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Search of human proteins with 116284376
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|116284376 histone deacetylase 2 [Homo sapiens]
(582 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|116284376 histone deacetylase 2 [Homo sapiens] 1217 0.0
gi|13128860 histone deacetylase 1 [Homo sapiens] 871 0.0
gi|13128862 histone deacetylase 3 [Homo sapiens] 549 e-156
gi|8923769 histone deacetylase 8 [Homo sapiens] 322 5e-88
gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens] 111 2e-24
gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens] 111 2e-24
gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens] 109 6e-24
gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens] 106 5e-23
gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens] 106 5e-23
gi|148539870 histone deacetylase 7 isoform d [Homo sapiens] 104 2e-22
gi|169234807 histone deacetylase 7 isoform a [Homo sapiens] 104 2e-22
gi|153085395 histone deacetylase 4 [Homo sapiens] 103 4e-22
gi|13128864 histone deacetylase 6 [Homo sapiens] 103 6e-22
gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens] 95 2e-19
gi|217272877 histone deacetylase 11 isoform 1 [Homo sapiens] 80 5e-15
gi|209862883 histone deacetylase 11 isoform 2 [Homo sapiens] 80 5e-15
gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens] 78 3e-14
gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens] 75 1e-13
gi|61097912 nucleolar protein with MIF4G domain 1 [Homo sapiens] 48 3e-05
gi|115529449 upstream binding transcription factor, RNA polymera... 46 1e-04
gi|115529451 upstream binding transcription factor, RNA polymera... 46 1e-04
gi|7657671 upstream binding transcription factor, RNA polymerase... 46 1e-04
gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1... 46 1e-04
gi|55956788 nucleolin [Homo sapiens] 44 3e-04
gi|13540523 nucleosomal binding protein 1 [Homo sapiens] 42 0.001
gi|224586804 DNA-directed DNA polymerase epsilon 3 [Homo sapiens] 42 0.002
gi|112380630 leiomodin 1 (smooth muscle) [Homo sapiens] 42 0.002
gi|168229156 NFKB activating protein [Homo sapiens] 41 0.003
gi|42560244 peptidylprolyl isomerase G [Homo sapiens] 41 0.003
gi|117553584 adaptor-related protein complex 3, delta 1 subunit ... 41 0.003
>gi|116284376 histone deacetylase 2 [Homo sapiens]
Length = 582
Score = 1217 bits (3150), Expect = 0.0
Identities = 582/582 (100%), Positives = 582/582 (100%)
Query: 1 MRSPPCGLLRWFGGPLLASWCRCHLRFRAFGTSAGWYRAFPAPPPLLPPACPSPRDYRPH 60
MRSPPCGLLRWFGGPLLASWCRCHLRFRAFGTSAGWYRAFPAPPPLLPPACPSPRDYRPH
Sbjct: 1 MRSPPCGLLRWFGGPLLASWCRCHLRFRAFGTSAGWYRAFPAPPPLLPPACPSPRDYRPH 60
Query: 61 VSLSPFLSRPSRGGSSSSSSSRRRSPVAAVAGEPMAYSQGGGKKKVCYYYDGDIGNYYYG 120
VSLSPFLSRPSRGGSSSSSSSRRRSPVAAVAGEPMAYSQGGGKKKVCYYYDGDIGNYYYG
Sbjct: 61 VSLSPFLSRPSRGGSSSSSSSRRRSPVAAVAGEPMAYSQGGGKKKVCYYYDGDIGNYYYG 120
Query: 121 QGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMS 180
QGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMS
Sbjct: 121 QGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMS 180
Query: 181 EYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKS 240
EYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKS
Sbjct: 181 EYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKS 240
Query: 241 EASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYF 300
EASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYF
Sbjct: 241 EASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYF 300
Query: 301 PGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADS 360
PGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADS
Sbjct: 301 PGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADS 360
Query: 361 LSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIP 420
LSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIP
Sbjct: 361 LSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIP 420
Query: 421 NELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIP 480
NELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIP
Sbjct: 421 NELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIP 480
Query: 481 EDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKAR 540
EDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKAR
Sbjct: 481 EDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKAR 540
Query: 541 IEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP 582
IEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
Sbjct: 541 IEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP 582
>gi|13128860 histone deacetylase 1 [Homo sapiens]
Length = 482
Score = 871 bits (2251), Expect = 0.0
Identities = 415/483 (85%), Positives = 454/483 (93%), Gaps = 5/483 (1%)
Query: 95 MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA 154
MA +QG ++KVCYYYDGD+GNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
Sbjct: 1 MAQTQGT-RRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA 59
Query: 155 TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA 214
AEEMTKYHSD+YIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
Sbjct: 60 NAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA 119
