Guide to the Human Genome
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Search of human proteins with 119120907

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|119120907 par-3 partitioning defective 3 homolog B isoform a
[Homo sapiens]
         (1104 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|119120907 par-3 partitioning defective 3 homolog B isoform a ...  2234   0.0  
gi|119120897 par-3 partitioning defective 3 homolog B isoform b ...  1642   0.0  
gi|119120903 par-3 partitioning defective 3 homolog B isoform c ...  1561   0.0  
gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]   538   e-152
gi|148746189 multiple PDZ domain protein [Homo sapiens]               107   5e-23
gi|112382257 InaD-like [Homo sapiens]                                 106   1e-22
gi|45827729 scribble isoform b [Homo sapiens]                          91   6e-18
gi|45827731 scribble isoform a [Homo sapiens]                          91   6e-18
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi...    86   3e-16
gi|24025688 ligand of numb-protein X 2 [Homo sapiens]                  85   3e-16
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]           83   1e-15
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i...    83   1e-15
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i...    83   1e-15
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is...    83   1e-15
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]           82   2e-15
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi...    82   3e-15
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa...    82   3e-15
gi|148833504 interleukin 16 isoform 2 [Homo sapiens]                   82   3e-15
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]                      81   6e-15
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]                      81   6e-15
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]                       81   6e-15
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i...    80   1e-14
gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens]       80   1e-14
gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens]       80   1e-14
gi|87196343 PDZ domain containing 2 [Homo sapiens]                     75   4e-13
gi|218505835 membrane-associated guanylate kinase-related  3 iso...    73   2e-12
gi|27262655 interleukin 16 isoform 1 precursor [Homo sapiens]          71   5e-12
gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo sa...    71   6e-12
gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo sa...    71   6e-12
gi|155969695 membrane-associated guanylate kinase-related  3 iso...    69   2e-11

>gi|119120907 par-3 partitioning defective 3 homolog B isoform a [Homo
            sapiens]
          Length = 1104

 Score = 2234 bits (5788), Expect = 0.0
 Identities = 1104/1104 (100%), Positives = 1104/1104 (100%)

Query: 1    MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD 60
            MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD
Sbjct: 1    MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD 60

Query: 61   PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG 120
            PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG
Sbjct: 61   PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG 120

Query: 121  EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL 180
            EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL
Sbjct: 121  EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL 180

Query: 181  NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS 240
            NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS
Sbjct: 181  NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS 240

Query: 241  RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV 300
            RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV
Sbjct: 241  RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV 300

Query: 301  IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG 360
            IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG
Sbjct: 301  IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG 360

Query: 361  KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA 420
            KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA
Sbjct: 361  KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA 420

Query: 421  AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKG 480
            AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKG
Sbjct: 421  AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKG 480

Query: 481  EPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFK 540
            EPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFK
Sbjct: 481  EPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFK 540

Query: 541  DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA 600
            DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA
Sbjct: 541  DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA 600

Query: 601  ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPT 660
            ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPT
Sbjct: 601  ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPT 660

Query: 661  PHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKV 720
            PHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKV
Sbjct: 661  PHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKV 720

Query: 721  HSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNES 780
            HSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNES
Sbjct: 721  HSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNES 780

Query: 781  FRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEK 840
            FRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEK
Sbjct: 781  FRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEK 840

Query: 841  EKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGL 900
            EKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGL
Sbjct: 841  EKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGL 900

Query: 901  REEELEKMKEERESGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWV 960
            REEELEKMKEERESGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWV
Sbjct: 901  REEELEKMKEERESGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWV 960

Query: 961  PGRGPDGNAHNLRFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHP 1020
            PGRGPDGNAHNLRFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHP
Sbjct: 961  PGRGPDGNAHNLRFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHP 1020

Query: 1021 PKGSYPRPTELRVADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPR 1080
            PKGSYPRPTELRVADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPR
Sbjct: 1021 PKGSYPRPTELRVADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPR 1080

Query: 1081 GGSPDQYPYRTQDSRQKNPMTAAV 1104
            GGSPDQYPYRTQDSRQKNPMTAAV
Sbjct: 1081 GGSPDQYPYRTQDSRQKNPMTAAV 1104


>gi|119120897 par-3 partitioning defective 3 homolog B isoform b [Homo
            sapiens]
          Length = 1143

 Score = 1642 bits (4252), Expect = 0.0
 Identities = 875/1054 (83%), Positives = 889/1054 (84%), Gaps = 108/1054 (10%)

Query: 1    MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD 60
            MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD
Sbjct: 1    MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD 60

Query: 61   PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG 120
            PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG
Sbjct: 61   PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG 120

Query: 121  EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL 180
            EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL
Sbjct: 121  EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL 180

Query: 181  NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS 240
            NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS
Sbjct: 181  NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS 240

Query: 241  RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV 300
            RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV
Sbjct: 241  RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV 300

Query: 301  IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG 360
            IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG
Sbjct: 301  IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG 360

Query: 361  KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA 420
            KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA
Sbjct: 361  KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA 420

Query: 421  AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKG 480
            AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPREL G
Sbjct: 421  AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELDG 480

Query: 481  EPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFK 540
                              + +ND   A  G SL G                         
Sbjct: 481  -----------------RLRMNDQLIAVNGESLLG------------------------- 498

Query: 541  DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA 600
                                KSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA
Sbjct: 499  --------------------KSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA 538

Query: 601  ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPT 660
            ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPT
Sbjct: 539  ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPT 598

Query: 661  PHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKV 720
            PHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKV
Sbjct: 599  PHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKV 658

Query: 721  HSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNES 780
            HSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNES
Sbjct: 659  HSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNES 718

Query: 781  FRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEK 840
            FRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEK
Sbjct: 719  FRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEK 778

Query: 841  EKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGL 900
            EKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGL
Sbjct: 779  EKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGL 838

Query: 901  REEELEKMKEERESGRPTGGSTDRIQKLRKEYYQARREGFPLY-----------EDDE-- 947
            REEELEKMKEERE          RI    +E  + +  G   Y           +DDE  
Sbjct: 839  REEELEKMKEERE----------RIGAKHQELREKQARGLLDYATGAIGSVYDMDDDEMD 888

Query: 948  -GRARPSEYDLLWVPGRGPDGNAHNLRFEGMERQYASLPRGGP-ADPVDYLPAAP----- 1000
               AR + +       R P  +A+  R         S PR GP   P D  P +P     
Sbjct: 889  PNYARVNHF-------REPCTSANVFR-------SPSPPRAGPFGYPRDGHPLSPERDHL 934

Query: 1001 RGLYKERELPYYP--GAHPMHPPKGSYPRPTELR 1032
             GLY +   PY+P   A    P  GS  R  +LR
Sbjct: 935  EGLYAKVNKPYHPLVPADSGRPTGGSTDRIQKLR 968



 Score =  419 bits (1077), Expect = e-117
 Identities = 191/192 (99%), Positives = 192/192 (100%)

Query: 913  ESGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDGNAHNL 972
            +SGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDGNAHNL
Sbjct: 952  DSGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDGNAHNL 1011

Query: 973  RFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELR 1032
            RFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELR
Sbjct: 1012 RFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELR 1071

Query: 1033 VADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQ 1092
            VADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQ
Sbjct: 1072 VADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQ 1131

Query: 1093 DSRQKNPMTAAV 1104
            DSRQKNPMTAAV
Sbjct: 1132 DSRQKNPMTAAV 1143


>gi|119120903 par-3 partitioning defective 3 homolog B isoform c [Homo
            sapiens]
          Length = 1136

 Score = 1561 bits (4043), Expect = 0.0
 Identities = 844/1054 (80%), Positives = 867/1054 (82%), Gaps = 115/1054 (10%)

Query: 1    MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD 60
            MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD
Sbjct: 1    MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD 60

Query: 61   PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG 120
            PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG
Sbjct: 61   PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG 120

Query: 121  EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL 180
            EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL
Sbjct: 121  EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL 180

Query: 181  NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS 240
            NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS
Sbjct: 181  NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS 240

Query: 241  RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV 300
            RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV
Sbjct: 241  RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV 300

Query: 301  IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG 360
            IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG
Sbjct: 301  IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG 360

Query: 361  KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA 420
            KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA
Sbjct: 361  KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA 420

Query: 421  AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKG 480
            AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKG
Sbjct: 421  AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKG 480

Query: 481  EPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFK 540
            EPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFK
Sbjct: 481  EPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFK 540

Query: 541  DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA 600
            DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA
Sbjct: 541  DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA 600

Query: 601  ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPT 660
            ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPT
Sbjct: 601  ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPT 660

Query: 661  PHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKV 720
            PHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKV
Sbjct: 661  PHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKV 720

Query: 721  HSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNES 780
            HSLAGQKS+          GL   SS                       H  +G      
Sbjct: 721  HSLAGQKSD----------GLSDKSS-----------------------HSGQG------ 741

Query: 781  FRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEK 840
                               L+ +S+  G   L  E       +++  + K +K +K K  
Sbjct: 742  ------------------ALNCESAPQGNSEL--EDMENKARKVKKTKEKEKKKEKGK-- 779

Query: 841  EKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGL 900
                    LKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGL
Sbjct: 780  --------LKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGL 831

Query: 901  REEELEKMKEERESGRPTGGSTDRIQKLRKEYYQARREGFPLY-----------EDDE-- 947
            REEELEKMKEERE          RI    +E  + +  G   Y           +DDE  
Sbjct: 832  REEELEKMKEERE----------RIGAKHQELREKQARGLLDYATGAIGSVYDMDDDEMD 881

Query: 948  -GRARPSEYDLLWVPGRGPDGNAHNLRFEGMERQYASLPRGGP-ADPVDYLPAAP----- 1000
               AR + +       R P  +A+  R         S PR GP   P D  P +P     
Sbjct: 882  PNYARVNHF-------REPCTSANVFR-------SPSPPRAGPFGYPRDGHPLSPERDHL 927

Query: 1001 RGLYKERELPYYP--GAHPMHPPKGSYPRPTELR 1032
             GLY +   PY+P   A    P  GS  R  +LR
Sbjct: 928  EGLYAKVNKPYHPLVPADSGRPTGGSTDRIQKLR 961



 Score =  419 bits (1077), Expect = e-117
 Identities = 191/192 (99%), Positives = 192/192 (100%)

Query: 913  ESGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDGNAHNL 972
            +SGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDGNAHNL
Sbjct: 945  DSGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDGNAHNL 1004

Query: 973  RFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELR 1032
            RFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELR
Sbjct: 1005 RFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELR 1064

Query: 1033 VADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQ 1092
            VADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQ
Sbjct: 1065 VADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQ 1124

Query: 1093 DSRQKNPMTAAV 1104
            DSRQKNPMTAAV
Sbjct: 1125 DSRQKNPMTAAV 1136


>gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]
          Length = 1356

 Score =  538 bits (1385), Expect = e-152
 Identities = 413/1147 (36%), Positives = 568/1147 (49%), Gaps = 239/1147 (20%)

Query: 154  SASHPG-GQSLKLVVPDSTQNLEDR---EVLNGVQTELLTSPRTKDTLSDMTRTVEISGE 209
            SASHP  G+ L+    D     ED    E +    T L   P    +L DM + VE+  +
Sbjct: 223  SASHPMVGKWLEKQEQDEDGTEEDNSRVEPVGHADTGLEHIPNF--SLDDMVKLVEVPND 280

Query: 210  GGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQ 269
            GGPLGIHVVPF S+  GR LGL ++ +E   +++ E LF EN+CIV+IN+ DL ++ F Q
Sbjct: 281  GGPLGIHVVPF-SARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQ 339

Query: 270  AQDVFRQAMKSPSVLLHVLPPQNREQYEK-SVIGSLNIFGNNDGVLKTKVPPPVHGKSGL 328
            AQ +FRQAM++P +  HV+P  N+EQYE+ S     N + +        +       +GL
Sbjct: 340  AQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGL 399

Query: 329  KT---ANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPL--------MGFGSNK 377
             T   A        + D+ + L  +  P     G  PS+P+ +P          G+ + K
Sbjct: 400  HTVQRAPRLNHPPEQIDSHSRLPHSAHPS----GKPPSAPASAPQNVFSTTVSSGYNTKK 455

Query: 378  NAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVN 437
              K++ I LKKG EGLGF++ +RD +I G  PI+VKNILP+GAAI+DGRL++GDR++EVN
Sbjct: 456  IGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVN 515

Query: 438  GRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETS----- 492
            G D+ G++QEE+V++LRSTK   T SL++ RQE  F PREL  EP    +  ET      
Sbjct: 516  GVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDED 575

Query: 493  ---------EQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGR 543
                     E LTFE+PLNDSGSAGLGVS+KGN+S+E   DLGIF+KSII+GGAA KDGR
Sbjct: 576  IVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGR 635

Query: 544  LRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRR------------ 591
            LR+NDQLIAVNGESLLGK+N +AMETLRRSMS EGN RGMIQL++ RR            
Sbjct: 636  LRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695

Query: 592  ---PERPMEDPAECGA--FSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLP 646
               PE P+E   +      S   +   +    +  RN  ++   +G          + +P
Sbjct: 696  PPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNA-ALSRIMGESGKYQLSPTVNMP 754

Query: 647  NDGWAESE------VPP------SPTPHSALGL--------------GLEDYSHSSGVDS 680
             D     E      +PP      S + H  +G                  D S S  VD 
Sbjct: 755  QDDTVIIEDDRLPVLPPHLSDQSSSSSHDDVGFVTADAGTWAKAAISDSADCSLSPDVDP 814

Query: 681  AVYFPDQHINFRSVTPAR--------QPESINLKASKSMDL-VPDESKVHSLAGQKSESP 731
             + F  +    +S++  R        Q + +  + SKSMDL + DE+K++++  QK+ SP
Sbjct: 815  VLAFQREGFGRQSMSEKRTKQFSDASQLDFVKTRKSKSMDLGIADETKLNTVDDQKAGSP 874

Query: 732  SKDFGPTLGLKKSSSLESLQTAVAEVRKN-DLPFHRPRPHMVRGRGCNESFRAAIDKSYD 790
            S+D GP+LGLKKSSSLESLQTAVAEV  N D+PFHRPRP ++RGRGCNESFRAAIDKSYD
Sbjct: 875  SRDVGPSLGLKKSSSLESLQTAVAEVTLNGDIPFHRPRPRIIRGRGCNESFRAAIDKSYD 934

Query: 791  GP----------------EEIEADGLSDKSSHSGQGALNCESAPQGNSELEDM-ENKARK 833
             P                EE    G    S+ S Q + + E    GN E  D  + K  K
Sbjct: 935  KPAVDDDDEGMETLEEDTEESSRSGRESVSTASDQPSHSLERQMNGNQEKGDKTDRKKDK 994

Query: 834  VKKTKEKEKKKEKGKLKVKE-------------KKRKEENEDPERKIK------------ 868
              K K+K++ KEK K+K K+             K RK++  +   KIK            
Sbjct: 995  TGKEKKKDRDKEKDKMKAKKGMLKGLGDMFRFGKHRKDDKIEKTGKIKIQESFTSEEERI 1054

Query: 869  -----KKGFGAMLRFGKKKEDK----------------------GGKAEQKGTL------ 895
                 ++   A  R  ++++ +                      GG +  +G++      
Sbjct: 1055 RMKQEQERIQAKTREFRERQARERDYAEIQDFHRTFGCDDELMYGGVSSYEGSMALNARP 1114

Query: 896  ---KHGGLREEELEKMKEER-------ESGRPTGGSTDRIQKLRKEYYQARREGFPLYED 945
               + G + +    ++K+ R       +S R T  + DRIQ+LR+E+ QA+++     ED
Sbjct: 1115 QSPREGHMMDALYAQVKKPRNSKPSPVDSNRSTPSNHDRIQRLRQEFQQAKQD-----ED 1169

Query: 946  DEGRARPSEYDLLWVPGR-GPDGNAHNLRFEGM---------------ERQYASLPRGGP 989
             E R R   ++  W   R       H++  E                 +RQY+SLPR   
Sbjct: 1170 VEDRRRTYSFEQPWPNARPATQSGRHSVSVEVQMQRQRQEERESSQQAQRQYSSLPRQSR 1229

Query: 990  ADPV---------DYLPAAPRGLYKERELPYYP----------GAHPMHPPKGSYPRPTE 1030
             +           +Y P    G    +E P Y           G H  +  +        
Sbjct: 1230 KNASSVSQDSWEQNYSPG--EGFQSAKENPRYSSYQGSRNGYLGGHGFNA-RVMLETQEL 1286

Query: 1031 LRVADLRYPQHY---PPPPAPQH---------------KGPFRQDVPPSPPQHQRMPAYQ 1072
            LR    R  Q     PP   P +               KGPFRQDVPPSP Q  R+   Q
Sbjct: 1287 LRQEQRRKEQQMKKQPPSEGPSNYDSYKKVQDPSYAPPKGPFRQDVPPSPSQVARLNRLQ 1346

Query: 1073 --ETGRP 1077
              E GRP
Sbjct: 1347 TPEKGRP 1353



 Score =  156 bits (395), Expect = 9e-38
 Identities = 78/146 (53%), Positives = 102/146 (69%), Gaps = 3/146 (2%)

Query: 1   MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD 60
           MKVTVCFGRT +VVPC +G ++V  L QQA+ RY K   K P YW+++H LE+ DGGILD
Sbjct: 1   MKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWIQVHRLEHGDGGILD 60

Query: 61  PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAA-QLAAFKP-- 117
            DD+L DV +DKD+L+AVF+EQ+P H  +  S +    QSP+ F +E+    ++AF+P  
Sbjct: 61  LDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQ 120

Query: 118 IGGEIEVTPSALKLGTPLLVRRSSDP 143
              EIEVTPS L+   PL VRRSSDP
Sbjct: 121 ATSEIEVTPSVLRANMPLHVRRSSDP 146


>gi|148746189 multiple PDZ domain protein [Homo sapiens]
          Length = 2041

 Score =  107 bits (268), Expect = 5e-23
 Identities = 139/583 (23%), Positives = 239/583 (40%), Gaps = 93/583 (15%)

Query: 65   LADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGGEIEV 124
            L   + ++D L  V  +    H + +  G         A + E+        PI   I +
Sbjct: 1493 LGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGY----PIEKFISL 1548

Query: 125  TPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVLNGVQ 184
              +A K+   L +   +      P+    ++      S  L+VP S    E   + N  +
Sbjct: 1549 LKTA-KMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSP-EPESIRNTSR 1606

Query: 185  TE----LLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS 240
            +       + P T   +     T+EIS     LG+ +V    +L G I+   I  + +  
Sbjct: 1607 SSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAII---IHEVYEEG 1663

Query: 241  RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLH--VLPPQNREQYEK 298
             + ++G     + I+++N +DL   T  +A +V RQ  +   + L+    P +  E  + 
Sbjct: 1664 AACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDT 1723

Query: 299  SVIG---------SLNIFG--NNDGVLKTKVPPPVHGKSGLKTAN-----------LTGT 336
              I           L+I G  N+ GV  + +      K G+  A+           + G 
Sbjct: 1724 LTIELQKKPGKGLGLSIVGKRNDTGVFVSDIV-----KGGIADADGRLMQGDQILMVNGE 1778

Query: 337  D--SPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKI------DLKK 388
            D  +   +A A+L +     +       S  S S  +   S KNA   +I      ++KK
Sbjct: 1779 DVRNATQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKK 1838

Query: 389  GP-EGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQE 447
            GP + LG ++     S  G  PIF+  + P G A +  +L+ GDRI+ + G    G T  
Sbjct: 1839 GPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHT 1898

Query: 448  ELVAMLRSTK--------QGETASLVIARQE-------------GHFLPRELKGEPDCCA 486
            + V +L++           G   S+V   Q+                + ++  G P C +
Sbjct: 1899 QAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKS 1958

Query: 487  LSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRM 546
            ++LE              G  GLG S+ G      G DL I++K++   GAA +DGRL+ 
Sbjct: 1959 ITLER-------------GPDGLGFSIVGGYGSPHG-DLPIYVKTVFAKGAASEDGRLKR 2004

Query: 547  NDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVIL 589
             DQ+IAVNG+SL G ++ EA+  L+R+       +G + L++L
Sbjct: 2005 GDQIIAVNGQSLEGVTHEEAVAILKRT-------KGTVTLMVL 2040



 Score =  106 bits (264), Expect = 1e-22
 Identities = 98/408 (24%), Positives = 182/408 (44%), Gaps = 63/408 (15%)

