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Search of human proteins with 22538459
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo
sapiens]
(1440 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens] 2875 0.0
gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens] 2870 0.0
gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens] 2768 0.0
gi|5729858 nuclear receptor coactivator 2 [Homo sapiens] 587 e-167
gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens] 494 e-139
gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens] 494 e-139
gi|21614542 single-minded homolog 1 [Homo sapiens] 92 4e-18
gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Ho... 87 2e-16
gi|4758010 clock [Homo sapiens] 84 7e-16
gi|4827004 single-minded homolog 2 long isoform [Homo sapiens] 83 2e-15
gi|194239684 single-minded homolog 2 short isoform [Homo sapiens] 83 2e-15
gi|71852582 aryl hydrocarbon receptor nuclear translocator-like ... 81 6e-15
gi|71852580 aryl hydrocarbon receptor nuclear translocator-like ... 81 6e-15
gi|42716311 aryl hydrocarbon receptor nuclear translocator-like ... 81 6e-15
gi|22027471 neuronal PAS domain protein 2 [Homo sapiens] 79 2e-14
gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2 ... 74 8e-13
gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1 [... 74 8e-13
gi|30795242 aryl hydrocarbon receptor nuclear translocator isofo... 74 8e-13
gi|4502231 aryl hydrocarbon receptor nuclear translocator isofor... 74 8e-13
gi|31745180 aryl hydrocarbon receptor nuclear translocator-like ... 74 1e-12
gi|115430245 arylhydrocarbon receptor repressor [Homo sapiens] 73 2e-12
gi|30795240 aryl hydrocarbon receptor nuclear translocator isofo... 72 5e-12
gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens] 72 5e-12
gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a ... 70 1e-11
gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c ... 70 1e-11
gi|4502003 aryl hydrocarbon receptor [Homo sapiens] 70 2e-11
gi|22027482 neuronal PAS domain protein 1 [Homo sapiens] 69 4e-11
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 68 7e-11
gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b ... 68 7e-11
gi|40254439 endothelial PAS domain protein 1 [Homo sapiens] 67 9e-11
>gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens]
Length = 1440
Score = 2875 bits (7453), Expect = 0.0
Identities = 1440/1440 (100%), Positives = 1440/1440 (100%)
Query: 1 MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSL 60
MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSL
Sbjct: 1 MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSL 60
Query: 61 SVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEAL 120
SVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEAL
Sbjct: 61 SVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEAL 120
Query: 121 DGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNG 180
DGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNG
Sbjct: 121 DGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNG 180
Query: 181 VPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQ 240
VPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQ
Sbjct: 181 VPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQ 240
Query: 241 SCLICIARRLPRPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFF 300
SCLICIARRLPRPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFF
Sbjct: 241 SCLICIARRLPRPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFF 300
Query: 301 QPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMG 360
QPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMG
Sbjct: 301 QPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMG 360
Query: 361 IHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINR 420
IHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINR
Sbjct: 361 IHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINR 420
Query: 421 QQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTG 480
QQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTG
Sbjct: 421 QQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTG 480
Query: 481 ISLAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTS 540
ISLAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTS
Sbjct: 481 ISLAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTS 540
Query: 541 LQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDN 600
LQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDN
Sbjct: 541 LQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDN 600
Query: 601 SSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSC 660
SSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSC
Sbjct: 601 SSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSC 660
Query: 661 TGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVS 720
TGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVS
Sbjct: 661 TGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVS 720
Query: 721 VTGQVQGNSSIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQ 780
VTGQVQGNSSIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQ
Sbjct: 721 VTGQVQGNSSIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQ 780
Query: 781 MDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQFDQLLPTLEKAAQLPGLCETDRMDGAV 840
MDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQFDQLLPTLEKAAQLPGLCETDRMDGAV
Sbjct: 781 MDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQFDQLLPTLEKAAQLPGLCETDRMDGAV 840
Query: 841 TSVTIKSEILPASLQSATARPTSRLNRLPELELEAIDNQFGQPGTGDQIPWTNNTVTAIN 900
TSVTIKSEILPASLQSATARPTSRLNRLPELELEAIDNQFGQPGTGDQIPWTNNTVTAIN
Sbjct: 841 TSVTIKSEILPASLQSATARPTSRLNRLPELELEAIDNQFGQPGTGDQIPWTNNTVTAIN 900
Query: 901 QSKSEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKL 960
QSKSEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKL
Sbjct: 901 QSKSEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKL 960
Query: 961 VQGGGLDVLSERFPPQQATPPLIMEERPNLYSQPYSSPSPTANLPSPFQGMVRQKPSLGT 1020
VQGGGLDVLSERFPPQQATPPLIMEERPNLYSQPYSSPSPTANLPSPFQGMVRQKPSLGT
Sbjct: 961 VQGGGLDVLSERFPPQQATPPLIMEERPNLYSQPYSSPSPTANLPSPFQGMVRQKPSLGT 1020
Query: 1021 MPVQVTPPRGAFSPGMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQF 1080
MPVQVTPPRGAFSPGMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQF
Sbjct: 1021 MPVQVTPPRGAFSPGMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQF 1080
Query: 1081 AATAPVGINMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQLIQQQRAMLMRQQSF 1140
AATAPVGINMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQLIQQQRAMLMRQQSF
Sbjct: 1081 AATAPVGINMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQLIQQQRAMLMRQQSF 1140
Query: 1141 GNNLPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLAN 1200
GNNLPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLAN
Sbjct: 1141 GNNLPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLAN 1200
Query: 1201 RNSMVSRGMTGNIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPI 1260
RNSMVSRGMTGNIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPI
Sbjct: 1201 RNSMVSRGMTGNIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPI 1260
Query: 1261 PPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVS 1320
PPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVS
Sbjct: 1261 PPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVS 1320
Query: 1321 MAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLKTE 1380
MAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLKTE
Sbjct: 1321 MAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLKTE 1380
Query: 1381 ADGTQVQQVQVFADVQCTVNLVGGDPYLNQPGPLGTQKPTSGPQTPQAQQKSLLQQLLTE 1440
ADGTQVQQVQVFADVQCTVNLVGGDPYLNQPGPLGTQKPTSGPQTPQAQQKSLLQQLLTE
Sbjct: 1381 ADGTQVQQVQVFADVQCTVNLVGGDPYLNQPGPLGTQKPTSGPQTPQAQQKSLLQQLLTE 1440
>gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens]
Length = 1441
Score = 2870 bits (7441), Expect = 0.0
Identities = 1440/1441 (99%), Positives = 1440/1441 (99%), Gaps = 1/1441 (0%)
Query: 1 MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSL 60
MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSL
Sbjct: 1 MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSL 60
Query: 61 SVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEAL 120
SVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEAL
Sbjct: 61 SVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEAL 120
Query: 121 DGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNG 180
DGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNG
Sbjct: 121 DGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNG 180
Query: 181 VPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQ 240
VPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQ
Sbjct: 181 VPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQ 240
Query: 241 SCLICIARRLPRPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFF 300
SCLICIARRLPRPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFF
Sbjct: 241 SCLICIARRLPRPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFF 300
Query: 301 QPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMG 360
QPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMG
Sbjct: 301 QPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMG 360
Query: 361 IHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINR 420
IHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINR
Sbjct: 361 IHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINR 420
Query: 421 QQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTG 480
QQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTG
Sbjct: 421 QQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTG 480
Query: 481 ISLAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTS 540
ISLAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTS
Sbjct: 481 ISLAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTS 540
Query: 541 LQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDN 600
LQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDN
Sbjct: 541 LQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDN 600
Query: 601 SSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSC 660
SSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSC
Sbjct: 601 SSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSC 660
Query: 661 TGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVS 720
TGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVS
Sbjct: 661 TGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVS 720
Query: 721 VTGQVQGNSSIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQ 780
VTGQVQGNSSIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQ
Sbjct: 721 VTGQVQGNSSIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQ 780
Query: 781 MDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQFDQLLPTLEKAAQLPGLCETDRMDGAV 840
MDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQFDQLLPTLEKAAQLPGLCETDRMDGAV
