKVSSIHSDQSDVLMVDVATSMPVVIKEVPSSEAAEDVMVAAPLVCS 227
             A +       M    + + S ++  L      S   V     +S +   + V    + +
Sbjct: 3511 TAGEGSTPLTNMPVSTTPVASSEASTLSTTPVDSNTFVTSSSQASSSPATLQVTTMRMST 3570

Query: 228  ----GKVLEVQVVNQTSVHVDLGSQPKENEAEPSTASSVPLQDEQEPPAYDQAPEVTLQA 283
                   L   +++ T V     S P    + PS   S P+    +  +    PEV    
Sbjct: 3571 PSEGSSSLTTMLLSSTYVTSSEASTP----STPSVDRSTPVTTSTQSNSTPTPPEV---I 3623

Query: 284  DIEVMSTVHISSVYNDVPVTEGVVYIEQLPEQIVIPFTDQVACLKENEQSK-----ENEQ 338
             + + +   +S+    +PV+   V I +      +P       +   + S      E   
Sbjct: 3624 TLPMSTPSEVSTPLTIMPVSTTSVTISEAGTASTLPVDTSTPVITSTQVSSSPVTPEGTT 3683

Query: 339  SPRVSP-KSVVEKTTSGMSKKSVESVKLAQLEENAKYSSVYMEAEATALLSDTSL 392
             P  +P +     TT  +S   V S + + L   +  +S  +     A+ S  +L
Sbjct: 3684 MPIWTPSEGSTPLTTMPVSTTRVTSSEGSTLSTPSVVTSTPVTTSTEAISSSATL 3738



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 94/448 (20%), Positives = 152/448 (33%), Gaps = 66/448 (14%)

Query: 70   WSEGTTPQKKLECLKEP---------GKTSVESKVPTQMEKST--------DTDEDNVTR 112
            +SEG+TP + +    +P           T V++ +P      T        DT     T 
Sbjct: 2569 YSEGSTPLRSMPVSTKPLASSEASTLSTTPVDTSIPVTTSTETSSSPTTAKDTSMPISTP 2628

Query: 113  TEYSDKTTQF-----PSVYAVPGTEQTEAVG---------GLSSKPATPKTTTPPSSPPP 158
            +E S   T       P   +   T  T  V          G SS P T + ++ P+S P 
Sbjct: 2629 SEVSTSLTSILVSTMPVASSEASTLSTTPVDTRTLVTTSTGTSSSPTTAEGSSMPTSTPG 2688

Query: 159  TAVSPEFAYVPADPAQLAAQMLGKVSSIHSDQSDVLMVDVATSMPVVIKEVPSSE--AAE 216
               +P           L   ++      +S+ S +    V TS PV      SS    AE
Sbjct: 2689 ERSTP-----------LTNILVSTTLLANSEASTLSTTPVDTSTPVTTSAEASSSPTTAE 2737

Query: 217  DVMVAAPLVCSGKVLEVQVVNQTSVHVDLGSQPKENEAEPSTASSVPLQDEQEPPAYDQA 276
               +       G      ++  T   + + S      +  +  +S+P+    E  +    
Sbjct: 2738 GTSMRISTPSDGSTPLTSILVST---LPVASSEASTVSTTAVDTSIPVTTSTEASSSPTT 2794

Query: 277  PEVTLQ--ADIEVMSTVHISSVYNDVPVTEGVV-YIEQLPEQIVIPFTDQVACLKENEQS 333
             EVT    +     ST   S   N  PV       +   P     P T           S
Sbjct: 2795 AEVTSMPTSTPSETSTPLTSMPVNHTPVASSEAGTLSTTPVDTSTPVT----------TS 2844

Query: 334  KENEQSPRVSPKSVVEKTTSGMSKKSVESVKLAQLE-ENAKYSSVYMEAEATALLSDTSL 392
             +   SP  +   VV  +T+      + S+ ++     +++ S++      T++   TS 
Sbjct: 2845 TKASSSPTTAEGIVVPISTASEGSTLLTSIPVSTTPVASSEASTLSTTPVDTSIPVTTST 2904

Query: 393  KGQPEVPAQLLDAEGAIKIGSEKSLHLEVEITSIVSDNTGQEESGENSVPQEMEGKPVLS 452
            +G    P         I   SE S  L   + S V    G E S  ++ P +    PV +
Sbjct: 2905 EGSSS-PTTAEGTSMPISTPSEVSTPLTSILVSTV-PVAGSEASTLSTTPVDTR-TPVTT 2961

Query: 453  GEAAEAVHSGTSVKSSSGPFPPAPEGLT 480
              +AEA  S T+ + +S P     E  T
Sbjct: 2962 --SAEASSSPTTAEGTSMPISTPGERRT 2987



 Score = 30.8 bits (68), Expect = 2.9
 Identities = 93/426 (21%), Positives = 148/426 (34%), Gaps = 63/426 (14%)

Query: 71  SEGTTPQKKLECLKEPGKTSVESKVP-TQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVP 129
           +E ++     E    P  T  E   P T M  ST      V  +E S  +T  P   + P
Sbjct: 487 TEASSSPPTAEVNSMPTSTPSEGSTPLTSMSVSTMP----VASSEASTLSTT-PVDTSTP 541

Query: 130 GTEQTEAVGGLSSKPATPKTTTPPSSPPPTAVSPEFAYVPADPAQLAAQMLGKVSSIHSD 189
            T  +EA    SS   TP+ T+ P+S P    +P    +P     + +      S+  +D
Sbjct: 542 VTTSSEA----SSSSTTPEGTSIPTSTPSEGSTP-LTNMPVSTRLVVSSEASTTSTTPAD 596

Query: 190 QSDVLMVDVATSMPVVIKE---VPSSEAAE------DVMVAAPLVCSGKVLEVQ---VVN 237
            +  +      S      E   +P+S  +E       + V+  LV S +   +    V +
Sbjct: 597 SNTFVTTSSEASSSSTTAEGTSMPTSTYSERGTTITSMSVSTTLVASSEASTLSTTPVDS 656

Query: 238 QTSVHVDLGSQPKENEAEPSTASSVPLQDEQEPPAYDQAPEVTLQADIEVMSTVHISSVY 297
            T V     +      AE  T+       E   P        TL A  E  ST+  + V 
Sbjct: 657 NTPVTTSTEATSSSTTAE-GTSMPTSTYTEGSTPLTSMPVNTTLVASSEA-STLSTTPVD 714

Query: 298 NDVPVTEGVVYIEQLPEQIVIPFTDQVACLKENEQSKENEQSPRVSPKSVVEKTTSGMSK 357
              PVT          E    P T   A +  +  S+ +              T+  +SK
Sbjct: 715 TSTPVTTST-------EASSSPTTADGASMPTSTPSEGS-----------TPLTSMPVSK 756

Query: 358 KSVESVKLAQLEENAKYSSVYMEAEATALLSDTSLKGQP---EVPAQLLDAEGAIKIGSE 414
             + S + + L      +S ++     A  S T+ +G       P++          GS 
Sbjct: 757 TLLTSSEASTLSTTPLDTSTHITTSTEASCSPTTTEGTSMPISTPSE----------GSP 806

Query: 415 KSLHLEVEITSIVSDNTGQEESGENSVPQEMEGKPVLSGEAAEAVHSGTSVKSSSGPFPP 474
               + V IT +    T  E S  ++ P +    PV +  + E   S T  + +S P   
Sbjct: 807 LLTSIPVSITPV----TSPEASTLSTTPVD-SNSPVTT--STEVSSSPTPAEGTSMPTST 859

Query: 475 APEGLT 480
             EG T
Sbjct: 860 YSEGRT 865


>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
          Length = 2400

 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 64/284 (22%), Positives = 105/284 (36%), Gaps = 44/284 (15%)

Query: 244  DLGSQPKENEAEPSTAS-SVPLQDEQEPPAYD--QAPEVTLQADIEVMSTVHISSVYNDV 300
            D+ +   E EA+P +     P  + +  P  +  +APE   +A  E  S   + +   D 
Sbjct: 1873 DVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDE 1932

Query: 301  PVTEGV---------------------VYIEQLPEQIVIPFTDQVACLKENEQSKENEQS 339
            P +EG                      V   Q  E+   P ++ V  L+   +++E E  
Sbjct: 1933 PESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGE 1992

Query: 340  PRVSPKSVVEKTTSGMSKKS----------VESVKLAQLEENAKYSSVYMEAEATALLSD 389
             +   + V      G  +++          VE+   ++ EE  +      + E  A    
Sbjct: 1993 AQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPES 2052

Query: 390  TSLKGQPEVPAQLLDAEGAIKIGSEKSLHLEVEITSIVSDNTGQEESGENSVPQEMEGKP 449
              ++  PE   +  +AEG ++  +E   H E E      D   QE  GE     E    P
Sbjct: 2053 DGVEA-PEAEEEAQEAEGEVQ-EAEGEAHPESE------DVDAQEAEGEAQPESEGVEAP 2104

Query: 450  VLSGEAAEAVHSGTSVKSSSGPFPPAPEGLTAPEIEPEGESTAE 493
               GEA +A   G     + G   P  EG+ APE E E +  +E
Sbjct: 2105 EAEGEAQKA--EGIEAPETEGEAQPESEGIEAPEAEGEAQPESE 2146



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 91/406 (22%), Positives = 146/406 (35%), Gaps = 47/406 (11%)

Query: 92   ESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTEQTEAVGGLSSKPATPKTTT 151
            E +   + E     + +   + E  D  T        P +E  EA    + K A P+T +
Sbjct: 1864 EGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPE--AEKEAQPETES 1921

Query: 152  PPSSPPPTAVSPEFAYVPADPAQLAAQMLGKVSSIHSDQSDVLMVDVATSMPVVIKEVPS 211
              +        PE     A  A+ AAQ   +       +S+V               + S
Sbjct: 1922 VEALETEGEDEPESEGAEAQEAEEAAQ---EAEGQTQPESEV---------------IES 1963

Query: 212  SEAAEDVMVAAPLVCSGKVLEVQVVNQTSVHVDLGSQPKENEAEPSTASSVPLQDEQEPP 271
             EA E+   A P     + LEV+V  Q +   +  +QP+  + E   A     + E+E  
Sbjct: 1964 QEAEEE---AQPESEDVEALEVEVETQEA---EGEAQPESEDVEAPEAEGEMQEAEEEAQ 2017

Query: 272  AYDQAPEVTLQADIEVMSTVHISSVYNDVPVTEGVVYIEQLPEQIVIPFTDQVACLKENE 331
                  E   +++ E         V  +   TEG    E   + +  P  ++ A   E E
Sbjct: 2018 PESDGVEAQPKSEGE-----EAQEVEGETQKTEGDAQPES--DGVEAPEAEEEAQEAEGE 2070

Query: 332  -QSKENEQSPRVSPKSVVEKTTSGMSKKSVESVKLAQLEENAKYSSVYMEAEATALLSDT 390
             Q  E E  P    + V  +   G ++   E V+  + E  A+      +AE      +T
Sbjct: 2071 VQEAEGEAHPE--SEDVDAQEAEGEAQPESEGVEAPEAEGEAQ------KAEGIEA-PET 2121

Query: 391  SLKGQPEVPA-QLLDAEGAIKIGSEKSLHLEVEITSIVSDNTGQEESGENSVPQEMEG-- 447
              + QPE    +  +AEG  +  SE     + E  +       + +  E     E+EG  
Sbjct: 2122 EGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVE 2181

Query: 448  KPVLSGEAAEAVHSGTSVKSSSGPFPPAPEGLTAPEIEPEGESTAE 493
             P   GEA +    G     + G   P  EG+ APE E E +   E
Sbjct: 2182 APEAEGEA-QPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPE 2226



 Score = 37.7 bits (86), Expect = 0.024
 Identities = 41/168 (24%), Positives = 67/168 (39%), Gaps = 9/168 (5%)

Query: 332  QSKENEQSPRVSPKSVVEKTTSGMSKKSVESVKLAQLEENAKYSSVYMEAEATALLSDTS 391
            Q  E    P +S    V++   G   + +   K  +L E A+  ++  E E     S+TS
Sbjct: 1724 QGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGE-AEGDAMAQEREGKTHNSETS 1782

Query: 392  LK---GQPEVPAQLLDAEGAIKIGSEKSLH---LEVEITSIVSDNTGQEESGENSVPQEM 445
                 G+ E   + +   G  + G + S H   L+ E  +    + GQ +  E     E 
Sbjct: 1783 AGSELGEAEQEGEGISERG--ETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEA 1840

Query: 446  EGKPVLSGEAAEAVHSGTSVKSSSGPFPPAPEGLTAPEIEPEGESTAE 493
            EG+     E  EA  +    + + G   P  E + APE E E +  +E
Sbjct: 1841 EGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESE 1888


>gi|8394343 sperm autoantigenic protein 17 [Homo sapiens]
          Length = 151

 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 25/77 (32%), Positives = 40/77 (51%), Gaps = 7/77 (9%)

Query: 10 VPYGLKTLLEGISRAVLKTNPSNINQFAAAYFQELTMYRGNTTMD-------IKDLVKQF 62
          +P G   LLEG++R +L+  P NI  FAAAYF+ L   R  T  D       ++D     
Sbjct: 12 IPQGFGNLLEGLTREILREQPDNIPAFAAAYFESLLEKREKTNFDPAEWGSKVEDRFYNN 71

Query: 63 HQIKVEKWSEGTTPQKK 79
          H  + ++  E + P+++
Sbjct: 72 HAFEEQEPPEKSDPKQE 88


>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
          Length = 2468

 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 104/455 (22%), Positives = 149/455 (32%), Gaps = 77/455 (16%)

Query: 72  EGTTPQKKLECLKEPGKTSVE--SKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVP 129
           EG    K L+ LK+P  T  +   +VPT + K T   +   +R          PS     
Sbjct: 500 EGLEKLKHLDFLKQPLATQKDLTGQVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRK 559

Query: 130 GTEQTEAVGGLSSKPATPKTTTPPS-SPPPTAVSPEFAYVPADPAQLAAQMLGKVSSIHS 188
                       SK  TP+ T       PP   S E   V  D                 
Sbjct: 560 -----------ESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKP--------------- 593

Query: 189 DQSDVLMVDVATSMPVVIKEVPSSEA-----AEDVMVAAPLVCSGKVLEVQVVNQTSVHV 243
                  +   T   V  KEVPS E      AE     A  V      E  V  +T V  
Sbjct: 594 -------IKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKP 646

Query: 244 DLGSQPKENEAEP--STASSVPLQDEQEPPAYDQAPEVTLQADIEVMSTVHISSVYNDVP 301
           +   + KE   +         P++ E++P   +   EV  +   E         V  + P
Sbjct: 647 EDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPK-KEVKKETP 705

Query: 302 VTEGVVYIEQLPEQIVIPFTDQVACLKENEQSKENEQSPRVSPKSVVEKTTSGMSKKSVE 361
             E    +++  ++ V          +E E  KE ++ P+ + KS      S   K +  
Sbjct: 706 PKEVKKEVKKEEKKEVKK--------EEKEPKKEIKKLPKDAKKS--STPLSEAKKPAAL 755

