Guide to the Human Genome
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Search of human proteins with 22538457

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo
sapiens]
         (1399 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens]  2792   0.0  
gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens]  2768   0.0  
gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens]  2767   0.0  
gi|5729858 nuclear receptor coactivator 2 [Homo sapiens]              587   e-167
gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens]   494   e-139
gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens]   494   e-139
gi|21614542 single-minded homolog 1 [Homo sapiens]                     92   3e-18
gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Ho...    87   1e-16
gi|4758010 clock [Homo sapiens]                                        84   7e-16
gi|4827004 single-minded homolog 2 long isoform [Homo sapiens]         83   2e-15
gi|194239684 single-minded homolog 2 short isoform [Homo sapiens]      83   2e-15
gi|71852582 aryl hydrocarbon receptor nuclear translocator-like ...    81   6e-15
gi|71852580 aryl hydrocarbon receptor nuclear translocator-like ...    81   6e-15
gi|42716311 aryl hydrocarbon receptor nuclear translocator-like ...    81   6e-15
gi|22027471 neuronal PAS domain protein 2 [Homo sapiens]               79   2e-14
gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2 ...    74   8e-13
gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1 [...    74   8e-13
gi|30795242 aryl hydrocarbon receptor nuclear translocator isofo...    74   8e-13
gi|4502231 aryl hydrocarbon receptor nuclear translocator isofor...    74   8e-13
gi|31745180 aryl hydrocarbon receptor nuclear translocator-like ...    74   1e-12
gi|115430245 arylhydrocarbon receptor repressor [Homo sapiens]         73   2e-12
gi|30795240 aryl hydrocarbon receptor nuclear translocator isofo...    72   5e-12
gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens]     72   5e-12
gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a ...    70   1e-11
gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c ...    70   1e-11
gi|4502003 aryl hydrocarbon receptor [Homo sapiens]                    70   2e-11
gi|22027482 neuronal PAS domain protein 1 [Homo sapiens]               69   4e-11
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    68   7e-11
gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b ...    68   7e-11
gi|40254439 endothelial PAS domain protein 1 [Homo sapiens]            67   9e-11

>gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens]
          Length = 1399

 Score = 2792 bits (7238), Expect = 0.0
 Identities = 1399/1399 (100%), Positives = 1399/1399 (100%)

Query: 1    MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSL 60
            MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSL
Sbjct: 1    MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSL 60

Query: 61   SVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEAL 120
            SVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEAL
Sbjct: 61   SVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEAL 120

Query: 121  DGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNG 180
            DGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNG
Sbjct: 121  DGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNG 180

Query: 181  VPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQ 240
            VPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQ
Sbjct: 181  VPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQ 240

Query: 241  SCLICIARRLPRPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFF 300
            SCLICIARRLPRPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFF
Sbjct: 241  SCLICIARRLPRPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFF 300

Query: 301  QPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMG 360
            QPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMG
Sbjct: 301  QPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMG 360

Query: 361  IHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINR 420
            IHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINR
Sbjct: 361  IHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINR 420

Query: 421  QQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTG 480
            QQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTG
Sbjct: 421  QQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTG 480

Query: 481  ISLAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTS 540
            ISLAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTS
Sbjct: 481  ISLAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTS 540

Query: 541  LQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDN 600
            LQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDN
Sbjct: 541  LQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDN 600

Query: 601  SSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSC 660
            SSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSC
Sbjct: 601  SSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSC 660

Query: 661  TGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVS 720
            TGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVS
Sbjct: 661  TGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVS 720

Query: 721  VTGQVQGNSSIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQ 780
            VTGQVQGNSSIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQ
Sbjct: 721  VTGQVQGNSSIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQ 780

Query: 781  MDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQFDQLLPTLEKAAQLPGLCETDRMDGAV 840
            MDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQFDQLLPTLEKAAQLPGLCETDRMDGAV
Sbjct: 781  MDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQFDQLLPTLEKAAQLPGLCETDRMDGAV 840

