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Search of human proteins with 225579152
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
(643 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|225579152 insulin-like growth factor binding protein, acid la... 1297 0.0
gi|4826772 insulin-like growth factor binding protein, acid labi... 1206 0.0
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 192 6e-49
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 192 6e-49
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 185 1e-46
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 172 9e-43
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 167 3e-41
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 162 1e-39
gi|194440719 chondroadherin-like [Homo sapiens] 162 1e-39
gi|4758460 glycoprotein V (platelet) [Homo sapiens] 161 2e-39
gi|76880480 hypothetical protein LOC9865 [Homo sapiens] 159 1e-38
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 158 1e-38
gi|226342931 podocan-like 1 isoform 1 [Homo sapiens] 155 1e-37
gi|226342933 podocan-like 1 isoform 2 [Homo sapiens] 154 2e-37
gi|62912472 leucine-rich repeat-containing G protein-coupled rec... 152 9e-37
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 150 3e-36
gi|8394456 toll-like receptor 9 isoform A precursor [Homo sapiens] 147 3e-35
gi|193083139 leucine rich repeat containing 32 precursor [Homo s... 146 7e-35
gi|5031707 leucine rich repeat containing 32 precursor [Homo sap... 146 7e-35
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 145 1e-34
gi|4507531 toll-like receptor 3 [Homo sapiens] 144 2e-34
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo... 143 6e-34
gi|198041768 synleurin [Homo sapiens] 142 7e-34
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 140 3e-33
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 140 4e-33
gi|45505137 podocan [Homo sapiens] 140 5e-33
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 136 7e-32
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 136 7e-32
gi|122937309 leucine rich repeat containing 4B [Homo sapiens] 134 3e-31
gi|13194201 reticulon 4 receptor precursor [Homo sapiens] 131 2e-30
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 1297 bits (3356), Expect = 0.0
Identities = 643/643 (100%), Positives = 643/643 (100%)
Query: 1 MALRKAGDLEPQFTPERRFRLCWYQAHSGRALLGPPPQASPPAGGLALALLLLSWVALGP 60
MALRKAGDLEPQFTPERRFRLCWYQAHSGRALLGPPPQASPPAGGLALALLLLSWVALGP
Sbjct: 1 MALRKAGDLEPQFTPERRFRLCWYQAHSGRALLGPPPQASPPAGGLALALLLLSWVALGP 60
Query: 61 RSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLD 120
RSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLD
Sbjct: 61 RSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLD 120
Query: 121 GNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTF 180
GNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTF
Sbjct: 121 GNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTF 180
Query: 181 AHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLA 240
AHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLA
Sbjct: 181 AHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLA 240
Query: 241 GNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAF 300
GNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAF
Sbjct: 241 GNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAF 300
Query: 301 LGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLG 360
LGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLG
Sbjct: 301 LGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLG 360
Query: 361 HNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVF 420
HNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVF
Sbjct: 361 HNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVF 420
Query: 421 RGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLT 480
RGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLT
Sbjct: 421 RGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLT 480
Query: 481 SNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLL 540
SNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLL
Sbjct: 481 SNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLL 540
Query: 541 APLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFV 600
APLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFV
Sbjct: 541 APLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFV 600
Query: 601 QAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEAHFAPC 643
QAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEAHFAPC
Sbjct: 601 QAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEAHFAPC 643
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 1206 bits (3119), Expect = 0.0
Identities = 600/600 (100%), Positives = 600/600 (100%)
Query: 44 GGLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNL 103
GGLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNL
Sbjct: 6 GGLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNL 65
Query: 104 TRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLC 163
TRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLC
Sbjct: 66 TRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLC 125
Query: 164 HLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVL 223
HLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVL
Sbjct: 126 HLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVL 185
Query: 224 PDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQ 283
PDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQ
Sbjct: 186 PDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQ 245
Query: 284 KLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASL 343
KLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASL
Sbjct: 246 KLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASL 305
Query: 344 RPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVA 403
RPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVA
Sbjct: 306 RPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVA 365
Query: 404 VMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGI 463
VMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGI
Sbjct: 366 VMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGI 425
Query: 464 EEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAF 523
EEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAF
Sbjct: 426 EEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAF 485
Query: 524 WLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLK 583
WLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLK
Sbjct: 486 WLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLK 545
Query: 584 ALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEAHFAPC 643
ALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEAHFAPC
Sbjct: 546 ALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEAHFAPC 605
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 192 bits (489), Expect = 6e-49
Identities = 154/472 (32%), Positives = 210/472 (44%), Gaps = 61/472 (12%)
Query: 161 NLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSL 220
N L + + L F + AL +L + N LSR+ G F LGSL L+L N L
Sbjct: 60 NAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKL 119
Query: 221 AVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLP 280
VLP F+GL SL L+L+ N+L +QPA FS + L+EL L N L I F L
Sbjct: 120 QVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLV 179
Query: 281 RLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAI 340
L KL L +N + ++P F L L+ L L NR+ + TF GL+ L+ L L N I
Sbjct: 180 GLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQI 239
Query: 341 ASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLT 400
L P F + H L+ L L +N I QL F L QL LTL N L+E+ G F +
Sbjct: 240 GLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMP 299
Query: 401 NVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL 460
N+ + L N + +LP+ VF L +L L L + + I P F GL+
Sbjct: 300 NLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLT------------ 347
Query: 461 VGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ 520
EL EL L +N L L +F+ L L+ + L NRL +LP + +
Sbjct: 348 ------------ELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVN 395
Query: 521 RAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGC 580
+ + +N+LE LP + LG+L L L + NPW C
Sbjct: 396 GLMAIQLQNNQLENLPLGIFDHLGKLCELRLYD--------------------NPWRCDS 435
Query: 581 PLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDL 632
+ LR++ L N PR G D P C SP V G L
Sbjct: 436 DILPLRNWLLLNQ---PRL------GTDTVP--------VCFSPANVRGQSL 470
Score = 185 bits (469), Expect = 1e-46
Identities = 136/431 (31%), Positives = 212/431 (49%), Gaps = 11/431 (2%)
Query: 79 CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSL 138
CP+ C CS + C+ + +P +P +L + +++ + + F N+S+L
Sbjct: 31 CPSECTCSRASQVE-----CTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISAL 85
Query: 139 GFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSR 198
L ++ +L + P A L +L +L L N+L+ L +G F +L SL LS+N+L +
Sbjct: 86 IALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQ 145
Query: 199 LEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAEL 258
++ F +L +L L N L +PD AF L L +L L N L ++ P +F L L
Sbjct: 146 IQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNL 205
Query: 259 RELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAG 318
+ L L N L I F L LQ+L L +N I ++PG F L+ L LS+N ++
Sbjct: 206 QVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQ 265
Query: 319 LLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQL 378
L F L L L L N++ L F + L EL L N I L + F L QL
Sbjct: 266 LPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQL 325
Query: 379 EVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGR 438
+VL L NQ+ + GAF GLT + ++L N L++L VFR L L ++ L+ + L +
Sbjct: 326 QVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQ 385
Query: 439 IRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKL 498
+ + F ++GL + L++N L + L +L EL L N P R + L
Sbjct: 386 LPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN-----PWRCDSDILPL 440
Query: 499 -EYLLLSRNRL 508
+LLL++ RL
Sbjct: 441 RNWLLLNQPRL 451
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 192 bits (489), Expect = 6e-49
Identities = 154/472 (32%), Positives = 210/472 (44%), Gaps = 61/472 (12%)
Query: 161 NLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSL 220
N L + + L F + AL +L + N LSR+ G F LGSL L+L N L
Sbjct: 54 NAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKL 113
Query: 221 AVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLP 280
VLP F+GL SL L+L+ N+L +QPA FS + L+EL L N L I F L
Sbjct: 114 QVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLV 173
Query: 281 RLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAI 340
L KL L +N + ++P F L L+ L L NR+ + TF GL+ L+ L L N I
Sbjct: 174 GLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQI 233
Query: 341 ASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLT 400
L P F + H L+ L L +N I QL F L QL LTL N L+E+ G F +
Sbjct: 234 GLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMP 293
Query: 401 NVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL 460
N+ + L N + +LP+ VF L +L L L + + I P F GL+
Sbjct: 294 NLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLT------------ 341
Query: 461 VGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ 520
EL EL L +N L L +F+ L L+ + L NRL +LP + +
Sbjct: 342 ------------ELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVN 389
Query: 521 RAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGC 580
+ + +N+LE LP + LG+L L L + NPW C
Sbjct: 390 GLMAIQLQNNQLENLPLGIFDHLGKLCELRLYD--------------------NPWRCDS 429
Query: 581 PLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDL 632
+ LR++ L N PR G D P C SP V G L
Sbjct: 430 DILPLRNWLLLNQ---PRL------GTDTVP--------VCFSPANVRGQSL 464
Score = 185 bits (469), Expect = 1e-46
Identities = 136/431 (31%), Positives = 212/431 (49%), Gaps = 11/431 (2%)
Query: 79 CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSL 138
CP+ C CS + C+ + +P +P +L + +++ + + F N+S+L
Sbjct: 25 CPSECTCSRASQVE-----CTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISAL 79
Query: 139 GFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSR 198
L ++ +L + P A L +L +L L N+L+ L +G F +L SL LS+N+L +
Sbjct: 80 IALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQ 139
Query: 199 LEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAEL 258
++ F +L +L L N L +PD AF L L +L L N L ++ P +F L L
Sbjct: 140 IQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNL 199
Query: 259 RELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAG 318
+ L L N L I F L LQ+L L +N I ++PG F L+ L LS+N ++
Sbjct: 200 QVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQ 259
Query: 319 LLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQL 378
L F L L L L N++ L F + L EL L N I L + F L QL
Sbjct: 260 LPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQL 319
Query: 379 EVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGR 438
+VL L NQ+ + GAF GLT + ++L N L++L VFR L L ++ L+ + L +
Sbjct: 320 QVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQ 379
Query: 439 IRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKL 498
+ + F ++GL + L++N L + L +L EL L N P R + L
Sbjct: 380 LPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN-----PWRCDSDILPL 434
Query: 499 -EYLLLSRNRL 508
+LLL++ RL
Sbjct: 435 RNWLLLNQPRL 445
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 185 bits (469), Expect = 1e-46
Identities = 144/452 (31%), Positives = 213/452 (47%), Gaps = 21/452 (4%)
Query: 39 ASPPAGGLALA----LLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADEL 94
A P GGL LLL W+ L +P T C AAC C+ D
Sbjct: 2 ARPVRGGLGAPRRSPCLLLLWLLL-----LRLEPVTAAAGPRAPCAAACTCAGD------ 50
Query: 95 SVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQ 154
S+ C R L LP +P T++L L N LS + PA F++L +L + L +L ++ P
Sbjct: 51 SLDCGGRGLAALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAV-PS 109
Query: 155 ALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLN 214
++ L L+ N++RS+ +L L LS N ++ + + F + +LN
Sbjct: 110 LGAASSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELN 169
Query: 215 LGWNSLAVLPDAAFRGLG-SLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKA 273
L N + L AF GL SL L L+ NR+ L F L L +LDL+RN +R I+
Sbjct: 170 LAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIEG 228
Query: 274 NVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVL 333
F L L+ L L RN I+ + GAF GL + L L +N + + + GL L L
Sbjct: 229 LTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQL 288
Query: 334 RLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKA 393
LS+N+IA + + + L EL L N + +L E S L L VL L HN + +
Sbjct: 289 HLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAE 348
Query: 394 GAFLGLTNVAVMNLSGNCLRNLPEQ---VFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGL 450
GAF GL ++ V++L N + E F GL L L L G+ + + F+GL GL
Sbjct: 349 GAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGL 408
Query: 451 RRLFLKDNGLVGIEEQSLWGLAELLELDLTSN 482
L L N + ++ + + L EL ++S+
Sbjct: 409 EHLNLGGNAIRSVQFDAFVKMKNLKELHISSD 440
Score = 154 bits (390), Expect = 2e-37
Identities = 127/424 (29%), Positives = 198/424 (46%), Gaps = 16/424 (3%)
Query: 213 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 272
LNL +N L+ + A F L +L+E+ L N L + P+L + + + L L N +R+++
Sbjct: 73 LNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAV-PSLGAASSHVVSLFLQHNKIRSVE 131
Query: 273 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLL-GLR 331
+ L+ L L N I V F ++ L+L+ NR+ L F GL L
Sbjct: 132 GSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLL 191
Query: 332 VLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEV 391
LRLS N I L R FK L L +L L NRIR + +F+GL LEVL L N + ++
Sbjct: 192 TLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKL 250
