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Search of human proteins with 118600961
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|118600961 akt substrate AS250 [Homo sapiens]
(1873 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|118600961 akt substrate AS250 [Homo sapiens] 3761 0.0
gi|51230412 GTPase activating Rap/RanGAP domain-like 1 isoform 2... 1148 0.0
gi|51226124 GTPase activating Rap/RanGAP domain-like 1 isoform 1... 1148 0.0
gi|116256350 tuberous sclerosis 2 isoform 4 [Homo sapiens] 101 8e-21
gi|116256352 tuberous sclerosis 2 isoform 1 [Homo sapiens] 101 8e-21
gi|167412124 tuberous sclerosis 2 isoform 5 [Homo sapiens] 101 8e-21
gi|224809582 RAP1 GTPase activating protein isoform c [Homo sapi... 82 6e-15
gi|224809578 RAP1 GTPase activating protein isoform a [Homo sapi... 82 6e-15
gi|224809573 RAP1 GTPase activating protein isoform b [Homo sapi... 82 6e-15
gi|207448705 GTPase activating Rap/RanGAP domain-like 3 [Homo sa... 77 1e-13
gi|156086740 GTPase activating Rap/RanGAP domain-like 4 isoform ... 77 2e-13
gi|156086724 GTPase activating Rap/RanGAP domain-like 4 isoform ... 77 2e-13
gi|71143119 signal-induced proliferation-associated 1 like 3 [Ho... 74 1e-12
gi|7662126 signal-induced proliferation-associated 1 like 1 [Hom... 71 9e-12
gi|112421013 signal-induced proliferation-associated 1 like 2 [H... 70 1e-11
gi|206725526 signal-induced proliferation-associated protein 1 [... 64 1e-09
gi|206725523 signal-induced proliferation-associated protein 1 [... 64 1e-09
gi|34787409 hypothetical protein LOC57148 [Homo sapiens] 62 4e-09
gi|108773787 retinoblastoma 1 [Homo sapiens] 37 0.18
gi|122937211 KIAA0368 protein [Homo sapiens] 35 0.69
gi|28460688 taxilin [Homo sapiens] 34 1.5
gi|7661950 SH2 domain binding protein 1 [Homo sapiens] 34 1.5
gi|171184451 centrosome-associated protein 350 [Homo sapiens] 34 1.5
gi|155969714 nuclear protein, ataxia-telangiectasia locus [Homo... 33 2.6
gi|40538728 pleckstrin homology domain containing, family M (wit... 33 3.4
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 33 3.4
gi|51873049 hypothetical protein LOC8603 [Homo sapiens] 33 3.4
gi|33356174 pinin, desmosome associated protein [Homo sapiens] 33 3.4
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 33 3.4
gi|28557802 sterile alpha motif domain containing 14 [Homo sapiens] 33 3.4
>gi|118600961 akt substrate AS250 [Homo sapiens]
Length = 1873
Score = 3761 bits (9753), Expect = 0.0
Identities = 1873/1873 (100%), Positives = 1873/1873 (100%)
Query: 1 MFSRRSHGDVKKSTQKVLDPKKDVLTRLKHLRALLDNVDANDLKQFFETNYSQIYFIFYE 60
MFSRRSHGDVKKSTQKVLDPKKDVLTRLKHLRALLDNVDANDLKQFFETNYSQIYFIFYE
Sbjct: 1 MFSRRSHGDVKKSTQKVLDPKKDVLTRLKHLRALLDNVDANDLKQFFETNYSQIYFIFYE 60
Query: 61 NFIALENSLKLKGNNKSQREELDSILFLFEKILQFLPERIFFRWHYQSIGSTLKKLLHTG 120
NFIALENSLKLKGNNKSQREELDSILFLFEKILQFLPERIFFRWHYQSIGSTLKKLLHTG
Sbjct: 61 NFIALENSLKLKGNNKSQREELDSILFLFEKILQFLPERIFFRWHYQSIGSTLKKLLHTG 120
Query: 121 NSIKIRCEGIRLFLLWLQALQTNCAEEQVLIFACLVPGFPAVMSSRGPCTLETLINPSPS 180
NSIKIRCEGIRLFLLWLQALQTNCAEEQVLIFACLVPGFPAVMSSRGPCTLETLINPSPS
Sbjct: 121 NSIKIRCEGIRLFLLWLQALQTNCAEEQVLIFACLVPGFPAVMSSRGPCTLETLINPSPS 180
Query: 181 VADVKIYPEEITPLLPAISGEKIAEDQTCFFLQILLKYMVIQAASLEWKNKENQDTGFKF 240
VADVKIYPEEITPLLPAISGEKIAEDQTCFFLQILLKYMVIQAASLEWKNKENQDTGFKF
Sbjct: 181 VADVKIYPEEITPLLPAISGEKIAEDQTCFFLQILLKYMVIQAASLEWKNKENQDTGFKF 240
Query: 241 LFTLFRKYYLPHLFPSFTKLTNIYKPVLDIPHLRPKPVYITTTRDNENIYSTKIPYMAAR 300
LFTLFRKYYLPHLFPSFTKLTNIYKPVLDIPHLRPKPVYITTTRDNENIYSTKIPYMAAR
Sbjct: 241 LFTLFRKYYLPHLFPSFTKLTNIYKPVLDIPHLRPKPVYITTTRDNENIYSTKIPYMAAR 300
Query: 301 VVFIKWIVTFFLEKKYLTATQNTKNGVDVLPKIIQTVGGGAVQERAPELDGGGPTEQDKS 360
VVFIKWIVTFFLEKKYLTATQNTKNGVDVLPKIIQTVGGGAVQERAPELDGGGPTEQDKS
Sbjct: 301 VVFIKWIVTFFLEKKYLTATQNTKNGVDVLPKIIQTVGGGAVQERAPELDGGGPTEQDKS 360
Query: 361 HSNSSTLSDRRLSNSSLCSIEEEHRMVYEMVQRILLSTRGYVNFVNEVFHQAFLLPSCEI 420
HSNSSTLSDRRLSNSSLCSIEEEHRMVYEMVQRILLSTRGYVNFVNEVFHQAFLLPSCEI
Sbjct: 361 HSNSSTLSDRRLSNSSLCSIEEEHRMVYEMVQRILLSTRGYVNFVNEVFHQAFLLPSCEI 420
Query: 421 AVTRKVVQVYRKWILQDKPVFMEEPDRKDVAQEDAEKLGFSETDSKEASSESSGHKRSSS 480
AVTRKVVQVYRKWILQDKPVFMEEPDRKDVAQEDAEKLGFSETDSKEASSESSGHKRSSS
Sbjct: 421 AVTRKVVQVYRKWILQDKPVFMEEPDRKDVAQEDAEKLGFSETDSKEASSESSGHKRSSS 480
Query: 481 WGRTYSFTSAMSRGCVTEEENTNVKAGVQALLQVFLTNSANIFLLEPCAEVPVLLKEQVD 540
WGRTYSFTSAMSRGCVTEEENTNVKAGVQALLQVFLTNSANIFLLEPCAEVPVLLKEQVD
Sbjct: 481 WGRTYSFTSAMSRGCVTEEENTNVKAGVQALLQVFLTNSANIFLLEPCAEVPVLLKEQVD 540
Query: 541 ACKAVLIIFRRMIMELTMNKKTWEQMLQILLRITEAVMQKPKDKQIKDLFAQSLAGLLFR 600
ACKAVLIIFRRMIMELTMNKKTWEQMLQILLRITEAVMQKPKDKQIKDLFAQSLAGLLFR
Sbjct: 541 ACKAVLIIFRRMIMELTMNKKTWEQMLQILLRITEAVMQKPKDKQIKDLFAQSLAGLLFR 600
Query: 601 TLMVAWIRANLCVYISRELWDDFLGVLSSLTEWEELINEWANIMDSLTAVLARTVYGVEM 660
TLMVAWIRANLCVYISRELWDDFLGVLSSLTEWEELINEWANIMDSLTAVLARTVYGVEM
Sbjct: 601 TLMVAWIRANLCVYISRELWDDFLGVLSSLTEWEELINEWANIMDSLTAVLARTVYGVEM 660
Query: 661 TNLPLDKLSEQKEKKQRGKGCVLDPQKGTTVGRSFSLSWRSHPDVTEPMRFRSATTSGAP 720
TNLPLDKLSEQKEKKQRGKGCVLDPQKGTTVGRSFSLSWRSHPDVTEPMRFRSATTSGAP
Sbjct: 661 TNLPLDKLSEQKEKKQRGKGCVLDPQKGTTVGRSFSLSWRSHPDVTEPMRFRSATTSGAP 720
Query: 721 GVEKARNIVRQKATEVEECQQSENAPAAGSGHLTVGQQQQVLRSSSTSDIPEPLCSDSSQ 780
GVEKARNIVRQKATEVEECQQSENAPAAGSGHLTVGQQQQVLRSSSTSDIPEPLCSDSSQ
Sbjct: 721 GVEKARNIVRQKATEVEECQQSENAPAAGSGHLTVGQQQQVLRSSSTSDIPEPLCSDSSQ 780
Query: 781 GQKAENTQNSSSSEPQPIQENKGHVKREHEGITILVRRSSSPAELDLKDDLQQTQGKCRE 840
GQKAENTQNSSSSEPQPIQENKGHVKREHEGITILVRRSSSPAELDLKDDLQQTQGKCRE
Sbjct: 781 GQKAENTQNSSSSEPQPIQENKGHVKREHEGITILVRRSSSPAELDLKDDLQQTQGKCRE 840
Query: 841 RQKSESTNSDTTLGCTNEAELSMGPWQTCEEDPELNTPTDVVADADARHWLQLSPTDASN 900
RQKSESTNSDTTLGCTNEAELSMGPWQTCEEDPELNTPTDVVADADARHWLQLSPTDASN
Sbjct: 841 RQKSESTNSDTTLGCTNEAELSMGPWQTCEEDPELNTPTDVVADADARHWLQLSPTDASN 900
Query: 901 LTDSSECLTDDCSIIAGGSLTGWHPDSAAVLWRRVLGILGDVNNIQSPKIHARVFCYLYE 960
LTDSSECLTDDCSIIAGGSLTGWHPDSAAVLWRRVLGILGDVNNIQSPKIHARVFCYLYE
Sbjct: 901 LTDSSECLTDDCSIIAGGSLTGWHPDSAAVLWRRVLGILGDVNNIQSPKIHARVFCYLYE 960
Query: 961 LWYKLAKIRDNLAISLDNQSSPSPPVLIPPLRMFASWLFKAATLPNEYKEGKLQAYRLIC 1020
LWYKLAKIRDNLAISLDNQSSPSPPVLIPPLRMFASWLFKAATLPNEYKEGKLQAYRLIC
Sbjct: 961 LWYKLAKIRDNLAISLDNQSSPSPPVLIPPLRMFASWLFKAATLPNEYKEGKLQAYRLIC 1020
