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Search of human proteins with 116235474
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|116235474 LKB1 interacting protein [Homo sapiens]
(1099 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|116235474 LKB1 interacting protein [Homo sapiens] 2219 0.0
gi|66472382 nischarin [Homo sapiens] 108 4e-23
gi|21389483 leucine-rich repeats and guanylate kinase domain con... 62 3e-09
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 60 1e-08
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 59 2e-08
gi|17975763 myelin transcription factor 1 [Homo sapiens] 59 3e-08
gi|155030232 proline, glutamic acid and leucine rich protein 1 [... 58 4e-08
gi|22749303 hypothetical protein LOC196477 [Homo sapiens] 55 4e-07
gi|194440719 chondroadherin-like [Homo sapiens] 55 5e-07
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 54 8e-07
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 54 1e-06
gi|193788651 leucine rich repeat containing 69 [Homo sapiens] 54 1e-06
gi|61742786 leucine rich repeat and death domain containing prot... 53 1e-06
gi|61742784 leucine rich repeat and death domain containing prot... 53 1e-06
gi|148229134 ring finger and KH domain containing 2 [Homo sapiens] 53 1e-06
gi|118600967 shroom family member 4 [Homo sapiens] 52 2e-06
gi|4503257 death-domain associated protein isoform a [Homo sapiens] 52 2e-06
gi|215422388 death-domain associated protein isoform a [Homo sap... 52 2e-06
gi|215422366 death-domain associated protein isoform b [Homo sap... 52 2e-06
gi|239508778 PREDICTED: hypothetical protein, partial [Homo sapi... 52 2e-06
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 52 2e-06
gi|4505101 microtubule-associated protein 7 [Homo sapiens] 52 3e-06
gi|169210053 PREDICTED: hypothetical protein [Homo sapiens] 52 4e-06
gi|61742782 leucine rich repeat and death domain containing prot... 52 4e-06
gi|118498345 AT-binding transcription factor 1 [Homo sapiens] 52 4e-06
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 52 4e-06
gi|76880480 hypothetical protein LOC9865 [Homo sapiens] 51 7e-06
gi|239745093 PREDICTED: hypothetical protein XP_002343359 [Homo ... 50 9e-06
gi|113204617 skeletal muscle ryanodine receptor isoform 2 [Homo ... 50 9e-06
gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo ... 50 9e-06
>gi|116235474 LKB1 interacting protein [Homo sapiens]
Length = 1099
Score = 2219 bits (5750), Expect = 0.0
Identities = 1099/1099 (100%), Positives = 1099/1099 (100%)
Query: 1 MFGSAPQRPVAMTTAQRDSLLWKLAGLLRESGDVVLSGCSTLSLLTPTLQQLNHVFELHL 60
MFGSAPQRPVAMTTAQRDSLLWKLAGLLRESGDVVLSGCSTLSLLTPTLQQLNHVFELHL
Sbjct: 1 MFGSAPQRPVAMTTAQRDSLLWKLAGLLRESGDVVLSGCSTLSLLTPTLQQLNHVFELHL 60
Query: 61 GPWGPGQTGFVALPSHPADSPVILQLQFLFDVLQKTLSLKLVHVAGPGPTGPIKIFPFKS 120
GPWGPGQTGFVALPSHPADSPVILQLQFLFDVLQKTLSLKLVHVAGPGPTGPIKIFPFKS
Sbjct: 61 GPWGPGQTGFVALPSHPADSPVILQLQFLFDVLQKTLSLKLVHVAGPGPTGPIKIFPFKS 120
Query: 121 LRHLELRGVPLHCLHGLRGIYSQLETLICSRSLQALEELLSACGGDFCSALPWLALLSAN 180
LRHLELRGVPLHCLHGLRGIYSQLETLICSRSLQALEELLSACGGDFCSALPWLALLSAN
Sbjct: 121 LRHLELRGVPLHCLHGLRGIYSQLETLICSRSLQALEELLSACGGDFCSALPWLALLSAN 180
Query: 181 FSYNALTALDSSLRLLSALRFLNLSHNQVQDCQGFLMDLCELHHLDISYNRLHLVPRMGP 240
FSYNALTALDSSLRLLSALRFLNLSHNQVQDCQGFLMDLCELHHLDISYNRLHLVPRMGP
Sbjct: 181 FSYNALTALDSSLRLLSALRFLNLSHNQVQDCQGFLMDLCELHHLDISYNRLHLVPRMGP 240
Query: 241 SGAALGVLILRGNELRSLHGLEQLRNLRHLDLAYNLLEGHRELSPLWLLAELRKLYLEGN 300
SGAALGVLILRGNELRSLHGLEQLRNLRHLDLAYNLLEGHRELSPLWLLAELRKLYLEGN
Sbjct: 241 SGAALGVLILRGNELRSLHGLEQLRNLRHLDLAYNLLEGHRELSPLWLLAELRKLYLEGN 300
Query: 301 PLWFHPEHRAATAQYLSPRARDAATGFLLDGKVLSLTDFQTHTSLGLSPMGPPLPWPVGS 360
PLWFHPEHRAATAQYLSPRARDAATGFLLDGKVLSLTDFQTHTSLGLSPMGPPLPWPVGS
Sbjct: 301 PLWFHPEHRAATAQYLSPRARDAATGFLLDGKVLSLTDFQTHTSLGLSPMGPPLPWPVGS 360
Query: 361 TPETSGGPDLSDSLSSGGVVTQPLLHKVKSRVRVRRASISEPSDTDPEPRTLNPSPAGWF 420
TPETSGGPDLSDSLSSGGVVTQPLLHKVKSRVRVRRASISEPSDTDPEPRTLNPSPAGWF
Sbjct: 361 TPETSGGPDLSDSLSSGGVVTQPLLHKVKSRVRVRRASISEPSDTDPEPRTLNPSPAGWF 420
Query: 421 VQQHPELELMSSFRERFGRNWLQYRSHLEPSGNPLPATPTTSAPSAPPASSQGPDTAPRP 480
VQQHPELELMSSFRERFGRNWLQYRSHLEPSGNPLPATPTTSAPSAPPASSQGPDTAPRP
Sbjct: 421 VQQHPELELMSSFRERFGRNWLQYRSHLEPSGNPLPATPTTSAPSAPPASSQGPDTAPRP 480
Query: 481 SPPQEEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQD 540
SPPQEEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQD
Sbjct: 481 SPPQEEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQD 540
Query: 541 QKEVEAELCRPLLVCPLEGPEGVRGRECFLRVTSAHLFEVELQAARTLERLELQSLEAAE 600
QKEVEAELCRPLLVCPLEGPEGVRGRECFLRVTSAHLFEVELQAARTLERLELQSLEAAE
Sbjct: 541 QKEVEAELCRPLLVCPLEGPEGVRGRECFLRVTSAHLFEVELQAARTLERLELQSLEAAE 600
Query: 601 IEPEAQAQRSPRPTGSDLLPGAPILSLRFSYICPDRQLRRYLVLEPDAHAAVQELLAVLT 660
IEPEAQAQRSPRPTGSDLLPGAPILSLRFSYICPDRQLRRYLVLEPDAHAAVQELLAVLT
Sbjct: 601 IEPEAQAQRSPRPTGSDLLPGAPILSLRFSYICPDRQLRRYLVLEPDAHAAVQELLAVLT 660
Query: 661 PVTNVAREQLGEARDLLLGRFQCLRCGHEFKPEEPRMGLDSEEGWRPLFQKTESPAVCPN 720
PVTNVAREQLGEARDLLLGRFQCLRCGHEFKPEEPRMGLDSEEGWRPLFQKTESPAVCPN
Sbjct: 661 PVTNVAREQLGEARDLLLGRFQCLRCGHEFKPEEPRMGLDSEEGWRPLFQKTESPAVCPN 720
Query: 721 CGSDHVVLLAVSRGTPNRERKQGEQSLAPSPSASPVCHPPGHGDHLDRAKNSPPQAPSTR 780
CGSDHVVLLAVSRGTPNRERKQGEQSLAPSPSASPVCHPPGHGDHLDRAKNSPPQAPSTR
Sbjct: 721 CGSDHVVLLAVSRGTPNRERKQGEQSLAPSPSASPVCHPPGHGDHLDRAKNSPPQAPSTR 780
Query: 781 DHGSWSLSPPPERCGLRSVDHRLRLFLDVEVFSDAQEEFQCCLKVPVALAGHTGEFMCLV 840
DHGSWSLSPPPERCGLRSVDHRLRLFLDVEVFSDAQEEFQCCLKVPVALAGHTGEFMCLV
Sbjct: 781 DHGSWSLSPPPERCGLRSVDHRLRLFLDVEVFSDAQEEFQCCLKVPVALAGHTGEFMCLV 840
Query: 841 VVSDRRLYLLKVTGEMREPPASWLQLTLAVPLQDLSGIELGLAGQSLRLEWAAGAGRCVL 900
VVSDRRLYLLKVTGEMREPPASWLQLTLAVPLQDLSGIELGLAGQSLRLEWAAGAGRCVL
Sbjct: 841 VVSDRRLYLLKVTGEMREPPASWLQLTLAVPLQDLSGIELGLAGQSLRLEWAAGAGRCVL 900
Query: 901 LPRDARHCRAFLEELLDVLQSLPPAWRNCVSATEEEVTPQHRLWPLLEKDSSLEARQFFY 960
LPRDARHCRAFLEELLDVLQSLPPAWRNCVSATEEEVTPQHRLWPLLEKDSSLEARQFFY
Sbjct: 901 LPRDARHCRAFLEELLDVLQSLPPAWRNCVSATEEEVTPQHRLWPLLEKDSSLEARQFFY 960
Query: 961 LRAFLVEGPSTCLVSLLLTPSTLFLLDEDAAGSPAEPSPPAASGEASEKVPPSGPGPAVR 1020
LRAFLVEGPSTCLVSLLLTPSTLFLLDEDAAGSPAEPSPPAASGEASEKVPPSGPGPAVR
Sbjct: 961 LRAFLVEGPSTCLVSLLLTPSTLFLLDEDAAGSPAEPSPPAASGEASEKVPPSGPGPAVR 1020
Query: 1021 VREQQPLSSLSSVLLYRSAPEDLRLLFYDEVSRLESFWALRVVCQEQLTALLAWIREPWE 1080
VREQQPLSSLSSVLLYRSAPEDLRLLFYDEVSRLESFWALRVVCQEQLTALLAWIREPWE
Sbjct: 1021 VREQQPLSSLSSVLLYRSAPEDLRLLFYDEVSRLESFWALRVVCQEQLTALLAWIREPWE 1080
Query: 1081 ELFSIGLRTVIQEALALDR 1099
ELFSIGLRTVIQEALALDR
Sbjct: 1081 ELFSIGLRTVIQEALALDR 1099
>gi|66472382 nischarin [Homo sapiens]
Length = 1504
Score = 108 bits (269), Expect = 4e-23
Identities = 157/614 (25%), Positives = 236/614 (38%), Gaps = 74/614 (12%)
Query: 92 VLQKTLSLKLVHVAGP-GPTG---------PIKIFPFKSLRHLELRGVPLHCLHGLRGIY 141
+L T LK + V+G GP G P + FKSL +E+ + GL
Sbjct: 180 ILDFTCRLKYLKVSGTEGPFGTSNIQEQLLPFDLSIFKSLHQVEISHCDAKHIRGLVASK 239
Query: 142 SQLETLICSRSLQALEELL--------------SACGGDFCSALP-WLALLSANFSYNAL 186
L TL S +++E+L + G + +P W AL + + S+N++
Sbjct: 240 PTLATLSVRFSATSMKEVLVPEASEFDEWEPEGTTLEGPVTAVIPTWQALTTLDLSHNSI 299
Query: 187 TALDSSLRLLSALRFLNLSHNQVQDCQGFLMDLCELHHLDISYNRLHLVPRMGPSGAALG 246
+ +D S++L+ + FL+LSHN + L L L HLD+SYN+L + + +
Sbjct: 300 SEIDESVKLIPKIEFLDLSHNGLLVVDN-LQHLYNLVHLDLSYNKLSSLEGLHTKLGNIK 358
Query: 247 VLILRGNELRSLHGLEQLRNLRHLDLAYNLLEGHRELSPLWLLAELRKLYLEGNPLWFHP 306
L L GN L SL GL +L +L +LDL N +E E+ + L L + L NPL P
Sbjct: 359 TLNLAGNLLESLSGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEHVSLLNNPLSIIP 418
Query: 307 EHRAATAQYLSPRARDAATGFLLDGKVLSLTDFQTHTSLGLSPMGPPLPWPVGSTPETSG 366
++R RA + LD V + + T L + + S PE G
Sbjct: 419 DYRTKVLAQFGERASEVC----LDDTVTTEKELDTVEVLKAIQKAKEVKSKL-SNPEKKG 473
Query: 367 GPDLSDSLS--------------SGGVVTQPLLHKVKSRVRVRRASISEPSDTDPEPRTL 412
G D S + + + QP+L A S S TD
Sbjct: 474 GEDSRLSAAPCIRPSSSPPTVAPASASLPQPILSNQGIMFVQEEALASSLSSTDSLTPEH 533
Query: 413 NPSPAGWF--VQQHPELELMSS-FRERFGRNWLQYRSHLEPSGNPLPAT----------- 458
P G ++ P + S R+ G H EP +P +
Sbjct: 534 QPIAQGCSDSLESIPAGQAASDDLRDVPGAVGGASPEHAEPEVQVVPGSGQIIFLPFTCI 593
Query: 459 --PTTSAPSAPPASSQGPDTAPRPSPPQEEARGPQESPQKMSEEVRAEPQEEEEEKEGKE 516
T+ S+ R P EA +E Q E+ E +EEEEE++ E
Sbjct: 594 GYTATNQDFIQRLSTLIRQAIERQLPAWIEAANQREEGQ--GEQGEEEDEEEEEEEDVAE 651
Query: 517 EK--EEGEMVEQGEEEAGEEEEEEQDQKEVEAELCRPLLVCPLEGPEGVRGREC-FLRVT 573
+ E G + EE G+ EEEE+++++ EAE R L L E L+V
Sbjct: 652 NRYFEMGPPDVEEEEGGGQGEEEEEEEEDEEAEEERLALEWALGADEDFLLEHIRILKVL 711
Query: 574 SAHLFEVELQAARTLERLELQSLEAAEIEPEAQAQRSPRPTGSDLLPGAPILSLRFSYIC 633
L V+ + L L A E Q R + +L SLRF +
