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Search of human proteins with 239750800
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo
sapiens]
(596 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo ... 1196 0.0
gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo s... 745 0.0
gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo s... 744 0.0
gi|126032348 hect domain and RLD 2 [Homo sapiens] 636 0.0
gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens] 137 4e-32
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 102 1e-21
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens] 102 1e-21
gi|4557445 regulator of chromosome condensation and BTB domain c... 102 1e-21
gi|110825982 hect domain and RLD 5 [Homo sapiens] 94 3e-19
gi|30039692 NIMA-related kinase 8 [Homo sapiens] 90 5e-18
gi|61563742 hect domain and RLD 6 [Homo sapiens] 88 2e-17
gi|57242759 regulator of chromosome condensation (RCC1) and BTB ... 86 1e-16
gi|7657152 hect domain and RLD 3 [Homo sapiens] 85 2e-16
gi|209969703 regulator of chromosome condensation 2 [Homo sapiens] 77 6e-14
gi|29789090 regulator of chromosome condensation 2 [Homo sapiens] 77 6e-14
gi|6912330 deafness locus associated putative guanine nucleotide... 74 3e-13
gi|57863304 inhibitor of Bruton's tyrosine kinase [Homo sapiens] 71 3e-12
gi|40316935 alsin isoform 1 [Homo sapiens] 68 2e-11
gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo... 67 4e-11
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 67 4e-11
gi|63054860 RCC1 domain containing 1 [Homo sapiens] 65 2e-10
gi|63054858 RCC1 domain containing 1 [Homo sapiens] 65 2e-10
gi|114796646 regulator of chromosome condensation 1 isoform b [H... 60 6e-09
gi|114796644 regulator of chromosome condensation 1 isoform a [H... 60 6e-09
gi|4502801 regulator of chromosome condensation 1 isoform c [Hom... 60 6e-09
gi|114796642 regulator of chromosome condensation 1 [Homo sapiens] 60 6e-09
gi|114796640 regulator of chromosome condensation 1 [Homo sapiens] 60 6e-09
gi|114796648 regulator of chromosome condensation 1 [Homo sapiens] 60 6e-09
gi|222136641 NIMA-related kinase 9 [Homo sapiens] 57 4e-08
gi|209364523 alsin isoform 2 [Homo sapiens] 56 1e-07
>gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo
sapiens]
Length = 596
Score = 1196 bits (3095), Expect = 0.0
Identities = 596/596 (100%), Positives = 596/596 (100%)
Query: 1 MDSDYTVKAYIEIILSKLSGYESLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQ 60
MDSDYTVKAYIEIILSKLSGYESLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQ
Sbjct: 1 MDSDYTVKAYIEIILSKLSGYESLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQ 60
Query: 61 IECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHC 120
IECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHC
Sbjct: 61 IECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHC 120
Query: 121 LAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTTVDV 180
LAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTTVDV
Sbjct: 121 LAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTTVDV 180
Query: 181 ATPSVHEPVLFQTARDPLGASYLGVPSDVNSSAASNKISGASNSKPYHPSLAKILLSLDG 240
ATPSVHEPVLFQTARDPLGASYLGVPSDVNSSAASNKISGASNSKPYHPSLAKILLSLDG
Sbjct: 181 ATPSVHEPVLFQTARDPLGASYLGVPSDVNSSAASNKISGASNSKPYHPSLAKILLSLDG 240
Query: 241 NLAKQQALSHILTALQIMYARDAVVGALMPAAMIAPVEFPSAAASDAFAMASPMNGEECM 300
NLAKQQALSHILTALQIMYARDAVVGALMPAAMIAPVEFPSAAASDAFAMASPMNGEECM
Sbjct: 241 NLAKQQALSHILTALQIMYARDAVVGALMPAAMIAPVEFPSAAASDAFAMASPMNGEECM 300
Query: 301 LAVDIEDRLSPNPWQEKREIVSSEDVVTPSAVTPSALSASAGPFITVTDDPGAASIFAET 360
LAVDIEDRLSPNPWQEKREIVSSEDVVTPSAVTPSALSASAGPFITVTDDPGAASIFAET
Sbjct: 301 LAVDIEDRLSPNPWQEKREIVSSEDVVTPSAVTPSALSASAGPFITVTDDPGAASIFAET 360
Query: 361 MTKTEEVADMLLELCVTELEDVATRLAERPPLFSACDSGSLFSVAPKVIPVFFGSIQAVY 420
MTKTEEVADMLLELCVTELEDVATRLAERPPLFSACDSGSLFSVAPKVIPVFFGSIQAVY
Sbjct: 361 MTKTEEVADMLLELCVTELEDVATRLAERPPLFSACDSGSLFSVAPKVIPVFFGSIQAVY 420
Query: 421 RRCPQFFRFSSSLDTPEVEVLLTSNAAHSPGDPQLPSDLAAHWAFPQPLVSVMFAVKLDQ 480
RRCPQFFRFSSSLDTPEVEVLLTSNAAHSPGDPQLPSDLAAHWAFPQPLVSVMFAVKLDQ
Sbjct: 421 RRCPQFFRFSSSLDTPEVEVLLTSNAAHSPGDPQLPSDLAAHWAFPQPLVSVMFAVKLDQ 480
Query: 481 GSGVAVQKDSGWNLTGSAPQSGTTTLSQSWMASTGSSPCGQMFASVVFSSVVGCDRISAS 540
GSGVAVQKDSGWNLTGSAPQSGTTTLSQSWMASTGSSPCGQMFASVVFSSVVGCDRISAS
Sbjct: 481 GSGVAVQKDSGWNLTGSAPQSGTTTLSQSWMASTGSSPCGQMFASVVFSSVVGCDRISAS 540
Query: 541 SRKCLWAIPGLLPDGHSEAEIWRGSLGLLRCCSTPPLLSTAARPSAPSRAASSGLC 596
SRKCLWAIPGLLPDGHSEAEIWRGSLGLLRCCSTPPLLSTAARPSAPSRAASSGLC
Sbjct: 541 SRKCLWAIPGLLPDGHSEAEIWRGSLGLLRCCSTPPLLSTAARPSAPSRAASSGLC 596
>gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo
sapiens]
Length = 1052
Score = 745 bits (1924), Expect = 0.0
Identities = 371/376 (98%), Positives = 372/376 (98%)
Query: 24 LVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKG 83
LVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKG
Sbjct: 676 LVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKG 735
Query: 84 DYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNG 143
DYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNG
Sbjct: 736 DYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNG 795
Query: 144 TTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTTVDVATPSVHEPVLFQTARDPLGASYL 203
TTTVNRKP LVQGLEGQKIMCVACGSSHSVAWTT+DVATPSVHEPVLFQTARDPLGASYL
Sbjct: 796 TTTVNRKPMLVQGLEGQKIMCVACGSSHSVAWTTMDVATPSVHEPVLFQTARDPLGASYL 855
Query: 204 GVPSDVNSSAASNKISGASNSKPYHPSLAKILLSLDGNLAKQQALSHILTALQIMYARDA 263
GVPSDVNSSAASNKISGASNSKPYHPSLAKILLSLDGNLAKQQALSHILTALQIMYARDA
Sbjct: 856 GVPSDVNSSAASNKISGASNSKPYHPSLAKILLSLDGNLAKQQALSHILTALQIMYARDA 915
Query: 264 VVGALMPAAMIAPVEFPSAAASDAFAMASPMNGEECMLAVDIEDRLSPNPWQEKREIVSS 323
VVGALMPAAMIAPVE PSAAASDAFAMASPMNGEECMLAVDIEDRLSPNPWQEKREIVSS
Sbjct: 916 VVGALMPAAMIAPVECPSAAASDAFAMASPMNGEECMLAVDIEDRLSPNPWQEKREIVSS 975
Query: 324 EDVVTPSAVTPSALSASAGPFITVTDDPGAASIFAETMTKTEEVADMLLELCVTELEDVA 383
EDVVTPSAVTPSALSASAGPFITVTDDPGAASIFAETMTKTEEVADMLLELCVTELEDVA
Sbjct: 976 EDVVTPSAVTPSALSASAGPFITVTDDPGAASIFAETMTKTEEVADMLLELCVTELEDVA 1035
Query: 384 TRLAERPPLFSACDSG 399
TRLAERPPLFSAC G
Sbjct: 1036 TRLAERPPLFSACGGG 1051
Score = 38.1 bits (87), Expect = 0.023
Identities = 17/50 (34%), Positives = 27/50 (54%)
Query: 127 GQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWT 176
G V++WGD D G+ G G + P ++ L GQ + + CG+ +A T
Sbjct: 675 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALT 724
>gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo
sapiens]
Length = 1102
Score = 744 bits (1922), Expect = 0.0
Identities = 371/376 (98%), Positives = 372/376 (98%)
Query: 24 LVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKG 83
LVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKG
Sbjct: 726 LVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKG 785
Query: 84 DYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNG 143
DYFRLGHRSDVHVRK QVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNG
Sbjct: 786 DYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNG 845
Query: 144 TTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTTVDVATPSVHEPVLFQTARDPLGASYL 203
TTTVNRKP LVQGLEGQKIMCVACGSSHSVAWTT+DVATPSVHEPVLFQTARDPLGASYL
Sbjct: 846 TTTVNRKPMLVQGLEGQKIMCVACGSSHSVAWTTMDVATPSVHEPVLFQTARDPLGASYL 905
Query: 204 GVPSDVNSSAASNKISGASNSKPYHPSLAKILLSLDGNLAKQQALSHILTALQIMYARDA 263
GVPSDVNSSAASNKISGASNSKPYHPSLAKILLSLDGNLAKQQALSHILTALQIMYARDA
Sbjct: 906 GVPSDVNSSAASNKISGASNSKPYHPSLAKILLSLDGNLAKQQALSHILTALQIMYARDA 965
Query: 264 VVGALMPAAMIAPVEFPSAAASDAFAMASPMNGEECMLAVDIEDRLSPNPWQEKREIVSS 323
VVGALMPAAMIAPVEFPSAAASDAFAMASPMNGEECMLAVDIEDRLSPNPWQEKREIVSS
Sbjct: 966 VVGALMPAAMIAPVEFPSAAASDAFAMASPMNGEECMLAVDIEDRLSPNPWQEKREIVSS 1025
Query: 324 EDVVTPSAVTPSALSASAGPFITVTDDPGAASIFAETMTKTEEVADMLLELCVTELEDVA 383
EDVVTPSAVTPSALSASAGPFITVTDDPGAASIFAETMTKTEEVADMLLELCVTELEDVA
Sbjct: 1026 EDVVTPSAVTPSALSASAGPFITVTDDPGAASIFAETMTKTEEVADMLLELCVTELEDVA 1085
Query: 384 TRLAERPPLFSACDSG 399
TRLAERPPLFSAC G
Sbjct: 1086 TRLAERPPLFSACGGG 1101
Score = 38.1 bits (87), Expect = 0.023
Identities = 17/50 (34%), Positives = 27/50 (54%)
Query: 127 GQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWT 176
G V++WGD D G+ G G + P ++ L GQ + + CG+ +A T
Sbjct: 725 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALT 774
>gi|126032348 hect domain and RLD 2 [Homo sapiens]
Length = 4834
Score = 636 bits (1640), Expect = 0.0
Identities = 324/348 (93%), Positives = 326/348 (93%), Gaps = 3/348 (0%)
Query: 22 ESLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWG 81
E LVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQF LALTKSGVVWTWG
Sbjct: 3171 EGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWG 3230
Query: 82 KGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG 141
KGDYFRLGH SDVHVRKPQVVEGLRGKKIVHVAVGA HCLAV DSGQVYAWGDNDHGQQG
Sbjct: 3231 KGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQG 3290
Query: 142 NGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTTVDVATPSVHEPVLFQTARDPLGAS 201
NGTTTVNRKPTLVQGLEGQKI VACGSSHSVAWTTVDVATPSVHEPVLFQTARDPLGAS
Sbjct: 3291 NGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWTTVDVATPSVHEPVLFQTARDPLGAS 3350
Query: 202 YLGVPSDVNSSAASNKISGASNSKPYHPSLAKILLSLDGNLAKQQALSHILTALQIMYAR 261
YLGVPSD +SSAASNKISGASNSKP PSLAKILLSLDGNLAKQQALSHILTALQIMYAR
Sbjct: 3351 YLGVPSDADSSAASNKISGASNSKPNRPSLAKILLSLDGNLAKQQALSHILTALQIMYAR 3410
Query: 262 DAVVGALMPAAMIAPVE---FPSAAASDAFAMASPMNGEECMLAVDIEDRLSPNPWQEKR 318
DAVVGALMPAAMIAPVE F SAA SDA AMASPMNGEECMLAVDIEDRLSPNPWQEKR
Sbjct: 3411 DAVVGALMPAAMIAPVECPSFSSAAPSDASAMASPMNGEECMLAVDIEDRLSPNPWQEKR 3470
Query: 319 EIVSSEDVVTPSAVTPSALSASAGPFITVTDDPGAASIFAETMTKTEE 366
EIVSSED VTPSAVTPSA SASA PFI VTDD GAASI AETMTKT+E
Sbjct: 3471 EIVSSEDAVTPSAVTPSAPSASARPFIPVTDDLGAASIIAETMTKTKE 3518
Score = 215 bits (547), Expect = 1e-55
Identities = 91/156 (58%), Positives = 123/156 (78%)
Query: 22 ESLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWG 81
+ V+SWGDGD+GKLGRGGS+GC +P I+ L G GV ++ECG+QF +ALTKSG V+TWG
Sbjct: 4163 DDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWG 4222
Query: 82 KGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG 141
KGDY RLGH SD HVR+P+ V+GL+GKK++ +A G+ HC+ + G+VY WGDND GQ G
Sbjct: 4223 KGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLG 4282
Query: 142 NGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTT 177
+GTT ++P LV L+G+K+ VACGS+H++AW+T
Sbjct: 4283 DGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWST 4318
Score = 170 bits (431), Expect = 3e-42
Identities = 74/153 (48%), Positives = 109/153 (71%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 84
V+SWGDGD+GKLGRGGS+GC P+ IE+L V ++ CG+QF +ALTK G V++WGKGD
Sbjct: 626 VWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGD 685
Query: 85 YFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGT 144
RLGH ++ HVR P+++EGL+GKK++ VA G+ HCLA+ + +V++WG ND Q +
Sbjct: 686 NQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTL 745
Query: 145 TTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTT 177
+P + GL+ + I+ +ACG + S AW++
Sbjct: 746 RVTKPEPAALPGLDTKHIVGIACGPAQSFAWSS 778
Score = 125 bits (315), Expect = 8e-29
Identities = 62/157 (39%), Positives = 97/157 (61%), Gaps = 2/157 (1%)
Query: 22 ESLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGA--QFLLALTKSGVVWT 79
E +++WG G++G+LG G SE IP + L G V + CG+ LA+T++G VW+
Sbjct: 569 EGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWS 628
Query: 80 WGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQ 139
WG GDY +LG + P+++E L+ +V V G+Q +A+ GQVY+WG D+ +
Sbjct: 629 WGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQR 688
Query: 140 QGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWT 176
G+GT R P L++GL+G+K++ VA GS+H +A T
Sbjct: 689 LGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALT 725
Score = 121 bits (304), Expect = 2e-27
Identities = 62/154 (40%), Positives = 91/154 (59%), Gaps = 2/154 (1%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 84
VFSWG+GD GKLG C+ P+ IE L + + I CG+ ALT SG ++TWG G+
Sbjct: 3068 VFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGE 3127