Sbjct: 781 MDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQFDQLLPTLEKAAQLPGLCETDRMDGAV 840
Query: 841 TSVTIKSEILPASLQSATARPTSRLNRLPELELEAIDNQFGQPGTGDQIPWTNNTVTAIN 900
TSVTIKSEILPASLQSATARPTSRLNRLPELELEAIDNQFGQPGTGDQIPWTNNTVTAIN
Sbjct: 841 TSVTIKSEILPASLQSATARPTSRLNRLPELELEAIDNQFGQPGTGDQIPWTNNTVTAIN 900
Query: 901 QSKSEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKL 960
QSKSEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKL
Sbjct: 901 QSKSEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKL 960
Query: 961 VQGGGLDVLSERFPPQQATPPLIMEERPNLYSQPYSSPSPTANLPSPFQGMVRQKPSLGT 1020
VQGGGLDVLSERFPPQQATPPLIMEERPNLYSQPYSSPSPTANLPSPFQGMVRQKPSLGT
Sbjct: 961 VQGGGLDVLSERFPPQQATPPLIMEERPNLYSQPYSSPSPTANLPSPFQGMVRQKPSLGT 1020
Query: 1021 MPVQVTPPRGAFSPGMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQF 1080
MPVQVTPPRGAFSPGMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQF
Sbjct: 1021 MPVQVTPPRGAFSPGMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQF 1080
Query: 1081 AATAPVGINMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQLIQQQRAMLMRQQSF 1140
AATAPVGINMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQLIQQQRAMLMRQQSF
Sbjct: 1081 AATAPVGINMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQLIQQQRAMLMRQQSF 1140
Query: 1141 GNNLPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLAN 1200
GNNLPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLAN
Sbjct: 1141 GNNLPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLAN 1200
Query: 1201 RNSMVSRGMTGNIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPI 1260
RNSMVSRGMTGNIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPI
Sbjct: 1201 RNSMVSRGMTGNIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPI 1260
Query: 1261 PPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVS 1320
PPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVS
Sbjct: 1261 PPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVS 1320
Query: 1321 MAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLKTE 1380
MAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLKTE
Sbjct: 1321 MAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLKTE 1380
Query: 1381 ADGT-QVQQVQVFADVQCTVNLVGGDPYLNQPGPLGTQKPTSGPQTPQAQQKSLLQQLLT 1439
ADGT QVQQVQVFADVQCTVNLVGGDPYLNQPGPLGTQKPTSGPQTPQAQQKSLLQQLLT
Sbjct: 1381 ADGTQQVQQVQVFADVQCTVNLVGGDPYLNQPGPLGTQKPTSGPQTPQAQQKSLLQQLLT 1440
Query: 1440 E 1440
E
Sbjct: 1441 E 1441
>gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens]
Length = 1399
Score = 2768 bits (7176), Expect = 0.0
Identities = 1388/1398 (99%), Positives = 1391/1398 (99%)
Query: 1 MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSL 60
MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSL
Sbjct: 1 MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSL 60
Query: 61 SVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEAL 120
SVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEAL
Sbjct: 61 SVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEAL 120
Query: 121 DGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNG 180
DGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNG
Sbjct: 121 DGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNG 180
Query: 181 VPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQ 240
VPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQ
Sbjct: 181 VPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQ 240
Query: 241 SCLICIARRLPRPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFF 300
SCLICIARRLPRPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFF
Sbjct: 241 SCLICIARRLPRPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFF 300
Query: 301 QPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMG 360
QPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMG
Sbjct: 301 QPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMG 360
Query: 361 IHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINR 420
IHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINR
Sbjct: 361 IHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINR 420
Query: 421 QQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTG 480
QQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTG
Sbjct: 421 QQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTG 480
Query: 481 ISLAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTS 540
ISLAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTS
Sbjct: 481 ISLAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTS 540
Query: 541 LQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDN 600
LQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDN
Sbjct: 541 LQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDN 600
Query: 601 SSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSC 660
SSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSC
Sbjct: 601 SSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSC 660
Query: 661 TGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVS 720
TGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVS
Sbjct: 661 TGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVS 720
Query: 721 VTGQVQGNSSIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQ 780
VTGQVQGNSSIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQ
Sbjct: 721 VTGQVQGNSSIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQ 780
Query: 781 MDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQFDQLLPTLEKAAQLPGLCETDRMDGAV 840
MDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQFDQLLPTLEKAAQLPGLCETDRMDGAV
Sbjct: 781 MDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQFDQLLPTLEKAAQLPGLCETDRMDGAV 840
Query: 841 TSVTIKSEILPASLQSATARPTSRLNRLPELELEAIDNQFGQPGTGDQIPWTNNTVTAIN 900
TSVTIKSEILPASLQSATARPTSRLNRLPELELEAIDNQFGQPGTGDQIPWTNNTVTAIN
Sbjct: 841 TSVTIKSEILPASLQSATARPTSRLNRLPELELEAIDNQFGQPGTGDQIPWTNNTVTAIN 900
Query: 901 QSKSEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKL 960
QSKSEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKL
Sbjct: 901 QSKSEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKL 960
Query: 961 VQGGGLDVLSERFPPQQATPPLIMEERPNLYSQPYSSPSPTANLPSPFQGMVRQKPSLGT 1020
VQGGGLDVLSERFPPQQATPPLIMEERPNLYSQPYSSPSPTANLPSPFQGMVRQKPSLGT
Sbjct: 961 VQGGGLDVLSERFPPQQATPPLIMEERPNLYSQPYSSPSPTANLPSPFQGMVRQKPSLGT 1020
Query: 1021 MPVQVTPPRGAFSPGMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQF 1080
MPVQVTPPRGAFSPGMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQF
Sbjct: 1021 MPVQVTPPRGAFSPGMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQF 1080
Query: 1081 AATAPVGINMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQLIQQQRAMLMRQQSF 1140
AATAPVGINMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQLIQQQRAMLMRQQSF
Sbjct: 1081 AATAPVGINMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQLIQQQRAMLMRQQSF 1140
Query: 1141 GNNLPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLAN 1200
GNNLPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLAN
Sbjct: 1141 GNNLPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLAN 1200
Query: 1201 RNSMVSRGMTGNIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPI 1260
RNSMVSRGMTGNIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPI
Sbjct: 1201 RNSMVSRGMTGNIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPI 1260
Query: 1261 PPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVS 1320
PPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVS
Sbjct: 1261 PPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVS 1320
Query: 1321 MAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLKTE 1380
MAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLKTE
Sbjct: 1321 MAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLKTE 1380
Query: 1381 ADGTQVQQVQVFADVQCT 1398
ADGTQ ++ + F V T
Sbjct: 1381 ADGTQDKKTEEFFSVVTT 1398
>gi|5729858 nuclear receptor coactivator 2 [Homo sapiens]
Length = 1464
Score = 587 bits (1514), Expect = e-167
Identities = 376/891 (42%), Positives = 521/891 (58%), Gaps = 66/891 (7%)
Query: 1 MSGLGDSSSDPANPDSHKRKGSPCDTLASS----TEKRRREQENKYLEELAELLSANISD 56
MSG+G+++SDP+ ++ KRK P D L S TEKR REQENKY+EELAEL+ AN +D
Sbjct: 1 MSGMGENTSDPSRAETRKRKECP-DQLGPSPKRNTEKRNREQENKYIEELAELIFANFND 59
Query: 57 IDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLL 116
ID+ + KPDKC ILK+TV QI+ +K E+ + D+VQKSD+SS+ QGVI+K++LGP++
Sbjct: 60 IDNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMM 119
Query: 117 LEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKS 176
LEALDGFFFVVN EG +VFVSENVT YL YNQEELMN SVYSILHVGDH EFVKNLLPKS
Sbjct: 120 LEALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKS 179
Query: 177 LVNGVPWPQEATRRNSHTFNCRMLIHP-PD--EPGTENQEACQRYEVMQCFTVSQPKSIQ 233
+VNG W E RRNSHTFNCRML+ P PD E G +NQEA Q+YE MQCF VSQPKSI+
Sbjct: 180 IVNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFAVSQPKSIK 239
Query: 234 EDGEDFQSCLICIARRLP--RPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDL 291
E+GED QSCLIC+ARR+P P + ESF T+QD GKI S+DTS++RAA + GWEDL
Sbjct: 240 EEGEDLQSCLICVARRVPMKERPVLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDL 299
Query: 292 VRKCIYAFF-QPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQ 350
VR+CI F Q +G SYA++ EV+ +G A S YRF L+DGT+++A TK KL Q
Sbjct: 300 VRRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQ 359
Query: 351 SPDMQPFIMGIHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSN 410
+ + ++ +H++ RE + D +NP S SPAH S P
Sbjct: 360 TTNEPQLVISLHMLHREQNVCVMNPDLTGQTMGKPLNPI--SSNSPAHQALCSGN--PGQ 415
Query: 411 SNMVSTRINRQQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLN 470
+S+ IN + G FG S G V+ + + Q SN +L
Sbjct: 416 DMTLSSNINFP-----INGPKEQMGMPMGRFGGSGGMNHVSGMQ----ATTPQGSNYALK 466
Query: 471 LNNSPMEGTGISLAQ---FMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACN 527
+N+ G++ Q +SPR +++ G+A PR+P + F P +L SPVG+ SS
Sbjct: 467 MNSPSQSSPGMNPGQPTSMLSPRHRMSPGVAGSPRIPPSQFSP-AGSLHSPVGVCSS--T 523
Query: 528 NNNRSYSNIPVTSLQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQP-AKAESKDNK 586
N+ SY+N + +LQ ++EG S+G S +SP L+ + QNSP +N P +K S D+K
Sbjct: 524 GNSHSYTNSSLNALQALSEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSLDSK 583
Query: 587 EIASILNEMIQSDNSSSDGKPLDSGLLHNND---------RLSDGDSKY--SQTSHKLVQ 635
+ + E + ++ ND +DG S+ S+ KL+Q
Sbjct: 584 DCFGLYGEPSEGTTGQAESSCHPGEQKETNDPNLPPAVSSERADGQSRLHDSKGQTKLLQ 643
Query: 636 LLTTTAEQQLRHADIDTSCKDVLSCTGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQ 695
LLTT ++ Q+ + + +S D +N S S GS + +SL E+HKILHRLLQ
Sbjct: 644 LLTTKSD-QMEPSPLASSLSD-------TNKDSTGSLPGSGSTHGTSLKEKHKILHRLLQ 695
Query: 696 E-GSPSDITTLSVEPDKKDSASTSVSVTGQVQGNSSIKLELDASKKKESKDHQLLRYLLD 754
+ SP D+ L+ E KD + S S +IK E + KKKE + LLRYLLD
Sbjct: 696 DSSSPVDLAKLTAEATGKDLSQESSSTA--PGSEVTIKQEPVSPKKKE---NALLRYLLD 750
Query: 755 KDEKDLRSTPNLSLDDVKVKVEKKE-QMDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQ 813
KD+ T ++ L ++ K+E+ + + DP + K EE+ E Q ++LD
Sbjct: 751 KDD-----TKDIGLPEITPKLERLDSKTDPASNTKLIAMKTEKEEMSFEPGDQPGSELDN 805