Query: 392 KAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLR 451
GAF GL+ + V++L N L + GL LH LHL + + RI ++ L
Sbjct: 251 TDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLH 310
Query: 452 RLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLA-- 509
L L N L ++E+SL L+ L L L+ N ++H+ F+GL L L L N ++
Sbjct: 311 ELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGT 370
Query: 510 -ELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFT----PQPP 564
E + A L L + N+++++ + L L +L+L N++R+ +
Sbjct: 371 IEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMK 430
Query: 565 GLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASP 624
L+ L + + + C C LK L P + R +QA P + +I P
Sbjct: 431 NLKELHISSDSFLCDCQLKWL------PPWLIGRMLQAFVTATCAHPESLKGQSIFSVPP 484
Query: 625 PEVV 628
V
Sbjct: 485 ESFV 488
Score = 61.2 bits (147), Expect = 3e-09
Identities = 48/154 (31%), Positives = 72/154 (46%), Gaps = 3/154 (1%)
Query: 117 LWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLA 176
L L N+++ + + L L L L L+ ++L L +L L L N + +A
Sbjct: 288 LHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIA 347
Query: 177 LGTFAHTPALASLGLSNNRLS-RLED--GLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGS 233
G F +L L L +N +S +ED G F GL SL L L N + + AF GL
Sbjct: 348 EGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEG 407
Query: 234 LRELVLAGNRLAYLQPALFSGLAELRELDLSRNA 267
L L L GN + +Q F + L+EL +S ++
Sbjct: 408 LEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDS 441
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 172 bits (436), Expect = 9e-43
Identities = 138/449 (30%), Positives = 215/449 (47%), Gaps = 16/449 (3%)
Query: 52 LLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVP 111
LL ++ALG G P A P C A C C D D CS + LT +P+G+
Sbjct: 7 LLCFLALGLLGSAG-----PSGAAPPLCAAPCSCDGDRRVD-----CSGKGLTAVPEGLS 56
Query: 112 GGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQ 171
TQAL + NN++ +P AF+N L L L G L + P+AL GL+ L L L+ NQ
Sbjct: 57 AFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQ 116
Query: 172 LRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGL 231
L+++ AL SL L N ++ + + FEGL L L L NSL +P L
Sbjct: 117 LKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNL 176
Query: 232 GSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNL 291
+L+ L LA N+++ + F+ L+ L L L N +R++ + F L L+ L L+ N
Sbjct: 177 PTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNN 236
Query: 292 IAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDL 351
+ P A L +L+ L N ++ + + F G LR + L N ++ + F +L
Sbjct: 237 LGEF-PQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNL 295
Query: 352 HFLEELQL-GHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN 410
L L + G + ++Q + G LE LTL ++ + + ++LS N
Sbjct: 296 SDLHSLVIRGASMVQQFP--NLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYN 353
Query: 411 CLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWG 470
+R+LP F G L + L+ + + +I+ TF GL LR L L N + I ++
Sbjct: 354 NIRDLPS--FNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFAT 411
Query: 471 LAELLELDLTSNQLTHLPHRLFQGLGKLE 499
L + LD++ N+LT P GL +L+
Sbjct: 412 LGPITNLDVSFNELTSFPTEGLNGLNQLK 440
Score = 150 bits (379), Expect = 3e-36
Identities = 120/394 (30%), Positives = 183/394 (46%), Gaps = 26/394 (6%)
Query: 205 EGLGSLWD-LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDL 263
EGL + L++ N++ LP+ AF+ L EL LAGN L+++ P SGL EL+ L L
Sbjct: 53 EGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTL 112
Query: 264 SRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDT 323
N L+ + + L LQ L LD N I +V +F GL LR L L N + +
Sbjct: 113 QNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHP 172
Query: 324 FPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTL 383
L L+ L L+ N I+S+ F +L L L L +N+IR L++ F+GL LE L L
Sbjct: 173 LSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDL 232
Query: 384 DHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHT 443
++N L E A L ++ + N + +P+ F G L ++HL + L +
Sbjct: 233 NYNNLGEFPQ-AIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSA 291
Query: 444 FTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRL------------ 491
F LS L L ++ +V + +L G L L LT +++ +P+ L
Sbjct: 292 FHNLSDLHSLVIRGASMVQ-QFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDL 350
Query: 492 ----------FQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLA 541
F G LE + L RN++ ++ L LD+S N + + + A
Sbjct: 351 SYNNIRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFA 410
Query: 542 PLGRLRYLSLRNNSLRTF-TPQPPGLERLWLEGN 574
LG + L + N L +F T GL +L L GN
Sbjct: 411 TLGPITNLDVSFNELTSFPTEGLNGLNQLKLVGN 444
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 167 bits (423), Expect = 3e-41
Identities = 143/440 (32%), Positives = 206/440 (46%), Gaps = 12/440 (2%)
Query: 69 GTPGEAEGP-ACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSV 127
G P GP ACPA C C +D LS CS L+ +P + T L L NNL+ +
Sbjct: 24 GAPQPGPGPTACPAPCHCQ--EDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTEL 81
Query: 128 PPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALA 187
P F +L L L L G L + QA GL +L L L+ NQL + P+L
Sbjct: 82 QPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQ 141
Query: 188 SLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYL 247
SL L N +S + + FEGL SL L L N+L +P A L +L+ + LA NR++++
Sbjct: 142 SLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHI 201
Query: 248 QPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALR 307
F L L L L N ++ + + F L L+ L L+ N + P A L L+
Sbjct: 202 PDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF-PVAIRTLGRLQ 260
Query: 308 WLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQL-GHNRIRQ 366
L +N + + E F G L+ + N I + F+ L L L L G I++
Sbjct: 261 ELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQE 320
Query: 367 LAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKL 426
+ +G LE+LTL ++ + +G L + V+ LS N + LP KL
Sbjct: 321 FPD--LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS--LHRCQKL 376
Query: 427 HSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTH 486
+ L+ + + I TF+ LS L+ L L N + I ++ L L++LDLT NQLT
Sbjct: 377 EEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTT 436
Query: 487 LPHRLFQGLGKLEYLLLSRN 506
LP GLG L +L L N
Sbjct: 437 LP---LAGLGGLMHLKLKGN 453
Score = 154 bits (388), Expect = 3e-37
Identities = 119/351 (33%), Positives = 174/351 (49%), Gaps = 6/351 (1%)
Query: 213 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 272
L+L N+L L F L L EL L+GN L+++ FSGL L+ L L N L I
Sbjct: 71 LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIP 130
Query: 273 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRV 332
A +LP LQ L LD NLI+ V +F GL +LR L L N + + L L+
Sbjct: 131 AEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQA 190
Query: 333 LRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVK 392
+ L+ N I+ + F++L L L L +NRI+ L SFEGL LE L L++N+LQE
Sbjct: 191 MTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFP 250
Query: 393 AGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRR 452
A L + + N ++ +PE+ F G L ++H + + + F L L
Sbjct: 251 V-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHT 309
Query: 453 LFLKDNGLVGIEE-QSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAEL 511
L L NG + I+E L G L L LT + LP + Q L +L L LS N++ EL
Sbjct: 310 LSL--NGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEEL 367
Query: 512 PADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQ 562
P +L Q+ + + HNR+ + + L L+ L L N++R+ P+
Sbjct: 368 P--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPE 416
Score = 150 bits (380), Expect = 3e-36
Identities = 124/394 (31%), Positives = 189/394 (47%), Gaps = 9/394 (2%)
Query: 184 PALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNR 243
P A L LS N L+ L+ GLF L L +L L N L+ +P AF GL SL+ L+L N+
Sbjct: 66 PLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQ 125
Query: 244 LAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGL 303
L + L L+ L L N + + F L L+ L+LD N + + A L
Sbjct: 126 LGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNL 185
Query: 304 KALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNR 363
AL+ + L+ NR++ + + F L L VL L +N I L +F+ LH LE L L +N+
Sbjct: 186 PALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNK 245
Query: 364 IRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGL 423
+++ + LG+L+ L +N ++ + AF+G + ++ N ++ + F+ L
Sbjct: 246 LQEFPV-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYL 304
Query: 424 GKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQ 483
KLH+L L G+ + P G + L L L G+ + L L L+L+ NQ
Sbjct: 305 PKLHTLSLNGAMDIQEFP-DLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQ 363
Query: 484 LTHLP--HRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLA 541
+ LP HR KLE + L NR+ E+ AD L LD+S N + ++ +
Sbjct: 364 IEELPSLHR----CQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFS 419
Query: 542 PLGRLRYLSLRNNSLRTF-TPQPPGLERLWLEGN 574
L L L L +N L T GL L L+GN
Sbjct: 420 TLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGN 453
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 162 bits (409), Expect = 1e-39
Identities = 141/474 (29%), Positives = 217/474 (45%), Gaps = 43/474 (9%)
Query: 43 AGGLALALLLLSWVALGPRSLEGADPGTPGEAEGPA----CPAACVCSYDDDADELSVFC 98
A L LLL + + RS G G G+ G A CP C C D + C
Sbjct: 8 ARAAGLGLLLCAVLGRAGRSDSGGR-GELGQPSGVAAERPCPTTCRCLGD------LLDC 60
Query: 99 SSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLG 158
S + L RLP+ +P L L N LS + ++ +L SL + L +L ++ P
Sbjct: 61 SRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETI-PNLGPV 119
Query: 159 LENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWN 218
N+ L L N++ + +L +L LS+N +S L+
Sbjct: 120 SANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQ------------------ 161
Query: 219 SLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAE-LRELDLSRNALRAIKANVFV 277
AF L L+ L L NR+ ++P F LA L L L+RN + AI +F
Sbjct: 162 -------TAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMF- 212
Query: 278 QLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSH 337
+LP+LQ L L+RN I V F GL AL+ L + N V L++ F GL + +L+L H
Sbjct: 213 KLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDH 272
Query: 338 NAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFL 397
N + + L L+EL L N I +++ ++E +L L L N L + +FL
Sbjct: 273 NNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFL 332
Query: 398 GLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLG---RIRPHTFTGLSGLRRLF 454
GL+ + +++ N + + + FRGL L +L L+ + + F+GL LRRL
Sbjct: 333 GLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLI 392
Query: 455 LKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRL 508
L+ N + I +++ GL L LDL+ N + L F + KL+ L L+ + L
Sbjct: 393 LQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 446
Score = 143 bits (360), Expect = 6e-34
Identities = 122/426 (28%), Positives = 200/426 (46%), Gaps = 36/426 (8%)
Query: 186 LASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLA 245
+A L LS+NRLS ++ L SL ++ L N L +P+ ++ L LAGNR+
Sbjct: 76 VARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS-ANITLLSLAGNRIV 134
Query: 246 YLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKA 305
+ P L LDLS N + ++ F L +L+ LYL+ N + ++ PG F L
Sbjct: 135 EILPEHLKEFQSLETLDLSSNNISELQT-AFPAL-QLKYLYLNSNRVTSMEPGYFDNLAN 192
Query: 306 LRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIR 365
L VL+L+ N I+++ P+ FK L L+ L+L N+I+
Sbjct: 193 T-----------------------LLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIK 228
Query: 366 QLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGK 425
+ +F+GLG L+ L + N + ++ GAF GL+N+ ++ L N L + + GL
Sbjct: 229 NVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLM 288
Query: 426 LHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLT 485
L LHL + + RI P + L L L N L +++ S GL+ L L + +N+++
Sbjct: 289 LQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVS 348
Query: 486 HLPHRLFQGLGKLEYLLLSRNRLAELPAD---ALGPLQRAFWLDVSHNRLEALPNSLLAP 542
++ F+GL L+ L L N ++ D A L + L + NR+ ++
Sbjct: 349 YIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTG 408
Query: 543 LGRLRYLSLRNNSLRTFT----PQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPR 598
L L +L L +N++ + Q L++L L + C C LK L + +N
Sbjct: 409 LDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAEN--NFQS 466
Query: 599 FVQAIC 604
FV A C
Sbjct: 467 FVNASC 472
>gi|194440719 chondroadherin-like [Homo sapiens]
Length = 762
Score = 162 bits (409), Expect = 1e-39
Identities = 184/607 (30%), Positives = 240/607 (39%), Gaps = 107/607 (17%)
Query: 73 EAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAF 132
+A CP AC+C D V C +NLT +PD +P TQ L L GN L +P AAF
Sbjct: 27 QAAAQRCPQACIC----DNSRRHVACRYQNLTEVPDAIPELTQRLDLQGNLLKVIPAAAF 82
Query: 133 QN------------------------LSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLE 168
Q L L LNL L L +AL GL +L L LE
Sbjct: 83 QGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLELE 142
Query: 169 RNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAF 228
N L L GTF ALA+L L++N L L F+GL + L L N+L+VL A
Sbjct: 143 GNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEAL 202
Query: 229 RGLGSLRELVLAGNRLAYL------------------QPALFSG------LAELRELDLS 264
GL +LR L L N L L P ++G L LREL L
Sbjct: 203 AGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLD 262
Query: 265 RNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHN------RVAG 318
AL+A+ F PRL L L N + + P G LR L L N +
Sbjct: 263 GGALQALGPRAFAHCPRLHTLDLRGNQLDTLPP--LQGPGQLRRLRLQGNPLWCGCQARP 320
Query: 319 LLEDTFPGLLGLRVL---------RLSHNAIASLRPRTFK-------DLHFLEELQL--- 359
LLE L RV RL A+ +LRP + + LEE +
Sbjct: 321 LLE----WLARARVRSDGACQGPRRLRGEALDALRPWDLRCPGDAAQEEEELEERAVAGP 376
Query: 360 -----------GHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLS 408
G R R+ + + + + LQ V G ++ +++L
Sbjct: 377 RAPPRGPPRGPGEERAVAPCPRACVCVPESRHSSCEGCGLQAVPRGF---PSDTQLLDLR 433
Query: 409 GNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSL 468
N ++P F GLG L SLHL+ + + GL L L+L DN L G+ +L
Sbjct: 434 RNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAAL 493
Query: 469 WGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVS 528
G L L L N+ +P + L L L L N + L LG + W+ +S
Sbjct: 494 EGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLS 553
Query: 529 HNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQP----PGLERLWLEGNPWDCGCPLKA 584
NR+ + L P L L L N LR P L L L GN PL+A
Sbjct: 554 GNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGN------PLRA 607
Query: 585 LRDFALQ 591
LRD A Q
Sbjct: 608 LRDGAFQ 614
Score = 125 bits (314), Expect = 1e-28
Identities = 102/307 (33%), Positives = 139/307 (45%), Gaps = 9/307 (2%)
Query: 59 GPRSLEGADPGTPGEAEGPA-CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQAL 117
GPR+ P PGE A CP ACVC + C L +P G P TQ L
Sbjct: 375 GPRAPPRGPPRGPGEERAVAPCPRACVCVPESRHSS----CEGCGLQAVPRGFPSDTQLL 430
Query: 118 WLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLAL 177
L N+ SVP AAF L L L+LQ + LE AL GL L +L+L NQL L+
Sbjct: 431 DLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSA 490
Query: 178 GTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLREL 237
P L L L NR ++ L SL+ L+L N++ L +LR +
Sbjct: 491 AALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWV 550
Query: 238 VLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAP 297
L+GNR+ + EL +L L RN LR + LP L +L L N + A+
Sbjct: 551 YLSGNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRD 610
Query: 298 GAFLGL-KALRWLDLSHNRVAGLLEDTFPGL-LGLRVLRLSHNAIASLRPRTFKDLHFLE 355
GAF + ++L+ L L+ + + + F GL GL+ L L N + +L L LE
Sbjct: 611 GAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRAL--PALPSLSQLE 668
Query: 356 ELQLGHN 362
+ L N
Sbjct: 669 LIDLSSN 675
Score = 112 bits (279), Expect = 1e-24
