Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 239743654
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239743654 PREDICTED: similar to block of proliferation 1
[Homo sapiens]
(668 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239743654 PREDICTED: similar to block of proliferation 1 [Hom... 1379 0.0
gi|21327667 block of proliferation 1 [Homo sapiens] 1330 0.0
gi|51242945 striatin, calmodulin binding protein [Homo sapiens] 57 4e-08
gi|56243583 WD repeat domain 18 [Homo sapiens] 57 5e-08
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 55 2e-07
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 55 2e-07
gi|142976686 nuclear autoantigen isoform 1 [Homo sapiens] 55 2e-07
gi|142976675 nuclear autoantigen isoform 2 [Homo sapiens] 55 2e-07
gi|26665869 WD repeat domain 51B [Homo sapiens] 54 4e-07
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 53 8e-07
gi|89886480 zinedin isoform 2 [Homo sapiens] 53 1e-06
gi|89886477 zinedin isoform 1 [Homo sapiens] 53 1e-06
gi|19913369 transducin beta-like 3 [Homo sapiens] 52 2e-06
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 52 2e-06
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 51 4e-06
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 50 5e-06
gi|16554629 WD repeat domain 5 [Homo sapiens] 50 9e-06
gi|16554627 WD repeat domain 5 [Homo sapiens] 50 9e-06
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 49 1e-05
gi|148536855 coatomer protein complex, subunit alpha isoform 1 [... 48 3e-05
gi|148536853 coatomer protein complex, subunit alpha isoform 2 [... 48 3e-05
gi|215272341 WD repeat domain 58 isoform 2 [Homo sapiens] 47 4e-05
gi|31543164 WD repeat domain 58 isoform 1 [Homo sapiens] 47 4e-05
gi|23199987 WD repeat domain 5B [Homo sapiens] 47 7e-05
gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens] 46 1e-04
gi|134133292 WD repeat domain 27 [Homo sapiens] 45 2e-04
gi|21536371 telomerase-associated protein 1 [Homo sapiens] 45 3e-04
gi|18874090 WD repeat domain 48 [Homo sapiens] 45 3e-04
gi|14150171 THO complex 3 [Homo sapiens] 45 3e-04
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 44 5e-04
>gi|239743654 PREDICTED: similar to block of proliferation 1 [Homo
sapiens]
Length = 668
Score = 1379 bits (3568), Expect = 0.0
Identities = 668/668 (100%), Positives = 668/668 (100%)
Query: 1 MSSEAGTPACGASAPATVRVREPSPASTPCPRTEMASARIGDEYAEDSSDEEDIRNTVGN 60
MSSEAGTPACGASAPATVRVREPSPASTPCPRTEMASARIGDEYAEDSSDEEDIRNTVGN
Sbjct: 1 MSSEAGTPACGASAPATVRVREPSPASTPCPRTEMASARIGDEYAEDSSDEEDIRNTVGN 60
Query: 61 VPLEWYDDFPHVGYDLDGRRIYKPLRTRDELDQFLDKMDDPDYWRTVQDPMTGRDLRLTD 120
VPLEWYDDFPHVGYDLDGRRIYKPLRTRDELDQFLDKMDDPDYWRTVQDPMTGRDLRLTD
Sbjct: 61 VPLEWYDDFPHVGYDLDGRRIYKPLRTRDELDQFLDKMDDPDYWRTVQDPMTGRDLRLTD 120
Query: 121 EQVALVRRLQSGQFGDVGFNPYEPAVDFFSGDVMIHPVTNRPADKRSFIPSLVEKEKVSR 180
EQVALVRRLQSGQFGDVGFNPYEPAVDFFSGDVMIHPVTNRPADKRSFIPSLVEKEKVSR
Sbjct: 121 EQVALVRRLQSGQFGDVGFNPYEPAVDFFSGDVMIHPVTNRPADKRSFIPSLVEKEKVSR 180
Query: 181 MVHAIKMGWIQPRRPRDPTPSFYDLWAQEDPNAVLGRHKMHVPAPKLALPGHAESYNPPP 240
MVHAIKMGWIQPRRPRDPTPSFYDLWAQEDPNAVLGRHKMHVPAPKLALPGHAESYNPPP
Sbjct: 181 MVHAIKMGWIQPRRPRDPTPSFYDLWAQEDPNAVLGRHKMHVPAPKLALPGHAESYNPPP 240
Query: 241 EYLLSEEERLAWEQQEPGERKLSFLPRKFPSLRAVPAYGRFIQERFERCLDLYLCPRQRK 300
EYLLSEEERLAWEQQEPGERKLSFLPRKFPSLRAVPAYGRFIQERFERCLDLYLCPRQRK
Sbjct: 241 EYLLSEEERLAWEQQEPGERKLSFLPRKFPSLRAVPAYGRFIQERFERCLDLYLCPRQRK 300
Query: 301 MRVNVDPEDLIPKLPRPRDLQPFPTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLR 360
MRVNVDPEDLIPKLPRPRDLQPFPTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLR
Sbjct: 301 MRVNVDPEDLIPKLPRPRDLQPFPTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLR 360
Query: 361 LWEVATARCVRTVPVGGVVKSVAWNPSPAVCLVAAAVEDSVLLLNPALGDRLVAGSTDQL 420
LWEVATARCVRTVPVGGVVKSVAWNPSPAVCLVAAAVEDSVLLLNPALGDRLVAGSTDQL
Sbjct: 361 LWEVATARCVRTVPVGGVVKSVAWNPSPAVCLVAAAVEDSVLLLNPALGDRLVAGSTDQL 420
Query: 421 LSAFVPPEEPPLQPARWLEASEEERQVGLRLRICHGKPVTQVTWHGRGDYLAVVLATQGH 480
LSAFVPPEEPPLQPARWLEASEEERQVGLRLRICHGKPVTQVTWHGRGDYLAVVLATQGH
Sbjct: 421 LSAFVPPEEPPLQPARWLEASEEERQVGLRLRICHGKPVTQVTWHGRGDYLAVVLATQGH 480
Query: 481 TQVLIHQLSRRRSQSPFRRSHGQVQRVAFHPARPFLLVASQRSVRLYHLLRQELTKKLMP 540
TQVLIHQLSRRRSQSPFRRSHGQVQRVAFHPARPFLLVASQRSVRLYHLLRQELTKKLMP
Sbjct: 481 TQVLIHQLSRRRSQSPFRRSHGQVQRVAFHPARPFLLVASQRSVRLYHLLRQELTKKLMP 540
Query: 541 NCKWVSSLAVHPAGDNVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLF 600
NCKWVSSLAVHPAGDNVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLF
Sbjct: 541 NCKWVSSLAVHPAGDNVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLF 600
Query: 601 ASGSDDGSVIVCHGMVYNDLLQNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGA 660
ASGSDDGSVIVCHGMVYNDLLQNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGA
Sbjct: 601 ASGSDDGSVIVCHGMVYNDLLQNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGA 660
Query: 661 DGTVRLFT 668
DGTVRLFT
Sbjct: 661 DGTVRLFT 668
>gi|21327667 block of proliferation 1 [Homo sapiens]
Length = 746
Score = 1330 bits (3441), Expect = 0.0
Identities = 644/647 (99%), Positives = 644/647 (99%)
Query: 22 EPSPASTPCPRTEMASARIGDEYAEDSSDEEDIRNTVGNVPLEWYDDFPHVGYDLDGRRI 81
E ASTPCPRTEMASARIGDEYAEDSSDEEDIRNTVGNVPLEWYDDFPHVGYDLDGRRI
Sbjct: 100 EQVQASTPCPRTEMASARIGDEYAEDSSDEEDIRNTVGNVPLEWYDDFPHVGYDLDGRRI 159
Query: 82 YKPLRTRDELDQFLDKMDDPDYWRTVQDPMTGRDLRLTDEQVALVRRLQSGQFGDVGFNP 141
YKPLRTRDELDQFLDKMDDPDYWRTVQDPMTGRDLRLTDEQVALVRRLQSGQFGDVGFNP
Sbjct: 160 YKPLRTRDELDQFLDKMDDPDYWRTVQDPMTGRDLRLTDEQVALVRRLQSGQFGDVGFNP 219
Query: 142 YEPAVDFFSGDVMIHPVTNRPADKRSFIPSLVEKEKVSRMVHAIKMGWIQPRRPRDPTPS 201
YEPAVDFFSGDVMIHPVTNRPADKRSFIPSLVEKEKVSRMVHAIKMGWIQPRRPRDPTPS
Sbjct: 220 YEPAVDFFSGDVMIHPVTNRPADKRSFIPSLVEKEKVSRMVHAIKMGWIQPRRPRDPTPS 279
Query: 202 FYDLWAQEDPNAVLGRHKMHVPAPKLALPGHAESYNPPPEYLLSEEERLAWEQQEPGERK 261
FYDLWAQEDPNAVLGRHKMHVPAPKLALPGHAESYNPPPEYLLSEEERLAWEQQEPGERK
Sbjct: 280 FYDLWAQEDPNAVLGRHKMHVPAPKLALPGHAESYNPPPEYLLSEEERLAWEQQEPGERK 339
Query: 262 LSFLPRKFPSLRAVPAYGRFIQERFERCLDLYLCPRQRKMRVNVDPEDLIPKLPRPRDLQ 321
LSFLPRKFPSLRAVPAYGRFIQERFERCLDLYLCPRQRKMRVNVDPEDLIPKLPRPRDLQ
Sbjct: 340 LSFLPRKFPSLRAVPAYGRFIQERFERCLDLYLCPRQRKMRVNVDPEDLIPKLPRPRDLQ 399
Query: 322 PFPTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKS 381
PFPTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKS
Sbjct: 400 PFPTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKS 459
Query: 382 VAWNPSPAVCLVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEAS 441
VAWNPSPAVCLVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEAS
Sbjct: 460 VAWNPSPAVCLVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEAS 519
Query: 442 EEERQVGLRLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRSH 501
EEERQVGLRLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRSH
Sbjct: 520 EEERQVGLRLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRSH 579
Query: 502 GQVQRVAFHPARPFLLVASQRSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICGS 561
GQVQRVAFHPARPFLLVASQRSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICGS
Sbjct: 580 GQVQRVAFHPARPFLLVASQRSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICGS 639
Query: 562 YDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGMVYNDLL 621
YDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGMVYNDLL
Sbjct: 640 YDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGMVYNDLL 699
Query: 622 QNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADGTVRLFT 668
QNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADGTVRLFT
Sbjct: 700 QNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADGTVRLFT 746
>gi|51242945 striatin, calmodulin binding protein [Homo sapiens]
Length = 780
Score = 57.4 bits (137), Expect = 4e-08
Identities = 71/295 (24%), Positives = 114/295 (38%), Gaps = 33/295 (11%)
Query: 319 DLQPFPTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGV 378
D++P T +R H V C+ +S G+ SG DG ++ W P
Sbjct: 505 DVEPIYT-----FRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNID---PYDSY 556
Query: 379 VKSVAWNPSPAVCLVAAAVEDSVL-LLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARW 437
SV P D+V L A RL++ S D L + E P
Sbjct: 557 DPSVLRGP-------LLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPA----- 604
Query: 438 LEASEEERQVGL--RLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQS 495
L + +++G+ + + P V +G + TQ L + + S
Sbjct: 605 LSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSS 664
Query: 496 PFRRSHGQVQRVAFHPARPFLLVASQ-RSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAG 554
Q+ RV HP P + A + R ++ Y +L ++ + + V+SLAV P G
Sbjct: 665 C------QINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNG 718