Query: 362 SVKLAQLEENAKYSSV------------YMEAEATALLSDTSLKGQPEVPAQLLDAEGAI 409
             K+ + EE+ K  SV             ++ E  A  +  +  G     A ++ A G  
Sbjct: 756 KPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIA 815

Query: 410 KIGSEKSLHLEVEITSIVSDNTGQ-EESGENSVPQEMEGKPVLS----------GEAAEA 458
            IG  K L  E  + S   D T   EE     V    + KP L            E  EA
Sbjct: 816 AIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEA 875

Query: 459 VHSGTSVKSSSGPFPPAPEGLTAPEIEPEGESTAE 493
                  + + GP     EG+T  E E E E T E
Sbjct: 876 YVIQKEREVTKGPAESPDEGITTTEGEGECEQTPE 910



 Score = 35.4 bits (80), Expect = 0.12
 Identities = 80/417 (19%), Positives = 150/417 (35%), Gaps = 48/417 (11%)

Query: 99   MEKSTDTDEDNVTRTEYSDKTTQFPSV--YAVPGTEQTEAV-------------GGLS-- 141
            +EK+T T E+     + S+KTT  P V  Y+   TE++  +             GG +  
Sbjct: 1943 IEKTTRTPEEGGYSYDISEKTTSPPEVSGYSYEKTERSRRLLDDISNGYDDSEDGGHTLG 2002

Query: 142  ----SKPATPKTTTPPSSPPPTAVSPEFAYVPADPAQLAAQMLGKVSSIHSDQSDVLMVD 197
                S   T K T+ P S   +  +        D +    +   K++   + Q+     +
Sbjct: 2003 DPSYSYETTEKITSFPESEGYSYETSTKTTRTPDTSTYCYETAEKIT--RTPQASTYSYE 2060

Query: 198  VATSMPVVIKEVPSSEAAEDVMVAAPLVCSGK----VLEVQVVNQTSVHVDLGSQPKENE 253
             +       K+ P SEA +DV +     C  K     L    +N   +      +P E  
Sbjct: 2061 TSDLCYTAEKKSP-SEARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEWFASEEPTEES 2119

Query: 254  AEPSTASS---VPLQDEQEPPAYDQAPEVTLQADIEVMSTVHISSVYNDVPVTEGVVYIE 310
             +P T S     P   +Q+    D+ P  ++       +   +     + P       I+
Sbjct: 2120 EKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECPSITADANID 2179

Query: 311  QLPEQIVIPFTDQVACLKENEQS----KENEQSPRVSPKSVVEKTTSGMSKKSVESVKLA 366
               E   IP TD+    K  +      ++   SPR    S+V+     + +   +++K  
Sbjct: 2180 SEDESETIP-TDKTVTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKALK-K 2237

Query: 367  QLEENAKYSSVYMEAEATALLSDTSLKGQP----EVPAQLLDAEGAIKIGSEKSLHLEVE 422
             L+E  K      + ++++ +  +  K +P      PA L   E + K+    S   +  
Sbjct: 2238 DLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGL--KESSDKVSRVASPKKKES 2295

Query: 423  ITSIVSDNTGQEESGENSVPQEMEGKPVLSGEAAEAVHS-----GTSVKSSSGPFPP 474
            +       T  E        ++ E K   +  A+++  +     GT+  + S   PP
Sbjct: 2296 VEKAAKPTTTPEVKAARGEEKDKETKNAANASASKSAKTATAGPGTTKTTKSSAVPP 2352



 Score = 32.0 bits (71), Expect = 1.3
 Identities = 21/69 (30%), Positives = 29/69 (42%), Gaps = 5/69 (7%)

Query: 101  KSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTEQTEAVGGLSSKPATPKTTTPPSSPPPTA 160
            K T T E    R E  DK T+  +  +   + +T   G     P T KTT   + PP   
Sbjct: 2301 KPTTTPEVKAARGEEKDKETKNAANASASKSAKTATAG-----PGTTKTTKSSAVPPGLP 2355

Query: 161  VSPEFAYVP 169
            V  +  Y+P
Sbjct: 2356 VYLDLCYIP 2364


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 92/450 (20%), Positives = 154/450 (34%), Gaps = 45/450 (10%)

Query: 59  VKQFHQIKVEKWSEGTTPQKKLECLKEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDK 118
           VK   + K     E  +P +     KE  K+  E K P + +     +  +    +  +K
Sbjct: 544 VKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEK 603

Query: 119 TTQFPSVYAVPGTEQTEAVGGLSSKPATPKTTTPPSSP-PPTAVSPEFAYVPADPAQLAA 177
                   A    E    V   +  PA  K+     SP    A SPE A  P        
Sbjct: 604 AKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSP-------- 655

Query: 178 QMLGKVSSIHSDQSDVLMVDVATSMPVVIKEVPSSEAAEDVMVAAPLVCSGKVLE--VQV 235
               +     S +     V      P   K    +EA       +P+    K  E     
Sbjct: 656 ----EKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSP 711

Query: 236 VNQTSVHVDLGSQPKENEAEPSTASSVPLQDEQEPPAYDQAPEVTLQADIEVMSTVHISS 295
           V + +   +    P + EA+    +  P+++E + P   ++PE           T+ + S
Sbjct: 712 VKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKA--------KTLDVKS 763

Query: 296 VYNDVPVTEGV-VYIEQLPEQIVIPFTDQV-------ACLKENEQSKENEQSPRVSPKSV 347
                P  E      ++ PE+   P  ++V       + LKE+ ++ E E   +   KS 
Sbjct: 764 PEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSP 823

Query: 348 VEKTTSGMSKKSVESVKLAQLEENAKYSSVYMEAEATALLSDTSLKGQPEVPAQLLDAEG 407
           V++       K  E  K A+ EE A  +    E +      D+  +  P+  A     E 
Sbjct: 824 VKEEEKPQEVKVKEPPKKAE-EEKAPATPKTEEKK------DSKKEEAPKKEAPKPKVEE 876

Query: 408 AIKIGSEKSLHLEVEITSIVSDNTGQEESGENSVPQEME----GKPVLSGEAAEAVHSGT 463
             +   EK    +VE     +++  +  + E   P ++E     KP    E A+      
Sbjct: 877 KKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDA 936

Query: 464 SVKSSSGPFPPAPEGLTAPEIEPEGESTAE 493
             K    P  PA +   APE +   E  A+
Sbjct: 937 KAKE---PSKPAEKKEAAPEKKDTKEEKAK 963



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 76/352 (21%), Positives = 129/352 (36%), Gaps = 39/352 (11%)

Query: 55  IKDLVKQFHQIKVEKWSEGTTPQKKLECLKEPGKTSVESKVPTQME-KSTDTDEDNVTRT 113
           +K   K   + K    +E  +P+K    +KE  K+  ++K P + E KS +  +  V   
Sbjct: 670 VKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEE 729

Query: 114 EYSDKTTQFPSVYAVPGTEQTEAVGGLSSKPATPKTTTPPSSPPPTAVSPEFAYVPAD-- 171
             + +  + P         + EA     +K      T    SP     + E A  PAD  
Sbjct: 730 AKTPEKAKSP--------VKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKF 781

Query: 172 PAQLAAQMLGKVSSIHSDQSDVLMVDVATSMPVVIKEVPSSEAAEDVMVAAPLVCSGKVL 231
           P +  + +  +V S    +S +     A       KE+P  E      V +P+    K  
Sbjct: 782 PEKAKSPVKEEVKSPEKAKSPLKEDAKAPE-----KEIPKKEE-----VKSPVKEEEKPQ 831

Query: 232 EVQVVN--QTSVHVDLGSQPKENEAEPSTASSVPLQDEQEPPAYD-QAPEVTLQADIEVM 288
           EV+V    + +      + PK  E + S     P ++  +P   + + P V    + +V 
Sbjct: 832 EVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVE 891

Query: 289 STVHISSVYNDVPVTEGVVYIEQLPEQIVIPFTDQVACLKENEQSKENEQSPRVSPKSVV 348
           +    +     VP  E     ++ P ++ +         KE+ + KE  +  +  P    
Sbjct: 892 AKKEEAEDKKKVPTPE-----KEAPAKVEV---------KEDAKPKEKTEVAKKEPDDAK 937

Query: 349 EKTTS-GMSKKSVESVKLAQLEENAKYSSVYMEAEATALLSDTSLKGQPEVP 399
            K  S    KK     K    EE AK      + EA A   D +L  +P  P
Sbjct: 938 AKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKP 989



 Score = 37.4 bits (85), Expect = 0.031
 Identities = 66/336 (19%), Positives = 124/336 (36%), Gaps = 35/336 (10%)

Query: 156 PPPTAVSPEFAYVPADPAQLAAQMLGKVSSIHSDQSDVLMVDVATSMPVVIKEVPSSEAA 215
           P P ++      +P+    +  +   K+  +   + + ++V+  T    V +EV   E  
Sbjct: 417 PIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEK 476

Query: 216 EDVMVAAPLVCSGKVLEVQVVNQTSVHVDLGSQPKENEAEPSTASSVPLQDEQEPPAYDQ 275
           E           G+  E +   +     +  S P E  A P   +  P+++E + PA  +
Sbjct: 477 EAKEEEGKEEEGGEEEEAEGGEE-----ETKSPPAEEAASPEKEAKSPVKEEAKSPAEAK 531

Query: 276 APEVTLQADIEVMSTVHISSVYNDVPVTEGVVYIEQLPEQIVIPFTDQVACLKENEQSKE 335
           +PE       E  S   + S                 PE+   P  ++    K   ++K 
Sbjct: 532 SPEKE-----EAKSPAEVKS-----------------PEKAKSPAKEEA---KSPPEAKS 566

Query: 336 NEQSPRVSPKSVVE-KTTSGMSKKSVESVKLAQLEENAKYSSVYMEAEATALLSDTSLKG 394
            E+    SP  V   +     +K+  +S   A+  E AK S V  EA++ A  + + +K 
Sbjct: 567 PEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAK-SPVKEEAKSPA-EAKSPVKE 624

Query: 395 QPEVPAQLLDAEGAIKIGSEKSLHLEVEITSIVSDNTGQEESGENSVPQEMEGKPVLSGE 454
           + + PA++   E A     E++   E +  S   +     E  ++ V  E +        
Sbjct: 625 EAKSPAEVKSPEKAKSPTKEEAKSPE-KAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSP 683

Query: 455 AAEAVHSGTSVKSSSGPFPPAPEGLTAPEIEPEGES 490
                 S    KS       +PE   +P ++ E +S
Sbjct: 684 VKAEAKSPEKAKSPVKEEAKSPEKAKSP-VKEEAKS 718


>gi|10092601 eukaryotic translation initiation factor 4 gamma, 3
           [Homo sapiens]
          Length = 1585

 Score = 41.6 bits (96), Expect = 0.002
 Identities = 78/404 (19%), Positives = 135/404 (33%), Gaps = 83/404 (20%)

Query: 131 TEQTEAVGGLSSKPATPKTTTPPSSPPPTAVSPEFAYVPADPAQLAAQMLGKVSSIHSDQ 190
           T +T A+  ++  P  P  TT  S    T  +P  + + + P    A  +     + S +
Sbjct: 250 TSETTAIVSIAELPLPPSPTTVSSVARSTIAAPTSSALSSQPIFTTA--IDDRCELSSPR 307

Query: 191 SDVLMVDVATSMPVVIKEVPSSEAAEDVMVAA--------PLVCSGKVLE---------- 232
            D + +   TS       +P++E  +D+            PLV S  ++           
Sbjct: 308 EDTIPIPSLTSCTETSDPLPTNENDDDICKKPCSVAPNDIPLVSSTNLINEINGVSEKLS 367

Query: 233 -----VQVVNQTSVHVDLGSQPKENEAE------------PSTASSVPLQDEQEPPAYDQ 275
                V++V Q  + + L  +  EN  E            PST  S P      P +   
Sbjct: 368 ATESIVEIVKQEVLPLTLELEILENPPEEMKLECIPAPITPSTVPSFPPTPPTPPASPPH 427

Query: 276 APEVTLQADIEVMSTVHISSVYNDVPVTEGVVYIEQLPEQIVIPFTDQVACLKENEQSKE 335
            P +   A   V S     +V   +   E +                   CL E+ +  +
Sbjct: 428 TPVIVPAAATTVSSPSAAITVQRVLEEDESIR-----------------TCLSEDAKEIQ 470

Query: 336 NEQSPRVSPKSVVEKTTSGMSKKSVESVKLAQLEENAKYSSVYMEAEATALLSDTSLKGQ 395
           N+          +E    G +++ ++S  L     N++ S V  +   T   +    K +
Sbjct: 471 NK----------IEVEADGQTEEILDSQNL-----NSRRSPVPAQIAITVPKTWKKPKDR 515

Query: 396 PEVPAQLLDAEGAIKIGSEKSLHLEVEIT--------------SIVSDNTGQEESGENSV 441
                ++L+AE  +K   E S+   +E                S +      EE+GE + 
Sbjct: 516 TRTTEEMLEAELELKAEEELSIDKVLESEQDKMSQGFHPERDPSDLKKVKAVEENGEEAE 575

Query: 442 PQEMEGKPVLSGEAAEAVHSGTSVKSSSGPFPPAPEGLTAPEIE 485
           P     + V  GE  +A    T        FP  PE     + E
Sbjct: 576 PVRNGAESVSEGEGIDANSGSTDSSGDGVTFPFKPESWKPTDTE 619


>gi|19923559 EMSY protein [Homo sapiens]
          Length = 1322

 Score = 40.0 bits (92), Expect = 0.005
 Identities = 61/263 (23%), Positives = 104/263 (39%), Gaps = 23/263 (8%)

Query: 141 SSKPATPKTTTPPSSPPPTAVSPEFAYVPADPAQLAAQMLGKVSSIHSDQSDVL-----M 195
           +S  +TP +T  PS    T  SP  A   ++   L +     V S+     D        
Sbjct: 147 TSTTSTPTSTPVPSGSIATVKSPRPASPASNVVVLPSGSTVYVKSVSCSDEDEKPRKRRR 206

Query: 196 VDVATSMPVVIKEVPSSEAAEDVMVAAPLVCSGKVLEV--QVVNQTSVHVDLGSQPKENE 253
            + ++S PVV+KEVP +       +  P+  S K+  +   + N    H+   S  K   
Sbjct: 207 TNSSSSSPVVLKEVPKAVVPVSKTITVPVSGSPKMSNIMQSIANSLPPHM---SPVKITF 263

Query: 254 AEPSTASSVPLQDEQEPPAYDQAPEVTLQADIEVMSTVHISSVYNDVPVTEGVVYIEQLP 313
            +PST ++      Q+      +P  T   +I  +S  H  +    +  T  +    Q P
Sbjct: 264 TKPSTQTT--NTTTQKVIIVTTSPSSTFVPNI--LSKSHNYAAVTKLVPTSVIASTTQKP 319

Query: 314 EQIVIPFTDQVACLKENEQSKENEQSPRVSPKSVVEKTTSGMSKKSVESVKLAQLEENAK 373
             ++   T   + L  N  S  +  +P   P +V    T+ +S  S  SV ++ + +   
Sbjct: 320 PVVI---TASQSSLVSNSSSGSSSSTPSPIPNTVA--VTAVVS--STPSVVMSTVAQGVS 372

