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Search of human proteins with 23199987
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|23199987 WD repeat domain 5B [Homo sapiens]
(330 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|23199987 WD repeat domain 5B [Homo sapiens] 682 0.0
gi|16554629 WD repeat domain 5 [Homo sapiens] 587 e-168
gi|16554627 WD repeat domain 5 [Homo sapiens] 587 e-168
gi|32189425 WD repeat domain 69 [Homo sapiens] 186 2e-47
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 179 4e-45
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 173 2e-43
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 160 1e-39
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 160 1e-39
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 160 1e-39
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 156 3e-38
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 156 3e-38
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 156 3e-38
gi|153791298 mitogen-activated protein kinase organizer 1 [Homo ... 154 1e-37
gi|14150114 mitogen-activated protein kinase organizer 1 [Homo s... 154 1e-37
gi|26665869 WD repeat domain 51B [Homo sapiens] 150 1e-36
gi|21071067 TBP-associated factor 5 [Homo sapiens] 144 8e-35
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ... 138 8e-33
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 137 1e-32
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 137 2e-32
gi|113865883 WD repeat domain 38 [Homo sapiens] 134 1e-31
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 130 2e-30
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 129 5e-30
gi|7706657 cell division cycle 40 homolog [Homo sapiens] 126 3e-29
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 126 3e-29
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 126 3e-29
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 126 3e-29
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 124 9e-29
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 123 3e-28
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 122 4e-28
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 121 1e-27
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 682 bits (1759), Expect = 0.0
Identities = 330/330 (100%), Positives = 330/330 (100%)
Query: 1 MATKESRDAKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSS 60
MATKESRDAKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSS
Sbjct: 1 MATKESRDAKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSS 60
Query: 61 ADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKT 120
ADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKT
Sbjct: 61 ADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKT 120
Query: 121 LKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGS 180
LKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGS
Sbjct: 121 LKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGS 180
Query: 181 LIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYS 240
LIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYS
Sbjct: 181 LIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYS 240
Query: 241 RGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 300
RGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV
Sbjct: 241 RGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 300
Query: 301 ISAACHPTENLIASAALENDKTIKLWMSNH 330
ISAACHPTENLIASAALENDKTIKLWMSNH
Sbjct: 301 ISAACHPTENLIASAALENDKTIKLWMSNH 330
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 587 bits (1514), Expect = e-168
Identities = 284/333 (85%), Positives = 302/333 (90%), Gaps = 4/333 (1%)
Query: 1 MATKESRD----AKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWL 56
MAT+E + A+AQ SSSA QSK P PNYALK TL GHT+AVSSVKFSPNGEWL
Sbjct: 1 MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL 60
Query: 57 ASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGK 116
ASSSAD+LI IWGAYDGK+EKT+ GH L ISDVAWSSDS+ LVSASDDKTLK+WDV SGK
Sbjct: 61 ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK 120
Query: 117 CLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFN 176
CLKTLKGHSNYVFCCNFNP SNLI+SGSFDE+V+IW+VKTGKCLKTL AHSDPVSAVHFN
Sbjct: 121 CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN 180
Query: 177 CSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKL 236
GSLIVS SYDGLCRIWD ASGQCLKTL+DDDNPPVSFVKFSPNGKYIL ATLDNTLKL
Sbjct: 181 RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL 240
Query: 237 WDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 296
WDYS+G+CLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH
Sbjct: 241 WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 300
Query: 297 TDVVISAACHPTENLIASAALENDKTIKLWMSN 329
TDVVIS ACHPTEN+IASAALENDKTIKLW S+
Sbjct: 301 TDVVISTACHPTENIIASAALENDKTIKLWKSD 333
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 587 bits (1514), Expect = e-168
Identities = 284/333 (85%), Positives = 302/333 (90%), Gaps = 4/333 (1%)
Query: 1 MATKESRD----AKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWL 56
MAT+E + A+AQ SSSA QSK P PNYALK TL GHT+AVSSVKFSPNGEWL
Sbjct: 1 MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL 60
Query: 57 ASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGK 116
ASSSAD+LI IWGAYDGK+EKT+ GH L ISDVAWSSDS+ LVSASDDKTLK+WDV SGK
Sbjct: 61 ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK 120
Query: 117 CLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFN 176
CLKTLKGHSNYVFCCNFNP SNLI+SGSFDE+V+IW+VKTGKCLKTL AHSDPVSAVHFN
Sbjct: 121 CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN 180
Query: 177 CSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKL 236
GSLIVS SYDGLCRIWD ASGQCLKTL+DDDNPPVSFVKFSPNGKYIL ATLDNTLKL
Sbjct: 181 RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL 240
Query: 237 WDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 296
WDYS+G+CLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH
Sbjct: 241 WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 300
Query: 297 TDVVISAACHPTENLIASAALENDKTIKLWMSN 329
TDVVIS ACHPTEN+IASAALENDKTIKLW S+
Sbjct: 301 TDVVISTACHPTENIIASAALENDKTIKLWKSD 333
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 186 bits (473), Expect = 2e-47
Identities = 100/292 (34%), Positives = 163/292 (55%), Gaps = 7/292 (2%)
Query: 36 TLVGHTEAVSSVKFS-PNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSD 94
TL GH V ++ F+ P G+ +A+ S D+ +W GK T GH EI ++++
Sbjct: 129 TLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQ 188
Query: 95 SSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEV 154
S+ + + S D T KLWD+++G+ + TL+GHS + +FN + II+GSFD TV +W+
Sbjct: 189 STLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDA 248
Query: 155 KTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVS 214
TG+ + L H +S+ FN SLI++GS D C++WDA +G+C+ TL D+ +
Sbjct: 249 DTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILD 308
Query: 215 FVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS 274
F GK I TA+ D T +++ + +C+ GH+ E I N G +++GS
Sbjct: 309 SC-FDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFN---PQGNHLLTGS 364
Query: 275 EDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
D IW+ QT + +Q L+GHTD + S A + N++ + + D T ++W
Sbjct: 365 SDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGS--KDNTCRIW 414
Score = 180 bits (456), Expect = 2e-45
Identities = 97/300 (32%), Positives = 165/300 (55%), Gaps = 7/300 (2%)
Query: 28 NPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEIS 87
N + L L H +++V + +G + S DR +W G+ TL GH +
Sbjct: 79 NHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVY 138
Query: 88 DVAWSSD-SSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFD 146
+A+++ ++ + S DKT KLW V +GKC T +GH+ + C +FNP S L+ +GS D
Sbjct: 139 AIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMD 198
Query: 147 ETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLV 206
T K+W+++ G+ + TL HS + ++ FN SG I++GS+D +WDA +G+ + L+
Sbjct: 199 TTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILI 258
Query: 207 DDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTG 266
+S F+ + ILT ++D T KLWD + G+C+ T TGH +E + + F T
Sbjct: 259 -GHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDE--ILDSCFDYT- 314
Query: 267 GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
GK I + S D I++ T++ + KL+GH + + +P N + + + +DKT ++W
Sbjct: 315 GKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGS--SDKTARIW 372
Score = 97.8 bits (242), Expect = 1e-20
Identities = 48/140 (34%), Positives = 83/140 (59%)
Query: 13 LALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYD 72
L L+ S +++ ++ + N TL GH + + F G+ +A++SAD I+ A
Sbjct: 275 LILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAAT 334
Query: 73 GKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCN 132
K L GH EIS ++++ + L++ S DKT ++WD ++G+CL+ L+GH++ +F C
Sbjct: 335 RKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCA 394
Query: 133 FNPPSNLIISGSFDETVKIW 152
FN N++I+GS D T +IW
Sbjct: 395 FNYKGNIVITGSKDNTCRIW 414
Score = 53.1 bits (126), Expect = 3e-07
Identities = 28/103 (27%), Positives = 50/103 (48%)
Query: 8 DAKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIII 67
D +L ++SA+ + + L GH +S + F+P G L + S+D+ I
Sbjct: 312 DYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARI 371
Query: 68 WGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLW 110
W A G+ + L GH EI A++ + +++ S D T ++W
Sbjct: 372 WDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 179 bits (453), Expect = 4e-45
Identities = 105/339 (30%), Positives = 169/339 (49%), Gaps = 25/339 (7%)
Query: 8 DAKAQLALSSSANQSKEVPE-NPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLII 66
+AK + Q ++ E P K L GH V+ V F P + S+S D I
Sbjct: 74 EAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIK 133
Query: 67 IWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSN 126
+W G +E+TL GH + D+++ L S S D T+KLWD + +C++T+ GH +
Sbjct: 134 VWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDH 193
Query: 127 YVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGS 186
V P + I+S S D+T+K+WEV+TG C+KT + H + V V N G+LI S S
Sbjct: 194 NVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCS 253
Query: 187 YDGLCRIWDAASGQCLKTLVDDDN--------PPVSFVKFS-----------PNGKYILT 227
D R+W A+ +C L + ++ P S+ S G ++L+
Sbjct: 254 NDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLS 313
Query: 228 ATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTK 287
+ D T+K+WD S G CL T GH N + + +GGK+I+S ++D + +W+ + K
Sbjct: 314 GSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFH---SGGKFILSCADDKTLRVWDYKNK 370
Query: 288 EIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
++ L H V S H T + + ++ D+T+K+W
Sbjct: 371 RCMKTLNAHEHFVTSLDFHKTAPYVVTGSV--DQTVKVW 407
Score = 135 bits (340), Expect = 5e-32
Identities = 78/253 (30%), Positives = 131/253 (51%), Gaps = 21/253 (8%)
Query: 6 SRDAKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLI 65
S D +L S SA+ + ++ + + T+ GH VSSV PNG+ + S+S D+ I