Query: 215 GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH 274
AVKLN+QQTD+AVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
Sbjct: 120 SAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH 179
Query: 275 GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ 334
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVN+P+RDGIDDESY
Sbjct: 180 GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEA 239
Query: 335 IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG 394
IFKP++SKVMEM+QPSAVVLQCG+DSLSGDRLGCFNLT+KGHAKCVE VK+FNLP+LMLG
Sbjct: 240 IFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLG 299
Query: 395 GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM 454
GGGYTIRNVARCWTYETAVALD EIPNELPYNDYFEYFGPDFKLHISPSNMTNQNT EY+
Sbjct: 300 GGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYL 359
Query: 455 EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE 514
EKIKQRLFENLRMLPHAPGVQMQAIPEDA+ E+SGDED +DPDKRISI +SDKRIAC+EE
Sbjct: 360 EKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEE 419
Query: 515 FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT 574
FSDSE+EGEGGR+N ++ KK AK+ + E++K++ ++K +V EE+K+K+ EK + KG
Sbjct: 420 FSDSEEEGEGGRKNSSNFKK-AKRVKTEDEKEKDPEEKKEVTEEEKTKE---EKPEAKGV 475
Query: 575 KSE 577
K E
Sbjct: 476 KEE 478
>gi|13128862 histone deacetylase 3 [Homo sapiens]
Length = 428
Score = 549 bits (1415), Expect = e-156
Identities = 250/425 (58%), Positives = 332/425 (78%), Gaps = 11/425 (2%)
Query: 104 KKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYH 163
K V Y+YD D+GN++YG GHPMKPHR+ +TH+L+L+YGLY+KM +++P++A+ +M ++H
Sbjct: 3 KTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFH 62
Query: 164 SDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQ 223
S++YI FL+ + P NM ++K + FNVG+DCPVF GLFEFC TG S+ GA +LN +
Sbjct: 63 SEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKI 122
Query: 224 TDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFY 283
D+A+NWAGGLHHAKK EASGFCYVNDIV+ ILELLKYH RVLYIDIDIHHGDGV+EAFY
Sbjct: 123 CDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFY 182
Query: 284 TTDRVMTVSFHKYGEY-FPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISK 342
TDRVMTVSFHKYG Y FPGTGD+ ++GA G+YY +N P+RDGIDD+SY +F+P+I++
Sbjct: 183 LTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQ 242
Query: 343 VMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRN 402
V++ YQP+ +VLQCGADSL DRLGCFNL+++GH +CVE VK+FN+PLL+LGGGGYT+RN
Sbjct: 243 VVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRN 302
Query: 403 VARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPS-NMTNQNTPEYMEKIKQRL 461
VARCWTYET++ ++ I ELPY++YFEYF PDF LH S + NQN+ +Y+++I+Q +
Sbjct: 303 VARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTI 362
Query: 462 FENLRMLPHAPGVQMQAIPEDAVHEDSGDE-DGED--PDKRISIRASDKRIACDEEFSDS 518
FENL+ML HAP VQ+ +P D + D DE D E+ P++ S R EF D
Sbjct: 363 FENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYS------RPEAPNEFYDG 416
Query: 519 EDEGE 523
+ + +
Sbjct: 417 DHDND 421
>gi|8923769 histone deacetylase 8 [Homo sapiens]
Length = 377
Score = 322 bits (826), Expect = 5e-88
Identities = 148/341 (43%), Positives = 227/341 (66%), Gaps = 2/341 (0%)
Query: 127 PHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQM 186
P R M H+L+ Y L+++M I +P A+ EEM +H+D Y++ L+ + + ++ +
Sbjct: 35 PKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSI 94
Query: 187 QRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFC 246
+ + +G DCP +G+F++ G ++ A L +A+NW+GG HHAKK EASGFC
Sbjct: 95 E-YGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFC 153
Query: 247 YVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGE-YFPGTGD 305
Y+ND VL IL L + +R+LY+D+D+HHGDGVE+AF T +VMTVS HK+ +FPGTGD
Sbjct: 154 YLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGD 213
Query: 306 LRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDR 365
+ D+G GKG+YY+VN P++DGI DE Y QI + ++ +V + + P AVVLQ GAD+++GD
Sbjct: 214 VSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDP 273
Query: 366 LGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPY 425
+ FN+T G KC++ + + L L+LGGGGY + N ARCWTY T V L + +E+P
Sbjct: 274 MCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPD 333
Query: 426 NDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLR 466
+++F +GPD+ L I+PS ++N P +++I + NL+
Sbjct: 334 HEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLK 374
>gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens]
Length = 1069
Score = 111 bits (278), Expect = 2e-24
Identities = 105/385 (27%), Positives = 169/385 (43%), Gaps = 63/385 (16%)
Query: 123 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEY 182
HP RI+ + L GL K E + KA+ EE+ HS+ + + N +
Sbjct: 657 HPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHH----SLLYGTNPLDG 712
Query: 183 SKQMQRFNVGEDCPVFDGLFEFCQLSTGG--------------------------SVAGA 216
K R +G+D F F L GG +A
Sbjct: 713 QKLDPRILLGDDSQKF-----FSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASK 767
Query: 217 VKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKY--HQRVLYIDIDIHH 274
V + AV G HHA++S A GFC+ N + + L ++L +D+D+HH