Query: 374 YSSVYMEAEATALLSDTSLKGQP 396
            S++ M   +T L S  SL   P
Sbjct: 373 TSAIKM--ASTRLPSPKSLVSAP 393


>gi|71044479 death inducer-obliterator 1 isoform c [Homo sapiens]
          Length = 2240

 Score = 39.7 bits (91), Expect = 0.006
 Identities = 93/431 (21%), Positives = 145/431 (33%), Gaps = 77/431 (17%)

Query: 122  FPSVYAVPGTEQTEAVGGLSSKPATPKTTTPPSSPP-----------------PTAVSPE 164
            +P V  VP +E+  +   L S  A   TT P S PP                 P A SP 
Sbjct: 1228 YPKVATVPQSEKKPSKYPLCSADAAVSTTPPGSPPPPPPLPEPPVLKVLSSLKPAAPSPA 1287

Query: 165  FAYVPADPAQLAAQMLGKVSSIHSDQSDVLMVDV---ATSMPVVIKEVPSSEA------- 214
             A   A  A  AA      +S  +   + ++  +     S     +E P S A       
Sbjct: 1288 TAATTAAAASTAASSTASSASKTASPLEHILQTLFGKKKSFDPSAREPPGSTAGLPQEPK 1347

Query: 215  --AEDVMVAAPLVCSGKVLEVQVVNQTSVHVDLGSQP--KENEAEPSTASSVPLQDEQEP 270
              AED + A PL+        Q     ++  +   +P   E E +P  A    L +    
Sbjct: 1348 TTAEDGVPAPPLLDPIVQQFGQFSKDKALEEEEDDRPYDPEEEYDPERAFDTQLVERGRR 1407

Query: 271  PAYDQAPEVTLQADIEVMSTVHISSVYNDVPVTEGVVYIEQLPEQIVIPFTDQVACLKEN 330
               ++APE       EV       ++  +  VT     ++ LP ++         C    
Sbjct: 1408 HEVERAPEAAAAEREEVAYDPEDETILEEAKVT-----VDDLPNRM---------CADVR 1453

Query: 331  EQSKENEQSP---RVSPKSVVEKTTSGMSKKSVESVKLAQLEENAKYSSVYMEAEATAL- 386
              S E    P     +P  V ++       K +E  K  QLEE  +       A   ++ 
Sbjct: 1454 RNSVERPAEPVAGAATPSLVEQQKMLEELNKQIEEQK-RQLEEQEEALRQQRAAVGVSMA 1512

Query: 387  ---LSDTSLKGQP----------EVPAQLLDAEGAIKIGSEKSLHLEVEITSIVSDNTGQ 433
               +SD  +   P          +   Q  D   ++   S+ S H +      ++  TG+
Sbjct: 1513 HFSVSDALMSPPPKSSLPKAELFQQEQQSADKPASLPPASQASNHRDPRQARRLAAETGE 1572

Query: 434  EE----------SGENSVPQEMEGKPVLSGEAAEAVHSGTSVKSS---SGPFPPAPEGLT 480
             E            + ++P+    +  L G+A   V       SS   SG  PPA     
Sbjct: 1573 GEGEPLSRLSARGAQGALPERDASRGGLVGQAPMPVPEEKEPASSPWASGEKPPAGSEQD 1632

Query: 481  APEIEPEGEST 491
              + EP GE T
Sbjct: 1633 GWKAEP-GEGT 1642


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score = 38.9 bits (89), Expect = 0.011
 Identities = 90/395 (22%), Positives = 136/395 (34%), Gaps = 79/395 (20%)

Query: 85    EPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQ---------FPSVYAVPGTEQTE 135
             EP + + E +V T +E+    +E+     E    T +          P V   P  E+ +
Sbjct: 9904  EPEEVAFEEEVVTHVEEYLVEEEEEYIHEEEEFITEEEVVPVIPVKVPEVPRKPVPEEKK 9963

Query: 136   AVGGLSSKPATPKTTTPPSSPPPTAVSPEFAYVPADPAQLAAQMLGKVSSIHS-----DQ 190
              V      P   K   PP+  P     PE   VP    +       KV  +       ++
Sbjct: 9964  PV------PVPKKKEAPPAKVPEVPKKPE-EKVPVLIPKKEKPPPAKVPEVPKKPVPEEK 10016

Query: 191   SDVLMVDVATSMPVVIKEVPSSEAAED-VMVAAPLVCSGKVLEVQVVNQTSVHVDLGSQP 249
               V +     + P  + EVP     E  V V AP        +V  V            P
Sbjct: 10017 VPVPVPKKVEAPPAKVPEVPKKPVPEKKVPVPAPKKVEAPPAKVPEV------------P 10064

Query: 250   KENEAEPSTASSVPLQDEQEPPAYDQAPE-----VTLQADIEVMSTVHISSVYNDVPVTE 304
             K+   E    + VP + E  PP   +  E     V L  + EV+    I      +P  E
Sbjct: 10065 KKLIPEEKKPTPVPKKVEAPPPKVPKKREPVPVPVALPQEEEVLFEEEIVPEEEVLPEEE 10124

Query: 305   GVVYIEQ---------LPEQIVIPFTDQVA------CLKENEQSKENEQSPRVSPKSVVE 349
              V+  E+         LPE+  IP  ++          +E E   E E  P V PK  V 
Sbjct: 10125 EVLPEEEEVLPEEEEVLPEEEEIPPEEEEVPPEEEYVPEEEEFVPEEEVLPEVKPKVPVP 10184

Query: 350   KTTSGMSKKSVESVKLAQLEENAKYSSVYMEAEATALLSDTSLKGQPEVPAQLLDAEGAI 409
                  + KK  E   +   +E A  + V                  PEVP ++   E  I
Sbjct: 10185 APVPEIKKKVTEKKVVIPKKEEAPPAKV------------------PEVPKKV--EEKRI 10224

Query: 410   KIGSEKSLHLEVEITSIVSDNTGQEESGENSVPQE 444
              +  E+ + L VE+T    +   +E   E  +P+E
Sbjct: 10225 ILPKEEEV-LPVEVT----EEPEEEPISEEEIPEE 10254



 Score = 33.9 bits (76), Expect = 0.35
 Identities = 49/222 (22%), Positives = 82/222 (36%), Gaps = 50/222 (22%)

Query: 68   EKWSEGTTPQKKLECLKEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYA 127
            E+W E    ++ ++  KE  + S E KVP ++ +                K    P V  
Sbjct: 9138 EEWEEAYQEREVIQVQKEVYEESHERKVPAKVPEK---------------KAPPPPKVIK 9182

Query: 128  VPGTEQTEAVGGLSSKPATPKTTTPPSSPPPTAVSPEFAYVPADPAQLAAQMLGKVSSIH 187
             P  E+ E       +     T  P  S            VP  P++         + + 
Sbjct: 9183 KPVIEKIEKTSRRMEEEKVQVTKVPEVSK---------KIVPQKPSR---------TPVQ 9224

Query: 188  SDQSDVLMVDVATSMPVVIKEVP--SSEAAEDVMVAAPLVCSGKVLEVQVVNQTSVHVDL 245
             +  +V +  V T   V+ +E    +S   E+V V  P V      + ++V +  +HV +
Sbjct: 9225 EEVIEVKVPAVHTKKMVISEEKMFFASHTEEEVSVTVPEV------QKEIVTEEKIHVAI 9278

Query: 246  GSQ----PKENE----AEPSTASSVPLQDEQEPPAYDQAPEV 279
              +    PK  E      P   + VP+  + EPPA  + PEV
Sbjct: 9279 SKRVEPPPKVPELPEKPAPEEVAPVPIPKKVEPPA-PKVPEV 9319



 Score = 33.5 bits (75), Expect = 0.45
 Identities = 35/165 (21%), Positives = 67/165 (40%), Gaps = 13/165 (7%)

Query: 323   QVACLKENEQSKENEQSPRVSPKSVVEKTTSGMSKKSVESVKLAQLEENAKYSSVYMEAE 382
             Q    K  E ++ N +   ++ + V E  T   S  + E ++  ++E +A    V +   
Sbjct: 25062 QFTVTKLKENTEYNFRICAINSEGVGEPATLPGSVVAQERIEPPEIELDADLRKVVVLRA 25121

Query: 383   ATALLSDTSLKGQPEVPAQLLDAEGAIKIGSEKSLHLEVEITSIVSDNTGQEESGENSVP 442
             +  L    ++KG+PE   +   AEG +       + +    T +V DN  + +SG  ++ 
Sbjct: 25122 SATLRLFVTIKGRPEPEVKWEKAEGILT--DRAQIEVTSSFTMLVIDNVTRFDSGRYNLT 25179

Query: 443   QEMEGKPVLSGEAAEAVHSGTSVKSSSGPFPPAPEGLTAPEIEPE 487
              E       +   ++       V  S    P AP  LT  E++ +
Sbjct: 25180 LE-------NNSGSKTAFVNVRVLDS----PSAPVNLTIREVKKD 25213



 Score = 32.7 bits (73), Expect = 0.77
 Identities = 80/342 (23%), Positives = 123/342 (35%), Gaps = 71/342 (20%)

Query: 65    IKVEKWSEGTTPQKKLECLKEPGKTSVE-SKVPTQMEKSTDTDEDNVTRTEYSDKTTQFP 123
             +KV +  +   P+KK+  +  P K  V  +KVP   + +    E  V         +  P
Sbjct: 10607 VKVPEAPKEVVPEKKVP-VPPPKKPEVPPTKVPEVPKVAVP--EKKVPEAIPPKPESPPP 10663

Query: 124   SVYAVP---GTEQTEAVGGLSSKPATP-KTTTPPSSPPPTAVSPEFAYVPADPAQLAAQM 179
              V+  P     E+  A      +PA P + T PP  P P   +P    V A   +L    
Sbjct: 10664 EVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPA---VVAKKPELP--- 10717

Query: 180   LGKVSSIHSDQSDVLMVDVATSMPVVIKEVPSSEAAEDVMVAAPLVCSGKVLEV--QVVN 237
                                   +P V KEV   +    V+   P     KV EV  +VV 
Sbjct: 10718 -------------------PVKVPEVPKEVVPEKKVPLVVPKKPEAPPAKVPEVPKEVVP 10758

Query: 238   QTSVHVDLGSQPKENEAEPSTASSVPLQDEQEPPAYDQAPEVTLQADIEVMSTVHISSVY 297
             +  V V     PK+ E  P+    VP     + P  ++ P V +    E           
Sbjct: 10759 EKKVAV-----PKKPEVPPAKVPEVP-----KKPVLEEKPAVPVPERAE----------- 10797

Query: 298   NDVPVTEGVVYIEQLPEQIVIPFTDQVACLKENEQSKENEQSPRVSPKSVVEKTTSGMSK 357
                P  E  VY E  PE+I     +++A  +E       E+ P V P +V E+    + +
Sbjct: 10798 --SPPPE--VYEE--PEEIAP--EEEIAPEEEKPVPVAEEEEPEVPPPAVPEEPKKIIPE 10849

Query: 358   KSVESVKLAQLEENAKYSSVYMEAEATALLSDTSLKGQPEVP 399
             K V  +K  +       +    E E   ++    LK +P  P
Sbjct: 10850 KKVPVIKKPE-------APPPKEPEPEKVIEKPKLKPRPPPP 10884


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 38.9 bits (89), Expect = 0.011
 Identities = 32/112 (28%), Positives = 43/112 (38%), Gaps = 16/112 (14%)

Query: 74  TTPQKKLECLKEPGKTSVESKVPTQMEK---STDTDEDNVTRTEYSDKTTQFPSVYAVPG 130
           TTP++     KEP  T+ +   PT  +K   +T  +    T  E +  TT+ PS    P 
Sbjct: 328 TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPS----PT 383

Query: 131 TEQTEAVGGLSSKPATPKTTTP---------PSSPPPTAVSPEFAYVPADPA 173
           T +  A     S P T K   P         P  P PT         P +PA
Sbjct: 384 TPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPA 435



 Score = 37.7 bits (86), Expect = 0.024
 Identities = 25/92 (27%), Positives = 32/92 (34%), Gaps = 2/92 (2%)

Query: 84  KEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTEQTEAVGGLSSK 143
           KEP  T+ +   PT  +K T T  + +  T         P   A    E+          
Sbjct: 472 KEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPA 531

Query: 144 PATPKTTTP--PSSPPPTAVSPEFAYVPADPA 173
           P TPK   P  P  P PT         P +PA
Sbjct: 532 PTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPA 563



 Score = 37.7 bits (86), Expect = 0.024
 Identities = 71/363 (19%), Positives = 118/363 (32%), Gaps = 49/363 (13%)

Query: 74  TTPQKKLECL-KEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTE 132
           TTP++      KE   T+ +   PT +++   T        E +  TT+ P+        
Sbjct: 557 TTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPA 616

Query: 133 QTEAVGGLSSKPATPKTTTP----PSSPPPTAVSPEFAYVPADPAQLAAQML------GK 182
            T   G   + P  P  TTP    P++P  TA +      P  P + A + L      G 
Sbjct: 617 PTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGP 676

Query: 183 VSSIHSDQSDVLMVDVATSMPVVIKEVPSSEAAEDVMVAAPLVCSGKVLEVQVVNQTSVH 242
            S+     +     + A + P         + A       P   S           T++H
Sbjct: 677 TSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIH 736

Query: 243 -------VDLGSQPKENEAE--------PSTASSVPLQDEQEPPAYDQ--------APEV 279
                   +L ++P     E        P+T +    + E    A D+         PE 
Sbjct: 737 KSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPET 796

Query: 280 TLQADIEVMSTVHISSVYNDVPVTEGVVYIEQLPEQIVIPFTDQVACLKENEQSKENEQS 339
           T  A      T   +    +  +T     +     Q   PF  ++  LK          +
Sbjct: 797 TTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPF--KITTLK----------T 844

Query: 340 PRVSPKSVVEK---TTSGMSKKSVESVKLAQLEENAKYSSVYMEAEATALLSDTSLKGQP 396
             ++PK    K   TT+ +  K  E+ K      N+K ++   +    A    TS K   
Sbjct: 845 TTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPK 904

Query: 397 EVP 399
            +P
Sbjct: 905 TMP 907



 Score = 36.2 bits (82), Expect = 0.070
 Identities = 32/107 (29%), Positives = 43/107 (40%), Gaps = 8/107 (7%)

Query: 74  TTPQKKLECL-KEPGKTSVESKVPTQMEKS-TDTDEDNVTRTEYSDKTTQFPSVYA---- 127
           TTP++      KEP  T+++S   T  E + T T     T  E +  TT+ P+       
Sbjct: 219 TTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEP 278

Query: 128 VPGTEQTEAVGGLSSKPATPKTTTP--PSSPPPTAVSPEFAYVPADP 172
            P T +  A     S P TPK   P  P  P PT         P +P
Sbjct: 279 APTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP 325



 Score = 35.8 bits (81), Expect = 0.091
 Identities = 30/109 (27%), Positives = 41/109 (37%), Gaps = 9/109 (8%)

Query: 74  TTPQKKLECL-KEPGKTSVESKVPTQMEKS-TDTDEDNVTRTEYSDKTTQFPSVYAVPGT 131
           TTP++      KEP  T+ +   PT  + + T T E   T T+ +  T + PS       
Sbjct: 367 TTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEP 426

