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Search of human proteins with 119120907
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|119120907 par-3 partitioning defective 3 homolog B isoform a
[Homo sapiens]
(1104 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|119120907 par-3 partitioning defective 3 homolog B isoform a ... 2234 0.0
gi|119120897 par-3 partitioning defective 3 homolog B isoform b ... 1642 0.0
gi|119120903 par-3 partitioning defective 3 homolog B isoform c ... 1561 0.0
gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens] 538 e-152
gi|148746189 multiple PDZ domain protein [Homo sapiens] 107 5e-23
gi|112382257 InaD-like [Homo sapiens] 106 1e-22
gi|45827729 scribble isoform b [Homo sapiens] 91 6e-18
gi|45827731 scribble isoform a [Homo sapiens] 91 6e-18
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 86 3e-16
gi|24025688 ligand of numb-protein X 2 [Homo sapiens] 85 3e-16
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 83 1e-15
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 83 1e-15
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 83 1e-15
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 83 1e-15
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 82 2e-15
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 82 3e-15
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 82 3e-15
gi|148833504 interleukin 16 isoform 2 [Homo sapiens] 82 3e-15
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 81 6e-15
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 81 6e-15
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 81 6e-15
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 80 1e-14
gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens] 80 1e-14
gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens] 80 1e-14
gi|87196343 PDZ domain containing 2 [Homo sapiens] 75 4e-13
gi|218505835 membrane-associated guanylate kinase-related 3 iso... 73 2e-12
gi|27262655 interleukin 16 isoform 1 precursor [Homo sapiens] 71 5e-12
gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo sa... 71 6e-12
gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo sa... 71 6e-12
gi|155969695 membrane-associated guanylate kinase-related 3 iso... 69 2e-11
>gi|119120907 par-3 partitioning defective 3 homolog B isoform a [Homo
sapiens]
Length = 1104
Score = 2234 bits (5788), Expect = 0.0
Identities = 1104/1104 (100%), Positives = 1104/1104 (100%)
Query: 1 MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD 60
MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD
Sbjct: 1 MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD 60
Query: 61 PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG 120
PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG
Sbjct: 61 PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG 120
Query: 121 EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL 180
EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL
Sbjct: 121 EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL 180
Query: 181 NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS 240
NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS
Sbjct: 181 NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS 240
Query: 241 RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV 300
RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV
Sbjct: 241 RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV 300
Query: 301 IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG 360
IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG
Sbjct: 301 IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG 360
Query: 361 KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA 420
KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA
Sbjct: 361 KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA 420
Query: 421 AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKG 480
AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKG
Sbjct: 421 AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKG 480
Query: 481 EPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFK 540
EPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFK
Sbjct: 481 EPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFK 540
Query: 541 DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA 600
DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA
Sbjct: 541 DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA 600
Query: 601 ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPT 660
ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPT
Sbjct: 601 ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPT 660
Query: 661 PHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKV 720
PHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKV
Sbjct: 661 PHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKV 720
Query: 721 HSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNES 780
HSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNES
Sbjct: 721 HSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNES 780
Query: 781 FRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEK 840
FRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEK
Sbjct: 781 FRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEK 840
Query: 841 EKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGL 900
EKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGL
Sbjct: 841 EKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGL 900
Query: 901 REEELEKMKEERESGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWV 960
REEELEKMKEERESGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWV
Sbjct: 901 REEELEKMKEERESGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWV 960
Query: 961 PGRGPDGNAHNLRFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHP 1020
PGRGPDGNAHNLRFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHP
Sbjct: 961 PGRGPDGNAHNLRFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHP 1020
Query: 1021 PKGSYPRPTELRVADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPR 1080
PKGSYPRPTELRVADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPR
Sbjct: 1021 PKGSYPRPTELRVADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPR 1080
Query: 1081 GGSPDQYPYRTQDSRQKNPMTAAV 1104
GGSPDQYPYRTQDSRQKNPMTAAV
Sbjct: 1081 GGSPDQYPYRTQDSRQKNPMTAAV 1104
>gi|119120897 par-3 partitioning defective 3 homolog B isoform b [Homo
sapiens]
Length = 1143
Score = 1642 bits (4252), Expect = 0.0
Identities = 875/1054 (83%), Positives = 889/1054 (84%), Gaps = 108/1054 (10%)
Query: 1 MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD 60
MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD
Sbjct: 1 MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD 60
Query: 61 PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG 120
PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG
Sbjct: 61 PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG 120
Query: 121 EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL 180
EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL
Sbjct: 121 EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL 180
Query: 181 NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS 240
NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS
Sbjct: 181 NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS 240
Query: 241 RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV 300
RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV
Sbjct: 241 RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV 300
Query: 301 IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG 360
IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG
Sbjct: 301 IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG 360
Query: 361 KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA 420
KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA
Sbjct: 361 KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA 420
Query: 421 AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKG 480
AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPREL G
Sbjct: 421 AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELDG 480
Query: 481 EPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFK 540
+ +ND A G SL G
Sbjct: 481 -----------------RLRMNDQLIAVNGESLLG------------------------- 498
Query: 541 DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA 600
KSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA
Sbjct: 499 --------------------KSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA 538
Query: 601 ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPT 660
ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPT
Sbjct: 539 ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPT 598
Query: 661 PHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKV 720
PHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKV
Sbjct: 599 PHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKV 658
Query: 721 HSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNES 780
HSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNES
Sbjct: 659 HSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNES 718
Query: 781 FRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEK 840
FRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEK
Sbjct: 719 FRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEK 778
Query: 841 EKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGL 900
EKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGL
Sbjct: 779 EKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGL 838
Query: 901 REEELEKMKEERESGRPTGGSTDRIQKLRKEYYQARREGFPLY-----------EDDE-- 947
REEELEKMKEERE RI +E + + G Y +DDE
Sbjct: 839 REEELEKMKEERE----------RIGAKHQELREKQARGLLDYATGAIGSVYDMDDDEMD 888
Query: 948 -GRARPSEYDLLWVPGRGPDGNAHNLRFEGMERQYASLPRGGP-ADPVDYLPAAP----- 1000
AR + + R P +A+ R S PR GP P D P +P
Sbjct: 889 PNYARVNHF-------REPCTSANVFR-------SPSPPRAGPFGYPRDGHPLSPERDHL 934
Query: 1001 RGLYKERELPYYP--GAHPMHPPKGSYPRPTELR 1032
GLY + PY+P A P GS R +LR
Sbjct: 935 EGLYAKVNKPYHPLVPADSGRPTGGSTDRIQKLR 968
Score = 419 bits (1077), Expect = e-117
Identities = 191/192 (99%), Positives = 192/192 (100%)
Query: 913 ESGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDGNAHNL 972
+SGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDGNAHNL
Sbjct: 952 DSGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDGNAHNL 1011
Query: 973 RFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELR 1032
RFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELR
Sbjct: 1012 RFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELR 1071
Query: 1033 VADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQ 1092
VADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQ
Sbjct: 1072 VADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQ 1131
Query: 1093 DSRQKNPMTAAV 1104
DSRQKNPMTAAV
Sbjct: 1132 DSRQKNPMTAAV 1143
>gi|119120903 par-3 partitioning defective 3 homolog B isoform c [Homo
sapiens]
Length = 1136
Score = 1561 bits (4043), Expect = 0.0
Identities = 844/1054 (80%), Positives = 867/1054 (82%), Gaps = 115/1054 (10%)
Query: 1 MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD 60
MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD
Sbjct: 1 MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD 60
Query: 61 PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG 120
PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG
Sbjct: 61 PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG 120
Query: 121 EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL 180
EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL
Sbjct: 121 EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL 180
Query: 181 NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS 240
NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS
Sbjct: 181 NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS 240
Query: 241 RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV 300
RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV
Sbjct: 241 RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV 300
Query: 301 IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG 360
IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG
Sbjct: 301 IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG 360
Query: 361 KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA 420
KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA
Sbjct: 361 KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA 420
Query: 421 AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKG 480
AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKG
Sbjct: 421 AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKG 480
Query: 481 EPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFK 540
EPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFK
Sbjct: 481 EPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFK 540
Query: 541 DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA 600
DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA
Sbjct: 541 DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA 600
Query: 601 ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPT 660
ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPT
Sbjct: 601 ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPT 660
Query: 661 PHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKV 720
PHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKV
Sbjct: 661 PHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKV 720
Query: 721 HSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNES 780
HSLAGQKS+ GL SS H +G
Sbjct: 721 HSLAGQKSD----------GLSDKSS-----------------------HSGQG------ 741
Query: 781 FRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEK 840
L+ +S+ G L E +++ + K +K +K K
Sbjct: 742 ------------------ALNCESAPQGNSEL--EDMENKARKVKKTKEKEKKKEKGK-- 779
Query: 841 EKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGL 900
LKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGL
Sbjct: 780 --------LKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGL 831
Query: 901 REEELEKMKEERESGRPTGGSTDRIQKLRKEYYQARREGFPLY-----------EDDE-- 947
REEELEKMKEERE RI +E + + G Y +DDE
Sbjct: 832 REEELEKMKEERE----------RIGAKHQELREKQARGLLDYATGAIGSVYDMDDDEMD 881
Query: 948 -GRARPSEYDLLWVPGRGPDGNAHNLRFEGMERQYASLPRGGP-ADPVDYLPAAP----- 1000
AR + + R P +A+ R S PR GP P D P +P
Sbjct: 882 PNYARVNHF-------REPCTSANVFR-------SPSPPRAGPFGYPRDGHPLSPERDHL 927
Query: 1001 RGLYKERELPYYP--GAHPMHPPKGSYPRPTELR 1032
GLY + PY+P A P GS R +LR
Sbjct: 928 EGLYAKVNKPYHPLVPADSGRPTGGSTDRIQKLR 961
Score = 419 bits (1077), Expect = e-117
Identities = 191/192 (99%), Positives = 192/192 (100%)
Query: 913 ESGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDGNAHNL 972
+SGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDGNAHNL
Sbjct: 945 DSGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDGNAHNL 1004
Query: 973 RFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELR 1032
RFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELR
Sbjct: 1005 RFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELR 1064
Query: 1033 VADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQ 1092
VADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQ
Sbjct: 1065 VADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQ 1124
Query: 1093 DSRQKNPMTAAV 1104
DSRQKNPMTAAV
Sbjct: 1125 DSRQKNPMTAAV 1136
>gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]
Length = 1356
Score = 538 bits (1385), Expect = e-152
Identities = 413/1147 (36%), Positives = 568/1147 (49%), Gaps = 239/1147 (20%)
Query: 154 SASHPG-GQSLKLVVPDSTQNLEDR---EVLNGVQTELLTSPRTKDTLSDMTRTVEISGE 209
SASHP G+ L+ D ED E + T L P +L DM + VE+ +
Sbjct: 223 SASHPMVGKWLEKQEQDEDGTEEDNSRVEPVGHADTGLEHIPNF--SLDDMVKLVEVPND 280
Query: 210 GGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQ 269
GGPLGIHVVPF S+ GR LGL ++ +E +++ E LF EN+CIV+IN+ DL ++ F Q
Sbjct: 281 GGPLGIHVVPF-SARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQ 339
Query: 270 AQDVFRQAMKSPSVLLHVLPPQNREQYEK-SVIGSLNIFGNNDGVLKTKVPPPVHGKSGL 328
AQ +FRQAM++P + HV+P N+EQYE+ S N + + + +GL
Sbjct: 340 AQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGL 399
Query: 329 KT---ANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPL--------MGFGSNK 377
T A + D+ + L + P G PS+P+ +P G+ + K
Sbjct: 400 HTVQRAPRLNHPPEQIDSHSRLPHSAHPS----GKPPSAPASAPQNVFSTTVSSGYNTKK 455
Query: 378 NAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVN 437
K++ I LKKG EGLGF++ +RD +I G PI+VKNILP+GAAI+DGRL++GDR++EVN
Sbjct: 456 IGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVN 515
Query: 438 GRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETS----- 492
G D+ G++QEE+V++LRSTK T SL++ RQE F PREL EP + ET
Sbjct: 516 GVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDED 575
Query: 493 ---------EQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGR 543
E LTFE+PLNDSGSAGLGVS+KGN+S+E DLGIF+KSII+GGAA KDGR
Sbjct: 576 IVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGR 635
Query: 544 LRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRR------------ 591
LR+NDQLIAVNGESLLGK+N +AMETLRRSMS EGN RGMIQL++ RR
Sbjct: 636 LRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695
Query: 592 ---PERPMEDPAECGA--FSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLP 646
PE P+E + S + + + RN ++ +G + +P
Sbjct: 696 PPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNA-ALSRIMGESGKYQLSPTVNMP 754