Sbjct: 712 WCFLIHVQGSIRQFAACLVLTDFGIAVFEIPHQESRG---SSQHILS-----SLRFVFCF 763
Query: 634 PDRQLRRYLVLEPD 647
P L + L P+
Sbjct: 764 PHGDLTEFGFLMPE 777
Score = 31.6 bits (70), Expect = 4.3
Identities = 30/110 (27%), Positives = 41/110 (37%), Gaps = 11/110 (10%)
Query: 415 SPAGWFVQQHPELELMSSFRERFGRNWLQYRSHLEPSGNPLPATPTTSAPSAPPASSQGP 474
SP G F P ER N R P+ PA AP+ AS+ GP
Sbjct: 1022 SPQGSFADGQPA--------ERRASN--DQRPQEVPAEALAPAPAEVPAPAPAAASASGP 1071
Query: 475 DTAPRPSPPQEEARGPQESPQKMSEEVRAE-PQEEEEEKEGKEEKEEGEM 523
P P+ A P+E+P + AE P + E + EE ++
Sbjct: 1072 AKTPAPAEASTSALVPEETPVEAPAPPPAEAPAQYPSEHLIQATSEENQI 1121
>gi|21389483 leucine-rich repeats and guanylate kinase domain
containing [Homo sapiens]
Length = 825
Score = 62.0 bits (149), Expect = 3e-09
Identities = 74/273 (27%), Positives = 130/273 (47%), Gaps = 25/273 (9%)
Query: 49 LQQLNHVFELHLGPWGPGQTGFVALPSHPADSPVILQLQFLFD-VLQKTLSLKLVHVAGP 107
LQQL H ++ L G G S + +L L+ FD VL++ K +H G
Sbjct: 62 LQQLMHRYQ-ELDSDGDEDQGEGEAGSEESSESEMLNLEEEFDGVLREEAVAKALHHLGR 120
Query: 108 GPTGPIKIFPFKSLRHLELRGVPLHC----LHGLRGIYSQLETLICSRSLQALEELLSAC 163
+G +++ +L L V + C L L +++E L C + L EL ++
Sbjct: 121 SGSGTEQVYLNLTLSGCNLIDVSILCGYVHLQKLDLSANKIEDLSCVSCMPYLLELNASQ 180
Query: 164 GG--DFCSALPWLALLSANFSYNALTALDSSLRLLSALRFLNLSHNQVQDCQGFLMDLCE 221
F + P L A+FS+N ++ + L AL L L N++++ G +++C
Sbjct: 181 NNLTTFFNFKPPKNLKKADFSHNQISEI-CDLSAYHALTKLILDGNEIEEISG--LEMCN 237
Query: 222 -LHHLDISYNRLHLVPRMGPSGAALGVLILRGNELRSLHGLEQLRNLRHLDLAYNL---- 276
L HL ++ N++ + G + + +L L N++ + GLE L+ L++LDL++N
Sbjct: 238 NLIHLSLANNKITTIN--GLNKLPIKILCLSNNQIEMITGLEDLKALQNLDLSHNQISSL 295
Query: 277 --LEGHRELSPLWL----LAELRKL-YLEGNPL 302
LE H L + L +AELR++ Y++ P+
Sbjct: 296 QGLENHDLLEVINLEDNKIAELREIEYIKNLPI 328
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 59.7 bits (143), Expect = 1e-08
Identities = 49/134 (36%), Positives = 65/134 (48%), Gaps = 5/134 (3%)
Query: 176 LLSANFSYNALTALDSSLRLLSALRFLNLSHNQVQDCQGFLMDLCELHHLDISYNRLHLV 235
L N S+N L L + L L+ L L HN++ L L LD+S N L V
Sbjct: 130 LQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTV 189
Query: 236 PRMGPSGAALGVLILRGNELRSLHG-LEQLRNLRHLDLAYNLLEGHRELSP-LWLLAELR 293
P S ++L L L NEL+SL + +++ L+HLD NLLE + P L + L
Sbjct: 190 PASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLE---TIPPELAGMESLE 246
Query: 294 KLYLEGNPLWFHPE 307
LYL N L F PE
Sbjct: 247 LLYLRRNKLRFLPE 260
Score = 56.2 bits (134), Expect = 2e-07
Identities = 37/97 (38%), Positives = 53/97 (54%), Gaps = 1/97 (1%)
Query: 182 SYNALTALDSSLRLLSALRFLNLSHNQVQDCQGFLMDLCELHHLDISYNRLHLVPRMGPS 241
S N L +L LRLL AL L++ NQ+ + +L L L++S+N+L ++P +
Sbjct: 90 SNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITN 149
Query: 242 GAALGVLILRGNELRSL-HGLEQLRNLRHLDLAYNLL 277
L L L+ NEL + G EQL NL LDL+ N L
Sbjct: 150 LRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHL 186
Score = 47.4 bits (111), Expect = 8e-05
Identities = 36/125 (28%), Positives = 63/125 (50%), Gaps = 6/125 (4%)
Query: 180 NFSYNALTALDSSLRLLSALRFLNLSHNQVQDCQGFLMDLCELHHLDISYNRLHLVPRMG 239
+ S+N L+ + L +L L FL+L +N + + L L +++S+NR ++P +
Sbjct: 455 DLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVL 514
Query: 240 PSGAALGVLILRGNELRSL--HGLEQLRNLRHLDLAYN-LLEGHRELSPLWLLAELRKLY 296
L +++ N++ S+ ++ + NL LDL N LL+ EL LR L
Sbjct: 515 YRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGN---CVNLRTLL 571
Query: 297 LEGNP 301
L+GNP
Sbjct: 572 LDGNP 576
Score = 46.2 bits (108), Expect = 2e-04
Identities = 32/99 (32%), Positives = 49/99 (49%)
Query: 180 NFSYNALTALDSSLRLLSALRFLNLSHNQVQDCQGFLMDLCELHHLDISYNRLHLVPRMG 239
+ S N LT + +S LS+L LNLS N+++ + + L HLD + N L +P
Sbjct: 180 DLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPEL 239
Query: 240 PSGAALGVLILRGNELRSLHGLEQLRNLRHLDLAYNLLE 278
+L +L LR N+LR L L+ L + N +E
Sbjct: 240 AGMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIE 278
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 59.3 bits (142), Expect = 2e-08
Identities = 58/203 (28%), Positives = 91/203 (44%), Gaps = 19/203 (9%)
Query: 100 KLVHVAGPGPTGPIKIFPFKSLRHLELRGVPLHCLHGLRGIYSQLETLICSRSLQALEEL 159
+L V GP I ++ H + +P GI+S+ + L L +
Sbjct: 344 QLYPVGGPSQFSTIYSL---NMEHNRINKIPF-------GIFSRAKVL---SKLNMKDNQ 390
Query: 160 LSACGGDFCSALPWLALLSANFSYNALTALDSSLRLLSALRFLNLSHNQVQDCQGFLMDL 219
L++ DF + W +++ N + N LT + + L +L L LS+N ++ L +L
Sbjct: 391 LTSLPLDFGT---WTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNL 447
Query: 220 CELHHLDISYNRLHLVPRMGPSGAALGVLILRGNELRSL-HGLEQLRNLRHLDLAYNLLE 278
+L LD+ N+L +P L L+L N+L +L G+ L NL HL L NLL
Sbjct: 448 RKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLT 507
Query: 279 GHRELSPLWLLAELRKLYLEGNP 301
E + L L +LYL NP
Sbjct: 508 HLPE--EIGTLENLEELYLNDNP 528
Score = 52.4 bits (124), Expect = 2e-06
Identities = 35/104 (33%), Positives = 60/104 (57%), Gaps = 1/104 (0%)
Query: 176 LLSANFSYNALTALDSSLRLLSALRFLNLSHNQVQDCQGFLMDLCELHHLDISYNRLHLV 235
L++ S N+LT+L SL L LR L+L HN++++ + L L L + +NR+ V
Sbjct: 148 LMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTV 207
Query: 236 PRMGPSGAALGVLILRGNELRSLHG-LEQLRNLRHLDLAYNLLE 278
+ + + L +L +R N+++ L + +L NL LD+A+N LE
Sbjct: 208 EKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLE 251
Score = 49.3 bits (116), Expect = 2e-05
Identities = 39/135 (28%), Positives = 67/135 (49%), Gaps = 5/135 (3%)
Query: 175 ALLSANFSYNALTALDSSLRLLSALRFLNLSHNQVQDCQGFLMDLCELHHLDISYNRLHL 234
+L + +N +T ++ ++ LS L L++ N+++ + +LC L LD+++N+L
Sbjct: 193 SLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEH 252
Query: 235 VPRMGPSGAALGVLILRGNELRSL-HGLEQLRNLRHLDLAYNLLEG-HRELSPLWLLAEL 292
+P+ + + L L+ NEL L + L +L L L YN L R L+ L EL
Sbjct: 253 LPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEEL 312
Query: 293 RKLYLEGNPLWFHPE 307
LE N + PE
Sbjct: 313 N---LENNNISTLPE 324
Score = 34.3 bits (77), Expect = 0.67
Identities = 29/105 (27%), Positives = 52/105 (49%), Gaps = 3/105 (2%)
Query: 169 SALPWLALLSANFSY-NALTALDSSLRLLSALRFLNLSHNQVQDCQGFLMDLCELHHLDI 227
S++ L L+ + Y N L +L + + L L L LS N + L +L +L LD+
Sbjct: 117 SSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDL 176
Query: 228 SYNRLHLVPRMGPSGAALGVLILRGNELRSLHGLEQLRNLRHLDL 272
+N+L +P + +L L LR N + ++ + ++NL L +
Sbjct: 177 RHNKLREIPSVVYRLDSLTTLYLRFNRITTVE--KDIKNLSKLSM 219
>gi|17975763 myelin transcription factor 1 [Homo sapiens]
Length = 1121
Score = 58.5 bits (140), Expect = 3e-08
Identities = 32/69 (46%), Positives = 45/69 (65%), Gaps = 2/69 (2%)
Query: 485 EEARGPQESPQK--MSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQDQK 542
E+A + S QK +S E E +EEEEE+E ++E+EE E E+ EEE EEEEEE++++
Sbjct: 241 EDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEE 300
Query: 543 EVEAELCRP 551
E E E P
Sbjct: 301 EEEEEEAAP 309
Score = 53.5 bits (127), Expect = 1e-06
Identities = 29/70 (41%), Positives = 41/70 (58%)
Query: 475 DTAPRPSPPQEEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEE 534
D A S Q+ +E ++ EE E ++EEEE+E +EE+EE E E+ EEE EE
Sbjct: 242 DAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEE 301
Query: 535 EEEEQDQKEV 544
EEEE+ +V
Sbjct: 302 EEEEEAAPDV 311
Score = 46.2 bits (108), Expect = 2e-04
Identities = 25/58 (43%), Positives = 34/58 (58%)
Query: 490 PQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQDQKEVEAE 547
PQ SEE + E+E +EE+EE E E+ EEE EEEEEE++++E E E
Sbjct: 237 PQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEE 294
Score = 46.2 bits (108), Expect = 2e-04
Identities = 27/78 (34%), Positives = 41/78 (52%), Gaps = 5/78 (6%)
Query: 484 QEEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQDQKE 543
++E +E ++ EE E +EEEEE+E +EE+EE E E+ EEEA + ++D
Sbjct: 260 EDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAAPDVIFQEDTSH 319
Query: 544 VEAELCRPLLVCPLEGPE 561
A+ L GPE
Sbjct: 320 TSAQKAP-----ELRGPE 332
Score = 38.1 bits (87), Expect = 0.046
Identities = 21/63 (33%), Positives = 35/63 (55%)
Query: 485 EEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQDQKEV 544
E+A E + S+++ + E+ +E ++K E+ EEE EEEEEE+D++E
Sbjct: 219 EDAEEVVEVTTERSQDLCPQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEE 278
Query: 545 EAE 547
E E
Sbjct: 279 EEE 281
Score = 36.6 bits (83), Expect = 0.13
Identities = 21/69 (30%), Positives = 33/69 (47%)
Query: 479 RPSPPQEEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEE 538
+P +E E Q + + + EE K+ E E E+ EEE EEE+EE
Sbjct: 217 QPEDAEEVVEVTTERSQDLCPQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEE 276
Query: 539 QDQKEVEAE 547
++++E E E
Sbjct: 277 EEEEEEEEE 285
Score = 35.8 bits (81), Expect = 0.23
Identities = 27/129 (20%), Positives = 48/129 (37%), Gaps = 11/129 (8%)