Query: 555 DNVICGSYDSKLVWFDLDLSTKPYRMLRHHKK---ALRAVAFHPRYPLFASGSDD 606
++ GS+D + ++L+ T H KK ++ VAFHP AS D
Sbjct: 719 LYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGAD 773
Score = 42.4 bits (98), Expect = 0.001
Identities = 24/73 (32%), Positives = 40/73 (54%), Gaps = 7/73 (9%)
Query: 334 HSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPV-----GGVVKSVAWNPSP 388
H + V L+V P G +L+SGS D S+RLW + + C++ + VA++PS
Sbjct: 705 HLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSK 764
Query: 389 AVCLVAAAVEDSV 401
C +A+A D++
Sbjct: 765 --CYIASAGADAL 775
Score = 31.6 bits (70), Expect = 2.5
Identities = 42/175 (24%), Positives = 61/175 (34%), Gaps = 44/175 (25%)
Query: 499 RSHGQ-VQRVAFHPARPFLLVASQRSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNV 557
RSH ++ +AFHP P L+ AS+ H L+ +K P K S
Sbjct: 460 RSHFDGIRALAFHPIEPVLITASED-----HTLKMWNLQKTAPAKKSTS----------- 503
Query: 558 ICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGMVY 617
L +P R HK + V SG DG ++
Sbjct: 504 ---------------LDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDG-------LIQ 541
Query: 618 NDLLQNPLLVPV-----KVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADGTVRLF 667
NP + P VL+G +L V + + + S ADGT+RL+
Sbjct: 542 GWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLW 596
Score = 29.6 bits (65), Expect = 9.4
Identities = 13/30 (43%), Positives = 18/30 (60%)
Query: 577 PYRMLRHHKKALRAVAFHPRYPLFASGSDD 606
P LR H +RA+AFHP P+ + S+D
Sbjct: 455 PKFTLRSHFDGIRALAFHPIEPVLITASED 484
>gi|56243583 WD repeat domain 18 [Homo sapiens]
Length = 432
Score = 57.0 bits (136), Expect = 5e-08
Identities = 26/54 (48%), Positives = 38/54 (70%)
Query: 330 VYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVA 383
V++GH + V CLSVS G L+SGS D ++RLW+V + +C+RTV + G V + A
Sbjct: 264 VFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRTVALKGPVTNAA 317
Score = 29.6 bits (65), Expect = 9.4
Identities = 13/29 (44%), Positives = 21/29 (72%), Gaps = 1/29 (3%)
Query: 338 VRCLSVSPGGQWLVSGSDDGSLRLWEVAT 366
V CL+ SP G ++++G + S+ LWEV+T
Sbjct: 83 VTCLTASPNGLYVLAGVAE-SIHLWEVST 110
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 55.1 bits (131), Expect = 2e-07
Identities = 71/294 (24%), Positives = 109/294 (37%), Gaps = 52/294 (17%)
Query: 324 PTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVP-VGGVVKSV 382
P +A + GH D V C++ SP G L SGS D ++R+W VP V G +S
Sbjct: 50 PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW----------VPNVKG--EST 97
Query: 383 AWNPSPAVCLVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPL----QPARWL 438
+ A D G V S D+ + + + L Q W+
Sbjct: 98 VFRAHTATVRSVHFCSD---------GQSFVTASDDKTVKVWATHRQKFLFSLSQHINWV 148
Query: 439 EASEEERQVGLRLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFR 498
++ D +V A+ T V + S R +
Sbjct: 149 RCAKFS-----------------------PDGRLIVSASDDKT-VKLWDKSSRECVHSYC 184
Query: 499 RSHGQVQRVAFHPARPFLLVAS-QRSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNV 557
G V V FHP+ + A +V+++ + L + + V+ L+ HP+G+ +
Sbjct: 185 EHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYL 244
Query: 558 ICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIV 611
I S DS L DL + + L H+ VAF FASG D V+V
Sbjct: 245 ITASSDSTLKILDL-MEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 297
Score = 36.6 bits (83), Expect = 0.077
Identities = 37/171 (21%), Positives = 67/171 (39%), Gaps = 15/171 (8%)
Query: 497 FRRSHGQVQRVAF-HPARPFLLVASQRSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGD 555
FR V+ V F + F+ + ++V+++ RQ+ L + WV P G
Sbjct: 99 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 158
Query: 556 NVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGM 615
++ S D + +D S + H + V FHP A+ D +V V
Sbjct: 159 LIVSASDDKTVKLWDKS-SRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217
Query: 616 VYNDLLQNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADGTVRL 666
+ LLQ H V + FHP+ ++ ++ +D T+++
Sbjct: 218 THR-LLQ------------HYQLHSAAVNGLSFHPSGNYLITASSDSTLKI 255
Score = 30.8 bits (68), Expect = 4.2
Identities = 20/50 (40%), Positives = 27/50 (54%), Gaps = 1/50 (2%)
Query: 560 GSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSV 609
GS DS L+ + + ++ YR H K A+ V F P L ASGS D +V
Sbjct: 37 GSMDSCLMVWHMKPQSRAYRFTGH-KDAVTCVNFSPSGHLLASGSRDKTV 85
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 55.1 bits (131), Expect = 2e-07
Identities = 71/294 (24%), Positives = 109/294 (37%), Gaps = 52/294 (17%)
Query: 324 PTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVP-VGGVVKSV 382
P +A + GH D V C++ SP G L SGS D ++R+W VP V G +S
Sbjct: 50 PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW----------VPNVKG--EST 97
Query: 383 AWNPSPAVCLVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPL----QPARWL 438
+ A D G V S D+ + + + L Q W+
Sbjct: 98 VFRAHTATVRSVHFCSD---------GQSFVTASDDKTVKVWATHRQKFLFSLSQHINWV 148
Query: 439 EASEEERQVGLRLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFR 498
++ D +V A+ T V + S R +
Sbjct: 149 RCAKFS-----------------------PDGRLIVSASDDKT-VKLWDKSSRECVHSYC 184
Query: 499 RSHGQVQRVAFHPARPFLLVAS-QRSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNV 557
G V V FHP+ + A +V+++ + L + + V+ L+ HP+G+ +
Sbjct: 185 EHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYL 244
Query: 558 ICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIV 611
I S DS L DL + + L H+ VAF FASG D V+V
Sbjct: 245 ITASSDSTLKILDL-MEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 297
Score = 36.6 bits (83), Expect = 0.077
Identities = 37/171 (21%), Positives = 67/171 (39%), Gaps = 15/171 (8%)
Query: 497 FRRSHGQVQRVAF-HPARPFLLVASQRSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGD 555
FR V+ V F + F+ + ++V+++ RQ+ L + WV P G
Sbjct: 99 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 158
Query: 556 NVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGM 615
++ S D + +D S + H + V FHP A+ D +V V
Sbjct: 159 LIVSASDDKTVKLWDKS-SRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217
Query: 616 VYNDLLQNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADGTVRL 666
+ LLQ H V + FHP+ ++ ++ +D T+++
Sbjct: 218 THR-LLQ------------HYQLHSAAVNGLSFHPSGNYLITASSDSTLKI 255
Score = 30.8 bits (68), Expect = 4.2
Identities = 20/50 (40%), Positives = 27/50 (54%), Gaps = 1/50 (2%)
Query: 560 GSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSV 609
GS DS L+ + + ++ YR H K A+ V F P L ASGS D +V
Sbjct: 37 GSMDSCLMVWHMKPQSRAYRFTGH-KDAVTCVNFSPSGHLLASGSRDKTV 85
>gi|142976686 nuclear autoantigen isoform 1 [Homo sapiens]
Length = 797
Score = 55.1 bits (131), Expect = 2e-07
Identities = 62/292 (21%), Positives = 115/292 (39%), Gaps = 27/292 (9%)
Query: 319 DLQPFPTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGV 378
D++P T +R H V L++S G+ SG D +++ W + P V
Sbjct: 522 DVEPIYT-----FRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNM---------PSPSV 567
Query: 379 VKSVAWNPSPAVCLVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWL 438
+ P+ + + L + ++L++ S D + + P E+ P
Sbjct: 568 DPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEK---LPCICT 624
Query: 439 EASEEERQVGLRLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFR 498
+++ + + P VT G + L T +L Q+
Sbjct: 625 YNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGL------ 678
Query: 499 RSHGQVQRVAFHPARPFLLVASQ-RSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNV 557
+S+ + RV HP P + A + R ++ + ++ ++ + V+SLAV P G +
Sbjct: 679 QSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYL 738
Query: 558 ICGSYDSKLVWFDLDLSTKPYRMLRHHKK---ALRAVAFHPRYPLFASGSDD 606
+ GS+D + ++LD T + H KK ++ VAFH AS D
Sbjct: 739 MSGSHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGAD 790
Score = 40.8 bits (94), Expect = 0.004
Identities = 78/348 (22%), Positives = 133/348 (38%), Gaps = 40/348 (11%)
Query: 332 RGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAWNPSPAVC 391
R H D VR L+ P LV+ S+D +L+LW + +TVP KS + + P +
Sbjct: 477 RSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQ-----KTVPAK---KSASLDVEP-IY 527
Query: 392 LVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEASEEERQVGLRL 451
A + + L + G++ +G D + + P P + P E + V
Sbjct: 528 TFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPS-PSVDPYDTYEPN-----VLAGT 581
Query: 452 RICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFR--RSHGQVQRVAF 509
+ H V + + G + L + + T L + + + + HG V F
Sbjct: 582 LVGHTDAVWGLAYSGIKNQL--LSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDF 639
Query: 510 HPARPFLLVASQR--SVRLYHL--------LRQELTKKLMPNCKWVSSLAVHPAGDNVIC 559
P +V S S +Y L L ++ L N ++ + HP I
Sbjct: 640 IGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSN-NHINRVVSHPTLPVTIT 698