Identities = 154/551 (27%), Positives = 206/551 (37%), Gaps = 93/551 (16%)
Query: 109 GVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLE 168
G G L L N L +P AFQ L + +L L L L P+AL GL L L L
Sbjct: 155 GALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLH 214
Query: 169 RNQLRSL----------------------------------------------ALG--TF 180
N+L++L ALG F
Sbjct: 215 HNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLDGGALQALGPRAF 274
Query: 181 AHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSL----------------AVLP 224
AH P L +L L N+L L +G G L L L N L V
Sbjct: 275 AHCPRLHTLDLRGNQLDTLPP--LQGPGQLRRLRLQGNPLWCGCQARPLLEWLARARVRS 332
Query: 225 DAAFRGLGSLRELVLAGNRLAYLQP--ALFSGLAELRELDLSRNALRAIKANVFVQLPRL 282
D A +G LR G L L+P G A E +L A+ +A PR
Sbjct: 333 DGACQGPRRLR-----GEALDALRPWDLRCPGDAAQEEEELEERAVAGPRAP-----PRG 382
Query: 283 QKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGL----LEDTFPGLLGLRVLRLSHN 338
A P A + + R H+ G + FP ++L L N
Sbjct: 383 PPRGPGEERAVAPCPRACVCVPESR-----HSSCEGCGLQAVPRGFPS--DTQLLDLRRN 435
Query: 339 AIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLG 398
S+ F L L L L H I +L + GLG+L L L NQL + A A G
Sbjct: 436 HFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEG 495
Query: 399 LTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDN 458
+ + L N +P R L L SLHL+ + + R+ P LR ++L N
Sbjct: 496 APRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGN 555
Query: 459 GLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGP 518
+ + +L EL +L L NQL +P +GL L L LS N L L A P
Sbjct: 556 RITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQP 615
Query: 519 LQRAF-WLDVSHNRLEALPNSLLAPLG-RLRYLSLRNNSLRTF--TPQPPGLERLWLEGN 574
+ R+ L ++ + LE + + LG L+ L L+ N LR P LE + L N
Sbjct: 616 VGRSLQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALPALPSLSQLELIDLSSN 675
Query: 575 PWDCGCPLKAL 585
P+ C C L L
Sbjct: 676 PFHCDCQLLPL 686
Score = 105 bits (262), Expect = 1e-22
Identities = 106/291 (36%), Positives = 137/291 (47%), Gaps = 35/291 (12%)
Query: 213 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 272
L+L N +P AAF GLG L L L +A L+ +GL L L LS N L +
Sbjct: 430 LDLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLS 489
Query: 273 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRV 332
A PRL LYL+RN V PGA ALR L P L L
Sbjct: 490 AAALEGAPRLGYLYLERNRFLQV-PGA-----ALRAL---------------PSLFSLH- 527
Query: 333 LRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVK 392
L NA+ L P L + L NRI +++ + +LE L LD NQL+EV
Sbjct: 528 --LQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLREVP 585
Query: 393 AGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGK-LHSLHLEGSCLGRIRPHTFTGLS-GL 450
GA GL + + LSGN LR L + F+ +G+ L L L S L +I P F+GL GL
Sbjct: 586 TGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPGL 645
Query: 451 RRLFLKDNGLVGIEEQSLWGLAELLELDLTSN------QLTHLPHRLFQGL 495
+ L L+ N L + +L L++L +DL+SN QL L HR GL
Sbjct: 646 QSLHLQKNQLRAL--PALPSLSQLELIDLSSNPFHCDCQLLPL-HRWLTGL 693
>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
Length = 560
Score = 161 bits (407), Expect = 2e-39
Identities = 122/360 (33%), Positives = 172/360 (47%), Gaps = 1/360 (0%)
Query: 199 LEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAEL 258
L+ F G+ L L + + ++ + F L L+ L L+ N++ +L AL + L
Sbjct: 65 LQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLL 124
Query: 259 RELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAG 318
+L L NALR I N+F +L LQ+L L++N + + F L+ L+ LDLS N +
Sbjct: 125 EQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTH 184
Query: 319 LLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQL 378
L + L L L N + SL L L ELQ N IR +A +F+ L L
Sbjct: 185 LPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNL 244
Query: 379 EVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGR 438
LTL N L + + FL N+ ++ L N L LP +F +G L L L + L
Sbjct: 245 SSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRT 304
Query: 439 IRPHTFTGLSGLRRLFLK-DNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGK 497
+ F LS LR L + L + + + GL EL L L SN LT LP L +GLGK
Sbjct: 305 LPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGK 364
Query: 498 LEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLR 557
L + L RNRL LP L + + HN+LE LP + L RL + L +NS R
Sbjct: 365 LRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNSWR 424
Score = 155 bits (391), Expect = 1e-37
Identities = 133/453 (29%), Positives = 200/453 (44%), Gaps = 53/453 (11%)
Query: 79 CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSL 138
CP AC C + D A CS ++ R+ AL L N L
Sbjct: 21 CPPACKCVFRDAAQ-----CSGGDVARI--------SALGLPTN---------------L 52
Query: 139 GFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSR 198
+ L G G L+ Q+ G+ L L + + + ++A GTF+ L +L LS N+++
Sbjct: 53 THILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITH 112
Query: 199 LEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAEL 258
L L + + L L L N+L + F+ L +L+EL L N+L +L +LF+ L L
Sbjct: 113 LPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENL 172
Query: 259 RELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAG 318
+ LDLS N L + + +L++L L N + ++ G L AL L N +
Sbjct: 173 KLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRS 232
Query: 319 LLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQL 378
+ F L L L LS N +A L F H L L L N + +L F +G L
Sbjct: 233 IAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGL 292
Query: 379 EVLTLDHNQLQEVKAGAFLGLTNVAVMNLS-GNCLRNLPEQVFRGLGKLHSLHLEGSCLG 437
+ L L+ QL+ + A AF L+ + + ++ L LP+ F+GLG+L L L
Sbjct: 293 QELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALH----- 347
Query: 438 RIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGK 497
NGL + + L GL +L ++ L N+L LP LF+ L
Sbjct: 348 -------------------SNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSS 388
Query: 498 LEYLLLSRNRLAELPADALGPLQRAFWLDVSHN 530
LE + L N+L LP D G L R + + HN
Sbjct: 389 LESVQLDHNQLETLPGDVFGALPRLTEVLLGHN 421
Score = 118 bits (296), Expect = 1e-26
Identities = 95/295 (32%), Positives = 134/295 (45%), Gaps = 28/295 (9%)
Query: 299 AFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQ 358
+F G+ L+ L +S + ++ + TF L+ L+ LRLS N I L + LE+L
Sbjct: 69 SFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLF 128
Query: 359 LGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPE- 417
L HN +R + + F+ L L+ L L+ NQL + A F L N+ +++LSGN L +LP+
Sbjct: 129 LDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKG 188
Query: 418 -----------------------QVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLF 454
+ LG L L + + I P F L L L
Sbjct: 189 LLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLT 248
Query: 455 LKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPAD 514
L N L + L L L N L LP LF +G L+ L L+R +L LPA
Sbjct: 249 LSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAA 308
Query: 515 ALGPLQRAFWLDVSHN-RLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLER 568
A L R +L V+ + RL ALP LG L+ L+L +N L T P GL R
Sbjct: 309 AFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGL---TALPDGLLR 360
Score = 79.3 bits (194), Expect = 1e-14
Identities = 58/161 (36%), Positives = 76/161 (47%), Gaps = 23/161 (14%)
Query: 109 GVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLE 168
G GG Q LWL+ L ++P AAF+NLS L +L + +L P+
Sbjct: 287 GEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGV------TLSPR-------------- 326
Query: 169 RNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAF 228
L +L G F L L L +N L+ L DGL GLG L ++L N L LP A F
Sbjct: 327 ---LSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALF 383
Query: 229 RGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALR 269
R L SL + L N+L L +F L L E+ L N+ R
Sbjct: 384 RNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNSWR 424
Score = 66.6 bits (161), Expect = 7e-11
Identities = 54/161 (33%), Positives = 76/161 (47%), Gaps = 1/161 (0%)
Query: 397 LGL-TNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFL 455
LGL TN+ + L G L Q F G+ L L + S + + P TF+ L L+ L L
Sbjct: 46 LGLPTNLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRL 105
Query: 456 KDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADA 515
N + + L + L +L L N L + +FQ L L+ L L++N+L LPA
Sbjct: 106 SRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASL 165
Query: 516 LGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSL 556
L+ LD+S N L LP LL +L L L +N L
Sbjct: 166 FTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRL 206
>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
Length = 811
Score = 159 bits (401), Expect = 1e-38
Identities = 119/340 (35%), Positives = 162/340 (47%), Gaps = 11/340 (3%)
Query: 77 PACPAACVCSYDDDADELSVFCSSRNLTRLP--DGVPGGTQALW--LDGNNLSSVPPAAF 132
P CP C C + + C++R L +P +P L L GN ++++ F
Sbjct: 25 PVCPERCDCQHPQH-----LLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAFDF 79
Query: 133 QNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLS 192
L L L+LQ Q+ SL P+ L L L+L N L++LA GT A L L +
Sbjct: 80 HRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYAN 139
Query: 193 NNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALF 252
N +SRL G FEGL SL L L N+L LPDA F LG+L L L NR+ +L F
Sbjct: 140 GNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAF 199
Query: 253 SGLAELRELDLSRNALRAI--KANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLD 310
+ L +LR L+LS N L+ A F L L L L N + + P F L L L
Sbjct: 200 AQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLS 259
Query: 311 LSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAER 370
L N++ L + F GL LR LRL N ++ L + LH LE L L N + L
Sbjct: 260 LRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPA 319
Query: 371 SFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN 410
+F LG+L L+L +N L + F + ++L GN
Sbjct: 320 TFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGN 359
Score = 157 bits (396), Expect = 4e-38
Identities = 114/306 (37%), Positives = 148/306 (48%), Gaps = 30/306 (9%)
Query: 311 LSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAER 370
L N + + F L LR L L +N I SL P+TF+ L LEEL LG+N ++ LA
Sbjct: 66 LGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPG 125
Query: 371 SFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLH 430
+ L +L +L + N++ + G+F GL ++ + L GN L LP+ VF LG L LH
Sbjct: 126 TLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLH 185
Query: 431 LEG-----------SCLGRIR---------------PHTFTGLSGLRRLFLKDNGLVGIE 464
LE + LG++R TF L L L L N L +
Sbjct: 186 LESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLG 245
Query: 465 EQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFW 524
+ L L L L NQLTHL F GL L L L NRL++LP L PL
Sbjct: 246 PRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEA 305
Query: 525 LDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFT----PQPPGLERLWLEGNPWDCGC 580
LD+S N L AL + LGRLR LSLRNN+L + P L RL L+GN W C C
Sbjct: 306 LDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGNGWTCDC 365
Query: 581 PLKALR 586
L+ L+
Sbjct: 366 RLRGLK 371
Score = 80.1 bits (196), Expect = 6e-15
Identities = 52/157 (33%), Positives = 78/157 (49%)
Query: 401 NVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL 460
+V +L GN + N+ F LG+L L L+ + + + P TF LS L L+L +N L
Sbjct: 60 DVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLL 119
Query: 461 VGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ 520
+ +L L +L L N+++ L F+GL L L L N L LP PL
Sbjct: 120 QALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLG 179
Query: 521 RAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLR 557
+L + NR+ L + A LG+LR+L+L N L+
Sbjct: 180 NLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQ 216
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 158 bits (400), Expect = 1e-38
Identities = 118/331 (35%), Positives = 165/331 (49%), Gaps = 13/331 (3%)
Query: 93 ELSVFCSSRNLTRL-----------PDGVPG--GTQALWLDGNNLSSVPPAAFQNLSSLG 139
E F S+ NLT++ PD G + L + G++ ++ F NL+SLG
Sbjct: 65 ETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLG 124
Query: 140 FLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRL 199
L L L +L L L LHL+ NQL++L F L +L L+ N L++L
Sbjct: 125 KLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQL 184
Query: 200 EDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELR 259
+ LF L SL L L N+L+ LP F LGSL+EL L N ++ L P +FS L L
Sbjct: 185 PEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLE 244
Query: 260 ELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGL 319
L L RNA+ + ++F L L L L N++ + G F L L L+HN++ +
Sbjct: 245 RLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETV 304
Query: 320 LEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLE 379
E TF L LR L LS+NAI L F+DL L +L LG N + L F+ L +LE
Sbjct: 305 AEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLE 364
Query: 380 VLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN 410
+L+L NQL + G F N+ + L GN
Sbjct: 365 LLSLSKNQLTTLPEGIFDTNYNLFNLALHGN 395
Score = 155 bits (392), Expect = 1e-37
Identities = 125/383 (32%), Positives = 172/383 (44%), Gaps = 12/383 (3%)
Query: 79 CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAF---QNL 135
CP C C + VFCS L +P +P T+ + + +++ AF NL
Sbjct: 22 CPMGCDCFVQE------VFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNL 75
Query: 136 SSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNR 195
+ + FLN Q L P A GL L L + + +L+ F++ +L L L+ N
Sbjct: 76 TKVVFLNTQ---LCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNM 132
Query: 196 LSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGL 255
L L +GLF+ L +L L+L N L LP F+ L L+ L LA N LA L LF L
Sbjct: 133 LEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPL 192
Query: 256 AELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNR 315
L+ L LS NAL + VF +L LQ+L+LD N I+ + P F L L L L N
Sbjct: 193 TSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNA 252
Query: 316 VAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGL 375
+ L F L L L L N + L F L L L HN++ +AE +F L
Sbjct: 253 ITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHL 312
Query: 376 GQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSC 435
L L L +N + + AG F L + + L N L L +F+ L KL L L +
Sbjct: 313 SNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQ 372
Query: 436 LGRIRPHTFTGLSGLRRLFLKDN 458
L + F L L L N
Sbjct: 373 LTTLPEGIFDTNYNLFNLALHGN 395
Score = 150 bits (379), Expect = 3e-36
Identities = 128/399 (32%), Positives = 174/399 (43%), Gaps = 51/399 (12%)
Query: 224 PDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQ 283
PDA F GL L +L + G+ L +FS L L +L L+ N L A+ +F L L+
Sbjct: 90 PDA-FGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALE 148
Query: 284 KLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASL 343
L+L N + A+ F L L+ L+L+ N +A L E+ F L L+ L+LS+NA++ L
Sbjct: 149 SLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGL 208
Query: 344 RPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVA 403
F L L+EL L N I +L + F L LE L L N + + F L N+
Sbjct: 209 PQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLT 268
Query: 404 VMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGI 463
++L N LR LP +F L L L + L + TF LS LR L L N + +
Sbjct: 269 FLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHL 328
Query: 464 EEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAF 523
L EL++L L SN LT L LFQ L KLE L LS+N+L LP
Sbjct: 329 PAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGI-------- 380
Query: 524 WLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLK 583
D ++N L L L GNPW C C L
Sbjct: 381 -FDTNYN-----------------------------------LFNLALHGNPWQCDCHLA 404
Query: 584 ALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCA 622
L ++ Q + +Q C G PAY + A
Sbjct: 405 YLFNWLQQYTDRLLN-IQTYCAG-----PAYLKGQVVPA 437
>gi|226342931 podocan-like 1 isoform 1 [Homo sapiens]
Length = 512