Query: 167  VPDSTQNLEDREVLNGVQTELLTSPRTKDTLS-DMTRTVEISGEGGPLGIHVVPFFSSLS 225
            +P +++NL+++E     +  + TS    D  S    + +E+  + G LGI +     S  
Sbjct: 1450 LPSNSENLQNKET----EPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAI-----SEE 1500

Query: 226  GRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLL 285
              + G+ I+ + ++  +  +G     + I+ +++  +V     +   + + A  +  + +
Sbjct: 1501 DTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI 1560

Query: 286  HVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASA 345
            H   P +  Q   S  G+ +                   K+  ++  +  + SPE ++  
Sbjct: 1561 HAENPDS--QAVPSAAGAAS----------------GEKKNSSQSLMVPQSGSPEPESIR 1602

Query: 346  SLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIH 405
            +  ++ +P +       S P+  P++         +  I++ KG  GLG ++V    ++ 
Sbjct: 1603 NTSRSSTPAI-----FASDPATCPIIP------GCETTIEISKGRTGLGLSIVGGSDTLL 1651

Query: 406  GPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLV 465
            G   I +  +  +GAA KDGRL +GD+ILEVNG D+   T +E + +LR T Q     L 
Sbjct: 1652 GA--IIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQ--RVRLT 1707

Query: 466  IARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDL 525
            + R E  +     K E  C  L++E          L      GLG+S+ G ++     D 
Sbjct: 1708 LYRDEAPY-----KEEEVCDTLTIE----------LQKKPGKGLGLSIVGKRN-----DT 1747

Query: 526  GIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 573
            G+F+  I+ GG A  DGRL   DQ++ VNGE +   +       L+ S
Sbjct: 1748 GVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVS 1795



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 86/278 (30%), Positives = 127/278 (45%), Gaps = 48/278 (17%)

Query: 343 ASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKN--AKKIKIDLKKGPEGLGFTVVTR 400
           A  SL Q  SP V R      SPS +  +   SN         I+L     GLGF ++  
Sbjct: 221 ARGSLPQLVSPIVSR------SPSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGG 274

Query: 401 DSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGE 460
            ++      + VK ILP G A + GRL SGD IL++   D+ G + E++  +LR    G 
Sbjct: 275 KAT-----GVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQC--GN 327

Query: 461 TASLVIARQEGHFLPRELKGEPDCCALSLETS-----------------EQLTFEIPLND 503
              L+IAR        E +  P    ++L +S                 E  TF++ L  
Sbjct: 328 RVKLMIARGA-----IEERTAPTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTK 382

Query: 504 SGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSN 563
           +   GLG+++ G    +     GIF+KSI    A   DGR+++ DQ+IAV+G +L G +N
Sbjct: 383 NVQ-GLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTN 441

Query: 564 HEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAE 601
            +A+E LR +           Q V+L    R M+  AE
Sbjct: 442 QQAVEVLRHTG----------QTVLLTLMRRGMKQEAE 469



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 116/436 (26%), Positives = 189/436 (43%), Gaps = 70/436 (16%)

Query: 174  LEDREVLNGVQTELLTSPRTKDTLSDMTRTVEISGEGGP-LGIHVVP---FFSSLS-GRI 228
            L +RE   G ++EL     T  +  +  R VE+  E    LGI +V      S LS G +
Sbjct: 1125 LPEREEGEGEESEL---QNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEV 1181

Query: 229  L-GLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLL-- 285
            + G+FI+ + ++S + + G     + IV+++ +DL D +  QA +  R+A  +P V +  
Sbjct: 1182 MRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKA-GNPVVFMVQ 1240

Query: 286  --------HVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTD 337
                      LP      Y K    S N F ++  +   K P     +S  + A L    
Sbjct: 1241 SIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPS--QSESEPEKAPLCSVP 1298

Query: 338  SPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG-SNKNAKKI---------KIDLK 387
             P   A A +  + +    +      S  +     FG S KN ++           I+L+
Sbjct: 1299 PPPPSAFAEMGSDHT----QSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELE 1354

Query: 388  KGPEGLGFTVV-TRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQ 446
            KG  GLG ++   +D S      +F+  I P GAA KDGRLQ  D +LE+NG+ + GR+ 
Sbjct: 1355 KGHSGLGLSLAGNKDRSRMS---VFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSH 1411

Query: 447  EELVAMLR-----------STKQGETASLVIARQEGHFLP------RELKGEPDC----C 485
            +   ++++             K       V        LP      +  + EP       
Sbjct: 1412 QNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDA 1471

Query: 486  ALSLETSEQLT-FEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRL 544
            A+ L + + +   E+P  D G  G+ +S       E  T  G+ IKS+   G A  DGRL
Sbjct: 1472 AVDLSSFKNVQHLELP-KDQGGLGIAIS-------EEDTLSGVIIKSLTEHGVAATDGRL 1523

Query: 545  RMNDQLIAVNGESLLG 560
            ++ DQ++AV+ E ++G
Sbjct: 1524 KVGDQILAVDDEIVVG 1539



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 81/308 (26%), Positives = 134/308 (43%), Gaps = 26/308 (8%)

Query: 271 QDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKT 330
           + V +  + S  + L     Q ++Q   +   + NI   +   L   V P +  +S L +
Sbjct: 37  KSVLQSPLFSQILSLQTSVQQLKDQVNIATSATSNIEYAHVPHLSPAVIPTLQNESFLLS 96

Query: 331 ANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGP 390
            N           + +L+    P +P + GKP+      L+   +     ++   LK   
Sbjct: 97  PN-----------NGNLEALTGPGIPHINGKPACDEFDQLIKNMAQGRHVEVFELLKPPS 145

Query: 391 EGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGR-TQEEL 449
            GLGF+VV   S   G   IFV+ I     A +DGRL+  D+IL +NG+ +    T ++ 
Sbjct: 146 GGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQA 205

Query: 450 VAMLRSTKQGETASLVIARQE-----GHFLPRELKGEPDCCALSLETSEQLTFEIPLNDS 504
           +++L+  K  +T  LVIAR          + R         A S     Q    I L + 
Sbjct: 206 ISILQKAK--DTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVND 263

Query: 505 GSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNH 564
           GS GLG  + G K+       G+ +K+I+ GG A + GRL   D ++ +    L G S+ 
Sbjct: 264 GS-GLGFGIIGGKA------TGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSE 316

Query: 565 EAMETLRR 572
           +  + LR+
Sbjct: 317 QVAQVLRQ 324



 Score = 80.5 bits (197), Expect = 8e-15
 Identities = 111/486 (22%), Positives = 189/486 (38%), Gaps = 85/486 (17%)

Query: 186 ELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKRE 245
           EL     T+      T  VE++     LGI +  +         G+F++ I  +S  + +
Sbjct: 360 ELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHD 419

Query: 246 GLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYE----KSVI 301
           G     + I+ ++  +L   T  QA +V R      +VLL ++    +++ E    + V 
Sbjct: 420 GRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHT--GQTVLLTLMRRGMKQEAELMSREDVT 477

Query: 302 GSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTD-------SPETDASASLQQNKSPR 354
              ++   N  ++K          S  +  N+  T+       S E +     Q+ ++  
Sbjct: 478 KDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAAL 537

Query: 355 VPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKN 414
           + +            +MG     N + +   + K  E  G  +    +  H     F+++
Sbjct: 538 LTKW---------QRIMGI----NYEIVVAHVSKFSENSGLGISLEATVGHH----FIRS 580

Query: 415 ILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRS----------------TKQ 458
           +LP+G     G+L SGD +LEVNG  + G   +++V +L+                 T Q
Sbjct: 581 VLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQ 640

Query: 459 GETASLVIARQE---------GHFLPRELKGEPDCCALSLETSEQLTFEI--PLN----- 502
            E  SL +   E         G F+      +P    L++  + Q T E+  PL      
Sbjct: 641 SELDSLDLCDIELTEKPHVDLGEFIGSSETEDP---VLAMTDAGQSTEEVQAPLAMWEAG 697

Query: 503 ------DSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGE 556
                 + GS GLG S+   +         I I+S++ GG A KDGRL   D+L+ VN  
Sbjct: 698 IQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDV 757

Query: 557 SLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPER------------PMEDPAECGA 604
           +L   S  EA+E L+ + S  G +R  +   +   PE             P     E G 
Sbjct: 758 NLENSSLEEAVEALKGAPS--GTVRIGVAKPLPLSPEEGYVSAKEDSFLYPPHSCEEAGL 815

Query: 605 FSKPCF 610
             KP F
Sbjct: 816 ADKPLF 821



 Score = 71.6 bits (174), Expect = 4e-12
 Identities = 118/503 (23%), Positives = 194/503 (38%), Gaps = 129/503 (25%)

Query: 211 GPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDK-TFAQ 269
           G LG  VV   S   G  LG+F++ I++ S + R+G   E + I+ IN   L    T  Q
Sbjct: 146 GGLGFSVVGLRSENRGE-LGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQ 204

Query: 270 AQDVFRQA---------------------MKSPS----VLLHVLPP--QNREQYEKSVIG 302
           A  + ++A                      +SPS    +  H  P   Q+ E  E    G
Sbjct: 205 AISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVNDG 264

Query: 303 SLNIFGNNDG-----VLKTKVPPPV---HGK--SG-----LKTANLTGTDSPETD----- 342
           S   FG   G     ++KT +P  V   HG+  SG     +   +L G  S +       
Sbjct: 265 SGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQ 324

Query: 343 ---------ASASLQQNKSPR---VPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGP 390
                    A  ++++  +P    +       S+P L         + ++   ++L K  
Sbjct: 325 CGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTKNV 384

Query: 391 EGLGFTVV--TRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEE 448
           +GLG T+     D  +  P  IFVK+I    A   DGR+Q GD+I+ V+G ++ G T ++
Sbjct: 385 QGLGITIAGYIGDKKLE-PSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQ 443

Query: 449 LVAMLRSTKQGETASLVIAR---------------------------------------- 468
            V +LR T  G+T  L + R                                        
Sbjct: 444 AVEVLRHT--GQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKENYEKDEDFL 501

Query: 469 ---QEGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLK------GNKSR 519
              +  + LP E +G P   A   E  +    E  L       +G++ +         S 
Sbjct: 502 SSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSE 561

Query: 520 ETGTDLGI-------FIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRR 572
            +G  + +       FI+S++  G     G+L   D+L+ VNG +LLG+ NH+ +  + +
Sbjct: 562 NSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGE-NHQDVVNILK 620

Query: 573 SMSMEGNIRGMIQLVILRRPERP 595
            + +E      + +V  RR   P
Sbjct: 621 ELPIE------VTMVCCRRTVPP 637



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 65/259 (25%), Positives = 114/259 (44%), Gaps = 46/259 (17%)

Query: 376  NKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILE 435
            +K + +  I++ KG   LG TV      +     + V++I+  GA  +DGR+  GD IL 
Sbjct: 1001 SKESFERTINIAKGNSSLGMTVSANKDGLG----MIVRSIIHGGAISRDGRIAIGDCILS 1056

Query: 436  VNGRDVTGRTQEELVAMLRS--------------TKQGETASLVIARQEGHF-------- 473
            +N       T  +  AMLR                +  E   + + +Q G          
Sbjct: 1057 INEESTISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSS 1116

Query: 474  --------LPRELKGEPDCCAL--SLETSEQLTFEIPLNDSGSAGLGVSLKGNK---SRE 520
                    LP   +GE +   L  +  ++      + L    S  LG+S+ G +   SR 
Sbjct: 1117 YTGRDIPELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRL 1176

Query: 521  TGTDL--GIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEG 578
            +  ++  GIFIK ++    A K+G L+  D+++ V+G  L   S+ +A+E +R++    G
Sbjct: 1177 SNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKA----G 1232

Query: 579  N-IRGMIQLVILRRPERPM 596
            N +  M+Q +I R  + P+
Sbjct: 1233 NPVVFMVQSIINRPRKSPL 1251



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 66/260 (25%), Positives = 117/260 (45%), Gaps = 44/260 (16%)

Query: 202  RTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVD 261
            RT+ I+     LG+ V     S +   LG+ +R I       R+G     +CI+ IN   
Sbjct: 1007 RTINIAKGNSSLGMTV-----SANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEES 1061

Query: 262  LVDKTFAQAQDVFRQ-AMKSPSVLLHVLPPQNREQYEKSV------IGSLNIFGNNDGVL 314
             +  T AQA+ + R+ ++  P + +  +P ++ E+++ S+      + +L+IF +  G  
Sbjct: 1062 TISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRD 1121

Query: 315  KTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG 374
              ++P    G+           +  E   +A    N+ PR   L  +PS           
Sbjct: 1122 IPELPEREEGEG----------EESELQNTAYSNWNQ-PRRVELWREPS----------- 1159

Query: 375  SNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRIL 434
                 K + I +  G  G+G    +R S+      IF+K++L    A K+G L+ GDRI+
Sbjct: 1160 -----KSLGISI-VGGRGMG----SRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIV 1209

Query: 435  EVNGRDVTGRTQEELVAMLR 454
            EV+G D+   + E+ V  +R
Sbjct: 1210 EVDGMDLRDASHEQAVEAIR 1229



 Score = 57.8 bits (138), Expect = 6e-08
 Identities = 29/69 (42%), Positives = 44/69 (63%), Gaps = 3/69 (4%)

Query: 503  DSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKS 562
            + G +GLG+SL GNK R     + +FI  I   GAA KDGRL++ D+L+ +NG+ L G+S
Sbjct: 1354 EKGHSGLGLSLAGNKDRSR---MSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRS 1410

Query: 563  NHEAMETLR 571
            +  A   ++
Sbjct: 1411 HQNASSIIK 1419



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 32/85 (37%), Positives = 51/85 (60%), Gaps = 7/85 (8%)

Query: 506 SAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHE 565
           S GLG S+ G +S   G +LGIF++ I  G  A +DGRL+  DQ++A+NG++L     H+
Sbjct: 145 SGGLGFSVVGLRSENRG-ELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQ 203

Query: 566 AMETLRRSMSMEGNIRGMIQLVILR 590
                 +++S+    +  +QLVI R
Sbjct: 204 ------QAISILQKAKDTVQLVIAR 222



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 30/85 (35%), Positives = 53/85 (62%), Gaps = 6/85 (7%)

Query: 489  LETSEQLTFEIPLNDS-GSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMN 547
            L+   + +FE  +N + G++ LG+++  NK       LG+ ++SIIHGGA  +DGR+ + 
Sbjct: 997  LQNVSKESFERTINIAKGNSSLGMTVSANKD-----GLGMIVRSIIHGGAISRDGRIAIG 1051

Query: 548  DQLIAVNGESLLGKSNHEAMETLRR 572
            D ++++N ES +  +N +A   LRR
Sbjct: 1052 DCILSINEESTISVTNAQARAMLRR 1076


>gi|112382257 InaD-like [Homo sapiens]
          Length = 1801

 Score =  106 bits (265), Expect = 1e-22
 Identities = 106/412 (25%), Positives = 180/412 (43%), Gaps = 95/412 (23%)

Query: 211 GPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQA 270
           G LG  VV   S   G++  +F++ ++  S + R+    EN+ I+ IN+  L D+  +  
Sbjct: 143 GGLGFSVVALRSQNLGKV-DIFVKDVQPGSVADRDQRLKENDQILAINHTPL-DQNISHQ 200

Query: 271 QDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKT 330
           Q +          LL            +   GSL +    +         PVH KS   +
Sbjct: 201 QAI---------ALL------------QQTTGSLRLIVARE---------PVHTKSST-S 229

Query: 331 ANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGP 390
           ++L  T  PET     +++                                  ++L    
Sbjct: 230 SSLNDTTLPETVCWGHVEE----------------------------------VELINDG 255

Query: 391 EGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELV 450
            GLGF +V   +S      + V+ I+P G A +DGRLQ+GD IL++ G +V G T E++ 
Sbjct: 256 SGLGFGIVGGKTS-----GVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVA 310

Query: 451 AMLRSTKQGETASLVIARQEGHFL------PRELKGEPDCCALSLETSEQLTFE---IPL 501
            +LR+   G +  +++AR     +      P  L       A     S+   FE   + L
Sbjct: 311 QVLRNC--GNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSSLFETYNVEL 368

Query: 502 NDSGSAGLGVSLKGNK-SRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLG 560
                  LG+ + G   +  TG   GI++KSII G AA+ +G +++ND+++AV+G ++ G
Sbjct: 369 VRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQG 428

Query: 561 KSNHEAMETLRRSMSMEGNIRGMIQLVILRR----PERPMEDPAECGAFSKP 608
            +NH+ +E LR       N   ++ L ++RR       P+E P++ G   +P
Sbjct: 429 FANHDVVEVLR-------NAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEP 473



 Score =  103 bits (256), Expect = 1e-21
 Identities = 107/454 (23%), Positives = 189/454 (41%), Gaps = 73/454 (16%)

Query: 164  KLVVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMT---RTVEISGEGGPLGIHVVPF 220
            K +  DS +N E+         +  T  + +   +D+      +E+  +   LG+ +   
Sbjct: 1206 KALTDDSDENEEE---------DAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLA-- 1254

Query: 221  FSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKS 280
              +     + +F+ GI     +  +G     + +++INN  L  ++   A  + + A   
Sbjct: 1255 -GNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSK 1313

Query: 281  PSVL----------LHVLP---PQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSG 327
              ++          + V P   P +     +   G+  I    DG ++  +      +S 
Sbjct: 1314 VKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESESF 1373

Query: 328  LKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNA-------- 379
                +        T  S S Q+   P  P      +    +   GF +  +         
Sbjct: 1374 KLAVSQMKQQKYPTKVSFSSQE--IPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIV 1431

Query: 380  --KKIKIDLKKGPEGLGFTVVT-RDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEV 436
              +++ I++ KG  GLG ++V  +D+ ++    I +  +  +GAA +DGRL +GD+ILEV
Sbjct: 1432 PGQEMIIEISKGRSGLGLSIVGGKDTPLNA---IVIHEVYEEGAAARDGRLWAGDQILEV 1488

Query: 437  NGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLT 496
            NG D+   + EE +  LR T Q     LV+ R E H+   E          +LE      
Sbjct: 1489 NGVDLRNSSHEEAITALRQTPQ--KVRLVVYRDEAHYRDEE----------NLE-----I 1531

Query: 497  FEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGE 556
            F + L      GLG+S+ G ++       G+FI  I+ GGAA  DGRL   DQ+++VNGE
Sbjct: 1532 FPVDLQKKAGRGLGLSIVGKRNGS-----GVFISDIVKGGAADLDGRLIQGDQILSVNGE 1586

Query: 557  SLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILR 590
             +   S       L+ +       +G++QL I R
Sbjct: 1587 DMRNASQETVATILKCA-------QGLVQLEIGR 1613



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 69/271 (25%), Positives = 124/271 (45%), Gaps = 36/271 (13%)

Query: 333 LTGTDSPETDASASLQQNKS------PRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDL 386
           L  TD   T+ +     N S      P  P+LG +  +   S +      +  + I I+ 
Sbjct: 83  LVFTDGSITNGNVHRPSNNSTVSGLFPWTPKLGNEDFN---SVIQQMAQGRQIEYIDIE- 138

Query: 387 KKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGR-T 445
           +    GLGF+VV   S   G   IFVK++ P   A +D RL+  D+IL +N   +    +
Sbjct: 139 RPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNIS 198

Query: 446 QEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTF----EIPL 501
            ++ +A+L+ T    +  L++AR+     P   K             E + +    E+ L
Sbjct: 199 HQQAIALLQQTT--GSLRLIVARE-----PVHTKSSTSSSLNDTTLPETVCWGHVEEVEL 251

Query: 502 NDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGK 561
            + GS GLG  + G K+       G+ +++I+ GG A +DGRL+  D ++ + G ++ G 
Sbjct: 252 INDGS-GLGFGIVGGKTS------GVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGM 304

Query: 562 SNHEAMETLRRSMSMEGNIRGMIQLVILRRP 592
           ++ +  + LR       N    +++++ R P
Sbjct: 305 TSEQVAQVLR-------NCGNSVRMLVARDP 328



 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 68/235 (28%), Positives = 108/235 (45%), Gaps = 41/235 (17%)

Query: 373  FGSNKNAKKIKIDL-KKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGD 431
            +   +N +   +DL KK   GLG ++V + +   G G +F+ +I+  GAA  DGRL  GD
Sbjct: 1523 YRDEENLEIFPVDLQKKAGRGLGLSIVGKRN---GSG-VFISDIVKGGAADLDGRLIQGD 1578

Query: 432  RILEVNGRDVTGRTQEELVAML----------------------RSTKQGETASLVIARQ 469
            +IL VNG D+   +QE +  +L                      R+T Q    S   A  
Sbjct: 1579 QILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHS 1638