Query: 85 YFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQ--HCLAVMDSGQVYAWGDNDHGQQGN 142
Y RLGH + KP++V+ L G +++ VA G++ LA+ D G V++WGD D G+ G
Sbjct: 3128 YGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGR 3187
Query: 143 GTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWT 176
G + P ++ L GQ + + CG+ S+A T
Sbjct: 3188 GGSEGCNIPQNIERLNGQGVCQIECGAQFSLALT 3221
Score = 119 bits (298), Expect = 8e-27
Identities = 62/158 (39%), Positives = 94/158 (59%), Gaps = 6/158 (3%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLN----GQGVCQIECGAQFLLALTKSGVVWTW 80
V+SWG GD G+LG G + P+ I + G+ V I CG+ + A+T G ++TW
Sbjct: 516 VYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTW 575
Query: 81 GKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGA--QHCLAVMDSGQVYAWGDNDHG 138
G+G+Y RLGH S P +V GL+G K++ VA G+ LAV ++GQV++WGD D+G
Sbjct: 576 GRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYG 635
Query: 139 QQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWT 176
+ G G + + P L++ L+ ++ V CGS S+A T
Sbjct: 636 KLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALT 673
Score = 116 bits (291), Expect = 5e-26
Identities = 60/157 (38%), Positives = 87/157 (55%), Gaps = 2/157 (1%)
Query: 22 ESLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWG 81
E V+SWG+ + GKLG G C+ P+ IE L G V + G +T +G ++TWG
Sbjct: 4057 EGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWG 4116
Query: 82 KGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGA--QHCLAVMDSGQVYAWGDNDHGQ 139
KG Y RLGH KP++VE L+G ++V +A G+ L + D V++WGD D+G+
Sbjct: 4117 KGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGK 4176
Query: 140 QGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWT 176
G G + + P + L G ++ V CGS SVA T
Sbjct: 4177 LGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALT 4213
Score = 106 bits (264), Expect = 7e-23
Identities = 57/151 (37%), Positives = 91/151 (60%), Gaps = 3/151 (1%)
Query: 22 ESLVFSWGDGDFGKLGRGGSEGC-NIPQNIERLNGQGVCQI--ECGAQFLLALTKSGVVW 78
E V++ G+ G+LG G S G IP+ I L+ V ++ G + ALT G V+
Sbjct: 3010 EGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVF 3069
Query: 79 TWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHG 138
+WG+GD +LGH S ++ KP+++E L+ K+I +A G+ H A+ SG++Y WG ++G
Sbjct: 3070 SWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYG 3129
Query: 139 QQGNGTTTVNRKPTLVQGLEGQKIMCVACGS 169
+ G+G T KP +V+ L G +++ VACGS
Sbjct: 3130 RLGHGDNTTQLKPKMVKVLLGHRVIQVACGS 3160
Score = 99.4 bits (246), Expect = 8e-21
Identities = 49/147 (33%), Positives = 85/147 (57%), Gaps = 2/147 (1%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQI--ECGAQFLLALTKSGVVWTWGK 82
+++ G G G+LG GG+E + P +E + + ++ G + LAL+ G V++WG+
Sbjct: 4006 LYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGE 4065
Query: 83 GDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGN 142
+ +LGH + +P+V+E LRG ++V VA G H V +G +Y WG +G+ G+
Sbjct: 4066 AEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGH 4125
Query: 143 GTTTVNRKPTLVQGLEGQKIMCVACGS 169
+ KP LV+ L+G +++ +ACGS
Sbjct: 4126 SDSEDQLKPKLVEALQGHRVVDIACGS 4152
Score = 89.7 bits (221), Expect = 7e-18
Identities = 46/129 (35%), Positives = 76/129 (58%), Gaps = 6/129 (4%)
Query: 47 PQNIERLNGQGVCQIECGAQ--FLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEG 104
PQ ++ L + + +I + LAL +G V++WG GD RLGH V + +P+V+
Sbjct: 484 PQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISA 543
Query: 105 LRGKK----IVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQ 160
GK+ +VH+A G+ + A+ G++Y WG ++G+ G+G++ P LV GL+G
Sbjct: 544 FSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGL 603
Query: 161 KIMCVACGS 169
K++ VACGS
Sbjct: 604 KVIDVACGS 612
Score = 85.1 bits (209), Expect = 2e-16
Identities = 53/162 (32%), Positives = 83/162 (51%), Gaps = 6/162 (3%)
Query: 19 SGYESLVFSWGDGDFGKLGRGGSEGCNI--PQNIERLNGQGVCQIECGAQFLLALTKSGV 76
+G ++ WG G+LG G EG + P E L Q+ G Q L A+T G
Sbjct: 3948 AGGSGTIYGWGHNHRGQLG--GIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGK 4005
Query: 77 VWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAV--GAQHCLAVMDSGQVYAWGD 134
++ G G RLG V P ++E ++ I VAV G +HCLA+ G+VY+WG+
Sbjct: 4006 LYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGE 4065
Query: 135 NDHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWT 176
+ G+ G+G + +P +++ L G +++ VA G +HS T
Sbjct: 4066 AEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVT 4107
Score = 84.0 bits (206), Expect = 4e-16
Identities = 58/174 (33%), Positives = 88/174 (50%), Gaps = 9/174 (5%)
Query: 13 IILSKLSGYESL------VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQ 66
+I K +G ES VF WG D +LG +P E L+ V Q+ G++
Sbjct: 2943 LIRKKAAGLESAATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSK 3002
Query: 67 FLLALTKSGVVWTWGKGDYFRLGHR-SDVHVRKPQVVEGLRGKKIVHVAV--GAQHCLAV 123
L A+T G V+ G+ RLG S V P+ + L + VAV G +H A+
Sbjct: 3003 SLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATAL 3062
Query: 124 MDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTT 177
G+V++WG+ D G+ G+ + KP L++ L+ ++I +ACGSSHS A T+
Sbjct: 3063 TVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTS 3116
Score = 40.0 bits (92), Expect = 0.006
Identities = 18/50 (36%), Positives = 29/50 (58%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKS 74
V++WGD D G+LG G + P+ + L G+ V ++ CG+ LA + S
Sbjct: 4270 VYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTS 4319
>gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]
Length = 4861
Score = 137 bits (344), Expect = 4e-32
Identities = 74/169 (43%), Positives = 101/169 (59%), Gaps = 2/169 (1%)
Query: 23 SLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGK 82
S+V+++GDGD+GKLG G S + PQ I+ L G G+ ++ CG QF +ALTK G V+T+G+
Sbjct: 4206 SMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQ 4265
Query: 83 GDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGN 142
L + +PQ + L G I VAVGA+H LA+ +G VYAWG N GQ G
Sbjct: 4266 DRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGL 4325
Query: 143 GTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTT--VDVATPSVHEPV 189
G T R+PTLV GL+G+ + ++ G HS AWT V P V P+
Sbjct: 4326 GHTNHVREPTLVTGLQGKNVRQISAGRCHSAAWTAPPVPPRAPGVSVPL 4374
Score = 122 bits (305), Expect = 1e-27
Identities = 67/153 (43%), Positives = 89/153 (58%), Gaps = 1/153 (0%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 84
VFSWGDGD+GKLG G S+ P+ IE L G+ V Q+ CG + +T G ++T+G GD
Sbjct: 4103 VFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGD 4162
Query: 85 YFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAV-MDSGQVYAWGDNDHGQQGNG 143
Y RLG + + + P+ V L G +I VA G H LAV D V+A+GD D+G+ G G
Sbjct: 4163 YGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLG 4222
Query: 144 TTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWT 176
+T P + L G I VACG+ SVA T
Sbjct: 4223 NSTAKSSPQKIDVLCGIGIKKVACGTQFSVALT 4255
Score = 118 bits (295), Expect = 2e-26
Identities = 64/155 (41%), Positives = 92/155 (59%), Gaps = 2/155 (1%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 84
V+S+G GD GKLG G + P+ IE L G + ++ G+Q LALT +G V+ WG G
Sbjct: 583 VWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGA 642
Query: 85 YFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGT 144
G S+ +P+++E L +IV V++G HCLA+ +VYAWG+N GQ G G
Sbjct: 643 CLGCGS-SEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGN 701
Query: 145 TT-VNRKPTLVQGLEGQKIMCVACGSSHSVAWTTV 178
+T KP V GL+G I ++ G+SHS+AWT +
Sbjct: 702 STGPITKPKKVSGLDGIAIQQISAGTSHSLAWTAL 736
Score = 113 bits (283), Expect = 4e-25
Identities = 57/153 (37%), Positives = 96/153 (62%), Gaps = 3/153 (1%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQI--ECGAQ-FLLALTKSGVVWTWG 81
V + G+G +G+LG+G S+ ++ I L G V Q+ CG+ +ALT+SG V++WG
Sbjct: 4048 VLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWG 4107
Query: 82 KGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG 141
GDY +LGH + R+P+ +E L+G+++V ++ G +H V G+++ +G+ D+G+ G
Sbjct: 4108 DGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLG 4167
Query: 142 NGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVA 174
G T+ + P V LEG +I VACG +H++A
Sbjct: 4168 LGNTSNKKLPERVTALEGYQIGQVACGLNHTLA 4200
Score = 110 bits (275), Expect = 4e-24
Identities = 60/151 (39%), Positives = 90/151 (59%), Gaps = 4/151 (2%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSG-VVWTWGKG 83
+++WG+GDFG+LG G S NIP ++ ++ G ++ CG+ +AL+K G VW++G G
Sbjct: 532 LYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVG--EVSCGSSHTIALSKDGRTVWSFGGG 589
Query: 84 DYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNG 143
D +LGH V KP+V+E L+G I V G+Q LA+ +GQVYAWG G+
Sbjct: 590 DNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSS 649
Query: 144 TTTVNRKPTLVQGLEGQKIMCVACGSSHSVA 174
T R P L++ L +I+ V+ G SH +A
Sbjct: 650 EATALR-PKLIEELAATRIVDVSIGDSHCLA 679
Score = 103 bits (256), Expect = 6e-22
Identities = 58/158 (36%), Positives = 91/158 (57%), Gaps = 4/158 (2%)
Query: 22 ESLVFSWGDGDFGKLGRGGSEGCNIPQNIE-RLNGQGVCQIECGAQFLLALTKSGVVWTW 80
E VFSWGDGD+GKLG G S P+ I+ L G+ V + G + A+T+ G ++TW
Sbjct: 476 EGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTW 535
Query: 81 GKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQ-VYAWGDNDHGQ 139
G+GD+ RLGH P +V+ + + V+ G+ H +A+ G+ V+++G D+G+
Sbjct: 536 GEGDFGRLGHGDSNSRNIPTLVKDI--SNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGK 593
Query: 140 QGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTT 177
G+G T KP +++ L+G I V GS S+A T+
Sbjct: 594 LGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTS 631
Score = 93.2 bits (230), Expect = 6e-19
Identities = 50/150 (33%), Positives = 85/150 (56%), Gaps = 6/150 (4%)
Query: 29 GDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQ---FLLALTKSGVVWTWGKGDY 85
G G +G+LG G S + + + + + ++ LA T G V++WG GDY
Sbjct: 428 GKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDY 487
Query: 86 FRLGHRSDVHVRKPQVVEG-LRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGT 144
+LGH + + P++++G L+GK +V V+ G +H AV + G++Y WG+ D G+ G+G
Sbjct: 488 GKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGD 547
Query: 145 TTVNRKPTLVQGLEGQKIMCVACGSSHSVA 174
+ PTLV+ + + V+CGSSH++A
Sbjct: 548 SNSRNIPTLVKDI--SNVGEVSCGSSHTIA 575
Score = 83.2 bits (204), Expect = 6e-16
Identities = 43/156 (27%), Positives = 78/156 (50%), Gaps = 6/156 (3%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 84
V+ WG G G+L G N+ + Q+ CG + +G V G+G
Sbjct: 3999 VYLWGAGRHGQLAEAGR---NVMVPAAAPSFSQAQQVICGQNCTFVIQANGTVLACGEGS 4055
Query: 85 YFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQ---HCLAVMDSGQVYAWGDNDHGQQG 141
Y RLG + + V+ L+G + + H +A+ +SG+V++WGD D+G+ G
Sbjct: 4056 YGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLG 4115
Query: 142 NGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTT 177
+G + R+P ++ L+G++++ ++CG HS T+
Sbjct: 4116 HGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTS 4151
Score = 73.9 bits (180), Expect = 4e-13
Identities = 50/156 (32%), Positives = 75/156 (48%), Gaps = 6/156 (3%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 84
V+ WG +L G E P+ + IE G ++ G V GKG
Sbjct: 374 VYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQT--IEAGQYCTFVISTDGSVRACGKGS 431
Query: 85 YFRLG--HRSDVHVRKPQVVEGLRGKKIVHVAVGAQ-HCLAVMDSGQVYAWGDNDHGQQG 141
Y RLG ++ K E R K V + G+ H LA G+V++WGD D+G+ G
Sbjct: 432 YGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLG 491
Query: 142 NGTTTVNRKPTLVQG-LEGQKIMCVACGSSHSVAWT 176
+G ++ + P L+QG L+G+ ++CV+ G HS A T
Sbjct: 492 HGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVT 527
Score = 35.4 bits (80), Expect = 0.15
Identities = 17/53 (32%), Positives = 29/53 (54%), Gaps = 1/53 (1%)
Query: 21 YESLVFSWGDGDFGKLGRGGSEG-CNIPQNIERLNGQGVCQIECGAQFLLALT 72
+++ V++WG+ G+ G+G S G P+ + L+G + QI G LA T
Sbjct: 682 HDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLAWT 734
>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
Length = 1049
Score = 102 bits (254), Expect = 1e-21
Identities = 55/154 (35%), Positives = 83/154 (53%), Gaps = 2/154 (1%)
Query: 25 VFSWGDGDFGKLGRGGSEGC-NIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKG 83
V++WG G+LG GSE C +P+NI+ L+ + Q+ CG LAL+K+ V+ WG+