Query: 560 GSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGMVYND 619
D + +FD + M+ H A+ ++A P SGS D S+
Sbjct: 699 AHEDRHIKFFDNKTGKMIHSMVAH-LDAVTSLAVDPNGIYLMSGSHDCSI---------R 748
Query: 620 LLQNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADGTVRLF 667
L V+ + H D + DV FH ++ ++ S+GAD ++F
Sbjct: 749 LWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVF 796
Score = 30.4 bits (67), Expect = 5.5
Identities = 23/91 (25%), Positives = 40/91 (43%), Gaps = 6/91 (6%)
Query: 577 PYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGMVYNDLLQNPLL--VPVKVLKG 634
P LR H +RA+AFHP P+ + S+D ++ + + ++ L P+ +
Sbjct: 472 PKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRA 531
Query: 635 HVLTRDLGVLDVIFHPTQPWVFSSGADGTVR 665
H+ VL + FS G D T++
Sbjct: 532 HIGP----VLSLAISSNGEQCFSGGIDATIQ 558
>gi|142976675 nuclear autoantigen isoform 2 [Homo sapiens]
Length = 713
Score = 55.1 bits (131), Expect = 2e-07
Identities = 62/292 (21%), Positives = 115/292 (39%), Gaps = 27/292 (9%)
Query: 319 DLQPFPTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGV 378
D++P T +R H V L++S G+ SG D +++ W + P V
Sbjct: 438 DVEPIYT-----FRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNM---------PSPSV 483
Query: 379 VKSVAWNPSPAVCLVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWL 438
+ P+ + + L + ++L++ S D + + P E+ P
Sbjct: 484 DPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEK---LPCICT 540
Query: 439 EASEEERQVGLRLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFR 498
+++ + + P VT G + L T +L Q+
Sbjct: 541 YNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGL------ 594
Query: 499 RSHGQVQRVAFHPARPFLLVASQ-RSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNV 557
+S+ + RV HP P + A + R ++ + ++ ++ + V+SLAV P G +
Sbjct: 595 QSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYL 654
Query: 558 ICGSYDSKLVWFDLDLSTKPYRMLRHHKK---ALRAVAFHPRYPLFASGSDD 606
+ GS+D + ++LD T + H KK ++ VAFH AS D
Sbjct: 655 MSGSHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGAD 706
Score = 40.8 bits (94), Expect = 0.004
Identities = 78/348 (22%), Positives = 133/348 (38%), Gaps = 40/348 (11%)
Query: 332 RGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAWNPSPAVC 391
R H D VR L+ P LV+ S+D +L+LW + +TVP KS + + P +
Sbjct: 393 RSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQ-----KTVPAK---KSASLDVEP-IY 443
Query: 392 LVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEASEEERQVGLRL 451
A + + L + G++ +G D + + P P + P E + V
Sbjct: 444 TFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPS-PSVDPYDTYEPN-----VLAGT 497
Query: 452 RICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFR--RSHGQVQRVAF 509
+ H V + + G + L + + T L + + + + HG V F
Sbjct: 498 LVGHTDAVWGLAYSGIKNQL--LSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDF 555
Query: 510 HPARPFLLVASQR--SVRLYHL--------LRQELTKKLMPNCKWVSSLAVHPAGDNVIC 559
P +V S S +Y L L ++ L N ++ + HP I
Sbjct: 556 IGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSN-NHINRVVSHPTLPVTIT 614
Query: 560 GSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGMVYND 619
D + +FD + M+ H A+ ++A P SGS D S+
Sbjct: 615 AHEDRHIKFFDNKTGKMIHSMVAH-LDAVTSLAVDPNGIYLMSGSHDCSI---------R 664
Query: 620 LLQNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADGTVRLF 667
L V+ + H D + DV FH ++ ++ S+GAD ++F
Sbjct: 665 LWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVF 712
Score = 30.4 bits (67), Expect = 5.5
Identities = 23/91 (25%), Positives = 40/91 (43%), Gaps = 6/91 (6%)
Query: 577 PYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGMVYNDLLQNPLL--VPVKVLKG 634
P LR H +RA+AFHP P+ + S+D ++ + + ++ L P+ +
Sbjct: 388 PKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRA 447
Query: 635 HVLTRDLGVLDVIFHPTQPWVFSSGADGTVR 665
H+ VL + FS G D T++
Sbjct: 448 HIGP----VLSLAISSNGEQCFSGGIDATIQ 474
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 54.3 bits (129), Expect = 4e-07
Identities = 70/342 (20%), Positives = 133/342 (38%), Gaps = 63/342 (18%)
Query: 331 YRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVAT-ARCVRTVPVGGVVKSVAWNPSPA 389
++GH + L +SP G+ L + S D L LW AR R V VV SV ++P
Sbjct: 14 FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH-- 71
Query: 390 VCLVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEASEEERQVGL 449
G+ L + S D+ + ++P + +
Sbjct: 72 -------------------GNLLASASRDRTVRLWIPDKRGKFSEFK------------- 99
Query: 450 RLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRSHGQVQRVAF 509
H PV V + G +LA A++ + + +R S +R +H V+ F
Sbjct: 100 ----AHTAPVRSVDFSADGQFLAT--ASEDKSIKVWSMYRQRFLYSLYRHTH-WVRCAKF 152
Query: 510 HP-ARPFLLVASQRSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICGSYDSKLVW 568
P R + + ++++++ ++ + + + + +P+G + D +
Sbjct: 153 SPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKV 212
Query: 569 FDLDLSTKPYRMLRH---HKKALRAVAFHPRYPLFASGSDDGSVIVCHGMVYNDLLQNPL 625
+D+ ++ ++L+H H + ++FHP + S DG++ + DLL+ L
Sbjct: 213 WDVRVN----KLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKIL------DLLEGRL 262
Query: 626 LVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADGTVRLF 667
+ ++ G V T V F S GAD V L+
Sbjct: 263 IYTLQGHTGPVFT-------VSFSKGGELFASGGADTQVLLW 297
Score = 45.8 bits (107), Expect = 1e-04
Identities = 65/289 (22%), Positives = 116/289 (40%), Gaps = 42/289 (14%)
Query: 324 PTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVA 383
P +A Y GH D+V + SP G L S S D ++RLW +P K
Sbjct: 49 PHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLW----------IP----DKRGK 94
Query: 384 WNPSPAVCLVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEASEE 443
++ A +V+ S A G L S D+ + + +
Sbjct: 95 FSEFKAHTAPVRSVDFS------ADGQFLATASEDKSIKVW---------------SMYR 133
Query: 444 ERQVGLRLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRSHGQ 503
+R + R H + + GR ++++ + I + ++ + F S G
Sbjct: 134 QRFLYSLYRHTHWVRCAKFSPDGR-----LIVSCSEDKTIKIWDTTNKQCVNNFSDSVGF 188
Query: 504 VQRVAFHPARPFLLVA-SQRSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICGSY 562
V F+P+ + A S ++V+++ + +L + + V+ ++ HP+G+ +I S
Sbjct: 189 ANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASS 248
Query: 563 DSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIV 611
D L DL L + L+ H + V+F LFASG D V++
Sbjct: 249 DGTLKILDL-LEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLL 296
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 53.1 bits (126), Expect = 8e-07
Identities = 24/58 (41%), Positives = 36/58 (62%), Gaps = 1/58 (1%)
Query: 331 YRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVP-VGGVVKSVAWNPS 387
YRGHS VRCL SP G+WL S +DD +++LW++ + + P G V V ++P+
Sbjct: 143 YRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPN 200
Score = 50.1 bits (118), Expect = 7e-06
Identities = 44/166 (26%), Positives = 77/166 (46%), Gaps = 17/166 (10%)
Query: 504 VQRVAFHPARPFLLVASQR-SVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICGSY 562
V+ V + ++ SQ S+R++ L ++ + LM + + SL HP G+ V GS
Sbjct: 66 VESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQ 125
Query: 563 DSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGMVYNDLLQ 622
D+ + +D+ +R R H +A+R + F P AS +DD H + DL
Sbjct: 126 DTNIKLWDIRRKGCVFR-YRGHSQAVRCLRFSPDGKWLASAADD------HTVKLWDLTA 178
Query: 623 NPLLVPVKVLKGHVLTRDLGVLDVI-FHPTQPWVFSSGADGTVRLF 667
++ GH G ++V+ FHP + + S +D T+R +
Sbjct: 179 GKMM---SEFPGHT-----GPVNVVEFHPNEYLLASGSSDRTIRFW 216
Score = 38.9 bits (89), Expect = 0.015
Identities = 57/248 (22%), Positives = 100/248 (40%), Gaps = 46/248 (18%)
Query: 324 PTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVA 383
P C + GH+ V + ++ + +V+GS GS+R+W++ A+ +RT
Sbjct: 53 PNC-IMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRT----------- 100
Query: 384 WNPSPAVCLVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEASEE 443
L+ L +P G+ + +GS D + + +
Sbjct: 101 --------LMGHKANICSLDFHP-YGEFVASGSQDTNIKLW------------------D 133
Query: 444 ERQVGLRLRI-CHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRSHG 502
R+ G R H + V + + G +LA A HT V + L+ + S F G
Sbjct: 134 IRRKGCVFRYRGHSQAVRCLRFSPDGKWLA--SAADDHT-VKLWDLTAGKMMSEFPGHTG 190
Query: 503 QVQRVAFHPARPFLLV--ASQRSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICG 560
V V FHP +LL +S R++R + L + ++ + V S+ +P G + G
Sbjct: 191 PVNVVEFHP-NEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSG 249
Query: 561 SYDSKLVW 568
DS V+
Sbjct: 250 CQDSLRVY 257
Score = 34.7 bits (78), Expect = 0.29
Identities = 21/73 (28%), Positives = 38/73 (52%), Gaps = 4/73 (5%)
Query: 301 MRVNVDPEDLIPKLPRPRDLQPFPTCQALVYR---GHSDLVRCLSVSPGGQWLVSGSDDG 357
+R+N PE+LI + ++ + A + R GH + L P G+++ SGS D
Sbjct: 69 VRLNT-PEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDT 127