Query: 132 EQTEAVGGLSSKPATPKTTTP-------PSSPPPTAVSPEFAYVPADPA 173
             T       + P  P  TTP       P  P PT         P +PA
Sbjct: 427 APTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPA 475



 Score = 35.0 bits (79), Expect = 0.16
 Identities = 27/103 (26%), Positives = 36/103 (34%), Gaps = 3/103 (2%)

Query: 74  TTPQKKLECL-KEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTE 132
           TTP++      KEP  T+ +   PT  ++   T       T     T   P   A    E
Sbjct: 445 TTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPE 504

Query: 133 QTEAVGGLSSKPATPKTTTP--PSSPPPTAVSPEFAYVPADPA 173
           +          P TP+  TP  P  P PT         P +PA
Sbjct: 505 KPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPA 547



 Score = 33.1 bits (74), Expect = 0.59
 Identities = 61/323 (18%), Positives = 104/323 (32%), Gaps = 49/323 (15%)

Query: 84  KEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTEQTEAVGGLSSK 143
           KEP  T+ +   PT  +++  T       T   +     P   A      T      S+ 
Sbjct: 552 KEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTT 611

Query: 144 PATPKTTTPPSSPPPTAVSPEFAYVPADPAQLAAQMLGKVSSIHSDQSDVLMVDVATSMP 203
              P  TTP  + P T   P     P +PA    +                      + P
Sbjct: 612 CDKPAPTTPKGTAPTTPKEPA-PTTPKEPAPTTPK---------------------GTAP 649

Query: 204 VVIKE-VPSSEAAEDVMVAAPLVCSGKVLEVQVVNQTSVHVDLGSQPKENEAEPSTASS- 261
             +KE  P++         AP    G          TS   D  +     E  P+T    
Sbjct: 650 TTLKEPAPTTPKKPAPKELAPTTTKG---------PTSTTSDKPAPTTPKETAPTTPKEP 700

Query: 262 VPLQDEQEPPAYDQAP-----EVTLQADIEVMSTVHISSVYN--DVPVTEGVVYIEQLPE 314
            P   ++  P   + P     EV+     +  +T+H S   +  ++        +E  P+
Sbjct: 701 APTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPK 760

Query: 315 QIVIPFTDQVACLK----ENEQSKENEQSPRVSPKSVVEKTTSGMSKKSVESVKLAQLEE 370
           +  +P T   A  K       + K  E+  R +P     +TT+   K + E+    +   
Sbjct: 761 EPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTP-----ETTTAAPKMTKETATTTEKTT 815

Query: 371 NAKYSSVYMEAEATALLSDTSLK 393
            +K ++   +  +T     T  K
Sbjct: 816 ESKITATTTQVTSTTTQDTTPFK 838



 Score = 32.3 bits (72), Expect = 1.0
 Identities = 30/105 (28%), Positives = 41/105 (39%), Gaps = 9/105 (8%)

Query: 74  TTPQKKLECL-KEPGKTSVESKVPTQMEKSTDTDEDNVTRT--EYSDKTTQFPSVYAVPG 130
           TTP++      KEP  T+ +S   T  E +  T +     T  E +  T + P+    P 
Sbjct: 273 TTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPT----PT 328

Query: 131 TEQTEAVGGLSSKPATPKTTTP--PSSPPPTAVSPEFAYVPADPA 173
           T +  A       P TPK   P  P  P PT         P +PA
Sbjct: 329 TPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPA 373



 Score = 32.0 bits (71), Expect = 1.3
 Identities = 22/91 (24%), Positives = 32/91 (35%)

Query: 74  TTPQKKLECLKEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTEQ 133
           TT +      KEP  T+ +   PT  ++   T       T   +     P   A   T++
Sbjct: 406 TTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKK 465

Query: 134 TEAVGGLSSKPATPKTTTPPSSPPPTAVSPE 164
                     P TPK T P +    T  +PE
Sbjct: 466 PAPTTPKEPAPTTPKETAPTTPKKLTPTTPE 496



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 26/93 (27%), Positives = 39/93 (41%), Gaps = 13/93 (13%)

Query: 74  TTPQKKLECLKEPGKTSVESKVPTQMEKS--TDTDEDNVTRTEYSDKTTQFPSVYAVPGT 131
           TT +      KEP  T+ +   PT  ++   T T E   T T+ +  T + P+    P T
Sbjct: 250 TTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPA----PTT 305

Query: 132 EQTEAVGGLSSKPATPKTTTPPSSPPPTAVSPE 164
            +  A       P TPK   P +   PT  +P+
Sbjct: 306 PKKPA-------PTTPKEPAPTTPKEPTPTTPK 331



 Score = 29.6 bits (65), Expect = 6.6
 Identities = 30/141 (21%), Positives = 54/141 (38%), Gaps = 5/141 (3%)

Query: 27  KTNPSNINQFAAAYFQELTMYRGNTTMDIKDLVKQFHQIK-VEKWS-EGTTPQKKLECLK 84
           K     +N+      +E T     T+ D K+      + + +EK S +   P  K+    
Sbjct: 138 KETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKP 197

Query: 85  EP-GKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTEQTEAVGGLSSK 143
            P  +T+ +    T  ++ T T       T   + T    ++ + P T +  A     S 
Sbjct: 198 TPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPT--TIKSAPTTPKEPAPTTTKSA 255

Query: 144 PATPKTTTPPSSPPPTAVSPE 164
           P TPK   P ++  P   +P+
Sbjct: 256 PTTPKEPAPTTTKEPAPTTPK 276



 Score = 29.3 bits (64), Expect = 8.6
 Identities = 32/136 (23%), Positives = 47/136 (34%), Gaps = 17/136 (12%)

Query: 51  TTMDIKDLVKQFHQIKVEKWSEGTTPQKKLECLKEPGKTSVESKVPTQ--MEKSTDTDED 108
           TT++ K+      Q   +   E TT  K+ + ++   KTS +   PT   + K T   E 
Sbjct: 148 TTVETKETTTTNKQTSTDG-KEKTTSAKETQSIE---KTSAKDLAPTSKVLAKPTPKAET 203

Query: 109 NVTRTEYSDKTTQFPSVYAVPG--TEQTEAVGGLSSKPATPKTTTP---------PSSPP 157
                  +      P+    P   T +      + S P TPK   P         P  P 
Sbjct: 204 TTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPA 263

Query: 158 PTAVSPEFAYVPADPA 173
           PT         P +PA
Sbjct: 264 PTTTKEPAPTTPKEPA 279


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 38.9 bits (89), Expect = 0.011
 Identities = 32/112 (28%), Positives = 43/112 (38%), Gaps = 16/112 (14%)

Query: 74  TTPQKKLECLKEPGKTSVESKVPTQMEK---STDTDEDNVTRTEYSDKTTQFPSVYAVPG 130
           TTP++     KEP  T+ +   PT  +K   +T  +    T  E +  TT+ PS    P 
Sbjct: 369 TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPS----PT 424

Query: 131 TEQTEAVGGLSSKPATPKTTTP---------PSSPPPTAVSPEFAYVPADPA 173
           T +  A     S P T K   P         P  P PT         P +PA
Sbjct: 425 TPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPA 476



 Score = 37.7 bits (86), Expect = 0.024
 Identities = 25/92 (27%), Positives = 32/92 (34%), Gaps = 2/92 (2%)

Query: 84  KEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTEQTEAVGGLSSK 143
           KEP  T+ +   PT  +K T T  + +  T         P   A    E+          
Sbjct: 513 KEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPA 572

Query: 144 PATPKTTTP--PSSPPPTAVSPEFAYVPADPA 173
           P TPK   P  P  P PT         P +PA
Sbjct: 573 PTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPA 604



 Score = 37.7 bits (86), Expect = 0.024
 Identities = 71/363 (19%), Positives = 118/363 (32%), Gaps = 49/363 (13%)

Query: 74  TTPQKKLECL-KEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTE 132
           TTP++      KE   T+ +   PT +++   T        E +  TT+ P+        
Sbjct: 598 TTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPA 657

Query: 133 QTEAVGGLSSKPATPKTTTP----PSSPPPTAVSPEFAYVPADPAQLAAQML------GK 182
            T   G   + P  P  TTP    P++P  TA +      P  P + A + L      G 
Sbjct: 658 PTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGP 717

Query: 183 VSSIHSDQSDVLMVDVATSMPVVIKEVPSSEAAEDVMVAAPLVCSGKVLEVQVVNQTSVH 242
            S+     +     + A + P         + A       P   S           T++H
Sbjct: 718 TSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIH 777

Query: 243 -------VDLGSQPKENEAE--------PSTASSVPLQDEQEPPAYDQ--------APEV 279
                   +L ++P     E        P+T +    + E    A D+         PE 
Sbjct: 778 KSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPET 837

Query: 280 TLQADIEVMSTVHISSVYNDVPVTEGVVYIEQLPEQIVIPFTDQVACLKENEQSKENEQS 339
           T  A      T   +    +  +T     +     Q   PF  ++  LK          +
Sbjct: 838 TTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPF--KITTLK----------T 885

Query: 340 PRVSPKSVVEK---TTSGMSKKSVESVKLAQLEENAKYSSVYMEAEATALLSDTSLKGQP 396
             ++PK    K   TT+ +  K  E+ K      N+K ++   +    A    TS K   
Sbjct: 886 TTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPK 945

Query: 397 EVP 399
            +P
Sbjct: 946 TMP 948



 Score = 36.2 bits (82), Expect = 0.070
 Identities = 32/107 (29%), Positives = 43/107 (40%), Gaps = 8/107 (7%)

Query: 74  TTPQKKLECL-KEPGKTSVESKVPTQMEKS-TDTDEDNVTRTEYSDKTTQFPSVYA---- 127
           TTP++      KEP  T+++S   T  E + T T     T  E +  TT+ P+       
Sbjct: 260 TTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEP 319

Query: 128 VPGTEQTEAVGGLSSKPATPKTTTP--PSSPPPTAVSPEFAYVPADP 172
            P T +  A     S P TPK   P  P  P PT         P +P
Sbjct: 320 APTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP 366



 Score = 35.8 bits (81), Expect = 0.091
 Identities = 30/109 (27%), Positives = 41/109 (37%), Gaps = 9/109 (8%)

Query: 74  TTPQKKLECL-KEPGKTSVESKVPTQMEKS-TDTDEDNVTRTEYSDKTTQFPSVYAVPGT 131
           TTP++      KEP  T+ +   PT  + + T T E   T T+ +  T + PS       
Sbjct: 408 TTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEP 467

Query: 132 EQTEAVGGLSSKPATPKTTTP-------PSSPPPTAVSPEFAYVPADPA 173
             T       + P  P  TTP       P  P PT         P +PA
Sbjct: 468 APTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPA 516



 Score = 35.0 bits (79), Expect = 0.16
 Identities = 27/103 (26%), Positives = 36/103 (34%), Gaps = 3/103 (2%)

Query: 74  TTPQKKLECL-KEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTE 132
           TTP++      KEP  T+ +   PT  ++   T       T     T   P   A    E
Sbjct: 486 TTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPE 545

Query: 133 QTEAVGGLSSKPATPKTTTP--PSSPPPTAVSPEFAYVPADPA 173
           +          P TP+  TP  P  P PT         P +PA
Sbjct: 546 KPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPA 588



 Score = 33.1 bits (74), Expect = 0.59
 Identities = 61/323 (18%), Positives = 104/323 (32%), Gaps = 49/323 (15%)

Query: 84  KEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTEQTEAVGGLSSK 143
           KEP  T+ +   PT  +++  T       T   +     P   A      T      S+ 
Sbjct: 593 KEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTT 652

Query: 144 PATPKTTTPPSSPPPTAVSPEFAYVPADPAQLAAQMLGKVSSIHSDQSDVLMVDVATSMP 203
              P  TTP  + P T   P     P +PA    +                      + P
Sbjct: 653 CDKPAPTTPKGTAPTTPKEPA-PTTPKEPAPTTPK---------------------GTAP 690

Query: 204 VVIKE-VPSSEAAEDVMVAAPLVCSGKVLEVQVVNQTSVHVDLGSQPKENEAEPSTASS- 261
             +KE  P++         AP    G          TS   D  +     E  P+T    
Sbjct: 691 TTLKEPAPTTPKKPAPKELAPTTTKG---------PTSTTSDKPAPTTPKETAPTTPKEP 741

Query: 262 VPLQDEQEPPAYDQAP-----EVTLQADIEVMSTVHISSVYN--DVPVTEGVVYIEQLPE 314
            P   ++  P   + P     EV+     +  +T+H S   +  ++        +E  P+
Sbjct: 742 APTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPK 801

Query: 315 QIVIPFTDQVACLK----ENEQSKENEQSPRVSPKSVVEKTTSGMSKKSVESVKLAQLEE 370
           +  +P T   A  K       + K  E+  R +P     +TT+   K + E+    +   
Sbjct: 802 EPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTP-----ETTTAAPKMTKETATTTEKTT 856

Query: 371 NAKYSSVYMEAEATALLSDTSLK 393
            +K ++   +  +T     T  K
Sbjct: 857 ESKITATTTQVTSTTTQDTTPFK 879



 Score = 32.3 bits (72), Expect = 1.0
 Identities = 30/105 (28%), Positives = 41/105 (39%), Gaps = 9/105 (8%)

Query: 74  TTPQKKLECL-KEPGKTSVESKVPTQMEKSTDTDEDNVTRT--EYSDKTTQFPSVYAVPG 130
           TTP++      KEP  T+ +S   T  E +  T +     T  E +  T + P+    P 
Sbjct: 314 TTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPT----PT 369

Query: 131 TEQTEAVGGLSSKPATPKTTTP--PSSPPPTAVSPEFAYVPADPA 173
           T +  A       P TPK   P  P  P PT         P +PA
Sbjct: 370 TPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPA 414



 Score = 32.0 bits (71), Expect = 1.3
 Identities = 22/91 (24%), Positives = 32/91 (35%)

Query: 74  TTPQKKLECLKEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTEQ 133
           TT +      KEP  T+ +   PT  ++   T       T   +     P   A   T++
Sbjct: 447 TTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKK 506

Query: 134 TEAVGGLSSKPATPKTTTPPSSPPPTAVSPE 164
                     P TPK T P +    T  +PE
Sbjct: 507 PAPTTPKEPAPTTPKETAPTTPKKLTPTTPE 537



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 26/93 (27%), Positives = 39/93 (41%), Gaps = 13/93 (13%)

Query: 74  TTPQKKLECLKEPGKTSVESKVPTQMEKS--TDTDEDNVTRTEYSDKTTQFPSVYAVPGT 131
           TT +      KEP  T+ +   PT  ++   T T E   T T+ +  T + P+    P T
Sbjct: 291 TTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPA----PTT 346

Query: 132 EQTEAVGGLSSKPATPKTTTPPSSPPPTAVSPE 164
            +  A       P TPK   P +   PT  +P+
Sbjct: 347 PKKPA-------PTTPKEPAPTTPKEPTPTTPK 372



 Score = 29.6 bits (65), Expect = 6.6
 Identities = 30/141 (21%), Positives = 54/141 (38%), Gaps = 5/141 (3%)