Sbjct: 768 VASGELKNGFAVVRPPG-HHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHH 826
Query: 275 GDGVEEAFYTTDRVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNFPMRDGID---- 328
G+G ++AFY ++ +S H+Y G +FPG+G ++G G G+ Y +N G+D
Sbjct: 827 GNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMG 886
Query: 329 DESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDR--LGCFNLTVK--GH-AKCVEVV 383
D Y + F+ I+ V + + P V++ G D+L G LG + +T K GH K + +
Sbjct: 887 DVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTL 946
Query: 384 KTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPS 443
+ L + GG T A C E V + + NEL E D LH SP
Sbjct: 947 ADGRVVLALEGGHDLT----AICDASEACV--NALLGNEL------EPLAEDI-LHQSP- 992
Query: 444 NMTNQNTPEYMEKIKQRLFENLRML 468
NM + + + +I+ + ++++RM+
Sbjct: 993 NMNAVISLQKIIEIQSKYWKSVRMV 1017
>gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens]
Length = 1066
Score = 111 bits (278), Expect = 2e-24
Identities = 105/385 (27%), Positives = 169/385 (43%), Gaps = 63/385 (16%)
Query: 123 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEY 182
HP RI+ + L GL K E + KA+ EE+ HS+ + + N +
Sbjct: 654 HPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHH----SLLYGTNPLDG 709
Query: 183 SKQMQRFNVGEDCPVFDGLFEFCQLSTGG--------------------------SVAGA 216
K R +G+D F F L GG +A
Sbjct: 710 QKLDPRILLGDDSQKF-----FSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASK 764
Query: 217 VKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKY--HQRVLYIDIDIHH 274
V + AV G HHA++S A GFC+ N + + L ++L +D+D+HH
Sbjct: 765 VASGELKNGFAVVRPPG-HHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHH 823
Query: 275 GDGVEEAFYTTDRVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNFPMRDGID---- 328
G+G ++AFY ++ +S H+Y G +FPG+G ++G G G+ Y +N G+D
Sbjct: 824 GNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMG 883
Query: 329 DESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDR--LGCFNLTVK--GH-AKCVEVV 383
D Y + F+ I+ V + + P V++ G D+L G LG + +T K GH K + +
Sbjct: 884 DVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTL 943
Query: 384 KTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPS 443
+ L + GG T A C E V + + NEL E D LH SP
Sbjct: 944 ADGRVVLALEGGHDLT----AICDASEACV--NALLGNEL------EPLAEDI-LHQSP- 989
Query: 444 NMTNQNTPEYMEKIKQRLFENLRML 468
NM + + + +I+ + ++++RM+
Sbjct: 990 NMNAVISLQKIIEIQSKYWKSVRMV 1014
>gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens]
Length = 1011
Score = 109 bits (273), Expect = 6e-24
Identities = 82/292 (28%), Positives = 129/292 (44%), Gaps = 48/292 (16%)
Query: 123 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEY 182
HP RI+ + L GL K E + KA+ EE+ HS+ + + N +
Sbjct: 654 HPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHH----SLLYGTNPLDG 709
Query: 183 SKQMQRFNVGEDCPVFDGLFEFCQLSTGG--------------------------SVAGA 216
K R +G+D F F L GG +A
Sbjct: 710 QKLDPRILLGDDSQKF-----FSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASK 764
Query: 217 VKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKY--HQRVLYIDIDIHH 274
V + AV G HHA++S A GFC+ N + + L ++L +D+D+HH
Sbjct: 765 VASGELKNGFAVVRPPG-HHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHH 823
Query: 275 GDGVEEAFYTTDRVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNFPMRDGID---- 328
G+G ++AFY ++ +S H+Y G +FPG+G ++G G G+ Y +N G+D
Sbjct: 824 GNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMG 883
Query: 329 DESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDR--LGCFNLTVK--GH 376
D Y + F+ I+ V + + P V++ G D+L G LG + +T K GH
Sbjct: 884 DVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGH 935
>gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens]
Length = 1123
Score = 106 bits (265), Expect = 5e-23
Identities = 82/291 (28%), Positives = 125/291 (42%), Gaps = 46/291 (15%)
Query: 123 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEY 182
HP RI+ + L GL K E R KAT +E+ HS EY L P N +
Sbjct: 705 HPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHS-EYHTLLYGTSPLNRQKL 763
Query: 183 SKQMQRFNVGEDCPVFDGLFEFCQLSTGG-SVAGAVKLNRQQTDMAVNWAGGL------- 234
+ + + + L GG V N + AV A G
Sbjct: 764 DSKKLLGPISQKM--------YAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFK 815
Query: 235 -----------------HHAKKSEASGFCYVNDIVLA--ILELLKYHQRVLYIDIDIHHG 275
HHA++S A GFC+ N + + +L+ +VL +D DIHHG
Sbjct: 816 VAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHG 875
Query: 276 DGVEEAFYTTDRVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNFPMRDGID----D 329
+G ++AFY V+ +S H+Y G +FPG+G ++G G G Y VN G+D D
Sbjct: 876 NGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGD 935
Query: 330 ESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSG--DRLGCFNLTVK--GH 376
Y F+ ++ + + P V++ G D++ G LG +++T + GH
Sbjct: 936 VEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGH 986
>gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens]
Length = 1122
Score = 106 bits (265), Expect = 5e-23
Identities = 82/291 (28%), Positives = 125/291 (42%), Gaps = 46/291 (15%)
Query: 123 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEY 182
HP RI+ + L GL K E R KAT +E+ HS EY L P N +