Query: 841  TSVTIKSEILPASLQSATARPTSRLNRLPELELEAIDNQFGQPGTGDQIPWTNNTVTAIN 900
            TSVTIKSEILPASLQSATARPTSRLNRLPELELEAIDNQFGQPGTGDQIPWTNNTVTAIN
Sbjct: 841  TSVTIKSEILPASLQSATARPTSRLNRLPELELEAIDNQFGQPGTGDQIPWTNNTVTAIN 900

Query: 901  QSKSEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKL 960
            QSKSEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKL
Sbjct: 901  QSKSEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKL 960

Query: 961  VQGGGLDVLSERFPPQQATPPLIMEERPNLYSQPYSSPSPTANLPSPFQGMVRQKPSLGT 1020
            VQGGGLDVLSERFPPQQATPPLIMEERPNLYSQPYSSPSPTANLPSPFQGMVRQKPSLGT
Sbjct: 961  VQGGGLDVLSERFPPQQATPPLIMEERPNLYSQPYSSPSPTANLPSPFQGMVRQKPSLGT 1020

Query: 1021 MPVQVTPPRGAFSPGMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQF 1080
            MPVQVTPPRGAFSPGMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQF
Sbjct: 1021 MPVQVTPPRGAFSPGMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQF 1080

Query: 1081 AATAPVGINMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQLIQQQRAMLMRQQSF 1140
            AATAPVGINMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQLIQQQRAMLMRQQSF
Sbjct: 1081 AATAPVGINMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQLIQQQRAMLMRQQSF 1140

Query: 1141 GNNLPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLAN 1200
            GNNLPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLAN
Sbjct: 1141 GNNLPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLAN 1200

Query: 1201 RNSMVSRGMTGNIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPI 1260
            RNSMVSRGMTGNIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPI
Sbjct: 1201 RNSMVSRGMTGNIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPI 1260

Query: 1261 PPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVS 1320
            PPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVS
Sbjct: 1261 PPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVS 1320

Query: 1321 MAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLKTE 1380
            MAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLKTE
Sbjct: 1321 MAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLKTE 1380

Query: 1381 ADGTQDKKTEEFFSVVTTD 1399
            ADGTQDKKTEEFFSVVTTD
Sbjct: 1381 ADGTQDKKTEEFFSVVTTD 1399


>gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens]
          Length = 1440

 Score = 2768 bits (7176), Expect = 0.0
 Identities = 1388/1398 (99%), Positives = 1391/1398 (99%)

Query: 1    MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSL 60
            MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSL
Sbjct: 1    MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSL 60

Query: 61   SVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEAL 120
            SVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEAL
Sbjct: 61   SVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEAL 120

Query: 121  DGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNG 180
            DGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNG
Sbjct: 121  DGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNG 180

Query: 181  VPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQ 240
            VPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQ
Sbjct: 181  VPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQ 240

Query: 241  SCLICIARRLPRPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFF 300
            SCLICIARRLPRPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFF
Sbjct: 241  SCLICIARRLPRPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFF 300

Query: 301  QPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMG 360
            QPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMG
Sbjct: 301  QPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMG 360

Query: 361  IHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINR 420
            IHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINR
Sbjct: 361  IHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINR 420

Query: 421  QQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTG 480
            QQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTG
Sbjct: 421  QQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTG 480

Query: 481  ISLAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTS 540
            ISLAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTS
Sbjct: 481  ISLAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTS 540

Query: 541  LQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDN 600
            LQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDN
Sbjct: 541  LQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDN 600

Query: 601  SSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSC 660
            SSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSC
Sbjct: 601  SSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSC 660

Query: 661  TGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVS 720
            TGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVS
Sbjct: 661  TGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVS 720

Query: 721  VTGQVQGNSSIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQ 780
            VTGQVQGNSSIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQ
Sbjct: 721  VTGQVQGNSSIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQ 780

Query: 781  MDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQFDQLLPTLEKAAQLPGLCETDRMDGAV 840
            MDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQFDQLLPTLEKAAQLPGLCETDRMDGAV
Sbjct: 781  MDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQFDQLLPTLEKAAQLPGLCETDRMDGAV 840

Query: 841  TSVTIKSEILPASLQSATARPTSRLNRLPELELEAIDNQFGQPGTGDQIPWTNNTVTAIN 900
            TSVTIKSEILPASLQSATARPTSRLNRLPELELEAIDNQFGQPGTGDQIPWTNNTVTAIN
Sbjct: 841  TSVTIKSEILPASLQSATARPTSRLNRLPELELEAIDNQFGQPGTGDQIPWTNNTVTAIN 900