Query: 647 NDGWAESE------VPP------SPTPHSALGL--------------GLEDYSHSSGVDS 680
D E +PP S + H +G D S S VD
Sbjct: 755 QDDTVIIEDDRLPVLPPHLSDQSSSSSHDDVGFVTADAGTWAKAAISDSADCSLSPDVDP 814
Query: 681 AVYFPDQHINFRSVTPAR--------QPESINLKASKSMDL-VPDESKVHSLAGQKSESP 731
+ F + +S++ R Q + + + SKSMDL + DE+K++++ QK+ SP
Sbjct: 815 VLAFQREGFGRQSMSEKRTKQFSDASQLDFVKTRKSKSMDLGIADETKLNTVDDQKAGSP 874
Query: 732 SKDFGPTLGLKKSSSLESLQTAVAEVRKN-DLPFHRPRPHMVRGRGCNESFRAAIDKSYD 790
S+D GP+LGLKKSSSLESLQTAVAEV N D+PFHRPRP ++RGRGCNESFRAAIDKSYD
Sbjct: 875 SRDVGPSLGLKKSSSLESLQTAVAEVTLNGDIPFHRPRPRIIRGRGCNESFRAAIDKSYD 934
Query: 791 GP----------------EEIEADGLSDKSSHSGQGALNCESAPQGNSELEDM-ENKARK 833
P EE G S+ S Q + + E GN E D + K K
Sbjct: 935 KPAVDDDDEGMETLEEDTEESSRSGRESVSTASDQPSHSLERQMNGNQEKGDKTDRKKDK 994
Query: 834 VKKTKEKEKKKEKGKLKVKE-------------KKRKEENEDPERKIK------------ 868
K K+K++ KEK K+K K+ K RK++ + KIK
Sbjct: 995 TGKEKKKDRDKEKDKMKAKKGMLKGLGDMFRFGKHRKDDKIEKTGKIKIQESFTSEEERI 1054
Query: 869 -----KKGFGAMLRFGKKKEDK----------------------GGKAEQKGTL------ 895
++ A R ++++ + GG + +G++
Sbjct: 1055 RMKQEQERIQAKTREFRERQARERDYAEIQDFHRTFGCDDELMYGGVSSYEGSMALNARP 1114
Query: 896 ---KHGGLREEELEKMKEER-------ESGRPTGGSTDRIQKLRKEYYQARREGFPLYED 945
+ G + + ++K+ R +S R T + DRIQ+LR+E+ QA+++ ED
Sbjct: 1115 QSPREGHMMDALYAQVKKPRNSKPSPVDSNRSTPSNHDRIQRLRQEFQQAKQD-----ED 1169
Query: 946 DEGRARPSEYDLLWVPGR-GPDGNAHNLRFEGM---------------ERQYASLPRGGP 989
E R R ++ W R H++ E +RQY+SLPR
Sbjct: 1170 VEDRRRTYSFEQPWPNARPATQSGRHSVSVEVQMQRQRQEERESSQQAQRQYSSLPRQSR 1229
Query: 990 ADPV---------DYLPAAPRGLYKERELPYYP----------GAHPMHPPKGSYPRPTE 1030
+ +Y P G +E P Y G H + +
Sbjct: 1230 KNASSVSQDSWEQNYSPG--EGFQSAKENPRYSSYQGSRNGYLGGHGFNA-RVMLETQEL 1286
Query: 1031 LRVADLRYPQHY---PPPPAPQH---------------KGPFRQDVPPSPPQHQRMPAYQ 1072
LR R Q PP P + KGPFRQDVPPSP Q R+ Q
Sbjct: 1287 LRQEQRRKEQQMKKQPPSEGPSNYDSYKKVQDPSYAPPKGPFRQDVPPSPSQVARLNRLQ 1346
Query: 1073 --ETGRP 1077
E GRP
Sbjct: 1347 TPEKGRP 1353
Score = 156 bits (395), Expect = 9e-38
Identities = 78/146 (53%), Positives = 102/146 (69%), Gaps = 3/146 (2%)
Query: 1 MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD 60
MKVTVCFGRT +VVPC +G ++V L QQA+ RY K K P YW+++H LE+ DGGILD
Sbjct: 1 MKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWIQVHRLEHGDGGILD 60
Query: 61 PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAA-QLAAFKP-- 117
DD+L DV +DKD+L+AVF+EQ+P H + S + QSP+ F +E+ ++AF+P
Sbjct: 61 LDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQ 120
Query: 118 IGGEIEVTPSALKLGTPLLVRRSSDP 143
EIEVTPS L+ PL VRRSSDP
Sbjct: 121 ATSEIEVTPSVLRANMPLHVRRSSDP 146
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 107 bits (268), Expect = 5e-23
Identities = 139/583 (23%), Positives = 239/583 (40%), Gaps = 93/583 (15%)
Query: 65 LADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGGEIEV 124
L + ++D L V + H + + G A + E+ PI I +
Sbjct: 1493 LGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGY----PIEKFISL 1548
Query: 125 TPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVLNGVQ 184
+A K+ L + + P+ ++ S L+VP S E + N +
Sbjct: 1549 LKTA-KMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSP-EPESIRNTSR 1606
Query: 185 TE----LLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS 240
+ + P T + T+EIS LG+ +V +L G I+ I + +
Sbjct: 1607 SSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAII---IHEVYEEG 1663
Query: 241 RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLH--VLPPQNREQYEK 298
+ ++G + I+++N +DL T +A +V RQ + + L+ P + E +
Sbjct: 1664 AACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDT 1723
Query: 299 SVIG---------SLNIFG--NNDGVLKTKVPPPVHGKSGLKTAN-----------LTGT 336
I L+I G N+ GV + + K G+ A+ + G
Sbjct: 1724 LTIELQKKPGKGLGLSIVGKRNDTGVFVSDIV-----KGGIADADGRLMQGDQILMVNGE 1778
Query: 337 D--SPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKI------DLKK 388
D + +A A+L + + S S S + S KNA +I ++KK
Sbjct: 1779 DVRNATQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKK 1838
Query: 389 GP-EGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQE 447
GP + LG ++ S G PIF+ + P G A + +L+ GDRI+ + G G T
Sbjct: 1839 GPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHT 1898
Query: 448 ELVAMLRSTK--------QGETASLVIARQE-------------GHFLPRELKGEPDCCA 486
+ V +L++ G S+V Q+ + ++ G P C +
Sbjct: 1899 QAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKS 1958
Query: 487 LSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRM 546
++LE G GLG S+ G G DL I++K++ GAA +DGRL+
Sbjct: 1959 ITLER-------------GPDGLGFSIVGGYGSPHG-DLPIYVKTVFAKGAASEDGRLKR 2004
Query: 547 NDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVIL 589
DQ+IAVNG+SL G ++ EA+ L+R+ +G + L++L
Sbjct: 2005 GDQIIAVNGQSLEGVTHEEAVAILKRT-------KGTVTLMVL 2040
Score = 106 bits (264), Expect = 1e-22
Identities = 98/408 (24%), Positives = 182/408 (44%), Gaps = 63/408 (15%)
Query: 167 VPDSTQNLEDREVLNGVQTELLTSPRTKDTLS-DMTRTVEISGEGGPLGIHVVPFFSSLS 225
+P +++NL+++E + + TS D S + +E+ + G LGI + S
Sbjct: 1450 LPSNSENLQNKET----EPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAI-----SEE 1500
Query: 226 GRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLL 285
+ G+ I+ + ++ + +G + I+ +++ +V + + + A + + +
Sbjct: 1501 DTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI 1560
Query: 286 HVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASA 345
H P + Q S G+ + K+ ++ + + SPE ++
Sbjct: 1561 HAENPDS--QAVPSAAGAAS----------------GEKKNSSQSLMVPQSGSPEPESIR 1602
Query: 346 SLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIH 405
+ ++ +P + S P+ P++ + I++ KG GLG ++V ++
Sbjct: 1603 NTSRSSTPAI-----FASDPATCPIIP------GCETTIEISKGRTGLGLSIVGGSDTLL 1651
Query: 406 GPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLV 465
G I + + +GAA KDGRL +GD+ILEVNG D+ T +E + +LR T Q L
Sbjct: 1652 GA--IIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQ--RVRLT 1707
Query: 466 IARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDL 525
+ R E + K E C L++E L GLG+S+ G ++ D
Sbjct: 1708 LYRDEAPY-----KEEEVCDTLTIE----------LQKKPGKGLGLSIVGKRN-----DT 1747
Query: 526 GIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 573
G+F+ I+ GG A DGRL DQ++ VNGE + + L+ S
Sbjct: 1748 GVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVS 1795
Score = 92.8 bits (229), Expect = 2e-18
Identities = 86/278 (30%), Positives = 127/278 (45%), Gaps = 48/278 (17%)
Query: 343 ASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKN--AKKIKIDLKKGPEGLGFTVVTR 400
A SL Q SP V R SPS + + SN I+L GLGF ++
Sbjct: 221 ARGSLPQLVSPIVSR------SPSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGG 274
Query: 401 DSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGE 460
++ + VK ILP G A + GRL SGD IL++ D+ G + E++ +LR G
Sbjct: 275 KAT-----GVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQC--GN 327
Query: 461 TASLVIARQEGHFLPRELKGEPDCCALSLETS-----------------EQLTFEIPLND 503
L+IAR E + P ++L +S E TF++ L
Sbjct: 328 RVKLMIARGA-----IEERTAPTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTK 382
Query: 504 SGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSN 563
+ GLG+++ G + GIF+KSI A DGR+++ DQ+IAV+G +L G +N
Sbjct: 383 NVQ-GLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTN 441
Query: 564 HEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAE 601
+A+E LR + Q V+L R M+ AE
Sbjct: 442 QQAVEVLRHTG----------QTVLLTLMRRGMKQEAE 469
Score = 86.7 bits (213), Expect = 1e-16
Identities = 116/436 (26%), Positives = 189/436 (43%), Gaps = 70/436 (16%)
Query: 174 LEDREVLNGVQTELLTSPRTKDTLSDMTRTVEISGEGGP-LGIHVVP---FFSSLS-GRI 228
L +RE G ++EL T + + R VE+ E LGI +V S LS G +
Sbjct: 1125 LPEREEGEGEESEL---QNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEV 1181
Query: 229 L-GLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLL-- 285
+ G+FI+ + ++S + + G + IV+++ +DL D + QA + R+A +P V +
Sbjct: 1182 MRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKA-GNPVVFMVQ 1240
Query: 286 --------HVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTD 337
LP Y K S N F ++ + K P +S + A L
Sbjct: 1241 SIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPS--QSESEPEKAPLCSVP 1298
Query: 338 SPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG-SNKNAKKI---------KIDLK 387
P A A + + + + S + FG S KN ++ I+L+
Sbjct: 1299 PPPPSAFAEMGSDHT----QSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELE 1354
Query: 388 KGPEGLGFTVV-TRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQ 446
KG GLG ++ +D S +F+ I P GAA KDGRLQ D +LE+NG+ + GR+
Sbjct: 1355 KGHSGLGLSLAGNKDRSRMS---VFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSH 1411
Query: 447 EELVAMLR-----------STKQGETASLVIARQEGHFLP------RELKGEPDC----C 485
+ ++++ K V LP + + EP
Sbjct: 1412 QNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDA 1471
Query: 486 ALSLETSEQLT-FEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRL 544
A+ L + + + E+P D G G+ +S E T G+ IKS+ G A DGRL
Sbjct: 1472 AVDLSSFKNVQHLELP-KDQGGLGIAIS-------EEDTLSGVIIKSLTEHGVAATDGRL 1523
Query: 545 RMNDQLIAVNGESLLG 560
++ DQ++AV+ E ++G
Sbjct: 1524 KVGDQILAVDDEIVVG 1539
Score = 82.8 bits (203), Expect = 2e-15
Identities = 81/308 (26%), Positives = 134/308 (43%), Gaps = 26/308 (8%)
Query: 271 QDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKT 330
+ V + + S + L Q ++Q + + NI + L V P + +S L +
Sbjct: 37 KSVLQSPLFSQILSLQTSVQQLKDQVNIATSATSNIEYAHVPHLSPAVIPTLQNESFLLS 96
Query: 331 ANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGP 390
N + +L+ P +P + GKP+ L+ + ++ LK
Sbjct: 97 PN-----------NGNLEALTGPGIPHINGKPACDEFDQLIKNMAQGRHVEVFELLKPPS 145
Query: 391 EGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGR-TQEEL 449
GLGF+VV S G IFV+ I A +DGRL+ D+IL +NG+ + T ++
Sbjct: 146 GGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQA 205
Query: 450 VAMLRSTKQGETASLVIARQE-----GHFLPRELKGEPDCCALSLETSEQLTFEIPLNDS 504
+++L+ K +T LVIAR + R A S Q I L +
Sbjct: 206 ISILQKAK--DTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVND 263
Query: 505 GSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNH 564
GS GLG + G K+ G+ +K+I+ GG A + GRL D ++ + L G S+
Sbjct: 264 GS-GLGFGIIGGKA------TGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSE 316
Query: 565 EAMETLRR 572
+ + LR+
Sbjct: 317 QVAQVLRQ 324
Score = 80.5 bits (197), Expect = 8e-15
Identities = 111/486 (22%), Positives = 189/486 (38%), Gaps = 85/486 (17%)
Query: 186 ELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKRE 245
EL T+ T VE++ LGI + + G+F++ I +S + +
Sbjct: 360 ELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHD 419
Query: 246 GLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYE----KSVI 301
G + I+ ++ +L T QA +V R +VLL ++ +++ E + V
Sbjct: 420 GRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHT--GQTVLLTLMRRGMKQEAELMSREDVT 477
Query: 302 GSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTD-------SPETDASASLQQNKSPR 354
++ N ++K S + N+ T+ S E + Q+ ++
Sbjct: 478 KDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAAL 537
Query: 355 VPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKN 414
+ + +MG N + + + K E G + + H F+++
Sbjct: 538 LTKW---------QRIMGI----NYEIVVAHVSKFSENSGLGISLEATVGHH----FIRS 580
Query: 415 ILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRS----------------TKQ 458
+LP+G G+L SGD +LEVNG + G +++V +L+ T Q
Sbjct: 581 VLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQ 640
Query: 459 GETASLVIARQE---------GHFLPRELKGEPDCCALSLETSEQLTFEI--PLN----- 502
E SL + E G F+ +P L++ + Q T E+ PL
Sbjct: 641 SELDSLDLCDIELTEKPHVDLGEFIGSSETEDP---VLAMTDAGQSTEEVQAPLAMWEAG 697
Query: 503 ------DSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGE 556
+ GS GLG S+ + I I+S++ GG A KDGRL D+L+ VN
Sbjct: 698 IQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDV 757
Query: 557 SLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPER------------PMEDPAECGA 604
+L S EA+E L+ + S G +R + + PE P E G
Sbjct: 758 NLENSSLEEAVEALKGAPS--GTVRIGVAKPLPLSPEEGYVSAKEDSFLYPPHSCEEAGL 815
Query: 605 FSKPCF 610
KP F
Sbjct: 816 ADKPLF 821
Score = 71.6 bits (174), Expect = 4e-12
Identities = 118/503 (23%), Positives = 194/503 (38%), Gaps = 129/503 (25%)
Query: 211 GPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDK-TFAQ 269
G LG VV S G LG+F++ I++ S + R+G E + I+ IN L T Q
Sbjct: 146 GGLGFSVVGLRSENRGE-LGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQ 204
Query: 270 AQDVFRQA---------------------MKSPS----VLLHVLPP--QNREQYEKSVIG 302
A + ++A +SPS + H P Q+ E E G
Sbjct: 205 AISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVNDG 264
Query: 303 SLNIFGNNDG-----VLKTKVPPPV---HGK--SG-----LKTANLTGTDSPETD----- 342
S FG G ++KT +P V HG+ SG + +L G S +
Sbjct: 265 SGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQ 324
Query: 343 ---------ASASLQQNKSPR---VPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGP 390
A ++++ +P + S+P L + ++ ++L K
Sbjct: 325 CGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTKNV 384
Query: 391 EGLGFTVV--TRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEE 448
+GLG T+ D + P IFVK+I A DGR+Q GD+I+ V+G ++ G T ++
Sbjct: 385 QGLGITIAGYIGDKKLE-PSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQ 443
Query: 449 LVAMLRSTKQGETASLVIAR---------------------------------------- 468
V +LR T G+T L + R
Sbjct: 444 AVEVLRHT--GQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKENYEKDEDFL 501
Query: 469 ---QEGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLK------GNKSR 519
+ + LP E +G P A E + E L +G++ + S
Sbjct: 502 SSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSE 561
Query: 520 ETGTDLGI-------FIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRR 572
+G + + FI+S++ G G+L D+L+ VNG +LLG+ NH+ + + +
Sbjct: 562 NSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGE-NHQDVVNILK 620
Query: 573 SMSMEGNIRGMIQLVILRRPERP 595
+ +E + +V RR P
Sbjct: 621 ELPIE------VTMVCCRRTVPP 637
Score = 62.8 bits (151), Expect = 2e-09
Identities = 65/259 (25%), Positives = 114/259 (44%), Gaps = 46/259 (17%)
Query: 376 NKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILE 435
+K + + I++ KG LG TV + + V++I+ GA +DGR+ GD IL
Sbjct: 1001 SKESFERTINIAKGNSSLGMTVSANKDGLG----MIVRSIIHGGAISRDGRIAIGDCILS 1056
Query: 436 VNGRDVTGRTQEELVAMLRS--------------TKQGETASLVIARQEGHF-------- 473
+N T + AMLR + E + + +Q G
Sbjct: 1057 INEESTISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSS 1116
Query: 474 --------LPRELKGEPDCCAL--SLETSEQLTFEIPLNDSGSAGLGVSLKGNK---SRE 520
LP +GE + L + ++ + L S LG+S+ G + SR
Sbjct: 1117 YTGRDIPELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRL 1176
Query: 521 TGTDL--GIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEG 578
+ ++ GIFIK ++ A K+G L+ D+++ V+G L S+ +A+E +R++ G
Sbjct: 1177 SNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKA----G 1232
Query: 579 N-IRGMIQLVILRRPERPM 596
N + M+Q +I R + P+
Sbjct: 1233 NPVVFMVQSIINRPRKSPL 1251
Score = 62.4 bits (150), Expect = 2e-09
Identities = 66/260 (25%), Positives = 117/260 (45%), Gaps = 44/260 (16%)
Query: 202 RTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVD 261
RT+ I+ LG+ V S + LG+ +R I R+G +CI+ IN
Sbjct: 1007 RTINIAKGNSSLGMTV-----SANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEES 1061
Query: 262 LVDKTFAQAQDVFRQ-AMKSPSVLLHVLPPQNREQYEKSV------IGSLNIFGNNDGVL 314
+ T AQA+ + R+ ++ P + + +P ++ E+++ S+ + +L+IF + G
Sbjct: 1062 TISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRD 1121
Query: 315 KTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG 374
++P G+ + E +A N+ PR L +PS
Sbjct: 1122 IPELPEREEGEG----------EESELQNTAYSNWNQ-PRRVELWREPS----------- 1159
Query: 375 SNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRIL 434
K + I + G G+G +R S+ IF+K++L A K+G L+ GDRI+
Sbjct: 1160 -----KSLGISI-VGGRGMG----SRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIV 1209
Query: 435 EVNGRDVTGRTQEELVAMLR 454
EV+G D+ + E+ V +R
Sbjct: 1210 EVDGMDLRDASHEQAVEAIR 1229
Score = 57.8 bits (138), Expect = 6e-08
Identities = 29/69 (42%), Positives = 44/69 (63%), Gaps = 3/69 (4%)
Query: 503 DSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKS 562
+ G +GLG+SL GNK R + +FI I GAA KDGRL++ D+L+ +NG+ L G+S
Sbjct: 1354 EKGHSGLGLSLAGNKDRSR---MSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRS 1410
Query: 563 NHEAMETLR 571
+ A ++
Sbjct: 1411 HQNASSIIK 1419
Score = 56.2 bits (134), Expect = 2e-07
Identities = 32/85 (37%), Positives = 51/85 (60%), Gaps = 7/85 (8%)
Query: 506 SAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHE 565
S GLG S+ G +S G +LGIF++ I G A +DGRL+ DQ++A+NG++L H+
Sbjct: 145 SGGLGFSVVGLRSENRG-ELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQ 203
Query: 566 AMETLRRSMSMEGNIRGMIQLVILR 590
+++S+ + +QLVI R
Sbjct: 204 ------QAISILQKAKDTVQLVIAR 222
Score = 56.2 bits (134), Expect = 2e-07
Identities = 30/85 (35%), Positives = 53/85 (62%), Gaps = 6/85 (7%)
Query: 489 LETSEQLTFEIPLNDS-GSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMN 547
L+ + +FE +N + G++ LG+++ NK LG+ ++SIIHGGA +DGR+ +
Sbjct: 997 LQNVSKESFERTINIAKGNSSLGMTVSANKD-----GLGMIVRSIIHGGAISRDGRIAIG 1051
Query: 548 DQLIAVNGESLLGKSNHEAMETLRR 572
D ++++N ES + +N +A LRR
Sbjct: 1052 DCILSINEESTISVTNAQARAMLRR 1076
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 106 bits (265), Expect = 1e-22
Identities = 106/412 (25%), Positives = 180/412 (43%), Gaps = 95/412 (23%)
Query: 211 GPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQA 270
G LG VV S G++ +F++ ++ S + R+ EN+ I+ IN+ L D+ +
Sbjct: 143 GGLGFSVVALRSQNLGKV-DIFVKDVQPGSVADRDQRLKENDQILAINHTPL-DQNISHQ 200
Query: 271 QDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKT 330
Q + LL + GSL + + PVH KS +
Sbjct: 201 QAI---------ALL------------QQTTGSLRLIVARE---------PVHTKSST-S 229