Sbjct: 157 SFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTI 216
Query: 66 IIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHS 125
+W G KT GH + V + D + + S S+D+T+++W V + +C L+ H
Sbjct: 217 KMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHE 276
Query: 126 NYVFCCNFNP--------------------PSNLIISGSFDETVKIWEVKTGKCLKTLSA 165
+ V C ++ P P ++SGS D+T+K+W+V TG CL TL
Sbjct: 277 HVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVG 336
Query: 166 HSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYI 225
H + V V F+ G I+S + D R+WD + +C+KTL ++ V+ + F Y+
Sbjct: 337 HDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEH-FVTSLDFHKTAPYV 395
Query: 226 LTATLDNTLKLWD 238
+T ++D T+K+W+
Sbjct: 396 VTGSVDQTVKVWE 408
Score = 88.6 bits (218), Expect = 7e-18
Identities = 52/165 (31%), Positives = 85/165 (51%), Gaps = 6/165 (3%)
Query: 163 LSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNG 222
LS H PV+ V F+ S++VS S D ++WD +G +TL + V + F +G
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDS-VQDISFDHSG 162
Query: 223 KYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW 282
K + + + D T+KLWD+ C++T GH + + + G IVS S D + +W
Sbjct: 163 KLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAI---MPNGDHIVSASRDKTIKMW 219
Query: 283 NLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLWM 327
+QT V+ GH + V + LIAS + ND+T+++W+
Sbjct: 220 EVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCS--NDQTVRVWV 262
Score = 86.3 bits (212), Expect = 3e-17
Identities = 51/157 (32%), Positives = 86/157 (54%), Gaps = 11/157 (7%)
Query: 1 MATKESRDAKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSV--KFSPNGEWLAS 58
+ATKE KA+L + + V E ++A + + +EA S K G +L S
Sbjct: 263 VATKE---CKAEL------REHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLS 313
Query: 59 SSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCL 118
S D+ I +W G TL GH+ + V + S ++S +DDKTL++WD ++ +C+
Sbjct: 314 GSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCM 373
Query: 119 KTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVK 155
KTL H ++V +F+ + +++GS D+TVK+WE +
Sbjct: 374 KTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 173 bits (438), Expect = 2e-43
Identities = 102/288 (35%), Positives = 160/288 (55%), Gaps = 11/288 (3%)
Query: 37 LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAY-DGKYEKTLYGHNLEISDVAWSSDS 95
L GH V KF PNG LAS+ DRLI++W Y D TL GH+ + ++ +++D
Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDG 121
Query: 96 SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCN-FNPPSNLIISGSFDETVKIWEV 154
S L SAS DKT+ +WD +G+ +K LKGH+++V C L+ +GS D TVK+W++
Sbjct: 122 SMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI 181
Query: 155 KTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVS 214
+ ++T ++ V AV FN + I+SG D ++WD + T+ + V+
Sbjct: 182 RKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADS-VT 239
Query: 215 FVKFSPNGKYILTATLDNTLKLWDYS----RGRCLKTYTG--HKNEKYCIFANFSVTGGK 268
+ S G Y+L+ +DNT+++WD + RC+K + G H EK + ++S G K
Sbjct: 240 GLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSK 299
Query: 269 WIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAA 316
I +GS D VY+W+ ++ I+ KL GH + A HP E +I SA+
Sbjct: 300 -IAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISAS 346
Score = 107 bits (267), Expect = 1e-23
Identities = 60/208 (28%), Positives = 105/208 (50%), Gaps = 9/208 (4%)
Query: 121 LKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKC--LKTLSAHSDPVSAVHFNCS 178
L GH V+CC F+P + + S FD + +W V G C TL HS V +H+N
Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-GDCDNYATLKGHSGAVMELHYNTD 120
Query: 179 GSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWD 238
GS++ S S D +WD+ +G+ +K L + S + + T + D T+KLWD
Sbjct: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180
Query: 239 YSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTD 298
+ ++T+ +N + F+ T + I+SG DN + +W+L+ ++ ++GH D
Sbjct: 181 IRKKAAIQTF---QNTYQVLAVTFNDTSDQ-IISGGIDNDIKVWDLRQNKLTYTMRGHAD 236
Query: 299 VVISAACHPTENLIASAALENDKTIKLW 326
V + + + S A++N T+++W
Sbjct: 237 SVTGLSLSSEGSYLLSNAMDN--TVRVW 262
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 160 bits (405), Expect = 1e-39
Identities = 96/299 (32%), Positives = 167/299 (55%), Gaps = 34/299 (11%)
Query: 37 LVGHTE-AVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSD- 94
L GH + ++ ++F G + S S D + +W A GK +TL GH + WSS
Sbjct: 258 LKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV----WSSQM 311
Query: 95 -SSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWE 153
+ ++S S D+TLK+W+ +G+C+ TL GH++ V C + + ++SGS D T+++W+
Sbjct: 312 RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVWD 369
Query: 154 VKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPV 213
++TG+CL L H V V ++ G +VSG+YD + ++WD + CL TL N
Sbjct: 370 IETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 427
Query: 214 SFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGG-----K 268
S ++F +G ++++ +LD ++++WD G C+ T TGH+ S+T G
Sbjct: 428 S-LQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQ----------SLTSGMELKDN 474
Query: 269 WIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAAC-HPTENLIASAALENDKTIKLW 326
+VSG+ D+ V IW+++T + +Q LQG + C +N + +++ +D T+KLW
Sbjct: 475 ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSS--DDGTVKLW 531
Score = 152 bits (384), Expect = 4e-37
Identities = 90/265 (33%), Positives = 144/265 (54%), Gaps = 21/265 (7%)
Query: 34 KC--TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAW 91
KC TLVGHT V S + N + S S DR + +W A G+ TLYGH +
Sbjct: 294 KCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVR--CM 349
Query: 92 SSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKI 151
R+VS S D TL++WD+ +G+CL L GH V C ++ ++SG++D VK+
Sbjct: 350 HLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKV 407
Query: 152 WEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNP 211
W+ +T CL TL H++ V ++ F+ G +VSGS D R+WD +G C+ TL +
Sbjct: 408 WDPETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSL 465
Query: 212 PVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTG---HKNEKYCIFANFSVTGGK 268
S ++ N +++ D+T+K+WD G+CL+T G H++ C+ N
Sbjct: 466 -TSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFN-----KN 517
Query: 269 WIVSGSEDNLVYIWNLQTKEIVQKL 293
++++ S+D V +W+L+T E ++ L
Sbjct: 518 FVITSSDDGTVKLWDLKTGEFIRNL 542
Score = 147 bits (372), Expect = 1e-35
Identities = 87/259 (33%), Positives = 136/259 (52%), Gaps = 17/259 (6%)
Query: 68 WGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNY 127
W + K K L GH+ + +R+VS SDD TLK+W +GKCL+TL GH+
Sbjct: 247 WRRGELKSPKVLKGHDDHVI-TCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG 305
Query: 128 VFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSY 187
V+ N+IISGS D T+K+W +TG+C+ TL H+ V +H + +VSGS
Sbjct: 306 VWSSQMR--DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH--EKRVVSGSR 361
Query: 188 DGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKT 247
D R+WD +GQCL L+ V V++ +G+ +++ D +K+WD CL T
Sbjct: 362 DATLRVWDIETGQCLHVLM-GHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHT 418
Query: 248 YTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHP 307
GH N Y + + G +VSGS D + +W+++T + L GH +++
Sbjct: 419 LQGHTNRVYSLQFD-----GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMEL 471
Query: 308 TENLIASAALENDKTIKLW 326
+N++ S D T+K+W
Sbjct: 472 KDNILVSG--NADSTVKIW 488
Score = 105 bits (261), Expect = 7e-23
Identities = 56/173 (32%), Positives = 96/173 (55%), Gaps = 11/173 (6%)
Query: 37 LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSS 96
L+GH AV V++ +G + S + D ++ +W TL GH + + + D
Sbjct: 379 LMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGI 434
Query: 97 RLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKT 156
+VS S D ++++WDV +G C+ TL GH + N+++SG+ D TVKIW++KT
Sbjct: 435 HVVSGSLDTSIRVWDVETGNCIHTLTGHQSLT--SGMELKDNILVSGNADSTVKIWDIKT 492
Query: 157 GKCLKTLSA---HSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLV 206
G+CL+TL H V+ + FN + +++ S DG ++WD +G+ ++ LV
Sbjct: 493 GQCLQTLQGPNKHQSAVTCLQFN--KNFVITSSDDGTVKLWDLKTGEFIRNLV 543
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 160 bits (405), Expect = 1e-39
Identities = 96/299 (32%), Positives = 167/299 (55%), Gaps = 34/299 (11%)
Query: 37 LVGHTE-AVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSD- 94
L GH + ++ ++F G + S S D + +W A GK +TL GH + WSS
Sbjct: 376 LKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV----WSSQM 429
Query: 95 -SSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWE 153
+ ++S S D+TLK+W+ +G+C+ TL GH++ V C + + ++SGS D T+++W+
Sbjct: 430 RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVWD 487
Query: 154 VKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPV 213
++TG+CL L H V V ++ G +VSG+YD + ++WD + CL TL N
Sbjct: 488 IETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 545
Query: 214 SFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGG-----K 268
S ++F +G ++++ +LD ++++WD G C+ T TGH+ S+T G
Sbjct: 546 S-LQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQ----------SLTSGMELKDN 592
Query: 269 WIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAAC-HPTENLIASAALENDKTIKLW 326
+VSG+ D+ V IW+++T + +Q LQG + C +N + +++ +D T+KLW
Sbjct: 593 ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSS--DDGTVKLW 649
Score = 152 bits (384), Expect = 4e-37
Identities = 90/265 (33%), Positives = 144/265 (54%), Gaps = 21/265 (7%)
Query: 34 KC--TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAW 91
KC TLVGHT V S + N + S S DR + +W A G+ TLYGH +
Sbjct: 412 KCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVR--CM 467
Query: 92 SSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKI 151
R+VS S D TL++WD+ +G+CL L GH V C ++ ++SG++D VK+
Sbjct: 468 HLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKV 525
Query: 152 WEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNP 211
W+ +T CL TL H++ V ++ F+ G +VSGS D R+WD +G C+ TL +
Sbjct: 526 WDPETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSL 583
Query: 212 PVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTG---HKNEKYCIFANFSVTGGK 268
S ++ N +++ D+T+K+WD G+CL+T G H++ C+ N
Sbjct: 584 -TSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFN-----KN 635
Query: 269 WIVSGSEDNLVYIWNLQTKEIVQKL 293
++++ S+D V +W+L+T E ++ L
Sbjct: 636 FVITSSDDGTVKLWDLKTGEFIRNL 660
Score = 147 bits (372), Expect = 1e-35
Identities = 87/259 (33%), Positives = 136/259 (52%), Gaps = 17/259 (6%)
Query: 68 WGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNY 127
W + K K L GH+ + +R+VS SDD TLK+W +GKCL+TL GH+
Sbjct: 365 WRRGELKSPKVLKGHDDHVI-TCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG 423
Query: 128 VFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSY 187
V+ N+IISGS D T+K+W +TG+C+ TL H+ V +H + +VSGS
Sbjct: 424 VWSSQMR--DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH--EKRVVSGSR 479
Query: 188 DGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKT 247
D R+WD +GQCL L+ V V++ +G+ +++ D +K+WD CL T