Query: 445 RSHLEPSGNPLPATPTTSAPSAPPASSQGPDTAPRPSPPQEEARGPQESPQKMSEEVRAE 504
R + PS + ++P +P A S + + PQ Q+ + + +
Sbjct: 679 RENAFPSSSSCSSSPGVKSPDASQRHSSTSAPSSSMTSPQSSQASRQDEWDRPLDYTKPS 738
Query: 505 PQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQDQ-----------KEVEAELCRPLL 553
EEE +E + E ++E EE EE+ K + ++ + LL
Sbjct: 739 RLREEEPEESEPAAHSFASSEADDQEVSEENFEERKYPGEVTLTNFKLKFLSKDIKKELL 798
Query: 554 VCPLEGPEG 562
CP G +G
Sbjct: 799 TCPTPGCDG 807
Score = 33.5 bits (75), Expect = 1.1
Identities = 19/68 (27%), Positives = 35/68 (51%)
Query: 484 QEEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQDQKE 543
+EE +E ++ EE E +EEEEE+E +EE+E V E+ + ++ + +
Sbjct: 271 EEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAAPDVIFQEDTSHTSAQKAPELRG 330
Query: 544 VEAELCRP 551
E+ +P
Sbjct: 331 PESPSPKP 338
>gi|155030232 proline, glutamic acid and leucine rich protein 1
[Homo sapiens]
Length = 1130
Score = 58.2 bits (139), Expect = 4e-08
Identities = 73/261 (27%), Positives = 94/261 (36%), Gaps = 60/261 (22%)
Query: 344 SLGLSPMGPPLPWPVGSTPETSGGPDLSDS---LSSGGVVTQP--LL-----HKVKSRVR 393
S G P P+P G P GP + + LS G+V+ P LL H+ S
Sbjct: 679 SAGPMPSAGPMP-SAGPVPSARPGPPTTANHLGLSVPGLVSVPPRLLPGPENHRAGSNED 737
Query: 394 VRRASISEPSDTDPEPRTLN---PSPAGWFVQQHPELELMSSFRERFGRNWLQYRSHLEP 450
A P T P T P PA + ++ S + + L P
Sbjct: 738 PILAPSGTPPPTIPPDETFGGRVPRPAFVHYDKEEASDVEISLESDSDDSVVIVPEGLPP 797
Query: 451 SGNPLP--ATPTTSAPSAPPASSQ-------------GPDTAPRPSPPQEEARGPQESPQ 495
P P ATP AP+ PP +S P P P PP GP P
Sbjct: 798 LPPPPPSGATPPPIAPTGPPTASPPVPAKEEPEELPAAPGPLPPPPPPPPPVPGPVTLPP 857
Query: 496 KM-----------------------------SEEVRAEPQEEEEEKEGKEEKEEGEMVEQ 526
EE E +EEEEE+E EE+E+ E E+
Sbjct: 858 PQLVPEGTPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEEEEE--EEEEDFEEEEE 915
Query: 527 GEEEAGEEEEEEQDQKEVEAE 547
EEE EEEEEE+++ E E E
Sbjct: 916 DEEEYFEEEEEEEEEFEEEFE 936
Score = 50.4 bits (119), Expect = 9e-06
Identities = 27/62 (43%), Positives = 40/62 (64%)
Query: 484 QEEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQDQKE 543
+EE E ++ EE E +EEEEE E + E+EEGE+ E+ EEE EEEEE ++ ++
Sbjct: 903 EEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVED 962
Query: 544 VE 545
+E
Sbjct: 963 LE 964
Score = 33.9 bits (76), Expect = 0.87
Identities = 23/55 (41%), Positives = 32/55 (58%), Gaps = 3/55 (5%)
Query: 484 QEEARGPQESPQKMSEEV-RAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEE 537
+EE +E ++ EE E +EEEE++E +EE EE E +E G AG E EE
Sbjct: 922 EEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFG--TAGGEVEE 974
Score = 33.9 bits (76), Expect = 0.87
Identities = 32/104 (30%), Positives = 39/104 (37%), Gaps = 16/104 (15%)
Query: 452 GNPLPAT--PTTSAPSAPPASSQGPDTAPR-----PSPPQEEARGPQESPQKMSEEVRAE 504
G P P T P P +PP P+ P P EE RG +P E A
Sbjct: 975 GAPPPPTLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPE---AL 1031
Query: 505 PQEEEEEKEGKEEKEEGEMVEQGEEEAG------EEEEEEQDQK 542
P + E E+EG+ E EEE EEE E+ K
Sbjct: 1032 PSQGEVEREGESPAAGPPPQELVEEEPSAPPTLLEEETEDGSDK 1075
Score = 32.7 bits (73), Expect = 1.9
Identities = 33/103 (32%), Positives = 45/103 (43%), Gaps = 12/103 (11%)
Query: 458 TPTTSAPSAPPASSQGPDTAPRPSPPQEEARGPQESPQKMSEEVRAEPQE--EEEEKEGK 515
T T AP A P SQG SP A GP PQ++ EE + P EEE ++G
Sbjct: 1022 TAPTLAPEALP--SQGEVEREGESP----AAGP--PPQELVEEEPSAPPTLLEEETEDGS 1073
Query: 516 EEKEEGEMVEQGEEEAGEEEEEEQDQKEVE--AELCRPLLVCP 556
++ + EE E E E +KE + A + + CP
Sbjct: 1074 DKVQPPPETPAEEEMETETEAEALQEKEQDDTAAMLADFIDCP 1116
>gi|22749303 hypothetical protein LOC196477 [Homo sapiens]
Length = 406
Score = 55.1 bits (131), Expect = 4e-07
Identities = 52/163 (31%), Positives = 67/163 (41%), Gaps = 42/163 (25%)
Query: 451 SGNPLPATPTTSAPSAPPASS--------------QGPDTAPRPSPPQEEARGP---QES 493
SG PA +S APP S Q P A P+P + ++ P +E
Sbjct: 222 SGEASPAR--SSGNDAPPGGSKETWGLQETLYGFVQNPSLAFSPNPEENQSLAPLLVEEE 279
Query: 494 PQKMS------------------EEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEE 535
+K + EE E +EEE E E +EE EE E VE+GEEE EEE
Sbjct: 280 EEKKNDDEEEYDQEVCDAKEASEEEEEVEDEEEEVEDEEEEEVEEAEYVEEGEEELEEEE 339
Query: 536 EEEQDQKEVEAELCRPLLVCPLEGP-----EGVRGRECFLRVT 573
EE+++ E E PLE P E RE F+ T
Sbjct: 340 LEEEEEVLEENEQRGEEFHLPLEMPLSIFVEAEEKRENFISCT 382
>gi|194440719 chondroadherin-like [Homo sapiens]
Length = 762
Score = 54.7 bits (130), Expect = 5e-07
Identities = 64/190 (33%), Positives = 87/190 (45%), Gaps = 17/190 (8%)
Query: 120 SLRHLELRGVPLHCLH-GLRGIYSQLETLICSRSLQALEELLSACGGDFCSALPWLALLS 178
SLR LEL G L L G G L TL + + L A + WL L
Sbjct: 135 SLRRLELEGNALEELRPGTFGALGALATLNLAHNALVY---LPAMAFQGLLRVRWLRL-- 189
Query: 179 ANFSYNALTAL-DSSLRLLSALRFLNLSHNQVQDCQGFLMDLCE-LHHLDISYNRL-HLV 235
S+NAL+ L +L L ALR L+L HN++Q G ++ L L++ +N L +
Sbjct: 190 ---SHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAG 246
Query: 236 PRMGPSGAALGVLILRGNELRSL--HGLEQLRNLRHLDLAYNLLEGHRELSPLWLLAELR 293
G + L L+L G L++L L LDL N L+ L PL +LR
Sbjct: 247 EEDGLALPGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLD---TLPPLQGPGQLR 303
Query: 294 KLYLEGNPLW 303
+L L+GNPLW
Sbjct: 304 RLRLQGNPLW 313
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 53.9 bits (128), Expect = 8e-07
Identities = 31/65 (47%), Positives = 39/65 (60%), Gaps = 1/65 (1%)
Query: 484 QEEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGE-EEEEEQDQK 542
+EE G E + EE E +EEE E +G+EE EEGE E+GEE GE EEEE + +
Sbjct: 828 EEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEG 887
Query: 543 EVEAE 547
E E E
Sbjct: 888 EEEGE 892
Score = 53.1 bits (126), Expect = 1e-06
Identities = 30/64 (46%), Positives = 39/64 (60%), Gaps = 2/64 (3%)
Query: 484 QEEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQDQKE 543
+EE G +E + EE + +EE EE EG+EE EEGE +GEEE GE E EE+ + E
Sbjct: 837 EEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGE--GEGEEEEGEGEGEEEGEGE 894
Query: 544 VEAE 547
E E
Sbjct: 895 GEEE 898
Score = 52.8 bits (125), Expect = 2e-06
Identities = 28/63 (44%), Positives = 39/63 (61%)
Query: 485 EEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQDQKEV 544
EE +G +E ++ E E + EEEE EG+EE+ EG+ E+GEE GEEE EE + +
Sbjct: 820 EEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGE 879
Query: 545 EAE 547
E E
Sbjct: 880 EEE 882
Score = 49.3 bits (116), Expect = 2e-05
Identities = 30/73 (41%), Positives = 40/73 (54%), Gaps = 10/73 (13%)
Query: 485 EEARGPQESPQKMSEEVRAEPQEEEEEK----------EGKEEKEEGEMVEQGEEEAGEE 534
+E +G +E Q EE E + EE+E+ EGK E+EE E +GEEE GE
Sbjct: 783 KEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEG 842
Query: 535 EEEEQDQKEVEAE 547
EEEE + +E E E
Sbjct: 843 EEEEGEGEEEEGE 855
Score = 48.9 bits (115), Expect = 3e-05
Identities = 29/68 (42%), Positives = 39/68 (57%), Gaps = 4/68 (5%)
Query: 484 QEEARGPQESPQKMSEEVRAEPQEEEE----EKEGKEEKEEGEMVEQGEEEAGEEEEEEQ 539
+EE G +E + EE E + EEE E EG+EE+ EGE E+GE E EEE E +
Sbjct: 844 EEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGE 903
Query: 540 DQKEVEAE 547
++E E E
Sbjct: 904 GEEEGEGE 911
Score = 48.9 bits (115), Expect = 3e-05
Identities = 28/62 (45%), Positives = 38/62 (61%), Gaps = 1/62 (1%)
Query: 486 EARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQDQKEVE 545
E G +E + E+ E +EEE E EG+EE+ EGE E+GE E GEE E E +++E E
Sbjct: 929 EGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGE-GEEGEGEGEEEEGE 987
Query: 546 AE 547
E
Sbjct: 988 GE 989
Score = 48.1 bits (113), Expect = 4e-05
Identities = 27/76 (35%), Positives = 42/76 (55%), Gaps = 9/76 (11%)
Query: 479 RPSPPQEEARGPQESPQKMSEEVR---------AEPQEEEEEKEGKEEKEEGEMVEQGEE 529
R +++ RG E P + +E+ E QE++E ++G +++ EM E GEE
Sbjct: 674 REKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEE 733
Query: 530 EAGEEEEEEQDQKEVE 545
E GE EEEE D++E E
Sbjct: 734 EHGEGEEEEGDREEEE 749
Score = 48.1 bits (113), Expect = 4e-05
Identities = 34/71 (47%), Positives = 44/71 (61%), Gaps = 8/71 (11%)
Query: 484 QEEARGP-QESPQKMSEEVRAEPQEEE-----EEKEGKEE-KEEGEMVEQGEEEAGEEEE 536
+EE G +E + EE E +EEE EE+EG+EE +EEGE E+GE E GEEEE
Sbjct: 959 EEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGE-GEEEE 1017
Query: 537 EEQDQKEVEAE 547
E + + EVE E
Sbjct: 1018 EGEVEGEVEGE 1028
Score = 47.4 bits (111), Expect = 8e-05
Identities = 32/77 (41%), Positives = 40/77 (51%), Gaps = 13/77 (16%)
Query: 484 QEEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKE----------EGEMVE---QGEEE 530
+EE G E + EE E + EEEE EG+ E+E EGE E +GEEE
Sbjct: 934 EEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEE 993
Query: 531 AGEEEEEEQDQKEVEAE 547
GEEE EE+ + E E E
Sbjct: 994 EGEEEGEEEGEGEEEGE 1010