Sbjct: 105 VYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQN 164
Query: 84 DYFRLGHRSDVHVR-KPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGN 142
Y +LG +D + PQ+++ L G + VA G H + SG ++ WG N GQ G
Sbjct: 165 KYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGL 224
Query: 143 GTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWT 176
P L++ L QKI+ + CG H+ A T
Sbjct: 225 NDENDRYVPNLLKSLRSQKIVYICCGEDHTAALT 258
Score = 93.2 bits (230), Expect = 6e-19
Identities = 50/133 (37%), Positives = 71/133 (53%), Gaps = 1/133 (0%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 84
+F WG FG+LG +P ++ L Q + I CG ALTK G V+T+G G
Sbjct: 211 IFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGG 270
Query: 85 YFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLA-VMDSGQVYAWGDNDHGQQGNG 143
Y +LGH S H P+ V L G + +A G QH A V SG++Y++G +GQ G G
Sbjct: 271 YGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTG 330
Query: 144 TTTVNRKPTLVQG 156
+T+ + P V+G
Sbjct: 331 STSNRKSPFTVKG 343
Score = 86.7 bits (213), Expect = 6e-17
Identities = 52/167 (31%), Positives = 82/167 (49%), Gaps = 5/167 (2%)
Query: 10 YIEIILSKLSGYESLVFSWGDGDFGKLGRGGS-EGCNIPQNIERLNGQGVCQIECGAQFL 68
Y + LSK S VF WG +G+LG G + PQ ++ L G Q+ G
Sbjct: 147 YHSLALSKASE----VFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHS 202
Query: 69 LALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQ 128
LT SG ++ WG+ + +LG + P +++ LR +KIV++ G H A+ G
Sbjct: 203 FVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGG 262
Query: 129 VYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAW 175
V+ +G +GQ G+ +T+ P V L G + +ACG H+ A+
Sbjct: 263 VFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAF 309
Score = 85.9 bits (211), Expect = 1e-16
Identities = 54/150 (36%), Positives = 79/150 (52%), Gaps = 5/150 (3%)
Query: 28 WGDGDFGKLGRGGSEGCNI--PQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGDY 85
WG+ FG+LG GG + + P+ + + V + CG + + + G V+T G D
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 86 FRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG-NGT 144
+LGH +KP+ V L + IV V+ G H LA+ D GQVYAWG + GQ G G+
Sbjct: 64 GQLGHEKSR--KKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGS 121
Query: 145 TTVNRKPTLVQGLEGQKIMCVACGSSHSVA 174
R P ++ L +I+ VACG HS+A
Sbjct: 122 EECIRVPRNIKSLSDIQIVQVACGYYHSLA 151
Score = 42.7 bits (99), Expect = 0.001
Identities = 27/84 (32%), Positives = 44/84 (52%), Gaps = 1/84 (1%)
Query: 22 ESLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLA-LTKSGVVWTW 80
E VF++G G +G+LG + P+ + L G V +I CG Q A + SG ++++
Sbjct: 260 EGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSF 319
Query: 81 GKGDYFRLGHRSDVHVRKPQVVEG 104
G G +LG S + + P V+G
Sbjct: 320 GLGGNGQLGTGSTSNRKSPFTVKG 343
>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
Length = 1057
Score = 102 bits (254), Expect = 1e-21
Identities = 55/154 (35%), Positives = 83/154 (53%), Gaps = 2/154 (1%)
Query: 25 VFSWGDGDFGKLGRGGSEGC-NIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKG 83
V++WG G+LG GSE C +P+NI+ L+ + Q+ CG LAL+K+ V+ WG+
Sbjct: 105 VYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQN 164
Query: 84 DYFRLGHRSDVHVR-KPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGN 142
Y +LG +D + PQ+++ L G + VA G H + SG ++ WG N GQ G
Sbjct: 165 KYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGL 224
Query: 143 GTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWT 176
P L++ L QKI+ + CG H+ A T
Sbjct: 225 NDENDRYVPNLLKSLRSQKIVYICCGEDHTAALT 258
Score = 93.2 bits (230), Expect = 6e-19
Identities = 50/133 (37%), Positives = 71/133 (53%), Gaps = 1/133 (0%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 84
+F WG FG+LG +P ++ L Q + I CG ALTK G V+T+G G
Sbjct: 211 IFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGG 270
Query: 85 YFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLA-VMDSGQVYAWGDNDHGQQGNG 143
Y +LGH S H P+ V L G + +A G QH A V SG++Y++G +GQ G G
Sbjct: 271 YGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTG 330
Query: 144 TTTVNRKPTLVQG 156
+T+ + P V+G
Sbjct: 331 STSNRKSPFTVKG 343
Score = 86.7 bits (213), Expect = 6e-17
Identities = 52/167 (31%), Positives = 82/167 (49%), Gaps = 5/167 (2%)
Query: 10 YIEIILSKLSGYESLVFSWGDGDFGKLGRGGS-EGCNIPQNIERLNGQGVCQIECGAQFL 68
Y + LSK S VF WG +G+LG G + PQ ++ L G Q+ G
Sbjct: 147 YHSLALSKASE----VFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHS 202
Query: 69 LALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQ 128
LT SG ++ WG+ + +LG + P +++ LR +KIV++ G H A+ G
Sbjct: 203 FVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGG 262
Query: 129 VYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAW 175
V+ +G +GQ G+ +T+ P V L G + +ACG H+ A+
Sbjct: 263 VFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAF 309
Score = 85.9 bits (211), Expect = 1e-16
Identities = 54/150 (36%), Positives = 79/150 (52%), Gaps = 5/150 (3%)
Query: 28 WGDGDFGKLGRGGSEGCNI--PQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGDY 85
WG+ FG+LG GG + + P+ + + V + CG + + + G V+T G D
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 86 FRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG-NGT 144
+LGH +KP+ V L + IV V+ G H LA+ D GQVYAWG + GQ G G+
Sbjct: 64 GQLGHEKSR--KKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGS 121
Query: 145 TTVNRKPTLVQGLEGQKIMCVACGSSHSVA 174
R P ++ L +I+ VACG HS+A
Sbjct: 122 EECIRVPRNIKSLSDIQIVQVACGYYHSLA 151
Score = 42.7 bits (99), Expect = 0.001
Identities = 27/84 (32%), Positives = 44/84 (52%), Gaps = 1/84 (1%)
Query: 22 ESLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLA-LTKSGVVWTW 80
E VF++G G +G+LG + P+ + L G V +I CG Q A + SG ++++
Sbjct: 260 EGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSF 319
Query: 81 GKGDYFRLGHRSDVHVRKPQVVEG 104
G G +LG S + + P V+G
Sbjct: 320 GLGGNGQLGTGSTSNRKSPFTVKG 343
>gi|4557445 regulator of chromosome condensation and BTB domain
containing protein 2 [Homo sapiens]
Length = 551
Score = 102 bits (254), Expect = 1e-21
Identities = 57/161 (35%), Positives = 90/161 (55%), Gaps = 2/161 (1%)
Query: 18 LSGYESLVFSWGDGDFGKLGRGGSEGCNIPQNIE-RLNGQGVCQIECGAQFLLALTKSGV 76
L+ E VF+WG + +LG G + +P +I L+ + V ++ CG+ L LT G
Sbjct: 113 LATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGE 172
Query: 77 VWTWGKGDYFRLGHRSDVHVRKPQVVEG-LRGKKIVHVAVGAQHCLAVMDSGQVYAWGDN 135
V+ WG + ++G S V+ P+ V G L+ K +V +A G C+AV+D+G+VY WG N
Sbjct: 173 VFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYN 232
Query: 136 DHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWT 176
+GQ G G + P V L+G ++ VACG +H++ T
Sbjct: 233 GNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLT 273
Score = 89.4 bits (220), Expect = 9e-18
Identities = 53/154 (34%), Positives = 78/154 (50%), Gaps = 1/154 (0%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIER-LNGQGVCQIECGAQFLLALTKSGVVWTWGKG 83
VF+WG + G++G G + IP+ + L + V I CG +A+ +G V+ WG
Sbjct: 173 VFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYN 232
Query: 84 DYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNG 143
+LG + + P V L+G ++ VA G H L + D GQVYAWG N +GQ G G
Sbjct: 233 GNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTG 292
Query: 144 TTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTT 177
+ PT V + + I AC S+H+ A T
Sbjct: 293 NKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKT 326
Score = 82.8 bits (203), Expect = 8e-16
Identities = 47/147 (31%), Positives = 78/147 (53%), Gaps = 3/147 (2%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGA-QFLLALTKSGVVWTWGKG 83
+F G G LG G + P+ ++ LNG+ + + G+ ++ T G V+TWG
Sbjct: 67 IFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHN 126
Query: 84 DYFRLGHRSDVHVRKP-QVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGN 142
Y +LG+ + H P + L K+++ VA G+ H L + G+V+AWG N+ GQ G+
Sbjct: 127 AYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGS 186
Query: 143 GTTTVNRKPTLVQG-LEGQKIMCVACG 168
G+T P V G L+ + ++ +ACG
Sbjct: 187 GSTVNQPIPRRVTGCLQNKVVVTIACG 213
Score = 55.8 bits (133), Expect = 1e-07
Identities = 29/82 (35%), Positives = 47/82 (57%), Gaps = 2/82 (2%)
Query: 98 KPQVVEGLRGKKIVHVAVGA-QHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQ- 155
+P+ ++ L GKKI ++ G+ H + G+V+ WG N + Q GNGTT P +
Sbjct: 88 EPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHIST 147
Query: 156 GLEGQKIMCVACGSSHSVAWTT 177
L ++++ VACGS HS+ T+
Sbjct: 148 NLSNKQVIEVACGSYHSLVLTS 169
Score = 54.3 bits (129), Expect = 3e-07
Identities = 35/110 (31%), Positives = 47/110 (42%), Gaps = 1/110 (0%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 84
V+ WG G+LG G S P + L G V ++ CG L LT G V+ WG
Sbjct: 226 VYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANS 285
Query: 85 YFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAV-MDSGQVYAWG 133
Y +LG + + P V + + I A + H A G VY WG
Sbjct: 286 YGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWG 335
Score = 33.5 bits (75), Expect = 0.57
Identities = 22/99 (22%), Positives = 41/99 (41%), Gaps = 10/99 (10%)
Query: 81 GKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQ 140
GK F L ++ + + V G G ++++ V + +++ G N G
Sbjct: 29 GKWPIFSLCSEEELQLIRQACVFGSAGNEVLYTTV----------NDEIFVLGTNCCGCL 78
Query: 141 GNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTTVD 179
G G +P + L G+KI C++ GS + T +
Sbjct: 79 GLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTE 117
Score = 29.6 bits (65), Expect = 8.2
Identities = 17/65 (26%), Positives = 28/65 (43%), Gaps = 7/65 (10%)
Query: 22 ESLVFSWGDGDFGKLGRGGSEGCNIPQNI----ERLNGQGVCQIECGAQFLLALTKSGVV 77
E V++WG +G+LG G + P + +R+ C A T+ G V
Sbjct: 275 EGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACH---STHTSAAKTQGGHV 331
Query: 78 WTWGK 82
+ WG+
Sbjct: 332 YMWGQ 336
>gi|110825982 hect domain and RLD 5 [Homo sapiens]
Length = 1024
Score = 94.4 bits (233), Expect = 3e-19
Identities = 50/154 (32%), Positives = 80/154 (51%), Gaps = 1/154 (0%)
Query: 25 VFSWGDGDFGKLGRGGS-EGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKG 83
+F+WG G+LG G PQ +E L G + QI G +AL+ SG +++WGK
Sbjct: 159 LFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGKN 218
Query: 84 DYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNG 143
+ +LG P ++EGL +K+ VA G H + G ++ +G HGQ G+
Sbjct: 219 ECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHN 278
Query: 144 TTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTT 177
+T +P LV L G ++ +ACG H++A+ +
Sbjct: 279 STQNELRPCLVAELVGYRVTQIACGRWHTLAYVS 312
Score = 86.7 bits (213), Expect = 6e-17
Identities = 48/132 (36%), Positives = 74/132 (56%), Gaps = 1/132 (0%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 84
++SWG + G+LG G +E + P IE L+ Q V + CG LT+ G+++T+G G
Sbjct: 212 IYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGK 271
Query: 85 YFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLA-VMDSGQVYAWGDNDHGQQGNG 143
+ +LGH S + +P +V L G ++ +A G H LA V D G+V+++G GQ GNG
Sbjct: 272 HGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNG 331
Query: 144 TTTVNRKPTLVQ 155
T P V+
Sbjct: 332 GTRDQLMPLPVK 343
Score = 62.4 bits (150), Expect = 1e-09
Identities = 43/140 (30%), Positives = 68/140 (48%), Gaps = 20/140 (14%)
Query: 40 GSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKP 99
GS G P+ I+ + ++ GA+ +L L+ G F + S H+R
Sbjct: 81 GSGGARTPKCIKLGKNMKIHSVDQGAEHMLILSSDGKP--------FEYDNYSMKHLRFE 132
Query: 100 QVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNG-----TTTVNRKPTLV 154
+ L+ KKI+ + G H LA+ G+++AWG N HGQ G G TTT P +V
Sbjct: 133 SI---LQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTT----PQIV 185
Query: 155 QGLEGQKIMCVACGSSHSVA 174
+ L G + ++ G +HS+A
Sbjct: 186 EHLAGVPLAQISAGEAHSMA 205
Score = 37.7 bits (86), Expect = 0.030
Identities = 25/76 (32%), Positives = 40/76 (52%), Gaps = 1/76 (1%)
Query: 16 SKLSGYESLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLA-LTKS 74
S L + L+F++G G G+LG ++ P + L G V QI CG LA ++
Sbjct: 255 SALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDL 314
Query: 75 GVVWTWGKGDYFRLGH 90
G V+++G G +LG+
Sbjct: 315 GKVFSFGSGKDGQLGN 330
>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