Query: 358 SLRLWEVATARCV 370
+++LW++ CV
Sbjct: 128 NIKLWDIRRKGCV 140
>gi|89886480 zinedin isoform 2 [Homo sapiens]
Length = 760
Score = 52.8 bits (125), Expect = 1e-06
Identities = 69/284 (24%), Positives = 108/284 (38%), Gaps = 32/284 (11%)
Query: 331 YRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAWNPSPAV 390
+R H V +++ ++ SG D + W++ + P G SV +
Sbjct: 494 FRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPD---LSMDPYDGYDPSVLSH----- 545
Query: 391 CLVAAAVEDSV--LLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEASEEERQVG 448
V D+V L +P RL + S D + + P P + ASE
Sbjct: 546 --VLEGHGDAVWGLAFSPT-SQRLASCSADGTVRIWDPSSSSPACLCTFPTASE------ 596
Query: 449 LRLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRSHG--QVQR 506
HG P T V + V G T + ++ R S G Q+ +
Sbjct: 597 ------HGVP-TSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQ 649
Query: 507 VAFHPARPFLLVA-SQRSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICGSYDSK 565
V HP +P + A R +R + ++ + V+ LAV P G ++ GS+D
Sbjct: 650 VVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCS 709
Query: 566 LVWFDLDLSTKPYRMLRH---HKKALRAVAFHPRYPLFASGSDD 606
L + LD T + H H++A+ AVA HP L AS D
Sbjct: 710 LRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGAD 753
Score = 49.7 bits (117), Expect = 9e-06
Identities = 29/73 (39%), Positives = 42/73 (57%), Gaps = 7/73 (9%)
Query: 334 HSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPV-----GGVVKSVAWNPSP 388
H D V CL+V P G +L+SGS D SLRLW + CV+ + + +VA +PS
Sbjct: 685 HLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSK 744
Query: 389 AVCLVAAAVEDSV 401
A L+A+A D++
Sbjct: 745 A--LIASAGADAL 755
Score = 44.3 bits (103), Expect = 4e-04
Identities = 30/95 (31%), Positives = 49/95 (51%), Gaps = 5/95 (5%)
Query: 324 PTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATA--RCVRTVPVG---GV 378
P+ + V GH D V L+ SP Q L S S DG++R+W+ +++ C+ T P GV
Sbjct: 540 PSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGV 599
Query: 379 VKSVAWNPSPAVCLVAAAVEDSVLLLNPALGDRLV 413
SVA+ + +VA+ +L + +G L+
Sbjct: 600 PTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALL 634
Score = 35.8 bits (81), Expect = 0.13
Identities = 78/346 (22%), Positives = 126/346 (36%), Gaps = 38/346 (10%)
Query: 332 RGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAWNPSPAVC 391
R H D +R L+ L++ S+DG+L+LW + A + V A+
Sbjct: 442 RSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPV 501
Query: 392 LVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEASEEERQVGLRL 451
L A +S + +G D + ++ P+ + P + S V +
Sbjct: 502 LAVAMGSNS---------EYCYSGGADACIHSWKIPDLS-MDPYDGYDPS-----VLSHV 546
Query: 452 RICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRS--HGQVQRVAF 509
HG V + + LA A G ++ S F + HG VAF
Sbjct: 547 LEGHGDAVWGLAFSPTSQRLASCSA-DGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAF 605
Query: 510 HPARPFLLVASQRS--VRLYH------LLRQELTKKLMPNCKWVSSLAVHPAGDNVICGS 561
P +VAS RS LY LL E P ++ + HP I
Sbjct: 606 TSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPT--QINQVVSHPNQPLTITAH 663
Query: 562 YDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGMVYNDLL 621
D + + D + + KP + H A+ +A P SGS D S+ + L
Sbjct: 664 DDRGIRFLD-NRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWS-------L 715
Query: 622 QNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADGTVRLF 667
N V + + H + + V HP++ + S+GAD ++F
Sbjct: 716 DNKTCV--QEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 759
>gi|89886477 zinedin isoform 1 [Homo sapiens]
Length = 753
Score = 52.8 bits (125), Expect = 1e-06
Identities = 69/284 (24%), Positives = 108/284 (38%), Gaps = 32/284 (11%)
Query: 331 YRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAWNPSPAV 390
+R H V +++ ++ SG D + W++ + P G SV +
Sbjct: 487 FRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPD---LSMDPYDGYDPSVLSH----- 538
Query: 391 CLVAAAVEDSV--LLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEASEEERQVG 448
V D+V L +P RL + S D + + P P + ASE
Sbjct: 539 --VLEGHGDAVWGLAFSPT-SQRLASCSADGTVRIWDPSSSSPACLCTFPTASE------ 589
Query: 449 LRLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRSHG--QVQR 506
HG P T V + V G T + ++ R S G Q+ +
Sbjct: 590 ------HGVP-TSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQ 642
Query: 507 VAFHPARPFLLVA-SQRSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICGSYDSK 565
V HP +P + A R +R + ++ + V+ LAV P G ++ GS+D
Sbjct: 643 VVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCS 702
Query: 566 LVWFDLDLSTKPYRMLRH---HKKALRAVAFHPRYPLFASGSDD 606
L + LD T + H H++A+ AVA HP L AS D
Sbjct: 703 LRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGAD 746
Score = 49.7 bits (117), Expect = 9e-06
Identities = 29/73 (39%), Positives = 42/73 (57%), Gaps = 7/73 (9%)
Query: 334 HSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPV-----GGVVKSVAWNPSP 388
H D V CL+V P G +L+SGS D SLRLW + CV+ + + +VA +PS
Sbjct: 678 HLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSK 737
Query: 389 AVCLVAAAVEDSV 401
A L+A+A D++
Sbjct: 738 A--LIASAGADAL 748
Score = 44.3 bits (103), Expect = 4e-04
Identities = 30/95 (31%), Positives = 49/95 (51%), Gaps = 5/95 (5%)
Query: 324 PTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATA--RCVRTVPVG---GV 378
P+ + V GH D V L+ SP Q L S S DG++R+W+ +++ C+ T P GV
Sbjct: 533 PSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGV 592
Query: 379 VKSVAWNPSPAVCLVAAAVEDSVLLLNPALGDRLV 413
SVA+ + +VA+ +L + +G L+
Sbjct: 593 PTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALL 627
Score = 35.8 bits (81), Expect = 0.13
Identities = 78/346 (22%), Positives = 126/346 (36%), Gaps = 38/346 (10%)
Query: 332 RGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAWNPSPAVC 391
R H D +R L+ L++ S+DG+L+LW + A + V A+
Sbjct: 435 RSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPV 494
Query: 392 LVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEASEEERQVGLRL 451
L A +S + +G D + ++ P+ + P + S V +
Sbjct: 495 LAVAMGSNS---------EYCYSGGADACIHSWKIPDLS-MDPYDGYDPS-----VLSHV 539
Query: 452 RICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRS--HGQVQRVAF 509
HG V + + LA A G ++ S F + HG VAF
Sbjct: 540 LEGHGDAVWGLAFSPTSQRLASCSA-DGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAF 598
Query: 510 HPARPFLLVASQRS--VRLYH------LLRQELTKKLMPNCKWVSSLAVHPAGDNVICGS 561
P +VAS RS LY LL E P ++ + HP I
Sbjct: 599 TSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPT--QINQVVSHPNQPLTITAH 656
Query: 562 YDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGMVYNDLL 621
D + + D + + KP + H A+ +A P SGS D S+ + L
Sbjct: 657 DDRGIRFLD-NRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWS-------L 708
Query: 622 QNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADGTVRLF 667
N V + + H + + V HP++ + S+GAD ++F
Sbjct: 709 DNKTCV--QEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752
>gi|19913369 transducin beta-like 3 [Homo sapiens]
Length = 808
Score = 52.0 bits (123), Expect = 2e-06
Identities = 87/356 (24%), Positives = 142/356 (39%), Gaps = 45/356 (12%)
Query: 341 LSVSPGGQWLVSGSDDGSLRLWEVATARCVRT--VPVGGVVKSVAWNPSPAVCLVAAAVE 398
L V G + ++ D G+LR+WE A+ +CV T P G + + +V A
Sbjct: 253 LGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATA 312
Query: 399 DSVLLLNPALGDRL---VAGSTDQLLSA-FVPPEEPPLQPARWLEASEEERQVGLRLRIC 454
D LLL A RL AG ++++L F+ PE+ + A + +I
Sbjct: 313 DHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQIL 372
Query: 455 HGKP--VTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRSHGQVQRV----A 508
HG V + +G A Q V I ++++ + G V
Sbjct: 373 HGHTDIVLALDVFRKGWLFASCAKDQ---SVRIWRMNKAGQVMCVAQGSGHTHSVGTVCC 429
Query: 509 FHPARPFLLVASQR-SVRLYHLLRQELTKKLMPN-------------C--KWVSSLAVHP 552
FL+ SQ +V+L+ L + L+K P+ C K ++S+A+ P
Sbjct: 430 SRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAP 489
Query: 553 AGDNVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVC 612
+ GS D + L + + H++ L V F P + A+ S DG++ +
Sbjct: 490 NDKLLATGSQDRTAKLWALP-QCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLW 548
Query: 613 HGMVYNDLLQNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADGTVRLFT 668
++ L K +GH D VL V F + SSG+DG V+L+T
Sbjct: 549 ALQDFSCL---------KTFEGH----DASVLKVAFVSRGTQLLSSGSDGLVKLWT 591
Score = 40.8 bits (94), Expect = 0.004
Identities = 21/58 (36%), Positives = 31/58 (53%), Gaps = 1/58 (1%)
Query: 316 RPRDLQPFPTCQAL-VYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRT 372
R L P CQ L V+ GH + C+ SP Q L + S DG+++LW + C++T
Sbjct: 501 RTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKT 558
Score = 36.2 bits (82), Expect = 0.10
Identities = 36/133 (27%), Positives = 57/133 (42%), Gaps = 8/133 (6%)