Query: 901  QSKSEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKL 960
            QSKSEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKL
Sbjct: 901  QSKSEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKL 960

Query: 961  VQGGGLDVLSERFPPQQATPPLIMEERPNLYSQPYSSPSPTANLPSPFQGMVRQKPSLGT 1020
            VQGGGLDVLSERFPPQQATPPLIMEERPNLYSQPYSSPSPTANLPSPFQGMVRQKPSLGT
Sbjct: 961  VQGGGLDVLSERFPPQQATPPLIMEERPNLYSQPYSSPSPTANLPSPFQGMVRQKPSLGT 1020

Query: 1021 MPVQVTPPRGAFSPGMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQF 1080
            MPVQVTPPRGAFSPGMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQF
Sbjct: 1021 MPVQVTPPRGAFSPGMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQF 1080

Query: 1081 AATAPVGINMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQLIQQQRAMLMRQQSF 1140
            AATAPVGINMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQLIQQQRAMLMRQQSF
Sbjct: 1081 AATAPVGINMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQLIQQQRAMLMRQQSF 1140

Query: 1141 GNNLPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLAN 1200
            GNNLPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLAN
Sbjct: 1141 GNNLPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLAN 1200

Query: 1201 RNSMVSRGMTGNIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPI 1260
            RNSMVSRGMTGNIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPI
Sbjct: 1201 RNSMVSRGMTGNIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPI 1260

Query: 1261 PPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVS 1320
            PPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVS
Sbjct: 1261 PPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVS 1320

Query: 1321 MAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLKTE 1380
            MAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLKTE
Sbjct: 1321 MAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLKTE 1380

Query: 1381 ADGTQDKKTEEFFSVVTT 1398
            ADGTQ ++ + F  V  T
Sbjct: 1381 ADGTQVQQVQVFADVQCT 1398


>gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens]
          Length = 1441

 Score = 2767 bits (7172), Expect = 0.0
 Identities = 1387/1396 (99%), Positives = 1390/1396 (99%)

Query: 1    MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSL 60
            MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSL
Sbjct: 1    MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSL 60

Query: 61   SVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEAL 120
            SVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEAL
Sbjct: 61   SVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEAL 120

Query: 121  DGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNG 180
            DGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNG
Sbjct: 121  DGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNG 180

Query: 181  VPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQ 240
            VPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQ
Sbjct: 181  VPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQ 240

Query: 241  SCLICIARRLPRPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFF 300
            SCLICIARRLPRPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFF
Sbjct: 241  SCLICIARRLPRPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFF 300

Query: 301  QPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMG 360
            QPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMG
Sbjct: 301  QPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMG 360

Query: 361  IHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINR 420
            IHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINR
Sbjct: 361  IHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINR 420

Query: 421  QQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTG 480
            QQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTG
Sbjct: 421  QQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTG 480

Query: 481  ISLAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTS 540
            ISLAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTS
Sbjct: 481  ISLAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTS 540

Query: 541  LQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDN 600
            LQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDN
Sbjct: 541  LQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDN 600

Query: 601  SSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSC 660
            SSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSC
Sbjct: 601  SSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSC 660

Query: 661  TGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVS 720
            TGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVS
Sbjct: 661  TGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVS 720

Query: 721  VTGQVQGNSSIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQ 780
            VTGQVQGNSSIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQ
Sbjct: 721  VTGQVQGNSSIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQ 780

Query: 781  MDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQFDQLLPTLEKAAQLPGLCETDRMDGAV 840
            MDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQFDQLLPTLEKAAQLPGLCETDRMDGAV
Sbjct: 781  MDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQFDQLLPTLEKAAQLPGLCETDRMDGAV 840

Query: 841  TSVTIKSEILPASLQSATARPTSRLNRLPELELEAIDNQFGQPGTGDQIPWTNNTVTAIN 900
            TSVTIKSEILPASLQSATARPTSRLNRLPELELEAIDNQFGQPGTGDQIPWTNNTVTAIN
Sbjct: 841  TSVTIKSEILPASLQSATARPTSRLNRLPELELEAIDNQFGQPGTGDQIPWTNNTVTAIN 900