Length = 692
Score = 90.1 bits (222), Expect = 5e-18
Identities = 59/167 (35%), Positives = 80/167 (47%), Gaps = 14/167 (8%)
Query: 22 ESLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWG 81
E +F+WG GD G+LG G E + PQ + GQ ++ CG + LT G G
Sbjct: 461 ERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACG 520
Query: 82 KGDYFRLG--HRS--DVHVRKPQVVEGLR----------GKKIVHVAVGAQHCLAVMDSG 127
+ +LG H S + V QV E L + ++ + +G H AV SG
Sbjct: 521 SNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASG 580
Query: 128 QVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVA 174
Y +G N HGQ G T +R P VQGLEG K+ VACG + +VA
Sbjct: 581 DCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVACGDAFTVA 627
Score = 82.0 bits (201), Expect = 1e-15
Identities = 50/134 (37%), Positives = 68/134 (50%), Gaps = 4/134 (2%)
Query: 47 PQNIER-LNGQG---VCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVV 102
PQ I R L GQ + + CG F LT G++ T+G G LGH S + +P +V
Sbjct: 378 PQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIV 437
Query: 103 EGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKI 162
E L G ++V VA GA H LA+ +++AWG D G+ G GT + P V GQ+
Sbjct: 438 EALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEA 497
Query: 163 MCVACGSSHSVAWT 176
V CG S+ T
Sbjct: 498 QRVVCGIDSSMILT 511
Score = 62.8 bits (151), Expect = 9e-10
Identities = 44/167 (26%), Positives = 73/167 (43%), Gaps = 14/167 (8%)
Query: 24 LVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKG 83
++ ++G G G LG G + P +E L G + Q+ CGA +LAL+ ++ WG+G
Sbjct: 411 IIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAWGRG 470
Query: 84 DYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNG 143
D RLG + PQ V G++ V G + + GQ A G N + G
Sbjct: 471 DSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLD 530
Query: 144 TTTVNRKPTLVQ--------------GLEGQKIMCVACGSSHSVAWT 176
++ +P Q L+ + ++ + G++HS A T
Sbjct: 531 HLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVT 577
Score = 58.9 bits (141), Expect = 1e-08
Identities = 49/164 (29%), Positives = 74/164 (45%), Gaps = 24/164 (14%)
Query: 23 SLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTW-- 80
S V++WG G P + LN + V Q+ G +T+SG + W
Sbjct: 312 SSVYAWGGG------------LGTPLRLPMLNTE-VVQVAAGRTQKAGVTRSGRLILWEA 358
Query: 81 ---GKGDYFRLGHRSDVHVRKPQVV----EGLRGKKIVHVAVGAQHCLAVMDSGQVYAWG 133
G G L V +PQ + EG G I HVA G + D G + +G
Sbjct: 359 PPLGAGGGSLLP--GAVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFG 416
Query: 134 DNDHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTT 177
+G G+G+ T +PT+V+ L G +++ VACG+SH +A +T
Sbjct: 417 SGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALST 460
Score = 49.7 bits (117), Expect = 8e-06
Identities = 28/89 (31%), Positives = 45/89 (50%)
Query: 53 LNGQGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVH 112
L+ + + I+ G A+T SG +T+G + +LG + R P V+GL G K+
Sbjct: 558 LDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAM 617
Query: 113 VAVGAQHCLAVMDSGQVYAWGDNDHGQQG 141
VA G +A+ +VY+WG G+ G
Sbjct: 618 VACGDAFTVAIGAESEVYSWGKGARGRLG 646
Score = 47.4 bits (111), Expect = 4e-05
Identities = 21/68 (30%), Positives = 34/68 (50%)
Query: 26 FSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGDY 85
+++G G+LG G P ++ L G + + CG F +A+ V++WGKG
Sbjct: 583 YTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVACGDAFTVAIGAESEVYSWGKGAR 642
Query: 86 FRLGHRSD 93
RLG R +
Sbjct: 643 GRLGRRDE 650
Score = 30.4 bits (67), Expect = 4.8
Identities = 16/45 (35%), Positives = 23/45 (51%), Gaps = 1/45 (2%)
Query: 20 GYESLVFSWGDGDFGKLGRGGSE-GCNIPQNIERLNGQGVCQIEC 63
G ES V+SWG G G+LGR + G P ++ + V + C
Sbjct: 629 GAESEVYSWGKGARGRLGRRDEDAGLPRPVQLDETHPYTVTSVSC 673
>gi|61563742 hect domain and RLD 6 [Homo sapiens]
Length = 1022
Score = 88.2 bits (217), Expect = 2e-17
Identities = 54/152 (35%), Positives = 78/152 (51%), Gaps = 2/152 (1%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 84
V S GD G+LGR G++ +P+ I+ L V + CG + LA+ G V+ WG G
Sbjct: 44 VLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGAGS 103
Query: 85 YFRLGHRSDVHVR-KPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNG 143
+LG + P+ + L KI+ V+ G H LA+ QV++WG N HGQ G G
Sbjct: 104 EGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLG 163
Query: 144 TTTVNR-KPTLVQGLEGQKIMCVACGSSHSVA 174
++ P V+ LEG + VA G +HS A
Sbjct: 164 KEFPSQASPQRVRSLEGIPLAQVAAGGAHSFA 195
Score = 87.0 bits (214), Expect = 4e-17
Identities = 51/161 (31%), Positives = 78/161 (48%), Gaps = 5/161 (3%)
Query: 21 YESLVFSWGDGDFGKLGRGGSEGCNI-PQNIERLNGQGVCQIECGAQFLLALTKSGVVWT 79
++ VF+WG G G+LG G + + P+ I LN + Q+ CG LAL+K V++
Sbjct: 92 HKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFS 151
Query: 80 WGKGDYFRLGHRSDVHVR-KPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHG 138
WGK + +LG + + PQ V L G + VA G H A+ G + WG N G
Sbjct: 152 WGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAG 211
Query: 139 Q---QGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWT 176
Q G + KP V L+ ++ ++CG +H+ T
Sbjct: 212 QLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLT 252
Score = 83.6 bits (205), Expect = 5e-16
Identities = 54/170 (31%), Positives = 80/170 (47%), Gaps = 9/170 (5%)
Query: 10 YIEIILSKLSGYESLVFSWGDGDFGKLGRGGSEGCNI-PQNIERLNGQGVCQIECGAQFL 68
Y + LSK +S VFSWG G+LG G PQ + L G + Q+ G
Sbjct: 138 YHSLALSK----DSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHS 193
Query: 69 LALTKSGVVWTWGKGDYFRL---GHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMD 125
AL+ G + WG +L G V KP V L+ +V+++ G H +
Sbjct: 194 FALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQ 253
Query: 126 SGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAW 175
G+V+ +GDN GQ G T R P LV+ ++G + + CGS H++A+
Sbjct: 254 DGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDG-LVSQIDCGSYHTLAY 302
Score = 55.8 bits (133), Expect = 1e-07
Identities = 37/121 (30%), Positives = 56/121 (46%), Gaps = 1/121 (0%)
Query: 55 GQGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVA 114
G + Q G + L L + V + G +LG R P+ ++ L + V+
Sbjct: 22 GAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVS 81
Query: 115 VGAQHCLAVMDSGQVYAWGDNDHGQQGNGT-TTVNRKPTLVQGLEGQKIMCVACGSSHSV 173
G +H LAV G+V+AWG GQ G G ++ P + L KI+ V+CG HS+
Sbjct: 82 CGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSL 141
Query: 174 A 174
A
Sbjct: 142 A 142
Score = 45.1 bits (105), Expect = 2e-04
Identities = 23/71 (32%), Positives = 36/71 (50%)
Query: 104 GLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKIM 163
G G +++ A G +H L ++ + +V + GDN GQ G P +Q LE +
Sbjct: 19 GSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVD 78
Query: 164 CVACGSSHSVA 174
V+CG HS+A
Sbjct: 79 LVSCGKEHSLA 89
>gi|57242759 regulator of chromosome condensation (RCC1) and BTB
(POZ) domain containing protein 1 [Homo sapiens]
Length = 531
Score = 85.5 bits (210), Expect = 1e-16
Identities = 50/161 (31%), Positives = 82/161 (50%), Gaps = 2/161 (1%)
Query: 18 LSGYESLVFSWGDGDFGKLGRG-GSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGV 76
LS + +V++WG + +LG G ++G Q L + V ++ CG+ +AL G
Sbjct: 89 LSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGE 148
Query: 77 VWTWGKGDYFRLGHRSDVHVRKP-QVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDN 135
V+ WG + ++G S + P +V L K++V +A G +AV+D+G+VY WG N
Sbjct: 149 VFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYN 208
Query: 136 DHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWT 176
+GQ G G P V L + + CG +H++A T
Sbjct: 209 GNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALT 249
Score = 82.8 bits (203), Expect = 8e-16
Identities = 50/153 (32%), Positives = 85/153 (55%), Gaps = 3/153 (1%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGA-QFLLALTKSGVVWTWGKG 83
VF +G LG G ++ +P+ +E L G+ + + G+ +L T+ GVV+ WG
Sbjct: 43 VFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHN 102
Query: 84 DYFRLGH-RSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGN 142
Y +LG+ ++ + QV L K++V VA G+ H +A+ G+V+AWG N+ GQ G+
Sbjct: 103 GYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGS 162
Query: 143 GTTTVNRKPTLVQG-LEGQKIMCVACGSSHSVA 174
G+T P V L ++++ +ACG + S+A
Sbjct: 163 GSTANQPTPRKVTNCLHIKRVVGIACGQTSSMA 195
Score = 73.6 bits (179), Expect = 5e-13
Identities = 45/154 (29%), Positives = 73/154 (47%), Gaps = 1/154 (0%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIER-LNGQGVCQIECGAQFLLALTKSGVVWTWGKG 83
VF+WG + G++G G + P+ + L+ + V I CG +A+ +G V+ WG
Sbjct: 149 VFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYN 208
Query: 84 DYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNG 143
+LG ++ + P V L + + G H LA+ D G +YAWG N +GQ G G
Sbjct: 209 GNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTG 268
Query: 144 TTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTT 177
P + + + + AC S+H+ A T
Sbjct: 269 NKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKT 302
Score = 64.3 bits (155), Expect = 3e-10
Identities = 46/130 (35%), Positives = 65/130 (50%), Gaps = 4/130 (3%)
Query: 47 PQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLR 106
PQ I + + C A L +T + V+ +G LG + P+ +EGL
Sbjct: 15 PQEIASI--RKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLC 72
Query: 107 GKKIVHVAVGA-QHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLV-QGLEGQKIMC 164
GKKI ++ G+ H L + G VYAWG N + Q GNGTT P V L ++++
Sbjct: 73 GKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVE 132
Query: 165 VACGSSHSVA 174
VACGS HS+A
Sbjct: 133 VACGSHHSMA 142
Score = 55.5 bits (132), Expect = 1e-07
Identities = 34/111 (30%), Positives = 52/111 (46%), Gaps = 3/111 (2%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 84
V+ WG G+LG G + P + L+ V QI CG LALT G+++ WG
Sbjct: 202 VYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANT 261
Query: 85 YFRLGHRSDVHVRKPQVVEGLRGKKIVHVAV--GAQHCLAVMDSGQVYAWG 133
Y +LG + ++ P + + +++V +A A A G VY WG
Sbjct: 262 YGQLGTGNKNNLLSPAHIM-VEKERVVEIAACHSAHTSAAKTQGGHVYMWG 311
Score = 34.7 bits (78), Expect = 0.26
Identities = 24/81 (29%), Positives = 36/81 (44%), Gaps = 2/81 (2%)
Query: 99 PQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLE 158
PQ + +R K A L V D+ +V+ +G N G G P ++GL
Sbjct: 15 PQEIASIR--KACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLC 72
Query: 159 GQKIMCVACGSSHSVAWTTVD 179
G+KI ++ GS V +T D
Sbjct: 73 GKKIKSLSYGSGPHVLLSTED 93
Score = 33.1 bits (74), Expect = 0.74
Identities = 20/65 (30%), Positives = 30/65 (46%), Gaps = 7/65 (10%)
Query: 22 ESLVFSWGDGDFGKLGRGGSEGCNIPQNI----ERLNGQGVCQIECGAQFLLALTKSGVV 77
E L+++WG +G+LG G P +I ER+ C A A T+ G V
Sbjct: 251 EGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACH---SAHTSAAKTQGGHV 307
Query: 78 WTWGK 82
+ WG+
Sbjct: 308 YMWGQ 312
>gi|7657152 hect domain and RLD 3 [Homo sapiens]
Length = 1050
Score = 84.7 bits (208), Expect = 2e-16
Identities = 54/152 (35%), Positives = 81/152 (53%), Gaps = 4/152 (2%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 84
V++ G G+LG EG N P+ I L Q + + CG LAL+ G +++WG G
Sbjct: 55 VYTCGLNTKGQLGHE-REG-NKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGS 112
Query: 85 YFRLG-HRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNG 143
+LG ++ V P++++ L + I+ V+ G HCLA+ GQ + WG N HGQ G G
Sbjct: 113 DGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLG 172
Query: 144 TTTVNR-KPTLVQGLEGQKIMCVACGSSHSVA 174
++ P V+ LEG + VA G +HS A
Sbjct: 173 KEFPSQASPQRVRSLEGIPLAQVAAGGAHSFA 204
Score = 83.2 bits (204), Expect = 6e-16
Identities = 51/133 (38%), Positives = 70/133 (52%), Gaps = 1/133 (0%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 84
VF WG + G+LG + P +++ L Q V I CG + LTKSG V+T+G G
Sbjct: 211 VFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGS 270
Query: 85 YFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLA-VMDSGQVYAWGDNDHGQQGNG 143
+LGH S P+ V L G ++ +A G QH LA V SG +YA+G GQ G G
Sbjct: 271 CGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTG 330
Query: 144 TTTVNRKPTLVQG 156
T + P+ V+G
Sbjct: 331 HTCNVKCPSPVKG 343
Score = 82.0 bits (201), Expect = 1e-15
Identities = 61/210 (29%), Positives = 96/210 (45%), Gaps = 13/210 (6%)
Query: 26 FSWGDGDFGKLGRGGSEGCNI-PQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 84