Query: 814 FDQLLPTLEKAAQLPGLCETDRMD---GAVTSVTIKSEILPASLQSATARP 861
+++L L+ +QLP L R G+V I ++++ + +++ P
Sbjct: 806 LEEILDDLQN-SQLPQLFPDTRPGAPAGSVDKQAIINDLMQLTAENSPVTP 855
Score = 225 bits (573), Expect = 3e-58
Identities = 285/1082 (26%), Positives = 449/1082 (41%), Gaps = 214/1082 (19%)
Query: 377 TNSGMSIPRVNPSVNP--SISPAHGVARSSTLPP----------SNSNMVSTRINRQQSS 424
+++G S N S+N ++S HGV+ S+L S NM +++ S
Sbjct: 521 SSTGNSHSYTNSSLNALQALSEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSL 580
Query: 425 DLHSSSHSNSSNSQGSFG-----CSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGT 479
D S+G+ G C PG Q N SS+ ++ L++S +
Sbjct: 581 DSKDCFGLYGEPSEGTTGQAESSCHPGEQKETNDPNLPPAVSSERADGQSRLHDSKGQTK 640
Query: 480 GISLAQFMSPRRQ---VTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNR-SYSN 535
+ L S + + + S L+ + S P + ST + + + + S S
Sbjct: 641 LLQLLTTKSDQMEPSPLASSLSDTNKDSTGSLPGSGSTHGTSLKEKHKILHRLLQDSSSP 700
Query: 536 IPVTSLQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEM 595
+ + L G + S S+++P S + +P + K+N ++L +
Sbjct: 701 VDLAKLTAEATGKDLSQESSSTAP--------GSEVTIKQEPVSPKKKEN----ALLRYL 748
Query: 596 IQSDNSSSDGKPLDSGLLHNNDRLSDGDSKYSQTSH-KLVQLLTTTAEQQLRHADIDTSC 654
+ D++ D GL +L DSK S+ KL+ + T E D S
Sbjct: 749 LDKDDTK------DIGLPEITPKLERLDSKTDPASNTKLIAMKTEKEEMSFEPGDQPGSE 802
Query: 655 KDVLS--CTGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKK 712
D L NS + P + + ++ I++ L+Q L+ E
Sbjct: 803 LDNLEEILDDLQNSQLPQLFPDTRPGAPAGSVDKQAIINDLMQ---------LTAE---- 849
Query: 713 DSASTSVSVTGQVQGNSSIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVK 772
+S T V G L + S + QL R L ++ NL LD
Sbjct: 850 NSPVTPV-------GAQKTALRISQSTFNNPRPGQLGRLLPNQ---------NLPLDITL 893
Query: 773 VKVEKKEQMDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQFDQ----------LLPTLE 822
P + P P + + +L +P+ E
Sbjct: 894 QSPTGAGPFPPIRNSSPYSVIPQPGMMGNQGMIGNQGNLGNSSTGMIGNSASRPTMPSGE 953
Query: 823 KAAQLPGLCETDRMDGAVTSVTIKSEILPASLQSATARPTSRLNRLPELELEA------- 875
A Q + T + + ++ ++ S RP+S+ + L+ +
Sbjct: 954 WAPQSSAVRVTCAATTSAMNRPVQGGMIRNPAASIPMRPSSQPGQRQTLQSQVMNIGPSE 1013
Query: 876 IDNQFGQPGTGDQ-------IPWTNNTVTAINQSK---SEDQCISSQLDELLCPPTTVEG 925
++ G P Q PW + + I+Q+ Q S D+LLCP E
Sbjct: 1014 LEMNMGGPQYSQQQAPPNQTAPWPES-ILPIDQASFASQNRQPFGSSPDDLLCPHPAAES 1072
Query: 926 RNDEKALLEQLVSFLSGKDETELAELDRALGIDKLV-QGGGLDVLSERFPPQQATPPLIM 984
+DE ALL+QL +L+ ++ L E+DRALGI +LV Q +D E+F Q + +++
Sbjct: 1073 PSDEGALLDQL--YLALRNFDGLEEIDRALGIPELVSQSQAVD--PEQFSSQDSN--IML 1126
Query: 985 EERPNLYSQPYSSPSPTAN-----LPSPFQGMVRQKPSLGTMPVQVTPPRGAFSPGMGMQ 1039
E++ ++ Q Y+S + A + P + Q+PS T+ +Q P G++
Sbjct: 1127 EQKAPVFPQQYASQAQMAQGSYSPMQDPNFHTMGQRPSYATLRMQPRP---------GLR 1177
Query: 1040 PRQTLNRPPAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQFAATAPVGINMRSGMQQQIT 1099
P + P NQLRLQLQ RLQ QQ NRQ ++NQ + + V + +R G +
Sbjct: 1178 PTGLVQNQP---NQLRLQLQHRLQAQQ-----NRQPLMNQISNVSNVNLTLRPG----VP 1225
Query: 1100 PQPPLNAQMLAQRQRELYSQQHRQRQLIQQQ----RAMLMRQQSFGNNLPPS----SGLP 1151
Q P+NAQMLAQRQRE+ +Q RQRQ+ QQQ R ++MR Q G N+ PS SG+P
Sbjct: 1226 TQAPINAQMLAQRQREILNQHLRQRQMHQQQQVQQRTLMMRGQ--GLNMTPSMVAPSGMP 1283
Query: 1152 VQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLANRNSMVSRGMTG 1211
M NPR+PQ QQFP+PPNYG + P T A P++ L
Sbjct: 1284 ATMSNPRIPQANAQQFPFPPNYGISQQPDPGFTG-----ATTPQSPL------------- 1325
Query: 1212 NIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPIPPPQSSLLQQT 1271
++P+M Q P M+ Q +AN A
Sbjct: 1326 ---------MSPRMAHT--QSP---MMQQSQANPA------------------------- 1346
Query: 1272 PPASGYQSP-DMKAWQQGAIGNNNVFSQAVQNQP---TPAQPGVY-NNMSITVSMAGGNT 1326
YQ+P D+ W QG +G N++FSQ Q+ P A +Y NNM+I VSMA
Sbjct: 1347 -----YQAPSDINGWAQGNMGGNSMFSQ--QSPPHFGQQANTSMYSNNMNINVSMATNTG 1399
Query: 1327 NVQNMNPMMAQMQM---SSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLKTEADG 1383
+ +MN M Q+ M +S+ G++++ PEQ+NDPALR L+ NQL D++K E D
Sbjct: 1400 GMSSMNQMTGQISMTSVTSVPTSGLSSMGPEQVNDPALRGGNLFPNQLPGMDMIKQEGDT 1459
Query: 1384 TQ 1385
T+
Sbjct: 1460 TR 1461
>gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens]
Length = 1424
Score = 494 bits (1273), Expect = e-139
Identities = 340/866 (39%), Positives = 504/866 (58%), Gaps = 104/866 (12%)
Query: 1 MSGLGDSSSDPANPDSHKRKGSPCDT----LASSTEKRRREQENKYLEELAELLSANISD 56
MSGLG++ DP DS KRK PCDT L S EKRRREQE+KY+EELAEL+SAN+SD
Sbjct: 1 MSGLGENL-DPLASDSRKRK-LPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSD 58
Query: 57 IDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS-TTDDDVQKSDISSSSQGVIEKESLGPL 115
ID+ +VKPDKC ILK+TV QI+ +K EQ K+ + DDDVQK+D+SS+ QGVI+K+SLGPL
Sbjct: 59 IDNFNVKPDKCAILKETVRQIRQIK--EQGKTISNDDDVQKADVSSTGQGVIDKDSLGPL 116
Query: 116 LLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPK 175
LL+ALDGF FVVN +G IVFVSENVT YL Y QE+L+NTSVY+ILH D +F+KN LPK
Sbjct: 117 LLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKN-LPK 175
Query: 176 SLVNGVPWPQEATRRNSHTFNCRMLIHPPD---EPGTENQEACQRYEVMQCFTVSQPKSI 232
S VNGV W E R+ SHTFNCRML+ P E + E QRYE MQCF +SQP+++
Sbjct: 176 STVNGVSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAM 235
Query: 233 QEDGEDFQSCLICIARRLPRPPAI--TGVESFMTKQDTTGKIISIDTSSLRAAGRTGWED 290
E+GED QSC+IC+ARR+ + ESF+T+ D +GK+++IDT+SLR++ R G+ED
Sbjct: 236 MEEGEDLQSCMICVARRITTGERTFPSNPESFITRHDLSGKVVNIDTNSLRSSMRPGFED 295
Query: 291 LVRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLC-YP 349
++R+CI FF + ++ +QE G A +P YRF L DGT+++A TK KL P
Sbjct: 296 IIRRCIQRFFSLNDGQSWSQKRHYQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRNP 355
Query: 350 QSPDMQPFIMGIHIIDREHSGLSPQ-DDTNSGMSIPRV--NPSV-NPSISPAHGVARSST 405
+ D F+ H + RE +G P + G+ P N SV S+SP G+
Sbjct: 356 VTNDRHGFV-STHFLQREQNGYRPNPNPVGQGIRPPMAGCNSSVGGMSMSPNQGL----Q 410
Query: 406 LPPSNSNMVSTRINRQQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSS 465
+P S + ++ Q S SN ++ +PG + Q +S Q++
Sbjct: 411 MPSSRAYGLADPSTTGQMSGARYGGSSNIAS------LTPGPGM-------QSPSSYQNN 457
Query: 466 NPSLNLNNSPMEGTGISLAQ---FMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMT 522
N LN+++ P G++ Q +SPR + + P++ ++ F P ++ + SP+
Sbjct: 458 NYGLNMSSPPHGSPGLAPNQQNIMISPRNRGS------PKIASHQFSP-VAGVHSPM--- 507
Query: 523 SSACNNNNRSYSNIPVTSLQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAES 582
+S+ N N S+S+ +++LQ ++EG S+ + SSP NSP+ QP+K +
Sbjct: 508 ASSGNTGNHSFSSSSLSALQAISEGVGTSLLSTLSSP---GPKLDNSPNMNITQPSKVSN 564
Query: 583 KDNKEIASILNEMIQSDNSSSDGKPLDSGLLHNN--DRLSDGDSKYSQTS---------- 630
+D+K D P++S + +N D LSD +SK S
Sbjct: 565 QDSKSPLGFY----------CDQNPVESSMCQSNSRDHLSDKESKESSVEGAENQRGPLE 614
Query: 631 ----HKLVQLLTTTAEQQ----LRHADIDTSCKDVLSCTGTSNSASANSSGGSCPSSH-- 680
KL+QLLT +++ + L ++ +D+SCK+ + + S+++SGG +S+
Sbjct: 615 SKGHKKLLQLLTCSSDDRGHSSLTNSPLDSSCKESSVSVTSPSGVSSSTSGGVSSTSNMH 674
Query: 681 -SSLTERHKILHRLLQEG-SPSDITTLSVEPDKKDSASTSVSVTGQVQGNSSIKLELDAS 738
S L E+H+ILH+LLQ G SP+++ ++ E KD++S + G V +K E +
Sbjct: 675 GSLLQEKHRILHKLLQNGNSPAEVAKITAEATGKDTSSITSCGDGNV-----VKQEQLSP 729
Query: 739 KKKESKDHQLLRYLLDKDEKDLRSTPNLSLD-DVKVKVEKKE-QMDPCNTNPTPMTKPTP 796
KKKE ++ LLRYLLD+D+ P+ +L +++ +VE + +M C ++ P +
Sbjct: 730 KKKE--NNALLRYLLDRDD------PSDALSKELQPQVEGVDNKMSQCTSSTIPSSSQEK 781
Query: 797 E-EIKLEAQSQFTADLDQFDQLLPTL 821
+ +IK E + + DLD D +L L
Sbjct: 782 DPKIKTETSEEGSGDLDNLDAILGDL 807
Score = 201 bits (512), Expect = 3e-51
Identities = 274/1102 (24%), Positives = 442/1102 (40%), Gaps = 254/1102 (23%)
Query: 369 SGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINRQQS----- 423
+ L+P S S N +N S SP HG S L P+ N++ + NR
Sbjct: 440 ASLTPGPGMQSPSSYQNNNYGLNMS-SPPHG---SPGLAPNQQNIMISPRNRGSPKIASH 495
Query: 424 -----SDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASS---QSSNPSLNLNNSP 475
+ +HS S+ + SF S + A A+++G +S S+P L+NSP
Sbjct: 496 QFSPVAGVHSPMASSGNTGNHSFS---SSSLSALQAISEGVGTSLLSTLSSPGPKLDNSP 552
Query: 476 ----MEGTGISLAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSA------ 525
+ + +S SP M ++ ++S S A
Sbjct: 553 NMNITQPSKVSNQDSKSPLGFYCDQNPVESSMCQSNSRDHLSDKESKESSVEGAENQRGP 612
Query: 526 --------------CNNNNRSYSN--------------IPVTSLQGMNEGPNNSVGFSAS 557
C++++R +S+ + VTS G++ + V +++
Sbjct: 613 LESKGHKKLLQLLTCSSDDRGHSSLTNSPLDSSCKESSVSVTSPSGVSSSTSGGVSSTSN 672
Query: 558 --SPVLRQ--------MSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDNSSSDGKP 607
+L++ + + NSP+ + A+A KD I S + + S K
Sbjct: 673 MHGSLLQEKHRILHKLLQNGNSPAEVAKITAEATGKDTSSITSCGDGNVVKQEQLSPKKK 732
Query: 608 LDSGLLH---NNDRLSDG------------DSKYSQTSHKLV---------QLLTTTAEQ 643
++ LL + D SD D+K SQ + + ++ T T+E+
Sbjct: 733 ENNALLRYLLDRDDPSDALSKELQPQVEGVDNKMSQCTSSTIPSSSQEKDPKIKTETSEE 792
Query: 644 QLRHAD-IDTSCKDVLSCTGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDI 702
D +D D+ S +NS S+N S L + ++ G S
Sbjct: 793 GSGDLDNLDAILGDLTSSDFYNNSISSNGS---------HLGTKQQVFQGTNSLGLKSSQ 843
Query: 703 TTLSVEPDKKDSAS----TSVSVTGQVQGNSSI----KLELDASKKKESKDHQLLRYLLD 754
+ S+ P + S SV + V+ S+ K + + + +
Sbjct: 844 SVQSIRPPYNRAVSLDSPVSVGSSPPVKNISAFPMLPKQPMLGGNPRMMDSQENYGSSMG 903
Query: 755 KDEKDLRSTPNLSLDDVKVKVEKKEQMDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQF 814
+++ T S D + K +M+P N+N M +P + +
Sbjct: 904 GPNRNVTVTQTPSSGDWGLPNSKAGRMEPMNSNS--MGRPGGD----------------Y 945
Query: 815 DQLLPTLEKAAQLPGLCETDRMDGAVTSVTIKSEILPASLQSATARPTSRLNRLPELELE 874
+ LP + G++ ++ ++S +P + + R E+ +
Sbjct: 946 NTSLPR-------------PALGGSIPTLPLRSNSIPGARPVLQQQQQMLQMRPGEIPMG 992
Query: 875 AIDNQFGQPGTGDQI-PWTNNTVTA--INQSKSEDQCISSQLDELLCPPTTVEGRNDEKA 931
N +GQ +Q+ W + ++ ++ + + LD+L+ PP+ +EG++DE+A
Sbjct: 993 MGANPYGQAAASNQLGSWPDGMLSMEQVSHGTQNRPLLRNSLDDLVGPPSNLEGQSDERA 1052
Query: 932 LLEQLVSFLSGKDETELAELDRALGIDKLV-QGGGLDVLSERFPPQQATPPLIMEERPNL 990
LL+QL + LS D T L E+DRALGI +LV QG L+ + F Q+A ++M+++ L
Sbjct: 1053 LLDQLHTLLSNTDATGLEEIDRALGIPELVNQGQALEPKQDAFQGQEAA--VMMDQKAGL 1110
Query: 991 YSQPYSSPSPTANLPSPFQG---MVRQKPSLGTMPVQVTPPRGAFSPGMGMQPRQTLNRP 1047
Y Q Y + P P QG + Q PS +M Q+ +G F P GM PR + RP
Sbjct: 1111 YGQTYPAQGP------PMQGGFHLQGQSPSFNSMMNQMN-QQGNF-PLQGMHPRANIMRP 1162
Query: 1048 PA-APNQLRLQLQQRLQGQQQLIHQNRQAI-LNQFAATAPVGINMRSGMQQQITPQPP-L 1104
P QLR+QLQQRLQG QQ ++Q+RQA+ L TA MR MQ Q++ Q L
Sbjct: 1163 RTNTPKQLRMQLQQRLQG-QQFLNQSRQALELKMENPTAGGAAVMRPMMQPQVSSQQGFL 1221
Query: 1105 NAQMLAQRQRELYS---------------------QQHRQRQLIQQQRAMLMRQQSFGNN 1143
NAQM+AQR REL S QQ +Q+Q QQQ+ +QQ+ +
Sbjct: 1222 NAQMVAQRSRELLSHHFRQQRVAMMMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTQAFS 1281
Query: 1144 LPP----SSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLA 1199
PP S + + P +PQ PQQFPY PNYG PA F ++++ P A ++
Sbjct: 1282 PPPNVTASPSMDGLLAGPTMPQAPPQQFPYQPNYGMGQQPDPA----FGRVSSPPNAMMS 1337
Query: 1200 NRNSMVSRGMTGNIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMP 1259
+R G NP MQ
Sbjct: 1338 SR---------------MGPSQNPMMQH-------------------------------- 1350
Query: 1260 IPPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITV 1319
PQ+ AS YQS +MK W G + N+ FSQ Q P VY+ + +
Sbjct: 1351 ---PQA--------ASIYQSSEMKGWPSGNLARNSSFSQ--QQFAHQGNPAVYS--MVHM 1395
Query: 1320 SMAGGNTNVQNMNPM-MAQMQM 1340