Query: 901  QSKSEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKL 960
            QSKSEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKL
Sbjct: 901  QSKSEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKL 960

Query: 961  VQGGGLDVLSERFPPQQATPPLIMEERPNLYSQPYSSPSPTANLPSPFQGMVRQKPSLGT 1020
            VQGGGLDVLSERFPPQQATPPLIMEERPNLYSQPYSSPSPTANLPSPFQGMVRQKPSLGT
Sbjct: 961  VQGGGLDVLSERFPPQQATPPLIMEERPNLYSQPYSSPSPTANLPSPFQGMVRQKPSLGT 1020

Query: 1021 MPVQVTPPRGAFSPGMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQF 1080
            MPVQVTPPRGAFSPGMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQF
Sbjct: 1021 MPVQVTPPRGAFSPGMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQF 1080

Query: 1081 AATAPVGINMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQLIQQQRAMLMRQQSF 1140
            AATAPVGINMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQLIQQQRAMLMRQQSF
Sbjct: 1081 AATAPVGINMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQLIQQQRAMLMRQQSF 1140

Query: 1141 GNNLPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLAN 1200
            GNNLPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLAN
Sbjct: 1141 GNNLPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLAN 1200

Query: 1201 RNSMVSRGMTGNIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPI 1260
            RNSMVSRGMTGNIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPI
Sbjct: 1201 RNSMVSRGMTGNIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPI 1260

Query: 1261 PPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVS 1320
            PPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVS
Sbjct: 1261 PPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVS 1320

Query: 1321 MAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLKTE 1380
            MAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLKTE
Sbjct: 1321 MAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLKTE 1380

Query: 1381 ADGTQDKKTEEFFSVV 1396
            ADGTQ  +  + F+ V
Sbjct: 1381 ADGTQQVQQVQVFADV 1396


>gi|5729858 nuclear receptor coactivator 2 [Homo sapiens]
          Length = 1464

 Score =  587 bits (1514), Expect = e-167
 Identities = 376/891 (42%), Positives = 521/891 (58%), Gaps = 66/891 (7%)

Query: 1   MSGLGDSSSDPANPDSHKRKGSPCDTLASS----TEKRRREQENKYLEELAELLSANISD 56
           MSG+G+++SDP+  ++ KRK  P D L  S    TEKR REQENKY+EELAEL+ AN +D
Sbjct: 1   MSGMGENTSDPSRAETRKRKECP-DQLGPSPKRNTEKRNREQENKYIEELAELIFANFND 59

Query: 57  IDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLL 116
           ID+ + KPDKC ILK+TV QI+ +K  E+  +   D+VQKSD+SS+ QGVI+K++LGP++
Sbjct: 60  IDNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMM 119

Query: 117 LEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKS 176
           LEALDGFFFVVN EG +VFVSENVT YL YNQEELMN SVYSILHVGDH EFVKNLLPKS
Sbjct: 120 LEALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKS 179

Query: 177 LVNGVPWPQEATRRNSHTFNCRMLIHP-PD--EPGTENQEACQRYEVMQCFTVSQPKSIQ 233
           +VNG  W  E  RRNSHTFNCRML+ P PD  E G +NQEA Q+YE MQCF VSQPKSI+
Sbjct: 180 IVNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFAVSQPKSIK 239

Query: 234 EDGEDFQSCLICIARRLP--RPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDL 291
           E+GED QSCLIC+ARR+P    P +   ESF T+QD  GKI S+DTS++RAA + GWEDL
Sbjct: 240 EEGEDLQSCLICVARRVPMKERPVLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDL 299

Query: 292 VRKCIYAFF-QPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQ 350
           VR+CI  F  Q +G   SYA++   EV+ +G A S  YRF L+DGT+++A TK KL   Q
Sbjct: 300 VRRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQ 359

Query: 351 SPDMQPFIMGIHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSN 410
           + +    ++ +H++ RE +      D         +NP    S SPAH    S    P  
Sbjct: 360 TTNEPQLVISLHMLHREQNVCVMNPDLTGQTMGKPLNPI--SSNSPAHQALCSGN--PGQ 415

