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Search of human proteins with 24431950
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
(522 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 1077 0.0
gi|32189425 WD repeat domain 69 [Homo sapiens] 162 9e-40
gi|23199987 WD repeat domain 5B [Homo sapiens] 137 2e-32
gi|16554629 WD repeat domain 5 [Homo sapiens] 135 9e-32
gi|16554627 WD repeat domain 5 [Homo sapiens] 135 9e-32
gi|26665869 WD repeat domain 51B [Homo sapiens] 131 1e-30
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 130 2e-30
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 122 6e-28
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 122 6e-28
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 122 6e-28
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [... 121 2e-27
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [... 119 5e-27
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 117 3e-26
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 115 1e-25
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 115 1e-25
gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom... 114 2e-25
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H... 112 1e-24
gi|21071067 TBP-associated factor 5 [Homo sapiens] 112 1e-24
gi|113865883 WD repeat domain 38 [Homo sapiens] 110 2e-24
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 110 3e-24
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 109 7e-24
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 109 7e-24
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 106 6e-23
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 105 1e-22
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 104 2e-22
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is... 103 5e-22
gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i... 103 5e-22
gi|13376840 WD repeat domain 61 [Homo sapiens] 101 2e-21
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 100 2e-21
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 100 2e-21
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 1077 bits (2786), Expect = 0.0
Identities = 522/522 (100%), Positives = 522/522 (100%)
Query: 1 MASSRASSTQATKTKAPDDLVAPVVKKPHIYYGSLEEKERERLAKGESGILGKDGLKAGI 60
MASSRASSTQATKTKAPDDLVAPVVKKPHIYYGSLEEKERERLAKGESGILGKDGLKAGI
Sbjct: 1 MASSRASSTQATKTKAPDDLVAPVVKKPHIYYGSLEEKERERLAKGESGILGKDGLKAGI 60
Query: 61 EAGNINITSGEVFEIEEHISERQAEVLAEFERRKRARQINVSTDDSEVKACLRALGEPIT 120
EAGNINITSGEVFEIEEHISERQAEVLAEFERRKRARQINVSTDDSEVKACLRALGEPIT
Sbjct: 61 EAGNINITSGEVFEIEEHISERQAEVLAEFERRKRARQINVSTDDSEVKACLRALGEPIT 120
Query: 121 LFGEGPAERRERLRNILSVVGTDALKKTKKDDEKSKKSKEEYQQTWYHEGPNSLKVARLW 180
LFGEGPAERRERLRNILSVVGTDALKKTKKDDEKSKKSKEEYQQTWYHEGPNSLKVARLW
Sbjct: 121 LFGEGPAERRERLRNILSVVGTDALKKTKKDDEKSKKSKEEYQQTWYHEGPNSLKVARLW 180
Query: 181 IANYSLPRAMKRLEEARLHKEIPETTRTSQMQELHKSLRSLNNFCSQIGDDRPISYCHFS 240
IANYSLPRAMKRLEEARLHKEIPETTRTSQMQELHKSLRSLNNFCSQIGDDRPISYCHFS
Sbjct: 181 IANYSLPRAMKRLEEARLHKEIPETTRTSQMQELHKSLRSLNNFCSQIGDDRPISYCHFS 240
Query: 241 PNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCA 300
PNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCA
Sbjct: 241 PNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCA 300
Query: 301 ADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILH 360
ADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILH
Sbjct: 301 ADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILH 360
Query: 361 QEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGY 420
QEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGY
Sbjct: 361 QEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGY 420
Query: 421 HIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHP 480
HIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHP
Sbjct: 421 HIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHP 480
Query: 481 GWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE 522
GWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE
Sbjct: 481 GWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE 522
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 162 bits (409), Expect = 9e-40
Identities = 85/280 (30%), Positives = 140/280 (50%), Gaps = 9/280 (3%)
Query: 240 SPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASC 299
+P +AT + CKLWSV HT RGH + + F+P+ST+ +A+
Sbjct: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTL--------VATG 195
Query: 300 AADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEIL 359
+ D + KLW + + E V + GH+ + + ++ SG + T +D + +WD + ++
Sbjct: 196 SMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVN 255
Query: 360 HQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNG 419
GH + +F+ D SL TG +D ++WD G+C+ L GH EI F G
Sbjct: 256 ILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTG 315
Query: 420 YHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTH 479
IAT S D T +++ R+C+ + H+ ++ + F P GN LLTG+ D TA+IW
Sbjct: 316 KLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNP-QGNHLLTGSSDKTARIWDA 374
Query: 480 PGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
L+ L GH ++ + G ++ T S D T ++W
Sbjct: 375 QTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 152 bits (384), Expect = 7e-37
Identities = 86/290 (29%), Positives = 141/290 (48%), Gaps = 8/290 (2%)
Query: 233 PISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPK 292
P++ + + T + CKLW L+TL GH V AI F+ +P
Sbjct: 94 PLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN-------NPY 146
Query: 293 DVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDL 352
+A+ + D + KLWS+++ + GHT + + ++P + T D + +LWD+
Sbjct: 147 GDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDI 206
Query: 353 EAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYG 412
+ EE+ GHS + ++F+ G TG D VWD TGR + L GH EI
Sbjct: 207 QNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISS 266
Query: 413 INFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDN 472
+F+ + I TGS D TCK+WD +CV T+ H + + F+ G + T + D
Sbjct: 267 ASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFD-YTGKLIATASADG 325
Query: 473 TAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE 522
TA+I++ + L GHEG++ + + G + T S D+T ++W A+
Sbjct: 326 TARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQ 375
Score = 127 bits (318), Expect = 3e-29
Identities = 69/204 (33%), Positives = 105/204 (51%), Gaps = 2/204 (0%)
Query: 319 IEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQD-G 377
++ H + + V + SG T YDR+ +LWD + EE+ EGH VY IAF+ G
Sbjct: 88 LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYG 147
Query: 378 SLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLR 437
TG D ++W + TG+C GH EI ++F+P +ATGS D T K+WD++
Sbjct: 148 DKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQ 207
Query: 438 QRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMG 497
VYT+ H + + F G+ ++TG++D+T +W + L GH ++
Sbjct: 208 NGEEVYTLRGHSAEIISLSFN-TSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISS 266
Query: 498 LDISSDGQLIATCSYDRTFKLWMA 521
+ D LI T S D+T KLW A
Sbjct: 267 ASFNWDCSLILTGSMDKTCKLWDA 290
Score = 105 bits (261), Expect = 1e-22
Identities = 63/230 (27%), Positives = 105/230 (45%), Gaps = 34/230 (14%)
Query: 239 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKS----TVSLDPK-- 292
F+P S ++AT KLW + + ++TLRGH+ + ++ F+ T S D
Sbjct: 185 FNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVV 244
Query: 293 ----------DVNLASCAA------------------DGSVKLWSLDSDEPVADIEGHTV 324
++ + CA D + KLW + + VA + GH
Sbjct: 245 VWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDD 304
Query: 325 RVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGG 384
+ + +G+ + T D + R++ ++ I EGH + I+F+ G+ TG
Sbjct: 305 EILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGS 364
Query: 385 LDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVW 434
D R+WD +TG+C+ LEGH EI+ F+ G + TGS DNTC++W
Sbjct: 365 SDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 79.3 bits (194), Expect = 8e-15
Identities = 44/165 (26%), Positives = 82/165 (49%), Gaps = 8/165 (4%)
Query: 228 IGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTV 287
IG IS F+ + ++ T CKLW + + TL GH+ + F
Sbjct: 258 IGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCF------ 311
Query: 288 SLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSW 347
D +A+ +ADG+ +++S + + +A +EGH ++++ ++P G L T D++
Sbjct: 312 --DYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTA 369
Query: 348 RLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVW 392
R+WD + + + EGH+ ++ AF+ G++ TG D R+W
Sbjct: 370 RIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 137 bits (346), Expect = 2e-32
Identities = 84/302 (27%), Positives = 145/302 (48%), Gaps = 13/302 (4%)
Query: 225 CSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPK 284
C+ +G +S FSPN + LA++ L +W D TL GHN + + +
Sbjct: 35 CTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSD 94
Query: 285 STVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYD 344
S+ L S + D ++KLW + S + + ++GH+ V ++P + + +D
Sbjct: 95 SS--------RLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFD 146
Query: 345 RSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFL- 403
+ ++W+++ + + HS V + F+ GSL +G D R+WD +G+C+ L
Sbjct: 147 ETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLV 206
Query: 404 EGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQN--LVTGVKFEPIH 461
+ + + FSPNG +I T + DNT K+WD + RC+ T H+N F
Sbjct: 207 DDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTG 266
Query: 462 GNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSY--DRTFKLW 519
G ++++G+ DN IW ++ L GH V+ LIA+ + D+T KLW
Sbjct: 267 GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
Query: 520 MA 521
M+
Sbjct: 327 MS 328
Score = 122 bits (305), Expect = 1e-27
Identities = 73/263 (27%), Positives = 128/263 (48%), Gaps = 13/263 (4%)
Query: 261 PDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIE 320
P+ L TL GH V ++ F P LAS +AD + +W + +
Sbjct: 29 PNYALKCTLVGHTEAVSSVKFSPNGEW--------LASSSADRLIIIWGAYDGKYEKTLY 80
Query: 321 GHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLA 380
GH + ++ V W L + D++ +LWD+ + + + +GHS V+ F+ +L
Sbjct: 81 GHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLI 140
Query: 381 GTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRR 440
+G D ++W+++TG+C+ L H + ++F+ +G I +GS D C++WD +
Sbjct: 141 ISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQ 200
Query: 441 CVYTIPAHQN-LVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGK---VM 496
C+ T+ N V+ VKF P +G ++LT DNT K+W + LKT GH+ + +
Sbjct: 201 CLKTLVDDDNPPVSFVKFSP-NGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIF 259
Query: 497 GLDISSDGQLIATCSYDRTFKLW 519
+ G+ I + S D +W
Sbjct: 260 ANFSVTGGKWIVSGSEDNLVYIW 282
Score = 30.8 bits (68), Expect = 3.1
Identities = 15/56 (26%), Positives = 30/56 (53%)
Query: 466 LTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMA 521
L+ + + + ++ +P ++ TL GH V + S +G+ +A+ S DR +W A
Sbjct: 15 LSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGA 70
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 135 bits (340), Expect = 9e-32
Identities = 79/299 (26%), Positives = 143/299 (47%), Gaps = 13/299 (4%)
Query: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVS 288
G + +S FSPN + LA++ L K+W D T+ GH + + + S +
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL- 101
Query: 289 LDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWR 348
L S + D ++K+W + S + + ++GH+ V ++P + + +D S R
Sbjct: 102 -------LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154
Query: 349 LWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCI-MFLEGHL 407
+WD++ + + HS V + F++DGSL + D R+WD +G+C+ ++
Sbjct: 155 IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN 214
Query: 408 KEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQN--LVTGVKFEPIHGNFL 465
+ + FSPNG +I + DNT K+WD + +C+ T H+N F G ++
Sbjct: 215 PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWI 274
Query: 466 LTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSY--DRTFKLWMAE 522
++G+ DN IW ++ L GH V+ +IA+ + D+T KLW ++
Sbjct: 275 VSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333
Score = 126 bits (317), Expect = 4e-29
Identities = 74/263 (28%), Positives = 127/263 (48%), Gaps = 13/263 (4%)
Query: 261 PDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIE 320
P+ L TL GH V ++ F P LAS +AD +K+W + I
Sbjct: 33 PNYALKFTLAGHTKAVSSVKFSPNGEW--------LASSSADKLIKIWGAYDGKFEKTIS 84
Query: 321 GHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLA 380
GH + ++ V W L + D++ ++WD+ + + + +GHS V+ F+ +L
Sbjct: 85 GHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLI 144
Query: 381 GTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRR 440
+G D R+WD++TG+C+ L H + ++F+ +G I + S D C++WD +
Sbjct: 145 VSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ 204
Query: 441 CVYTIPAHQN-LVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGK---VM 496
C+ T+ N V+ VKF P +G ++L DNT K+W + LKT GH+ + +
Sbjct: 205 CLKTLIDDDNPPVSFVKFSP-NGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIF 263
Query: 497 GLDISSDGQLIATCSYDRTFKLW 519
+ G+ I + S D +W
Sbjct: 264 ANFSVTGGKWIVSGSEDNLVYIW 286
Score = 32.3 bits (72), Expect = 1.1
Identities = 15/42 (35%), Positives = 24/42 (57%)
Query: 480 PGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMA 521
P ++ TLAGH V + S +G+ +A+ S D+ K+W A
Sbjct: 33 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA 74