Query: 1021 AMMTRRQDVLPNSDFLVHFYLVMHLGLTSEDQDILNTIIRHCPPRFFSLGFPGFSMLVGD 1080
AMMTRRQDVLPNSDFLVHFYLVMHLGLTSEDQDILNTIIRHCPPRFFSLGFPGFSMLVGD
Sbjct: 1021 AMMTRRQDVLPNSDFLVHFYLVMHLGLTSEDQDILNTIIRHCPPRFFSLGFPGFSMLVGD 1080
Query: 1081 FITAAARVLSTDILTAPRSEAVTVLGSLVCFPNTYQEIPLLQSVPEVNEAITGTEDVKHY 1140
FITAAARVLSTDILTAPRSEAVTVLGSLVCFPNTYQEIPLLQSVPEVNEAITGTEDVKHY
Sbjct: 1081 FITAAARVLSTDILTAPRSEAVTVLGSLVCFPNTYQEIPLLQSVPEVNEAITGTEDVKHY 1140
Query: 1141 LINILLKNATEEPNEYARCIAVCSLGVWICEELAQCTSHPQVKEAINVIGVTLKFPNKIV 1200
LINILLKNATEEPNEYARCIAVCSLGVWICEELAQCTSHPQVKEAINVIGVTLKFPNKIV
Sbjct: 1141 LINILLKNATEEPNEYARCIAVCSLGVWICEELAQCTSHPQVKEAINVIGVTLKFPNKIV 1200
Query: 1201 AQVACDVLQLLVSYWEKLQMFETSLPRKMAEILVATVAFLLPSAEYSSVETDKKFIVSLL 1260
AQVACDVLQLLVSYWEKLQMFETSLPRKMAEILVATVAFLLPSAEYSSVETDKKFIVSLL
Sbjct: 1201 AQVACDVLQLLVSYWEKLQMFETSLPRKMAEILVATVAFLLPSAEYSSVETDKKFIVSLL 1260
Query: 1261 LCLLDWCMALPVSVLLHPVSTAVLEEQHSARAPLLDYIYRVLHCCVCGSSTYTQQSHYIL 1320
LCLLDWCMALPVSVLLHPVSTAVLEEQHSARAPLLDYIYRVLHCCVCGSSTYTQQSHYIL
Sbjct: 1261 LCLLDWCMALPVSVLLHPVSTAVLEEQHSARAPLLDYIYRVLHCCVCGSSTYTQQSHYIL 1320
Query: 1321 TLADLSSTDYDPFLPLANVKSSEPVQYHSSAELGNLLTVEEEKKRRSLELIPLTARMVMA 1380
TLADLSSTDYDPFLPLANVKSSEPVQYHSSAELGNLLTVEEEKKRRSLELIPLTARMVMA
Sbjct: 1321 TLADLSSTDYDPFLPLANVKSSEPVQYHSSAELGNLLTVEEEKKRRSLELIPLTARMVMA 1380
Query: 1381 HLVNHLGHYPLSGGPAILHSLVSENHDNAHVEGSELSFEVFRSPNLQLFVFNDSTLISYL 1440
HLVNHLGHYPLSGGPAILHSLVSENHDNAHVEGSELSFEVFRSPNLQLFVFNDSTLISYL
Sbjct: 1381 HLVNHLGHYPLSGGPAILHSLVSENHDNAHVEGSELSFEVFRSPNLQLFVFNDSTLISYL 1440
Query: 1441 QTPTEGPVGGSPVGSLSDVRVIVRDISGKYSWDGKVLYGPLEGCLAPNGRNPSFLISSWH 1500
QTPTEGPVGGSPVGSLSDVRVIVRDISGKYSWDGKVLYGPLEGCLAPNGRNPSFLISSWH
Sbjct: 1441 QTPTEGPVGGSPVGSLSDVRVIVRDISGKYSWDGKVLYGPLEGCLAPNGRNPSFLISSWH 1500
Query: 1501 RDTFGPQKDSSQVEEGDDVLDKLLENIGHTSPECLLPSQLNLNEPSLTPCGMNYDQEKEI 1560
RDTFGPQKDSSQVEEGDDVLDKLLENIGHTSPECLLPSQLNLNEPSLTPCGMNYDQEKEI
Sbjct: 1501 RDTFGPQKDSSQVEEGDDVLDKLLENIGHTSPECLLPSQLNLNEPSLTPCGMNYDQEKEI 1560
Query: 1561 IEVILRQNAQEDEYIQSHNFDSAMKVTSQGQPSPVEPRGPFYFCRLLLDDLGMNSWDRRK 1620
IEVILRQNAQEDEYIQSHNFDSAMKVTSQGQPSPVEPRGPFYFCRLLLDDLGMNSWDRRK
Sbjct: 1561 IEVILRQNAQEDEYIQSHNFDSAMKVTSQGQPSPVEPRGPFYFCRLLLDDLGMNSWDRRK 1620
Query: 1621 NFHLLKKNSKLLRELKNLDSRQCRETHKIAVFYIAEGQEDKCSILSNERGSQAYEDFVAG 1680
NFHLLKKNSKLLRELKNLDSRQCRETHKIAVFYIAEGQEDKCSILSNERGSQAYEDFVAG
Sbjct: 1621 NFHLLKKNSKLLRELKNLDSRQCRETHKIAVFYIAEGQEDKCSILSNERGSQAYEDFVAG 1680
Query: 1681 LGWEVDLSTHCGFMGGLQRNGSTGQTAPYYATSTVEVIFHVSTRMPSDSDDSLTKKLRHL 1740
LGWEVDLSTHCGFMGGLQRNGSTGQTAPYYATSTVEVIFHVSTRMPSDSDDSLTKKLRHL
Sbjct: 1681 LGWEVDLSTHCGFMGGLQRNGSTGQTAPYYATSTVEVIFHVSTRMPSDSDDSLTKKLRHL 1740
Query: 1741 GNDEVHIVWSEHSRDYRRGIIPTAFGDVSIIIYPMKNHMFFIAITKKPEVPFFGPLFDGA 1800
GNDEVHIVWSEHSRDYRRGIIPTAFGDVSIIIYPMKNHMFFIAITKKPEVPFFGPLFDGA
Sbjct: 1741 GNDEVHIVWSEHSRDYRRGIIPTAFGDVSIIIYPMKNHMFFIAITKKPEVPFFGPLFDGA 1800
Query: 1801 IVSGKLLPSLVCATCINASRAVKCLIPLYQSFYEERALYLEAIIQNHREVMTFEDFAAQV 1860
IVSGKLLPSLVCATCINASRAVKCLIPLYQSFYEERALYLEAIIQNHREVMTFEDFAAQV
Sbjct: 1801 IVSGKLLPSLVCATCINASRAVKCLIPLYQSFYEERALYLEAIIQNHREVMTFEDFAAQV 1860
Query: 1861 FSPSPSYSLSGTD 1873
FSPSPSYSLSGTD
Sbjct: 1861 FSPSPSYSLSGTD 1873
>gi|51230412 GTPase activating Rap/RanGAP domain-like 1 isoform 2
[Homo sapiens]
Length = 2083
Score = 1148 bits (2970), Expect = 0.0
Identities = 589/1025 (57%), Positives = 737/1025 (71%), Gaps = 46/1025 (4%)
Query: 880 DVVADADARHWLQLSPTDASNLTDSSECLTDDCSIIAGGSLTGWHPDSAAVLWRRVLGIL 939
D+ D H + +P D SEC CS++AGG+LTGWH D A V+WRR+LGIL
Sbjct: 1017 DLQLDEKLHHSVLQTPDDLEISEFPSEC----CSVMAGGTLTGWHADVATVMWRRMLGIL 1072
Query: 940 GDVNNIQSPKIHARVFCYLYELWYKLAKIRDNLAISLDNQSSPSPPVLIPPLRMFASWLF 999
GDVN+I P+IHA+VF YL ELW LAKIRDNL IS DN +SPSPPVLIPPLR+ WLF
Sbjct: 1073 GDVNSIMDPEIHAQVFDYLCELWQNLAKIRDNLGISTDNLTSPSPPVLIPPLRILTPWLF 1132
Query: 1000 KAATLPNEYKEGKLQAYRLICAMMTRRQDVLPNSDFLVHFYLVMHLGLTSEDQDILNTII 1059
KA L ++YK+GKL AY+LIC M RRQDV PN DFL HFY +MH GL DQDI+NTII
Sbjct: 1133 KATMLTDKYKQGKLHAYKLICNTMKRRQDVSPNRDFLTHFYNIMHCGLLHIDQDIVNTII 1192
Query: 1060 RHCPPRFFSLGFPGFSMLVGDFITAAARVLSTDILTAPRSEAVTVLGSLVCFPNTYQEIP 1119
+HC P+FFSLG PG +ML+ DFI AA RV S+ L APR EA +LGSLVCFPN Y E+P
Sbjct: 1193 KHCSPQFFSLGLPGATMLIMDFIVAAGRVASSAFLNAPRVEAQVLLGSLVCFPNLYCELP 1252
Query: 1120 LLQ-SVPEVNEAITGTEDVKHYLINILLKNATEEPNEYARCIAVCSLGVWICEELAQCTS 1178
L ++P+V A++ DVK +I +L +A +EP+ ARC+A+CSLG+WICEEL +
Sbjct: 1253 SLHPNIPDV--AVSQFTDVKELIIKTVLSSARDEPSGPARCVALCSLGIWICEELVHESH 1310
Query: 1179 HPQVKEAINVIGVTLKFPNKIVAQVACDVLQLLVSYWEKLQMFETSLPRKMAEILVATVA 1238
HPQ+KEA+NVI V+LKF NK VA VAC++L +LV Y +LQ+++ P K+ +IL+AT+
Sbjct: 1311 HPQIKEALNVICVSLKFTNKTVAHVACNMLHMLVHYVPRLQIYQPDSPLKIIQILIATIT 1370
Query: 1239 FLLPSAEYSSVETDKKFIVSLLLCLLDWCMALPVSVLLHPVSTAVLEEQHSARAPLLDYI 1298
LLPS E SS E DK+ +VSLLLCLLDW MALP+ LL P E + ++ +L+ I
Sbjct: 1371 HLLPSTEASSYEMDKRLVVSLLLCLLDWIMALPLKTLLQPFHATGAESDKTEKS-VLNCI 1429
Query: 1299 YRVLHCCVCGSSTYTQQSHYILTLADLSSTDYDPFLPLANVKSSEPVQYHSSAELGNLLT 1358
Y+VLH CV G+ ++ ++ ++L+DL+S DYDPF+ L ++K EP+ S L
Sbjct: 1430 YKVLHGCVYGAQCFSNPRYFPMSLSDLASVDYDPFMHLESLKEPEPLHSPDSERSSKLQP 1489
Query: 1359 VEEEKKRRSLELIPLTARMVMAHLVNHLGHYPLSGGPAILHSLVSENHDNAHVEGSELSF 1418
V E K + LI + AR V+ HLVNHLGHYP+SGGPA+L S V ENHDN + E +ELS
Sbjct: 1490 VTEVKTQMQHGLISIAARTVITHLVNHLGHYPMSGGPAMLTSQVCENHDNHYSESTELSP 1549
Query: 1419 EVFRSPNLQLFVFNDSTLISYLQTPTEG--PVGGSPVG---SLSDVRVIVRDISGKYSWD 1473
E+F SPN+Q FV N++TL+S +Q +E P GG G + S+VR+IVRD+SGKYSWD
Sbjct: 1550 ELFESPNIQFFVLNNTTLVSCIQIRSEENMPGGGLSAGLASANSNVRIIVRDLSGKYSWD 1609
Query: 1474 GKVLYG--PLEGCLAPNGRNPSFLISSWHRDTFGPQKDSSQ------------------- 1512
+LYG P+ G P SF++S H++ S++
Sbjct: 1610 SAILYGPPPVSGLSEPT----SFMLSLSHQEKPEEPPTSNECLEDITVKDGLSLQFKRFR 1665
Query: 1513 --------VEEGDDVLDKLLENIGHTSPECLLPSQLNLNEPSLTPCGMNYDQEKEIIEVI 1564
+ + +DVLD+LL+ +G TSPECL + ++LN P+ P ++ QE ++I I
Sbjct: 1666 ETVPTWDTIRDEEDVLDELLQYLGVTSPECLQRTGISLNIPAPQPVCISEKQENDVINAI 1725
Query: 1565 LRQNAQEDEYIQSHNFDSAMKVTSQGQPSPVEPRGPFYFCRLLLDDLGMNSWDRRKNFHL 1624
L+Q+ +E E+++ H D MK Q +P P +P+ FY+CRLLL LGMNSWD+R++FHL
Sbjct: 1726 LKQHTEEKEFVEKHFNDLNMKAVEQDEPIPQKPQSAFYYCRLLLSILGMNSWDKRRSFHL 1785