Query: 443 EERQVGLRLRICHGKPVTQVTWHGRGDYLAVVLATQG-HTQVLIHQLSRRRSQSPFRRSH 501
+E V + H PV + + D + +LAT G V + + R FR S
Sbjct: 96 QEGSVTRLWKAIHTAPVATMAF----DPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSP 151
Query: 502 GQVQRVAFHPARPFLLV---ASQRSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVI 558
G V VAFHP LL+ A+ ++R++ L + L + V+SLA G ++
Sbjct: 152 GVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTML 211
Query: 559 CGSYDSKLVWFDL 571
D + +DL
Sbjct: 212 SSGRDKICIIWDL 224
Score = 33.1 bits (74), Expect = 0.85
Identities = 20/72 (27%), Positives = 36/72 (50%), Gaps = 5/72 (6%)
Query: 334 HSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVAT---ARCVRTVPVGGVVKSVAWNPSPAV 390
H+ V ++ P L +G DG++R+W++ R P GVV VA++P P
Sbjct: 108 HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSP--GVVHLVAFHPDPTR 165
Query: 391 CLVAAAVEDSVL 402
L+ ++ D+ +
Sbjct: 166 LLLFSSATDAAI 177
Score = 33.1 bits (74), Expect = 0.85
Identities = 18/44 (40%), Positives = 27/44 (61%), Gaps = 2/44 (4%)
Query: 331 YRGH-SDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTV 373
+ GH + +++ VS G Q L SGSD G ++LW + CVRT+
Sbjct: 559 FEGHDASVLKVAFVSRGTQLLSSGSD-GLVKLWTIKNNECVRTL 601
Score = 30.4 bits (67), Expect = 5.5
Identities = 17/61 (27%), Positives = 27/61 (44%)
Query: 330 VYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAWNPSPA 389
V H V L+ S G ++S D +W++ + + RTVPV V++ P
Sbjct: 190 VLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLPEEP 249
Query: 390 V 390
V
Sbjct: 250 V 250
Score = 30.4 bits (67), Expect = 5.5
Identities = 19/51 (37%), Positives = 25/51 (49%), Gaps = 2/51 (3%)
Query: 326 CQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVG 376
CQ L GH+D+V L V G S + D S+R+W + A V V G
Sbjct: 369 CQIL--HGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQG 417
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 51.6 bits (122), Expect = 2e-06
Identities = 36/113 (31%), Positives = 58/113 (51%), Gaps = 5/113 (4%)
Query: 498 RRSHGQVQRVA---FHPARPFLLVASQRSV-RLYHLLRQELTKKLMPNCKWVSSLAVHPA 553
R HG + V HP L+ S+ S R++ + + L + V+++ A
Sbjct: 282 RHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAA 341
Query: 554 GDNVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDD 606
+I GS+D+ + +DL ++ K L +HKK++RAV HPR+ FASGS D
Sbjct: 342 EPQIITGSHDTTIRLWDL-VAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPD 393
Score = 50.4 bits (119), Expect = 5e-06
Identities = 21/57 (36%), Positives = 37/57 (64%), Gaps = 2/57 (3%)
Query: 312 PKLPRPRDLQPFPTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATAR 368
P +P+P+ P+ + V GH VRC++V PG QW V+GS D ++++W++A+ +
Sbjct: 183 PTMPKPQWHPPWKLYR--VISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGK 237
Score = 36.2 bits (82), Expect = 0.10
Identities = 34/125 (27%), Positives = 52/125 (41%), Gaps = 16/125 (12%)
Query: 544 WVSSLAVHPAGDNVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYP-LFAS 602
WV +AV P + GS D + +DL S K L H +R V R P LF+
Sbjct: 206 WVRCIAVEPGNQWFVTGSADRTIKIWDL-ASGKLKLSLTGHISTVRGVIVSTRSPYLFSC 264
Query: 603 GSDDGSVIVCHGMVYNDLLQNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADG 662
G D + C + YN ++++ GH+ V + HPT + + D
Sbjct: 265 GED--KQVKCWDLEYNKVIRH--------YHGHL----SAVYGLDLHPTIDVLVTCSRDS 310
Query: 663 TVRLF 667
T R++
Sbjct: 311 TARIW 315
Score = 32.7 bits (73), Expect = 1.1
Identities = 27/90 (30%), Positives = 40/90 (44%), Gaps = 13/90 (14%)
Query: 576 KPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGMVYNDLLQNPLLVPVKVLKGH 635
K YR++ H +R +A P F +GS D ++ + DL L + L GH
Sbjct: 195 KLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIW------DLASGKLKLS---LTGH 245
Query: 636 VLTRDLGVLDVIFHPTQPWVFSSGADGTVR 665
+ T V VI P++FS G D V+
Sbjct: 246 IST----VRGVIVSTRSPYLFSCGEDKQVK 271
Score = 31.6 bits (70), Expect = 2.5
Identities = 14/34 (41%), Positives = 24/34 (70%), Gaps = 1/34 (2%)
Query: 333 GHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVAT 366
GH+ ++ L+V+ G LVSG+D+G++ LW+ T
Sbjct: 411 GHNAIINTLTVNSDGV-LVSGADNGTMHLWDWRT 443
Score = 30.8 bits (68), Expect = 4.2
Identities = 16/43 (37%), Positives = 22/43 (51%)
Query: 331 YRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTV 373
Y GH V L + P LV+ S D + R+W+V T V T+
Sbjct: 284 YHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTL 326
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 50.8 bits (120), Expect = 4e-06
Identities = 26/69 (37%), Positives = 43/69 (62%), Gaps = 2/69 (2%)
Query: 334 HSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRT-VPVGGVVKSVAWNPSPAVCL 392
H + VRC SP G+ +VS SDD +++LW+ ++ CV + GG V V ++PS C+
Sbjct: 106 HINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPS-GTCI 164
Query: 393 VAAAVEDSV 401
AA ++++V
Sbjct: 165 AAAGMDNTV 173
Score = 48.5 bits (114), Expect = 2e-05
Identities = 68/297 (22%), Positives = 107/297 (36%), Gaps = 58/297 (19%)
Query: 324 PTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVA 383
P +A + GH D V C++ SP G L SGS D +TV +
Sbjct: 12 PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRD--------------KTVRI-------- 49
Query: 384 WNPS----PAVCLVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPL----QPA 435
W P+ V A SV + G V S D+ + + + L Q
Sbjct: 50 WVPNVKGESTVFRAHTATVRSVHFCSD--GQSFVTASDDKTVKVWATHRQKFLFSLSQHI 107
Query: 436 RWLEASEEERQVGLRLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQS 495
W+ ++ GR ++++ V + S R
Sbjct: 108 NWVRCAKFSPD-------------------GR-----LIVSASDDKTVKLWDKSSRECVH 143
Query: 496 PFRRSHGQVQRVAFHPARPFLLVASQ-RSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAG 554
+ G V V FHP+ + A +V+++ + L + + V+ L+ HP+G
Sbjct: 144 SYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSG 203
Query: 555 DNVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIV 611
+ +I S DS L DL + + L H+ VAF FASG D V+V
Sbjct: 204 NYLITASSDSTLKILDL-MEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 259
Score = 36.6 bits (83), Expect = 0.077
Identities = 37/171 (21%), Positives = 67/171 (39%), Gaps = 15/171 (8%)
Query: 497 FRRSHGQVQRVAF-HPARPFLLVASQRSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGD 555
FR V+ V F + F+ + ++V+++ RQ+ L + WV P G
Sbjct: 61 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120
Query: 556 NVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGM 615
++ S D + +D S + H + V FHP A+ D +V V
Sbjct: 121 LIVSASDDKTVKLWDKS-SRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 179
Query: 616 VYNDLLQNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADGTVRL 666
+ LLQ H V + FHP+ ++ ++ +D T+++
Sbjct: 180 THR-LLQ------------HYQLHSAAVNGLSFHPSGNYLITASSDSTLKI 217
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 50.4 bits (119), Expect = 5e-06
Identities = 81/356 (22%), Positives = 141/356 (39%), Gaps = 47/356 (13%)
Query: 333 GHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVP-VGGVVKSVAWNPSPAVC 391
GHS+ V ++ SP G++L SGS D ++R W+++T T V S++W+P
Sbjct: 112 GHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRK- 170
Query: 392 LVAAAVEDSVLLLNPALG---DRLVAGSTDQLLS-AFVPPEEPPLQPARWLEASEEERQV 447
L + +LL +P+ G R +AG + + ++ P P R++ +S ++ V
Sbjct: 171 LASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANP--ECRYVASSSKDGSV 228
Query: 448 GL---------RLRICHGKPVTQVTWHGRGDYLA-----VVLATQGHTQVLIHQLSRRRS 493
+ R+ H + VT + W G G + + + H VL L
Sbjct: 229 RIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGH 288
Query: 494 --QSPFRRSHGQVQRVAFHPARPFLLVASQRSVRLYHLLRQELTKKLMPNCKWVSSLAVH 551
+ + ++ AF PA AS L L QEL ++ + V
Sbjct: 289 WVNTMALSTDYALRTGAFEPAE-----ASVNPQDLQGSL-QELKERALSRYNLVRG---- 338
Query: 552 PAGDNVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIV 611
+ ++ GS D L + KP + H+ + V F P + AS S D S+ +
Sbjct: 339 QGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKL 398
Query: 612 CHGMVYNDLLQNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADGTVRLF 667
G L L+GHV V + + + S +D T++++
Sbjct: 399 WDGRTGKYLAS---------LRGHV----AAVYQIAWSADSRLLVSGSSDSTLKVW 441
Score = 34.7 bits (78), Expect = 0.29
Identities = 19/56 (33%), Positives = 30/56 (53%), Gaps = 1/56 (1%)
Query: 332 RGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVP-VGGVVKSVAWNP 386
RGH V ++ S + LVSGS D +L++W+V + +P V +V W+P
Sbjct: 411 RGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSP 466
Score = 33.1 bits (74), Expect = 0.85
Identities = 32/134 (23%), Positives = 60/134 (44%), Gaps = 10/134 (7%)
Query: 535 TKKLMPNCKWVSSLAVHPAGDNVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFH 594
T L + + V S+A P G + GS D+ + ++DL T P+ + H+ + ++++
Sbjct: 107 TSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTET-PHFTCKGHRHWVLSISWS 165