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 135 bits (340), Expect = 9e-32
Identities = 79/299 (26%), Positives = 143/299 (47%), Gaps = 13/299 (4%)
Query: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVS 288
G + +S FSPN + LA++ L K+W D T+ GH + + + S +
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL- 101
Query: 289 LDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWR 348
L S + D ++K+W + S + + ++GH+ V ++P + + +D S R
Sbjct: 102 -------LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154
Query: 349 LWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCI-MFLEGHL 407
+WD++ + + HS V + F++DGSL + D R+WD +G+C+ ++
Sbjct: 155 IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN 214
Query: 408 KEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQN--LVTGVKFEPIHGNFL 465
+ + FSPNG +I + DNT K+WD + +C+ T H+N F G ++
Sbjct: 215 PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWI 274
Query: 466 LTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSY--DRTFKLWMAE 522
++G+ DN IW ++ L GH V+ +IA+ + D+T KLW ++
Sbjct: 275 VSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333
Score = 126 bits (317), Expect = 4e-29
Identities = 74/263 (28%), Positives = 127/263 (48%), Gaps = 13/263 (4%)
Query: 261 PDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIE 320
P+ L TL GH V ++ F P LAS +AD +K+W + I
Sbjct: 33 PNYALKFTLAGHTKAVSSVKFSPNGEW--------LASSSADKLIKIWGAYDGKFEKTIS 84
Query: 321 GHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLA 380
GH + ++ V W L + D++ ++WD+ + + + +GHS V+ F+ +L
Sbjct: 85 GHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLI 144
Query: 381 GTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRR 440
+G D R+WD++TG+C+ L H + ++F+ +G I + S D C++WD +
Sbjct: 145 VSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ 204
Query: 441 CVYTIPAHQN-LVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGK---VM 496
C+ T+ N V+ VKF P +G ++L DNT K+W + LKT GH+ + +
Sbjct: 205 CLKTLIDDDNPPVSFVKFSP-NGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIF 263
Query: 497 GLDISSDGQLIATCSYDRTFKLW 519
+ G+ I + S D +W
Sbjct: 264 ANFSVTGGKWIVSGSEDNLVYIW 286
Score = 32.3 bits (72), Expect = 1.1
Identities = 15/42 (35%), Positives = 24/42 (57%)
Query: 480 PGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMA 521
P ++ TLAGH V + S +G+ +A+ S D+ K+W A
Sbjct: 33 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA 74
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 131 bits (330), Expect = 1e-30
Identities = 85/291 (29%), Positives = 127/291 (43%), Gaps = 9/291 (3%)
Query: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVS 288
G I+ SPN K LATA W LW+ + GH V ++ F P +
Sbjct: 16 GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNL- 74
Query: 289 LDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWR 348
LAS + D +V+LW D ++ + HT V V + G+FL T D+S +
Sbjct: 75 -------LASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIK 127
Query: 349 LWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLK 408
+W + Q + H+ V F DG L + D ++WD +C+ +
Sbjct: 128 VWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVG 187
Query: 409 EIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTG 468
++F+P+G IA+ D T KVWD+R + + H V + F P GN+L+T
Sbjct: 188 FANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHP-SGNYLITA 246
Query: 469 AYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
+ D T KI + TL GH G V + S G+L A+ D LW
Sbjct: 247 SSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
Score = 90.5 bits (223), Expect = 3e-18
Identities = 53/210 (25%), Positives = 94/210 (44%), Gaps = 3/210 (1%)
Query: 312 SDEPVAD--IEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVY 369
+++PV + +GH + + P+G+ L T +D LW+ + GH V
Sbjct: 5 TEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVT 64
Query: 370 DIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDN 429
+ F G+L + D R+W + H + ++FS +G +AT S D
Sbjct: 65 SVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDK 124
Query: 430 TCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLA 489
+ KVW + ++R +Y++ H + V KF P G +++ + D T KIW + +
Sbjct: 125 SIKVWSMYRQRFLYSLYRHTHWVRCAKFSP-DGRLIVSCSEDKTIKIWDTTNKQCVNNFS 183
Query: 490 GHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
G +D + G IA+ D+T K+W
Sbjct: 184 DSVGFANFVDFNPSGTCIASAGSDQTVKVW 213
Score = 42.4 bits (98), Expect = 0.001
Identities = 21/75 (28%), Positives = 36/75 (48%), Gaps = 1/75 (1%)
Query: 448 HQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLI 507
H+ +T + P +G L T ++D +W + GH+ V + S G L+
Sbjct: 17 HKAAITSLDLSP-NGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLL 75
Query: 508 ATCSYDRTFKLWMAE 522
A+ S DRT +LW+ +
Sbjct: 76 ASASRDRTVRLWIPD 90
Score = 36.2 bits (82), Expect = 0.075
Identities = 25/76 (32%), Positives = 33/76 (43%), Gaps = 8/76 (10%)
Query: 239 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLAS 298
F P+ L TA G K+ + + L++TL+GH P TVS AS
Sbjct: 236 FHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTG--------PVFTVSFSKGGELFAS 287
Query: 299 CAADGSVKLWSLDSDE 314
AD V LW + DE
Sbjct: 288 GGADTQVLLWRTNFDE 303
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 130 bits (328), Expect = 2e-30
Identities = 86/311 (27%), Positives = 137/311 (44%), Gaps = 29/311 (9%)
Query: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVS 288
G P++ F P ++ +A K+W + TL+GH +V +S
Sbjct: 106 GHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSV--------QDIS 157
Query: 289 LDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWR 348
D LASC+AD ++KLW E + + GH V+ V P+G + + D++ +
Sbjct: 158 FDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIK 217
Query: 349 LWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLK 408
+W+++ + GH V + +QDG+L + D RVW + T C L H
Sbjct: 218 MWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEH 277
Query: 409 EIYGINFSPN--------------------GYHIATGSGDNTCKVWDLRQRRCVYTIPAH 448
+ I+++P G + +GS D T K+WD+ C+ T+ H
Sbjct: 278 VVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGH 337
Query: 449 QNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIA 508
N V GV F G F+L+ A D T ++W + +KTL HE V LD +
Sbjct: 338 DNWVRGVLFHS-GGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVV 396
Query: 509 TCSYDRTFKLW 519
T S D+T K+W
Sbjct: 397 TGSVDQTVKVW 407
Score = 126 bits (316), Expect = 6e-29
Identities = 72/272 (26%), Positives = 129/272 (47%), Gaps = 27/272 (9%)
Query: 267 HTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRV 326
+ L GH + V ++FHP +V + S + D ++K+W ++ + ++GHT V
Sbjct: 102 YALSGHRSPVTRVIFHPVFSV--------MVSASEDATIKVWDYETGDFERTLKGHTDSV 153
Query: 327 ARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLD 386
+ + SG+ L + D + +LWD + E I GH V +A +G + D
Sbjct: 154 QDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRD 213
Query: 387 AFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIP 446
++W+++TG C+ GH + + + + +G IA+ S D T +VW + + C +
Sbjct: 214 KTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELR 273
Query: 447 AHQNLVTGVKFEPIH-------------------GNFLLTGAYDNTAKIWTHPGWSPLKT 487
H+++V + + P G FLL+G+ D T K+W L T
Sbjct: 274 EHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMT 333
Query: 488 LAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
L GH+ V G+ S G+ I +C+ D+T ++W
Sbjct: 334 LVGHDNWVRGVLFHSGGKFILSCADDKTLRVW 365
Score = 93.6 bits (231), Expect = 4e-19
Identities = 52/158 (32%), Positives = 83/158 (52%), Gaps = 1/158 (0%)
Query: 363 GHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHI 422
GH V + FH S+ + DA +VWD TG L+GH + I+F +G +
Sbjct: 106 GHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLL 165
Query: 423 ATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGW 482
A+ S D T K+WD + C+ T+ H + V+ V P +G+ +++ + D T K+W
Sbjct: 166 ASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMP-NGDHIVSASRDKTIKMWEVQTG 224
Query: 483 SPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWM 520
+KT GH V + + DG LIA+CS D+T ++W+
Sbjct: 225 YCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWV 262
Score = 83.6 bits (205), Expect = 4e-16
Identities = 57/229 (24%), Positives = 93/229 (40%), Gaps = 28/229 (12%)
Query: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVS 288
G D +S PN + +A K+W V + T GH V + + T+
Sbjct: 190 GHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTL- 248
Query: 289 LDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPS-------------- 334
+ASC+ D +V++W + + E A++ H V + W P
Sbjct: 249 -------IASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSET 301
Query: 335 ------GRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAF 388
G FL + D++ ++WD+ ++ GH V + FH G + D
Sbjct: 302 KKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKT 361
Query: 389 GRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLR 437
RVWD + RC+ L H + ++F ++ TGS D T KVW+ R
Sbjct: 362 LRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 122 bits (307), Expect = 6e-28
Identities = 85/293 (29%), Positives = 137/293 (46%), Gaps = 26/293 (8%)
Query: 230 DDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSL 289
DD I+ F N + + K+WS L TL GH V S
Sbjct: 262 DDHVITCLQFCGNR--IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVW----------SS 309
Query: 290 DPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRL 349
+D + S + D ++K+W+ ++ E + + GHT V + H G+ D + R+
Sbjct: 310 QMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSR--DATLRV 367
Query: 350 WDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKE 409
WD+E + + GH V + + DG +G D +VWD T C+ L+GH
Sbjct: 368 WDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNR 425
Query: 410 IYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGA 469
+Y + F +G H+ +GS D + +VWD+ C++T+ HQ+L +G++ + N L++G
Sbjct: 426 VYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGME---LKDNILVSGN 480
Query: 470 YDNTAKIWTHPGWSPLKTLAG---HEGKVMGLDISSDGQLIATCSYDRTFKLW 519
D+T KIW L+TL G H+ V L + + + T S D T KLW
Sbjct: 481 ADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLW 531
Score = 78.2 bits (191), Expect = 2e-14
Identities = 48/179 (26%), Positives = 86/179 (48%), Gaps = 9/179 (5%)
Query: 344 DRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFL 403
D + ++W + + GH+ GV+ + ++G+ D +VW+ TG CI L
Sbjct: 282 DNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGS--TDRTLKVWNAETGECIHTL 339
Query: 404 EGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGN 463
GH + ++ + +GS D T +VWD+ +C++ + H V V+++ G
Sbjct: 340 YGHTSTVRCMHLHEK--RVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD---GR 394
Query: 464 FLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE 522
+++GAYD K+W + L TL GH +V L DG + + S D + ++W E
Sbjct: 395 RVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVE 451
Score = 76.6 bits (187), Expect = 5e-14
Identities = 62/239 (25%), Positives = 96/239 (40%), Gaps = 61/239 (25%)
Query: 256 KLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEP 315
K+W+ +HTL GH + V + H K VS + D ++++W +++ +
Sbjct: 326 KVWNAETGECIHTLYGHTSTVRCMHLHEKRVVS----------GSRDATLRVWDIETGQC 375
Query: 316 VADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQ 375
+ + GH V V + GR + + YD ++WD E + + +GH+ VY + F
Sbjct: 376 LHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF-- 431
Query: 376 DGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFS------------------- 416
DG +G LD RVWD+ TG CI L GH G+
Sbjct: 432 DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIK 491
Query: 417 ----------PNGYHIA------------TGSGDNTCKVWDLRQRRCVYTIPAHQNLVT 453
PN + A T S D T K+WDL+ + +NLVT
Sbjct: 492 TGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFI------RNLVT 544
Score = 54.7 bits (130), Expect = 2e-07
Identities = 31/104 (29%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 419 GYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWT 478
G I +GS DNT KVW +C+ T+ H GV + N +++G+ D T K+W
Sbjct: 273 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTG---GVWSSQMRDNIIISGSTDRTLKVWN 329
Query: 479 HPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE 522
+ TL GH V + + + + + S D T ++W E
Sbjct: 330 AETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIE 371
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 122 bits (307), Expect = 6e-28
Identities = 85/293 (29%), Positives = 137/293 (46%), Gaps = 26/293 (8%)
Query: 230 DDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSL 289
DD I+ F N + + K+WS L TL GH V S
Sbjct: 380 DDHVITCLQFCGNR--IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVW----------SS 427
Query: 290 DPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRL 349
+D + S + D ++K+W+ ++ E + + GHT V + H G+ D + R+
Sbjct: 428 QMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSR--DATLRV 485
Query: 350 WDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKE 409
WD+E + + GH V + + DG +G D +VWD T C+ L+GH
Sbjct: 486 WDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNR 543
Query: 410 IYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGA 469
+Y + F +G H+ +GS D + +VWD+ C++T+ HQ+L +G++ + N L++G
Sbjct: 544 VYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGME---LKDNILVSGN 598
Query: 470 YDNTAKIWTHPGWSPLKTLAG---HEGKVMGLDISSDGQLIATCSYDRTFKLW 519
D+T KIW L+TL G H+ V L + + + T S D T KLW
Sbjct: 599 ADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLW 649
Score = 78.2 bits (191), Expect = 2e-14
Identities = 48/179 (26%), Positives = 86/179 (48%), Gaps = 9/179 (5%)
Query: 344 DRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFL 403