Query: 331 ANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGP 390
++L T PET +++ ++L
Sbjct: 230 SSLNDTTLPETVCWGHVEE----------------------------------VELINDG 255
Query: 391 EGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELV 450
GLGF +V +S + V+ I+P G A +DGRLQ+GD IL++ G +V G T E++
Sbjct: 256 SGLGFGIVGGKTS-----GVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVA 310
Query: 451 AMLRSTKQGETASLVIARQEGHFL------PRELKGEPDCCALSLETSEQLTFE---IPL 501
+LR+ G + +++AR + P L A S+ FE + L
Sbjct: 311 QVLRNC--GNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSSLFETYNVEL 368
Query: 502 NDSGSAGLGVSLKGNK-SRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLG 560
LG+ + G + TG GI++KSII G AA+ +G +++ND+++AV+G ++ G
Sbjct: 369 VRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQG 428
Query: 561 KSNHEAMETLRRSMSMEGNIRGMIQLVILRR----PERPMEDPAECGAFSKP 608
+NH+ +E LR N ++ L ++RR P+E P++ G +P
Sbjct: 429 FANHDVVEVLR-------NAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEP 473
Score = 103 bits (256), Expect = 1e-21
Identities = 107/454 (23%), Positives = 189/454 (41%), Gaps = 73/454 (16%)
Query: 164 KLVVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMT---RTVEISGEGGPLGIHVVPF 220
K + DS +N E+ + T + + +D+ +E+ + LG+ +
Sbjct: 1206 KALTDDSDENEEE---------DAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLA-- 1254
Query: 221 FSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKS 280
+ + +F+ GI + +G + +++INN L ++ A + + A
Sbjct: 1255 -GNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSK 1313
Query: 281 PSVL----------LHVLP---PQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSG 327
++ + V P P + + G+ I DG ++ + +S
Sbjct: 1314 VKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESESF 1373
Query: 328 LKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNA-------- 379
+ T S S Q+ P P + + GF + +
Sbjct: 1374 KLAVSQMKQQKYPTKVSFSSQE--IPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIV 1431
Query: 380 --KKIKIDLKKGPEGLGFTVVT-RDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEV 436
+++ I++ KG GLG ++V +D+ ++ I + + +GAA +DGRL +GD+ILEV
Sbjct: 1432 PGQEMIIEISKGRSGLGLSIVGGKDTPLNA---IVIHEVYEEGAAARDGRLWAGDQILEV 1488
Query: 437 NGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLT 496
NG D+ + EE + LR T Q LV+ R E H+ E +LE
Sbjct: 1489 NGVDLRNSSHEEAITALRQTPQ--KVRLVVYRDEAHYRDEE----------NLE-----I 1531
Query: 497 FEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGE 556
F + L GLG+S+ G ++ G+FI I+ GGAA DGRL DQ+++VNGE
Sbjct: 1532 FPVDLQKKAGRGLGLSIVGKRNGS-----GVFISDIVKGGAADLDGRLIQGDQILSVNGE 1586
Query: 557 SLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILR 590
+ S L+ + +G++QL I R
Sbjct: 1587 DMRNASQETVATILKCA-------QGLVQLEIGR 1613
Score = 77.8 bits (190), Expect = 5e-14
Identities = 69/271 (25%), Positives = 124/271 (45%), Gaps = 36/271 (13%)
Query: 333 LTGTDSPETDASASLQQNKS------PRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDL 386
L TD T+ + N S P P+LG + + S + + + I I+
Sbjct: 83 LVFTDGSITNGNVHRPSNNSTVSGLFPWTPKLGNEDFN---SVIQQMAQGRQIEYIDIE- 138
Query: 387 KKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGR-T 445
+ GLGF+VV S G IFVK++ P A +D RL+ D+IL +N + +
Sbjct: 139 RPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNIS 198
Query: 446 QEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTF----EIPL 501
++ +A+L+ T + L++AR+ P K E + + E+ L
Sbjct: 199 HQQAIALLQQTT--GSLRLIVARE-----PVHTKSSTSSSLNDTTLPETVCWGHVEEVEL 251
Query: 502 NDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGK 561
+ GS GLG + G K+ G+ +++I+ GG A +DGRL+ D ++ + G ++ G
Sbjct: 252 INDGS-GLGFGIVGGKTS------GVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGM 304
Query: 562 SNHEAMETLRRSMSMEGNIRGMIQLVILRRP 592
++ + + LR N +++++ R P
Sbjct: 305 TSEQVAQVLR-------NCGNSVRMLVARDP 328
Score = 74.3 bits (181), Expect = 6e-13
Identities = 68/235 (28%), Positives = 108/235 (45%), Gaps = 41/235 (17%)
Query: 373 FGSNKNAKKIKIDL-KKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGD 431
+ +N + +DL KK GLG ++V + + G G +F+ +I+ GAA DGRL GD
Sbjct: 1523 YRDEENLEIFPVDLQKKAGRGLGLSIVGKRN---GSG-VFISDIVKGGAADLDGRLIQGD 1578
Query: 432 RILEVNGRDVTGRTQEELVAML----------------------RSTKQGETASLVIARQ 469
+IL VNG D+ +QE + +L R+T Q S A
Sbjct: 1579 QILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHS 1638
Query: 470 EGH--FLP-----RELKGEPDCCALSLETS----EQLTFEIPLNDSGSAGLGVSLKGNKS 518
H F P + L G S + S E T EI N S LG+S+ G +
Sbjct: 1639 SCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEI--NRELSDALGISIAGGRG 1696
Query: 519 RETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 573
G D+ +FI I G A + +L++ D+++++NG+ L G S+ + + L+ +
Sbjct: 1697 SPLG-DIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNA 1750
Score = 58.5 bits (140), Expect = 3e-08
Identities = 60/249 (24%), Positives = 102/249 (40%), Gaps = 60/249 (24%)
Query: 394 GFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAML 453
G TV+ R + IF+K +L A K L++GD+ILEV+G D+ + E V +
Sbjct: 1086 GQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAI 1145
Query: 454 RST------------------------------KQGETASLVIARQEGHFLPRELKGEPD 483
++ Q + +++G P +K P
Sbjct: 1146 KNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGT-APPPMKLPPP 1204
Query: 484 CCALSLETSE-------------QLTFEIPLN------DSGSAGLGVSLKGNKSRETGTD 524
AL+ ++ E Q ++P + GLG+SL GNK R
Sbjct: 1205 YKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSR--- 1261
Query: 525 LGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMI 584
+ IF+ I G A DGR+R+ D+L+ +N + L G+S+ A ++ + S +
Sbjct: 1262 MSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPS-------KV 1314
Query: 585 QLVILRRPE 593
+LV +R +
Sbjct: 1315 KLVFIRNED 1323
Score = 55.8 bits (133), Expect = 2e-07
Identities = 92/428 (21%), Positives = 166/428 (38%), Gaps = 70/428 (16%)
Query: 191 PRTKDTLSDMTRTVEISGEGGPLGIHVVPFF-SSLSGRILGLFIRGIEDNSRSKREGLFH 249
P + +L + + +G LGI +V + +S +G G++++ I S + G
Sbjct: 354 PGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQ 413
Query: 250 ENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGN 309
N+ IV ++ V++ + FA V + +++ ++H+ + + S + + G
Sbjct: 414 VNDKIVAVDGVNI--QGFANHDVV--EVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGT 469
Query: 310 NDGVLKTKVPPPVHGKSGLKT-ANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLS 368
V++ PP + ++T N+ G D + +L+ + + +L P SP
Sbjct: 470 ---VVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSP--- 523
Query: 369 PLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPI------------------ 410
+N K + + GP+ V T D+ I +
Sbjct: 524 --------ENELKSRWENLLGPD-YEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEV 574
Query: 411 -------FVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETAS 463
++ +I+ G G LQ D +LEVNG + G+++ E V+ L+ T
Sbjct: 575 DSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFT-- 632
Query: 464 LVIARQEGHFLPRELKGEPDCCALSL---ETSEQLTFEIPLNDSGS-------------- 506
LV R+ F EP SL E + +D G
Sbjct: 633 LVCCRR--LFDDEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELV 690
Query: 507 ---AGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSN 563
GLG S+ + T I I+S++ G A + G L D+L++VN L S
Sbjct: 691 KDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSL 750
Query: 564 HEAMETLR 571
EA+E L+
Sbjct: 751 AEAVEILK 758
Score = 55.8 bits (133), Expect = 2e-07
Identities = 74/319 (23%), Positives = 136/319 (42%), Gaps = 58/319 (18%)
Query: 171 TQNLEDREVLNGVQTELLTS---PRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGR 227
T L +RE G +T + PR + + ++ IS GG I + L G
Sbjct: 1043 TCELPEREEGEGEETPNFSHWGPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKG- 1101
Query: 228 ILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHV 287
+FI+ + ++S + + + I++++ VDL + + ++A + + A +P V
Sbjct: 1102 ---IFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNA-GNPVVF--- 1154
Query: 288 LPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASL 347
++ SL+ +V P VH K+ +TG + +T
Sbjct: 1155 ------------IVQSLSS--------TPRVIPNVHNKAN----KITGNQNQDTQEKKEK 1190
Query: 348 QQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNA---KKIK------------IDLKKGPEG 392
+Q +P P + P +L+ ++A +KI+ I+L+K G
Sbjct: 1191 RQGTAP--PPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNG 1248
Query: 393 LGFTVV-TRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVA 451
LG ++ +D S IFV I P+G A DGR++ GD +LE+N + + GR+ + A
Sbjct: 1249 LGLSLAGNKDRSRMS---IFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASA 1305
Query: 452 MLRSTKQGETASLVIARQE 470
++++ LV R E
Sbjct: 1306 IIKTAP--SKVKLVFIRNE 1322
Score = 40.0 bits (92), Expect = 0.012
Identities = 23/73 (31%), Positives = 40/73 (54%), Gaps = 5/73 (6%)
Query: 506 SAGLGVSLKGN----KSRETGTDL-GIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLG 560
+ LG+S+ G K + G +L GIFIK ++ A K L+ D+++ V+G L
Sbjct: 1076 NVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQN 1135
Query: 561 KSNHEAMETLRRS 573
S+ EA+E ++ +
Sbjct: 1136 ASHSEAVEAIKNA 1148
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 90.9 bits (224), Expect = 6e-18
Identities = 114/438 (26%), Positives = 180/438 (41%), Gaps = 102/438 (23%)
Query: 147 PPADTQPSASHPGGQSLKLVVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMTRTVEI 206
P D P GG L L+ P+S L R V ++E R +
Sbjct: 830 PEDDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSE---------------RGLGF 874
Query: 207 SGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKT 266
S GG P+ + +G +F+ I + + R G + ++ IN VD+ +
Sbjct: 875 SIAGGKGS---TPYRAGDAG----IFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEAR 927
Query: 267 FAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKS 326
A + A + ++LL E+ G L PP
Sbjct: 928 HDHAVSLLTAASPTIALLL-----------EREAGGPL---------------PP----- 956
Query: 327 GLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKN---AKKIK 383
+ L + P + + +P VP L PSL+P + + + ++I+
Sbjct: 957 ----SPLPHSSPPTAAVATTSITTATPGVPGL------PSLAPSLLAAALEGPYPVEEIR 1006
Query: 384 IDLKKGPEGLGFTVVTRDSS----IHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGR 439
+ GP GL + SS + PG +F+ +LP+G A + G L+ GDRIL VNG+
Sbjct: 1007 LPRAGGPLGLSIVGGSDHSSHPFGVQEPG-VFISKVLPRGLAARSG-LRVGDRILAVNGQ 1064
Query: 440 DVTGRTQEELV-AMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFE 498
DV T +E V A+LR + SL++ R P L+ E
Sbjct: 1065 DVRDATHQEAVSALLRPCLE---LSLLVRRDPA---PPGLR------------------E 1100
Query: 499 IPLNDSGSAGLGVSLKGNKSRETG-----TDLGIFIKSIIHGGAAFKDGRLRMNDQLIAV 553
+ + + LG+S++G G TD GIFI + GAA +DGRLR+ +L+ V
Sbjct: 1101 LCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEV 1160
Query: 554 NGESLLGKSNHEAMETLR 571
N +SLLG ++ EA++ LR
Sbjct: 1161 NQQSLLGLTHGEAVQLLR 1178
Score = 57.0 bits (136), Expect = 1e-07
Identities = 52/212 (24%), Positives = 89/212 (41%), Gaps = 22/212 (10%)
Query: 380 KKIKIDLKKGPEGLGFTVVTRDSSIHGPGP---IFVKNILPKGAAIKDGRLQSGDRILEV 436
+++ + + + GLG ++ S G IF+ + +G A + G ++ GD++LEV
Sbjct: 725 EELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEV 783
Query: 437 NGRDVTGRTQEELVAMLRST--------------KQGETASLVIARQEGHFLPRELKGEP 482
NG + G E V LR + ++ R E + PRE +G
Sbjct: 784 NGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGG 843
Query: 483 DCCALSLETSEQLTFE--IPLNDSGSAGLGVSLKGNKSRET--GTDLGIFIKSIIHGGAA 538
L S + + GLG S+ G K D GIF+ I GGAA
Sbjct: 844 LRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAA 903
Query: 539 FKDGRLRMNDQLIAVNGESLLGKSNHEAMETL 570
+ G L++ D+++++NG + + A+ L
Sbjct: 904 HRAGTLQVGDRVLSINGVDVTEARHDHAVSLL 935
Score = 53.1 bits (126), Expect = 1e-06
Identities = 44/130 (33%), Positives = 62/130 (47%), Gaps = 11/130 (8%)
Query: 444 RTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLND 503
R +EE + K+G S + L EP + E+LT I L
Sbjct: 681 RAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEP-----ARIEEEELTLTI-LRQ 734
Query: 504 SGSAGLGVSLKGNKSRET--GTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGK 561
+G GLG+S+ G K G D GIFI + G A + G +R+ D+L+ VNG +L G
Sbjct: 735 TG--GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGA 791
Query: 562 SNHEAMETLR 571
+HEA+E LR
Sbjct: 792 EHHEAVEALR 801
Score = 48.1 bits (113), Expect = 4e-05
Identities = 25/57 (43%), Positives = 38/57 (66%), Gaps = 2/57 (3%)
Query: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVI 466
IF+ + P GAA +DGRL+ G R+LEVN + + G T E V +LRS G+T ++++
Sbjct: 1134 IFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSV--GDTLTVLV 1188
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 90.9 bits (224), Expect = 6e-18
Identities = 114/438 (26%), Positives = 180/438 (41%), Gaps = 102/438 (23%)
Query: 147 PPADTQPSASHPGGQSLKLVVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMTRTVEI 206
P D P GG L L+ P+S L R V ++E R +
Sbjct: 830 PEDDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSE---------------RGLGF 874
Query: 207 SGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKT 266
S GG P+ + +G +F+ I + + R G + ++ IN VD+ +
Sbjct: 875 SIAGGKGS---TPYRAGDAG----IFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEAR 927
Query: 267 FAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKS 326
A + A + ++LL E+ G L PP
Sbjct: 928 HDHAVSLLTAASPTIALLL-----------EREAGGPL---------------PP----- 956
Query: 327 GLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKN---AKKIK 383
+ L + P + + +P VP L PSL+P + + + ++I+
Sbjct: 957 ----SPLPHSSPPTAAVATTSITTATPGVPGL------PSLAPSLLAAALEGPYPVEEIR 1006
Query: 384 IDLKKGPEGLGFTVVTRDSS----IHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGR 439
+ GP GL + SS + PG +F+ +LP+G A + G L+ GDRIL VNG+
Sbjct: 1007 LPRAGGPLGLSIVGGSDHSSHPFGVQEPG-VFISKVLPRGLAARSG-LRVGDRILAVNGQ 1064
Query: 440 DVTGRTQEELV-AMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFE 498
DV T +E V A+LR + SL++ R P L+ E
Sbjct: 1065 DVRDATHQEAVSALLRPCLE---LSLLVRRDPA---PPGLR------------------E 1100
Query: 499 IPLNDSGSAGLGVSLKGNKSRETG-----TDLGIFIKSIIHGGAAFKDGRLRMNDQLIAV 553
+ + + LG+S++G G TD GIFI + GAA +DGRLR+ +L+ V
Sbjct: 1101 LCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEV 1160
Query: 554 NGESLLGKSNHEAMETLR 571
N +SLLG ++ EA++ LR
Sbjct: 1161 NQQSLLGLTHGEAVQLLR 1178
Score = 57.0 bits (136), Expect = 1e-07
Identities = 52/212 (24%), Positives = 89/212 (41%), Gaps = 22/212 (10%)
Query: 380 KKIKIDLKKGPEGLGFTVVTRDSSIHGPGP---IFVKNILPKGAAIKDGRLQSGDRILEV 436
+++ + + + GLG ++ S G IF+ + +G A + G ++ GD++LEV
Sbjct: 725 EELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEV 783
Query: 437 NGRDVTGRTQEELVAMLRST--------------KQGETASLVIARQEGHFLPRELKGEP 482
NG + G E V LR + ++ R E + PRE +G
Sbjct: 784 NGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGG 843
Query: 483 DCCALSLETSEQLTFE--IPLNDSGSAGLGVSLKGNKSRET--GTDLGIFIKSIIHGGAA 538
L S + + GLG S+ G K D GIF+ I GGAA
Sbjct: 844 LRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAA 903
Query: 539 FKDGRLRMNDQLIAVNGESLLGKSNHEAMETL 570
+ G L++ D+++++NG + + A+ L
Sbjct: 904 HRAGTLQVGDRVLSINGVDVTEARHDHAVSLL 935
Score = 53.1 bits (126), Expect = 1e-06
Identities = 44/130 (33%), Positives = 62/130 (47%), Gaps = 11/130 (8%)
Query: 444 RTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLND 503
R +EE + K+G S + L EP + E+LT I L
Sbjct: 681 RAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEP-----ARIEEEELTLTI-LRQ 734
Query: 504 SGSAGLGVSLKGNKSRET--GTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGK 561
+G GLG+S+ G K G D GIFI + G A + G +R+ D+L+ VNG +L G
Sbjct: 735 TG--GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGA 791
Query: 562 SNHEAMETLR 571
+HEA+E LR
Sbjct: 792 EHHEAVEALR 801
Score = 48.1 bits (113), Expect = 4e-05
Identities = 25/57 (43%), Positives = 38/57 (66%), Gaps = 2/57 (3%)
Query: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVI 466
IF+ + P GAA +DGRL+ G R+LEVN + + G T E V +LRS G+T ++++
Sbjct: 1134 IFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSV--GDTLTVLV 1188
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 85.5 bits (210), Expect = 3e-16
Identities = 85/298 (28%), Positives = 128/298 (42%), Gaps = 50/298 (16%)
Query: 374 GSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGD 431
GS+ K +I L++G GLGF++ + H P IF+ I+P GAA DGRL D
Sbjct: 122 GSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVND 181
Query: 432 RILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLET 491
+L VN DV+ V L+ G LV+ R++
Sbjct: 182 CVLRVNEVDVSEVVHSRAVEALKEA--GPVVRLVVRRRQ--------------------P 219
Query: 492 SEQLTFEIPLNDSGSAGLGVSLKGN-KSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQL 550
+ E+ L G GLG S+ G ++ D I+I II GGAA KDGRL++ D+L
Sbjct: 220 PPETIMEVNLL-KGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRL 278
Query: 551 IAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKPCF 610
+AVN +L + EA+ +L+ N M+ L + + + D ++ P +
Sbjct: 279 LAVNNTNLQDVRHEEAVASLK-------NTSDMVYLKVAKPGSLHLND-----MYAPPDY 326
Query: 611 ENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPP---SPTPHSAL 665
+ A+ + + NS L LG + A +VPP SP P L
Sbjct: 327 ASTFTALADNHISHNSSLGYLGAVESKVSYP---------APPQVPPTRYSPIPRHML 375
Score = 82.4 bits (202), Expect = 2e-15
Identities = 67/239 (28%), Positives = 108/239 (45%), Gaps = 55/239 (23%)
Query: 382 IKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGDRILEVNGR 439
++++L KGP+GLGF++ + H PG I++ I+ GAA KDGRLQ GDR+L VN
Sbjct: 225 MEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNT 284
Query: 440 DVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCC-------------- 485
++ EE VA L++T + L +A+ G ++ PD
Sbjct: 285 NLQDVRHEEAVASLKNTS--DMVYLKVAKP-GSLHLNDMYAPPDYASTFTALADNHISHN 341
Query: 486 -------ALSLETSEQLTFEIP------------------------LNDSGSAGLGVSLK 514