F+WG G+LG G PQ + L G + Q+ G AL+ SG V+ WG +
Sbjct: 159 FTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNN 218
Query: 85 YFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGT 144
+LG + P V+ LR +K+V+++ G +H + SG V+ +G GQ G+ +
Sbjct: 219 AGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDS 278
Query: 145 TTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTTVDVATPSVHEPVLFQT-ARDPLGASY- 202
P V L G ++ +ACG H++A+ PS F AR LG +
Sbjct: 279 MNDEVNPRRVLELMGSEVTQIACGRQHTLAF------VPSSGLIYAFGCGARGQLGTGHT 332
Query: 203 --LGVPSDVNS--SAASNKISGASNSKPYH 228
+ PS V +A S ++S ++ YH
Sbjct: 333 CNVKCPSPVKGYWAAHSGQLSARADRFKYH 362
Score = 77.8 bits (190), Expect = 3e-14
Identities = 45/129 (34%), Positives = 70/129 (54%), Gaps = 3/129 (2%)
Query: 47 PQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLR 106
PQ ++ + V ++ CG + L + G V+T G +LGH + + KP+ + L
Sbjct: 25 PQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGN--KPEQIGALA 82
Query: 107 GKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVN-RKPTLVQGLEGQKIMCV 165
+ I+HVA G H LA+ D GQ+++WG GQ G TT + P L+Q L Q I+ V
Sbjct: 83 DQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQV 142
Query: 166 ACGSSHSVA 174
+CG+ H +A
Sbjct: 143 SCGNWHCLA 151
Score = 52.8 bits (125), Expect = 9e-07
Identities = 29/79 (36%), Positives = 42/79 (53%), Gaps = 2/79 (2%)
Query: 96 VRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQ 155
V +PQV + + + VA G H + +++ G+VY G N GQ G+ KP +
Sbjct: 22 VAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGH--EREGNKPEQIG 79
Query: 156 GLEGQKIMCVACGSSHSVA 174
L Q I+ VACG SHS+A
Sbjct: 80 ALADQHIIHVACGESHSLA 98
>gi|209969703 regulator of chromosome condensation 2 [Homo sapiens]
Length = 522
Score = 76.6 bits (187), Expect = 6e-14
Identities = 43/112 (38%), Positives = 65/112 (58%), Gaps = 3/112 (2%)
Query: 63 CGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLA 122
C A LL +T G +W+WG+ + +LGH V P+++EGL + IV A G H LA
Sbjct: 158 CAAHSLL-ITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLA 216
Query: 123 VMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGL-EGQKIMCVACGSSHSV 173
+ ++G V+A+G+N GQ G G T + P+ Q + GQ I +ACG+ S+
Sbjct: 217 LTETGSVFAFGENKMGQLGLGNQT-DAVPSPAQIMYNGQPITKMACGAEFSM 267
Score = 63.2 bits (152), Expect = 7e-10
Identities = 37/125 (29%), Positives = 68/125 (54%), Gaps = 4/125 (3%)
Query: 22 ESLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWG 81
E ++SWG + G+LG G ++ P+ IE L+ + + CG LALT++G V+ +G
Sbjct: 168 EGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFG 227
Query: 82 --KGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQ 139
K LG+++D Q++ G+ I +A GA+ + + G +Y++G ++GQ
Sbjct: 228 ENKMGQLGLGNQTDAVPSPAQIM--YNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQ 285
Query: 140 QGNGT 144
G+ +
Sbjct: 286 LGHNS 290
Score = 58.2 bits (139), Expect = 2e-08
Identities = 42/140 (30%), Positives = 67/140 (47%), Gaps = 11/140 (7%)
Query: 105 LRGKKIVHVAVG--AQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKI 162
L G ++ V G A H L + G++++WG N+ GQ G+G T P L++GL + I
Sbjct: 145 LAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVI 204
Query: 163 MCVACGSSHSVAWTTVDVATPSVHEPVLFQTARDPLGASYLGVPSDVNSSAASNKISGAS 222
+ ACG +H++A T T SV F + +G LG +D S A +G
Sbjct: 205 VSAACGRNHTLALT----ETGSV-----FAFGENKMGQLGLGNQTDAVPSPAQIMYNGQP 255
Query: 223 NSKPYHPSLAKILLSLDGNL 242
+K + +++ GNL
Sbjct: 256 ITKMACGAEFSMIMDCKGNL 275
Score = 58.2 bits (139), Expect = 2e-08
Identities = 67/284 (23%), Positives = 123/284 (43%), Gaps = 50/284 (17%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERL-NGQGVCQIECGAQFLLALTKSGVVWTWGKG 83
VF++G+ G+LG G +P + + NGQ + ++ CGA+F + + G ++++G
Sbjct: 223 VFAFGENKMGQLGLGNQTDA-VPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCP 281
Query: 84 DYFRLGHRSD----------------VHVRKPQVVEGLRGKKIV--------HVAVGAQH 119
+Y +LGH SD V R +E + +I+ VA GA H
Sbjct: 282 EYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANH 341
Query: 120 CLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQ--GLEGQKIMCVACGSSHSVAWTT 177
L + +V++WG +G+ G+ P LV+ G+ + G + S A +
Sbjct: 342 TLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSE 401
Query: 178 VD-----VATPSVHEPVLFQTARDPL----------GASYLGVPSDVNSSAASNKIS--- 219
V AT + E ++ A L G S + V +D ++ + +
Sbjct: 402 VGGLFFWGATNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGE 461
Query: 220 -GASNSKPYHPSLAKILLSLDGNLAKQQALSHILTALQIMYARD 262
G + KP + A+ + +LDG ++Q A+ + + ++ ARD
Sbjct: 462 LGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGY---SHSLVIARD 502
>gi|29789090 regulator of chromosome condensation 2 [Homo sapiens]
Length = 522
Score = 76.6 bits (187), Expect = 6e-14
Identities = 43/112 (38%), Positives = 65/112 (58%), Gaps = 3/112 (2%)
Query: 63 CGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLA 122
C A LL +T G +W+WG+ + +LGH V P+++EGL + IV A G H LA
Sbjct: 158 CAAHSLL-ITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLA 216
Query: 123 VMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGL-EGQKIMCVACGSSHSV 173
+ ++G V+A+G+N GQ G G T + P+ Q + GQ I +ACG+ S+
Sbjct: 217 LTETGSVFAFGENKMGQLGLGNQT-DAVPSPAQIMYNGQPITKMACGAEFSM 267
Score = 63.2 bits (152), Expect = 7e-10
Identities = 37/125 (29%), Positives = 68/125 (54%), Gaps = 4/125 (3%)
Query: 22 ESLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWG 81
E ++SWG + G+LG G ++ P+ IE L+ + + CG LALT++G V+ +G
Sbjct: 168 EGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFG 227
Query: 82 --KGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQ 139
K LG+++D Q++ G+ I +A GA+ + + G +Y++G ++GQ
Sbjct: 228 ENKMGQLGLGNQTDAVPSPAQIM--YNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQ 285
Query: 140 QGNGT 144
G+ +
Sbjct: 286 LGHNS 290
Score = 58.2 bits (139), Expect = 2e-08
Identities = 42/140 (30%), Positives = 67/140 (47%), Gaps = 11/140 (7%)
Query: 105 LRGKKIVHVAVG--AQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKI 162
L G ++ V G A H L + G++++WG N+ GQ G+G T P L++GL + I
Sbjct: 145 LAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVI 204
Query: 163 MCVACGSSHSVAWTTVDVATPSVHEPVLFQTARDPLGASYLGVPSDVNSSAASNKISGAS 222
+ ACG +H++A T T SV F + +G LG +D S A +G
Sbjct: 205 VSAACGRNHTLALT----ETGSV-----FAFGENKMGQLGLGNQTDAVPSPAQIMYNGQP 255
Query: 223 NSKPYHPSLAKILLSLDGNL 242
+K + +++ GNL
Sbjct: 256 ITKMACGAEFSMIMDCKGNL 275
Score = 58.2 bits (139), Expect = 2e-08
Identities = 67/284 (23%), Positives = 123/284 (43%), Gaps = 50/284 (17%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERL-NGQGVCQIECGAQFLLALTKSGVVWTWGKG 83
VF++G+ G+LG G +P + + NGQ + ++ CGA+F + + G ++++G
Sbjct: 223 VFAFGENKMGQLGLGNQTDA-VPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCP 281
Query: 84 DYFRLGHRSD----------------VHVRKPQVVEGLRGKKIV--------HVAVGAQH 119
+Y +LGH SD V R +E + +I+ VA GA H
Sbjct: 282 EYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANH 341
Query: 120 CLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQ--GLEGQKIMCVACGSSHSVAWTT 177
L + +V++WG +G+ G+ P LV+ G+ + G + S A +
Sbjct: 342 TLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSE 401
Query: 178 VD-----VATPSVHEPVLFQTARDPL----------GASYLGVPSDVNSSAASNKIS--- 219
V AT + E ++ A L G S + V +D ++ + +
Sbjct: 402 VGGLFFWGATNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGE 461
Query: 220 -GASNSKPYHPSLAKILLSLDGNLAKQQALSHILTALQIMYARD 262
G + KP + A+ + +LDG ++Q A+ + + ++ ARD
Sbjct: 462 LGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGY---SHSLVIARD 502
>gi|6912330 deafness locus associated putative guanine nucleotide
exchange factor [Homo sapiens]
Length = 458
Score = 74.3 bits (181), Expect = 3e-13
Identities = 53/163 (32%), Positives = 76/163 (46%), Gaps = 14/163 (8%)
Query: 25 VFSWGDGDFGKLG-RGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKG 83
V S G FG+LG G C +PQ IE + VC I G + +A T SG+V+ WG G
Sbjct: 122 VLSCGSNSFGQLGVPHGPRRCVVPQAIELHKEKVVC-IAAGLRHAVAATASGIVFQWGTG 180
Query: 84 DYFRLGHRSD--------VHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDN 135
G R ++P V GL K + V G+ H ++ D+G+VY WG N
Sbjct: 181 -LASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSN 239
Query: 136 DHGQQGNGTTTVNRKPTLVQG--LEGQKIMCVACGSSHSVAWT 176
HGQ N + P ++ + +K+ + G +H VA T
Sbjct: 240 KHGQLANEAAFL-PVPQKIEAHCFQNEKVTAIWSGWTHLVAQT 281
Score = 72.8 bits (177), Expect = 8e-13
Identities = 56/199 (28%), Positives = 87/199 (43%), Gaps = 34/199 (17%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIER--LNGQGVCQIECGAQFLLALTKSGVVWTWGK 82
V+ WG G+L + +PQ IE + V I G L+A T++G ++TWG+
Sbjct: 233 VYVWGSNKHGQLANEAAF-LPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGR 291
Query: 83 GDYFRLGHRSDVHVRKPQVVEGLRGKK-----------------------IVHVAVGAQH 119
DY +LG RK + EG + +K V+ G++H
Sbjct: 292 ADYGQLG-------RKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEH 344
Query: 120 CLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTTVD 179
LA++ G Y+WG N+HG G+GT P VQ L + V CG+ HS+A +
Sbjct: 345 NLAII-GGVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGHSLALCQLP 403
Query: 180 VATPSVHEPVLFQTARDPL 198
V +P + + D +
Sbjct: 404 AHPALVQDPKVTYLSPDAI 422
Score = 67.4 bits (163), Expect = 4e-11
Identities = 51/160 (31%), Positives = 77/160 (48%), Gaps = 9/160 (5%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 84
+F G G+LG G +E + L G + Q+ CG F + LT++G V + G
Sbjct: 70 LFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNS 129
Query: 85 YFRLG-HRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDN--DHGQQG 141
+ +LG PQ +E L +K+V +A G +H +A SG V+ WG G++
Sbjct: 130 FGQLGVPHGPRRCVVPQAIE-LHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRL 188
Query: 142 NGTTTV-----NRKPTLVQGLEGQKIMCVACGSSHSVAWT 176
T+ ++P+ V GLE K MCV GS HS + T
Sbjct: 189 CPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLT 228
>gi|57863304 inhibitor of Bruton's tyrosine kinase [Homo sapiens]
Length = 1353
Score = 70.9 bits (172), Expect = 3e-12
Identities = 56/193 (29%), Positives = 88/193 (45%), Gaps = 8/193 (4%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVC--QIECGAQFLLALTKSGVVWTWGK 82
V++WGD LG G + P+ ++ + G+ Q+ + L++ G V+T G
Sbjct: 144 VYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGH 203
Query: 83 GDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG- 141
G RLGH + P++VEGL G VA H + + + G VY +G N Q G
Sbjct: 204 GPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGI 263
Query: 142 ---NGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTTVDVATPSVHEPVLFQTARDPL 198
+ V R+ + L+G+ I+ VA G H+V WT V T ++ L DP
Sbjct: 264 IPPPSSCNVPRQ-IQAKYLKGRTIIGVAAGRFHTVLWTREAVYTMGLNGGQL-GCLLDPN 321
Query: 199 GASYLGVPSDVNS 211
G + P V++
Sbjct: 322 GEKCVTAPRQVSA 334
Score = 57.8 bits (138), Expect = 3e-08
Identities = 50/163 (30%), Positives = 74/163 (45%), Gaps = 13/163 (7%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 84
V++ G G G+LG G + C +P+ +E LNG Q+ + LT+ G V+T+G
Sbjct: 198 VYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNI 257
Query: 85 YFRLG---HRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG 141
+ +LG S +V + + L+G+ I+ VA G H + + VY G N GQ G
Sbjct: 258 FHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTV-LWTREAVYTMGLNG-GQLG 315
Query: 142 -----NGTTTVNRKPTLVQGLEGQKI--MCVACGSSHSVAWTT 177
NG V P V L + I VA +V TT
Sbjct: 316 CLLDPNGEKCVT-APRQVSALHHKDIALSLVAASDGATVCVTT 357
>gi|40316935 alsin isoform 1 [Homo sapiens]
Length = 1657
Score = 68.2 bits (165), Expect = 2e-11
Identities = 38/112 (33%), Positives = 57/112 (50%), Gaps = 5/112 (4%)
Query: 77 VWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDND 136
VWTWGKG +LGH + +P V+ L GK+++H+ G H LA+ QVY+WG N
Sbjct: 528 VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNT 587
Query: 137 HGQQGNG--TTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTTVDVATPSVH 186
GQ G+ TTV P L + + +A G +S+ + P ++
Sbjct: 588 FGQLGHSDFPTTV---PRLAKISSENGVWSIAAGRDYSLFLVDTEDFQPGLY 636
Score = 55.8 bits (133), Expect = 1e-07
Identities = 41/130 (31%), Positives = 65/130 (50%), Gaps = 10/130 (7%)
Query: 53 LNGQGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVE-------GL 105
L GQ V + G+ A+T +GV + WG+ + + +V +P V L