Score = 47.0 bits (110), Expect = 1e-04
Identities = 33/69 (47%), Positives = 40/69 (57%), Gaps = 9/69 (13%)
Query: 484 QEEARGPQESPQKMSEEVRAEPQEEEEEKEGK-EEKEEGEMVEQGEEEAG----EEEEEE 538
+EE G +E EE + + EEEE EG+ EEKEEG VE GE E G EEEEEE
Sbjct: 777 KEERAGKEEK----GEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEE 832
Query: 539 QDQKEVEAE 547
+ +E E E
Sbjct: 833 GEGEEEEGE 841
Score = 47.0 bits (110), Expect = 1e-04
Identities = 35/73 (47%), Positives = 43/73 (58%), Gaps = 11/73 (15%)
Query: 485 EEARGPQESPQKMSEEVRAEPQEEEEEKEGK-EEKEEGEM---VE------QGEEEAGEE 534
EE G E ++ EE E E EEE EG+ EE+EEGE+ VE +GEEE GEE
Sbjct: 982 EEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEE 1041
Query: 535 EEEEQDQKEVEAE 547
E EE+ +KE E E
Sbjct: 1042 EGEER-EKEGEGE 1053
Score = 45.8 bits (107), Expect = 2e-04
Identities = 26/64 (40%), Positives = 37/64 (57%)
Query: 484 QEEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQDQKE 543
QE G +E + EE +EEE+E EGKEE E E+ + E+E GE ++EE+ KE
Sbjct: 725 QEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKE 784
Query: 544 VEAE 547
+ E
Sbjct: 785 EKGE 788
Score = 45.8 bits (107), Expect = 2e-04
Identities = 26/62 (41%), Positives = 35/62 (56%)
Query: 486 EARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQDQKEVE 545
E G +E + EE EEE E EG+EE+ EG+ E+GEE GE EEEE + + +
Sbjct: 884 EGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGED 943
Query: 546 AE 547
E
Sbjct: 944 GE 945
Score = 45.4 bits (106), Expect = 3e-04
Identities = 27/70 (38%), Positives = 40/70 (57%), Gaps = 6/70 (8%)
Query: 484 QEEARGPQESPQKMSEEVRAEPQEEE---EEKEGKEEKEEGEMVEQ---GEEEAGEEEEE 537
+E G +E + EE + +EE EE EG+ EKEEGE ++ G+EE GEEE +
Sbjct: 733 EEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGD 792
Query: 538 EQDQKEVEAE 547
+ + +E E E
Sbjct: 793 QGEGEEEETE 802
Score = 45.1 bits (105), Expect = 4e-04
Identities = 29/77 (37%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 472 QGPDTAPRPSPPQEEARGPQESPQKMSEEVRAEPQEEEEEKEGK-EEKEEGEMVEQGEEE 530
+G + + E +G +E + EE E + E EE+EG+ E +EEGE +GEEE
Sbjct: 841 EGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGE--GEGEEE 898
Query: 531 AGEEEEEEQDQKEVEAE 547
GE E EE+ + E E E
Sbjct: 899 EGEGEGEEEGEGEGEEE 915
Score = 44.3 bits (103), Expect = 6e-04
Identities = 29/62 (46%), Positives = 37/62 (59%), Gaps = 4/62 (6%)
Query: 489 GPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGE---EEAGEEEEEEQDQKEVE 545
G E + EE E + EEEE EG+EE+ EGE E+GE EE GEE E E++ +E E
Sbjct: 817 GEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGE-EEEGEGKGEEEGEEGEGEEEGEEGE 875
Query: 546 AE 547
E
Sbjct: 876 GE 877
Score = 44.3 bits (103), Expect = 6e-04
Identities = 27/64 (42%), Positives = 36/64 (56%), Gaps = 3/64 (4%)
Query: 485 EEARGPQESPQKMSEEVRAEPQ---EEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQDQ 541
EE G +E + E E + EEE E EG+EE+ EGE E+GE E EEE E + +
Sbjct: 863 EEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGE 922
Query: 542 KEVE 545
+E E
Sbjct: 923 EEGE 926
Score = 44.3 bits (103), Expect = 6e-04
Identities = 28/65 (43%), Positives = 37/65 (56%), Gaps = 5/65 (7%)
Query: 486 EARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGE---EEEEEQDQK 542
E G +E + EE E + E EE+EG+ E E+GE +GEEE GE EEEE + +
Sbjct: 909 EGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGE--GEGEEEEGEWEGEEEEGEGEG 966
Query: 543 EVEAE 547
E E E
Sbjct: 967 EEEGE 971
Score = 44.3 bits (103), Expect = 6e-04
Identities = 37/93 (39%), Positives = 45/93 (48%), Gaps = 21/93 (22%)
Query: 486 EARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKE-EGEMVEQGEEEA----------GEE 534
E G +E + EE E +E EEE EG+EE E EGE E+GE E GEE
Sbjct: 978 EGEGEEEEGEGEGEEEEGE-EEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEE 1036
Query: 535 EEEEQDQKEVEAELCRPLLVCPLEGPEGVRGRE 567
EE E++ +E E E EG E R RE
Sbjct: 1037 EEGEEEGEEREKE---------GEGEENRRNRE 1060
Score = 44.3 bits (103), Expect = 6e-04
Identities = 26/66 (39%), Positives = 38/66 (57%), Gaps = 2/66 (3%)
Query: 484 QEEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGE--EEAGEEEEEEQDQ 541
+EE G +E + EE E + E E +EG+ E EE E E+GE E+ GE EE +++
Sbjct: 1000 EEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNR 1059
Query: 542 KEVEAE 547
+E E E
Sbjct: 1060 EEEEEE 1065
Score = 43.9 bits (102), Expect = 8e-04
Identities = 25/60 (41%), Positives = 35/60 (58%), Gaps = 2/60 (3%)
Query: 486 EARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQDQKEVE 545
E +G +E + E E + E E+ EG+ E+EEGE +GEEE GE E EE+ + E E
Sbjct: 918 EGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEW--EGEEEEGEGEGEEEGEGEGE 975
Score = 43.9 bits (102), Expect = 8e-04
Identities = 36/101 (35%), Positives = 48/101 (47%), Gaps = 20/101 (19%)
Query: 472 QGPDTAPRPSPPQEEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGE-MVEQGEEE 530
+G D + E G +E + EE E + EE E EG+EE+ EGE E+GEEE
Sbjct: 940 EGEDGEGEGEEEEGEWEGEEEEGEGEGEE-EGEGEGEEGEGEGEEEEGEGEGEEEEGEEE 998
Query: 531 A---------GEEEEEEQDQKEVEAELCRPLLVCPLEGPEG 562
GE E EE+++ EVE E +EG EG
Sbjct: 999 GEEEGEGEEEGEGEGEEEEEGEVEGE---------VEGEEG 1030
Score = 43.5 bits (101), Expect = 0.001
Identities = 34/91 (37%), Positives = 46/91 (50%), Gaps = 19/91 (20%)
Query: 472 QGPDTAPRPSPPQEEARGPQESPQKMSE-------EVRAEPQEEEEEKEGKE-----EKE 519
+G + + +EE G E ++ E E + E +EEEEE EG+E E+E
Sbjct: 786 KGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEE 845
Query: 520 EGEMVEQGEEEAGE---EEEEEQDQKEVEAE 547
EGE GEEE GE EEE E+ + E E E
Sbjct: 846 EGE----GEEEEGEGKGEEEGEEGEGEEEGE 872
Score = 43.5 bits (101), Expect = 0.001
Identities = 27/67 (40%), Positives = 37/67 (55%), Gaps = 3/67 (4%)
Query: 484 QEEARGPQESPQ---KMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQD 540
+EE G E + + EE E +EEE E +G+EE EEGE + EE GE E+ E +
Sbjct: 888 EEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGE 947
Query: 541 QKEVEAE 547
+E E E
Sbjct: 948 GEEEEGE 954
Score = 43.1 bits (100), Expect = 0.001
Identities = 27/64 (42%), Positives = 35/64 (54%), Gaps = 5/64 (7%)
Query: 484 QEEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQDQKE 543
+EE G E EE + +EE EE EG+ E+EEGE + E GEEEE E + +E
Sbjct: 905 EEEGEGEGEE-----EEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEE 959
Query: 544 VEAE 547
E E
Sbjct: 960 EEGE 963
Score = 42.4 bits (98), Expect = 0.002
Identities = 32/70 (45%), Positives = 38/70 (54%), Gaps = 9/70 (12%)
Query: 485 EEARGPQESPQKMSEEVRAEPQEEEEEKEGKE-----EKEEGEMVEQGEEEAGEEE--EE 537
EE G E + EE + E +EE EG+E EKEEGE + EE AG+EE EE
Sbjct: 732 EEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGE--RKKEERAGKEEKGEE 789
Query: 538 EQDQKEVEAE 547
E DQ E E E
Sbjct: 790 EGDQGEGEEE 799
Score = 42.4 bits (98), Expect = 0.002
Identities = 26/64 (40%), Positives = 35/64 (54%), Gaps = 1/64 (1%)
Query: 484 QEEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQDQKE 543
+EE G E + EE E +EEE E+EG+E ++EGE E EEEEE + Q+
Sbjct: 1014 EEEEEGEVEGEVE-GEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQET 1072
Query: 544 VEAE 547
E E
Sbjct: 1073 GEEE 1076
Score = 42.0 bits (97), Expect = 0.003
Identities = 29/75 (38%), Positives = 36/75 (48%), Gaps = 17/75 (22%)
Query: 486 EARGPQESPQKMSEEVRAEPQEEE-EEKEGKEEKEEGEMVEQGEE--------------- 529
E G +E ++ EV E E E EE+EG+EE EE E +GEE
Sbjct: 1010 EGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKY 1069
Query: 530 -EAGEEEEEEQDQKE 543
E GEEE E QD +E
Sbjct: 1070 QETGEEENERQDGEE 1084
Score = 41.2 bits (95), Expect = 0.005
Identities = 25/67 (37%), Positives = 37/67 (55%), Gaps = 5/67 (7%)
Query: 484 QEEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKE-----EGEMVEQGEEEAGEEEEEE 538
+E +G Q+ + EE E E EE+EG E+E EG+ +GEE GE E+EE
Sbjct: 713 KEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEE 772
Query: 539 QDQKEVE 545
++K+ E
Sbjct: 773 GERKKEE 779
Score = 41.2 bits (95), Expect = 0.005
Identities = 29/74 (39%), Positives = 39/74 (52%), Gaps = 10/74 (13%)
Query: 479 RPSPPQEEARGPQESPQKMSEEVRAEPQEEE-----EEKEGKEEK--EEGEMVEQGEEEA 531
R ++E G +E EEV E ++EE EE+ GKEEK EEG+ E EEE
Sbjct: 745 REEEEEKEGEGKEEGE---GEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEET 801
Query: 532 GEEEEEEQDQKEVE 545
EE+++ EVE
Sbjct: 802 EGRGEEKEEGGEVE 815
Score = 40.8 bits (94), Expect = 0.007
Identities = 28/65 (43%), Positives = 38/65 (58%), Gaps = 7/65 (10%)
Query: 485 EEARGPQESPQKMSEEVRAEPQEEEEEK---EGKEEKEEGE---MVEQGEEEAGEEEEEE 538
EE G +E ++ E E + EEEE+ EG+ E EEGE E+GEEE GEE E+E
Sbjct: 991 EEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEE-GEEREKE 1049
Query: 539 QDQKE 543
+ +E
Sbjct: 1050 GEGEE 1054
Score = 40.0 bits (92), Expect = 0.012