Sbjct: 480 DATLRVWDIETGQCLHVLM-GHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHT 536
Query: 248 YTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHP 307
GH N Y + + G +VSGS D + +W+++T + L GH +++
Sbjct: 537 LQGHTNRVYSLQFD-----GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMEL 589
Query: 308 TENLIASAALENDKTIKLW 326
+N++ S D T+K+W
Sbjct: 590 KDNILVSG--NADSTVKIW 606
Score = 105 bits (261), Expect = 7e-23
Identities = 56/173 (32%), Positives = 96/173 (55%), Gaps = 11/173 (6%)
Query: 37 LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSS 96
L+GH AV V++ +G + S + D ++ +W TL GH + + + D
Sbjct: 497 LMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGI 552
Query: 97 RLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKT 156
+VS S D ++++WDV +G C+ TL GH + N+++SG+ D TVKIW++KT
Sbjct: 553 HVVSGSLDTSIRVWDVETGNCIHTLTGHQSLT--SGMELKDNILVSGNADSTVKIWDIKT 610
Query: 157 GKCLKTLSA---HSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLV 206
G+CL+TL H V+ + FN + +++ S DG ++WD +G+ ++ LV
Sbjct: 611 GQCLQTLQGPNKHQSAVTCLQFN--KNFVITSSDDGTVKLWDLKTGEFIRNLV 661
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 160 bits (405), Expect = 1e-39
Identities = 96/299 (32%), Positives = 167/299 (55%), Gaps = 34/299 (11%)
Query: 37 LVGHTE-AVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSD- 94
L GH + ++ ++F G + S S D + +W A GK +TL GH + WSS
Sbjct: 296 LKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV----WSSQM 349
Query: 95 -SSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWE 153
+ ++S S D+TLK+W+ +G+C+ TL GH++ V C + + ++SGS D T+++W+
Sbjct: 350 RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVWD 407
Query: 154 VKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPV 213
++TG+CL L H V V ++ G +VSG+YD + ++WD + CL TL N
Sbjct: 408 IETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 465
Query: 214 SFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGG-----K 268
S ++F +G ++++ +LD ++++WD G C+ T TGH+ S+T G
Sbjct: 466 S-LQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQ----------SLTSGMELKDN 512
Query: 269 WIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAAC-HPTENLIASAALENDKTIKLW 326
+VSG+ D+ V IW+++T + +Q LQG + C +N + +++ +D T+KLW
Sbjct: 513 ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSS--DDGTVKLW 569
Score = 152 bits (384), Expect = 4e-37
Identities = 90/265 (33%), Positives = 144/265 (54%), Gaps = 21/265 (7%)
Query: 34 KC--TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAW 91
KC TLVGHT V S + N + S S DR + +W A G+ TLYGH +
Sbjct: 332 KCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVR--CM 387
Query: 92 SSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKI 151
R+VS S D TL++WD+ +G+CL L GH V C ++ ++SG++D VK+
Sbjct: 388 HLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKV 445
Query: 152 WEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNP 211
W+ +T CL TL H++ V ++ F+ G +VSGS D R+WD +G C+ TL +
Sbjct: 446 WDPETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSL 503
Query: 212 PVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTG---HKNEKYCIFANFSVTGGK 268
S ++ N +++ D+T+K+WD G+CL+T G H++ C+ N
Sbjct: 504 -TSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFN-----KN 555
Query: 269 WIVSGSEDNLVYIWNLQTKEIVQKL 293
++++ S+D V +W+L+T E ++ L
Sbjct: 556 FVITSSDDGTVKLWDLKTGEFIRNL 580
Score = 147 bits (372), Expect = 1e-35
Identities = 87/259 (33%), Positives = 136/259 (52%), Gaps = 17/259 (6%)
Query: 68 WGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNY 127
W + K K L GH+ + +R+VS SDD TLK+W +GKCL+TL GH+
Sbjct: 285 WRRGELKSPKVLKGHDDHVI-TCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG 343
Query: 128 VFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSY 187
V+ N+IISGS D T+K+W +TG+C+ TL H+ V +H + +VSGS
Sbjct: 344 VWSSQMR--DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH--EKRVVSGSR 399
Query: 188 DGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKT 247
D R+WD +GQCL L+ V V++ +G+ +++ D +K+WD CL T
Sbjct: 400 DATLRVWDIETGQCLHVLM-GHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHT 456
Query: 248 YTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHP 307
GH N Y + + G +VSGS D + +W+++T + L GH +++
Sbjct: 457 LQGHTNRVYSLQFD-----GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMEL 509
Query: 308 TENLIASAALENDKTIKLW 326
+N++ S D T+K+W
Sbjct: 510 KDNILVSG--NADSTVKIW 526
Score = 105 bits (261), Expect = 7e-23
Identities = 56/173 (32%), Positives = 96/173 (55%), Gaps = 11/173 (6%)
Query: 37 LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSS 96
L+GH AV V++ +G + S + D ++ +W TL GH + + + D
Sbjct: 417 LMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGI 472
Query: 97 RLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKT 156
+VS S D ++++WDV +G C+ TL GH + N+++SG+ D TVKIW++KT
Sbjct: 473 HVVSGSLDTSIRVWDVETGNCIHTLTGHQSLT--SGMELKDNILVSGNADSTVKIWDIKT 530
Query: 157 GKCLKTLSA---HSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLV 206
G+CL+TL H V+ + FN + +++ S DG ++WD +G+ ++ LV
Sbjct: 531 GQCLQTLQGPNKHQSAVTCLQFN--KNFVITSSDDGTVKLWDLKTGEFIRNLV 581
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 156 bits (394), Expect = 3e-38
Identities = 89/245 (36%), Positives = 136/245 (55%), Gaps = 6/245 (2%)
Query: 39 GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLY-GHNLEISDVAWSSDSSR 97
GH +AV+ V FSP+G LAS S D+ + IW + K E T++ H + V + SD
Sbjct: 21 GHKDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQS 79
Query: 98 LVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTG 157
V+ASDDKT+K+W K L +L H N+V C F+P LI+S S D+TVK+W+ +
Sbjct: 80 FVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 139
Query: 158 KCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVK 217
+C+ + H V+ V F+ SG+ I + D ++WD + + L+ + V+ +
Sbjct: 140 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH-YQLHSAAVNGLS 198
Query: 218 FSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDN 277
F P+G Y++TA+ D+TLK+ D GR L T GH+ + FS T G++ SG D
Sbjct: 199 FHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV--AFSRT-GEYFASGGSDE 255
Query: 278 LVYIW 282
V +W
Sbjct: 256 QVMVW 260
Score = 110 bits (275), Expect = 2e-24
Identities = 74/268 (27%), Positives = 123/268 (45%), Gaps = 6/268 (2%)
Query: 62 DRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTL 121
D +++W GH ++ V +S L S S DKT+++W
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
Query: 122 KGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSL 181
+ H+ V +F ++ S D+TVK+W K L +LS H + V F+ G L
Sbjct: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
Query: 182 IVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSR 241
IVS S D ++WD +S +C+ + + V++V F P+G I A +DNT+K+WD
Sbjct: 122 IVSASDDKTVKLWDKSSRECVHSYCEHGG-FVTYVDFHPSGTCIAAAGMDNTVKVWDVRT 180
Query: 242 GRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVI 301
R L+ Y H + + S G ++++ S D+ + I +L ++ L GH
Sbjct: 181 HRLLQHYQLHSAAVNGLSFHPS---GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 237
Query: 302 SAACHPTENLIASAALENDKTIKLWMSN 329
+ A T AS +D+ + +W SN
Sbjct: 238 TVAFSRTGEYFASGG--SDEQVMVWKSN 263
Score = 87.8 bits (216), Expect = 1e-17
Identities = 48/159 (30%), Positives = 81/159 (50%)
Query: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDS 95
+L H V KFSP+G + S+S D+ + +W + + H ++ V +
Sbjct: 102 SLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSG 161
Query: 96 SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVK 155
+ + +A D T+K+WDVR+ + L+ + HS V +F+P N +I+ S D T+KI ++
Sbjct: 162 TCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLM 221
Query: 156 TGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIW 194
G+ L TL H P + V F+ +G SG D +W
Sbjct: 222 EGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 260
Score = 61.6 bits (148), Expect = 9e-10
Identities = 34/142 (23%), Positives = 69/142 (48%)
Query: 12 QLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAY 71
+L +S+S +++ ++ + + + H V+ V F P+G +A++ D + +W
Sbjct: 120 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 179
Query: 72 DGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCC 131
+ + H+ ++ +++ + L++AS D TLK+ D+ G+ L TL GH
Sbjct: 180 THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV 239
Query: 132 NFNPPSNLIISGSFDETVKIWE 153
F+ SG DE V +W+
Sbjct: 240 AFSRTGEYFASGGSDEQVMVWK 261
Score = 44.7 bits (104), Expect = 1e-04
Identities = 30/101 (29%), Positives = 48/101 (47%), Gaps = 7/101 (6%)
Query: 230 LDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI 289
+D+ L +W +TGHK+ C+ NFS G + SGS D V IW K
Sbjct: 1 MDSCLMVWHMKPQSRAYRFTGHKDAVTCV--NFS-PSGHLLASGSRDKTVRIWVPNVKGE 57
Query: 290 VQKLQGHTDVVISA-ACHPTENLIASAALENDKTIKLWMSN 329
+ HT V S C ++ + ++ +DKT+K+W ++
Sbjct: 58 STVFRAHTATVRSVHFCSDGQSFVTAS---DDKTVKVWATH 95
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 156 bits (394), Expect = 3e-38
Identities = 89/245 (36%), Positives = 136/245 (55%), Gaps = 6/245 (2%)
Query: 39 GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLY-GHNLEISDVAWSSDSSR 97
GH +AV+ V FSP+G LAS S D+ + IW + K E T++ H + V + SD
Sbjct: 59 GHKDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQS 117
Query: 98 LVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTG 157
V+ASDDKT+K+W K L +L H N+V C F+P LI+S S D+TVK+W+ +
Sbjct: 118 FVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 177
Query: 158 KCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVK 217
+C+ + H V+ V F+ SG+ I + D ++WD + + L+ + V+ +
Sbjct: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY-QLHSAAVNGLS 236
Query: 218 FSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDN 277
F P+G Y++TA+ D+TLK+ D GR L T GH+ + FS T G++ SG D
Sbjct: 237 FHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV--AFSRT-GEYFASGGSDE 293
Query: 278 LVYIW 282
V +W
Sbjct: 294 QVMVW 298
Score = 130 bits (326), Expect = 2e-30
Identities = 80/256 (31%), Positives = 130/256 (50%), Gaps = 6/256 (2%)
Query: 70 AYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVF 129
A D E+ GH ++ V +S ++ +L S S D L +W ++ GH + V
Sbjct: 6 AEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVT 65
Query: 130 CCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDG 189
C NF+P +L+ SGS D+TV+IW AH+ V +VHF G V+ S D
Sbjct: 66 CVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK 125
Query: 190 LCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYT 249
++W + L +L N V KFSP+G+ I++A+ D T+KLWD S C+ +Y
Sbjct: 126 TVKVWATHRQKFLFSLSQHIN-WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC 184
Query: 250 GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTE 309
H + + +F G I + DN V +W+++T ++Q Q H+ V + HP+
Sbjct: 185 EHGG--FVTYVDFH-PSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSG 241
Query: 310 NLIASAALENDKTIKL 325
N + +A+ +D T+K+
Sbjct: 242 NYLITAS--SDSTLKI 255
Score = 87.8 bits (216), Expect = 1e-17
Identities = 48/159 (30%), Positives = 81/159 (50%)
Query: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDS 95
+L H V KFSP+G + S+S D+ + +W + + H ++ V +
Sbjct: 140 SLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSG 199