Query: 411 SNMVSTRINRQQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLN 470
              +S+ IN        +          G FG S G   V+ +       + Q SN +L 
Sbjct: 416 DMTLSSNINFP-----INGPKEQMGMPMGRFGGSGGMNHVSGMQ----ATTPQGSNYALK 466

Query: 471 LNNSPMEGTGISLAQ---FMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACN 527
           +N+      G++  Q    +SPR +++ G+A  PR+P + F P   +L SPVG+ SS   
Sbjct: 467 MNSPSQSSPGMNPGQPTSMLSPRHRMSPGVAGSPRIPPSQFSP-AGSLHSPVGVCSS--T 523

Query: 528 NNNRSYSNIPVTSLQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQP-AKAESKDNK 586
            N+ SY+N  + +LQ ++EG   S+G S +SP L+  + QNSP  +N  P +K  S D+K
Sbjct: 524 GNSHSYTNSSLNALQALSEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSLDSK 583

Query: 587 EIASILNEMIQSDNSSSDGKPLDSGLLHNND---------RLSDGDSKY--SQTSHKLVQ 635
           +   +  E  +     ++           ND           +DG S+   S+   KL+Q
Sbjct: 584 DCFGLYGEPSEGTTGQAESSCHPGEQKETNDPNLPPAVSSERADGQSRLHDSKGQTKLLQ 643

Query: 636 LLTTTAEQQLRHADIDTSCKDVLSCTGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQ 695
           LLTT ++ Q+  + + +S  D       +N  S  S  GS  +  +SL E+HKILHRLLQ
Sbjct: 644 LLTTKSD-QMEPSPLASSLSD-------TNKDSTGSLPGSGSTHGTSLKEKHKILHRLLQ 695

Query: 696 E-GSPSDITTLSVEPDKKDSASTSVSVTGQVQGNSSIKLELDASKKKESKDHQLLRYLLD 754
           +  SP D+  L+ E   KD +  S S         +IK E  + KKKE   + LLRYLLD
Sbjct: 696 DSSSPVDLAKLTAEATGKDLSQESSSTA--PGSEVTIKQEPVSPKKKE---NALLRYLLD 750

Query: 755 KDEKDLRSTPNLSLDDVKVKVEKKE-QMDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQ 813
           KD+     T ++ L ++  K+E+ + + DP +       K   EE+  E   Q  ++LD 
Sbjct: 751 KDD-----TKDIGLPEITPKLERLDSKTDPASNTKLIAMKTEKEEMSFEPGDQPGSELDN 805

Query: 814 FDQLLPTLEKAAQLPGLCETDRMD---GAVTSVTIKSEILPASLQSATARP 861
            +++L  L+  +QLP L    R     G+V    I ++++  + +++   P
Sbjct: 806 LEEILDDLQN-SQLPQLFPDTRPGAPAGSVDKQAIINDLMQLTAENSPVTP 855



 Score =  225 bits (573), Expect = 3e-58
 Identities = 285/1082 (26%), Positives = 449/1082 (41%), Gaps = 214/1082 (19%)

Query: 377  TNSGMSIPRVNPSVNP--SISPAHGVARSSTLPP----------SNSNMVSTRINRQQSS 424
            +++G S    N S+N   ++S  HGV+  S+L            S  NM    +++  S 
Sbjct: 521  SSTGNSHSYTNSSLNALQALSEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSL 580

Query: 425  DLHSSSHSNSSNSQGSFG-----CSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGT 479
            D           S+G+ G     C PG Q   N        SS+ ++    L++S  +  
Sbjct: 581  DSKDCFGLYGEPSEGTTGQAESSCHPGEQKETNDPNLPPAVSSERADGQSRLHDSKGQTK 640

Query: 480  GISLAQFMSPRRQ---VTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNR-SYSN 535
             + L    S + +   + S L+   +    S P + ST  + +       +   + S S 
Sbjct: 641  LLQLLTTKSDQMEPSPLASSLSDTNKDSTGSLPGSGSTHGTSLKEKHKILHRLLQDSSSP 700

Query: 536  IPVTSLQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEM 595
            + +  L     G + S   S+++P         S   +  +P   + K+N    ++L  +
Sbjct: 701  VDLAKLTAEATGKDLSQESSSTAP--------GSEVTIKQEPVSPKKKEN----ALLRYL 748