Identities = 24/73 (32%), Positives = 36/73 (49%), Gaps = 3/73 (4%)
Query: 472 QGPDTAPRPSPPQEEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVE---QGE 528
+G + +EE G E ++ E E +E E E E +E +EEGE E +GE
Sbjct: 994 EGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGE 1053
Query: 529 EEAGEEEEEEQDQ 541
E EEEE+++
Sbjct: 1054 ENRRNREEEEEEE 1066
Score = 39.7 bits (91), Expect = 0.016
Identities = 25/67 (37%), Positives = 35/67 (52%), Gaps = 4/67 (5%)
Query: 485 EEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEE----GEMVEQGEEEAGEEEEEEQD 540
E R +E +K E E + EEE +G+ E+EE GE E+G E G E EE +
Sbjct: 765 EGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKG 824
Query: 541 QKEVEAE 547
++E E E
Sbjct: 825 EREEEEE 831
Score = 39.3 bits (90), Expect = 0.021
Identities = 25/64 (39%), Positives = 37/64 (57%), Gaps = 5/64 (7%)
Query: 488 RGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEE----EEQDQKE 543
R +E QK E+ + + +E E+ G+EE EGE E+G+ E EE+E EE + +E
Sbjct: 705 RDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGE-EEEGDREEEEEKEGEGKEEGEGEE 763
Query: 544 VEAE 547
VE E
Sbjct: 764 VEGE 767
Score = 38.9 bits (89), Expect = 0.027
Identities = 22/62 (35%), Positives = 35/62 (56%)
Query: 486 EARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQDQKEVE 545
E + +E Q +E E +E EE+ G+ E+EEG+ E+ E+E +EE E ++ E E
Sbjct: 708 EEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGE 767
Query: 546 AE 547
E
Sbjct: 768 RE 769
Score = 37.7 bits (86), Expect = 0.060
Identities = 22/51 (43%), Positives = 33/51 (64%), Gaps = 8/51 (15%)
Query: 503 AEPQEEEEEKEGKEEKEEGEMVE--QGEEEAGEEEE------EEQDQKEVE 545
AE ++EE ++G+++K GEM +GE+E E+EE EEQ+QKE E
Sbjct: 666 AEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKERE 716
Score = 35.4 bits (80), Expect = 0.30
Identities = 24/62 (38%), Positives = 32/62 (51%), Gaps = 4/62 (6%)
Query: 484 QEEARGPQESPQKMSEEVRAEPQEEEEEKEGKEE--KEEGEMVEQGEEEAGEEEEEEQDQ 541
Q+E R E + E R P E E+E KEE K +GE EQ E E G ++E Q+
Sbjct: 670 QDEEREKGEKDKGRGEMER--PGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEM 727
Query: 542 KE 543
+E
Sbjct: 728 EE 729
Score = 33.1 bits (74), Expect = 1.5
Identities = 22/53 (41%), Positives = 30/53 (56%), Gaps = 6/53 (11%)
Query: 485 EEARGPQESPQKMSE---EVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEE 534
EE G +E ++ E E +EEEEE+EGK + E GE E+ E + GEE
Sbjct: 1035 EEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQ-ETGE--EENERQDGEE 1084
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 53.5 bits (127), Expect = 1e-06
Identities = 51/145 (35%), Positives = 65/145 (44%), Gaps = 26/145 (17%)
Query: 182 SYNALTALDSSLRLLSALRFLNLSHNQVQDCQGFLMDLCELHHLDISYNRLHLVPR---- 237
S+N L L SL LS LR L++ HNQ+ L+ L L LD+S NRL +P
Sbjct: 166 SFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISA 225
Query: 238 ------MGPSGAALGVLILRGNELRSLHGL--------------EQLRNLRHLDLAYNLL 277
+ SGA LG L EL SL L L+ L+ L+L+ NL
Sbjct: 226 LRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLF 285
Query: 278 EGHRELSPLWLLAELRKLYLEGNPL 302
E + L LA L +LYL N L
Sbjct: 286 EEFP--AALLPLAGLEELYLSRNQL 308
Score = 48.9 bits (115), Expect = 3e-05
Identities = 52/147 (35%), Positives = 69/147 (46%), Gaps = 11/147 (7%)
Query: 160 LSACGGDFCSALPWLALLSANFSYNALTALDSSLRLLSALRFLNLSHNQVQDCQGFLMDL 219
L+A G + SAL L L N S+N L AL + L L+ L L++S N++ L L
Sbjct: 123 LTALGAEVVSALRELRKL--NLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCL 180
Query: 220 CELHHLDISYNRLHLVPRMGPSGAALGVLILRGNELRSLHGLEQLRNLRHLDLAYNLLEG 279
L LD+ +N+L PR AL L + N LR L E + LR L + + L G
Sbjct: 181 SRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLP--EDISALRALKILW--LSG 236
Query: 280 HRELSPL----WLLAELRKLYLEGNPL 302
EL L LA L L L+ N L
Sbjct: 237 -AELGTLPAGFCELASLESLMLDNNGL 262
Score = 42.7 bits (99), Expect = 0.002
Identities = 40/135 (29%), Positives = 55/135 (40%), Gaps = 10/135 (7%)
Query: 137 LRGIYSQLETLICSRSLQALEELLSACGGDFCSALPWLALLSANFSYNALTALDSSLRLL 196
LRG+ + L + L L FC +L+ N N L AL + L
Sbjct: 216 LRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDN---NGLQALPAQFSCL 272
Query: 197 SALRFLNLSHNQVQDCQGFLMDLCELHHLDISYNRLHLVPRMGPSGAALGVLILRGNELR 256
L+ LNLS N ++ L+ L L L +S N+L VP + L L L N +R
Sbjct: 273 QRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIR 332
Query: 257 -------SLHGLEQL 264
L GLE+L
Sbjct: 333 YLPDSIVELTGLEEL 347
>gi|193788651 leucine rich repeat containing 69 [Homo sapiens]
Length = 347
Score = 53.5 bits (127), Expect = 1e-06
Identities = 45/141 (31%), Positives = 71/141 (50%), Gaps = 14/141 (9%)
Query: 168 CSALPWLALLSANFSYNALTALDSSLRLLSALRFLNLSHNQVQDCQGFLMDLCELHHLDI 227
C L L LL N + N LT L + L +L ++++++NQ+ L L L L +
Sbjct: 103 CDGLQNLILL--NLNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQL 160
Query: 228 SYNRLHLVPRMGPSGAALGVLILRGNELRSL-HGLEQLRNLRHLDLAYNLLE----GHRE 282
+YN+L +P L L+L N + L L L+ LR LD+A N+++ G ++
Sbjct: 161 NYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQD 220
Query: 283 LSPLWLLAELRKLYLEGNPLW 303
L +LR+ Y EGNPL+
Sbjct: 221 L-------KLREFYCEGNPLF 234
Score = 32.0 bits (71), Expect = 3.3
Identities = 32/104 (30%), Positives = 50/104 (48%), Gaps = 3/104 (2%)
Query: 196 LSALRFLNLSHNQVQDCQGFLMDLCELHHLDISYNRL-HLVPRMGPSGAALGVLILRGNE 254
L+ L LNL +N +++ + L L +L +S NR+ P L +L L N
Sbjct: 59 LTQLTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNH 118
Query: 255 LRSL-HGLEQLRNLRHLDLAYNLLEG-HRELSPLWLLAELRKLY 296
L L + +L++L ++ + YN L REL L L EL+ Y
Sbjct: 119 LTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNY 162
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 53.1 bits (126), Expect = 1e-06
Identities = 61/170 (35%), Positives = 79/170 (46%), Gaps = 14/170 (8%)
Query: 126 LRGVPLHCLHGLRGIYSQLETLICSRSLQALEELLSACGGDFCSALPWLALLSANFSYNA 185
LRG + GL G+ + SL E L AC L L + S+N
Sbjct: 110 LRGALTNLPAGLSGLAHLAHLDLSFNSL----ETLPAC------VLQMRGLGALLLSHNC 159
Query: 186 LTALDSSLRLLSALRFLNLSHNQVQDCQGFLMDLCELHHLDISYNRLH-LVPRMGPSGAA 244
L+ L +L L AL FL ++HN++Q L L L LD+S N L L P +G G+
Sbjct: 160 LSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSL 219
Query: 245 LGVLILRGNELRSL-HGLEQLRNLRHLDLAYNLLEG-HRELSPLWLLAEL 292
L L L N L+SL L LR+LR L L NLL +L+ L LL L
Sbjct: 220 L-ELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRL 268
Score = 33.5 bits (75), Expect = 1.1
Identities = 38/130 (29%), Positives = 56/130 (43%), Gaps = 14/130 (10%)
Query: 107 PGPTGPIKIFPFKSLRHLELRGVPLHCLHGLRGIYSQLETLICSRSLQALEELLSACGGD 166
P G + F ++ H L+ +P G S L+ L S++L L+ L GG
Sbjct: 164 PEALGALPALTFLTVTHNRLQTLP-----PALGALSTLQRLDLSQNL--LDTLPPEIGG- 215
Query: 167 FCSALPWLALLSANFSYNALTALDSSLRLLSALRFLNLSHNQVQDCQGFLMDLCELHHLD 226
+LL N + N L +L +SL L +LR L L N + L L L LD
Sbjct: 216 ------LGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLD 269
Query: 227 ISYNRLHLVP 236
+ N+L +P
Sbjct: 270 LRDNQLRDLP 279
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 53.1 bits (126), Expect = 1e-06
Identities = 61/170 (35%), Positives = 79/170 (46%), Gaps = 14/170 (8%)
Query: 126 LRGVPLHCLHGLRGIYSQLETLICSRSLQALEELLSACGGDFCSALPWLALLSANFSYNA 185
LRG + GL G+ + SL E L AC L L + S+N
Sbjct: 110 LRGALTNLPAGLSGLAHLAHLDLSFNSL----ETLPAC------VLQMRGLGALLLSHNC 159
Query: 186 LTALDSSLRLLSALRFLNLSHNQVQDCQGFLMDLCELHHLDISYNRLH-LVPRMGPSGAA 244
L+ L +L L AL FL ++HN++Q L L L LD+S N L L P +G G+
Sbjct: 160 LSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSL 219
Query: 245 LGVLILRGNELRSL-HGLEQLRNLRHLDLAYNLLEG-HRELSPLWLLAEL 292
L L L N L+SL L LR+LR L L NLL +L+ L LL L
Sbjct: 220 L-ELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRL 268
Score = 33.5 bits (75), Expect = 1.1
Identities = 38/130 (29%), Positives = 56/130 (43%), Gaps = 14/130 (10%)
Query: 107 PGPTGPIKIFPFKSLRHLELRGVPLHCLHGLRGIYSQLETLICSRSLQALEELLSACGGD 166
P G + F ++ H L+ +P G S L+ L S++L L+ L GG
Sbjct: 164 PEALGALPALTFLTVTHNRLQTLP-----PALGALSTLQRLDLSQNL--LDTLPPEIGG- 215
Query: 167 FCSALPWLALLSANFSYNALTALDSSLRLLSALRFLNLSHNQVQDCQGFLMDLCELHHLD 226
+LL N + N L +L +SL L +LR L L N + L L L LD
Sbjct: 216 ------LGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLD 269
Query: 227 ISYNRLHLVP 236
+ N+L +P
Sbjct: 270 LRDNQLRDLP 279
>gi|148229134 ring finger and KH domain containing 2 [Homo sapiens]
Length = 659
Score = 53.1 bits (126), Expect = 1e-06
Identities = 44/142 (30%), Positives = 64/142 (45%), Gaps = 22/142 (15%)
Query: 397 ASISEPSDTDPEPRTLNPSPAGWFVQQHPELELMSSFRERFGRNWLQYRSHLEPSG--NP 454
A + +P P P P P+G PELE + L R L G +P
Sbjct: 16 APLPQPPPPPPPPPPPLPPPSGG-----PELE----------GDGLLLRERLAALGLDDP 60
Query: 455 LPATPTTSAPSAPPASSQGPDTAPRPSPPQEEARGPQESPQKMSEEVRAEPQEEEEEKEG 514