Score = 155 bits (391), Expect = 1e-37
Identities = 170/527 (32%), Positives = 217/527 (41%), Gaps = 105/527 (19%)
Query: 45 GLAL-ALLLLSWVALGPRSLEGA-DPGTP--GEAEGP---ACPAACVCSYDDDADELSVF 97
GLA+ LLL + GP + G D P GE+ P ACP C C D D
Sbjct: 5 GLAMWPSLLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVD----- 59
Query: 98 CSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGS--LEPQA 155
C +L PD + Q L L N L +P LS L LNL + S L +A
Sbjct: 60 CDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEA 119
Query: 156 LLGLENLCHLHLERNQL--------RSLALG-------------TFAHTPALASLGLSNN 194
L L HL + N+L RSL + TF PAL S+ L NN
Sbjct: 120 FESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNN 179
Query: 195 RLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSG 254
+LS A LP AFRG ++ L L+ N+L+YL P+L
Sbjct: 180 QLSN----------------------AGLPPDAFRGSEAIATLSLSNNQLSYLPPSL--- 214
Query: 255 LAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHN 314
P L++L+L NLI+ V GA LR L L HN
Sbjct: 215 ------------------------PPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHN 250
Query: 315 RV--AGLLEDTFPGLLGLRVLRLSHNAIASL---RPRTFKDLHFLEELQLGHNRIRQLAE 369
++ +GL TF L L L LSHN + ++ PRT LH LG NRIRQ+
Sbjct: 251 QLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILH------LGRNRIRQVEA 304
Query: 370 RSFEGLGQLEVLTLDHNQL--QEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLH 427
G L L L HNQL + AGA L + ++L GN L +P + R L L
Sbjct: 305 ARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALV 364
Query: 428 SLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVG--IEEQSLWGLAELLELDLTSNQLT 485
H + LG GL L L N L + ++ L L LDL NQLT
Sbjct: 365 LPHNHVAALG---ARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLT 421
Query: 486 HLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRL 532
LP L GL L+ L RN+L L + L L + L ++HNRL
Sbjct: 422 RLPMGLPTGLRTLQ---LQRNQLRMLEPEPLAGLDQLRELSLAHNRL 465
Score = 103 bits (258), Expect = 4e-22
Identities = 99/274 (36%), Positives = 126/274 (45%), Gaps = 17/274 (6%)
Query: 99 SSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQL--GSLEPQAL 156
S+ L+ LP +P + L L N +S VP A + L L LQ QL L+
Sbjct: 203 SNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTF 262
Query: 157 LGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLG 216
L +L +L L NQL ++ G LA L L NR+ ++E G L L L
Sbjct: 263 SKLHSLEYLDLSHNQLTTVPAGL---PRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQ 319
Query: 217 WNSLAV--LPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKAN 274
N L LP A R L L L L GN L + PAL LR L L N + A+ A
Sbjct: 320 HNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPAL---PRRLRALVLPHNHVAALGAR 376
Query: 275 VFVQLPRLQKLYLDRNLIAA--VAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGL-LGLR 331
V P L +L L N +A+ V AF L+ALR LDL+ N++ L GL GLR
Sbjct: 377 DLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPM----GLPTGLR 432
Query: 332 VLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIR 365
L+L N + L P L L EL L HNR+R
Sbjct: 433 TLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLR 466
Score = 47.8 bits (112), Expect = 3e-05
Identities = 50/178 (28%), Positives = 80/178 (44%), Gaps = 11/178 (6%)
Query: 402 VAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLV 461
V ++ G LR P+ + R L L+ + L + + + LSGLR L L +N +
Sbjct: 55 VDTVDCDGLDLRVFPDNITRAA---QHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLIS 111
Query: 462 --GIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALG-- 517
G+ +++ L +L L + N+L+ P L + L + L+ N++ E+ G
Sbjct: 112 SEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVAD---LAANQVMEIFPLTFGEK 168
Query: 518 PLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQ-PPGLERLWLEGN 574
P R+ +L + LP + LSL NN L P PP LERL L+ N
Sbjct: 169 PALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNN 226
>gi|226342933 podocan-like 1 isoform 2 [Homo sapiens]
Length = 510
Score = 154 bits (390), Expect = 2e-37
Identities = 167/520 (32%), Positives = 213/520 (40%), Gaps = 104/520 (20%)
Query: 51 LLLSWVALGPRSLEGA-DPGTP--GEAEGP---ACPAACVCSYDDDADELSVFCSSRNLT 104
LLL + GP + G D P GE+ P ACP C C D D C +L
Sbjct: 10 LLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVD-----CDGLDLR 64
Query: 105 RLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGS--LEPQALLGLENL 162
PD + Q L L N L +P LS L LNL + S L +A L L
Sbjct: 65 VFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQL 124
Query: 163 CHLHLERNQL--------RSLALG-------------TFAHTPALASLGLSNNRLSRLED 201
HL + N+L RSL + TF PAL S+ L NN+LS
Sbjct: 125 QHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSN--- 181
Query: 202 GLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELREL 261
A LP AFRG ++ L L+ N+L+YL P+L
Sbjct: 182 -------------------AGLPPDAFRGSEAIATLSLSNNQLSYLPPSL---------- 212
Query: 262 DLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRV--AGL 319
P L++L+L NLI+ V GA LR L L HN++ +GL
Sbjct: 213 -----------------PPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGL 255
Query: 320 LEDTFPGLLGLRVLRLSHNAIASL---RPRTFKDLHFLEELQLGHNRIRQLAERSFEGLG 376
TF L L L LSHN + ++ PRT LH LG NRIRQ+ G
Sbjct: 256 DATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILH------LGRNRIRQVEAARLHGAR 309
Query: 377 QLEVLTLDHNQL--QEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGS 434
L L L HNQL + AGA L + ++L GN L +P + R L L H +
Sbjct: 310 GLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVA 369
Query: 435 CLGRIRPHTFTGLSGLRRLFLKDNGLVG--IEEQSLWGLAELLELDLTSNQLTHLPHRLF 492
LG GL L L N L + ++ L L LDL NQLT LP L
Sbjct: 370 ALG---ARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLP 426
Query: 493 QGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRL 532
GL L+ L RN+L L + L L + L ++HNRL
Sbjct: 427 TGLRTLQ---LQRNQLRMLEPEPLAGLDQLRELSLAHNRL 463
Score = 103 bits (258), Expect = 4e-22
Identities = 99/274 (36%), Positives = 126/274 (45%), Gaps = 17/274 (6%)
Query: 99 SSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQL--GSLEPQAL 156
S+ L+ LP +P + L L N +S VP A + L L LQ QL L+
Sbjct: 201 SNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTF 260
Query: 157 LGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLG 216
L +L +L L NQL ++ G LA L L NR+ ++E G L L L
Sbjct: 261 SKLHSLEYLDLSHNQLTTVPAGL---PRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQ 317
Query: 217 WNSLAV--LPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKAN 274
N L LP A R L L L L GN L + PAL LR L L N + A+ A
Sbjct: 318 HNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPAL---PRRLRALVLPHNHVAALGAR 374
Query: 275 VFVQLPRLQKLYLDRNLIAA--VAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGL-LGLR 331
V P L +L L N +A+ V AF L+ALR LDL+ N++ L GL GLR
Sbjct: 375 DLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPM----GLPTGLR 430
Query: 332 VLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIR 365
L+L N + L P L L EL L HNR+R
Sbjct: 431 TLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLR 464
Score = 47.8 bits (112), Expect = 3e-05
Identities = 50/178 (28%), Positives = 80/178 (44%), Gaps = 11/178 (6%)
Query: 402 VAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLV 461
V ++ G LR P+ + R L L+ + L + + + LSGLR L L +N +
Sbjct: 53 VDTVDCDGLDLRVFPDNITRAA---QHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLIS 109
Query: 462 --GIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALG-- 517
G+ +++ L +L L + N+L+ P L + L + L+ N++ E+ G
Sbjct: 110 SEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVAD---LAANQVMEIFPLTFGEK 166
Query: 518 PLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQ-PPGLERLWLEGN 574
P R+ +L + LP + LSL NN L P PP LERL L+ N
Sbjct: 167 PALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNN 224
>gi|62912472 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 2 [Homo sapiens]
Length = 915
Score = 152 bits (384), Expect = 9e-37
Identities = 118/350 (33%), Positives = 173/350 (49%), Gaps = 6/350 (1%)
Query: 214 NLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKA 273
+L N+L L F L L EL L+GN L+++ FSGL L+ L L N L I A
Sbjct: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 79
Query: 274 NVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVL 333
+LP LQ L LD NLI+ V +F GL +LR L L N + + L L+ +
Sbjct: 80 EALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAM 139
Query: 334 RLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKA 393
L+ N I+ + F++L L L L +NRI+ L SFEGL LE L L++N+LQE
Sbjct: 140 TLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPV 199
Query: 394 GAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRL 453
A L + + N ++ +PE+ F G L ++H + + + F L L L
Sbjct: 200 -AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTL 258
Query: 454 FLKDNGLVGIEE-QSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELP 512
L NG + I+E L G L L LT + LP + Q L +L L LS N++ ELP
Sbjct: 259 SL--NGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP 316
Query: 513 ADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQ 562
+L Q+ + + HNR+ + + L L+ L L N++R+ P+
Sbjct: 317 --SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPE 364
Score = 147 bits (371), Expect = 3e-35
Identities = 121/392 (30%), Positives = 189/392 (48%), Gaps = 9/392 (2%)
Query: 186 LASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLA 245
+++ LS N L+ L+ GLF L L +L L N L+ +P AF GL SL+ L+L N+L
Sbjct: 16 ISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLG 75
Query: 246 YLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKA 305
+ L L+ L L N + + F L L+ L+LD N + + A L A
Sbjct: 76 GIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPA 135
Query: 306 LRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIR 365
L+ + L+ NR++ + + F L L VL L +N I L +F+ LH LE L L +N+++
Sbjct: 136 LQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQ 195
Query: 366 QLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGK 425
+ + LG+L+ L +N ++ + AF+G + ++ N ++ + F+ L K
Sbjct: 196 EFPV-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPK 254
Query: 426 LHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLT 485
LH+L L G+ + P G + L L L G+ + L L L+L+ NQ+
Sbjct: 255 LHTLSLNGAMDIQEFP-DLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIE 313
Query: 486 HLP--HRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPL 543
LP HR KLE + L NR+ E+ AD L LD+S N + ++ + L
Sbjct: 314 ELPSLHR----CQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTL 369
Query: 544 GRLRYLSLRNNSLRTF-TPQPPGLERLWLEGN 574
L L L +N L T GL L L+GN
Sbjct: 370 HSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGN 401
Score = 138 bits (348), Expect = 1e-32
Identities = 125/389 (32%), Positives = 178/389 (45%), Gaps = 9/389 (2%)
Query: 167 LERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDA 226
L N L L G F H L L LS N LS + F GL SL L L N L +P
Sbjct: 21 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 80
Query: 227 AFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLY 286
A L SL+ L L N ++ + F GL+ LR L L NAL I LP LQ +
Sbjct: 81 ALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMT 140
Query: 287 LDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPR 346
L N I+ + AF L +L L L +NR+ L +F GL L L L++N + P
Sbjct: 141 LALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF-PV 199
Query: 347 TFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMN 406
+ L L+EL +N I+ + E++F G L+ + N +Q V AF L + ++
Sbjct: 200 AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLS 259
Query: 407 LSGNC-LRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEE 465
L+G ++ P+ +G L L L + + + L LR L L N + E
Sbjct: 260 LNGAMDIQEFPD--LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIE--EL 315
Query: 466 QSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWL 525
SL +L E+ L N++ + F L L+ L LS N + + +A L L
Sbjct: 316 PSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKL 375
Query: 526 DVSHNRLEALPNSLLAPLGRLRYLSLRNN 554
D++ N+L LP LA LG L +L L+ N
Sbjct: 376 DLTDNQLTTLP---LAGLGGLMHLKLKGN 401
Score = 137 bits (345), Expect = 3e-32
Identities = 130/413 (31%), Positives = 185/413 (44%), Gaps = 46/413 (11%)
Query: 77 PACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGT---QALWLDGNNLSSVPPAAFQ 133
P C S A +LS+ NLT L G+ + L L GN+LS +P AF
Sbjct: 4 PRLTLVCQVSIIISARDLSM----NNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFS 59
Query: 134 NLSSLGFLNLQGGQLGSLEPQALL------------------------GLENLCHLHLER 169
L SL L LQ QLG + +AL GL +L HL L+
Sbjct: 60 GLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDD 119
Query: 170 NQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFR 229
N L + + + PAL ++ L+ NR+S + D F+ L SL L+L N + L +F
Sbjct: 120 NALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFE 179
Query: 230 GLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDR 289
GL +L L L N+L P L L+EL N ++AI F+ P LQ ++
Sbjct: 180 GLHNLETLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYD 238
Query: 290 NLIAAVAPGAFLGLKALRWLDLSHNRVAGLLE-DTFPGLLG---LRVLRLSHNAIASLRP 345
N I V AF L L L L+ G ++ FP L G L +L L+ I L
Sbjct: 239 NPIQFVGRSAFQYLPKLHTLSLN-----GAMDIQEFPDLKGTTSLEILTLTRAGIRLLPS 293
Query: 346 RTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVM 405
+ L L L+L HN+I +L S +LE + L HN++ E+ A F L+++ +
Sbjct: 294 GMCQQLPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQAL 351
Query: 406 NLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDN 458
+LS N +R++ + F L L L L + L + GL GL L LK N
Sbjct: 352 DLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTL---PLAGLGGLMHLKLKGN 401
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 150 bits (380), Expect = 3e-36
Identities = 122/367 (33%), Positives = 173/367 (47%), Gaps = 10/367 (2%)
Query: 213 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 272
L+L N+++ L L L EL LAGN L Y+ F+GL L+ L L N LR +
Sbjct: 71 LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVP 130
Query: 273 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRV 332
L LQ L LD N I+ V P F GL +LR L L N + + F L L+
Sbjct: 131 TEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQA 190
Query: 333 LRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVK 392
+ L+ N I + F +L L L L +NRI L ++ F+GL LE L L++N L E
Sbjct: 191 MTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFP 250
Query: 393 AGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRR 452
A L+N+ + N +R++PE+ F G L ++H + + + F L LR
Sbjct: 251 T-AIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRT 309
Query: 453 LFLKDNGLVGIEE-QSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAEL 511
L L NG I E L G A L L LT Q++ LP + L L+ L LS N L +L
Sbjct: 310 LTL--NGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDL 367
Query: 512 PADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQP----PGLE 567
P+ ++ Q+ +D+ HN + + L LR L+L N + P P L
Sbjct: 368 PSFSV--CQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLI 425
Query: 568 RLWLEGN 574
+L L N
Sbjct: 426 KLDLSSN 432
Score = 148 bits (373), Expect = 2e-35
Identities = 145/463 (31%), Positives = 205/463 (44%), Gaps = 17/463 (3%)
Query: 45 GLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLT 104
G+ L+L +L +A G G+ P + G CP C C D L V CS L+
Sbjct: 7 GVLLSLPVLLQLATG-----GSSPRSGVLLRG--CPTHCHCE-PDGRMLLRVDCSDLGLS 58
Query: 105 RLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCH 164
LP + T L L NN+S + P +L L L L G L + A GL +L
Sbjct: 59 ELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKV 118
Query: 165 LHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLP 224
L L+ NQLR + + +L SL L N +S + F GL SL L L N+L +P
Sbjct: 119 LMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIP 178
Query: 225 DAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQK 284
AFR L +L+ + LA N++ ++ F L+ L L L N + ++ F L L+
Sbjct: 179 VQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLET 238
Query: 285 LYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLR 344