D + ++W + + GH+ GV+ + ++G+ D +VW+ TG CI L
Sbjct: 400 DNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGS--TDRTLKVWNAETGECIHTL 457
Query: 404 EGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGN 463
GH + ++ + +GS D T +VWD+ +C++ + H V V+++ G
Sbjct: 458 YGHTSTVRCMHLHEK--RVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD---GR 512
Query: 464 FLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE 522
+++GAYD K+W + L TL GH +V L DG + + S D + ++W E
Sbjct: 513 RVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVE 569
Score = 76.6 bits (187), Expect = 5e-14
Identities = 62/239 (25%), Positives = 96/239 (40%), Gaps = 61/239 (25%)
Query: 256 KLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEP 315
K+W+ +HTL GH + V + H K VS + D ++++W +++ +
Sbjct: 444 KVWNAETGECIHTLYGHTSTVRCMHLHEKRVVS----------GSRDATLRVWDIETGQC 493
Query: 316 VADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQ 375
+ + GH V V + GR + + YD ++WD E + + +GH+ VY + F
Sbjct: 494 LHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF-- 549
Query: 376 DGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFS------------------- 416
DG +G LD RVWD+ TG CI L GH G+
Sbjct: 550 DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIK 609
Query: 417 ----------PNGYHIA------------TGSGDNTCKVWDLRQRRCVYTIPAHQNLVT 453
PN + A T S D T K+WDL+ + +NLVT
Sbjct: 610 TGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFI------RNLVT 662
Score = 54.7 bits (130), Expect = 2e-07
Identities = 31/104 (29%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 419 GYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWT 478
G I +GS DNT KVW +C+ T+ H GV + N +++G+ D T K+W
Sbjct: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTG---GVWSSQMRDNIIISGSTDRTLKVWN 447
Query: 479 HPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE 522
+ TL GH V + + + + + S D T ++W E
Sbjct: 448 AETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIE 489
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 122 bits (307), Expect = 6e-28
Identities = 85/293 (29%), Positives = 137/293 (46%), Gaps = 26/293 (8%)
Query: 230 DDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSL 289
DD I+ F N + + K+WS L TL GH V S
Sbjct: 300 DDHVITCLQFCGNR--IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVW----------SS 347
Query: 290 DPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRL 349
+D + S + D ++K+W+ ++ E + + GHT V + H G+ D + R+
Sbjct: 348 QMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSR--DATLRV 405
Query: 350 WDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKE 409
WD+E + + GH V + + DG +G D +VWD T C+ L+GH
Sbjct: 406 WDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNR 463
Query: 410 IYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGA 469
+Y + F +G H+ +GS D + +VWD+ C++T+ HQ+L +G++ + N L++G
Sbjct: 464 VYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGME---LKDNILVSGN 518
Query: 470 YDNTAKIWTHPGWSPLKTLAG---HEGKVMGLDISSDGQLIATCSYDRTFKLW 519
D+T KIW L+TL G H+ V L + + + T S D T KLW
Sbjct: 519 ADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLW 569
Score = 78.2 bits (191), Expect = 2e-14
Identities = 48/179 (26%), Positives = 86/179 (48%), Gaps = 9/179 (5%)
Query: 344 DRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFL 403
D + ++W + + GH+ GV+ + ++G+ D +VW+ TG CI L
Sbjct: 320 DNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGS--TDRTLKVWNAETGECIHTL 377
Query: 404 EGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGN 463
GH + ++ + +GS D T +VWD+ +C++ + H V V+++ G
Sbjct: 378 YGHTSTVRCMHLHEK--RVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD---GR 432
Query: 464 FLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE 522
+++GAYD K+W + L TL GH +V L DG + + S D + ++W E
Sbjct: 433 RVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVE 489
Score = 76.6 bits (187), Expect = 5e-14
Identities = 62/239 (25%), Positives = 96/239 (40%), Gaps = 61/239 (25%)
Query: 256 KLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEP 315
K+W+ +HTL GH + V + H K VS + D ++++W +++ +
Sbjct: 364 KVWNAETGECIHTLYGHTSTVRCMHLHEKRVVS----------GSRDATLRVWDIETGQC 413
Query: 316 VADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQ 375
+ + GH V V + GR + + YD ++WD E + + +GH+ VY + F
Sbjct: 414 LHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF-- 469
Query: 376 DGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFS------------------- 416
DG +G LD RVWD+ TG CI L GH G+
Sbjct: 470 DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIK 529
Query: 417 ----------PNGYHIA------------TGSGDNTCKVWDLRQRRCVYTIPAHQNLVT 453
PN + A T S D T K+WDL+ + +NLVT
Sbjct: 530 TGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFI------RNLVT 582
Score = 54.7 bits (130), Expect = 2e-07
Identities = 31/104 (29%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 419 GYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWT 478
G I +GS DNT KVW +C+ T+ H GV + N +++G+ D T K+W
Sbjct: 311 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTG---GVWSSQMRDNIIISGSTDRTLKVWN 367
Query: 479 HPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE 522
+ TL GH V + + + + + S D T ++W E
Sbjct: 368 AETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIE 409
>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
[Homo sapiens]
Length = 340
Score = 121 bits (303), Expect = 2e-27
Identities = 79/291 (27%), Positives = 134/291 (46%), Gaps = 22/291 (7%)
Query: 238 HFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLA 297
H+ +S++L +A G +W N +H + ++ V + P N
Sbjct: 62 HWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSG---------NYV 112
Query: 298 SCAA-DGSVKLWSLDSDEPVA----DIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDL 352
+C D +++L + E ++ GHT ++ + + + T+ D + LWD+
Sbjct: 113 ACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIV-TSSGDTTCALWDI 171
Query: 353 EAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYG 412
E ++ GHS V ++ D +G DA ++WD+R G C GH+ +I
Sbjct: 172 ETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINA 231
Query: 413 INFSPNGYHIATGSGDNTCKVWDLR--QRRCVYTIPAHQNLVTGVKFEPI--HGNFLLTG 468
++F PNGY ATGS D TC+++DLR Q +Y +H N++ G+ G LL G
Sbjct: 232 VSFFPNGYAFATGSDDATCRLFDLRADQELLLY---SHDNIICGITSVAFSKSGRLLLAG 288
Query: 469 AYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
D +W LAGH+ +V L ++ DG +AT S+D ++W
Sbjct: 289 YDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIW 339
Score = 82.0 bits (201), Expect = 1e-15
Identities = 57/204 (27%), Positives = 90/204 (44%), Gaps = 11/204 (5%)
Query: 234 ISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKD 293
+S C F +S+++ T+ C LW + T GH+ +V ++SL P
Sbjct: 146 LSCCRFLDDSQIV-TSSGDTTCALWDIETAQQTTTFTGHSGDV--------MSLSLSPDM 196
Query: 294 VNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLE 353
S A D S KLW + GH + V + P+G T D + RL+DL
Sbjct: 197 RTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLR 256
Query: 354 AQEEILHQEGHSM--GVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIY 411
A +E+L ++ G+ +AF + G L G D VWD G L GH +
Sbjct: 257 ADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVS 316
Query: 412 GINFSPNGYHIATGSGDNTCKVWD 435
+ + +G +ATGS D+ ++W+
Sbjct: 317 CLGVTDDGMAVATGSWDSFLRIWN 340
Score = 70.1 bits (170), Expect = 5e-12
Identities = 51/205 (24%), Positives = 83/205 (40%), Gaps = 6/205 (2%)
Query: 319 IEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGS 378
+ GH ++ + W R L + D +WD ++ S V A+ G+
Sbjct: 51 LRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGN 110
Query: 379 LAGTGGLDAFGRVWDLRTG----RCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVW 434
GGLD +++L+T R L GH + F + I T SGD TC +W
Sbjct: 111 YVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDS-QIVTSSGDTTCALW 169
Query: 435 DLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGK 494
D+ + T H V + P F ++GA D ++K+W ++ GH
Sbjct: 170 DIETAQQTTTFTGHSGDVMSLSLSPDMRTF-VSGACDASSKLWDIRDGMCRQSFTGHVSD 228
Query: 495 VMGLDISSDGQLIATCSYDRTFKLW 519
+ + +G AT S D T +L+
Sbjct: 229 INAVSFFPNGYAFATGSDDATCRLF 253
Score = 55.1 bits (131), Expect = 2e-07
Identities = 43/184 (23%), Positives = 74/184 (40%), Gaps = 52/184 (28%)
Query: 382 TGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGIN--------------------------- 414
T +D+ GR+ +RT R L GHL +IY ++
Sbjct: 34 TSNMDSVGRI-QMRTRRT---LRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNK 89
Query: 415 ---------------FSPNGYHIATGSGDNTCKVWDLRQR----RCVYTIPAHQNLVTGV 455
++P+G ++A G DN C +++L+ R R +P H ++
Sbjct: 90 MHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCC 149
Query: 456 KFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRT 515
+F + + ++T + D T +W T GH G VM L +S D + + + D +
Sbjct: 150 RF--LDDSQIVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDAS 207
Query: 516 FKLW 519
KLW
Sbjct: 208 SKLW 211
>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
[Homo sapiens]
Length = 340
Score = 119 bits (299), Expect = 5e-27
Identities = 81/291 (27%), Positives = 132/291 (45%), Gaps = 22/291 (7%)
Query: 238 HFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLA 297
H+ +S++L +A G +W N +H + ++ V + P N
Sbjct: 62 HWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG---------NFV 112
Query: 298 SCAA-DGSVKLWSLDSDEPVA----DIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDL 352
+C D ++SL + E ++ GHT ++ + + + T+ D + LWD+
Sbjct: 113 ACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQII-TSSGDTTCALWDI 171
Query: 353 EAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYG 412
E ++ + GHS V ++ DG +G DA ++WD+R C GH +I
Sbjct: 172 ETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINA 231
Query: 413 INFSPNGYHIATGSGDNTCKVWDLR--QRRCVYTIPAHQNLVTGVKFEPI--HGNFLLTG 468
+ F PNGY TGS D TC+++DLR Q +Y +H N++ G+ G LL G
Sbjct: 232 VAFFPNGYAFTTGSDDATCRLFDLRADQELLMY---SHDNIICGITSVAFSRSGRLLLAG 288
Query: 469 AYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
D IW LAGH+ +V L ++ DG +AT S+D K+W
Sbjct: 289 YDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339
Score = 78.2 bits (191), Expect = 2e-14
Identities = 55/204 (26%), Positives = 90/204 (44%), Gaps = 11/204 (5%)
Query: 234 ISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKD 293
+S C F +++++ T+ C LW + GH+ +V ++SL P
Sbjct: 146 LSCCRFLDDNQII-TSSGDTTCALWDIETGQQTVGFAGHSGDV--------MSLSLAPDG 196
Query: 294 VNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLE 353
S A D S+KLW + GH + V + P+G T D + RL+DL
Sbjct: 197 RTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLR 256
Query: 354 AQEEILHQEGHSM--GVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIY 411
A +E+L ++ G+ +AF + G L G D +WD G L GH +
Sbjct: 257 ADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVS 316
Query: 412 GINFSPNGYHIATGSGDNTCKVWD 435
+ + +G +ATGS D+ K+W+
Sbjct: 317 CLGVTDDGMAVATGSWDSFLKIWN 340
Score = 70.1 bits (170), Expect = 5e-12
Identities = 51/205 (24%), Positives = 80/205 (39%), Gaps = 6/205 (2%)
Query: 319 IEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGS 378
+ GH ++ + W R L + D +WD ++ S V A+ G+
Sbjct: 51 LRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGN 110
Query: 379 LAGTGGLDAFGRVWDLRTG----RCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVW 434
GGLD ++ L+T R L GH + F + I T SGD TC +W
Sbjct: 111 FVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDN-QIITSSGDTTCALW 169
Query: 435 DLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGK 494
D+ + H V + P G ++GA D + K+W +T GHE
Sbjct: 170 DIETGQQTVGFAGHSGDVMSLSLAP-DGRTFVSGACDASIKLWDVRDSMCRQTFIGHESD 228
Query: 495 VMGLDISSDGQLIATCSYDRTFKLW 519
+ + +G T S D T +L+
Sbjct: 229 INAVAFFPNGYAFTTGSDDATCRLF 253
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
[Homo sapiens]
Length = 340
Score = 117 bits (293), Expect = 3e-26
Identities = 79/289 (27%), Positives = 132/289 (45%), Gaps = 18/289 (6%)
Query: 238 HFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLA 297
H+ +S++L +A G +W N +H + ++ V + P N
Sbjct: 62 HWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG---------NYV 112
Query: 298 SCAA-DGSVKLWSLDSDEPVA----DIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDL 352
+C D +++L + E ++ GHT ++ + + + T+ D + LWD+
Sbjct: 113 ACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIV-TSSGDTTCALWDI 171
Query: 353 EAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYG 412
E ++ GH+ V ++ D L +G DA ++WD+R G C GH +I
Sbjct: 172 ETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINA 231
Query: 413 INFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPI--HGNFLLTGAY 470
I F PNG ATGS D TC+++DLR + + T +H N++ G+ G LL G
Sbjct: 232 ICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIICGITSVSFSKSGRLLLAGYD 290
Query: 471 DNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
D +W LAGH+ +V L ++ DG +AT S+D K+W
Sbjct: 291 DFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339
Score = 75.5 bits (184), Expect = 1e-13
Identities = 53/204 (25%), Positives = 88/204 (43%), Gaps = 11/204 (5%)
Query: 234 ISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKD 293
+S C F +++++ T+ C LW + T GH +V ++SL P
Sbjct: 146 LSCCRFLDDNQIV-TSSGDTTCALWDIETGQQTTTFTGHTGDV--------MSLSLAPDT 196
Query: 294 VNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLE 353
S A D S KLW + GH + + + P+G T D + RL+DL
Sbjct: 197 RLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLR 256
Query: 354 AQEEILHQEGHSM--GVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIY 411
A +E++ ++ G+ ++F + G L G D VWD L GH +
Sbjct: 257 ADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVS 316
Query: 412 GINFSPNGYHIATGSGDNTCKVWD 435