Query: 470  EGH--FLP-----RELKGEPDCCALSLETS----EQLTFEIPLNDSGSAGLGVSLKGNKS 518
              H  F P     + L G       S + S    E  T EI  N   S  LG+S+ G + 
Sbjct: 1639 SCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEI--NRELSDALGISIAGGRG 1696

Query: 519  RETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 573
               G D+ +FI  I   G A +  +L++ D+++++NG+ L G S+ + +  L+ +
Sbjct: 1697 SPLG-DIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNA 1750



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 60/249 (24%), Positives = 102/249 (40%), Gaps = 60/249 (24%)

Query: 394  GFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAML 453
            G TV+ R  +      IF+K +L    A K   L++GD+ILEV+G D+   +  E V  +
Sbjct: 1086 GQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAI 1145

Query: 454  RST------------------------------KQGETASLVIARQEGHFLPRELKGEPD 483
            ++                                Q +       +++G   P  +K  P 
Sbjct: 1146 KNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGT-APPPMKLPPP 1204

Query: 484  CCALSLETSE-------------QLTFEIPLN------DSGSAGLGVSLKGNKSRETGTD 524
              AL+ ++ E             Q   ++P        +    GLG+SL GNK R     
Sbjct: 1205 YKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSR--- 1261

Query: 525  LGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMI 584
            + IF+  I   G A  DGR+R+ D+L+ +N + L G+S+  A   ++ + S        +
Sbjct: 1262 MSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPS-------KV 1314

Query: 585  QLVILRRPE 593
            +LV +R  +
Sbjct: 1315 KLVFIRNED 1323



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 92/428 (21%), Positives = 166/428 (38%), Gaps = 70/428 (16%)

Query: 191 PRTKDTLSDMTRTVEISGEGGPLGIHVVPFF-SSLSGRILGLFIRGIEDNSRSKREGLFH 249
           P +  +L +      +  +G  LGI +V +  +S +G   G++++ I   S +   G   
Sbjct: 354 PGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQ 413

Query: 250 ENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGN 309
            N+ IV ++ V++  + FA    V  + +++   ++H+   + +     S +   +  G 
Sbjct: 414 VNDKIVAVDGVNI--QGFANHDVV--EVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGT 469

Query: 310 NDGVLKTKVPPPVHGKSGLKT-ANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLS 368
              V++   PP +     ++T  N+ G D    +   +L+ +    + +L   P SP   
Sbjct: 470 ---VVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSP--- 523

Query: 369 PLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPI------------------ 410
                   +N  K + +   GP+     V T D+ I     +                  
Sbjct: 524 --------ENELKSRWENLLGPD-YEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEV 574

Query: 411 -------FVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETAS 463
                  ++ +I+  G     G LQ  D +LEVNG  + G+++ E V+ L+      T  
Sbjct: 575 DSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFT-- 632

Query: 464 LVIARQEGHFLPRELKGEPDCCALSL---ETSEQLTFEIPLNDSGS-------------- 506
           LV  R+   F       EP     SL   E    +      +D G               
Sbjct: 633 LVCCRR--LFDDEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELV 690

Query: 507 ---AGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSN 563
               GLG S+   +     T   I I+S++  G A + G L   D+L++VN   L   S 
Sbjct: 691 KDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSL 750

Query: 564 HEAMETLR 571
            EA+E L+
Sbjct: 751 AEAVEILK 758



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 74/319 (23%), Positives = 136/319 (42%), Gaps = 58/319 (18%)

Query: 171  TQNLEDREVLNGVQTELLTS---PRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGR 227
            T  L +RE   G +T   +    PR  +   +   ++ IS  GG   I  +     L G 
Sbjct: 1043 TCELPEREEGEGEETPNFSHWGPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKG- 1101

Query: 228  ILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHV 287
               +FI+ + ++S + +       + I++++ VDL + + ++A +  + A  +P V    
Sbjct: 1102 ---IFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNA-GNPVVF--- 1154

Query: 288  LPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASL 347
                        ++ SL+           +V P VH K+      +TG  + +T      
Sbjct: 1155 ------------IVQSLSS--------TPRVIPNVHNKAN----KITGNQNQDTQEKKEK 1190

Query: 348  QQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNA---KKIK------------IDLKKGPEG 392
            +Q  +P  P +   P   +L+        ++A   +KI+            I+L+K   G
Sbjct: 1191 RQGTAP--PPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNG 1248

Query: 393  LGFTVV-TRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVA 451
            LG ++   +D S      IFV  I P+G A  DGR++ GD +LE+N + + GR+ +   A
Sbjct: 1249 LGLSLAGNKDRSRMS---IFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASA 1305

Query: 452  MLRSTKQGETASLVIARQE 470
            ++++        LV  R E
Sbjct: 1306 IIKTAP--SKVKLVFIRNE 1322



 Score = 40.0 bits (92), Expect = 0.012
 Identities = 23/73 (31%), Positives = 40/73 (54%), Gaps = 5/73 (6%)

Query: 506  SAGLGVSLKGN----KSRETGTDL-GIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLG 560
            +  LG+S+ G     K  + G +L GIFIK ++    A K   L+  D+++ V+G  L  
Sbjct: 1076 NVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQN 1135

Query: 561  KSNHEAMETLRRS 573
             S+ EA+E ++ +
Sbjct: 1136 ASHSEAVEAIKNA 1148


>gi|45827729 scribble isoform b [Homo sapiens]
          Length = 1630

 Score = 90.9 bits (224), Expect = 6e-18
 Identities = 114/438 (26%), Positives = 180/438 (41%), Gaps = 102/438 (23%)

Query: 147  PPADTQPSASHPGGQSLKLVVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMTRTVEI 206
            P  D  P     GG  L L+ P+S   L  R V    ++E               R +  
Sbjct: 830  PEDDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSE---------------RGLGF 874

Query: 207  SGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKT 266
            S  GG       P+ +  +G    +F+  I +   + R G     + ++ IN VD+ +  
Sbjct: 875  SIAGGKGS---TPYRAGDAG----IFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEAR 927

Query: 267  FAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKS 326
               A  +   A  + ++LL           E+   G L               PP     
Sbjct: 928  HDHAVSLLTAASPTIALLL-----------EREAGGPL---------------PP----- 956

Query: 327  GLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKN---AKKIK 383
                + L  +  P    + +     +P VP L      PSL+P +   + +     ++I+
Sbjct: 957  ----SPLPHSSPPTAAVATTSITTATPGVPGL------PSLAPSLLAAALEGPYPVEEIR 1006

Query: 384  IDLKKGPEGLGFTVVTRDSS----IHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGR 439
            +    GP GL     +  SS    +  PG +F+  +LP+G A + G L+ GDRIL VNG+
Sbjct: 1007 LPRAGGPLGLSIVGGSDHSSHPFGVQEPG-VFISKVLPRGLAARSG-LRVGDRILAVNGQ 1064

Query: 440  DVTGRTQEELV-AMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFE 498
            DV   T +E V A+LR   +    SL++ R      P  L+                  E
Sbjct: 1065 DVRDATHQEAVSALLRPCLE---LSLLVRRDPA---PPGLR------------------E 1100

Query: 499  IPLNDSGSAGLGVSLKGNKSRETG-----TDLGIFIKSIIHGGAAFKDGRLRMNDQLIAV 553
            + +  +    LG+S++G      G     TD GIFI  +   GAA +DGRLR+  +L+ V
Sbjct: 1101 LCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEV 1160

Query: 554  NGESLLGKSNHEAMETLR 571
            N +SLLG ++ EA++ LR
Sbjct: 1161 NQQSLLGLTHGEAVQLLR 1178



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 52/212 (24%), Positives = 89/212 (41%), Gaps = 22/212 (10%)

Query: 380 KKIKIDLKKGPEGLGFTVVTRDSSIHGPGP---IFVKNILPKGAAIKDGRLQSGDRILEV 436
           +++ + + +   GLG ++     S    G    IF+  +  +G A + G ++ GD++LEV
Sbjct: 725 EELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEV 783

Query: 437 NGRDVTGRTQEELVAMLRST--------------KQGETASLVIARQEGHFLPRELKGEP 482
           NG  + G    E V  LR                +     ++   R E  + PRE +G  
Sbjct: 784 NGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGG 843

Query: 483 DCCALSLETSEQLTFE--IPLNDSGSAGLGVSLKGNKSRET--GTDLGIFIKSIIHGGAA 538
               L    S     +  +        GLG S+ G K        D GIF+  I  GGAA
Sbjct: 844 LRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAA 903

Query: 539 FKDGRLRMNDQLIAVNGESLLGKSNHEAMETL 570
            + G L++ D+++++NG  +    +  A+  L
Sbjct: 904 HRAGTLQVGDRVLSINGVDVTEARHDHAVSLL 935



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 44/130 (33%), Positives = 62/130 (47%), Gaps = 11/130 (8%)

Query: 444 RTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLND 503
           R +EE  +     K+G   S    +         L  EP     +    E+LT  I L  
Sbjct: 681 RAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEP-----ARIEEEELTLTI-LRQ 734

Query: 504 SGSAGLGVSLKGNKSRET--GTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGK 561
           +G  GLG+S+ G K      G D GIFI  +   G A + G +R+ D+L+ VNG +L G 
Sbjct: 735 TG--GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGA 791

Query: 562 SNHEAMETLR 571
            +HEA+E LR
Sbjct: 792 EHHEAVEALR 801



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 25/57 (43%), Positives = 38/57 (66%), Gaps = 2/57 (3%)

Query: 410  IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVI 466
            IF+  + P GAA +DGRL+ G R+LEVN + + G T  E V +LRS   G+T ++++
Sbjct: 1134 IFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSV--GDTLTVLV 1188


>gi|45827731 scribble isoform a [Homo sapiens]
          Length = 1655

 Score = 90.9 bits (224), Expect = 6e-18
 Identities = 114/438 (26%), Positives = 180/438 (41%), Gaps = 102/438 (23%)

Query: 147  PPADTQPSASHPGGQSLKLVVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMTRTVEI 206
            P  D  P     GG  L L+ P+S   L  R V    ++E               R +  
Sbjct: 830  PEDDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSE---------------RGLGF 874

Query: 207  SGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKT 266
            S  GG       P+ +  +G    +F+  I +   + R G     + ++ IN VD+ +  
Sbjct: 875  SIAGGKGS---TPYRAGDAG----IFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEAR 927

Query: 267  FAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKS 326
               A  +   A  + ++LL           E+   G L               PP     
Sbjct: 928  HDHAVSLLTAASPTIALLL-----------EREAGGPL---------------PP----- 956

Query: 327  GLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKN---AKKIK 383
                + L  +  P    + +     +P VP L      PSL+P +   + +     ++I+
Sbjct: 957  ----SPLPHSSPPTAAVATTSITTATPGVPGL------PSLAPSLLAAALEGPYPVEEIR 1006

Query: 384  IDLKKGPEGLGFTVVTRDSS----IHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGR 439
            +    GP GL     +  SS    +  PG +F+  +LP+G A + G L+ GDRIL VNG+
Sbjct: 1007 LPRAGGPLGLSIVGGSDHSSHPFGVQEPG-VFISKVLPRGLAARSG-LRVGDRILAVNGQ 1064

Query: 440  DVTGRTQEELV-AMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFE 498
            DV   T +E V A+LR   +    SL++ R      P  L+                  E
Sbjct: 1065 DVRDATHQEAVSALLRPCLE---LSLLVRRDPA---PPGLR------------------E 1100

Query: 499  IPLNDSGSAGLGVSLKGNKSRETG-----TDLGIFIKSIIHGGAAFKDGRLRMNDQLIAV 553
            + +  +    LG+S++G      G     TD GIFI  +   GAA +DGRLR+  +L+ V
Sbjct: 1101 LCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEV 1160

Query: 554  NGESLLGKSNHEAMETLR 571
            N +SLLG ++ EA++ LR
Sbjct: 1161 NQQSLLGLTHGEAVQLLR 1178



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 52/212 (24%), Positives = 89/212 (41%), Gaps = 22/212 (10%)

Query: 380 KKIKIDLKKGPEGLGFTVVTRDSSIHGPGP---IFVKNILPKGAAIKDGRLQSGDRILEV 436
           +++ + + +   GLG ++     S    G    IF+  +  +G A + G ++ GD++LEV
Sbjct: 725 EELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEV 783

Query: 437 NGRDVTGRTQEELVAMLRST--------------KQGETASLVIARQEGHFLPRELKGEP 482
           NG  + G    E V  LR                +     ++   R E  + PRE +G  
Sbjct: 784 NGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGG 843

Query: 483 DCCALSLETSEQLTFE--IPLNDSGSAGLGVSLKGNKSRET--GTDLGIFIKSIIHGGAA 538
               L    S     +  +        GLG S+ G K        D GIF+  I  GGAA
Sbjct: 844 LRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAA 903

Query: 539 FKDGRLRMNDQLIAVNGESLLGKSNHEAMETL 570
            + G L++ D+++++NG  +    +  A+  L
Sbjct: 904 HRAGTLQVGDRVLSINGVDVTEARHDHAVSLL 935



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 44/130 (33%), Positives = 62/130 (47%), Gaps = 11/130 (8%)

Query: 444 RTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLND 503
           R +EE  +     K+G   S    +         L  EP     +    E+LT  I L  
Sbjct: 681 RAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEP-----ARIEEEELTLTI-LRQ 734

Query: 504 SGSAGLGVSLKGNKSRET--GTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGK 561
           +G  GLG+S+ G K      G D GIFI  +   G A + G +R+ D+L+ VNG +L G 
Sbjct: 735 TG--GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGA 791

Query: 562 SNHEAMETLR 571
            +HEA+E LR
Sbjct: 792 EHHEAVEALR 801



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 25/57 (43%), Positives = 38/57 (66%), Gaps = 2/57 (3%)

Query: 410  IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVI 466
            IF+  + P GAA +DGRL+ G R+LEVN + + G T  E V +LRS   G+T ++++
Sbjct: 1134 IFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSV--GDTLTVLV 1188


>gi|119943106 synapse-associated protein 102 isoform a [Homo
           sapiens]
          Length = 817

 Score = 85.5 bits (210), Expect = 3e-16
 Identities = 85/298 (28%), Positives = 128/298 (42%), Gaps = 50/298 (16%)

Query: 374 GSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGD 431
           GS+   K  +I L++G  GLGF++     + H P    IF+  I+P GAA  DGRL   D
Sbjct: 122 GSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVND 181

Query: 432 RILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLET 491
            +L VN  DV+       V  L+    G    LV+ R++                     
Sbjct: 182 CVLRVNEVDVSEVVHSRAVEALKEA--GPVVRLVVRRRQ--------------------P 219

Query: 492 SEQLTFEIPLNDSGSAGLGVSLKGN-KSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQL 550
             +   E+ L   G  GLG S+ G   ++    D  I+I  II GGAA KDGRL++ D+L
Sbjct: 220 PPETIMEVNLL-KGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRL 278

Query: 551 IAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKPCF 610
           +AVN  +L    + EA+ +L+       N   M+ L + +     + D      ++ P +
Sbjct: 279 LAVNNTNLQDVRHEEAVASLK-------NTSDMVYLKVAKPGSLHLND-----MYAPPDY 326

Query: 611 ENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPP---SPTPHSAL 665
            +   A+  +  + NS L  LG    +             A  +VPP   SP P   L
Sbjct: 327 ASTFTALADNHISHNSSLGYLGAVESKVSYP---------APPQVPPTRYSPIPRHML 375



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 67/239 (28%), Positives = 108/239 (45%), Gaps = 55/239 (23%)

Query: 382 IKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGDRILEVNGR 439
           ++++L KGP+GLGF++     + H PG   I++  I+  GAA KDGRLQ GDR+L VN  
Sbjct: 225 MEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNT 284

Query: 440 DVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCC-------------- 485
           ++     EE VA L++T   +   L +A+  G     ++   PD                
Sbjct: 285 NLQDVRHEEAVASLKNTS--DMVYLKVAKP-GSLHLNDMYAPPDYASTFTALADNHISHN 341

Query: 486 -------ALSLETSEQLTFEIP------------------------LNDSGSAGLGVSLK 514
                  A+  + S     ++P                        +   GS GLG ++ 
Sbjct: 342 SSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIV 401

Query: 515 GNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 573
           G +  E     GIF+  I+ GG A   G LR  D++++VNG +L   ++ +A   L+R+
Sbjct: 402 GGEDGE-----GIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRA 455



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 35/79 (44%), Positives = 42/79 (53%), Gaps = 4/79 (5%)

Query: 383 KIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVT 442
           KI L KG  GLGF +V  +    G G IFV  IL  G A   G L+ GDRIL VNG ++ 
Sbjct: 386 KIILHKGSTGLGFNIVGGED---GEG-IFVSFILAGGPADLSGELRRGDRILSVNGVNLR 441

Query: 443 GRTQEELVAMLRSTKQGET 461
             T E+  A L+   Q  T
Sbjct: 442 NATHEQAAAALKRAGQSVT 460



 Score = 31.6 bits (70), Expect = 4.3
 Identities = 21/84 (25%), Positives = 39/84 (46%), Gaps = 6/84 (7%)

Query: 230 GLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLP 289
           G+FI  I     +  +G    N+C++++N VD+ +   ++A +  ++A   P V L V  
Sbjct: 159 GIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEA--GPVVRLVV-- 214

Query: 290 PQNREQYEKSVIGSLNIFGNNDGV 313
              R Q     I  +N+     G+
Sbjct: 215 --RRRQPPPETIMEVNLLKGPKGL 236


>gi|24025688 ligand of numb-protein X 2 [Homo sapiens]
          Length = 690

 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 67/205 (32%), Positives = 97/205 (47%), Gaps = 18/205 (8%)

Query: 384 IDLKKGP-EGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVT 442
           I +KK P E LG TV     S  G  PIFV ++ P G   +DGR++ GD +L +NG D+T
Sbjct: 469 ITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLT 528

Query: 443 GRTQEELVAMLRSTKQGETASLVI--------ARQEGHFLPREL-KGEPDCCA------- 486
             +  E VAML+++      +L          A Q     P    + E D          
Sbjct: 529 NLSHSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMW 588

Query: 487 LSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRM 546
           L L ++     +I L  S     G S+ G    E  T+   FIK+I+ G  A+ DGRL+ 
Sbjct: 589 LGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYE-ENHTNQPFFIKTIVLGTPAYYDGRLKC 647

Query: 547 NDQLIAVNGESLLGKSNHEAMETLR 571
            D ++AVNG S +G S+   +  L+
Sbjct: 648 GDMIVAVNGLSTVGMSHSALVPMLK 672



 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 58/211 (27%), Positives = 96/211 (45%), Gaps = 25/211 (11%)

Query: 381 KIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440
           ++ +  +   E LG  +V R      PG +F+ ++L  G A +DGRL S DR+L +NG D
Sbjct: 339 QVALHKRDSGEQLGIKLVRRTDE---PG-VFILDLLEGGLAAQDGRLSSNDRVLAINGHD 394

Query: 441 VTGRTQEELVAMLRSTKQGETASLVIAR----QEG--------------HFLPRELKGEP 482
           +   T E    +++++  GE  +L IAR    Q G              H  P      P
Sbjct: 395 LKYGTPELAAQIIQAS--GERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRP 452

Query: 483 DCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDG 542
                  +        I +       LG+++ G +  ++G +L IF+ S+   G   +DG
Sbjct: 453 SSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSKSG-ELPIFVTSVPPHGCLARDG 511

Query: 543 RLRMNDQLIAVNGESLLGKSNHEAMETLRRS 573
           R++  D L+ +NG  L   S+ EA+  L+ S
Sbjct: 512 RIKRGDVLLNINGIDLTNLSHSEAVAMLKAS 542



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 46/151 (30%), Positives = 78/151 (51%), Gaps = 17/151 (11%)

Query: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469
           I ++ +   G   +DGRL +GD+IL+VN  +++  +     A+L  ++   T  L + R+
Sbjct: 260 IVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVL--SQPCNTLHLTVLRE 317

Query: 470 EGHFLPRELKGEPDCCALSLETSEQLTFEIPLN--DSGSAGLGVSLKGNKSRETGTDLGI 527
                 R         + S    E++ F++ L+  DSG   LG+ L     R T  + G+
Sbjct: 318 ------RRFGNRAHNHSDSNSPREEI-FQVALHKRDSGEQ-LGIKLV----RRTD-EPGV 364