L L+ N + P A L L+ L N + + E F G L + N I +
Sbjct: 239 LDLNYNNLDEF-PTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVG 297
Query: 345 PRTFKDLHFLEELQLGHNRIRQLAE-RSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVA 403
F+ L L L L N Q+ E G LE LTL Q+ + L N+
Sbjct: 298 RSAFQHLPELRTLTL--NGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQ 355
Query: 404 VMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGI 463
V++LS N L +LP F KL + L + + I+ TF L LR L L N + I
Sbjct: 356 VLDLSYNLLEDLPS--FSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAII 413
Query: 464 EEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRN 506
+ L L++LDL+SN L+ P GL L +L L+ N
Sbjct: 414 HPNAFSTLPSLIKLDLSSNLLSSFP---ITGLHGLTHLKLTGN 453
Score = 106 bits (264), Expect = 8e-23
Identities = 68/206 (33%), Positives = 100/206 (48%), Gaps = 1/206 (0%)
Query: 353 FLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL 412
F L L N I QL L LE L L N L + GAF GL ++ V+ L N L
Sbjct: 67 FTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQL 126
Query: 413 RNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLA 472
R++P + + L L SL L+ + + + P F+GL LR L+L DN L I Q+ L+
Sbjct: 127 RHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLS 186
Query: 473 ELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRL 532
L + L N++ H+P F L L L L NR+ L L LD+++N L
Sbjct: 187 ALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNL 246
Query: 533 EALPNSLLAPLGRLRYLSLRNNSLRT 558
+ P + + L L+ L +N++R+
Sbjct: 247 DEFPTA-IRTLSNLKELGFHSNNIRS 271
Score = 100 bits (250), Expect = 3e-21
Identities = 81/269 (30%), Positives = 122/269 (45%), Gaps = 4/269 (1%)
Query: 308 WLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQL 367
+LDLS N ++ LL + P L L LRL+ NA+ + F L+ L+ L L +N++R +
Sbjct: 70 YLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHV 129
Query: 368 AERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLH 427
+ + L L+ L LD N + V F GL ++ + L N L +P Q FR L L
Sbjct: 130 PTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQ 189
Query: 428 SLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHL 487
++ L + + I + F LS L L L +N + + ++ GL L LDL N L
Sbjct: 190 AMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF 249
Query: 488 PHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLR 547
P + + L L+ L N + +P A + N ++ + S L LR
Sbjct: 250 PTAI-RTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELR 308
Query: 548 YLSLRNNSLRTFTPQPPG---LERLWLEG 573
L+L S T P G LE L L G
Sbjct: 309 TLTLNGASQITEFPDLTGTANLESLTLTG 337
>gi|8394456 toll-like receptor 9 isoform A precursor [Homo sapiens]
Length = 1032
Score = 147 bits (371), Expect = 3e-35
Identities = 178/617 (28%), Positives = 251/617 (40%), Gaps = 111/617 (17%)
Query: 102 NLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLEN 161
NLT +P +P + L L N + + P NL++L L++ GG + +E
Sbjct: 210 NLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDV-GGNCRRCDHAPNPCME- 267
Query: 162 LCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSL- 220
C H + L TF+H L L L ++ LS L F GLG+L L+L N L
Sbjct: 268 -CPRHFPQ-----LHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLY 321
Query: 221 -AVLPDAAFRGLGSLRELVLAGN---RLAYLQPAL---FSGLAELRELDLSRNALRAIKA 273
+ AF+GL LR+L L+ N R+++ +L F L L+ELD+ R++
Sbjct: 322 KCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDE 381
Query: 274 NVF---VQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTF------ 324
+LP LQ L L N I G F LR++DLS NR++G E T
Sbjct: 382 TTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEAD 441
Query: 325 --------PGLLGLR-------------------VLRLSHNAIASLRPRTFKDLHFLEEL 357
PG L L LS N + +++P F L L+ L
Sbjct: 442 GGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCL 501
Query: 358 QLGHNRIRQLAERS-FEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN------ 410
+L HN I Q S F L L+VL L HN+L +F L + ++LS N
Sbjct: 502 RLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFGM 561
Query: 411 ---------------------CLRNLPEQVFRGL--GKLHSLHLEGSCLGR------IRP 441
N+ QV + L L +L G+ LG +
Sbjct: 562 QGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGHMWAEGDLYL 621
Query: 442 HTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLE-LDLTSNQLTHLPHRLFQGLGKLEY 500
H F GLSGL L L N L + Q+L L + L+ L L N L L KLE
Sbjct: 622 HFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEV 681
Query: 501 LLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRT-- 558
L L+ N+L L +L R LDVS N + + + LR L+L N+L+T
Sbjct: 682 LDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVD 741
Query: 559 ---FTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYT 615
F P L+ L + NP C C A DF L+ +AVP
Sbjct: 742 HSWFGPLASALQILDVSANPLHCACG-AAFMDFLLEVQAAVPGLP--------------- 785
Query: 616 YNNITCASPPEVVGLDL 632
+ + C SP ++ GL +
Sbjct: 786 -SRVKCGSPGQLQGLSI 801
Score = 103 bits (258), Expect = 4e-22
Identities = 144/545 (26%), Positives = 205/545 (37%), Gaps = 139/545 (25%)
Query: 186 LASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAV------------LPDAAFRGLGS 233
+ SL LS+NR+ L D F L SL LNL WN V + + F + +
Sbjct: 65 VTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVPT 124
Query: 234 LRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNL-- 291
L EL L+ N + + PAL L L LS + + + L L+ L++D N
Sbjct: 125 LEELNLSYNNIMTV-PALPKSLI---SLSLSHTNILMLDSASLAGLHALRFLFMDGNCYY 180
Query: 292 ------IAAVAPGAFLGL---------------------KALRWLDLSHNRVAGLLEDTF 324
VAPGA LGL +L +L LS+NR+ L +
Sbjct: 181 KNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDL 240
Query: 325 PGLLGLRVLRLSHNA----------------IASLRPRTFKDLHFLEELQLGHNRIRQLA 368
L LRVL + N L P TF L LE L L + + L
Sbjct: 241 ANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLN 300
Query: 369 ERSFEGLGQLEVLTLDHNQLQE--VKAGAFLGLTNVAVMNLS------------------ 408
F GLG L VL L N L + K AF GLT + +NLS
Sbjct: 301 ASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSF 360
Query: 409 ------------GNCLRNLPEQVFRGLGK---LHSLHLEGSCLGRIRPHTFTGLSGLRRL 453
G R+L E R L + L +L L+ + + + + F GLR +
Sbjct: 361 GSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYV 420
Query: 454 FLKDNGLVGIEE-----------QSLW----GLAEL------------------LELDLT 480
L DN + G E + +W LA LDL+
Sbjct: 421 DLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLS 480
Query: 481 SNQLTHLPHRLFQGLGKLEYLLLSRNRLAE-LPADALGPLQRAFWLDVSHNRLEALPNSL 539
N L + +F L L+ L LS N +++ + PL LD+SHN+L+
Sbjct: 481 RNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHS 540
Query: 540 LAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRF 599
L RL L L NS QP G++ + G+ + L+ LR +L + + +
Sbjct: 541 FTELPRLEALDLSYNS------QPFGMQGV---GHNFSFVAHLRTLRHLSLAHNNIHSQV 591
Query: 600 VQAIC 604
Q +C
Sbjct: 592 SQQLC 596
Score = 44.7 bits (104), Expect = 3e-04
Identities = 53/201 (26%), Positives = 79/201 (39%), Gaps = 35/201 (17%)
Query: 376 GQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSC 435
G + L+L N++ + F L ++ +NL NC P GL +H C
Sbjct: 63 GNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNC----PPV---GLSPMHF-----PC 110
Query: 436 LGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGL 495
I P TF + L L L N ++ + L+ L L+ + L GL
Sbjct: 111 HMTIEPSTFLAVPTLEELNLSYNNIMTVPALP----KSLISLSLSHTNILMLDSASLAGL 166
Query: 496 GKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNS 555
L +L + N ++ + LE P +LL LG L +LSL+ N+
Sbjct: 167 HALRFLFMDGN---------------CYYKNPCRQALEVAPGALLG-LGNLTHLSLKYNN 210
Query: 556 LRTFTPQ--PPGLERLWLEGN 574
L T P+ P LE L L N
Sbjct: 211 L-TVVPRNLPSSLEYLLLSYN 230
>gi|193083139 leucine rich repeat containing 32 precursor [Homo
sapiens]
Length = 662
Score = 146 bits (368), Expect = 7e-35
Identities = 172/558 (30%), Positives = 234/558 (41%), Gaps = 90/558 (16%)
Query: 96 VFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQA 155
V C L ++P +P T+ L L GN L S+ + ++L L+L ++ L+P A
Sbjct: 33 VSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGA 92
Query: 156 LLGLENLCHLHLERNQL---RSLALGTFAHTPALASLGLSNNRL-SRLEDGLFEGLGSLW 211
L +L HL L N+L +L+ G P + SL LS N L S L + L SL
Sbjct: 93 FQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLH 152
Query: 212 DLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAI 271
L+L NSL L FR + +L +L L N L ++ F GL L L+LSRN+L I
Sbjct: 153 TLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCI 212
Query: 272 KANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLK-ALRWLDLSHNRVAGLLEDTFPGLLGL 330
L +L+ L L N I A + + L WLDL N++ FP L L
Sbjct: 213 SD---FSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLL-----HFPDLAAL 264
Query: 331 R---VLRLSHNAI--ASLRPRTFKDLH--------------------------------- 352
L LS+N I + P+ K +H
Sbjct: 265 PRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSY 324
Query: 353 ---------FLEE------LQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFL 397
FLE L L N +R R L L +L L HN L+ ++ GA
Sbjct: 325 NEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGA-R 383
Query: 398 GLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGS----CLGRIRPH-----TFTGLS 448
L ++ + L GN LR+LP F L L L+L+G+ C G P F+G++
Sbjct: 384 ALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGIT 443
Query: 449 GLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGL-GKLEYLLLSRNR 507
LR L L DN + + + L ELDL+SN + GL LE L L N
Sbjct: 444 SLRSLSLVDNE-IELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNG 502
Query: 508 LAELPAD--ALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPG 565
L L D L+R L+++ NRL LP A L L LRNNS G
Sbjct: 503 LMVLQVDLPCFICLKR---LNLAENRLSHLPAWTQAV--SLEVLDLRNNSFSLLPGSAMG 557
Query: 566 -----LERLWLEGNPWDC 578
L RL+L+GNP C
Sbjct: 558 GLETSLRRLYLQGNPLSC 575
Score = 100 bits (248), Expect = 5e-21
Identities = 90/278 (32%), Positives = 124/278 (44%), Gaps = 29/278 (10%)
Query: 309 LDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLA 368
LDLS N++ +L LR L LS N I+ L+P F+ L LE L L HNR+
Sbjct: 54 LDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMAT 113
Query: 369 ERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL-RNLPEQVFRGLGKLH 427
S GLG L V ++LSGN L L E++ LH
Sbjct: 114 ALSAGGLGP---------------------LPRVTSLDLSGNSLYSGLLERLLGEAPSLH 152
Query: 428 SLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHL 487
+L L + L R+ HTF + L +L L N L+ IE+ + GL L L+L+ N LT +
Sbjct: 153 TLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCI 212
Query: 488 PHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ-RAFWLDVSHNRLEALPNSLLAPLGRL 546
Q +L L LS N + + + + WLD+ N+L P+ LA L RL
Sbjct: 213 SDFSLQ---QLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPD--LAALPRL 267
Query: 547 RYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKA 584
YL+L NN +R T P + + W PL A
Sbjct: 268 IYLNLSNNLIRLPTGPPQDSKGIHAPSEGWS-ALPLSA 304
>gi|5031707 leucine rich repeat containing 32 precursor [Homo
sapiens]
Length = 662
Score = 146 bits (368), Expect = 7e-35
Identities = 172/558 (30%), Positives = 234/558 (41%), Gaps = 90/558 (16%)
Query: 96 VFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQA 155
V C L ++P +P T+ L L GN L S+ + ++L L+L ++ L+P A
Sbjct: 33 VSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGA 92
Query: 156 LLGLENLCHLHLERNQL---RSLALGTFAHTPALASLGLSNNRL-SRLEDGLFEGLGSLW 211
L +L HL L N+L +L+ G P + SL LS N L S L + L SL
Sbjct: 93 FQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLH 152
Query: 212 DLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAI 271
L+L NSL L FR + +L +L L N L ++ F GL L L+LSRN+L I
Sbjct: 153 TLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCI 212
Query: 272 KANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLK-ALRWLDLSHNRVAGLLEDTFPGLLGL 330
L +L+ L L N I A + + L WLDL N++ FP L L
Sbjct: 213 SD---FSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLL-----HFPDLAAL 264
Query: 331 R---VLRLSHNAI--ASLRPRTFKDLH--------------------------------- 352
L LS+N I + P+ K +H
Sbjct: 265 PRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSY 324
Query: 353 ---------FLEE------LQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFL 397
FLE L L N +R R L L +L L HN L+ ++ GA
Sbjct: 325 NEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGA-R 383
Query: 398 GLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGS----CLGRIRPH-----TFTGLS 448
L ++ + L GN LR+LP F L L L+L+G+ C G P F+G++
Sbjct: 384 ALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGIT 443
Query: 449 GLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGL-GKLEYLLLSRNR 507
LR L L DN + + + L ELDL+SN + GL LE L L N
Sbjct: 444 SLRSLSLVDNE-IELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNG 502
Query: 508 LAELPAD--ALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPG 565
L L D L+R L+++ NRL LP A L L LRNNS G
Sbjct: 503 LMVLQVDLPCFICLKR---LNLAENRLSHLPAWTQAV--SLEVLDLRNNSFSLLPGSAMG 557
Query: 566 -----LERLWLEGNPWDC 578
L RL+L+GNP C
Sbjct: 558 GLETSLRRLYLQGNPLSC 575
Score = 100 bits (248), Expect = 5e-21
Identities = 90/278 (32%), Positives = 124/278 (44%), Gaps = 29/278 (10%)
Query: 309 LDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLA 368
LDLS N++ +L LR L LS N I+ L+P F+ L LE L L HNR+
Sbjct: 54 LDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMAT 113
Query: 369 ERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL-RNLPEQVFRGLGKLH 427
S GLG L V ++LSGN L L E++ LH
Sbjct: 114 ALSAGGLGP---------------------LPRVTSLDLSGNSLYSGLLERLLGEAPSLH 152
Query: 428 SLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHL 487
+L L + L R+ HTF + L +L L N L+ IE+ + GL L L+L+ N LT +
Sbjct: 153 TLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCI 212
Query: 488 PHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ-RAFWLDVSHNRLEALPNSLLAPLGRL 546
Q +L L LS N + + + + WLD+ N+L P+ LA L RL
Sbjct: 213 SDFSLQ---QLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPD--LAALPRL 267
Query: 547 RYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKA 584
YL+L NN +R T P + + W PL A
Sbjct: 268 IYLNLSNNLIRLPTGPPQDSKGIHAPSEGWS-ALPLSA 304
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 145 bits (365), Expect = 1e-34
Identities = 112/346 (32%), Positives = 160/346 (46%), Gaps = 8/346 (2%)
Query: 68 PGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSV 127
P P A G CPA C C+ A V C+ R LT +PDG+P T+ L L N + +
Sbjct: 16 PAAPPPAGG--CPARCECTVQTRA----VACTRRRLTAVPDGIPAETRLLELSRNRIRCL 69
Query: 128 PPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALA 187
P L +L L+L + +EP A L L L L NQL+ + G F L
Sbjct: 70 NPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLT 129
Query: 188 SLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYL 247
L LS N+L L D F+ L SL L +G N L + AF GL +L EL L L L
Sbjct: 130 LLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTAL 189
Query: 248 QPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDR-NLIAAVAPGAFLGLKAL 306
L L L L A+ +++ F +LP L L +D L+ VA G+ GL L
Sbjct: 190 SGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGLN-L 248
Query: 307 RWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQ 366
L ++H + + L L LSHN I+++ +F+DL L EL L +
Sbjct: 249 TSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAV 308
Query: 367 LAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL 412
+ ++F GL Q+ +L L +N L ++ F + + + + GN L
Sbjct: 309 VEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPL 354
Score = 120 bits (302), Expect = 3e-27
Identities = 115/384 (29%), Positives = 176/384 (45%), Gaps = 42/384 (10%)
Query: 256 AELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNR 315
AE R L+LSRN +R + LP L++L L N IA V PGAF L LR L L N+
Sbjct: 54 AETRLLELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQ 113
Query: 316 VAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGL 375
+ + F L L +L LS N + L TF+DLH L L++G N + ++ R+F GL
Sbjct: 114 LKLIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGL 173
Query: 376 GQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEG-S 434
LE LTL+ L + + L ++ + L + +L +Q FR L L L ++