Query: 1625 LKKNSKLLRELKNLDSRQCRETHKIAVFYIAEGQEDKCSILSNERGSQAYEDFVAGLGWE 1684
LKKN KLLREL+NLDSRQCRETHKIAVFY+AEGQEDK SIL+N GSQAYEDFVAGLGWE
Sbjct: 1786 LKKNEKLLRELRNLDSRQCRETHKIAVFYVAEGQEDKHSILTNTGGSQAYEDFVAGLGWE 1845
Query: 1685 VDLSTHCGFMGGLQRNGSTGQTAPYYATSTVEVIFHVSTRMPSDSDDSLTKKLRHLGNDE 1744
V+L+ HCGFMGGLQ+N STG T PY+ATSTVEVIFHVSTRMPSDSDDSLTKKLRHLGNDE
Sbjct: 1846 VNLTNHCGFMGGLQKNKSTGLTTPYFATSTVEVIFHVSTRMPSDSDDSLTKKLRHLGNDE 1905
Query: 1745 VHIVWSEHSRDYRRGIIPTAFGDVSIIIYPMKNHMFFIAITKKPEVPFFGPLFDGAIVSG 1804
VHIVWSEH+RDYRRGIIPT FGDV I+IYPMKNHMF I I KKPEVPFFGPLFDGAIV+G
Sbjct: 1906 VHIVWSEHTRDYRRGIIPTEFGDVLIVIYPMKNHMFSIQIMKKPEVPFFGPLFDGAIVNG 1965
Query: 1805 KLLPSLVCATCINASRAVKCLIPLYQSFYEERALYLEAIIQNHREVMTFEDFAAQVFSPS 1864
K+LP +V AT INASRA+K LIPLYQ+FYEERA YL+ I+Q+H E TFEDFAAQVFSP+
Sbjct: 1966 KVLPIMVRATAINASRALKSLIPLYQNFYEERARYLQTIVQHHLEPTTFEDFAAQVFSPA 2025
Query: 1865 PSYSL 1869
P + L
Sbjct: 2026 PYHHL 2030
Score = 799 bits (2064), Expect = 0.0
Identities = 439/889 (49%), Positives = 586/889 (65%), Gaps = 64/889 (7%)
Query: 1 MFSRRSHGDVKKSTQKVLDPKKDVLTRLKHLRALLDNVDANDLKQFFETNYSQIYFIFYE 60
MFS++ HGDVKKSTQKVLD KKD LTRLKHLR +++N ++ DLKQFF+ ++S IY++F+E
Sbjct: 1 MFSKKPHGDVKKSTQKVLDTKKDALTRLKHLRIVIENAESIDLKQFFDQHFSHIYYVFFE 60
Query: 61 NFIALENSLKLKGNNKSQREELDSILFLFEKILQFLPERIFFRWHYQSIGSTLKKLLHTG 120
NF+ +E SLK KG+ KSQREELD+ILF+FEKILQ LPERI RW + SIG LKKLLHTG
Sbjct: 61 NFVTIEASLKQKGH-KSQREELDAILFIFEKILQLLPERIHQRWQFHSIGLILKKLLHTG 119
Query: 121 NSIKIRCEGIRLFLLWLQALQTNCAEEQVLIFACLVPGFPAVMSSRGPCTLETLINPSPS 180
NS+KIR EG+RLFLLWLQALQ NC++EQ+ +F+CL+PGF A S GP TL+ LINP +
Sbjct: 120 NSLKIRREGVRLFLLWLQALQNNCSKEQLWMFSCLIPGFSAPQSEHGPRTLDNLINPPLN 179
Query: 181 VADVKIYPEEITPLLPAISGEKIAEDQTCFFLQILLKYMVIQAASLEWKNKENQDTGFKF 240
+ + ++ EEITPL+P SG+K ED T +FL+ LLKY+VIQ SLEWKNKENQ+ GF F
Sbjct: 180 LQETQVTIEEITPLVPPQSGDKGQEDLTSYFLEALLKYIVIQVKSLEWKNKENQERGFSF 239
Query: 241 LFTLFRKYYLPHLFPSFTKLTNIYKPVLDIPHLRPKPVYITTTRD---NENIYSTKIPYM 297
LF+ F+KYYLP++FP+ K ++Y P+LDIP +RPKP Y+ +D NE IY TK P++
Sbjct: 240 LFSHFKKYYLPYIFPNICKENSLYHPILDIPQMRPKPHYVVIKKDAETNEAIYCTKEPFI 299
Query: 298 AARVVFIKWIVTFFLEKKYLTATQNTKNGVDVLPKIIQTVGGGAVQERAPELDGGG---- 353
ARV+ I+W+V+F+LE K T +VLPK IQ V + D
Sbjct: 300 KARVIVIRWLVSFWLEPKPHTGPHIPGMEGEVLPKNIQRAAASLVSREESKNDNADKTDR 359
Query: 354 PTEQDKSHSNSSTLSDRRLSNSSLCSIEEEHRMVYEMVQRILLSTRGYVNFVNEVFHQAF 413
TE ++SHSN+STL++R S+SSLCSI+EEH E+V+R+ S R VNFV E+F QAF
Sbjct: 360 TTEPEQSHSNTSTLTEREPSSSSLCSIDEEHLTDIEIVRRVFSSKRSNVNFVTEIFRQAF 419
Query: 414 LLPSCEIAVTRKVVQVYRKWILQ-DKPVFMEEPDR----------------KDVAQEDAE 456
LLP CE A RKVV+VY++WI Q +KP+FM+EP+ D++ E+ E
Sbjct: 420 LLPICEAAAMRKVVKVYQEWIQQEEKPLFMQEPEEIVITSSDLPCIENVTDHDISMEEGE 479
Query: 457 KLGFSETDSKEASSESSGHKRSSSWGRTYSFTSAMSRGCVTEEENTNVKAGVQALLQVFL 516
K +E + ++ H R+SSW + S+ A+ E N++AG QA+LQVF+
Sbjct: 480 K------REEENGTNTADHVRNSSWAKNGSYQGAL-HNASEEATEQNIRAGTQAVLQVFI 532
Query: 517 TNSANIFLLEPCAEVPVLLKEQVDACKAVLIIFRRMIMELTMNKKTWEQMLQILLRITEA 576
NS+NIFLLEP E+ LL E D CK +L I+R M+++++M+KKTWEQML +LLR+TE+
Sbjct: 533 INSSNIFLLEPANEIKNLLDEHTDMCKRILNIYRYMVVQVSMDKKTWEQMLLVLLRVTES 592
Query: 577 VMQKPKDKQIK------DLFAQSLAGLLFRTLMVAWIRANLCVYISRELWDDFLGVLSSL 630
V++ P ++ A LAG LF+TL+VAWI+ANL VYISRELWDD L VLSSL
Sbjct: 593 VLKMPSQAFLQFQGKKNMTLAGRLAGPLFQTLIVAWIKANLNVYISRELWDDLLSVLSSL 652
Query: 631 TEWEELINEWANIMDSLTAVLARTVYGVEMTNLPLDKLSEQKEKKQRGKGCVLDPQKGTT 690
T WEEL EW+ M++LT VLAR +Y +++++LPLDKLSEQK+KK +GKG + QK +
Sbjct: 653 TYWEELATEWSLTMETLTKVLARNLYSLDLSDLPLDKLSEQKQKKHKGKGVGHEFQK-VS 711
Query: 691 VGRSFSLSWRSHPDVTEPMRFRSATTSGAPGVEKARNIVRQKATEVEECQ---------- 740
V +SFS W PMR RSATT+G+PG EKAR+IVRQK ++++ Q
Sbjct: 712 VDKSFSRGWSRDQPGQAPMRQRSATTTGSPGTEKARSIVRQKTVDIDDAQILPRSTRVRH 771
Query: 741 --QSENAPAAGSGHLTVGQQQQVLRSSSTSDIPEPLCSDSSQGQKAENTQ---------- 788
QSE G L ++Q + RSSSTSDI EP + ++ K + +Q
Sbjct: 772 FSQSEETGNEVFGAL--NEEQPLPRSSSTSDILEPFTVERAKVNKEDMSQKLPPLNSDIG 829
Query: 789 NSSSSEPQPIQENKGHVKREHEGITILVRRSSSPAELDLKDDLQQTQGK 837
SS++ P + E R T + RR SSP L++ DL K
Sbjct: 830 GSSANVPDLMDEFIAERLRSGNAST-MTRRGSSPGSLEIPKDLPDILNK 877
>gi|51226124 GTPase activating Rap/RanGAP domain-like 1 isoform 1
[Homo sapiens]
Length = 2036
Score = 1148 bits (2970), Expect = 0.0
Identities = 589/1025 (57%), Positives = 737/1025 (71%), Gaps = 46/1025 (4%)
Query: 880 DVVADADARHWLQLSPTDASNLTDSSECLTDDCSIIAGGSLTGWHPDSAAVLWRRVLGIL 939
D+ D H + +P D SEC CS++AGG+LTGWH D A V+WRR+LGIL
Sbjct: 1017 DLQLDEKLHHSVLQTPDDLEISEFPSEC----CSVMAGGTLTGWHADVATVMWRRMLGIL 1072
Query: 940 GDVNNIQSPKIHARVFCYLYELWYKLAKIRDNLAISLDNQSSPSPPVLIPPLRMFASWLF 999
GDVN+I P+IHA+VF YL ELW LAKIRDNL IS DN +SPSPPVLIPPLR+ WLF
Sbjct: 1073 GDVNSIMDPEIHAQVFDYLCELWQNLAKIRDNLGISTDNLTSPSPPVLIPPLRILTPWLF 1132
Query: 1000 KAATLPNEYKEGKLQAYRLICAMMTRRQDVLPNSDFLVHFYLVMHLGLTSEDQDILNTII 1059
KA L ++YK+GKL AY+LIC M RRQDV PN DFL HFY +MH GL DQDI+NTII
Sbjct: 1133 KATMLTDKYKQGKLHAYKLICNTMKRRQDVSPNRDFLTHFYNIMHCGLLHIDQDIVNTII 1192
Query: 1060 RHCPPRFFSLGFPGFSMLVGDFITAAARVLSTDILTAPRSEAVTVLGSLVCFPNTYQEIP 1119
+HC P+FFSLG PG +ML+ DFI AA RV S+ L APR EA +LGSLVCFPN Y E+P
Sbjct: 1193 KHCSPQFFSLGLPGATMLIMDFIVAAGRVASSAFLNAPRVEAQVLLGSLVCFPNLYCELP 1252
Query: 1120 LLQ-SVPEVNEAITGTEDVKHYLINILLKNATEEPNEYARCIAVCSLGVWICEELAQCTS 1178
L ++P+V A++ DVK +I +L +A +EP+ ARC+A+CSLG+WICEEL +
Sbjct: 1253 SLHPNIPDV--AVSQFTDVKELIIKTVLSSARDEPSGPARCVALCSLGIWICEELVHESH 1310
Query: 1179 HPQVKEAINVIGVTLKFPNKIVAQVACDVLQLLVSYWEKLQMFETSLPRKMAEILVATVA 1238
HPQ+KEA+NVI V+LKF NK VA VAC++L +LV Y +LQ+++ P K+ +IL+AT+
Sbjct: 1311 HPQIKEALNVICVSLKFTNKTVAHVACNMLHMLVHYVPRLQIYQPDSPLKIIQILIATIT 1370
Query: 1239 FLLPSAEYSSVETDKKFIVSLLLCLLDWCMALPVSVLLHPVSTAVLEEQHSARAPLLDYI 1298
LLPS E SS E DK+ +VSLLLCLLDW MALP+ LL P E + ++ +L+ I
Sbjct: 1371 HLLPSTEASSYEMDKRLVVSLLLCLLDWIMALPLKTLLQPFHATGAESDKTEKS-VLNCI 1429
Query: 1299 YRVLHCCVCGSSTYTQQSHYILTLADLSSTDYDPFLPLANVKSSEPVQYHSSAELGNLLT 1358
Y+VLH CV G+ ++ ++ ++L+DL+S DYDPF+ L ++K EP+ S L
Sbjct: 1430 YKVLHGCVYGAQCFSNPRYFPMSLSDLASVDYDPFMHLESLKEPEPLHSPDSERSSKLQP 1489
Query: 1359 VEEEKKRRSLELIPLTARMVMAHLVNHLGHYPLSGGPAILHSLVSENHDNAHVEGSELSF 1418
V E K + LI + AR V+ HLVNHLGHYP+SGGPA+L S V ENHDN + E +ELS
Sbjct: 1490 VTEVKTQMQHGLISIAARTVITHLVNHLGHYPMSGGPAMLTSQVCENHDNHYSESTELSP 1549