Query: 595 PRYPLFASGSDDGSVIVCHGMVYNDLLQNPLLVPVKVLKGH-VLTRDLGVLDVIFHPTQP 653
P ASG +G +++ + + L GH L + +P
Sbjct: 166 PDGRKLASGCKNGQILLWDPSTGKQV--------GRTLAGHSKWITGLSWEPLHANPECR 217
Query: 654 WVFSSGADGTVRLF 667
+V SS DG+VR++
Sbjct: 218 YVASSSKDGSVRIW 231
Score = 32.0 bits (71), Expect = 1.9
Identities = 14/30 (46%), Positives = 18/30 (60%)
Query: 333 GHSDLVRCLSVSPGGQWLVSGSDDGSLRLW 362
GH+D V + SP GQ + SG D LR+W
Sbjct: 454 GHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 29.6 bits (65), Expect = 9.4
Identities = 32/102 (31%), Positives = 50/102 (49%), Gaps = 11/102 (10%)
Query: 317 PRDLQPFPTCQALVYRGHS--DLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVP 374
P+DLQ + Q L R S +LVR G + LVSGSDD +L LW A + T
Sbjct: 315 PQDLQG--SLQELKERALSRYNLVR----GQGPERLVSGSDDFTLFLWSPAEDKKPLTRM 368
Query: 375 VG--GVVKSVAWNPSPAVCLVAAAVEDSVLLLNPALGDRLVA 414
G ++ V ++P + + +A+ + S+ L + G L +
Sbjct: 369 TGHQALINQVLFSPDSRI-VASASFDKSIKLWDGRTGKYLAS 409
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 49.7 bits (117), Expect = 9e-06
Identities = 29/102 (28%), Positives = 55/102 (53%), Gaps = 11/102 (10%)
Query: 332 RGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPV-GGVVKSVAWNPSPAV 390
+GHS+ V C + +P +VSGS D S+R+W+V T +C++T+P V +V +N ++
Sbjct: 126 KGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSL 185
Query: 391 CLVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPL 432
+V+++ + + + A G Q L + + PP+
Sbjct: 186 -IVSSSYDGLCRIWDTASG---------QCLKTLIDDDNPPV 217
Score = 39.7 bits (91), Expect = 0.009
Identities = 24/78 (30%), Positives = 39/78 (50%), Gaps = 4/78 (5%)
Query: 331 YRGHSDLVRCLSVS---PGGQWLVSGSDDGSLRLWEVATARCVRTVP-VGGVVKSVAWNP 386
Y GH + C+ + GG+W+VSGS+D + +W + T V+ + VV S A +P
Sbjct: 252 YTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP 311
Query: 387 SPAVCLVAAAVEDSVLLL 404
+ + AA D + L
Sbjct: 312 TENIIASAALENDKTIKL 329
Score = 37.4 bits (85), Expect = 0.045
Identities = 21/78 (26%), Positives = 42/78 (53%), Gaps = 2/78 (2%)
Query: 333 GHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGV-VKSVAWNPSPAVC 391
GH+ V + SP G+WL S S D +++W + +T+ + + VAW+ S +
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS-SDSNL 101
Query: 392 LVAAAVEDSVLLLNPALG 409
LV+A+ + ++ + + + G
Sbjct: 102 LVSASDDKTLKIWDVSSG 119
Score = 34.7 bits (78), Expect = 0.29
Identities = 14/41 (34%), Positives = 27/41 (65%)
Query: 333 GHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTV 373
GH + ++ S LVS SDD +L++W+V++ +C++T+
Sbjct: 85 GHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL 125
Score = 31.6 bits (70), Expect = 2.5
Identities = 10/35 (28%), Positives = 24/35 (68%)
Query: 338 VRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRT 372
V + SP G+++++ + D +L+LW+ + +C++T
Sbjct: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKT 251
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 49.7 bits (117), Expect = 9e-06
Identities = 29/102 (28%), Positives = 55/102 (53%), Gaps = 11/102 (10%)
Query: 332 RGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPV-GGVVKSVAWNPSPAV 390
+GHS+ V C + +P +VSGS D S+R+W+V T +C++T+P V +V +N ++
Sbjct: 126 KGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSL 185
Query: 391 CLVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPL 432
+V+++ + + + A G Q L + + PP+
Sbjct: 186 -IVSSSYDGLCRIWDTASG---------QCLKTLIDDDNPPV 217
Score = 39.7 bits (91), Expect = 0.009
Identities = 24/78 (30%), Positives = 39/78 (50%), Gaps = 4/78 (5%)
Query: 331 YRGHSDLVRCLSVS---PGGQWLVSGSDDGSLRLWEVATARCVRTVP-VGGVVKSVAWNP 386
Y GH + C+ + GG+W+VSGS+D + +W + T V+ + VV S A +P
Sbjct: 252 YTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP 311
Query: 387 SPAVCLVAAAVEDSVLLL 404
+ + AA D + L
Sbjct: 312 TENIIASAALENDKTIKL 329
Score = 37.4 bits (85), Expect = 0.045
Identities = 21/78 (26%), Positives = 42/78 (53%), Gaps = 2/78 (2%)
Query: 333 GHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGV-VKSVAWNPSPAVC 391
GH+ V + SP G+WL S S D +++W + +T+ + + VAW+ S +
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS-SDSNL 101
Query: 392 LVAAAVEDSVLLLNPALG 409
LV+A+ + ++ + + + G
Sbjct: 102 LVSASDDKTLKIWDVSSG 119
Score = 34.7 bits (78), Expect = 0.29
Identities = 14/41 (34%), Positives = 27/41 (65%)
Query: 333 GHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTV 373
GH + ++ S LVS SDD +L++W+V++ +C++T+
Sbjct: 85 GHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL 125
Score = 31.6 bits (70), Expect = 2.5
Identities = 10/35 (28%), Positives = 24/35 (68%)
Query: 338 VRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRT 372
V + SP G+++++ + D +L+LW+ + +C++T
Sbjct: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKT 251
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 49.3 bits (116), Expect = 1e-05
Identities = 62/295 (21%), Positives = 111/295 (37%), Gaps = 68/295 (23%)
Query: 319 DLQPFPTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGV 378
D Q F + + GH V +++ P G +VS S D ++++WEV T CV+T
Sbjct: 178 DFQGFECIRTM--HGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTF----- 230
Query: 379 VKSVAWNPSPAVCLVAAAVEDSVLLLNPALGDRLVAG-STDQLLSAFVPPEEPPLQPARW 437
+ V ++ P L+A S DQ + +V +
Sbjct: 231 ----------------TGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATK-------- 266
Query: 438 LEASEEERQVGLRLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPF 497
E E R+ H V ++W Y ++ AT T ++S P
Sbjct: 267 -ECKAELRE--------HEHVVECISWAPESSYSSISEATGSET---------KKSGKP- 307
Query: 498 RRSHGQVQRVAFHPARPFLLVASQ-RSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDN 556
PFLL S+ ++++++ + L+ + WV + H G
Sbjct: 308 ---------------GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKF 352
Query: 557 VICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIV 611
++ + D L +D + + + L H+ + ++ FH P +GS D +V V
Sbjct: 353 ILSCADDKTLRVWDYK-NKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKV 406
Score = 35.4 bits (80), Expect = 0.17
Identities = 32/158 (20%), Positives = 71/158 (44%), Gaps = 5/158 (3%)
Query: 455 HGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRSHGQVQRVAF-HPAR 513
H PVT+V +H +V+++ + + + + VQ ++F H +
Sbjct: 107 HRSPVTRVIFH---PVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK 163
Query: 514 PFLLVASQRSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICGSYDSKLVWFDLDL 573
++ +++L+ E + + + VSS+A+ P GD+++ S D + +++
Sbjct: 164 LLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQ- 222
Query: 574 STKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIV 611
+ + H++ +R V + L AS S+D +V V
Sbjct: 223 TGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRV 260
>gi|148536855 coatomer protein complex, subunit alpha isoform 1
[Homo sapiens]
Length = 1233
Score = 48.1 bits (113), Expect = 3e-05
Identities = 46/172 (26%), Positives = 73/172 (42%), Gaps = 15/172 (8%)
Query: 497 FRRSHGQVQRVAFHPARPFLLVASQRSV-RLYHLLRQELTKKLMPNCKWVSSLAVHPAGD 555
F +V+ ++FHP RP++L + V +L+ L K + V + H
Sbjct: 5 FETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQP 64
Query: 556 NVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGM 615
+ G D K+ ++ L + +L H +R FH YP S SDD ++ V +
Sbjct: 65 LFVSGGDDYKIKVWNYKLRRCLFTLL-GHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQ 123
Query: 616 VYNDLLQNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADGTVRLF 667
V VL GH + V+ FHPT+ V S+ D TVR++
Sbjct: 124 ---------SRTCVCVLTGH----NHYVMCAQFHPTEDLVVSASLDQTVRVW 162
Score = 43.9 bits (102), Expect = 5e-04
Identities = 42/192 (21%), Positives = 75/192 (39%), Gaps = 39/192 (20%)
Query: 504 VQRVAFHPARPFLLVASQ-RSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICGSY 562
++ FH P++L AS +++R+++ + L + +V HP D V+ S
Sbjct: 96 IRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASL 155
Query: 563 DSKLVWFDL-----------------------DLSTKPYRMLRH----HKKALRAVAFHP 595
D + +D+ DL +++H H + + AFHP
Sbjct: 156 DQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHP 215
Query: 596 RYPLFASGSDDGSVIVCHGMVYNDLLQNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWV 655
PL SG+DD V + + V +GH V +FHP Q +
Sbjct: 216 TMPLIVSGADDRQVKIWR-------MNESKAWEVDTCRGHY----NNVSCAVFHPRQELI 264
Query: 656 FSSGADGTVRLF 667
S+ D ++R++
Sbjct: 265 LSNSEDKSIRVW 276
Score = 42.7 bits (99), Expect = 0.001
Identities = 56/283 (19%), Positives = 98/283 (34%), Gaps = 62/283 (21%)
Query: 333 GHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAWNPSPAVCL 392
GH D +R W++S SDD ++R+W W VC+
Sbjct: 91 GHLDYIRTTFFHHEYPWILSASDDQTIRVWN--------------------WQSRTCVCV 130
Query: 393 VAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEASEEERQVGLRLR 452
+ + D +V+ S DQ + W + ++ +