+ + G+ NMNPM M+ M M
Sbjct: 1396 NGSSGHMGQMNMNPMPMSGMPM 1417
>gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens]
Length = 1420
Score = 494 bits (1273), Expect = e-139
Identities = 340/866 (39%), Positives = 504/866 (58%), Gaps = 104/866 (12%)
Query: 1 MSGLGDSSSDPANPDSHKRKGSPCDT----LASSTEKRRREQENKYLEELAELLSANISD 56
MSGLG++ DP DS KRK PCDT L S EKRRREQE+KY+EELAEL+SAN+SD
Sbjct: 1 MSGLGENL-DPLASDSRKRK-LPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSD 58
Query: 57 IDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS-TTDDDVQKSDISSSSQGVIEKESLGPL 115
ID+ +VKPDKC ILK+TV QI+ +K EQ K+ + DDDVQK+D+SS+ QGVI+K+SLGPL
Sbjct: 59 IDNFNVKPDKCAILKETVRQIRQIK--EQGKTISNDDDVQKADVSSTGQGVIDKDSLGPL 116
Query: 116 LLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPK 175
LL+ALDGF FVVN +G IVFVSENVT YL Y QE+L+NTSVY+ILH D +F+KN LPK
Sbjct: 117 LLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKN-LPK 175
Query: 176 SLVNGVPWPQEATRRNSHTFNCRMLIHPPD---EPGTENQEACQRYEVMQCFTVSQPKSI 232
S VNGV W E R+ SHTFNCRML+ P E + E QRYE MQCF +SQP+++
Sbjct: 176 STVNGVSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAM 235
Query: 233 QEDGEDFQSCLICIARRLPRPPAI--TGVESFMTKQDTTGKIISIDTSSLRAAGRTGWED 290
E+GED QSC+IC+ARR+ + ESF+T+ D +GK+++IDT+SLR++ R G+ED
Sbjct: 236 MEEGEDLQSCMICVARRITTGERTFPSNPESFITRHDLSGKVVNIDTNSLRSSMRPGFED 295
Query: 291 LVRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLC-YP 349
++R+CI FF + ++ +QE G A +P YRF L DGT+++A TK KL P
Sbjct: 296 IIRRCIQRFFSLNDGQSWSQKRHYQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRNP 355
Query: 350 QSPDMQPFIMGIHIIDREHSGLSPQ-DDTNSGMSIPRV--NPSV-NPSISPAHGVARSST 405
+ D F+ H + RE +G P + G+ P N SV S+SP G+
Sbjct: 356 VTNDRHGFV-STHFLQREQNGYRPNPNPVGQGIRPPMAGCNSSVGGMSMSPNQGL----Q 410
Query: 406 LPPSNSNMVSTRINRQQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSS 465
+P S + ++ Q S SN ++ +PG + Q +S Q++
Sbjct: 411 MPSSRAYGLADPSTTGQMSGARYGGSSNIAS------LTPGPGM-------QSPSSYQNN 457
Query: 466 NPSLNLNNSPMEGTGISLAQ---FMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMT 522
N LN+++ P G++ Q +SPR + + P++ ++ F P ++ + SP+
Sbjct: 458 NYGLNMSSPPHGSPGLAPNQQNIMISPRNRGS------PKIASHQFSP-VAGVHSPM--- 507
Query: 523 SSACNNNNRSYSNIPVTSLQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAES 582
+S+ N N S+S+ +++LQ ++EG S+ + SSP NSP+ QP+K +
Sbjct: 508 ASSGNTGNHSFSSSSLSALQAISEGVGTSLLSTLSSP---GPKLDNSPNMNITQPSKVSN 564
Query: 583 KDNKEIASILNEMIQSDNSSSDGKPLDSGLLHNN--DRLSDGDSKYSQTS---------- 630
+D+K D P++S + +N D LSD +SK S
Sbjct: 565 QDSKSPLGFY----------CDQNPVESSMCQSNSRDHLSDKESKESSVEGAENQRGPLE 614
Query: 631 ----HKLVQLLTTTAEQQ----LRHADIDTSCKDVLSCTGTSNSASANSSGGSCPSSH-- 680
KL+QLLT +++ + L ++ +D+SCK+ + + S+++SGG +S+
Sbjct: 615 SKGHKKLLQLLTCSSDDRGHSSLTNSPLDSSCKESSVSVTSPSGVSSSTSGGVSSTSNMH 674
Query: 681 -SSLTERHKILHRLLQEG-SPSDITTLSVEPDKKDSASTSVSVTGQVQGNSSIKLELDAS 738
S L E+H+ILH+LLQ G SP+++ ++ E KD++S + G V +K E +
Sbjct: 675 GSLLQEKHRILHKLLQNGNSPAEVAKITAEATGKDTSSITSCGDGNV-----VKQEQLSP 729
Query: 739 KKKESKDHQLLRYLLDKDEKDLRSTPNLSLD-DVKVKVEKKE-QMDPCNTNPTPMTKPTP 796
KKKE ++ LLRYLLD+D+ P+ +L +++ +VE + +M C ++ P +
Sbjct: 730 KKKE--NNALLRYLLDRDD------PSDALSKELQPQVEGVDNKMSQCTSSTIPSSSQEK 781
Query: 797 E-EIKLEAQSQFTADLDQFDQLLPTL 821
+ +IK E + + DLD D +L L
Sbjct: 782 DPKIKTETSEEGSGDLDNLDAILGDL 807
Score = 198 bits (504), Expect = 3e-50
Identities = 274/1101 (24%), Positives = 440/1101 (39%), Gaps = 256/1101 (23%)
Query: 369 SGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINRQQS----- 423
+ L+P S S N +N S SP HG S L P+ N++ + NR
Sbjct: 440 ASLTPGPGMQSPSSYQNNNYGLNMS-SPPHG---SPGLAPNQQNIMISPRNRGSPKIASH 495
Query: 424 -----SDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASS---QSSNPSLNLNNSP 475
+ +HS S+ + SF S + A A+++G +S S+P L+NSP
Sbjct: 496 QFSPVAGVHSPMASSGNTGNHSFS---SSSLSALQAISEGVGTSLLSTLSSPGPKLDNSP 552
Query: 476 ----MEGTGISLAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSA------ 525
+ + +S SP M ++ ++S S A
Sbjct: 553 NMNITQPSKVSNQDSKSPLGFYCDQNPVESSMCQSNSRDHLSDKESKESSVEGAENQRGP 612
Query: 526 --------------CNNNNRSYSN--------------IPVTSLQGMNEGPNNSVGFSAS 557
C++++R +S+ + VTS G++ + V +++
Sbjct: 613 LESKGHKKLLQLLTCSSDDRGHSSLTNSPLDSSCKESSVSVTSPSGVSSSTSGGVSSTSN 672
Query: 558 --SPVLRQ--------MSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDNSSSDGKP 607
+L++ + + NSP+ + A+A KD I S + + S K
Sbjct: 673 MHGSLLQEKHRILHKLLQNGNSPAEVAKITAEATGKDTSSITSCGDGNVVKQEQLSPKKK 732
Query: 608 LDSGLLH---NNDRLSDG------------DSKYSQTSHKLV---------QLLTTTAEQ 643
++ LL + D SD D+K SQ + + ++ T T+E+
Sbjct: 733 ENNALLRYLLDRDDPSDALSKELQPQVEGVDNKMSQCTSSTIPSSSQEKDPKIKTETSEE 792
Query: 644 QLRHAD-IDTSCKDVLSCTGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDI 702
D +D D+ S +NS S+N S L + ++ G S
Sbjct: 793 GSGDLDNLDAILGDLTSSDFYNNSISSNGS---------HLGTKQQVFQGTNSLGLKSSQ 843
Query: 703 TTLSVEPDKKDSAS----TSVSVTGQVQGNSSI----KLELDASKKKESKDHQLLRYLLD 754
+ S+ P + S SV + V+ S+ K + + + +
Sbjct: 844 SVQSIRPPYNRAVSLDSPVSVGSSPPVKNISAFPMLPKQPMLGGNPRMMDSQENYGSSMG 903
Query: 755 KDEKDLRSTPNLSLDDVKVKVEKKEQMDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQF 814
+++ T S D + K +M+P N+N M +P + +
Sbjct: 904 GPNRNVTVTQTPSSGDWGLPNSKAGRMEPMNSNS--MGRPGGD----------------Y 945
Query: 815 DQLLPTLEKAAQLPGLCETDRMDGAVTSVTIKSEILPASLQSATARPTSRLNRLPELELE 874
+ LP + G++ ++ ++S +P + + R E+ +
Sbjct: 946 NTSLPR-------------PALGGSIPTLPLRSNSIPGARPVLQQQQQMLQMRPGEIPMG 992
Query: 875 AIDNQFGQPGTGDQI-PWTNNTVTA--INQSKSEDQCISSQLDELLCPPTTVEGRNDEKA 931
N +GQ +Q+ W + ++ ++ + + LD+L+ PP+ +EG++DE+A
Sbjct: 993 MGANPYGQAAASNQLGSWPDGMLSMEQVSHGTQNRPLLRNSLDDLVGPPSNLEGQSDERA 1052
Query: 932 LLEQLVSFLSGKDETELAELDRALGIDKLV-QGGGLDVLSERFPPQQATPPLIMEERPNL 990
LL+QL + LS D T L E+DRALGI +LV QG L+ + F Q+A ++M+++ L
Sbjct: 1053 LLDQLHTLLSNTDATGLEEIDRALGIPELVNQGQALEPKQDAFQGQEAA--VMMDQKAGL 1110
Query: 991 YSQPYSSPSPTANLPSPFQG---MVRQKPSLGTMPVQVTPPRGAFSPGMGMQPRQTLNRP 1047
Y Q Y + P P QG + Q PS +M Q+ +G F P GM PR + RP
Sbjct: 1111 YGQTYPAQGP------PMQGGFHLQGQSPSFNSMMNQMN-QQGNF-PLQGMHPRANIMRP 1162
Query: 1048 PA-APNQLRLQLQQRLQGQQQLIHQNRQAI-LNQFAATAPVGINMRSGMQQQITPQPPLN 1105
P QLR+QLQQRLQG QQ ++Q+RQA+ L TA MR MQ Q Q LN
Sbjct: 1163 RTNTPKQLRMQLQQRLQG-QQFLNQSRQALELKMENPTAGGAAVMRPMMQPQ---QGFLN 1218
Query: 1106 AQMLAQRQRELYS---------------------QQHRQRQLIQQQRAMLMRQQSFGNNL 1144
AQM+AQR REL S QQ +Q+Q QQQ+ +QQ+ +
Sbjct: 1219 AQMVAQRSRELLSHHFRQQRVAMMMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTQAFSP 1278
Query: 1145 PP----SSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLAN 1200
PP S + + P +PQ PQQFPY PNYG PA F ++++ P A +++
Sbjct: 1279 PPNVTASPSMDGLLAGPTMPQAPPQQFPYQPNYGMGQQPDPA----FGRVSSPPNAMMSS 1334
Query: 1201 RNSMVSRGMTGNIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPI 1260
R G NP MQ
Sbjct: 1335 R---------------MGPSQNPMMQH--------------------------------- 1346
Query: 1261 PPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVS 1320
PQ+ AS YQS +MK W G + N+ FSQ Q P VY+ + ++
Sbjct: 1347 --PQA--------ASIYQSSEMKGWPSGNLARNSSFSQ--QQFAHQGNPAVYS--MVHMN 1392
Query: 1321 MAGGNTNVQNMNPM-MAQMQM 1340
+ G+ NMNPM M+ M M
Sbjct: 1393 GSSGHMGQMNMNPMPMSGMPM 1413
>gi|21614542 single-minded homolog 1 [Homo sapiens]
Length = 766
Score = 92.0 bits (227), Expect = 4e-18
Identities = 102/425 (24%), Positives = 183/425 (43%), Gaps = 59/425 (13%)
Query: 28 ASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEK 87
+ + + RRE+EN ELA+LL +++ + DK I++ T +++ +
Sbjct: 5 SKNAARTRREKENSEFYELAKLLPLP----SAITSQLDKASIIRLTTSYLKM-------R 53
Query: 88 STTDDDVQKSDISSSSQGVIEK--ESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLG 145
+ + ++ SS ++ LG LL+ LDGF FVV +G+I+++SE + +LG
Sbjct: 54 VVFPEGLGEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLG 113
Query: 146 YNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPD 205
+Q EL S+Y +H DH E L + + QE S + ++ +
Sbjct: 114 LSQVELTGNSIYEYIHPADHDEMTAVLTAHQPYHS-HFVQEYEIERSFFLRMKCVLAKRN 172
Query: 206 EPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQSC-----LICIARRLPRPPAITGVE 260
T C Y+V+ C + + D F C L+ + LP P A+T ++
Sbjct: 173 AGLT-----CGGYKVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLP-PSAVTEIK 226
Query: 261 ----SFMTKQDTTGKIISIDTSSLRAAGRTGWE--DLVRKCIYAFFQPQGREPSYARQLF 314
FM + K+I +D+ R A TG+E DL+ K +Y G + + R
Sbjct: 227 LHSNMFMFRASLDMKLIFLDS---RVAELTGYEPQDLIEKTLY--HHVHGCDTFHLRCAH 281
Query: 315 QEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMGIHII--DREHSGLS 372
++ +G ++ YRF+ G + + + + I+ ++ + D E+ GL
Sbjct: 282 HLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQ 341
Query: 373 PQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINRQQSSDLHSSSHS 432
+S+ +++ S PA SST P+ ++ NR+ + SSS S
Sbjct: 342 --------LSLDQISAS-----KPAFSYTSSST--PTMTD------NRKGAKSRLSSSKS 380
Query: 433 NSSNS 437
S S
Sbjct: 381 KSRTS 385
>gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Homo
sapiens]
Length = 717
Score = 86.7 bits (213), Expect = 2e-16
Identities = 155/650 (23%), Positives = 250/650 (38%), Gaps = 125/650 (19%)
Query: 2 SGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLS 61
SG+ D P R+ S E+RRR + +Y+ EL+++ + +L+
Sbjct: 48 SGMDFDDEDGEGPSKFSRENH------SEIERRRRNKMTQYITELSDM----VPTCSALA 97
Query: 62 VKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEALD 121
KPDK IL+ V MK M + + D K + ++ L L+LEA D
Sbjct: 98 RKPDKLTILRMAVSH---MKSMRGTGNKSTDGAYKPSF-------LTEQELKHLILEAAD 147
Query: 122 GFFFVVNCE-GRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPK----- 175
GF FVV E GR+++VS++VT L Q E +++Y +H D + + L
Sbjct: 148 GFLFVVAAETGRVIYVSDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMT 207
Query: 176 ----SLVNGV--PWPQEATRR----NSHTFNCRM------LIHPPDEPGTEN-------- 211
L G Q+++ R + +F CRM L H P T
Sbjct: 208 GRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGL 267
Query: 212 ---QEACQRYEVMQC---------FTVSQPKSIQEDGEDFQSCLICIAR-RLPRPPAITG 258
+E +Y V+ C ++ P+ + G+ + CL+ I R ++ P
Sbjct: 268 GPVKEGEAQYAVVHCTGYIKAWPPAGMTIPEEDADVGQGSKYCLVAIGRLQVTSSPVCMD 327
Query: 259 VE------SFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQ 312
+ F+++ ++ G I +D + G +DL+ K I F P+ + S+ R+
Sbjct: 328 MNGMSVPTEFLSRHNSDGIITFVDPRCISVIGYQP-QDLLGKDILEFCHPE--DQSHLRE 384
Query: 313 LFQEVM-TRGTASSPSYRF-ILNDGTMLSAHTKCKLCYPQSPDMQPFI-----------M 359
FQ+V+ +G S YRF N ML + P S +++ I
Sbjct: 385 SFQQVVKLKGQVLSVMYRFRTKNREWMLIRTSSFTFQNPYSDEIEYIICTNTNVKQLQQQ 444
Query: 360 GIHIIDREHSGLSPQDDTNSGMSIPRVNPSVN---PSISPAHGVARSSTLPPSNSNMVST 416
+ + GLS D S + +P + V+ S+ A + P
Sbjct: 445 QAELEVHQRDGLSSYD--LSQVPVPNLPAGVHEAGKSVEKADAIFSQERDPRFAEMFAGI 502
Query: 417 RINRQQSSDLHSSSHSNSSNSQGS------FGCSPGSQIVANVALNQGQASSQS----SN 466
+ ++ S++ + SQGS G + S +V +N Q+SS + S
Sbjct: 503 SASEKKMMSSASAAGTQQIYSQGSPFPSGHSGKAFSSSVVHVPGVNDIQSSSSTGQNMSQ 562
Query: 467 PSLNLNNSPMEGTGISLAQFMSPRRQVTSGLATRPRMPNNSFPPNIS-TLSSPVGM-TSS 524
S LN S + TG +RP P P S T SSP G+ TS
Sbjct: 563 ISRQLNQSQVAWTG------------------SRPPFPGQQIPSQSSKTQSSPFGIGTSH 604
Query: 525 ACNNNNRSYSNI--PVTSLQGMN---EGPNNSVGFSASSPVLRQMSSQNS 569