Query: 528 FIKSIIHGGAAFKDGRLRMNDQLIAVNGESL 558
           FI  ++ GG A +DGRL  ND+++A+NG  L
Sbjct: 365 FILDLLEGGLAAQDGRLSSNDRVLAINGHDL 395



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 58/253 (22%), Positives = 97/253 (38%), Gaps = 48/253 (18%)

Query: 213 LGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQD 272
           LG+ V     S SG  L +F+  +  +    R+G     + ++ IN +DL + + ++A  
Sbjct: 479 LGMTVAGGRGSKSGE-LPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVA 537

Query: 273 VFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTAN 332
           + + +  SP+V L  L  Q  E+  ++     + F  N                      
Sbjct: 538 MLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSEN---------------------- 575

Query: 333 LTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEG 392
                  E DAS S                  PS    +G  S  ++    +  +     
Sbjct: 576 -------EYDASWS------------------PSWVMWLGLPSTLHSCHDIVLRRSYLGS 610

Query: 393 LGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAM 452
            GF++V      H   P F+K I+    A  DGRL+ GD I+ VNG    G +   LV M
Sbjct: 611 WGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPM 670

Query: 453 LRSTKQGETASLV 465
           L+  +   T +++
Sbjct: 671 LKEQRNKVTLTVI 683



 Score = 33.9 bits (76), Expect = 0.87
 Identities = 25/84 (29%), Positives = 39/84 (46%), Gaps = 4/84 (4%)

Query: 487 LSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRM 546
           LSL   E  T EI  ++     LG+S+ G         + I I+ +   G   +DGRL  
Sbjct: 224 LSLPEGEITTIEIHRSNP-YIQLGISIVGGNETPL---INIVIQEVYRDGVIARDGRLLA 279

Query: 547 NDQLIAVNGESLLGKSNHEAMETL 570
            DQ++ VN  ++   S++ A   L
Sbjct: 280 GDQILQVNNYNISNVSHNYARAVL 303


>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
          Length = 926

 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 102/404 (25%), Positives = 164/404 (40%), Gaps = 72/404 (17%)

Query: 380 KKIKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGDRILEVN 437
           K ++I L KGP+GLGF++     + H PG   I+V  I+  GAA KDG+LQ GD++L VN
Sbjct: 316 KIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVN 375

Query: 438 GRDVTGRTQEELVAMLRSTKQGETASLVIARQ----------------------EGHFLP 475
              +   T EE V  L++T   +   L +A+                       + H  P
Sbjct: 376 NVCLEEVTHEEAVTALKNTS--DFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSP 433

Query: 476 RELKGEPDCC-------ALSLETSEQLTFE---IPLNDSGSAGLGVSLKGNKSRETGTDL 525
               G+           + ++   +++T E   + L+  GS GLG ++ G +  E     
Sbjct: 434 SSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLH-RGSTGLGFNIVGGEDGE----- 487

Query: 526 GIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQ 585
           GIFI  I+ GG A   G LR  D++I+VN   L   S+ +A   L+       N    + 
Sbjct: 488 GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALK-------NAGQAVT 540

Query: 586 LVILRRPERPMEDPAECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLL 645
           +V   RPE      A+         E   N+  +S           G+ S +  QK  L 
Sbjct: 541 IVAQYRPEEYSRFEAKIHDLR----EQMMNSSISS-----------GSGSLRTSQKRSLY 585

Query: 646 PNDGWAESEVPPSPTPHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINL 705
               +   +   S  P   L     D  H           D+    R VTP  + + + +
Sbjct: 586 VRALFDYDKTKDSGLPSQGLNFKFGDILHVINASD-----DEWWQARQVTPDGESDEVGV 640

Query: 706 KASKSMDLVPDESKVHSLAGQKSESPSKDFGPTLGLKKSSSLES 749
             SK      + +++ ++   K  S ++D G +   K+  +L S
Sbjct: 641 IPSKRRVEKKERARLKTV---KFNSKTRDKGQSFNDKRKKNLFS 681



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 71/228 (31%), Positives = 111/228 (48%), Gaps = 30/228 (13%)

Query: 353 PRVPRLGGKP---SSPSL-SPLMGFGSNKNAKKIKIDLKKGPEGLGFTVV--TRDSSIHG 406
           P +P+    P   ++ SL +P    G++ + +  +I L++G  GLGF++   T +  I  
Sbjct: 190 PTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGD 249

Query: 407 PGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVI 466
              IF+  I+  GAA +DGRL+  D IL VN  DV   T  + V  L+    G    L +
Sbjct: 250 DSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEA--GSIVRLYV 307

Query: 467 ARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRE-TGTDL 525
            R++                     SE++  EI L   G  GLG S+ G    +    D 
Sbjct: 308 KRRK-------------------PVSEKI-MEIKLI-KGPKGLGFSIAGGVGNQHIPGDN 346

Query: 526 GIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 573
            I++  II GGAA KDG+L++ D+L+AVN   L   ++ EA+  L+ +
Sbjct: 347 SIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNT 394



 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 33/85 (38%), Positives = 50/85 (58%), Gaps = 6/85 (7%)

Query: 493 EQLTFEIPLNDSGSAGLGVSLKGNKSR-ETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLI 551
           E++T E      G++GLG S+ G       G D  IFI  II GGAA +DGRLR+ND ++
Sbjct: 223 EEITLE-----RGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCIL 277

Query: 552 AVNGESLLGKSNHEAMETLRRSMSM 576
            VN   +   ++ +A+E L+ + S+
Sbjct: 278 RVNEVDVRDVTHSKAVEALKEAGSI 302



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 46/152 (30%), Positives = 70/152 (46%), Gaps = 15/152 (9%)

Query: 314 LKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPS-LSPLMG 372
           LK   P  ++   G    ++T + S   D   S           LG  P+SP+  SP+  
Sbjct: 400 LKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSF-------LGQTPASPARYSPVSK 452

Query: 373 --FGSNKNAKKI-KIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQS 429
              G ++  ++  K+ L +G  GLGF +V  +    G G IF+  IL  G A   G L+ 
Sbjct: 453 AVLGDDEITREPRKVVLHRGSTGLGFNIVGGED---GEG-IFISFILAGGPADLSGELRK 508

Query: 430 GDRILEVNGRDVTGRTQEELVAMLRSTKQGET 461
           GDRI+ VN  D+   + E+  A L++  Q  T
Sbjct: 509 GDRIISVNSVDLRAASHEQAAAALKNAGQAVT 540



 Score = 33.9 bits (76), Expect = 0.87
 Identities = 14/47 (29%), Positives = 28/47 (59%)

Query: 231 LFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQA 277
           +FI  I     + ++G    N+CI+++N VD+ D T ++A +  ++A
Sbjct: 253 IFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEA 299


>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
            isoform 3 [Homo sapiens]
          Length = 2294

 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 72/280 (25%), Positives = 121/280 (43%), Gaps = 30/280 (10%)

Query: 315  KTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG 374
            KTK P    G S +   +  G    +    +S Q +++P+        +S  ++    F 
Sbjct: 1112 KTKKP----GISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMN-FKTFS 1166

Query: 375  SN--KNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDR 432
            S+  K     +++L K    LG +V    ++    G I+VK ++P+GAA  DGR+  GDR
Sbjct: 1167 SSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDR 1226

Query: 433  ILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLE-- 490
            +L VNG  + G T ++ V  LR+T  G+   L++ + +       +   P C        
Sbjct: 1227 VLAVNGVSLEGATHKQAVETLRNT--GQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQ 1284

Query: 491  ------------------TSEQLTFEIPL-NDSGSAGLGVSLKGNKSRETGTDLGIFIKS 531
                               +E+ TFE+ L  +S   G   S + N   E      + +K 
Sbjct: 1285 GQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKK 1344

Query: 532  IIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLR 571
            +  G  A + G++ + D ++ VNG SL G S  E +  LR
Sbjct: 1345 LFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALR 1384



 Score = 57.8 bits (138), Expect = 6e-08
 Identities = 95/437 (21%), Positives = 168/437 (38%), Gaps = 81/437 (18%)

Query: 163  LKLVVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFS 222
            L++    S Q+ +D +VL+  +  +++SP  + TL ++ +  +       LG  ++    
Sbjct: 869  LQMRARQSNQDAQDIDVLHK-RWSIVSSPEREITLVNLKKDAKYG-----LGFQIIG--G 920

Query: 223  SLSGRI-LGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQA---- 277
               GR+ LG+FI  +     +  +G     + ++ +N+V L   +   A ++ + A    
Sbjct: 921  EKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDV 980

Query: 278  -----------MKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNND------GVLKTKVPP 320
                        K PS  +H+         + S +    I  ++       G L+     
Sbjct: 981  TLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISEN 1040

Query: 321  PVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSL--SPLMGFGSNKN 378
                  GL+  +L+  DS    AS S  Q        LG +    S   SP     S   
Sbjct: 1041 SFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKAT 1100

Query: 379  AKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNG 438
             K+   D             +  S    PG   V +   +G +  D    S  +      
Sbjct: 1101 EKETFTD-------------SNQSKTKKPGISDVTDYSDRGDSDMDEATYSSSQD----- 1142

Query: 439  RDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFE 498
                             T + E++S V    + +F  +     P       +  +    E
Sbjct: 1143 ---------------HQTPKQESSSSVNTSNKMNF--KTFSSSPP------KPGDIFEVE 1179

Query: 499  IPLNDSGSAGLGVSLKG--NKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGE 556
            +  ND+    LG+S+ G  N S   G   GI++K++I  GAA  DGR+   D+++AVNG 
Sbjct: 1180 LAKNDNS---LGISVTGGVNTSVRHG---GIYVKAVIPQGAAESDGRIHKGDRVLAVNGV 1233

Query: 557  SLLGKSNHEAMETLRRS 573
            SL G ++ +A+ETLR +
Sbjct: 1234 SLEGATHKQAVETLRNT 1250



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 65/311 (20%), Positives = 118/311 (37%), Gaps = 68/311 (21%)

Query: 204  VEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLV 263
            VE++     LGI V    ++ S R  G++++ +     ++ +G  H+ + ++ +N V L 
Sbjct: 1178 VELAKNDNSLGISVTGGVNT-SVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLE 1236

Query: 264  DKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVH 323
              T  QA +  R   +    ++H+L  + +    K  +                   PV 
Sbjct: 1237 GATHKQAVETLRNTGQ----VVHLLLEKGQSPTSKEHV-------------------PVT 1273

Query: 324  GKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIK 383
             +  L   N  G    +   +  ++                        F + +N  ++K
Sbjct: 1274 PQCTLSDQNAQGQGPEKVKKTTQVKD---------------------YSFVTEENTFEVK 1312

Query: 384  IDLKKGPEGLGFTVVTRDSSIH---GPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440
              L K   GLGF+    D+ I        + VK + P   A + G++  GD IL+VNG  
Sbjct: 1313 --LFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1370

Query: 441  VTGRTQEELVAMLRST----------------KQGETASLVIARQEGHFLPRELK--GEP 482
            + G +Q+E+++ LR T                 + +TA L   +     LP   K   +P
Sbjct: 1371 LKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQP 1430

Query: 483  DCCALSLETSE 493
             C   S  + E
Sbjct: 1431 SCVEQSTSSDE 1441



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 73/286 (25%), Positives = 113/286 (39%), Gaps = 37/286 (12%)

Query: 381  KIKIDLKKGPEG-LGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGR 439
            ++ I L K  +G LGFTV   +  I      +V +++ +  A  DGRL+ GDR+++VN  
Sbjct: 1595 ELLITLIKSEKGSLGFTVTKGNQRIG----CYVHDVI-QDPAKSDGRLKPGDRLIKVNDT 1649

Query: 440  DVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEI 499
            DVT  T  + V +LR+    +T  LVI R     LPR            +     L  +I
Sbjct: 1650 DVTNMTHTDAVNLLRAA--SKTVRLVIGRVLE--LPR------------IPMLPHLLPDI 1693

Query: 500  PLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLL 559
             L       LG SL G           ++I  I     A  +G L++ D +  VNG S  
Sbjct: 1694 TLT-CNKEELGFSLCGGHDSLYQV---VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQ 1749

Query: 560  GKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAE---------CGAFSKPCF 610
            G +  E    L  S+           L ++   +R      +          G+ S+P  
Sbjct: 1750 GMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPAL 1809

Query: 611  ENCQNAVTTSRRNDNSILHPLGTCSPQD--KQKGLLLPNDGWAESE 654
                +  T +    N I +P G CS         L LP + + + +
Sbjct: 1810 TPNDSFSTVAGEEINEISYPKGKCSTYQIKGSPNLTLPKESYIQED 1855



 Score = 34.7 bits (78), Expect = 0.51
 Identities = 29/107 (27%), Positives = 49/107 (45%), Gaps = 12/107 (11%)

Query: 490  ETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQ 549
            E   +L   +  ++ GS G  V+ KGN+       +G ++  +I   A   DGRL+  D+
Sbjct: 1591 ELEVELLITLIKSEKGSLGFTVT-KGNQR------IGCYVHDVIQDPAK-SDGRLKPGDR 1642

Query: 550  LIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPM 596
            LI VN   +   ++ +A+  LR +      + G     +L  P  PM
Sbjct: 1643 LIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR----VLELPRIPM 1685



 Score = 33.1 bits (74), Expect = 1.5
 Identities = 35/122 (28%), Positives = 53/122 (43%), Gaps = 22/122 (18%)

Query: 332  NLTGTDSPETDASAS----LQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLK 387
            N+T TD+     +AS    L   +   +PR+   P  P L P +    NK          
Sbjct: 1653 NMTHTDAVNLLRAASKTVRLVIGRVLELPRI---PMLPHLLPDITLTCNK---------- 1699

Query: 388  KGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQE 447
               E LGF++     S++    +++ +I P+  A  +G LQ  D I  VNG    G T E
Sbjct: 1700 ---EELGFSLCGGHDSLYQV--VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLE 1754

Query: 448  EL 449
            E+
Sbjct: 1755 EV 1756


>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
            isoform 1 [Homo sapiens]
          Length = 2485

 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 72/280 (25%), Positives = 121/280 (43%), Gaps = 30/280 (10%)

Query: 315  KTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG 374
            KTK P    G S +   +  G    +    +S Q +++P+        +S  ++    F 
Sbjct: 1303 KTKKP----GISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMN-FKTFS 1357

Query: 375  SN--KNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDR 432
            S+  K     +++L K    LG +V    ++    G I+VK ++P+GAA  DGR+  GDR
Sbjct: 1358 SSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDR 1417

Query: 433  ILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLE-- 490
            +L VNG  + G T ++ V  LR+T  G+   L++ + +       +   P C        
Sbjct: 1418 VLAVNGVSLEGATHKQAVETLRNT--GQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQ 1475

Query: 491  ------------------TSEQLTFEIPL-NDSGSAGLGVSLKGNKSRETGTDLGIFIKS 531
                               +E+ TFE+ L  +S   G   S + N   E      + +K 
Sbjct: 1476 GQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKK 1535

Query: 532  IIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLR 571
            +  G  A + G++ + D ++ VNG SL G S  E +  LR
Sbjct: 1536 LFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALR 1575



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 65/311 (20%), Positives = 118/311 (37%), Gaps = 68/311 (21%)

Query: 204  VEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLV 263
            VE++     LGI V    ++ S R  G++++ +     ++ +G  H+ + ++ +N V L 
Sbjct: 1369 VELAKNDNSLGISVTGGVNT-SVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLE 1427

Query: 264  DKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVH 323
              T  QA +  R   +    ++H+L  + +    K  +                   PV 
Sbjct: 1428 GATHKQAVETLRNTGQ----VVHLLLEKGQSPTSKEHV-------------------PVT 1464

Query: 324  GKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIK 383
             +  L   N  G    +   +  ++                        F + +N  ++K
Sbjct: 1465 PQCTLSDQNAQGQGPEKVKKTTQVKD---------------------YSFVTEENTFEVK 1503

Query: 384  IDLKKGPEGLGFTVVTRDSSIH---GPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440
              L K   GLGF+    D+ I        + VK + P   A + G++  GD IL+VNG  
Sbjct: 1504 --LFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1561

Query: 441  VTGRTQEELVAMLRST----------------KQGETASLVIARQEGHFLPRELK--GEP 482
            + G +Q+E+++ LR T                 + +TA L   +     LP   K   +P
Sbjct: 1562 LKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQP 1621

Query: 483  DCCALSLETSE 493
             C   S  + E
Sbjct: 1622 SCVEQSTSSDE 1632



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 33/79 (41%), Positives = 52/79 (65%), Gaps = 6/79 (7%)

Query: 497  FEIPLNDSGSAGLGVSLKG--NKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVN 554
            FE+ L  + ++ LG+S+ G  N S   G   GI++K++I  GAA  DGR+   D+++AVN
Sbjct: 1367 FEVELAKNDNS-LGISVTGGVNTSVRHG---GIYVKAVIPQGAAESDGRIHKGDRVLAVN 1422

Query: 555  GESLLGKSNHEAMETLRRS 573
            G SL G ++ +A+ETLR +
Sbjct: 1423 GVSLEGATHKQAVETLRNT 1441



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 31/75 (41%), Positives = 42/75 (56%), Gaps = 1/75 (1%)

Query: 499  IPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESL 558
            + L      GLG  + G +      DLGIFI S+  GG A  DG L+  D+LI+VN  SL
Sbjct: 1094 VNLKKDAKYGLGFQIIGGEKMGR-LDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSL 1152

Query: 559  LGKSNHEAMETLRRS 573
             G S+H A+E L+ +
Sbjct: 1153 EGVSHHAAIEILQNA 1167



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 73/286 (25%), Positives = 113/286 (39%), Gaps = 37/286 (12%)

Query: 381  KIKIDLKKGPEG-LGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGR 439
            ++ I L K  +G LGFTV   +  I      +V +++ +  A  DGRL+ GDR+++VN  
Sbjct: 1786 ELLITLIKSEKGSLGFTVTKGNQRIG----CYVHDVI-QDPAKSDGRLKPGDRLIKVNDT 1840

Query: 440  DVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEI 499
            DVT  T  + V +LR+    +T  LVI R     LPR            +     L  +I
Sbjct: 1841 DVTNMTHTDAVNLLRAA--SKTVRLVIGRVLE--LPR------------IPMLPHLLPDI 1884

Query: 500  PLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLL 559
             L       LG SL G           ++I  I     A  +G L++ D +  VNG S  
Sbjct: 1885 TLT-CNKEELGFSLCGGHDSLYQV---VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQ 1940

Query: 560  GKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAE---------CGAFSKPCF 610
            G +  E    L  S+           L ++   +R      +          G+ S+P  
Sbjct: 1941 GMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPAL 2000

Query: 611  ENCQNAVTTSRRNDNSILHPLGTCSPQD--KQKGLLLPNDGWAESE 654
                +  T +    N I +P G CS         L LP + + + +
Sbjct: 2001 TPNDSFSTVAGEEINEISYPKGKCSTYQIKGSPNLTLPKESYIQED 2046



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 26/86 (30%), Positives = 47/86 (54%), Gaps = 3/86 (3%)

Query: 384  IDLKKGPE-GLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVT 442
            ++LKK  + GLGF ++  +        IF+ ++ P G A  DG L+ GDR++ VN   + 
Sbjct: 1094 VNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 1153

Query: 443  GRTQEELVAMLRSTKQGETASLVIAR 468
            G +    + +L++    E  +LVI++
Sbjct: 1154 GVSHHAAIEILQNAP--EDVTLVISQ 1177



 Score = 34.7 bits (78), Expect = 0.51
 Identities = 29/107 (27%), Positives = 49/107 (45%), Gaps = 12/107 (11%)

Query: 490  ETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQ 549
            E   +L   +  ++ GS G  V+ KGN+       +G ++  +I   A   DGRL+  D+
Sbjct: 1782 ELEVELLITLIKSEKGSLGFTVT-KGNQR------IGCYVHDVIQDPAK-SDGRLKPGDR 1833

Query: 550  LIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPM 596
            LI VN   +   ++ +A+  LR +      + G     +L  P  PM
Sbjct: 1834 LIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR----VLELPRIPM 1876



 Score = 33.1 bits (74), Expect = 1.5
 Identities = 35/122 (28%), Positives = 53/122 (43%), Gaps = 22/122 (18%)

Query: 332  NLTGTDSPETDASAS----LQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLK 387
            N+T TD+     +AS    L   +   +PR+   P  P L P +    NK          
Sbjct: 1844 NMTHTDAVNLLRAASKTVRLVIGRVLELPRI---PMLPHLLPDITLTCNK---------- 1890