Sbjct: 131 LTGHNHYVMCAQFHPTEDLVVSASLDQTVRV-------------WDISGLRKKNLSPGAV 177
Query: 453 ICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRSHGQVQRVAFHPA 512
+ +T V G D + V +GH + V AFHP
Sbjct: 178 ESDVRGITGVDLFGTTDAV-VKHVLEGHDR--------------------GVNWAAFHPT 216
Query: 513 RPFLLV-ASQRSVRLYHLLRQELTKKLMPNCKW----VSSLAVHPAGDNVICGSYDSKLV 567
P ++ A R V+++ + + + + C+ VS HP + ++ S D +
Sbjct: 217 MPLIVSGADDRQVKIWRMNESKAWE--VDTCRGHYNNVSCAVFHPRQELILSNSEDKSIR 274
Query: 568 WFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVI 610
+D+ T R H + +A HP LFA+G D G ++
Sbjct: 275 VWDMSKRTGVQTFRRDHDR-FWVLAAHPNLNLFAAGHDGGMIV 316
Score = 32.7 bits (73), Expect = 1.1
Identities = 45/197 (22%), Positives = 76/197 (38%), Gaps = 31/197 (15%)
Query: 325 TCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAW 384
TC V GH+ V C P +VS S D ++R+W+++ R P G V V
Sbjct: 126 TC-VCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSP-GAVESDVRG 183
Query: 385 NPSPAVCLVAAAVEDSVL----------LLNPALGDRLVAGSTDQLLSAFVPPEEPPLQP 434
+ AV VL +P + +V+G+ D+ + + E
Sbjct: 184 ITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTM-PLIVSGADDRQVKIWRMNES----- 237
Query: 435 ARWLEASEEERQVGLRLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQ 494
+A E + G H V+ +H R + ++L+ + + +S+R
Sbjct: 238 ----KAWEVDTCRG------HYNNVSCAVFHPRQE---LILSNSEDKSIRVWDMSKRTGV 284
Query: 495 SPFRRSHGQVQRVAFHP 511
FRR H + +A HP
Sbjct: 285 QTFRRDHDRFWVLAAHP 301
>gi|148536853 coatomer protein complex, subunit alpha isoform 2
[Homo sapiens]
Length = 1224
Score = 48.1 bits (113), Expect = 3e-05
Identities = 46/172 (26%), Positives = 73/172 (42%), Gaps = 15/172 (8%)
Query: 497 FRRSHGQVQRVAFHPARPFLLVASQRSV-RLYHLLRQELTKKLMPNCKWVSSLAVHPAGD 555
F +V+ ++FHP RP++L + V +L+ L K + V + H
Sbjct: 5 FETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQP 64
Query: 556 NVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGM 615
+ G D K+ ++ L + +L H +R FH YP S SDD ++ V +
Sbjct: 65 LFVSGGDDYKIKVWNYKLRRCLFTLL-GHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQ 123
Query: 616 VYNDLLQNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADGTVRLF 667
V VL GH + V+ FHPT+ V S+ D TVR++
Sbjct: 124 ---------SRTCVCVLTGH----NHYVMCAQFHPTEDLVVSASLDQTVRVW 162
Score = 43.9 bits (102), Expect = 5e-04
Identities = 42/192 (21%), Positives = 75/192 (39%), Gaps = 39/192 (20%)
Query: 504 VQRVAFHPARPFLLVASQ-RSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICGSY 562
++ FH P++L AS +++R+++ + L + +V HP D V+ S
Sbjct: 96 IRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASL 155
Query: 563 DSKLVWFDL-----------------------DLSTKPYRMLRH----HKKALRAVAFHP 595
D + +D+ DL +++H H + + AFHP
Sbjct: 156 DQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHP 215
Query: 596 RYPLFASGSDDGSVIVCHGMVYNDLLQNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWV 655
PL SG+DD V + + V +GH V +FHP Q +
Sbjct: 216 TMPLIVSGADDRQVKIWR-------MNESKAWEVDTCRGHY----NNVSCAVFHPRQELI 264
Query: 656 FSSGADGTVRLF 667
S+ D ++R++
Sbjct: 265 LSNSEDKSIRVW 276
Score = 42.7 bits (99), Expect = 0.001
Identities = 56/283 (19%), Positives = 98/283 (34%), Gaps = 62/283 (21%)
Query: 333 GHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAWNPSPAVCL 392
GH D +R W++S SDD ++R+W W VC+
Sbjct: 91 GHLDYIRTTFFHHEYPWILSASDDQTIRVWN--------------------WQSRTCVCV 130
Query: 393 VAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEASEEERQVGLRLR 452
+ + D +V+ S DQ + W + ++ +
Sbjct: 131 LTGHNHYVMCAQFHPTEDLVVSASLDQTVRV-------------WDISGLRKKNLSPGAV 177
Query: 453 ICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRSHGQVQRVAFHPA 512
+ +T V G D + V +GH + V AFHP
Sbjct: 178 ESDVRGITGVDLFGTTDAV-VKHVLEGHDR--------------------GVNWAAFHPT 216
Query: 513 RPFLLV-ASQRSVRLYHLLRQELTKKLMPNCKW----VSSLAVHPAGDNVICGSYDSKLV 567
P ++ A R V+++ + + + + C+ VS HP + ++ S D +
Sbjct: 217 MPLIVSGADDRQVKIWRMNESKAWE--VDTCRGHYNNVSCAVFHPRQELILSNSEDKSIR 274
Query: 568 WFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVI 610
+D+ T R H + +A HP LFA+G D G ++
Sbjct: 275 VWDMSKRTGVQTFRRDHDR-FWVLAAHPNLNLFAAGHDGGMIV 316
Score = 32.7 bits (73), Expect = 1.1
Identities = 45/197 (22%), Positives = 76/197 (38%), Gaps = 31/197 (15%)
Query: 325 TCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAW 384
TC V GH+ V C P +VS S D ++R+W+++ R P G V V
Sbjct: 126 TC-VCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSP-GAVESDVRG 183
Query: 385 NPSPAVCLVAAAVEDSVL----------LLNPALGDRLVAGSTDQLLSAFVPPEEPPLQP 434
+ AV VL +P + +V+G+ D+ + + E
Sbjct: 184 ITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTM-PLIVSGADDRQVKIWRMNES----- 237
Query: 435 ARWLEASEEERQVGLRLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQ 494
+A E + G H V+ +H R + ++L+ + + +S+R
Sbjct: 238 ----KAWEVDTCRG------HYNNVSCAVFHPRQE---LILSNSEDKSIRVWDMSKRTGV 284
Query: 495 SPFRRSHGQVQRVAFHP 511
FRR H + +A HP
Sbjct: 285 QTFRRDHDRFWVLAAHP 301
>gi|215272341 WD repeat domain 58 isoform 2 [Homo sapiens]
Length = 296
Score = 47.4 bits (111), Expect = 4e-05
Identities = 19/46 (41%), Positives = 33/46 (71%)
Query: 330 VYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPV 375
V RGH+D + CL++ ++SG +DG++RLW++ TA+ V+T+ V
Sbjct: 163 VLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQTIEV 208
Score = 33.5 bits (75), Expect = 0.65
Identities = 20/65 (30%), Positives = 34/65 (52%), Gaps = 1/65 (1%)
Query: 545 VSSLAVHPAGDNVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGS 604
+++L + P +++I D +L DL+ T R+LR H + +A R P SG
Sbjct: 129 INALLLVPKENSLILAGGDCQLHTMDLETGTFT-RVLRGHTDYIHCLALRERSPEVLSGG 187
Query: 605 DDGSV 609
+DG+V
Sbjct: 188 EDGAV 192
>gi|31543164 WD repeat domain 58 isoform 1 [Homo sapiens]
Length = 341
Score = 47.4 bits (111), Expect = 4e-05
Identities = 19/46 (41%), Positives = 33/46 (71%)
Query: 330 VYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPV 375
V RGH+D + CL++ ++SG +DG++RLW++ TA+ V+T+ V
Sbjct: 163 VLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQTIEV 208
Score = 33.5 bits (75), Expect = 0.65
Identities = 20/65 (30%), Positives = 34/65 (52%), Gaps = 1/65 (1%)
Query: 545 VSSLAVHPAGDNVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGS 604
+++L + P +++I D +L DL+ T R+LR H + +A R P SG
Sbjct: 129 INALLLVPKENSLILAGGDCQLHTMDLETGTFT-RVLRGHTDYIHCLALRERSPEVLSGG 187
Query: 605 DDGSV 609
+DG+V
Sbjct: 188 EDGAV 192
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 46.6 bits (109), Expect = 7e-05
Identities = 28/102 (27%), Positives = 53/102 (51%), Gaps = 11/102 (10%)
Query: 332 RGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPV-GGVVKSVAWNPSPAV 390
+GHS+ V C + +P ++SGS D ++++WEV T +C++T+ V +V +N S +
Sbjct: 122 KGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGS- 180
Query: 391 CLVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPL 432
L+ + D + R+ ++ Q L V + PP+
Sbjct: 181 -LIVSGSYDGLC--------RIWDAASGQCLKTLVDDDNPPV 213
Score = 37.0 bits (84), Expect = 0.059
Identities = 61/282 (21%), Positives = 117/282 (41%), Gaps = 14/282 (4%)
Query: 333 GHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGV-VKSVAWNPSPAVC 391
GH++ V + SP G+WL S S D + +W + +T+ + + VAW+ S +
Sbjct: 39 GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWS-SDSSR 97
Query: 392 LVAAAVEDSVLLLNPALGD--RLVAGSTDQLLSA-FVPPEEPPLQPA--RWLEASEEERQ 446
LV+A+ + ++ L + G + + G ++ + F PP + + ++ E +
Sbjct: 98 LVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTG 157
Query: 447 VGLRLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRSHGQVQR 506
L+ H PV+ V ++ G +V + + S + ++ + V
Sbjct: 158 KCLKTLSAHSDPVSAVHFNCSGS--LIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSF 215
Query: 507 VAFHPARPFLLVAS-QRSVRLYHLLRQELTKKLM--PNCKWVSSLAVHPAGDNVICGSYD 563
V F P ++L A+ +++L+ R K N K+ G I +
Sbjct: 216 VKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSE 275
Query: 564 SKLVWFDLDLSTKP-YRMLRHHKKALRAVAFHPRYPLFASGS 604
LV+ +L TK + L+ H + + A HP L AS +
Sbjct: 276 DNLVYI-WNLQTKEIVQKLQGHTDVVISAACHPTENLIASAA 316
>gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]
Length = 1336
Score = 46.2 bits (108), Expect = 1e-04
Identities = 54/238 (22%), Positives = 95/238 (39%), Gaps = 42/238 (17%)
Query: 330 VYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGV-VKSVAWNPSP 388
+++ H + +R S SP + SDDG++R+W+ R + G VK V W+P+
Sbjct: 197 MFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGADVKCVDWHPTK 256
Query: 389 AVCLVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEASEEERQVG 448
+ +V+GS D QP ++ + +
Sbjct: 257 GL---------------------VVSGSKDS------------QQPIKFWDPKTGQSLAT 283
Query: 449 LRLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRSHGQVQRVA 508
L H V +V + G++L + A++ H L + + FR + VA