Sbjct: 704 HPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHS-EYHTLLYGTSPLNRQKL 762
Query: 183 SKQMQRFNVGEDCPVFDGLFEFCQLSTGG-SVAGAVKLNRQQTDMAVNWAGGL------- 234
+ + + + L GG V N + AV A G
Sbjct: 763 DSKKLLGPISQKM--------YAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFK 814
Query: 235 -----------------HHAKKSEASGFCYVNDIVLA--ILELLKYHQRVLYIDIDIHHG 275
HHA++S A GFC+ N + + +L+ +VL +D DIHHG
Sbjct: 815 VAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHG 874
Query: 276 DGVEEAFYTTDRVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNFPMRDGID----D 329
+G ++AFY V+ +S H+Y G +FPG+G ++G G G Y VN G+D D
Sbjct: 875 NGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGD 934
Query: 330 ESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSG--DRLGCFNLTVK--GH 376
Y F+ ++ + + P V++ G D++ G LG +++T + GH
Sbjct: 935 VEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGH 985
>gi|148539870 histone deacetylase 7 isoform d [Homo sapiens]
Length = 954
Score = 104 bits (260), Expect = 2e-22
Identities = 77/292 (26%), Positives = 125/292 (42%), Gaps = 54/292 (18%)
Query: 123 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKF-----LRSIRPD 177
HP RI+ + L GL + E R KA+ EE+ HS+ ++ L ++ D
Sbjct: 543 HPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLD 602
Query: 178 NMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGG-SVAGAVKLNRQQTDMAVNWAGGL-- 234
N QR F L GG V N + A WA G
Sbjct: 603 NGKLAGLLAQRM--------------FVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVT 648
Query: 235 ----------------------HHAKKSEASGFCYVNDIVLAILELLKYHQ--RVLYIDI 270
HHA S A GFC+ N + +A +L + + ++L +D
Sbjct: 649 DLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDW 708
Query: 271 DIHHGDGVEEAFYTTDRVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNFPMRDGID 328
D+HHG+G ++ FY V+ +S H++ G +FPG+G + ++GAG G+ + VN G+D
Sbjct: 709 DVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLD 768
Query: 329 ----DESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGD--RLGCFNLTVK 374
D Y F+ ++ + + P V++ G D+ G LG ++++ K
Sbjct: 769 PPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAK 820
>gi|169234807 histone deacetylase 7 isoform a [Homo sapiens]
Length = 991
Score = 104 bits (260), Expect = 2e-22
Identities = 77/292 (26%), Positives = 125/292 (42%), Gaps = 54/292 (18%)
Query: 123 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKF-----LRSIRPD 177
HP RI+ + L GL + E R KA+ EE+ HS+ ++ L ++ D
Sbjct: 580 HPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLD 639
Query: 178 NMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGG-SVAGAVKLNRQQTDMAVNWAGGL-- 234
N QR F L GG V N + A WA G
Sbjct: 640 NGKLAGLLAQRM--------------FVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVT 685
Query: 235 ----------------------HHAKKSEASGFCYVNDIVLAILELLKYHQ--RVLYIDI 270
HHA S A GFC+ N + +A +L + + ++L +D
Sbjct: 686 DLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDW 745
Query: 271 DIHHGDGVEEAFYTTDRVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNFPMRDGID 328
D+HHG+G ++ FY V+ +S H++ G +FPG+G + ++GAG G+ + VN G+D
Sbjct: 746 DVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLD 805
Query: 329 ----DESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGD--RLGCFNLTVK 374
D Y F+ ++ + + P V++ G D+ G LG ++++ K
Sbjct: 806 PPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAK 857
>gi|153085395 histone deacetylase 4 [Homo sapiens]
Length = 1084
Score = 103 bits (257), Expect = 4e-22
Identities = 84/289 (29%), Positives = 131/289 (45%), Gaps = 49/289 (16%)
Query: 123 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEY 182
HP RI+ + L GL K E R KAT EE+ HS+ + L P N +
Sbjct: 675 HPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHT-LLYGTNPLNRQKL 733
Query: 183 -SKQMQRFNVGEDCPVFDGLFEFCQLSTGG------------SVAGAVKL---------- 219
SK++ +G VF +L GG AGA +L
Sbjct: 734 DSKKL----LGSLASVF------VRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVF 783
Query: 220 ----NRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLA--ILELLKYHQRVLYIDIDIH 273
+ AV G HHA++S GFCY N + +A +L+ ++L +D D+H
Sbjct: 784 KVATGELKNGFAVVRPPG-HHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVH 842
Query: 274 HGDGVEEAFYTTDRVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNFPMRDGID--- 328
HG+G ++AFY+ V+ +S H+Y G +FPG+G ++G G G + VN G+D
Sbjct: 843 HGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPM 902
Query: 329 -DESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSG--DRLGCFNLTVK 374
D Y F+ ++ + + P V++ G D++ G LG +NL+ +
Sbjct: 903 GDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSAR 951
>gi|13128864 histone deacetylase 6 [Homo sapiens]
Length = 1215
Score = 103 bits (256), Expect = 6e-22
Identities = 88/332 (26%), Positives = 145/332 (43%), Gaps = 23/332 (6%)
Query: 86 PVAAVAGEPMAYSQGGGKKKVCYYYDGDIGNY--YYGQGHPMKPHRIRMTHNLLLNYGLY 143
PV + P+ S+ G YD ++ N+ + HP P RI L GL
Sbjct: 467 PVLPILTWPVLQSRTG------LVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLA 520
Query: 144 RKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFE 203
+ P AT E+ HS EY+ LR+ E ++ F+ CP F
Sbjct: 521 GRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICP---STFA 577