Query: 96 SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVK 155
+ + +A D T+K+WDVR+ + L+ + HS V +F+P N +I+ S D T+KI ++
Sbjct: 200 TCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLM 259
Query: 156 TGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIW 194
G+ L TL H P + V F+ +G SG D +W
Sbjct: 260 EGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 61.6 bits (148), Expect = 9e-10
Identities = 34/142 (23%), Positives = 69/142 (48%)
Query: 12 QLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAY 71
+L +S+S +++ ++ + + + H V+ V F P+G +A++ D + +W
Sbjct: 158 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217
Query: 72 DGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCC 131
+ + H+ ++ +++ + L++AS D TLK+ D+ G+ L TL GH
Sbjct: 218 THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV 277
Query: 132 NFNPPSNLIISGSFDETVKIWE 153
F+ SG DE V +W+
Sbjct: 278 AFSRTGEYFASGGSDEQVMVWK 299
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 156 bits (394), Expect = 3e-38
Identities = 89/245 (36%), Positives = 136/245 (55%), Gaps = 6/245 (2%)
Query: 39 GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLY-GHNLEISDVAWSSDSSR 97
GH +AV+ V FSP+G LAS S D+ + IW + K E T++ H + V + SD
Sbjct: 59 GHKDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQS 117
Query: 98 LVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTG 157
V+ASDDKT+K+W K L +L H N+V C F+P LI+S S D+TVK+W+ +
Sbjct: 118 FVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 177
Query: 158 KCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVK 217
+C+ + H V+ V F+ SG+ I + D ++WD + + L+ + V+ +
Sbjct: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY-QLHSAAVNGLS 236
Query: 218 FSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDN 277
F P+G Y++TA+ D+TLK+ D GR L T GH+ + FS T G++ SG D
Sbjct: 237 FHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV--AFSRT-GEYFASGGSDE 293
Query: 278 LVYIW 282
V +W
Sbjct: 294 QVMVW 298
Score = 130 bits (326), Expect = 2e-30
Identities = 80/256 (31%), Positives = 130/256 (50%), Gaps = 6/256 (2%)
Query: 70 AYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVF 129
A D E+ GH ++ V +S ++ +L S S D L +W ++ GH + V
Sbjct: 6 AEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVT 65
Query: 130 CCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDG 189
C NF+P +L+ SGS D+TV+IW AH+ V +VHF G V+ S D
Sbjct: 66 CVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK 125
Query: 190 LCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYT 249
++W + L +L N V KFSP+G+ I++A+ D T+KLWD S C+ +Y
Sbjct: 126 TVKVWATHRQKFLFSLSQHIN-WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC 184
Query: 250 GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTE 309
H + + +F G I + DN V +W+++T ++Q Q H+ V + HP+
Sbjct: 185 EHGG--FVTYVDFH-PSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSG 241
Query: 310 NLIASAALENDKTIKL 325
N + +A+ +D T+K+
Sbjct: 242 NYLITAS--SDSTLKI 255
Score = 87.8 bits (216), Expect = 1e-17
Identities = 48/159 (30%), Positives = 81/159 (50%)
Query: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDS 95
+L H V KFSP+G + S+S D+ + +W + + H ++ V +
Sbjct: 140 SLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSG 199
Query: 96 SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVK 155
+ + +A D T+K+WDVR+ + L+ + HS V +F+P N +I+ S D T+KI ++
Sbjct: 200 TCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLM 259
Query: 156 TGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIW 194
G+ L TL H P + V F+ +G SG D +W
Sbjct: 260 EGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 61.6 bits (148), Expect = 9e-10
Identities = 34/142 (23%), Positives = 69/142 (48%)
Query: 12 QLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAY 71
+L +S+S +++ ++ + + + H V+ V F P+G +A++ D + +W
Sbjct: 158 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217
Query: 72 DGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCC 131
+ + H+ ++ +++ + L++AS D TLK+ D+ G+ L TL GH
Sbjct: 218 THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV 277
Query: 132 NFNPPSNLIISGSFDETVKIWE 153
F+ SG DE V +W+
Sbjct: 278 AFSRTGEYFASGGSDEQVMVWK 299
>gi|153791298 mitogen-activated protein kinase organizer 1 [Homo
sapiens]
Length = 315
Score = 154 bits (389), Expect = 1e-37
Identities = 100/292 (34%), Positives = 153/292 (52%), Gaps = 9/292 (3%)
Query: 26 PENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLE 85
PE P LK TL AV +V+F+ +G + + +D+ + +W G +T GH E
Sbjct: 11 PELPQKRLK-TLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYE 69
Query: 86 ISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSF 145
+ D A S D+S L S DK + LWDV SG+ ++ +GH+ V FN + +I+SGS
Sbjct: 70 VLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSI 129
Query: 146 DETVKIWEVKTGK--CLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLK 203
D +++ W+ ++ + ++TL D VS+V S I++GS DG R +D GQ
Sbjct: 130 DSSIRCWDCRSRRPEPVQTLDEARDGVSSV--KVSDHEILAGSVDGRVRRYDLRMGQLFS 187
Query: 204 TLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFS 263
V P++ FS +G+ L ++LD+TL+L D G L Y GHKN++Y + S
Sbjct: 188 DYV---GSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLS 244
Query: 264 VTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASA 315
+VS SED V+ W+L + L + VV S A HPTE + +A
Sbjct: 245 -ERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLTA 295
Score = 68.6 bits (166), Expect = 8e-12
Identities = 42/125 (33%), Positives = 66/125 (52%), Gaps = 6/125 (4%)
Query: 202 LKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFAN 261
LKTL D V V+F+ +G Y LT D TLKLW+ RG L+TY+GH E +
Sbjct: 18 LKTL-DCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGS 76
Query: 262 FSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDK 321
F + + SG D V +W++ + ++V+K +GH V + + +I S ++ D
Sbjct: 77 FDNSS---LCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSI--DS 131
Query: 322 TIKLW 326
+I+ W
Sbjct: 132 SIRCW 136
>gi|14150114 mitogen-activated protein kinase organizer 1 [Homo
sapiens]
Length = 315
Score = 154 bits (389), Expect = 1e-37
Identities = 100/292 (34%), Positives = 153/292 (52%), Gaps = 9/292 (3%)
Query: 26 PENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLE 85
PE P LK TL AV +V+F+ +G + + +D+ + +W G +T GH E
Sbjct: 11 PELPQKRLK-TLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYE 69
Query: 86 ISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSF 145
+ D A S D+S L S DK + LWDV SG+ ++ +GH+ V FN + +I+SGS
Sbjct: 70 VLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSI 129
Query: 146 DETVKIWEVKTGK--CLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLK 203
D +++ W+ ++ + ++TL D VS+V S I++GS DG R +D GQ
Sbjct: 130 DSSIRCWDCRSRRPEPVQTLDEARDGVSSV--KVSDHEILAGSVDGRVRRYDLRMGQLFS 187
Query: 204 TLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFS 263
V P++ FS +G+ L ++LD+TL+L D G L Y GHKN++Y + S
Sbjct: 188 DYV---GSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLS 244
Query: 264 VTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASA 315
+VS SED V+ W+L + L + VV S A HPTE + +A
Sbjct: 245 -ERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLTA 295
Score = 68.6 bits (166), Expect = 8e-12
Identities = 42/125 (33%), Positives = 66/125 (52%), Gaps = 6/125 (4%)
Query: 202 LKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFAN 261
LKTL D V V+F+ +G Y LT D TLKLW+ RG L+TY+GH E +
Sbjct: 18 LKTL-DCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGS 76
Query: 262 FSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDK 321
F + + SG D V +W++ + ++V+K +GH V + + +I S ++ D
Sbjct: 77 FDNSS---LCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSI--DS 131
Query: 322 TIKLW 326
+I+ W
Sbjct: 132 SIRCW 136
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 150 bits (380), Expect = 1e-36
Identities = 86/253 (33%), Positives = 137/253 (54%), Gaps = 6/253 (2%)
Query: 38 VGHTEAVSSVKFSPNGEWLASSSADRLIIIW-GAYDGKYEKTLYGHNLEISDVAWSSDSS 96
VGH + V+SV+FSP+G LAS+S DR + +W GK+ + H + V +S+D
Sbjct: 57 VGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSE-FKAHTAPVRSVDFSADGQ 115
Query: 97 RLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKT 156
L +AS+DK++K+W + + L +L H+++V C F+P LI+S S D+T+KIW+
Sbjct: 116 FLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTN 175
Query: 157 GKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFV 216
+C+ S + V FN SG+ I S D ++WD + L+ + V+ +
Sbjct: 176 KQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQH-YQVHSGGVNCI 234
Query: 217 KFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSED 276
F P+G Y++TA+ D TLK+ D GR + T GH + + +FS GG+ SG D
Sbjct: 235 SFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTV--SFS-KGGELFASGGAD 291
Query: 277 NLVYIWNLQTKEI 289
V +W E+
Sbjct: 292 TQVLLWRTNFDEL 304
Score = 139 bits (351), Expect = 3e-33
Identities = 87/291 (29%), Positives = 141/291 (48%), Gaps = 6/291 (2%)
Query: 39 GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRL 98
GH A++S+ SPNG+ LA++S D +++W GH ++ V +S + L
Sbjct: 16 GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLL 75
Query: 99 VSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGK 158
SAS D+T++LW K H+ V +F+ + + S D+++K+W + +
Sbjct: 76 ASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQR 135
Query: 159 CLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKF 218
L +L H+ V F+ G LIVS S D +IWD + QC+ D +FV F
Sbjct: 136 FLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNF-SDSVGFANFVDF 194
Query: 219 SPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 278
+P+G I +A D T+K+WD + L+ Y H CI + S G ++++ S D
Sbjct: 195 NPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPS---GNYLITASSDGT 251
Query: 279 VYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLWMSN 329
+ I +L ++ LQGHT V + + L AS D + LW +N
Sbjct: 252 LKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGA--DTQVLLWRTN 300
Score = 114 bits (286), Expect = 9e-26
Identities = 73/255 (28%), Positives = 128/255 (50%), Gaps = 8/255 (3%)
Query: 72 DGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCC 131
D E+ GH I+ + S + +L +AS D L LW+ + GH + V
Sbjct: 7 DPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSV 66
Query: 132 NFNPPSNLIISGSFDETVKIW-EVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGL 190
F+P NL+ S S D TV++W K GK AH+ PV +V F+ G + + S D
Sbjct: 67 QFSPHGNLLASASRDRTVRLWIPDKRGK-FSEFKAHTAPVRSVDFSADGQFLATASEDKS 125
Query: 191 CRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTG 250
++W + L +L + V KFSP+G+ I++ + D T+K+WD + +C+ ++
Sbjct: 126 IKVWSMYRQRFLYSLYRHTH-WVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFS- 183
Query: 251 HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTEN 310
+ + F +F+ G I S D V +W+++ +++Q Q H+ V + HP+ N
Sbjct: 184 -DSVGFANFVDFN-PSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGN 241
Query: 311 LIASAALENDKTIKL 325
+ +A+ +D T+K+
Sbjct: 242 YLITAS--SDGTLKI 254
Score = 98.2 bits (243), Expect = 9e-21
Identities = 59/186 (31%), Positives = 92/186 (49%)
Query: 9 AKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIW 68