Sbjct: 88 LVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPL 147
Query: 106 RGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVN-RKPTLVQGLEGQKIMC 164
+I+ +A G +H LA+ S +++AWG Q G TT KP V+ L G+ ++
Sbjct: 148 LAVRILQLACGEEHTLALSISREIWAWGTGC--QLGLITTAFPVTKPQKVEHLAGRVVLQ 205
Query: 165 VACGSSHSVA 174
VACG+ HS+A
Sbjct: 206 VACGAFHSLA 215
Score = 52.8 bits (125), Expect = 9e-07
Identities = 31/102 (30%), Positives = 52/102 (50%), Gaps = 1/102 (0%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 84
V++WG G G+LG G P ++ L+G+ V +E G LALT V++WG
Sbjct: 528 VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNT 587
Query: 85 YFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDS 126
+ +LGH SD P++ + + +A G + L ++D+
Sbjct: 588 FGQLGH-SDFPTTVPRLAKISSENGVWSIAAGRDYSLFLVDT 628
Score = 52.4 bits (124), Expect = 1e-06
Identities = 38/138 (27%), Positives = 64/138 (46%), Gaps = 15/138 (10%)
Query: 47 PQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRS---DVHVRKPQVVE 103
P+ + G+ V Q G + + LT+ G V+++G L RS ++ P +
Sbjct: 32 PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGT-----LPWRSGPVEICPSSPILEN 86
Query: 104 GLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQ--- 160
L G+ ++ VA G+ H AV D+G Y WG+N GQ +P V + +
Sbjct: 87 ALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASP 146
Query: 161 ----KIMCVACGSSHSVA 174
+I+ +ACG H++A
Sbjct: 147 LLAVRILQLACGEEHTLA 164
Score = 50.8 bits (120), Expect = 3e-06
Identities = 31/108 (28%), Positives = 50/108 (46%), Gaps = 8/108 (7%)
Query: 24 LVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQG-------VCQIECGAQFLLALTKSGV 76
+ + WG+ G+ + P + + + + Q+ CG + LAL+ S
Sbjct: 111 VAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISRE 170
Query: 77 VWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVM 124
+W WG G L + V KPQ VE L G+ ++ VA GA H LA++
Sbjct: 171 IWAWGTGCQLGL-ITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALV 217
Score = 37.7 bits (86), Expect = 0.030
Identities = 16/49 (32%), Positives = 28/49 (57%)
Query: 128 QVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWT 176
+V+ WG GQ G+G +P V+ L+G++++ + G HS+A T
Sbjct: 527 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALT 575
Score = 31.2 bits (69), Expect = 2.8
Identities = 23/71 (32%), Positives = 31/71 (43%), Gaps = 16/71 (22%)
Query: 12 EIILSKLSGYESL-------VFSWGDGDFGKLGRGGSEGCNIPQNIERL----NGQGVCQ 60
E+I + GY SL V+SWG FG+LG + P + RL + GV
Sbjct: 560 EVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHS-----DFPTTVPRLAKISSENGVWS 614
Query: 61 IECGAQFLLAL 71
I G + L L
Sbjct: 615 IAAGRDYSLFL 625
>gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo
sapiens]
Length = 815
Score = 67.4 bits (163), Expect = 4e-11
Identities = 45/156 (28%), Positives = 78/156 (50%), Gaps = 7/156 (4%)
Query: 25 VFSWGDGDFGKLGRGGSEGCN--IPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGK 82
++ +G+ + GKLG N PQ + + + V Q+ CG + + LT++ V +T+G
Sbjct: 211 LYVFGEPENGKLGLPNQLLGNHRTPQLVSEIP-EKVIQVACGGEHTVVLTENAV-YTFGL 268
Query: 83 GDYFRLGHRSDV-HVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG 141
G + +LG + + +P+V+E +R + I +++ G H + D G +Y +GD HG+ G
Sbjct: 269 GQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLG 328
Query: 142 NGTTTVNRK--PTLVQGLEGQKIMCVACGSSHSVAW 175
G PTL + VACG H V +
Sbjct: 329 LGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVVF 364
Score = 63.2 bits (152), Expect = 7e-10
Identities = 47/161 (29%), Positives = 80/161 (49%), Gaps = 6/161 (3%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQG-VCQIECGAQFLLALTKSGVVWTWGKG 83
V++ G + G+LG G +E N I + + Q+ G+ ALT+ G ++ WG
Sbjct: 108 VYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDN 167
Query: 84 DYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG-- 141
++G ++ +V PQ V GK + ++ G H V G++Y +G+ ++G+ G
Sbjct: 168 SEGQIGLKNVSNVCVPQQVT--IGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLP 225
Query: 142 NGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTTVDVAT 182
N +R P LV + +K++ VACG H+V T V T
Sbjct: 226 NQLLGNHRTPQLVSEIP-EKVIQVACGGEHTVVLTENAVYT 265
Score = 57.4 bits (137), Expect = 4e-08
Identities = 42/158 (26%), Positives = 70/158 (44%), Gaps = 11/158 (6%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 84
++ +G ++G+LG G + P ++ L + V CG L T+ G V+ G +
Sbjct: 56 LYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNN 115
Query: 85 YFRLG-----HRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQ 139
+LG R+ HV E KI ++ G+ A+ + G+++ WGDN GQ
Sbjct: 116 EGQLGLGDTEERNTFHVISFFTSE----HKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQ 171
Query: 140 QGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTT 177
G V+ Q G+ + ++CG HS TT
Sbjct: 172 --IGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTT 207
Score = 55.8 bits (133), Expect = 1e-07
Identities = 34/117 (29%), Positives = 57/117 (48%), Gaps = 1/117 (0%)
Query: 61 IECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHC 120
+ CG + +T + ++ +G ++ +LG S + KP V+ L+ +K+ A G H
Sbjct: 40 LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHT 99
Query: 121 LAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQ-KIMCVACGSSHSVAWT 176
L + G VYA G N+ GQ G G T ++ + KI ++ GS+ S A T
Sbjct: 100 LVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALT 156
Score = 53.1 bits (126), Expect = 7e-07
Identities = 23/66 (34%), Positives = 40/66 (60%)
Query: 111 VHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSS 170
VH++ G +H V + ++Y +G N+ GQ G G+ + KPT V+ L+ +K+ ACG +
Sbjct: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRN 97
Query: 171 HSVAWT 176
H++ T
Sbjct: 98 HTLVST 103
Score = 42.4 bits (98), Expect = 0.001
Identities = 23/69 (33%), Positives = 39/69 (56%), Gaps = 1/69 (1%)
Query: 22 ESLVFSWGDGDFGKLGRGG-SEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTW 80
E+ V+++G G FG+LG G + P+ IE + Q + I CG +T G+++T+
Sbjct: 260 ENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTF 319
Query: 81 GKGDYFRLG 89
G G + +LG
Sbjct: 320 GDGRHGKLG 328
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 67.4 bits (163), Expect = 4e-11
Identities = 45/156 (28%), Positives = 78/156 (50%), Gaps = 7/156 (4%)
Query: 25 VFSWGDGDFGKLGRGGSEGCN--IPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGK 82
++ +G+ + GKLG N PQ + + + V Q+ CG + + LT++ V +T+G
Sbjct: 211 LYVFGEPENGKLGLPNQLLGNHRTPQLVSEIP-EKVIQVACGGEHTVVLTENAV-YTFGL 268
Query: 83 GDYFRLGHRSDV-HVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG 141
G + +LG + + +P+V+E +R + I +++ G H + D G +Y +GD HG+ G
Sbjct: 269 GQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLG 328
Query: 142 NGTTTVNRK--PTLVQGLEGQKIMCVACGSSHSVAW 175
G PTL + VACG H V +
Sbjct: 329 LGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVVF 364
Score = 63.2 bits (152), Expect = 7e-10
Identities = 47/161 (29%), Positives = 80/161 (49%), Gaps = 6/161 (3%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQG-VCQIECGAQFLLALTKSGVVWTWGKG 83
V++ G + G+LG G +E N I + + Q+ G+ ALT+ G ++ WG
Sbjct: 108 VYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDN 167
Query: 84 DYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG-- 141
++G ++ +V PQ V GK + ++ G H V G++Y +G+ ++G+ G
Sbjct: 168 SEGQIGLKNVSNVCVPQQVT--IGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLP 225
Query: 142 NGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTTVDVAT 182
N +R P LV + +K++ VACG H+V T V T
Sbjct: 226 NQLLGNHRTPQLVSEIP-EKVIQVACGGEHTVVLTENAVYT 265
Score = 57.4 bits (137), Expect = 4e-08
Identities = 42/158 (26%), Positives = 70/158 (44%), Gaps = 11/158 (6%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 84
++ +G ++G+LG G + P ++ L + V CG L T+ G V+ G +
Sbjct: 56 LYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNN 115
Query: 85 YFRLG-----HRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQ 139
+LG R+ HV E KI ++ G+ A+ + G+++ WGDN GQ
Sbjct: 116 EGQLGLGDTEERNTFHVISFFTSE----HKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQ 171
Query: 140 QGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTT 177
G V+ Q G+ + ++CG HS TT
Sbjct: 172 --IGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTT 207
Score = 55.8 bits (133), Expect = 1e-07
Identities = 34/117 (29%), Positives = 57/117 (48%), Gaps = 1/117 (0%)
Query: 61 IECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHC 120
+ CG + +T + ++ +G ++ +LG S + KP V+ L+ +K+ A G H
Sbjct: 40 LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHT 99
Query: 121 LAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQ-KIMCVACGSSHSVAWT 176
L + G VYA G N+ GQ G G T ++ + KI ++ GS+ S A T
Sbjct: 100 LVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALT 156
Score = 53.1 bits (126), Expect = 7e-07
Identities = 23/66 (34%), Positives = 40/66 (60%)
Query: 111 VHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSS 170
VH++ G +H V + ++Y +G N+ GQ G G+ + KPT V+ L+ +K+ ACG +
Sbjct: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRN 97
Query: 171 HSVAWT 176
H++ T
Sbjct: 98 HTLVST 103
Score = 42.4 bits (98), Expect = 0.001
Identities = 23/69 (33%), Positives = 39/69 (56%), Gaps = 1/69 (1%)
Query: 22 ESLVFSWGDGDFGKLGRGG-SEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTW 80
E+ V+++G G FG+LG G + P+ IE + Q + I CG +T G+++T+
Sbjct: 260 ENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTF 319
Query: 81 GKGDYFRLG 89
G G + +LG
Sbjct: 320 GDGRHGKLG 328
>gi|63054860 RCC1 domain containing 1 [Homo sapiens]
Length = 376
Score = 65.1 bits (157), Expect = 2e-10
Identities = 30/80 (37%), Positives = 49/80 (61%)
Query: 60 QIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQH 119
Q+E GA+ L L +G V++WG G + +LGH + +P+++E L+G + VA G H
Sbjct: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWH 221
Query: 120 CLAVMDSGQVYAWGDNDHGQ 139
+ V ++G +Y WG N+ GQ
Sbjct: 222 SVCVSETGDIYIWGWNESGQ 241
Score = 54.7 bits (130), Expect = 2e-07
Identities = 25/59 (42%), Positives = 37/59 (62%)
Query: 115 VGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSV 173
+GA+H L + +GQV++WG HGQ G+GT +P L++ L+G + VA G HSV
Sbjct: 165 LGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSV 223
Score = 54.7 bits (130), Expect = 2e-07
Identities = 41/184 (22%), Positives = 75/184 (40%), Gaps = 40/184 (21%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 84
VFSWG G G+LG G E P+ +E L G + ++ G + ++++G ++ WG +
Sbjct: 179 VFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNE 238
Query: 85 YFRLG--------------------HRSDVHVRK------------------PQVVEGLR 106
+L + V++ P +++
Sbjct: 239 SGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPM 298
Query: 107 GKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQ--KIMC 164
G V + G++H V +G++Y WG +GQ G+ TT +P V+ + ++
Sbjct: 299 GSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKA 358
Query: 165 VACG 168
V CG
Sbjct: 359 VTCG 362
>gi|63054858 RCC1 domain containing 1 [Homo sapiens]
Length = 376
Score = 65.1 bits (157), Expect = 2e-10
Identities = 30/80 (37%), Positives = 49/80 (61%)
Query: 60 QIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQH 119
Q+E GA+ L L +G V++WG G + +LGH + +P+++E L+G + VA G H
Sbjct: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWH 221
Query: 120 CLAVMDSGQVYAWGDNDHGQ 139
+ V ++G +Y WG N+ GQ
Sbjct: 222 SVCVSETGDIYIWGWNESGQ 241
Score = 54.7 bits (130), Expect = 2e-07
Identities = 25/59 (42%), Positives = 37/59 (62%)
Query: 115 VGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSV 173
+GA+H L + +GQV++WG HGQ G+GT +P L++ L+G + VA G HSV
Sbjct: 165 LGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSV 223
Score = 54.7 bits (130), Expect = 2e-07
Identities = 41/184 (22%), Positives = 75/184 (40%), Gaps = 40/184 (21%)
Query: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 84
VFSWG G G+LG G E P+ +E L G + ++ G + ++++G ++ WG +
Sbjct: 179 VFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNE 238
Query: 85 YFRLG--------------------HRSDVHVRK------------------PQVVEGLR 106
+L + V++ P +++
Sbjct: 239 SGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPM 298
Query: 107 GKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQ--KIMC 164
G V + G++H V +G++Y WG +GQ G+ TT +P V+ + ++