Query: 27  KTNPSNINQFAAAYFQELTMYRGNTTMDIKDLVKQFHQIK-VEKWS-EGTTPQKKLECLK 84
           K     +N+      +E T     T+ D K+      + + +EK S +   P  K+    
Sbjct: 179 KETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKP 238

Query: 85  EP-GKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTEQTEAVGGLSSK 143
            P  +T+ +    T  ++ T T       T   + T    ++ + P T +  A     S 
Sbjct: 239 TPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPT--TIKSAPTTPKEPAPTTTKSA 296

Query: 144 PATPKTTTPPSSPPPTAVSPE 164
           P TPK   P ++  P   +P+
Sbjct: 297 PTTPKEPAPTTTKEPAPTTPK 317



 Score = 29.3 bits (64), Expect = 8.6
 Identities = 32/136 (23%), Positives = 47/136 (34%), Gaps = 17/136 (12%)

Query: 51  TTMDIKDLVKQFHQIKVEKWSEGTTPQKKLECLKEPGKTSVESKVPTQ--MEKSTDTDED 108
           TT++ K+      Q   +   E TT  K+ + ++   KTS +   PT   + K T   E 
Sbjct: 189 TTVETKETTTTNKQTSTDG-KEKTTSAKETQSIE---KTSAKDLAPTSKVLAKPTPKAET 244

Query: 109 NVTRTEYSDKTTQFPSVYAVPG--TEQTEAVGGLSSKPATPKTTTP---------PSSPP 157
                  +      P+    P   T +      + S P TPK   P         P  P 
Sbjct: 245 TTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPA 304

Query: 158 PTAVSPEFAYVPADPA 173
           PT         P +PA
Sbjct: 305 PTTTKEPAPTTPKEPA 320


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 38.9 bits (89), Expect = 0.011
 Identities = 32/112 (28%), Positives = 43/112 (38%), Gaps = 16/112 (14%)

Query: 74  TTPQKKLECLKEPGKTSVESKVPTQMEK---STDTDEDNVTRTEYSDKTTQFPSVYAVPG 130
           TTP++     KEP  T+ +   PT  +K   +T  +    T  E +  TT+ PS    P 
Sbjct: 421 TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPS----PT 476

Query: 131 TEQTEAVGGLSSKPATPKTTTP---------PSSPPPTAVSPEFAYVPADPA 173
           T +  A     S P T K   P         P  P PT         P +PA
Sbjct: 477 TPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPA 528



 Score = 37.7 bits (86), Expect = 0.024
 Identities = 25/92 (27%), Positives = 32/92 (34%), Gaps = 2/92 (2%)

Query: 84  KEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTEQTEAVGGLSSK 143
           KEP  T+ +   PT  +K T T  + +  T         P   A    E+          
Sbjct: 565 KEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPA 624

Query: 144 PATPKTTTP--PSSPPPTAVSPEFAYVPADPA 173
           P TPK   P  P  P PT         P +PA
Sbjct: 625 PTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPA 656



 Score = 37.7 bits (86), Expect = 0.024
 Identities = 71/363 (19%), Positives = 118/363 (32%), Gaps = 49/363 (13%)

Query: 74   TTPQKKLECL-KEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTE 132
            TTP++      KE   T+ +   PT +++   T        E +  TT+ P+        
Sbjct: 650  TTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPA 709

Query: 133  QTEAVGGLSSKPATPKTTTP----PSSPPPTAVSPEFAYVPADPAQLAAQML------GK 182
             T   G   + P  P  TTP    P++P  TA +      P  P + A + L      G 
Sbjct: 710  PTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGP 769

Query: 183  VSSIHSDQSDVLMVDVATSMPVVIKEVPSSEAAEDVMVAAPLVCSGKVLEVQVVNQTSVH 242
             S+     +     + A + P         + A       P   S           T++H
Sbjct: 770  TSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIH 829

Query: 243  -------VDLGSQPKENEAE--------PSTASSVPLQDEQEPPAYDQ--------APEV 279
                    +L ++P     E        P+T +    + E    A D+         PE 
Sbjct: 830  KSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPET 889

Query: 280  TLQADIEVMSTVHISSVYNDVPVTEGVVYIEQLPEQIVIPFTDQVACLKENEQSKENEQS 339
            T  A      T   +    +  +T     +     Q   PF  ++  LK          +
Sbjct: 890  TTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPF--KITTLK----------T 937

Query: 340  PRVSPKSVVEK---TTSGMSKKSVESVKLAQLEENAKYSSVYMEAEATALLSDTSLKGQP 396
              ++PK    K   TT+ +  K  E+ K      N+K ++   +    A    TS K   
Sbjct: 938  TTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPK 997

Query: 397  EVP 399
             +P
Sbjct: 998  TMP 1000



 Score = 36.2 bits (82), Expect = 0.070
 Identities = 32/107 (29%), Positives = 43/107 (40%), Gaps = 8/107 (7%)

Query: 74  TTPQKKLECL-KEPGKTSVESKVPTQMEKS-TDTDEDNVTRTEYSDKTTQFPSVYA---- 127
           TTP++      KEP  T+++S   T  E + T T     T  E +  TT+ P+       
Sbjct: 312 TTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEP 371

Query: 128 VPGTEQTEAVGGLSSKPATPKTTTP--PSSPPPTAVSPEFAYVPADP 172
            P T +  A     S P TPK   P  P  P PT         P +P
Sbjct: 372 APTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP 418



 Score = 35.8 bits (81), Expect = 0.091
 Identities = 30/109 (27%), Positives = 41/109 (37%), Gaps = 9/109 (8%)

Query: 74  TTPQKKLECL-KEPGKTSVESKVPTQMEKS-TDTDEDNVTRTEYSDKTTQFPSVYAVPGT 131
           TTP++      KEP  T+ +   PT  + + T T E   T T+ +  T + PS       
Sbjct: 460 TTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEP 519

Query: 132 EQTEAVGGLSSKPATPKTTTP-------PSSPPPTAVSPEFAYVPADPA 173
             T       + P  P  TTP       P  P PT         P +PA
Sbjct: 520 APTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPA 568



 Score = 35.0 bits (79), Expect = 0.16
 Identities = 27/103 (26%), Positives = 36/103 (34%), Gaps = 3/103 (2%)

Query: 74  TTPQKKLECL-KEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTE 132
           TTP++      KEP  T+ +   PT  ++   T       T     T   P   A    E
Sbjct: 538 TTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPE 597

Query: 133 QTEAVGGLSSKPATPKTTTP--PSSPPPTAVSPEFAYVPADPA 173
           +          P TP+  TP  P  P PT         P +PA
Sbjct: 598 KPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPA 640



 Score = 33.1 bits (74), Expect = 0.59
 Identities = 61/323 (18%), Positives = 104/323 (32%), Gaps = 49/323 (15%)

Query: 84  KEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTEQTEAVGGLSSK 143
           KEP  T+ +   PT  +++  T       T   +     P   A      T      S+ 
Sbjct: 645 KEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTT 704

Query: 144 PATPKTTTPPSSPPPTAVSPEFAYVPADPAQLAAQMLGKVSSIHSDQSDVLMVDVATSMP 203
              P  TTP  + P T   P     P +PA    +                      + P
Sbjct: 705 CDKPAPTTPKGTAPTTPKEPA-PTTPKEPAPTTPK---------------------GTAP 742

Query: 204 VVIKE-VPSSEAAEDVMVAAPLVCSGKVLEVQVVNQTSVHVDLGSQPKENEAEPSTASS- 261
             +KE  P++         AP    G          TS   D  +     E  P+T    
Sbjct: 743 TTLKEPAPTTPKKPAPKELAPTTTKG---------PTSTTSDKPAPTTPKETAPTTPKEP 793

Query: 262 VPLQDEQEPPAYDQAP-----EVTLQADIEVMSTVHISSVYN--DVPVTEGVVYIEQLPE 314
            P   ++  P   + P     EV+     +  +T+H S   +  ++        +E  P+
Sbjct: 794 APTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPK 853

Query: 315 QIVIPFTDQVACLK----ENEQSKENEQSPRVSPKSVVEKTTSGMSKKSVESVKLAQLEE 370
           +  +P T   A  K       + K  E+  R +P     +TT+   K + E+    +   
Sbjct: 854 EPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTP-----ETTTAAPKMTKETATTTEKTT 908

Query: 371 NAKYSSVYMEAEATALLSDTSLK 393
            +K ++   +  +T     T  K
Sbjct: 909 ESKITATTTQVTSTTTQDTTPFK 931



 Score = 32.3 bits (72), Expect = 1.0
 Identities = 30/105 (28%), Positives = 41/105 (39%), Gaps = 9/105 (8%)

Query: 74  TTPQKKLECL-KEPGKTSVESKVPTQMEKSTDTDEDNVTRT--EYSDKTTQFPSVYAVPG 130
           TTP++      KEP  T+ +S   T  E +  T +     T  E +  T + P+    P 
Sbjct: 366 TTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPT----PT 421

Query: 131 TEQTEAVGGLSSKPATPKTTTP--PSSPPPTAVSPEFAYVPADPA 173
           T +  A       P TPK   P  P  P PT         P +PA
Sbjct: 422 TPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPA 466



 Score = 32.0 bits (71), Expect = 1.3
 Identities = 22/91 (24%), Positives = 32/91 (35%)

Query: 74  TTPQKKLECLKEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTEQ 133
           TT +      KEP  T+ +   PT  ++   T       T   +     P   A   T++
Sbjct: 499 TTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKK 558

Query: 134 TEAVGGLSSKPATPKTTTPPSSPPPTAVSPE 164
                     P TPK T P +    T  +PE
Sbjct: 559 PAPTTPKEPAPTTPKETAPTTPKKLTPTTPE 589



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 26/93 (27%), Positives = 39/93 (41%), Gaps = 13/93 (13%)

Query: 74  TTPQKKLECLKEPGKTSVESKVPTQMEKS--TDTDEDNVTRTEYSDKTTQFPSVYAVPGT 131
           TT +      KEP  T+ +   PT  ++   T T E   T T+ +  T + P+    P T
Sbjct: 343 TTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPA----PTT 398

Query: 132 EQTEAVGGLSSKPATPKTTTPPSSPPPTAVSPE 164
            +  A       P TPK   P +   PT  +P+
Sbjct: 399 PKKPA-------PTTPKEPAPTTPKEPTPTTPK 424



 Score = 29.6 bits (65), Expect = 6.6
 Identities = 30/141 (21%), Positives = 54/141 (38%), Gaps = 5/141 (3%)

Query: 27  KTNPSNINQFAAAYFQELTMYRGNTTMDIKDLVKQFHQIK-VEKWS-EGTTPQKKLECLK 84
           K     +N+      +E T     T+ D K+      + + +EK S +   P  K+    
Sbjct: 231 KETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKP 290

Query: 85  EP-GKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTEQTEAVGGLSSK 143
            P  +T+ +    T  ++ T T       T   + T    ++ + P T +  A     S 
Sbjct: 291 TPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPT--TIKSAPTTPKEPAPTTTKSA 348

Query: 144 PATPKTTTPPSSPPPTAVSPE 164
           P TPK   P ++  P   +P+
Sbjct: 349 PTTPKEPAPTTTKEPAPTTPK 369



 Score = 29.3 bits (64), Expect = 8.6
 Identities = 32/136 (23%), Positives = 47/136 (34%), Gaps = 17/136 (12%)

Query: 51  TTMDIKDLVKQFHQIKVEKWSEGTTPQKKLECLKEPGKTSVESKVPTQ--MEKSTDTDED 108
           TT++ K+      Q   +   E TT  K+ + ++   KTS +   PT   + K T   E 
Sbjct: 241 TTVETKETTTTNKQTSTDG-KEKTTSAKETQSIE---KTSAKDLAPTSKVLAKPTPKAET 296

Query: 109 NVTRTEYSDKTTQFPSVYAVPG--TEQTEAVGGLSSKPATPKTTTP---------PSSPP 157
                  +      P+    P   T +      + S P TPK   P         P  P 
Sbjct: 297 TTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPA 356

Query: 158 PTAVSPEFAYVPADPA 173
           PT         P +PA
Sbjct: 357 PTTTKEPAPTTPKEPA 372


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 38.9 bits (89), Expect = 0.011
 Identities = 32/112 (28%), Positives = 43/112 (38%), Gaps = 16/112 (14%)

Query: 74  TTPQKKLECLKEPGKTSVESKVPTQMEK---STDTDEDNVTRTEYSDKTTQFPSVYAVPG 130
           TTP++     KEP  T+ +   PT  +K   +T  +    T  E +  TT+ PS    P 
Sbjct: 462 TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPS----PT 517

Query: 131 TEQTEAVGGLSSKPATPKTTTP---------PSSPPPTAVSPEFAYVPADPA 173
           T +  A     S P T K   P         P  P PT         P +PA
Sbjct: 518 TPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPA 569



 Score = 37.7 bits (86), Expect = 0.024
 Identities = 25/92 (27%), Positives = 32/92 (34%), Gaps = 2/92 (2%)

Query: 84  KEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTEQTEAVGGLSSK 143
           KEP  T+ +   PT  +K T T  + +  T         P   A    E+          
Sbjct: 606 KEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPA 665

Query: 144 PATPKTTTP--PSSPPPTAVSPEFAYVPADPA 173
           P TPK   P  P  P PT         P +PA
Sbjct: 666 PTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPA 697



 Score = 37.7 bits (86), Expect = 0.024
 Identities = 71/363 (19%), Positives = 118/363 (32%), Gaps = 49/363 (13%)

Query: 74   TTPQKKLECL-KEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTE 132
            TTP++      KE   T+ +   PT +++   T        E +  TT+ P+        
Sbjct: 691  TTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPA 750

Query: 133  QTEAVGGLSSKPATPKTTTP----PSSPPPTAVSPEFAYVPADPAQLAAQML------GK 182
             T   G   + P  P  TTP    P++P  TA +      P  P + A + L      G 
Sbjct: 751  PTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGP 810

Query: 183  VSSIHSDQSDVLMVDVATSMPVVIKEVPSSEAAEDVMVAAPLVCSGKVLEVQVVNQTSVH 242
             S+     +     + A + P         + A       P   S           T++H
Sbjct: 811  TSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIH 870

Query: 243  -------VDLGSQPKENEAE--------PSTASSVPLQDEQEPPAYDQ--------APEV 279
                    +L ++P     E        P+T +    + E    A D+         PE 
Sbjct: 871  KSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPET 930

Query: 280  TLQADIEVMSTVHISSVYNDVPVTEGVVYIEQLPEQIVIPFTDQVACLKENEQSKENEQS 339
            T  A      T   +    +  +T     +     Q   PF  ++  LK          +
Sbjct: 931  TTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPF--KITTLK----------T 978

Query: 340  PRVSPKSVVEK---TTSGMSKKSVESVKLAQLEENAKYSSVYMEAEATALLSDTSLKGQP 396
              ++PK    K   TT+ +  K  E+ K      N+K ++   +    A    TS K   
Sbjct: 979  TTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPK 1038

Query: 397  EVP 399
             +P
Sbjct: 1039 TMP 1041



 Score = 36.2 bits (82), Expect = 0.070
 Identities = 32/107 (29%), Positives = 43/107 (40%), Gaps = 8/107 (7%)