+ + +G +ATGS D+ K+W+
Sbjct: 317 CLGVTDDGMAVATGSWDSFLKIWN 340
Score = 74.3 bits (181), Expect = 2e-13
Identities = 53/205 (25%), Positives = 83/205 (40%), Gaps = 6/205 (2%)
Query: 319 IEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGS 378
+ GH ++ + W R L + D +WD ++ S V A+ G+
Sbjct: 51 LRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGN 110
Query: 379 LAGTGGLDAFGRVWDLRTG----RCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVW 434
GGLD +++L+T R L GH + F + I T SGD TC +W
Sbjct: 111 YVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDN-QIVTSSGDTTCALW 169
Query: 435 DLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGK 494
D+ + T H V + P ++GA D +AK+W +T GHE
Sbjct: 170 DIETGQQTTTFTGHTGDVMSLSLAP-DTRLFVSGACDASAKLWDVREGMCRQTFTGHESD 228
Query: 495 VMGLDISSDGQLIATCSYDRTFKLW 519
+ + +G AT S D T +L+
Sbjct: 229 INAICFFPNGNAFATGSDDATCRLF 253
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 115 bits (288), Expect = 1e-25
Identities = 75/269 (27%), Positives = 124/269 (46%), Gaps = 17/269 (6%)
Query: 242 NSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAA 301
+ ++LAT LWS+ N + +L GH + P +V L+ + + + +
Sbjct: 32 SGRLLATGGDDCRVNLWSINKPNCIMSLTGHTS--------PVESVRLNTPEELIVAGSQ 83
Query: 302 DGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQ 361
GS+++W L++ + + + GH + + +HP G F+ + D + +LWD+ + +
Sbjct: 84 SGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRY 143
Query: 362 EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYH 421
GHS V + F DG + D ++WDL G+ + GH + + F PN Y
Sbjct: 144 RGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYL 203
Query: 422 IATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPG 481
+A+GS D T + WDL + + V I V V F P G L +G D+ G
Sbjct: 204 LASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNP-DGCCLYSGCQDSLRVY----G 258
Query: 482 WSP---LKTLAGHEGKVMGLDISSDGQLI 507
W P + + GKV L I +D QLI
Sbjct: 259 WEPERCFDVVLVNWGKVADLAICND-QLI 286
Score = 107 bits (267), Expect = 3e-23
Identities = 63/206 (30%), Positives = 95/206 (46%), Gaps = 2/206 (0%)
Query: 318 DIEGHTVRVAR-VMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQD 376
+I H V+ V+ SGR L T D LW + I+ GH+ V + +
Sbjct: 15 EIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTP 74
Query: 377 GSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDL 436
L G RVWDL + + L GH I ++F P G +A+GS D K+WD+
Sbjct: 75 EELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDI 134
Query: 437 RQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVM 496
R++ CV+ H V ++F P G +L + A D+T K+W + GH G V
Sbjct: 135 RRKGCVFRYRGHSQAVRCLRFSP-DGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVN 193
Query: 497 GLDISSDGQLIATCSYDRTFKLWMAE 522
++ + L+A+ S DRT + W E
Sbjct: 194 VVEFHPNEYLLASGSSDRTIRFWDLE 219
Score = 96.3 bits (238), Expect = 6e-20
Identities = 58/225 (25%), Positives = 102/225 (45%), Gaps = 9/225 (4%)
Query: 217 SLRSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNV 276
S+ N S G P+ + +++ SG ++W + +L TL GH N+
Sbjct: 49 SINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANI 108
Query: 277 GAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGR 336
++ FHP +AS + D ++KLW + V GH+ V + + P G+
Sbjct: 109 CSLDFHPYGEF--------VASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGK 160
Query: 337 FLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRT 396
+L + D + +LWDL A + + GH+ V + FH + L +G D R WDL
Sbjct: 161 WLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEK 220
Query: 397 GRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRC 441
+ + +EG + + F+P+G + +G D + +V+ RC
Sbjct: 221 FQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYGWEPERC 264
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 115 bits (288), Expect = 1e-25
Identities = 77/287 (26%), Positives = 122/287 (42%), Gaps = 10/287 (3%)
Query: 233 PISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPK 292
P+S P+ +L + L K+ +P CN+L T GH + FHP
Sbjct: 354 PVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGD------ 407
Query: 293 DVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDL 352
LA+ + D +VKLW L + + EGH+ V WH G F+ ++ D++ ++WD+
Sbjct: 408 --KLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDV 465
Query: 353 EAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYG 412
++ GH+ V I F + T D +WD RTG C L GH+ I
Sbjct: 466 NSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSIND 525
Query: 413 INFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDN 472
F P G+ IA+ K+WD R+ + +I + V F+ +L A N
Sbjct: 526 AIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFD--SSGRVLAQASGN 583
Query: 473 TAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
+ L GHE + + S DG+++ + D T + W
Sbjct: 584 GVIHLLDLKSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
Score = 101 bits (251), Expect = 2e-21
Identities = 60/198 (30%), Positives = 89/198 (44%), Gaps = 1/198 (0%)
Query: 322 HTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAG 381
H + V+ V P L + DR W++ L +L GH+ + D FH G
Sbjct: 351 HELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLA 410
Query: 382 TGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRC 441
T D ++WDL G CI+ EGH + ++ + G +A+ S D T K+WD+ RC
Sbjct: 411 TSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERC 470
Query: 442 VYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDIS 501
T+ H + V ++F P N LLT + D T IW ++L GH +
Sbjct: 471 RCTLYGHTDSVNSIEFFPF-SNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFD 529
Query: 502 SDGQLIATCSYDRTFKLW 519
G +IA+C KLW
Sbjct: 530 PRGHMIASCDACGVTKLW 547
Score = 69.7 bits (169), Expect = 6e-12
Identities = 44/158 (27%), Positives = 68/158 (43%), Gaps = 1/158 (0%)
Query: 364 HSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIA 423
H + V ++ + + G D +V L ++ GH + F P+G +A
Sbjct: 351 HELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLA 410
Query: 424 TGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWS 483
T SGD T K+WDL + C+ T H V + GNF+ + + D T+KIW
Sbjct: 411 TSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSC-GNFVASSSLDKTSKIWDVNSER 469
Query: 484 PLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMA 521
TL GH V ++ + T S D+T +W A
Sbjct: 470 CRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDA 507
Score = 57.4 bits (137), Expect = 3e-08
Identities = 48/207 (23%), Positives = 84/207 (40%), Gaps = 11/207 (5%)
Query: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVS 288
G R + C + +A++ K+W V TL GH +V +I F P S
Sbjct: 434 GHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSN-- 491
Query: 289 LDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWR 348
L + +AD ++ +W + + GH + ++ P G + + +
Sbjct: 492 ------TLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTK 545
Query: 349 LWDLEAQEEILHQE-GHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHL 407
LWD I+ + G S G ++ F G + + + DL++G I L GH
Sbjct: 546 LWDFRKLLPIVSIDIGPSPG-NEVNFDSSGRVLAQASGNGVIHLLDLKSGE-IHKLMGHE 603
Query: 408 KEIYGINFSPNGYHIATGSGDNTCKVW 434
E + + FS +G + +G D T + W
Sbjct: 604 NEAHTVVFSHDGEILFSGGSDGTVRTW 630
Score = 55.8 bits (133), Expect = 9e-08
Identities = 44/168 (26%), Positives = 65/168 (38%), Gaps = 9/168 (5%)
Query: 225 CSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPK 284
C+ G ++ F P S L T+ +W +L GH ++ +F
Sbjct: 472 CTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIF--- 528
Query: 285 STVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYD 344
DP+ +ASC A G KLW P+ I+ V + SGR L +
Sbjct: 529 -----DPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGN 583
Query: 345 RSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVW 392
L DL++ EI GH + + F DG + +GG D R W
Sbjct: 584 GVIHLLDLKS-GEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
>gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo
sapiens]
Length = 504
Score = 114 bits (286), Expect = 2e-25
Identities = 68/257 (26%), Positives = 119/257 (46%), Gaps = 12/257 (4%)
Query: 265 LLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTV 324
+L TL+GH V ++VFHP + + S + D ++++WS+ + V + H
Sbjct: 256 ILATLKGHTKKVTSVVFHPSQDL--------VFSASPDATIRIWSVPNASCVQVVRAHES 307
Query: 325 RVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMG--VYDIAFHQDGSLAGT 382
V + H +G +L ++ D+ W D++ + + G + FH DG + GT
Sbjct: 308 AVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGT 367
Query: 383 GGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCV 442
G +D+ ++WDL+ + GH I I FS NGY++AT + D++ K+WDLR+ +
Sbjct: 368 GTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNF 427
Query: 443 YTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISS 502
T+ N G +L G D +I+ W+ + H G G+
Sbjct: 428 KTLQLDNNFEVKSLIFDQSGTYLALGGTD--VQIYICKQWTEILHFTEHSGLTTGVAFGH 485
Query: 503 DGQLIATCSYDRTFKLW 519
+ IA+ DR+ K +
Sbjct: 486 HAKFIASTGMDRSLKFY 502
Score = 86.7 bits (213), Expect = 5e-17
Identities = 84/369 (22%), Positives = 165/369 (44%), Gaps = 28/369 (7%)
Query: 116 GEPITL---FGEGPAERRERLRNILSVVGTDALKKTKKDDEKSKKSKE--EYQQTWYHEG 170
GEP+ L G P E ++L++ +V+ T+ K+ K E+ K +E +Y+Q H G
Sbjct: 157 GEPMDLGELVGMTP-EIIQKLQDKATVLTTERKKRGKTVPEELVKPEELSKYRQVASHVG 215
Query: 171 PNSLKVARLWIANYSLPRAMKRLEEARLHKEIPETTRTSQMQELHKSLRSLNNFCSQIGD 230
+S + + +A P ++ K + ++S+ + L +L G
Sbjct: 216 LHSASIPGI-LALDLCPSDTNKILTGGADKNVVVFDKSSE-----QILATLK------GH 263
Query: 231 DRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLD 290
+ ++ F P+ ++ +A ++WSVP+ + + +R H + V + H L
Sbjct: 264 TKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLS 323
Query: 291 PKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLW 350
D + + + ++ + +DE G ++ A+ +HP G GT D ++W
Sbjct: 324 SSDDQYWAFSDIQTGRVLTKVTDE----TSGCSLTCAQ--FHPDGLIFGTGTMDSQIKIW 377
Query: 351 DLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLE-GHLKE 409
DL+ + + + GHS + IAF ++G T D+ ++WDLR + L+ + E
Sbjct: 378 DLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFE 437
Query: 410 IYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGA 469
+ + F +G ++A G D +++ +Q + H L TGV F H F+ +
Sbjct: 438 VKSLIFDQSGTYLALGGTD--VQIYICKQWTEILHFTEHSGLTTGVAFGH-HAKFIASTG 494
Query: 470 YDNTAKIWT 478
D + K ++
Sbjct: 495 MDRSLKFYS 503
Score = 63.2 bits (152), Expect = 6e-10
Identities = 43/182 (23%), Positives = 72/182 (39%), Gaps = 45/182 (24%)
Query: 382 TGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRC 441
TGG D V+D + + + L+GH K++ + F P+ + + S D T ++W + C
Sbjct: 239 TGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASC 298
Query: 442 VYTIPAHQNLVTGVKFEPIHGNFLL----------------------------------- 466
V + AH++ VTG+ G++LL
Sbjct: 299 VQVVRAHESAVTGLSLHAT-GDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQ 357
Query: 467 ---------TGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFK 517
TG D+ KIW + + GH G + + S +G +AT + D + K
Sbjct: 358 FHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVK 417
Query: 518 LW 519
LW
Sbjct: 418 LW 419
Score = 33.5 bits (75), Expect = 0.49
Identities = 18/61 (29%), Positives = 26/61 (42%)
Query: 459 PIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKL 518
P N +LTG D ++ L TL GH KV + L+ + S D T ++
Sbjct: 231 PSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRI 290
Query: 519 W 519
W
Sbjct: 291 W 291
>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
sapiens]
Length = 340
Score = 112 bits (279), Expect = 1e-24
Identities = 80/295 (27%), Positives = 136/295 (46%), Gaps = 30/295 (10%)
Query: 238 HFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLA 297
H++ +SK+L +A G +W N +H + ++ V + P N
Sbjct: 62 HWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSG---------NFV 112
Query: 298 SCAA-DGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSG-----RFLG-----TTCYDRS 346
+C D +++L S E V+V+R + +G RFL T+ D +
Sbjct: 113 ACGGLDNMCSIYNLKSREG-------NVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTT 165
Query: 347 WRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGH 406
LWD+E ++ GH+ +A D +L +G DA ++WD+R G C GH
Sbjct: 166 CALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGH 225
Query: 407 LKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFE--PIHGNF 464
+I I F PNG I TGS D +C+++DLR + + +H++++ G+ + G
Sbjct: 226 ESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICF-SHESIICGITSVAFSLSGRL 284
Query: 465 LLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
L G D +W + L+GH+ +V L +++DG +AT S+D K+W
Sbjct: 285 LFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIW 339
Score = 75.5 bits (184), Expect = 1e-13
Identities = 55/205 (26%), Positives = 86/205 (41%), Gaps = 13/205 (6%)
Query: 234 ISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKD 293
+S C F ++ ++ T+ C LW + GH + ++ P D
Sbjct: 146 LSCCRFLDDNNIV-TSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSP---------D 195
Query: 294 VNL-ASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDL 352
NL S A D S KLW + GH + + + P+G + T D S RL+DL
Sbjct: 196 FNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDL 255
Query: 353 EAQEEIL--HQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEI 410
A +E++ E G+ +AF G L G D VWD + L GH +
Sbjct: 256 RADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRV 315
Query: 411 YGINFSPNGYHIATGSGDNTCKVWD 435
+ + +G +ATGS D+ K+W+
Sbjct: 316 SCLGVTADGMAVATGSWDSFLKIWN 340
Score = 65.9 bits (159), Expect = 9e-11
Identities = 47/205 (22%), Positives = 84/205 (40%), Gaps = 6/205 (2%)
Query: 319 IEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGS 378
+ GH ++ + W + L + D +WD ++ S V A+ G+
Sbjct: 51 LRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGN 110