PA P A AP A++QG P+E A P + AE + EE+E+EG
Sbjct: 61 SPAEPGAPALRAPAAAAQGQARRAAELSPEERA-----PPGRPGAPEAAELELEEDEEEG 115
Query: 515 KEEKEEGEMVEQGEEEAGEEEE 536
+E + +G+++E+ E E EEE+
Sbjct: 116 EEAELDGDLLEEEELEEAEEED 137
>gi|118600967 shroom family member 4 [Homo sapiens]
Length = 1493
Score = 52.4 bits (124), Expect = 2e-06
Identities = 35/100 (35%), Positives = 50/100 (50%), Gaps = 12/100 (12%)
Query: 439 RNWLQYRSHLEPSGNPLPATPTTSAPSAPPASSQGPDTAPRPSPPQEEARGPQESPQKMS 498
R W Q+R L G+ + + A P PRP PP E + Q+
Sbjct: 1071 RAWGQHRRELFSKGDETQSDLLGARKKAFPP--------PRPPPPNWEKYRLFRAAQQQK 1122
Query: 499 EEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEE 538
++ + + Q+EEEE+E +EE+EE E+ EEE EEEEEE
Sbjct: 1123 QQQQQQKQQEEEEEEEEEEEEE----EEEEEEEAEEEEEE 1158
>gi|4503257 death-domain associated protein isoform a [Homo sapiens]
Length = 740
Score = 52.4 bits (124), Expect = 2e-06
Identities = 28/81 (34%), Positives = 43/81 (53%), Gaps = 1/81 (1%)
Query: 460 TTSAPSAPPASSQGPD-TAPRPSPPQEEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEK 518
+ P A S +GP A + P A E ++ EE E +EEEEE EE+
Sbjct: 405 SADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEE 464
Query: 519 EEGEMVEQGEEEAGEEEEEEQ 539
E+ E +++G+E+ EE+EEE+
Sbjct: 465 EDLEQMQEGQEDDEEEDEEEE 485
Score = 48.5 bits (114), Expect = 3e-05
Identities = 43/153 (28%), Positives = 71/153 (46%), Gaps = 21/153 (13%)
Query: 401 EPSDTDP-------EPRTLNPSPAGWFVQQHPELELMSSFRERFGRNWLQYRSHLEPSGN 453
+P+ +DP E R+L S + ++ L+ S ER R R+ L+ + +
Sbjct: 349 DPALSDPVLARRLRENRSLAMSRLDEVISKYAMLQDKSEEGERKKR-----RARLQGTSS 403
Query: 454 PLPATPTTSAPSAPPASSQGPDTAPRPSPPQEEARGPQESPQKMSEEVRAEPQEEEEEKE 513
TP S S S P S + + +ES ++ E +EEEEE+E
Sbjct: 404 HSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEE-------EEEEEEEEEE 456
Query: 514 GKEEKEEGEMVEQGEEEAGEEEEEEQDQKEVEA 546
+ EE E +EQ +E G+E++EE+D++E A
Sbjct: 457 EATDSEEEEDLEQMQE--GQEDDEEEDEEEEAA 487
Score = 32.7 bits (73), Expect = 1.9
Identities = 44/201 (21%), Positives = 78/201 (38%), Gaps = 31/201 (15%)
Query: 451 SGNPLPATPTTSAPSAPPASSQGPDTAPRPSPPQEEARGPQESPQKMSEEVRAEPQEEEE 510
SG + PSA A + D +EE +E EE E +E +
Sbjct: 415 SGEGPSGMASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQ 474
Query: 511 EKEGKE-EKEEGEMVEQGEE--------------EAGEEEEEEQDQKEVEAELCRPLLVC 555
E + +E E+EE + G++ E G++ +++ + + P L+
Sbjct: 475 EDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLS 534
Query: 556 --PL------EGPEGVRGRECFLRVTS--AHLFEVELQAARTLERLELQSLEAAEIEPEA 605
PL G + E L S + LFE+E++A L L + + E + +
Sbjct: 535 EEPLAPSSIDAESNGEQPEELTLEEESPVSQLFELEIEA------LPLDTPSSVETDISS 588
Query: 606 QAQRSPRPTGSDLLPGAPILS 626
++S P + L GA ++S
Sbjct: 589 SRKQSEEPFTTVLENGAGMVS 609
>gi|215422388 death-domain associated protein isoform a [Homo
sapiens]
Length = 740
Score = 52.4 bits (124), Expect = 2e-06
Identities = 28/81 (34%), Positives = 43/81 (53%), Gaps = 1/81 (1%)
Query: 460 TTSAPSAPPASSQGPD-TAPRPSPPQEEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEK 518
+ P A S +GP A + P A E ++ EE E +EEEEE EE+
Sbjct: 405 SADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEE 464
Query: 519 EEGEMVEQGEEEAGEEEEEEQ 539
E+ E +++G+E+ EE+EEE+
Sbjct: 465 EDLEQMQEGQEDDEEEDEEEE 485
Score = 48.5 bits (114), Expect = 3e-05
Identities = 43/153 (28%), Positives = 71/153 (46%), Gaps = 21/153 (13%)
Query: 401 EPSDTDP-------EPRTLNPSPAGWFVQQHPELELMSSFRERFGRNWLQYRSHLEPSGN 453
+P+ +DP E R+L S + ++ L+ S ER R R+ L+ + +
Sbjct: 349 DPALSDPVLARRLRENRSLAMSRLDEVISKYAMLQDKSEEGERKKR-----RARLQGTSS 403
Query: 454 PLPATPTTSAPSAPPASSQGPDTAPRPSPPQEEARGPQESPQKMSEEVRAEPQEEEEEKE 513
TP S S S P S + + +ES ++ E +EEEEE+E
Sbjct: 404 HSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEE-------EEEEEEEEEE 456
Query: 514 GKEEKEEGEMVEQGEEEAGEEEEEEQDQKEVEA 546
+ EE E +EQ +E G+E++EE+D++E A
Sbjct: 457 EATDSEEEEDLEQMQE--GQEDDEEEDEEEEAA 487
Score = 32.7 bits (73), Expect = 1.9
Identities = 44/201 (21%), Positives = 78/201 (38%), Gaps = 31/201 (15%)
Query: 451 SGNPLPATPTTSAPSAPPASSQGPDTAPRPSPPQEEARGPQESPQKMSEEVRAEPQEEEE 510
SG + PSA A + D +EE +E EE E +E +
Sbjct: 415 SGEGPSGMASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQ 474
Query: 511 EKEGKE-EKEEGEMVEQGEE--------------EAGEEEEEEQDQKEVEAELCRPLLVC 555
E + +E E+EE + G++ E G++ +++ + + P L+
Sbjct: 475 EDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLS 534
Query: 556 --PL------EGPEGVRGRECFLRVTS--AHLFEVELQAARTLERLELQSLEAAEIEPEA 605
PL G + E L S + LFE+E++A L L + + E + +
Sbjct: 535 EEPLAPSSIDAESNGEQPEELTLEEESPVSQLFELEIEA------LPLDTPSSVETDISS 588
Query: 606 QAQRSPRPTGSDLLPGAPILS 626
++S P + L GA ++S
Sbjct: 589 SRKQSEEPFTTVLENGAGMVS 609
>gi|215422366 death-domain associated protein isoform b [Homo
sapiens]
Length = 752
Score = 52.4 bits (124), Expect = 2e-06
Identities = 28/81 (34%), Positives = 43/81 (53%), Gaps = 1/81 (1%)
Query: 460 TTSAPSAPPASSQGPD-TAPRPSPPQEEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEK 518
+ P A S +GP A + P A E ++ EE E +EEEEE EE+
Sbjct: 417 SADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEE 476
Query: 519 EEGEMVEQGEEEAGEEEEEEQ 539
E+ E +++G+E+ EE+EEE+
Sbjct: 477 EDLEQMQEGQEDDEEEDEEEE 497
Score = 48.5 bits (114), Expect = 3e-05
Identities = 43/153 (28%), Positives = 71/153 (46%), Gaps = 21/153 (13%)
Query: 401 EPSDTDP-------EPRTLNPSPAGWFVQQHPELELMSSFRERFGRNWLQYRSHLEPSGN 453
+P+ +DP E R+L S + ++ L+ S ER R R+ L+ + +
Sbjct: 361 DPALSDPVLARRLRENRSLAMSRLDEVISKYAMLQDKSEEGERKKR-----RARLQGTSS 415
Query: 454 PLPATPTTSAPSAPPASSQGPDTAPRPSPPQEEARGPQESPQKMSEEVRAEPQEEEEEKE 513
TP S S S P S + + +ES ++ E +EEEEE+E
Sbjct: 416 HSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEE-------EEEEEEEEEE 468
Query: 514 GKEEKEEGEMVEQGEEEAGEEEEEEQDQKEVEA 546
+ EE E +EQ +E G+E++EE+D++E A
Sbjct: 469 EATDSEEEEDLEQMQE--GQEDDEEEDEEEEAA 499
Score = 32.7 bits (73), Expect = 1.9
Identities = 44/201 (21%), Positives = 78/201 (38%), Gaps = 31/201 (15%)
Query: 451 SGNPLPATPTTSAPSAPPASSQGPDTAPRPSPPQEEARGPQESPQKMSEEVRAEPQEEEE 510
SG + PSA A + D +EE +E EE E +E +
Sbjct: 427 SGEGPSGMASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQ 486
Query: 511 EKEGKE-EKEEGEMVEQGEE--------------EAGEEEEEEQDQKEVEAELCRPLLVC 555
E + +E E+EE + G++ E G++ +++ + + P L+
Sbjct: 487 EDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLS 546
Query: 556 --PL------EGPEGVRGRECFLRVTS--AHLFEVELQAARTLERLELQSLEAAEIEPEA 605
PL G + E L S + LFE+E++A L L + + E + +
Sbjct: 547 EEPLAPSSIDAESNGEQPEELTLEEESPVSQLFELEIEA------LPLDTPSSVETDISS 600
Query: 606 QAQRSPRPTGSDLLPGAPILS 626
++S P + L GA ++S
Sbjct: 601 SRKQSEEPFTTVLENGAGMVS 621
>gi|239508778 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 123
Score = 52.4 bits (124), Expect = 2e-06
Identities = 26/68 (38%), Positives = 43/68 (63%)
Query: 475 DTAPRPSPPQEEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEE 534
+T R +EE + ++ +K EE R E +EEEEE++ +EEKEEG ++ ++ +E
Sbjct: 48 ETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKE 107
Query: 535 EEEEQDQK 542
EEEE+ +K
Sbjct: 108 EEEEKKKK 115
Score = 48.1 bits (113), Expect = 4e-05
Identities = 23/60 (38%), Positives = 40/60 (66%)
Query: 484 QEEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQDQKE 543
++E R +E +K E + + +EEEE+K ++ K++ E E+ EEE EEEE+E+++KE
Sbjct: 33 RKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKE 92
Score = 40.8 bits (94), Expect = 0.007
Identities = 21/64 (32%), Positives = 39/64 (60%)
Query: 484 QEEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQDQKE 543
+ E R +E +K + R + +EEEE +E +EE+EE + E+ EE ++++++ +KE
Sbjct: 48 ETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKE 107
Query: 544 VEAE 547
E E
Sbjct: 108 EEEE 111
Score = 39.7 bits (91), Expect = 0.016
Identities = 18/73 (24%), Positives = 43/73 (58%)
Query: 475 DTAPRPSPPQEEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEE 534
+T ++E + ++ +K E+ + + +E E+++ KEE+E+ ++ +++ EE
Sbjct: 15 ETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEE 74
Query: 535 EEEEQDQKEVEAE 547
EEE++++E E E
Sbjct: 75 REEEEEEEEEEKE 87
Score = 37.4 bits (85), Expect = 0.079
Identities = 18/55 (32%), Positives = 33/55 (60%)
Query: 491 QESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQDQKEVE 545
++ ++ E E EEEEEKEGK +++ E ++ E++ +E E++ +KE E
Sbjct: 4 KKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEE 58
Score = 37.4 bits (85), Expect = 0.079
Identities = 19/67 (28%), Positives = 41/67 (61%), Gaps = 3/67 (4%)
Query: 484 QEEARGPQESPQK---MSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQD 540
+EE G ++ +K +E + + +E E+ KE +EE+++ + + ++E E EEEE++