+ SYS + P TS N N + GF+ S Q + S
Sbjct: 605 TYPADPSSYSPLSSPATSSPSGNAYSSLANRTPGFAESGQSSGQFQGRPS 654
>gi|4758010 clock [Homo sapiens]
Length = 846
Score = 84.3 bits (207), Expect = 7e-16
Identities = 56/185 (30%), Positives = 96/185 (51%), Gaps = 19/185 (10%)
Query: 29 SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS 88
+ +EK+RR+Q N ++EL +L N K DK +L+K++D ++ K + +
Sbjct: 40 NKSEKKRRDQFNVLIKELGSMLPGNAR-------KMDKSTVLQKSIDFLRKHKEITAQSD 92
Query: 89 TTD--DDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGY 146
++ D + + +S+ E L+LEALDGFF + +G I++VSE+VTS L +
Sbjct: 93 ASEIRQDWKPTFLSN--------EEFTQLMLEALDGFFLAIMTDGSIIYVSESVTSLLEH 144
Query: 147 NQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRML--IHPP 204
+L++ S+++ + G+H+E K L L + P+ +N F C ML P
Sbjct: 145 LPSDLVDQSIFNFIPEGEHSEVYKILSTHLLESDSLTPEYLKSKNQLEFCCHMLRGTIDP 204
Query: 205 DEPGT 209
EP T
Sbjct: 205 KEPST 209
>gi|4827004 single-minded homolog 2 long isoform [Homo sapiens]
Length = 667
Score = 83.2 bits (204), Expect = 2e-15
Identities = 82/319 (25%), Positives = 142/319 (44%), Gaps = 32/319 (10%)
Query: 28 ASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEK 87
+ + K RRE+EN ELA+LL +++ + DK I++ T +++ +
Sbjct: 5 SKNAAKTRREKENGEFYELAKLLPLP----SAITSQLDKASIIRLTTSYLKMRAVFPEGL 60
Query: 88 STTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYN 147
D + + GV ++ LG LL+ LDGF FVV +G+I+++SE + +LG +
Sbjct: 61 G---DAWGQPSRAGPLDGVAKE--LGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLS 115
Query: 148 QEELMNTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPDEP 207
Q EL S+Y +H DH E L ++ QE S + ++ +
Sbjct: 116 QVELTGNSIYEYIHPSDHDEMTAVLTAHQPLHH-HLLQEYEIERSFFLRMKCVLAKRNAG 174
Query: 208 GTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQSC-----LICIARRLPRPPAITGVE-- 260
T C Y+V+ C + + D + SC L+ + + LP P AIT ++
Sbjct: 175 LT-----CSGYKVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLP-PSAITEIKLY 228
Query: 261 --SFMTKQDTTGKIISIDTSSLRAAGRTGWE--DLVRKCIYAFFQPQGREPSYARQLFQE 316
FM + K+I +D+ R TG+E DL+ K +Y G + + R
Sbjct: 229 SNMFMFRASLDLKLIFLDS---RVTEVTGYEPQDLIEKTLY--HHVHGCDVFHLRYAHHL 283
Query: 317 VMTRGTASSPSYRFILNDG 335
++ +G ++ YR + G
Sbjct: 284 LLVKGQVTTKYYRLLSKRG 302
>gi|194239684 single-minded homolog 2 short isoform [Homo sapiens]
Length = 570
Score = 83.2 bits (204), Expect = 2e-15
Identities = 82/319 (25%), Positives = 142/319 (44%), Gaps = 32/319 (10%)
Query: 28 ASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEK 87
+ + K RRE+EN ELA+LL +++ + DK I++ T +++ +
Sbjct: 5 SKNAAKTRREKENGEFYELAKLLPLP----SAITSQLDKASIIRLTTSYLKMRAVFPEGL 60
Query: 88 STTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYN 147
D + + GV ++ LG LL+ LDGF FVV +G+I+++SE + +LG +
Sbjct: 61 G---DAWGQPSRAGPLDGVAKE--LGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLS 115
Query: 148 QEELMNTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPDEP 207
Q EL S+Y +H DH E L ++ QE S + ++ +
Sbjct: 116 QVELTGNSIYEYIHPSDHDEMTAVLTAHQPLHH-HLLQEYEIERSFFLRMKCVLAKRNAG 174
Query: 208 GTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQSC-----LICIARRLPRPPAITGVE-- 260
T C Y+V+ C + + D + SC L+ + + LP P AIT ++
Sbjct: 175 LT-----CSGYKVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLP-PSAITEIKLY 228
Query: 261 --SFMTKQDTTGKIISIDTSSLRAAGRTGWE--DLVRKCIYAFFQPQGREPSYARQLFQE 316
FM + K+I +D+ R TG+E DL+ K +Y G + + R
Sbjct: 229 SNMFMFRASLDLKLIFLDS---RVTEVTGYEPQDLIEKTLY--HHVHGCDVFHLRYAHHL 283
Query: 317 VMTRGTASSPSYRFILNDG 335
++ +G ++ YR + G
Sbjct: 284 LLVKGQVTTKYYRLLSKRG 302
>gi|71852582 aryl hydrocarbon receptor nuclear translocator-like
isoform b [Homo sapiens]
Length = 582
Score = 81.3 bits (199), Expect = 6e-15
Identities = 88/360 (24%), Positives = 148/360 (41%), Gaps = 64/360 (17%)
Query: 29 SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS 88
S EKRRR++ N +++ELA L+ C + + +D++ +++ Q
Sbjct: 35 SQIEKRRRDKMNSFIDELASLVPT--------------CNAMSRKLDKLTVLRMAVQHMK 80
Query: 89 TTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCE-GRIVFVSENVTSYLGYN 147
T ++ + + L L+L A DGF FVV C+ G+I+FVSE+V L Y+
Sbjct: 81 TLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYS 140
Query: 148 QEELMNTSVYSILHVGDHAEFVKNLLPKS-------LVNG----------VPWPQEATRR 190
Q +L+ S++ LH D A+ VK L S L++ P P
Sbjct: 141 QNDLIGQSLFDYLHPKDIAK-VKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSG 199
Query: 191 NSHTFNCRMLIHPP-------DEPGT-----ENQEACQRYEVMQCFTVSQPK-SIQEDGE 237
+F CRM + P D P T + + C + + K + ED E
Sbjct: 200 ARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNE 259
Query: 238 DFQ-----SCLICIARR----LPRPP----AITGVESFMTKQDTTGKIISIDTSSLRAAG 284
SCL+ I R +P+P + +E ++++ GK + +D +
Sbjct: 260 PDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSME-YVSRHAIDGKFVFVDQRATAILA 318
Query: 285 RTGWEDLVRKCIYAFFQPQ-GREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTK 343
E L C F Q G RQ+ Q TR ++ Y+F + DG+ ++ ++
Sbjct: 319 YLPQELLGTSCYEYFHQDDIGHLAECHRQVLQ---TREKITTNCYKFKIKDGSFITLRSR 375
>gi|71852580 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 81.3 bits (199), Expect = 6e-15
Identities = 88/360 (24%), Positives = 148/360 (41%), Gaps = 64/360 (17%)
Query: 29 SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS 88
S EKRRR++ N +++ELA L+ C + + +D++ +++ Q
Sbjct: 78 SQIEKRRRDKMNSFIDELASLVPT--------------CNAMSRKLDKLTVLRMAVQHMK 123
Query: 89 TTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCE-GRIVFVSENVTSYLGYN 147
T ++ + + L L+L A DGF FVV C+ G+I+FVSE+V L Y+
Sbjct: 124 TLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYS 183
Query: 148 QEELMNTSVYSILHVGDHAEFVKNLLPKS-------LVNG----------VPWPQEATRR 190
Q +L+ S++ LH D A+ VK L S L++ P P
Sbjct: 184 QNDLIGQSLFDYLHPKDIAK-VKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSG 242
Query: 191 NSHTFNCRMLIHPP-------DEPGT-----ENQEACQRYEVMQCFTVSQPK-SIQEDGE 237
+F CRM + P D P T + + C + + K + ED E
Sbjct: 243 ARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNE 302
Query: 238 DFQ-----SCLICIARR----LPRPP----AITGVESFMTKQDTTGKIISIDTSSLRAAG 284
SCL+ I R +P+P + +E ++++ GK + +D +
Sbjct: 303 PDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSME-YVSRHAIDGKFVFVDQRATAILA 361
Query: 285 RTGWEDLVRKCIYAFFQPQ-GREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTK 343
E L C F Q G RQ+ Q TR ++ Y+F + DG+ ++ ++
Sbjct: 362 YLPQELLGTSCYEYFHQDDIGHLAECHRQVLQ---TREKITTNCYKFKIKDGSFITLRSR 418
>gi|42716311 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 81.3 bits (199), Expect = 6e-15
Identities = 88/360 (24%), Positives = 148/360 (41%), Gaps = 64/360 (17%)
Query: 29 SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS 88
S EKRRR++ N +++ELA L+ C + + +D++ +++ Q
Sbjct: 78 SQIEKRRRDKMNSFIDELASLVPT--------------CNAMSRKLDKLTVLRMAVQHMK 123
Query: 89 TTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCE-GRIVFVSENVTSYLGYN 147
T ++ + + L L+L A DGF FVV C+ G+I+FVSE+V L Y+
Sbjct: 124 TLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYS 183
Query: 148 QEELMNTSVYSILHVGDHAEFVKNLLPKS-------LVNG----------VPWPQEATRR 190
Q +L+ S++ LH D A+ VK L S L++ P P
Sbjct: 184 QNDLIGQSLFDYLHPKDIAK-VKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSG 242
Query: 191 NSHTFNCRMLIHPP-------DEPGT-----ENQEACQRYEVMQCFTVSQPK-SIQEDGE 237
+F CRM + P D P T + + C + + K + ED E
Sbjct: 243 ARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNE 302
Query: 238 DFQ-----SCLICIARR----LPRPP----AITGVESFMTKQDTTGKIISIDTSSLRAAG 284
SCL+ I R +P+P + +E ++++ GK + +D +
Sbjct: 303 PDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSME-YVSRHAIDGKFVFVDQRATAILA 361
Query: 285 RTGWEDLVRKCIYAFFQPQ-GREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTK 343
E L C F Q G RQ+ Q TR ++ Y+F + DG+ ++ ++
Sbjct: 362 YLPQELLGTSCYEYFHQDDIGHLAECHRQVLQ---TREKITTNCYKFKIKDGSFITLRSR 418
>gi|22027471 neuronal PAS domain protein 2 [Homo sapiens]
Length = 824
Score = 79.3 bits (194), Expect = 2e-14
Identities = 83/354 (23%), Positives = 145/354 (40%), Gaps = 36/354 (10%)
Query: 29 SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS 88
+ +EK+RR+Q N ++EL+ +L N K DK +L+K + +Q K E
Sbjct: 15 NKSEKKRRDQFNVLIKELSSMLPGNTR-------KMDKTTVLEKVIGFLQ--KHNEVSAQ 65
Query: 89 TTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQ 148
T D+Q+ S + E L+LEALDGF V +G I++VS+++T LG+
Sbjct: 66 TEICDIQQDWKPS----FLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPLLGHLP 121
Query: 149 EELMNTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRML---IHPPD 205
++M+ ++ + L +H+E K L LV P P+ + F C +L ++P +
Sbjct: 122 SDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLLRGSLNPKE 181
Query: 206 EPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQSCLICIAR--------RLPRPPAI- 256
P E + + V P D + C + + + RL P +
Sbjct: 182 FPTYEYIKFVGNFRSYN--NVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLATPQFLK 239
Query: 257 ------TGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYA 310
+E F ++ K + +D + G +E ++ Y ++ E
Sbjct: 240 EMCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFE-VLGTSGYDYYHIDDLE--LL 296
Query: 311 RQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMGIHII 364
+ Q +M G S YRF+ + T + Y Q FI+ H +
Sbjct: 297 ARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSV 350
>gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2
[Homo sapiens]
Length = 735
Score = 74.3 bits (181), Expect = 8e-13
Identities = 80/357 (22%), Positives = 147/357 (41%), Gaps = 41/357 (11%)
Query: 1 MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSL 60
M G G ++D S +RK D S RR +E++ ELA L ++
Sbjct: 1 MEGAG-GANDKKKISSERRKEKSRDAARS-----RRSKESEVFYELAHQLPLP----HNV 50
Query: 61 SVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEAL 120
S DK +++ T+ +++ K ++ +DD+ K + L+AL
Sbjct: 51 SSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDM--------------KAQMNCFYLKAL 96
Query: 121 DGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNG 180
DGF V+ +G ++++S+NV Y+G Q EL SV+ H DH E + L + NG
Sbjct: 97 DGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHR---NG 153
Query: 181 VPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQC---FTVSQPKSIQED-- 235
+ + + +F RM T N ++ ++V+ C V S Q
Sbjct: 154 LV-KKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSA-TWKVLHCTGHIHVYDTNSNQPQCG 211
Query: 236 -GEDFQSCLICIARRLPRPPAI---TGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDL 291
+ +CL+ I +P P I ++F+++ K D G E+L
Sbjct: 212 YKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEP-EEL 270
Query: 292 VRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCY 348
+ + IY ++ + + + ++ T+G ++ YR + G + T+ + Y
Sbjct: 271 LGRSIYEYY--HALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIY 325
>gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1
[Homo sapiens]
Length = 826
Score = 74.3 bits (181), Expect = 8e-13
Identities = 80/357 (22%), Positives = 147/357 (41%), Gaps = 41/357 (11%)
Query: 1 MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSL 60
M G G ++D S +RK D S RR +E++ ELA L ++
Sbjct: 1 MEGAG-GANDKKKISSERRKEKSRDAARS-----RRSKESEVFYELAHQLPLP----HNV 50