A Q ++S ++S +V +L HT V KFSP+G + S S D+ I IW
Sbjct: 112 ADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIW 171
Query: 69 GAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYV 128
+ + + V ++ + + SA D+T+K+WDVR K L+ + HS V
Sbjct: 172 DTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGV 231
Query: 129 FCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYD 188
C +F+P N +I+ S D T+KI ++ G+ + TL H+ PV V F+ G L SG D
Sbjct: 232 NCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGAD 291
Query: 189 GLCRIW 194
+W
Sbjct: 292 TQVLLW 297
Score = 37.0 bits (84), Expect = 0.024
Identities = 21/51 (41%), Positives = 28/51 (54%), Gaps = 1/51 (1%)
Query: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGA-YDGKYEKTLYGHNLE 85
TL GHT V +V FS GE AS AD +++W +D + K L NL+
Sbjct: 265 TLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELHCKGLTKRNLK 315
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 144 bits (364), Expect = 8e-35
Identities = 85/291 (29%), Positives = 147/291 (50%), Gaps = 17/291 (5%)
Query: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDS 95
T + + +++V + + +A AD + +W K + V +SD
Sbjct: 465 TFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKK-----------LRSVKQASDL 513
Query: 96 SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVK 155
S + SDD ++ D ++ LK L GHS V+ +F+P N ++S S D TV++W ++
Sbjct: 514 SLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQ 573
Query: 156 TGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSF 215
T CL H+ PV F+ G VSG +D + R+W Q L+ + V+
Sbjct: 574 TFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLR-IFAGHLADVNC 632
Query: 216 VKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSE 275
+F PN Y+ T + D T++LWD G C++ +TGHK + + FS G+++ +G+
Sbjct: 633 TRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSL--TFS-PNGRFLATGAT 689
Query: 276 DNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
D V +W++ +V +L+GHTD V S ++AS +++N T++LW
Sbjct: 690 DGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDN--TVRLW 738
Score = 119 bits (299), Expect = 3e-27
Identities = 69/238 (28%), Positives = 118/238 (49%), Gaps = 4/238 (1%)
Query: 46 SVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDK 105
SVK + + + S D L I K LYGH+ + ++S D + L+S+S+D
Sbjct: 506 SVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDG 565
Query: 106 TLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSA 165
T++LW +++ CL KGH+ V+ F+P +SG D ++W + L+ +
Sbjct: 566 TVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAG 625
Query: 166 HSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYI 225
H V+ F+ + + + +GS D R+WD +G C++ + P+ + FSPNG+++
Sbjct: 626 HLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVR-IFTGHKGPIHSLTFSPNGRFL 684
Query: 226 LTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN 283
T D + LWD G + GH + + FS G+ + SGS DN V +W+
Sbjct: 685 ATGATDGRVLLWDIGHGLMVGELKGHTDTVCSL--RFS-RDGEILASGSMDNTVRLWD 739
Score = 103 bits (256), Expect = 3e-22
Identities = 53/192 (27%), Positives = 94/192 (48%), Gaps = 3/192 (1%)
Query: 39 GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRL 98
GH V +FSP G + S DR+ +W + + GH +++ + +S+ +
Sbjct: 583 GHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYV 642
Query: 99 VSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGK 158
+ S D+T++LWDV +G C++ GH + F+P + +G+ D V +W++ G
Sbjct: 643 ATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGL 702
Query: 159 CLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASG-QCLKTLVDDDNPPVSFVK 217
+ L H+D V ++ F+ G ++ SGS D R+WDA + L+T DD +
Sbjct: 703 MVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLET--DDFTTATGHIN 760
Query: 218 FSPNGKYILTAT 229
N + +L T
Sbjct: 761 LPENSQELLLGT 772
Score = 79.7 bits (195), Expect = 3e-15
Identities = 47/173 (27%), Positives = 77/173 (44%), Gaps = 24/173 (13%)
Query: 39 GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRL 98
GH V+ +F PN ++A+ SADR + +W +G + GH I + +S + L
Sbjct: 625 GHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFL 684
Query: 99 VSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEV---- 154
+ + D + LWD+ G + LKGH++ V F+ ++ SGS D TV++W+
Sbjct: 685 ATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAF 744
Query: 155 ----------KTGKC----------LKTLSAHSDPVSAVHFNCSGSLIVSGSY 187
TG L T S PV +HF ++ +G+Y
Sbjct: 745 EDLETDDFTTATGHINLPENSQELLLGTYMTKSTPVVHLHFTRRNLVLAAGAY 797
Score = 66.2 bits (160), Expect = 4e-11
Identities = 49/198 (24%), Positives = 78/198 (39%), Gaps = 35/198 (17%)
Query: 159 CLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIW-------------------DAASG 199
C T ++AV SLI G D R+W D S
Sbjct: 462 CFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESD 521
Query: 200 QCLKTLVDD-----------DNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTY 248
L+ ++D+ + PV FSP+ Y+L+++ D T++LW CL Y
Sbjct: 522 DVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGY 581
Query: 249 TGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPT 308
GH Y ++ G + VSG D + +W + ++ GH V HP
Sbjct: 582 KGH---NYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPN 638
Query: 309 ENLIASAALENDKTIKLW 326
N +A+ + D+T++LW
Sbjct: 639 SNYVATGSA--DRTVRLW 654
Score = 37.7 bits (86), Expect = 0.014
Identities = 17/34 (50%), Positives = 23/34 (67%)
Query: 37 LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGA 70
L GHT+ V S++FS +GE LAS S D + +W A
Sbjct: 707 LKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDA 740
>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
sapiens]
Length = 513
Score = 138 bits (347), Expect = 8e-33
Identities = 90/303 (29%), Positives = 148/303 (48%), Gaps = 18/303 (5%)
Query: 39 GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGH---NLEISDVA----- 90
G V +FSP+G++L + S D I +W GK K L N + D A
Sbjct: 212 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMC 271
Query: 91 WSSDSSRLVSASDDKTLKLWDVRSGKCLKTL-KGHSNYVFCCNFNPPSNLIISGSFDETV 149
+S D+ L + + D +K+W ++SG+CL+ + HS V C +F+ S+ I+S SFD+T+
Sbjct: 272 FSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTI 331
Query: 150 KIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTL---- 205
+I +K+GK LK HS V+ F G I+S S DG +IW+ + +C T
Sbjct: 332 RIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLG 391
Query: 206 --VDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFS 263
D S + N ++ + NT+ + + +G+ +++++ K E
Sbjct: 392 STAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNM-QGQIVRSFSSGKREGGDFVCCAL 450
Query: 264 VTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTI 323
G+WI ED ++Y ++ T ++ + L H VI A HP +NLIA+ D +
Sbjct: 451 SPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIAT--YSEDGLL 508
Query: 324 KLW 326
KLW
Sbjct: 509 KLW 511
Score = 28.5 bits (62), Expect = 8.6
Identities = 16/51 (31%), Positives = 25/51 (49%)
Query: 103 DDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWE 153
+D L + +GK +TL H V +P NLI + S D +K+W+
Sbjct: 462 EDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWK 512
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 137 bits (346), Expect = 1e-32
Identities = 84/302 (27%), Positives = 145/302 (48%), Gaps = 13/302 (4%)
Query: 35 CTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSD 94
C+ +G +S FSPN + LA++ L +W D TL GHN + + +
Sbjct: 225 CSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPK 284
Query: 95 SS--------RLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFD 146
S+ L S + D ++KLW + S + + ++GH+ V ++P + + +D
Sbjct: 285 STVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYD 344
Query: 147 ETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLV 206
+ ++W+++ + + HS V + F+ GSL +G D R+WD +G+C+ L
Sbjct: 345 RSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFL- 403
Query: 207 DDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTG 266
+ + + FSPNG +I T + DNT K+WD + RC+ T H+N F
Sbjct: 404 EGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQN--LVTGVKFEPIH 461
Query: 267 GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
G ++++G+ DN IW ++ L GH V+ LIA+ + D+T KLW
Sbjct: 462 GNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSY--DRTFKLW 519
Query: 327 MS 328
M+
Sbjct: 520 MA 521
Score = 122 bits (305), Expect = 6e-28
Identities = 73/263 (27%), Positives = 128/263 (48%), Gaps = 13/263 (4%)
Query: 29 PNYALKCTLVGHTEAVSSVKFSPNGEW--------LASSSADRLIIIWGAYDGKYEKTLY 80
P+ L TL GH V ++ F P LAS +AD + +W + +
Sbjct: 261 PDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIE 320
Query: 81 GHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLI 140
GH + ++ V W L + D++ +LWD+ + + + +GHS V+ F+ +L
Sbjct: 321 GHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLA 380
Query: 141 ISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQ 200
+G D ++W+++TG+C+ L H + ++F+ +G I +GS D C++WD +
Sbjct: 381 GTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRR 440
Query: 201 CLKTLVDDDNPPVSFVKFSP-NGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIF 259
C+ T+ N V+ VKF P +G ++LT DNT K+W + LKT GH+ + +
Sbjct: 441 CVYTIPAHQN-LVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGK---VM 496
Query: 260 ANFSVTGGKWIVSGSEDNLVYIW 282
+ G+ I + S D +W
Sbjct: 497 GLDISSDGQLIATCSYDRTFKLW 519
Score = 30.8 bits (68), Expect = 1.7
Identities = 15/56 (26%), Positives = 30/56 (53%)
Query: 15 LSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGA 70
L+ + + + ++ +P ++ TL GH V + S +G+ +A+ S DR +W A
Sbjct: 466 LTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMA 521
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 137 bits (344), Expect = 2e-32
Identities = 89/330 (26%), Positives = 160/330 (48%), Gaps = 16/330 (4%)
Query: 5 ESRDAKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRL 64
E+ + K ++ A + +P + L + GH V + P +W + SADR
Sbjct: 168 ETGNTKNSALMAKKAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRT 227
Query: 65 IIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGH 124
I IW GK + +L GH + V S+ S L S +DK +K WD+ K ++ GH
Sbjct: 228 IKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGH 287
Query: 125 SNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVS 184
+ V+ + +P +++++ S D T +IW+V+T + TLS H++ V+ V + I++
Sbjct: 288 LSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIIT 347
Query: 185 GSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRC 244
GS+D R+WD +G+ TL + V V P + + DN +K W + G
Sbjct: 348 GSHDTTIRLWDLVAGKTRVTLT-NHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSF 405
Query: 245 LKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ-----GHTDV 299
++ +GH I +V +VSG+++ +++W+ +T Q++ G D
Sbjct: 406 IQNLSGHN----AIINTLTVNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDS 461
Query: 300 ---VISAACHPTENLIASAALENDKTIKLW 326
+ + A +E+ + +A E DKTIK++
Sbjct: 462 ESGIFACAFDQSESRLLTA--EADKTIKVY 489
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 134 bits (336), Expect = 1e-31
Identities = 85/247 (34%), Positives = 130/247 (52%), Gaps = 16/247 (6%)
Query: 37 LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSS 96