Query: 1419 EVFRSPNLQLFVFNDSTLISYLQTPTEG--PVGGSPVG---SLSDVRVIVRDISGKYSWD 1473
E+F SPN+Q FV N++TL+S +Q +E P GG G + S+VR+IVRD+SGKYSWD
Sbjct: 1550 ELFESPNIQFFVLNNTTLVSCIQIRSEENMPGGGLSAGLASANSNVRIIVRDLSGKYSWD 1609
Query: 1474 GKVLYG--PLEGCLAPNGRNPSFLISSWHRDTFGPQKDSSQ------------------- 1512
+LYG P+ G P SF++S H++ S++
Sbjct: 1610 SAILYGPPPVSGLSEPT----SFMLSLSHQEKPEEPPTSNECLEDITVKDGLSLQFKRFR 1665
Query: 1513 --------VEEGDDVLDKLLENIGHTSPECLLPSQLNLNEPSLTPCGMNYDQEKEIIEVI 1564
+ + +DVLD+LL+ +G TSPECL + ++LN P+ P ++ QE ++I I
Sbjct: 1666 ETVPTWDTIRDEEDVLDELLQYLGVTSPECLQRTGISLNIPAPQPVCISEKQENDVINAI 1725
Query: 1565 LRQNAQEDEYIQSHNFDSAMKVTSQGQPSPVEPRGPFYFCRLLLDDLGMNSWDRRKNFHL 1624
L+Q+ +E E+++ H D MK Q +P P +P+ FY+CRLLL LGMNSWD+R++FHL
Sbjct: 1726 LKQHTEEKEFVEKHFNDLNMKAVEQDEPIPQKPQSAFYYCRLLLSILGMNSWDKRRSFHL 1785
Query: 1625 LKKNSKLLRELKNLDSRQCRETHKIAVFYIAEGQEDKCSILSNERGSQAYEDFVAGLGWE 1684
LKKN KLLREL+NLDSRQCRETHKIAVFY+AEGQEDK SIL+N GSQAYEDFVAGLGWE
Sbjct: 1786 LKKNEKLLRELRNLDSRQCRETHKIAVFYVAEGQEDKHSILTNTGGSQAYEDFVAGLGWE 1845
Query: 1685 VDLSTHCGFMGGLQRNGSTGQTAPYYATSTVEVIFHVSTRMPSDSDDSLTKKLRHLGNDE 1744
V+L+ HCGFMGGLQ+N STG T PY+ATSTVEVIFHVSTRMPSDSDDSLTKKLRHLGNDE
Sbjct: 1846 VNLTNHCGFMGGLQKNKSTGLTTPYFATSTVEVIFHVSTRMPSDSDDSLTKKLRHLGNDE 1905
Query: 1745 VHIVWSEHSRDYRRGIIPTAFGDVSIIIYPMKNHMFFIAITKKPEVPFFGPLFDGAIVSG 1804
VHIVWSEH+RDYRRGIIPT FGDV I+IYPMKNHMF I I KKPEVPFFGPLFDGAIV+G
Sbjct: 1906 VHIVWSEHTRDYRRGIIPTEFGDVLIVIYPMKNHMFSIQIMKKPEVPFFGPLFDGAIVNG 1965
Query: 1805 KLLPSLVCATCINASRAVKCLIPLYQSFYEERALYLEAIIQNHREVMTFEDFAAQVFSPS 1864
K+LP +V AT INASRA+K LIPLYQ+FYEERA YL+ I+Q+H E TFEDFAAQVFSP+
Sbjct: 1966 KVLPIMVRATAINASRALKSLIPLYQNFYEERARYLQTIVQHHLEPTTFEDFAAQVFSPA 2025
Query: 1865 PSYSL 1869
P + L
Sbjct: 2026 PYHHL 2030
Score = 799 bits (2064), Expect = 0.0
Identities = 439/889 (49%), Positives = 586/889 (65%), Gaps = 64/889 (7%)
Query: 1 MFSRRSHGDVKKSTQKVLDPKKDVLTRLKHLRALLDNVDANDLKQFFETNYSQIYFIFYE 60
MFS++ HGDVKKSTQKVLD KKD LTRLKHLR +++N ++ DLKQFF+ ++S IY++F+E
Sbjct: 1 MFSKKPHGDVKKSTQKVLDTKKDALTRLKHLRIVIENAESIDLKQFFDQHFSHIYYVFFE 60
Query: 61 NFIALENSLKLKGNNKSQREELDSILFLFEKILQFLPERIFFRWHYQSIGSTLKKLLHTG 120
NF+ +E SLK KG+ KSQREELD+ILF+FEKILQ LPERI RW + SIG LKKLLHTG
Sbjct: 61 NFVTIEASLKQKGH-KSQREELDAILFIFEKILQLLPERIHQRWQFHSIGLILKKLLHTG 119
Query: 121 NSIKIRCEGIRLFLLWLQALQTNCAEEQVLIFACLVPGFPAVMSSRGPCTLETLINPSPS 180
NS+KIR EG+RLFLLWLQALQ NC++EQ+ +F+CL+PGF A S GP TL+ LINP +
Sbjct: 120 NSLKIRREGVRLFLLWLQALQNNCSKEQLWMFSCLIPGFSAPQSEHGPRTLDNLINPPLN 179
Query: 181 VADVKIYPEEITPLLPAISGEKIAEDQTCFFLQILLKYMVIQAASLEWKNKENQDTGFKF 240
+ + ++ EEITPL+P SG+K ED T +FL+ LLKY+VIQ SLEWKNKENQ+ GF F
Sbjct: 180 LQETQVTIEEITPLVPPQSGDKGQEDLTSYFLEALLKYIVIQVKSLEWKNKENQERGFSF 239
Query: 241 LFTLFRKYYLPHLFPSFTKLTNIYKPVLDIPHLRPKPVYITTTRD---NENIYSTKIPYM 297
LF+ F+KYYLP++FP+ K ++Y P+LDIP +RPKP Y+ +D NE IY TK P++
Sbjct: 240 LFSHFKKYYLPYIFPNICKENSLYHPILDIPQMRPKPHYVVIKKDAETNEAIYCTKEPFI 299
Query: 298 AARVVFIKWIVTFFLEKKYLTATQNTKNGVDVLPKIIQTVGGGAVQERAPELDGGG---- 353
ARV+ I+W+V+F+LE K T +VLPK IQ V + D
Sbjct: 300 KARVIVIRWLVSFWLEPKPHTGPHIPGMEGEVLPKNIQRAAASLVSREESKNDNADKTDR 359
Query: 354 PTEQDKSHSNSSTLSDRRLSNSSLCSIEEEHRMVYEMVQRILLSTRGYVNFVNEVFHQAF 413
TE ++SHSN+STL++R S+SSLCSI+EEH E+V+R+ S R VNFV E+F QAF
Sbjct: 360 TTEPEQSHSNTSTLTEREPSSSSLCSIDEEHLTDIEIVRRVFSSKRSNVNFVTEIFRQAF 419
Query: 414 LLPSCEIAVTRKVVQVYRKWILQ-DKPVFMEEPDR----------------KDVAQEDAE 456
LLP CE A RKVV+VY++WI Q +KP+FM+EP+ D++ E+ E
Sbjct: 420 LLPICEAAAMRKVVKVYQEWIQQEEKPLFMQEPEEIVITSSDLPCIENVTDHDISMEEGE 479
Query: 457 KLGFSETDSKEASSESSGHKRSSSWGRTYSFTSAMSRGCVTEEENTNVKAGVQALLQVFL 516
K +E + ++ H R+SSW + S+ A+ E N++AG QA+LQVF+
Sbjct: 480 K------REEENGTNTADHVRNSSWAKNGSYQGAL-HNASEEATEQNIRAGTQAVLQVFI 532
Query: 517 TNSANIFLLEPCAEVPVLLKEQVDACKAVLIIFRRMIMELTMNKKTWEQMLQILLRITEA 576
NS+NIFLLEP E+ LL E D CK +L I+R M+++++M+KKTWEQML +LLR+TE+
Sbjct: 533 INSSNIFLLEPANEIKNLLDEHTDMCKRILNIYRYMVVQVSMDKKTWEQMLLVLLRVTES 592
Query: 577 VMQKPKDKQIK------DLFAQSLAGLLFRTLMVAWIRANLCVYISRELWDDFLGVLSSL 630
V++ P ++ A LAG LF+TL+VAWI+ANL VYISRELWDD L VLSSL
Sbjct: 593 VLKMPSQAFLQFQGKKNMTLAGRLAGPLFQTLIVAWIKANLNVYISRELWDDLLSVLSSL 652
Query: 631 TEWEELINEWANIMDSLTAVLARTVYGVEMTNLPLDKLSEQKEKKQRGKGCVLDPQKGTT 690
T WEEL EW+ M++LT VLAR +Y +++++LPLDKLSEQK+KK +GKG + QK +
Sbjct: 653 TYWEELATEWSLTMETLTKVLARNLYSLDLSDLPLDKLSEQKQKKHKGKGVGHEFQK-VS 711
Query: 691 VGRSFSLSWRSHPDVTEPMRFRSATTSGAPGVEKARNIVRQKATEVEECQ---------- 740
V +SFS W PMR RSATT+G+PG EKAR+IVRQK ++++ Q
Sbjct: 712 VDKSFSRGWSRDQPGQAPMRQRSATTTGSPGTEKARSIVRQKTVDIDDAQILPRSTRVRH 771
Query: 741 --QSENAPAAGSGHLTVGQQQQVLRSSSTSDIPEPLCSDSSQGQKAENTQ---------- 788
QSE G L ++Q + RSSSTSDI EP + ++ K + +Q
Sbjct: 772 FSQSEETGNEVFGAL--NEEQPLPRSSSTSDILEPFTVERAKVNKEDMSQKLPPLNSDIG 829
Query: 789 NSSSSEPQPIQENKGHVKREHEGITILVRRSSSPAELDLKDDLQQTQGK 837
SS++ P + E R T + RR SSP L++ DL K
Sbjct: 830 GSSANVPDLMDEFIAERLRSGNAST-MTRRGSSPGSLEIPKDLPDILNK 877
>gi|116256350 tuberous sclerosis 2 isoform 4 [Homo sapiens]
Length = 1740
Score = 101 bits (251), Expect = 8e-21
Identities = 66/211 (31%), Positives = 108/211 (51%), Gaps = 7/211 (3%)
Query: 1617 DRRKNFHLLKKNSKLLRELKNLDSRQCRETHKIAVFYIAEGQED-KCSILSNERGSQAYE 1675
+ K L ++ R ++ LD +THKIAV Y+ EGQ + + +ILSNE GS Y
Sbjct: 1446 ESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYT 1505
Query: 1676 DFVAGLGWEVDLSTHCG----FMGGLQRNGSTGQTAPYYATSTVEVIFHVSTRMPS-DSD 1730
+F+ GLG ++L C ++GGL G GQ + ++ +FH++T MP+ D D
Sbjct: 1506 EFLTGLGRLIELKD-CQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVD 1564
Query: 1731 DSLTKKLRHLGNDEVHIVWSEHSRDYRRGIIPTAFGDVSIIIYPMKNHMFFIAITKKPEV 1790
K RHLGND V IV+++ D++ G I F V +I+ P+ +++ + ++
Sbjct: 1565 KHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDM 1624
Query: 1791 PFFGPLFDGAIVSGKLLPSLVCATCINASRA 1821
IVS + LP + ++A+ A
Sbjct: 1625 EGLVDTSVAKIVSDRNLPFVARQMALHANMA 1655
>gi|116256352 tuberous sclerosis 2 isoform 1 [Homo sapiens]
Length = 1807
Score = 101 bits (251), Expect = 8e-21
Identities = 66/211 (31%), Positives = 108/211 (51%), Gaps = 7/211 (3%)
Query: 1617 DRRKNFHLLKKNSKLLRELKNLDSRQCRETHKIAVFYIAEGQED-KCSILSNERGSQAYE 1675
+ K L ++ R ++ LD +THKIAV Y+ EGQ + + +ILSNE GS Y