Query: 61 SVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEAL 120
S DK +++ T+ +++ K ++ +DD+ K + L+AL
Sbjct: 51 SSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDM--------------KAQMNCFYLKAL 96
Query: 121 DGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNG 180
DGF V+ +G ++++S+NV Y+G Q EL SV+ H DH E + L + NG
Sbjct: 97 DGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHR---NG 153
Query: 181 VPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQC---FTVSQPKSIQED-- 235
+ + + +F RM T N ++ ++V+ C V S Q
Sbjct: 154 LV-KKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSA-TWKVLHCTGHIHVYDTNSNQPQCG 211
Query: 236 -GEDFQSCLICIARRLPRPPAI---TGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDL 291
+ +CL+ I +P P I ++F+++ K D G E+L
Sbjct: 212 YKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEP-EEL 270
Query: 292 VRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCY 348
+ + IY ++ + + + ++ T+G ++ YR + G + T+ + Y
Sbjct: 271 LGRSIYEYY--HALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIY 325
>gi|30795242 aryl hydrocarbon receptor nuclear translocator isoform
3 [Homo sapiens]
Length = 774
Score = 74.3 bits (181), Expect = 8e-13
Identities = 96/421 (22%), Positives = 172/421 (40%), Gaps = 68/421 (16%)
Query: 29 SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS 88
S E+RRR + Y+ EL+++ + +L+ KPDK IL+ V MK + +
Sbjct: 80 SEIERRRRNKMTAYITELSDM----VPTCSALARKPDKLTILRMAVSH---MKSLRGTGN 132
Query: 89 TTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCE-GRIVFVSENVTSYLGYN 147
T+ D K + + L L+LEA DGF F+V+CE GR+V+VS++VT L
Sbjct: 133 TSTDGSYKPSF-------LTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQP 185
Query: 148 QEELMNTSVYSILHVGD------HAEFVKNLLPKSLVN---------GVPWPQEATRRNS 192
Q E +++Y +H D +N L +++ G +
Sbjct: 186 QSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSR 245
Query: 193 HTFNCRMLIHPPD-EPGTENQEACQR----------------YEVMQC---------FTV 226
+F CRM +P + N+ + R + V+ C V
Sbjct: 246 RSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGV 305
Query: 227 SQPKSIQEDGEDFQSCLICIAR-RLPRPPAITGVES------FMTKQDTTGKIISIDTSS 279
S P E G+ + CL+ I R ++ P T + + F+++ + G +D
Sbjct: 306 SLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRC 365
Query: 280 LRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVM-TRGTASSPSYRFILNDGTML 338
+ G ++L+ K I F P+ ++ R FQ+V+ +G S +RF + L
Sbjct: 366 VATVGYQP-QELLGKNIVEFCHPEDQQ--LLRDSFQQVVKLKGQVLSVMFRFRSKNQEWL 422
Query: 339 SAHTKCKLCYPQSPDMQPFIMGIHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAH 398
T D +I+ + + ++S P+ ++ + P++ P+ N +
Sbjct: 423 WMRTSSFTFQNPYSDEIEYIICTN-TNVKNSSQEPRPTLSNTIQRPQLGPTANLPLEMGS 481
Query: 399 G 399
G
Sbjct: 482 G 482
Score = 36.2 bits (82), Expect = 0.23
Identities = 70/299 (23%), Positives = 98/299 (32%), Gaps = 42/299 (14%)
Query: 1050 APNQLRLQLQ-QRLQGQQQLIHQNRQAILNQFAATAPVGINMRSGMQQQITPQPPLNAQM 1108
AP Q + Q + + G+ L N ++ T P + + L AQ
Sbjct: 485 APRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEH-------SKPLEKSDGLFAQD 537
Query: 1109 LAQRQRELYSQQHRQRQLIQQQRAMLMRQQSF--GNNLPPS---------SGL--PVQMG 1155
R E+Y + + + QQ F GN PP+ SGL PV +
Sbjct: 538 RDPRFSEIYHNINADQSKGISSSTVPATQQLFSQGNTFPPTPRPAENFRNSGLAPPVTIV 597
Query: 1156 NPRLPQG---APQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLANRNSMVSRGMTGN 1212
P G A P G P P + S FS +A+ R S
Sbjct: 598 QPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQATAKTRTS--------- 648
Query: 1213 IGGQFGTG-INPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPIPPPQSSLLQQT 1271
QFG G + PGA G A + + GS+ P Q++ QT
Sbjct: 649 ---QFGVGSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRGSNFAP---ETGQTAGQFQT 702
Query: 1272 PPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVSMAGGNTNVQN 1330
A G WQ + + S+ QP QPG +SM G +N N
Sbjct: 703 RTAEGVGV--WPQWQGQQPHHRSSSSEQHVQQPPAQQPGQPEVFQEMLSMLGDQSNSYN 759
Score = 31.6 bits (70), Expect = 5.8
Identities = 47/230 (20%), Positives = 82/230 (35%), Gaps = 20/230 (8%)
Query: 1144 LPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLANRNS 1203
L P++ LP++MG+ +L AP+Q PG ++ SQ+ + +
Sbjct: 469 LGPTANLPLEMGSGQL---APRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSK 525
Query: 1204 MVSRGMTGNIGGQFGTGINPQMQQ-----NVFQYPG--AGMVPQGEANFAPSLSPGSSMV 1256
+ + G F +P+ + N Q G + VP + F S G++
Sbjct: 526 PLEKS-----DGLFAQDRDPRFSEIYHNINADQSKGISSSTVPATQQLF----SQGNTFP 576
Query: 1257 PMPIPPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMS 1316
P P P PP + Q I ++ +Q TP ++
Sbjct: 577 PTPRPAENFRNSGLAPPVTIVQPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQ 636
Query: 1317 I-TVSMAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTG 1365
+ T + A T+ + SS+ +PG T P P+L + G
Sbjct: 637 VATQATAKTRTSQFGVGSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRG 686
>gi|4502231 aryl hydrocarbon receptor nuclear translocator isoform 1
[Homo sapiens]
Length = 789
Score = 74.3 bits (181), Expect = 8e-13
Identities = 96/421 (22%), Positives = 172/421 (40%), Gaps = 68/421 (16%)
Query: 29 SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS 88
S E+RRR + Y+ EL+++ + +L+ KPDK IL+ V MK + +
Sbjct: 95 SEIERRRRNKMTAYITELSDM----VPTCSALARKPDKLTILRMAVSH---MKSLRGTGN 147
Query: 89 TTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCE-GRIVFVSENVTSYLGYN 147
T+ D K + + L L+LEA DGF F+V+CE GR+V+VS++VT L
Sbjct: 148 TSTDGSYKPSF-------LTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQP 200
Query: 148 QEELMNTSVYSILHVGD------HAEFVKNLLPKSLVN---------GVPWPQEATRRNS 192
Q E +++Y +H D +N L +++ G +
Sbjct: 201 QSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSR 260
Query: 193 HTFNCRMLIHPPD-EPGTENQEACQR----------------YEVMQC---------FTV 226
+F CRM +P + N+ + R + V+ C V
Sbjct: 261 RSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGV 320
Query: 227 SQPKSIQEDGEDFQSCLICIAR-RLPRPPAITGVES------FMTKQDTTGKIISIDTSS 279
S P E G+ + CL+ I R ++ P T + + F+++ + G +D
Sbjct: 321 SLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRC 380
Query: 280 LRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVM-TRGTASSPSYRFILNDGTML 338
+ G ++L+ K I F P+ ++ R FQ+V+ +G S +RF + L
Sbjct: 381 VATVGYQP-QELLGKNIVEFCHPEDQQ--LLRDSFQQVVKLKGQVLSVMFRFRSKNQEWL 437
Query: 339 SAHTKCKLCYPQSPDMQPFIMGIHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAH 398
T D +I+ + + ++S P+ ++ + P++ P+ N +
Sbjct: 438 WMRTSSFTFQNPYSDEIEYIICTN-TNVKNSSQEPRPTLSNTIQRPQLGPTANLPLEMGS 496
Query: 399 G 399
G
Sbjct: 497 G 497
Score = 36.2 bits (82), Expect = 0.23
Identities = 70/299 (23%), Positives = 98/299 (32%), Gaps = 42/299 (14%)
Query: 1050 APNQLRLQLQ-QRLQGQQQLIHQNRQAILNQFAATAPVGINMRSGMQQQITPQPPLNAQM 1108
AP Q + Q + + G+ L N ++ T P + + L AQ
Sbjct: 500 APRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEH-------SKPLEKSDGLFAQD 552
Query: 1109 LAQRQRELYSQQHRQRQLIQQQRAMLMRQQSF--GNNLPPS---------SGL--PVQMG 1155
R E+Y + + + QQ F GN PP+ SGL PV +
Sbjct: 553 RDPRFSEIYHNINADQSKGISSSTVPATQQLFSQGNTFPPTPRPAENFRNSGLAPPVTIV 612
Query: 1156 NPRLPQG---APQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLANRNSMVSRGMTGN 1212
P G A P G P P + S FS +A+ R S
Sbjct: 613 QPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQATAKTRTS--------- 663
Query: 1213 IGGQFGTG-INPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPIPPPQSSLLQQT 1271
QFG G + PGA G A + + GS+ P Q++ QT
Sbjct: 664 ---QFGVGSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRGSNFAP---ETGQTAGQFQT 717
Query: 1272 PPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVSMAGGNTNVQN 1330
A G WQ + + S+ QP QPG +SM G +N N
Sbjct: 718 RTAEGVGV--WPQWQGQQPHHRSSSSEQHVQQPPAQQPGQPEVFQEMLSMLGDQSNSYN 774
Score = 31.6 bits (70), Expect = 5.8
Identities = 47/230 (20%), Positives = 82/230 (35%), Gaps = 20/230 (8%)
Query: 1144 LPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLANRNS 1203
L P++ LP++MG+ +L AP+Q PG ++ SQ+ + +
Sbjct: 484 LGPTANLPLEMGSGQL---APRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSK 540
Query: 1204 MVSRGMTGNIGGQFGTGINPQMQQ-----NVFQYPG--AGMVPQGEANFAPSLSPGSSMV 1256
+ + G F +P+ + N Q G + VP + F S G++
Sbjct: 541 PLEKS-----DGLFAQDRDPRFSEIYHNINADQSKGISSSTVPATQQLF----SQGNTFP 591
Query: 1257 PMPIPPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMS 1316
P P P PP + Q I ++ +Q TP ++
Sbjct: 592 PTPRPAENFRNSGLAPPVTIVQPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQ 651
Query: 1317 I-TVSMAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTG 1365
+ T + A T+ + SS+ +PG T P P+L + G
Sbjct: 652 VATQATAKTRTSQFGVGSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRG 701
>gi|31745180 aryl hydrocarbon receptor nuclear translocator-like 2
[Homo sapiens]
Length = 636
Score = 73.9 bits (180), Expect = 1e-12
Identities = 90/373 (24%), Positives = 158/373 (42%), Gaps = 57/373 (15%)
Query: 7 SSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDK 66
SS H+ K S TEKRRR++ N +EEL SA I + ++ K DK
Sbjct: 91 SSGSRVEDGEHQVKMKAFREAHSQTEKRRRDKMNNLIEEL----SAMIPQCNPMARKLDK 146
Query: 67 CKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFV 126
+L+ V ++ +K + T+ V S+ ++ L L+L+ +GF FV
Sbjct: 147 LTVLRMAVQHLRSLKGL------TNSYVG----SNYRPSFLQDNELRHLILKTAEGFLFV 196
Query: 127 VNCE-GRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLP------KSLVN 179
V CE G+I+FVS++V+ L Y+Q L S++ LH D A+ + L + L++
Sbjct: 197 VGCERGKILFVSKSVSKILNYDQASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREKLID 256
Query: 180 GVPWPQEATRRNS----------HTFNCRM---LIHPPDEPG---TENQEACQRYEVMQC 223
Q + ++ +F CR+ I +E G ++ +++ + C
Sbjct: 257 AKTGLQVHSNLHAGRTRVYSGSRRSFFCRIKSCKISVKEEHGCLPNSKKKEHRKFYTIHC 316
Query: 224 --FTVSQPKSI---------QEDGEDFQSCLICIARRLPR-PPAITG-----VESFMTKQ 266
+ S P +I ++D +F +CL+ I R P P +G F+T+
Sbjct: 317 TGYLRSWPPNIVGMEEERNSKKDNSNF-TCLVAIGRLQPYIVPQNSGEINVKPTEFITRF 375
Query: 267 DTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSP 326
GK + +D + G E L C F Q + + + ++ +
Sbjct: 376 AVNGKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHNNLTDKHKAV--LQSKEKILTD 433
Query: 327 SYRFILNDGTMLS 339
SY+F DG+ ++
Sbjct: 434 SYKFRAKDGSFVT 446
>gi|115430245 arylhydrocarbon receptor repressor [Homo sapiens]
Length = 719
Score = 72.8 bits (177), Expect = 2e-12
Identities = 51/164 (31%), Positives = 81/164 (49%), Gaps = 10/164 (6%)
Query: 29 SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMK--RMEQE 86
S+ KR R++ N L+ LA LL I L DK +L+ +V +++ ++ QE
Sbjct: 34 SNPSKRHRDRLNAELDHLASLLPFPPDIISKL----DKLSVLRLSVSYLRVKSFFQVVQE 89
Query: 87 KSTTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGY 146
+S+ S G LLLE+L+GF VV+ EG I + S + YLG+
Sbjct: 90 QSSRQPAAGAPSPGDSCPLAGSAVLEGRLLLESLNGFALVVSAEGTIFYASATIVDYLGF 149
Query: 147 NQEELMNTSVYSILHVGDHAEFVKNLL----PKSLVNGVPWPQE 186
+Q ++M+ ++Y +HV D +F + L P +V G P P E
Sbjct: 150 HQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQPPPLE 193
>gi|30795240 aryl hydrocarbon receptor nuclear translocator isoform
2 [Homo sapiens]
Length = 328
Score = 71.6 bits (174), Expect = 5e-12
Identities = 46/137 (33%), Positives = 72/137 (52%), Gaps = 15/137 (10%)