A+ + S ++P + GS GLG ++
Sbjct: 342 SSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIV 401
Query: 515 GNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 573
G + E GIF+ I+ GG A G LR D++++VNG +L ++ +A L+R+
Sbjct: 402 GGEDGE-----GIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRA 455
Score = 52.0 bits (123), Expect = 3e-06
Identities = 35/79 (44%), Positives = 42/79 (53%), Gaps = 4/79 (5%)
Query: 383 KIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVT 442
KI L KG GLGF +V + G G IFV IL G A G L+ GDRIL VNG ++
Sbjct: 386 KIILHKGSTGLGFNIVGGED---GEG-IFVSFILAGGPADLSGELRRGDRILSVNGVNLR 441
Query: 443 GRTQEELVAMLRSTKQGET 461
T E+ A L+ Q T
Sbjct: 442 NATHEQAAAALKRAGQSVT 460
Score = 31.6 bits (70), Expect = 4.3
Identities = 21/84 (25%), Positives = 39/84 (46%), Gaps = 6/84 (7%)
Query: 230 GLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLP 289
G+FI I + +G N+C++++N VD+ + ++A + ++A P V L V
Sbjct: 159 GIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEA--GPVVRLVV-- 214
Query: 290 PQNREQYEKSVIGSLNIFGNNDGV 313
R Q I +N+ G+
Sbjct: 215 --RRRQPPPETIMEVNLLKGPKGL 236
>gi|24025688 ligand of numb-protein X 2 [Homo sapiens]
Length = 690
Score = 85.1 bits (209), Expect = 3e-16
Identities = 67/205 (32%), Positives = 97/205 (47%), Gaps = 18/205 (8%)
Query: 384 IDLKKGP-EGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVT 442
I +KK P E LG TV S G PIFV ++ P G +DGR++ GD +L +NG D+T
Sbjct: 469 ITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLT 528
Query: 443 GRTQEELVAMLRSTKQGETASLVI--------ARQEGHFLPREL-KGEPDCCA------- 486
+ E VAML+++ +L A Q P + E D
Sbjct: 529 NLSHSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMW 588
Query: 487 LSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRM 546
L L ++ +I L S G S+ G E T+ FIK+I+ G A+ DGRL+
Sbjct: 589 LGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYE-ENHTNQPFFIKTIVLGTPAYYDGRLKC 647
Query: 547 NDQLIAVNGESLLGKSNHEAMETLR 571
D ++AVNG S +G S+ + L+
Sbjct: 648 GDMIVAVNGLSTVGMSHSALVPMLK 672
Score = 70.9 bits (172), Expect = 6e-12
Identities = 58/211 (27%), Positives = 96/211 (45%), Gaps = 25/211 (11%)
Query: 381 KIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440
++ + + E LG +V R PG +F+ ++L G A +DGRL S DR+L +NG D
Sbjct: 339 QVALHKRDSGEQLGIKLVRRTDE---PG-VFILDLLEGGLAAQDGRLSSNDRVLAINGHD 394
Query: 441 VTGRTQEELVAMLRSTKQGETASLVIAR----QEG--------------HFLPRELKGEP 482
+ T E +++++ GE +L IAR Q G H P P
Sbjct: 395 LKYGTPELAAQIIQAS--GERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRP 452
Query: 483 DCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDG 542
+ I + LG+++ G + ++G +L IF+ S+ G +DG
Sbjct: 453 SSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSKSG-ELPIFVTSVPPHGCLARDG 511
Query: 543 RLRMNDQLIAVNGESLLGKSNHEAMETLRRS 573
R++ D L+ +NG L S+ EA+ L+ S
Sbjct: 512 RIKRGDVLLNINGIDLTNLSHSEAVAMLKAS 542
Score = 56.6 bits (135), Expect = 1e-07
Identities = 46/151 (30%), Positives = 78/151 (51%), Gaps = 17/151 (11%)
Query: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469
I ++ + G +DGRL +GD+IL+VN +++ + A+L ++ T L + R+
Sbjct: 260 IVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVL--SQPCNTLHLTVLRE 317
Query: 470 EGHFLPRELKGEPDCCALSLETSEQLTFEIPLN--DSGSAGLGVSLKGNKSRETGTDLGI 527
R + S E++ F++ L+ DSG LG+ L R T + G+
Sbjct: 318 ------RRFGNRAHNHSDSNSPREEI-FQVALHKRDSGEQ-LGIKLV----RRTD-EPGV 364
Query: 528 FIKSIIHGGAAFKDGRLRMNDQLIAVNGESL 558
FI ++ GG A +DGRL ND+++A+NG L
Sbjct: 365 FILDLLEGGLAAQDGRLSSNDRVLAINGHDL 395
Score = 55.5 bits (132), Expect = 3e-07
Identities = 58/253 (22%), Positives = 97/253 (38%), Gaps = 48/253 (18%)
Query: 213 LGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQD 272
LG+ V S SG L +F+ + + R+G + ++ IN +DL + + ++A
Sbjct: 479 LGMTVAGGRGSKSGE-LPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVA 537
Query: 273 VFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTAN 332
+ + + SP+V L L Q E+ ++ + F N
Sbjct: 538 MLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSEN---------------------- 575
Query: 333 LTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEG 392
E DAS S PS +G S ++ + +
Sbjct: 576 -------EYDASWS------------------PSWVMWLGLPSTLHSCHDIVLRRSYLGS 610
Query: 393 LGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAM 452
GF++V H P F+K I+ A DGRL+ GD I+ VNG G + LV M
Sbjct: 611 WGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPM 670
Query: 453 LRSTKQGETASLV 465
L+ + T +++
Sbjct: 671 LKEQRNKVTLTVI 683
Score = 33.9 bits (76), Expect = 0.87
Identities = 25/84 (29%), Positives = 39/84 (46%), Gaps = 4/84 (4%)
Query: 487 LSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRM 546
LSL E T EI ++ LG+S+ G + I I+ + G +DGRL
Sbjct: 224 LSLPEGEITTIEIHRSNP-YIQLGISIVGGNETPL---INIVIQEVYRDGVIARDGRLLA 279
Query: 547 NDQLIAVNGESLLGKSNHEAMETL 570
DQ++ VN ++ S++ A L
Sbjct: 280 GDQILQVNNYNISNVSHNYARAVL 303
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 83.2 bits (204), Expect = 1e-15
Identities = 102/404 (25%), Positives = 164/404 (40%), Gaps = 72/404 (17%)
Query: 380 KKIKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGDRILEVN 437
K ++I L KGP+GLGF++ + H PG I+V I+ GAA KDG+LQ GD++L VN
Sbjct: 316 KIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVN 375
Query: 438 GRDVTGRTQEELVAMLRSTKQGETASLVIARQ----------------------EGHFLP 475
+ T EE V L++T + L +A+ + H P
Sbjct: 376 NVCLEEVTHEEAVTALKNTS--DFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSP 433
Query: 476 RELKGEPDCC-------ALSLETSEQLTFE---IPLNDSGSAGLGVSLKGNKSRETGTDL 525
G+ + ++ +++T E + L+ GS GLG ++ G + E
Sbjct: 434 SSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLH-RGSTGLGFNIVGGEDGE----- 487
Query: 526 GIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQ 585
GIFI I+ GG A G LR D++I+VN L S+ +A L+ N +
Sbjct: 488 GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALK-------NAGQAVT 540
Query: 586 LVILRRPERPMEDPAECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLL 645
+V RPE A+ E N+ +S G+ S + QK L
Sbjct: 541 IVAQYRPEEYSRFEAKIHDLR----EQMMNSSISS-----------GSGSLRTSQKRSLY 585
Query: 646 PNDGWAESEVPPSPTPHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINL 705
+ + S P L D H D+ R VTP + + + +
Sbjct: 586 VRALFDYDKTKDSGLPSQGLNFKFGDILHVINASD-----DEWWQARQVTPDGESDEVGV 640
Query: 706 KASKSMDLVPDESKVHSLAGQKSESPSKDFGPTLGLKKSSSLES 749
SK + +++ ++ K S ++D G + K+ +L S
Sbjct: 641 IPSKRRVEKKERARLKTV---KFNSKTRDKGQSFNDKRKKNLFS 681
Score = 82.4 bits (202), Expect = 2e-15
Identities = 71/228 (31%), Positives = 111/228 (48%), Gaps = 30/228 (13%)
Query: 353 PRVPRLGGKP---SSPSL-SPLMGFGSNKNAKKIKIDLKKGPEGLGFTVV--TRDSSIHG 406
P +P+ P ++ SL +P G++ + + +I L++G GLGF++ T + I
Sbjct: 190 PTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGD 249
Query: 407 PGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVI 466
IF+ I+ GAA +DGRL+ D IL VN DV T + V L+ G L +
Sbjct: 250 DSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEA--GSIVRLYV 307
Query: 467 ARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRE-TGTDL 525
R++ SE++ EI L G GLG S+ G + D
Sbjct: 308 KRRK-------------------PVSEKI-MEIKLI-KGPKGLGFSIAGGVGNQHIPGDN 346
Query: 526 GIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 573
I++ II GGAA KDG+L++ D+L+AVN L ++ EA+ L+ +
Sbjct: 347 SIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNT 394
Score = 55.1 bits (131), Expect = 4e-07
Identities = 33/85 (38%), Positives = 50/85 (58%), Gaps = 6/85 (7%)
Query: 493 EQLTFEIPLNDSGSAGLGVSLKGNKSR-ETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLI 551
E++T E G++GLG S+ G G D IFI II GGAA +DGRLR+ND ++
Sbjct: 223 EEITLE-----RGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCIL 277
Query: 552 AVNGESLLGKSNHEAMETLRRSMSM 576
VN + ++ +A+E L+ + S+
Sbjct: 278 RVNEVDVRDVTHSKAVEALKEAGSI 302
Score = 52.4 bits (124), Expect = 2e-06
Identities = 46/152 (30%), Positives = 70/152 (46%), Gaps = 15/152 (9%)
Query: 314 LKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPS-LSPLMG 372
LK P ++ G ++T + S D S LG P+SP+ SP+
Sbjct: 400 LKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSF-------LGQTPASPARYSPVSK 452
Query: 373 --FGSNKNAKKI-KIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQS 429
G ++ ++ K+ L +G GLGF +V + G G IF+ IL G A G L+
Sbjct: 453 AVLGDDEITREPRKVVLHRGSTGLGFNIVGGED---GEG-IFISFILAGGPADLSGELRK 508
Query: 430 GDRILEVNGRDVTGRTQEELVAMLRSTKQGET 461
GDRI+ VN D+ + E+ A L++ Q T
Sbjct: 509 GDRIISVNSVDLRAASHEQAAAALKNAGQAVT 540
Score = 33.9 bits (76), Expect = 0.87
Identities = 14/47 (29%), Positives = 28/47 (59%)
Query: 231 LFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQA 277
+FI I + ++G N+CI+++N VD+ D T ++A + ++A
Sbjct: 253 IFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEA 299
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 83.2 bits (204), Expect = 1e-15
Identities = 72/280 (25%), Positives = 121/280 (43%), Gaps = 30/280 (10%)
Query: 315 KTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG 374
KTK P G S + + G + +S Q +++P+ +S ++ F
Sbjct: 1112 KTKKP----GISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMN-FKTFS 1166
Query: 375 SN--KNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDR 432
S+ K +++L K LG +V ++ G I+VK ++P+GAA DGR+ GDR
Sbjct: 1167 SSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDR 1226
Query: 433 ILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLE-- 490
+L VNG + G T ++ V LR+T G+ L++ + + + P C
Sbjct: 1227 VLAVNGVSLEGATHKQAVETLRNT--GQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQ 1284
Query: 491 ------------------TSEQLTFEIPL-NDSGSAGLGVSLKGNKSRETGTDLGIFIKS 531
+E+ TFE+ L +S G S + N E + +K
Sbjct: 1285 GQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKK 1344
Query: 532 IIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLR 571
+ G A + G++ + D ++ VNG SL G S E + LR
Sbjct: 1345 LFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALR 1384
Score = 57.8 bits (138), Expect = 6e-08
Identities = 95/437 (21%), Positives = 168/437 (38%), Gaps = 81/437 (18%)
Query: 163 LKLVVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFS 222
L++ S Q+ +D +VL+ + +++SP + TL ++ + + LG ++
Sbjct: 869 LQMRARQSNQDAQDIDVLHK-RWSIVSSPEREITLVNLKKDAKYG-----LGFQIIG--G 920
Query: 223 SLSGRI-LGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQA---- 277
GR+ LG+FI + + +G + ++ +N+V L + A ++ + A
Sbjct: 921 EKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDV 980
Query: 278 -----------MKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNND------GVLKTKVPP 320
K PS +H+ + S + I ++ G L+
Sbjct: 981 TLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISEN 1040
Query: 321 PVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSL--SPLMGFGSNKN 378
GL+ +L+ DS AS S Q LG + S SP S
Sbjct: 1041 SFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKAT 1100
Query: 379 AKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNG 438
K+ D + S PG V + +G + D S +
Sbjct: 1101 EKETFTD-------------SNQSKTKKPGISDVTDYSDRGDSDMDEATYSSSQD----- 1142
Query: 439 RDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFE 498
T + E++S V + +F + P + + E
Sbjct: 1143 ---------------HQTPKQESSSSVNTSNKMNF--KTFSSSPP------KPGDIFEVE 1179
Query: 499 IPLNDSGSAGLGVSLKG--NKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGE 556
+ ND+ LG+S+ G N S G GI++K++I GAA DGR+ D+++AVNG
Sbjct: 1180 LAKNDNS---LGISVTGGVNTSVRHG---GIYVKAVIPQGAAESDGRIHKGDRVLAVNGV 1233
Query: 557 SLLGKSNHEAMETLRRS 573
SL G ++ +A+ETLR +
Sbjct: 1234 SLEGATHKQAVETLRNT 1250
Score = 55.5 bits (132), Expect = 3e-07
Identities = 65/311 (20%), Positives = 118/311 (37%), Gaps = 68/311 (21%)
Query: 204 VEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLV 263
VE++ LGI V ++ S R G++++ + ++ +G H+ + ++ +N V L
Sbjct: 1178 VELAKNDNSLGISVTGGVNT-SVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLE 1236
Query: 264 DKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVH 323
T QA + R + ++H+L + + K + PV
Sbjct: 1237 GATHKQAVETLRNTGQ----VVHLLLEKGQSPTSKEHV-------------------PVT 1273
Query: 324 GKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIK 383
+ L N G + + ++ F + +N ++K
Sbjct: 1274 PQCTLSDQNAQGQGPEKVKKTTQVKD---------------------YSFVTEENTFEVK 1312
Query: 384 IDLKKGPEGLGFTVVTRDSSIH---GPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440
L K GLGF+ D+ I + VK + P A + G++ GD IL+VNG
Sbjct: 1313 --LFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1370
Query: 441 VTGRTQEELVAMLRST----------------KQGETASLVIARQEGHFLPRELK--GEP 482
+ G +Q+E+++ LR T + +TA L + LP K +P
Sbjct: 1371 LKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQP 1430
Query: 483 DCCALSLETSE 493
C S + E
Sbjct: 1431 SCVEQSTSSDE 1441
Score = 49.7 bits (117), Expect = 2e-05
Identities = 73/286 (25%), Positives = 113/286 (39%), Gaps = 37/286 (12%)
Query: 381 KIKIDLKKGPEG-LGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGR 439
++ I L K +G LGFTV + I +V +++ + A DGRL+ GDR+++VN
Sbjct: 1595 ELLITLIKSEKGSLGFTVTKGNQRIG----CYVHDVI-QDPAKSDGRLKPGDRLIKVNDT 1649
Query: 440 DVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEI 499
DVT T + V +LR+ +T LVI R LPR + L +I
Sbjct: 1650 DVTNMTHTDAVNLLRAA--SKTVRLVIGRVLE--LPR------------IPMLPHLLPDI 1693
Query: 500 PLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLL 559
L LG SL G ++I I A +G L++ D + VNG S
Sbjct: 1694 TLT-CNKEELGFSLCGGHDSLYQV---VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQ 1749
Query: 560 GKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAE---------CGAFSKPCF 610
G + E L S+ L ++ +R + G+ S+P
Sbjct: 1750 GMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPAL 1809
Query: 611 ENCQNAVTTSRRNDNSILHPLGTCSPQD--KQKGLLLPNDGWAESE 654
+ T + N I +P G CS L LP + + + +
Sbjct: 1810 TPNDSFSTVAGEEINEISYPKGKCSTYQIKGSPNLTLPKESYIQED 1855
Score = 34.7 bits (78), Expect = 0.51
Identities = 29/107 (27%), Positives = 49/107 (45%), Gaps = 12/107 (11%)
Query: 490 ETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQ 549
E +L + ++ GS G V+ KGN+ +G ++ +I A DGRL+ D+
Sbjct: 1591 ELEVELLITLIKSEKGSLGFTVT-KGNQR------IGCYVHDVIQDPAK-SDGRLKPGDR 1642
Query: 550 LIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPM 596
LI VN + ++ +A+ LR + + G +L P PM
Sbjct: 1643 LIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR----VLELPRIPM 1685
Score = 33.1 bits (74), Expect = 1.5
Identities = 35/122 (28%), Positives = 53/122 (43%), Gaps = 22/122 (18%)
Query: 332 NLTGTDSPETDASAS----LQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLK 387
N+T TD+ +AS L + +PR+ P P L P + NK
Sbjct: 1653 NMTHTDAVNLLRAASKTVRLVIGRVLELPRI---PMLPHLLPDITLTCNK---------- 1699
Query: 388 KGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQE 447
E LGF++ S++ +++ +I P+ A +G LQ D I VNG G T E
Sbjct: 1700 ---EELGFSLCGGHDSLYQV--VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLE 1754
Query: 448 EL 449
E+
Sbjct: 1755 EV 1756
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 83.2 bits (204), Expect = 1e-15
Identities = 72/280 (25%), Positives = 121/280 (43%), Gaps = 30/280 (10%)
Query: 315 KTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG 374
KTK P G S + + G + +S Q +++P+ +S ++ F
Sbjct: 1303 KTKKP----GISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMN-FKTFS 1357
Query: 375 SN--KNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDR 432
S+ K +++L K LG +V ++ G I+VK ++P+GAA DGR+ GDR
Sbjct: 1358 SSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDR 1417
Query: 433 ILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLE-- 490
+L VNG + G T ++ V LR+T G+ L++ + + + P C
Sbjct: 1418 VLAVNGVSLEGATHKQAVETLRNT--GQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQ 1475
Query: 491 ------------------TSEQLTFEIPL-NDSGSAGLGVSLKGNKSRETGTDLGIFIKS 531
+E+ TFE+ L +S G S + N E + +K
Sbjct: 1476 GQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKK 1535
Query: 532 IIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLR 571
+ G A + G++ + D ++ VNG SL G S E + LR
Sbjct: 1536 LFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALR 1575
Score = 55.5 bits (132), Expect = 3e-07
Identities = 65/311 (20%), Positives = 118/311 (37%), Gaps = 68/311 (21%)
Query: 204 VEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLV 263
VE++ LGI V ++ S R G++++ + ++ +G H+ + ++ +N V L
Sbjct: 1369 VELAKNDNSLGISVTGGVNT-SVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLE 1427
Query: 264 DKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVH 323
T QA + R + ++H+L + + K + PV
Sbjct: 1428 GATHKQAVETLRNTGQ----VVHLLLEKGQSPTSKEHV-------------------PVT 1464
Query: 324 GKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIK 383
+ L N G + + ++ F + +N ++K
Sbjct: 1465 PQCTLSDQNAQGQGPEKVKKTTQVKD---------------------YSFVTEENTFEVK 1503
Query: 384 IDLKKGPEGLGFTVVTRDSSIH---GPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440
L K GLGF+ D+ I + VK + P A + G++ GD IL+VNG
Sbjct: 1504 --LFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1561
Query: 441 VTGRTQEELVAMLRST----------------KQGETASLVIARQEGHFLPRELK--GEP 482
+ G +Q+E+++ LR T + +TA L + LP K +P
Sbjct: 1562 LKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQP 1621
Query: 483 DCCALSLETSE 493
C S + E
Sbjct: 1622 SCVEQSTSSDE 1632
Score = 54.7 bits (130), Expect = 5e-07
Identities = 33/79 (41%), Positives = 52/79 (65%), Gaps = 6/79 (7%)
Query: 497 FEIPLNDSGSAGLGVSLKG--NKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVN 554
FE+ L + ++ LG+S+ G N S G GI++K++I GAA DGR+ D+++AVN
Sbjct: 1367 FEVELAKNDNS-LGISVTGGVNTSVRHG---GIYVKAVIPQGAAESDGRIHKGDRVLAVN 1422
Query: 555 GESLLGKSNHEAMETLRRS 573
G SL G ++ +A+ETLR +
Sbjct: 1423 GVSLEGATHKQAVETLRNT 1441
Score = 52.0 bits (123), Expect = 3e-06