Sbjct: 1513 ESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYT 1572
Query: 1676 DFVAGLGWEVDLSTHCG----FMGGLQRNGSTGQTAPYYATSTVEVIFHVSTRMPS-DSD 1730
+F+ GLG ++L C ++GGL G GQ + ++ +FH++T MP+ D D
Sbjct: 1573 EFLTGLGRLIELKD-CQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVD 1631
Query: 1731 DSLTKKLRHLGNDEVHIVWSEHSRDYRRGIIPTAFGDVSIIIYPMKNHMFFIAITKKPEV 1790
K RHLGND V IV+++ D++ G I F V +I+ P+ +++ + ++
Sbjct: 1632 KHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDM 1691
Query: 1791 PFFGPLFDGAIVSGKLLPSLVCATCINASRA 1821
IVS + LP + ++A+ A
Sbjct: 1692 EGLVDTSVAKIVSDRNLPFVARQMALHANMA 1722
>gi|167412124 tuberous sclerosis 2 isoform 5 [Homo sapiens]
Length = 1784
Score = 101 bits (251), Expect = 8e-21
Identities = 66/211 (31%), Positives = 108/211 (51%), Gaps = 7/211 (3%)
Query: 1617 DRRKNFHLLKKNSKLLRELKNLDSRQCRETHKIAVFYIAEGQED-KCSILSNERGSQAYE 1675
+ K L ++ R ++ LD +THKIAV Y+ EGQ + + +ILSNE GS Y
Sbjct: 1490 ESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYT 1549
Query: 1676 DFVAGLGWEVDLSTHCG----FMGGLQRNGSTGQTAPYYATSTVEVIFHVSTRMPS-DSD 1730
+F+ GLG ++L C ++GGL G GQ + ++ +FH++T MP+ D D
Sbjct: 1550 EFLTGLGRLIELKD-CQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVD 1608
Query: 1731 DSLTKKLRHLGNDEVHIVWSEHSRDYRRGIIPTAFGDVSIIIYPMKNHMFFIAITKKPEV 1790
K RHLGND V IV+++ D++ G I F V +I+ P+ +++ + ++
Sbjct: 1609 KHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDM 1668
Query: 1791 PFFGPLFDGAIVSGKLLPSLVCATCINASRA 1821
IVS + LP + ++A+ A
Sbjct: 1669 EGLVDTSVAKIVSDRNLPFVARQMALHANMA 1699
>gi|224809582 RAP1 GTPase activating protein isoform c [Homo sapiens]
Length = 663
Score = 81.6 bits (200), Expect = 6e-15
Identities = 62/234 (26%), Positives = 107/234 (45%), Gaps = 19/234 (8%)
Query: 1630 KLLRELKNLDSRQCRETHKIAVFYIAEGQEDKCSILSNERGSQAYEDFVAGLGWEVDLST 1689
K R + D K V Y GQ + + S S A+ +F+ LG +V L
Sbjct: 176 KASRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQD 235
Query: 1690 HCGFMGGLQ-RNGSTGQTAPYYATSTVEVIFHVSTRMP-SDSDDSLTKKLRHLGNDEVHI 1747
GF GGL +G TG + Y E++FHVST++P ++ D ++ RH+GND V +
Sbjct: 236 FKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAV 295
Query: 1748 VWSEHSRDYRRGIIPTAFGDVSIIIYP----MKNHMFFIAITKKPEVPFFGPLFDGAIVS 1803
V+ + + + +I + F +++ ++ +++T + +VPFFGP V
Sbjct: 296 VFQDENTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVF 355
Query: 1804 GK-------LLPSLVCA--TCINASRAVK----CLIPLYQSFYEERALYLEAII 1844
K LL L+ A C A + K L ++ YEE ++ ++++
Sbjct: 356 RKGPEFQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMM 409
>gi|224809578 RAP1 GTPase activating protein isoform a [Homo sapiens]
Length = 727
Score = 81.6 bits (200), Expect = 6e-15
Identities = 62/234 (26%), Positives = 107/234 (45%), Gaps = 19/234 (8%)
Query: 1630 KLLRELKNLDSRQCRETHKIAVFYIAEGQEDKCSILSNERGSQAYEDFVAGLGWEVDLST 1689
K R + D K V Y GQ + + S S A+ +F+ LG +V L
Sbjct: 240 KASRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQD 299
Query: 1690 HCGFMGGLQ-RNGSTGQTAPYYATSTVEVIFHVSTRMP-SDSDDSLTKKLRHLGNDEVHI 1747
GF GGL +G TG + Y E++FHVST++P ++ D ++ RH+GND V +
Sbjct: 300 FKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAV 359
Query: 1748 VWSEHSRDYRRGIIPTAFGDVSIIIYP----MKNHMFFIAITKKPEVPFFGPLFDGAIVS 1803
V+ + + + +I + F +++ ++ +++T + +VPFFGP V
Sbjct: 360 VFQDENTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVF 419
Query: 1804 GK-------LLPSLVCA--TCINASRAVK----CLIPLYQSFYEERALYLEAII 1844
K LL L+ A C A + K L ++ YEE ++ ++++
Sbjct: 420 RKGPEFQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMM 473
>gi|224809573 RAP1 GTPase activating protein isoform b [Homo sapiens]
Length = 681
Score = 81.6 bits (200), Expect = 6e-15
Identities = 62/234 (26%), Positives = 107/234 (45%), Gaps = 19/234 (8%)
Query: 1630 KLLRELKNLDSRQCRETHKIAVFYIAEGQEDKCSILSNERGSQAYEDFVAGLGWEVDLST 1689
K R + D K V Y GQ + + S S A+ +F+ LG +V L
Sbjct: 176 KASRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQD 235
Query: 1690 HCGFMGGLQ-RNGSTGQTAPYYATSTVEVIFHVSTRMP-SDSDDSLTKKLRHLGNDEVHI 1747
GF GGL +G TG + Y E++FHVST++P ++ D ++ RH+GND V +
Sbjct: 236 FKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAV 295
Query: 1748 VWSEHSRDYRRGIIPTAFGDVSIIIYP----MKNHMFFIAITKKPEVPFFGPLFDGAIVS 1803
V+ + + + +I + F +++ ++ +++T + +VPFFGP V
Sbjct: 296 VFQDENTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVF 355
Query: 1804 GK-------LLPSLVCA--TCINASRAVK----CLIPLYQSFYEERALYLEAII 1844
K LL L+ A C A + K L ++ YEE ++ ++++
Sbjct: 356 RKGPEFQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMM 409
>gi|207448705 GTPase activating Rap/RanGAP domain-like 3 [Homo
sapiens]
Length = 1013
Score = 77.4 bits (189), Expect = 1e-13
Identities = 55/197 (27%), Positives = 102/197 (51%), Gaps = 13/197 (6%)
Query: 1607 LLDDLGMNSWDR--RKNFHLLKKNSKLLRELKNLDSRQCRETHKIAVFYIAEGQEDKCSI 1664
+L + ++ +++ R+ FH ++ ++L L+ ++ K V + +GQ +
Sbjct: 166 ILSAMNLDKFEKGPREIFH-----PEIQKDLLVLEEQEGSVNFKFGVLFAKDGQLTDDEM 220
Query: 1665 LSNERGSQAYEDFVAGLGWEVDLSTHCGFMGGLQ-RNGSTGQTAPYYATSTVEVIFHVST 1723
SNE GS+ ++ F+ LG + L G+ GGL +N +TG + Y E++FHVST
Sbjct: 221 FSNEIGSEPFQKFLNLLGDTITLKGWTGYRGGLDTKNDTTGIHSVYTVYQGHEIMFHVST 280
Query: 1724 RMP-SDSDDSLTKKLRHLGNDEVHIVW---SEHSRDYRRGIIPTAFGDV-SIIIYPMKNH 1778
+P S + ++ RH+GND V IV+ E S ++ +I + F + +++ Y +N
Sbjct: 281 MLPYSKENKQQVERKRHIGNDIVTIVFQEGEESSPAFKPSMIRSHFTHIFALVRYNQQND 340
Query: 1779 MFFIAITKKPEVPFFGP 1795
+ + I + VP FGP
Sbjct: 341 NYRLKIFSEESVPLFGP 357
>gi|156086740 GTPase activating Rap/RanGAP domain-like 4 isoform 2
[Homo sapiens]
Length = 715
Score = 77.0 bits (188), Expect = 2e-13
Identities = 49/172 (28%), Positives = 85/172 (49%), Gaps = 6/172 (3%)
Query: 1630 KLLRELKNLDSRQCRETHKIAVFYIAEGQEDKCSILSNERGSQAYEDFVAGLGWEVDLST 1689
K + + + D + T K V Y Q + + N S A+++F+ LG + L
Sbjct: 228 KASQMIVSYDEHEVNNTFKFGVIYQKARQTLEEELFGNNEESPAFKEFLDLLGDTITLQD 287
Query: 1690 HCGFMGGLQ-RNGSTGQTAPYYATSTVEVIFHVSTRMP-SDSDDSLTKKLRHLGNDEVHI 1747
GF GGL +G TG + Y E++FHVST++P +D D ++ RH+GND V I
Sbjct: 288 FKGFRGGLDVTHGQTGVESVYTTFRDREIMFHVSTKLPFTDGDAQQLQRKRHIGNDIVAI 347
Query: 1748 VWSEHSRDYRRGIIPTAFGDVSIIIY----PMKNHMFFIAITKKPEVPFFGP 1795
++ E + + +I + F I++ + + +++T + +VP FGP
Sbjct: 348 IFQEENTPFVPDMIASNFLHAYIVVQVETPGTETPSYKVSVTAREDVPTFGP 399
Score = 32.7 bits (73), Expect = 3.4