Query: 74  TTPQKKLECL-KEPGKTSVESKVPTQMEKS-TDTDEDNVTRTEYSDKTTQFPSVYA---- 127
           TTP++      KEP  T+++S   T  E + T T     T  E +  TT+ P+       
Sbjct: 353 TTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEP 412

Query: 128 VPGTEQTEAVGGLSSKPATPKTTTP--PSSPPPTAVSPEFAYVPADP 172
            P T +  A     S P TPK   P  P  P PT         P +P
Sbjct: 413 APTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP 459



 Score = 35.8 bits (81), Expect = 0.091
 Identities = 30/109 (27%), Positives = 41/109 (37%), Gaps = 9/109 (8%)

Query: 74  TTPQKKLECL-KEPGKTSVESKVPTQMEKS-TDTDEDNVTRTEYSDKTTQFPSVYAVPGT 131
           TTP++      KEP  T+ +   PT  + + T T E   T T+ +  T + PS       
Sbjct: 501 TTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEP 560

Query: 132 EQTEAVGGLSSKPATPKTTTP-------PSSPPPTAVSPEFAYVPADPA 173
             T       + P  P  TTP       P  P PT         P +PA
Sbjct: 561 APTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPA 609



 Score = 35.0 bits (79), Expect = 0.16
 Identities = 27/103 (26%), Positives = 36/103 (34%), Gaps = 3/103 (2%)

Query: 74  TTPQKKLECL-KEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTE 132
           TTP++      KEP  T+ +   PT  ++   T       T     T   P   A    E
Sbjct: 579 TTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPE 638

Query: 133 QTEAVGGLSSKPATPKTTTP--PSSPPPTAVSPEFAYVPADPA 173
           +          P TP+  TP  P  P PT         P +PA
Sbjct: 639 KPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPA 681



 Score = 33.1 bits (74), Expect = 0.59
 Identities = 61/323 (18%), Positives = 104/323 (32%), Gaps = 49/323 (15%)

Query: 84  KEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTEQTEAVGGLSSK 143
           KEP  T+ +   PT  +++  T       T   +     P   A      T      S+ 
Sbjct: 686 KEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTT 745

Query: 144 PATPKTTTPPSSPPPTAVSPEFAYVPADPAQLAAQMLGKVSSIHSDQSDVLMVDVATSMP 203
              P  TTP  + P T   P     P +PA    +                      + P
Sbjct: 746 CDKPAPTTPKGTAPTTPKEPA-PTTPKEPAPTTPK---------------------GTAP 783

Query: 204 VVIKE-VPSSEAAEDVMVAAPLVCSGKVLEVQVVNQTSVHVDLGSQPKENEAEPSTASS- 261
             +KE  P++         AP    G          TS   D  +     E  P+T    
Sbjct: 784 TTLKEPAPTTPKKPAPKELAPTTTKG---------PTSTTSDKPAPTTPKETAPTTPKEP 834

Query: 262 VPLQDEQEPPAYDQAP-----EVTLQADIEVMSTVHISSVYN--DVPVTEGVVYIEQLPE 314
            P   ++  P   + P     EV+     +  +T+H S   +  ++        +E  P+
Sbjct: 835 APTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPK 894

Query: 315 QIVIPFTDQVACLK----ENEQSKENEQSPRVSPKSVVEKTTSGMSKKSVESVKLAQLEE 370
           +  +P T   A  K       + K  E+  R +P     +TT+   K + E+    +   
Sbjct: 895 EPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTP-----ETTTAAPKMTKETATTTEKTT 949

Query: 371 NAKYSSVYMEAEATALLSDTSLK 393
            +K ++   +  +T     T  K
Sbjct: 950 ESKITATTTQVTSTTTQDTTPFK 972



 Score = 32.3 bits (72), Expect = 1.0
 Identities = 30/105 (28%), Positives = 41/105 (39%), Gaps = 9/105 (8%)

Query: 74  TTPQKKLECL-KEPGKTSVESKVPTQMEKSTDTDEDNVTRT--EYSDKTTQFPSVYAVPG 130
           TTP++      KEP  T+ +S   T  E +  T +     T  E +  T + P+    P 
Sbjct: 407 TTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPT----PT 462

Query: 131 TEQTEAVGGLSSKPATPKTTTP--PSSPPPTAVSPEFAYVPADPA 173
           T +  A       P TPK   P  P  P PT         P +PA
Sbjct: 463 TPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPA 507



 Score = 32.0 bits (71), Expect = 1.3
 Identities = 22/91 (24%), Positives = 32/91 (35%)

Query: 74  TTPQKKLECLKEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTEQ 133
           TT +      KEP  T+ +   PT  ++   T       T   +     P   A   T++
Sbjct: 540 TTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKK 599

Query: 134 TEAVGGLSSKPATPKTTTPPSSPPPTAVSPE 164
                     P TPK T P +    T  +PE
Sbjct: 600 PAPTTPKEPAPTTPKETAPTTPKKLTPTTPE 630



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 26/93 (27%), Positives = 39/93 (41%), Gaps = 13/93 (13%)

Query: 74  TTPQKKLECLKEPGKTSVESKVPTQMEKS--TDTDEDNVTRTEYSDKTTQFPSVYAVPGT 131
           TT +      KEP  T+ +   PT  ++   T T E   T T+ +  T + P+    P T
Sbjct: 384 TTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPA----PTT 439

Query: 132 EQTEAVGGLSSKPATPKTTTPPSSPPPTAVSPE 164
            +  A       P TPK   P +   PT  +P+
Sbjct: 440 PKKPA-------PTTPKEPAPTTPKEPTPTTPK 465



 Score = 29.6 bits (65), Expect = 6.6
 Identities = 30/141 (21%), Positives = 54/141 (38%), Gaps = 5/141 (3%)

Query: 27  KTNPSNINQFAAAYFQELTMYRGNTTMDIKDLVKQFHQIK-VEKWS-EGTTPQKKLECLK 84
           K     +N+      +E T     T+ D K+      + + +EK S +   P  K+    
Sbjct: 272 KETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKP 331

Query: 85  EP-GKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTEQTEAVGGLSSK 143
            P  +T+ +    T  ++ T T       T   + T    ++ + P T +  A     S 
Sbjct: 332 TPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPT--TIKSAPTTPKEPAPTTTKSA 389

Query: 144 PATPKTTTPPSSPPPTAVSPE 164
           P TPK   P ++  P   +P+
Sbjct: 390 PTTPKEPAPTTTKEPAPTTPK 410



 Score = 29.3 bits (64), Expect = 8.6
 Identities = 32/136 (23%), Positives = 47/136 (34%), Gaps = 17/136 (12%)

Query: 51  TTMDIKDLVKQFHQIKVEKWSEGTTPQKKLECLKEPGKTSVESKVPTQ--MEKSTDTDED 108
           TT++ K+      Q   +   E TT  K+ + ++   KTS +   PT   + K T   E 
Sbjct: 282 TTVETKETTTTNKQTSTDG-KEKTTSAKETQSIE---KTSAKDLAPTSKVLAKPTPKAET 337

Query: 109 NVTRTEYSDKTTQFPSVYAVPG--TEQTEAVGGLSSKPATPKTTTP---------PSSPP 157
                  +      P+    P   T +      + S P TPK   P         P  P 
Sbjct: 338 TTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPA 397

Query: 158 PTAVSPEFAYVPADPA 173
           PT         P +PA
Sbjct: 398 PTTTKEPAPTTPKEPA 413


>gi|239743293 PREDICTED: mucin 12 [Homo sapiens]
          Length = 5478

 Score = 38.9 bits (89), Expect = 0.011
 Identities = 76/377 (20%), Positives = 124/377 (32%), Gaps = 24/377 (6%)

Query: 116  SDKTTQFPSVYAVPGTEQTEAVGGLSSKPATPKTTTPPSSPPPTAVSPEFAYVPADPAQL 175
            S  TT FP    +PG  Q        S P +  TT  P S   +++ PE     + P   
Sbjct: 1728 STHTTAFPGSTTMPGVSQESTAS--HSSPGSTDTTLSPGSTTASSLGPESTTFHSSPGST 1785

Query: 176  AAQMLGKVSSIHSDQSDVLMVDVATSMPVVIKEVPSSEAAEDVMVAAPLVCSGKVLEVQV 235
               +L   ++          V  +T  P        S   +          S K      
Sbjct: 1786 ETTLLPDNTTASGLLEASTPVHSSTGSPHTTLSPAGSTTRQGESTTFQSWPSSKDTMPAP 1845

Query: 236  VNQTSVHVDLGS----QPKENEAEPSTASSVPLQDEQEPPAYDQAPEVTLQADIEVMST- 290
               TS  V+L +     P        +ASS  L   +E      +P  T        ST 
Sbjct: 1846 PTTTSAFVELSTTSHGSPSSTPTTHFSASSTTLGRSEESTTVHSSPVATATTPSPARSTT 1905

Query: 291  ---VHISSVYNDVPVTEGVVYIEQLPEQIVIPFTDQVACLKENEQSKENEQSPRVSPKSV 347
               V  S+ Y+  P   G       PE        + +    +  +     SP  +  ++
Sbjct: 1906 SGLVEESTAYHSSP---GSTQTMHFPESSTASGRSEES-RTSHSSTTHTISSPPSTTSAL 1961

Query: 348  VEKTTSGMSKKSVESVKLAQLEENAKYSSVYMEAEATALLSDTSLKGQPEVPAQLLDAEG 407
            VE+ TS  S  S  S       +++  S      E+TA  S     G   +PA+   +  
Sbjct: 1962 VEEPTSYHS--SPGSTATTHFPDSSTTSG--RSEESTASHSSQDATGTIVLPAR---STT 2014

Query: 408  AIKIGSEKSLHL---EVEITSIVSDNTGQEESGENSVPQEMEGKPVLSGEAAEAVHSGTS 464
            ++ +G   +  +    +E T++    T    S +++        P  +   A    SG S
Sbjct: 2015 SVLLGESTTSPISSGSMETTALPGSTTTPGLSEKSTTFHSSPRSPATTLSPASTTSSGVS 2074

Query: 465  VKSSSGPFPPAPEGLTA 481
             +S++    P     TA
Sbjct: 2075 EESTTSHSRPGSTHTTA 2091



 Score = 38.1 bits (87), Expect = 0.018
 Identities = 72/377 (19%), Positives = 119/377 (31%), Gaps = 24/377 (6%)

Query: 116  SDKTTQFPSVYAVPGTEQTEAVGGLSSKPATPKTTTPPSSPPPTAVSPEFAYVPADPAQL 175
            S  TT FP    +PG  Q        S P +  TT  P S   +++ PE     + P   
Sbjct: 3285 STHTTAFPGSTTMPGVSQESTAS--HSSPGSTDTTLSPGSTTASSLGPESTTFHSGPGST 3342

Query: 176  AAQMLGKVSSIHSDQSDVLMVDVATSMPVVIKEVPSSEAAEDVMVAAPLVCSGKVLEVQV 235
               +L   ++          V  +T  P        S   +          + K      
Sbjct: 3343 ETTLLPDNTTASGLLEASTPVHSSTGSPHTTLSPAGSTTRQGESTTFQSWPNSKDTTPAP 3402

Query: 236  VNQTSVHVDLGS----QPKENEAEPSTASSVPLQDEQEPPAYDQAPEVTLQADIEVMST- 290
               TS  V+L +     P        +ASS  L   +E      +P  T        ST 
Sbjct: 3403 PTTTSAFVELSTTSHGSPSSTPTTHFSASSTTLGRSEESTTVHSSPVATATTPSPARSTT 3462

Query: 291  ---VHISSVYNDVPVTEGVVYIEQLPEQIVIPFTDQVACLKENEQSKENEQSPRVSPKSV 347
               V  S+ Y+  P   G       PE        + +    +  +     +P  +   V
Sbjct: 3463 SGLVEESTTYHSSP---GSTQTMHFPESDTTSGRGEESTTSHSSTTHTISSAPSTTSALV 3519

Query: 348  VEKTTSGMSKKSVESVKLAQLEENAKYSSVYMEAEATALLSDTSLKGQPEVPAQLLDAEG 407
             E T+   S  S  +         +  S      E+TA  S     G   +PA+   +  
Sbjct: 3520 EEPTSYHSSPGSTATTHFPDSSTTSGRSE-----ESTASHSSQDATGTIVLPAR---STT 3571

Query: 408  AIKIGSEKSLHL---EVEITSIVSDNTGQEESGENSVPQEMEGKPVLSGEAAEAVHSGTS 464
            ++ +G   +  +    +E T++    T    S +++        P  +   A    SG S
Sbjct: 3572 SVLLGESTTSPISSGSMETTALPGSTTTPGLSEKSTTFHSSPRSPATTLSPASTTSSGVS 3631

Query: 465  VKSSSGPFPPAPEGLTA 481
             +S++    P     TA
Sbjct: 3632 EESTTSHSRPGSTHTTA 3648



 Score = 35.0 bits (79), Expect = 0.16
 Identities = 79/367 (21%), Positives = 125/367 (34%), Gaps = 83/367 (22%)

Query: 119  TTQFPSVYAVPGTEQTEAVGGLSSKPATPKTTTPPSSPPPTAVSPEFAYVPADPAQLAAQ 178
            TT FPS   +PG  Q        S P +  TT  P S   +++ PE     + P      
Sbjct: 4371 TTAFPSSTTMPGVSQESTAS--HSSPGSTDTTLSPGSTTASSLGPESTTFHSSPGSTETT 4428

Query: 179  MLGKVSSIHSDQSDVLMVDVATSMPVVIKEVPSSEAAEDVMVAAPLVCSGKVLEVQVVNQ 238
            +L                             P +  A  ++ A+  V S         + 
Sbjct: 4429 LL-----------------------------PDNTTASGLLEASTPVHS---------ST 4450

Query: 239  TSVHVDL---GSQPKENEAEPSTASSVPLQDEQEPPAYDQAPEVTLQADIEVMSTVHISS 295
             S H  L   GS  ++ E+  +T  S P   +  P     AP  T  A +E+ +T H S 
Sbjct: 4451 GSPHTTLSPAGSTTRQGES--TTFQSWPNSKDTTP-----APPTTTSAFVELSTTSHGSP 4503

Query: 296  VYNDVPVTEGVVYIEQLPEQIVIPFTDQVACLKENEQSKENEQSP--RVSPKSVVEKTTS 353
              +  P T                F+     L  +E+S     SP    +  S    TTS
Sbjct: 4504 --SSTPTTH---------------FSASSTTLGRSEESTTVHSSPVATATTPSPARSTTS 4546

Query: 354  GMSKKSVE------SVKLAQLEENAKYSSVYMEAEATALLSDTSLKGQPEVPAQLLDAEG 407
            G+ ++S        S +     E+   S    E+  +   +  ++   P   + L++   
Sbjct: 4547 GLVEESTTYHSSPGSTQTMHFPESNTTSGRGEESTTSHSSTTHTISSAPSTTSALVEEPT 4606

Query: 408  AI--KIGSEKSLHLEVEITSIVSDNTGQEESGENSVPQEMEGKPVLSGEAAEAVHSGTSV 465
            +     GS  + H     T+    +   EES  +   Q+  G  VL   +  +V  G S 
Sbjct: 4607 SYHSSPGSTATTHFPDSSTT----SGRSEESTASHSSQDATGTIVLPARSTTSVLLGEST 4662