Sbjct: 174 LALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWP 233
Query: 435 CLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQG 494
L + + GL+ L L + + + +L A L L+L+ N ++ +P F+
Sbjct: 234 LLEEVAAGSLRGLN-LTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRD 292
Query: 495 LGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNN 554
L +L L L+ LA + A L++ L++S+N L L S +
Sbjct: 293 LVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTF-------------H 339
Query: 555 SLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAY 614
S+ T LE L ++GNP C C L + +Q + D + PA
Sbjct: 340 SVNT-------LETLRVDGNPLACDCRLL----WIVQRRKTL---------NFDGRLPA- 378
Query: 615 TYNNITCASPPEVVGLDLRDLSEA 638
CA+P EV G LR+L ++
Sbjct: 379 ------CATPAEVRGDALRNLPDS 396
Score = 80.1 bits (196), Expect = 6e-15
Identities = 56/179 (31%), Positives = 89/179 (49%)
Query: 115 QALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRS 174
+ L L+ NL+++ + +L SLG L L+ + SLE Q L L HL ++ L
Sbjct: 177 EELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLE 236
Query: 175 LALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSL 234
L SL +++ ++ + L LNL N ++ +P +FR L L
Sbjct: 237 EVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRL 296
Query: 235 RELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIA 293
REL LAG LA ++P F GL ++R L+LS N L ++ + F + L+ L +D N +A
Sbjct: 297 RELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLA 355
>gi|4507531 toll-like receptor 3 [Homo sapiens]
Length = 904
Score = 144 bits (363), Expect = 2e-34
Identities = 145/526 (27%), Positives = 236/526 (44%), Gaps = 59/526 (11%)
Query: 98 CSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALL 157
CS LT++PD +P L L N L +P A F S L L++ + LEP+
Sbjct: 37 CSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQ 96
Query: 158 GLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGW 217
L L L+L+ N+L L+ TFA L L L +N + ++++ F +L L+L
Sbjct: 97 KLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSH 156
Query: 218 NSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPA---LFSGLAELRELDLSRNALRAIKAN 274
N L+ L +L+EL+L+ N++ L+ +F+ + L++L+LS N ++
Sbjct: 157 NGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFAN-SSLKKLELSSNQIKEFSPG 215
Query: 275 VFVQLPRLQKLYLD---------------------RNL------IAAVAPGAFLGLK--A 305
F + RL L+L+ RNL ++ + FLGLK
Sbjct: 216 CFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTN 275
Query: 306 LRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIR 365
L LDLS+N + + D+F L L L +N I L + L + L L + +
Sbjct: 276 LTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTK 335
Query: 366 Q---------LAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN--CLRN 414
Q + + SF+ L LE L ++ N + +K+ F GL N+ ++LS + LR
Sbjct: 336 QSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRT 395
Query: 415 LPEQVFRGL--GKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL-VGIEEQSLWGL 471
L + F L LH L+L + + +I F+ L L L L N + + Q GL
Sbjct: 396 LTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGL 455
Query: 472 AELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPA--DALGPLQRAFWLDVSH 529
+ E+ L+ N+ L F + L+ L+L R L + + PL+ LD+S+
Sbjct: 456 ENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSN 515
Query: 530 NRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNP 575
N + + + +L L +L L L++N+ L RLW NP
Sbjct: 516 NNIANINDDMLEGLEKLEILDLQHNN----------LARLWKHANP 551
Score = 141 bits (356), Expect = 2e-33
Identities = 154/553 (27%), Positives = 234/553 (42%), Gaps = 79/553 (14%)
Query: 91 ADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGS 150
+D+ FC+ NLT L L N++ + F +L L+L L S
Sbjct: 115 SDKTFAFCT--NLTELH-----------LMSNSIQKIKNNPFVKQKNLITLDLSHNGLSS 161
Query: 151 LEPQALLGLENLCHLHLERNQLRSLA---LGTFAHTPALASLGLSNNRLSRLEDGLFEGL 207
+ + LENL L L N++++L L FA++ +L L LS+N++ G F +
Sbjct: 162 TKLGTQVQLENLQELLLSNNKIQALKSEELDIFANS-SLKKLELSSNQIKEFSPGCFHAI 220
Query: 208 GSLWDLNLGWNSLAVLPDAAFR-----GLGSLRELVLAGNRLAYLQPALFSGL--AELRE 260
G L+ L L N++ + P + S+R L L+ ++L+ F GL L
Sbjct: 221 GRLFGLFL--NNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTM 278
Query: 261 LDLSRNALRAIKANVFVQLPRLQKLYLDRNLIA--------------------------- 293
LDLS N L + + F LP+L+ +L+ N I
Sbjct: 279 LDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSI 338
Query: 294 ------AVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHN--AIASLRP 345
+ +F LK L L++ N + G+ + F GL+ L+ L LS++ ++ +L
Sbjct: 339 SLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTN 398
Query: 346 RTFKDLHF--LEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQL-QEVKAGAFLGLTNV 402
TF L L L L N+I ++ +F LG LEVL L N++ QE+ + GL N+
Sbjct: 399 ETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENI 458
Query: 403 AVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRI--RPHTFTGLSGLRRLFLKDNGL 460
+ LS N L F + L L L L + P F L L L L +N +
Sbjct: 459 FEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNI 518
Query: 461 VGIEEQSLWGLAELLELDLTSNQLTHL--------PHRLFQGLGKLEYLLLSRNRLAELP 512
I + L GL +L LDL N L L P +GL L L L N E+P
Sbjct: 519 ANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIP 578
Query: 513 ADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSL-----RTFTPQPPGLE 567
+ L +D+ N L LP S+ L+ L+L+ N + + F P L
Sbjct: 579 VEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLT 638
Query: 568 RLWLEGNPWDCGC 580
L + NP+DC C
Sbjct: 639 ELDMRFNPFDCTC 651
Score = 116 bits (290), Expect = 7e-26
Identities = 122/429 (28%), Positives = 184/429 (42%), Gaps = 47/429 (10%)
Query: 136 SSLGFLNLQGGQLGSLEPQALLGLE--NLCHLHLERNQLRSLALGTFAHTPALASLGLSN 193
+S+ L+L QL + LGL+ NL L L N L + +FA P L L
Sbjct: 248 TSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEY 307
Query: 194 NRLSRLEDGLFEGLGSLWDLNLGWN------SLAVLP---DAAFRGLGSLRELVLAGNRL 244
N + L GL ++ LNL + SLA LP D +F+ L L L + N +
Sbjct: 308 NNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDI 367
Query: 245 AYLQPALFSGLAELRELDLSRN--ALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLG 302
++ +F+GL L+ L LS + +LR + FV L
Sbjct: 368 PGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAH--------------------- 406
Query: 303 LKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIAS-LRPRTFKDLHFLEELQLGH 361
L L+L+ N+++ + D F L L VL L N I L + ++ L + E+ L +
Sbjct: 407 -SPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSY 465
Query: 362 NRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGA--FLGLTNVAVMNLSGNCLRNLPEQV 419
N+ QL SF + L+ L L L+ V + F L N+ +++LS N + N+ + +
Sbjct: 466 NKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDM 525
Query: 420 FRGLGKLHSLHLEGSCLGRIRPHT--------FTGLSGLRRLFLKDNGLVGIEEQSLWGL 471
GL KL L L+ + L R+ H GLS L L L+ NG I + L
Sbjct: 526 LEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDL 585
Query: 472 AELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFW-LDVSHN 530
EL +DL N L LP +F L+ L L +N + + GP R LD+ N
Sbjct: 586 FELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFN 645
Query: 531 RLEALPNSL 539
+ S+
Sbjct: 646 PFDCTCESI 654
>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
sapiens]
Length = 593
Score = 143 bits (360), Expect = 6e-34
Identities = 131/385 (34%), Positives = 179/385 (46%), Gaps = 39/385 (10%)
Query: 36 PPQASPPAGGLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELS 95
P QA PP L LLL PG G +CPA C C+ A
Sbjct: 7 PKQAWPPWPPLLFLLLL------------------PG-GSGGSCPAVCDCTSQPQA---- 43
Query: 96 VFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQA 155
V C R L +P G+P T+ L L GN L + LS L L+L QL +LEP A
Sbjct: 44 VLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGA 103
Query: 156 LLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNL 215
GL++L L L+ N+LR + G F+ AL L L N++ DG F LGSL L +
Sbjct: 104 FHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEV 163
Query: 216 GWNSLAVLPDAAFRGLGSLRELVL--------AGNRLAYLQPALFSGLAELRELDLSRNA 267
G N L + AF GL L L L G LA L PAL + LRELD+ R
Sbjct: 164 GDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARL-PALVA--LRLRELDIGRLP 220
Query: 268 LRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGL 327
A++ QL L+ ++L +L A+ PG+ +GL L L ++ ++ + L
Sbjct: 221 AGALRG--LGQLKELE-IHLWPSL-EALDPGSLVGLN-LSSLAITRCNLSSVPFQALYHL 275
Query: 328 LGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQ 387
LRVL LS N I+++ R L L+EL+L + +A +F GL +L + N
Sbjct: 276 SFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNA 335
Query: 388 LQEVKAGAFLGLTNVAVMNLSGNCL 412
LQ ++ AF + + LSGN L
Sbjct: 336 LQTLEETAFPSPDKLVTLRLSGNPL 360
Score = 137 bits (344), Expect = 4e-32
Identities = 108/301 (35%), Positives = 146/301 (48%), Gaps = 8/301 (2%)
Query: 189 LGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQ 248
L LS NRL L+ G+ L L +L+L +N L+ L AF GL SL L L GNRL +
Sbjct: 65 LDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMG 124
Query: 249 PALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRW 308
P +FSGL+ L LDL N + F +L LQKL + N + VAPGAF GL L
Sbjct: 125 PGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLST 184
Query: 309 LDLSH---NRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLG-HNRI 364
L L + V GL P L+ LR+ L I L + L L+EL++ +
Sbjct: 185 LTLERCNLSTVPGLALARLPALVALRLRELD---IGRLPAGALRGLGQLKELEIHLWPSL 241
Query: 365 RQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLG 424
L S GL L L + L V A L+ + V++LS N + +P + L
Sbjct: 242 EALDPGSLVGL-NLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLV 300
Query: 425 KLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQL 484
+L L L G+CL I H F GL+ L + DN L +EE + +L+ L L+ N L
Sbjct: 301 RLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPL 360
Query: 485 T 485
T
Sbjct: 361 T 361
Score = 94.7 bits (234), Expect = 2e-19
Identities = 101/356 (28%), Positives = 149/356 (41%), Gaps = 63/356 (17%)
Query: 322 DTFPGLLGL--RVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLE 379
+ PG L L +L LS N + L+ L L+EL L +N++ L +F GL L
Sbjct: 52 EAVPGGLPLDTELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLL 111
Query: 380 VLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRI 439
L L N+L+ + G F GL+ + +++L N + + F LG L L + + L +
Sbjct: 112 TLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFV 171
Query: 440 RPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLE 499
P F GL+ L L L+ L + +L L L+ L L + LP +GLG+L+
Sbjct: 172 APGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLK 231
Query: 500 ------------------------YLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEAL 535
L ++R L+ +P AL L LD+S N + A+
Sbjct: 232 ELEIHLWPSLEALDPGSLVGLNLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAI 291
Query: 536 PNSLLAPLGRLRYLSL------------------------RNNSLRTFT----PQPPGLE 567
P L+PL RL+ L L +N+L+T P P L
Sbjct: 292 PARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLV 351
Query: 568 RLWLEGNPWDCGCPLKAL------RDFALQNPS-AVPRFVQ--AICEGDDCQPPAY 614
L L GNP C C L L DF + P+ A P VQ ++ E D PP +
Sbjct: 352 TLRLSGNPLTCDCRLLWLLRLRRHLDFGMSPPACAGPHHVQGKSLKEFSDILPPGH 407
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 142 bits (359), Expect = 7e-34
Identities = 103/314 (32%), Positives = 155/314 (49%), Gaps = 1/314 (0%)
Query: 98 CSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALL 157
C + L+ +P P T L+L GNN+S + + L SL L L + + P+A +
Sbjct: 46 CRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFV 105
Query: 158 GLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGW 217
L +L L L N ++ L G F L +L L N++S + G+F L S+ LNL
Sbjct: 106 QLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQR 165
Query: 218 NSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFV 277
N L VL F G+ +LR L L+ N + + + F L L L L N L + +N F
Sbjct: 166 NRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFE 225
Query: 278 QLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSH 337
L L++L L N I A+ P AF GL L +L L ++R+ + D F G+ L+ L LSH
Sbjct: 226 VLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSH 285
Query: 338 NAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLG-QLEVLTLDHNQLQEVKAGAF 396
N + +L TF L L L+L NRI + +FE +G L++L L N L +
Sbjct: 286 NDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVL 345
Query: 397 LGLTNVAVMNLSGN 410
L+++ + + N
Sbjct: 346 KPLSSLIHLQANSN 359
Score = 142 bits (358), Expect = 9e-34
Identities = 111/374 (29%), Positives = 163/374 (43%), Gaps = 42/374 (11%)
Query: 261 LDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLL 320
L L+ N + I + L L LYLD + I V P AF+ L+ L +L L++N + L
Sbjct: 65 LYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLD 124
Query: 321 EDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEV 380
F GLL LR L L +N ++ + F DL ++ L L NR+ L +F G+ L +
Sbjct: 125 PGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRI 184
Query: 381 LTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIR 440
L L +N + + F L N+A + L N L +P F L L L L + + I+
Sbjct: 185 LDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQ 244
Query: 441 PHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEY 500
P F GL+ L L LK++ + + G+ L L L+ N L +L F L L Y
Sbjct: 245 PFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIY 304
Query: 501 LLLSRNRLAELPADALGPLQRAF-WLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTF 559
L L RNR+ + D + + L++S N L AL +L PL L +L +
Sbjct: 305 LKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANS------ 358
Query: 560 TPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNI 619
NPW+C C L LRD+ + + NI
Sbjct: 359 --------------NPWECNCKLLGLRDWLASSAITL---------------------NI 383
Query: 620 TCASPPEVVGLDLR 633
C +PP + G LR
Sbjct: 384 YCQNPPSMRGRALR 397
Score = 135 bits (341), Expect = 9e-32
Identities = 93/295 (31%), Positives = 151/295 (51%), Gaps = 1/295 (0%)
Query: 213 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 272
L L N+++ + ++ GL SL L L + + Y+ P F L L L L+ N ++ +
Sbjct: 65 LYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLD 124
Query: 273 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRV 332
+F L L+ LYL N ++ V G F L ++++L+L NR+ L TF G++ LR+
Sbjct: 125 PGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRI 184
Query: 333 LRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVK 392
L LS+N I + F+ L L L LG N + ++ +FE L L L+L HN ++ ++
Sbjct: 185 LDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQ 244
Query: 393 AGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRR 452
AF GL N+ + L + +RN+ F G+ L L L + L + TF+ L L
Sbjct: 245 PFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIY 304
Query: 453 LFLKDNGLVGIEEQSLWGL-AELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRN 506
L L N ++ I+ + + A L L+L+ N LT L R+ + L L +L + N
Sbjct: 305 LKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSN 359
Score = 134 bits (337), Expect = 3e-31
Identities = 105/331 (31%), Positives = 155/331 (46%), Gaps = 4/331 (1%)
Query: 156 LLGLENLCHLHLERN-QLRSLALGTFAHT--PALASLGLSNNRLSRLEDGLFEGLGSLWD 212
+LG ++C L R R+L L + + L L+ N +S + + GL SL
Sbjct: 29 ILGCSSVCQLCTGRQINCRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHSLVA 88
Query: 213 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 272
L L +++ + AF L L L L N + L P +F GL LR L L N + +
Sbjct: 89 LYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVP 148
Query: 273 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRV 332
VF L +Q L L RN + + G F+G+ ALR LDLS+N + + E F L L
Sbjct: 149 RGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLAC 208
Query: 333 LRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVK 392
L L N + + F+ L L L L HN I + +F+GL LE L L +++++ V
Sbjct: 209 LYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVT 268
Query: 393 AGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGL-SGLR 451
F G+ N+ + LS N L NL F L L L L+ + + I TF + + L+
Sbjct: 269 RDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLK 328
Query: 452 RLFLKDNGLVGIEEQSLWGLAELLELDLTSN 482
L L N L + + L L+ L+ L SN