Identities = 40/146 (27%), Positives = 58/146 (39%), Gaps = 16/146 (10%)
Query: 756 GQQQQVLRSSSTSDIPE-PLCSDSSQGQKAENTQNSSSSEPQPIQENKGHVKREHEGITI 814
GQ R STS P+ P SSQ K+E + N SS E P +E K +K + G I
Sbjct: 561 GQGDSRARCDSTSSTPKTPDGGHSSQEIKSETSSNPSSPEICPNKE-KPFMKLKENGRAI 619
Query: 815 LVRRSSSPAELDLKDDLQQTQGKCRERQKSESTNSDTTLGCTNEAELSMGPWQTCEEDPE 874
RSSS + T G+ ++ +S S + + E+ + E P
Sbjct: 620 --SRSSSST-----SSVSSTAGEGEAMEEGDSGGSQPSTTSPFKQEVFVYSPSPSSESPS 672
Query: 875 LNTPTDVVADADARHWLQLSPTDASN 900
L + + SPTDA +
Sbjct: 673 LGAAATPII-------MSRSPTDAKS 691
>gi|156086724 GTPase activating Rap/RanGAP domain-like 4 isoform 1
[Homo sapiens]
Length = 730
Score = 77.0 bits (188), Expect = 2e-13
Identities = 49/172 (28%), Positives = 85/172 (49%), Gaps = 6/172 (3%)
Query: 1630 KLLRELKNLDSRQCRETHKIAVFYIAEGQEDKCSILSNERGSQAYEDFVAGLGWEVDLST 1689
K + + + D + T K V Y Q + + N S A+++F+ LG + L
Sbjct: 243 KASQMIVSYDEHEVNNTFKFGVIYQKARQTLEEELFGNNEESPAFKEFLDLLGDTITLQD 302
Query: 1690 HCGFMGGLQ-RNGSTGQTAPYYATSTVEVIFHVSTRMP-SDSDDSLTKKLRHLGNDEVHI 1747
GF GGL +G TG + Y E++FHVST++P +D D ++ RH+GND V I
Sbjct: 303 FKGFRGGLDVTHGQTGVESVYTTFRDREIMFHVSTKLPFTDGDAQQLQRKRHIGNDIVAI 362
Query: 1748 VWSEHSRDYRRGIIPTAFGDVSIIIY----PMKNHMFFIAITKKPEVPFFGP 1795
++ E + + +I + F I++ + + +++T + +VP FGP
Sbjct: 363 IFQEENTPFVPDMIASNFLHAYIVVQVETPGTETPSYKVSVTAREDVPTFGP 414
Score = 32.7 bits (73), Expect = 3.4
Identities = 40/146 (27%), Positives = 58/146 (39%), Gaps = 16/146 (10%)
Query: 756 GQQQQVLRSSSTSDIPE-PLCSDSSQGQKAENTQNSSSSEPQPIQENKGHVKREHEGITI 814
GQ R STS P+ P SSQ K+E + N SS E P +E K +K + G I
Sbjct: 576 GQGDSRARCDSTSSTPKTPDGGHSSQEIKSETSSNPSSPEICPNKE-KPFMKLKENGRAI 634
Query: 815 LVRRSSSPAELDLKDDLQQTQGKCRERQKSESTNSDTTLGCTNEAELSMGPWQTCEEDPE 874
RSSS + T G+ ++ +S S + + E+ + E P
Sbjct: 635 --SRSSSST-----SSVSSTAGEGEAMEEGDSGGSQPSTTSPFKQEVFVYSPSPSSESPS 687
Query: 875 LNTPTDVVADADARHWLQLSPTDASN 900
L + + SPTDA +
Sbjct: 688 LGAAATPII-------MSRSPTDAKS 706
>gi|71143119 signal-induced proliferation-associated 1 like 3 [Homo
sapiens]
Length = 1781
Score = 73.9 bits (180), Expect = 1e-12
Identities = 64/239 (26%), Positives = 106/239 (44%), Gaps = 14/239 (5%)
Query: 1621 NFHLLK---KNSKLLRELKNLDSRQCRETHKIAVFYIAEGQEDKCSILSNERGSQAYEDF 1677
N H L+ K+ +L LD + HK+ + Y GQ + + +NE A+E+F
Sbjct: 594 NIHCLRLALNTPKVTEQLLKLDEQGLCRKHKVGILYCKAGQSSEEEMYNNEEAGPAFEEF 653
Query: 1678 VAGLGWEVDLSTHCGFMGGLQ-RNGSTGQTAPYYATSTVEVIFHVSTRMP--SDSDDSLT 1734
++ +G +V L + L + STG + Y E++FHVST +P ++ L
Sbjct: 654 LSLIGEKVCLKGFTKYAAQLDVKTDSTGTHSLYTMYQDYEIMFHVSTLLPYTPNNRQQLL 713
Query: 1735 KKLRHLGNDEVHIVWSE-HSRDYRRGIIPTAFGDVSIIIYP----MKNHMFFIAITKKPE 1789
+K RH+GND V I++ E + + I + F V II+ N + +A+T+ +
Sbjct: 714 RK-RHIGNDIVTIIFQEPGALPFTPKNIRSHFQHVFIIVRVHNPCTDNVCYSMAVTRSKD 772
Query: 1790 VPFFGPLFDGAIVSGK--LLPSLVCATCINASRAVKCLIPLYQSFYEERALYLEAIIQN 1846
P FGP K + + A INA A + R YL+ + +N
Sbjct: 773 APPFGPPIPSGTTFRKSDVFRDFLLAKVINAENAAHKSDKFHTMATRTRQEYLKDLAEN 831
>gi|7662126 signal-induced proliferation-associated 1 like 1 [Homo
sapiens]
Length = 1804
Score = 71.2 bits (173), Expect = 9e-12
Identities = 58/202 (28%), Positives = 96/202 (47%), Gaps = 11/202 (5%)
Query: 1630 KLLRELKNLDSRQCRETHKIAVFYIAEGQEDKCSILSNERGSQAYEDFVAGLGWEVDLST 1689
K+ +L LD + K+ + Y GQ + + +NE A+E+F+ LG V L
Sbjct: 594 KVTEQLMKLDEQGLNYQQKVGIMYCKAGQSTEEEMYNNESAGPAFEEFLQLLGERVRLKG 653
Query: 1690 HCGFMGGLQ-RNGSTGQTAPYYATSTVEVIFHVSTRMP--SDSDDSLTKKLRHLGNDEVH 1746
+ L + STG + Y E++FHVST +P ++ L +K RH+GND V
Sbjct: 654 FEKYRAQLDTKTDSTGTHSLYTTYKDYEIMFHVSTMLPYTPNNKQQLLRK-RHIGNDIVT 712
Query: 1747 IVWSE-HSRDYRRGIIPTAFGDVSIII---YPMKNHM-FFIAITKKPEVPFFGPLFDGAI 1801
IV+ E ++ + I + F V +I+ P + + + +A+T+ +VP FGP +
Sbjct: 713 IVFQEPGAQPFSPKNIRSHFQHVFVIVRVHNPCSDSVCYSVAVTRSRDVPSFGPPIPKGV 772
Query: 1802 VSGK--LLPSLVCATCINASRA 1821
K + + A INA A
Sbjct: 773 TFPKSNVFRDFLLAKVINAENA 794
>gi|112421013 signal-induced proliferation-associated 1 like 2 [Homo
sapiens]
Length = 1722
Score = 70.5 bits (171), Expect = 1e-11
Identities = 62/227 (27%), Positives = 101/227 (44%), Gaps = 11/227 (4%)
Query: 1630 KLLRELKNLDSRQCRETHKIAVFYIAEGQEDKCSILSNERGSQAYEDFVAGLGWEVDLST 1689
K+ +L LD + HKI + Y GQ + + +NE A+E+F+ LG V L
Sbjct: 590 KVSEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKG 649
Query: 1690 HCGFMGGL-QRNGSTGQTAPYYATSTVEVIFHVSTRMP--SDSDDSLTKKLRHLGNDEVH 1746
+ L + STG + Y E++FHVST +P ++ L +K RH+GND V
Sbjct: 650 FSKYRAQLDNKTDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRK-RHIGNDIVT 708
Query: 1747 IVWSE-HSRDYRRGIIPTAFGDVSIIIYP----MKNHMFFIAITKKPEVPFFGPLFDGAI 1801
IV+ E + + I + F V +I+ +N + + +++ +VP FGP +
Sbjct: 709 IVFQEPGALPFTPKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGV 768
Query: 1802 VSGK--LLPSLVCATCINASRAVKCLIPLYQSFYEERALYLEAIIQN 1846
K + + A INA A R YL+ + +N
Sbjct: 769 TFPKSAVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAEN 815
>gi|206725526 signal-induced proliferation-associated protein 1 [Homo
sapiens]
Length = 1042
Score = 64.3 bits (155), Expect = 1e-09
Identities = 65/247 (26%), Positives = 108/247 (43%), Gaps = 15/247 (6%)
Query: 1630 KLLRELKNLDSRQCRETHKIAVFYIAEGQEDKCSILSNERGSQAYEDFVAGLGWEVDLST 1689
K+ R L LD + K+ + Y GQ + + +N+ A+ F+ LG V L
Sbjct: 316 KVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAFMQFLTLLGDVVRLKG 375
Query: 1690 HCGFMGGLQ-RNGSTGQTAPYYATSTVEVIFHVSTRMP--SDSDDSLTKKLRHLGNDEVH 1746
+ L + STG + Y E++FHVST +P ++ L +K RH+GND V
Sbjct: 376 FESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRK-RHIGNDIVT 434
Query: 1747 IVWSE-HSRDYRRGIIPTAFGDVSIII---YPMKNHMFF-IAITKKPEVPFFGPLF---D 1798
IV+ E S+ + I + F V +++ P H + +A+++ + P FGP
Sbjct: 435 IVFQEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRTQDTPAFGPALPAGG 494
Query: 1799 GAIVSGKLLPSLVCATCINASRAVKCLIPLYQSFYEERALYLEAIIQNHREVMTFE-DFA 1857
G + + + A +N +A + R YL+ + N EV T D A
Sbjct: 495 GPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDLATN--EVTTTSLDSA 552
Query: 1858 AQVFSPS 1864
++ PS
Sbjct: 553 SRFGLPS 559
>gi|206725523 signal-induced proliferation-associated protein 1 [Homo
sapiens]
Length = 1042
Score = 64.3 bits (155), Expect = 1e-09
Identities = 65/247 (26%), Positives = 108/247 (43%), Gaps = 15/247 (6%)
