BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|119120907 par-3 partitioning defective 3 homolog B isoform a [Homo sapiens] (1104 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|119120907 par-3 partitioning defective 3 homolog B isoform a ... 2234 0.0 gi|119120897 par-3 partitioning defective 3 homolog B isoform b ... 1642 0.0 gi|119120903 par-3 partitioning defective 3 homolog B isoform c ... 1561 0.0 gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens] 538 e-152 gi|148746189 multiple PDZ domain protein [Homo sapiens] 107 5e-23 gi|112382257 InaD-like [Homo sapiens] 106 1e-22 gi|45827729 scribble isoform b [Homo sapiens] 91 6e-18 gi|45827731 scribble isoform a [Homo sapiens] 91 6e-18 gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 86 3e-16 gi|24025688 ligand of numb-protein X 2 [Homo sapiens] 85 3e-16 gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 83 1e-15 gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 83 1e-15 gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 83 1e-15 gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 83 1e-15 gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 82 2e-15 gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 82 3e-15 gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 82 3e-15 gi|148833504 interleukin 16 isoform 2 [Homo sapiens] 82 3e-15 gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 81 6e-15 gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 81 6e-15 gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 81 6e-15 gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 80 1e-14 gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens] 80 1e-14 gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens] 80 1e-14 gi|87196343 PDZ domain containing 2 [Homo sapiens] 75 4e-13 gi|218505835 membrane-associated guanylate kinase-related 3 iso... 73 2e-12 gi|27262655 interleukin 16 isoform 1 precursor [Homo sapiens] 71 5e-12 gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo sa... 71 6e-12 gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo sa... 71 6e-12 gi|155969695 membrane-associated guanylate kinase-related 3 iso... 69 2e-11 >gi|119120907 par-3 partitioning defective 3 homolog B isoform a [Homo sapiens] Length = 1104 Score = 2234 bits (5788), Expect = 0.0 Identities = 1104/1104 (100%), Positives = 1104/1104 (100%) Query: 1 MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD 60 MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD Sbjct: 1 MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD 60 Query: 61 PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG 120 PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG Sbjct: 61 PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG 120 Query: 121 EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL 180 EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL Sbjct: 121 EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL 180 Query: 181 NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS 240 NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS Sbjct: 181 NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS 240 Query: 241 RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV 300 RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV Sbjct: 241 RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV 300 Query: 301 IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG 360 IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG Sbjct: 301 IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG 360 Query: 361 KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA 420 KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA Sbjct: 361 KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA 420 Query: 421 AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKG 480 AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKG Sbjct: 421 AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKG 480 Query: 481 EPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFK 540 EPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFK Sbjct: 481 EPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFK 540 Query: 541 DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA 600 DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA Sbjct: 541 DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA 600 Query: 601 ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPT 660 ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPT Sbjct: 601 ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPT 660 Query: 661 PHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKV 720 PHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKV Sbjct: 661 PHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKV 720 Query: 721 HSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNES 780 HSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNES Sbjct: 721 HSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNES 780 Query: 781 FRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEK 840 FRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEK Sbjct: 781 FRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEK 840 Query: 841 EKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGL 900 EKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGL Sbjct: 841 EKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGL 900 Query: 901 REEELEKMKEERESGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWV 960 REEELEKMKEERESGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWV Sbjct: 901 REEELEKMKEERESGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWV 960 Query: 961 PGRGPDGNAHNLRFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHP 1020 PGRGPDGNAHNLRFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHP Sbjct: 961 PGRGPDGNAHNLRFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHP 1020 Query: 1021 PKGSYPRPTELRVADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPR 1080 PKGSYPRPTELRVADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPR Sbjct: 1021 PKGSYPRPTELRVADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPR 1080 Query: 1081 GGSPDQYPYRTQDSRQKNPMTAAV 1104 GGSPDQYPYRTQDSRQKNPMTAAV Sbjct: 1081 GGSPDQYPYRTQDSRQKNPMTAAV 1104 >gi|119120897 par-3 partitioning defective 3 homolog B isoform b [Homo sapiens] Length = 1143 Score = 1642 bits (4252), Expect = 0.0 Identities = 875/1054 (83%), Positives = 889/1054 (84%), Gaps = 108/1054 (10%) Query: 1 MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD 60 MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD Sbjct: 1 MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD 60 Query: 61 PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG 120 PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG Sbjct: 61 PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG 120 Query: 121 EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL 180 EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL Sbjct: 121 EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL 180 Query: 181 NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS 240 NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS Sbjct: 181 NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS 240 Query: 241 RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV 300 RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV Sbjct: 241 RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV 300 Query: 301 IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG 360 IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG Sbjct: 301 IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG 360 Query: 361 KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA 420 KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA Sbjct: 361 KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA 420 Query: 421 AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKG 480 AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPREL G Sbjct: 421 AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELDG 480 Query: 481 EPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFK 540 + +ND A G SL G Sbjct: 481 -----------------RLRMNDQLIAVNGESLLG------------------------- 498 Query: 541 DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA 600 KSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA Sbjct: 499 --------------------KSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA 538 Query: 601 ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPT 660 ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPT Sbjct: 539 ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPT 598 Query: 661 PHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKV 720 PHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKV Sbjct: 599 PHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKV 658 Query: 721 HSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNES 780 HSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNES Sbjct: 659 HSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNES 718 Query: 781 FRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEK 840 FRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEK Sbjct: 719 FRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEK 778 Query: 841 EKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGL 900 EKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGL Sbjct: 779 EKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGL 838 Query: 901 REEELEKMKEERESGRPTGGSTDRIQKLRKEYYQARREGFPLY-----------EDDE-- 947 REEELEKMKEERE RI +E + + G Y +DDE Sbjct: 839 REEELEKMKEERE----------RIGAKHQELREKQARGLLDYATGAIGSVYDMDDDEMD 888 Query: 948 -GRARPSEYDLLWVPGRGPDGNAHNLRFEGMERQYASLPRGGP-ADPVDYLPAAP----- 1000 AR + + R P +A+ R S PR GP P D P +P Sbjct: 889 PNYARVNHF-------REPCTSANVFR-------SPSPPRAGPFGYPRDGHPLSPERDHL 934 Query: 1001 RGLYKERELPYYP--GAHPMHPPKGSYPRPTELR 1032 GLY + PY+P A P GS R +LR Sbjct: 935 EGLYAKVNKPYHPLVPADSGRPTGGSTDRIQKLR 968 Score = 419 bits (1077), Expect = e-117 Identities = 191/192 (99%), Positives = 192/192 (100%) Query: 913 ESGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDGNAHNL 972 +SGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDGNAHNL Sbjct: 952 DSGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDGNAHNL 1011 Query: 973 RFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELR 1032 RFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELR Sbjct: 1012 RFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELR 1071 Query: 1033 VADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQ 1092 VADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQ Sbjct: 1072 VADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQ 1131 Query: 1093 DSRQKNPMTAAV 1104 DSRQKNPMTAAV Sbjct: 1132 DSRQKNPMTAAV 1143 >gi|119120903 par-3 partitioning defective 3 homolog B isoform c [Homo sapiens] Length = 1136 Score = 1561 bits (4043), Expect = 0.0 Identities = 844/1054 (80%), Positives = 867/1054 (82%), Gaps = 115/1054 (10%) Query: 1 MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD 60 MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD Sbjct: 1 MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD 60 Query: 61 PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG 120 PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG Sbjct: 61 PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG 120 Query: 121 EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL 180 EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL Sbjct: 121 EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL 180 Query: 181 NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS 240 NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS Sbjct: 181 NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS 240 Query: 241 RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV 300 RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV Sbjct: 241 RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV 300 Query: 301 IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG 360 IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG Sbjct: 301 IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG 360 Query: 361 KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA 420 KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA Sbjct: 361 KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA 420 Query: 421 AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKG 480 AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKG Sbjct: 421 AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKG 480 Query: 481 EPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFK 540 EPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFK Sbjct: 481 EPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFK 540 Query: 541 DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA 600 DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA Sbjct: 541 DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA 600 Query: 601 ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPT 660 ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPT Sbjct: 601 ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPT 660 Query: 661 PHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKV 720 PHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKV Sbjct: 661 PHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKV 720 Query: 721 HSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNES 780 HSLAGQKS+ GL SS H +G Sbjct: 721 HSLAGQKSD----------GLSDKSS-----------------------HSGQG------ 741 Query: 781 FRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEK 840 L+ +S+ G L E +++ + K +K +K K Sbjct: 742 ------------------ALNCESAPQGNSEL--EDMENKARKVKKTKEKEKKKEKGK-- 779 Query: 841 EKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGL 900 LKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGL Sbjct: 780 --------LKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGL 831 Query: 901 REEELEKMKEERESGRPTGGSTDRIQKLRKEYYQARREGFPLY-----------EDDE-- 947 REEELEKMKEERE RI +E + + G Y +DDE Sbjct: 832 REEELEKMKEERE----------RIGAKHQELREKQARGLLDYATGAIGSVYDMDDDEMD 881 Query: 948 -GRARPSEYDLLWVPGRGPDGNAHNLRFEGMERQYASLPRGGP-ADPVDYLPAAP----- 1000 AR + + R P +A+ R S PR GP P D P +P Sbjct: 882 PNYARVNHF-------REPCTSANVFR-------SPSPPRAGPFGYPRDGHPLSPERDHL 927 Query: 1001 RGLYKERELPYYP--GAHPMHPPKGSYPRPTELR 1032 GLY + PY+P A P GS R +LR Sbjct: 928 EGLYAKVNKPYHPLVPADSGRPTGGSTDRIQKLR 961 Score = 419 bits (1077), Expect = e-117 Identities = 191/192 (99%), Positives = 192/192 (100%) Query: 913 ESGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDGNAHNL 972 +SGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDGNAHNL Sbjct: 945 DSGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDGNAHNL 1004 Query: 973 RFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELR 1032 RFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELR Sbjct: 1005 RFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELR 1064 Query: 1033 VADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQ 1092 VADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQ Sbjct: 1065 VADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQ 1124 Query: 1093 DSRQKNPMTAAV 1104 DSRQKNPMTAAV Sbjct: 1125 DSRQKNPMTAAV 1136 >gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens] Length = 1356 Score = 538 bits (1385), Expect = e-152 Identities = 413/1147 (36%), Positives = 568/1147 (49%), Gaps = 239/1147 (20%) Query: 154 SASHPG-GQSLKLVVPDSTQNLEDR---EVLNGVQTELLTSPRTKDTLSDMTRTVEISGE 209 SASHP G+ L+ D ED E + T L P +L DM + VE+ + Sbjct: 223 SASHPMVGKWLEKQEQDEDGTEEDNSRVEPVGHADTGLEHIPNF--SLDDMVKLVEVPND 280 Query: 210 GGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQ 269 GGPLGIHVVPF S+ GR LGL ++ +E +++ E LF EN+CIV+IN+ DL ++ F Q Sbjct: 281 GGPLGIHVVPF-SARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQ 339 Query: 270 AQDVFRQAMKSPSVLLHVLPPQNREQYEK-SVIGSLNIFGNNDGVLKTKVPPPVHGKSGL 328 AQ +FRQAM++P + HV+P N+EQYE+ S N + + + +GL Sbjct: 340 AQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGL 399 Query: 329 KT---ANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPL--------MGFGSNK 377 T A + D+ + L + P G PS+P+ +P G+ + K Sbjct: 400 HTVQRAPRLNHPPEQIDSHSRLPHSAHPS----GKPPSAPASAPQNVFSTTVSSGYNTKK 455 Query: 378 NAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVN 437 K++ I LKKG EGLGF++ +RD +I G PI+VKNILP+GAAI+DGRL++GDR++EVN Sbjct: 456 IGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVN 515 Query: 438 GRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETS----- 492 G D+ G++QEE+V++LRSTK T SL++ RQE F PREL EP + ET Sbjct: 516 GVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDED 575 Query: 493 ---------EQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGR 543 E LTFE+PLNDSGSAGLGVS+KGN+S+E DLGIF+KSII+GGAA KDGR Sbjct: 576 IVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGR 635 Query: 544 LRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRR------------ 591 LR+NDQLIAVNGESLLGK+N +AMETLRRSMS EGN RGMIQL++ RR Sbjct: 636 LRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695 Query: 592 ---PERPMEDPAECGA--FSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLP 646 PE P+E + S + + + RN ++ +G + +P Sbjct: 696 PPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNA-ALSRIMGESGKYQLSPTVNMP 754 Query: 647 NDGWAESE------VPP------SPTPHSALGL--------------GLEDYSHSSGVDS 680 D E +PP S + H +G D S S VD Sbjct: 755 QDDTVIIEDDRLPVLPPHLSDQSSSSSHDDVGFVTADAGTWAKAAISDSADCSLSPDVDP 