Sbjct: 299 GSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKA 358
Query: 165 VACG 168
V CG
Sbjct: 359 VTCG 362
>gi|114796646 regulator of chromosome condensation 1 isoform b [Homo
sapiens]
Length = 438
Score = 60.1 bits (144), Expect = 6e-09
Identities = 43/158 (27%), Positives = 71/158 (44%), Gaps = 7/158 (4%)
Query: 21 YESLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQI--ECGAQFLLALTKSGVVW 78
+E V+ +G ++ +LG G+E C IPQN+ + G + + G +
Sbjct: 274 HEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAY 333
Query: 79 TWGKGDYFRLGHRSDVHVRK-PQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDH 137
+ G+ +Y RLG + P ++ L + VA GA AV G+V+AWG +
Sbjct: 334 SLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVTKDGRVFAWGMGTN 391
Query: 138 GQQGNGTTTVNRKPTLVQG--LEGQKIMCVACGSSHSV 173
Q G G P + G LE + ++ V+ G H+V
Sbjct: 392 YQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTV 429
Score = 57.4 bits (137), Expect = 4e-08
Identities = 40/111 (36%), Positives = 56/111 (50%), Gaps = 6/111 (5%)
Query: 22 ESLVFSWGDGDFGKLGRG-GSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTW 80
E +S G ++G+LG G G+E +IP I RL V + CGA A+TK G V+ W
Sbjct: 329 EGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVTKDGRVFAW 386
Query: 81 GKGDYFRLGHRSDVHVRKPQVVEG--LRGKKIVHVAVGAQH-CLAVMDSGQ 128
G G ++LG D P + G L + ++ V+ G QH L V D Q
Sbjct: 387 GMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 437
Score = 54.7 bits (130), Expect = 2e-07
Identities = 37/125 (29%), Positives = 61/125 (48%), Gaps = 5/125 (4%)
Query: 52 RLNGQGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIV 111
R+ G CQ+ + T+ G+V T G+GD +LG +V RK + + + +V
Sbjct: 33 RVPGARSCQVSHRSHS----TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVV 87
Query: 112 HVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSH 171
G H + + SGQVY++G ND G G T+ + + +K++ V+ G SH
Sbjct: 88 QAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSH 147
Query: 172 SVAWT 176
+ A T
Sbjct: 148 TAALT 152
Score = 54.3 bits (129), Expect = 3e-07
Identities = 47/156 (30%), Positives = 71/156 (45%), Gaps = 6/156 (3%)
Query: 24 LVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKG 83
LV + G GD G+LG G + + + + V Q E G + L+KSG V+++G
Sbjct: 53 LVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKSGQVYSFGCN 111
Query: 84 DYFRLGHRSDVHVRKPQVVEGL--RGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG 141
D LG D V ++V G +K+V V+ G H A+ D G+V+ WG
Sbjct: 112 DEGALGR--DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGV 169
Query: 142 NGTTTVNRKPTL-VQGLEGQKIMCVACGSSHSVAWT 176
G +K + VQ ++ VA G+ H V T
Sbjct: 170 IGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLT 205
Score = 50.4 bits (119), Expect = 5e-06
Identities = 52/190 (27%), Positives = 80/190 (42%), Gaps = 29/190 (15%)
Query: 14 ILSKLSGYESLVFSWGDGDFGKLG----------------RGGSEGCN---IPQNI--ER 52
++ SG + LV DGD LG RGG +G +P+ + +
Sbjct: 191 VVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKS 250
Query: 53 LNGQGVCQIE---CGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKK 109
+G + + CGA F A++ G V+ +G +Y +LG PQ + +
Sbjct: 251 RGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNST 310
Query: 110 IVHVAV-GAQHCLAVMDS-GQVYAWGDNDHGQQGNGTTTVNRK-PTLVQGLEGQKIMCVA 166
V G QH MDS G+ Y+ G ++G+ G G + PTL+ L + VA
Sbjct: 311 KSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVA 368
Query: 167 CGSSHSVAWT 176
CG+S A T
Sbjct: 369 CGASVGYAVT 378
>gi|114796644 regulator of chromosome condensation 1 isoform a [Homo
sapiens]
Length = 452
Score = 60.1 bits (144), Expect = 6e-09
Identities = 43/158 (27%), Positives = 71/158 (44%), Gaps = 7/158 (4%)
Query: 21 YESLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQI--ECGAQFLLALTKSGVVW 78
+E V+ +G ++ +LG G+E C IPQN+ + G + + G +
Sbjct: 288 HEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAY 347
Query: 79 TWGKGDYFRLGHRSDVHVRK-PQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDH 137
+ G+ +Y RLG + P ++ L + VA GA AV G+V+AWG +
Sbjct: 348 SLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVTKDGRVFAWGMGTN 405
Query: 138 GQQGNGTTTVNRKPTLVQG--LEGQKIMCVACGSSHSV 173
Q G G P + G LE + ++ V+ G H+V
Sbjct: 406 YQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTV 443
Score = 57.4 bits (137), Expect = 4e-08
Identities = 40/111 (36%), Positives = 56/111 (50%), Gaps = 6/111 (5%)
Query: 22 ESLVFSWGDGDFGKLGRG-GSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTW 80
E +S G ++G+LG G G+E +IP I RL V + CGA A+TK G V+ W
Sbjct: 343 EGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVTKDGRVFAW 400
Query: 81 GKGDYFRLGHRSDVHVRKPQVVEG--LRGKKIVHVAVGAQH-CLAVMDSGQ 128
G G ++LG D P + G L + ++ V+ G QH L V D Q
Sbjct: 401 GMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 451
Score = 54.3 bits (129), Expect = 3e-07
Identities = 33/105 (31%), Positives = 54/105 (51%), Gaps = 1/105 (0%)
Query: 72 TKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYA 131
T+ G+V T G+GD +LG +V RK + + + +V G H + + SGQVY+
Sbjct: 63 TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKSGQVYS 121
Query: 132 WGDNDHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWT 176
+G ND G G T+ + + +K++ V+ G SH+ A T
Sbjct: 122 FGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALT 166
Score = 54.3 bits (129), Expect = 3e-07
Identities = 47/156 (30%), Positives = 71/156 (45%), Gaps = 6/156 (3%)
Query: 24 LVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKG 83
LV + G GD G+LG G + + + + V Q E G + L+KSG V+++G
Sbjct: 67 LVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKSGQVYSFGCN 125
Query: 84 DYFRLGHRSDVHVRKPQVVEGL--RGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG 141
D LG D V ++V G +K+V V+ G H A+ D G+V+ WG
Sbjct: 126 DEGALGR--DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGV 183
Query: 142 NGTTTVNRKPTL-VQGLEGQKIMCVACGSSHSVAWT 176
G +K + VQ ++ VA G+ H V T
Sbjct: 184 IGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLT 219
Score = 50.4 bits (119), Expect = 5e-06
Identities = 52/190 (27%), Positives = 80/190 (42%), Gaps = 29/190 (15%)
Query: 14 ILSKLSGYESLVFSWGDGDFGKLG----------------RGGSEGCN---IPQNI--ER 52
++ SG + LV DGD LG RGG +G +P+ + +
Sbjct: 205 VVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKS 264
Query: 53 LNGQGVCQIE---CGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKK 109
+G + + CGA F A++ G V+ +G +Y +LG PQ + +
Sbjct: 265 RGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNST 324
Query: 110 IVHVAV-GAQHCLAVMDS-GQVYAWGDNDHGQQGNGTTTVNRK-PTLVQGLEGQKIMCVA 166
V G QH MDS G+ Y+ G ++G+ G G + PTL+ L + VA
Sbjct: 325 KSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVA 382
Query: 167 CGSSHSVAWT 176
CG+S A T
Sbjct: 383 CGASVGYAVT 392
>gi|4502801 regulator of chromosome condensation 1 isoform c [Homo
sapiens]
Length = 421
Score = 60.1 bits (144), Expect = 6e-09
Identities = 43/158 (27%), Positives = 71/158 (44%), Gaps = 7/158 (4%)
Query: 21 YESLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQI--ECGAQFLLALTKSGVVW 78
+E V+ +G ++ +LG G+E C IPQN+ + G + + G +
Sbjct: 257 HEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAY 316
Query: 79 TWGKGDYFRLGHRSDVHVRK-PQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDH 137
+ G+ +Y RLG + P ++ L + VA GA AV G+V+AWG +
Sbjct: 317 SLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVTKDGRVFAWGMGTN 374
Query: 138 GQQGNGTTTVNRKPTLVQG--LEGQKIMCVACGSSHSV 173
Q G G P + G LE + ++ V+ G H+V
Sbjct: 375 YQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTV 412
Score = 57.4 bits (137), Expect = 4e-08
Identities = 40/111 (36%), Positives = 56/111 (50%), Gaps = 6/111 (5%)
Query: 22 ESLVFSWGDGDFGKLGRG-GSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTW 80
E +S G ++G+LG G G+E +IP I RL V + CGA A+TK G V+ W
Sbjct: 312 EGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVTKDGRVFAW 369
Query: 81 GKGDYFRLGHRSDVHVRKPQVVEG--LRGKKIVHVAVGAQH-CLAVMDSGQ 128
G G ++LG D P + G L + ++ V+ G QH L V D Q
Sbjct: 370 GMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 420
Score = 54.3 bits (129), Expect = 3e-07
Identities = 33/105 (31%), Positives = 54/105 (51%), Gaps = 1/105 (0%)
Query: 72 TKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYA 131
T+ G+V T G+GD +LG +V RK + + + +V G H + + SGQVY+
Sbjct: 32 TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKSGQVYS 90
Query: 132 WGDNDHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWT 176
+G ND G G T+ + + +K++ V+ G SH+ A T
Sbjct: 91 FGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALT 135
Score = 54.3 bits (129), Expect = 3e-07
Identities = 47/156 (30%), Positives = 71/156 (45%), Gaps = 6/156 (3%)
Query: 24 LVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKG 83
LV + G GD G+LG G + + + + V Q E G + L+KSG V+++G
Sbjct: 36 LVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKSGQVYSFGCN 94
Query: 84 DYFRLGHRSDVHVRKPQVVEGL--RGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG 141
D LG D V ++V G +K+V V+ G H A+ D G+V+ WG
Sbjct: 95 DEGALGR--DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGV 152
Query: 142 NGTTTVNRKPTL-VQGLEGQKIMCVACGSSHSVAWT 176
G +K + VQ ++ VA G+ H V T
Sbjct: 153 IGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLT 188
Score = 50.4 bits (119), Expect = 5e-06
Identities = 52/190 (27%), Positives = 80/190 (42%), Gaps = 29/190 (15%)
Query: 14 ILSKLSGYESLVFSWGDGDFGKLG----------------RGGSEGCN---IPQNI--ER 52
++ SG + LV DGD LG RGG +G +P+ + +
Sbjct: 174 VVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKS 233
Query: 53 LNGQGVCQIE---CGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKK 109
+G + + CGA F A++ G V+ +G +Y +LG PQ + +
Sbjct: 234 RGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNST 293
Query: 110 IVHVAV-GAQHCLAVMDS-GQVYAWGDNDHGQQGNGTTTVNRK-PTLVQGLEGQKIMCVA 166
V G QH MDS G+ Y+ G ++G+ G G + PTL+ L + VA
Sbjct: 294 KSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVA 351
Query: 167 CGSSHSVAWT 176
CG+S A T
Sbjct: 352 CGASVGYAVT 361
>gi|114796642 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 60.1 bits (144), Expect = 6e-09
Identities = 43/158 (27%), Positives = 71/158 (44%), Gaps = 7/158 (4%)
Query: 21 YESLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQI--ECGAQFLLALTKSGVVW 78
+E V+ +G ++ +LG G+E C IPQN+ + G + + G +
Sbjct: 257 HEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAY 316
Query: 79 TWGKGDYFRLGHRSDVHVRK-PQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDH 137
+ G+ +Y RLG + P ++ L + VA GA AV G+V+AWG +
Sbjct: 317 SLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVTKDGRVFAWGMGTN 374
Query: 138 GQQGNGTTTVNRKPTLVQG--LEGQKIMCVACGSSHSV 173
Q G G P + G LE + ++ V+ G H+V
Sbjct: 375 YQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTV 412
Score = 57.4 bits (137), Expect = 4e-08
Identities = 40/111 (36%), Positives = 56/111 (50%), Gaps = 6/111 (5%)
Query: 22 ESLVFSWGDGDFGKLGRG-GSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTW 80
E +S G ++G+LG G G+E +IP I RL V + CGA A+TK G V+ W
Sbjct: 312 EGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVTKDGRVFAW 369
Query: 81 GKGDYFRLGHRSDVHVRKPQVVEG--LRGKKIVHVAVGAQH-CLAVMDSGQ 128
G G ++LG D P + G L + ++ V+ G QH L V D Q
Sbjct: 370 GMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 420
Score = 54.3 bits (129), Expect = 3e-07
Identities = 33/105 (31%), Positives = 54/105 (51%), Gaps = 1/105 (0%)
Query: 72 TKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYA 131
T+ G+V T G+GD +LG +V RK + + + +V G H + + SGQVY+
Sbjct: 32 TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKSGQVYS 90
Query: 132 WGDNDHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWT 176
+G ND G G T+ + + +K++ V+ G SH+ A T
Sbjct: 91 FGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALT 135
Score = 54.3 bits (129), Expect = 3e-07
Identities = 47/156 (30%), Positives = 71/156 (45%), Gaps = 6/156 (3%)
Query: 24 LVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKG 83
LV + G GD G+LG G + + + + V Q E G + L+KSG V+++G
Sbjct: 36 LVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKSGQVYSFGCN 94
Query: 84 DYFRLGHRSDVHVRKPQVVEGL--RGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG 141
D LG D V ++V G +K+V V+ G H A+ D G+V+ WG