Query: 204 FCQLSTGGS--VAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAI--LELL 259
QL+TG + + AV AV G HHA++ A GFC+ N + +A + +
Sbjct: 578 CAQLATGAACRLVEAVLSGEVLNGAAVVRPPG-HHAEQDAACGFCFFNSVAVAARHAQTI 636
Query: 260 KYHQ-RVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKY--GEYFP--GTGDLRDIGAGKG 314
H R+L +D D+HHG+G + F V+ VS H+Y G +FP G IG G
Sbjct: 637 SGHALRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAG 696
Query: 315 KYYAVNFPMR-DGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTV 373
+ VN + D Y + ++ + + P V++ G D+ GD LG ++
Sbjct: 697 TGFTVNVAWNGPRMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSP 756
Query: 374 KGHAKCVEVVKTF-NLPLLMLGGGGYTIRNVA 404
+G+A ++ + ++++ GGY + +++
Sbjct: 757 EGYAHLTHLLMGLASGRIILILEGGYNLTSIS 788
Score = 92.0 bits (227), Expect = 1e-18
Identities = 81/292 (27%), Positives = 123/292 (42%), Gaps = 16/292 (5%)
Query: 124 PMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYS 183
P P R+ L+ GL + ++ A EE+ HS EYI + + + N E
Sbjct: 106 PEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELR 165
Query: 184 KQMQRFNVGEDCPVFDGLFEFCQLSTGGSV---AGAVKLNRQQTDMAVNWAGGLHHAKKS 240
+ D C GSV AV + MA+ G HHA+ S
Sbjct: 166 VLADTY----DSVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPG-HHAQHS 220
Query: 241 EASGFCYVNDIVLAILELLKYHQ--RVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKY-- 296
G+C N + +A + H+ RVL +D D+HHG G + F V+ S H+Y
Sbjct: 221 LMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQ 280
Query: 297 GEYFP--GTGDLRDIGAGKGKYYAVNFPMRD-GIDDESYGQIFKPIISKVMEMYQPSAVV 353
G ++P + G G+G+ Y +N P G+ D Y F ++ V +QP V+
Sbjct: 281 GRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVL 340
Query: 354 LQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG-GGGYTIRNVA 404
+ G D+L GD G T G A+ ++ L+L GGY +R +A
Sbjct: 341 VAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALA 392
>gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens]
Length = 669
Score = 94.7 bits (234), Expect = 2e-19
Identities = 77/304 (25%), Positives = 135/304 (44%), Gaps = 28/304 (9%)
Query: 126 KPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQ 185
+P R+ + L GL ++ +A+ EE+ HS EY+ +R + E
Sbjct: 27 RPERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQAL 86
Query: 186 MQRFNVGEDCPVFDGLFEFCQLSTGGSV--AGAVKLNRQQTDMAVNWAGGLHHAKKSEAS 243
+F+ P F +L+ G + AV Q +A+ G HH +++ A+
Sbjct: 87 SGQFDAIYFHP---STFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPG-HHGQRAAAN 142
Query: 244 GFCYVNDIVLAILELLKYH--QRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKY--GEY 299
GFC N++ +A + H R+L +D D+HHG G++ F V+ S+H+Y G +
Sbjct: 143 GFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRF 202
Query: 300 FP--GTGDLRDIGAGKGKYYAVNFPMRD-GIDDESYGQIFKPIISKVMEMYQPSAVVLQC 356
+P D +G G+G + VN P G+ + Y F ++ + + P V++
Sbjct: 203 WPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSA 262
Query: 357 GADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGG-------GGYTIRNVAR--CW 407
G DS GD G T + A ++++ ++ GG GGY + ++A C
Sbjct: 263 GFDSAIGDPEGQMQATPECFAHLTQLLQ------VLAGGRVCAVLEGGYHLESLAESVCM 316
Query: 408 TYET 411
T +T
Sbjct: 317 TVQT 320
>gi|217272877 histone deacetylase 11 isoform 1 [Homo sapiens]
Length = 347
Score = 80.1 bits (196), Expect = 5e-15
Identities = 63/201 (31%), Positives = 91/201 (45%), Gaps = 19/201 (9%)
Query: 209 TGGSV-AGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAI---LELLKYHQR 264
TGG++ AG + + R A+N GG HH GFC DI LAI E ++ R
Sbjct: 118 TGGTIMAGKLAVER---GWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISR 174
Query: 265 VLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMR 324
ID+D H G+G E F RV + + Y PG + K + +
Sbjct: 175 ATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIY-PGDRFAKQAIRRKVE-------LE 226
Query: 325 DGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVE--- 381
G +D+ Y + I K ++ + P VV G D L GDRLG +++ G K E
Sbjct: 227 WGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVF 286
Query: 382 -VVKTFNLPLLMLGGGGYTIR 401
+V+ +P+LM+ GGY R
Sbjct: 287 RMVRGRRVPILMVTSGGYQKR 307
>gi|209862883 histone deacetylase 11 isoform 2 [Homo sapiens]
Length = 296
Score = 80.1 bits (196), Expect = 5e-15
Identities = 63/201 (31%), Positives = 91/201 (45%), Gaps = 19/201 (9%)
Query: 209 TGGSV-AGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAI---LELLKYHQR 264
TGG++ AG + + R A+N GG HH GFC DI LAI E ++ R
Sbjct: 67 TGGTIMAGKLAVER---GWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISR 123
Query: 265 VLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMR 324
ID+D H G+G E F RV + + Y PG + K + +
Sbjct: 124 ATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIY-PGDRFAKQAIRRKVE-------LE 175
Query: 325 DGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVE--- 381
G +D+ Y + I K ++ + P VV G D L GDRLG +++ G K E
Sbjct: 176 WGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVF 235
Query: 382 -VVKTFNLPLLMLGGGGYTIR 401
+V+ +P+LM+ GGY R
Sbjct: 236 RMVRGRRVPILMVTSGGYQKR 256
>gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens]
Length = 649
Score = 77.8 bits (190), Expect = 3e-14
Identities = 58/220 (26%), Positives = 99/220 (45%), Gaps = 13/220 (5%)