814 Query: 681 AVYFPDQHINFRSVTPAR--------QPESINLKASKSMDL-VPDESKVHSLAGQKSESP 731 + F + +S++ R Q + + + SKSMDL + DE+K++++ QK+ SP Sbjct: 815 VLAFQREGFGRQSMSEKRTKQFSDASQLDFVKTRKSKSMDLGIADETKLNTVDDQKAGSP 874 Query: 732 SKDFGPTLGLKKSSSLESLQTAVAEVRKN-DLPFHRPRPHMVRGRGCNESFRAAIDKSYD 790 S+D GP+LGLKKSSSLESLQTAVAEV N D+PFHRPRP ++RGRGCNESFRAAIDKSYD Sbjct: 875 SRDVGPSLGLKKSSSLESLQTAVAEVTLNGDIPFHRPRPRIIRGRGCNESFRAAIDKSYD 934 Query: 791 GP----------------EEIEADGLSDKSSHSGQGALNCESAPQGNSELEDM-ENKARK 833 P EE G S+ S Q + + E GN E D + K K Sbjct: 935 KPAVDDDDEGMETLEEDTEESSRSGRESVSTASDQPSHSLERQMNGNQEKGDKTDRKKDK 994 Query: 834 VKKTKEKEKKKEKGKLKVKE-------------KKRKEENEDPERKIK------------ 868 K K+K++ KEK K+K K+ K RK++ + KIK Sbjct: 995 TGKEKKKDRDKEKDKMKAKKGMLKGLGDMFRFGKHRKDDKIEKTGKIKIQESFTSEEERI 1054 Query: 869 -----KKGFGAMLRFGKKKEDK----------------------GGKAEQKGTL------ 895 ++ A R ++++ + GG + +G++ Sbjct: 1055 RMKQEQERIQAKTREFRERQARERDYAEIQDFHRTFGCDDELMYGGVSSYEGSMALNARP 1114 Query: 896 ---KHGGLREEELEKMKEER-------ESGRPTGGSTDRIQKLRKEYYQARREGFPLYED 945 + G + + ++K+ R +S R T + DRIQ+LR+E+ QA+++ ED Sbjct: 1115 QSPREGHMMDALYAQVKKPRNSKPSPVDSNRSTPSNHDRIQRLRQEFQQAKQD-----ED 1169 Query: 946 DEGRARPSEYDLLWVPGR-GPDGNAHNLRFEGM---------------ERQYASLPRGGP 989 E R R ++ W R H++ E +RQY+SLPR Sbjct: 1170 VEDRRRTYSFEQPWPNARPATQSGRHSVSVEVQMQRQRQEERESSQQAQRQYSSLPRQSR 1229 Query: 990 ADPV---------DYLPAAPRGLYKERELPYYP----------GAHPMHPPKGSYPRPTE 1030 + +Y P G +E P Y G H + + Sbjct: 1230 KNASSVSQDSWEQNYSPG--EGFQSAKENPRYSSYQGSRNGYLGGHGFNA-RVMLETQEL 1286 Query: 1031 LRVADLRYPQHY---PPPPAPQH---------------KGPFRQDVPPSPPQHQRMPAYQ 1072 LR R Q PP P + KGPFRQDVPPSP Q R+ Q Sbjct: 1287 LRQEQRRKEQQMKKQPPSEGPSNYDSYKKVQDPSYAPPKGPFRQDVPPSPSQVARLNRLQ 1346 Query: 1073 --ETGRP 1077 E GRP Sbjct: 1347 TPEKGRP 1353 Score = 156 bits (395), Expect = 9e-38 Identities = 78/146 (53%), Positives = 102/146 (69%), Gaps = 3/146 (2%) Query: 1 MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD 60 MKVTVCFGRT +VVPC +G ++V L QQA+ RY K K P YW+++H LE+ DGGILD Sbjct: 1 MKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWIQVHRLEHGDGGILD 60 Query: 61 PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAA-QLAAFKP-- 117 DD+L DV +DKD+L+AVF+EQ+P H + S + QSP+ F +E+ ++AF+P Sbjct: 61 LDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQ 120 Query: 118 IGGEIEVTPSALKLGTPLLVRRSSDP 143 EIEVTPS L+ PL VRRSSDP Sbjct: 121 ATSEIEVTPSVLRANMPLHVRRSSDP 146 >gi|148746189 multiple PDZ domain protein [Homo sapiens] Length = 2041 Score = 107 bits (268), Expect = 5e-23 Identities = 139/583 (23%), Positives = 239/583 (40%), Gaps = 93/583 (15%) Query: 65 LADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGGEIEV 124 L + ++D L V + H + + G A + E+ PI I + Sbjct: 1493 LGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGY----PIEKFISL 1548 Query: 125 TPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVLNGVQ 184 +A K+ L + + P+ ++ S L+VP S E + N + Sbjct: 1549 LKTA-KMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSP-EPESIRNTSR 1606 Query: 185 TE----LLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS 240 + + P T + T+EIS LG+ +V +L G I+ I + + Sbjct: 1607 SSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAII---IHEVYEEG 1663 Query: 241 RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLH--VLPPQNREQYEK 298 + ++G + I+++N +DL T +A +V RQ + + L+ P + E + Sbjct: 1664 AACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDT 1723 Query: 299 SVIG---------SLNIFG--NNDGVLKTKVPPPVHGKSGLKTAN-----------LTGT 336 I L+I G N+ GV + + K G+ A+ + G Sbjct: 1724 LTIELQKKPGKGLGLSIVGKRNDTGVFVSDIV-----KGGIADADGRLMQGDQILMVNGE 1778 Query: 337 D--SPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKI------DLKK 388 D + +A A+L + + S S S + S KNA +I ++KK Sbjct: 1779 DVRNATQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKK 1838 Query: 389 GP-EGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQE 447 GP + LG ++ S G PIF+ + P G A + +L+ GDRI+ + G G T Sbjct: 1839 GPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHT 1898 Query: 448 ELVAMLRSTK--------QGETASLVIARQE-------------GHFLPRELKGEPDCCA 486 + V +L++ G S+V Q+ + ++ G P C + Sbjct: 1899 QAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKS 1958 Query: 487 LSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRM 546 ++LE G GLG S+ G G DL I++K++ GAA +DGRL+ Sbjct: 1959 ITLER-------------GPDGLGFSIVGGYGSPHG-DLPIYVKTVFAKGAASEDGRLKR 2004 Query: 547 NDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVIL 589 DQ+IAVNG+SL G ++ EA+ L+R+ +G + L++L Sbjct: 2005 GDQIIAVNGQSLEGVTHEEAVAILKRT-------KGTVTLMVL 2040 Score = 106 bits (264), Expect = 1e-22 Identities = 98/408 (24%), Positives = 182/408 (44%), Gaps = 63/408 (15%) Query: 167 VPDSTQNLEDREVLNGVQTELLTSPRTKDTLS-DMTRTVEISGEGGPLGIHVVPFFSSLS 225 +P +++NL+++E + + TS D S + +E+ + G LGI + S Sbjct: 1450 LPSNSENLQNKET----EPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAI-----SEE 1500 Query: 226 GRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLL 285 + G+ I+ + ++ + +G + I+ +++ +V + + + A + + + Sbjct: 1501 DTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI 1560 Query: 286 HVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASA 345 H P + Q S G+ + K+ ++ + + SPE ++ Sbjct: 1561 HAENPDS--QAVPSAAGAAS----------------GEKKNSSQSLMVPQSGSPEPESIR 1602 Query: 346 SLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIH 405 + ++ +P + S P+ P++ + I++ KG GLG ++V ++ Sbjct: 1603 NTSRSSTPAI-----FASDPATCPIIP------GCETTIEISKGRTGLGLSIVGGSDTLL 1651 Query: 406 GPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLV 465 G I + + +GAA KDGRL +GD+ILEVNG D+ T +E + +LR T Q L Sbjct: 1652 GA--IIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQ--RVRLT 1707 Query: 466 IARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDL 525 + R E + K E C L++E L GLG+S+ G ++ D Sbjct: 1708 LYRDEAPY-----KEEEVCDTLTIE----------LQKKPGKGLGLSIVGKRN-----DT 1747 Query: 526 GIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 573 G+F+ I+ GG A DGRL DQ++ VNGE + + L+ S Sbjct: 1748 GVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVS 1795 Score = 92.8 bits (229), Expect = 2e-18 Identities = 86/278 (30%), Positives = 127/278 (45%), Gaps = 48/278 (17%) Query: 343 ASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKN--AKKIKIDLKKGPEGLGFTVVTR 400 A SL Q SP V R SPS + + SN I+L GLGF ++ Sbjct: 221 ARGSLPQLVSPIVSR------SPSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGG 274 Query: 401 DSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGE 460 ++ + VK ILP G A + GRL SGD IL++ D+ G + E++ +LR G Sbjct: 275 KAT-----GVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQC--GN 327 Query: 461 TASLVIARQEGHFLPRELKGEPDCCALSLETS-----------------EQLTFEIPLND 503 L+IAR E + P ++L +S E TF++ L Sbjct: 328 RVKLMIARGA-----IEERTAPTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTK 382 Query: 504 SGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSN 563 + GLG+++ G + GIF+KSI A DGR+++ DQ+IAV+G +L G +N Sbjct: 383 NVQ-GLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTN 441 Query: 564 HEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAE 601 +A+E LR + Q V+L R M+ AE Sbjct: 442 QQAVEVLRHTG----------QTVLLTLMRRGMKQEAE 469 Score = 86.7 bits (213), Expect = 1e-16 Identities = 116/436 (26%), Positives = 189/436 (43%), Gaps = 70/436 (16%) Query: 174 LEDREVLNGVQTELLTSPRTKDTLSDMTRTVEISGEGGP-LGIHVVP---FFSSLS-GRI 228 L +RE G ++EL T + + R VE+ E LGI +V S LS G + Sbjct: 1125 LPEREEGEGEESEL---QNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEV 1181 Query: 229 L-GLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLL-- 285 + G+FI+ + ++S + + G + IV+++ +DL D + QA + R+A +P V + Sbjct: 1182 MRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKA-GNPVVFMVQ 1240 Query: 286 --------HVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTD 337 LP Y K S N F ++ + K P +S + A L Sbjct: 1241 SIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPS--QSESEPEKAPLCSVP 1298 Query: 338 SPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG-SNKNAKKI---------KIDLK 387 P A A + + + + S + FG S KN ++ I+L+ Sbjct: 1299 PPPPSAFAEMGSDHT----QSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELE 1354 Query: 388 KGPEGLGFTVV-TRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQ 446 KG GLG ++ +D S +F+ I P GAA KDGRLQ D +LE+NG+ + GR+ Sbjct: 1355 KGHSGLGLSLAGNKDRSRMS---VFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSH 1411 Query: 447 EELVAMLR-----------STKQGETASLVIARQEGHFLP------RELKGEPDC----C 485 + ++++ K V LP + + EP Sbjct: 1412 QNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDA 1471 Query: 486 ALSLETSEQLT-FEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRL 544 A+ L + + + E+P D G G+ +S E T G+ IKS+ G A DGRL Sbjct: 1472 AVDLSSFKNVQHLELP-KDQGGLGIAIS-------EEDTLSGVIIKSLTEHGVAATDGRL 1523 Query: 545 RMNDQLIAVNGESLLG 560 ++ DQ++AV+ E ++G Sbjct: 1524 KVGDQILAVDDEIVVG 1539 Score = 82.8 bits (203), Expect = 2e-15 Identities = 81/308 (26%), Positives = 134/308 (43%), Gaps = 26/308 (8%) Query: 271 QDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKT 330 + V + + S + L Q ++Q + + NI + L V P + +S L + Sbjct: 37 KSVLQSPLFSQILSLQTSVQQLKDQVNIATSATSNIEYAHVPHLSPAVIPTLQNESFLLS 96 Query: 331 ANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGP 390 N + +L+ P +P + GKP+ L+ + ++ LK Sbjct: 97 PN-----------NGNLEALTGPGIPHINGKPACDEFDQLIKNMAQGRHVEVFELLKPPS 145 Query: 391 EGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGR-TQEEL 449 GLGF+VV S G IFV+ I A +DGRL+ D+IL +NG+ + T ++ Sbjct: 146 GGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQA 205 Query: 450 VAMLRSTKQGETASLVIARQE-----GHFLPRELKGEPDCCALSLETSEQLTFEIPLNDS 504 +++L+ K +T LVIAR + R A S Q I L + Sbjct: 206 ISILQKAK--DTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVND 263 Query: 505 GSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNH 564 GS GLG + G K+ G+ +K+I+ GG A + GRL D ++ + L G S+ Sbjct: 264 GS-GLGFGIIGGKA------TGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSE 316 Query: 565 EAMETLRR 572 + + LR+ Sbjct: 317 QVAQVLRQ 324 Score = 80.5 bits (197), Expect = 8e-15 Identities = 111/486 (22%), Positives = 189/486 (38%), Gaps = 85/486 (17%) Query: 186 ELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKRE 245 EL T+ T VE++ LGI + + G+F++ I +S + + Sbjct: 360 ELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHD 419 Query: 246 GLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYE----KSVI 301 G + I+ ++ +L T QA +V R +VLL ++ +++ E + V Sbjct: 420 GRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHT--GQTVLLTLMRRGMKQEAELMSREDVT 477 Query: 302 GSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTD-------SPETDASASLQQNKSPR 354 ++ N ++K S + N+ T+ S E + Q+ ++ Sbjct: 478 KDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAAL 537 Query: 355 VPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKN 414 + + +MG N + + + K E G + + H F+++ Sbjct: 538 LTKW---------QRIMGI----NYEIVVAHVSKFSENSGLGISLEATVGHH----FIRS 580 Query: 415 ILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRS----------------TKQ 458 +LP+G G+L SGD +LEVNG + G +++V +L+ T Q Sbjct: 581 VLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQ 640 Query: 459 GETASLVIARQE---------GHFLPRELKGEPDCCALSLETSEQLTFEI--PLN----- 502 E SL + E G F+ +P L++ + Q T E+ PL Sbjct: 641 SELDSLDLCDIELTEKPHVDLGEFIGSSETEDP---VLAMTDAGQSTEEVQAPLAMWEAG 697 Query: 503 ------DSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGE 556 + GS GLG S+ + I I+S++ GG A KDGRL D+L+ VN Sbjct: 698 IQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDV 757 Query: 557 SLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPER------------PMEDPAECGA 604 +L S EA+E L+ + S G +R + + PE P E G Sbjct: 758 NLENSSLEEAVEALKGAPS--GTVRIGVAKPLPLSPEEGYVSAKEDSFLYPPHSCEEAGL 815 Query: 605 FSKPCF 610 KP F Sbjct: 816 ADKPLF 821 Score = 71.6 bits (174), Expect = 4e-12 Identities = 118/503 (23%), Positives = 194/503 (38%), Gaps = 129/503 (25%) Query: 211 GPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDK-TFAQ 269 G LG VV S G LG+F++ I++ S + R+G E + I+ IN L T Q Sbjct: 146 GGLGFSVVGLRSENRGE-LGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQ 204 Query: 270 AQDVFRQA---------------------MKSPS----VLLHVLPP--QNREQYEKSVIG 302 A + ++A +SPS + H P Q+ E E G Sbjct: 205 AISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVNDG 264 Query: 303 SLNIFGNNDG-----VLKTKVPPPV---HGK--SG-----LKTANLTGTDSPETD----- 342 S FG G ++KT +P V HG+ SG + +L G S + Sbjct: 265 SGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQ 324 Query: 343 ---------ASASLQQNKSPR---VPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGP 390 A ++++ +P + S+P L + ++ ++L K Sbjct: 325 CGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTKNV 384 Query: 391 EGLGFTVV--TRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEE 448 +GLG T+ D + P IFVK+I A DGR+Q GD+I+ V+G ++ G T ++ Sbjct: 385 QGLGITIAGYIGDKKLE-PSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQ 443 Query: 449 LVAMLRSTKQGETASLVIAR---------------------------------------- 468 V +LR T G+T L + R Sbjct: 444 AVEVLRHT--GQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKENYEKDEDFL 501 Query: 469 ---QEGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLK------GNKSR 519 + + LP E +G P A E + E L +G++ + S Sbjct: 502 SSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSE 561 Query: 520 ETGTDLGI-------FIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRR 572 +G + + FI+S++ G G+L D+L+ VNG +LLG+ NH+ + + + Sbjct: 562 NSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGE-NHQDVVNILK 620 Query: 573 SMSMEGNIRGMIQLVILRRPERP 595 + +E + +V RR P Sbjct: 621 ELPIE------VTMVCCRRTVPP 637 Score = 62.8 bits (151), Expect = 2e-09 Identities = 65/259 (25%), Positives = 114/259 (44%), Gaps = 46/259 (17%) Query: 376 NKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILE 435 +K + + I++ KG LG TV + + V++I+ GA +DGR+ GD IL Sbjct: 1001 SKESFERTINIAKGNSSLGMTVSANKDGLG----MIVRSIIHGGAISRDGRIAIGDCILS 1056 Query: 436 VNGRDVTGRTQEELVAMLRS--------------TKQGETASLVIARQEGHF-------- 473 +N T + AMLR + E + + +Q G Sbjct: 1057 INEESTISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSS 1116 Query: 474 --------LPRELKGEPDCCAL--SLETSEQLTFEIPLNDSGSAGLGVSLKGNK---SRE 520 LP +GE + L + ++ + L S LG+S+ G + SR Sbjct: 1117 YTGRDIPELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRL 1176 Query: 521 TGTDL--GIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEG 578 + ++ GIFIK ++ A K+G L+ D+++ V+G L S+ +A+E +R++ G Sbjct: 1177 SNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKA----G 1232 Query: 579 N-IRGMIQLVILRRPERPM 596 N + M+Q +I R + P+ Sbjct: 1233 NPVVFMVQSIINRPRKSPL 1251 Score = 62.4 bits (150), Expect = 2e-09 Identities = 66/260 (25%), Positives = 117/260 (45%), Gaps = 44/260 (16%) Query: 202 RTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVD 261 RT+ I+ LG+ V S + LG+ +R I R+G +CI+ IN Sbjct: 1007 RTINIAKGNSSLGMTV-----SANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEES 1061 Query: 262 LVDKTFAQAQDVFRQ-AMKSPSVLLHVLPPQNREQYEKSV------IGSLNIFGNNDGVL 314 + T AQA+ + R+ ++ P + + +P ++ E+++ S+ + +L+IF + G Sbjct: 1062 TISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRD 1121 Query: 315 KTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG 374 ++P G+ + E +A N+ PR L +PS Sbjct: 1122 IPELPEREEGEG----------EESELQNTAYSNWNQ-PRRVELWREPS----------- 1159 Query: 375 SNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRIL 434 K + I + G G+G +R S+ IF+K++L A K+G L+ GDRI+ Sbjct: 1160 -----KSLGISI-VGGRGMG----SRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIV 1209 Query: 435 EVNGRDVTGRTQEELVAMLR 454 EV+G D+ + E+ V +R Sbjct: 1210 EVDGMDLRDASHEQAVEAIR 1229 Score = 57.8 bits (138), Expect = 6e-08 Identities = 29/69 (42%), Positives = 44/69 (63%), Gaps = 3/69 (4%) Query: 503 DSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKS 562 + G +GLG+SL GNK R + +FI I GAA KDGRL++ D+L+ +NG+ L G+S Sbjct: 1354 EKGHSGLGLSLAGNKDRSR---MSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRS 1410 Query: 563 NHEAMETLR 571 + A ++ Sbjct: 1411 HQNASSIIK 1419 Score = 56.2 bits (134), Expect = 2e-07 Identities = 32/85 (37%), Positives = 51/85 (60%), Gaps = 7/85 (8%) Query: 506 SAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHE 565 S GLG S+ G +S G +LGIF++ I G A +DGRL+ DQ++A+NG++L H+ Sbjct: 145 SGGLGFSVVGLRSENRG-ELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQ 203 Query: 566 AMETLRRSMSMEGNIRGMIQLVILR 590 +++S+ + +QLVI R Sbjct: 204 ------QAISILQKAKDTVQLVIAR 222 Score = 56.2 bits (134), Expect = 2e-07 Identities = 30/85 (35%), Positives = 53/85 (62%), Gaps = 6/85 (7%) Query: 489 LETSEQLTFEIPLNDS-GSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMN 547 L+ + +FE +N + G++ LG+++ NK LG+ ++SIIHGGA +DGR+ + Sbjct: 997 LQNVSKESFERTINIAKGNSSLGMTVSANKD-----GLGMIVRSIIHGGAISRDGRIAIG 1051 Query: 548 DQLIAVNGESLLGKSNHEAMETLRR 572 D ++++N ES + +N +A LRR Sbjct: 1052 DCILSINEESTISVTNAQARAMLRR 1076 >gi|112382257 InaD-like [Homo sapiens] Length = 1801 Score = 106 bits (265), Expect = 1e-22 Identities = 106/412 (25%), Positives = 180/412 (43%), Gaps = 95/412 (23%) Query: 211 GPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQA 270 G LG VV S G++ +F++ ++ S + R+ EN+ I+ IN+ L D+ + Sbjct: 143 GGLGFSVVALRSQNLGKV-DIFVKDVQPGSVADRDQRLKENDQILAINHTPL-DQNISHQ 200 Query: 271 QDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKT 330 Q + LL + GSL + + PVH KS + Sbjct: 201 QAI---------ALL------------QQTTGSLRLIVARE---------PVHTKSST-S 229 Query: 331 ANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGP 390 ++L T PET +++ ++L Sbjct: 230 