Sbjct: 95 DEGALGR--DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGV 152
Query: 142 NGTTTVNRKPTL-VQGLEGQKIMCVACGSSHSVAWT 176
G +K + VQ ++ VA G+ H V T
Sbjct: 153 IGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLT 188
Score = 50.4 bits (119), Expect = 5e-06
Identities = 52/190 (27%), Positives = 80/190 (42%), Gaps = 29/190 (15%)
Query: 14 ILSKLSGYESLVFSWGDGDFGKLG----------------RGGSEGCN---IPQNI--ER 52
++ SG + LV DGD LG RGG +G +P+ + +
Sbjct: 174 VVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKS 233
Query: 53 LNGQGVCQIE---CGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKK 109
+G + + CGA F A++ G V+ +G +Y +LG PQ + +
Sbjct: 234 RGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNST 293
Query: 110 IVHVAV-GAQHCLAVMDS-GQVYAWGDNDHGQQGNGTTTVNRK-PTLVQGLEGQKIMCVA 166
V G QH MDS G+ Y+ G ++G+ G G + PTL+ L + VA
Sbjct: 294 KSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVA 351
Query: 167 CGSSHSVAWT 176
CG+S A T
Sbjct: 352 CGASVGYAVT 361
>gi|114796640 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 60.1 bits (144), Expect = 6e-09
Identities = 43/158 (27%), Positives = 71/158 (44%), Gaps = 7/158 (4%)
Query: 21 YESLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQI--ECGAQFLLALTKSGVVW 78
+E V+ +G ++ +LG G+E C IPQN+ + G + + G +
Sbjct: 257 HEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAY 316
Query: 79 TWGKGDYFRLGHRSDVHVRK-PQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDH 137
+ G+ +Y RLG + P ++ L + VA GA AV G+V+AWG +
Sbjct: 317 SLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVTKDGRVFAWGMGTN 374
Query: 138 GQQGNGTTTVNRKPTLVQG--LEGQKIMCVACGSSHSV 173
Q G G P + G LE + ++ V+ G H+V
Sbjct: 375 YQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTV 412
Score = 57.4 bits (137), Expect = 4e-08
Identities = 40/111 (36%), Positives = 56/111 (50%), Gaps = 6/111 (5%)
Query: 22 ESLVFSWGDGDFGKLGRG-GSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTW 80
E +S G ++G+LG G G+E +IP I RL V + CGA A+TK G V+ W
Sbjct: 312 EGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVTKDGRVFAW 369
Query: 81 GKGDYFRLGHRSDVHVRKPQVVEG--LRGKKIVHVAVGAQH-CLAVMDSGQ 128
G G ++LG D P + G L + ++ V+ G QH L V D Q
Sbjct: 370 GMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 420
Score = 54.3 bits (129), Expect = 3e-07
Identities = 33/105 (31%), Positives = 54/105 (51%), Gaps = 1/105 (0%)
Query: 72 TKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYA 131
T+ G+V T G+GD +LG +V RK + + + +V G H + + SGQVY+
Sbjct: 32 TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKSGQVYS 90
Query: 132 WGDNDHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWT 176
+G ND G G T+ + + +K++ V+ G SH+ A T
Sbjct: 91 FGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALT 135
Score = 54.3 bits (129), Expect = 3e-07
Identities = 47/156 (30%), Positives = 71/156 (45%), Gaps = 6/156 (3%)
Query: 24 LVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKG 83
LV + G GD G+LG G + + + + V Q E G + L+KSG V+++G
Sbjct: 36 LVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKSGQVYSFGCN 94
Query: 84 DYFRLGHRSDVHVRKPQVVEGL--RGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG 141
D LG D V ++V G +K+V V+ G H A+ D G+V+ WG
Sbjct: 95 DEGALGR--DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGV 152
Query: 142 NGTTTVNRKPTL-VQGLEGQKIMCVACGSSHSVAWT 176
G +K + VQ ++ VA G+ H V T
Sbjct: 153 IGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLT 188
Score = 50.4 bits (119), Expect = 5e-06
Identities = 52/190 (27%), Positives = 80/190 (42%), Gaps = 29/190 (15%)
Query: 14 ILSKLSGYESLVFSWGDGDFGKLG----------------RGGSEGCN---IPQNI--ER 52
++ SG + LV DGD LG RGG +G +P+ + +
Sbjct: 174 VVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKS 233
Query: 53 LNGQGVCQIE---CGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKK 109
+G + + CGA F A++ G V+ +G +Y +LG PQ + +
Sbjct: 234 RGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNST 293
Query: 110 IVHVAV-GAQHCLAVMDS-GQVYAWGDNDHGQQGNGTTTVNRK-PTLVQGLEGQKIMCVA 166
V G QH MDS G+ Y+ G ++G+ G G + PTL+ L + VA
Sbjct: 294 KSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVA 351
Query: 167 CGSSHSVAWT 176
CG+S A T
Sbjct: 352 CGASVGYAVT 361
>gi|114796648 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 60.1 bits (144), Expect = 6e-09
Identities = 43/158 (27%), Positives = 71/158 (44%), Gaps = 7/158 (4%)
Query: 21 YESLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQI--ECGAQFLLALTKSGVVW 78
+E V+ +G ++ +LG G+E C IPQN+ + G + + G +
Sbjct: 257 HEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAY 316
Query: 79 TWGKGDYFRLGHRSDVHVRK-PQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDH 137
+ G+ +Y RLG + P ++ L + VA GA AV G+V+AWG +
Sbjct: 317 SLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVTKDGRVFAWGMGTN 374
Query: 138 GQQGNGTTTVNRKPTLVQG--LEGQKIMCVACGSSHSV 173
Q G G P + G LE + ++ V+ G H+V
Sbjct: 375 YQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTV 412
Score = 57.4 bits (137), Expect = 4e-08
Identities = 40/111 (36%), Positives = 56/111 (50%), Gaps = 6/111 (5%)
Query: 22 ESLVFSWGDGDFGKLGRG-GSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTW 80
E +S G ++G+LG G G+E +IP I RL V + CGA A+TK G V+ W
Sbjct: 312 EGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVTKDGRVFAW 369
Query: 81 GKGDYFRLGHRSDVHVRKPQVVEG--LRGKKIVHVAVGAQH-CLAVMDSGQ 128
G G ++LG D P + G L + ++ V+ G QH L V D Q
Sbjct: 370 GMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 420
Score = 54.3 bits (129), Expect = 3e-07
Identities = 33/105 (31%), Positives = 54/105 (51%), Gaps = 1/105 (0%)
Query: 72 TKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYA 131
T+ G+V T G+GD +LG +V RK + + + +V G H + + SGQVY+
Sbjct: 32 TEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKSGQVYS 90
Query: 132 WGDNDHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWT 176
+G ND G G T+ + + +K++ V+ G SH+ A T
Sbjct: 91 FGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALT 135
Score = 54.3 bits (129), Expect = 3e-07
Identities = 47/156 (30%), Positives = 71/156 (45%), Gaps = 6/156 (3%)
Query: 24 LVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKG 83
LV + G GD G+LG G + + + + V Q E G + L+KSG V+++G
Sbjct: 36 LVLTLGQGDVGQLGLGENVMERKKPALVSIP-EDVVQAEAGGMHTVCLSKSGQVYSFGCN 94
Query: 84 DYFRLGHRSDVHVRKPQVVEGL--RGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG 141
D LG D V ++V G +K+V V+ G H A+ D G+V+ WG
Sbjct: 95 DEGALGR--DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGV 152
Query: 142 NGTTTVNRKPTL-VQGLEGQKIMCVACGSSHSVAWT 176
G +K + VQ ++ VA G+ H V T
Sbjct: 153 IGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLT 188
Score = 50.4 bits (119), Expect = 5e-06
Identities = 52/190 (27%), Positives = 80/190 (42%), Gaps = 29/190 (15%)
Query: 14 ILSKLSGYESLVFSWGDGDFGKLG----------------RGGSEGCN---IPQNI--ER 52
++ SG + LV DGD LG RGG +G +P+ + +
Sbjct: 174 VVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKS 233
Query: 53 LNGQGVCQIE---CGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKK 109
+G + + CGA F A++ G V+ +G +Y +LG PQ + +
Sbjct: 234 RGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNST 293
Query: 110 IVHVAV-GAQHCLAVMDS-GQVYAWGDNDHGQQGNGTTTVNRK-PTLVQGLEGQKIMCVA 166
V G QH MDS G+ Y+ G ++G+ G G + PTL+ L + VA
Sbjct: 294 KSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVA 351
Query: 167 CGSSHSVAWT 176
CG+S A T
Sbjct: 352 CGASVGYAVT 361
>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
Length = 979
Score = 57.4 bits (137), Expect = 4e-08
Identities = 45/168 (26%), Positives = 75/168 (44%), Gaps = 15/168 (8%)
Query: 22 ESLVFSWGDGDFGKLGRGGSEGCNI--PQNIERLNGQGVCQIECGAQFLLALTKSGVVWT 79
E ++++G +G +G G + P + V Q+ CG ++ LT++ V++
Sbjct: 444 EGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYS 503
Query: 80 WGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQ 139
WG G+Y RLG S+ PQ V+ + IV V G + SG+V A G N+ +
Sbjct: 504 WGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNK 563
Query: 140 QGNG---TTTVNRKP----------TLVQGLEGQKIMCVACGSSHSVA 174
G + +N + TL + L KI +A G +H+ A
Sbjct: 564 LGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAA 611
Score = 53.9 bits (128), Expect = 4e-07
Identities = 47/182 (25%), Positives = 77/182 (42%), Gaps = 24/182 (13%)
Query: 3 SDYTVKAYIEIILSKLSGYESLVFSWGDGDFGKLGRGGSEGCNIPQNIERL-NGQGVCQI 61
S +A I ++ S+ S V+ WG G + PQ ++ + +G Q+
Sbjct: 331 SSTVTEAPIAVVTSRTSE----VYVWGGGK------------STPQKLDVIKSGCSARQV 374
Query: 62 ECGAQFLLALTKSGVVWTW-----GKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVG 116
G +T ++TW G + +LGH R+P+ VE L+GK I V+ G
Sbjct: 375 CAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQVSCG 434
Query: 117 AQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNR--KPTLVQGLEGQKIMCVACGSSHSVA 174
+ V D GQ+YA+G + +G G +P + + V+CG +H V
Sbjct: 435 DDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVV 494
Query: 175 WT 176
T
Sbjct: 495 LT 496
Score = 35.0 bits (79), Expect = 0.20
Identities = 25/90 (27%), Positives = 41/90 (45%), Gaps = 12/90 (13%)
Query: 25 VFSWGDGDFGKLGRGGSE---GCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWG 81
+ ++G G+LG G + G N+ L G+ V ++ CG +F +A T ++ WG
Sbjct: 618 LLTFGCNKCGQLGVGNYKKRLGINLLGG--PLGGKQVIRVSCGDEFTIAATDDNHIFAWG 675
Query: 82 KGDYFRLG-------HRSDVHVRKPQVVEG 104
G RL H SD+ P+ + G
Sbjct: 676 NGGNGRLAMTPTERPHGSDICTSWPRPIFG 705
Score = 33.1 bits (74), Expect = 0.74
Identities = 11/35 (31%), Positives = 22/35 (62%)
Query: 105 LRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQ 139
L GK+++ V+ G + +A D ++AWG+ +G+
Sbjct: 647 LGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGR 681
>gi|209364523 alsin isoform 2 [Homo sapiens]
Length = 396
Score = 55.8 bits (133), Expect = 1e-07
Identities = 41/130 (31%), Positives = 65/130 (50%), Gaps = 10/130 (7%)
Query: 53 LNGQGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVE-------GL 105
L GQ V + G+ A+T +GV + WG+ + + +V +P V L
Sbjct: 88 LVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPL 147
Query: 106 RGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVN-RKPTLVQGLEGQKIMC 164
+I+ +A G +H LA+ S +++AWG Q G TT KP V+ L G+ ++
Sbjct: 148 LAVRILQLACGEEHTLALSISREIWAWGTGC--QLGLITTAFPVTKPQKVEHLAGRVVLQ 205
Query: 165 VACGSSHSVA 174
VACG+ HS+A
Sbjct: 206 VACGAFHSLA 215
Score = 52.4 bits (124), Expect = 1e-06
Identities = 38/138 (27%), Positives = 64/138 (46%), Gaps = 15/138 (10%)
Query: 47 PQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRS---DVHVRKPQVVE 103
P+ + G+ V Q G + + LT+ G V+++G L RS ++ P +
Sbjct: 32 PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGT-----LPWRSGPVEICPSSPILEN 86
Query: 104 GLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQ--- 160
L G+ ++ VA G+ H AV D+G Y WG+N GQ +P V + +
Sbjct: 87 ALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASP 146
Query: 161 ----KIMCVACGSSHSVA 174
+I+ +ACG H++A
Sbjct: 147 LLAVRILQLACGEEHTLA 164
Score = 50.8 bits (120), Expect = 3e-06
Identities = 31/108 (28%), Positives = 50/108 (46%), Gaps = 8/108 (7%)
Query: 24 LVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQG-------VCQIECGAQFLLALTKSGV 76
+ + WG+ G+ + P + + + + Q+ CG + LAL+ S
Sbjct: 111 VAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISRE 170
Query: 77 VWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVM 124
+W WG G L + V KPQ VE L G+ ++ VA GA H LA++
Sbjct: 171 IWAWGTGCQLGL-ITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALV 217
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.131 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,921,468
Number of Sequences: 37866
Number of extensions: 1139610
Number of successful extensions: 3772
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 35
Number of HSP's successfully gapped in prelim test: 23
Number of HSP's that attempted gapping in prelim test: 3332
Number of HSP's gapped (non-prelim): 247
length of query: 596
length of database: 18,247,518
effective HSP length: 108
effective length of query: 488
effective length of database: 14,157,990
effective search space: 6909099120
effective search space used: 6909099120
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.