Query: 388  KGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQE 447
               E LGF++     S++    +++ +I P+  A  +G LQ  D I  VNG    G T E
Sbjct: 1891 ---EELGFSLCGGHDSLYQV--VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLE 1945

Query: 448  EL 449
            E+
Sbjct: 1946 EV 1947


>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
            2 [Homo sapiens]
          Length = 2466

 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 72/280 (25%), Positives = 121/280 (43%), Gaps = 30/280 (10%)

Query: 315  KTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG 374
            KTK P    G S +   +  G    +    +S Q +++P+        +S  ++    F 
Sbjct: 1284 KTKKP----GISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMN-FKTFS 1338

Query: 375  SN--KNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDR 432
            S+  K     +++L K    LG +V    ++    G I+VK ++P+GAA  DGR+  GDR
Sbjct: 1339 SSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDR 1398

Query: 433  ILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLE-- 490
            +L VNG  + G T ++ V  LR+T  G+   L++ + +       +   P C        
Sbjct: 1399 VLAVNGVSLEGATHKQAVETLRNT--GQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQ 1456

Query: 491  ------------------TSEQLTFEIPL-NDSGSAGLGVSLKGNKSRETGTDLGIFIKS 531
                               +E+ TFE+ L  +S   G   S + N   E      + +K 
Sbjct: 1457 GQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKK 1516

Query: 532  IIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLR 571
            +  G  A + G++ + D ++ VNG SL G S  E +  LR
Sbjct: 1517 LFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALR 1556



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 65/311 (20%), Positives = 118/311 (37%), Gaps = 68/311 (21%)

Query: 204  VEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLV 263
            VE++     LGI V    ++ S R  G++++ +     ++ +G  H+ + ++ +N V L 
Sbjct: 1350 VELAKNDNSLGISVTGGVNT-SVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLE 1408

Query: 264  DKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVH 323
              T  QA +  R   +    ++H+L  + +    K  +                   PV 
Sbjct: 1409 GATHKQAVETLRNTGQ----VVHLLLEKGQSPTSKEHV-------------------PVT 1445

Query: 324  GKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIK 383
             +  L   N  G    +   +  ++                        F + +N  ++K
Sbjct: 1446 PQCTLSDQNAQGQGPEKVKKTTQVKD---------------------YSFVTEENTFEVK 1484

Query: 384  IDLKKGPEGLGFTVVTRDSSIH---GPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440
              L K   GLGF+    D+ I        + VK + P   A + G++  GD IL+VNG  
Sbjct: 1485 --LFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1542

Query: 441  VTGRTQEELVAMLRST----------------KQGETASLVIARQEGHFLPRELK--GEP 482
            + G +Q+E+++ LR T                 + +TA L   +     LP   K   +P
Sbjct: 1543 LKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQP 1602

Query: 483  DCCALSLETSE 493
             C   S  + E
Sbjct: 1603 SCVEQSTSSDE 1613



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 33/79 (41%), Positives = 52/79 (65%), Gaps = 6/79 (7%)

Query: 497  FEIPLNDSGSAGLGVSLKG--NKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVN 554
            FE+ L  + ++ LG+S+ G  N S   G   GI++K++I  GAA  DGR+   D+++AVN
Sbjct: 1348 FEVELAKNDNS-LGISVTGGVNTSVRHG---GIYVKAVIPQGAAESDGRIHKGDRVLAVN 1403

Query: 555  GESLLGKSNHEAMETLRRS 573
            G SL G ++ +A+ETLR +
Sbjct: 1404 GVSLEGATHKQAVETLRNT 1422



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 31/75 (41%), Positives = 42/75 (56%), Gaps = 1/75 (1%)

Query: 499  IPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESL 558
            + L      GLG  + G +      DLGIFI S+  GG A  DG L+  D+LI+VN  SL
Sbjct: 1075 VNLKKDAKYGLGFQIIGGEKMGR-LDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSL 1133

Query: 559  LGKSNHEAMETLRRS 573
             G S+H A+E L+ +
Sbjct: 1134 EGVSHHAAIEILQNA 1148



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 73/286 (25%), Positives = 113/286 (39%), Gaps = 37/286 (12%)

Query: 381  KIKIDLKKGPEG-LGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGR 439
            ++ I L K  +G LGFTV   +  I      +V +++ +  A  DGRL+ GDR+++VN  
Sbjct: 1767 ELLITLIKSEKGSLGFTVTKGNQRIG----CYVHDVI-QDPAKSDGRLKPGDRLIKVNDT 1821

Query: 440  DVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEI 499
            DVT  T  + V +LR+    +T  LVI R     LPR            +     L  +I
Sbjct: 1822 DVTNMTHTDAVNLLRAA--SKTVRLVIGRVLE--LPR------------IPMLPHLLPDI 1865

Query: 500  PLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLL 559
             L       LG SL G           ++I  I     A  +G L++ D +  VNG S  
Sbjct: 1866 TLT-CNKEELGFSLCGGHDSLYQV---VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQ 1921

Query: 560  GKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAE---------CGAFSKPCF 610
            G +  E    L  S+           L ++   +R      +          G+ S+P  
Sbjct: 1922 GMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPAL 1981

Query: 611  ENCQNAVTTSRRNDNSILHPLGTCSPQD--KQKGLLLPNDGWAESE 654
                +  T +    N I +P G CS         L LP + + + +
Sbjct: 1982 TPNDSFSTVAGEEINEISYPKGKCSTYQIKGSPNLTLPKESYIQED 2027



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 26/86 (30%), Positives = 47/86 (54%), Gaps = 3/86 (3%)

Query: 384  IDLKKGPE-GLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVT 442
            ++LKK  + GLGF ++  +        IF+ ++ P G A  DG L+ GDR++ VN   + 
Sbjct: 1075 VNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 1134

Query: 443  GRTQEELVAMLRSTKQGETASLVIAR 468
            G +    + +L++    E  +LVI++
Sbjct: 1135 GVSHHAAIEILQNAP--EDVTLVISQ 1158



 Score = 34.7 bits (78), Expect = 0.51
 Identities = 29/107 (27%), Positives = 49/107 (45%), Gaps = 12/107 (11%)

Query: 490  ETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQ 549
            E   +L   +  ++ GS G  V+ KGN+       +G ++  +I   A   DGRL+  D+
Sbjct: 1763 ELEVELLITLIKSEKGSLGFTVT-KGNQR------IGCYVHDVIQDPAK-SDGRLKPGDR 1814

Query: 550  LIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPM 596
            LI VN   +   ++ +A+  LR +      + G     +L  P  PM
Sbjct: 1815 LIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR----VLELPRIPM 1857



 Score = 33.1 bits (74), Expect = 1.5
 Identities = 35/122 (28%), Positives = 53/122 (43%), Gaps = 22/122 (18%)

Query: 332  NLTGTDSPETDASAS----LQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLK 387
            N+T TD+     +AS    L   +   +PR+   P  P L P +    NK          
Sbjct: 1825 NMTHTDAVNLLRAASKTVRLVIGRVLELPRI---PMLPHLLPDITLTCNK---------- 1871

Query: 388  KGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQE 447
               E LGF++     S++    +++ +I P+  A  +G LQ  D I  VNG    G T E
Sbjct: 1872 ---EELGFSLCGGHDSLYQV--VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLE 1926

Query: 448  EL 449
            E+
Sbjct: 1927 EV 1928


>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
          Length = 904

 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 71/228 (31%), Positives = 111/228 (48%), Gaps = 30/228 (13%)

Query: 353 PRVPRLGGKP---SSPSL-SPLMGFGSNKNAKKIKIDLKKGPEGLGFTVV--TRDSSIHG 406
           P +P+    P   ++ SL +P    G++ + +  +I L++G  GLGF++   T +  I  
Sbjct: 190 PTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGD 249

Query: 407 PGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVI 466
              IF+  I+  GAA +DGRL+  D IL VN  DV   T  + V  L+    G    L +
Sbjct: 250 DSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEA--GSIVRLYV 307

Query: 467 ARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRE-TGTDL 525
            R++                     SE++  EI L   G  GLG S+ G    +    D 
Sbjct: 308 KRRK-------------------PVSEKI-MEIKLI-KGPKGLGFSIAGGVGNQHIPGDN 346

Query: 526 GIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 573
            I++  II GGAA KDG+L++ D+L+AVN   L   ++ EA+  L+ +
Sbjct: 347 SIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNT 394



 Score = 81.3 bits (199), Expect = 5e-15
 Identities = 83/304 (27%), Positives = 130/304 (42%), Gaps = 49/304 (16%)

Query: 380 KKIKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGDRILEVN 437
           K ++I L KGP+GLGF++     + H PG   I+V  I+  GAA KDG+LQ GD++L VN
Sbjct: 316 KIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVN 375

Query: 438 GRDVTGRTQEELVAMLRSTKQGETASLVIARQ----------------------EGHFLP 475
              +   T EE V  L++T   +   L +A+                       + H  P
Sbjct: 376 NVCLEEVTHEEAVTALKNTS--DFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSP 433

Query: 476 RELKGEPDCC-------ALSLETSEQLTFE---IPLNDSGSAGLGVSLKGNKSRETGTDL 525
               G+           + ++   +++T E   + L+  GS GLG ++ G +  E     
Sbjct: 434 SSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLH-RGSTGLGFNIVGGEDGE----- 487

Query: 526 GIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQ 585
           GIFI  I+ GG A   G LR  D++I+VN   L   S+ +A   L+       N    + 
Sbjct: 488 GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALK-------NAGQAVT 540

Query: 586 LVILRRPERPMEDPAECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLL 645
           +V   RPE      A+     +    +  ++ + S R        +      DK K   L
Sbjct: 541 IVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGL 600

Query: 646 PNDG 649
           P+ G
Sbjct: 601 PSQG 604



 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 33/85 (38%), Positives = 50/85 (58%), Gaps = 6/85 (7%)

Query: 493 EQLTFEIPLNDSGSAGLGVSLKGNKSR-ETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLI 551
           E++T E      G++GLG S+ G       G D  IFI  II GGAA +DGRLR+ND ++
Sbjct: 223 EEITLE-----RGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCIL 277

Query: 552 AVNGESLLGKSNHEAMETLRRSMSM 576
            VN   +   ++ +A+E L+ + S+
Sbjct: 278 RVNEVDVRDVTHSKAVEALKEAGSI 302



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 46/152 (30%), Positives = 70/152 (46%), Gaps = 15/152 (9%)

Query: 314 LKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPS-LSPLMG 372
           LK   P  ++   G    ++T + S   D   S           LG  P+SP+  SP+  
Sbjct: 400 LKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSF-------LGQTPASPARYSPVSK 452

Query: 373 --FGSNKNAKKI-KIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQS 429
              G ++  ++  K+ L +G  GLGF +V  +    G G IF+  IL  G A   G L+ 
Sbjct: 453 AVLGDDEITREPRKVVLHRGSTGLGFNIVGGED---GEG-IFISFILAGGPADLSGELRK 508

Query: 430 GDRILEVNGRDVTGRTQEELVAMLRSTKQGET 461
           GDRI+ VN  D+   + E+  A L++  Q  T
Sbjct: 509 GDRIISVNSVDLRAASHEQAAAALKNAGQAVT 540



 Score = 33.9 bits (76), Expect = 0.87
 Identities = 14/47 (29%), Positives = 28/47 (59%)

Query: 231 LFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQA 277
           +FI  I     + ++G    N+CI+++N VD+ D T ++A +  ++A
Sbjct: 253 IFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEA 299


>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
           sapiens]
          Length = 767

 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 72/237 (30%), Positives = 105/237 (44%), Gaps = 54/237 (22%)

Query: 380 KKIKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGDRILEVN 437
           K ++I L KGP+GLGF++     + H PG   I+V  I+  GAA KDGRLQ GD+IL VN
Sbjct: 200 KVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVN 259

Query: 438 GRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTF 497
              +     E+ VA L++T   +   L +A+    +L  +    PD   ++   S+ L  
Sbjct: 260 SVGLEDVMHEDAVAALKNTY--DVVYLKVAKPSNAYL-SDSYAPPD---ITTSYSQHLDN 313

Query: 498 EIPLND-----------------------------------------SGSAGLGVSLKGN 516
           EI  +                                           GS GLG ++ G 
Sbjct: 314 EISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGG 373

Query: 517 KSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 573
           +  E     GIFI  I+ GG A   G LR  DQ+++VNG  L   S+ +A   L+ +
Sbjct: 374 EDGE-----GIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNA 425



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 63/194 (32%), Positives = 92/194 (47%), Gaps = 26/194 (13%)

Query: 383 KIDLKKGPEGLGFTVVTRDSSIH-GPGP-IFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440
           +I L++G  GLGF++     + H G  P IF+  I+P GAA +DGRL+  D IL VN  D
Sbjct: 108 EITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVD 167

Query: 441 VTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIP 500
           V   T    V  L+    G    L + R++                       +   EI 
Sbjct: 168 VREVTHSAAVEALKEA--GSIVRLYVMRRK--------------------PPAEKVMEIK 205

Query: 501 LNDSGSAGLGVSLKGNKSRE-TGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLL 559
           L   G  GLG S+ G    +    D  I++  II GGAA KDGRL++ D+++AVN   L 
Sbjct: 206 LI-KGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLE 264

Query: 560 GKSNHEAMETLRRS 573
              + +A+  L+ +
Sbjct: 265 DVMHEDAVAALKNT 278



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 35/102 (34%), Positives = 57/102 (55%), Gaps = 8/102 (7%)

Query: 491 TSEQLTFEIPLNDSGSAGLGVSLKGNKSR-ETGTDLGIFIKSIIHGGAAFKDGRLRMNDQ 549
           T  ++ +E    + G++GLG S+ G       G D  IFI  II GGAA +DGRLR+ND 
Sbjct: 100 TEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDS 159

Query: 550 LIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRR 591
           ++ VN   +   ++  A+E L+ + S       +++L ++RR
Sbjct: 160 ILFVNEVDVREVTHSAAVEALKEAGS-------IVRLYVMRR 194



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 102/441 (23%), Positives = 161/441 (36%), Gaps = 79/441 (17%)

Query: 58  ILDPDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFK- 116
           +LD  D     + +  K     E+  PL    SP+  P    SP         +   ++ 
Sbjct: 38  LLDILDYYEASLSESQKYRYQDEDTPPLE--HSPAHLPNQANSPPVIVNTDTLEAPGYEL 95

Query: 117 ---PIGGEIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASH----PGG---QSLKLV 166
                 GE+E     L+ G   L    +     P     PS       PGG   Q  +L 
Sbjct: 96  QVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLR 155

Query: 167 VPDS---TQNLEDREVLNGVQTELLTSPRTKDTLSDMTR------TVEISGEGGPLGIHV 217
           V DS      ++ REV +    E L    +   L  M R       +EI    GP G+  
Sbjct: 156 VNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLG- 214

Query: 218 VPFFSSLSG----RILG---LFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQA 270
              FS   G     I G   +++  I +   + ++G     + I+ +N+V L D     A
Sbjct: 215 ---FSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDA 271

Query: 271 QDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPV------HG 324
               +       V L V  P N    +                  +  PP +      H 
Sbjct: 272 VAALKNTYDV--VYLKVAKPSNAYLSD------------------SYAPPDITTSYSQHL 311

Query: 325 KSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKI 384
            + +  ++  GTD P T  + +  +  SP    L G+   P              +  +I
Sbjct: 312 DNEISHSSYLGTDYP-TAMTPTSPRRYSPVAKDLLGEEDIPR-------------EPRRI 357

Query: 385 DLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGR 444
            + +G  GLGF +V  +    G G IF+  IL  G A   G L+ GD+IL VNG D+   
Sbjct: 358 VIHRGSTGLGFNIVGGED---GEG-IFISFILAGGPADLSGELRKGDQILSVNGVDLRNA 413

Query: 445 TQEELVAMLRSTKQGETASLV 465
           + E+    L++   G+T +++
Sbjct: 414 SHEQAAIALKNA--GQTVTII 432


>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
           sapiens]
          Length = 721

 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 72/237 (30%), Positives = 105/237 (44%), Gaps = 54/237 (22%)

Query: 380 KKIKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGDRILEVN 437
           K ++I L KGP+GLGF++     + H PG   I+V  I+  GAA KDGRLQ GD+IL VN
Sbjct: 154 KVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVN 213

Query: 438 GRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTF 497
              +     E+ VA L++T   +   L +A+    +L  +    PD   ++   S+ L  
Sbjct: 214 SVGLEDVMHEDAVAALKNTY--DVVYLKVAKPSNAYL-SDSYAPPD---ITTSYSQHLDN 267

Query: 498 EIPLND-----------------------------------------SGSAGLGVSLKGN 516
           EI  +                                           GS GLG ++ G 
Sbjct: 268 EISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGG 327

Query: 517 KSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 573
           +  E     GIFI  I+ GG A   G LR  DQ+++VNG  L   S+ +A   L+ +
Sbjct: 328 EDGE-----GIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNA 379



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 63/194 (32%), Positives = 92/194 (47%), Gaps = 26/194 (13%)

Query: 383 KIDLKKGPEGLGFTVVTRDSSIH-GPGP-IFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440
           +I L++G  GLGF++     + H G  P IF+  I+P GAA +DGRL+  D IL VN  D
Sbjct: 62  EITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVD 121

Query: 441 VTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIP 500
           V   T    V  L+    G    L + R++                       +   EI 
Sbjct: 122 VREVTHSAAVEALKEA--GSIVRLYVMRRK--------------------PPAEKVMEIK 159

Query: 501 LNDSGSAGLGVSLKGNKSRE-TGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLL 559
           L   G  GLG S+ G    +    D  I++  II GGAA KDGRL++ D+++AVN   L 
Sbjct: 160 LI-KGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLE 218

Query: 560 GKSNHEAMETLRRS 573
              + +A+  L+ +
Sbjct: 219 DVMHEDAVAALKNT 232



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 35/102 (34%), Positives = 57/102 (55%), Gaps = 8/102 (7%)

Query: 491 TSEQLTFEIPLNDSGSAGLGVSLKGNKSR-ETGTDLGIFIKSIIHGGAAFKDGRLRMNDQ 549
           T  ++ +E    + G++GLG S+ G       G D  IFI  II GGAA +DGRLR+ND 
Sbjct: 54  TEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDS 113

Query: 550 LIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRR 591
           ++ VN   +   ++  A+E L+ + S       +++L ++RR
Sbjct: 114 ILFVNEVDVREVTHSAAVEALKEAGS-------IVRLYVMRR 148



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 99/416 (23%), Positives = 153/416 (36%), Gaps = 76/416 (18%)

Query: 80  EEQEPLHKIESPSGNPADRQSPDAF-ETEVAAQLAAFKPIGGEIEVTPSALKLGTPLLVR 138
           E+  PL    SP+  P    SP     T+            GE+E     L+ G   L  
Sbjct: 17  EDTPPLE--HSPAHLPNQANSPPVIVNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGF 74

Query: 139 RSSDPVPGPPADTQPSASH----PGG---QSLKLVVPDS---TQNLEDREVLNGVQTELL 188
             +     P     PS       PGG   Q  +L V DS      ++ REV +    E L
Sbjct: 75  SIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEAL 134

Query: 189 TSPRTKDTLSDMTR------TVEISGEGGPLGIHVVPFFSSLSG----RILG---LFIRG 235
               +   L  M R       +EI    GP G+     FS   G     I G   +++  
Sbjct: 135 KEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLG----FSIAGGVGNQHIPGDNSIYVTK 190

Query: 236 IEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQ 295
           I +   + ++G     + I+ +N+V L D     A    +       V L V  P N   
Sbjct: 191 IIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDV--VYLKVAKPSNAYL 248

Query: 296 YEKSVIGSLNIFGNNDGVLKTKVPPPV------HGKSGLKTANLTGTDSPETDASASLQQ 349
            +                  +  PP +      H  + +  ++  GTD P T  + +  +
Sbjct: 249 SD------------------SYAPPDITTSYSQHLDNEISHSSYLGTDYP-TAMTPTSPR 289

Query: 350 NKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGP 409
             SP    L G+   P              +  +I + +G  GLGF +V  +    G G 
Sbjct: 290 RYSPVAKDLLGEEDIPR-------------EPRRIVIHRGSTGLGFNIVGGED---GEG- 332

Query: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLV 465
           IF+  IL  G A   G L+ GD+IL VNG D+   + E+    L++   G+T +++
Sbjct: 333 IFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNA--GQTVTII 386


>gi|148833504 interleukin 16 isoform 2 [Homo sapiens]
          Length = 1332

 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 59/192 (30%), Positives = 90/192 (46%), Gaps = 25/192 (13%)