Query: 379 LAGTGGLDAFGRVWDLRTG----RCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVW 434
GGLD +++L++ + L H + F + +I T SGD TC +W
Sbjct: 111 FVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDN-NIVTSSGDTTCALW 169
Query: 435 DLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGK 494
D+ + H + P N ++GA D +AK+W + +T GHE
Sbjct: 170 DIETGQQKTVFVGHTGDCMSLAVSP-DFNLFISGACDASAKLWDVREGTCRQTFTGHESD 228
Query: 495 VMGLDISSDGQLIATCSYDRTFKLW 519
+ + +G+ I T S D + +L+
Sbjct: 229 INAICFFPNGEAICTGSDDASCRLF 253
Score = 52.8 bits (125), Expect = 8e-07
Identities = 42/143 (29%), Positives = 62/143 (43%), Gaps = 10/143 (6%)
Query: 384 GLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVY 443
GL+ GRV +RT R L GHL +IY ++++ + + + S D VWD V+
Sbjct: 36 GLEVVGRV-QMRTRRT---LRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVH 91
Query: 444 TIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWT----HPGWSPLKTLAGHEGKVMGLD 499
IP + V + P GNF+ G DN I+ + L+ H G +
Sbjct: 92 AIPLRSSWVMTCAYAP-SGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCR 150
Query: 500 ISSDGQLIATCSYDRTFKLWMAE 522
D ++ T S D T LW E
Sbjct: 151 FLDDNNIV-TSSGDTTCALWDIE 172
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 112 bits (279), Expect = 1e-24
Identities = 63/201 (31%), Positives = 97/201 (48%), Gaps = 1/201 (0%)
Query: 321 GHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLA 380
GH+ V + P +L ++ D + RLW L+ ++ +GH+ V+D F G
Sbjct: 541 GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYF 600
Query: 381 GTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRR 440
+GG D R+W + + GHL ++ F PN ++ATGS D T ++WD+
Sbjct: 601 VSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGN 660
Query: 441 CVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDI 500
CV H+ + + F P +G FL TGA D +W + L GH V L
Sbjct: 661 CVRIFTGHKGPIHSLTFSP-NGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRF 719
Query: 501 SSDGQLIATCSYDRTFKLWMA 521
S DG+++A+ S D T +LW A
Sbjct: 720 SRDGEILASGSMDNTVRLWDA 740
Score = 110 bits (275), Expect = 3e-24
Identities = 60/195 (30%), Positives = 92/195 (47%), Gaps = 1/195 (0%)
Query: 283 PKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTC 342
P S P L S + DG+V+LWSL + + +GH V + P G + +
Sbjct: 545 PVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGG 604
Query: 343 YDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMF 402
+DR RLW + + + GH V FH + + TG D R+WD+ G C+
Sbjct: 605 HDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRI 664
Query: 403 LEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHG 462
GH I+ + FSPNG +ATG+ D +WD+ V + H + V ++F G
Sbjct: 665 FTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSR-DG 723
Query: 463 NFLLTGAYDNTAKIW 477
L +G+ DNT ++W
Sbjct: 724 EILASGSMDNTVRLW 738
Score = 102 bits (254), Expect = 9e-22
Identities = 67/259 (25%), Positives = 110/259 (42%), Gaps = 15/259 (5%)
Query: 178 RLWIANYSLPRAMKRLEEARL-HKEIPETTRTSQMQELHKSLRSLNNFCSQIGDDRPISY 236
R+W R++K+ + L KE + ++ L+ L G P+
Sbjct: 495 RVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKIL------YGHSGPVYG 548
Query: 237 CHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNL 296
FSP+ L ++ G +LWS+ L +GHN +P P
Sbjct: 549 ASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHN--------YPVWDTQFSPYGYYF 600
Query: 297 ASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQE 356
S D +LW+ D +P+ GH V +HP+ ++ T DR+ RLWD+
Sbjct: 601 VSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGN 660
Query: 357 EILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFS 416
+ GH ++ + F +G TG D +WD+ G + L+GH + + FS
Sbjct: 661 CVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFS 720
Query: 417 PNGYHIATGSGDNTCKVWD 435
+G +A+GS DNT ++WD
Sbjct: 721 RDGEILASGSMDNTVRLWD 739
Score = 83.2 bits (204), Expect = 5e-16
Identities = 44/144 (30%), Positives = 70/144 (48%), Gaps = 1/144 (0%)
Query: 376 DGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWD 435
D SL D R+ D +T + L GH +YG +FSP+ ++ + S D T ++W
Sbjct: 512 DLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWS 571
Query: 436 LRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKV 495
L+ C+ H V +F P +G + ++G +D A++W + PL+ AGH V
Sbjct: 572 LQTFTCLVGYKGHNYPVWDTQFSP-YGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADV 630
Query: 496 MGLDISSDGQLIATCSYDRTFKLW 519
+ +AT S DRT +LW
Sbjct: 631 NCTRFHPNSNYVATGSADRTVRLW 654
Score = 42.4 bits (98), Expect = 0.001
Identities = 35/156 (22%), Positives = 61/156 (39%), Gaps = 12/156 (7%)
Query: 367 GVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGS 426
G+ + D SL G D+ RVW + K++ + + + I S
Sbjct: 472 GLTAVDVTDDSSLIAGGFADSTVRVWSVTP-----------KKLRSVKQASDLSLIDKES 520
Query: 427 GDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLK 486
D ++ D + + + H V G F P N+LL+ + D T ++W+ ++ L
Sbjct: 521 DDVLERIMDEKTASELKILYGHSGPVYGASFSPDR-NYLLSSSEDGTVRLWSLQTFTCLV 579
Query: 487 TLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE 522
GH V S G + +DR +LW +
Sbjct: 580 GYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATD 615
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 110 bits (276), Expect = 2e-24
Identities = 74/259 (28%), Positives = 115/259 (44%), Gaps = 13/259 (5%)
Query: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVS 288
G P+ +C FSP+ + A+A +LW V L L+GH +V TVS
Sbjct: 61 GHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSV--------ETVS 112
Query: 289 LDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWR 348
P LAS D V LW + S + + + GH + + P+ L T +D +
Sbjct: 113 FSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVH 172
Query: 349 LWDLE-AQEEILHQ--EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEG 405
+WDL + HQ EGHS + + + G LA +G D +W T ++ L+G
Sbjct: 173 IWDLRMVTPAVSHQALEGHSANISCLCYSASGLLA-SGSWDKTIHIWKPTTSSLLIQLKG 231
Query: 406 HLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFL 465
H+ + I FSP+ +A+ KVWD +C+ T+ ++ F P G L
Sbjct: 232 HVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTP-DGKIL 290
Query: 466 LTGAYDNTAKIWTHPGWSP 484
++GA D T + + SP
Sbjct: 291 VSGAADQTRRQISRTSKSP 309
Score = 101 bits (252), Expect = 1e-21
Identities = 66/235 (28%), Positives = 105/235 (44%), Gaps = 5/235 (2%)
Query: 288 SLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSW 347
+ P L + + DG V W S + + + GHT V + P G + D +
Sbjct: 28 AFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTV 87
Query: 348 RLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHL 407
RLWD+ + + +GH V ++F D +GG D +WD+++G+ + L GH
Sbjct: 88 RLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHR 147
Query: 408 KEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYT---IPAHQNLVTGVKFEPIHGNF 464
I +FSP +ATGS D+T +WDLR + + H ++ + +
Sbjct: 148 DSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSA--SGL 205
Query: 465 LLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
L +G++D T IW S L L GH V + S D +A+ Y R K+W
Sbjct: 206 LASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVW 260
Score = 92.4 bits (228), Expect = 9e-19
Identities = 55/201 (27%), Positives = 96/201 (47%), Gaps = 5/201 (2%)
Query: 322 HTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAG 381
H V + P G+ L T D W+ + + + GH+ V F DG L
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 382 TGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRC 441
+ D R+WD+ +C+ L+GH + + ++FSP+ +A+G D +WD++ +
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
Query: 442 VYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPL---KTLAGHEGKVMGL 498
+ + H++ + F P N L TG++D+T IW +P + L GH + L
Sbjct: 140 LRLLVGHRDSIQSSDFSPT-VNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCL 198
Query: 499 DISSDGQLIATCSYDRTFKLW 519
S+ G L+A+ S+D+T +W
Sbjct: 199 CYSASG-LLASGSWDKTIHIW 218
Score = 92.4 bits (228), Expect = 9e-19
Identities = 72/280 (25%), Positives = 116/280 (41%), Gaps = 13/280 (4%)
Query: 239 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLAS 298
FSP+ +ML T G W LL L GH V F P + AS
Sbjct: 29 FSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHL--------FAS 80
Query: 299 CAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEI 358
+ D +V+LW + + + ++GH V V + P R L + +D+ LWD+++ + +
Sbjct: 81 ASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQML 140
Query: 359 LHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLR---TGRCIMFLEGHLKEIYGINF 415
GH + F + TG D+ +WDLR LEGH I + +
Sbjct: 141 RLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCY 200
Query: 416 SPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAK 475
S +G +A+GS D T +W + + H V + F P +L + Y K
Sbjct: 201 SASGL-LASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSP-DELWLASAGYSRMVK 258
Query: 476 IWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRT 515
+W L+TL G + DG+++ + + D+T
Sbjct: 259 VWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQT 298
Score = 58.5 bits (140), Expect = 1e-08
Identities = 33/122 (27%), Positives = 56/122 (45%), Gaps = 1/122 (0%)
Query: 398 RCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKF 457
R + F H E+ FSP+G + TGS D W+ R + ++ + H V +F
Sbjct: 12 RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRF 71
Query: 458 EPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFK 517
P G+ + + D T ++W L+ L GH+ V + S D + +A+ +D+
Sbjct: 72 SP-DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVM 130
Query: 518 LW 519
LW
Sbjct: 131 LW 132
Score = 53.1 bits (126), Expect = 6e-07
Identities = 36/162 (22%), Positives = 62/162 (38%), Gaps = 12/162 (7%)
Query: 228 IGDDRPISYCHFSPNSKMLATACWSGLCKLWS---VPDCNLLHTLRGHNTNVGAIVFHPK 284
+G I FSP LAT W +W V L GH+ N+ + +
Sbjct: 144 VGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSAS 203
Query: 285 STVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYD 344
LAS + D ++ +W + + ++GH V + + P +L + Y
Sbjct: 204 GL---------LASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYS 254
Query: 345 RSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLD 386
R ++WD + + +G + AF DG + +G D
Sbjct: 255 RMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAAD 296
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 110 bits (275), Expect = 3e-24
Identities = 68/233 (29%), Positives = 110/233 (47%), Gaps = 3/233 (1%)
Query: 287 VSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRS 346
++++P + + +AD ++K+W L S + + GH V V+ +L + D+
Sbjct: 210 IAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQ 269
Query: 347 WRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGH 406
+ WDLE + I H GH VY + H + T D+ R+WD+RT + L GH
Sbjct: 270 VKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGH 329
Query: 407 LKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLL 466
+ + I TGS D T ++WDL + T+ H+ V V P H F
Sbjct: 330 TNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTF-A 388
Query: 467 TGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
+G+ DN K W P S ++ L+GH + L ++SDG L++ + T LW
Sbjct: 389 SGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGAD-NGTMHLW 439
Score = 85.9 bits (211), Expect = 8e-17
Identities = 54/201 (26%), Positives = 89/201 (44%), Gaps = 2/201 (0%)
Query: 319 IEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGS 378
I GH V + P ++ T DR+ ++WDL + + L GH V +
Sbjct: 200 ISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSP 259
Query: 379 LAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQ 438
+ G D + WDL + I GHL +YG++ P + T S D+T ++WD+R
Sbjct: 260 YLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRT 319
Query: 439 RRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGL 498
+ V+T+ H N V V+ + ++TG++D T ++W TL H+ V +
Sbjct: 320 KASVHTLSGHTNAVATVRCQAAEPQ-IITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAV 378
Query: 499 DISSDGQLIATCSYDRTFKLW 519
+ A+ S D K W
Sbjct: 379 VLHPRHYTFASGSPD-NIKQW 398
Score = 85.5 bits (210), Expect = 1e-16
Identities = 58/237 (24%), Positives = 95/237 (40%), Gaps = 11/237 (4%)
Query: 241 PNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCA 300
P ++ T K+W + L +L GH + V ++ +S L SC
Sbjct: 214 PGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPY--------LFSCG 265
Query: 301 ADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILH 360
D VK W L+ ++ + GH V + HP+ L T D + R+WD+ + +
Sbjct: 266 EDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHT 325
Query: 361 QEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGY 420
GH+ V + TG D R+WDL G+ + L H K + + P Y
Sbjct: 326 LSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHY 385
Query: 421 HIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIW 477
A+GS DN K W + + H ++ + L++GA + T +W
Sbjct: 386 TFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLTVN--SDGVLVSGADNGTMHLW 439
Score = 49.7 bits (117), Expect = 7e-06
Identities = 43/202 (21%), Positives = 77/202 (38%), Gaps = 18/202 (8%)
Query: 241 PNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCA 300
P +L T ++W V +HTL GH V +TV + + + +
Sbjct: 298 PTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAV--------ATVRCQAAEPQIITGS 349
Query: 301 ADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILH 360
D +++LW L + + + H V V+ HP + D + + W I +
Sbjct: 350 HDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPD-NIKQWKFPDGSFIQN 408
Query: 361 QEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKE--------IYG 412
GH+ + + + DG L +G + +WD RTG + ++ I+
Sbjct: 409 LSGHNAIINTLTVNSDGVLV-SGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFA 467
Query: 413 INFSPNGYHIATGSGDNTCKVW 434
F + + T D T KV+