Query: 1630 KLLRELKNLDSRQCRETHKIAVFYIAEGQEDKCSILSNERGSQAYEDFVAGLGWEVDLST 1689
K+ R L LD + K+ + Y GQ + + +N+ A+ F+ LG V L
Sbjct: 316 KVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAFMQFLTLLGDVVRLKG 375
Query: 1690 HCGFMGGLQ-RNGSTGQTAPYYATSTVEVIFHVSTRMP--SDSDDSLTKKLRHLGNDEVH 1746
+ L + STG + Y E++FHVST +P ++ L +K RH+GND V
Sbjct: 376 FESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRK-RHIGNDIVT 434
Query: 1747 IVWSE-HSRDYRRGIIPTAFGDVSIII---YPMKNHMFF-IAITKKPEVPFFGPLF---D 1798
IV+ E S+ + I + F V +++ P H + +A+++ + P FGP
Sbjct: 435 IVFQEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRTQDTPAFGPALPAGG 494
Query: 1799 GAIVSGKLLPSLVCATCINASRAVKCLIPLYQSFYEERALYLEAIIQNHREVMTFE-DFA 1857
G + + + A +N +A + R YL+ + N EV T D A
Sbjct: 495 GPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDLATN--EVTTTSLDSA 552
Query: 1858 AQVFSPS 1864
++ PS
Sbjct: 553 SRFGLPS 559
>gi|34787409 hypothetical protein LOC57148 [Homo sapiens]
Length = 1494
Score = 62.4 bits (150), Expect = 4e-09
Identities = 86/359 (23%), Positives = 141/359 (39%), Gaps = 68/359 (18%)
Query: 1375 ARMVMAHLVNHLGHYPLSGGPAILHSLVSENHDNAHVEGSELSFEVFRSPNLQLFVFNDS 1434
A + ++ LG +P GPA SLV+E ++ S L + + FV ++S
Sbjct: 899 AEATLTCIMQLLGAFPSPSGPASPCSLVNET---TLIKYSRLP--TINKHSFRYFVLDNS 953
Query: 1435 TLISYLQTPTEGPVGGSPVGSLSDVRVIVRDISGKYSWDGKVLYGPLEGCLAPNGRNPS- 1493
+++ L E P+G V V+VR +SG+ +W ++ CL P G +
Sbjct: 954 VILAML----EQPLGNEQNDFFPSVTVLVRGMSGRLAWAQQL-------CLLPRGAKANQ 1002
Query: 1494 ----------------FLISSWHRDTFGPQKDSSQVEEGDDVLDKLLENIGHTSPECLLP 1537
F S HR F + D + D + L E ++
Sbjct: 1003 KLFVPEPRPVPKNDVGFKYSVKHRP-FPEEVDKIPFVKADLSIPDLHE---------IVT 1052
Query: 1538 SQLNLNEPSLTPCGMNYDQEKEIIEVILRQNAQEDEYIQSHNFDSAMKVTSQGQPSPVEP 1597
+L L GM ++ E+ L Q ++E+ +Q +F VT P P +
Sbjct: 1053 EELEERHEKLRS-GM---AQQIAYEIHLEQQSEEE--LQKRSFPDP--VTDCKPPPPAQE 1104
Query: 1598 RGPFYFCRLLLDDLGMNSWDRRKNF-------HLLKKNSKL---LRELKNLDSRQCRETH 1647
F RL L G S + K HL+ +S + ++ LD CR
Sbjct: 1105 ---FQTARLFLSHFGFLSLEALKEPANSRLPPHLIALDSTIPGFFDDIGYLDLLPCRPFD 1161
Query: 1648 KIAVFYIAEGQEDKCSILSNERGSQAYE----DFVAGLGWEVDLSTHCGFMGGLQRNGS 1702
+ +FY+ GQ+ IL N S+ + +F+ LGW VD+ H G+ G + + S
Sbjct: 1162 TVFIFYMKPGQKTNQEILKNVESSRTVQPHFLEFLLSLGWSVDVGRHPGWTGHVSTSWS 1220
Score = 47.0 bits (110), Expect = 2e-04
Identities = 29/121 (23%), Positives = 60/121 (49%), Gaps = 4/121 (3%)
Query: 538 QVDACKAVLIIFRRMIMELT-MNKKTWEQMLQILLRITEAVMQKPKDKQIKDLFAQSLAG 596
Q+ C VL +++ E + M ++TWE +L LL+I + ++ P ++ A++LA
Sbjct: 137 QIRLCLQVLRAIQKLARESSLMARETWEVLLLFLLQINDILLAPPT---VQGGIAENLAE 193
Query: 597 LLFRTLMVAWIRANLCVYISRELWDDFLGVLSSLTEWEELINEWANIMDSLTAVLARTVY 656
L L W+ A + + W ++++ ++ +W+ ++ +LT+ L R Y
Sbjct: 194 KLIGVLFEVWLLACTRCFPTPPYWKTAKEMVANWRHHPAVVEQWSKVICALTSRLLRFTY 253
Query: 657 G 657
G
Sbjct: 254 G 254
>gi|108773787 retinoblastoma 1 [Homo sapiens]
Length = 928
Score = 37.0 bits (84), Expect = 0.18
Identities = 22/61 (36%), Positives = 31/61 (50%), Gaps = 1/61 (1%)
Query: 1234 VATVAFLLPSAEYSSVETDKKFIVSLLLCLLDWCMAL-PVSVLLHPVSTAVLEEQHSARA 1292
V+ + FLL E +E D L+LC+LD+ + L P +L P TAV+ S R
Sbjct: 193 VSWITFLLAKGEVLQMEDDLVISFQLMLCVLDYFIKLSPPMLLKEPYKTAVIPINGSPRT 252
Query: 1293 P 1293
P
Sbjct: 253 P 253
>gi|122937211 KIAA0368 protein [Homo sapiens]
Length = 2017
Score = 35.0 bits (79), Expect = 0.69
Identities = 30/103 (29%), Positives = 49/103 (47%), Gaps = 17/103 (16%)
Query: 1202 QVACDVLQLLVSYWEKLQMFETSL--PRKMAEILVAT---VAFLLPSAEYSSVETDKKFI 1256
+V VLQ + ++++ L + E P +AEIL+ T + + L + YSSV T+ +
Sbjct: 1903 KVQLGVLQSMNAFFQGLMLLEEEHADPEALAEILLETCKSITYSLENKTYSSVRTEALSV 1962
Query: 1257 VSLLL----------CLLDWCMALPVSVL--LHPVSTAVLEEQ 1287
+ LLL CL C L + L + P S L+E+
Sbjct: 1963 IELLLKKLEESKQWECLTSECRVLLIESLATMEPDSRPELQEK 2005
>gi|28460688 taxilin [Homo sapiens]
Length = 546
Score = 33.9 bits (76), Expect = 1.5
Identities = 42/171 (24%), Positives = 63/171 (36%), Gaps = 14/171 (8%)
Query: 721 GVEKARNIVRQKATEVE-ECQQSENAPAAGSGHLTVGQQQQVLR------SSSTSDIPEP 773
G E A+ Q A VE E S AP G Q LR S DI
Sbjct: 26 GPEGAQERPSQAAPAVEAEGPGSSQAPRKPEGAQARTAQSGALRDVSEELSRQLEDILST 85
Query: 774 LCSDSSQGQKAENTQNSSSSEPQPIQENKGHVKREHE-GITILVRRSSSPAELDLKDDLQ 832
C D++QG E+ +EP+ ++++ +V R E T +V P++ D +
Sbjct: 86 YCVDNNQGGPGEDGAQGEPAEPEDAEKSRTYVARNGEPEPTPVVNGEKEPSKGDPNTEEI 145
Query: 833 QTQGKCRERQKSESTNSDTTLGCTNEAELSMGPWQTCEEDPELNTPTDVVA 883
+ + +R G E L M T L+TP + +A
Sbjct: 146 RQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNT------LSTPEEKLA 190
>gi|7661950 SH2 domain binding protein 1 [Homo sapiens]
Length = 1173
Score = 33.9 bits (76), Expect = 1.5
Identities = 32/130 (24%), Positives = 46/130 (35%), Gaps = 17/130 (13%)
Query: 730 RQKATEVEECQQSENAPAAGSGHLTVGQQQQVLRSSSTSDIPEPLCSDSSQGQKAENTQN 789
++K E EN +GS G ++ R S D SDS Q +
Sbjct: 1048 QRKKCASSESDSDENQNKSGS---EAGSPRRPRRQRSDQD------SDSDQPSRKRRPSG 1098
Query: 790 SSSSEPQPIQENKGHVKREHEGITILVRRSSSPAELDLKDDLQQTQGKCRERQKSESTNS 849
S S+ + +Q R H G++ S PA + D + +G E S N
Sbjct: 1099 SEQSDNESVQSG-----RSHSGVS---ENDSRPASPSAESDHESERGSDNEGSGQGSGNE 1150
Query: 850 DTTLGCTNEA 859
G NEA
Sbjct: 1151 SEPEGSNNEA 1160
>gi|171184451 centrosome-associated protein 350 [Homo sapiens]
Length = 3117
Score = 33.9 bits (76), Expect = 1.5
Identities = 23/77 (29%), Positives = 36/77 (46%), Gaps = 5/77 (6%)
Query: 407 EVFHQAFLLPSCEIAVTRKVVQVYRKWILQDKPVFMEEPDRKDVAQEDAEKLGF---SET 463
E F + +P E + TR++ + Y K +L+ +EEP + V QE K G+ E+
Sbjct: 638 EAFTKVKNVPPSEPSATRRLQETYSKLLLE--KTLLEEPSHQHVTQETQAKPGYQPSGES 695
Query: 464 DSKEASSESSGHKRSSS 480
D + E SSS
Sbjct: 696 DKENKVQERPPSASSSS 712
>gi|155969714 nuclear protein, ataxia-telangiectasia locus [Homo
sapiens]
Length = 1427
Score = 33.1 bits (74), Expect = 2.6
Identities = 30/112 (26%), Positives = 49/112 (43%), Gaps = 19/112 (16%)
Query: 701 SHPDVTEPMRFRSATTSGAPGVEKAR---NIVRQKATEVEECQ-----QSENAPAA-GSG 751
S+ V + F + +S + V K++ N++ +++ CQ QSE P + S
Sbjct: 554 SNDTVKLKINFHGSKSSDSSEVHKSKIEINVLEPVMSQLSNCQDNSCLQSEILPVSVESS 613
Query: 752 HLTVGQQQQVLRSSSTSDIPEPLCSDSS----------QGQKAENTQNSSSS 793
HL V Q ++ S S +P +S Q K+EN+Q SSS
Sbjct: 614 HLNVSGQVEIHLGDSLSSTKQPSNDSASVELNHTENEAQASKSENSQEPSSS 665