Query: 386 LKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRT 445
           +K   +GLGF++V    SI+GP  I+VK I   GAA  DGRLQ GD ILE+NG  + G T
Sbjct: 220 MKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLT 279

Query: 446 QEELVAMLRSTKQGETASLVIARQE------GHFLP---RELKGE----PDCCALSLET- 491
            ++ +   +  K+G     V  R         H  P   R L        D  + +LE+ 
Sbjct: 280 HQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESP 339

Query: 492 ---------SEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDG 542
                    + ++  E+ L      GLG+ L      +  +  GIF+ ++  G  A  DG
Sbjct: 340 SAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCIS--GIFVHTLSPGSVAHLDG 397

Query: 543 RLRMNDQLIAVN 554
           RLR  D+++ ++
Sbjct: 398 RLRCGDEIVEIS 409



 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 51/198 (25%), Positives = 94/198 (47%), Gaps = 15/198 (7%)

Query: 410  IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469
            I V  + P G A ++G +Q G+ +L +NG+ + G T  + +A+LR  ++   A +V  + 
Sbjct: 1139 ITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKL 1198

Query: 470  EGHFLPRELKGEPDCCA-------LSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETG 522
                +P +L    D  A       +S+E++ + T      +  SAGLG SL+G K    G
Sbjct: 1199 TPEAMP-DLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHG 1257

Query: 523  TDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRG 582
             D  + I  I  G A+ +   ++  D+++ + G ++ G +  EA   ++          G
Sbjct: 1258 -DKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPD------G 1310

Query: 583  MIQLVILRRPERPMEDPA 600
             + +VI R+  +  E  A
Sbjct: 1311 PVTIVIRRKSLQSKETTA 1328



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 40/142 (28%), Positives = 73/142 (51%), Gaps = 14/142 (9%)

Query: 499 IPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESL 558
           I L    + GLG S+ G K    G  +GI++K+I  GGAA  DGRL+  D+++ +NGES+
Sbjct: 217 IVLMKGQAKGLGFSIVGGKDSIYGP-IGIYVKTIFAGGAAAADGRLQEGDEILELNGESM 275

Query: 559 LGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKPCFENCQNAVT 618
            G ++ +A++  +++       +G++ L +  R   P   P+ C   S P   +  ++  
Sbjct: 276 AGLTHQDALQKFKQAK------KGLLTLTVRTRLTAP---PSLCSHLSPPLCRSLSSSTC 326

Query: 619 TSRRNDNSILH----PLGTCSP 636
            ++ + +  L     P+ T  P
Sbjct: 327 ITKDSSSFALESPSAPISTAKP 348



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 36/144 (25%), Positives = 63/144 (43%), Gaps = 17/144 (11%)

Query: 342  DASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG----------------SNKNAKKIKID 385
            DA A L+Q + PR   +  +  +P   P +                   S   A    + 
Sbjct: 1177 DALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVT 1236

Query: 386  LKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRT 445
            L+K   GLGF++     S+HG  P+ +  I    A+ +   +Q GD IL++ G  + G T
Sbjct: 1237 LEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLT 1296

Query: 446  QEELVAMLRSTKQGETASLVIARQ 469
            + E   ++++   G   ++VI R+
Sbjct: 1297 RFEAWNIIKALPDG-PVTIVIRRK 1319



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 67/300 (22%), Positives = 114/300 (38%), Gaps = 48/300 (16%)

Query: 183 VQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRS 242
           + T  L  P      S ++  V + G+   LG  +V    S+ G I G++++ I     +
Sbjct: 197 LSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPI-GIYVKTIFAGGAA 255

Query: 243 KREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIG 302
             +G   E + I+++N   +   T   A   F+QA K     L  L  + R     S+  
Sbjct: 256 AADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKG----LLTLTVRTRLTAPPSLCS 311

Query: 303 SLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKP 362
            L+              PP+         +L+ +     D+S+   +  SP  P    KP
Sbjct: 312 HLS--------------PPL-------CRSLSSSTCITKDSSSFALE--SPSAPISTAKP 348

Query: 363 SSPSLSPLMGFGSNKNAKKIKIDLKKGPE---GLGFTVVTRDSSIHGPGPIFVKNILPKG 419
           +   +              +++ L+K      G+G   V     I G   IFV  + P  
Sbjct: 349 NYRIM--------------VEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGS 391

Query: 420 AAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELK 479
            A  DGRL+ GD I+E++   V   T  E+  +L     G    +V    +     ++LK
Sbjct: 392 VAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLK 451


>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
          Length = 749

 Score = 80.9 bits (198), Expect = 6e-15
 Identities = 67/194 (34%), Positives = 96/194 (49%), Gaps = 26/194 (13%)

Query: 383 KIDLKKGPEGLGFTVVTRDSSIH-GPGP-IFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440
           +I L++G  GLGF++     + H G  P IF+  I+P GAA +DGRL+  D IL VN  D
Sbjct: 47  EITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVD 106

Query: 441 VTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIP 500
           V+  +  + V  L+    G    L + R+                   LET      EI 
Sbjct: 107 VSEVSHSKAVEALKEA--GSIVRLYVRRRRP----------------ILET----VVEIK 144

Query: 501 LNDSGSAGLGVSLKGNKSRE-TGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLL 559
           L   G  GLG S+ G    +    D  I++  II GGAA KDGRL++ D+L+ VN  SL 
Sbjct: 145 LF-KGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLE 203

Query: 560 GKSNHEAMETLRRS 573
             ++ EA+  L+ +
Sbjct: 204 EVTHEEAVAILKNT 217



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 37/79 (46%), Positives = 51/79 (64%), Gaps = 2/79 (2%)

Query: 382 IKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGDRILEVNGR 439
           ++I L KGP+GLGF++     + H PG   I+V  I+  GAA KDGRLQ GDR+L VN  
Sbjct: 141 VEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNY 200

Query: 440 DVTGRTQEELVAMLRSTKQ 458
            +   T EE VA+L++T +
Sbjct: 201 SLEEVTHEEAVAILKNTSE 219



 Score = 63.9 bits (154), Expect = 8e-10
 Identities = 76/301 (25%), Positives = 126/301 (41%), Gaps = 49/301 (16%)

Query: 231 LFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMK-------SPSV 283
           +++  I D   ++++G     + ++ +NN  L + T  +A  + +   +        P+ 
Sbjct: 171 IYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTT 230

Query: 284 LLHVLP---PQNREQYEKSVIGSLNIFGNNDGVL--KTKVPPPVHGKSGLKTANLTGTDS 338
           +    P   P     Y   +   L     N+G L  KT +PP   G+      ++   D 
Sbjct: 231 IYMTDPYGPPDITHSYSPPMENHL--LSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDD- 287

Query: 339 PETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVV 398
              D ++  Q + + R P           S  +    +   +  K+ L KG  GLGF +V
Sbjct: 288 ---DYTSHSQHSTATRQP-----------SMTLQRAVSLEGEPRKVVLHKGSTGLGFNIV 333

Query: 399 TRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQ 458
             +    G G IFV  IL  G A   G LQ GD+IL VNG D+ G + E+  A L+    
Sbjct: 334 GGED---GEG-IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA-- 387

Query: 459 GETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKS 518
           G+T +++   Q   +   E K          +  EQ+     +N S S+G G SL+ N+ 
Sbjct: 388 GQTVTIIAQYQPEDYARFEAKIH--------DLREQM-----MNHSMSSGSG-SLRTNQK 433

Query: 519 R 519
           R
Sbjct: 434 R 434



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 42/119 (35%), Positives = 60/119 (50%), Gaps = 9/119 (7%)

Query: 491 TSEQLTFEIPLNDSGSAGLGVSLKGNKSR-ETGTDLGIFIKSIIHGGAAFKDGRLRMNDQ 549
           T  +  FE    + G++GLG S+ G       G D GIFI  II GGAA +DGRLR+ND 
Sbjct: 39  TEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDC 98

Query: 550 LIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKP 608
           ++ VN   +   S+ +A+E L+ +        G I  + +RR    +E   E   F  P
Sbjct: 99  ILRVNEVDVSEVSHSKAVEALKEA--------GSIVRLYVRRRRPILETVVEIKLFKGP 149



 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 26/67 (38%), Positives = 38/67 (56%), Gaps = 5/67 (7%)

Query: 505 GSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNH 564
           GS GLG ++ G +  E     GIF+  I+ GG A   G L+  DQ+++VNG  L G S+ 
Sbjct: 324 GSTGLGFNIVGGEDGE-----GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHE 378

Query: 565 EAMETLR 571
           +A   L+
Sbjct: 379 QAAAALK 385



 Score = 33.1 bits (74), Expect = 1.5
 Identities = 13/48 (27%), Positives = 28/48 (58%)

Query: 230 GLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQA 277
           G+FI  I     +  +G    N+CI+++N VD+ + + ++A +  ++A
Sbjct: 75  GIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEA 122


>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
          Length = 975

 Score = 80.9 bits (198), Expect = 6e-15
 Identities = 67/194 (34%), Positives = 96/194 (49%), Gaps = 26/194 (13%)

Query: 383 KIDLKKGPEGLGFTVVTRDSSIH-GPGP-IFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440
           +I L++G  GLGF++     + H G  P IF+  I+P GAA +DGRL+  D IL VN  D
Sbjct: 203 EITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVD 262

Query: 441 VTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIP 500
           V+  +  + V  L+    G    L + R+                   LET      EI 
Sbjct: 263 VSEVSHSKAVEALKEA--GSIVRLYVRRRRP----------------ILET----VVEIK 300

Query: 501 LNDSGSAGLGVSLKGNKSRE-TGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLL 559
           L   G  GLG S+ G    +    D  I++  II GGAA KDGRL++ D+L+ VN  SL 
Sbjct: 301 LF-KGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLE 359

Query: 560 GKSNHEAMETLRRS 573
             ++ EA+  L+ +
Sbjct: 360 EVTHEEAVAILKNT 373



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 37/79 (46%), Positives = 51/79 (64%), Gaps = 2/79 (2%)

Query: 382 IKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGDRILEVNGR 439
           ++I L KGP+GLGF++     + H PG   I+V  I+  GAA KDGRLQ GDR+L VN  
Sbjct: 297 VEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNY 356

Query: 440 DVTGRTQEELVAMLRSTKQ 458
            +   T EE VA+L++T +
Sbjct: 357 SLEEVTHEEAVAILKNTSE 375



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 42/119 (35%), Positives = 60/119 (50%), Gaps = 9/119 (7%)

Query: 491 TSEQLTFEIPLNDSGSAGLGVSLKGNKSR-ETGTDLGIFIKSIIHGGAAFKDGRLRMNDQ 549
           T  +  FE    + G++GLG S+ G       G D GIFI  II GGAA +DGRLR+ND 
Sbjct: 195 TEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDC 254

Query: 550 LIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKP 608
           ++ VN   +   S+ +A+E L+ +        G I  + +RR    +E   E   F  P
Sbjct: 255 ILRVNEVDVSEVSHSKAVEALKEA--------GSIVRLYVRRRRPILETVVEIKLFKGP 305



 Score = 57.4 bits (137), Expect = 7e-08
 Identities = 49/137 (35%), Positives = 68/137 (49%), Gaps = 20/137 (14%)

Query: 383 KIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVT 442
           K+ L KG  GLGF +V  +    G G IFV  IL  G A   G LQ GD+IL VNG D+ 
Sbjct: 526 KVVLHKGSTGLGFNIVGGED---GEG-IFVSFILAGGPADLSGELQRGDQILSVNGIDLR 581

Query: 443 GRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLN 502
           G + E+  A L+    G+T +++   Q   +   E K          +  EQ+     +N
Sbjct: 582 GASHEQAAAALKGA--GQTVTIIAQYQPEDYARFEAKIH--------DLREQM-----MN 626

Query: 503 DSGSAGLGVSLKGNKSR 519
            S S+G G SL+ N+ R
Sbjct: 627 HSMSSGSG-SLRTNQKR 642



 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 26/67 (38%), Positives = 38/67 (56%), Gaps = 5/67 (7%)

Query: 505 GSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNH 564
           GS GLG ++ G +  E     GIF+  I+ GG A   G L+  DQ+++VNG  L G S+ 
Sbjct: 532 GSTGLGFNIVGGEDGE-----GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHE 586

Query: 565 EAMETLR 571
           +A   L+
Sbjct: 587 QAAAALK 593



 Score = 33.1 bits (74), Expect = 1.5
 Identities = 13/48 (27%), Positives = 28/48 (58%)

Query: 230 GLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQA 277
           G+FI  I     +  +G    N+CI+++N VD+ + + ++A +  ++A
Sbjct: 231 GIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEA 278


>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
          Length = 870

 Score = 80.9 bits (198), Expect = 6e-15
 Identities = 67/194 (34%), Positives = 96/194 (49%), Gaps = 26/194 (13%)

Query: 383 KIDLKKGPEGLGFTVVTRDSSIH-GPGP-IFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440
           +I L++G  GLGF++     + H G  P IF+  I+P GAA +DGRL+  D IL VN  D
Sbjct: 98  EITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVD 157

Query: 441 VTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIP 500
           V+  +  + V  L+    G    L + R+                   LET      EI 
Sbjct: 158 VSEVSHSKAVEALKEA--GSIVRLYVRRRRP----------------ILET----VVEIK 195

Query: 501 LNDSGSAGLGVSLKGNKSRE-TGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLL 559
           L   G  GLG S+ G    +    D  I++  II GGAA KDGRL++ D+L+ VN  SL 
Sbjct: 196 LF-KGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLE 254

Query: 560 GKSNHEAMETLRRS 573
             ++ EA+  L+ +
Sbjct: 255 EVTHEEAVAILKNT 268



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 37/79 (46%), Positives = 51/79 (64%), Gaps = 2/79 (2%)

Query: 382 IKIDLKKGPEGLGFTVVTRDSSIHGPGP--IFVKNILPKGAAIKDGRLQSGDRILEVNGR 439
           ++I L KGP+GLGF++     + H PG   I+V  I+  GAA KDGRLQ GDR+L VN  
Sbjct: 192 VEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNY 251

Query: 440 DVTGRTQEELVAMLRSTKQ 458
            +   T EE VA+L++T +
Sbjct: 252 SLEEVTHEEAVAILKNTSE 270



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 42/119 (35%), Positives = 60/119 (50%), Gaps = 9/119 (7%)

Query: 491 TSEQLTFEIPLNDSGSAGLGVSLKGNKSR-ETGTDLGIFIKSIIHGGAAFKDGRLRMNDQ 549
           T  +  FE    + G++GLG S+ G       G D GIFI  II GGAA +DGRLR+ND 
Sbjct: 90  TEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDC 149

Query: 550 LIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKP 608
           ++ VN   +   S+ +A+E L+ +        G I  + +RR    +E   E   F  P
Sbjct: 150 ILRVNEVDVSEVSHSKAVEALKEA--------GSIVRLYVRRRRPILETVVEIKLFKGP 200



 Score = 57.4 bits (137), Expect = 7e-08
 Identities = 49/137 (35%), Positives = 68/137 (49%), Gaps = 20/137 (14%)

Query: 383 KIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVT 442
           K+ L KG  GLGF +V  +    G G IFV  IL  G A   G LQ GD+IL VNG D+ 
Sbjct: 421 KVVLHKGSTGLGFNIVGGED---GEG-IFVSFILAGGPADLSGELQRGDQILSVNGIDLR 476

Query: 443 GRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLN 502
           G + E+  A L+    G+T +++   Q   +   E K          +  EQ+     +N
Sbjct: 477 GASHEQAAAALKGA--GQTVTIIAQYQPEDYARFEAKIH--------DLREQM-----MN 521

Query: 503 DSGSAGLGVSLKGNKSR 519
            S S+G G SL+ N+ R
Sbjct: 522 HSMSSGSG-SLRTNQKR 537



 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 26/67 (38%), Positives = 38/67 (56%), Gaps = 5/67 (7%)

Query: 505 GSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNH 564
           GS GLG ++ G +  E     GIF+  I+ GG A   G L+  DQ+++VNG  L G S+ 
Sbjct: 427 GSTGLGFNIVGGEDGE-----GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHE 481

Query: 565 EAMETLR 571
           +A   L+
Sbjct: 482 QAAAALK 488



 Score = 33.1 bits (74), Expect = 1.5
 Identities = 13/48 (27%), Positives = 28/48 (58%)

Query: 230 GLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQA 277
           G+FI  I     +  +G    N+CI+++N VD+ + + ++A +  ++A
Sbjct: 126 GIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEA 173


>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
            isoform 4 [Homo sapiens]
          Length = 2490

 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 63/255 (24%), Positives = 107/255 (41%), Gaps = 31/255 (12%)

Query: 338  SPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTV 397
            +P+ ++S+S+  +           P  P     +    N N+  I + +     G+  +V
Sbjct: 1336 TPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTVLFDKGGVNTSV 1395

Query: 398  VTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTK 457
                      G I+VK ++P+GAA  DGR+  GDR+L VNG  + G T ++ V  LR+T 
Sbjct: 1396 --------RHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNT- 1446

Query: 458  QGETASLVIARQEGHFLPRELKGEPDCCALSLE--------------------TSEQLTF 497
             G+   L++ + +       +   P C                           +E+ TF
Sbjct: 1447 -GQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTF 1505

Query: 498  EIPL-NDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGE 556
            E+ L  +S   G   S + N   E      + +K +  G  A + G++ + D ++ VNG 
Sbjct: 1506 EVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGA 1565

Query: 557  SLLGKSNHEAMETLR 571
            SL G S  E +  LR
Sbjct: 1566 SLKGLSQQEVISALR 1580



 Score = 57.4 bits (137), Expect = 7e-08
 Identities = 66/315 (20%), Positives = 118/315 (37%), Gaps = 71/315 (22%)

Query: 204  VEISGEGGPLGIHVVPFFS----SLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINN 259
            VE++     LGI V   F     + S R  G++++ +     ++ +G  H+ + ++ +N 
Sbjct: 1369 VELAKNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNG 1428

Query: 260  VDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVP 319
            V L   T  QA +  R   +    ++H+L  + +    K  +                  
Sbjct: 1429 VSLEGATHKQAVETLRNTGQ----VVHLLLEKGQSPTSKEHV------------------ 1466

Query: 320  PPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNA 379
             PV  +  L   N  G    +   +  ++                        F + +N 
Sbjct: 1467 -PVTPQCTLSDQNAQGQGPEKVKKTTQVKD---------------------YSFVTEENT 1504

Query: 380  KKIKIDLKKGPEGLGFTVVTRDSSIH---GPGPIFVKNILPKGAAIKDGRLQSGDRILEV 436
             ++K  L K   GLGF+    D+ I        + VK + P   A + G++  GD IL+V
Sbjct: 1505 FEVK--LFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKV 1562

Query: 437  NGRDVTGRTQEELVAMLRST----------------KQGETASLVIARQEGHFLPRELK- 479
            NG  + G +Q+E+++ LR T                 + +TA L   +     LP   K 
Sbjct: 1563 NGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKD 1622

Query: 480  -GEPDCCALSLETSE 493
              +P C   S  + E
Sbjct: 1623 SSQPSCVEQSTSSDE 1637



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 90/424 (21%), Positives = 159/424 (37%), Gaps = 72/424 (16%)

Query: 174  LEDREVLNGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRI-LGLF 232
            L++ +VL+  +  +++SP  + TL ++ +  +       LG  ++       GR+ LG+F
Sbjct: 1071 LKENDVLHK-RWSIVSSPEREITLVNLKKDAKYG-----LGFQIIG--GEKMGRLDLGIF 1122

Query: 233  IRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQA--------------- 277
            I  +     +  +G     + ++ +N+V L   +   A ++ + A               
Sbjct: 1123 ISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKI 1182

Query: 278  MKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNND------GVLKTKVPPPVHGKSGLKTA 331
             K PS  +H+         + S +    I  ++       G L+           GL+  
Sbjct: 1183 SKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREG 1242

Query: 332  NLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSL--SPLMGFGSNKNAKKIKIDLKKG 389
            +L+  DS    AS S  Q        LG +    S   SP     S    K+   D    
Sbjct: 1243 SLSSQDSRTESASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFTD---- 1298

Query: 390  PEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEEL 449
                     +  S    PG   V +   +G +  D    S       + +D     QE  
Sbjct: 1299 ---------SNQSKTKKPGISDVTDYSDRGDSDMDEATYS-------SSQDHQTPKQESS 1342

Query: 450  VAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSGSAGL 509
             ++  S K           + G     EL    +   +S+           L D G  G+
Sbjct: 1343 SSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTV---------LFDKG--GV 1391