Sbjct: 284 LH---AHKNTVMEVKLNLNGNWL--LTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVA 338
Query: 509 FHPARPFLLVA--SQRSVRLYHL-LRQELTKKLMPNCKWVSSLAVHPAGDNVICGSYD 563
+HP L + S S+ +H+ + +E+ M + + SLA HP G + GS D
Sbjct: 339 WHPVHEGLFASGGSDGSLLFWHVGVEKEVGGMEMAHEGMIWSLAWHPLGHILCSGSND 396
Score = 45.4 bits (106), Expect = 2e-04
Identities = 34/120 (28%), Positives = 59/120 (49%), Gaps = 5/120 (4%)
Query: 499 RSHG-QVQRVAFHPARPFLLVAS---QRSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAG 554
R HG V+ V +HP + ++ S Q+ ++ + + L + V + ++ G
Sbjct: 241 RGHGADVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNG 300
Query: 555 DNVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYP-LFASGSDDGSVIVCH 613
+ ++ S D FD+ + ++ R HKK AVA+HP + LFASG DGS++ H
Sbjct: 301 NWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWH 360
Score = 35.4 bits (80), Expect = 0.17
Identities = 27/88 (30%), Positives = 40/88 (45%), Gaps = 23/88 (26%)
Query: 579 RMLRHHKKALRAVAFHPRYPLFASGSDDGSVIV-----CHGMVYNDLLQNPLLVPVKVLK 633
+M + HK+A+R +F P FA+ SDDG+V + CH ++L+
Sbjct: 196 KMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCH--------------EERILR 241
Query: 634 GHVLTRDLGVLDVIFHPTQPWVFSSGAD 661
GH V V +HPT+ V S D
Sbjct: 242 GH----GADVKCVDWHPTKGLVVSGSKD 265
Score = 31.2 bits (69), Expect = 3.2
Identities = 35/156 (22%), Positives = 68/156 (43%), Gaps = 6/156 (3%)
Query: 455 HGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRSHGQVQRVAFHPARP 514
HG V V WH L V + + +S + V V +
Sbjct: 243 HGADVKCVDWHPTKG-LVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNGN 301
Query: 515 FLLVASQRSV-RLYHL--LRQELTKKLMPNCKWVSSLAVHPAGDNVIC-GSYDSKLVWFD 570
+LL AS+ + +L+ + L++EL + + K +++A HP + + G D L+++
Sbjct: 302 WLLTASRDHLCKLFDIRNLKEEL-QVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWH 360
Query: 571 LDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDD 606
+ + + M H+ + ++A+HP + SGS+D
Sbjct: 361 VGVEKEVGGMEMAHEGMIWSLAWHPLGHILCSGSND 396
>gi|134133292 WD repeat domain 27 [Homo sapiens]
Length = 857
Score = 45.4 bits (106), Expect = 2e-04
Identities = 68/295 (23%), Positives = 118/295 (40%), Gaps = 38/295 (12%)
Query: 330 VYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAWNPSPA 389
V+ GH V + S +WL+S + DG+LR+W A + K + P +
Sbjct: 580 VFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSARGAELALLLG-----KDMFSKPIQS 634
Query: 390 VCLVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEASEEERQVGL 449
D+ +LL+ +G QLL + + ++ R+ + S+ + L
Sbjct: 635 AQFYYI---DAFILLS--------SGPEFQLLRYHIDTCKDEIK--RYKQKSKSK----L 677
Query: 450 RLRICHGKPVTQVTWHGRGDYLA-VVLATQGHTQVLIHQLSRRRSQSPFRRSHG------ 502
R+ V + D+ + +VLA + V + L+ S + +H
Sbjct: 678 ICRLSTTGAVDMTSLSAVNDFYSHIVLAAGRNRTVEVFDLNAGCSAAVIAEAHSRPVHQI 737
Query: 503 -QVQRVAFHPARP-----FLLVASQRSVRLYHL--LRQELTKKLMPNCKWVSSLAVHPAG 554
Q + +F +P FL A +RL+ L LR E + P + +A P G
Sbjct: 738 CQNKGSSFTTQQPQAYNLFLTTAIGDGMRLWDLRTLRCERHFEGHPTRGYPCGIAFSPCG 797
Query: 555 DNVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSV 609
CG+ D +++ ST +R L H + VAF+P P A+ + DG +
Sbjct: 798 RFAACGAEDRHAYVYEMGSSTFSHR-LAGHTDTVTGVAFNPSAPQLATATLDGKL 851
>gi|21536371 telomerase-associated protein 1 [Homo sapiens]
Length = 2627
Score = 44.7 bits (104), Expect = 3e-04
Identities = 69/270 (25%), Positives = 109/270 (40%), Gaps = 22/270 (8%)
Query: 314 LPRPRDLQPFPTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATAR---CV 370
L RP + FP L RGH V C S S G L +G D SL W+V T + +
Sbjct: 2042 LTRPHKAEDFPCGTEL--RGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLI 2099
Query: 371 RTVPV--GGVVKSVAWNPSPAVCLVAAAVEDSVLLLNPALGDRLVAGSTDQ-LLSAFVPP 427
+ P V AW L++ + + SV L +P G RL Q +SA
Sbjct: 2100 HSFPACHRDWVTGCAWTKDN--LLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAV 2157
Query: 428 EEPPLQPARWLEASEEERQ-VGLRLRICHGKPVT--------QVTWHGRGDYLAVVLATQ 478
EE + +R + Q V L H P++ + + L V +
Sbjct: 2158 EEHVVSVSRDGTLKVWDHQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLD 2217
Query: 479 GHTQVLIHQLSRRRSQSPFRRSHGQVQRVAFHPARPFLLVASQ-RSVRLYHLLRQELTKK 537
G T+ L H L ++ + S G V+ A +L AS+ SVRL+ + ++
Sbjct: 2218 GATR-LWHPLLVCQTHTLLGHS-GPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTC 2275
Query: 538 LMPNCKWVSSLAVHPAGDNVICGSYDSKLV 567
+ + V+++A P G + G+ +L+
Sbjct: 2276 IPRSSAAVTAVAWAPDGSMAVSGNQAGELI 2305
Score = 30.4 bits (67), Expect = 5.5
Identities = 17/61 (27%), Positives = 31/61 (50%), Gaps = 2/61 (3%)
Query: 335 SDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAWNPSPAVCLVA 394
S V ++ +P G VSG+ G L LW+ A+ V T G + ++ W+ + +++
Sbjct: 2280 SAAVTAVAWAPDGSMAVSGNQAGELILWQ--EAKAVATAQAPGHIGALIWSSAHTFFVLS 2337
Query: 395 A 395
A
Sbjct: 2338 A 2338
>gi|18874090 WD repeat domain 48 [Homo sapiens]
Length = 677
Score = 44.7 bits (104), Expect = 3e-04
Identities = 21/52 (40%), Positives = 32/52 (61%), Gaps = 1/52 (1%)
Query: 325 TCQALV-YRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPV 375
TC L+ +GH+D V+ L ++ G +SGS DG++RLW + RC+ T V
Sbjct: 199 TCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRV 250
>gi|14150171 THO complex 3 [Homo sapiens]
Length = 351
Score = 44.7 bits (104), Expect = 3e-04
Identities = 22/57 (38%), Positives = 32/57 (56%), Gaps = 1/57 (1%)
Query: 331 YRGHSDLVRCLSVSPGGQWL-VSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAWNP 386
YRGH D V L P L V+ S D ++R+W+V T +C+ TV G ++ W+P
Sbjct: 95 YRGHGDSVDQLCWHPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENINICWSP 151
Score = 30.8 bits (68), Expect = 4.2
Identities = 12/32 (37%), Positives = 18/32 (56%)
Query: 340 CLSVSPGGQWLVSGSDDGSLRLWEVATARCVR 371
C+ P G++ +GS D + LW+V CVR
Sbjct: 229 CIKFDPMGKYFATGSADALVSLWDVDELVCVR 260
Score = 30.4 bits (67), Expect = 5.5
Identities = 22/62 (35%), Positives = 31/62 (50%), Gaps = 2/62 (3%)
Query: 338 VRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAWNPSPAVCLVAAAV 397
VR LS S G+ L S S+D + + EV T + V +VAW+P L+A A
Sbjct: 269 VRTLSFSHDGKMLASASEDHFIDIAEVETGDKLWEVQCESPTFTVAWHPKRP--LLAFAC 326
Query: 398 ED 399
+D
Sbjct: 327 DD 328
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 43.9 bits (102), Expect = 5e-04
Identities = 33/111 (29%), Positives = 47/111 (42%), Gaps = 21/111 (18%)
Query: 330 VYRGHSD-LVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTV--PVGGVVKS----- 381
V +GH D ++ CL G +VSGSDD +L++W T +C+RT+ GGV S
Sbjct: 257 VLKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN 314
Query: 382 -----------VAWNPSPAVCLVAAAVEDSVLLLNPALGDRLVAGSTDQLL 421
WN C+ S + R+V+GS D L
Sbjct: 315 IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATL 365
Score = 37.0 bits (84), Expect = 0.059
Identities = 30/104 (28%), Positives = 45/104 (43%), Gaps = 20/104 (19%)
Query: 333 GHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARC----------VRTVPVGG--VVK 380
GH+ VRC+ + + +VSGS D +LR+W++ T +C VR V G VV
Sbjct: 341 GHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVS 398
Query: 381 SV------AWNPSPAVCLVAAAVEDSVLLLNPALGDRLVAGSTD 418
W+P CL + + G +V+GS D
Sbjct: 399 GAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLD 442
Score = 36.6 bits (83), Expect = 0.077
Identities = 22/79 (27%), Positives = 41/79 (51%), Gaps = 10/79 (12%)
Query: 334 HSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPV------GGVVKSVAWNPS 387
H V CL + ++++ SDDG+++LW++ T +R + GGVV + + +
Sbjct: 505 HQSAVTCLQFNKN--FVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNT 562
Query: 388 PAVCLVAA--AVEDSVLLL 404
VC V + E++ LL+
Sbjct: 563 KLVCAVGSRNGTEETKLLV 581
Score = 34.7 bits (78), Expect = 0.29
Identities = 17/42 (40%), Positives = 27/42 (64%), Gaps = 2/42 (4%)
Query: 332 RGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTV 373
+GH++ R S+ G +VSGS D S+R+W+V T C+ T+
Sbjct: 420 QGHTN--RVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTL 459
Score = 30.4 bits (67), Expect = 5.5
Identities = 9/24 (37%), Positives = 20/24 (83%)
Query: 350 LVSGSDDGSLRLWEVATARCVRTV 373
LVSG+ D ++++W++ T +C++T+
Sbjct: 476 LVSGNADSTVKIWDIKTGQCLQTL 499
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.434
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,016,862
Number of Sequences: 37866
Number of extensions: 1575645
Number of successful extensions: 6319
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 171
Number of HSP's successfully gapped in prelim test: 91
Number of HSP's that attempted gapping in prelim test: 4982
Number of HSP's gapped (non-prelim): 1315
length of query: 668
length of database: 18,247,518
effective HSP length: 109
effective length of query: 559
effective length of database: 14,120,124
effective search space: 7893149316
effective search space used: 7893149316
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.