SSLNDTTLPETVCWGHVEE----------------------------------VELINDG 255 Query: 391 EGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELV 450 GLGF +V +S + V+ I+P G A +DGRLQ+GD IL++ G +V G T E++ Sbjct: 256 SGLGFGIVGGKTS-----GVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVA 310 Query: 451 AMLRSTKQGETASLVIARQEGHFL------PRELKGEPDCCALSLETSEQLTFE---IPL 501 +LR+ G + +++AR + P L A S+ FE + L Sbjct: 311 QVLRNC--GNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSSLFETYNVEL 368 Query: 502 NDSGSAGLGVSLKGNK-SRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLG 560 LG+ + G + TG GI++KSII G AA+ +G +++ND+++AV+G ++ G Sbjct: 369 VRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQG 428 Query: 561 KSNHEAMETLRRSMSMEGNIRGMIQLVILRR----PERPMEDPAECGAFSKP 608 +NH+ +E LR N ++ L ++RR P+E P++ G +P Sbjct: 429 FANHDVVEVLR-------NAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEP 473 Score = 103 bits (256), Expect = 1e-21 Identities = 107/454 (23%), Positives = 189/454 (41%), Gaps = 73/454 (16%) Query: 164 KLVVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMT---RTVEISGEGGPLGIHVVPF 220 K + DS +N E+ + T + + +D+ +E+ + LG+ + Sbjct: 1206 KALTDDSDENEEE---------DAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLA-- 1254 Query: 221 FSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKS 280 + + +F+ GI + +G + +++INN L ++ A + + A Sbjct: 1255 -GNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSK 1313 Query: 281 PSVL----------LHVLP---PQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSG 327 ++ + V P P + + G+ I DG ++ + +S Sbjct: 1314 VKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESESF 1373 Query: 328 LKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNA-------- 379 + T S S Q+ P P + + GF + + Sbjct: 1374 KLAVSQMKQQKYPTKVSFSSQE--IPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIV 1431 Query: 380 --KKIKIDLKKGPEGLGFTVVT-RDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEV 436 +++ I++ KG GLG ++V +D+ ++ I + + +GAA +DGRL +GD+ILEV Sbjct: 1432 PGQEMIIEISKGRSGLGLSIVGGKDTPLNA---IVIHEVYEEGAAARDGRLWAGDQILEV 1488 Query: 437 NGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLT 496 NG D+ + EE + LR T Q LV+ R E H+ E +LE Sbjct: 1489 NGVDLRNSSHEEAITALRQTPQ--KVRLVVYRDEAHYRDEE----------NLE-----I 1531 Query: 497 FEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGE 556 F + L GLG+S+ G ++ G+FI I+ GGAA DGRL DQ+++VNGE Sbjct: 1532 FPVDLQKKAGRGLGLSIVGKRNGS-----GVFISDIVKGGAADLDGRLIQGDQILSVNGE 1586 Query: 557 SLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILR 590 + S L+ + +G++QL I R Sbjct: 1587 DMRNASQETVATILKCA-------QGLVQLEIGR 1613 Score = 77.8 bits (190), Expect = 5e-14 Identities = 69/271 (25%), Positives = 124/271 (45%), Gaps = 36/271 (13%) Query: 333 LTGTDSPETDASASLQQNKS------PRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDL 386 L TD T+ + N S P P+LG + + S + + + I I+ Sbjct: 83 LVFTDGSITNGNVHRPSNNSTVSGLFPWTPKLGNEDFN---SVIQQMAQGRQIEYIDIE- 138 Query: 387 KKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGR-T 445 + GLGF+VV S G IFVK++ P A +D RL+ D+IL +N + + Sbjct: 139 RPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNIS 198 Query: 446 QEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTF----EIPL 501 ++ +A+L+ T + L++AR+ P K E + + E+ L Sbjct: 199 HQQAIALLQQTT--GSLRLIVARE-----PVHTKSSTSSSLNDTTLPETVCWGHVEEVEL 251 Query: 502 NDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGK 561 + GS GLG + G K+ G+ +++I+ GG A +DGRL+ D ++ + G ++ G Sbjct: 252 INDGS-GLGFGIVGGKTS------GVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGM 304 Query: 562 SNHEAMETLRRSMSMEGNIRGMIQLVILRRP 592 ++ + + LR N +++++ R P Sbjct: 305 TSEQVAQVLR-------NCGNSVRMLVARDP 328 Score = 74.3 bits (181), Expect = 6e-13 Identities = 68/235 (28%), Positives = 108/235 (45%), Gaps = 41/235 (17%) Query: 373 FGSNKNAKKIKIDL-KKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGD 431 + +N + +DL KK GLG ++V + + G G +F+ +I+ GAA DGRL GD Sbjct: 1523 YRDEENLEIFPVDLQKKAGRGLGLSIVGKRN---GSG-VFISDIVKGGAADLDGRLIQGD 1578 Query: 432 RILEVNGRDVTGRTQEELVAML----------------------RSTKQGETASLVIARQ 469 +IL VNG D+ +QE + +L R+T Q S A Sbjct: 1579 QILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHS 1638 Query: 470 EGH--FLP-----RELKGEPDCCALSLETS----EQLTFEIPLNDSGSAGLGVSLKGNKS 518 H F P + L G S + S E T EI N S LG+S+ G + Sbjct: 1639 SCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEI--NRELSDALGISIAGGRG 1696 Query: 519 RETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 573 G D+ +FI I G A + +L++ D+++++NG+ L G S+ + + L+ + Sbjct: 1697 SPLG-DIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNA 1750 Score = 58.5 bits (140), Expect = 3e-08 Identities = 60/249 (24%), Positives = 102/249 (40%), Gaps = 60/249 (24%) Query: 394 GFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAML 453 G TV+ R + IF+K +L A K L++GD+ILEV+G D+ + E V + Sbjct: 1086 GQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAI 1145 Query: 454 RST------------------------------KQGETASLVIARQEGHFLPRELKGEPD 483 ++ Q + +++G P +K P Sbjct: 1146 KNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGT-APPPMKLPPP 1204 Query: 484 CCALSLETSE-------------QLTFEIPLN------DSGSAGLGVSLKGNKSRETGTD 524 AL+ ++ E Q ++P + GLG+SL GNK R Sbjct: 1205 YKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSR--- 1261 Query: 525 LGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMI 584 + IF+ I G A DGR+R+ D+L+ +N + L G+S+ A ++ + S + Sbjct: 1262 MSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPS-------KV 1314 Query: 585 QLVILRRPE 593 +LV +R + Sbjct: 1315 KLVFIRNED 1323 Score = 55.8 bits (133), Expect = 2e-07 Identities = 92/428 (21%), Positives = 166/428 (38%), Gaps = 70/428 (16%) Query: 191 PRTKDTLSDMTRTVEISGEGGPLGIHVVPFF-SSLSGRILGLFIRGIEDNSRSKREGLFH 249 P + +L + + +G LGI +V + +S +G G++++ I S + G Sbjct: 354 PGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQ 413 Query: 250 ENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGN 309 N+ IV ++ V++ + FA V + +++ ++H+ + + S + + G Sbjct: 414 VNDKIVAVDGVNI--QGFANHDVV--EVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGT 469 Query: 310 NDGVLKTKVPPPVHGKSGLKT-ANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLS 368 V++ PP + ++T N+ G D + +L+ + + +L P SP Sbjct: 470 ---VVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSP--- 523 Query: 369 PLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPI------------------ 410 +N K + + GP+ V T D+ I + Sbjct: 524 --------ENELKSRWENLLGPD-YEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEV 574 Query: 411 -------FVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETAS 463 ++ +I+ G G LQ D +LEVNG + G+++ E V+ L+ T Sbjct: 575 DSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFT-- 632 Query: 464 LVIARQEGHFLPRELKGEPDCCALSL---ETSEQLTFEIPLNDSGS-------------- 506 LV R+ F EP SL E + +D G Sbjct: 633 LVCCRR--LFDDEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELV 690 Query: 507 ---AGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSN 563 GLG S+ + T I I+S++ G A + G L D+L++VN L S Sbjct: 691 KDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSL 750 Query: 564 HEAMETLR 571 EA+E L+ Sbjct: 751 AEAVEILK 758 Score = 55.8 bits (133), Expect = 2e-07 Identities = 74/319 (23%), Positives = 136/319 (42%), Gaps = 58/319 (18%) Query: 171 TQNLEDREVLNGVQTELLTS---PRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGR 227 T L +RE G +T + PR + + ++ IS GG I + L G Sbjct: 1043 TCELPEREEGEGEETPNFSHWGPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKG- 1101 Query: 228 ILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHV 287 +FI+ + ++S + + + I++++ VDL + + ++A + + A +P V Sbjct: 1102 ---IFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNA-GNPVVF--- 1154 Query: 288 LPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASL 347 ++ SL+ +V P VH K+ +TG + +T Sbjct: 1155 ------------IVQSLSS--------TPRVIPNVHNKAN----KITGNQNQDTQEKKEK 1190 Query: 348 QQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNA---KKIK------------IDLKKGPEG 392 +Q +P P + P +L+ ++A +KI+ I+L+K G Sbjct: 1191 RQGTAP--PPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNG 1248 Query: 393 LGFTVV-TRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVA 451 LG ++ +D S IFV I P+G A DGR++ GD +LE+N + + GR+ + A Sbjct: 1249 LGLSLAGNKDRSRMS---IFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASA 1305 Query: 452 MLRSTKQGETASLVIARQE 470 ++++ LV R E Sbjct: 1306 IIKTAP--SKVKLVFIRNE 1322 Score = 40.0 bits (92), Expect = 0.012 Identities = 23/73 (31%), Positives = 40/73 (54%), Gaps = 5/73 (6%) Query: 506 SAGLGVSLKGN----KSRETGTDL-GIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLG 560 + LG+S+ G K + G +L GIFIK ++ A K L+ D+++ V+G L Sbjct: 1076 NVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQN 1135 Query: 561 KSNHEAMETLRRS 573 S+ EA+E ++ + Sbjct: 1136 ASHSEAVEAIKNA 1148 >gi|45827729 scribble isoform b [Homo sapiens] Length = 1630 Score = 90.9 bits (224), Expect = 6e-18 Identities = 114/438 (26%), Positives = 180/438 (41%), Gaps = 102/438 (23%) Query: 147 PPADTQPSASHPGGQSLKLVVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMTRTVEI 206 P D P GG L L+ P+S L R V ++E R + Sbjct: 830 PEDDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSE---------------RGLGF 874 Query: 207 SGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKT 266 S GG P+ + +G +F+ I + + R G + ++ IN VD+ + Sbjct: 875 SIAGGKGS---TPYRAGDAG----IFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEAR 927 Query: 267 FAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKS 326 A + A + ++LL E+ G L PP Sbjct: 928 HDHAVSLLTAASPTIALLL-----------EREAGGPL---------------PP----- 956 Query: 327 GLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKN---AKKIK 383 + L + P + + +P VP L PSL+P + + + ++I+ Sbjct: 957 ----SPLPHSSPPTAAVATTSITTATPGVPGL------PSLAPSLLAAALEGPYPVEEIR 1006 Query: 384 IDLKKGPEGLGFTVVTRDSS----IHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGR 439 + GP GL + SS + PG +F+ +LP+G A + G L+ GDRIL VNG+ Sbjct: 1007 LPRAGGPLGLSIVGGSDHSSHPFGVQEPG-VFISKVLPRGLAARSG-LRVGDRILAVNGQ 1064 Query: 440 DVTGRTQEELV-AMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFE 498 DV T +E V A+LR + SL++ R P L+ E Sbjct: 1065 DVRDATHQEAVSALLRPCLE---LSLLVRRDPA---PPGLR------------------E 1100 Query: 499 IPLNDSGSAGLGVSLKGNKSRETG-----TDLGIFIKSIIHGGAAFKDGRLRMNDQLIAV 553 + + + LG+S++G G TD GIFI + GAA +DGRLR+ +L+ V Sbjct: 1101 LCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEV 1160 Query: 554 NGESLLGKSNHEAMETLR 571 N +SLLG ++ EA++ LR Sbjct: 1161 NQQSLLGLTHGEAVQLLR 1178 Score = 57.0 bits (136), Expect = 1e-07 Identities = 52/212 (24%), Positives = 89/212 (41%), Gaps = 22/212 (10%) Query: 380 KKIKIDLKKGPEGLGFTVVTRDSSIHGPGP---IFVKNILPKGAAIKDGRLQSGDRILEV 436 +++ + + + GLG ++ S G IF+ + +G A + G ++ GD++LEV Sbjct: 725 EELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEV 783 Query: 437 NGRDVTGRTQEELVAMLRST--------------KQGETASLVIARQEGHFLPRELKGEP 482 NG + G E V LR + ++ R E + PRE +G Sbjct: 784 NGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGG 843 Query: 483 DCCALSLETSEQLTFE--IPLNDSGSAGLGVSLKGNKSRET--GTDLGIFIKSIIHGGAA 538 L S + + GLG S+ G K D GIF+ I GGAA Sbjct: 844 LRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAA 903 Query: 539 FKDGRLRMNDQLIAVNGESLLGKSNHEAMETL 570 + G L++ D+++++NG + + A+ L Sbjct: 904 HRAGTLQVGDRVLSINGVDVTEARHDHAVSLL 935 Score = 53.1 bits (126), Expect = 1e-06 Identities = 44/130 (33%), Positives = 62/130 (47%), Gaps = 11/130 (8%) Query: 444 RTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLND 503 R +EE + K+G S + L EP + E+LT I L Sbjct: 681 RAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEP-----ARIEEEELTLTI-LRQ 734 Query: 504 SGSAGLGVSLKGNKSRET--GTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGK 561 +G GLG+S+ G K G D GIFI + G A + G +R+ D+L+ VNG +L G Sbjct: 735 TG--GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGA 791 Query: 562 SNHEAMETLR 571 +HEA+E LR Sbjct: 792 EHHEAVEALR 801 Score = 48.1 bits (113), Expect = 4e-05 Identities = 25/57 (43%), Positives = 38/57 (66%), Gaps = 2/57 (3%) Query: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVI 466 IF+ + P GAA +DGRL+ G R+LEVN + + G T E V +LRS G+T ++++ Sbjct: 1134 IFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSV--GDTLTVLV 1188 >gi|45827731 scribble isoform a [Homo sapiens] Length = 1655 Score = 90.9 bits (224), Expect = 6e-18 Identities = 114/438 (26%), Positives = 180/438 (41%), Gaps = 102/438 (23%) Query: 147 PPADTQPSASHPGGQSLKLVVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMTRTVEI 206 P D P GG L L+ P+S L R V ++E R + Sbjct: 830 PEDDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSE---------------RGLGF 874 Query: 207 SGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKT 266 S GG P+ + +G +F+ I + + R G + ++ IN VD+ + Sbjct: 875 SIAGGKGS---TPYRAGDAG----IFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEAR 927 Query: 267 FAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKS 326 A + A + ++LL E+ G L PP Sbjct: 928 HDHAVSLLTAASPTIALLL-----------EREAGGPL---------------PP----- 956 Query: 327 GLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKN---AKKIK 383 + L + P + + +P VP L PSL+P + + + ++I+ Sbjct: 957 ----SPLPHSSPPTAAVATTSITTATPGVPGL------PSLAPSLLAAALEGPYPVEEIR 1006 Query: 384 IDLKKGPEGLGFTVVTRDSS----IHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGR 439 + GP GL + SS + PG +F+ +LP+G A + G L+ GDRIL VNG+ Sbjct: 1007 LPRAGGPLGLSIVGGSDHSSHPFGVQEPG-VFISKVLPRGLAARSG-LRVGDRILAVNGQ 1064 Query: 440 DVTGRTQEELV-AMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFE 498 DV T +E V A+LR + SL++ R P L+ E Sbjct: 1065 DVRDATHQEAVSALLRPCLE---LSLLVRRDPA---PPGLR------------------E 1100 Query: 499 IPLNDSGSAGLGVSLKGNKSRETG-----TDLGIFIKSIIHGGAAFKDGRLRMNDQLIAV 553 + + + LG+S++G G TD GIFI + GAA +DGRLR+ +L+ V Sbjct: 1101 LCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEV 1160 Query: 554 NGESLLGKSNHEAMETLR 571 N +SLLG ++ EA++ LR Sbjct: 1161 NQQSLLGLTHGEAVQLLR 1178 Score = 57.0 bits (136), Expect = 1e-07 Identities = 52/212 (24%), Positives = 89/212 (41%), Gaps = 22/212 (10%) Query: 380 KKIKIDLKKGPEGLGFTVVTRDSSIHGPGP---IFVKNILPKGAAIKDGRLQSGDRILEV 436 +++ + + + GLG ++ S G IF+ + +G A + G ++ GD++LEV Sbjct: 725 EELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEV 783 Query: 437 NGRDVTGRTQEELVAMLRST--------------KQGETASLVIARQEGHFLPRELKGEP 482 NG + G E V LR + ++ R E + PRE +G Sbjct: 784 NGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGG 843 Query: 483 DCCALSLETSEQLTFE--IPLNDSGSAGLGVSLKGNKSRET--GTDLGIFIKSIIHGGAA 538 L S + + GLG S+ G K D GIF+ I GGAA Sbjct: 844 LRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAA 903 Query: 539 FKDGRLRMNDQLIAVNGESLLGKSNHEAMETL 570 + G L++ D+++++NG + + A+ L Sbjct: 904 HRAGTLQVGDRVLSINGVDVTEARHDHAVSLL 935 Score = 53.1 bits (126), Expect = 1e-06 Identities = 44/130 (33%), Positives = 62/130 (47%), Gaps = 11/130 (8%) Query: 444 RTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLND 503 R +EE + K+G S + L EP + E+LT I L Sbjct: 681 RAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEP-----ARIEEEELTLTI-LRQ 734 Query: 504 SGSAGLGVSLKGNKSRET--GTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGK 561 +G GLG+S+ G K G D GIFI + G A + G +R+ D+L+ VNG +L G Sbjct: 735 TG--GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGA 791 Query: 562 SNHEAMETLR 571 +HEA+E LR Sbjct: 792 EHHEAVEALR 801 Score = 48.1 bits (113), Expect = 4e-05 Identities = 25/57 (43%), Positives = 38/57 (66%), Gaps = 2/57 (3%) Query: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVI 466 IF+ + P GAA +DGRL+ G R+LEVN + + G T E V +LRS G+T ++++ Sbjct: 1134 IFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSV--GDTLTVLV 1188 >gi|119943106 synapse-associated protein 102 isoform a [Homo sapiens] Length = 817 Score = 85.5 bits (210), Expect = 3e-16 Identities = 85/298 (28%), Positives = 128/298 (42%), Gaps = 50/298 (16%) Query: 374 GSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGD 431 GS+ K +I L++G GLGF++ + H P IF+ I+P GAA DGRL D Sbjct: 122 GSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVND 181 Query: 432 RILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLET 491 +L VN DV+ V L+ G LV+ R++ Sbjct: 182 CVLRVNEVDVSEVVHSRAVEALKEA--GPVVRLVVRRRQ--------------------P 219 Query: 492 SEQLTFEIPLNDSGSAGLGVSLKGN-KSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQL 550 + E+ L G GLG S+ G ++ D I+I II GGAA KDGRL++ D+L Sbjct: 220 PPETIMEVNLL-KGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRL 278 Query: 551 IAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKPCF 610 +AVN +L + EA+ +L+ N M+ L + + + D ++ P + Sbjct: 279 LAVNNTNLQDVRHEEAVASLK-------NTSDMVYLKVAKPGSLHLND-----MYAPPDY 326 Query: 611 ENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPP---SPTPHSAL 665 + A+ + + NS L LG + A +VPP SP P L Sbjct: 327 ASTFTALADNHISHNSSLGYLGAVESKVSYP---------APPQVPPTRYSPIPRHML 375 Score = 82.4 bits (202), Expect = 2e-15 Identities = 67/239 (28%), Positives = 108/239 (45%), Gaps = 55/239 (23%) Query: 382 IKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGDRILEVNGR 439 ++++L KGP+GLGF++ + H PG I++ I+ GAA KDGRLQ GDR+L VN Sbjct: 225 MEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNT 284 Query: 440 DVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCC-------------- 485 ++ EE VA L++T + L +A+ G ++ PD Sbjct: 285 NLQDVRHEEAVASLKNTS--DMVYLKVAKP-GSLHLNDMYAPPDYASTFTALADNHISHN 341 Query: 486 -------ALSLETSEQLTFEIP------------------------LNDSGSAGLGVSLK 514 A+ + S ++P + GS GLG ++ Sbjct: 342 SSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIV 401 Query: 515 GNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 573 G + E GIF+ I+ GG A G LR D++++VNG +L ++ +A L+R+ Sbjct: 402 GGEDGE-----GIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRA 455 Score = 52.0 bits (123), Expect = 3e-06 Identities = 35/79 (44%), Positives = 42/79 (53%), Gaps = 4/79 (5%) Query: 383 KIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVT 442 KI L KG GLGF +V + G G IFV IL G A G L+ GDRIL VNG ++ Sbjct: 386 KIILHKGSTGLGFNIVGGED---GEG-IFVSFILAGGPADLSGELRRGDRILSVNGVNLR 441 Query: 443 GRTQEELVAMLRSTKQGET 461 T E+ A L+ Q T Sbjct: 442 NATHEQAAAALKRAGQSVT 460 Score = 31.6 bits (70), Expect = 4.3 Identities = 21/84 (25%), Positives = 39/84 (46%), Gaps = 6/84 (7%) Query: 230 GLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLP 289 G+FI I + +G N+C++++N VD+ + ++A + ++A P V L V Sbjct: 159 GIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEA--GPVVRLVV-- 214 Query: 290 PQNREQYEKSVIGSLNIFGNNDGV 313 R Q I +N+ G+ Sbjct: 215 --RRRQPPPETIMEVNLLKGPKGL 236 >gi|24025688 ligand of numb-protein X 2 [Homo sapiens] Length = 690 Score = 85.1 bits (209), Expect = 3e-16 Identities = 67/205 (32%), Positives = 97/205 (47%), Gaps = 18/205 (8%) Query: 384 IDLKKGP-EGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVT 442 I +KK P E LG TV S G PIFV ++ P G +DGR++ GD +L +NG D+T Sbjct: 469 ITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLT 528 Query: 443 GRTQEELVAMLRSTKQGETASLVI--------ARQEGHFLPREL-KGEPDCCA------- 486 + E VAML+++ +L A Q P + E D Sbjct: 529 NLSHSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMW 588 Query: 487 LSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRM 546 L L ++ +I L S G S+ G E T+ FIK+I+ G A+ DGRL+ Sbjct: 589 LGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYE-ENHTNQPFFIKTIVLGTPAYYDGRLKC 647 Query: 547 NDQLIAVNGESLLGKSNHEAMETLR 571 D ++AVNG S +G S+ + L+ Sbjct: 648 GDMIVAVNGLSTVGMSHSALVPMLK 672 Score = 70.9 bits (172), Expect = 6e-12 Identities = 58/211 (27%), Positives = 96/211 (45%), Gaps = 25/211 (11%) Query: 381 KIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440 ++ + + E LG +V R PG +F+ ++L G A +DGRL S DR+L +NG D Sbjct: 339 QVALHKRDSGEQLGIKLVRRTDE---PG-VFILDLLEGGLAAQDGRLSSNDRVLAINGHD 394 Query: 441 VTGRTQEELVAMLRSTKQGETASLVIAR----QEG--------------HFLPRELKGEP 482 + T E +++++ GE +L IAR Q G H P P Sbjct: 395 LKYGTPELAAQIIQAS--GERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRP 452 Query: 483 DCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDG 542 + I + LG+++ G + ++G +L IF+ S+ G +DG Sbjct: 453 SSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSKSG-ELPIFVTSVPPHGCLARDG 511 Query: 543 RLRMNDQLIAVNGESLLGKSNHEAMETLRRS 573 R++ D L+ +NG L S+ EA+ L+ S Sbjct: 512 RIKRGDVLLNINGIDLTNLSHSEAVAMLKAS 542 Score = 56.6 bits (135), Expect = 1e-07 Identities = 46/151 (30%), Positives = 78/151 (51%), Gaps = 17/151 (11%) Query: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469 I ++ + G +DGRL +GD+IL+VN +++ + A+L ++ T L + R+ Sbjct: 260 IVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVL--SQPCNTLHLTVLRE 317 Query: 470 EGHFLPRELKGEPDCCALSLETSEQLTFEIPLN--DSGSAGLGVSLKGNKSRETGTDLGI 527 R + S E++ F++ L+ DSG LG+ L R T + G+ Sbjct: 318 ------RRFGNRAHNHSDSNSPREEI-FQVALHKRDSGEQ-LGIKLV----RRTD-EPGV 364 Query: 528 FIKSIIHGGAAFKDGRLRMNDQLIAVNGESL 558 FI ++ GG A +DGRL ND+++A+NG L Sbjct: 365 FILDLLEGGLAAQDGRLSSNDRVLAINGHDL 395 Score = 55.5 bits (132), Expect = 3e-07 Identities = 58/253 (22%), Positives = 97/253 (38%), Gaps = 48/253 (18%) Query: 213 LGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQD 272 LG+ V S SG L +F+ + + R+G + ++ IN +DL + + ++A Sbjct: 479 LGMTVAGGRGSKSGE-LPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVA 537 Query: 273 VFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTAN 332 + + + SP+V L L Q E+ ++ + F N Sbjct: 538 MLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSEN---------------------- 575 Query: 333 LTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEG 392 E DAS S PS +G S ++ + + Sbjct: 576 -------EYDASWS------------------PSWVMWLGLPSTLHSCHDIVLRRSYLGS 610 Query: 393 LGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAM 452 GF++V H P F+K I+ A DGRL+ GD I+ VNG G + LV M Sbjct: 611 WGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPM 670 Query: 453 LRSTKQGETASLV 465 L+ + T +++ Sbjct: 671 LKEQRNKVTLTVI 683 Score = 33.9 bits (76), Expect = 0.87 Identities = 25/84 (29%), Positives = 39/84 (46%), Gaps = 4/84 (4%) Query: 487 LSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRM 546 LSL E T EI ++ LG+S+ G + I I+ + G +DGRL Sbjct: 224 LSLPEGEITTIEIHRSNP-YIQLGISIVGGNETPL---INIVIQEVYRDGVIARDGRLLA 279 Query: 547 NDQLIAVNGESLLGKSNHEAMETL 570 DQ++ VN ++ S++ A L Sbjct: 280 GDQILQVNNYNISNVSHNYARAVL 303 >gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] Length = 926 Score = 83.2 bits (204), Expect = 1e-15 Identities = 102/404 (25%), Positives = 164/404 (40%), Gaps = 72/404 (17%) Query: 380 KKIKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGDRILEVN 437 K ++I L KGP+GLGF++ + H PG I+V I+ GAA KDG+LQ GD++L VN Sbjct: 316 KIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVN 375 Query: 438 GRDVTGRTQEELVAMLRSTKQGETASLVIARQ----------------------EGHFLP 475 + T EE V L++T + L +A+ + H P Sbjct: 376 NVCLEEVTHEEAVTALKNTS--DFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSP 433 Query: 476 RELKGEPDCC-------ALSLETSEQLTFE---IPLNDSGSAGLGVSLKGNKSRETGTDL 525 G+ + ++ +++T E + L+ GS GLG ++ G + E Sbjct: 434 SSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLH-RGSTGLGFNIVGGEDGE----- 487 Query: 526 GIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQ 585 GIFI I+ GG A G LR D++I+VN L S+ +A L+ N + Sbjct: 488 GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALK-------NAGQAVT 540 Query: 586 LVILRRPERPMEDPAECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLL 645 +V RPE A+ E N+ +S G+ S + QK L Sbjct: 541 IVAQYRPEEYSRFEAKIHDLR----EQMMNSSISS-----------GSGSLRTSQKRSLY 585 Query: 646 PNDGWAESEVPPSPTPHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINL 705 + + S P L D H D+ R VTP + + + + Sbjct: 586 VRALFDYDKTKDSGLPSQGLNFKFGDILHVINASD-----DEWWQARQVTPDGESDEVGV 640 Query: 706 KASKSMDLVPDESKVHSLAGQKSESPSKDFGPTLGLKKSSSLES 749 SK + +++ ++ K S ++D G + K+ +L S Sbjct: 641 IPSKRRVEKKERARLKTV---KFNSKTRDKGQSFNDKRKKNLFS 681 Score = 82.4 bits (202), Expect = 2e-15 Identities = 71/228 (31%), Positives = 111/228 (48%), Gaps = 30/228 (13%) Query: 353 PRVPRLGGKP---SSPSL-SPLMGFGSNKNAKKIKIDLKKGPEGLGFTVV--TRDSSIHG 406 P +P+ P ++ SL +P G++ + + +I L++G GLGF++ T + I Sbjct: 190 PTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGD 249 Query: 407 PGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVI 466 IF+ I+ GAA +DGRL+ D IL VN DV T + V L+ G L + Sbjct: 250 DSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEA--GSIVRLYV 307 Query: 467 ARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRE-TGTDL 525 R++ SE++ EI L G GLG S+ G + D Sbjct: 308 KRRK-------------------PVSEKI-MEIKLI-KGPKGLGFSIAGGVGNQHIPGDN 346 Query: 526 GIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 573 I++ II GGAA KDG+L++ D+L+AVN L ++ EA+ L+ + Sbjct: 347 SIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNT 394 Score = 55.1 bits (131), Expect = 4e-07 Identities = 33/85 (38%), Positives = 50/85 (58%), Gaps = 6/85 (7%) Query: 493 EQLTFEIPLNDSGSAGLGVSLKGNKSR-ETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLI 551 E++T E G++GLG S+ G G D IFI II GGAA +DGRLR+ND ++ Sbjct: 223 EEITLE-----RGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCIL 277 Query: 552 AVNGESLLGKSNHEAMETLRRSMSM 576 VN + ++ +A+E L+ + S+ Sbjct: 278 RVNEVDVRDVTHSKAVEALKEAGSI 302 Score = 52.4 bits (124), Expect = 2e-06 Identities = 46/152 (30%), Positives = 70/152 (46%), Gaps = 15/152 (9%) Query: 314 LKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPS-LSPLMG 372 LK P ++ G ++T + S D S LG P+SP+ SP+ Sbjct: 400 LKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSF-------LGQTPASPARYSPVSK 452 Query: 373 --FGSNKNAKKI-KIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQS 429 G ++ ++ K+ L +G GLGF +V + G G IF+ IL G A G L+ Sbjct: 453 AVLGDDEITREPRKVVLHRGSTGLGFNIVGGED---GEG-IFISFILAGGPADLSGELRK 508 Query: 430 GDRILEVNGRDVTGRTQEELVAMLRSTKQGET 461 GDRI+ VN D+ + E+ A L++ Q T Sbjct: 509 GDRIISVNSVDLRAASHEQAAAALKNAGQAVT 540 Score = 33.9 bits (76), Expect = 0.87 Identities = 14/47 (29%), Positives = 28/47 (59%) Query: 231 LFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQA 277 +FI I + ++G N+CI+++N VD+ D T ++A + ++A Sbjct: 253 IFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEA 299 >gi|18375648 protein tyrosine phosphatase, non-receptor type 13 isoform 3 [Homo sapiens] Length = 2294 Score = 83.2 bits (204), Expect = 1e-15 Identities = 72/280 (25%), Positives = 121/280 (43%), Gaps = 30/280 (10%) Query: 315 KTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG 374 KTK P G S + + G + +S Q +++P+ +S ++ F Sbjct: 1112 KTKKP----GISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMN-FKTFS 1166 Query: 375 SN--KNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDR 432 S+ K +++L K LG +V ++ G I+VK ++P+GAA DGR+ GDR Sbjct: 1167 SSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDR 1226 Query: 433 ILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLE-- 490 +L VNG + G T ++ V LR+T G+ L++ + + + P C Sbjct: 1227 VLAVNGVSLEGATHKQAVETLRNT--GQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQ 1284 Query: 491 ------------------TSEQLTFEIPL-NDSGSAGLGVSLKGNKSRETGTDLGIFIKS 531 +E+ TFE+ L +S G S + N E + +K Sbjct: 1285 GQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKK 1344 Query: 532 IIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLR 571 + G A + G++ + D ++ VNG SL G S E + LR Sbjct: 1345 LFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALR 1384 Score = 57.8 bits (138), Expect = 6e-08 Identities = 95/437 (21%), Positives = 168/437 (38%), Gaps = 81/437 (18%) Query: 163 LKLVVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFS 222 L++ S Q+ +D +VL+ + +++SP + TL ++ + + LG ++ Sbjct: 869 LQMRARQSNQDAQDIDVLHK-RWSIVSSPEREITLVNLKKDAKYG-----LGFQIIG--G 920 Query: 223 SLSGRI-LGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQA---- 277 GR+ LG+FI + + +G + ++ +N+V L + A ++ + A Sbjct: 921 EKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDV 980 Query: 278 -----------MKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNND------GVLKTKVPP 320 K PS +H+ + S + I ++ G L+ Sbjct: 981 TLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISEN 1040 Query: 321 PVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSL--SPLMGFGSNKN 378 GL+ +L+ DS AS S Q LG + S SP S Sbjct: 1041 SFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKAT 1100 Query: 379 AKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNG 438 K+ D + S PG V + +G + D S + Sbjct: 1101 EKETFTD-------------SNQSKTKKPGISDVTDYSDRGDSDMDEATYSSSQD----- 1142 Query: 439 RDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFE 498 T + E++S V + +F + P + + E Sbjct: 1143 ---------------HQTPKQESSSSVNTSNKMNF--KTFSSSPP------KPGDIFEVE 1179 Query: 499 IPLNDSGSAGLGVSLKG--NKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGE 556 + ND+ LG+S+ G N S G GI++K++I GAA DGR+ D+++AVNG Sbjct: 1180 LAKNDNS---LGISVTGGVNTSVRHG---GIYVKAVIPQGAAESDGRIHKGDRVLAVNGV 1233 Query: 557 SLLGKSNHEAMETLRRS 573 SL G ++ +A+ETLR + Sbjct: 1234 SLEGATHKQAVETLRNT 1250 Score = 55.5 bits (132), Expect = 3e-07 Identities = 65/311 (20%), Positives = 118/311 (37%), Gaps = 68/311 (21%) Query: 204 VEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLV 263 VE++ LGI V ++ S R G++++ + ++ +G H+ + ++ +N V L Sbjct: 1178 VELAKNDNSLGISVTGGVNT-SVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLE 1236 Query: 264 DKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVH 323 T QA + R + ++H+L + + K + PV Sbjct: 1237 GATHKQAVETLRNTGQ----VVHLLLEKGQSPTSKEHV-------------------PVT 1273 Query: 324 GKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIK 383 + L N G + + ++ F + +N ++K Sbjct: 1274 PQCTLSDQNAQGQGPEKVKKTTQVKD---------------------YSFVTEENTFEVK 1312 Query: 384 IDLKKGPEGLGFTVVTRDSSIH---GPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440 L K GLGF+ D+ I + VK + P A + G++ GD IL+VNG Sbjct: 1313 --LFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1370 Query: 441 VTGRTQEELVAMLRST----------------KQGETASLVIARQEGHFLPRELK--GEP 482 + G +Q+E+++ LR T + +TA L + LP K +P Sbjct: 1371 LKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQP 1430 Query: 483 DCCALSLETSE 493 C S + E Sbjct: 1431 SCVEQSTSSDE 1441 Score = 49.7 bits (117), Expect = 2e-05 Identities = 73/286 (25%), Positives = 113/286 (39%), Gaps = 37/286 (12%) Query: 381 KIKIDLKKGPEG-LGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGR 439 ++ I L K +G LGFTV + I +V +++ + A DGRL+ GDR+++VN Sbjct: 1595 ELLITLIKSEKGSLGFTVTKGNQRIG----CYVHDVI-QDPAKSDGRLKPGDRLIKVNDT 1649 Query: 440 DVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEI 499 DVT T + V +LR+ +T LVI R LPR + L +I Sbjct: 1650 DVTNMTHTDAVNLLRAA--SKTVRLVIGRVLE--LPR------------IPMLPHLLPDI 1693 Query: 500 PLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLL 559 L LG SL G ++I I A +G L++ D + VNG S Sbjct: 1694 TLT-CNKEELGFSLCGGHDSLYQV---VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQ 1749 Query: 560 GKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAE---------CGAFSKPCF 610 G + E L S+ L ++ +R + G+ S+P Sbjct: 1750 GMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPAL 1809 Query: 611 ENCQNAVTTSRRNDNSILHPLGTCSPQD--KQKGLLLPNDGWAESE 654 + T + N I +P G CS L LP + + + + Sbjct: 1810 TPNDSFSTVAGEEINEISYPKGKCSTYQIKGSPNLTLPKESYIQED 1855 Score = 34.7 bits (78), Expect = 0.51 Identities = 29/107 (27%), Positives = 49/107 (45%), Gaps = 12/107 (11%) Query: 490 ETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQ 549 E +L + ++ GS G V+ KGN+ +G ++ +I A DGRL+ D+ Sbjct: 1591 ELEVELLITLIKSEKGSLGFTVT-KGNQR------IGCYVHDVIQDPAK-SDGRLKPGDR 1642 Query: 550 LIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPM 596 LI VN + ++ +A+ LR + + G +L P PM Sbjct: 1643 LIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR----VLELPRIPM 1685 Score = 33.1 bits (74), Expect = 1.5 Identities = 35/122 (28%), Positives = 53/122 (43%), Gaps = 22/122 (18%) Query: 332 NLTGTDSPETDASAS----LQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLK 387 N+T TD+ +AS L + +PR+ P P L P + NK Sbjct: 1653 NMTHTDAVNLLRAASKTVRLVIGRVLELPRI---PMLPHLLPDITLTCNK---------- 1699 Query: 388 KGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQE 447 E LGF++ S++ +++ +I P+ A +G LQ D I VNG G T E Sbjct: 1700 ---EELGFSLCGGHDSLYQV--VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLE 1754 Query: 448 EL 449 E+ Sbjct: 1755 EV 1756 >gi|18375646 protein tyrosine phosphatase, non-receptor type 13 isoform 1 [Homo sapiens] Length = 2485 Score = 83.2 bits (204), Expect = 1e-15 Identities = 72/280 (25%), Positives = 121/280 (43%), Gaps = 30/280 (10%) Query: 315 KTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG 374 KTK P G S + + G + +S Q +++P+ +S ++ F Sbjct: 1303 KTKKP----GISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMN-FKTFS 1357 Query: 375 SN--KNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDR 432 S+ K +++L K LG +V ++ G I+VK ++P+GAA DGR+ GDR Sbjct: 1358 SSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDR 1417 Query: 433 ILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLE-- 490 +L VNG + G T ++ V LR+T G+ L++ + + + P C Sbjct: 1418 VLAVNGVSLEGATHKQAVETLRNT--GQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQ 1475 Query: 491 ------------------TSEQLTFEIPL-NDSGSAGLGVSLKGNKSRETGTDLGIFIKS 531 +E+ TFE+ L +S G S + N E + +K Sbjct: 1476 GQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKK 1535 Query: 532 IIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLR 571 + G A + G++ + D ++ VNG SL G S E + LR Sbjct: 1536 LFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALR 1575 Score = 55.5 bits (132), Expect = 3e-07 Identities = 65/311 (20%), Positives = 118/311 (37%), Gaps = 68/311 (21%) Query: 204 VEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLV 263 VE++ LGI V ++ S R G++++ + ++ +G H+ + ++ +N V L Sbjct: 1369 VELAKNDNSLGISVTGGVNT-SVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLE 1427 Query: 264 DKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVH 323 T QA + R + ++H+L + + K + PV Sbjct: 1428 GATHKQAVETLRNTGQ----VVHLLLEKGQSPTSKEHV-------------------PVT 1464 Query: 324 GKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIK 383 + L N G + + ++ F + +N ++K Sbjct: 1465 PQCTLSDQNAQGQGPEKVKKTTQVKD---------------------YSFVTEENTFEVK 1503 Query: 384 IDLKKGPEGLGFTVVTRDSSIH---GPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440 L K GLGF+ D+ I + VK + P A + G++ GD IL+VNG Sbjct: 1504 --LFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1561 Query: 441 VTGRTQEELVAMLRST----------------KQGETASLVIARQEGHFLPRELK--GEP 482 + G +Q+E+++ LR T + +TA L + LP K +P Sbjct: 1562 LKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQP 1621 Query: 483 DCCALSLETSE 493 C S + E Sbjct: 1622 SCVEQSTSSDE 1632 Score = 54.7 bits (130), Expect = 5e-07 Identities = 33/79 (41%), Positives = 52/79 (65%), Gaps = 6/79 (7%) Query: 497 FEIPLNDSGSAGLGVSLKG--NKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVN 554 FE+ L + ++ LG+S+ G N S G GI++K++I GAA DGR+ D+++AVN Sbjct: 1367 FEVELAKNDNS-LGISVTGGVNTSVRHG---GIYVKAVIPQGAAESDGRIHKGDRVLAVN 1422 Query: 555 GESLLGKSNHEAMETLRRS 573 G SL G ++ +A+ETLR + Sbjct: 1423 GVSLEGATHKQAVETLRNT 1441 Score = 52.0 bits (123), Expect = 3e-06 Identities = 31/75 (41%), Positives = 42/75 (56%), Gaps = 1/75 (1%) Query: 499 IPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESL 558 + L GLG + G + DLGIFI S+ GG A DG L+ D+LI+VN SL Sbjct: 1094 VNLKKDAKYGLGFQIIGGEKMGR-LDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSL 1152 Query: 559 LGKSNHEAMETLRRS 573 G S+H A+E L+ + Sbjct: 1153 EGVSHHAAIEILQNA 1167 Score = 49.7 bits (117), Expect = 2e-05 Identities = 73/286 (25%), Positives = 113/286 (39%), Gaps = 37/286 (12%) Query: 381 KIKIDLKKGPEG-LGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGR 439 ++ I L K +G LGFTV + I +V +++ + A DGRL+ GDR+++VN Sbjct: 1786 ELLITLIKSEKGSLGFTVTKGNQRIG----CYVHDVI-QDPAKSDGRLKPGDRLIKVNDT 1840 Query: 440 DVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEI 499 DVT T + V +LR+ +T LVI R LPR + L +I Sbjct: 1841 DVTNMTHTDAVNLLRAA--SKTVRLVIGRVLE--LPR------------IPMLPHLLPDI 1884 Query: 500 PLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLL 559 L LG SL G ++I I A +G L++ D + VNG S Sbjct: 1885 TLT-CNKEELGFSLCGGHDSLYQV---VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQ 1940 Query: 560 GKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAE---------CGAFSKPCF 610 G + E L S+ L ++ +R + G+ S+P Sbjct: 1941 GMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPAL 2000 Query: 611 ENCQNAVTTSRRNDNSILHPLGTCSPQD--KQKGLLLPNDGWAESE 654 + T + N I +P G CS L LP + + + + Sbjct: 2001 TPNDSFSTVAGEEINEISYPKGKCSTYQIKGSPNLTLPKESYIQED 2046 Score = 41.6 bits (96), Expect = 0.004 Identities = 26/86 (30%), Positives = 47/86 (54%), Gaps = 3/86 (3%) Query: 384 IDLKKGPE-GLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVT 442 ++LKK + GLGF ++ + IF+ ++ P G A DG L+ GDR++ VN + Sbjct: 1094 VNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 1153 Query: 443 GRTQEELVAMLRSTKQGETASLVIAR 468 G + + +L++ E +LVI++ Sbjct: 1154 GVSHHAAIEILQNAP--EDVTLVISQ 1177 Score = 34.7 bits (78), Expect = 0.51 Identities = 29/107 (27%), Positives = 49/107 (45%), Gaps = 12/107 (11%) Query: 490 ETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQ 549 E +L + ++ GS G V+ KGN+ +G ++ +I A DGRL+ D+ Sbjct: 1782 ELEVELLITLIKSEKGSLGFTVT-KGNQR------IGCYVHDVIQDPAK-SDGRLKPGDR 1833 Query: 550 LIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPM 596 LI VN + ++ +A+ LR + + G +L P PM Sbjct: 1834 LIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR----VLELPRIPM 1876 Score = 33.1 bits (74), Expect = 1.5 Identities = 35/122 (28%), Positives = 53/122 (43%), Gaps = 22/122 (18%) Query: 332 NLTGTDSPETDASAS----LQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLK 387 N+T TD+ +AS L + +PR+ P P L P + NK Sbjct: 1844 NMTHTDAVNLLRAASKTVRLVIGRVLELPRI---PMLPHLLPDITLTCNK---------- 1890 Query: 388 KGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQE 447 E LGF++ S++ +++ +I P+ A +G LQ D I VNG G T E Sbjct: 1891 ---EELGFSLCGGHDSLYQV--VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLE 1945 Query: 448 EL 449 E+ Sbjct: 1946 EV 1947 >gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform 2 [Homo sapiens] Length = 2466 Score = 83.2 bits (204), Expect = 1e-15 Identities = 72/280 (25%), Positives = 121/280 (43%), Gaps = 30/280 (10%) Query: 315 KTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG 374 KTK P G S + + G + +S Q +++P+ +S ++ F Sbjct: 1284 KTKKP----GISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMN-FKTFS 1338 Query: 375 SN--KNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDR 432 S+ K +++L K LG +V ++ G I+VK ++P+GAA DGR+ GDR Sbjct: 1339 SSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDR 1398 Query: 433 ILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLE-- 490 +L VNG + G T ++ V LR+T G+ L++ + + + P C Sbjct: 1399 VLAVNGVSLEGATHKQAVETLRNT--GQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQ 1456 Query: 491 ------------------TSEQLTFEIPL-NDSGSAGLGVSLKGNKSRETGTDLGIFIKS 531 +E+ TFE+ L +S G S + N E + +K Sbjct: 1457 GQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKK 1516 Query: 532 IIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLR 571 + G A + G++ + D ++ VNG SL G S E + LR Sbjct: 1517 LFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALR 1556 Score = 55.5 bits (132), Expect = 3e-07 Identities = 65/311 (20%), Positives = 118/311 (37%), Gaps = 68/311 (21%) Query: 204 VEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLV 263 VE++ LGI V ++ S R G++++ + ++ +G H+ + ++ +N V L Sbjct: 1350 VELAKNDNSLGISVTGGVNT-SVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLE 1408 Query: 264 DKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVH 323 T QA + R + ++H+L + + K + PV Sbjct: 1409 GATHKQAVETLRNTGQ----VVHLLLEKGQSPTSKEHV-------------------PVT 1445 Query: 324 GKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIK 383 + L N G + + ++ F + +N ++K Sbjct: 1446 PQCTLSDQNAQGQGPEKVKKTTQVKD---------------------YSFVTEENTFEVK 1484 Query: 384 IDLKKGPEGLGFTVVTRDSSIH---GPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440 L K GLGF+ D+ I + VK + P A + G++ GD IL+VNG Sbjct: 1485 --LFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1542 Query: 441 VTGRTQEELVAMLRST----------------KQGETASLVIARQEGHFLPRELK--GEP 482 + G +Q+E+++ LR T + +TA L + LP K +P Sbjct: 1543 LKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQP 1602 Query: 483 DCCALSLETSE 493 C S + E Sbjct: 1603 SCVEQSTSSDE 1613 Score = 54.7 bits (130), Expect = 5e-07 Identities = 33/79 (41%), Positives = 52/79 (65%), Gaps = 6/79 (7%) Query: 497 FEIPLNDSGSAGLGVSLKG--NKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVN 554 FE+ L + ++ LG+S+ G N S G GI++K++I GAA DGR+ D+++AVN Sbjct: 1348 FEVELAKNDNS-LGISVTGGVNTSVRHG---GIYVKAVIPQGAAESDGRIHKGDRVLAVN 1403 Query: 555 GESLLGKSNHEAMETLRRS 573 G SL G ++ +A+ETLR + Sbjct: 1404 GVSLEGATHKQAVETLRNT 1422 Score = 52.0 bits (123), Expect = 3e-06 Identities = 31/75 (41%), Positives = 42/75 (56%), Gaps = 1/75 (1%) Query: 499 IPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESL 558 + L GLG + G + DLGIFI S+ GG A DG L+ D+LI+VN SL Sbjct: 1075 VNLKKDAKYGLGFQIIGGEKMGR-LDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSL 1133 Query: 559 LGKSNHEAMETLRRS 573 G S+H A+E L+ + Sbjct: 1134 EGVSHHAAIEILQNA 1148 Score = 49.7 bits (117), Expect = 2e-05 Identities = 73/286 (25%), Positives = 113/286 (39%), Gaps = 37/286 (12%) Query: 381 KIKIDLKKGPEG-LGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGR 439 ++ I L K +G LGFTV + I +V +++ + A DGRL+ GDR+++VN Sbjct: 1767 ELLITLIKSEKGSLGFTVTKGNQRIG----CYVHDVI-QDPAKSDGRLKPGDRLIKVNDT 1821 Query: 440 DVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEI 499 DVT T + V +LR+ +T LVI R LPR + L +I Sbjct: 1822 DVTNMTHTDAVNLLRAA--SKTVRLVIGRVLE--LPR------------IPMLPHLLPDI 1865 Query: 500 PLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLL 559 L LG SL G ++I I A +G L++ D + VNG S Sbjct: 1866 TLT-CNKEELGFSLCGGHDSLYQV---VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQ 1921 Query: 560 GKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAE---------CGAFSKPCF 610 G + E L S+ L ++ +R + G+ S+P Sbjct: 1922 GMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPAL 1981 Query: 611 ENCQNAVTTSRRNDNSILHPLGTCSPQD--KQKGLLLPNDGWAESE 654 + T + N I +P G CS L LP + + + + Sbjct: 1982 TPNDSFSTVAGEEINEISYPKGKCSTYQIKGSPNLTLPKESYIQED 2027 Score = 41.6 bits (96), Expect = 0.004 Identities = 26/86 (30%), Positives = 47/86 (54%), Gaps = 3/86 (3%) Query: 384 IDLKKGPE-GLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVT 442 ++LKK + GLGF ++ + IF+ ++ P G A DG L+ GDR++ VN + Sbjct: 1075 VNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 1134 Query: 443 GRTQEELVAMLRSTKQGETASLVIAR 468 G + + +L++ E +LVI++ Sbjct: 1135 GVSHHAAIEILQNAP--EDVTLVISQ 1158 Score = 34.7 bits (78), Expect = 0.51 Identities = 29/107 (27%), Positives = 49/107 (45%), Gaps = 12/107 (11%) Query: 490 ETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQ 549 E +L + ++ GS G V+ KGN+ +G ++ +I A DGRL+ D+ Sbjct: 1763 ELEVELLITLIKSEKGSLGFTVT-KGNQR------IGCYVHDVIQDPAK-SDGRLKPGDR 1814 Query: 550 LIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPM 596 LI VN + ++ +A+ LR + + G +L P PM Sbjct: 1815 LIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR----VLELPRIPM 1857 Score = 33.1 bits (74), Expect = 1.5 Identities = 35/122 (28%), Positives = 53/122 (43%), Gaps = 22/122 (18%) Query: 332 NLTGTDSPETDASAS----LQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLK 387 N+T TD+ +AS L + +PR+ P P L P + NK Sbjct: 1825 NMTHTDAVNLLRAASKTVRLVIGRVLELPRI---PMLPHLLPDITLTCNK---------- 1871 Query: 388 KGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQE 447 E LGF++ S++ +++ +I P+ A +G LQ D I VNG G T E Sbjct: 1872 ---EELGFSLCGGHDSLYQV--VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLE 1926 Query: 448 EL 449 E+ Sbjct: 1927 EV 1928 >gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] Length = 904 Score = 82.4 bits (202), Expect = 2e-15 Identities = 71/228 (31%), Positives = 111/228 (48%), Gaps = 30/228 (13%) Query: 353 PRVPRLGGKP---SSPSL-SPLMGFGSNKNAKKIKIDLKKGPEGLGFTVV--TRDSSIHG 406 P +P+ P ++ SL +P G++ + + +I L++G GLGF++ T + I Sbjct: 190 PTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGD 249 Query: 407 PGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVI 466 IF+ I+ GAA +DGRL+ D IL VN DV T + V L+ G L + Sbjct: 250 DSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEA--GSIVRLYV 307 Query: 467 ARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRE-TGTDL 525 R++ SE++ EI L G GLG S+ G + D Sbjct: 308 KRRK-------------------PVSEKI-MEIKLI-KGPKGLGFSIAGGVGNQHIPGDN 346 Query: 526 GIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 573 I++ II GGAA KDG+L++ D+L+AVN L ++ EA+ L+ + Sbjct: 347 SIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNT 394 Score = 81.3 bits (199), Expect = 5e-15 Identities = 83/304 (27%), Positives = 130/304 (42%), Gaps = 49/304 (16%) Query: 380 KKIKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGDRILEVN 437 K ++I L KGP+GLGF++ + H PG I+V I+ GAA KDG+LQ GD++L VN Sbjct: 316 KIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVN 375 Query: 438 GRDVTGRTQEELVAMLRSTKQGETASLVIARQ----------------------EGHFLP 475 + T EE V L++T + L +A+ + H P Sbjct: 376 NVCLEEVTHEEAVTALKNTS--DFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSP 433 Query: 476 RELKGEPDCC-------ALSLETSEQLTFE---IPLNDSGSAGLGVSLKGNKSRETGTDL 525 G+ + ++ +++T E + L+ GS GLG ++ G + E Sbjct: 434 SSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLH-RGSTGLGFNIVGGEDGE----- 487 Query: 526 GIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQ 585 GIFI I+ GG A G LR D++I+VN L S+ +A L+ N + Sbjct: 488 GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALK-------NAGQAVT 540 Query: 586 LVILRRPERPMEDPAECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLL 645 +V RPE A+ + + ++ + S R + DK K L Sbjct: 541 IVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGL 600 Query: 646 PNDG 649 P+ G Sbjct: 601 PSQG 604 Score = 55.1 bits (131), Expect = 4e-07 Identities = 33/85 (38%), Positives = 50/85 (58%), Gaps = 6/85 (7%) Query: 493 EQLTFEIPLNDSGSAGLGVSLKGNKSR-ETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLI 551 E++T E G++GLG S+ G G D IFI II GGAA +DGRLR+ND ++ Sbjct: 223 EEITLE-----RGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCIL 277 Query: 552 AVNGESLLGKSNHEAMETLRRSMSM 576 VN + ++ +A+E L+ + S+ Sbjct: 278 RVNEVDVRDVTHSKAVEALKEAGSI 302 Score = 52.4 bits (124), Expect = 2e-06 Identities = 46/152 (30%), Positives = 70/152 (46%), Gaps = 15/152 (9%) Query: 314 LKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPS-LSPLMG 372 LK P ++ G ++T + S D S LG P+SP+ SP+ Sbjct: 400 LKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSF-------LGQTPASPARYSPVSK 452 Query: 373 --FGSNKNAKKI-KIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQS 429 G ++ ++ K+ L +G GLGF +V + G G IF+ IL G A G L+ Sbjct: 453 AVLGDDEITREPRKVVLHRGSTGLGFNIVGGED---GEG-IFISFILAGGPADLSGELRK 508 Query: 430 GDRILEVNGRDVTGRTQEELVAMLRSTKQGET 461 GDRI+ VN D+ + E+ A L++ Q T Sbjct: 509 GDRIISVNSVDLRAASHEQAAAALKNAGQAVT 540 Score = 33.9 bits (76), Expect = 0.87 Identities = 14/47 (29%), Positives = 28/47 (59%) Query: 231 LFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQA 277 +FI I + ++G N+CI+++N VD+ D T ++A + ++A Sbjct: 253 IFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEA 299 >gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapiens] Length = 767 Score = 82.0 bits (201), Expect = 3e-15 Identities = 72/237 (30%), Positives = 105/237 (44%), Gaps = 54/237 (22%) Query: 380 KKIKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGDRILEVN 437 K ++I L KGP+GLGF++ + H PG I+V I+ GAA KDGRLQ GD+IL VN Sbjct: 200 KVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVN 259 Query: 438 GRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTF 497 + E+ VA L++T + L +A+ +L + PD ++ S+ L Sbjct: 260 SVGLEDVMHEDAVAALKNTY--DVVYLKVAKPSNAYL-SDSYAPPD---ITTSYSQHLDN 313 Query: 498 EIPLND-----------------------------------------SGSAGLGVSLKGN 516 EI + GS GLG ++ G Sbjct: 314 EISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGG 373 Query: 517 KSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 573 + E GIFI I+ GG A G LR DQ+++VNG L S+ +A L+ + Sbjct: 374 EDGE-----GIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNA 425 Score = 80.1 bits (196), Expect = 1e-14 Identities = 63/194 (32%), Positives = 92/194 (47%), Gaps = 26/194 (13%) Query: 383 KIDLKKGPEGLGFTVVTRDSSIH-GPGP-IFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440 +I L++G GLGF++ + H G P IF+ I+P GAA +DGRL+ D IL VN D Sbjct: 108 EITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVD 167 Query: 441 VTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIP 500 V T V L+ G L + R++ + EI Sbjct: 168 VREVTHSAAVEALKEA--GSIVRLYVMRRK--------------------PPAEKVMEIK 205 Query: 501 LNDSGSAGLGVSLKGNKSRE-TGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLL 559 L G GLG S+ G + D I++ II GGAA KDGRL++ D+++AVN L Sbjct: 206 LI-KGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLE 264 Query: 560 GKSNHEAMETLRRS 573 + +A+ L+ + Sbjct: 265 DVMHEDAVAALKNT 278 Score = 57.0 bits (136), Expect = 1e-07 Identities = 35/102 (34%), Positives = 57/102 (55%), Gaps = 8/102 (7%) Query: 491 TSEQLTFEIPLNDSGSAGLGVSLKGNKSR-ETGTDLGIFIKSIIHGGAAFKDGRLRMNDQ 549 T ++ +E + G++GLG S+ G G D IFI II GGAA +DGRLR+ND Sbjct: 100 TEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDS 159 Query: 550 LIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRR 591 ++ VN + ++ A+E L+ + S +++L ++RR Sbjct: 160 ILFVNEVDVREVTHSAAVEALKEAGS-------IVRLYVMRR 194 Score = 48.5 bits (114), Expect = 3e-05 Identities = 102/441 (23%), Positives = 161/441 (36%), Gaps = 79/441 (17%) Query: 58 ILDPDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFK- 116 +LD D + + K E+ PL SP+ P SP + ++ Sbjct: 38 LLDILDYYEASLSESQKYRYQDEDTPPLE--HSPAHLPNQANSPPVIVNTDTLEAPGYEL 95 Query: 117 ---PIGGEIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASH----PGG---QSLKLV 166 GE+E L+ G L + P PS PGG Q +L Sbjct: 96 QVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLR 155 Query: 167 VPDS---TQNLEDREVLNGVQTELLTSPRTKDTLSDMTR------TVEISGEGGPLGIHV 217 V DS ++ REV + E L + L M R +EI GP G+ Sbjct: 156 VNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLG- 214 Query: 218 VPFFSSLSG----RILG---LFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQA 270 FS G I G +++ I + + ++G + I+ +N+V L D A Sbjct: 215 ---FSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDA 271 Query: 271 QDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPV------HG 324 + V L V P N + + PP + H Sbjct: 272 VAALKNTYDV--VYLKVAKPSNAYLSD------------------SYAPPDITTSYSQHL 311 Query: 325 KSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKI 384 + + ++ GTD P T + + + SP L G+ P + +I Sbjct: 312 DNEISHSSYLGTDYP-TAMTPTSPRRYSPVAKDLLGEEDIPR-------------EPRRI 357 Query: 385 DLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGR 444 + +G GLGF +V + G G IF+ IL G A G L+ GD+IL VNG D+ Sbjct: 358 VIHRGSTGLGFNIVGGED---GEG-IFISFILAGGPADLSGELRKGDQILSVNGVDLRNA 413 Query: 445 TQEELVAMLRSTKQGETASLV 465 + E+ L++ G+T +++ Sbjct: 414 SHEQAAIALKNA--GQTVTII 432 >gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sapiens] Length = 721 Score = 82.0 bits (201), Expect = 3e-15 Identities = 72/237 (30%), Positives = 105/237 (44%), Gaps = 54/237 (22%) Query: 380 KKIKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGDRILEVN 437 K ++I L KGP+GLGF++ + H PG I+V I+ GAA KDGRLQ GD+IL VN Sbjct: 154 KVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVN 213 Query: 438 GRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTF 497 + E+ VA L++T + L +A+ +L + PD ++ S+ L Sbjct: 214 SVGLEDVMHEDAVAALKNTY--DVVYLKVAKPSNAYL-SDSYAPPD---ITTSYSQHLDN 267 Query: 498 EIPLND-----------------------------------------SGSAGLGVSLKGN 516 EI + GS GLG ++ G Sbjct: 268 EISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGG 327 Query: 517 KSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 573 + E GIFI I+ GG A G LR DQ+++VNG L S+ +A L+ + Sbjct: 328 EDGE-----GIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNA 379 Score = 80.1 bits (196), Expect = 1e-14 Identities = 63/194 (32%), Positives = 92/194 (47%), Gaps = 26/194 (13%) Query: 383 KIDLKKGPEGLGFTVVTRDSSIH-GPGP-IFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440 +I L++G GLGF++ + H G P IF+ I+P GAA +DGRL+ D IL VN D Sbjct: 62 EITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVD 121 Query: 441 VTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIP 500 V T V L+ G L + R++ + EI Sbjct: 122 VREVTHSAAVEALKEA--GSIVRLYVMRRK--------------------PPAEKVMEIK 159 Query: 501 LNDSGSAGLGVSLKGNKSRE-TGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLL 559 L G GLG S+ G + D I++ II GGAA KDGRL++ D+++AVN L Sbjct: 160 LI-KGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLE 218 Query: 560 GKSNHEAMETLRRS 573 + +A+ L+ + Sbjct: 219 DVMHEDAVAALKNT 232 Score = 57.0 bits (136), Expect = 1e-07 Identities = 35/102 (34%), Positives = 57/102 (55%), Gaps = 8/102 (7%) Query: 491 TSEQLTFEIPLNDSGSAGLGVSLKGNKSR-ETGTDLGIFIKSIIHGGAAFKDGRLRMNDQ 549 T ++ +E + G++GLG S+ G G D IFI II GGAA +DGRLR+ND Sbjct: 54 TEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDS 113 Query: 550 LIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRR 591 ++ VN + ++ A+E L+ + S +++L ++RR Sbjct: 114 ILFVNEVDVREVTHSAAVEALKEAGS-------IVRLYVMRR 148 Score = 49.7 bits (117), Expect = 2e-05 Identities = 99/416 (23%), Positives = 153/416 (36%), Gaps = 76/416 (18%) Query: 80 EEQEPLHKIESPSGNPADRQSPDAF-ETEVAAQLAAFKPIGGEIEVTPSALKLGTPLLVR 138 E+ PL SP+ P SP T+ GE+E L+ G L Sbjct: 17 EDTPPLE--HSPAHLPNQANSPPVIVNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGF 74 Query: 139 RSSDPVPGPPADTQPSASH----PGG---QSLKLVVPDS---TQNLEDREVLNGVQTELL 188 + P PS PGG Q +L V DS ++ REV + E L Sbjct: 75 SIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEAL 134 Query: 189 TSPRTKDTLSDMTR------TVEISGEGGPLGIHVVPFFSSLSG----RILG---LFIRG 235 + L M R +EI GP G+ FS G I G +++ Sbjct: 135 KEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLG----FSIAGGVGNQHIPGDNSIYVTK 190 Query: 236 IEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQ 295 I + + ++G + I+ +N+V L D A + V L V P N Sbjct: 191 IIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDV--VYLKVAKPSNAYL 248 Query: 296 YEKSVIGSLNIFGNNDGVLKTKVPPPV------HGKSGLKTANLTGTDSPETDASASLQQ 349 + + PP + H + + ++ GTD P T + + + Sbjct: 249 SD------------------SYAPPDITTSYSQHLDNEISHSSYLGTDYP-TAMTPTSPR 289 Query: 350 NKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGP 409 SP L G+ P + +I + +G GLGF +V + G G Sbjct: 290 RYSPVAKDLLGEEDIPR-------------EPRRIVIHRGSTGLGFNIVGGED---GEG- 332 Query: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLV 465 IF+ IL G A G L+ GD+IL VNG D+ + E+ L++ G+T +++ Sbjct: 333 IFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNA--GQTVTII 386 >gi|148833504 interleukin 16 isoform 2 [Homo sapiens] Length = 1332 Score = 82.0 bits (201), Expect = 3e-15 Identities = 59/192 (30%), Positives = 90/192 (46%), Gaps = 25/192 (13%) Query: 386 LKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRT 445 +K +GLGF++V SI+GP I+VK I GAA DGRLQ GD ILE+NG + G T Sbjct: 220 MKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLT 279 Query: 446 QEELVAMLRSTKQGETASLVIARQE------GHFLP---RELKGE----PDCCALSLET- 491 ++ + + K+G V R H P R L D + +LE+ Sbjct: 280 HQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESP 339 Query: 492 ---------SEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDG 542 + ++ E+ L GLG+ L + + GIF+ ++ G A DG Sbjct: 340 SAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCIS--GIFVHTLSPGSVAHLDG 397 Query: 543 RLRMNDQLIAVN 554 RLR D+++ ++ Sbjct: 398 RLRCGDEIVEIS 409 Score = 71.2 bits (173), Expect = 5e-12 Identities = 51/198 (25%), Positives = 94/198 (47%), Gaps = 15/198 (7%) Query: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469 I V + P G A ++G +Q G+ +L +NG+ + G T + +A+LR ++ A +V + Sbjct: 1139 ITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKL 1198 Query: 470 EGHFLPRELKGEPDCCA-------LSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETG 522 +P +L D A +S+E++ + T + SAGLG SL+G K G Sbjct: 1199 TPEAMP-DLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHG 1257 Query: 523 TDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRG 582 D + I I G A+ + ++ D+++ + G ++ G + EA ++ G Sbjct: 1258 -DKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPD------G 1310 Query: 583 MIQLVILRRPERPMEDPA 600 + +VI R+ + E A Sbjct: 1311 PVTIVIRRKSLQSKETTA 1328 Score = 63.5 bits (153), Expect = 1e-09 Identities = 40/142 (28%), Positives = 73/142 (51%), Gaps = 14/142 (9%) Query: 499 IPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESL 558 I L + GLG S+ G K G +GI++K+I GGAA DGRL+ D+++ +NGES+ Sbjct: 217 IVLMKGQAKGLGFSIVGGKDSIYGP-IGIYVKTIFAGGAAAADGRLQEGDEILELNGESM 275 Query: 559 LGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKPCFENCQNAVT 618 G ++ +A++ +++ +G++ L + R P P+ C S P + ++ Sbjct: 276 AGLTHQDALQKFKQAK------KGLLTLTVRTRLTAP---PSLCSHLSPPLCRSLSSSTC 326 Query: 619 TSRRNDNSILH----PLGTCSP 636 ++ + + L P+ T P Sbjct: 327 ITKDSSSFALESPSAPISTAKP 348 Score = 46.2 bits (108), Expect = 2e-04 Identities = 36/144 (25%), Positives = 63/144 (43%), Gaps = 17/144 (11%) Query: 342 DASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG----------------SNKNAKKIKID 385 DA A L+Q + PR + + +P P + S A + Sbjct: 1177 DALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVT 1236 Query: 386 LKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRT 445 L+K GLGF++ S+HG P+ + I A+ + +Q GD IL++ G + G T Sbjct: 1237 LEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLT 1296 Query: 446 QEELVAMLRSTKQGETASLVIARQ 469 + E ++++ G ++VI R+ Sbjct: 1297 RFEAWNIIKALPDG-PVTIVIRRK 1319 Score = 45.4 bits (106), Expect = 3e-04 Identities = 67/300 (22%), Positives = 114/300 (38%), Gaps = 48/300 (16%) Query: 183 VQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRS 242 + T L P S ++ V + G+ LG +V S+ G I G++++ I + Sbjct: 197 LSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPI-GIYVKTIFAGGAA 255 Query: 243 KREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIG 302 +G E + I+++N + T A F+QA K L L + R S+ Sbjct: 256 AADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKG----LLTLTVRTRLTAPPSLCS 311 Query: 303 SLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKP 362 L+ PP+ +L+ + D+S+ + SP P KP Sbjct: 312 HLS--------------PPL-------CRSLSSSTCITKDSSSFALE--SPSAPISTAKP 348 Query: 363 SSPSLSPLMGFGSNKNAKKIKIDLKKGPE---GLGFTVVTRDSSIHGPGPIFVKNILPKG 419 + + +++ L+K G+G V I G IFV + P Sbjct: 349 NYRIM--------------VEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGS 391 Query: 420 AAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELK 479 A DGRL+ GD I+E++ V T E+ +L G +V + ++LK Sbjct: 392 VAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLK 451 >gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] Length = 749 Score = 80.9 bits (198), Expect = 6e-15 Identities = 67/194 (34%), Positives = 96/194 (49%), Gaps = 26/194 (13%) Query: 383 KIDLKKGPEGLGFTVVTRDSSIH-GPGP-IFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440 +I L++G GLGF++ + H G P IF+ I+P GAA +DGRL+ D IL VN D Sbjct: 47 EITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVD 106 Query: 441 VTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIP 500 V+ + + V L+ G L + R+ LET EI Sbjct: 107 VSEVSHSKAVEALKEA--GSIVRLYVRRRRP----------------ILET----VVEIK 144 Query: 501 LNDSGSAGLGVSLKGNKSRE-TGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLL 559 L G GLG S+ G + D I++ II GGAA KDGRL++ D+L+ VN SL Sbjct: 145 LF-KGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLE 203 Query: 560 GKSNHEAMETLRRS 573 ++ EA+ L+ + Sbjct: 204 EVTHEEAVAILKNT 217 Score = 66.6 bits (161), Expect = 1e-10 Identities = 37/79 (46%), Positives = 51/79 (64%), Gaps = 2/79 (2%) Query: 382 IKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGDRILEVNGR 439 ++I L KGP+GLGF++ + H PG I+V I+ GAA KDGRLQ GDR+L VN Sbjct: 141 VEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNY 200 Query: 440 DVTGRTQEELVAMLRSTKQ 458 + T EE VA+L++T + Sbjct: 201 SLEEVTHEEAVAILKNTSE 219 Score = 63.9 bits (154), Expect = 8e-10 Identities = 76/301 (25%), Positives = 126/301 (41%), Gaps = 49/301 (16%) Query: 231 LFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMK-------SPSV 283 +++ I D ++++G + ++ +NN L + T +A + + + P+ Sbjct: 171 IYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTT 230 Query: 284 LLHVLP---PQNREQYEKSVIGSLNIFGNNDGVL--KTKVPPPVHGKSGLKTANLTGTDS 338 + P P Y + L N+G L KT +PP G+ ++ D Sbjct: 231 IYMTDPYGPPDITHSYSPPMENHL--LSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDD- 287 Query: 339 PETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVV 398 D ++ Q + + R P S + + + K+ L KG GLGF +V Sbjct: 288 ---DYTSHSQHSTATRQP-----------SMTLQRAVSLEGEPRKVVLHKGSTGLGFNIV 333 Query: 399 TRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQ 458 + G G IFV IL G A G LQ GD+IL VNG D+ G + E+ A L+ Sbjct: 334 GGED---GEG-IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA-- 387 Query: 459 GETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKS 518 G+T +++ Q + E K + EQ+ +N S S+G G SL+ N+ Sbjct: 388 GQTVTIIAQYQPEDYARFEAKIH--------DLREQM-----MNHSMSSGSG-SLRTNQK 433 Query: 519 R 519 R Sbjct: 434 R 434 Score = 60.1 bits (144), Expect = 1e-08 Identities = 42/119 (35%), Positives = 60/119 (50%), Gaps = 9/119 (7%) Query: 491 TSEQLTFEIPLNDSGSAGLGVSLKGNKSR-ETGTDLGIFIKSIIHGGAAFKDGRLRMNDQ 549 T + FE + G++GLG S+ G G D GIFI II GGAA +DGRLR+ND Sbjct: 39 TEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDC 98 Query: 550 LIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKP 608 ++ VN + S+ +A+E L+ + G I + +RR +E E F P Sbjct: 99 ILRVNEVDVSEVSHSKAVEALKEA--------GSIVRLYVRRRRPILETVVEIKLFKGP 149 Score = 47.8 bits (112), Expect = 6e-05 Identities = 26/67 (38%), Positives = 38/67 (56%), Gaps = 5/67 (7%) Query: 505 GSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNH 564 GS GLG ++ G + E GIF+ I+ GG A G L+ DQ+++VNG L G S+ Sbjct: 324 GSTGLGFNIVGGEDGE-----GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHE 378 Query: 565 EAMETLR 571 +A L+ Sbjct: 379 QAAAALK 385 Score = 33.1 bits (74), Expect = 1.5 Identities = 13/48 (27%), Positives = 28/48 (58%) Query: 230 GLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQA 277 G+FI I + +G N+CI+++N VD+ + + ++A + ++A Sbjct: 75 GIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEA 122 >gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] Length = 975 Score = 80.9 bits (198), Expect = 6e-15 Identities = 67/194 (34%), Positives = 96/194 (49%), Gaps = 26/194 (13%) Query: 383 KIDLKKGPEGLGFTVVTRDSSIH-GPGP-IFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440 +I L++G GLGF++ + H G P IF+ I+P GAA +DGRL+ D IL VN D Sbjct: 203 EITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVD 262 Query: 441 VTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIP 500 V+ + + V L+ G L + R+ LET EI Sbjct: 263 VSEVSHSKAVEALKEA--GSIVRLYVRRRRP----------------ILET----VVEIK 300 Query: 501 LNDSGSAGLGVSLKGNKSRE-TGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLL 559 L G GLG S+ G + D I++ II GGAA KDGRL++ D+L+ VN SL Sbjct: 301 LF-KGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLE 359 Query: 560 GKSNHEAMETLRRS 573 ++ EA+ L+ + Sbjct: 360 EVTHEEAVAILKNT 373 Score = 66.6 bits (161), Expect = 1e-10 Identities = 37/79 (46%), Positives = 51/79 (64%), Gaps = 2/79 (2%) Query: 382 IKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGDRILEVNGR 439 ++I L KGP+GLGF++ + H PG I+V I+ GAA KDGRLQ GDR+L VN Sbjct: 297 VEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNY 356 Query: 440 DVTGRTQEELVAMLRSTKQ 458 + T EE VA+L++T + Sbjct: 357 SLEEVTHEEAVAILKNTSE 375 Score = 60.1 bits (144), Expect = 1e-08 Identities = 42/119 (35%), Positives = 60/119 (50%), Gaps = 9/119 (7%) Query: 491 TSEQLTFEIPLNDSGSAGLGVSLKGNKSR-ETGTDLGIFIKSIIHGGAAFKDGRLRMNDQ 549 T + FE + G++GLG S+ G G D GIFI II GGAA +DGRLR+ND Sbjct: 195 TEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDC 254 Query: 550 LIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKP 608 ++ VN + S+ +A+E L+ + G I + +RR +E E F P Sbjct: 255 ILRVNEVDVSEVSHSKAVEALKEA--------GSIVRLYVRRRRPILETVVEIKLFKGP 305 Score = 57.4 bits (137), Expect = 7e-08 Identities = 49/137 (35%), Positives = 68/137 (49%), Gaps = 20/137 (14%) Query: 383 KIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVT 442 K+ L KG GLGF +V + G G IFV IL G A G LQ GD+IL VNG D+ Sbjct: 526 KVVLHKGSTGLGFNIVGGED---GEG-IFVSFILAGGPADLSGELQRGDQILSVNGIDLR 581 Query: 443 GRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLN 502 G + E+ A L+ G+T +++ Q + E K + EQ+ +N Sbjct: 582 GASHEQAAAALKGA--GQTVTIIAQYQPEDYARFEAKIH--------DLREQM-----MN 626 Query: 503 DSGSAGLGVSLKGNKSR 519 S S+G G SL+ N+ R Sbjct: 627 HSMSSGSG-SLRTNQKR 642 Score = 47.8 bits (112), Expect = 6e-05 Identities = 26/67 (38%), Positives = 38/67 (56%), Gaps = 5/67 (7%) Query: 505 GSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNH 564 GS GLG ++ G + E GIF+ I+ GG A G L+ DQ+++VNG L G S+ Sbjct: 532 GSTGLGFNIVGGEDGE-----GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHE 586 Query: 565 EAMETLR 571 +A L+ Sbjct: 587 QAAAALK 593 Score = 33.1 bits (74), Expect = 1.5 Identities = 13/48 (27%), Positives = 28/48 (58%) Query: 230 GLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQA 277 G+FI I + +G N+CI+++N VD+ + + ++A + ++A Sbjct: 231 GIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEA 278 >gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] Length = 870 Score = 80.9 bits (198), Expect = 6e-15 Identities = 67/194 (34%), Positives = 96/194 (49%), Gaps = 26/194 (13%) Query: 383 KIDLKKGPEGLGFTVVTRDSSIH-GPGP-IFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440 +I L++G GLGF++ + H G P IF+ I+P GAA +DGRL+ D IL VN D Sbjct: 98 EITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVD 157 Query: 441 VTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIP 500 V+ + + V L+ G L + R+ LET EI Sbjct: 158 VSEVSHSKAVEALKEA--GSIVRLYVRRRRP----------------ILET----VVEIK 195 Query: 501 LNDSGSAGLGVSLKGNKSRE-TGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLL 559 L G GLG S+ G + D I++ II GGAA KDGRL++ D+L+ VN SL Sbjct: 196 LF-KGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLE 254 Query: 560 GKSNHEAMETLRRS 573 ++ EA+ L+ + Sbjct: 255 EVTHEEAVAILKNT 268 Score = 66.6 bits (161), Expect = 1e-10 Identities = 37/79 (46%), Positives = 51/79 (64%), Gaps = 2/79 (2%) Query: 382 IKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGDRILEVNGR 439 ++I L KGP+GLGF++ + H PG I+V I+ GAA KDGRLQ GDR+L VN Sbjct: 192 VEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNY 251 Query: 440 DVTGRTQEELVAMLRSTKQ 458 + T EE VA+L++T + Sbjct: 252 SLEEVTHEEAVAILKNTSE 270 Score = 60.1 bits (144), Expect = 1e-08 Identities = 42/119 (35%), Positives = 60/119 (50%), Gaps = 9/119 (7%) Query: 491 TSEQLTFEIPLNDSGSAGLGVSLKGNKSR-ETGTDLGIFIKSIIHGGAAFKDGRLRMNDQ 549 T + FE + G++GLG S+ G G D GIFI II GGAA +DGRLR+ND Sbjct: 90 TEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDC 149 Query: 550 LIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKP 608 ++ VN + S+ +A+E L+ + G I + +RR +E E F P Sbjct: 150 ILRVNEVDVSEVSHSKAVEALKEA--------GSIVRLYVRRRRPILETVVEIKLFKGP 200 Score = 57.4 bits (137), Expect = 7e-08 Identities = 49/137 (35%), Positives = 68/137 (49%), Gaps = 20/137 (14%) Query: 383 KIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVT 442 K+ L KG GLGF +V + G G IFV IL G A G LQ GD+IL VNG D+ Sbjct: 421 KVVLHKGSTGLGFNIVGGED---GEG-IFVSFILAGGPADLSGELQRGDQILSVNGIDLR 476 Query: 443 GRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLN 502 G + E+ A L+ G+T +++ Q + E K + EQ+ +N Sbjct: 477 GASHEQAAAALKGA--GQTVTIIAQYQPEDYARFEAKIH--------DLREQM-----MN 521 Query: 503 DSGSAGLGVSLKGNKSR 519 S S+G G SL+ N+ R Sbjct: 522 HSMSSGSG-SLRTNQKR 537 Score = 47.8 bits (112), Expect = 6e-05 Identities = 26/67 (38%), Positives = 38/67 (56%), Gaps = 5/67 (7%) Query: 505 GSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNH 564 GS GLG ++ G + E GIF+ I+ GG A G L+ DQ+++VNG L G S+ Sbjct: 427 GSTGLGFNIVGGEDGE-----GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHE 481 Query: 565 EAMETLR 571 +A L+ Sbjct: 482 QAAAALK 488 Score = 33.1 bits (74), Expect = 1.5 Identities = 13/48 (27%), Positives = 28/48 (58%) Query: 230 GLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQA 277 G+FI I + +G N+CI+++N VD+ + + ++A + ++A Sbjct: 126 GIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEA 173 >gi|18375650 protein tyrosine phosphatase, non-receptor type 13 isoform 4 [Homo sapiens] Length = 2490 Score = 80.1 bits (196), Expect = 1e-14 Identities = 63/255 (24%), Positives = 107/255 (41%), Gaps = 31/255 (12%) Query: 338 SPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTV 397 +P+ ++S+S+ + P P + N N+ I + + G+ +V Sbjct: 1336 TPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTVLFDKGGVNTSV 1395 Query: 398 VTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTK 457 G I+VK ++P+GAA DGR+ GDR+L VNG + G T ++ V LR+T Sbjct: 1396 --------RHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNT- 1446 Query: 458 QGETASLVIARQEGHFLPRELKGEPDCCALSLE--------------------TSEQLTF 497 G+ L++ + + + P C +E+ TF Sbjct: 1447 -GQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTF 1505 Query: 498 EIPL-NDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGE 556 E+ L +S G S + N E + +K + G A + G++ + D ++ VNG Sbjct: 1506 EVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGA 1565 Query: 557 SLLGKSNHEAMETLR 571 SL G S E + LR Sbjct: 1566 SLKGLSQQEVISALR 1580 Score = 57.4 bits (137), Expect = 7e-08 Identities = 66/315 (20%), Positives = 118/315 (37%), Gaps = 71/315 (22%) Query: 204 VEISGEGGPLGIHVVPFFS----SLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINN 259 VE++ LGI V F + S R G++++ + ++ +G H+ + ++ +N Sbjct: 1369 VELAKNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNG 1428 Query: 260 VDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVP 319 V L T QA + R + ++H+L + + K + Sbjct: 1429 VSLEGATHKQAVETLRNTGQ----VVHLLLEKGQSPTSKEHV------------------ 1466 Query: 320 PPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNA 379 PV + L N G + + ++ F + +N Sbjct: 1467 -PVTPQCTLSDQNAQGQGPEKVKKTTQVKD---------------------YSFVTEENT 1504 Query: 380 KKIKIDLKKGPEGLGFTVVTRDSSIH---GPGPIFVKNILPKGAAIKDGRLQSGDRILEV 436 ++K L K GLGF+ D+ I + VK + P A + G++ GD IL+V Sbjct: 1505 FEVK--LFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKV 1562 Query: 437 NGRDVTGRTQEELVAMLRST----------------KQGETASLVIARQEGHFLPRELK- 479 NG + G +Q+E+++ LR T + +TA L + LP K Sbjct: 1563 NGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKD 1622 Query: 480 -GEPDCCALSLETSE 493 +P C S + E Sbjct: 1623 SSQPSCVEQSTSSDE 1637 Score = 52.4 bits (124), Expect = 2e-06 Identities = 90/424 (21%), Positives = 159/424 (37%), Gaps = 72/424 (16%) Query: 174 LEDREVLNGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRI-LGLF 232 L++ +VL+ + +++SP + TL ++ + + LG ++ GR+ LG+F Sbjct: 1071 LKENDVLHK-RWSIVSSPEREITLVNLKKDAKYG-----LGFQIIG--GEKMGRLDLGIF 1122 Query: 233 IRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQA--------------- 277 I + + +G + ++ +N+V L + A ++ + A Sbjct: 1123 ISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKI 1182 Query: 278 MKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNND------GVLKTKVPPPVHGKSGLKTA 331 K PS +H+ + S + I ++ G L+ GL+ Sbjct: 1183 SKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREG 1242 Query: 332 NLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSL--SPLMGFGSNKNAKKIKIDLKKG 389 +L+ DS AS S Q LG + S SP S K+ D Sbjct: 1243 SLSSQDSRTESASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFTD---- 1298 Query: 390 PEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEEL 449 + S PG V + +G + D S + +D QE Sbjct: 1299 ---------SNQSKTKKPGISDVTDYSDRGDSDMDEATYS-------SSQDHQTPKQESS 1342 Query: 450 VAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSGSAGL 509 ++ S K + G EL + +S+ L D G G+ Sbjct: 1343 SSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTV---------LFDKG--GV 1391 Query: 510 GVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMET 569 S++ GI++K++I GAA DGR+ D+++AVNG SL G ++ +A+ET Sbjct: 1392 NTSVRHG---------GIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVET 1442 Query: 570 LRRS 573 LR + Sbjct: 1443 LRNT 1446 Score = 49.7 bits (117), Expect = 2e-05 Identities = 73/286 (25%), Positives = 113/286 (39%), Gaps = 37/286 (12%) Query: 381 KIKIDLKKGPEG-LGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGR 439 ++ I L K +G LGFTV + I +V +++ + A DGRL+ GDR+++VN Sbjct: 1791 ELLITLIKSEKGSLGFTVTKGNQRIG----CYVHDVI-QDPAKSDGRLKPGDRLIKVNDT 1845 Query: 440 DVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEI 499 DVT T + V +LR+ +T LVI R LPR + L +I Sbjct: 1846 DVTNMTHTDAVNLLRAA--SKTVRLVIGRVLE--LPR------------IPMLPHLLPDI 1889 Query: 500 PLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLL 559 L LG SL G ++I I A +G L++ D + VNG S Sbjct: 1890 TLT-CNKEELGFSLCGGHDSLYQV---VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQ 1945 Query: 560 GKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAE---------CGAFSKPCF 610 G + E L S+ L ++ +R + G+ S+P Sbjct: 1946 GMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPAL 2005 Query: 611 ENCQNAVTTSRRNDNSILHPLGTCSPQD--KQKGLLLPNDGWAESE 654 + T + N I +P G CS L LP + + + + Sbjct: 2006 TPNDSFSTVAGEEINEISYPKGKCSTYQIKGSPNLTLPKESYIQED 2051 Score = 34.7 bits (78), Expect = 0.51 Identities = 29/107 (27%), Positives = 49/107 (45%), Gaps = 12/107 (11%) Query: 490 ETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQ 549 E +L + ++ GS G V+ KGN+ +G ++ +I A DGRL+ D+ Sbjct: 1787 ELEVELLITLIKSEKGSLGFTVT-KGNQR------IGCYVHDVIQDPAK-SDGRLKPGDR 1838 Query: 550 LIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPM 596 LI VN + ++ +A+ LR + + G +L P PM Sbjct: 1839 LIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR----VLELPRIPM 1881 Score = 33.1 bits (74), Expect = 1.5 Identities = 35/122 (28%), Positives = 53/122 (43%), Gaps = 22/122 (18%) Query: 332 NLTGTDSPETDASAS----LQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLK 387 N+T TD+ +AS L + +PR+ P P L P + NK Sbjct: 1849 NMTHTDAVNLLRAASKTVRLVIGRVLELPRI---PMLPHLLPDITLTCNK---------- 1895 Query: 388 KGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQE 447 E LGF++ S++ +++ +I P+ A +G LQ D I VNG G T E Sbjct: 1896 ---EELGFSLCGGHDSLYQV--VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLE 1950 Query: 448 EL 449 E+ Sbjct: 1951 EV 1952 >gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens] Length = 728 Score = 79.7 bits (195), Expect = 1e-14 Identities = 77/276 (27%), Positives = 129/276 (46%), Gaps = 48/276 (17%) Query: 349 QNKSPRVPRLGGKPSSPSLSPLMGFGSNK--------NAKKIKIDLKKGP-EGLGFTVVT 399 + +SP + + G S+ S SP G SN + ++++K P E LG TV Sbjct: 465 RQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAG 524 Query: 400 RDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQG 459 S PI+V ++ P G +DGR+++GD +L V+G ++T ++ E VA+L+ T Sbjct: 525 GASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRT--- 581 Query: 460 ETASLVIARQEGHFLPRELKGEPDCCA-LSLETSEQLT------------FEIP------ 500 ++S+V+ E +E + + DC + +L+++ + E+P Sbjct: 582 -SSSIVLKALE----VKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNC 636 Query: 501 ----LNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGE 556 L + + LG + G G + FIKSI+ G A+ DGR+R D L+AVNG Sbjct: 637 KDIVLRRNTAGSLGFCIVGGYEEYNG-NKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGR 695 Query: 557 SLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRP 592 S G H + L + ++G I L I+ P Sbjct: 696 STSGMI-HACLARLLK------ELKGRITLTIVSWP 724 Score = 62.8 bits (151), Expect = 2e-09 Identities = 60/226 (26%), Positives = 95/226 (42%), Gaps = 24/226 (10%) Query: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469 I +++I G +DGRL GD IL+VNG D++ V +LR Q L + R+ Sbjct: 301 IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQ--VLWLTVMRE 358 Query: 470 EGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSG-SAGLGVSLKGNKSRETGTDLGIF 528 + F R PD +F + LN S LG+ L G+F Sbjct: 359 Q-KFRSRNNGQAPDAYR-----PRDDSFHVILNKSSPEEQLGIKLVRKVDEP-----GVF 407 Query: 529 IKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVI 588 I +++ GG A++ G+L ND+++A+NG L S A ++ S + LV+ Sbjct: 408 IFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQAS-------ERRVHLVV 460 Query: 589 LRRPERPMEDPAECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTC 634 R+ + D + ++ + R N LHP TC Sbjct: 461 SRQVRQRSPDIFQEAGWNS---NGSWSPGPGERSNTPKPLHPTITC 503 >gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens] Length = 632 Score = 79.7 bits (195), Expect = 1e-14 Identities = 77/276 (27%), Positives = 129/276 (46%), Gaps = 48/276 (17%) Query: 349 QNKSPRVPRLGGKPSSPSLSPLMGFGSNK--------NAKKIKIDLKKGP-EGLGFTVVT 399 + +SP + + G S+ S SP G SN + ++++K P E LG TV Sbjct: 369 RQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAG 428 Query: 400 RDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQG 459 S PI+V ++ P G +DGR+++GD +L V+G ++T ++ E VA+L+ T Sbjct: 429 GASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRT--- 485 Query: 460 ETASLVIARQEGHFLPRELKGEPDCCA-LSLETSEQLT------------FEIP------ 500 ++S+V+ E +E + + DC + +L+++ + E+P Sbjct: 486 -SSSIVLKALE----VKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNC 540 Query: 501 ----LNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGE 556 L + + LG + G G + FIKSI+ G A+ DGR+R D L+AVNG Sbjct: 541 KDIVLRRNTAGSLGFCIVGGYEEYNG-NKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGR 599 Query: 557 SLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRP 592 S G H + L + ++G I L I+ P Sbjct: 600 STSGMI-HACLARLLK------ELKGRITLTIVSWP 628 Score = 62.8 bits (151), Expect = 2e-09 Identities = 60/226 (26%), Positives = 95/226 (42%), Gaps = 24/226 (10%) Query: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469 I +++I G +DGRL GD IL+VNG D++ V +LR Q L + R+ Sbjct: 205 IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQ--VLWLTVMRE 262 Query: 470 EGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSG-SAGLGVSLKGNKSRETGTDLGIF 528 + F R PD +F + LN S LG+ L G+F Sbjct: 263 Q-KFRSRNNGQAPDAYR-----PRDDSFHVILNKSSPEEQLGIKLVRKVDEP-----GVF 311 Query: 529 IKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVI 588 I +++ GG A++ G+L ND+++A+NG L S A ++ S + LV+ Sbjct: 312 IFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQAS-------ERRVHLVV 364 Query: 589 LRRPERPMEDPAECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTC 634 R+ + D + ++ + R N LHP TC Sbjct: 365 SRQVRQRSPDIFQEAGWNS---NGSWSPGPGERSNTPKPLHPTITC 407 >gi|87196343 PDZ domain containing 2 [Homo sapiens] Length = 2839 Score = 74.7 bits (182), Expect = 4e-13 Identities = 56/198 (28%), Positives = 96/198 (48%), Gaps = 16/198 (8%) Query: 387 KKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQ 446 +K GLGF+V + P I V + +GAA ++G + GD +L VNG + G Sbjct: 2627 RKEGSGLGFSVA--GGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAH 2684 Query: 447 EELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFE------IP 500 ++ +L + + A +VI + P + P L + + + E + Sbjct: 2685 GNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRSVA 2744 Query: 501 LNDS-------GSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAV 553 ++D+ SAGLG+SL G KS TG D + IK + GGAA + G + D+++A+ Sbjct: 2745 VHDALCVEVLKTSAGLGLSLDGGKSSVTG-DGPLVIKRVYKGGAAEQAGIIEAGDEILAI 2803 Query: 554 NGESLLGKSNHEAMETLR 571 NG+ L+G + +A ++ Sbjct: 2804 NGKPLVGLMHFDAWNIMK 2821 Score = 68.9 bits (167), Expect = 2e-11 Identities = 115/489 (23%), Positives = 190/489 (38%), Gaps = 93/489 (19%) Query: 387 KKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQ 446 K+ +GLGF++ I G IFVK I P G+A +DGRL+ GD IL+VNG + G T Sbjct: 591 KEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTF 650 Query: 447 EELVAMLRSTKQGETASLVIARQEGHFL-----PREL------------------KGEPD 483 +E + + + G V + L P + E Sbjct: 651 QEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGS 710 Query: 484 CCALSLET---SEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFK 540 +L +T +++ E+ LN GLG+ + GI+I S+ G A Sbjct: 711 SSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPP--GIYIHSLAPGSVAKM 768 Query: 541 DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA 600 + L DQ++ VN ++ H A+ + +S G ++LVI R P + + Sbjct: 769 ESNLSRGDQILEVNSVNV----RHAALSKVHAILSK--CPPGPVRLVIGRHPNPKVSEQE 822 Query: 601 ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGT--CSPQDKQKGLLLPNDGWAESEVPPS 658 ++ ++ + A ++ LGT SP +K L+ ++ Sbjct: 823 MDEVIARSTYQESKEANSSP---------GLGTPLKSPSLAKKDSLISESELSQYFAHDV 873 Query: 659 PTPHS-ALGLGLEDYSH-SSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPD 716 P P S + G ED H SG ++ E +L S S P Sbjct: 874 PGPLSDFMVAGSEDEDHPGSGCSTS-------------------EEGSLPPSTSTHKEPG 914 Query: 717 ESKVHSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPF--HRPRPHMVRG 774 + + +SL TLG ++S L Q VA R+ LP R ++R Sbjct: 915 KPRANSLV-------------TLGSHRASGLFHKQVTVA--RQASLPGSPQALRNPLLRQ 959 Query: 775 R--GCNESFRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQ----GNSELEDME 828 R GC ++ A+ ++ +D E D +S + G E P+ +S+ D+ Sbjct: 960 RKVGCYDANDASDEEEFDR----EGDCISLPGALPGPIRPLSEDDPRRVSISSSKGMDVH 1015 Query: 829 NKARKVKKT 837 N+ + +KT Sbjct: 1016 NQEERPRKT 1024 Score = 57.4 bits (137), Expect = 7e-08 Identities = 47/133 (35%), Positives = 65/133 (48%), Gaps = 9/133 (6%) Query: 339 PETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKI-KIDLKKGPEGLGFTV 397 P+TDA + +K R GGK S L + + +I K++L K +GLG V Sbjct: 295 PKTDAPLTTSNDK--RRFSKGGKTDFQSSDCL----AREEVGRIWKMELLKESDGLGIQV 348 Query: 398 VTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTK 457 S P I V + GAA +DGRL GD +L +NG + G + EE VA+LRS Sbjct: 349 SGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSAT 408 Query: 458 QGETASLVIARQE 470 LV+A +E Sbjct: 409 --GMVQLVVASKE 419 Score = 56.6 bits (135), Expect = 1e-07 Identities = 37/120 (30%), Positives = 61/120 (50%), Gaps = 9/120 (7%) Query: 506 SAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHE 565 S GLG+ + G + + I + + GGAA +DGRL + D+L+ +NG L+G S+ E Sbjct: 341 SDGLGIQVSGGRGSKRSPH-AIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEE 399 Query: 566 AMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKPCFENCQNAVTTSRRNDN 625 A+ LR + GM+QLV+ + E ED + S P + V++ N++ Sbjct: 400 AVAILR-------SATGMVQLVVASK-ENSAEDLLRLTSKSLPDLTSSVEDVSSWTDNED 451 Score = 50.4 bits (119), Expect = 9e-06 Identities = 24/82 (29%), Positives = 46/82 (56%) Query: 384 IDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTG 443 +++ K GLG ++ SS+ G GP+ +K + GAA + G +++GD IL +NG+ + G Sbjct: 2751 VEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVG 2810 Query: 444 RTQEELVAMLRSTKQGETASLV 465 + +++S +G L+ Sbjct: 2811 LMHFDAWNIMKSVPEGPVQLLI 2832 Score = 50.1 bits (118), Expect = 1e-05 Identities = 71/311 (22%), Positives = 120/311 (38%), Gaps = 59/311 (18%) Query: 209 EGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFA 268 +G LG + + G+ +G+F++ I N + +G E + I+ +N + + TF Sbjct: 593 KGKGLGFSIAGGRDCIRGQ-MGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQ 651 Query: 269 QAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGL 328 +A F+Q VL ++TK+ P Sbjct: 652 EAIHTFKQIRSGLFVL----------------------------TVRTKLVSPSLTPCST 683 Query: 329 KTANLTGTDSPE--TDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDL 386 T +++ + SP T AS + LG K P K+ +++ L Sbjct: 684 PT-HMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPGP-----------KDRIVMEVTL 731 Query: 387 KKGPE---GLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTG 443 K P G+G + ++S P I++ ++ P A + L GD+ILEVN +V Sbjct: 732 NKEPRVGLGIGACCLALENS---PPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRH 788 Query: 444 RTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLND 503 ++ A+L G LVI R H P+ + E D E + T++ Sbjct: 789 AALSKVHAILSKCPPG-PVRLVIGR---HPNPKVSEQEMD------EVIARSTYQESKEA 838 Query: 504 SGSAGLGVSLK 514 + S GLG LK Sbjct: 839 NSSPGLGTPLK 849 Score = 41.2 bits (95), Expect = 0.005 Identities = 33/117 (28%), Positives = 55/117 (47%), Gaps = 10/117 (8%) Query: 490 ETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDL---GIFIKSIIHGGAAFKDGRLRM 546 E E + F I LN +GLG S+ G GTD+ I + + GAA ++G + Sbjct: 2615 ENEEDVCF-IVLNRKEGSGLGFSVAG------GTDVEPKSITVHRVFSQGAASQEGTMNR 2667 Query: 547 NDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECG 603 D L++VNG SL G ++ ++ L ++ + + + + + RP E P G Sbjct: 2668 GDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANG 2724 Score = 33.1 bits (74), Expect = 1.5 Identities = 23/87 (26%), Positives = 44/87 (50%), Gaps = 10/87 (11%) Query: 510 GVSLKGNKSRETGT----DLG-IFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNH 564 G +G K R+T D+G I++ + A K G++R+ D+++++NG+ ++G Sbjct: 97 GEKRRGGKKRKTHQGPVLDVGCIWVTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVS 156 Query: 565 EAMETLRRSMSMEGNIRGMIQLVILRR 591 A + + G I L++LRR Sbjct: 157 GASYLAEQCWN-----GGFIYLIMLRR 178 >gi|218505835 membrane-associated guanylate kinase-related 3 isoform 1 [Homo sapiens] Length = 1481 Score = 72.8 bits (177), Expect = 2e-12 Identities = 146/697 (20%), Positives = 256/697 (36%), Gaps = 159/697 (22%) Query: 335 GTDSPETDASASL--QQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEG 392 G PE D+S + QN SPR+ R P+ P+ + + + K+ EG Sbjct: 813 GEKQPEDDSSQAFISTQNGSPRLNR-AEVPARPA---------PQEPYDVVLQRKEN-EG 861 Query: 393 LGFTVVT-RDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVA 451 GF ++T ++ G P + ++ A + G+L+ GD I VNG+ + + + +V Sbjct: 862 FGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQ 921 Query: 452 MLRSTKQGETASLVIARQEGHFLPRE------------------------------LKGE 481 +++ G T +L + +E H P L+GE Sbjct: 922 LIKDA--GVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGE 979 Query: 482 ---------------------PDCCALSLETSEQLT----FEIPLNDSGSAGLGVSLKGN 516 PD +S+ S + + L + G G G SL+G Sbjct: 980 IGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVEL-ERGPRGFGFSLRGG 1038 Query: 517 KSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSM 576 K ++G+FI + G A KDGR+ + DQ++ +NGE G ++ A+E ++ + Sbjct: 1039 KEY----NMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNK 1094 Query: 577 ----------------EGNIRGMIQLVILRRPERPMEDPAECGAFSK----PCFENCQNA 616 + +I ++ + P+ + + + P E Sbjct: 1095 VLLLLRPGTGLIPDHGDWDINNPSSSNVIYDEQSPLPPSSHFASIFEESHVPVIEESLRV 1154 Query: 617 VTTSRRNDNSILHP-----LGTCSPQDKQKGLLLPNDGWAESEVPPSPTPHSALGLGLED 671 + + + P L P+ K + LL N PPS HS + Sbjct: 1155 QICEKAEELKDIVPEKKSTLNENQPEIKHQSLLQKN---VSKRDPPSSHGHS-------N 1204 Query: 672 YSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKVHSLAGQKSESP 731 + V++ V RSV+P ++P S + + + +D +P K + + +S Sbjct: 1205 KKNLLKVENGV-----TRRGRSVSP-KKPASQH--SEEHLDKIPSPLKNNPKRRPRDQSL 1256 Query: 732 SKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNESFRAAIDKSYDG 791 S G + S+ S Q + RK+ RGR + + I+ S Sbjct: 1257 SPSKGENKSCQVSTRAGSGQD---QCRKS------------RGRSASPKKQQKIEGS-KA 1300 Query: 792 PEEIEADGLSDKSSH-SGQGALNCESAPQGNSELEDMENKARKVKKTKEKEKKKEKGKLK 850 P EA L KS +G N E P G + + + A++ + K + + EK + Sbjct: 1301 PSNAEAKLLEGKSRRIAGYTGSNAEQIPDGKEKSDVIRKDAKQNQLEKSRTRSPEKKIKR 1360 Query: 851 VKEK------------KRKEENE--------DPERKIKKKGFGAMLRFGKKKEDKGGKAE 890 + EK K ENE + K G L + K++ K Sbjct: 1361 MVEKSLPSKMTNKTTSKEVSENEKGKKVTTGETSSSNDKIGENVQLSEKRLKQEPEEKVV 1420 Query: 891 QKGTLKHGGLREEELEKMKEERESGRPTGGSTDRIQK 927 T H G +ELE + +E+GR S+ ++K Sbjct: 1421 SNKTEDHKG---KELEAADKNKETGRFKPESSSPVKK 1454 Score = 69.3 bits (168), Expect = 2e-11 Identities = 67/273 (24%), Positives = 125/273 (45%), Gaps = 34/273 (12%) Query: 326 SGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPS-----SPSLSPLMGFGSNK--- 377 S KTA + TD E + SL+ P + PS SP L P + +K Sbjct: 659 SPTKTAKMK-TDKKEN--AGSLEAINEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLY 715 Query: 378 -----NAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGP-IFVKNILPKGAAIKDGRLQSGD 431 N K + + L+K G GF V+ D GP I++ I+P GAA KDGRL++ D Sbjct: 716 EDKPPNTKDLDVFLRKQESGFGFRVLGGD----GPDQSIYIGAIIPLGAAEKDGRLRAAD 771 Query: 432 RILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ--EGHFLPRE---------LKG 480 ++ ++G V G++ ++++ ++ + + L + R+ G P + G Sbjct: 772 ELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNG 831 Query: 481 EP--DCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAA 538 P + + + Q +++ L + G G + +K++ + I +I G A Sbjct: 832 SPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPA 891 Query: 539 FKDGRLRMNDQLIAVNGESLLGKSNHEAMETLR 571 + G+L++ D + AVNG+S++ S+ ++ ++ Sbjct: 892 DRCGKLKVGDHISAVNGQSIVELSHDNIVQLIK 924 Score = 53.9 bits (128), Expect = 8e-07 Identities = 31/94 (32%), Positives = 50/94 (53%), Gaps = 5/94 (5%) Query: 382 IKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDV 441 ++ LKK G GFT++ D + VKN+L G A +DG++ GD I+++NG V Sbjct: 409 VRASLKKSTMGFGFTIIGGDRPDEF---LQVKNVLKDGPAAQDGKIAPGDVIVDINGNCV 465 Query: 442 TGRTQEELVAMLRSTKQGETASLVIARQEGHFLP 475 G T ++V M + + +L + R G+ LP Sbjct: 466 LGHTHADVVQMFQLVPVNQYVNLTLCR--GYPLP 497 Score = 53.5 bits (127), Expect = 1e-06 Identities = 75/322 (23%), Positives = 123/322 (38%), Gaps = 50/322 (15%) Query: 320 PPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRV---PRLGGKPSSPSLSPLMGFGSN 376 P ++G+S K + A Q KS L G + M + Sbjct: 512 PVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGS 571 Query: 377 KNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEV 436 + + I L KGP+G GF + P VK IL LQ GD I E+ Sbjct: 572 SQPELVTIPLIKGPKGFGFAIAD------SPTGQKVKMILDSQWC---QGLQKGDIIKEI 622 Query: 437 NGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPD-------CCALSL 489 ++V T ++V +L+ G L+I R + K + D A++ Sbjct: 623 YHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINE 682 Query: 490 ETSEQLTFEIPLNDSGSAGLGVSLKGNKSRET---------------------------- 521 + + F + SGS L S KS+ Sbjct: 683 PIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLG 742 Query: 522 --GTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGN 579 G D I+I +II GAA KDGRLR D+L+ ++G + GKS+ + ++ L + + G+ Sbjct: 743 GDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLD-LMTTAARNGH 801 Query: 580 IRGMIQLVILRRPERPMEDPAE 601 + ++ I ++P +D ++ Sbjct: 802 VLLTVRRKIFYGEKQPEDDSSQ 823 Score = 31.2 bits (69), Expect = 5.7 Identities = 10/40 (25%), Positives = 26/40 (65%) Query: 529 IKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAME 568 +K+++ G A +DG++ D ++ +NG +LG ++ + ++ Sbjct: 436 VKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQ 475 >gi|27262655 interleukin 16 isoform 1 precursor [Homo sapiens] Length = 631 Score = 71.2 bits (173), Expect = 5e-12 Identities = 51/198 (25%), Positives = 94/198 (47%), Gaps = 15/198 (7%) Query: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469 I V + P G A ++G +Q G+ +L +NG+ + G T + +A+LR ++ A +V + Sbjct: 438 ITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKL 497 Query: 470 EGHFLPRELKGEPDCCA-------LSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETG 522 +P +L D A +S+E++ + T + SAGLG SL+G K G Sbjct: 498 TPEAMP-DLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHG 556 Query: 523 TDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRG 582 D + I I G A+ + ++ D+++ + G ++ G + EA ++ G Sbjct: 557 -DKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPD------G 609 Query: 583 MIQLVILRRPERPMEDPA 600 + +VI R+ + E A Sbjct: 610 PVTIVIRRKSLQSKETTA 627 Score = 46.2 bits (108), Expect = 2e-04 Identities = 36/144 (25%), Positives = 63/144 (43%), Gaps = 17/144 (11%) Query: 342 DASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG----------------SNKNAKKIKID 385 DA A L+Q + PR + + +P P + S A + Sbjct: 476 DALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVT 535 Query: 386 LKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRT 445 L+K GLGF++ S+HG P+ + I A+ + +Q GD IL++ G + G T Sbjct: 536 LEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLT 595 Query: 446 QEELVAMLRSTKQGETASLVIARQ 469 + E ++++ G ++VI R+ Sbjct: 596 RFEAWNIIKALPDG-PVTIVIRRK 618 >gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo sapiens] Length = 1287 Score = 70.9 bits (172), Expect = 6e-12 Identities = 93/379 (24%), Positives = 152/379 (40%), Gaps = 64/379 (16%) Query: 230 GLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLP 289 G+FI I +++ I+ +N++ L TF A R SP Sbjct: 780 GIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMA---VRMIQNSP-------- 828 Query: 290 PQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQ 349 + E + S + GNN K SG+ + ++ + S + Q Sbjct: 829 ----DNIELIISQSKGVGGNNPDEEKNST-----ANSGVSSTDILSFGYQGSLLSHTQDQ 879 Query: 350 NKSPRVPRLGGKPS-------SPSLSPLMGFGSNKNAKKIKI--------DLKKGPEGLG 394 +++ + G S S PL G GS+ +I +L K LG Sbjct: 880 DRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTLG 939 Query: 395 FTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLR 454 F+V ++ G I+VK+I+P G A K+G++ GDR+L+V+G + G T ++ V L Sbjct: 940 FSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCL- 998 Query: 455 STKQGETASLVIAR-------------------QEGHFLPRELKGEPDCCALSLETSEQL 495 T G+ A LV+ R + L L G P C + ++ Sbjct: 999 -TGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSC---VSVTDGP 1054 Query: 496 TFEIPLNDSGSAGLG---VSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIA 552 FE+ L + + GLG V ++ +DL + IK + G A ++G + D ++A Sbjct: 1055 KFEVKLKKNAN-GLGFSFVQMEKESCSHLKSDL-VRIKRLFPGQPAEENGAIAAGDIILA 1112 Query: 553 VNGESLLGKSNHEAMETLR 571 VNG S G E + LR Sbjct: 1113 VNGRSTEGLIFQEVLHLLR 1131 Score = 54.3 bits (129), Expect = 6e-07 Identities = 82/334 (24%), Positives = 132/334 (39%), Gaps = 71/334 (21%) Query: 204 VEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLV 263 VE+ E G LG V ++ S G++++ I + +EG + + +++++ V L Sbjct: 929 VELVKEDGTLGFSVTGGINT-SVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILC 987 Query: 264 DKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVH 323 T QA Q + P + + VL+ +VP Sbjct: 988 GLTHKQAV----QCLTGPGQVARL-------------------------VLERRVPRSTQ 1018 Query: 324 GKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIK 383 P + S ++ V L G+PSS S + K + Sbjct: 1019 -------------QCPSANDSMGDERTAVSLVTALPGRPSSCV--------SVTDGPKFE 1057 Query: 384 IDLKKGPEGLGFTVVT--RDSSIHGPGPIF-VKNILPKGAAIKDGRLQSGDRILEVNGRD 440 + LKK GLGF+ V ++S H + +K + P A ++G + +GD IL VNGR Sbjct: 1058 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 1117 Query: 441 VTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLE---------- 490 G +E++ +LR Q T L++ R LP EL+ E LS + Sbjct: 1118 TEGLIFQEVLHLLRGAPQEVT--LLLCRPPPGALP-ELEQEWQTPELSADKEFTRATCTD 1174 Query: 491 --TSEQLTFEIPLNDSGS--AGLGVSLKGNKSRE 520 TS L E DS S AG G+ L+ S++ Sbjct: 1175 SCTSPILDQEDSWRDSASPDAGEGLGLRPESSQK 1208 Score = 40.8 bits (94), Expect = 0.007 Identities = 30/112 (26%), Positives = 54/112 (48%), Gaps = 13/112 (11%) Query: 371 MGFGSNKNAKK----------IKIDLKKGPE-GLGFTVVTRDSSIHGPGPIFVKNILPKG 419 M GS N +K +++ LK+ P G GF + + S IF+ +I+P G Sbjct: 731 MHAGSKNNRRKSFIAEPGREIVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGG 790 Query: 420 AAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEG 471 A K ++ G +IL +N + G T V M++++ + L+I++ +G Sbjct: 791 PAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSP--DNIELIISQSKG 840 Score = 37.7 bits (86), Expect = 0.060 Identities = 52/188 (27%), Positives = 81/188 (43%), Gaps = 18/188 (9%) Query: 524 DLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGM 583 D GIFI SII GG A K ++ Q++A+N SL G + + A+ ++ S I Sbjct: 778 DPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELIISQ 837 Query: 584 IQLVILRRPERPMEDPAECGAFSKPC----FENCQNAVTTSRRNDNSILHPLGTCS--PQ 637 + V P+ A G S ++ + T + + L G S P+ Sbjct: 838 SKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSHTQDQDRNTEELDMAGVQSLVPR 897 Query: 638 DKQKGLLLPNDGWAESEVPPSPTPHSA-----LGLGLED----YSHSSGVDSAVYFPDQH 688 + + LP G A S PPSP SA + L ED +S + G++++V P Sbjct: 898 LRHQLSFLPLKG-AGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSV--PYGG 954 Query: 689 INFRSVTP 696 I +S+ P Sbjct: 955 IYVKSIVP 962 >gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo sapiens] Length = 1309 Score = 70.9 bits (172), Expect = 6e-12 Identities = 93/379 (24%), Positives = 152/379 (40%), Gaps = 64/379 (16%) Query: 230 GLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLP 289 G+FI I +++ I+ +N++ L TF A R SP Sbjct: 802 GIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMA---VRMIQNSP-------- 850 Query: 290 PQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQ 349 + E + S + GNN K SG+ + ++ + S + Q Sbjct: 851 ----DNIELIISQSKGVGGNNPDEEKNST-----ANSGVSSTDILSFGYQGSLLSHTQDQ 901 Query: 350 NKSPRVPRLGGKPS-------SPSLSPLMGFGSNKNAKKIKI--------DLKKGPEGLG 394 +++ + G S S PL G GS+ +I +L K LG Sbjct: 902 DRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTLG 961 Query: 395 FTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLR 454 F+V ++ G I+VK+I+P G A K+G++ GDR+L+V+G + G T ++ V L Sbjct: 962 FSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCL- 1020 Query: 455 STKQGETASLVIAR-------------------QEGHFLPRELKGEPDCCALSLETSEQL 495 T G+ A LV+ R + L L G P C + ++ Sbjct: 1021 -TGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSC---VSVTDGP 1076 Query: 496 TFEIPLNDSGSAGLG---VSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIA 552 FE+ L + + GLG V ++ +DL + IK + G A ++G + D ++A Sbjct: 1077 KFEVKLKKNAN-GLGFSFVQMEKESCSHLKSDL-VRIKRLFPGQPAEENGAIAAGDIILA 1134 Query: 553 VNGESLLGKSNHEAMETLR 571 VNG S G E + LR Sbjct: 1135 VNGRSTEGLIFQEVLHLLR 1153 Score = 54.3 bits (129), Expect = 6e-07 Identities = 82/334 (24%), Positives = 132/334 (39%), Gaps = 71/334 (21%) Query: 204 VEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLV 263 VE+ E G LG V ++ S G++++ I + +EG + + +++++ V L Sbjct: 951 VELVKEDGTLGFSVTGGINT-SVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILC 1009 Query: 264 DKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVH 323 T QA Q + P + + VL+ +VP Sbjct: 1010 GLTHKQAV----QCLTGPGQVARL-------------------------VLERRVPRSTQ 1040 Query: 324 GKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIK 383 P + S ++ V L G+PSS S + K + Sbjct: 1041 -------------QCPSANDSMGDERTAVSLVTALPGRPSSCV--------SVTDGPKFE 1079 Query: 384 IDLKKGPEGLGFTVVT--RDSSIHGPGPIF-VKNILPKGAAIKDGRLQSGDRILEVNGRD 440 + LKK GLGF+ V ++S H + +K + P A ++G + +GD IL VNGR Sbjct: 1080 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 1139 Query: 441 VTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLE---------- 490 G +E++ +LR Q T L++ R LP EL+ E LS + Sbjct: 1140 TEGLIFQEVLHLLRGAPQEVT--LLLCRPPPGALP-ELEQEWQTPELSADKEFTRATCTD 1196 Query: 491 --TSEQLTFEIPLNDSGS--AGLGVSLKGNKSRE 520 TS L E DS S AG G+ L+ S++ Sbjct: 1197 SCTSPILDQEDSWRDSASPDAGEGLGLRPESSQK 1230 Score = 40.8 bits (94), Expect = 0.007 Identities = 30/112 (26%), Positives = 54/112 (48%), Gaps = 13/112 (11%) Query: 371 MGFGSNKNAKK----------IKIDLKKGPE-GLGFTVVTRDSSIHGPGPIFVKNILPKG 419 M GS N +K +++ LK+ P G GF + + S IF+ +I+P G Sbjct: 753 MHAGSKNNRRKSFIAEPGREIVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGG 812 Query: 420 AAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEG 471 A K ++ G +IL +N + G T V M++++ + L+I++ +G Sbjct: 813 PAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSP--DNIELIISQSKG 862 Score = 37.7 bits (86), Expect = 0.060 Identities = 52/188 (27%), Positives = 81/188 (43%), Gaps = 18/188 (9%) Query: 524 DLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGM 583 D GIFI SII GG A K ++ Q++A+N SL G + + A+ ++ S I Sbjct: 800 DPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELIISQ 859 Query: 584 IQLVILRRPERPMEDPAECGAFSKPC----FENCQNAVTTSRRNDNSILHPLGTCS--PQ 637 + V P+ A G S ++ + T + + L G S P+ Sbjct: 860 SKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSHTQDQDRNTEELDMAGVQSLVPR 919 Query: 638 DKQKGLLLPNDGWAESEVPPSPTPHSA-----LGLGLED----YSHSSGVDSAVYFPDQH 688 + + LP G A S PPSP SA + L ED +S + G++++V P Sbjct: 920 LRHQLSFLPLKG-AGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSV--PYGG 976 Query: 689 INFRSVTP 696 I +S+ P Sbjct: 977 IYVKSIVP 984 >gi|155969695 membrane-associated guanylate kinase-related 3 isoform 2 [Homo sapiens] Length = 1125 Score = 69.3 bits (168), Expect = 2e-11 Identities = 67/273 (24%), Positives = 125/273 (45%), Gaps = 34/273 (12%) Query: 326 SGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPS-----SPSLSPLMGFGSNK--- 377 S KTA + TD E + SL+ P + PS SP L P + +K Sbjct: 659 SPTKTAKMK-TDKKEN--AGSLEAINEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLY 715 Query: 378 -----NAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGP-IFVKNILPKGAAIKDGRLQSGD 431 N K + + L+K G GF V+ D GP I++ I+P GAA KDGRL++ D Sbjct: 716 EDKPPNTKDLDVFLRKQESGFGFRVLGGD----GPDQSIYIGAIIPLGAAEKDGRLRAAD 771 Query: 432 RILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ--EGHFLPRE---------LKG 480 ++ ++G V G++ ++++ ++ + + L + R+ G P + G Sbjct: 772 ELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNG 831 Query: 481 EP--DCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAA 538 P + + + Q +++ L + G G + +K++ + I +I G A Sbjct: 832 SPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPA 891 Query: 539 FKDGRLRMNDQLIAVNGESLLGKSNHEAMETLR 571 + G+L++ D + AVNG+S++ S+ ++ ++ Sbjct: 892 DRCGKLKVGDHISAVNGQSIVELSHDNIVQLIK 924 Score = 64.7 bits (156), Expect = 5e-10 Identities = 69/295 (23%), Positives = 120/295 (40%), Gaps = 76/295 (25%) Query: 335 GTDSPETDASASL--QQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEG 392 G PE D+S + QN SPR+ R P+ P+ + + + K+ EG Sbjct: 813 GEKQPEDDSSQAFISTQNGSPRLNR-AEVPARPA---------PQEPYDVVLQRKEN-EG 861 Query: 393 LGFTVVT-RDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVA 451 GF ++T ++ G P + ++ A + G+L+ GD I VNG+ + + + +V Sbjct: 862 FGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQ 921 Query: 452 MLRSTKQGETASLVIARQEGHFLPRE------------------------------LKGE 481 +++ G T +L + +E H P L+GE Sbjct: 922 LIKDA--GVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGE 979 Query: 482 ---------------------PDCCALSLETSEQLT----FEIPLNDSGSAGLGVSLKGN 516 PD +S+ S + + L + G G G SL+G Sbjct: 980 IGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVEL-ERGPRGFGFSLRGG 1038 Query: 517 KSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLR 571 K ++G+FI + G A KDGR+ + DQ++ +NGE G ++ A+E ++ Sbjct: 1039 KEY----NMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQ 1089 Score = 53.9 bits (128), Expect = 8e-07 Identities = 31/94 (32%), Positives = 50/94 (53%), Gaps = 5/94 (5%) Query: 382 IKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDV 441 ++ LKK G GFT++ D + VKN+L G A +DG++ GD I+++NG V Sbjct: 409 VRASLKKSTMGFGFTIIGGDRPDEF---LQVKNVLKDGPAAQDGKIAPGDVIVDINGNCV 465 Query: 442 TGRTQEELVAMLRSTKQGETASLVIARQEGHFLP 475 G T ++V M + + +L + R G+ LP Sbjct: 466 LGHTHADVVQMFQLVPVNQYVNLTLCR--GYPLP 497 Score = 53.9 bits (128), Expect = 8e-07 Identities = 27/86 (31%), Positives = 49/86 (56%), Gaps = 3/86 (3%) Query: 370 LMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQS 429 ++G N+N ++L++GP G GF++ R + G +F+ + G AIKDGR+ Sbjct: 1008 VVGSRHNQNLGCYPVELERGPRGFGFSL--RGGKEYNMG-LFILRLAEDGPAIKDGRIHV 1064 Query: 430 GDRILEVNGRDVTGRTQEELVAMLRS 455 GD+I+E+NG G T + ++++ Sbjct: 1065 GDQIVEINGEPTQGITHTRAIELIQA 1090 Score = 53.5 bits (127), Expect = 1e-06 Identities = 75/322 (23%), Positives = 123/322 (38%), Gaps = 50/322 (15%) Query: 320 PPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRV---PRLGGKPSSPSLSPLMGFGSN 376 P ++G+S K + A Q KS L G + M + Sbjct: 512 PVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGS 571 Query: 377 KNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEV 436 + + I L KGP+G GF + P VK IL LQ GD I E+ Sbjct: 572 SQPELVTIPLIKGPKGFGFAIAD------SPTGQKVKMILDSQWC---QGLQKGDIIKEI 622 Query: 437 NGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPD-------CCALSL 489 ++V T ++V +L+ G L+I R + K + D A++ Sbjct: 623 YHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINE 682 Query: 490 ETSEQLTFEIPLNDSGSAGLGVSLKGNKSRET---------------------------- 521 + + F + SGS L S KS+ Sbjct: 683 PIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLG 742 Query: 522 --GTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGN 579 G D I+I +II GAA KDGRLR D+L+ ++G + GKS+ + ++ L + + G+ Sbjct: 743 GDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLD-LMTTAARNGH 801 Query: 580 IRGMIQLVILRRPERPMEDPAE 601 + ++ I ++P +D ++ Sbjct: 802 VLLTVRRKIFYGEKQPEDDSSQ 823 Score = 31.2 bits (69), Expect = 5.7 Identities = 10/40 (25%), Positives = 26/40 (65%) Query: 529 IKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAME 568 +K+++ G A +DG++ D ++ +NG +LG ++ + ++ Sbjct: 436 VKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQ 475 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.312 0.133 0.388 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 50,983,177 Number of Sequences: 37866 Number of extensions: 2982388 Number of successful extensions: 23128 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 392 Number of HSP's successfully gapped in prelim test: 814 Number of HSP's that attempted gapping in prelim test: 13374 Number of HSP's gapped (non-prelim): 6242 length of query: 1104 length of database: 18,247,518 effective HSP length: 113 effective length of query: 991 effective length of database: 13,968,660 effective search space: 13842942060 effective search space used: 13842942060 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.8 bits) S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.