Sbjct: 468 CAFDQSESRLLTAEADKTIKVY 489
Score = 39.7 bits (91), Expect = 0.007
Identities = 25/79 (31%), Positives = 36/79 (45%), Gaps = 3/79 (3%)
Query: 445 IPAHQNLVTGVKFEPIHGN-FLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSD 503
I H V + EP GN + +TG+ D T KIW +L GH V G+ +S+
Sbjct: 200 ISGHLGWVRCIAVEP--GNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTR 257
Query: 504 GQLIATCSYDRTFKLWMAE 522
+ +C D+ K W E
Sbjct: 258 SPYLFSCGEDKQVKCWDLE 276
Score = 35.8 bits (81), Expect = 0.098
Identities = 15/41 (36%), Positives = 21/41 (51%)
Query: 479 HPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
HP W + ++GH G V + + Q T S DRT K+W
Sbjct: 191 HPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIW 231
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 109 bits (272), Expect = 7e-24
Identities = 76/281 (27%), Positives = 118/281 (41%), Gaps = 9/281 (3%)
Query: 239 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLAS 298
FS N+K LA+ +W + + + GH V + F P + LAS
Sbjct: 27 FSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL--------LAS 78
Query: 299 CAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEI 358
+ D +V++W + HT V V + G+ T D++ ++W Q+ +
Sbjct: 79 GSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFL 138
Query: 359 LHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPN 418
H V F DG L + D ++WD + C+ H + ++F P+
Sbjct: 139 FSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPS 198
Query: 419 GYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWT 478
G IA DNT KVWD+R R + H V G+ F P GN+L+T + D+T KI
Sbjct: 199 GTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHP-SGNYLITASSDSTLKILD 257
Query: 479 HPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
L TL GH+G + S G+ A+ D +W
Sbjct: 258 LMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 105 bits (262), Expect = 1e-22
Identities = 66/250 (26%), Positives = 115/250 (46%), Gaps = 11/250 (4%)
Query: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTL-RGHNTNVGAIVFHPKSTV 287
G ++ +FSP+ +LA+ ++W VP+ T+ R H V ++ F
Sbjct: 59 GHKDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQS 117
Query: 288 SLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSW 347
+ D D +VK+W+ + + + H V + P GR + + D++
Sbjct: 118 FVTASD--------DKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTV 169
Query: 348 RLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHL 407
+LWD ++E + H V + FH G+ G+D +VWD+RT R + + H
Sbjct: 170 KLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHS 229
Query: 408 KEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLT 467
+ G++F P+G ++ T S D+T K+ DL + R +YT+ HQ T V F G + +
Sbjct: 230 AAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRT-GEYFAS 288
Query: 468 GAYDNTAKIW 477
G D +W
Sbjct: 289 GGSDEQVMVW 298
Score = 103 bits (258), Expect = 3e-22
Identities = 73/257 (28%), Positives = 105/257 (40%), Gaps = 9/257 (3%)
Query: 262 DCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEG 321
D +L +GH V + F S++ K LAS + D + +W + G
Sbjct: 8 DPSLERHFKGHRDAVTCVDF------SINTKQ--LASGSMDSCLMVWHMKPQSRAYRFTG 59
Query: 322 HTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAG 381
H V V + PSG L + D++ R+W + E H+ V + F DG
Sbjct: 60 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV 119
Query: 382 TGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRC 441
T D +VW + + L H+ + FSP+G I + S D T K+WD R C
Sbjct: 120 TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSREC 179
Query: 442 VYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDIS 501
V++ H VT V F P G + DNT K+W L+ H V GL
Sbjct: 180 VHSYCEHGGFVTYVDFHP-SGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFH 238
Query: 502 SDGQLIATCSYDRTFKL 518
G + T S D T K+
Sbjct: 239 PSGNYLITASSDSTLKI 255
Score = 83.6 bits (205), Expect = 4e-16
Identities = 55/223 (24%), Positives = 88/223 (39%), Gaps = 11/223 (4%)
Query: 297 ASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQE 356
A CA D S++ +GH V V + + + L + D +W ++ Q
Sbjct: 3 APCAEDPSLE----------RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQS 52
Query: 357 EILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFS 416
GH V + F G L +G D R+W H + ++F
Sbjct: 53 RAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFC 112
Query: 417 PNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKI 476
+G T S D T KVW +++ ++++ H N V KF P G +++ + D T K+
Sbjct: 113 SDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP-DGRLIVSASDDKTVKL 171
Query: 477 WTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
W + + H G V +D G IA D T K+W
Sbjct: 172 WDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVW 214
Score = 39.7 bits (91), Expect = 0.007
Identities = 22/73 (30%), Positives = 38/73 (52%), Gaps = 1/73 (1%)
Query: 448 HQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLI 507
H++ VT V F I+ L +G+ D+ +W S GH+ V ++ S G L+
Sbjct: 18 HRDAVTCVDFS-INTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
Query: 508 ATCSYDRTFKLWM 520
A+ S D+T ++W+
Sbjct: 77 ASGSRDKTVRIWV 89
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 109 bits (272), Expect = 7e-24
Identities = 76/281 (27%), Positives = 118/281 (41%), Gaps = 9/281 (3%)
Query: 239 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLAS 298
FS N+K LA+ +W + + + GH V + F P + LAS
Sbjct: 27 FSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL--------LAS 78
Query: 299 CAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEI 358
+ D +V++W + HT V V + G+ T D++ ++W Q+ +
Sbjct: 79 GSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFL 138
Query: 359 LHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPN 418
H V F DG L + D ++WD + C+ H + ++F P+
Sbjct: 139 FSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPS 198
Query: 419 GYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWT 478
G IA DNT KVWD+R R + H V G+ F P GN+L+T + D+T KI
Sbjct: 199 GTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHP-SGNYLITASSDSTLKILD 257
Query: 479 HPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
L TL GH+G + S G+ A+ D +W
Sbjct: 258 LMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 105 bits (262), Expect = 1e-22
Identities = 66/250 (26%), Positives = 115/250 (46%), Gaps = 11/250 (4%)
Query: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTL-RGHNTNVGAIVFHPKSTV 287
G ++ +FSP+ +LA+ ++W VP+ T+ R H V ++ F
Sbjct: 59 GHKDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQS 117
Query: 288 SLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSW 347
+ D D +VK+W+ + + + H V + P GR + + D++
Sbjct: 118 FVTASD--------DKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTV 169
Query: 348 RLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHL 407
+LWD ++E + H V + FH G+ G+D +VWD+RT R + + H
Sbjct: 170 KLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHS 229
Query: 408 KEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLT 467
+ G++F P+G ++ T S D+T K+ DL + R +YT+ HQ T V F G + +
Sbjct: 230 AAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRT-GEYFAS 288
Query: 468 GAYDNTAKIW 477
G D +W
Sbjct: 289 GGSDEQVMVW 298
Score = 103 bits (258), Expect = 3e-22
Identities = 73/257 (28%), Positives = 105/257 (40%), Gaps = 9/257 (3%)
Query: 262 DCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEG 321
D +L +GH V + F S++ K LAS + D + +W + G
Sbjct: 8 DPSLERHFKGHRDAVTCVDF------SINTKQ--LASGSMDSCLMVWHMKPQSRAYRFTG 59
Query: 322 HTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAG 381
H V V + PSG L + D++ R+W + E H+ V + F DG
Sbjct: 60 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV 119
Query: 382 TGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRC 441
T D +VW + + L H+ + FSP+G I + S D T K+WD R C
Sbjct: 120 TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSREC 179
Query: 442 VYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDIS 501
V++ H VT V F P G + DNT K+W L+ H V GL
Sbjct: 180 VHSYCEHGGFVTYVDFHP-SGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFH 238
Query: 502 SDGQLIATCSYDRTFKL 518
G + T S D T K+
Sbjct: 239 PSGNYLITASSDSTLKI 255
Score = 83.6 bits (205), Expect = 4e-16
Identities = 55/223 (24%), Positives = 88/223 (39%), Gaps = 11/223 (4%)
Query: 297 ASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQE 356
A CA D S++ +GH V V + + + L + D +W ++ Q
Sbjct: 3 APCAEDPSLE----------RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQS 52
Query: 357 EILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFS 416
GH V + F G L +G D R+W H + ++F
Sbjct: 53 RAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFC 112
Query: 417 PNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKI 476
+G T S D T KVW +++ ++++ H N V KF P G +++ + D T K+
Sbjct: 113 SDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP-DGRLIVSASDDKTVKL 171
Query: 477 WTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
W + + H G V +D G IA D T K+W
Sbjct: 172 WDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVW 214
Score = 39.7 bits (91), Expect = 0.007
Identities = 22/73 (30%), Positives = 38/73 (52%), Gaps = 1/73 (1%)
Query: 448 HQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLI 507
H++ VT V F I+ L +G+ D+ +W S GH+ V ++ S G L+
Sbjct: 18 HRDAVTCVDFS-INTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
Query: 508 ATCSYDRTFKLWM 520
A+ S D+T ++W+
Sbjct: 77 ASGSRDKTVRIWV 89
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 106 bits (264), Expect = 6e-23
Identities = 74/309 (23%), Positives = 138/309 (44%), Gaps = 24/309 (7%)
Query: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCN--------LLHTLRGHNTNVGAIV 280
G + + C ++P S +LA+ ++W++ + + L H +R +V +
Sbjct: 167 GHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPS-- 224
Query: 281 FHPKSTVSLD--PKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFL 338
K SLD + LA+ + DG ++W+ D + + + H + + W+ G F+
Sbjct: 225 --NKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNL-ASTLGQHKGPIFALKWNKKGNFI 281
Query: 339 GTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGR 398
+ D++ +WD E HS D+ + + + A D V L R
Sbjct: 282 LSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCS-TDMCIHVCKLGQDR 340
Query: 399 CIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFE 458
I +GH E+ I + P G +A+ S D T K+W ++Q CV+ + AH + +K+
Sbjct: 341 PIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWS 400
Query: 459 PI-------HGNFLLTGA-YDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATC 510
P + N +L A +D+T ++W + TL H+ V + S DG+ +A+
Sbjct: 401 PTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASG 460
Query: 511 SYDRTFKLW 519
S+D+ +W
Sbjct: 461 SFDKCVHIW 469
Score = 92.8 bits (229), Expect = 7e-19
Identities = 57/259 (22%), Positives = 109/259 (42%), Gaps = 43/259 (16%)
Query: 228 IGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAI-------- 279
+ ++ ++ ++ +LAT + G ++W+ D NL TL H + A+
Sbjct: 222 VPSNKDVTSLDWNSEGTLLATGSYDGFARIWT-KDGNLASTLGQHKGPIFALKWNKKGNF 280
Query: 280 ------------------------VFHPKSTVSLDPKDVN-LASCAADGSVKLWSLDSDE 314
FH + +D + N ASC+ D + + L D
Sbjct: 281 ILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDR 340
Query: 315 PVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFH 374
P+ +GHT V + W P+G L + D + ++W ++ + + H+ +Y I +
Sbjct: 341 PIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWS 400
Query: 375 QDGS---------LAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATG 425
G + + D+ R+WD+ G CI L H + +Y + FSP+G ++A+G
Sbjct: 401 PTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASG 460
Query: 426 SGDNTCKVWDLRQRRCVYT 444
S D +W+ + V++
Sbjct: 461 SFDKCVHIWNTQTGALVHS 479
Score = 81.3 bits (199), Expect = 2e-15
Identities = 49/182 (26%), Positives = 82/182 (45%), Gaps = 18/182 (9%)
Query: 266 LHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVR 325
+ T +GH V AI + P + LASC+ D ++K+WS+ D V D++ H
Sbjct: 342 IKTFQGHTNEVNAIKWDPTGNL--------LASCSDDMTLKIWSMKQDNCVHDLQAHNKE 393
Query: 326 VARVMWHPSGR---------FLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQD 376
+ + W P+G L + +D + RLWD++ I H VY +AF D
Sbjct: 394 IYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPD 453
Query: 377 GSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDL 436
G +G D +W+ +TG + G I+ + ++ G + + D + V DL
Sbjct: 454 GRYLASGSFDKCVHIWNTQTGALVHSYRG-TGGIFEVCWNAAGDKVGASASDGSVCVLDL 512
Query: 437 RQ 438
R+
Sbjct: 513 RK 514
Score = 72.8 bits (177), Expect = 7e-13
Identities = 58/244 (23%), Positives = 95/244 (38%), Gaps = 22/244 (9%)
Query: 295 NLASCAADGSVKLWSLDSDEPVAD-----IEGHTVRVARVMWHPSGRFLGTTCYDRSWRL 349
N A A+ + +D D + + GH V W+P L + D + R+
Sbjct: 136 NGAHTIANNHTDMMEVDGDVEIPPNKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARI 195
Query: 350 WDL-------EAQEEILH--QEG-----HSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLR 395
W+L Q + H +EG + V + ++ +G+L TG D F R+W +
Sbjct: 196 WNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIW-TK 254
Query: 396 TGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGV 455
G L H I+ + ++ G I + D T +WD P H V
Sbjct: 255 DGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDV 314
Query: 456 KFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRT 515
++ N + + D + P+KT GH +V + G L+A+CS D T
Sbjct: 315 DWQ--SNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMT 372
Query: 516 FKLW 519
K+W
Sbjct: 373 LKIW 376
Score = 64.3 bits (155), Expect = 3e-10
Identities = 40/134 (29%), Positives = 68/134 (50%), Gaps = 18/134 (13%)
Query: 403 LEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQ-----------RRCV----YTIPA 447
L GH E++ ++P +A+GSGD+T ++W+L + R C+ +P+