Query: 466  KS--SSG 470
             S  SSG
Sbjct: 4663 TSPISSG 4669



 Score = 33.9 bits (76), Expect = 0.35
 Identities = 81/413 (19%), Positives = 132/413 (31%), Gaps = 81/413 (19%)

Query: 95   VPTQMEKSTDTDEDNVTRTEY-SDKTTQFPSVYAVPGTEQTEAVGGLSSKPATPKTTTPP 153
            +P  M  S  ++E   + +   S  TT FP    +PG  Q        S P    TT  P
Sbjct: 651  LPASMTSSGVSEESTTSHSRPGSTHTTAFPGSTTMPGLSQESTAS--HSSPGPTDTTLSP 708

Query: 154  SSPPPTAVSPEFAYVPADPAQLAAQMLGKVSSIHSDQSDVLMVDVATSMPVVIKEVPSSE 213
             S   +++ PE+    + P      +L                             P + 
Sbjct: 709  GSTTASSLGPEYTTFHSRPGSTETTLL-----------------------------PDNT 739

Query: 214  AAEDVMVAAPLVCSGKVLEVQVVNQTSVHVDL---GSQPKENEAEPSTASSVPLQDEQEP 270
             A  ++ A+  V S         +  S H  L   GS  ++ E+  +T  S P   +  P
Sbjct: 740  TASGLLEASMPVHS---------STRSPHTTLSPAGSTTRQGES--TTFHSWPSSKDTRP 788

Query: 271  PAYDQAPEVTLQADIEVMSTVHISSVYNDVPVTEGVV------YIEQLPEQIVIPFTDQV 324
                 AP  T  A +E  +T H S   + +P T           +E+       P + Q 
Sbjct: 789  -----APPTTTSAFVEPSTTSHGSP--SSIPTTHISARSTTSGLVEESTTYHSSPGSTQT 841

Query: 325  ACLKENEQSKENEQSPRVSPKSVVEKTTSGMSKKSVESVKLAQLEENAKYSSVYMEAEAT 384
                E++ +    +    S  S     +S  S  S      A +EE   Y S       T
Sbjct: 842  MHFPESDTTSGRGEESTTSHSSTTHTISSAPSTTS------ALVEEPTSYHSSPGSTATT 895

Query: 385  ALLSDTSLKGQPE---VPAQLLDAEGAIKIGSEKSLHL-------------EVEITSIVS 428
                 ++  G+ E         DA G I + +  +  +              +E T++  
Sbjct: 896  HFPDSSTTSGRSEESTASHSSQDATGTIVLPARSTTSVLLGESTTSPISSGSMETTALPG 955

Query: 429  DNTGQEESGENSVPQEMEGKPVLSGEAAEAVHSGTSVKSSSGPFPPAPEGLTA 481
              T    S  ++        P  +   A    SG S +S++    P     TA
Sbjct: 956  STTTPGLSERSTTFHSSPRSPATTLSPASTTSSGVSEESTTSRSRPGSTHTTA 1008



 Score = 30.4 bits (67), Expect = 3.8
 Identities = 27/105 (25%), Positives = 42/105 (40%), Gaps = 5/105 (4%)

Query: 71   SEGTTP--QKKLECLKEPGKTSVESKVPTQMEKSTDTDEDNVTRTEY-SDKTTQFPSVYA 127
            S  TTP    K   L    ++  ++  P  M  S+ + E     ++  S  TT FP+   
Sbjct: 4870 STATTPGLSAKSTILYSSSRSPDQTLSPASMTSSSISGEPTSLYSQAESTHTTAFPASTT 4929

Query: 128  VPGTEQTEAVGGLSSKPATPKTTTPPSSPPPTAVSPEFAYVPADP 172
              G  Q        SKP + +TT  P S   ++ + EF    + P
Sbjct: 4930 TSGLSQESTT--FHSKPGSTETTLSPGSITTSSFAQEFTTPHSQP 4972


>gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo
           sapiens]
          Length = 486

 Score = 38.9 bits (89), Expect = 0.011
 Identities = 68/327 (20%), Positives = 122/327 (37%), Gaps = 55/327 (16%)

Query: 69  KWSEGTTPQKKLECLKEPGKT--SVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVY 126
           K SE T   K+ +  K P +T  S +  +P   EK+    E N+ ++  S K  Q P + 
Sbjct: 39  KSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQPKESNIPKS--SAKPIQ-PKLG 95

Query: 127 AVPGTEQTEAVGGLSSKPATPKTTTPPSSPPPT--------------AVSPEFAYVPADP 172
            +P           S KP+ PK    P +P  T              A+ P+   +P   
Sbjct: 96  NIPKA---------SVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSS 146

Query: 173 AQLAAQMLGKVSSIHSDQSDVLMVDVATSMPVVIK----EVPSSEAAEDVMVAAPLVCSG 228
           A+     LG ++      S     D+  S    I+    ++P S              S 
Sbjct: 147 AKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGDIPKS--------------SA 192

Query: 229 KVLEVQVVNQTSVHVDLGSQPKENEAEPSTASSVPLQDEQEPPAYDQAPEVTLQADIEVM 288
           K ++ ++ N     V   SQPKE +   S   ++  ++   P + ++A +   + DI   
Sbjct: 193 KPIQPKLGNIPKASVK-PSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQ-PKEGDIPKS 250

Query: 289 STVHISSVYNDVPVT-EGVVY-----IEQLPEQIVIPFTDQVACLKENEQSKENEQSPRV 342
               I     D+P + E  +      I + PE+ + P    +    E     +    P+ 
Sbjct: 251 PEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAIQPKEGDIPK- 309

Query: 343 SPKSVVEKTTSGMSKKSVESVKLAQLE 369
           SPK  ++     + K   E++   +++
Sbjct: 310 SPKQAIQPKEGDIPKSLEEAIPPKEID 336



 Score = 36.2 bits (82), Expect = 0.070
 Identities = 63/272 (23%), Positives = 103/272 (37%), Gaps = 35/272 (12%)

Query: 94  KVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTEQTEAVGGLSSKPATPKTTTPP 153
           K P +  +S   D    +      K    P   A P   +   +   S KP+ PK +  P
Sbjct: 114 KAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIP 173

Query: 154 SSPPPTAVSPEFAYVPADPAQLAAQMLGKVSSIHSDQSDVLMVDVATSMPVVI--KEVPS 211
            SP  T + P+   +P   A+     LG +       S     D++ S    I  KE   
Sbjct: 174 KSPEET-IQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDL 232

Query: 212 SEAAEDVMVAAPLVCSGKVLEVQVVNQTSVHVDLGSQPKE-NEAEPSTASSVPLQDEQ-- 268
            ++ E+ +         K  ++    + ++    G  PK   EA       +P   E+  
Sbjct: 233 PKSLEEAI-------QPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETI 285

Query: 269 EPPAYD--QAPEVTLQ---ADIEVMSTVHISSVYNDVPVTEGVVYIEQL--PEQIVIPFT 321
           +P   D  ++PE  +Q    DI       I     D+P +     +E+   P++I IP +
Sbjct: 286 QPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKS-----LEEAIPPKEIDIPKS 340

Query: 322 DQVACLKENEQSKENEQSPRVSPKSVVEKTTS 353
            +     E  Q KE++     SPKS+ E T S
Sbjct: 341 PE-----ETIQPKEDD-----SPKSLEEATPS 362


>gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo
           sapiens]
          Length = 553

 Score = 38.9 bits (89), Expect = 0.011
 Identities = 68/327 (20%), Positives = 122/327 (37%), Gaps = 55/327 (16%)

Query: 69  KWSEGTTPQKKLECLKEPGKT--SVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVY 126
           K SE T   K+ +  K P +T  S +  +P   EK+    E N+ ++  S K  Q P + 
Sbjct: 106 KSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQPKESNIPKS--SAKPIQ-PKLG 162

Query: 127 AVPGTEQTEAVGGLSSKPATPKTTTPPSSPPPT--------------AVSPEFAYVPADP 172
            +P           S KP+ PK    P +P  T              A+ P+   +P   
Sbjct: 163 NIPKA---------SVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSS 213

Query: 173 AQLAAQMLGKVSSIHSDQSDVLMVDVATSMPVVIK----EVPSSEAAEDVMVAAPLVCSG 228
           A+     LG ++      S     D+  S    I+    ++P S              S 
Sbjct: 214 AKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGDIPKS--------------SA 259

Query: 229 KVLEVQVVNQTSVHVDLGSQPKENEAEPSTASSVPLQDEQEPPAYDQAPEVTLQADIEVM 288
           K ++ ++ N     V   SQPKE +   S   ++  ++   P + ++A +   + DI   
Sbjct: 260 KPIQPKLGNIPKASVK-PSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQ-PKEGDIPKS 317

Query: 289 STVHISSVYNDVPVT-EGVVY-----IEQLPEQIVIPFTDQVACLKENEQSKENEQSPRV 342
               I     D+P + E  +      I + PE+ + P    +    E     +    P+ 
Sbjct: 318 PEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAIQPKEGDIPK- 376

Query: 343 SPKSVVEKTTSGMSKKSVESVKLAQLE 369
           SPK  ++     + K   E++   +++
Sbjct: 377 SPKQAIQPKEGDIPKSLEEAIPPKEID 403



 Score = 36.2 bits (82), Expect = 0.070
 Identities = 63/272 (23%), Positives = 103/272 (37%), Gaps = 35/272 (12%)

Query: 94  KVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTEQTEAVGGLSSKPATPKTTTPP 153
           K P +  +S   D    +      K    P   A P   +   +   S KP+ PK +  P
Sbjct: 181 KAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIP 240

Query: 154 SSPPPTAVSPEFAYVPADPAQLAAQMLGKVSSIHSDQSDVLMVDVATSMPVVI--KEVPS 211
            SP  T + P+   +P   A+     LG +       S     D++ S    I  KE   
Sbjct: 241 KSPEET-IQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDL 299

Query: 212 SEAAEDVMVAAPLVCSGKVLEVQVVNQTSVHVDLGSQPKE-NEAEPSTASSVPLQDEQ-- 268
            ++ E+ +         K  ++    + ++    G  PK   EA       +P   E+  
Sbjct: 300 PKSLEEAI-------QPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETI 352

Query: 269 EPPAYD--QAPEVTLQ---ADIEVMSTVHISSVYNDVPVTEGVVYIEQL--PEQIVIPFT 321
           +P   D  ++PE  +Q    DI       I     D+P +     +E+   P++I IP +
Sbjct: 353 QPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKS-----LEEAIPPKEIDIPKS 407

Query: 322 DQVACLKENEQSKENEQSPRVSPKSVVEKTTS 353
            +     E  Q KE++     SPKS+ E T S
Sbjct: 408 PE-----ETIQPKEDD-----SPKSLEEATPS 429


>gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo
           sapiens]
          Length = 486

 Score = 38.9 bits (89), Expect = 0.011
 Identities = 68/327 (20%), Positives = 122/327 (37%), Gaps = 55/327 (16%)

Query: 69  KWSEGTTPQKKLECLKEPGKT--SVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVY 126
           K SE T   K+ +  K P +T  S +  +P   EK+    E N+ ++  S K  Q P + 
Sbjct: 39  KSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQPKESNIPKS--SAKPIQ-PKLG 95

Query: 127 AVPGTEQTEAVGGLSSKPATPKTTTPPSSPPPT--------------AVSPEFAYVPADP 172
            +P           S KP+ PK    P +P  T              A+ P+   +P   
Sbjct: 96  NIPKA---------SVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSS 146

Query: 173 AQLAAQMLGKVSSIHSDQSDVLMVDVATSMPVVIK----EVPSSEAAEDVMVAAPLVCSG 228
           A+     LG ++      S     D+  S    I+    ++P S              S 
Sbjct: 147 AKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGDIPKS--------------SA 192

Query: 229 KVLEVQVVNQTSVHVDLGSQPKENEAEPSTASSVPLQDEQEPPAYDQAPEVTLQADIEVM 288
           K ++ ++ N     V   SQPKE +   S   ++  ++   P + ++A +   + DI   
Sbjct: 193 KPIQPKLGNIPKASVK-PSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQ-PKEGDIPKS 250

Query: 289 STVHISSVYNDVPVT-EGVVY-----IEQLPEQIVIPFTDQVACLKENEQSKENEQSPRV 342
               I     D+P + E  +      I + PE+ + P    +    E     +    P+ 
Sbjct: 251 PEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAIQPKEGDIPK- 309

Query: 343 SPKSVVEKTTSGMSKKSVESVKLAQLE 369
           SPK  ++     + K   E++   +++
Sbjct: 310 SPKQAIQPKEGDIPKSLEEAIPPKEID 336



 Score = 36.2 bits (82), Expect = 0.070
 Identities = 63/272 (23%), Positives = 103/272 (37%), Gaps = 35/272 (12%)

Query: 94  KVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTEQTEAVGGLSSKPATPKTTTPP 153
           K P +  +S   D    +      K    P   A P   +   +   S KP+ PK +  P
Sbjct: 114 KAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIP 173

Query: 154 SSPPPTAVSPEFAYVPADPAQLAAQMLGKVSSIHSDQSDVLMVDVATSMPVVI--KEVPS 211
            SP  T + P+   +P   A+     LG +       S     D++ S    I  KE   
Sbjct: 174 KSPEET-IQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDL 232

Query: 212 SEAAEDVMVAAPLVCSGKVLEVQVVNQTSVHVDLGSQPKE-NEAEPSTASSVPLQDEQ-- 268
            ++ E+ +         K  ++    + ++    G  PK   EA       +P   E+  
Sbjct: 233 PKSLEEAI-------QPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETI 285

Query: 269 EPPAYD--QAPEVTLQ---ADIEVMSTVHISSVYNDVPVTEGVVYIEQL--PEQIVIPFT 321
           +P   D  ++PE  +Q    DI       I     D+P +     +E+   P++I IP +
Sbjct: 286 QPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKS-----LEEAIPPKEIDIPKS 340

Query: 322 DQVACLKENEQSKENEQSPRVSPKSVVEKTTS 353
            +     E  Q KE++     SPKS+ E T S
Sbjct: 341 PE-----ETIQPKEDD-----SPKSLEEATPS 362


>gi|148613886 regulatory factor X domain containing 2 [Homo sapiens]
          Length = 1460

 Score = 38.5 bits (88), Expect = 0.014
 Identities = 84/396 (21%), Positives = 147/396 (37%), Gaps = 64/396 (16%)

Query: 130 GTEQTEAVGGLSSKPATPKTTTPPSSPPPTAVS----PEFAYVPADPAQLAAQMLGKVSS 185
           GT+   A+  +++ PA  K  T PS+  PTA S    P+   +P+ P     Q+  K+  
Sbjct: 255 GTKSMAALTVMAAAPAGMKGITQPSAFIPTAESNSFQPQVKTLPS-PIDAKQQLQRKIQK 313

Query: 186 IHSDQ--------------SDVLMVDVATSMP-------------VVIKEVPSSEAAEDV 218
              +Q              S+    +  T++P             +V+  VPS    +  
Sbjct: 314 KQQEQKLQSPLPGESAAKKSESATSNGVTNLPNGNPSILSPQPIGIVVAAVPSPIPVQRT 373