L GHT V +FSP+G AS+S D + +W K + L GH + V++S DS
Sbjct: 59 LGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSR 118
Query: 97 RLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWE--- 153
+L S DK + LWDV+SG+ L+ L GH + + +F+P N + +GS+D TV IW+
Sbjct: 119 QLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRM 178
Query: 154 VKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPV 213
V + L HS +S + ++ SG L+ SGS+D IW + L L V
Sbjct: 179 VTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQL----KGHV 233
Query: 214 SFVK---FSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKY-CIFANFSVTGGKW 269
++VK FSP+ ++ +A +K+WD + G+CL+T G + + C F GK
Sbjct: 234 TWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAF----TPDGKI 289
Query: 270 IVSGSED 276
+VSG+ D
Sbjct: 290 LVSGAAD 296
Score = 132 bits (332), Expect = 4e-31
Identities = 83/289 (28%), Positives = 140/289 (48%), Gaps = 16/289 (5%)
Query: 40 HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLV 99
H V+S FSP+G+ L + S D + W G+ L GH + +S D
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 100 SASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKC 159
SAS D T++LWDV KCL+ LKGH V +F+P S + SG +D+ V +W+V++G+
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
Query: 160 LKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD------AASGQCLKTLVDDDNPPV 213
L+ L H D + + F+ + + + +GS+D IWD A S Q L + + +
Sbjct: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQAL----EGHSANI 195
Query: 214 SFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKN-EKYCIFANFSVTGGKWIVS 272
S + +S +G + + + D T+ +W + L GH K F+ + W+ S
Sbjct: 196 SCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDEL----WLAS 250
Query: 273 GSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDK 321
+V +W+ T + ++ L+G DV + A P ++ S A + +
Sbjct: 251 AGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTR 299
Score = 95.5 bits (236), Expect = 6e-20
Identities = 53/167 (31%), Positives = 91/167 (54%), Gaps = 6/167 (3%)
Query: 160 LKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFS 219
+K H V++ F+ G ++++GS DG W+ SGQ L L PV F +FS
Sbjct: 14 VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRL-GGHTGPVKFCRFS 72
Query: 220 PNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLV 279
P+G +A+ D T++LWD +R +CL+ GH+ + +FS + + SG D V
Sbjct: 73 PDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETV--SFS-PDSRQLASGGWDKRV 129
Query: 280 YIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
+W++Q+ ++++ L GH D + S+ PT N +A+ + D T+ +W
Sbjct: 130 MLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSW--DSTVHIW 174
Score = 47.8 bits (112), Expect = 1e-05
Identities = 30/94 (31%), Positives = 47/94 (50%)
Query: 13 LALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYD 72
L S S +++ + + +L L GH V S+ FSP+ WLAS+ R++ +W
Sbjct: 205 LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNT 264
Query: 73 GKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKT 106
GK +TL G A++ D LVS + D+T
Sbjct: 265 GKCLETLKGVLDVAHTCAFTPDGKILVSGAADQT 298
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 130 bits (326), Expect = 2e-30
Identities = 91/348 (26%), Positives = 156/348 (44%), Gaps = 58/348 (16%)
Query: 27 ENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYE-KTLYGHNLE 85
E P++ K GH V S+ +SP+G LAS + I++W GK +TL GH+
Sbjct: 146 ETPHFTCK----GHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKW 201
Query: 86 ISDVAW-----SSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLI 140
I+ ++W + + + S+S D ++++WD +G+C + L GH+ V C + L+
Sbjct: 202 ITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGG-DGLL 260
Query: 141 ISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCS---------------------G 179
S S D T+K+W G +TL H V+ + + G
Sbjct: 261 YSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQG 320
Query: 180 SL---------------------IVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKF 218
SL +VSGS D +W A + T + ++ V F
Sbjct: 321 SLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLF 380
Query: 219 SPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 278
SP+ + + +A+ D ++KLWD G+ L + GH Y I + + +VSGS D+
Sbjct: 381 SPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWS---ADSRLLVSGSSDST 437
Query: 279 VYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
+ +W+++ +++ L GH D V + P +AS DK +++W
Sbjct: 438 LKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGG--KDKCLRIW 483
Score = 123 bits (309), Expect = 2e-28
Identities = 89/311 (28%), Positives = 150/311 (48%), Gaps = 34/311 (10%)
Query: 34 KCT--LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAW 91
+CT L GH+EAV SV FSP G++LAS S D + W T GH + ++W
Sbjct: 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISW 164
Query: 92 SSDSSRLVSASDDKTLKLWDVRSGKCL-KTLKGHSNYVFCCNF-----NPPSNLIISGSF 145
S D +L S + + LWD +GK + +TL GHS ++ ++ NP + S S
Sbjct: 165 SPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSK 224
Query: 146 DETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTL 205
D +V+IW+ G+C + L+ H+ V+ + + G L+ S S D ++W A G +TL
Sbjct: 225 DGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTL 283
Query: 206 VDDDNPPVSFVKFSPNGKYILTATL--DNTLKLWDYSRGRCL---KTYTGHKNE-KYCIF 259
+G ++ T L D L+ + + G E K
Sbjct: 284 -------------QGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERAL 330
Query: 260 ANFSVTGGKW---IVSGSEDNLVYIWN-LQTKEIVQKLQGHTDVVISAACHPTENLIASA 315
+ +++ G+ +VSGS+D +++W+ + K+ + ++ GH ++ P ++ASA
Sbjct: 331 SRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASA 390
Query: 316 ALENDKTIKLW 326
+ DK+IKLW
Sbjct: 391 SF--DKSIKLW 399
Score = 106 bits (264), Expect = 3e-23
Identities = 76/265 (28%), Positives = 122/265 (46%), Gaps = 45/265 (16%)
Query: 16 SSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKY 75
SSS + S + + + L GHT++V+ +++ +G L S+S DR I +W A+DG
Sbjct: 221 SSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVL 279
Query: 76 EKTLYGHNLEISDVAWSSDSS--------------------------------------- 96
+TL GH ++ +A S+D +
Sbjct: 280 CRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQ 339
Query: 97 ---RLVSASDDKTLKLWD-VRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW 152
RLVS SDD TL LW K L + GH + F+P S ++ S SFD+++K+W
Sbjct: 340 GPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLW 399
Query: 153 EVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPP 212
+ +TGK L +L H V + ++ L+VSGS D ++WD Q L +
Sbjct: 400 DGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWD-VKAQKLAMDLPGHADE 458
Query: 213 VSFVKFSPNGKYILTATLDNTLKLW 237
V V +SP+G+ + + D L++W
Sbjct: 459 VYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 63.2 bits (152), Expect = 3e-10
Identities = 50/184 (27%), Positives = 85/184 (46%), Gaps = 25/184 (13%)
Query: 158 KCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVK 217
+C +L HS+ V +V F+ +G + SGS D R WD ++ T + +S +
Sbjct: 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLS-IS 163
Query: 218 FSPNGKYILTATLDNTLKLWDYSRGRCL-KTYTGHKNEKYCIFANFSVTGGKW------- 269
+SP+G+ + + + + LWD S G+ + +T GH +TG W
Sbjct: 164 WSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKW---------ITGLSWEPLHANP 214
Query: 270 ----IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKL 325
+ S S+D V IW+ + L GHT V + + L+ SA+ D+TIK+
Sbjct: 215 ECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSV-TCLRWGGDGLLYSAS--QDRTIKV 271
Query: 326 WMSN 329
W ++
Sbjct: 272 WRAH 275
Score = 53.5 bits (127), Expect = 3e-07
Identities = 29/100 (29%), Positives = 49/100 (49%)
Query: 11 AQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGA 70
+++ S+S ++S ++ + +L GH AV + +S + L S S+D + +W
Sbjct: 384 SRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDV 443
Query: 71 YDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLW 110
K L GH E+ V WS D R+ S DK L++W
Sbjct: 444 KAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 37.0 bits (84), Expect = 0.024
Identities = 19/60 (31%), Positives = 35/60 (58%)
Query: 9 AKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIW 68
A ++L +S S++ + +V + L L GH + V +V +SP+G+ +AS D+ + IW
Sbjct: 424 ADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 129 bits (323), Expect = 5e-30
Identities = 91/310 (29%), Positives = 148/310 (47%), Gaps = 11/310 (3%)
Query: 20 NQSKEV--PENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEK 77
N SKE P +Y LK H VS V P+ + L S DRL + G
Sbjct: 329 NVSKESLSPAKFDYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLL 388
Query: 78 TLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPS 137
T +GH +SD + +L ++S D T+KLWD+ G C+ T +GHS V+ C ++
Sbjct: 389 TGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCG 448
Query: 138 NLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAA 197
N + S S D+T KIW+V + +C TL H+D V+++ F + +++ S D IWDA
Sbjct: 449 NFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDAR 508
Query: 198 SGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYC 257
+G C ++L + ++ F P G I + KLWD+ + L +
Sbjct: 509 TGICEQSLYGHMH-SINDAIFDPRGHMIASCDACGVTKLWDFR--KLLPIVSIDIGPSPG 565
Query: 258 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAA-CHPTENLIASAA 316
NF + G+ + S + ++++ +L++ EI KL GH + + H E L +
Sbjct: 566 NEVNFD-SSGRVLAQASGNGVIHLLDLKSGEI-HKLMGHENEAHTVVFSHDGEILFSGG- 622
Query: 317 LENDKTIKLW 326
+D T++ W
Sbjct: 623 --SDGTVRTW 630
Score = 88.6 bits (218), Expect = 7e-18
Identities = 52/179 (29%), Positives = 91/179 (50%), Gaps = 1/179 (0%)
Query: 16 SSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKY 75
SSS +++ ++ + + +CTL GHT++V+S++F P L +SSAD+ + IW A G
Sbjct: 453 SSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGIC 512
Query: 76 EKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNP 135
E++LYGH I+D + + S KLWD R + ++ + NF+
Sbjct: 513 EQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDS 572
Query: 136 PSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIW 194
++ S + + + ++K+G+ K L H + V F+ G ++ SG DG R W
Sbjct: 573 SGRVLAQASGNGVIHLLDLKSGEIHK-LMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
Score = 52.4 bits (124), Expect = 6e-07
Identities = 38/143 (26%), Positives = 68/143 (47%), Gaps = 11/143 (7%)
Query: 15 LSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGK 74
L+SSA+++ + + + +L GH +++ F P G +AS A + +W
Sbjct: 494 LTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLW-----D 548
Query: 75 YEKTLYGHNLEI-----SDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVF 129
+ K L +++I ++V + S L AS + + L D++SG+ K L GH N
Sbjct: 549 FRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEIHK-LMGHENEAH 607
Query: 130 CCNFNPPSNLIISGSFDETVKIW 152
F+ ++ SG D TV+ W
Sbjct: 608 TVVFSHDGEILFSGGSDGTVRTW 630
>gi|7706657 cell division cycle 40 homolog [Homo sapiens]
Length = 579
Score = 126 bits (316), Expect = 3e-29
Identities = 82/298 (27%), Positives = 145/298 (48%), Gaps = 15/298 (5%)
Query: 39 GHTEAVSSVKFSP-NGEWLASSSADRLIIIWGAY-DGKYEKTLYGHNLEISDVAWSSDSS 96
GHT+ VS+V+ P +G L S S D I +W Y + + +T GH+ + D+ +++ +
Sbjct: 286 GHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGT 345