>gi|40538728 pleckstrin homology domain containing, family M (with
RUN domain) member 1 [Homo sapiens]
Length = 1056
Score = 32.7 bits (73), Expect = 3.4
Identities = 25/88 (28%), Positives = 40/88 (45%), Gaps = 10/88 (11%)
Query: 765 SSTSDIPEPLCSDSSQGQKAENTQNSSS-SEPQPIQENKGHVKREHEGITILVRRSSSPA 823
S ++IP P S S G + + +EP P Q G +G+ + R +P+
Sbjct: 327 SQETEIPTPQASLSLHGLNTSTYLHCEAPAEPLPAQAASG----TQDGVHVQEPRPQAPS 382
Query: 824 ELDLKDDLQQTQGKCRERQKSESTNSDT 851
LDL+ ++ T G Q+ ST S+T
Sbjct: 383 PLDLQQPVESTSG-----QQPSSTVSET 405
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 32.7 bits (73), Expect = 3.4
Identities = 34/165 (20%), Positives = 67/165 (40%), Gaps = 6/165 (3%)
Query: 764 SSSTSDIPEPLCSDSSQGQKAENTQNSSSSEPQPIQENKGHVKREHEGITILVRRSSSPA 823
SS +SD + SDSS + N+ NSS S+ ++ + SS +
Sbjct: 698 SSESSDSSDSSDSDSSDSSDSSNS-NSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSS 756
Query: 824 ELDLKDDLQQTQGKCRERQKSESTNSDTTLGCTNEAELSMGPWQTCEEDPELNTPTDVVA 883
+ + + S+S+NS + +N ++ S + + ++ + +
Sbjct: 757 DSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSS 816
Query: 884 DADARHWLQLSPTDASNLTDSSECLTDDCSIIAGGSLTGWHPDSA 928
D+D+ + +D+SN +DSS+ S + S G DS+
Sbjct: 817 DSDSS-----NSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSS 856
Score = 32.3 bits (72), Expect = 4.5
Identities = 27/143 (18%), Positives = 57/143 (39%), Gaps = 2/143 (1%)
Query: 764 SSSTSDIPEPLCSDSSQGQKAENTQNSSSSEPQPIQENKGHVKREHEGITILVRRSSSPA 823
SS +SD + SDSS + N+ +SS S + + + SS+ +
Sbjct: 806 SSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSS 865
Query: 824 ELDLKDDLQQTQGKCRERQKSESTNSDTTLGCTNEAELSMGPWQTCEEDPELNTPTDVVA 883
+ D + +ES+NS + +N ++ + + + +D
Sbjct: 866 DSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSE 925
Query: 884 DADARHWLQLSPTDASNLTDSSE 906
+++ + +D+SN +DSS+
Sbjct: 926 SSNSSD--NSNSSDSSNSSDSSD 946
Score = 32.0 bits (71), Expect = 5.8
Identities = 35/165 (21%), Positives = 66/165 (40%), Gaps = 13/165 (7%)
Query: 764 SSSTSDIPEPLCSDSSQGQKAENTQNSSSSEPQPIQENKGHVKREHEGITILVRRSSSPA 823
SS +SD + SDSS + N+ +SS S + +E SS +
Sbjct: 841 SSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNES-----SNSSDSS 895
Query: 824 ELDLKDDLQQTQGKCRERQKSESTNSDTTLGCTNEAELSMGPWQTCEEDPELNTPTDVVA 883
+ D + S+S+NS + +N ++ S + D ++ + +
Sbjct: 896 DSSNSSD-SDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSS 954
Query: 884 DADARHWLQLSPTDASNLTDSSECLTDDCSIIAGGSLTGWHPDSA 928
D+ + +D+SN +DSS+ + D S + S + DS+
Sbjct: 955 DSS-------NSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSS 992
>gi|51873049 hypothetical protein LOC8603 [Homo sapiens]
Length = 1224
Score = 32.7 bits (73), Expect = 3.4
Identities = 27/131 (20%), Positives = 54/131 (41%), Gaps = 2/131 (1%)
Query: 706 TEPMRFRSATTSGAPGVEKARNIVRQKATEVEECQQSENAPAAGSGHLTVGQQQQVLRSS 765
+EP R + G K R KA V+ +E + ++Q+
Sbjct: 1057 SEPARRPTEPPKATEGQSKPRAQTESKAKVVDLMSITEQKREERKVNSNNNNKKQLNHIK 1116
Query: 766 STSDIPEPLCSDSSQGQKAENTQNSSSSEPQPIQENKGHVKREHEGITILVRRSSSPAEL 825
P P+ +S G+ +N++ + PQP +NK + K++ + + + P ++
Sbjct: 1117 DEKSNPTPM-EPTSPGEHQQNSKLVLAESPQPKGKNKKNKKKKGDRVNNSIDDVFLPKDI 1175
Query: 826 DLKD-DLQQTQ 835
DL D+ +T+
Sbjct: 1176 DLDSVDMDETE 1186
>gi|33356174 pinin, desmosome associated protein [Homo sapiens]
Length = 717
Score = 32.7 bits (73), Expect = 3.4
Identities = 37/159 (23%), Positives = 60/159 (37%), Gaps = 17/159 (10%)
Query: 703 PDVTEPMRFRSATTSGAPGVEKARNIVRQKATEVEECQQSENAPAAGSGHLTVGQQQQVL 762
P +T +S T + + +ARN + + S ++ + S +
Sbjct: 544 PVLTVHPESKSKTKTRSRSRGRARNKTSKSRSRSSSSSSSSSSSTSSSSGSSSSSGSSSS 603
Query: 763 RSSSTSDIPEPLCSDSSQGQKAENTQNSSSSEPQPIQENKGHVK-REHEGITILVRRSSS 821
RSSS+S S S + ++ SSSSE + +GH + R+H RR +S
Sbjct: 604 RSSSSSS-----SSTSGSSSRDSSSSTSSSSESRSRSRGRGHNRDRKHRRSVDRKRRDTS 658
Query: 822 PAEL-----------DLKDDLQQTQGKCRERQKSESTNS 849
E D K + R+R SES+ S
Sbjct: 659 GLERSHKSSKGGSSRDTKGSKDKNSRSDRKRSISESSRS 697
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 32.7 bits (73), Expect = 3.4
Identities = 51/226 (22%), Positives = 83/226 (36%), Gaps = 36/226 (15%)
Query: 669 SEQKEKKQRGKGCVLDPQKGTTVGRSFSLSWRSHPDVTEPMRFRSATTSGAPGVEKA--R 726
S + +RG+ P++G + RS RSH T R RS ++S + R
Sbjct: 681 SRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSH-SRTPQRRGRSGSSSERKNKSRTSQR 739
Query: 727 NIVRQKATEVEECQQSENAPAAGSGHLTVGQQQQVLRSSSTSDIPEP----------LCS 776
+ E+++ + S + S + + + LR S + P P S
Sbjct: 740 RSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRS 799
Query: 777 DSSQGQKAENT---QNSSSSEPQPIQENKGHVKREHEGITILVRRSSSPAELDLKDDLQQ 833
SSQ + T ++ SSS P P Q++K ++ H SSS +K
Sbjct: 800 GSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSH---------SSSSPHPKVKSGTPP 850
Query: 834 TQGKCRERQKSESTNSDTTLGCTNEAELSMGPWQTCEEDPELNTPT 879
QG Q +E + + C + DPEL + T
Sbjct: 851 RQGSITSPQANEQSVTPQRRSCFESS-----------PDPELKSRT 885
>gi|28557802 sterile alpha motif domain containing 14 [Homo sapiens]
Length = 445
Score = 32.7 bits (73), Expect = 3.4
Identities = 37/180 (20%), Positives = 69/180 (38%), Gaps = 26/180 (14%)
Query: 700 RSHPDVTEPMRFRSATTSGAPGV---EKARNIVRQKATEVEECQQSENAPAAGSGHLTVG 756
R+ P + R S +P + +K R + ++ GS L++G
Sbjct: 160 RAEPHSEDDSRDASPPEPASPTIGLDKKTRRKFLDLGVTLRRASTGKSRKEKGSNRLSMG 219
Query: 757 QQQQVL---RSSSTSDIPEPLCSDSSQGQKAENTQNSSSSEPQPIQENKGHVKREHEGIT 813
++ V RS + +P +DS +G + + S + P+ HEG +
Sbjct: 220 SRESVEGSGRSGGSPFLPFSWFTDSGKGSASSGSTTSPTCSPK------------HEGFS 267
Query: 814 ILVRRSSSPAELDLKDDLQQTQGKCRERQKS------ESTNSDTTLGCTNEAELSMGPWQ 867
++S+S A+L + C + EST SD + ++ ++ GPWQ
Sbjct: 268 --PKKSASQAQLLAHAQEALSNSWCLVQDFGSTQIGMESTLSDDSTPPSSSPKIPSGPWQ 325
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 72,321,813
Number of Sequences: 37866
Number of extensions: 3347192
Number of successful extensions: 9565
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 17
Number of HSP's successfully gapped in prelim test: 34
Number of HSP's that attempted gapping in prelim test: 9403
Number of HSP's gapped (non-prelim): 146
length of query: 1873
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1756
effective length of database: 13,817,196
effective search space: 24262996176
effective search space used: 24262996176
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.