Identities = 31/75 (41%), Positives = 42/75 (56%), Gaps = 1/75 (1%)
Query: 499 IPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESL 558
+ L GLG + G + DLGIFI S+ GG A DG L+ D+LI+VN SL
Sbjct: 1094 VNLKKDAKYGLGFQIIGGEKMGR-LDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSL 1152
Query: 559 LGKSNHEAMETLRRS 573
G S+H A+E L+ +
Sbjct: 1153 EGVSHHAAIEILQNA 1167
Score = 49.7 bits (117), Expect = 2e-05
Identities = 73/286 (25%), Positives = 113/286 (39%), Gaps = 37/286 (12%)
Query: 381 KIKIDLKKGPEG-LGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGR 439
++ I L K +G LGFTV + I +V +++ + A DGRL+ GDR+++VN
Sbjct: 1786 ELLITLIKSEKGSLGFTVTKGNQRIG----CYVHDVI-QDPAKSDGRLKPGDRLIKVNDT 1840
Query: 440 DVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEI 499
DVT T + V +LR+ +T LVI R LPR + L +I
Sbjct: 1841 DVTNMTHTDAVNLLRAA--SKTVRLVIGRVLE--LPR------------IPMLPHLLPDI 1884
Query: 500 PLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLL 559
L LG SL G ++I I A +G L++ D + VNG S
Sbjct: 1885 TLT-CNKEELGFSLCGGHDSLYQV---VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQ 1940
Query: 560 GKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAE---------CGAFSKPCF 610
G + E L S+ L ++ +R + G+ S+P
Sbjct: 1941 GMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPAL 2000
Query: 611 ENCQNAVTTSRRNDNSILHPLGTCSPQD--KQKGLLLPNDGWAESE 654
+ T + N I +P G CS L LP + + + +
Sbjct: 2001 TPNDSFSTVAGEEINEISYPKGKCSTYQIKGSPNLTLPKESYIQED 2046
Score = 41.6 bits (96), Expect = 0.004
Identities = 26/86 (30%), Positives = 47/86 (54%), Gaps = 3/86 (3%)
Query: 384 IDLKKGPE-GLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVT 442
++LKK + GLGF ++ + IF+ ++ P G A DG L+ GDR++ VN +
Sbjct: 1094 VNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 1153
Query: 443 GRTQEELVAMLRSTKQGETASLVIAR 468
G + + +L++ E +LVI++
Sbjct: 1154 GVSHHAAIEILQNAP--EDVTLVISQ 1177
Score = 34.7 bits (78), Expect = 0.51
Identities = 29/107 (27%), Positives = 49/107 (45%), Gaps = 12/107 (11%)
Query: 490 ETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQ 549
E +L + ++ GS G V+ KGN+ +G ++ +I A DGRL+ D+
Sbjct: 1782 ELEVELLITLIKSEKGSLGFTVT-KGNQR------IGCYVHDVIQDPAK-SDGRLKPGDR 1833
Query: 550 LIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPM 596
LI VN + ++ +A+ LR + + G +L P PM
Sbjct: 1834 LIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR----VLELPRIPM 1876
Score = 33.1 bits (74), Expect = 1.5
Identities = 35/122 (28%), Positives = 53/122 (43%), Gaps = 22/122 (18%)
Query: 332 NLTGTDSPETDASAS----LQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLK 387
N+T TD+ +AS L + +PR+ P P L P + NK
Sbjct: 1844 NMTHTDAVNLLRAASKTVRLVIGRVLELPRI---PMLPHLLPDITLTCNK---------- 1890
Query: 388 KGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQE 447
E LGF++ S++ +++ +I P+ A +G LQ D I VNG G T E
Sbjct: 1891 ---EELGFSLCGGHDSLYQV--VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLE 1945
Query: 448 EL 449
E+
Sbjct: 1946 EV 1947
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
2 [Homo sapiens]
Length = 2466
Score = 83.2 bits (204), Expect = 1e-15
Identities = 72/280 (25%), Positives = 121/280 (43%), Gaps = 30/280 (10%)
Query: 315 KTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG 374
KTK P G S + + G + +S Q +++P+ +S ++ F
Sbjct: 1284 KTKKP----GISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMN-FKTFS 1338
Query: 375 SN--KNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDR 432
S+ K +++L K LG +V ++ G I+VK ++P+GAA DGR+ GDR
Sbjct: 1339 SSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDR 1398
Query: 433 ILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLE-- 490
+L VNG + G T ++ V LR+T G+ L++ + + + P C
Sbjct: 1399 VLAVNGVSLEGATHKQAVETLRNT--GQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQ 1456
Query: 491 ------------------TSEQLTFEIPL-NDSGSAGLGVSLKGNKSRETGTDLGIFIKS 531
+E+ TFE+ L +S G S + N E + +K
Sbjct: 1457 GQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKK 1516
Query: 532 IIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLR 571
+ G A + G++ + D ++ VNG SL G S E + LR
Sbjct: 1517 LFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALR 1556
Score = 55.5 bits (132), Expect = 3e-07
Identities = 65/311 (20%), Positives = 118/311 (37%), Gaps = 68/311 (21%)
Query: 204 VEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLV 263
VE++ LGI V ++ S R G++++ + ++ +G H+ + ++ +N V L
Sbjct: 1350 VELAKNDNSLGISVTGGVNT-SVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLE 1408
Query: 264 DKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVH 323
T QA + R + ++H+L + + K + PV
Sbjct: 1409 GATHKQAVETLRNTGQ----VVHLLLEKGQSPTSKEHV-------------------PVT 1445
Query: 324 GKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIK 383
+ L N G + + ++ F + +N ++K
Sbjct: 1446 PQCTLSDQNAQGQGPEKVKKTTQVKD---------------------YSFVTEENTFEVK 1484
Query: 384 IDLKKGPEGLGFTVVTRDSSIH---GPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440
L K GLGF+ D+ I + VK + P A + G++ GD IL+VNG
Sbjct: 1485 --LFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1542
Query: 441 VTGRTQEELVAMLRST----------------KQGETASLVIARQEGHFLPRELK--GEP 482
+ G +Q+E+++ LR T + +TA L + LP K +P
Sbjct: 1543 LKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQP 1602
Query: 483 DCCALSLETSE 493
C S + E
Sbjct: 1603 SCVEQSTSSDE 1613
Score = 54.7 bits (130), Expect = 5e-07
Identities = 33/79 (41%), Positives = 52/79 (65%), Gaps = 6/79 (7%)
Query: 497 FEIPLNDSGSAGLGVSLKG--NKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVN 554
FE+ L + ++ LG+S+ G N S G GI++K++I GAA DGR+ D+++AVN
Sbjct: 1348 FEVELAKNDNS-LGISVTGGVNTSVRHG---GIYVKAVIPQGAAESDGRIHKGDRVLAVN 1403
Query: 555 GESLLGKSNHEAMETLRRS 573
G SL G ++ +A+ETLR +
Sbjct: 1404 GVSLEGATHKQAVETLRNT 1422
Score = 52.0 bits (123), Expect = 3e-06
Identities = 31/75 (41%), Positives = 42/75 (56%), Gaps = 1/75 (1%)
Query: 499 IPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESL 558
+ L GLG + G + DLGIFI S+ GG A DG L+ D+LI+VN SL
Sbjct: 1075 VNLKKDAKYGLGFQIIGGEKMGR-LDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSL 1133
Query: 559 LGKSNHEAMETLRRS 573
G S+H A+E L+ +
Sbjct: 1134 EGVSHHAAIEILQNA 1148
Score = 49.7 bits (117), Expect = 2e-05
Identities = 73/286 (25%), Positives = 113/286 (39%), Gaps = 37/286 (12%)
Query: 381 KIKIDLKKGPEG-LGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGR 439
++ I L K +G LGFTV + I +V +++ + A DGRL+ GDR+++VN
Sbjct: 1767 ELLITLIKSEKGSLGFTVTKGNQRIG----CYVHDVI-QDPAKSDGRLKPGDRLIKVNDT 1821
Query: 440 DVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEI 499
DVT T + V +LR+ +T LVI R LPR + L +I
Sbjct: 1822 DVTNMTHTDAVNLLRAA--SKTVRLVIGRVLE--LPR------------IPMLPHLLPDI 1865
Query: 500 PLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLL 559
L LG SL G ++I I A +G L++ D + VNG S
Sbjct: 1866 TLT-CNKEELGFSLCGGHDSLYQV---VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQ 1921
Query: 560 GKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAE---------CGAFSKPCF 610
G + E L S+ L ++ +R + G+ S+P
Sbjct: 1922 GMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPAL 1981
Query: 611 ENCQNAVTTSRRNDNSILHPLGTCSPQD--KQKGLLLPNDGWAESE 654
+ T + N I +P G CS L LP + + + +
Sbjct: 1982 TPNDSFSTVAGEEINEISYPKGKCSTYQIKGSPNLTLPKESYIQED 2027
Score = 41.6 bits (96), Expect = 0.004
Identities = 26/86 (30%), Positives = 47/86 (54%), Gaps = 3/86 (3%)
Query: 384 IDLKKGPE-GLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVT 442
++LKK + GLGF ++ + IF+ ++ P G A DG L+ GDR++ VN +
Sbjct: 1075 VNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 1134
Query: 443 GRTQEELVAMLRSTKQGETASLVIAR 468
G + + +L++ E +LVI++
Sbjct: 1135 GVSHHAAIEILQNAP--EDVTLVISQ 1158
Score = 34.7 bits (78), Expect = 0.51
Identities = 29/107 (27%), Positives = 49/107 (45%), Gaps = 12/107 (11%)
Query: 490 ETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQ 549
E +L + ++ GS G V+ KGN+ +G ++ +I A DGRL+ D+
Sbjct: 1763 ELEVELLITLIKSEKGSLGFTVT-KGNQR------IGCYVHDVIQDPAK-SDGRLKPGDR 1814
Query: 550 LIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPM 596
LI VN + ++ +A+ LR + + G +L P PM
Sbjct: 1815 LIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR----VLELPRIPM 1857
Score = 33.1 bits (74), Expect = 1.5
Identities = 35/122 (28%), Positives = 53/122 (43%), Gaps = 22/122 (18%)
Query: 332 NLTGTDSPETDASAS----LQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLK 387
N+T TD+ +AS L + +PR+ P P L P + NK
Sbjct: 1825 NMTHTDAVNLLRAASKTVRLVIGRVLELPRI---PMLPHLLPDITLTCNK---------- 1871
Query: 388 KGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQE 447
E LGF++ S++ +++ +I P+ A +G LQ D I VNG G T E
Sbjct: 1872 ---EELGFSLCGGHDSLYQV--VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLE 1926
Query: 448 EL 449
E+
Sbjct: 1927 EV 1928
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 82.4 bits (202), Expect = 2e-15
Identities = 71/228 (31%), Positives = 111/228 (48%), Gaps = 30/228 (13%)
Query: 353 PRVPRLGGKP---SSPSL-SPLMGFGSNKNAKKIKIDLKKGPEGLGFTVV--TRDSSIHG 406
P +P+ P ++ SL +P G++ + + +I L++G GLGF++ T + I
Sbjct: 190 PTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGD 249
Query: 407 PGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVI 466
IF+ I+ GAA +DGRL+ D IL VN DV T + V L+ G L +
Sbjct: 250 DSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEA--GSIVRLYV 307
Query: 467 ARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRE-TGTDL 525
R++ SE++ EI L G GLG S+ G + D
Sbjct: 308 KRRK-------------------PVSEKI-MEIKLI-KGPKGLGFSIAGGVGNQHIPGDN 346
Query: 526 GIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 573
I++ II GGAA KDG+L++ D+L+AVN L ++ EA+ L+ +
Sbjct: 347 SIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNT 394
Score = 81.3 bits (199), Expect = 5e-15
Identities = 83/304 (27%), Positives = 130/304 (42%), Gaps = 49/304 (16%)
Query: 380 KKIKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGDRILEVN 437
K ++I L KGP+GLGF++ + H PG I+V I+ GAA KDG+LQ GD++L VN
Sbjct: 316 KIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVN 375
Query: 438 GRDVTGRTQEELVAMLRSTKQGETASLVIARQ----------------------EGHFLP 475
+ T EE V L++T + L +A+ + H P
Sbjct: 376 NVCLEEVTHEEAVTALKNTS--DFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSP 433
Query: 476 RELKGEPDCC-------ALSLETSEQLTFE---IPLNDSGSAGLGVSLKGNKSRETGTDL 525
G+ + ++ +++T E + L+ GS GLG ++ G + E
Sbjct: 434 SSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLH-RGSTGLGFNIVGGEDGE----- 487
Query: 526 GIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQ 585
GIFI I+ GG A G LR D++I+VN L S+ +A L+ N +
Sbjct: 488 GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALK-------NAGQAVT 540
Query: 586 LVILRRPERPMEDPAECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLL 645
+V RPE A+ + + ++ + S R + DK K L
Sbjct: 541 IVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGL 600
Query: 646 PNDG 649
P+ G
Sbjct: 601 PSQG 604
Score = 55.1 bits (131), Expect = 4e-07
Identities = 33/85 (38%), Positives = 50/85 (58%), Gaps = 6/85 (7%)
Query: 493 EQLTFEIPLNDSGSAGLGVSLKGNKSR-ETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLI 551
E++T E G++GLG S+ G G D IFI II GGAA +DGRLR+ND ++
Sbjct: 223 EEITLE-----RGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCIL 277
Query: 552 AVNGESLLGKSNHEAMETLRRSMSM 576
VN + ++ +A+E L+ + S+
Sbjct: 278 RVNEVDVRDVTHSKAVEALKEAGSI 302
Score = 52.4 bits (124), Expect = 2e-06
Identities = 46/152 (30%), Positives = 70/152 (46%), Gaps = 15/152 (9%)
Query: 314 LKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPS-LSPLMG 372
LK P ++ G ++T + S D S LG P+SP+ SP+
Sbjct: 400 LKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSF-------LGQTPASPARYSPVSK 452
Query: 373 --FGSNKNAKKI-KIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQS 429
G ++ ++ K+ L +G GLGF +V + G G IF+ IL G A G L+
Sbjct: 453 AVLGDDEITREPRKVVLHRGSTGLGFNIVGGED---GEG-IFISFILAGGPADLSGELRK 508
Query: 430 GDRILEVNGRDVTGRTQEELVAMLRSTKQGET 461
GDRI+ VN D+ + E+ A L++ Q T
Sbjct: 509 GDRIISVNSVDLRAASHEQAAAALKNAGQAVT 540
Score = 33.9 bits (76), Expect = 0.87
Identities = 14/47 (29%), Positives = 28/47 (59%)
Query: 231 LFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQA 277
+FI I + ++G N+CI+++N VD+ D T ++A + ++A
Sbjct: 253 IFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEA 299
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 82.0 bits (201), Expect = 3e-15
Identities = 72/237 (30%), Positives = 105/237 (44%), Gaps = 54/237 (22%)
Query: 380 KKIKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGDRILEVN 437
K ++I L KGP+GLGF++ + H PG I+V I+ GAA KDGRLQ GD+IL VN
Sbjct: 200 KVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVN 259
Query: 438 GRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTF 497
+ E+ VA L++T + L +A+ +L + PD ++ S+ L
Sbjct: 260 SVGLEDVMHEDAVAALKNTY--DVVYLKVAKPSNAYL-SDSYAPPD---ITTSYSQHLDN 313
Query: 498 EIPLND-----------------------------------------SGSAGLGVSLKGN 516
EI + GS GLG ++ G
Sbjct: 314 EISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGG 373
Query: 517 KSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 573
+ E GIFI I+ GG A G LR DQ+++VNG L S+ +A L+ +
Sbjct: 374 EDGE-----GIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNA 425
Score = 80.1 bits (196), Expect = 1e-14
Identities = 63/194 (32%), Positives = 92/194 (47%), Gaps = 26/194 (13%)
Query: 383 KIDLKKGPEGLGFTVVTRDSSIH-GPGP-IFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440
+I L++G GLGF++ + H G P IF+ I+P GAA +DGRL+ D IL VN D
Sbjct: 108 EITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVD 167
Query: 441 VTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIP 500
V T V L+ G L + R++ + EI
Sbjct: 168 VREVTHSAAVEALKEA--GSIVRLYVMRRK--------------------PPAEKVMEIK 205
Query: 501 LNDSGSAGLGVSLKGNKSRE-TGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLL 559
L G GLG S+ G + D I++ II GGAA KDGRL++ D+++AVN L
Sbjct: 206 LI-KGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLE 264
Query: 560 GKSNHEAMETLRRS 573
+ +A+ L+ +
Sbjct: 265 DVMHEDAVAALKNT 278
Score = 57.0 bits (136), Expect = 1e-07
Identities = 35/102 (34%), Positives = 57/102 (55%), Gaps = 8/102 (7%)
Query: 491 TSEQLTFEIPLNDSGSAGLGVSLKGNKSR-ETGTDLGIFIKSIIHGGAAFKDGRLRMNDQ 549
T ++ +E + G++GLG S+ G G D IFI II GGAA +DGRLR+ND
Sbjct: 100 TEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDS 159
Query: 550 LIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRR 591
++ VN + ++ A+E L+ + S +++L ++RR
Sbjct: 160 ILFVNEVDVREVTHSAAVEALKEAGS-------IVRLYVMRR 194
Score = 48.5 bits (114), Expect = 3e-05
Identities = 102/441 (23%), Positives = 161/441 (36%), Gaps = 79/441 (17%)
Query: 58 ILDPDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFK- 116
+LD D + + K E+ PL SP+ P SP + ++
Sbjct: 38 LLDILDYYEASLSESQKYRYQDEDTPPLE--HSPAHLPNQANSPPVIVNTDTLEAPGYEL 95
Query: 117 ---PIGGEIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASH----PGG---QSLKLV 166
GE+E L+ G L + P PS PGG Q +L
Sbjct: 96 QVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLR 155
Query: 167 VPDS---TQNLEDREVLNGVQTELLTSPRTKDTLSDMTR------TVEISGEGGPLGIHV 217
V DS ++ REV + E L + L M R +EI GP G+
Sbjct: 156 VNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLG- 214
Query: 218 VPFFSSLSG----RILG---LFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQA 270
FS G I G +++ I + + ++G + I+ +N+V L D A
Sbjct: 215 ---FSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDA 271
Query: 271 QDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPV------HG 324
+ V L V P N + + PP + H
Sbjct: 272 VAALKNTYDV--VYLKVAKPSNAYLSD------------------SYAPPDITTSYSQHL 311
Query: 325 KSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKI 384
+ + ++ GTD P T + + + SP L G+ P + +I
Sbjct: 312 DNEISHSSYLGTDYP-TAMTPTSPRRYSPVAKDLLGEEDIPR-------------EPRRI 357
Query: 385 DLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGR 444
+ +G GLGF +V + G G IF+ IL G A G L+ GD+IL VNG D+
Sbjct: 358 VIHRGSTGLGFNIVGGED---GEG-IFISFILAGGPADLSGELRKGDQILSVNGVDLRNA 413
Query: 445 TQEELVAMLRSTKQGETASLV 465
+ E+ L++ G+T +++
Sbjct: 414 SHEQAAIALKNA--GQTVTII 432
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 82.0 bits (201), Expect = 3e-15
Identities = 72/237 (30%), Positives = 105/237 (44%), Gaps = 54/237 (22%)
Query: 380 KKIKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGDRILEVN 437
K ++I L KGP+GLGF++ + H PG I+V I+ GAA KDGRLQ GD+IL VN
Sbjct: 154 KVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVN 213
Query: 438 GRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTF 497
+ E+ VA L++T + L +A+ +L + PD ++ S+ L
Sbjct: 214 SVGLEDVMHEDAVAALKNTY--DVVYLKVAKPSNAYL-SDSYAPPD---ITTSYSQHLDN 267
Query: 498 EIPLND-----------------------------------------SGSAGLGVSLKGN 516
EI + GS GLG ++ G
Sbjct: 268 EISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGG 327
Query: 517 KSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 573
+ E GIFI I+ GG A G LR DQ+++VNG L S+ +A L+ +
Sbjct: 328 EDGE-----GIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNA 379
Score = 80.1 bits (196), Expect = 1e-14
Identities = 63/194 (32%), Positives = 92/194 (47%), Gaps = 26/194 (13%)
Query: 383 KIDLKKGPEGLGFTVVTRDSSIH-GPGP-IFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440
+I L++G GLGF++ + H G P IF+ I+P GAA +DGRL+ D IL VN D
Sbjct: 62 EITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVD 121
Query: 441 VTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIP 500
V T V L+ G L + R++ + EI
Sbjct: 122 VREVTHSAAVEALKEA--GSIVRLYVMRRK--------------------PPAEKVMEIK 159
Query: 501 LNDSGSAGLGVSLKGNKSRE-TGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLL 559