Query: 126 KPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQ 185
+P R+ + L GL ++ +A+ EE+ HS EY+ +R + E
Sbjct: 27 RPERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQAL 86
Query: 186 MQRFNVGEDCPVFDGLFEFCQLSTGGSV--AGAVKLNRQQTDMAVNWAGGLHHAKKSEAS 243
+F+ P F +L+ G + AV Q +A+ G HH +++ A+
Sbjct: 87 SGQFDAIYFHP---STFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPG-HHGQRAAAN 142
Query: 244 GFCYVNDIVLAILELLKYH--QRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKY--GEY 299
GFC N++ +A + H R+L +D D+HHG G++ F V+ S+H+Y G +
Sbjct: 143 GFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRF 202
Query: 300 FP--GTGDLRDIGAGKGKYYAVNFPMRD-GIDDESYGQIF 336
+P D +G G+G + VN P G+ + Y F
Sbjct: 203 WPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAAF 242
>gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens]
Length = 879
Score = 75.5 bits (184), Expect = 1e-13
Identities = 58/212 (27%), Positives = 90/212 (42%), Gaps = 40/212 (18%)
Query: 123 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEY 182
HP RI+ + L GL K E + KA+ EE+ HS+ + + N +
Sbjct: 654 HPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHH----SLLYGTNPLDG 709
Query: 183 SKQMQRFNVGEDCPVFDGLFEFCQLSTGG--------------------------SVAGA 216
K R +G+D F F L GG +A
Sbjct: 710 QKLDPRILLGDDSQKF-----FSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASK 764
Query: 217 VKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKY--HQRVLYIDIDIHH 274
V + AV G HHA++S A GFC+ N + + L ++L +D+D+HH
Sbjct: 765 VASGELKNGFAVVRPPG-HHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHH 823
Query: 275 GDGVEEAFYTTDRVMTVSFHKY--GEYFPGTG 304
G+G ++AFY ++ +S H+Y G +FPG+G
Sbjct: 824 GNGTQQAFYADPSILYISLHRYDEGNFFPGSG 855
>gi|61097912 nucleolar protein with MIF4G domain 1 [Homo sapiens]
Length = 860
Score = 47.8 bits (112), Expect = 3e-05
Identities = 28/94 (29%), Positives = 47/94 (50%), Gaps = 2/94 (2%)
Query: 477 QAIPEDAVHEDSGDE--DGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKK 534
Q +PE + DS DE + E+ D +A + +++ D+E+E + A K+
Sbjct: 244 QTLPESDLESDSQDESEEEEEGDVEKEKKAQEAEAQSEDDDEDTEEEQGEEKEKGAQEKR 303
Query: 535 GAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEK 568
K+ R ED++++E+ D DKS SGEK
Sbjct: 304 RGKRVRFAEDEEKSENSSEDGDITDKSLCGSGEK 337
Score = 32.0 bits (71), Expect = 1.6
Identities = 23/84 (27%), Positives = 44/84 (52%), Gaps = 11/84 (13%)
Query: 487 DSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAK--KARIEED 544
DS E+ ED + ++ SD SDS+DE E + +K A+ +A+ E+D
Sbjct: 233 DSSGEEEEDAGQ--TLPESDLE-------SDSQDESEEEEEGDVEKEKKAQEAEAQSEDD 283
Query: 545 KKETEDKKTDVKEEDKSKDNSGEK 568
++TE+++ + KE+ + G++
Sbjct: 284 DEDTEEEQGEEKEKGAQEKRRGKR 307
>gi|115529449 upstream binding transcription factor, RNA polymerase
I isoform b [Homo sapiens]
Length = 727
Score = 45.8 bits (107), Expect = 1e-04
Identities = 32/148 (21%), Positives = 63/148 (42%), Gaps = 11/148 (7%)
Query: 436 FKLHIS--PSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDG 493
+K+H+ +++ Q+ Y E I + ++ P + + E+ +ED
Sbjct: 589 YKVHLDLWVKSLSPQDRAAYKEYISNKRKSMTKLRGPNPKSSRTTLQSKSESEEDDEEDE 648
Query: 494 EDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKT 553
+D D+ D+ DE SED G+ + D + + EED ++ +D +
Sbjct: 649 DDEDE-------DEEEEDDENGDSSEDGGDSSESSSEDESEDGDEN--EEDDEDEDDDED 699
Query: 554 DVKEEDKSKDNSGEKTDTKGTKSEQLSN 581
D ++ED + S + + G S+ SN
Sbjct: 700 DDEDEDNESEGSSSSSSSSGDSSDSDSN 727
>gi|115529451 upstream binding transcription factor, RNA polymerase
I isoform b [Homo sapiens]
Length = 727
Score = 45.8 bits (107), Expect = 1e-04
Identities = 32/148 (21%), Positives = 63/148 (42%), Gaps = 11/148 (7%)
Query: 436 FKLHIS--PSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDG 493
+K+H+ +++ Q+ Y E I + ++ P + + E+ +ED
Sbjct: 589 YKVHLDLWVKSLSPQDRAAYKEYISNKRKSMTKLRGPNPKSSRTTLQSKSESEEDDEEDE 648
Query: 494 EDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKT 553
+D D+ D+ DE SED G+ + D + + EED ++ +D +
Sbjct: 649 DDEDE-------DEEEEDDENGDSSEDGGDSSESSSEDESEDGDEN--EEDDEDEDDDED 699
Query: 554 DVKEEDKSKDNSGEKTDTKGTKSEQLSN 581
D ++ED + S + + G S+ SN
Sbjct: 700 DDEDEDNESEGSSSSSSSSGDSSDSDSN 727
>gi|7657671 upstream binding transcription factor, RNA polymerase I
isoform a [Homo sapiens]
Length = 764
Score = 45.8 bits (107), Expect = 1e-04
Identities = 32/148 (21%), Positives = 63/148 (42%), Gaps = 11/148 (7%)
Query: 436 FKLHIS--PSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDG 493
+K+H+ +++ Q+ Y E I + ++ P + + E+ +ED
Sbjct: 626 YKVHLDLWVKSLSPQDRAAYKEYISNKRKSMTKLRGPNPKSSRTTLQSKSESEEDDEEDE 685
Query: 494 EDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKT 553
+D D+ D+ DE SED G+ + D + + EED ++ +D +
Sbjct: 686 DDEDE-------DEEEEDDENGDSSEDGGDSSESSSEDESEDGDEN--EEDDEDEDDDED 736
Query: 554 DVKEEDKSKDNSGEKTDTKGTKSEQLSN 581
D ++ED + S + + G S+ SN
Sbjct: 737 DDEDEDNESEGSSSSSSSSGDSSDSDSN 764
>gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1
[Homo sapiens]
Length = 651
Score = 45.8 bits (107), Expect = 1e-04
Identities = 32/161 (19%), Positives = 71/161 (44%), Gaps = 8/161 (4%)
Query: 428 YFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHED 487