Query: 219 --MVAAPLVCS---GKV--LEVQVVNQTSVHVDLGSQPKEN-EAEPSTASSVPLQDEQEP 270
             +V +P   S   GKV  L VQVV Q    V    +  +N  A P    S   +  Q  
Sbjct: 374 RQLVTSPSPMSSSDGKVLPLNVQVVTQHMQSVKQAPKTPQNVPASPGGDRSARHRYPQIL 433

Query: 271 PAYDQAPEVTLQADIEVMST-----------VHISSVYNDVPVTEGVVYIEQLPEQIVIP 319
           P       +T+++   V+ T            H+SS+ N V +T     I   P     P
Sbjct: 434 PKPANTSALTIRSPTTVLFTSSPIKTAVVPASHMSSL-NVVKMTT----ISLTPSNSNTP 488

Query: 320 FTDQVACLKENEQSKENEQSPRVSPKSVVEKTTSGMSKKSVESVKLAQLEENAKYSSVYM 379
                +       ++E+   P++   SVV   + G    S       +++   + SS   
Sbjct: 489 LKHSASVSSATGTTEESRSVPQIKNGSVVSLQSPGSRSSSAGGTSAVEVKVEPETSS--- 545

Query: 380 EAEATALLSDTSLKGQPEVPAQLL----DAEGAIKIGSEKSLHLEVEITSIVSDNTGQEE 435
           +        ++     P+ P+ LL    + +GA++  S + + +E++ T +    T  + 
Sbjct: 546 DEHPVQCQENSDEAKAPQTPSALLGQKSNTDGALQKPSNEGV-IEIKATKVCDQRTKCKS 604

Query: 436 SGENSVPQEMEGKPVLSGEAAEAVHSGTSVKSSSGP 471
                +P    G    +   + A  + T   SSS P
Sbjct: 605 RCNEMLPGTSTGNNQSTITLSVASQNLTFTSSSSPP 640


>gi|33350928 disabled homolog 1 [Homo sapiens]
          Length = 555

 Score = 38.1 bits (87), Expect = 0.018
 Identities = 56/236 (23%), Positives = 90/236 (38%), Gaps = 39/236 (16%)

Query: 53  MDIKDLVKQFHQIKVEKWSEGTTPQKKLECLKEPGKTSVESKV--PTQMEKSTDTDEDNV 110
           +D++DL +  +++K  +  E    QK  +C +   +T +E  V  P       +   + +
Sbjct: 152 LDLRDLFQLIYELKQREELEKKA-QKDKQCEQAVYQTILEEDVEDPVYQYIVFEAGHEPI 210

Query: 111 TRTEYSDKTTQFPS------VYAVPGTEQTEAVGGLSSKPATPKTTTPPSSPPPTAVSPE 164
              E  +   Q P+      VY VP ++   AV  L        +T P  + PPT  +P 
Sbjct: 211 RDPETEENIYQVPTSQKKEGVYDVPKSQPVSAVTQLEL--FGDMSTPPDITSPPTPATPG 268

Query: 165 FAYVPADPAQLAAQMLGKVSSIHSDQSDVLMVDVATSMPVVIKEVPSSEAAEDVMVAA-- 222
            A++P+    L A                   DV +S+P     VPS   A   ++ +  
Sbjct: 269 DAFIPSSSQTLPAS-----------------ADVFSSVPFGTAAVPSGYVAMGAVLPSFW 311

Query: 223 ---PLVCSGKVLEVQVVNQTSVHVDLGSQP---KENEAEPSTASSVPLQDEQEPPA 272
              PLV    V+  Q        V  G+QP    +    P+T    P    Q PPA
Sbjct: 312 GQQPLVQQQMVMGAQ---PPVAQVMPGAQPIAWGQPGLFPATQQPWPTVAGQFPPA 364


>gi|21264565 AT rich interactive domain 1A isoform a [Homo sapiens]
          Length = 2285

 Score = 38.1 bits (87), Expect = 0.018
 Identities = 64/273 (23%), Positives = 109/273 (39%), Gaps = 46/273 (16%)

Query: 249 PKENEAEPSTASSVPLQDEQEPPAYDQAPEVTLQADIEVMSTVHISSVYNDVPVTEGVVY 308
           P   + +P  +   P Q     P+Y Q P+       ++ S+      Y+  P       
Sbjct: 476 PHPQQQQPPYSQQPPSQTPHAQPSYQQQPQ---SQPPQLQSS---QPPYSQQP------- 522

Query: 309 IEQLP-EQIVIPFTDQVACLKENEQSKE-----------NEQSPRVSPKSVVEKTTSGMS 356
             Q P +Q   P+  Q +  +++ QS+             +Q P+    S + +  +   
Sbjct: 523 -SQPPHQQSPAPYPSQQSTTQQHPQSQPPYSQPQAQSPYQQQQPQQPAPSTLSQQAAYPQ 581

Query: 357 KKSVESVKLAQLEEN----AKYSSVYMEAEATALLSDTSLKGQPE--------VPAQLLD 404
            +S +S + A  ++      + S     ++A++  S TS KG  E         P+ L D
Sbjct: 582 PQSQQSQQTAYSQQRFPPPQELSQDSFGSQASSAPSMTSSKGGQEDMNLSLQSRPSSLPD 641

Query: 405 AEGAI---KIGSEKSLHLEVEITSIVSDNTGQEESGENS--VPQEMEGKPVLSGEAAEAV 459
             G+I    +G+E +L   V  TS +S + G++ +   S   P      P + G +   V
Sbjct: 642 LSGSIDDLPMGTEGALSPGVS-TSGISSSQGEQSNPAQSPFSPHTSPHLPGIRGPSPSPV 700

Query: 460 HSGTSV-KSSSGPFPPAP-EGLTAPEIEPEGES 490
            S  SV +S SGP  PA   G   P   P G+S
Sbjct: 701 GSPASVAQSRSGPLSPAAVPGNQMPPRPPSGQS 733


>gi|21264575 AT rich interactive domain 1A isoform b [Homo sapiens]
          Length = 2068

 Score = 38.1 bits (87), Expect = 0.018
 Identities = 64/273 (23%), Positives = 109/273 (39%), Gaps = 46/273 (16%)

Query: 249 PKENEAEPSTASSVPLQDEQEPPAYDQAPEVTLQADIEVMSTVHISSVYNDVPVTEGVVY 308
           P   + +P  +   P Q     P+Y Q P+       ++ S+      Y+  P       
Sbjct: 476 PHPQQQQPPYSQQPPSQTPHAQPSYQQQPQ---SQPPQLQSS---QPPYSQQP------- 522

Query: 309 IEQLP-EQIVIPFTDQVACLKENEQSKE-----------NEQSPRVSPKSVVEKTTSGMS 356
             Q P +Q   P+  Q +  +++ QS+             +Q P+    S + +  +   
Sbjct: 523 -SQPPHQQSPAPYPSQQSTTQQHPQSQPPYSQPQAQSPYQQQQPQQPAPSTLSQQAAYPQ 581

Query: 357 KKSVESVKLAQLEEN----AKYSSVYMEAEATALLSDTSLKGQPE--------VPAQLLD 404
            +S +S + A  ++      + S     ++A++  S TS KG  E         P+ L D
Sbjct: 582 PQSQQSQQTAYSQQRFPPPQELSQDSFGSQASSAPSMTSSKGGQEDMNLSLQSRPSSLPD 641

Query: 405 AEGAI---KIGSEKSLHLEVEITSIVSDNTGQEESGENS--VPQEMEGKPVLSGEAAEAV 459
             G+I    +G+E +L   V  TS +S + G++ +   S   P      P + G +   V
Sbjct: 642 LSGSIDDLPMGTEGALSPGVS-TSGISSSQGEQSNPAQSPFSPHTSPHLPGIRGPSPSPV 700

Query: 460 HSGTSV-KSSSGPFPPAP-EGLTAPEIEPEGES 490
            S  SV +S SGP  PA   G   P   P G+S
Sbjct: 701 GSPASVAQSRSGPLSPAAVPGNQMPPRPPSGQS 733


>gi|237681125 breast cancer 1, early onset isoform 5 [Homo sapiens]
          Length = 699

 Score = 37.7 bits (86), Expect = 0.024
 Identities = 59/263 (22%), Positives = 105/263 (39%), Gaps = 66/263 (25%)

Query: 238 QTSVHVDLGSQPKENEAEPSTASSVPLQDEQEPPAYDQAPEVTLQA---------DIEVM 288
           +TSV+++LGS   E+    +T  SV  Q+  +        E++L +         + +V 
Sbjct: 175 KTSVYIELGSDSSEDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKKAACEFSETDVT 234

Query: 289 STVHISSVYNDVPVTEGVVYIEQLPEQIVIPFTDQVACLKENEQSKENEQSPRVSPKSVV 348
           +T H     ND+  TE     E+ PE+    +  + A   E+E S              V
Sbjct: 235 NTEHHQPSNNDLNTTEKRA-AERHPEK----YQGEAASGCESETS--------------V 275

Query: 349 EKTTSGMSKKSVESVKLAQLEENAKYSSVYMEAEATALLSDTSLKGQPEVPAQLLDAEGA 408
            +  SG+S +S   +   Q  +  +++ + ++ E   L +             +L+  G+
Sbjct: 276 SEDCSGLSSQS--DILTTQQRDTMQHNLIKLQQEMAELEA-------------VLEQHGS 320

Query: 409 IKIGSEKSLHLEVEITSIVSDNTGQEESGENSVPQEMEGKPVLSGEAAEAVHSGTSVKSS 468
               S           SI+SD++  E+      P++   + VL           TS KSS
Sbjct: 321 QPSNS---------YPSIISDSSALEDLRN---PEQSTSEKVL-----------TSQKSS 357

Query: 469 SGPFPPAPEGLTAPEIEPEGEST 491
             P    PEGL+A + E   +S+
Sbjct: 358 EYPISQNPEGLSADKFEVSADSS 380


>gi|237681123 breast cancer 1, early onset isoform 4 [Homo sapiens]
          Length = 759

 Score = 37.7 bits (86), Expect = 0.024
 Identities = 59/263 (22%), Positives = 105/263 (39%), Gaps = 66/263 (25%)

Query: 238 QTSVHVDLGSQPKENEAEPSTASSVPLQDEQEPPAYDQAPEVTLQA---------DIEVM 288
           +TSV+++LGS   E+    +T  SV  Q+  +        E++L +         + +V 
Sbjct: 175 KTSVYIELGSDSSEDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKKAACEFSETDVT 234

Query: 289 STVHISSVYNDVPVTEGVVYIEQLPEQIVIPFTDQVACLKENEQSKENEQSPRVSPKSVV 348
           +T H     ND+  TE     E+ PE+    +  + A   E+E S              V
Sbjct: 235 NTEHHQPSNNDLNTTEKRA-AERHPEK----YQGEAASGCESETS--------------V 275

Query: 349 EKTTSGMSKKSVESVKLAQLEENAKYSSVYMEAEATALLSDTSLKGQPEVPAQLLDAEGA 408
            +  SG+S +S   +   Q  +  +++ + ++ E   L +             +L+  G+
Sbjct: 276 SEDCSGLSSQS--DILTTQQRDTMQHNLIKLQQEMAELEA-------------VLEQHGS 320

Query: 409 IKIGSEKSLHLEVEITSIVSDNTGQEESGENSVPQEMEGKPVLSGEAAEAVHSGTSVKSS 468
               S           SI+SD++  E+      P++   + VL           TS KSS
Sbjct: 321 QPSNS---------YPSIISDSSALEDLRN---PEQSTSEKVL-----------TSQKSS 357

Query: 469 SGPFPPAPEGLTAPEIEPEGEST 491
             P    PEGL+A + E   +S+
Sbjct: 358 EYPISQNPEGLSADKFEVSADSS 380


>gi|11641239 hypothetical protein LOC53838 [Homo sapiens]
          Length = 449

 Score = 37.7 bits (86), Expect = 0.024
 Identities = 46/170 (27%), Positives = 67/170 (39%), Gaps = 20/170 (11%)

Query: 116 SDKTTQFPSVYAVPGTEQTEAVGGLSSKPATPKTTTPPSSPPPTAVSPEFAYVPADPA-- 173
           S    Q P   A+P   +T  +  L+++  T  TT   SSP  T  SP   ++P+D A  
Sbjct: 189 STALAQVPKSSALP---RTATLATLATRAQTVATTANTSSPMSTRPSPS-KHMPSDTAAS 244

Query: 174 ---QLAAQMLGKVSSIHSDQSDVLMVDVATSMPVVIKEVPSSEAAEDVMVAAPLVCSGKV 230
               +  Q  G +S +  DQ  V   + +T MP      P+           P V +   
Sbjct: 245 PVPPMRPQAQGPISQVSVDQPVVNTTNKSTPMPSNTTPEPA---------PTPTVVTTTK 295

Query: 231 LEVQVVNQTSVHVDLGSQPKENEA-EPST-ASSVPLQDEQEPPAYDQAPE 278
            + +    + V V   S   E EA  P+T  S +P       P   QAPE
Sbjct: 296 AQAREPTASPVPVPHTSPIPEMEAMSPTTQPSPMPYTQRAAGPGTSQAPE 345



 Score = 32.0 bits (71), Expect = 1.3
 Identities = 46/207 (22%), Positives = 74/207 (35%), Gaps = 15/207 (7%)

Query: 94  KVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTEQ--TEAVGGL---SSKPATPK 148
           +V T+    TD  E   +       T+  P+  A   T    T A   +   SS P T  
Sbjct: 78  EVTTEDTSRTDVSEPATSGGAADGVTSIAPTAVASSTTAASITTAASSMTVASSAPTTAA 137

Query: 149 TTTPPSSPPPTAVSPEFAYVPADPAQLAAQMLGKVSSIHSDQSDVLMVDVATSMPVVIKE 208
           ++T  +S  PT  +       + P  LA   L   +S  + ++         S+   + +
Sbjct: 138 SSTTVASIAPTTAASSMTAASSTPMTLA---LPAPTSTSTGRTPSTTATGHPSLSTALAQ 194

Query: 209 VPSSEAAEDVMVAAPLVCSGKVLEVQVVNQTSVHVDLGSQPKENEAEPSTASSVPLQDEQ 268
           VP S A       A L    +   V     TS  +     P ++    + AS VP    Q
Sbjct: 195 VPKSSALPRTATLATLATRAQT--VATTANTSSPMSTRPSPSKHMPSDTAASPVPPMRPQ 252

Query: 269 EPPAYDQAPEVTLQADIEVMSTVHISS 295
                 Q P   +  D  V++T + S+
Sbjct: 253 A-----QGPISQVSVDQPVVNTTNKST 274


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.304    0.122    0.328 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,039,075
Number of Sequences: 37866
Number of extensions: 992052
Number of successful extensions: 6259
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 54
Number of HSP's successfully gapped in prelim test: 272
Number of HSP's that attempted gapping in prelim test: 5273
Number of HSP's gapped (non-prelim): 1157
length of query: 493
length of database: 18,247,518
effective HSP length: 106
effective length of query: 387
effective length of database: 14,233,722
effective search space: 5508450414
effective search space used: 5508450414
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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