L G GLG S+ G + D I++ II GGAA KDGRL++ D+++AVN L
Sbjct: 160 LI-KGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLE 218
Query: 560 GKSNHEAMETLRRS 573
+ +A+ L+ +
Sbjct: 219 DVMHEDAVAALKNT 232
Score = 57.0 bits (136), Expect = 1e-07
Identities = 35/102 (34%), Positives = 57/102 (55%), Gaps = 8/102 (7%)
Query: 491 TSEQLTFEIPLNDSGSAGLGVSLKGNKSR-ETGTDLGIFIKSIIHGGAAFKDGRLRMNDQ 549
T ++ +E + G++GLG S+ G G D IFI II GGAA +DGRLR+ND
Sbjct: 54 TEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDS 113
Query: 550 LIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRR 591
++ VN + ++ A+E L+ + S +++L ++RR
Sbjct: 114 ILFVNEVDVREVTHSAAVEALKEAGS-------IVRLYVMRR 148
Score = 49.7 bits (117), Expect = 2e-05
Identities = 99/416 (23%), Positives = 153/416 (36%), Gaps = 76/416 (18%)
Query: 80 EEQEPLHKIESPSGNPADRQSPDAF-ETEVAAQLAAFKPIGGEIEVTPSALKLGTPLLVR 138
E+ PL SP+ P SP T+ GE+E L+ G L
Sbjct: 17 EDTPPLE--HSPAHLPNQANSPPVIVNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGF 74
Query: 139 RSSDPVPGPPADTQPSASH----PGG---QSLKLVVPDS---TQNLEDREVLNGVQTELL 188
+ P PS PGG Q +L V DS ++ REV + E L
Sbjct: 75 SIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEAL 134
Query: 189 TSPRTKDTLSDMTR------TVEISGEGGPLGIHVVPFFSSLSG----RILG---LFIRG 235
+ L M R +EI GP G+ FS G I G +++
Sbjct: 135 KEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLG----FSIAGGVGNQHIPGDNSIYVTK 190
Query: 236 IEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQ 295
I + + ++G + I+ +N+V L D A + V L V P N
Sbjct: 191 IIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDV--VYLKVAKPSNAYL 248
Query: 296 YEKSVIGSLNIFGNNDGVLKTKVPPPV------HGKSGLKTANLTGTDSPETDASASLQQ 349
+ + PP + H + + ++ GTD P T + + +
Sbjct: 249 SD------------------SYAPPDITTSYSQHLDNEISHSSYLGTDYP-TAMTPTSPR 289
Query: 350 NKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGP 409
SP L G+ P + +I + +G GLGF +V + G G
Sbjct: 290 RYSPVAKDLLGEEDIPR-------------EPRRIVIHRGSTGLGFNIVGGED---GEG- 332
Query: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLV 465
IF+ IL G A G L+ GD+IL VNG D+ + E+ L++ G+T +++
Sbjct: 333 IFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNA--GQTVTII 386
>gi|148833504 interleukin 16 isoform 2 [Homo sapiens]
Length = 1332
Score = 82.0 bits (201), Expect = 3e-15
Identities = 59/192 (30%), Positives = 90/192 (46%), Gaps = 25/192 (13%)
Query: 386 LKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRT 445
+K +GLGF++V SI+GP I+VK I GAA DGRLQ GD ILE+NG + G T
Sbjct: 220 MKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLT 279
Query: 446 QEELVAMLRSTKQGETASLVIARQE------GHFLP---RELKGE----PDCCALSLET- 491
++ + + K+G V R H P R L D + +LE+
Sbjct: 280 HQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESP 339
Query: 492 ---------SEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDG 542
+ ++ E+ L GLG+ L + + GIF+ ++ G A DG
Sbjct: 340 SAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCIS--GIFVHTLSPGSVAHLDG 397
Query: 543 RLRMNDQLIAVN 554
RLR D+++ ++
Sbjct: 398 RLRCGDEIVEIS 409
Score = 71.2 bits (173), Expect = 5e-12
Identities = 51/198 (25%), Positives = 94/198 (47%), Gaps = 15/198 (7%)
Query: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469
I V + P G A ++G +Q G+ +L +NG+ + G T + +A+LR ++ A +V +
Sbjct: 1139 ITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKL 1198
Query: 470 EGHFLPRELKGEPDCCA-------LSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETG 522
+P +L D A +S+E++ + T + SAGLG SL+G K G
Sbjct: 1199 TPEAMP-DLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHG 1257
Query: 523 TDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRG 582
D + I I G A+ + ++ D+++ + G ++ G + EA ++ G
Sbjct: 1258 -DKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPD------G 1310
Query: 583 MIQLVILRRPERPMEDPA 600
+ +VI R+ + E A
Sbjct: 1311 PVTIVIRRKSLQSKETTA 1328
Score = 63.5 bits (153), Expect = 1e-09
Identities = 40/142 (28%), Positives = 73/142 (51%), Gaps = 14/142 (9%)
Query: 499 IPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESL 558
I L + GLG S+ G K G +GI++K+I GGAA DGRL+ D+++ +NGES+
Sbjct: 217 IVLMKGQAKGLGFSIVGGKDSIYGP-IGIYVKTIFAGGAAAADGRLQEGDEILELNGESM 275
Query: 559 LGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKPCFENCQNAVT 618
G ++ +A++ +++ +G++ L + R P P+ C S P + ++
Sbjct: 276 AGLTHQDALQKFKQAK------KGLLTLTVRTRLTAP---PSLCSHLSPPLCRSLSSSTC 326
Query: 619 TSRRNDNSILH----PLGTCSP 636
++ + + L P+ T P
Sbjct: 327 ITKDSSSFALESPSAPISTAKP 348
Score = 46.2 bits (108), Expect = 2e-04
Identities = 36/144 (25%), Positives = 63/144 (43%), Gaps = 17/144 (11%)
Query: 342 DASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG----------------SNKNAKKIKID 385
DA A L+Q + PR + + +P P + S A +
Sbjct: 1177 DALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVT 1236
Query: 386 LKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRT 445
L+K GLGF++ S+HG P+ + I A+ + +Q GD IL++ G + G T
Sbjct: 1237 LEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLT 1296
Query: 446 QEELVAMLRSTKQGETASLVIARQ 469
+ E ++++ G ++VI R+
Sbjct: 1297 RFEAWNIIKALPDG-PVTIVIRRK 1319
Score = 45.4 bits (106), Expect = 3e-04
Identities = 67/300 (22%), Positives = 114/300 (38%), Gaps = 48/300 (16%)
Query: 183 VQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRS 242
+ T L P S ++ V + G+ LG +V S+ G I G++++ I +
Sbjct: 197 LSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPI-GIYVKTIFAGGAA 255
Query: 243 KREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIG 302
+G E + I+++N + T A F+QA K L L + R S+
Sbjct: 256 AADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKG----LLTLTVRTRLTAPPSLCS 311
Query: 303 SLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKP 362
L+ PP+ +L+ + D+S+ + SP P KP
Sbjct: 312 HLS--------------PPL-------CRSLSSSTCITKDSSSFALE--SPSAPISTAKP 348
Query: 363 SSPSLSPLMGFGSNKNAKKIKIDLKKGPE---GLGFTVVTRDSSIHGPGPIFVKNILPKG 419
+ + +++ L+K G+G V I G IFV + P
Sbjct: 349 NYRIM--------------VEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGS 391
Query: 420 AAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELK 479
A DGRL+ GD I+E++ V T E+ +L G +V + ++LK
Sbjct: 392 VAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLK 451
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 80.9 bits (198), Expect = 6e-15
Identities = 67/194 (34%), Positives = 96/194 (49%), Gaps = 26/194 (13%)
Query: 383 KIDLKKGPEGLGFTVVTRDSSIH-GPGP-IFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440
+I L++G GLGF++ + H G P IF+ I+P GAA +DGRL+ D IL VN D
Sbjct: 47 EITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVD 106
Query: 441 VTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIP 500
V+ + + V L+ G L + R+ LET EI
Sbjct: 107 VSEVSHSKAVEALKEA--GSIVRLYVRRRRP----------------ILET----VVEIK 144
Query: 501 LNDSGSAGLGVSLKGNKSRE-TGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLL 559
L G GLG S+ G + D I++ II GGAA KDGRL++ D+L+ VN SL
Sbjct: 145 LF-KGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLE 203
Query: 560 GKSNHEAMETLRRS 573
++ EA+ L+ +
Sbjct: 204 EVTHEEAVAILKNT 217
Score = 66.6 bits (161), Expect = 1e-10
Identities = 37/79 (46%), Positives = 51/79 (64%), Gaps = 2/79 (2%)
Query: 382 IKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGDRILEVNGR 439
++I L KGP+GLGF++ + H PG I+V I+ GAA KDGRLQ GDR+L VN
Sbjct: 141 VEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNY 200
Query: 440 DVTGRTQEELVAMLRSTKQ 458
+ T EE VA+L++T +
Sbjct: 201 SLEEVTHEEAVAILKNTSE 219
Score = 63.9 bits (154), Expect = 8e-10
Identities = 76/301 (25%), Positives = 126/301 (41%), Gaps = 49/301 (16%)
Query: 231 LFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMK-------SPSV 283
+++ I D ++++G + ++ +NN L + T +A + + + P+
Sbjct: 171 IYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTT 230
Query: 284 LLHVLP---PQNREQYEKSVIGSLNIFGNNDGVL--KTKVPPPVHGKSGLKTANLTGTDS 338
+ P P Y + L N+G L KT +PP G+ ++ D
Sbjct: 231 IYMTDPYGPPDITHSYSPPMENHL--LSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDD- 287
Query: 339 PETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVV 398
D ++ Q + + R P S + + + K+ L KG GLGF +V
Sbjct: 288 ---DYTSHSQHSTATRQP-----------SMTLQRAVSLEGEPRKVVLHKGSTGLGFNIV 333
Query: 399 TRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQ 458
+ G G IFV IL G A G LQ GD+IL VNG D+ G + E+ A L+
Sbjct: 334 GGED---GEG-IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA-- 387
Query: 459 GETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKS 518
G+T +++ Q + E K + EQ+ +N S S+G G SL+ N+
Sbjct: 388 GQTVTIIAQYQPEDYARFEAKIH--------DLREQM-----MNHSMSSGSG-SLRTNQK 433
Query: 519 R 519
R
Sbjct: 434 R 434
Score = 60.1 bits (144), Expect = 1e-08
Identities = 42/119 (35%), Positives = 60/119 (50%), Gaps = 9/119 (7%)
Query: 491 TSEQLTFEIPLNDSGSAGLGVSLKGNKSR-ETGTDLGIFIKSIIHGGAAFKDGRLRMNDQ 549
T + FE + G++GLG S+ G G D GIFI II GGAA +DGRLR+ND
Sbjct: 39 TEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDC 98
Query: 550 LIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKP 608
++ VN + S+ +A+E L+ + G I + +RR +E E F P
Sbjct: 99 ILRVNEVDVSEVSHSKAVEALKEA--------GSIVRLYVRRRRPILETVVEIKLFKGP 149
Score = 47.8 bits (112), Expect = 6e-05
Identities = 26/67 (38%), Positives = 38/67 (56%), Gaps = 5/67 (7%)
Query: 505 GSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNH 564
GS GLG ++ G + E GIF+ I+ GG A G L+ DQ+++VNG L G S+
Sbjct: 324 GSTGLGFNIVGGEDGE-----GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHE 378
Query: 565 EAMETLR 571
+A L+
Sbjct: 379 QAAAALK 385
Score = 33.1 bits (74), Expect = 1.5
Identities = 13/48 (27%), Positives = 28/48 (58%)
Query: 230 GLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQA 277
G+FI I + +G N+CI+++N VD+ + + ++A + ++A
Sbjct: 75 GIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEA 122
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 80.9 bits (198), Expect = 6e-15
Identities = 67/194 (34%), Positives = 96/194 (49%), Gaps = 26/194 (13%)
Query: 383 KIDLKKGPEGLGFTVVTRDSSIH-GPGP-IFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440
+I L++G GLGF++ + H G P IF+ I+P GAA +DGRL+ D IL VN D
Sbjct: 203 EITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVD 262
Query: 441 VTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIP 500
V+ + + V L+ G L + R+ LET EI
Sbjct: 263 VSEVSHSKAVEALKEA--GSIVRLYVRRRRP----------------ILET----VVEIK 300
Query: 501 LNDSGSAGLGVSLKGNKSRE-TGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLL 559
L G GLG S+ G + D I++ II GGAA KDGRL++ D+L+ VN SL
Sbjct: 301 LF-KGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLE 359
Query: 560 GKSNHEAMETLRRS 573
++ EA+ L+ +
Sbjct: 360 EVTHEEAVAILKNT 373
Score = 66.6 bits (161), Expect = 1e-10
Identities = 37/79 (46%), Positives = 51/79 (64%), Gaps = 2/79 (2%)
Query: 382 IKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGDRILEVNGR 439
++I L KGP+GLGF++ + H PG I+V I+ GAA KDGRLQ GDR+L VN
Sbjct: 297 VEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNY 356
Query: 440 DVTGRTQEELVAMLRSTKQ 458
+ T EE VA+L++T +
Sbjct: 357 SLEEVTHEEAVAILKNTSE 375
Score = 60.1 bits (144), Expect = 1e-08
Identities = 42/119 (35%), Positives = 60/119 (50%), Gaps = 9/119 (7%)
Query: 491 TSEQLTFEIPLNDSGSAGLGVSLKGNKSR-ETGTDLGIFIKSIIHGGAAFKDGRLRMNDQ 549
T + FE + G++GLG S+ G G D GIFI II GGAA +DGRLR+ND
Sbjct: 195 TEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDC 254
Query: 550 LIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKP 608
++ VN + S+ +A+E L+ + G I + +RR +E E F P
Sbjct: 255 ILRVNEVDVSEVSHSKAVEALKEA--------GSIVRLYVRRRRPILETVVEIKLFKGP 305
Score = 57.4 bits (137), Expect = 7e-08
Identities = 49/137 (35%), Positives = 68/137 (49%), Gaps = 20/137 (14%)
Query: 383 KIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVT 442
K+ L KG GLGF +V + G G IFV IL G A G LQ GD+IL VNG D+
Sbjct: 526 KVVLHKGSTGLGFNIVGGED---GEG-IFVSFILAGGPADLSGELQRGDQILSVNGIDLR 581
Query: 443 GRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLN 502
G + E+ A L+ G+T +++ Q + E K + EQ+ +N
Sbjct: 582 GASHEQAAAALKGA--GQTVTIIAQYQPEDYARFEAKIH--------DLREQM-----MN 626
Query: 503 DSGSAGLGVSLKGNKSR 519
S S+G G SL+ N+ R
Sbjct: 627 HSMSSGSG-SLRTNQKR 642
Score = 47.8 bits (112), Expect = 6e-05
Identities = 26/67 (38%), Positives = 38/67 (56%), Gaps = 5/67 (7%)
Query: 505 GSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNH 564
GS GLG ++ G + E GIF+ I+ GG A G L+ DQ+++VNG L G S+
Sbjct: 532 GSTGLGFNIVGGEDGE-----GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHE 586
Query: 565 EAMETLR 571
+A L+
Sbjct: 587 QAAAALK 593
Score = 33.1 bits (74), Expect = 1.5
Identities = 13/48 (27%), Positives = 28/48 (58%)
Query: 230 GLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQA 277
G+FI I + +G N+CI+++N VD+ + + ++A + ++A
Sbjct: 231 GIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEA 278
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 80.9 bits (198), Expect = 6e-15
Identities = 67/194 (34%), Positives = 96/194 (49%), Gaps = 26/194 (13%)
Query: 383 KIDLKKGPEGLGFTVVTRDSSIH-GPGP-IFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440
+I L++G GLGF++ + H G P IF+ I+P GAA +DGRL+ D IL VN D
Sbjct: 98 EITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVD 157
Query: 441 VTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIP 500
V+ + + V L+ G L + R+ LET EI
Sbjct: 158 VSEVSHSKAVEALKEA--GSIVRLYVRRRRP----------------ILET----VVEIK 195
Query: 501 LNDSGSAGLGVSLKGNKSRE-TGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLL 559
L G GLG S+ G + D I++ II GGAA KDGRL++ D+L+ VN SL
Sbjct: 196 LF-KGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLE 254
Query: 560 GKSNHEAMETLRRS 573
++ EA+ L+ +
Sbjct: 255 EVTHEEAVAILKNT 268
Score = 66.6 bits (161), Expect = 1e-10
Identities = 37/79 (46%), Positives = 51/79 (64%), Gaps = 2/79 (2%)
Query: 382 IKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGDRILEVNGR 439
++I L KGP+GLGF++ + H PG I+V I+ GAA KDGRLQ GDR+L VN
Sbjct: 192 VEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNY 251
Query: 440 DVTGRTQEELVAMLRSTKQ 458
+ T EE VA+L++T +
Sbjct: 252 SLEEVTHEEAVAILKNTSE 270
Score = 60.1 bits (144), Expect = 1e-08
Identities = 42/119 (35%), Positives = 60/119 (50%), Gaps = 9/119 (7%)
Query: 491 TSEQLTFEIPLNDSGSAGLGVSLKGNKSR-ETGTDLGIFIKSIIHGGAAFKDGRLRMNDQ 549
T + FE + G++GLG S+ G G D GIFI II GGAA +DGRLR+ND
Sbjct: 90 TEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDC 149
Query: 550 LIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKP 608
++ VN + S+ +A+E L+ + G I + +RR +E E F P
Sbjct: 150 ILRVNEVDVSEVSHSKAVEALKEA--------GSIVRLYVRRRRPILETVVEIKLFKGP 200
Score = 57.4 bits (137), Expect = 7e-08
Identities = 49/137 (35%), Positives = 68/137 (49%), Gaps = 20/137 (14%)
Query: 383 KIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVT 442
K+ L KG GLGF +V + G G IFV IL G A G LQ GD+IL VNG D+
Sbjct: 421 KVVLHKGSTGLGFNIVGGED---GEG-IFVSFILAGGPADLSGELQRGDQILSVNGIDLR 476
Query: 443 GRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLN 502
G + E+ A L+ G+T +++ Q + E K + EQ+ +N
Sbjct: 477 GASHEQAAAALKGA--GQTVTIIAQYQPEDYARFEAKIH--------DLREQM-----MN 521
Query: 503 DSGSAGLGVSLKGNKSR 519
S S+G G SL+ N+ R
Sbjct: 522 HSMSSGSG-SLRTNQKR 537
Score = 47.8 bits (112), Expect = 6e-05
Identities = 26/67 (38%), Positives = 38/67 (56%), Gaps = 5/67 (7%)
Query: 505 GSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNH 564
GS GLG ++ G + E GIF+ I+ GG A G L+ DQ+++VNG L G S+
Sbjct: 427 GSTGLGFNIVGGEDGE-----GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHE 481
Query: 565 EAMETLR 571
+A L+
Sbjct: 482 QAAAALK 488
Score = 33.1 bits (74), Expect = 1.5
Identities = 13/48 (27%), Positives = 28/48 (58%)
Query: 230 GLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQA 277
G+FI I + +G N+CI+++N VD+ + + ++A + ++A
Sbjct: 126 GIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEA 173
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 80.1 bits (196), Expect = 1e-14
Identities = 63/255 (24%), Positives = 107/255 (41%), Gaps = 31/255 (12%)
Query: 338 SPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTV 397
+P+ ++S+S+ + P P + N N+ I + + G+ +V
Sbjct: 1336 TPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTVLFDKGGVNTSV 1395
Query: 398 VTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTK 457
G I+VK ++P+GAA DGR+ GDR+L VNG + G T ++ V LR+T
Sbjct: 1396 --------RHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNT- 1446
Query: 458 QGETASLVIARQEGHFLPRELKGEPDCCALSLE--------------------TSEQLTF 497
G+ L++ + + + P C +E+ TF
Sbjct: 1447 -GQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTF 1505
Query: 498 EIPL-NDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGE 556
E+ L +S G S + N E + +K + G A + G++ + D ++ VNG
Sbjct: 1506 EVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGA 1565
Query: 557 SLLGKSNHEAMETLR 571
SL G S E + LR
Sbjct: 1566 SLKGLSQQEVISALR 1580
Score = 57.4 bits (137), Expect = 7e-08
Identities = 66/315 (20%), Positives = 118/315 (37%), Gaps = 71/315 (22%)
Query: 204 VEISGEGGPLGIHVVPFFS----SLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINN 259
VE++ LGI V F + S R G++++ + ++ +G H+ + ++ +N
Sbjct: 1369 VELAKNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNG 1428
Query: 260 VDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVP 319
V L T QA + R + ++H+L + + K +
Sbjct: 1429 VSLEGATHKQAVETLRNTGQ----VVHLLLEKGQSPTSKEHV------------------ 1466
Query: 320 PPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNA 379
PV + L N G + + ++ F + +N
Sbjct: 1467 -PVTPQCTLSDQNAQGQGPEKVKKTTQVKD---------------------YSFVTEENT 1504