Sbjct: 165 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPS 224
Query: 448 HQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLI 507
+++ VT + + G L TG+YD A+IWT G + TL H+G + L + G I
Sbjct: 225 NKD-VTSLDWNS-EGTLLATGSYDGFARIWTKDG-NLASTLGQHKGPIFALKWNKKGNFI 281
Query: 508 ATCSYDRTFKLWMA 521
+ D+T +W A
Sbjct: 282 LSAGVDKTTIIWDA 295
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 105 bits (262), Expect = 1e-22
Identities = 66/250 (26%), Positives = 115/250 (46%), Gaps = 11/250 (4%)
Query: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTL-RGHNTNVGAIVFHPKSTV 287
G ++ +FSP+ +LA+ ++W VP+ T+ R H V ++ F
Sbjct: 21 GHKDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQS 79
Query: 288 SLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSW 347
+ D D +VK+W+ + + + H V + P GR + + D++
Sbjct: 80 FVTASD--------DKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTV 131
Query: 348 RLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHL 407
+LWD ++E + H V + FH G+ G+D +VWD+RT R + + H
Sbjct: 132 KLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHS 191
Query: 408 KEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLT 467
+ G++F P+G ++ T S D+T K+ DL + R +YT+ HQ T V F G + +
Sbjct: 192 AAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRT-GEYFAS 250
Query: 468 GAYDNTAKIW 477
G D +W
Sbjct: 251 GGSDEQVMVW 260
Score = 100 bits (249), Expect = 3e-21
Identities = 70/263 (26%), Positives = 110/263 (41%), Gaps = 9/263 (3%)
Query: 257 LWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPV 316
+W + + + GH V + F P + LAS + D +V++W +
Sbjct: 7 VWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL--------LASGSRDKTVRIWVPNVKGES 58
Query: 317 ADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQD 376
HT V V + G+ T D++ ++W Q+ + H V F D
Sbjct: 59 TVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPD 118
Query: 377 GSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDL 436
G L + D ++WD + C+ H + ++F P+G IA DNT KVWD+
Sbjct: 119 GRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 178
Query: 437 RQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVM 496
R R + H V G+ F P GN+L+T + D+T KI L TL GH+G
Sbjct: 179 RTHRLLQHYQLHSAAVNGLSFHP-SGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 237
Query: 497 GLDISSDGQLIATCSYDRTFKLW 519
+ S G+ A+ D +W
Sbjct: 238 TVAFSRTGEYFASGGSDEQVMVW 260
Score = 98.6 bits (244), Expect = 1e-20
Identities = 62/217 (28%), Positives = 88/217 (40%), Gaps = 1/217 (0%)
Query: 302 DGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQ 361
D + +W + GH V V + PSG L + D++ R+W + E
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
Query: 362 EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYH 421
H+ V + F DG T D +VW + + L H+ + FSP+G
Sbjct: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
Query: 422 IATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPG 481
I + S D T K+WD R CV++ H VT V F P G + DNT K+W
Sbjct: 122 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHP-SGTCIAAAGMDNTVKVWDVRT 180
Query: 482 WSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKL 518
L+ H V GL G + T S D T K+
Sbjct: 181 HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKI 217
Score = 79.7 bits (195), Expect = 6e-15
Identities = 45/176 (25%), Positives = 71/176 (40%), Gaps = 1/176 (0%)
Query: 344 DRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFL 403
D +W ++ Q GH V + F G L +G D R+W
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
Query: 404 EGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGN 463
H + ++F +G T S D T KVW +++ ++++ H N V KF P G
Sbjct: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP-DGR 120
Query: 464 FLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
+++ + D T K+W + + H G V +D G IA D T K+W
Sbjct: 121 LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVW 176
Score = 66.6 bits (161), Expect = 5e-11
Identities = 42/135 (31%), Positives = 63/135 (46%), Gaps = 1/135 (0%)
Query: 385 LDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYT 444
+D+ VW ++ GH + +NFSP+G+ +A+GS D T ++W +
Sbjct: 1 MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 60
Query: 445 IPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDG 504
AH V V F G +T + D T K+W L +L+ H V S DG
Sbjct: 61 FRAHTATVRSVHFCS-DGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 119
Query: 505 QLIATCSYDRTFKLW 519
+LI + S D+T KLW
Sbjct: 120 RLIVSASDDKTVKLW 134
Score = 31.2 bits (69), Expect = 2.4
Identities = 14/50 (28%), Positives = 25/50 (50%)
Query: 471 DNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWM 520
D+ +W S GH+ V ++ S G L+A+ S D+T ++W+
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWV 51
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 104 bits (260), Expect = 2e-22
Identities = 82/307 (26%), Positives = 143/307 (46%), Gaps = 28/307 (9%)
Query: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSV-PDCNLLHTLRGHNTNVGAIVFHPKSTV 287
G + + C F PN LA+A + L LW+V DC+ TL+GH+ V + ++ ++
Sbjct: 64 GHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSM 123
Query: 288 SLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCY---D 344
L S + D +V +W ++ E V ++GHT V +P+ R C D
Sbjct: 124 --------LFSASTDKTVAVWDSETGERVKRLKGHTSFVNSC--YPARRGPQLVCTGSDD 173
Query: 345 RSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLE 404
+ +LWD+ + I + ++ V + F+ +GG+D +VWDLR + +
Sbjct: 174 GTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMR 232
Query: 405 GHLKEIYGINFSPNGYHIATGSGDNTCKVWDLR----QRRCVYTIPAH-----QNLVTGV 455
GH + G++ S G ++ + + DNT +VWD+R + RCV + +NL+
Sbjct: 233 GHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLR-C 291
Query: 456 KFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRT 515
+ P G+ + G+ D +W L L GH G + + D +I + S D+
Sbjct: 292 SWSP-DGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDK- 349
Query: 516 FKLWMAE 522
+L+M E
Sbjct: 350 -RLYMGE 355
Score = 97.4 bits (241), Expect = 3e-20
Identities = 59/207 (28%), Positives = 99/207 (47%), Gaps = 4/207 (1%)
Query: 315 PVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQ-EEILHQEGHSMGVYDIAF 373
P+ + GH V +HP+G L + +DR LW++ + +GHS V ++ +
Sbjct: 58 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHY 117
Query: 374 HQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYH-IATGSGDNTCK 432
+ DGS+ + D VWD TG + L+GH + + G + TGS D T K
Sbjct: 118 NTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVK 177
Query: 433 VWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHE 492
+WD+R++ + T + V V F + +++G DN K+W T+ GH
Sbjct: 178 LWDIRKKAAIQTF-QNTYQVLAVTFNDT-SDQIISGGIDNDIKVWDLRQNKLTYTMRGHA 235
Query: 493 GKVMGLDISSDGQLIATCSYDRTFKLW 519
V GL +SS+G + + + D T ++W
Sbjct: 236 DSVTGLSLSSEGSYLLSNAMDNTVRVW 262
Score = 88.2 bits (217), Expect = 2e-17
Identities = 61/246 (24%), Positives = 107/246 (43%), Gaps = 16/246 (6%)
Query: 222 NNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVF 281
+N+ + G + H++ + ML +A +W + L+GH + V +
Sbjct: 100 DNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCY- 158
Query: 282 HPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTT 341
P+ V S DG+VKLW + + + +T +V V ++ + + +
Sbjct: 159 ----PARRGPQLVCTGS--DDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISG 211
Query: 342 CYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLR----TG 397
D ++WDL + GH+ V ++ +GS + +D RVWD+R
Sbjct: 212 GIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKE 271
Query: 398 RCIMFLEGHL----KEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVT 453
RC+ +G++ K + ++SP+G IA GS D VWD RR +Y +P H +
Sbjct: 272 RCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSIN 331
Query: 454 GVKFEP 459
V F P
Sbjct: 332 EVAFHP 337
Score = 33.1 bits (74), Expect = 0.63
Identities = 13/37 (35%), Positives = 21/37 (56%)
Query: 483 SPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
+P+ L+GHEG+V +G +A+ +DR LW
Sbjct: 57 APIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLW 93
>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
isoform a [Homo sapiens]
Length = 353
Score = 103 bits (256), Expect = 5e-22
Identities = 69/225 (30%), Positives = 112/225 (49%), Gaps = 11/225 (4%)
Query: 304 SVKLWSLDSDEPVA----DIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEIL 359
SV + D +E +A + HT ++ + S + T D + LWD+E+ + +
Sbjct: 130 SVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQ 189
Query: 360 HQEGHSMGVY--DIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSP 417
GH V D+A + G+ +GG D VWD+R+G+C+ E H +I + + P
Sbjct: 190 SFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYP 249
Query: 418 NGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTG---VKFEPIHGNFLLTGAYDNTA 474
+G A+GS D TC+++DLR R V I + ++++ G V F + G L G D T
Sbjct: 250 SGDAFASGSDDATCRLYDLRADREV-AIYSKESIIFGASSVDFS-LSGRLLFAGYNDYTI 307
Query: 475 KIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
+W S + L GHE +V L +S DG + S+D T ++W
Sbjct: 308 NVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
Score = 92.0 bits (227), Expect = 1e-18
Identities = 59/203 (29%), Positives = 86/203 (42%), Gaps = 8/203 (3%)
Query: 234 ISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKD 293
+S C F+ + + TA G C LW V LL + GH +V + P T +
Sbjct: 156 LSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGN----- 210
Query: 294 VNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLE 353
S D +W + S + V E H + V ++PSG + D + RL+DL
Sbjct: 211 -TFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLR 269
Query: 354 AQEE--ILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIY 411
A E I +E G + F G L G D VWD+ G + L GH +
Sbjct: 270 ADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVS 329
Query: 412 GINFSPNGYHIATGSGDNTCKVW 434
+ SP+G +GS D+T +VW
Sbjct: 330 TLRVSPDGTAFCSGSWDHTLRVW 352
Score = 42.4 bits (98), Expect = 0.001
Identities = 31/119 (26%), Positives = 49/119 (41%), Gaps = 21/119 (17%)
Query: 415 FSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFL--------- 465
++P+G IA G DN C V+ L T ++N+ K +H N+L
Sbjct: 113 YAPSGCAIACGGLDNKCSVYPL-------TFDKNENMAAKKKSVAMHTNYLSACSFTNSD 165
Query: 466 ---LTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDI--SSDGQLIATCSYDRTFKLW 519
LT + D T +W L++ GH V+ LD+ S G + D+ +W
Sbjct: 166 MQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVW 224
>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
isoform b [Homo sapiens]
Length = 395
Score = 103 bits (256), Expect = 5e-22
Identities = 69/225 (30%), Positives = 112/225 (49%), Gaps = 11/225 (4%)
Query: 304 SVKLWSLDSDEPVA----DIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEIL 359
SV + D +E +A + HT ++ + S + T D + LWD+E+ + +
Sbjct: 172 SVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQ 231
Query: 360 HQEGHSMGVY--DIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSP 417
GH V D+A + G+ +GG D VWD+R+G+C+ E H +I + + P
Sbjct: 232 SFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYP 291
Query: 418 NGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTG---VKFEPIHGNFLLTGAYDNTA 474
+G A+GS D TC+++DLR R V I + ++++ G V F + G L G D T
Sbjct: 292 SGDAFASGSDDATCRLYDLRADREV-AIYSKESIIFGASSVDFS-LSGRLLFAGYNDYTI 349
Query: 475 KIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
+W S + L GHE +V L +S DG + S+D T ++W
Sbjct: 350 NVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
Score = 92.0 bits (227), Expect = 1e-18
Identities = 59/203 (29%), Positives = 86/203 (42%), Gaps = 8/203 (3%)
Query: 234 ISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKD 293
+S C F+ + + TA G C LW V LL + GH +V + P T +
Sbjct: 198 LSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGN----- 252
Query: 294 VNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLE 353
S D +W + S + V E H + V ++PSG + D + RL+DL
Sbjct: 253 -TFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLR 311
Query: 354 AQEE--ILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIY 411
A E I +E G + F G L G D VWD+ G + L GH +
Sbjct: 312 ADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVS 371
Query: 412 GINFSPNGYHIATGSGDNTCKVW 434
+ SP+G +GS D+T +VW
Sbjct: 372 TLRVSPDGTAFCSGSWDHTLRVW 394
Score = 42.4 bits (98), Expect = 0.001
Identities = 31/119 (26%), Positives = 49/119 (41%), Gaps = 21/119 (17%)
Query: 415 FSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFL--------- 465
++P+G IA G DN C V+ L T ++N+ K +H N+L
Sbjct: 155 YAPSGCAIACGGLDNKCSVYPL-------TFDKNENMAAKKKSVAMHTNYLSACSFTNSD 207
Query: 466 ---LTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDI--SSDGQLIATCSYDRTFKLW 519
LT + D T +W L++ GH V+ LD+ S G + D+ +W
Sbjct: 208 MQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVW 266
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 101 bits (251), Expect = 2e-21
Identities = 63/280 (22%), Positives = 127/280 (45%), Gaps = 11/280 (3%)
Query: 242 NSKMLATACWSGLCKLWSVPD--CNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASC 299
NS+ + T L K+W D +L +L GH V ++ ++ AS
Sbjct: 31 NSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIA--------ASS 82
Query: 300 AADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEIL 359
+ D ++LW L++ + + I+ V + + P ++L T + ++ +E+ ++
Sbjct: 83 SLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEY 142
Query: 360 HQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNG 419
+ + IA+ DG +G +D ++D+ TG+ + LEGH I + FSP+
Sbjct: 143 SLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDS 202
Query: 420 YHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTH 479
+ T S D K++D++ T+ H + V V F P +F ++ + D + K+W