Sbjct: 329 ILNLSFNNLTALHPRVLKPLSSLIHLQANSN 359
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 140 bits (354), Expect = 3e-33
Identities = 130/364 (35%), Positives = 176/364 (48%), Gaps = 12/364 (3%)
Query: 169 RNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAF 228
R+ LR L L P + L + +L L LG + LNLG N L +P+
Sbjct: 26 RSNLRQLTLTAAGACPGAGADALESPASPQLV--LPANLGDIEALNLGNNGLEEVPEGLG 83
Query: 229 RGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLD 288
LGSLR LVL NR A L PA+ L ELD+S N L A+ A V L L+KL L
Sbjct: 84 SALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGAEVVSALRELRKLNLS 143
Query: 289 RNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTF 348
N + A+ P L L LD+S NR+A L D+ L LR L + HN + + PR
Sbjct: 144 HNQLPAL-PAQLGALAHLEELDVSFNRLAH-LPDSLSCLSRLRTLDVDHNQLTAF-PRQL 200
Query: 349 KDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLS 408
L LEEL + NR+R L E L L++L L +L + AG F L ++ + L
Sbjct: 201 LQLVALEELDVSSNRLRGLPE-DISALRALKILWLSGAELGTLPAG-FCELASLESLMLD 258
Query: 409 GNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSL 468
N L+ LP Q F L +L L+L + P L+GL L+L N L + +
Sbjct: 259 NNGLQALPAQ-FSCLQRLKMLNLSSNLFEEF-PAALLPLAGLEELYLSRNQLTSV-PSLI 315
Query: 469 WGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVS 528
GL LL L L +N++ +LP + + G LE L+L N++A LP D G L R +
Sbjct: 316 SGLGRLLTLWLDNNRIRYLPDSIVELTG-LEELVLQGNQIAVLP-DHFGQLSRVGLWKIK 373
Query: 529 HNRL 532
N L
Sbjct: 374 DNPL 377
Score = 117 bits (292), Expect = 4e-26
Identities = 114/331 (34%), Positives = 154/331 (46%), Gaps = 37/331 (11%)
Query: 248 QPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALR 307
Q L + L ++ L+L N L + + L L+ L L RN A + P L
Sbjct: 55 QLVLPANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLT 114
Query: 308 WLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQL 367
LD+SHNR+ L + L LR L LSHN + +L P L LEEL + NR+ L
Sbjct: 115 ELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPAL-PAQLGALAHLEELDVSFNRLAHL 173
Query: 368 AERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLH 427
+ S L +L L +DHNQL L L + +++S N LR LPE + L L
Sbjct: 174 PD-SLSCLSRLRTLDVDHNQLTAFPR-QLLQLVALEELDVSSNRLRGLPEDI-SALRALK 230
Query: 428 SLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHL 487
L L G+ LG + P F L+ L L L +NGL + Q
Sbjct: 231 ILWLSGAELGTL-PAGFCELASLESLMLDNNGLQALPAQ--------------------- 268
Query: 488 PHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLR 547
F L +L+ L LS N E PA AL PL L +S N+L ++P SL++ LGRL
Sbjct: 269 ----FSCLQRLKMLNLSSNLFEEFPA-ALLPLAGLEELYLSRNQLTSVP-SLISGLGRLL 322
Query: 548 YLSLRNNSLRTFTP----QPPGLERLWLEGN 574
L L NN +R + P + GLE L L+GN
Sbjct: 323 TLWLDNNRIR-YLPDSIVELTGLEELVLQGN 352
Score = 91.7 bits (226), Expect = 2e-18
Identities = 106/334 (31%), Positives = 144/334 (43%), Gaps = 38/334 (11%)
Query: 112 GGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQ 171
G +AL L N L VP L SL L L+ + L P +L L + N+
Sbjct: 63 GDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNR 122
Query: 172 LRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGL 231
L +L + L L LS+N+L L L L L +L++ +N LA LPD + L
Sbjct: 123 LTALGAEVVSALRELRKLNLSHNQLPALPAQL-GALAHLEELDVSFNRLAHLPD-SLSCL 180
Query: 232 GSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANV---------------- 275
LR L + N+L P L L ELD+S N LR + ++
Sbjct: 181 SRLRTLDVDHNQLTAF-PRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAEL 239
Query: 276 ------FVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPG--- 326
F +L L+ L LD N + A+ P F L+ L+ L+LS N L + FP
Sbjct: 240 GTLPAGFCELASLESLMLDNNGLQAL-PAQFSCLQRLKMLNLSSN-----LFEEFPAALL 293
Query: 327 -LLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDH 385
L GL L LS N + S+ P L L L L +NRIR L + E G LE L L
Sbjct: 294 PLAGLEELYLSRNQLTSV-PSLISGLGRLLTLWLDNNRIRYLPDSIVELTG-LEELVLQG 351
Query: 386 NQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQV 419
NQ+ V F L+ V + + N L P +V
Sbjct: 352 NQI-AVLPDHFGQLSRVGLWKIKDNPLIQPPYEV 384
Score = 77.4 bits (189), Expect = 4e-14
Identities = 71/201 (35%), Positives = 92/201 (45%), Gaps = 10/201 (4%)
Query: 399 LTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDN 458
L ++ +NL N L +PE + LG L L L + R+ P L L + N
Sbjct: 62 LGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHN 121
Query: 459 GLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGP 518
L + + + L EL +L+L+ NQL LP +L L LE L +S NRLA LP D+L
Sbjct: 122 RLTALGAEVVSALRELRKLNLSHNQLPALPAQL-GALAHLEELDVSFNRLAHLP-DSLSC 179
Query: 519 LQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLER---LWLEG-- 573
L R LDV HN+L A P LL L L L + +N LR L LWL G
Sbjct: 180 LSRLRTLDVDHNQLTAFPRQLL-QLVALEELDVSSNRLRGLPEDISALRALKILWLSGAE 238
Query: 574 -NPWDCG-CPLKALRDFALQN 592
G C L +L L N
Sbjct: 239 LGTLPAGFCELASLESLMLDN 259
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 140 bits (353), Expect = 4e-33
Identities = 120/421 (28%), Positives = 197/421 (46%), Gaps = 36/421 (8%)
Query: 191 LSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPA 250
LS+NRLS ++ L SL ++ L N L +P+ ++ L LAGNR+ + P
Sbjct: 21 LSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS-ANITLLSLAGNRIVEILPE 79
Query: 251 LFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLD 310
L LDLS N + ++ F L +L+ LYL+ N + ++ PG F L
Sbjct: 80 HLKEFQSLETLDLSSNNISELQT-AFPAL-QLKYLYLNSNRVTSMEPGYFDNLANT---- 133
Query: 311 LSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAER 370
L VL+L+ N I+++ P+ FK L L+ L+L N+I+ +
Sbjct: 134 -------------------LLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGL 173
Query: 371 SFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLH 430
+F+GLG L+ L + N + ++ GAF GL+N+ ++ L N L + + GL L LH
Sbjct: 174 TFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELH 233
Query: 431 LEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHR 490
L + + RI P + L L L N L +++ S GL+ L L + +N+++++
Sbjct: 234 LSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADC 293
Query: 491 LFQGLGKLEYLLLSRNRLAELPAD---ALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLR 547
F+GL L+ L L N ++ D A L + L + NR+ ++ L L
Sbjct: 294 AFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALE 353
Query: 548 YLSLRNNSLRTFT----PQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAI 603
+L L +N++ + Q L++L L + C C LK L + +N FV A
Sbjct: 354 HLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAEN--NFQSFVNAS 411
Query: 604 C 604
C
Sbjct: 412 C 412
Score = 138 bits (347), Expect = 2e-32
Identities = 114/369 (30%), Positives = 180/369 (48%), Gaps = 30/369 (8%)
Query: 167 LERNQLRSLALGTFAHTPALASLGLSNNRL--------------------SRLEDGLFEG 206
L N+L + + +H +L + L+NN L +R+ + L E
Sbjct: 21 LSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEH 80
Query: 207 L---GSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAE-LRELD 262
L SL L+L N+++ L AF L L+ L L NR+ ++P F LA L L
Sbjct: 81 LKEFQSLETLDLSSNNISEL-QTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLK 138
Query: 263 LSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLED 322
L+RN + AI +F +LP+LQ L L+RN I V F GL AL+ L + N V L++
Sbjct: 139 LNRNRISAIPPKMF-KLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDG 197
Query: 323 TFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLT 382
F GL + +L+L HN + + L L+EL L N I +++ ++E +L L
Sbjct: 198 AFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELD 257
Query: 383 LDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLG---RI 439
L N L + +FLGL+ + +++ N + + + FRGL L +L L+ + +
Sbjct: 258 LTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIED 317
Query: 440 RPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLE 499
F+GL LRRL L+ N + I +++ GL L LDL+ N + L F + KL+
Sbjct: 318 MNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQ 377
Query: 500 YLLLSRNRL 508
L L+ + L
Sbjct: 378 QLHLNTSSL 386
Score = 134 bits (337), Expect = 3e-31
Identities = 97/295 (32%), Positives = 155/295 (52%), Gaps = 6/295 (2%)
Query: 99 SSRNLTRLPDGVPG-GTQALWLDGNNLSSVPPAAFQNLSS-LGFLNLQGGQLGSLEPQAL 156
SS N++ L P + L+L+ N ++S+ P F NL++ L L L ++ ++ P+ +
Sbjct: 93 SSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPK-M 151
Query: 157 LGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLG 216
L L HL L RN+++++ TF AL SL + N +++L DG F GL ++ L L
Sbjct: 152 FKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLD 211
Query: 217 WNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVF 276
N+L + GL L+EL L+ N + + P + +L ELDL+ N L + + F
Sbjct: 212 HNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSF 271
Query: 277 VQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLED---TFPGLLGLRVL 333
+ L L L++ N ++ +A AF GL +L+ LDL +N ++ +ED F GL LR L
Sbjct: 272 LGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRL 331
Query: 334 RLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQL 388
L N I S+ + F L LE L L N I L +F + +L+ L L+ + L
Sbjct: 332 ILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 386
Score = 97.1 bits (240), Expect = 5e-20
Identities = 79/269 (29%), Positives = 127/269 (47%), Gaps = 27/269 (10%)
Query: 310 DLSHNRVAGLLEDTFPGLLGLR-----------------------VLRLSHNAIASLRPR 346
DLSHNR++ + + L LR +L L+ N I + P
Sbjct: 20 DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPE 79
Query: 347 TFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTN-VAVM 405
K+ LE L L N I +L + +F L QL+ L L+ N++ ++ G F L N + V+
Sbjct: 80 HLKEFQSLETLDLSSNNISEL-QTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVL 137
Query: 406 NLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEE 465
L+ N + +P ++F+ L +L L L + + + TF GL L+ L ++ NG+ + +
Sbjct: 138 KLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMD 196
Query: 466 QSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWL 525
+ WGL+ + L L N LT + GL L+ L LS+N + + DA Q+ L
Sbjct: 197 GAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSEL 256
Query: 526 DVSHNRLEALPNSLLAPLGRLRYLSLRNN 554
D++ N L L +S L L L + NN
Sbjct: 257 DLTFNHLSRLDDSSFLGLSLLNTLHIGNN 285
Score = 58.9 bits (141), Expect = 1e-08
Identities = 55/237 (23%), Positives = 100/237 (42%), Gaps = 31/237 (13%)
Query: 351 LHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLG--LTNVAVMNLS 408
L + L HNR+ + S L L + L++N+L+ + LG N+ +++L+
Sbjct: 13 LFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPN---LGPVSANITLLSLA 69
Query: 409 GNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIE---- 464
GN + + + + L +L L + + ++ F L L+ L+L N + +E
Sbjct: 70 GNRIVEILPEHLKEFQSLETLDLSSNNISELQT-AFPALQ-LKYLYLNSNRVTSMEPGYF 127
Query: 465 --------------------EQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLS 504
++ L +L L+L N++ ++ FQGLG L+ L +
Sbjct: 128 DNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQ 187
Query: 505 RNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTP 561
RN + +L A L L + HN L + L L L+ L L N++ +P
Sbjct: 188 RNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISP 244
Score = 32.0 bits (71), Expect = 1.8
Identities = 20/52 (38%), Positives = 26/52 (50%), Gaps = 3/52 (5%)
Query: 526 DVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFT---PQPPGLERLWLEGN 574
D+SHNRL + S ++ L LR + L NN L T P + L L GN
Sbjct: 20 DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGN 71
>gi|45505137 podocan [Homo sapiens]
Length = 661
Score = 140 bits (352), Expect = 5e-33
Identities = 156/531 (29%), Positives = 238/531 (44%), Gaps = 63/531 (11%)
Query: 63 LEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGN 122
L +PG PG A +CP C CS + D C +L P +P T L L N
Sbjct: 102 LSPEEPG-PGPA-AVSCPRDCACSQEGVVD-----CGGIDLREFPGDLPEHTNHLSLQNN 154
Query: 123 NLSSVPPAAFQNLSSLGFLNLQGGQLGS--LEPQALLGLENLCHLHLERNQLRSLALGTF 180
L + P L L LNLQ +L S L +A L NL +L+L N+L L
Sbjct: 155 QLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKL---TLAPR 211
Query: 181 AHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAV--LPDAAFRGLGSLRELV 238
AL S+ + N L+++ F +L + L N LA LPD F G ++ L+
Sbjct: 212 FLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLI 271
Query: 239 LAGNRLAY----LQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIA- 293
L+ N L + L PAL+ +L L N L I F +L L++LYL N +
Sbjct: 272 LSSNFLRHVPKHLPPALY-------KLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTD 324
Query: 294 -AVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLH 352
+ F L +L +LDLS N ++ + L+ +L L NAI S+ +
Sbjct: 325 EGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLV---LLHLEKNAIRSVDANVLTPIR 381
Query: 353 FLEELQLGHNRIRQ--LAERSFEGLGQLEVLTLDHNQLQEVKAG---------------A 395
LE L L N++R+ + +F+GL +L + L +N L+ V +G
Sbjct: 382 SLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQIT 441
Query: 396 FLGLTNVAV------MNLSGNCLRN--LPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGL 447
+G + A +NLS N + + + FR L L SL L G+ L + P +
Sbjct: 442 GIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNV 501
Query: 448 SGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTH--LPHRLFQGLGKLEYLLLSR 505
L+ +K N L + +L G+A+L EL LTSN+L L R + L L+ L ++
Sbjct: 502 HVLK---VKRNELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAG 558
Query: 506 NRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSL 556
N+L E+P L+ +L + +N++ A+P + L+ + LR N L
Sbjct: 559 NQLTEIPEGLPESLE---YLYLQNNKISAVPANAFDSTPNLKGIFLRFNKL 606
Score = 109 bits (273), Expect = 7e-24
Identities = 116/394 (29%), Positives = 178/394 (45%), Gaps = 46/394 (11%)
Query: 99 SSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLG 158
SS L +P +P L L N L +PP AF LSSL L LQ L G
Sbjct: 273 SSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTD------EG 326
Query: 159 LENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWN 218
L+N TF +L L LS+N LSR+ GL SL L+L N
Sbjct: 327 LDN----------------ETFWKLSSLEYLDLSSNNLSRVPAGLPR---SLVLLHLEKN 367
Query: 219 SLAVLPDAAFRGLGSLRELVLAGNRLAY--LQPALFSGLAELRELDLSRNALRAIKANVF 276
++ + + SL L+L N+L + P F GL L + L NAL + +
Sbjct: 368 AIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSG-- 425
Query: 277 VQLP-RLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAG--LLEDTFPGLLGLRVL 333
LP R++ L + N I + F L L+LS+NR+ + D F L LR L
Sbjct: 426 --LPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSL 483
Query: 334 RLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKA 393
LS N + +L P +++H L++ N + LA + G+ QL L L N+L+
Sbjct: 484 DLSGNRLHTLPPGLPRNVHV---LKVKRNELAALARGALVGMAQLRELYLTSNRLRSRAL 540
Query: 394 G--AFLGLTNVAVMNLSGNCLRNLPEQVFRGLGK-LHSLHLEGSCLGRIRPHTFTGLSGL 450
G A++ L ++ +++++GN L +PE GL + L L+L+ + + + + F L
Sbjct: 541 GPRAWVDLAHLQLLDIAGNQLTEIPE----GLPESLEYLYLQNNKISAVPANAFDSTPNL 596
Query: 451 RRLFLKDNGLV--GIEEQSLWGLAELLELDLTSN 482
+ +FL+ N L + + + L L LD+ N
Sbjct: 597 KGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
Score = 97.4 bits (241), Expect = 4e-20
Identities = 90/292 (30%), Positives = 145/292 (49%), Gaps = 20/292 (6%)
Query: 285 LYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVA--GLLEDTFPGLLGLRVLRLSHNAIAS 342
L L N + + P L L L+L +NR+ GL E F L L L L++N + +
Sbjct: 149 LSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKL-T 207
Query: 343 LRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQE--VKAGAFLGLT 400
L PR + L + N + ++ +F L + L +N+L + + F G +
Sbjct: 208 LAPRFLPNA--LISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSS 265
Query: 401 NVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL 460
NV V+ LS N LR++P+ + L KLH L+ + L +I P F+ LS LR L+L++N L
Sbjct: 266 NVEVLILSSNFLRHVPKHLPPALYKLH---LKNNKLEKIPPGAFSELSSLRELYLQNNYL 322
Query: 461 V--GIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGP 518
G++ ++ W L+ L LDL+SN L+ +P L + L L L +N + + A+ L P
Sbjct: 323 TDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLH---LEKNAIRSVDANVLTP 379
Query: 519 LQRAFWLDVSHNRL--EALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLER 568
++ +L + N+L + + L RL + L NN+L P GL R
Sbjct: 380 IRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERV---PSGLPR 428
>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