Sbjct: 22 EEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEE 81
Query: 541 QKEVEAE 547
++E + E
Sbjct: 82 EEEEKEE 88
Score = 34.7 bits (78), Expect = 0.51
Identities = 15/52 (28%), Positives = 33/52 (63%)
Query: 492 ESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQDQKE 543
E ++ EE E + +E+ KE ++EKE+ + ++ E+ +EEEE++ +++
Sbjct: 14 EETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRK 65
Score = 31.6 bits (70), Expect = 4.3
Identities = 15/50 (30%), Positives = 31/50 (62%)
Query: 496 KMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQDQKEVE 545
K ++ + E +E EE +E +EE+E+ ++ +E +E+E+++ KE E
Sbjct: 1 KKKKKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETE 50
Score = 30.8 bits (68), Expect = 7.4
Identities = 20/58 (34%), Positives = 34/58 (58%), Gaps = 6/58 (10%)
Query: 495 QKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEE-----EEEQDQKEVEAE 547
+K ++ E EE EE E +EE++EG+ E+ +E+ E+E +E + +KE E E
Sbjct: 2 KKKKKKKETEETEETEETE-EEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEE 58
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 52.4 bits (124), Expect = 2e-06
Identities = 42/128 (32%), Positives = 73/128 (57%), Gaps = 8/128 (6%)
Query: 180 NFSYNALTALDSSLRLLSALRFLNLSHNQVQDCQGFLMDLCELHHLDISYNRLHLVP-RM 238
N SYN + ++ +LL LR LNLS+N++ +G + ++C L L+++ N + +P +
Sbjct: 131 NLSYNLIGKIEKLDKLLK-LRELNLSYNKISKIEG-IENMCNLQKLNLAGNEIEHIPVWL 188
Query: 239 GPSGAALGVLILRGNELRSLHGLEQLRNLRHLDLAYNLLEGHRELSPLWL---LAELRKL 295
G +L VL L+GN++ SL + +L+ L+ L ++ L+E P +L + LR L
Sbjct: 189 GKKLKSLRVLNLKGNKISSLQDISKLKPLQDL-ISLILVENPVVTLPHYLQFTIFHLRSL 247
Query: 296 -YLEGNPL 302
LEG P+
Sbjct: 248 ESLEGQPV 255
Score = 36.6 bits (83), Expect = 0.13
Identities = 28/85 (32%), Positives = 46/85 (54%), Gaps = 8/85 (9%)
Query: 221 ELHHLDISYNRLHLVPRMGPSGAALGVLILRGNELRSLHGLEQLRNLRHLDLAYNLLEGH 280
+L L++SYN + + ++ L L L N++ + G+E + NL+ L+LA N +E
Sbjct: 126 KLEVLNLSYNLIGKIEKLDKL-LKLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIEH- 183
Query: 281 RELSPLWL---LAELRKLYLEGNPL 302
P+WL L LR L L+GN +
Sbjct: 184 ---IPVWLGKKLKSLRVLNLKGNKI 205
>gi|4505101 microtubule-associated protein 7 [Homo sapiens]
Length = 749
Score = 52.0 bits (123), Expect = 3e-06
Identities = 79/325 (24%), Positives = 114/325 (35%), Gaps = 54/325 (16%)
Query: 312 TAQYLSPRARDAATGFLLDGKVLSLTDFQTHTSLGLSPMGPP--------LPWPVGSTPE 363
TA Y R R+ VL LT + T +SP P L P S P
Sbjct: 291 TASYKKERERE---------NVLFLT---SGTRRAVSPSNPKARQPARSRLWLPSKSLPH 338
Query: 364 TSGGPDLSDSLSSGGVVTQPLLHKVKSRVRVRRASISEPSDTDPEPRTLNPSPAGWFVQQ 423
G P + SL G V P + S +R + EP +P V
Sbjct: 339 LPGTPRPTSSLPPGSVKAAPAQVRPPSPGNIRPVK----REVKVEPEKKDPEKEPQKVAN 394
Query: 424 HPELELMSSFRERFGRNWLQYRSHLEPSGNPLPATPTTSAPSAP-PASSQGPDTAPRP-- 480
P L+ + + ++ R+ EP P + SAP PAS+ P P P
Sbjct: 395 EPSLKGRAPL-VKVEEATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAM 453
Query: 481 -SPPQEEARG------------PQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQG 527
S P P+E+ + ++E+ R E+ EKE +E +E+ E+ Q
Sbjct: 454 VSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRL--AREQREKEERERREQEELERQK 511
Query: 528 EEEAGEEEEEEQDQKEVEAELCRPLLVCPLEGPEGVRGRECFLRVTSAHLFEVELQAART 587
EE + EE+ + E LE + E R E L+
Sbjct: 512 REELAQRVAEERTTRREEESR-------RLEAEQAREKEEQLQRQAE----ERALREREE 560
Query: 588 LERLELQSLEAAEIEPEAQAQRSPR 612
ER + Q E A + EA+ R R
Sbjct: 561 AERAQRQKEEEARVREEAERVRQER 585
Score = 35.8 bits (81), Expect = 0.23
Identities = 21/68 (30%), Positives = 37/68 (54%), Gaps = 5/68 (7%)
Query: 485 EEARGPQESPQKMSEEVRAEPQEEEEEKEGKEE-----KEEGEMVEQGEEEAGEEEEEEQ 539
E+AR +E Q+ +EE +EE E + ++E +EE E V Q E+ + EE+E+
Sbjct: 537 EQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQER 596
Query: 540 DQKEVEAE 547
+++ E
Sbjct: 597 LERKKRLE 604
>gi|169210053 PREDICTED: hypothetical protein [Homo sapiens]
Length = 185
Score = 51.6 bits (122), Expect = 4e-06
Identities = 33/100 (33%), Positives = 54/100 (54%), Gaps = 11/100 (11%)
Query: 451 SGNPLPATPTTSAPSAPPASSQGPDTAPRPSPPQEEARGPQESPQKMSEEVRAEPQEEEE 510
+GN L T + + ++ QG P EE +E + EE E +E+EE
Sbjct: 93 AGNRLSVARTAALVAEECSAQQGL--------PVEEEEVEEEEEEVEEEEKEEEKEEDEE 144
Query: 511 EKEGKEEKEEGEMVEQGEEEAGEEEEEEQDQKEVEAELCR 550
E+E +EEKEE E+ EE+ G++ EEE+ ++E++ E+ R
Sbjct: 145 EEEKEEEKEED---EEEEEKEGKKMEEEKVEEEIDTEIQR 181
Score = 37.0 bits (84), Expect = 0.10
Identities = 27/103 (26%), Positives = 43/103 (41%), Gaps = 5/103 (4%)
Query: 437 FGRNWLQYRSHLEPSGNPLPATPTTSAPSAPPASSQGPDTAPRPSPPQEEARGPQESPQK 496
+G+N L + L + SA P + + +E+ +E ++
Sbjct: 86 WGKNDLSAGNRLSVARTAALVAEECSAQQGLPVEEEEVEEEEEEVEEEEKEEEKEEDEEE 145
Query: 497 MSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQ 539
+E E EEEEEKEGK+ +E E+ EEE E + Q
Sbjct: 146 EEKEEEKEEDEEEEEKEGKKMEE-----EKVEEEIDTEIQRTQ 183
>gi|61742782 leucine rich repeat and death domain containing protein
isoform 2 [Homo sapiens]
Length = 753
Score = 51.6 bits (122), Expect = 4e-06
Identities = 47/114 (41%), Positives = 61/114 (53%), Gaps = 4/114 (3%)
Query: 182 SYNALTALDSSLRLLSALRFLNLSHNQVQDCQGFLMDLCELHHLDISYNRLH-LVPRMGP 240
S+N L+ L +L L AL FL ++HN++Q L L L LD+S N L L P +G
Sbjct: 10 SHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGG 69
Query: 241 SGAALGVLILRGNELRSL-HGLEQLRNLRHLDLAYNLLEG-HRELSPLWLLAEL 292
G+ L L L N L+SL L LR+LR L L NLL +L+ L LL L
Sbjct: 70 LGSLL-ELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRL 122
Score = 48.5 bits (114), Expect = 3e-05
Identities = 53/152 (34%), Positives = 73/152 (48%), Gaps = 13/152 (8%)
Query: 152 SLQALEELLSACGGDFCSALPWLALLSANFSYNALTALDSSLRLLSALRFLNLSHNQVQD 211
S L EL A G ALP L L+ ++N L L +L LS L+ L+LS N +
Sbjct: 10 SHNCLSELPEALG-----ALPALTFLTV--THNRLQTLPPALGALSTLQRLDLSQNLLDT 62
Query: 212 CQGFLMDLCELHHLDISYNRLHLVPRMGPSGAALGVLILRGNELRSLHG-LEQLRNLRHL 270
+ L L L+++ NRL +P +L +L+L N L S+ L +L L L
Sbjct: 63 LPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRL 122
Query: 271 DLAYNLLEGHRELSPLWLLAELRKLYLEGNPL 302
DL N L R+L P L A + L+GNPL
Sbjct: 123 DLRDNQL---RDLPPELLDAPF--VRLQGNPL 149
>gi|118498345 AT-binding transcription factor 1 [Homo sapiens]
Length = 3703
Score = 51.6 bits (122), Expect = 4e-06
Identities = 42/113 (37%), Positives = 53/113 (46%), Gaps = 14/113 (12%)
Query: 458 TPTTSAP-----SAPPASSQGPDTAPRPSPPQEEARGPQESPQKMSEEVRAEPQEEEEEK 512
TP TS P S+P SS+G D+ QE G S + E E +EEEEE+
Sbjct: 413 TPITSVPLGPLASSPTKSSEGKDSGAAEGEKQEVGDGDCFSEKV--EPAEEEAEEEEEEE 470
Query: 513 EGKEEKEEGEMVEQGEEEAGEEEEEEQDQKEVEAELCRPLLVCPLEGPEGVRG 565
E +EE+EE EEE EEEE+E + +EL L P E P G
Sbjct: 471 EAEEEEEE-------EEEEEEEEEDEGCKGLFPSELDEELEDRPHEEPGAAAG 516
Score = 39.7 bits (91), Expect = 0.016
Identities = 24/112 (21%), Positives = 59/112 (52%), Gaps = 12/112 (10%)
Query: 448 LEPSGNPLPATPTTSAPSAPPASSQGPDTAPRPSPPQEEARGPQESPQKMSEEVRAEPQE 507
+ PS N L PT S P + G + A PS P+E R +K+++ + + Q+
Sbjct: 1673 IAPSSNLLSQVPTESVGMPPLGNPIGANIA-SPSEPKEANR------KKLADMIASRQQQ 1725
Query: 508 EEEEKEGKEEKEEGEMVE-----QGEEEAGEEEEEEQDQKEVEAELCRPLLV 554
++++++ ++++++ + + Q + +A ++E +Q ++++L P L+
Sbjct: 1726 QQQQQQQQQQQQQQQQAQTLAQAQAQVQAHLQQELQQQAALIQSQLFNPTLL 1777
Score = 36.2 bits (82), Expect = 0.18
Identities = 32/147 (21%), Positives = 64/147 (43%), Gaps = 13/147 (8%)
Query: 454 PLPATPTTSAPSAPPASSQGPDTAPRPSPPQEE-ARGPQESPQKMSEEVRAEPQEEEEEK 512
P P PT+ P+ P ++S P+P Q A GPQ+ PQ+ ++ + + Q+
Sbjct: 3160 PSPGLPTSGLPNKPSSAS-----LSSPTPAQATMAMGPQQPPQQQQQQQQPQVQQPPPPP 3214
Query: 513 EGKEEKEEGEMVEQGEEEAGEEEEEEQDQKEVEAELCRPLLVCPLEGPEGVRGRECFLRV 572
+ ++Q ++ ++ E+ +++++ PL P+ E
Sbjct: 3215 AAQPPPTPQLPLQQQQQRKDKDSEKVKEKEKAHKGKGEPL---PVPKKEKGEAPTATAAT 3271
Query: 573 TSAHLFEVELQAARTLERLELQSLEAA 599
SA L +E ++ +LQ+L+AA
Sbjct: 3272 ISAPLPTMEY----AVDPAQLQALQAA 3294
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 51.6 bits (122), Expect = 4e-06
Identities = 53/200 (26%), Positives = 79/200 (39%), Gaps = 33/200 (16%)
Query: 450 PSGNPLPATPTTSA------PSAPPA--------------SSQGPDTAPRPSPPQEE--- 486
P G+P P P SA P PPA S PRP+PPQEE
Sbjct: 29 PEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQLPLEPESPSGQVGPRPAPPQEESPS 88
Query: 487 ----ARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQDQK 542
+RGP +P M P+ + + +Q ++AGE + ++++
Sbjct: 89 SEAKSRGP--TPPAMGPRDARPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLAKERR 146
Query: 543 EVEAELCRPLLVCPLEGPEGVRG-RECFLRVTSAHLFEVELQAAR---TLERLELQSLEA 598
E A+ LE E + RE L+ L E L+A + LE + Q LE
Sbjct: 147 EERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKLEK 206
Query: 599 AEIEPEAQAQRSPRPTGSDL 618
+ EA QRS + T +++
Sbjct: 207 NKERYEAAIQRSVKKTWAEI 226
Score = 45.1 bits (105), Expect = 4e-04