Sbjct: 203 QLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHF-VSSSSDKSVKVWDV 261
Query: 480 PGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
+ + T H+ +V G+ + +G I + D+ ++
Sbjct: 262 GTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
Score = 87.0 bits (214), Expect = 4e-17
Identities = 51/196 (26%), Positives = 96/196 (48%), Gaps = 3/196 (1%)
Query: 286 TVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDR 345
T++ P LA+ G V ++ ++S + ++ + + + P G++L + D
Sbjct: 111 TLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDG 170
Query: 346 SWRLWDLEAQEEILHQ-EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLE 404
++D+ A ++LH EGH+M + + F D L T D + +++D++ L
Sbjct: 171 IINIFDI-ATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLS 229
Query: 405 GHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNF 464
GH + + F P+ H + S D + KVWD+ R CV+T HQ+ V GVK+ +G+
Sbjct: 230 GHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNG-NGSK 288
Query: 465 LLTGAYDNTAKIWTHP 480
+++ D I+ P
Sbjct: 289 IVSVGDDQEIHIYDCP 304
Score = 70.9 bits (172), Expect = 3e-12
Identities = 45/197 (22%), Positives = 89/197 (45%), Gaps = 8/197 (4%)
Query: 239 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLAS 298
FSP+S+ LAT G ++ V ++L + +I + P LAS
Sbjct: 114 FSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKY--------LAS 165
Query: 299 CAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEI 358
A DG + ++ + + + + +EGH + + + + P + L T D +++D++
Sbjct: 166 GAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLA 225
Query: 359 LHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPN 418
GH+ V ++AF D + + D +VWD+ T C+ H +++G+ ++ N
Sbjct: 226 GTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGN 285
Query: 419 GYHIATGSGDNTCKVWD 435
G I + D ++D
Sbjct: 286 GSKIVSVGDDQEIHIYD 302
Score = 51.6 bits (122), Expect = 2e-06
Identities = 36/123 (29%), Positives = 58/123 (47%), Gaps = 8/123 (6%)
Query: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVS 288
G PI FSP+S++L TA G K++ V NL TL GH + V V+
Sbjct: 188 GHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWV--------LNVA 239
Query: 289 LDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWR 348
P D + S ++D SVK+W + + V H +V V ++ +G + + D+
Sbjct: 240 FCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIH 299
Query: 349 LWD 351
++D
Sbjct: 300 IYD 302
Score = 32.0 bits (71), Expect = 1.4
Identities = 27/104 (25%), Positives = 41/104 (39%), Gaps = 9/104 (8%)
Query: 411 YGINFSPNGYHIATGSGDNTCKVWDLRQRR--CVYTIPAHQNLVTGVKFE---PIHGNFL 465
+G N N + TGS D+ KVW R R +++ HQ V V PI
Sbjct: 24 WGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPI----A 79
Query: 466 LTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIAT 509
+ + D ++W +K++ L S D Q +AT
Sbjct: 80 ASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLAT 123
Score = 32.0 bits (71), Expect = 1.4
Identities = 19/63 (30%), Positives = 32/63 (50%), Gaps = 8/63 (12%)
Query: 465 LLTGAYDNTAKIWTHPGWSPLK-----TLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
++TG+ D+ K+W W + +L GH+ V+ +DIS + A+ S D +LW
Sbjct: 35 VVTGSLDDLVKVWK---WRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLW 91
Query: 520 MAE 522
E
Sbjct: 92 DLE 94
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 100 bits (250), Expect = 2e-21
Identities = 73/311 (23%), Positives = 138/311 (44%), Gaps = 28/311 (9%)
Query: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCN--------LLHTLR--GHNTNVGA 278
G + + C ++P S +LA+ ++W++ + + L H +R GH+
Sbjct: 179 GHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHD----- 233
Query: 279 IVFHPKSTVSLD--PKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGR 336
V K SLD LA+ + DG ++W+ D + + + H + + W+ G
Sbjct: 234 -VPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNL-ASTLGQHKGPIFALKWNRKGN 291
Query: 337 FLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRT 396
++ + D++ +WD E HS D+ + + + A D V L
Sbjct: 292 YILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCS-TDMCIHVCRLGC 350
Query: 397 GRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVK 456
R + +GH E+ I + P+G +A+ S D T K+W ++Q C++ + AH + +K
Sbjct: 351 DRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIK 410
Query: 457 FEPI-------HGNFLLTGA-YDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIA 508
+ P + N +L A +D+T ++W TL H+ V + S DG+ +A
Sbjct: 411 WSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLA 470
Query: 509 TCSYDRTFKLW 519
+ S+D+ +W
Sbjct: 471 SGSFDKCVHIW 481
Score = 95.9 bits (237), Expect = 8e-20
Identities = 59/259 (22%), Positives = 109/259 (42%), Gaps = 43/259 (16%)
Query: 228 IGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAI-------- 279
+ ++ ++ ++ N +LAT + G ++W+ D NL TL H + A+
Sbjct: 234 VPSNKDVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWNRKGNY 292
Query: 280 ------------------------VFHPKSTVSLD-PKDVNLASCAADGSVKLWSLDSDE 314
FH + +D + ASC+ D + + L D
Sbjct: 293 ILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDR 352
Query: 315 PVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFH 374
PV +GHT V + W PSG L + D + ++W ++ + I + H+ +Y I +
Sbjct: 353 PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWS 412
Query: 375 QDGS---------LAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATG 425
G + + D+ R+WD+ G C L H + +Y + FSP+G ++A+G
Sbjct: 413 PTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASG 472
Query: 426 SGDNTCKVWDLRQRRCVYT 444
S D +W+ + V++
Sbjct: 473 SFDKCVHIWNTQSGNLVHS 491
Score = 79.7 bits (195), Expect = 6e-15
Identities = 47/180 (26%), Positives = 81/180 (45%), Gaps = 18/180 (10%)
Query: 268 TLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVA 327
T +GH V AI + DP + LASC+ D ++K+WS+ + + D++ H +
Sbjct: 356 TFQGHTNEVNAIKW--------DPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIY 407
Query: 328 RVMWHPSGR---------FLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGS 378
+ W P+G L + +D + RLWD+E H VY +AF DG
Sbjct: 408 TIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGK 467
Query: 379 LAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQ 438
+G D +W+ ++G + G I+ + ++ G + + D + V DLR+
Sbjct: 468 YLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSVCVLDLRK 526
Score = 72.0 bits (175), Expect = 1e-12
Identities = 50/215 (23%), Positives = 84/215 (39%), Gaps = 17/215 (7%)
Query: 319 IEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQ----------EEILHQEGHSM-- 366
+ GH V W+P L + D + R+W+L + + GH +
Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 236
Query: 367 --GVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIAT 424
V + ++ +G+L TG D F R+W G L H I+ + ++ G +I +
Sbjct: 237 NKDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYILS 295
Query: 425 GSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSP 484
D T +WD P H V ++ + + + D + P
Sbjct: 296 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ--NNTTFASCSTDMCIHVCRLGCDRP 353
Query: 485 LKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
+KT GH +V + G L+A+CS D T K+W
Sbjct: 354 VKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 388
Score = 65.9 bits (159), Expect = 9e-11
Identities = 40/134 (29%), Positives = 70/134 (52%), Gaps = 18/134 (13%)
Query: 403 LEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQ-----------RRCV----YTIPA 447
L GH E++ ++P +A+GSGD+T ++W+L + R C+ + +P+
Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 236
Query: 448 HQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLI 507
+++ VT + + +G L TG+YD A+IWT G + TL H+G + L + G I
Sbjct: 237 NKD-VTSLDWN-TNGTLLATGSYDGFARIWTEDG-NLASTLGQHKGPIFALKWNRKGNYI 293
Query: 508 ATCSYDRTFKLWMA 521
+ D+T +W A
Sbjct: 294 LSAGVDKTTIIWDA 307
Score = 32.0 bits (71), Expect = 1.4
Identities = 21/73 (28%), Positives = 34/73 (46%), Gaps = 9/73 (12%)
Query: 233 PISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPK 292
P+ FSP+ K LA+ + +W+ NL+H+ RG G I V + +
Sbjct: 456 PVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG----TGGIF-----EVCWNAR 506
Query: 293 DVNLASCAADGSV 305
+ + A+DGSV
Sbjct: 507 GDKVGASASDGSV 519
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 100 bits (250), Expect = 2e-21
Identities = 73/311 (23%), Positives = 138/311 (44%), Gaps = 28/311 (9%)
Query: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCN--------LLHTLR--GHNTNVGA 278
G + + C ++P S +LA+ ++W++ + + L H +R GH+
Sbjct: 179 GHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHD----- 233
Query: 279 IVFHPKSTVSLD--PKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGR 336
V K SLD LA+ + DG ++W+ D + + + H + + W+ G
Sbjct: 234 -VPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNL-ASTLGQHKGPIFALKWNRKGN 291
Query: 337 FLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRT 396
++ + D++ +WD E HS D+ + + + A D V L
Sbjct: 292 YILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCS-TDMCIHVCRLGC 350
Query: 397 GRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVK 456
R + +GH E+ I + P+G +A+ S D T K+W ++Q C++ + AH + +K
Sbjct: 351 DRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIK 410
Query: 457 FEPI-------HGNFLLTGA-YDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIA 508
+ P + N +L A +D+T ++W TL H+ V + S DG+ +A
Sbjct: 411 WSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLA 470
Query: 509 TCSYDRTFKLW 519
+ S+D+ +W
Sbjct: 471 SGSFDKCVHIW 481
Score = 95.9 bits (237), Expect = 8e-20
Identities = 59/259 (22%), Positives = 109/259 (42%), Gaps = 43/259 (16%)
Query: 228 IGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAI-------- 279
+ ++ ++ ++ N +LAT + G ++W+ D NL TL H + A+
Sbjct: 234 VPSNKDVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWNRKGNY 292
Query: 280 ------------------------VFHPKSTVSLD-PKDVNLASCAADGSVKLWSLDSDE 314
FH + +D + ASC+ D + + L D
Sbjct: 293 ILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDR 352
Query: 315 PVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFH 374
PV +GHT V + W PSG L + D + ++W ++ + I + H+ +Y I +
Sbjct: 353 PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWS 412
Query: 375 QDGS---------LAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATG 425
G + + D+ R+WD+ G C L H + +Y + FSP+G ++A+G
Sbjct: 413 PTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASG 472
Query: 426 SGDNTCKVWDLRQRRCVYT 444
S D +W+ + V++
Sbjct: 473 SFDKCVHIWNTQSGNLVHS 491
Score = 79.7 bits (195), Expect = 6e-15
Identities = 47/180 (26%), Positives = 81/180 (45%), Gaps = 18/180 (10%)
Query: 268 TLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVA 327
T +GH V AI + DP + LASC+ D ++K+WS+ + + D++ H +
Sbjct: 356 TFQGHTNEVNAIKW--------DPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIY 407
Query: 328 RVMWHPSGR---------FLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGS 378
+ W P+G L + +D + RLWD+E H VY +AF DG
Sbjct: 408 TIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGK 467
Query: 379 LAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQ 438
+G D +W+ ++G + G I+ + ++ G + + D + V DLR+
Sbjct: 468 YLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSVCVLDLRK 526
Score = 72.0 bits (175), Expect = 1e-12
Identities = 50/215 (23%), Positives = 84/215 (39%), Gaps = 17/215 (7%)
Query: 319 IEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQ----------EEILHQEGHSM-- 366
+ GH V W+P L + D + R+W+L + + GH +
Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 236
Query: 367 --GVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIAT 424
V + ++ +G+L TG D F R+W G L H I+ + ++ G +I +
Sbjct: 237 NKDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYILS 295
Query: 425 GSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSP 484
D T +WD P H V ++ + + + D + P
Sbjct: 296 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ--NNTTFASCSTDMCIHVCRLGCDRP 353
Query: 485 LKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
+KT GH +V + G L+A+CS D T K+W
Sbjct: 354 VKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 388
Score = 65.9 bits (159), Expect = 9e-11
Identities = 40/134 (29%), Positives = 70/134 (52%), Gaps = 18/134 (13%)
Query: 403 LEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQ-----------RRCV----YTIPA 447
L GH E++ ++P +A+GSGD+T ++W+L + R C+ + +P+
Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 236
Query: 448 HQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLI 507
+++ VT + + +G L TG+YD A+IWT G + TL H+G + L + G I
Sbjct: 237 NKD-VTSLDWN-TNGTLLATGSYDGFARIWTEDG-NLASTLGQHKGPIFALKWNRKGNYI 293
Query: 508 ATCSYDRTFKLWMA 521
+ D+T +W A
Sbjct: 294 LSAGVDKTTIIWDA 307
Score = 32.0 bits (71), Expect = 1.4
Identities = 21/73 (28%), Positives = 34/73 (46%), Gaps = 9/73 (12%)
Query: 233 PISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPK 292
P+ FSP+ K LA+ + +W+ NL+H+ RG G I V + +
Sbjct: 456 PVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG----TGGIF-----EVCWNAR 506
Query: 293 DVNLASCAADGSV 305
+ + A+DGSV
Sbjct: 507 GDKVGASASDGSV 519
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,998,397
Number of Sequences: 37866
Number of extensions: 970936
Number of successful extensions: 6567
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 252
Number of HSP's successfully gapped in prelim test: 102
Number of HSP's that attempted gapping in prelim test: 2827
Number of HSP's gapped (non-prelim): 1743
length of query: 522
length of database: 18,247,518
effective HSP length: 107
effective length of query: 415
effective length of database: 14,195,856
effective search space: 5891280240
effective search space used: 5891280240
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.