Query: 29 SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS 88
S E+RRR + Y+ EL+++ + +L+ KPDK IL+ V MK + +
Sbjct: 95 SEIERRRRNKMTAYITELSDM----VPTCSALARKPDKLTILRMAVSH---MKSLRGTGN 147
Query: 89 TTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCE-GRIVFVSENVTSYLGYN 147
T+ D K + + L L+LEA DGF F+V+CE GR+V+VS++VT L
Sbjct: 148 TSTDGSYKPSF-------LTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQP 200
Query: 148 QEELMNTSVYSILHVGD 164
Q E +++Y +H D
Sbjct: 201 QSEWFGSTLYDQVHPDD 217
>gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens]
Length = 901
Score = 71.6 bits (174), Expect = 5e-12
Identities = 46/152 (30%), Positives = 77/152 (50%), Gaps = 16/152 (10%)
Query: 33 KRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDD 92
+ RR +EN ELA+LL + L DK I++ T+ +++ Q +
Sbjct: 31 RSRRGKENFEFYELAKLLPLPAAITSQL----DKASIIRLTISYLKMRDFANQGDPPWNL 86
Query: 93 DVQKSDISSSSQGVIEKES------------LGPLLLEALDGFFFVVNCEGRIVFVSENV 140
++ ++S +G + S LG +L++LDGF F +N EG+ +++SE V
Sbjct: 87 RMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLYISETV 146
Query: 141 TSYLGYNQEELMNTSVYSILHVGDHAEFVKNL 172
+ YLG +Q EL +SV+ +H GDH E + L
Sbjct: 147 SIYLGLSQVELTGSSVFDYVHPGDHVEMAEQL 178
>gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a
[Homo sapiens]
Length = 667
Score = 70.5 bits (171), Expect = 1e-11
Identities = 83/380 (21%), Positives = 149/380 (39%), Gaps = 42/380 (11%)
Query: 33 KRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDD 92
+ RR QE + L +LA L +S DK I++ T+ +++ +
Sbjct: 22 RSRRSQETEVLYQLAHTLPF----ARGVSAHLDKASIMRLTISYLRMHRLCAA------- 70
Query: 93 DVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELM 152
+Q E L L+AL+GF V+ EG + ++SENV+ +LG +Q EL+
Sbjct: 71 -------GEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELI 123
Query: 153 NTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPDEPGTENQ 212
S++ +H D E L P+ ++ ++ F+ RM T N
Sbjct: 124 GHSIFDFIHPCDQEELQDALTPQQTLS----RRKVEAPTERCFSLRMKSTLTSRGRTLNL 179
Query: 213 EACQRYEVMQCF--------TVSQPKSIQEDGEDFQSCLICIARRLPRPPAI---TGVES 261
+A ++V+ C + D E CL+ I +P P ++ G +
Sbjct: 180 KAA-TWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGA 238
Query: 262 FMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRG 321
F+++ K D AG + +DL+ Y + + + ++++G
Sbjct: 239 FLSRHSLDMKFTYCDDRIAEVAGYSP-DDLIGCSAYEYI--HALDSDAVSKSIHTLLSKG 295
Query: 322 TASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMGIH--IIDREHSGL---SPQDD 376
A + YRF+ G L T+ + I+ +H I E +G+ Q +
Sbjct: 296 QAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTE 355
Query: 377 TNSGMSIPRVNPSVNPSISP 396
+S I R PS + +P
Sbjct: 356 QHSRRPIQRGAPSQKDTPNP 375
>gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c
[Homo sapiens]
Length = 669
Score = 70.5 bits (171), Expect = 1e-11
Identities = 83/380 (21%), Positives = 149/380 (39%), Gaps = 42/380 (11%)
Query: 33 KRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDD 92
+ RR QE + L +LA L +S DK I++ T+ +++ +
Sbjct: 24 RSRRSQETEVLYQLAHTLPF----ARGVSAHLDKASIMRLTISYLRMHRLCAA------- 72
Query: 93 DVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELM 152
+Q E L L+AL+GF V+ EG + ++SENV+ +LG +Q EL+
Sbjct: 73 -------GEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELI 125
Query: 153 NTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPDEPGTENQ 212
S++ +H D E L P+ ++ ++ F+ RM T N
Sbjct: 126 GHSIFDFIHPCDQEELQDALTPQQTLS----RRKVEAPTERCFSLRMKSTLTSRGRTLNL 181
Query: 213 EACQRYEVMQCF--------TVSQPKSIQEDGEDFQSCLICIARRLPRPPAI---TGVES 261
+A ++V+ C + D E CL+ I +P P ++ G +
Sbjct: 182 KAA-TWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGA 240
Query: 262 FMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRG 321
F+++ K D AG + +DL+ Y + + + ++++G
Sbjct: 241 FLSRHSLDMKFTYCDDRIAEVAGYSP-DDLIGCSAYEYI--HALDSDAVSKSIHTLLSKG 297
Query: 322 TASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMGIH--IIDREHSGL---SPQDD 376
A + YRF+ G L T+ + I+ +H I E +G+ Q +
Sbjct: 298 QAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTE 357
Query: 377 TNSGMSIPRVNPSVNPSISP 396
+S I R PS + +P
Sbjct: 358 QHSRRPIQRGAPSQKDTPNP 377
>gi|4502003 aryl hydrocarbon receptor [Homo sapiens]
Length = 848
Score = 69.7 bits (169), Expect = 2e-11
Identities = 46/160 (28%), Positives = 82/160 (51%), Gaps = 16/160 (10%)
Query: 20 KGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQL 79
K P + + S+ KR R++ N L+ LA LL I+ L DK +L+ +V ++
Sbjct: 24 KPIPAEGIKSNPSKRHRDRLNTELDRLASLLPFPQDVINKL----DKLSVLRLSVSYLRA 79
Query: 80 -------MKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGR 132
+K E++ D+ + ++ +G+ +E G LL+AL+GF VV +
Sbjct: 80 KSFFDVALKSSPTERNGGQDNCRAANFR---EGLNLQE--GEFLLQALNGFVLVVTTDAL 134
Query: 133 IVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNL 172
+ + S + YLG+ Q ++++ SVY ++H D AEF + L
Sbjct: 135 VFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQL 174
>gi|22027482 neuronal PAS domain protein 1 [Homo sapiens]
Length = 590
Score = 68.6 bits (166), Expect = 4e-11
Identities = 47/168 (27%), Positives = 88/168 (52%), Gaps = 12/168 (7%)
Query: 33 KRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMK--RMEQEKSTT 90
+ RR +EN ELA+LL ++S + DK I++ +V ++L + +
Sbjct: 55 RSRRGKENLEFFELAKLLPLP----GAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGL 110
Query: 91 DDDVQKSDISSSSQGV------IEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYL 144
+ ++ +G + ++ LG +L++LDGF F +N EG+ +++SE V+ YL
Sbjct: 111 RAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYL 170
Query: 145 GYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNS 192
G +Q E+ +SV+ +H GDH+E ++ L ++ G P P + +S
Sbjct: 171 GLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSS 218
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 67.8 bits (164), Expect = 7e-11
Identities = 85/372 (22%), Positives = 149/372 (40%), Gaps = 10/372 (2%)
Query: 375 DDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINRQQSSDLHSSSHSNS 434
D +NS S + S + S + + S + SNS+ S + SD SS+ S+S
Sbjct: 802 DSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDS 861
Query: 435 SNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTGISLAQFMSPRRQVT 494
SNS S S S + + SS SS+ S + N+S + + S + S +
Sbjct: 862 SNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSD----S 917
Query: 495 SGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTSLQGMNEGPNNSVGF 554
S + N+S N S S+ + S+ ++N+ SN +S + N+S
Sbjct: 918 SNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSS 977
Query: 555 SASSPVLRQMSSQNSPSRLNIQPA-KAESKDNKEIASILNEMIQSDNSSSDGKPLDSGLL 613
+S+ SS +S S + + ++S D+ + + N S++S S S
Sbjct: 978 DSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSS 1037
Query: 614 HNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSCTGTSNSASANSSG 673
++D DS S S ++ + + D + +S+S++++ S
Sbjct: 1038 DSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSS 1097
Query: 674 GSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVSVTGQVQGNSSIKL 733
S SS SS + + SD + S D DS+++S S +SS
Sbjct: 1098 DSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSS--- 1154
Query: 734 ELDASKKKESKD 745
D+S +S D
Sbjct: 1155 --DSSDSSDSSD 1164
Score = 63.2 bits (152), Expect = 2e-09
Identities = 90/391 (23%), Positives = 150/391 (38%), Gaps = 11/391 (2%)
Query: 365 DREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINRQQSS 424
D + S S D++ + S + S S + S S+S S+ N SS
Sbjct: 592 DSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSS 651
Query: 425 D----LHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTG 480
D SS+ SNSS+S S S S + + SS SSN S + ++S +
Sbjct: 652 DNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSD 711
Query: 481 ISLAQFMSPRR-----QVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSN 535
S + S S ++ ++S + S+ SS +S + N+++ S S+
Sbjct: 712 SSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSS 771
Query: 536 IPVTSLQGMNEG-PNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNE 594
S N N+S S SS S NS + + N +S ++
Sbjct: 772 DSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSD 831
Query: 595 MIQSDNSSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSC 654
S NSS DS ++D + DS S S ++ ++ ++
Sbjct: 832 SSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNS 891
Query: 655 KDVLSCTGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDS 714
D + +S+S S++SS S SS SS + + SD + S D DS
Sbjct: 892 SDSSDSSNSSDSDSSDSSNSS-DSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDS 950
Query: 715 ASTSVSVTGQVQGNSSIKLELDASKKKESKD 745
+++S S NSS + ++S +S +
Sbjct: 951 SNSSDSSNSSDSSNSSDSSDSNSSDSSDSSN 981
Score = 59.3 bits (142), Expect = 3e-08
Identities = 77/369 (20%), Positives = 144/369 (39%), Gaps = 20/369 (5%)
Query: 409 SNSNMVSTRINRQQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPS 468
S+++ S+ + SSD +SSS S+SS+S S S +N + + + S S+ S
Sbjct: 557 SSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDS 616
Query: 469 LNLNNSPMEGTGISLAQFMSPRRQVTSGLATRPRMPN----------NSFPPNISTLSSP 518
+ ++S + + S + +S + N NS + S+ SS
Sbjct: 617 SDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSD 676
Query: 519 VGMTSSACNNNNRSYSNIPVTSLQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPA 578
+S + N+++ S S+ S + + ++ S SS SS + S +
Sbjct: 677 SSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSD 736
Query: 579 KAESKDNKEIASILNEMIQSDNSSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLT 638
+ S D+ + + N SD+S S S ++D +S S S
Sbjct: 737 SSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSD 796
Query: 639 TTAEQQLRHADIDTSCKDVLSCTGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGS 698
++ ++ + D +++S S+NSS S S+ S ++ +GS
Sbjct: 797 SSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSD-----SSDGS 851
Query: 699 PSDITTLSVEPDKKDSASTSVSVTGQVQGNSSIKLELDASKKKESKDHQLLRYLLDKDEK 758
SD + S + DS+ +S S +SS D+++ S D D D
Sbjct: 852 DSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSS-----DSNESSNSSDSSDSSNSSDSDSS 906
Query: 759 DLRSTPNLS 767
D ++ + S
Sbjct: 907 DSSNSSDSS 915
Score = 55.8 bits (133), Expect = 3e-07
Identities = 86/377 (22%), Positives = 148/377 (39%), Gaps = 15/377 (3%)
Query: 375 DDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINRQQSSDLHSSSHSN- 433
+ +NS S N S + S ++ S + S+S+ S + SSD +SS S+
Sbjct: 887 ESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSD 946
Query: 434 ---SSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTGISLAQFMSPR 490
SSNS S S S N + + SS SS+ S + ++S + S S
Sbjct: 947 SSDSSNSSDSSNSSDSS----NSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSN 1002
Query: 491 RQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTSLQGMNEGPNN 550
+S + N+S N S S+ + S+ ++++ S+ +S + ++
Sbjct: 1003 SSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSD 1062
Query: 551 SVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDNSSSDGKPLDS 610
S S SS SS +S S + + + + N +S ++ S +SS DS
Sbjct: 1063 SSDSSDSSD-----SSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDS 1117
Query: 611 GLLHNNDRLSD-GDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSCTGTSNSASA 669