Query: 97 RLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPS---NLIISGSFDETVKIWE 153
+ +SA+ D+ LKLWD +G+C+ +C FNP NL ++G D+ + W+
Sbjct: 346 QFLSAAYDRYLKLWDTETGQCISRFTNRK-VPYCVKFNPDEDKQNLFVAGMSDKKIVQWD 404
Query: 154 VKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPV 213
+++G+ ++ H V+ + F VS S D R+W+ K + + +
Sbjct: 405 IRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSM 464
Query: 214 SFVKFSPNGKYILTATLDNTLKLW---DYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWI 270
V SPNGK++ ++DN + ++ + R K + GH Y +FS ++
Sbjct: 465 PAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFS-PDMSYV 523
Query: 271 VSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHP--TENLIASAALENDKTIKLW 326
+SG + + IW+ +T ++ + + H V I A HP T +I D IKLW
Sbjct: 524 ISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGW---DGLIKLW 578
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 126 bits (316), Expect = 3e-29
Identities = 78/236 (33%), Positives = 128/236 (54%), Gaps = 19/236 (8%)
Query: 94 DSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWE 153
D +++S D ++K+WD S +CLK L GH+ V C ++ +I++GS D TV++W+
Sbjct: 249 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYD--ERVIVTGSSDSTVRVWD 306
Query: 154 VKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQ--CLKTLVDDDNP 211
V TG+ L TL H++ V +H S L+V+ S D +WD AS L+ ++
Sbjct: 307 VNTGEVLNTLIHHNEAV--LHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRA 364
Query: 212 PVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIV 271
V+ V F + KYI++A+ D T+K+W S ++T GHK C+ + +V
Sbjct: 365 AVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR-----DRLVV 417
Query: 272 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTEN-LIASAALENDKTIKLW 326
SGS DN + +W+++ ++ L+GH ++V C +N I S A D IK+W
Sbjct: 418 SGSSDNTIRLWDIECGACLRVLEGHEELV---RCIRFDNKRIVSGAY--DGKIKVW 468
Score = 119 bits (297), Expect = 5e-27
Identities = 72/218 (33%), Positives = 119/218 (54%), Gaps = 27/218 (12%)
Query: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIW---GAYDGKYEKTLYGHNLEISDVAWS 92
TL+ H EAV ++FS NG + + S DR I +W A D + L GH ++ V +
Sbjct: 315 TLIHHNEAVLHLRFS-NG-LMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF- 371
Query: 93 SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW 152
D +VSAS D+T+K+W + + ++TL GH + C + L++SGS D T+++W
Sbjct: 372 -DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLW 428
Query: 153 EVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD---------AASGQCLK 203
+++ G CL+ L H + V + F+ IVSG+YDG ++WD AS CL+
Sbjct: 429 DIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLR 486
Query: 204 TLVDDDNP--PVSFVKFSPNGKYILTATLDNTLKLWDY 239
TLV+ + F +F I++++ D+T+ +WD+
Sbjct: 487 TLVEHSGRVFRLQFDEFQ-----IISSSHDDTILIWDF 519
Score = 99.0 bits (245), Expect = 5e-21
Identities = 58/172 (33%), Positives = 93/172 (54%), Gaps = 17/172 (9%)
Query: 33 LKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWS 92
L+ LVGH AV+ V F + +++ S+S DR I +W ++ +TL GH I+ + +
Sbjct: 355 LRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR 412
Query: 93 SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW 152
+VS S D T++LWD+ G CL+ L+GH V C F+ + I+SG++D +K+W
Sbjct: 413 D--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVW 468
Query: 153 EVKTG---------KCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195
+++ CL+TL HS V + F+ I+S S+D IWD
Sbjct: 469 DLQAALDPRAPASTLCLRTLVEHSGRVFRLQFD--EFQIISSSHDDTILIWD 518
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 126 bits (316), Expect = 3e-29
Identities = 78/236 (33%), Positives = 128/236 (54%), Gaps = 19/236 (8%)
Query: 94 DSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWE 153
D +++S D ++K+WD S +CLK L GH+ V C ++ +I++GS D TV++W+
Sbjct: 215 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYD--ERVIVTGSSDSTVRVWD 272
Query: 154 VKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQ--CLKTLVDDDNP 211
V TG+ L TL H++ V +H S L+V+ S D +WD AS L+ ++
Sbjct: 273 VNTGEVLNTLIHHNEAV--LHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRA 330
Query: 212 PVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIV 271
V+ V F + KYI++A+ D T+K+W S ++T GHK C+ + +V
Sbjct: 331 AVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR-----DRLVV 383
Query: 272 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTEN-LIASAALENDKTIKLW 326
SGS DN + +W+++ ++ L+GH ++V C +N I S A D IK+W
Sbjct: 384 SGSSDNTIRLWDIECGACLRVLEGHEELV---RCIRFDNKRIVSGAY--DGKIKVW 434
Score = 119 bits (297), Expect = 5e-27
Identities = 72/218 (33%), Positives = 119/218 (54%), Gaps = 27/218 (12%)
Query: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIW---GAYDGKYEKTLYGHNLEISDVAWS 92
TL+ H EAV ++FS NG + + S DR I +W A D + L GH ++ V +
Sbjct: 281 TLIHHNEAVLHLRFS-NG-LMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF- 337
Query: 93 SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW 152
D +VSAS D+T+K+W + + ++TL GH + C + L++SGS D T+++W
Sbjct: 338 -DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLW 394
Query: 153 EVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD---------AASGQCLK 203
+++ G CL+ L H + V + F+ IVSG+YDG ++WD AS CL+
Sbjct: 395 DIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLR 452
Query: 204 TLVDDDNP--PVSFVKFSPNGKYILTATLDNTLKLWDY 239
TLV+ + F +F I++++ D+T+ +WD+
Sbjct: 453 TLVEHSGRVFRLQFDEFQ-----IISSSHDDTILIWDF 485
Score = 99.0 bits (245), Expect = 5e-21
Identities = 58/172 (33%), Positives = 93/172 (54%), Gaps = 17/172 (9%)
Query: 33 LKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWS 92
L+ LVGH AV+ V F + +++ S+S DR I +W ++ +TL GH I+ + +
Sbjct: 321 LRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR 378
Query: 93 SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW 152
+VS S D T++LWD+ G CL+ L+GH V C F+ + I+SG++D +K+W
Sbjct: 379 D--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVW 434
Query: 153 EVKTG---------KCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195
+++ CL+TL HS V + F+ I+S S+D IWD
Sbjct: 435 DLQAALDPRAPASTLCLRTLVEHSGRVFRLQFD--EFQIISSSHDDTILIWD 484
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 126 bits (316), Expect = 3e-29
Identities = 78/236 (33%), Positives = 128/236 (54%), Gaps = 19/236 (8%)
Query: 94 DSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWE 153
D +++S D ++K+WD S +CLK L GH+ V C ++ +I++GS D TV++W+
Sbjct: 236 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYD--ERVIVTGSSDSTVRVWD 293
Query: 154 VKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQ--CLKTLVDDDNP 211
V TG+ L TL H++ V +H S L+V+ S D +WD AS L+ ++
Sbjct: 294 VNTGEVLNTLIHHNEAV--LHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRA 351
Query: 212 PVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIV 271
V+ V F + KYI++A+ D T+K+W S ++T GHK C+ + +V
Sbjct: 352 AVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR-----DRLVV 404
Query: 272 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTEN-LIASAALENDKTIKLW 326
SGS DN + +W+++ ++ L+GH ++V C +N I S A D IK+W
Sbjct: 405 SGSSDNTIRLWDIECGACLRVLEGHEELV---RCIRFDNKRIVSGAY--DGKIKVW 455
Score = 119 bits (297), Expect = 5e-27
Identities = 72/218 (33%), Positives = 119/218 (54%), Gaps = 27/218 (12%)
Query: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIW---GAYDGKYEKTLYGHNLEISDVAWS 92
TL+ H EAV ++FS NG + + S DR I +W A D + L GH ++ V +
Sbjct: 302 TLIHHNEAVLHLRFS-NG-LMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF- 358
Query: 93 SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW 152
D +VSAS D+T+K+W + + ++TL GH + C + L++SGS D T+++W
Sbjct: 359 -DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLW 415
Query: 153 EVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD---------AASGQCLK 203
+++ G CL+ L H + V + F+ IVSG+YDG ++WD AS CL+
Sbjct: 416 DIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLR 473
Query: 204 TLVDDDNP--PVSFVKFSPNGKYILTATLDNTLKLWDY 239
TLV+ + F +F I++++ D+T+ +WD+
Sbjct: 474 TLVEHSGRVFRLQFDEFQ-----IISSSHDDTILIWDF 506
Score = 99.0 bits (245), Expect = 5e-21
Identities = 58/172 (33%), Positives = 93/172 (54%), Gaps = 17/172 (9%)
Query: 33 LKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWS 92
L+ LVGH AV+ V F + +++ S+S DR I +W ++ +TL GH I+ + +
Sbjct: 342 LRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR 399
Query: 93 SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW 152
+VS S D T++LWD+ G CL+ L+GH V C F+ + I+SG++D +K+W
Sbjct: 400 D--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVW 455
Query: 153 EVKTG---------KCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195
+++ CL+TL HS V + F+ I+S S+D IWD
Sbjct: 456 DLQAALDPRAPASTLCLRTLVEHSGRVFRLQFD--EFQIISSSHDDTILIWD 505
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 124 bits (312), Expect = 9e-29
Identities = 66/227 (29%), Positives = 117/227 (51%), Gaps = 11/227 (4%)
Query: 33 LKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWS 92
L TL H + ++K++ G ++ S+ D+ IIW A+ G+ ++ H+ DV W
Sbjct: 258 LASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ 317
Query: 93 SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW 152
S+++ S S D + + + + +KT +GH+N V ++P NL+ S S D T+KIW
Sbjct: 318 SNNT-FASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIW 376
Query: 153 EVKTGKCLKTLSAHSDPVSAVHFNCSGS---------LIVSGSYDGLCRIWDAASGQCLK 203
+K C+ L AH+ + + ++ +G ++ S S+D R+WD G C+
Sbjct: 377 SMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIH 436
Query: 204 TLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTG 250
TL P S V FSP+G+Y+ + + D + +W+ G + +Y G
Sbjct: 437 TLTKHQEPVYS-VAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRG 482
Score = 119 bits (297), Expect = 5e-27
Identities = 75/261 (28%), Positives = 128/261 (49%), Gaps = 15/261 (5%)
Query: 44 VSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASD 103
V+S+ ++ G LA+ S D IW DG TL H I + W+ + ++SA
Sbjct: 228 VTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGV 286
Query: 104 DKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTL 163
DKT +WD +G+ + HS ++ +N S S D + + ++ + +KT
Sbjct: 287 DKTTIIWDAHTGEAKQQFPFHSAPALDVDWQS-NNTFASCSTDMCIHVCKLGQDRPIKTF 345
Query: 164 SAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGK 223
H++ V+A+ ++ +G+L+ S S D +IW C+ L N + +K+SP G
Sbjct: 346 QGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDL-QAHNKEIYTIKWSPTGP 404
Query: 224 ---------YILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS 274
+ +A+ D+T++LWD RG C+ T T H+ Y + + G+++ SGS
Sbjct: 405 GTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFS---PDGRYLASGS 461
Query: 275 EDNLVYIWNLQTKEIVQKLQG 295
D V+IWN QT +V +G
Sbjct: 462 FDKCVHIWNTQTGALVHSYRG 482
Score = 101 bits (251), Expect = 1e-21
Identities = 67/220 (30%), Positives = 107/220 (48%), Gaps = 22/220 (10%)
Query: 121 LKGHSNYVFCCNFNPPSNLIISGSFDETVKIW---EVKTGKCLKTLSAH----------- 166
L+GH + VF C +NP S+L+ SGS D T +IW E T + + H
Sbjct: 165 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPS 224
Query: 167 SDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYIL 226
+ V+++ +N G+L+ +GSYDG RIW G TL P+ +K++ G +IL