Query: 380 KKIKIDLKKGPEGLGFTVVTRDSSIH---GPGPIFVKNILPKGAAIKDGRLQSGDRILEV 436
++K L K GLGF+ D+ I + VK + P A + G++ GD IL+V
Sbjct: 1505 FEVK--LFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKV 1562
Query: 437 NGRDVTGRTQEELVAMLRST----------------KQGETASLVIARQEGHFLPRELK- 479
NG + G +Q+E+++ LR T + +TA L + LP K
Sbjct: 1563 NGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKD 1622
Query: 480 -GEPDCCALSLETSE 493
+P C S + E
Sbjct: 1623 SSQPSCVEQSTSSDE 1637
Score = 52.4 bits (124), Expect = 2e-06
Identities = 90/424 (21%), Positives = 159/424 (37%), Gaps = 72/424 (16%)
Query: 174 LEDREVLNGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRI-LGLF 232
L++ +VL+ + +++SP + TL ++ + + LG ++ GR+ LG+F
Sbjct: 1071 LKENDVLHK-RWSIVSSPEREITLVNLKKDAKYG-----LGFQIIG--GEKMGRLDLGIF 1122
Query: 233 IRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQA--------------- 277
I + + +G + ++ +N+V L + A ++ + A
Sbjct: 1123 ISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKI 1182
Query: 278 MKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNND------GVLKTKVPPPVHGKSGLKTA 331
K PS +H+ + S + I ++ G L+ GL+
Sbjct: 1183 SKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREG 1242
Query: 332 NLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSL--SPLMGFGSNKNAKKIKIDLKKG 389
+L+ DS AS S Q LG + S SP S K+ D
Sbjct: 1243 SLSSQDSRTESASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFTD---- 1298
Query: 390 PEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEEL 449
+ S PG V + +G + D S + +D QE
Sbjct: 1299 ---------SNQSKTKKPGISDVTDYSDRGDSDMDEATYS-------SSQDHQTPKQESS 1342
Query: 450 VAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSGSAGL 509
++ S K + G EL + +S+ L D G G+
Sbjct: 1343 SSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTV---------LFDKG--GV 1391
Query: 510 GVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMET 569
S++ GI++K++I GAA DGR+ D+++AVNG SL G ++ +A+ET
Sbjct: 1392 NTSVRHG---------GIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVET 1442
Query: 570 LRRS 573
LR +
Sbjct: 1443 LRNT 1446
Score = 49.7 bits (117), Expect = 2e-05
Identities = 73/286 (25%), Positives = 113/286 (39%), Gaps = 37/286 (12%)
Query: 381 KIKIDLKKGPEG-LGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGR 439
++ I L K +G LGFTV + I +V +++ + A DGRL+ GDR+++VN
Sbjct: 1791 ELLITLIKSEKGSLGFTVTKGNQRIG----CYVHDVI-QDPAKSDGRLKPGDRLIKVNDT 1845
Query: 440 DVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEI 499
DVT T + V +LR+ +T LVI R LPR + L +I
Sbjct: 1846 DVTNMTHTDAVNLLRAA--SKTVRLVIGRVLE--LPR------------IPMLPHLLPDI 1889
Query: 500 PLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLL 559
L LG SL G ++I I A +G L++ D + VNG S
Sbjct: 1890 TLT-CNKEELGFSLCGGHDSLYQV---VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQ 1945
Query: 560 GKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAE---------CGAFSKPCF 610
G + E L S+ L ++ +R + G+ S+P
Sbjct: 1946 GMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPAL 2005
Query: 611 ENCQNAVTTSRRNDNSILHPLGTCSPQD--KQKGLLLPNDGWAESE 654
+ T + N I +P G CS L LP + + + +
Sbjct: 2006 TPNDSFSTVAGEEINEISYPKGKCSTYQIKGSPNLTLPKESYIQED 2051
Score = 34.7 bits (78), Expect = 0.51
Identities = 29/107 (27%), Positives = 49/107 (45%), Gaps = 12/107 (11%)
Query: 490 ETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQ 549
E +L + ++ GS G V+ KGN+ +G ++ +I A DGRL+ D+
Sbjct: 1787 ELEVELLITLIKSEKGSLGFTVT-KGNQR------IGCYVHDVIQDPAK-SDGRLKPGDR 1838
Query: 550 LIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPM 596
LI VN + ++ +A+ LR + + G +L P PM
Sbjct: 1839 LIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR----VLELPRIPM 1881
Score = 33.1 bits (74), Expect = 1.5
Identities = 35/122 (28%), Positives = 53/122 (43%), Gaps = 22/122 (18%)
Query: 332 NLTGTDSPETDASAS----LQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLK 387
N+T TD+ +AS L + +PR+ P P L P + NK
Sbjct: 1849 NMTHTDAVNLLRAASKTVRLVIGRVLELPRI---PMLPHLLPDITLTCNK---------- 1895
Query: 388 KGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQE 447
E LGF++ S++ +++ +I P+ A +G LQ D I VNG G T E
Sbjct: 1896 ---EELGFSLCGGHDSLYQV--VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLE 1950
Query: 448 EL 449
E+
Sbjct: 1951 EV 1952
>gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens]
Length = 728
Score = 79.7 bits (195), Expect = 1e-14
Identities = 77/276 (27%), Positives = 129/276 (46%), Gaps = 48/276 (17%)
Query: 349 QNKSPRVPRLGGKPSSPSLSPLMGFGSNK--------NAKKIKIDLKKGP-EGLGFTVVT 399
+ +SP + + G S+ S SP G SN + ++++K P E LG TV
Sbjct: 465 RQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAG 524
Query: 400 RDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQG 459
S PI+V ++ P G +DGR+++GD +L V+G ++T ++ E VA+L+ T
Sbjct: 525 GASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRT--- 581
Query: 460 ETASLVIARQEGHFLPRELKGEPDCCA-LSLETSEQLT------------FEIP------ 500
++S+V+ E +E + + DC + +L+++ + E+P
Sbjct: 582 -SSSIVLKALE----VKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNC 636
Query: 501 ----LNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGE 556
L + + LG + G G + FIKSI+ G A+ DGR+R D L+AVNG
Sbjct: 637 KDIVLRRNTAGSLGFCIVGGYEEYNG-NKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGR 695
Query: 557 SLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRP 592
S G H + L + ++G I L I+ P
Sbjct: 696 STSGMI-HACLARLLK------ELKGRITLTIVSWP 724
Score = 62.8 bits (151), Expect = 2e-09
Identities = 60/226 (26%), Positives = 95/226 (42%), Gaps = 24/226 (10%)
Query: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469
I +++I G +DGRL GD IL+VNG D++ V +LR Q L + R+
Sbjct: 301 IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQ--VLWLTVMRE 358
Query: 470 EGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSG-SAGLGVSLKGNKSRETGTDLGIF 528
+ F R PD +F + LN S LG+ L G+F
Sbjct: 359 Q-KFRSRNNGQAPDAYR-----PRDDSFHVILNKSSPEEQLGIKLVRKVDEP-----GVF 407
Query: 529 IKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVI 588
I +++ GG A++ G+L ND+++A+NG L S A ++ S + LV+
Sbjct: 408 IFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQAS-------ERRVHLVV 460
Query: 589 LRRPERPMEDPAECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTC 634
R+ + D + ++ + R N LHP TC
Sbjct: 461 SRQVRQRSPDIFQEAGWNS---NGSWSPGPGERSNTPKPLHPTITC 503
>gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens]
Length = 632
Score = 79.7 bits (195), Expect = 1e-14
Identities = 77/276 (27%), Positives = 129/276 (46%), Gaps = 48/276 (17%)
Query: 349 QNKSPRVPRLGGKPSSPSLSPLMGFGSNK--------NAKKIKIDLKKGP-EGLGFTVVT 399
+ +SP + + G S+ S SP G SN + ++++K P E LG TV
Sbjct: 369 RQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAG 428
Query: 400 RDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQG 459
S PI+V ++ P G +DGR+++GD +L V+G ++T ++ E VA+L+ T
Sbjct: 429 GASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRT--- 485
Query: 460 ETASLVIARQEGHFLPRELKGEPDCCA-LSLETSEQLT------------FEIP------ 500
++S+V+ E +E + + DC + +L+++ + E+P
Sbjct: 486 -SSSIVLKALE----VKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNC 540
Query: 501 ----LNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGE 556
L + + LG + G G + FIKSI+ G A+ DGR+R D L+AVNG
Sbjct: 541 KDIVLRRNTAGSLGFCIVGGYEEYNG-NKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGR 599
Query: 557 SLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRP 592
S G H + L + ++G I L I+ P
Sbjct: 600 STSGMI-HACLARLLK------ELKGRITLTIVSWP 628
Score = 62.8 bits (151), Expect = 2e-09
Identities = 60/226 (26%), Positives = 95/226 (42%), Gaps = 24/226 (10%)
Query: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469
I +++I G +DGRL GD IL+VNG D++ V +LR Q L + R+
Sbjct: 205 IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQ--VLWLTVMRE 262
Query: 470 EGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSG-SAGLGVSLKGNKSRETGTDLGIF 528
+ F R PD +F + LN S LG+ L G+F
Sbjct: 263 Q-KFRSRNNGQAPDAYR-----PRDDSFHVILNKSSPEEQLGIKLVRKVDEP-----GVF 311
Query: 529 IKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVI 588
I +++ GG A++ G+L ND+++A+NG L S A ++ S + LV+
Sbjct: 312 IFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQAS-------ERRVHLVV 364
Query: 589 LRRPERPMEDPAECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTC 634
R+ + D + ++ + R N LHP TC
Sbjct: 365 SRQVRQRSPDIFQEAGWNS---NGSWSPGPGERSNTPKPLHPTITC 407
>gi|87196343 PDZ domain containing 2 [Homo sapiens]
Length = 2839
Score = 74.7 bits (182), Expect = 4e-13
Identities = 56/198 (28%), Positives = 96/198 (48%), Gaps = 16/198 (8%)
Query: 387 KKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQ 446
+K GLGF+V + P I V + +GAA ++G + GD +L VNG + G
Sbjct: 2627 RKEGSGLGFSVA--GGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAH 2684
Query: 447 EELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFE------IP 500
++ +L + + A +VI + P + P L + + + E +
Sbjct: 2685 GNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRSVA 2744
Query: 501 LNDS-------GSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAV 553
++D+ SAGLG+SL G KS TG D + IK + GGAA + G + D+++A+
Sbjct: 2745 VHDALCVEVLKTSAGLGLSLDGGKSSVTG-DGPLVIKRVYKGGAAEQAGIIEAGDEILAI 2803
Query: 554 NGESLLGKSNHEAMETLR 571
NG+ L+G + +A ++
Sbjct: 2804 NGKPLVGLMHFDAWNIMK 2821
Score = 68.9 bits (167), Expect = 2e-11
Identities = 115/489 (23%), Positives = 190/489 (38%), Gaps = 93/489 (19%)
Query: 387 KKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQ 446
K+ +GLGF++ I G IFVK I P G+A +DGRL+ GD IL+VNG + G T
Sbjct: 591 KEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTF 650
Query: 447 EELVAMLRSTKQGETASLVIARQEGHFL-----PREL------------------KGEPD 483
+E + + + G V + L P + E
Sbjct: 651 QEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGS 710
Query: 484 CCALSLET---SEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFK 540
+L +T +++ E+ LN GLG+ + GI+I S+ G A
Sbjct: 711 SSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPP--GIYIHSLAPGSVAKM 768
Query: 541 DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA 600
+ L DQ++ VN ++ H A+ + +S G ++LVI R P + +
Sbjct: 769 ESNLSRGDQILEVNSVNV----RHAALSKVHAILSK--CPPGPVRLVIGRHPNPKVSEQE 822
Query: 601 ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGT--CSPQDKQKGLLLPNDGWAESEVPPS 658
++ ++ + A ++ LGT SP +K L+ ++
Sbjct: 823 MDEVIARSTYQESKEANSSP---------GLGTPLKSPSLAKKDSLISESELSQYFAHDV 873
Query: 659 PTPHS-ALGLGLEDYSH-SSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPD 716
P P S + G ED H SG ++ E +L S S P
Sbjct: 874 PGPLSDFMVAGSEDEDHPGSGCSTS-------------------EEGSLPPSTSTHKEPG 914
Query: 717 ESKVHSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPF--HRPRPHMVRG 774
+ + +SL TLG ++S L Q VA R+ LP R ++R
Sbjct: 915 KPRANSLV-------------TLGSHRASGLFHKQVTVA--RQASLPGSPQALRNPLLRQ 959
Query: 775 R--GCNESFRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQ----GNSELEDME 828
R GC ++ A+ ++ +D E D +S + G E P+ +S+ D+
Sbjct: 960 RKVGCYDANDASDEEEFDR----EGDCISLPGALPGPIRPLSEDDPRRVSISSSKGMDVH 1015
Query: 829 NKARKVKKT 837
N+ + +KT
Sbjct: 1016 NQEERPRKT 1024
Score = 57.4 bits (137), Expect = 7e-08
Identities = 47/133 (35%), Positives = 65/133 (48%), Gaps = 9/133 (6%)
Query: 339 PETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKI-KIDLKKGPEGLGFTV 397
P+TDA + +K R GGK S L + + +I K++L K +GLG V
Sbjct: 295 PKTDAPLTTSNDK--RRFSKGGKTDFQSSDCL----AREEVGRIWKMELLKESDGLGIQV 348
Query: 398 VTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTK 457
S P I V + GAA +DGRL GD +L +NG + G + EE VA+LRS
Sbjct: 349 SGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSAT 408
Query: 458 QGETASLVIARQE 470
LV+A +E
Sbjct: 409 --GMVQLVVASKE 419
Score = 56.6 bits (135), Expect = 1e-07
Identities = 37/120 (30%), Positives = 61/120 (50%), Gaps = 9/120 (7%)
Query: 506 SAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHE 565
S GLG+ + G + + I + + GGAA +DGRL + D+L+ +NG L+G S+ E
Sbjct: 341 SDGLGIQVSGGRGSKRSPH-AIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEE 399
Query: 566 AMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKPCFENCQNAVTTSRRNDN 625
A+ LR + GM+QLV+ + E ED + S P + V++ N++
Sbjct: 400 AVAILR-------SATGMVQLVVASK-ENSAEDLLRLTSKSLPDLTSSVEDVSSWTDNED 451
Score = 50.4 bits (119), Expect = 9e-06
Identities = 24/82 (29%), Positives = 46/82 (56%)
Query: 384 IDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTG 443
+++ K GLG ++ SS+ G GP+ +K + GAA + G +++GD IL +NG+ + G
Sbjct: 2751 VEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVG 2810
Query: 444 RTQEELVAMLRSTKQGETASLV 465
+ +++S +G L+
Sbjct: 2811 LMHFDAWNIMKSVPEGPVQLLI 2832
Score = 50.1 bits (118), Expect = 1e-05
Identities = 71/311 (22%), Positives = 120/311 (38%), Gaps = 59/311 (18%)
Query: 209 EGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFA 268
+G LG + + G+ +G+F++ I N + +G E + I+ +N + + TF
Sbjct: 593 KGKGLGFSIAGGRDCIRGQ-MGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQ 651
Query: 269 QAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGL 328
+A F+Q VL ++TK+ P
Sbjct: 652 EAIHTFKQIRSGLFVL----------------------------TVRTKLVSPSLTPCST 683
Query: 329 KTANLTGTDSPE--TDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDL 386
T +++ + SP T AS + LG K P K+ +++ L
Sbjct: 684 PT-HMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPGP-----------KDRIVMEVTL 731
Query: 387 KKGPE---GLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTG 443
K P G+G + ++S P I++ ++ P A + L GD+ILEVN +V
Sbjct: 732 NKEPRVGLGIGACCLALENS---PPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRH 788
Query: 444 RTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLND 503
++ A+L G LVI R H P+ + E D E + T++
Sbjct: 789 AALSKVHAILSKCPPG-PVRLVIGR---HPNPKVSEQEMD------EVIARSTYQESKEA 838
Query: 504 SGSAGLGVSLK 514
+ S GLG LK
Sbjct: 839 NSSPGLGTPLK 849
Score = 41.2 bits (95), Expect = 0.005
Identities = 33/117 (28%), Positives = 55/117 (47%), Gaps = 10/117 (8%)
Query: 490 ETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDL---GIFIKSIIHGGAAFKDGRLRM 546
E E + F I LN +GLG S+ G GTD+ I + + GAA ++G +
Sbjct: 2615 ENEEDVCF-IVLNRKEGSGLGFSVAG------GTDVEPKSITVHRVFSQGAASQEGTMNR 2667
Query: 547 NDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECG 603
D L++VNG SL G ++ ++ L ++ + + + + + RP E P G
Sbjct: 2668 GDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANG 2724
Score = 33.1 bits (74), Expect = 1.5
Identities = 23/87 (26%), Positives = 44/87 (50%), Gaps = 10/87 (11%)
Query: 510 GVSLKGNKSRETGT----DLG-IFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNH 564
G +G K R+T D+G I++ + A K G++R+ D+++++NG+ ++G
Sbjct: 97 GEKRRGGKKRKTHQGPVLDVGCIWVTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVS 156
Query: 565 EAMETLRRSMSMEGNIRGMIQLVILRR 591
A + + G I L++LRR
Sbjct: 157 GASYLAEQCWN-----GGFIYLIMLRR 178
>gi|218505835 membrane-associated guanylate kinase-related 3 isoform
1 [Homo sapiens]
Length = 1481
Score = 72.8 bits (177), Expect = 2e-12
Identities = 146/697 (20%), Positives = 256/697 (36%), Gaps = 159/697 (22%)
Query: 335 GTDSPETDASASL--QQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEG 392
G PE D+S + QN SPR+ R P+ P+ + + + K+ EG
Sbjct: 813 GEKQPEDDSSQAFISTQNGSPRLNR-AEVPARPA---------PQEPYDVVLQRKEN-EG 861
Query: 393 LGFTVVT-RDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVA 451
GF ++T ++ G P + ++ A + G+L+ GD I VNG+ + + + +V
Sbjct: 862 FGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQ 921
Query: 452 MLRSTKQGETASLVIARQEGHFLPRE------------------------------LKGE 481
+++ G T +L + +E H P L+GE
Sbjct: 922 LIKDA--GVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGE 979
Query: 482 ---------------------PDCCALSLETSEQLT----FEIPLNDSGSAGLGVSLKGN 516
PD +S+ S + + L + G G G SL+G
Sbjct: 980 IGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVEL-ERGPRGFGFSLRGG 1038
Query: 517 KSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSM 576
K ++G+FI + G A KDGR+ + DQ++ +NGE G ++ A+E ++ +
Sbjct: 1039 KEY----NMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNK 1094
Query: 577 ----------------EGNIRGMIQLVILRRPERPMEDPAECGAFSK----PCFENCQNA 616
+ +I ++ + P+ + + + P E
Sbjct: 1095 VLLLLRPGTGLIPDHGDWDINNPSSSNVIYDEQSPLPPSSHFASIFEESHVPVIEESLRV 1154
Query: 617 VTTSRRNDNSILHP-----LGTCSPQDKQKGLLLPNDGWAESEVPPSPTPHSALGLGLED 671
+ + + P L P+ K + LL N PPS HS +
Sbjct: 1155 QICEKAEELKDIVPEKKSTLNENQPEIKHQSLLQKN---VSKRDPPSSHGHS-------N 1204
Query: 672 YSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKVHSLAGQKSESP 731
+ V++ V RSV+P ++P S + + + +D +P K + + +S
Sbjct: 1205 KKNLLKVENGV-----TRRGRSVSP-KKPASQH--SEEHLDKIPSPLKNNPKRRPRDQSL 1256
Query: 732 SKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNESFRAAIDKSYDG 791
S G + S+ S Q + RK+ RGR + + I+ S
Sbjct: 1257 SPSKGENKSCQVSTRAGSGQD---QCRKS------------RGRSASPKKQQKIEGS-KA 1300
Query: 792 PEEIEADGLSDKSSH-SGQGALNCESAPQGNSELEDMENKARKVKKTKEKEKKKEKGKLK 850
P EA L KS +G N E P G + + + A++ + K + + EK +
Sbjct: 1301 PSNAEAKLLEGKSRRIAGYTGSNAEQIPDGKEKSDVIRKDAKQNQLEKSRTRSPEKKIKR 1360
Query: 851 VKEK------------KRKEENE--------DPERKIKKKGFGAMLRFGKKKEDKGGKAE 890
+ EK K ENE + K G L + K++ K
Sbjct: 1361 MVEKSLPSKMTNKTTSKEVSENEKGKKVTTGETSSSNDKIGENVQLSEKRLKQEPEEKVV 1420
Query: 891 QKGTLKHGGLREEELEKMKEERESGRPTGGSTDRIQK 927
T H G +ELE + +E+GR S+ ++K
Sbjct: 1421 SNKTEDHKG---KELEAADKNKETGRFKPESSSPVKK 1454
Score = 69.3 bits (168), Expect = 2e-11
Identities = 67/273 (24%), Positives = 125/273 (45%), Gaps = 34/273 (12%)
Query: 326 SGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPS-----SPSLSPLMGFGSNK--- 377
S KTA + TD E + SL+ P + PS SP L P + +K
Sbjct: 659 SPTKTAKMK-TDKKEN--AGSLEAINEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLY 715