Identities = 46/158 (29%), Positives = 70/158 (44%), Gaps = 9/158 (5%)
Query: 462 SAPSAPPASSQGPDTAPRPSPPQEE---ARGPQESPQKMSEEVRAEPQEEEEEKEGKEEK 518
SA A PA S P +P P+PPQ+E A P ++ S A P + G ++
Sbjct: 539 SAAPASPAPSPAP--SPTPAPPQKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDR 596
Query: 519 EEG-EMVEQGEEEAGEEEEEEQDQKEVEAELCRPLLVCPLEGPEGVRG-RECFLRVTSAH 576
EE ++ + +A E+ E E+ ++ ++AE + + L R RE R
Sbjct: 597 EEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQ 656
Query: 577 LFEVELQAAR-TLERLELQSLEA-AEIEPEAQAQRSPR 612
+ QA + ERL+ Q EA A EA+ QR R
Sbjct: 657 EAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLER 694
Score = 41.6 bits (96), Expect = 0.004
Identities = 59/277 (21%), Positives = 98/277 (35%), Gaps = 48/277 (17%)
Query: 349 PMGPPLPWPVGSTPETSGGPDLS---DSLSSGGVVTQPLLHKVKSRVRVRRASISEPSDT 405
P P W ++P S GP + S G P K RVR + + PS
Sbjct: 467 PSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASP-----KGRVRRKEEAKESPSAA 521
Query: 406 DPEPRTLNPSPAGWFVQQHPELELMSSFRERFGRNWLQYRSHLEPSGNPLPATPTTSAPS 465
PE ++ + A + S P+ +P PA P P
Sbjct: 522 GPEDKSQSKRRASNEKESAAPASPAPS-----------------PAPSPTPAPPQKEQPP 564
Query: 466 APPASSQGPDTAP-------RPSPPQEEARGPQESPQKMSE---EVRAEPQEEEEEKEGK 515
A + T+P PS P +E+ + ++E + R + + EE+E+ +
Sbjct: 565 AETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQ 624
Query: 516 EEKEEGEMVEQGEEEAGEEEEEEQDQKEVEAELCRPLLVCPLEGPEGVRGRECFLRVTSA 575
E+++ EQ EA E E + + E + R E E ++ ++
Sbjct: 625 AERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQK-------- 676
Query: 576 HLFEVELQAARTLERLELQSLEAAEIEPEAQAQRSPR 612
E AR+ E E Q LE + + + +R R
Sbjct: 677 -----EEAEARSREEAERQRLEREKHFQQQEQERQER 708
Score = 35.4 bits (80), Expect = 0.30
Identities = 26/89 (29%), Positives = 40/89 (44%), Gaps = 9/89 (10%)
Query: 446 SHLEPSGNPLPATPTTS--APSAP-PASSQGPDTAPRPSPPQEEARGPQESPQKMSEEVR 502
S L P P++P+TS P++P P+ G P+P P RG SP+ R
Sbjct: 457 SELSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSP----RGTTASPK--GRVRR 510
Query: 503 AEPQEEEEEKEGKEEKEEGEMVEQGEEEA 531
E +E G E+K + + E+E+
Sbjct: 511 KEEAKESPSAAGPEDKSQSKRRASNEKES 539
Score = 32.7 bits (73), Expect = 1.9
Identities = 16/62 (25%), Positives = 35/62 (56%), Gaps = 1/62 (1%)
Query: 484 QEEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQDQKE 543
+EE +++ + E+ R + Q+EE E +EE E + +E+ + +E+E ++ +K
Sbjct: 653 REEQEAREKAQAEQEEQERLQKQKEEAEARSREEAER-QRLEREKHFQQQEQERQERRKR 711
Query: 544 VE 545
+E
Sbjct: 712 LE 713
Score = 32.3 bits (72), Expect = 2.5
Identities = 18/68 (26%), Positives = 37/68 (54%), Gaps = 2/68 (2%)
Query: 484 QEEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQDQKE 543
+ EAR +E+ ++ E + Q+E+E +E ++ E E++++ + E +++QD KE
Sbjct: 678 EAEARSREEAERQRLEREKHFQQQEQERQERRKRLE--EIMKRTRKSEVSETKQKQDSKE 735
Query: 544 VEAELCRP 551
A P
Sbjct: 736 ANANGSSP 743
>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
Length = 811
Score = 50.8 bits (120), Expect = 7e-06
Identities = 77/245 (31%), Positives = 104/245 (42%), Gaps = 48/245 (19%)
Query: 76 HPADSPVILQLQFLFDVLQKTLSLKLVHVAGPGPTGPIKIFPFKSLRHLELRGVPLHCLH 135
HP + +L+ L+ L L+ PG P++ LR L G + L
Sbjct: 99 HPKTFEKLSRLEELY------LGNNLLQALAPGTLAPLR-----KLRILYANGNEISRLS 147
Query: 136 GLRGIYSQLETLICSR----SLQALEELLSACGGDFCSALPWLALLSANFSYNALTALD- 190
RG + LE+L+ R +L AL + + A G+ LL + N + L
Sbjct: 148 --RGSFEGLESLVKLRLDGNALGALPDAVFAPLGN---------LLYLHLESNRIRFLGK 196
Query: 191 SSLRLLSALRFLNLSHNQVQDC---QGFLMDLCELHHLDISYNRL-HLVPRMGPSGAALG 246
++ L LRFLNLS N++Q L L L +S N L HL PR+ LG
Sbjct: 197 NAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLG 256
Query: 247 VLILRGNELRSL-----HGLEQLRNLRHLDLAYNLLEGHR----ELSPLWLLAELRKLYL 297
+L LRGN+L L GLE LR LR LEG+R + L L L L L
Sbjct: 257 LLSLRGNQLTHLAPEAFWGLEALRELR--------LEGNRLSQLPTALLEPLHSLEALDL 308
Query: 298 EGNPL 302
GN L
Sbjct: 309 SGNEL 313
>gi|239745093 PREDICTED: hypothetical protein XP_002343359 [Homo
sapiens]
Length = 142
Score = 50.4 bits (119), Expect = 9e-06
Identities = 35/91 (38%), Positives = 48/91 (52%), Gaps = 10/91 (10%)
Query: 460 TTSAPSAPPASSQG-PDTAPRPSPPQEEARGPQESPQKMSEEVRAEPQEEEEEKEGKE-E 517
T+S PP T+ R S +EE R E+ R E + EE+ +EGK E
Sbjct: 43 TSSVKEEPPTLRHSMAGTSARKSQRREEKR--------REEKRREEKRREEKRREGKRRE 94
Query: 518 KEEGEMVEQGEEEAGEEEEEEQDQKEVEAEL 548
KEE + E+ EEE EEEEEE++++EV L
Sbjct: 95 KEEEKEEEEEEEEEEEEEEEEEEEEEVSFSL 125
Score = 39.7 bits (91), Expect = 0.016
Identities = 30/94 (31%), Positives = 43/94 (45%), Gaps = 9/94 (9%)
Query: 456 PATPTTSAPSAPPASSQGPDTAPRPSPPQEEARGPQESPQKMSEEVRAEPQEEEEEKEGK 515
P T S SQ + R +EE R ++ + E E +EEEEE+E +
Sbjct: 50 PPTLRHSMAGTSARKSQRREEKRREEKRREEKRREEKRREGKRREKEEEKEEEEEEEEEE 109
Query: 516 EEKEEGEMVEQGEEE-----AGEEEEEEQDQKEV 544
EE+EE E+ EEE A E E E ++K +
Sbjct: 110 EEEEE----EEEEEEVSFSLATRERETETEEKRL 139
>gi|113204617 skeletal muscle ryanodine receptor isoform 2 [Homo
sapiens]
Length = 5033
Score = 50.4 bits (119), Expect = 9e-06
Identities = 33/77 (42%), Positives = 43/77 (55%), Gaps = 2/77 (2%)
Query: 494 PQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQDQKEVEAELCRPLL 553
P+ +EE E +EEE E+E +EEKEE E E+E E+EEEE + E E L LL
Sbjct: 1868 PEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLL 1927
Query: 554 VCPLEGPEGVRGRECFL 570
L PE V+ + C L
Sbjct: 1928 QMKL--PESVKLQMCHL 1942
Score = 40.0 bits (92), Expect = 0.012
Identities = 42/140 (30%), Positives = 64/140 (45%), Gaps = 12/140 (8%)
Query: 478 PRPSPPQEEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEE 537
P +EE +E ++ EE + E +EE +++ EEKEE E E GE+E G EE
Sbjct: 1868 PEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAE-GEKEEGLEEGL 1926
Query: 538 EQDQ--KEVEAELCRPL-LVCPLEGPEGVRGRECFLRVTSAHLFEVELQA---ARTLERL 591
Q + + V+ ++C L C E V F A + +LQA +R +
Sbjct: 1927 LQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAF-----AERYVDKLQANQRSRYGLLI 1981
Query: 592 ELQSLEAAEIEPEAQAQRSP 611
+ S+ AAE + RSP
Sbjct: 1982 KAFSMTAAETARRTREFRSP 2001
Score = 32.3 bits (72), Expect = 2.5
Identities = 29/97 (29%), Positives = 40/97 (41%), Gaps = 6/97 (6%)
Query: 452 GNPLPATPTTSAPSAPPASSQGPDTAPRPSPPQEEARGPQESPQKMSEEVRAEPQEEEEE 511
G+ PA P T S G D PP+ E P+ P+ E+ AE E+EE
Sbjct: 4453 GDTTPAEPPTPEGSPILKRKLGVDGVEEELPPEPE---PEPEPELEPEKADAENGEKEEV 4509
Query: 512 KEGKEE---KEEGEMVEQGEEEAGEEEEEEQDQKEVE 545
E E K+ +EEAG E E + + V+
Sbjct: 4510 PEPTPEPPKKQAPPSPPPKKEEAGGEFWGELEVQRVK 4546
>gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo
sapiens]
Length = 5038
Score = 50.4 bits (119), Expect = 9e-06
Identities = 33/77 (42%), Positives = 43/77 (55%), Gaps = 2/77 (2%)
Query: 494 PQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQDQKEVEAELCRPLL 553
P+ +EE E +EEE E+E +EEKEE E E+E E+EEEE + E E L LL
Sbjct: 1868 PEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLL 1927
Query: 554 VCPLEGPEGVRGRECFL 570
L PE V+ + C L
Sbjct: 1928 QMKL--PESVKLQMCHL 1942
Score = 40.0 bits (92), Expect = 0.012
Identities = 42/140 (30%), Positives = 64/140 (45%), Gaps = 12/140 (8%)
Query: 478 PRPSPPQEEARGPQESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEE 537
P +EE +E ++ EE + E +EE +++ EEKEE E E GE+E G EE
Sbjct: 1868 PEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAE-GEKEEGLEEGL 1926
Query: 538 EQDQ--KEVEAELCRPL-LVCPLEGPEGVRGRECFLRVTSAHLFEVELQA---ARTLERL 591
Q + + V+ ++C L C E V F A + +LQA +R +
Sbjct: 1927 LQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAF-----AERYVDKLQANQRSRYGLLI 1981
Query: 592 ELQSLEAAEIEPEAQAQRSP 611
+ S+ AAE + RSP
Sbjct: 1982 KAFSMTAAETARRTREFRSP 2001
Score = 32.3 bits (72), Expect = 2.5
Identities = 29/97 (29%), Positives = 40/97 (41%), Gaps = 6/97 (6%)
Query: 452 GNPLPATPTTSAPSAPPASSQGPDTAPRPSPPQEEARGPQESPQKMSEEVRAEPQEEEEE 511
G+ PA P T S G D PP+ E P+ P+ E+ AE E+EE
Sbjct: 4458 GDTTPAEPPTPEGSPILKRKLGVDGVEEELPPEPE---PEPEPELEPEKADAENGEKEEV 4514
Query: 512 KEGKEE---KEEGEMVEQGEEEAGEEEEEEQDQKEVE 545
E E K+ +EEAG E E + + V+
Sbjct: 4515 PEPTPEPPKKQAPPSPPPKKEEAGGEFWGELEVQRVK 4551
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,751,593
Number of Sequences: 37866
Number of extensions: 3004820
Number of successful extensions: 63246
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 839
Number of HSP's successfully gapped in prelim test: 1134
Number of HSP's that attempted gapping in prelim test: 27690
Number of HSP's gapped (non-prelim): 20333
length of query: 1099
length of database: 18,247,518
effective HSP length: 113
effective length of query: 986
effective length of database: 13,968,660
effective search space: 13773098760
effective search space used: 13773098760
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.