sapiens]
Length = 606
Score = 136 bits (342), Expect = 7e-32
Identities = 103/334 (30%), Positives = 160/334 (47%), Gaps = 4/334 (1%)
Query: 79 CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSL 138
CPA C CS A SV C R L +P+G+P T+ L L N L SV P F + L
Sbjct: 28 CPARCECS----AQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLL 83
Query: 139 GFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSR 198
++L + ++EP A L NL L L+ N+L+ + LG F L L +S N++
Sbjct: 84 EEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVI 143
Query: 199 LEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAEL 258
L D +F+ L +L L +G N L + AF GL SL +L L L + S L L
Sbjct: 144 LLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSL 203
Query: 259 RELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAG 318
L L + + F +L L+ L +D + + P L L L +++ ++
Sbjct: 204 ISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLST 263
Query: 319 LLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQL 378
+ F L+ L L LS+N I+++ F DL L+EL + ++R + SF+GL L
Sbjct: 264 VPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFL 323
Query: 379 EVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL 412
VL + N L+ ++ F + V++++ N L
Sbjct: 324 RVLNVSQNLLETLEENVFSSPRALEVLSINNNPL 357
Score = 122 bits (305), Expect = 1e-27
Identities = 102/330 (30%), Positives = 150/330 (45%), Gaps = 28/330 (8%)
Query: 257 ELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRV 316
E + LDLS+N L+++ F+ P L+++ L N+IA V PGAF L LR L L NR+
Sbjct: 58 ETKILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRL 117
Query: 317 AGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLG 376
+ F GL L L +S N I L F+DLH L+ L++G N + ++ R+F GL
Sbjct: 118 KLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLL 177
Query: 377 QLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCL 436
LE LTL+ L V A L ++ ++L + N+P F+ L L L ++ L
Sbjct: 178 SLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPL 237
Query: 437 GRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLG 496
+ P SL+GL L L +T+ L+ +P F+ L
Sbjct: 238 LDMMP-----------------------ANSLYGL-NLTSLSVTNTNLSTVPFLAFKHLV 273
Query: 497 KLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSL 556
L +L LS N ++ + A L R L + +L + L LR L++ N L
Sbjct: 274 YLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLL 333
Query: 557 RTFTPQ----PPGLERLWLEGNPWDCGCPL 582
T P LE L + NP C C L
Sbjct: 334 ETLEENVFSSPRALEVLSINNNPLACDCRL 363
Score = 76.3 bits (186), Expect = 8e-14
Identities = 55/179 (30%), Positives = 92/179 (51%)
Query: 115 QALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRS 174
+ L L+ NL++VP A +L SL L+L+ + ++ A L +L HL ++ L
Sbjct: 180 EQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLD 239
Query: 175 LALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSL 234
+ + L SL ++N LS + F+ L L LNL +N ++ + F L L
Sbjct: 240 MMPANSLYGLNLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRL 299
Query: 235 RELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIA 293
+EL + G +L ++P F GL LR L++S+N L ++ NVF L+ L ++ N +A
Sbjct: 300 QELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLA 358
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 136 bits (342), Expect = 7e-32
Identities = 104/328 (31%), Positives = 163/328 (49%), Gaps = 7/328 (2%)
Query: 161 NLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSL 220
N+ L L N + + PAL SL LS+N +S ++ F + L LNL N +
Sbjct: 121 NITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRM-QLKYLNLSNNRI 179
Query: 221 AVLPDAAFRGLGS-LRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQL 279
L F L S L + L NR++ + P +F L L+ L+L RN ++ ++ F L
Sbjct: 180 TTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFK-LPHLQFLELKRNRIKIVEGLTFQGL 238
Query: 280 PRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNA 339
L+ L + RN I+ + GAF GL + L+L HN + + + GL L+ L +S NA
Sbjct: 239 DSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNA 298
Query: 340 IASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGL 399
I + P ++ L EL L +N++ +L E +F GL LE L L N++ + G F L
Sbjct: 299 IERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFL 358
Query: 400 TNVAVMNLSGNCLRNLPE---QVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLK 456
+N+ ++L N + E + F GL L L L+G+ + I F GL L L L
Sbjct: 359 SNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLN 418
Query: 457 DNGLVGIEEQSLWGLAELLELDLTSNQL 484
+N ++ I+E + + L EL L ++ L
Sbjct: 419 NNAIMSIQENA-FSQTHLKELILNTSSL 445
Score = 129 bits (324), Expect = 8e-30
Identities = 111/414 (26%), Positives = 194/414 (46%), Gaps = 34/414 (8%)
Query: 233 SLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLI 292
+L+E+ + N L + P + + L L N + I A P L+ L L N+I
Sbjct: 98 TLQEVKMNYNELTEI-PYFGEPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNII 156
Query: 293 AAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLG-LRVLRLSHNAIASLRPRTFKDL 351
+ + +F ++ L++L+LS+NR+ L F L L V++L+ N ++ + P+ FK
Sbjct: 157 SEIKTSSFPRMQ-LKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFKLP 215
Query: 352 HFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNC 411
H L+ L+L NRI+ + +F+GL L L + N + ++K GAF GL N+ + L N
Sbjct: 216 H-LQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNN 274
Query: 412 LRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGL 471
L + + GL L L++ + + RI P + L L L N L ++E + GL
Sbjct: 275 LTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGL 334
Query: 472 AELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLA---ELPADALGPLQRAFWLDVS 528
+ L L+L N++TH+ +F+ L L+ L L N ++ E ++A L L +
Sbjct: 335 SLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQ 394
Query: 529 HNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTP---QPPGLERLWLEGNPWDCGCPLKAL 585
N+++++ L L +L L NN++ + L+ L L + C C LK L
Sbjct: 395 GNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTHLKELILNTSSLLCDCHLKWL 454
Query: 586 RDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASP-----PEVVGLDLRD 634
+ + N F ++ N++CA P ++ +DL+D
Sbjct: 455 LQWLVDN-----NFQHSV--------------NVSCAHPEWLAGQSILNVDLKD 489
Score = 121 bits (304), Expect = 2e-27
Identities = 83/257 (32%), Positives = 129/257 (50%), Gaps = 3/257 (1%)
Query: 119 LDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALG 178
L N ++++ F NLSS + S+ P + L +L L L+RN+++ +
Sbjct: 174 LSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGL 233
Query: 179 TFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELV 238
TF +L SL + N +S+L+DG F GL ++ +L L N+L + GL L++L
Sbjct: 234 TFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLY 293
Query: 239 LAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPG 298
++ N + + P + L ELDLS N L + + FV L L++L L N + +A G
Sbjct: 294 VSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADG 353
Query: 299 AFLGLKALRWLDLSHNRVAGLLED---TFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLE 355
F L L+ LDL +N ++ +ED F GL L L L N I S+ + F L LE
Sbjct: 354 VFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLE 413
Query: 356 ELQLGHNRIRQLAERSF 372
L L +N I + E +F
Sbjct: 414 HLDLNNNAIMSIQENAF 430
Score = 104 bits (260), Expect = 2e-22
Identities = 72/213 (33%), Positives = 106/213 (49%), Gaps = 3/213 (1%)
Query: 115 QALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRS 174
Q L L N + V FQ L SL L +Q + L+ A GL N+ L LE N L
Sbjct: 218 QFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTR 277
Query: 175 LALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSL 234
+ G L L +S N + R+ +E L +L+L +N L L ++AF GL L
Sbjct: 278 VNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLL 337
Query: 235 RELVLAGNRLAYLQPALFSGLAELRELDLSRNALR-AIK--ANVFVQLPRLQKLYLDRNL 291
L L NR+ ++ +F L+ L+ LDL N + AI+ + F L L KL L N
Sbjct: 338 ERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQ 397
Query: 292 IAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTF 324
I ++ AF+GL++L LDL++N + + E+ F
Sbjct: 398 IKSITKKAFIGLESLEHLDLNNNAIMSIQENAF 430
Score = 45.1 bits (105), Expect = 2e-04
Identities = 33/87 (37%), Positives = 47/87 (54%), Gaps = 6/87 (6%)
Query: 103 LTRLPDGV---PGGTQALWLDGNNLS-SVPPA--AFQNLSSLGFLNLQGGQLGSLEPQAL 156
+T + DGV Q L L N +S ++ A AF L+SL L LQG Q+ S+ +A
Sbjct: 347 VTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAF 406
Query: 157 LGLENLCHLHLERNQLRSLALGTFAHT 183
+GLE+L HL L N + S+ F+ T
Sbjct: 407 IGLESLEHLDLNNNAIMSIQENAFSQT 433
>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
Length = 713
Score = 134 bits (336), Expect = 3e-31
Identities = 105/329 (31%), Positives = 145/329 (44%), Gaps = 31/329 (9%)
Query: 35 PPPQASPPAGGLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADEL 94
PP + S P G L L + G + G +CP AC CS
Sbjct: 13 PPGRMSWPHGALLFLWLFSPPLGAGGGGVAVTSAAGGGSPPATSCPVACSCSNQASR--- 69
Query: 95 SVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQ 154
V C+ R+L +P +P T+ L L N + + F++L L
Sbjct: 70 -VICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLEI-------------- 114
Query: 155 ALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLN 214
L L +N +R + +G F P+L +L L +NRL+ + FE L L +L
Sbjct: 115 ----------LQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELW 164
Query: 215 LGWNSLAVLPDAAFRGLGSLRELVLAG-NRLAYLQPALFSGLAELRELDLSRNALRAIKA 273
L N + +P AF + SLR L L RL Y+ A F GL LR L+L L+ I
Sbjct: 165 LRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPN 224
Query: 274 NVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVL 333
L RL++L L N + + PG+F GL +LR L L H +VA + + F L L L
Sbjct: 225 --LTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEEL 282
Query: 334 RLSHNAIASLRPRTFKDLHFLEELQLGHN 362
LSHN + SL F LH LE + L HN
Sbjct: 283 NLSHNNLMSLPHDLFTPLHRLERVHLNHN 311
Score = 111 bits (277), Expect = 2e-24
Identities = 84/249 (33%), Positives = 121/249 (48%), Gaps = 27/249 (10%)
Query: 259 RELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAG 318
R L+L N ++ I+ + F L L+ L L +NL+ + GAF GL +L L+L NR+
Sbjct: 89 RYLNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTT 148
Query: 319 LLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGH-NRIRQLAERSFEGLGQ 377
+ F L LR L L +N I S+ F + L L LG R+ ++E +FEGL
Sbjct: 149 VPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVN 208
Query: 378 LEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLG 437
L L LG+ N L+++P L +L L L G+ L
Sbjct: 209 LRYLN--------------LGMCN----------LKDIPN--LTALVRLEELELSGNRLD 242
Query: 438 RIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGK 497
IRP +F GL+ LR+L+L + IE + L L EL+L+ N L LPH LF L +
Sbjct: 243 LIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHR 302
Query: 498 LEYLLLSRN 506
LE + L+ N
Sbjct: 303 LERVHLNHN 311
Score = 107 bits (268), Expect = 3e-23
Identities = 85/252 (33%), Positives = 117/252 (46%), Gaps = 25/252 (9%)
Query: 331 RVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQE 390
R L L N I +R TFK L LE LQL N +R++ +F GL L L L N+L
Sbjct: 89 RYLNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTT 148
Query: 391 VKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHL-EGSCLGRIRPHTFTGLSG 449
V AF L+ + + L N + ++P F + L L L E L I F GL
Sbjct: 149 VPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVN 208
Query: 450 LRRLFLKDNGLVGIEE-QSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRL 508
LR L L G+ +++ +L L L EL+L+ N+L + FQGL L L L ++
Sbjct: 209 LRYLNL---GMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQV 265
Query: 509 AELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLER 568
A + +A L+ L++SHN L +LP+ L PL R LER
Sbjct: 266 ATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHR--------------------LER 305
Query: 569 LWLEGNPWDCGC 580
+ L NPW C C
Sbjct: 306 VHLNHNPWHCNC 317
>gi|13194201 reticulon 4 receptor precursor [Homo sapiens]
Length = 473
Score = 131 bits (329), Expect = 2e-30
Identities = 89/237 (37%), Positives = 125/237 (52%), Gaps = 4/237 (1%)
Query: 79 CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSL 138
CP ACVC Y++ +++ C + L +P G+P +Q ++L GN +S VP A+F+ +L
Sbjct: 27 CPGACVC-YNEP--KVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNL 83
Query: 139 GFLNLQGGQLGSLEPQALLGLENLCHLHLERN-QLRSLALGTFAHTPALASLGLSNNRLS 197
L L L ++ A GL L L L N QLRS+ TF L +L L L
Sbjct: 84 TILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQ 143
Query: 198 RLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAE 257
L GLF GL +L L L N+L LPD FR LG+L L L GNR++ + F GL
Sbjct: 144 ELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHS 203
Query: 258 LRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHN 314
L L L +N + + + F L RL LYL N ++A+ A L+AL++L L+ N
Sbjct: 204 LDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDN 260
Score = 126 bits (316), Expect = 7e-29
Identities = 81/232 (34%), Positives = 115/232 (49%), Gaps = 21/232 (9%)
Query: 355 EELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNC-LR 413
+ + L NRI + SF L +L L N L + A AF GL + ++LS N LR
Sbjct: 60 QRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLR 119
Query: 414 NLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAE 473
++ F GLG+LH+LHL+ L + P F GL+ L+ L+L+DN L + + + L
Sbjct: 120 SVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGN 179
Query: 474 LLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLE 533
L L L N+++ +P R F+GL L+ LLL +NR+A + A L R L + N L
Sbjct: 180 LTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLS 239
Query: 534 ALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKAL 585
ALP LAPL L+YL L + NPW C C + L
Sbjct: 240 ALPTEALAPLRALQYLRLND--------------------NPWVCDCRARPL 271
Score = 109 bits (273), Expect = 7e-24
Identities = 75/194 (38%), Positives = 104/194 (53%), Gaps = 1/194 (0%)
Query: 218 NSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNA-LRAIKANVF 276
N ++ +P A+FR +L L L N LA + A F+GLA L +LDLS NA LR++ F
Sbjct: 67 NRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATF 126
Query: 277 VQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLS 336
L RL L+LDR + + PG F GL AL++L L N + L +DTF L L L L
Sbjct: 127 HGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLH 186
Query: 337 HNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAF 396
N I+S+ R F+ LH L+ L L NR+ + +F LG+L L L N L + A
Sbjct: 187 GNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEAL 246
Query: 397 LGLTNVAVMNLSGN 410
L + + L+ N
Sbjct: 247 APLRALQYLRLNDN 260
Score = 91.3 bits (225), Expect = 3e-18
Identities = 68/201 (33%), Positives = 96/201 (47%), Gaps = 1/201 (0%)
Query: 283 QKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNA-IA 341
Q+++L N I+ V +F + L L L N +A + F GL L L LS NA +
Sbjct: 60 QRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLR 119
Query: 342 SLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTN 401
S+ P TF L L L L +++L F GL L+ L L N LQ + F L N
Sbjct: 120 SVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGN 179
Query: 402 VAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLV 461
+ + L GN + ++PE+ FRGL L L L + + + PH F L L L+L N L
Sbjct: 180 LTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLS 239
Query: 462 GIEEQSLWGLAELLELDLTSN 482
+ ++L L L L L N
Sbjct: 240 ALPTEALAPLRALQYLRLNDN 260
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.140 0.431
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,353,584
Number of Sequences: 37866
Number of extensions: 1375484
Number of successful extensions: 9214
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 208
Number of HSP's successfully gapped in prelim test: 106
Number of HSP's that attempted gapping in prelim test: 3785
Number of HSP's gapped (non-prelim): 2082
length of query: 643
length of database: 18,247,518
effective HSP length: 109
effective length of query: 534
effective length of database: 14,120,124
effective search space: 7540146216
effective search space used: 7540146216
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.