Query: 378 -----NAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGP-IFVKNILPKGAAIKDGRLQSGD 431
N K + + L+K G GF V+ D GP I++ I+P GAA KDGRL++ D
Sbjct: 716 EDKPPNTKDLDVFLRKQESGFGFRVLGGD----GPDQSIYIGAIIPLGAAEKDGRLRAAD 771
Query: 432 RILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ--EGHFLPRE---------LKG 480
++ ++G V G++ ++++ ++ + + L + R+ G P + G
Sbjct: 772 ELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNG 831
Query: 481 EP--DCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAA 538
P + + + Q +++ L + G G + +K++ + I +I G A
Sbjct: 832 SPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPA 891
Query: 539 FKDGRLRMNDQLIAVNGESLLGKSNHEAMETLR 571
+ G+L++ D + AVNG+S++ S+ ++ ++
Sbjct: 892 DRCGKLKVGDHISAVNGQSIVELSHDNIVQLIK 924
Score = 53.9 bits (128), Expect = 8e-07
Identities = 31/94 (32%), Positives = 50/94 (53%), Gaps = 5/94 (5%)
Query: 382 IKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDV 441
++ LKK G GFT++ D + VKN+L G A +DG++ GD I+++NG V
Sbjct: 409 VRASLKKSTMGFGFTIIGGDRPDEF---LQVKNVLKDGPAAQDGKIAPGDVIVDINGNCV 465
Query: 442 TGRTQEELVAMLRSTKQGETASLVIARQEGHFLP 475
G T ++V M + + +L + R G+ LP
Sbjct: 466 LGHTHADVVQMFQLVPVNQYVNLTLCR--GYPLP 497
Score = 53.5 bits (127), Expect = 1e-06
Identities = 75/322 (23%), Positives = 123/322 (38%), Gaps = 50/322 (15%)
Query: 320 PPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRV---PRLGGKPSSPSLSPLMGFGSN 376
P ++G+S K + A Q KS L G + M +
Sbjct: 512 PVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGS 571
Query: 377 KNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEV 436
+ + I L KGP+G GF + P VK IL LQ GD I E+
Sbjct: 572 SQPELVTIPLIKGPKGFGFAIAD------SPTGQKVKMILDSQWC---QGLQKGDIIKEI 622
Query: 437 NGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPD-------CCALSL 489
++V T ++V +L+ G L+I R + K + D A++
Sbjct: 623 YHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINE 682
Query: 490 ETSEQLTFEIPLNDSGSAGLGVSLKGNKSRET---------------------------- 521
+ + F + SGS L S KS+
Sbjct: 683 PIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLG 742
Query: 522 --GTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGN 579
G D I+I +II GAA KDGRLR D+L+ ++G + GKS+ + ++ L + + G+
Sbjct: 743 GDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLD-LMTTAARNGH 801
Query: 580 IRGMIQLVILRRPERPMEDPAE 601
+ ++ I ++P +D ++
Sbjct: 802 VLLTVRRKIFYGEKQPEDDSSQ 823
Score = 31.2 bits (69), Expect = 5.7
Identities = 10/40 (25%), Positives = 26/40 (65%)
Query: 529 IKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAME 568
+K+++ G A +DG++ D ++ +NG +LG ++ + ++
Sbjct: 436 VKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQ 475
>gi|27262655 interleukin 16 isoform 1 precursor [Homo sapiens]
Length = 631
Score = 71.2 bits (173), Expect = 5e-12
Identities = 51/198 (25%), Positives = 94/198 (47%), Gaps = 15/198 (7%)
Query: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469
I V + P G A ++G +Q G+ +L +NG+ + G T + +A+LR ++ A +V +
Sbjct: 438 ITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKL 497
Query: 470 EGHFLPRELKGEPDCCA-------LSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETG 522
+P +L D A +S+E++ + T + SAGLG SL+G K G
Sbjct: 498 TPEAMP-DLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHG 556
Query: 523 TDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRG 582
D + I I G A+ + ++ D+++ + G ++ G + EA ++ G
Sbjct: 557 -DKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPD------G 609
Query: 583 MIQLVILRRPERPMEDPA 600
+ +VI R+ + E A
Sbjct: 610 PVTIVIRRKSLQSKETTA 627
Score = 46.2 bits (108), Expect = 2e-04
Identities = 36/144 (25%), Positives = 63/144 (43%), Gaps = 17/144 (11%)
Query: 342 DASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG----------------SNKNAKKIKID 385
DA A L+Q + PR + + +P P + S A +
Sbjct: 476 DALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVT 535
Query: 386 LKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRT 445
L+K GLGF++ S+HG P+ + I A+ + +Q GD IL++ G + G T
Sbjct: 536 LEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLT 595
Query: 446 QEELVAMLRSTKQGETASLVIARQ 469
+ E ++++ G ++VI R+
Sbjct: 596 RFEAWNIIKALPDG-PVTIVIRRK 618
>gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo
sapiens]
Length = 1287
Score = 70.9 bits (172), Expect = 6e-12
Identities = 93/379 (24%), Positives = 152/379 (40%), Gaps = 64/379 (16%)
Query: 230 GLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLP 289
G+FI I +++ I+ +N++ L TF A R SP
Sbjct: 780 GIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMA---VRMIQNSP-------- 828
Query: 290 PQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQ 349
+ E + S + GNN K SG+ + ++ + S + Q
Sbjct: 829 ----DNIELIISQSKGVGGNNPDEEKNST-----ANSGVSSTDILSFGYQGSLLSHTQDQ 879
Query: 350 NKSPRVPRLGGKPS-------SPSLSPLMGFGSNKNAKKIKI--------DLKKGPEGLG 394
+++ + G S S PL G GS+ +I +L K LG
Sbjct: 880 DRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTLG 939
Query: 395 FTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLR 454
F+V ++ G I+VK+I+P G A K+G++ GDR+L+V+G + G T ++ V L
Sbjct: 940 FSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCL- 998
Query: 455 STKQGETASLVIAR-------------------QEGHFLPRELKGEPDCCALSLETSEQL 495
T G+ A LV+ R + L L G P C + ++
Sbjct: 999 -TGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSC---VSVTDGP 1054
Query: 496 TFEIPLNDSGSAGLG---VSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIA 552
FE+ L + + GLG V ++ +DL + IK + G A ++G + D ++A
Sbjct: 1055 KFEVKLKKNAN-GLGFSFVQMEKESCSHLKSDL-VRIKRLFPGQPAEENGAIAAGDIILA 1112
Query: 553 VNGESLLGKSNHEAMETLR 571
VNG S G E + LR
Sbjct: 1113 VNGRSTEGLIFQEVLHLLR 1131
Score = 54.3 bits (129), Expect = 6e-07
Identities = 82/334 (24%), Positives = 132/334 (39%), Gaps = 71/334 (21%)
Query: 204 VEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLV 263
VE+ E G LG V ++ S G++++ I + +EG + + +++++ V L
Sbjct: 929 VELVKEDGTLGFSVTGGINT-SVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILC 987
Query: 264 DKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVH 323
T QA Q + P + + VL+ +VP
Sbjct: 988 GLTHKQAV----QCLTGPGQVARL-------------------------VLERRVPRSTQ 1018
Query: 324 GKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIK 383
P + S ++ V L G+PSS S + K +
Sbjct: 1019 -------------QCPSANDSMGDERTAVSLVTALPGRPSSCV--------SVTDGPKFE 1057
Query: 384 IDLKKGPEGLGFTVVT--RDSSIHGPGPIF-VKNILPKGAAIKDGRLQSGDRILEVNGRD 440
+ LKK GLGF+ V ++S H + +K + P A ++G + +GD IL VNGR
Sbjct: 1058 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 1117
Query: 441 VTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLE---------- 490
G +E++ +LR Q T L++ R LP EL+ E LS +
Sbjct: 1118 TEGLIFQEVLHLLRGAPQEVT--LLLCRPPPGALP-ELEQEWQTPELSADKEFTRATCTD 1174
Query: 491 --TSEQLTFEIPLNDSGS--AGLGVSLKGNKSRE 520
TS L E DS S AG G+ L+ S++
Sbjct: 1175 SCTSPILDQEDSWRDSASPDAGEGLGLRPESSQK 1208
Score = 40.8 bits (94), Expect = 0.007
Identities = 30/112 (26%), Positives = 54/112 (48%), Gaps = 13/112 (11%)
Query: 371 MGFGSNKNAKK----------IKIDLKKGPE-GLGFTVVTRDSSIHGPGPIFVKNILPKG 419
M GS N +K +++ LK+ P G GF + + S IF+ +I+P G
Sbjct: 731 MHAGSKNNRRKSFIAEPGREIVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGG 790
Query: 420 AAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEG 471
A K ++ G +IL +N + G T V M++++ + L+I++ +G
Sbjct: 791 PAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSP--DNIELIISQSKG 840
Score = 37.7 bits (86), Expect = 0.060
Identities = 52/188 (27%), Positives = 81/188 (43%), Gaps = 18/188 (9%)
Query: 524 DLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGM 583
D GIFI SII GG A K ++ Q++A+N SL G + + A+ ++ S I
Sbjct: 778 DPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELIISQ 837
Query: 584 IQLVILRRPERPMEDPAECGAFSKPC----FENCQNAVTTSRRNDNSILHPLGTCS--PQ 637
+ V P+ A G S ++ + T + + L G S P+
Sbjct: 838 SKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSHTQDQDRNTEELDMAGVQSLVPR 897
Query: 638 DKQKGLLLPNDGWAESEVPPSPTPHSA-----LGLGLED----YSHSSGVDSAVYFPDQH 688
+ + LP G A S PPSP SA + L ED +S + G++++V P
Sbjct: 898 LRHQLSFLPLKG-AGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSV--PYGG 954
Query: 689 INFRSVTP 696
I +S+ P
Sbjct: 955 IYVKSIVP 962
>gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo
sapiens]
Length = 1309
Score = 70.9 bits (172), Expect = 6e-12
Identities = 93/379 (24%), Positives = 152/379 (40%), Gaps = 64/379 (16%)
Query: 230 GLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLP 289
G+FI I +++ I+ +N++ L TF A R SP
Sbjct: 802 GIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMA---VRMIQNSP-------- 850
Query: 290 PQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQ 349
+ E + S + GNN K SG+ + ++ + S + Q
Sbjct: 851 ----DNIELIISQSKGVGGNNPDEEKNST-----ANSGVSSTDILSFGYQGSLLSHTQDQ 901
Query: 350 NKSPRVPRLGGKPS-------SPSLSPLMGFGSNKNAKKIKI--------DLKKGPEGLG 394
+++ + G S S PL G GS+ +I +L K LG
Sbjct: 902 DRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTLG 961
Query: 395 FTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLR 454
F+V ++ G I+VK+I+P G A K+G++ GDR+L+V+G + G T ++ V L
Sbjct: 962 FSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCL- 1020
Query: 455 STKQGETASLVIAR-------------------QEGHFLPRELKGEPDCCALSLETSEQL 495
T G+ A LV+ R + L L G P C + ++
Sbjct: 1021 -TGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSC---VSVTDGP 1076
Query: 496 TFEIPLNDSGSAGLG---VSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIA 552
FE+ L + + GLG V ++ +DL + IK + G A ++G + D ++A
Sbjct: 1077 KFEVKLKKNAN-GLGFSFVQMEKESCSHLKSDL-VRIKRLFPGQPAEENGAIAAGDIILA 1134
Query: 553 VNGESLLGKSNHEAMETLR 571
VNG S G E + LR
Sbjct: 1135 VNGRSTEGLIFQEVLHLLR 1153
Score = 54.3 bits (129), Expect = 6e-07
Identities = 82/334 (24%), Positives = 132/334 (39%), Gaps = 71/334 (21%)
Query: 204 VEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLV 263
VE+ E G LG V ++ S G++++ I + +EG + + +++++ V L
Sbjct: 951 VELVKEDGTLGFSVTGGINT-SVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILC 1009
Query: 264 DKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVH 323
T QA Q + P + + VL+ +VP
Sbjct: 1010 GLTHKQAV----QCLTGPGQVARL-------------------------VLERRVPRSTQ 1040
Query: 324 GKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIK 383
P + S ++ V L G+PSS S + K +
Sbjct: 1041 -------------QCPSANDSMGDERTAVSLVTALPGRPSSCV--------SVTDGPKFE 1079
Query: 384 IDLKKGPEGLGFTVVT--RDSSIHGPGPIF-VKNILPKGAAIKDGRLQSGDRILEVNGRD 440
+ LKK GLGF+ V ++S H + +K + P A ++G + +GD IL VNGR
Sbjct: 1080 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 1139
Query: 441 VTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLE---------- 490
G +E++ +LR Q T L++ R LP EL+ E LS +
Sbjct: 1140 TEGLIFQEVLHLLRGAPQEVT--LLLCRPPPGALP-ELEQEWQTPELSADKEFTRATCTD 1196
Query: 491 --TSEQLTFEIPLNDSGS--AGLGVSLKGNKSRE 520
TS L E DS S AG G+ L+ S++
Sbjct: 1197 SCTSPILDQEDSWRDSASPDAGEGLGLRPESSQK 1230
Score = 40.8 bits (94), Expect = 0.007
Identities = 30/112 (26%), Positives = 54/112 (48%), Gaps = 13/112 (11%)
Query: 371 MGFGSNKNAKK----------IKIDLKKGPE-GLGFTVVTRDSSIHGPGPIFVKNILPKG 419
M GS N +K +++ LK+ P G GF + + S IF+ +I+P G
Sbjct: 753 MHAGSKNNRRKSFIAEPGREIVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGG 812
Query: 420 AAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEG 471
A K ++ G +IL +N + G T V M++++ + L+I++ +G
Sbjct: 813 PAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSP--DNIELIISQSKG 862
Score = 37.7 bits (86), Expect = 0.060
Identities = 52/188 (27%), Positives = 81/188 (43%), Gaps = 18/188 (9%)
Query: 524 DLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGM 583
D GIFI SII GG A K ++ Q++A+N SL G + + A+ ++ S I
Sbjct: 800 DPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELIISQ 859
Query: 584 IQLVILRRPERPMEDPAECGAFSKPC----FENCQNAVTTSRRNDNSILHPLGTCS--PQ 637
+ V P+ A G S ++ + T + + L G S P+
Sbjct: 860 SKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSHTQDQDRNTEELDMAGVQSLVPR 919
Query: 638 DKQKGLLLPNDGWAESEVPPSPTPHSA-----LGLGLED----YSHSSGVDSAVYFPDQH 688
+ + LP G A S PPSP SA + L ED +S + G++++V P
Sbjct: 920 LRHQLSFLPLKG-AGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSV--PYGG 976
Query: 689 INFRSVTP 696
I +S+ P
Sbjct: 977 IYVKSIVP 984
>gi|155969695 membrane-associated guanylate kinase-related 3
isoform 2 [Homo sapiens]
Length = 1125
Score = 69.3 bits (168), Expect = 2e-11
Identities = 67/273 (24%), Positives = 125/273 (45%), Gaps = 34/273 (12%)
Query: 326 SGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPS-----SPSLSPLMGFGSNK--- 377
S KTA + TD E + SL+ P + PS SP L P + +K
Sbjct: 659 SPTKTAKMK-TDKKEN--AGSLEAINEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLY 715
Query: 378 -----NAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGP-IFVKNILPKGAAIKDGRLQSGD 431
N K + + L+K G GF V+ D GP I++ I+P GAA KDGRL++ D
Sbjct: 716 EDKPPNTKDLDVFLRKQESGFGFRVLGGD----GPDQSIYIGAIIPLGAAEKDGRLRAAD 771
Query: 432 RILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ--EGHFLPRE---------LKG 480
++ ++G V G++ ++++ ++ + + L + R+ G P + G
Sbjct: 772 ELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNG 831
Query: 481 EP--DCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAA 538
P + + + Q +++ L + G G + +K++ + I +I G A
Sbjct: 832 SPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPA 891
Query: 539 FKDGRLRMNDQLIAVNGESLLGKSNHEAMETLR 571
+ G+L++ D + AVNG+S++ S+ ++ ++
Sbjct: 892 DRCGKLKVGDHISAVNGQSIVELSHDNIVQLIK 924
Score = 64.7 bits (156), Expect = 5e-10
Identities = 69/295 (23%), Positives = 120/295 (40%), Gaps = 76/295 (25%)
Query: 335 GTDSPETDASASL--QQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEG 392
G PE D+S + QN SPR+ R P+ P+ + + + K+ EG
Sbjct: 813 GEKQPEDDSSQAFISTQNGSPRLNR-AEVPARPA---------PQEPYDVVLQRKEN-EG 861
Query: 393 LGFTVVT-RDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVA 451
GF ++T ++ G P + ++ A + G+L+ GD I VNG+ + + + +V
Sbjct: 862 FGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQ 921
Query: 452 MLRSTKQGETASLVIARQEGHFLPRE------------------------------LKGE 481
+++ G T +L + +E H P L+GE
Sbjct: 922 LIKDA--GVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGE 979
Query: 482 ---------------------PDCCALSLETSEQLT----FEIPLNDSGSAGLGVSLKGN 516
PD +S+ S + + L + G G G SL+G
Sbjct: 980 IGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVEL-ERGPRGFGFSLRGG 1038
Query: 517 KSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLR 571
K ++G+FI + G A KDGR+ + DQ++ +NGE G ++ A+E ++
Sbjct: 1039 KEY----NMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQ 1089
Score = 53.9 bits (128), Expect = 8e-07
Identities = 31/94 (32%), Positives = 50/94 (53%), Gaps = 5/94 (5%)
Query: 382 IKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDV 441
++ LKK G GFT++ D + VKN+L G A +DG++ GD I+++NG V
Sbjct: 409 VRASLKKSTMGFGFTIIGGDRPDEF---LQVKNVLKDGPAAQDGKIAPGDVIVDINGNCV 465
Query: 442 TGRTQEELVAMLRSTKQGETASLVIARQEGHFLP 475
G T ++V M + + +L + R G+ LP
Sbjct: 466 LGHTHADVVQMFQLVPVNQYVNLTLCR--GYPLP 497
Score = 53.9 bits (128), Expect = 8e-07
Identities = 27/86 (31%), Positives = 49/86 (56%), Gaps = 3/86 (3%)
Query: 370 LMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQS 429
++G N+N ++L++GP G GF++ R + G +F+ + G AIKDGR+
Sbjct: 1008 VVGSRHNQNLGCYPVELERGPRGFGFSL--RGGKEYNMG-LFILRLAEDGPAIKDGRIHV 1064
Query: 430 GDRILEVNGRDVTGRTQEELVAMLRS 455
GD+I+E+NG G T + ++++
Sbjct: 1065 GDQIVEINGEPTQGITHTRAIELIQA 1090
Score = 53.5 bits (127), Expect = 1e-06
Identities = 75/322 (23%), Positives = 123/322 (38%), Gaps = 50/322 (15%)
Query: 320 PPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRV---PRLGGKPSSPSLSPLMGFGSN 376
P ++G+S K + A Q KS L G + M +
Sbjct: 512 PVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGS 571
Query: 377 KNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEV 436
+ + I L KGP+G GF + P VK IL LQ GD I E+
Sbjct: 572 SQPELVTIPLIKGPKGFGFAIAD------SPTGQKVKMILDSQWC---QGLQKGDIIKEI 622
Query: 437 NGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPD-------CCALSL 489
++V T ++V +L+ G L+I R + K + D A++
Sbjct: 623 YHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINE 682
Query: 490 ETSEQLTFEIPLNDSGSAGLGVSLKGNKSRET---------------------------- 521
+ + F + SGS L S KS+
Sbjct: 683 PIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLG 742
Query: 522 --GTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGN 579
G D I+I +II GAA KDGRLR D+L+ ++G + GKS+ + ++ L + + G+
Sbjct: 743 GDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLD-LMTTAARNGH 801
Query: 580 IRGMIQLVILRRPERPMEDPAE 601
+ ++ I ++P +D ++
Sbjct: 802 VLLTVRRKIFYGEKQPEDDSSQ 823
Score = 31.2 bits (69), Expect = 5.7
Identities = 10/40 (25%), Positives = 26/40 (65%)
Query: 529 IKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAME 568
+K+++ G A +DG++ D ++ +NG +LG ++ + ++
Sbjct: 436 VKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQ 475
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.133 0.388
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 50,983,177
Number of Sequences: 37866
Number of extensions: 2982388
Number of successful extensions: 23128
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 392
Number of HSP's successfully gapped in prelim test: 814
Number of HSP's that attempted gapping in prelim test: 13374
Number of HSP's gapped (non-prelim): 6242
length of query: 1104
length of database: 18,247,518
effective HSP length: 113
effective length of query: 991
effective length of database: 13,968,660
effective search space: 13842942060
effective search space used: 13842942060
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.