Sbjct: 225 NKDVTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTL-GQHKGPIFALKWNKKGNFIL 282
Query: 227 TATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT 286
+A +D T +WD G + + H + + T S S D +++ L
Sbjct: 283 SAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNT----FASCSTDMCIHVCKLGQ 338
Query: 287 KEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
++ QGHT+ V + PT NL+AS + +D T+K+W
Sbjct: 339 DRPIKTFQGHTNEVNAIKWDPTGNLLASCS--DDMTLKIW 376
Score = 95.9 bits (237), Expect = 4e-20
Identities = 56/169 (33%), Positives = 82/169 (48%), Gaps = 10/169 (5%)
Query: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWS--- 92
T GHT V+++K+ P G LAS S D + IW L HN EI + WS
Sbjct: 344 TFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTG 403
Query: 93 ------SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFD 146
+ + L SAS D T++LWDV G C+ TL H V+ F+P + SGSFD
Sbjct: 404 PGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFD 463
Query: 147 ETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195
+ V IW +TG + + + + V +N +G + + + DG + D
Sbjct: 464 KCVHIWNTQTGALVHSYRG-TGGIFEVCWNAAGDKVGASASDGSVCVLD 511
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 123 bits (308), Expect = 3e-28
Identities = 62/188 (32%), Positives = 102/188 (54%), Gaps = 6/188 (3%)
Query: 139 LIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAAS 198
L+ +G D V +W + C+ +L+ H+ PV +V N LIV+GS G R+WD +
Sbjct: 35 LLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEA 94
Query: 199 GQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCI 258
+ L+TL+ + + F P G+++ + + D +KLWD R C+ Y GH C+
Sbjct: 95 AKILRTLMGH-KANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCL 153
Query: 259 FANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALE 318
FS GKW+ S ++D+ V +W+L +++ + GHT V HP E L+AS +
Sbjct: 154 --RFS-PDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGS-- 208
Query: 319 NDKTIKLW 326
+D+TI+ W
Sbjct: 209 SDRTIRFW 216
Score = 119 bits (299), Expect = 3e-27
Identities = 65/209 (31%), Positives = 105/209 (50%), Gaps = 2/209 (0%)
Query: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDS 95
+L GHT V SV+ + E + + S I +W K +TL GH I + +
Sbjct: 58 SLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYG 117
Query: 96 SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVK 155
+ S S D +KLWD+R C+ +GHS V C F+P + S + D TVK+W++
Sbjct: 118 EFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLT 177
Query: 156 TGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSF 215
GK + H+ PV+ V F+ + L+ SGS D R WD Q + + ++ + PV
Sbjct: 178 AGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVV-SCIEGEPGPVRS 236
Query: 216 VKFSPNGKYILTATLDNTLKLWDYSRGRC 244
V F+P+G + + D +L+++ + RC
Sbjct: 237 VLFNPDGCCLYSGCQD-SLRVYGWEPERC 264
Score = 118 bits (295), Expect = 8e-27
Identities = 62/230 (26%), Positives = 115/230 (50%), Gaps = 5/230 (2%)
Query: 79 LYGHNLEISDVAWSSDSSRLVSAS-DDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPS 137
+ H +S + S RL++ DD + LW + C+ +L GH++ V N P
Sbjct: 16 IVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPE 75
Query: 138 NLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAA 197
LI++GS ++++W+++ K L+TL H + ++ F+ G + SGS D ++WD
Sbjct: 76 ELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIR 135
Query: 198 SGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYC 257
C+ + V ++FSP+GK++ +A D+T+KLWD + G+ + + GH
Sbjct: 136 RKGCVFRY-RGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNV 194
Query: 258 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHP 307
+ + + SGS D + W+L+ ++V ++G V S +P
Sbjct: 195 VEFH---PNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNP 241
Score = 111 bits (277), Expect = 1e-24
Identities = 63/248 (25%), Positives = 115/248 (46%), Gaps = 6/248 (2%)
Query: 37 LVGHTEAVSSVKFSP-NGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDS 95
+V H VSS+ +G LA+ D + +W +L GH + V ++
Sbjct: 16 IVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPE 75
Query: 96 SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVK 155
+V+ S ++++WD+ + K L+TL GH + +F+P + SGS D +K+W+++
Sbjct: 76 ELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIR 135
Query: 156 TGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSF 215
C+ HS V + F+ G + S + D ++WD +G+ + PV+
Sbjct: 136 RKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEF-PGHTGPVNV 194
Query: 216 VKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSE 275
V+F PN + + + D T++ WD + + + G + N G + SG +
Sbjct: 195 VEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFN---PDGCCLYSGCQ 251
Query: 276 DNL-VYIW 282
D+L VY W
Sbjct: 252 DSLRVYGW 259
Score = 34.3 bits (77), Expect = 0.16
Identities = 16/60 (26%), Positives = 30/60 (50%), Gaps = 2/60 (3%)
Query: 267 GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
G+ + +G +D V +W++ + L GHT V S + E LI + + +I++W
Sbjct: 33 GRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGS--QSGSIRVW 90
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 122 bits (306), Expect = 4e-28
Identities = 91/289 (31%), Positives = 146/289 (50%), Gaps = 23/289 (7%)
Query: 13 LALSSSANQS----KEVPENPNYAL-KCTLVGHTEAVSSVKFSPNGEWLASSSADRLIII 67
+ LS+S +++ K + NY + + L GH+ VS V S +G++ S S D + +
Sbjct: 30 MILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRL 89
Query: 68 WGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLK--GHS 125
W G + GH ++ VA+SSD+ ++VS S DKT+KLW+ G C T++ HS
Sbjct: 90 WDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL-GVCKYTVQDESHS 148
Query: 126 NYVFCCNFNPPSN--LIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIV 183
+V C F+P S+ +I+S +D+ VK+W + K H+ ++ V + GSL
Sbjct: 149 EWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCA 208
Query: 184 SGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGR 243
SG DG +WD G+ L TL D ++ + FSPN +Y L A ++K+WD G+
Sbjct: 209 SGGKDGQAMLWDLNEGKHLYTL--DGGDIINALCFSPN-RYWLCAATGPSIKIWDLE-GK 264
Query: 244 CLKTY-------TGHKNEK-YCIFANFSVTGGKWIVSGSEDNLVYIWNL 284
+ T K E C +S G + + +G DNLV +W +
Sbjct: 265 IIVDELKQEVISTSSKAEPPQCTSLAWSADG-QTLFAGYTDNLVRVWQV 312
Score = 114 bits (285), Expect = 1e-25
Identities = 85/272 (31%), Positives = 136/272 (50%), Gaps = 17/272 (6%)
Query: 33 LKCTLVGHTEAVSSVKFSPN-GEWLASSSADRLIIIWGAYD-----GKYEKTLYGHNLEI 86
L+ TL GH V+ + +P + + S+S D+ II+W G ++ L GH+ +
Sbjct: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFV 66
Query: 87 SDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFD 146
SDV SSD +S S D TL+LWD+ +G + GH+ V F+ + I+SGS D
Sbjct: 67 SDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRD 126
Query: 147 ETVKIWEVKTGKCLKTL--SAHSDPVSAVHF--NCSGSLIVSGSYDGLCRIWDAASGQCL 202
+T+K+W G C T+ +HS+ VS V F N S +IVS +D L ++W+ A+ + L
Sbjct: 127 KTIKLWNT-LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK-L 184
Query: 203 KTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANF 262
KT ++ V SP+G + D LWD + G+ L T G I
Sbjct: 185 KTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD-----IINAL 239
Query: 263 SVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ 294
+ ++ + + + IW+L+ K IV +L+
Sbjct: 240 CFSPNRYWLCAATGPSIKIWDLEGKIIVDELK 271
Score = 89.0 bits (219), Expect = 5e-18
Identities = 67/217 (30%), Positives = 100/217 (46%), Gaps = 11/217 (5%)
Query: 120 TLKGHSNYVFCCNFNPP-SNLIISGSFDETVKIW-----EVKTGKCLKTLSAHSDPVSAV 173
TLKGH+ +V P ++I+S S D+T+ +W E G + L HS VS V
Sbjct: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69
Query: 174 HFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNT 233
+ G +SGS+DG R+WD +G + V +S V FS + + I++ + D T
Sbjct: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLS-VAFSSDNRQIVSGSRDKT 128
Query: 234 LKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGK-WIVSGSEDNLVYIWNLQTKEIVQK 292
+KLW+ + G C T + ++ FS IVS D LV +WNL ++
Sbjct: 129 IKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTN 187
Query: 293 LQGHTDVVISAACHPTENLIASAALENDKTIKLWMSN 329
GHT + + P +L AS D LW N
Sbjct: 188 HIGHTGYLNTVTVSPDGSLCASGG--KDGQAMLWDLN 222
Score = 47.8 bits (112), Expect = 1e-05
Identities = 35/137 (25%), Positives = 66/137 (48%), Gaps = 11/137 (8%)
Query: 30 NYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDV 89
N LK +GHT +++V SP+G AS D ++W +GK+ TL G ++ I+ +
Sbjct: 181 NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDI-INAL 239
Query: 90 AWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLK-------GHSNYVFCCN--FNPPSNLI 140
+S + L +A+ ++K+WD+ + LK + C + ++ +
Sbjct: 240 CFSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTL 298
Query: 141 ISGSFDETVKIWEVKTG 157
+G D V++W+V G
Sbjct: 299 FAGYTDNLVRVWQVTIG 315
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 121 bits (303), Expect = 1e-27
Identities = 77/236 (32%), Positives = 127/236 (53%), Gaps = 19/236 (8%)
Query: 94 DSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWE 153
D ++VS D T+K+WD + +C + L GH+ V C ++ +II+GS D TV++W+
Sbjct: 276 DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYD--ERVIITGSSDSTVRVWD 333
Query: 154 VKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQ--CLKTLVDDDNP 211
V TG+ L TL H + V + FN ++V+ S D +WD AS L+ ++
Sbjct: 334 VNTGEMLNTLIHHCEAVLHLRFN--NGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRA 391
Query: 212 PVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIV 271
V+ V F + KYI++A+ D T+K+W+ S ++T GHK C+ + +V
Sbjct: 392 AVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYR-----DRLVV 444
Query: 272 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTEN-LIASAALENDKTIKLW 326
SGS DN + +W+++ ++ L+GH ++V C +N I S A D IK+W
Sbjct: 445 SGSSDNTIRLWDIECGACLRVLEGHEELV---RCIRFDNKRIVSGAY--DGKIKVW 495
Score = 98.2 bits (243), Expect = 9e-21
Identities = 59/172 (34%), Positives = 92/172 (53%), Gaps = 17/172 (9%)
Query: 33 LKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWS 92
L+ LVGH AV+ V F + +++ S+S DR I +W ++ +TL GH I+ + +
Sbjct: 382 LRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYR 439
Query: 93 SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW 152
+VS S D T++LWD+ G CL+ L+GH V C F+ + I+SG++D +K+W
Sbjct: 440 D--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVW 495
Query: 153 EVKTG---------KCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195
++ CL+TL HS V + F+ IVS S+D IWD
Sbjct: 496 DLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFD--EFQIVSSSHDDTILIWD 545
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.130 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,948,555
Number of Sequences: 37866
Number of extensions: 545891
Number of successful extensions: 6038
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 297
Number of HSP's successfully gapped in prelim test: 92
Number of HSP's that attempted gapping in prelim test: 1228
Number of HSP's gapped (non-prelim): 1902
length of query: 330
length of database: 18,247,518
effective HSP length: 103
effective length of query: 227
effective length of database: 14,347,320
effective search space: 3256841640
effective search space used: 3256841640
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.