Y +Y D K + S+ + +K +++ +N++ V+ DA D
Sbjct: 280 YTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGD 339
Query: 488 SGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKE 547
S DE + + ++ DK+ +++ +S D G ++ + + KKA +DKK+
Sbjct: 340 SKDERKDTKKDKKKLKKDDKK-KDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKK 398
Query: 548 -------TEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSN 581
+ D +++++ ++ KD +K D+K + + N
Sbjct: 399 DAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKN 439
Score = 42.7 bits (99), Expect = 0.001
Identities = 28/97 (28%), Positives = 50/97 (51%), Gaps = 10/97 (10%)
Query: 486 EDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEG-GRRNVADHKKGAKKARIEED 544
E + E DK+ S + K + DEE +D++ E +G ++ D KKG K ++ ++
Sbjct: 414 ESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDK 473
Query: 545 KK------ETEDKKTDV---KEEDKSKDNSGEKTDTK 572
KK E+ + ++D+ K++ SK+ G K D K
Sbjct: 474 KKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIK 510
Score = 33.5 bits (75), Expect = 0.55
Identities = 23/70 (32%), Positives = 32/70 (45%), Gaps = 1/70 (1%)
Query: 514 EFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSK-DNSGEKTDTK 572
E+ S+DE G KKG A E K+ E+K E DK+ +S E +K
Sbjct: 114 EYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSK 173
Query: 573 GTKSEQLSNP 582
+KS +NP
Sbjct: 174 KSKSSSETNP 183
Score = 32.3 bits (72), Expect = 1.2
Identities = 22/92 (23%), Positives = 43/92 (46%), Gaps = 8/92 (8%)
Query: 486 EDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDK 545
E G +D + DK+ + + + + + +D+ + KKG+KK ++ +
Sbjct: 461 EKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKH------SKEKKGSKKDIKKDAR 514
Query: 546 KETEDKKTDVKEEDKSKDNSGEKTDTKGTKSE 577
K+TE TD + ++ SK T KG+ +E
Sbjct: 515 KDTE--STDAEFDESSKTGFKTSTKIKGSDTE 544
>gi|55956788 nucleolin [Homo sapiens]
Length = 710
Score = 44.3 bits (103), Expect = 3e-04
Identities = 36/122 (29%), Positives = 56/122 (45%), Gaps = 21/122 (17%)
Query: 466 RMLPHAPGVQMQAIP-------EDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDS 518
+ L PG + AIP ++A EDS +E+ +D ++ DEE +
Sbjct: 116 KALVATPGKKGAAIPAKGAKNGKNAKKEDSDEEEDDDSEE-------------DEEDDED 162
Query: 519 EDEGEGGRRNVADHKKGAKKARIEEDKKETE-DKKTDVKEEDKSKDNSGEKTDTKGTKSE 577
EDE E A A A +ED ++ E D+ D EED S++ + E T KG K+
Sbjct: 163 EDEDEDEIEPAAMKAAAAAPASEDEDDEDDEDDEDDDDDEEDDSEEEAMETTPAKGKKAA 222
Query: 578 QL 579
++
Sbjct: 223 KV 224
Score = 37.0 bits (84), Expect = 0.050
Identities = 32/116 (27%), Positives = 49/116 (42%), Gaps = 18/116 (15%)
Query: 481 EDAVHEDSGDEDGEDPDKRISIRASDKRIAC--------DEEFSDSED---------EGE 523
+D ED D++ ED D+ A+ K A DE+ D ED E E
Sbjct: 150 DDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDEDDEDDDDDEEDDSEEE 209
Query: 524 GGRRNVADHKKGAKKARIE-EDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQ 578
A KK AK ++ ++ E ED++ D ++ED D E D + + E+
Sbjct: 210 AMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDEDDEDDDDEDDEEEE 265
Score = 36.6 bits (83), Expect = 0.065
Identities = 28/108 (25%), Positives = 46/108 (42%), Gaps = 24/108 (22%)
Query: 478 AIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAK 537
A P +D DED ED D D+E DSE+E A KK AK
Sbjct: 180 AAPASEDEDDEDDEDDEDDD--------------DDEEDDSEEEAM--ETTPAKGKKAAK 223
Query: 538 KARI--------EEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSE 577
+ E+++++ ED+ D E+D+ D+ ++ + + + E
Sbjct: 224 VVPVKAKNVAEDEDEEEDDEDEDDDDDEDDEDDDDEDDEEEEEEEEEE 271
>gi|13540523 nucleosomal binding protein 1 [Homo sapiens]
Length = 282
Score = 42.4 bits (98), Expect = 0.001
Identities = 30/102 (29%), Positives = 52/102 (50%), Gaps = 6/102 (5%)
Query: 481 EDAVHEDSGDEDGEDPDKRISIRASDKRIACD--EEFSDSED--EGEGGRRNVADHKKGA 536
E+ +E+ G+ ED D++ + + + E+ + ED +GE G+ N D K+
Sbjct: 134 EEDQNEEKGEAGKEDKDEKGEEDGKEDKNGNEKGEDAKEKEDGKKGEDGKGNGEDGKEKG 193
Query: 537 KKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQ 578
+ + EED+KET D K + E+ K K + E D K + E+
Sbjct: 194 EDEKEEEDRKETGDGKEN--EDGKEKGDKKEGKDVKVKEDEK 233
Score = 36.2 bits (82), Expect = 0.085
Identities = 26/90 (28%), Positives = 40/90 (44%), Gaps = 12/90 (13%)
Query: 481 EDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKAR 540
ED G E+ + +K D ++ DE+ + E EGG A +K
Sbjct: 200 EDRKETGDGKENEDGKEKGDKKEGKDVKVKEDEKEREDGKEDEGGNEEEAGKEK------ 253
Query: 541 IEEDKKETEDKKTDVKEEDKSKDNSGEKTD 570
ED KE E+ KEED+ K++ G+K +
Sbjct: 254 --EDLKEEEEG----KEEDEIKEDDGKKEE 277
Score = 35.8 bits (81), Expect = 0.11
Identities = 27/103 (26%), Positives = 44/103 (42%), Gaps = 11/103 (10%)
Query: 481 EDAVHEDSGDEDGEDPDKRISIRASD---------KRIACDEEFSDSEDEGEGGRRNVAD 531
ED + +G+E GED ++ + + K DE+ + E G+ N
Sbjct: 155 EDGKEDKNGNEKGEDAKEKEDGKKGEDGKGNGEDGKEKGEDEKEEEDRKETGDGKENEDG 214
Query: 532 HKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSG--EKTDTK 572
+KG KK + KE E ++ D KE++ + EK D K
Sbjct: 215 KEKGDKKEGKDVKVKEDEKEREDGKEDEGGNEEEAGKEKEDLK 257
Score = 35.4 bits (80), Expect = 0.15
Identities = 24/98 (24%), Positives = 50/98 (51%), Gaps = 3/98 (3%)
Query: 481 EDAVHEDSGDEDGEDPDKRIS-IRASDKRIA--CDEEFSDSEDEGEGGRRNVADHKKGAK 537
++AV E+ +E+ ++ + +I+ AS+K I +E D+ ++G + VA K +