N+ SD DS S S ++ + + D + +S+S+ +
Sbjct: 1118 SDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDS 1177
Query: 670 NSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVSVTGQVQGNS 729
++S S SS SS + SD + S D DS+ +S S +S
Sbjct: 1178 SNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDS 1237
Query: 730 SIKLE-LDASKKKESKD 745
S + D+S +S D
Sbjct: 1238 SDSSDSSDSSNSSDSSD 1254
Score = 53.5 bits (127), Expect = 1e-06
Identities = 82/386 (21%), Positives = 145/386 (37%), Gaps = 23/386 (5%)
Query: 365 DREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINRQQSS 424
D S S D++ + + S N S S S++ SNS+ S + SS
Sbjct: 893 DSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSES----SNSSDNSNSSDSSNSSDSSDSS 948
Query: 425 DLHSSS-HSNSSNSQGSFGCSPGSQIVANVALNQGQAS----SQSSNPSLNLNNSPMEGT 479
D +SS SNSS+S S S + ++ + N +S S S+ S + +NS
Sbjct: 949 DSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSD 1008
Query: 480 GISLAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVT 539
+ + S ++ ++S + S+ SS +S + N+++ S S+
Sbjct: 1009 SSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSD 1068
Query: 540 SLQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSD 599
S + ++ S+ S S + S + ++S D+ + + N SD
Sbjct: 1069 SSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSD 1128
Query: 600 NSSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLS 659
+S S S ++D DS S S ++ + + D
Sbjct: 1129 SSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSD 1188
Query: 660 CTGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSV 719
+ +S+S+ ++ S S SS SS + SD + S D +S+ +S
Sbjct: 1189 SSDSSDSSDSSDSSDSSDSSDSSDSS---------DSSDSSDSSDSSDSSDSNESSDSSD 1239
Query: 720 SVTGQVQGNSSIKLELDASKKKESKD 745
S NSS D+S +S D
Sbjct: 1240 SSDSSDSSNSS-----DSSDSSDSSD 1260
Score = 52.8 bits (125), Expect = 2e-06
Identities = 70/328 (21%), Positives = 136/328 (41%), Gaps = 12/328 (3%)
Query: 420 RQQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGT 479
+ SSD SS SNSS+S S ++ + + SS SS+ + +++ + +
Sbjct: 546 KSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSS 605
Query: 480 GISLAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVT 539
S + S + + + ++S + + SS + S+ N+++ SN +
Sbjct: 606 DSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSN---S 662
Query: 540 SLQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSD 599
S + ++S S+SS S +S N +ES D+ + +S + SD
Sbjct: 663 SNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSN----SSESSDSSD-SSDSDSSDSSD 717
Query: 600 NSSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLS 659
+S+S+ DS +++D +S S S ++ ++ + D
Sbjct: 718 SSNSNSSDSDSS--NSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSD 775
Query: 660 CTGTSNSASANSSGGSCPSSHSSLT--ERHKILHRLLQEGSPSDITTLSVEPDKKDSAST 717
+ +SNS+ +N S S SS SS + + + S SD + S + DS+ +
Sbjct: 776 SSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDS 835
Query: 718 SVSVTGQVQGNSSIKLELDASKKKESKD 745
S S +SS + D+S + +S +
Sbjct: 836 SNSSDSSDSSDSSDGSDSDSSNRSDSSN 863
Score = 49.7 bits (117), Expect = 2e-05
Identities = 67/322 (20%), Positives = 122/322 (37%), Gaps = 8/322 (2%)
Query: 367 EHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINRQQSSDL 426
+ S S D+NS S N S + S + + SS +SN + + S
Sbjct: 961 DSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSS----DSSNSSDSSDSSDSSDSS 1016
Query: 427 HSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTGISLAQF 486
+SS SNSS+S S S S + + SS SSN S + ++S + S
Sbjct: 1017 NSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSS 1076
Query: 487 MSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTSLQGMNE 546
S +S + +NS + S+ SS +S + ++++ S S+ S +
Sbjct: 1077 DSSDSSESSDSSD----SSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDS 1132
Query: 547 GPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDNSSSDGK 606
++ S+ S + S + S + ++S D+ + + N SD+S S
Sbjct: 1133 SDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDS 1192
Query: 607 PLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSCTGTSNS 666
S ++D DS S S ++ + + D + +S+S
Sbjct: 1193 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDS 1252
Query: 667 ASANSSGGSCPSSHSSLTERHK 688
+ ++ S S S+ + K
Sbjct: 1253 SDSSDSSDSTSDSNDESDSQSK 1274
Score = 49.3 bits (116), Expect = 3e-05
Identities = 75/329 (22%), Positives = 130/329 (39%), Gaps = 12/329 (3%)
Query: 423 SSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTGIS 482
+ D +S S +NSS+ + S S+ N + ++G A S+ + + NNS G G +
Sbjct: 474 NDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKG-AEDDDSDSTSDTNNSDSNGNGNN 532
Query: 483 LAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNR----SYSNIPV 538
+ SG ++S + S+ SS + S+ +N++ S S+
Sbjct: 533 ---GNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSD 589
Query: 539 TSLQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDN--KEIASILNEMI 596
+S ++ N+S +S SS +S S+ + ++++S D+ K +S N
Sbjct: 590 SSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSD 649
Query: 597 QSDNSSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKD 656
SDNS S S ++D DS S S ++ + + D
Sbjct: 650 SSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSD 709
Query: 657 VLSCTGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSAS 716
S + +S S +S S SS SS + + SD + S + DS+
Sbjct: 710 SDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSD 769
Query: 717 TSVSVTGQVQGNSSIKLELDASKKKESKD 745
+S S NSS D+S +S D
Sbjct: 770 SSDSSDSSDSSNSSD--SNDSSNSSDSSD 796
Score = 42.0 bits (97), Expect = 0.004
Identities = 62/274 (22%), Positives = 110/274 (40%), Gaps = 10/274 (3%)
Query: 365 DREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINRQQSS 424
D +S S +S S + + S + + S + S+S+ S + +SS
Sbjct: 1026 DSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESS 1085
Query: 425 DLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTGISLA 484
D SS SNSS+S S S S + + SS SS+ S + ++S + S
Sbjct: 1086 D--SSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSD 1143
Query: 485 QFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTSLQGM 544
S +S + ++S + S SS +S + ++++ S S+ S
Sbjct: 1144 SSDSSESSDSSDSSDSSDSSDSSDSSDSSD-SSDSSNSSDSSDSSDSSDSSDSSDSSDSS 1202
Query: 545 NEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDNSSSD 604
+ ++ S+ S S + S N ++S D+ + ++ + SD+S S
Sbjct: 1203 DSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDST 1262
Query: 605 GKPLD-------SGLLHNNDRLSDGDSKYSQTSH 631
D SG +NN SD DS+ S ++H
Sbjct: 1263 SDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNH 1296
Score = 36.2 bits (82), Expect = 0.23
Identities = 64/317 (20%), Positives = 111/317 (35%), Gaps = 41/317 (12%)
Query: 499 TRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTSLQGMNEGPNNSVGFSASS 558
T+ + N P S + VG +++ ++N+ Y + + PN+S + +
Sbjct: 416 TQGEVVNIEGPGQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGND 475
Query: 559 PVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDNSSSDGKPLDSGLLHNNDR 618
+ S NS SR + ESKDN + +S+SD DS NN
Sbjct: 476 DANSE-SDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGN 534
Query: 619 LSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSCTGTSNSASANSSGGSCPS 678
D D S D+S D S +++S S++SS
Sbjct: 535 -DDNDKSDSGKGKS------------------DSSDSD--SSDSSNSSDSSDSSDSDSSD 573
Query: 679 SHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVSVTGQVQGNSSIKLELDAS 738
S+SS S SD S + D DS+ + S + +S D+S
Sbjct: 574 SNSS---------------SDSD----SSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSS 614
Query: 739 KKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQMDPCNTNPTPMTKPTPEE 798
+S D + + D D S + S + + + D N++ + + + +
Sbjct: 615 DSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDS 674
Query: 799 IKLEAQSQFTADLDQFD 815
+ S + D D
Sbjct: 675 SDSSSSSDSSNSSDSSD 691
>gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b
[Homo sapiens]
Length = 613
Score = 67.8 bits (164), Expect = 7e-11
Identities = 69/303 (22%), Positives = 123/303 (40%), Gaps = 24/303 (7%)
Query: 110 ESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFV 169
E L L+AL+GF V+ EG + ++SENV+ +LG +Q EL+ S++ +H D E
Sbjct: 27 EPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQ 86
Query: 170 KNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCF----- 224
L P+ ++ ++ F+ RM T N +A ++V+ C
Sbjct: 87 DALTPQQTLS----RRKVEAPTERCFSLRMKSTLTSRGRTLNLKAA-TWKVLNCSGHMRA 141
Query: 225 ---TVSQPKSIQEDGEDFQSCLICIARRLPRPPAI---TGVESFMTKQDTTGKIISIDTS 278
+ D E CL+ I +P P ++ G +F+++ K D
Sbjct: 142 YKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDR 201
Query: 279 SLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTML 338
AG + +DL+ Y + + + ++++G A + YRF+ G L
Sbjct: 202 IAEVAGYSP-DDLIGCSAYEYI--HALDSDAVSKSIHTLLSKGQAVTGQYRFLARSGGYL 258
Query: 339 SAHTKCKLCYPQSPDMQPFIMGIH--IIDREHSGL---SPQDDTNSGMSIPRVNPSVNPS 393
T+ + I+ +H I E +G+ Q + +S I R PS +
Sbjct: 259 WTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQRGAPSQKDT 318
Query: 394 ISP 396
+P
Sbjct: 319 PNP 321
>gi|40254439 endothelial PAS domain protein 1 [Homo sapiens]
Length = 870
Score = 67.4 bits (163), Expect = 9e-11
Identities = 75/325 (23%), Positives = 135/325 (41%), Gaps = 34/325 (10%)
Query: 35 RREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDV 94
RR +E + ELA L S+S DK I++ + ++ K + S + +
Sbjct: 26 RRSKETEVFYELAHELPLP----HSVSSHLDKASIMRLAISFLRTHKLLSSVCSENESEA 81
Query: 95 QKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNT 154
+ + + L L+AL+GF VV +G ++F+SEN++ ++G Q EL
Sbjct: 82 EAD------------QQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMGLTQVELTGH 129
Query: 155 SVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNS-HTFNCRMLIHPPDEPGTENQE 213
S++ H DH E +NL SL NG + +++ ++ F RM + T N +
Sbjct: 130 SIFDFTHPCDHEEIRENL---SLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRGRTVNLK 186
Query: 214 ACQRYEVMQC------FTVSQP-KSIQEDGEDFQSCLICIARRLPRPPAI---TGVESFM 263
+ ++V+ C + P S+ E SCLI + + P + ++F+
Sbjct: 187 SA-TWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLDSKTFL 245
Query: 264 TKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRGTA 323
++ K D G E+L+ + Y F+ E + Q + T+G
Sbjct: 246 SRHSMDMKFTYCDDRITELIGYHP-EELLGRSAYEFYHALDSE--NMTKSHQNLCTKGQV 302
Query: 324 SSPSYRFILNDGTMLSAHTKCKLCY 348
S YR + G + T+ + Y
Sbjct: 303 VSGQYRMLAKHGGYVWLETQGTVIY 327
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.127 0.362
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 61,288,017
Number of Sequences: 37866
Number of extensions: 3197313
Number of successful extensions: 16640
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 90
Number of HSP's successfully gapped in prelim test: 529
Number of HSP's that attempted gapping in prelim test: 13262
Number of HSP's gapped (non-prelim): 2719
length of query: 1440
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1325
effective length of database: 13,892,928
effective search space: 18408129600
effective search space used: 18408129600
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.