Query: 510  GVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMET 569
              S++           GI++K++I  GAA  DGR+   D+++AVNG SL G ++ +A+ET
Sbjct: 1392 NTSVRHG---------GIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVET 1442

Query: 570  LRRS 573
            LR +
Sbjct: 1443 LRNT 1446



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 73/286 (25%), Positives = 113/286 (39%), Gaps = 37/286 (12%)

Query: 381  KIKIDLKKGPEG-LGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGR 439
            ++ I L K  +G LGFTV   +  I      +V +++ +  A  DGRL+ GDR+++VN  
Sbjct: 1791 ELLITLIKSEKGSLGFTVTKGNQRIG----CYVHDVI-QDPAKSDGRLKPGDRLIKVNDT 1845

Query: 440  DVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEI 499
            DVT  T  + V +LR+    +T  LVI R     LPR            +     L  +I
Sbjct: 1846 DVTNMTHTDAVNLLRAA--SKTVRLVIGRVLE--LPR------------IPMLPHLLPDI 1889

Query: 500  PLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLL 559
             L       LG SL G           ++I  I     A  +G L++ D +  VNG S  
Sbjct: 1890 TLT-CNKEELGFSLCGGHDSLYQV---VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQ 1945

Query: 560  GKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAE---------CGAFSKPCF 610
            G +  E    L  S+           L ++   +R      +          G+ S+P  
Sbjct: 1946 GMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPAL 2005

Query: 611  ENCQNAVTTSRRNDNSILHPLGTCSPQD--KQKGLLLPNDGWAESE 654
                +  T +    N I +P G CS         L LP + + + +
Sbjct: 2006 TPNDSFSTVAGEEINEISYPKGKCSTYQIKGSPNLTLPKESYIQED 2051



 Score = 34.7 bits (78), Expect = 0.51
 Identities = 29/107 (27%), Positives = 49/107 (45%), Gaps = 12/107 (11%)

Query: 490  ETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQ 549
            E   +L   +  ++ GS G  V+ KGN+       +G ++  +I   A   DGRL+  D+
Sbjct: 1787 ELEVELLITLIKSEKGSLGFTVT-KGNQR------IGCYVHDVIQDPAK-SDGRLKPGDR 1838

Query: 550  LIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPM 596
            LI VN   +   ++ +A+  LR +      + G     +L  P  PM
Sbjct: 1839 LIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR----VLELPRIPM 1881



 Score = 33.1 bits (74), Expect = 1.5
 Identities = 35/122 (28%), Positives = 53/122 (43%), Gaps = 22/122 (18%)

Query: 332  NLTGTDSPETDASAS----LQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLK 387
            N+T TD+     +AS    L   +   +PR+   P  P L P +    NK          
Sbjct: 1849 NMTHTDAVNLLRAASKTVRLVIGRVLELPRI---PMLPHLLPDITLTCNK---------- 1895

Query: 388  KGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQE 447
               E LGF++     S++    +++ +I P+  A  +G LQ  D I  VNG    G T E
Sbjct: 1896 ---EELGFSLCGGHDSLYQV--VYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLE 1950

Query: 448  EL 449
            E+
Sbjct: 1951 EV 1952


>gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens]
          Length = 728

 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 77/276 (27%), Positives = 129/276 (46%), Gaps = 48/276 (17%)

Query: 349 QNKSPRVPRLGGKPSSPSLSPLMGFGSNK--------NAKKIKIDLKKGP-EGLGFTVVT 399
           + +SP + +  G  S+ S SP  G  SN            +  ++++K P E LG TV  
Sbjct: 465 RQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAG 524

Query: 400 RDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQG 459
             S      PI+V ++ P G   +DGR+++GD +L V+G ++T  ++ E VA+L+ T   
Sbjct: 525 GASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRT--- 581

Query: 460 ETASLVIARQEGHFLPRELKGEPDCCA-LSLETSEQLT------------FEIP------ 500
            ++S+V+   E     +E + + DC +  +L+++  +              E+P      
Sbjct: 582 -SSSIVLKALE----VKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNC 636

Query: 501 ----LNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGE 556
               L  + +  LG  + G      G +   FIKSI+ G  A+ DGR+R  D L+AVNG 
Sbjct: 637 KDIVLRRNTAGSLGFCIVGGYEEYNG-NKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGR 695

Query: 557 SLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRP 592
           S  G   H  +  L +       ++G I L I+  P
Sbjct: 696 STSGMI-HACLARLLK------ELKGRITLTIVSWP 724



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 60/226 (26%), Positives = 95/226 (42%), Gaps = 24/226 (10%)

Query: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469
           I +++I   G   +DGRL  GD IL+VNG D++       V +LR   Q     L + R+
Sbjct: 301 IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQ--VLWLTVMRE 358

Query: 470 EGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSG-SAGLGVSLKGNKSRETGTDLGIF 528
           +  F  R     PD            +F + LN S     LG+ L            G+F
Sbjct: 359 Q-KFRSRNNGQAPDAYR-----PRDDSFHVILNKSSPEEQLGIKLVRKVDEP-----GVF 407

Query: 529 IKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVI 588
           I +++ GG A++ G+L  ND+++A+NG  L   S   A   ++ S          + LV+
Sbjct: 408 IFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQAS-------ERRVHLVV 460

Query: 589 LRRPERPMEDPAECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTC 634
            R+  +   D  +   ++        +     R N    LHP  TC
Sbjct: 461 SRQVRQRSPDIFQEAGWNS---NGSWSPGPGERSNTPKPLHPTITC 503


>gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens]
          Length = 632

 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 77/276 (27%), Positives = 129/276 (46%), Gaps = 48/276 (17%)

Query: 349 QNKSPRVPRLGGKPSSPSLSPLMGFGSNK--------NAKKIKIDLKKGP-EGLGFTVVT 399
           + +SP + +  G  S+ S SP  G  SN            +  ++++K P E LG TV  
Sbjct: 369 RQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAG 428

Query: 400 RDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQG 459
             S      PI+V ++ P G   +DGR+++GD +L V+G ++T  ++ E VA+L+ T   
Sbjct: 429 GASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRT--- 485

Query: 460 ETASLVIARQEGHFLPRELKGEPDCCA-LSLETSEQLT------------FEIP------ 500
            ++S+V+   E     +E + + DC +  +L+++  +              E+P      
Sbjct: 486 -SSSIVLKALE----VKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNC 540

Query: 501 ----LNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGE 556
               L  + +  LG  + G      G +   FIKSI+ G  A+ DGR+R  D L+AVNG 
Sbjct: 541 KDIVLRRNTAGSLGFCIVGGYEEYNG-NKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGR 599

Query: 557 SLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRP 592
           S  G   H  +  L +       ++G I L I+  P
Sbjct: 600 STSGMI-HACLARLLK------ELKGRITLTIVSWP 628



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 60/226 (26%), Positives = 95/226 (42%), Gaps = 24/226 (10%)

Query: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469
           I +++I   G   +DGRL  GD IL+VNG D++       V +LR   Q     L + R+
Sbjct: 205 IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQ--VLWLTVMRE 262

Query: 470 EGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSG-SAGLGVSLKGNKSRETGTDLGIF 528
           +  F  R     PD            +F + LN S     LG+ L            G+F
Sbjct: 263 Q-KFRSRNNGQAPDAYR-----PRDDSFHVILNKSSPEEQLGIKLVRKVDEP-----GVF 311

Query: 529 IKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVI 588
           I +++ GG A++ G+L  ND+++A+NG  L   S   A   ++ S          + LV+
Sbjct: 312 IFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQAS-------ERRVHLVV 364

Query: 589 LRRPERPMEDPAECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTC 634
            R+  +   D  +   ++        +     R N    LHP  TC
Sbjct: 365 SRQVRQRSPDIFQEAGWNS---NGSWSPGPGERSNTPKPLHPTITC 407


>gi|87196343 PDZ domain containing 2 [Homo sapiens]
          Length = 2839

 Score = 74.7 bits (182), Expect = 4e-13
 Identities = 56/198 (28%), Positives = 96/198 (48%), Gaps = 16/198 (8%)

Query: 387  KKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQ 446
            +K   GLGF+V     +   P  I V  +  +GAA ++G +  GD +L VNG  + G   
Sbjct: 2627 RKEGSGLGFSVA--GGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAH 2684

Query: 447  EELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFE------IP 500
              ++ +L   +  + A +VI +      P   +  P      L + + +  E      + 
Sbjct: 2685 GNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRSVA 2744

Query: 501  LNDS-------GSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAV 553
            ++D+        SAGLG+SL G KS  TG D  + IK +  GGAA + G +   D+++A+
Sbjct: 2745 VHDALCVEVLKTSAGLGLSLDGGKSSVTG-DGPLVIKRVYKGGAAEQAGIIEAGDEILAI 2803

Query: 554  NGESLLGKSNHEAMETLR 571
            NG+ L+G  + +A   ++
Sbjct: 2804 NGKPLVGLMHFDAWNIMK 2821



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 115/489 (23%), Positives = 190/489 (38%), Gaps = 93/489 (19%)

Query: 387  KKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQ 446
            K+  +GLGF++      I G   IFVK I P G+A +DGRL+ GD IL+VNG  + G T 
Sbjct: 591  KEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTF 650

Query: 447  EELVAMLRSTKQGETASLVIARQEGHFL-----PREL------------------KGEPD 483
            +E +   +  + G     V  +     L     P  +                    E  
Sbjct: 651  QEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGS 710

Query: 484  CCALSLET---SEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFK 540
              +L  +T    +++  E+ LN     GLG+         +    GI+I S+  G  A  
Sbjct: 711  SSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPP--GIYIHSLAPGSVAKM 768

Query: 541  DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPA 600
            +  L   DQ++ VN  ++     H A+  +   +S      G ++LVI R P   + +  
Sbjct: 769  ESNLSRGDQILEVNSVNV----RHAALSKVHAILSK--CPPGPVRLVIGRHPNPKVSEQE 822

Query: 601  ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGT--CSPQDKQKGLLLPNDGWAESEVPPS 658
                 ++  ++  + A ++           LGT   SP   +K  L+     ++      
Sbjct: 823  MDEVIARSTYQESKEANSSP---------GLGTPLKSPSLAKKDSLISESELSQYFAHDV 873

Query: 659  PTPHS-ALGLGLEDYSH-SSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPD 716
            P P S  +  G ED  H  SG  ++                   E  +L  S S    P 
Sbjct: 874  PGPLSDFMVAGSEDEDHPGSGCSTS-------------------EEGSLPPSTSTHKEPG 914

Query: 717  ESKVHSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPF--HRPRPHMVRG 774
            + + +SL              TLG  ++S L   Q  VA  R+  LP      R  ++R 
Sbjct: 915  KPRANSLV-------------TLGSHRASGLFHKQVTVA--RQASLPGSPQALRNPLLRQ 959

Query: 775  R--GCNESFRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQ----GNSELEDME 828
            R  GC ++  A+ ++ +D     E D +S   +  G      E  P+     +S+  D+ 
Sbjct: 960  RKVGCYDANDASDEEEFDR----EGDCISLPGALPGPIRPLSEDDPRRVSISSSKGMDVH 1015

Query: 829  NKARKVKKT 837
            N+  + +KT
Sbjct: 1016 NQEERPRKT 1024



 Score = 57.4 bits (137), Expect = 7e-08
 Identities = 47/133 (35%), Positives = 65/133 (48%), Gaps = 9/133 (6%)

Query: 339 PETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKI-KIDLKKGPEGLGFTV 397
           P+TDA  +   +K  R    GGK    S   L    + +   +I K++L K  +GLG  V
Sbjct: 295 PKTDAPLTTSNDK--RRFSKGGKTDFQSSDCL----AREEVGRIWKMELLKESDGLGIQV 348

Query: 398 VTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTK 457
                S   P  I V  +   GAA +DGRL  GD +L +NG  + G + EE VA+LRS  
Sbjct: 349 SGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSAT 408

Query: 458 QGETASLVIARQE 470
                 LV+A +E
Sbjct: 409 --GMVQLVVASKE 419



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 37/120 (30%), Positives = 61/120 (50%), Gaps = 9/120 (7%)

Query: 506 SAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHE 565
           S GLG+ + G +  +      I +  +  GGAA +DGRL + D+L+ +NG  L+G S+ E
Sbjct: 341 SDGLGIQVSGGRGSKRSPH-AIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEE 399

Query: 566 AMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKPCFENCQNAVTTSRRNDN 625
           A+  LR       +  GM+QLV+  + E   ED     + S P   +    V++   N++
Sbjct: 400 AVAILR-------SATGMVQLVVASK-ENSAEDLLRLTSKSLPDLTSSVEDVSSWTDNED 451



 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 24/82 (29%), Positives = 46/82 (56%)

Query: 384  IDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTG 443
            +++ K   GLG ++    SS+ G GP+ +K +   GAA + G +++GD IL +NG+ + G
Sbjct: 2751 VEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVG 2810

Query: 444  RTQEELVAMLRSTKQGETASLV 465
                +   +++S  +G    L+
Sbjct: 2811 LMHFDAWNIMKSVPEGPVQLLI 2832



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 71/311 (22%), Positives = 120/311 (38%), Gaps = 59/311 (18%)

Query: 209 EGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFA 268
           +G  LG  +      + G+ +G+F++ I  N  +  +G   E + I+ +N + +   TF 
Sbjct: 593 KGKGLGFSIAGGRDCIRGQ-MGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQ 651

Query: 269 QAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGL 328
           +A   F+Q      VL                             ++TK+  P       
Sbjct: 652 EAIHTFKQIRSGLFVL----------------------------TVRTKLVSPSLTPCST 683

Query: 329 KTANLTGTDSPE--TDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDL 386
            T +++ + SP   T   AS   +       LG K   P           K+   +++ L
Sbjct: 684 PT-HMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPGP-----------KDRIVMEVTL 731

Query: 387 KKGPE---GLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTG 443
            K P    G+G   +  ++S   P  I++ ++ P   A  +  L  GD+ILEVN  +V  
Sbjct: 732 NKEPRVGLGIGACCLALENS---PPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRH 788

Query: 444 RTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLND 503
               ++ A+L     G    LVI R   H  P+  + E D      E   + T++     
Sbjct: 789 AALSKVHAILSKCPPG-PVRLVIGR---HPNPKVSEQEMD------EVIARSTYQESKEA 838

Query: 504 SGSAGLGVSLK 514
           + S GLG  LK
Sbjct: 839 NSSPGLGTPLK 849



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 33/117 (28%), Positives = 55/117 (47%), Gaps = 10/117 (8%)

Query: 490  ETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDL---GIFIKSIIHGGAAFKDGRLRM 546
            E  E + F I LN    +GLG S+ G      GTD+    I +  +   GAA ++G +  
Sbjct: 2615 ENEEDVCF-IVLNRKEGSGLGFSVAG------GTDVEPKSITVHRVFSQGAASQEGTMNR 2667

Query: 547  NDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECG 603
             D L++VNG SL G ++   ++ L ++   +  +  + + +   RP    E P   G
Sbjct: 2668 GDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANG 2724



 Score = 33.1 bits (74), Expect = 1.5
 Identities = 23/87 (26%), Positives = 44/87 (50%), Gaps = 10/87 (11%)

Query: 510 GVSLKGNKSRETGT----DLG-IFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNH 564
           G   +G K R+T      D+G I++  +     A K G++R+ D+++++NG+ ++G    
Sbjct: 97  GEKRRGGKKRKTHQGPVLDVGCIWVTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVS 156

Query: 565 EAMETLRRSMSMEGNIRGMIQLVILRR 591
            A     +  +      G I L++LRR
Sbjct: 157 GASYLAEQCWN-----GGFIYLIMLRR 178


>gi|218505835 membrane-associated guanylate kinase-related  3 isoform
            1 [Homo sapiens]
          Length = 1481

 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 146/697 (20%), Positives = 256/697 (36%), Gaps = 159/697 (22%)

Query: 335  GTDSPETDASASL--QQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEG 392
            G   PE D+S +    QN SPR+ R    P+ P+          +    + +  K+  EG
Sbjct: 813  GEKQPEDDSSQAFISTQNGSPRLNR-AEVPARPA---------PQEPYDVVLQRKEN-EG 861

Query: 393  LGFTVVT-RDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVA 451
             GF ++T ++    G  P  +  ++    A + G+L+ GD I  VNG+ +   + + +V 
Sbjct: 862  FGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQ 921

Query: 452  MLRSTKQGETASLVIARQEGHFLPRE------------------------------LKGE 481
            +++    G T +L +  +E H  P                                L+GE
Sbjct: 922  LIKDA--GVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGE 979

Query: 482  ---------------------PDCCALSLETSEQLT----FEIPLNDSGSAGLGVSLKGN 516
                                 PD   +S+  S        + + L + G  G G SL+G 
Sbjct: 980  IGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVEL-ERGPRGFGFSLRGG 1038

Query: 517  KSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSM 576
            K      ++G+FI  +   G A KDGR+ + DQ++ +NGE   G ++  A+E ++   + 
Sbjct: 1039 KEY----NMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNK 1094

Query: 577  ----------------EGNIRGMIQLVILRRPERPMEDPAECGAFSK----PCFENCQNA 616
                            + +I       ++   + P+   +   +  +    P  E     
Sbjct: 1095 VLLLLRPGTGLIPDHGDWDINNPSSSNVIYDEQSPLPPSSHFASIFEESHVPVIEESLRV 1154

Query: 617  VTTSRRNDNSILHP-----LGTCSPQDKQKGLLLPNDGWAESEVPPSPTPHSALGLGLED 671
                +  +   + P     L    P+ K + LL  N        PPS   HS       +
Sbjct: 1155 QICEKAEELKDIVPEKKSTLNENQPEIKHQSLLQKN---VSKRDPPSSHGHS-------N 1204

Query: 672  YSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKVHSLAGQKSESP 731
              +   V++ V         RSV+P ++P S +  + + +D +P   K +     + +S 
Sbjct: 1205 KKNLLKVENGV-----TRRGRSVSP-KKPASQH--SEEHLDKIPSPLKNNPKRRPRDQSL 1256

Query: 732  SKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNESFRAAIDKSYDG 791
            S   G     + S+   S Q    + RK+            RGR  +   +  I+ S   
Sbjct: 1257 SPSKGENKSCQVSTRAGSGQD---QCRKS------------RGRSASPKKQQKIEGS-KA 1300

Query: 792  PEEIEADGLSDKSSH-SGQGALNCESAPQGNSELEDMENKARKVKKTKEKEKKKEKGKLK 850
            P   EA  L  KS   +G    N E  P G  + + +   A++ +  K + +  EK   +
Sbjct: 1301 PSNAEAKLLEGKSRRIAGYTGSNAEQIPDGKEKSDVIRKDAKQNQLEKSRTRSPEKKIKR 1360

Query: 851  VKEK------------KRKEENE--------DPERKIKKKGFGAMLRFGKKKEDKGGKAE 890
            + EK            K   ENE        +      K G    L   + K++   K  
Sbjct: 1361 MVEKSLPSKMTNKTTSKEVSENEKGKKVTTGETSSSNDKIGENVQLSEKRLKQEPEEKVV 1420

Query: 891  QKGTLKHGGLREEELEKMKEERESGRPTGGSTDRIQK 927
               T  H G   +ELE   + +E+GR    S+  ++K
Sbjct: 1421 SNKTEDHKG---KELEAADKNKETGRFKPESSSPVKK 1454



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 67/273 (24%), Positives = 125/273 (45%), Gaps = 34/273 (12%)

Query: 326 SGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPS-----SPSLSPLMGFGSNK--- 377
           S  KTA +  TD  E   + SL+    P    +   PS     SP L P   +  +K   
Sbjct: 659 SPTKTAKMK-TDKKEN--AGSLEAINEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLY 715

Query: 378 -----NAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGP-IFVKNILPKGAAIKDGRLQSGD 431
                N K + + L+K   G GF V+  D    GP   I++  I+P GAA KDGRL++ D
Sbjct: 716 EDKPPNTKDLDVFLRKQESGFGFRVLGGD----GPDQSIYIGAIIPLGAAEKDGRLRAAD 771

Query: 432 RILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ--EGHFLPRE---------LKG 480
            ++ ++G  V G++ ++++ ++ +  +     L + R+   G   P +           G
Sbjct: 772 ELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNG 831

Query: 481 EP--DCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAA 538
            P  +   +    + Q  +++ L    + G G  +  +K++     +   I  +I G  A
Sbjct: 832 SPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPA 891

Query: 539 FKDGRLRMNDQLIAVNGESLLGKSNHEAMETLR 571
            + G+L++ D + AVNG+S++  S+   ++ ++
Sbjct: 892 DRCGKLKVGDHISAVNGQSIVELSHDNIVQLIK 924