Sbjct: 68 QEAVVEEDYNENAKNGEAKITEAPASEKEIVEVKEENIEDATEKGGEKKEAVAAEVKNEE 127
Query: 538 KARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTK 575
+ + E+++ + E+K KE+ K K D G +
Sbjct: 128 EDQKEDEEDQNEEKGEAGKEDKDEKGEEDGKEDKNGNE 165
Score = 32.3 bits (72), Expect = 1.2
Identities = 25/89 (28%), Positives = 44/89 (49%), Gaps = 11/89 (12%)
Query: 486 EDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDK 545
ED+ ++ GE + + +++ ++E +E++GE G+ + K + EED
Sbjct: 106 EDATEKGGEKKEAVAAEVKNEEEDQKEDEEDQNEEKGEAGKED--------KDEKGEEDG 157
Query: 546 KETEDKKTDVKEEDKSKDNSGEK-TDTKG 573
K EDK + K ED + G+K D KG
Sbjct: 158 K--EDKNGNEKGEDAKEKEDGKKGEDGKG 184
>gi|224586804 DNA-directed DNA polymerase epsilon 3 [Homo sapiens]
Length = 147
Score = 42.0 bits (97), Expect = 0.002
Identities = 28/82 (34%), Positives = 44/82 (53%), Gaps = 3/82 (3%)
Query: 498 KRISIRASDKRIACDE-EFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVK 556
KR ++ ASD A +E EF + +KG K+A E KK+ +DKKTD +
Sbjct: 60 KRKTLNASDVLSAMEEMEFQRFVTPLKEALEAYRREQKGKKEA--SEQKKKDKDKKTDSE 117
Query: 557 EEDKSKDNSGEKTDTKGTKSEQ 578
E+DKS+D ++ + + + EQ
Sbjct: 118 EQDKSRDEDNDEDEERLEEEEQ 139
>gi|112380630 leiomodin 1 (smooth muscle) [Homo sapiens]
Length = 600
Score = 42.0 bits (97), Expect = 0.002
Identities = 28/95 (29%), Positives = 45/95 (47%), Gaps = 8/95 (8%)
Query: 486 EDSGDEDGEDPDKRISIRASDK-RIACDEEFSDSEDEGEGGRRNVADHKKGAKKARI--- 541
+++G + GE P + IR DK R+ + ++ +G G R VA K+ KK
Sbjct: 139 DEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEERAVATKKEEEKKGSDRNT 198
Query: 542 ----EEDKKETEDKKTDVKEEDKSKDNSGEKTDTK 572
++DKK E K+ KE+D+ TDT+
Sbjct: 199 GLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTR 233
Score = 35.0 bits (79), Expect = 0.19
Identities = 25/97 (25%), Positives = 48/97 (49%), Gaps = 8/97 (8%)
Query: 488 SGDEDGEDPD-KRISIRASDKRIACDEEFSDSEDEGE-----GGRRNVADHKKGAKKARI 541
S D+D + + K ++ + D+++ + +D+ EGE GG ++ + K+
Sbjct: 201 SRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAGGNTDMKKEDEKVKRGTG 260
Query: 542 EEDKKETEDK--KTDVKEEDKSKDNSGEKTDTKGTKS 576
D K+ ++K K + E ++KD+S KT K T S
Sbjct: 261 NTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPS 297
>gi|168229156 NFKB activating protein [Homo sapiens]
Length = 415
Score = 41.2 bits (95), Expect = 0.003
Identities = 29/89 (32%), Positives = 47/89 (52%), Gaps = 2/89 (2%)
Query: 494 EDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKT 553
E KR ++S ++ E SDS+ + E + D+K+ AKKA+ +E KK+ KK
Sbjct: 191 ERSKKRRKKKSSKRKHKKYSEDSDSDSDSETDSSD-EDNKRRAKKAKKKEKKKKHRSKKY 249
Query: 554 DVKEEDKSKDNSGEKTDTKGTKSEQLSNP 582
K KS+ S + + +K ++ E L NP
Sbjct: 250 KKKRSKKSRKESSD-SSSKESQEEFLENP 277
Score = 32.7 bits (73), Expect = 0.94
Identities = 20/85 (23%), Positives = 35/85 (41%), Gaps = 1/85 (1%)
Query: 495 DPDKRISIRASD-KRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKT 553
D D+ + + K+ S+ E + + R K+ KK+ + KK +ED +
Sbjct: 156 DSDEHTPVEDEEPKKSTTSASTSEEEKKKKSSRSKERSKKRRKKKSSKRKHKKYSEDSDS 215
Query: 554 DVKEEDKSKDNSGEKTDTKGTKSEQ 578
D E S D ++ K K E+
Sbjct: 216 DSDSETDSSDEDNKRRAKKAKKKEK 240
>gi|42560244 peptidylprolyl isomerase G [Homo sapiens]
Length = 754
Score = 41.2 bits (95), Expect = 0.003
Identities = 21/85 (24%), Positives = 40/85 (47%)
Query: 497 DKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVK 556
++R +R +++I S+S + + V DHK +K+ I + ++ + K VK
Sbjct: 394 NQRSPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVK 453
Query: 557 EEDKSKDNSGEKTDTKGTKSEQLSN 581
+ KSK S K +K + + N
Sbjct: 454 KRAKSKSRSKSKEKSKSKERDSKHN 478
>gi|117553584 adaptor-related protein complex 3, delta 1 subunit
isoform 1 [Homo sapiens]
Length = 1112
Score = 40.8 bits (94), Expect = 0.003
Identities = 34/103 (33%), Positives = 48/103 (46%), Gaps = 10/103 (9%)
Query: 477 QAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGA 536
+ +PE+A+ D D+D DP RA D I D+ +DSE RN K
Sbjct: 688 EEMPENALPSDEDDKDPNDP-----YRALD--IDLDKPLADSEKLPIQKHRNTETSKSPE 740
Query: 537 KKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQL 579
K + E KK + KK + K ++K +D EK K K+E L
Sbjct: 741 KDVPMVE-KKSKKPKKKEKKHKEKERDK--EKKKEKEKKAEDL 780
Score = 32.3 bits (72), Expect = 1.2
Identities = 20/66 (30%), Positives = 33/66 (50%), Gaps = 1/66 (1%)
Query: 514 EFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKG 573
E ED+ EG ++ K KK R E++++ T+ KK K+ S++ +GE
Sbjct: 811 EAQGEEDDAEGQDQDKKSPKPKKKKHRKEKEER-TKGKKKSKKQPPGSEEAAGEPVQNGA 869
Query: 574 TKSEQL 579
+ EQL
Sbjct: 870 PEEEQL 875
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.421
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,150,161
Number of Sequences: 37866
Number of extensions: 1317570
Number of successful extensions: 11122
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 131
Number of HSP's successfully gapped in prelim test: 266
Number of HSP's that attempted gapping in prelim test: 8708
Number of HSP's gapped (non-prelim): 1806
length of query: 582
length of database: 18,247,518
effective HSP length: 108
effective length of query: 474
effective length of database: 14,157,990
effective search space: 6710887260
effective search space used: 6710887260
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.