 Score = 53.9 bits (128), Expect = 8e-07
 Identities = 31/94 (32%), Positives = 50/94 (53%), Gaps = 5/94 (5%)

Query: 382 IKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDV 441
           ++  LKK   G GFT++  D        + VKN+L  G A +DG++  GD I+++NG  V
Sbjct: 409 VRASLKKSTMGFGFTIIGGDRPDEF---LQVKNVLKDGPAAQDGKIAPGDVIVDINGNCV 465

Query: 442 TGRTQEELVAMLRSTKQGETASLVIARQEGHFLP 475
            G T  ++V M +     +  +L + R  G+ LP
Sbjct: 466 LGHTHADVVQMFQLVPVNQYVNLTLCR--GYPLP 497



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 75/322 (23%), Positives = 123/322 (38%), Gaps = 50/322 (15%)

Query: 320 PPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRV---PRLGGKPSSPSLSPLMGFGSN 376
           P ++G+S  K          +  A    Q  KS        L G   +      M    +
Sbjct: 512 PVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGS 571

Query: 377 KNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEV 436
              + + I L KGP+G GF +         P    VK IL          LQ GD I E+
Sbjct: 572 SQPELVTIPLIKGPKGFGFAIAD------SPTGQKVKMILDSQWC---QGLQKGDIIKEI 622

Query: 437 NGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPD-------CCALSL 489
             ++V   T  ++V +L+    G    L+I R       +  K + D         A++ 
Sbjct: 623 YHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINE 682

Query: 490 ETSEQLTFEIPLNDSGSAGLGVSLKGNKSRET---------------------------- 521
              + + F   +  SGS  L  S    KS+                              
Sbjct: 683 PIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLG 742

Query: 522 --GTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGN 579
             G D  I+I +II  GAA KDGRLR  D+L+ ++G  + GKS+ + ++ L  + +  G+
Sbjct: 743 GDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLD-LMTTAARNGH 801

Query: 580 IRGMIQLVILRRPERPMEDPAE 601
           +   ++  I    ++P +D ++
Sbjct: 802 VLLTVRRKIFYGEKQPEDDSSQ 823



 Score = 31.2 bits (69), Expect = 5.7
 Identities = 10/40 (25%), Positives = 26/40 (65%)

Query: 529 IKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAME 568
           +K+++  G A +DG++   D ++ +NG  +LG ++ + ++
Sbjct: 436 VKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQ 475


>gi|27262655 interleukin 16 isoform 1 precursor [Homo sapiens]
          Length = 631

 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 51/198 (25%), Positives = 94/198 (47%), Gaps = 15/198 (7%)

Query: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469
           I V  + P G A ++G +Q G+ +L +NG+ + G T  + +A+LR  ++   A +V  + 
Sbjct: 438 ITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKL 497

Query: 470 EGHFLPRELKGEPDCCA-------LSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETG 522
               +P +L    D  A       +S+E++ + T      +  SAGLG SL+G K    G
Sbjct: 498 TPEAMP-DLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHG 556

Query: 523 TDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRG 582
            D  + I  I  G A+ +   ++  D+++ + G ++ G +  EA   ++          G
Sbjct: 557 -DKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPD------G 609

Query: 583 MIQLVILRRPERPMEDPA 600
            + +VI R+  +  E  A
Sbjct: 610 PVTIVIRRKSLQSKETTA 627



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 36/144 (25%), Positives = 63/144 (43%), Gaps = 17/144 (11%)

Query: 342 DASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG----------------SNKNAKKIKID 385
           DA A L+Q + PR   +  +  +P   P +                   S   A    + 
Sbjct: 476 DALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVT 535

Query: 386 LKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRT 445
           L+K   GLGF++     S+HG  P+ +  I    A+ +   +Q GD IL++ G  + G T
Sbjct: 536 LEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLT 595

Query: 446 QEELVAMLRSTKQGETASLVIARQ 469
           + E   ++++   G   ++VI R+
Sbjct: 596 RFEAWNIIKALPDG-PVTIVIRRK 618


>gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo
            sapiens]
          Length = 1287

 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 93/379 (24%), Positives = 152/379 (40%), Gaps = 64/379 (16%)

Query: 230  GLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLP 289
            G+FI  I     +++         I+ +N++ L   TF  A    R    SP        
Sbjct: 780  GIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMA---VRMIQNSP-------- 828

Query: 290  PQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQ 349
                +  E  +  S  + GNN    K          SG+ + ++       +  S +  Q
Sbjct: 829  ----DNIELIISQSKGVGGNNPDEEKNST-----ANSGVSSTDILSFGYQGSLLSHTQDQ 879

Query: 350  NKSPRVPRLGGKPS-------SPSLSPLMGFGSNKNAKKIKI--------DLKKGPEGLG 394
            +++     + G  S         S  PL G GS+      +I        +L K    LG
Sbjct: 880  DRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTLG 939

Query: 395  FTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLR 454
            F+V    ++    G I+VK+I+P G A K+G++  GDR+L+V+G  + G T ++ V  L 
Sbjct: 940  FSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCL- 998

Query: 455  STKQGETASLVIAR-------------------QEGHFLPRELKGEPDCCALSLETSEQL 495
             T  G+ A LV+ R                   +    L   L G P  C   +  ++  
Sbjct: 999  -TGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSC---VSVTDGP 1054

Query: 496  TFEIPLNDSGSAGLG---VSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIA 552
             FE+ L  + + GLG   V ++        +DL + IK +  G  A ++G +   D ++A
Sbjct: 1055 KFEVKLKKNAN-GLGFSFVQMEKESCSHLKSDL-VRIKRLFPGQPAEENGAIAAGDIILA 1112

Query: 553  VNGESLLGKSNHEAMETLR 571
            VNG S  G    E +  LR
Sbjct: 1113 VNGRSTEGLIFQEVLHLLR 1131



 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 82/334 (24%), Positives = 132/334 (39%), Gaps = 71/334 (21%)

Query: 204  VEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLV 263
            VE+  E G LG  V    ++ S    G++++ I     + +EG   + + +++++ V L 
Sbjct: 929  VELVKEDGTLGFSVTGGINT-SVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILC 987

Query: 264  DKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVH 323
              T  QA     Q +  P  +  +                         VL+ +VP    
Sbjct: 988  GLTHKQAV----QCLTGPGQVARL-------------------------VLERRVPRSTQ 1018

Query: 324  GKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIK 383
                           P  + S   ++     V  L G+PSS          S  +  K +
Sbjct: 1019 -------------QCPSANDSMGDERTAVSLVTALPGRPSSCV--------SVTDGPKFE 1057

Query: 384  IDLKKGPEGLGFTVVT--RDSSIHGPGPIF-VKNILPKGAAIKDGRLQSGDRILEVNGRD 440
            + LKK   GLGF+ V   ++S  H    +  +K + P   A ++G + +GD IL VNGR 
Sbjct: 1058 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 1117

Query: 441  VTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLE---------- 490
              G   +E++ +LR   Q  T  L++ R     LP EL+ E     LS +          
Sbjct: 1118 TEGLIFQEVLHLLRGAPQEVT--LLLCRPPPGALP-ELEQEWQTPELSADKEFTRATCTD 1174

Query: 491  --TSEQLTFEIPLNDSGS--AGLGVSLKGNKSRE 520
              TS  L  E    DS S  AG G+ L+   S++
Sbjct: 1175 SCTSPILDQEDSWRDSASPDAGEGLGLRPESSQK 1208



 Score = 40.8 bits (94), Expect = 0.007
 Identities = 30/112 (26%), Positives = 54/112 (48%), Gaps = 13/112 (11%)

Query: 371 MGFGSNKNAKK----------IKIDLKKGPE-GLGFTVVTRDSSIHGPGPIFVKNILPKG 419
           M  GS  N +K          +++ LK+ P  G GF +   + S      IF+ +I+P G
Sbjct: 731 MHAGSKNNRRKSFIAEPGREIVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGG 790

Query: 420 AAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEG 471
            A K   ++ G +IL +N   + G T    V M++++   +   L+I++ +G
Sbjct: 791 PAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSP--DNIELIISQSKG 840



 Score = 37.7 bits (86), Expect = 0.060
 Identities = 52/188 (27%), Positives = 81/188 (43%), Gaps = 18/188 (9%)

Query: 524 DLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGM 583
           D GIFI SII GG A K   ++   Q++A+N  SL G + + A+  ++ S      I   
Sbjct: 778 DPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELIISQ 837

Query: 584 IQLVILRRPERPMEDPAECGAFSKPC----FENCQNAVTTSRRNDNSILHPLGTCS--PQ 637
            + V    P+      A  G  S       ++    + T  +  +   L   G  S  P+
Sbjct: 838 SKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSHTQDQDRNTEELDMAGVQSLVPR 897

Query: 638 DKQKGLLLPNDGWAESEVPPSPTPHSA-----LGLGLED----YSHSSGVDSAVYFPDQH 688
            + +   LP  G A S  PPSP   SA     + L  ED    +S + G++++V  P   
Sbjct: 898 LRHQLSFLPLKG-AGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSV--PYGG 954

Query: 689 INFRSVTP 696
           I  +S+ P
Sbjct: 955 IYVKSIVP 962


>gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo
            sapiens]
          Length = 1309

 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 93/379 (24%), Positives = 152/379 (40%), Gaps = 64/379 (16%)

Query: 230  GLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLP 289
            G+FI  I     +++         I+ +N++ L   TF  A    R    SP        
Sbjct: 802  GIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMA---VRMIQNSP-------- 850

Query: 290  PQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQ 349
                +  E  +  S  + GNN    K          SG+ + ++       +  S +  Q
Sbjct: 851  ----DNIELIISQSKGVGGNNPDEEKNST-----ANSGVSSTDILSFGYQGSLLSHTQDQ 901

Query: 350  NKSPRVPRLGGKPS-------SPSLSPLMGFGSNKNAKKIKI--------DLKKGPEGLG 394
            +++     + G  S         S  PL G GS+      +I        +L K    LG
Sbjct: 902  DRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTLG 961

Query: 395  FTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLR 454
            F+V    ++    G I+VK+I+P G A K+G++  GDR+L+V+G  + G T ++ V  L 
Sbjct: 962  FSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCL- 1020

Query: 455  STKQGETASLVIAR-------------------QEGHFLPRELKGEPDCCALSLETSEQL 495
             T  G+ A LV+ R                   +    L   L G P  C   +  ++  
Sbjct: 1021 -TGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSC---VSVTDGP 1076

Query: 496  TFEIPLNDSGSAGLG---VSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIA 552
             FE+ L  + + GLG   V ++        +DL + IK +  G  A ++G +   D ++A
Sbjct: 1077 KFEVKLKKNAN-GLGFSFVQMEKESCSHLKSDL-VRIKRLFPGQPAEENGAIAAGDIILA 1134

Query: 553  VNGESLLGKSNHEAMETLR 571
            VNG S  G    E +  LR
Sbjct: 1135 VNGRSTEGLIFQEVLHLLR 1153



 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 82/334 (24%), Positives = 132/334 (39%), Gaps = 71/334 (21%)

Query: 204  VEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLV 263
            VE+  E G LG  V    ++ S    G++++ I     + +EG   + + +++++ V L 
Sbjct: 951  VELVKEDGTLGFSVTGGINT-SVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILC 1009

Query: 264  DKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVH 323
              T  QA     Q +  P  +  +                         VL+ +VP    
Sbjct: 1010 GLTHKQAV----QCLTGPGQVARL-------------------------VLERRVPRSTQ 1040

Query: 324  GKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIK 383
                           P  + S   ++     V  L G+PSS          S  +  K +
Sbjct: 1041 -------------QCPSANDSMGDERTAVSLVTALPGRPSSCV--------SVTDGPKFE 1079

Query: 384  IDLKKGPEGLGFTVVT--RDSSIHGPGPIF-VKNILPKGAAIKDGRLQSGDRILEVNGRD 440
            + LKK   GLGF+ V   ++S  H    +  +K + P   A ++G + +GD IL VNGR 
Sbjct: 1080 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 1139

Query: 441  VTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLE---------- 490
              G   +E++ +LR   Q  T  L++ R     LP EL+ E     LS +          
Sbjct: 1140 TEGLIFQEVLHLLRGAPQEVT--LLLCRPPPGALP-ELEQEWQTPELSADKEFTRATCTD 1196

Query: 491  --TSEQLTFEIPLNDSGS--AGLGVSLKGNKSRE 520
              TS  L  E    DS S  AG G+ L+   S++
Sbjct: 1197 SCTSPILDQEDSWRDSASPDAGEGLGLRPESSQK 1230



 Score = 40.8 bits (94), Expect = 0.007
 Identities = 30/112 (26%), Positives = 54/112 (48%), Gaps = 13/112 (11%)

Query: 371 MGFGSNKNAKK----------IKIDLKKGPE-GLGFTVVTRDSSIHGPGPIFVKNILPKG 419
           M  GS  N +K          +++ LK+ P  G GF +   + S      IF+ +I+P G
Sbjct: 753 MHAGSKNNRRKSFIAEPGREIVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGG 812

Query: 420 AAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEG 471
            A K   ++ G +IL +N   + G T    V M++++   +   L+I++ +G
Sbjct: 813 PAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSP--DNIELIISQSKG 862



 Score = 37.7 bits (86), Expect = 0.060
 Identities = 52/188 (27%), Positives = 81/188 (43%), Gaps = 18/188 (9%)

Query: 524 DLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGM 583
           D GIFI SII GG A K   ++   Q++A+N  SL G + + A+  ++ S      I   
Sbjct: 800 DPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELIISQ 859

Query: 584 IQLVILRRPERPMEDPAECGAFSKPC----FENCQNAVTTSRRNDNSILHPLGTCS--PQ 637
            + V    P+      A  G  S       ++    + T  +  +   L   G  S  P+
Sbjct: 860 SKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSHTQDQDRNTEELDMAGVQSLVPR 919

Query: 638 DKQKGLLLPNDGWAESEVPPSPTPHSA-----LGLGLED----YSHSSGVDSAVYFPDQH 688
            + +   LP  G A S  PPSP   SA     + L  ED    +S + G++++V  P   
Sbjct: 920 LRHQLSFLPLKG-AGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSV--PYGG 976

Query: 689 INFRSVTP 696
           I  +S+ P
Sbjct: 977 IYVKSIVP 984


>gi|155969695 membrane-associated guanylate kinase-related  3
           isoform 2 [Homo sapiens]
          Length = 1125

 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 67/273 (24%), Positives = 125/273 (45%), Gaps = 34/273 (12%)

Query: 326 SGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPS-----SPSLSPLMGFGSNK--- 377
           S  KTA +  TD  E   + SL+    P    +   PS     SP L P   +  +K   
Sbjct: 659 SPTKTAKMK-TDKKEN--AGSLEAINEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLY 715

Query: 378 -----NAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGP-IFVKNILPKGAAIKDGRLQSGD 431
                N K + + L+K   G GF V+  D    GP   I++  I+P GAA KDGRL++ D
Sbjct: 716 EDKPPNTKDLDVFLRKQESGFGFRVLGGD----GPDQSIYIGAIIPLGAAEKDGRLRAAD 771

Query: 432 RILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ--EGHFLPRE---------LKG 480
            ++ ++G  V G++ ++++ ++ +  +     L + R+   G   P +           G
Sbjct: 772 ELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNG 831

Query: 481 EP--DCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAA 538
            P  +   +    + Q  +++ L    + G G  +  +K++     +   I  +I G  A
Sbjct: 832 SPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPA 891

Query: 539 FKDGRLRMNDQLIAVNGESLLGKSNHEAMETLR 571
            + G+L++ D + AVNG+S++  S+   ++ ++
Sbjct: 892 DRCGKLKVGDHISAVNGQSIVELSHDNIVQLIK 924



 Score = 64.7 bits (156), Expect = 5e-10
 Identities = 69/295 (23%), Positives = 120/295 (40%), Gaps = 76/295 (25%)

Query: 335  GTDSPETDASASL--QQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEG 392
            G   PE D+S +    QN SPR+ R    P+ P+          +    + +  K+  EG
Sbjct: 813  GEKQPEDDSSQAFISTQNGSPRLNR-AEVPARPA---------PQEPYDVVLQRKEN-EG 861

Query: 393  LGFTVVT-RDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVA 451
             GF ++T ++    G  P  +  ++    A + G+L+ GD I  VNG+ +   + + +V 
Sbjct: 862  FGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQ 921

Query: 452  MLRSTKQGETASLVIARQEGHFLPRE------------------------------LKGE 481
            +++    G T +L +  +E H  P                                L+GE
Sbjct: 922  LIKDA--GVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGE 979

Query: 482  ---------------------PDCCALSLETSEQLT----FEIPLNDSGSAGLGVSLKGN 516
                                 PD   +S+  S        + + L + G  G G SL+G 
Sbjct: 980  IGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVEL-ERGPRGFGFSLRGG 1038

Query: 517  KSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLR 571
            K      ++G+FI  +   G A KDGR+ + DQ++ +NGE   G ++  A+E ++
Sbjct: 1039 KEY----NMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQ 1089



 Score = 53.9 bits (128), Expect = 8e-07
 Identities = 31/94 (32%), Positives = 50/94 (53%), Gaps = 5/94 (5%)

Query: 382 IKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDV 441
           ++  LKK   G GFT++  D        + VKN+L  G A +DG++  GD I+++NG  V
Sbjct: 409 VRASLKKSTMGFGFTIIGGDRPDEF---LQVKNVLKDGPAAQDGKIAPGDVIVDINGNCV 465

Query: 442 TGRTQEELVAMLRSTKQGETASLVIARQEGHFLP 475
            G T  ++V M +     +  +L + R  G+ LP
Sbjct: 466 LGHTHADVVQMFQLVPVNQYVNLTLCR--GYPLP 497



 Score = 53.9 bits (128), Expect = 8e-07
 Identities = 27/86 (31%), Positives = 49/86 (56%), Gaps = 3/86 (3%)

Query: 370  LMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQS 429
            ++G   N+N     ++L++GP G GF++  R    +  G +F+  +   G AIKDGR+  
Sbjct: 1008 VVGSRHNQNLGCYPVELERGPRGFGFSL--RGGKEYNMG-LFILRLAEDGPAIKDGRIHV 1064

Query: 430  GDRILEVNGRDVTGRTQEELVAMLRS 455
            GD+I+E+NG    G T    + ++++
Sbjct: 1065 GDQIVEINGEPTQGITHTRAIELIQA 1090



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 75/322 (23%), Positives = 123/322 (38%), Gaps = 50/322 (15%)

Query: 320 PPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRV---PRLGGKPSSPSLSPLMGFGSN 376
           P ++G+S  K          +  A    Q  KS        L G   +      M    +
Sbjct: 512 PVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGS 571

Query: 377 KNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEV 436
              + + I L KGP+G GF +         P    VK IL          LQ GD I E+
Sbjct: 572 SQPELVTIPLIKGPKGFGFAIAD------SPTGQKVKMILDSQWC---QGLQKGDIIKEI 622

Query: 437 NGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPD-------CCALSL 489
             ++V   T  ++V +L+    G    L+I R       +  K + D         A++ 
Sbjct: 623 YHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINE 682

Query: 490 ETSEQLTFEIPLNDSGSAGLGVSLKGNKSRET---------------------------- 521
              + + F   +  SGS  L  S    KS+                              
Sbjct: 683 PIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLG 742

Query: 522 --GTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGN 579
             G D  I+I +II  GAA KDGRLR  D+L+ ++G  + GKS+ + ++ L  + +  G+
Sbjct: 743 GDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLD-LMTTAARNGH 801

Query: 580 IRGMIQLVILRRPERPMEDPAE 601
           +   ++  I    ++P +D ++
Sbjct: 802 VLLTVRRKIFYGEKQPEDDSSQ 823



 Score = 31.2 bits (69), Expect = 5.7
 Identities = 10/40 (25%), Positives = 26/40 (65%)

Query: 529 IKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAME 568
           +K+++  G A +DG++   D ++ +NG  +LG ++ + ++
Sbjct: 436 VKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQ 475


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.133    0.388 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 50,983,177
Number of Sequences: 37866
Number of extensions: 2982388
Number of successful extensions: 23128
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 392
Number of HSP's successfully gapped in prelim test: 814
Number of HSP's that attempted gapping in prelim test: 13374
Number of HSP's gapped (non-prelim): 6242
length of query: 1104
length of database: 18,247,518
effective HSP length: 113
effective length of query: 991
effective length of database: 13,968,660
effective search space: 13842942060
effective search space used: 13842942060
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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