Query: 596  IQSDNSSSDGKPLDSGLLHNNDRLSDGDSKYSQTSH-KLVQLLTTTAEQQLRHADIDTSC 654
            +  D++       D GL     +L   DSK    S+ KL+ + T   E      D   S 
Sbjct: 749  LDKDDTK------DIGLPEITPKLERLDSKTDPASNTKLIAMKTEKEEMSFEPGDQPGSE 802

Query: 655  KDVLS--CTGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKK 712
             D L        NS        + P + +   ++  I++ L+Q         L+ E    
Sbjct: 803  LDNLEEILDDLQNSQLPQLFPDTRPGAPAGSVDKQAIINDLMQ---------LTAE---- 849

Query: 713  DSASTSVSVTGQVQGNSSIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVK 772
            +S  T V       G     L +  S     +  QL R L ++         NL LD   
Sbjct: 850  NSPVTPV-------GAQKTALRISQSTFNNPRPGQLGRLLPNQ---------NLPLDITL 893

Query: 773  VKVEKKEQMDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQFDQ----------LLPTLE 822
                      P   +      P P  +  +       +L                +P+ E
Sbjct: 894  QSPTGAGPFPPIRNSSPYSVIPQPGMMGNQGMIGNQGNLGNSSTGMIGNSASRPTMPSGE 953

Query: 823  KAAQLPGLCETDRMDGAVTSVTIKSEILPASLQSATARPTSRLNRLPELELEA------- 875
             A Q   +  T     +  +  ++  ++     S   RP+S+  +   L+ +        
Sbjct: 954  WAPQSSAVRVTCAATTSAMNRPVQGGMIRNPAASIPMRPSSQPGQRQTLQSQVMNIGPSE 1013

Query: 876  IDNQFGQPGTGDQ-------IPWTNNTVTAINQSK---SEDQCISSQLDELLCPPTTVEG 925
            ++   G P    Q        PW  + +  I+Q+       Q   S  D+LLCP    E 
Sbjct: 1014 LEMNMGGPQYSQQQAPPNQTAPWPES-ILPIDQASFASQNRQPFGSSPDDLLCPHPAAES 1072

Query: 926  RNDEKALLEQLVSFLSGKDETELAELDRALGIDKLV-QGGGLDVLSERFPPQQATPPLIM 984
             +DE ALL+QL  +L+ ++   L E+DRALGI +LV Q   +D   E+F  Q +   +++
Sbjct: 1073 PSDEGALLDQL--YLALRNFDGLEEIDRALGIPELVSQSQAVD--PEQFSSQDSN--IML 1126

Query: 985  EERPNLYSQPYSSPSPTAN-----LPSPFQGMVRQKPSLGTMPVQVTPPRGAFSPGMGMQ 1039
            E++  ++ Q Y+S +  A      +  P    + Q+PS  T+ +Q  P         G++
Sbjct: 1127 EQKAPVFPQQYASQAQMAQGSYSPMQDPNFHTMGQRPSYATLRMQPRP---------GLR 1177

Query: 1040 PRQTLNRPPAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQFAATAPVGINMRSGMQQQIT 1099
            P   +   P   NQLRLQLQ RLQ QQ     NRQ ++NQ +  + V + +R G    + 
Sbjct: 1178 PTGLVQNQP---NQLRLQLQHRLQAQQ-----NRQPLMNQISNVSNVNLTLRPG----VP 1225

Query: 1100 PQPPLNAQMLAQRQRELYSQQHRQRQLIQQQ----RAMLMRQQSFGNNLPPS----SGLP 1151
             Q P+NAQMLAQRQRE+ +Q  RQRQ+ QQQ    R ++MR Q  G N+ PS    SG+P
Sbjct: 1226 TQAPINAQMLAQRQREILNQHLRQRQMHQQQQVQQRTLMMRGQ--GLNMTPSMVAPSGMP 1283

Query: 1152 VQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLANRNSMVSRGMTG 1211
              M NPR+PQ   QQFP+PPNYG +    P  T      A  P++ L             
Sbjct: 1284 ATMSNPRIPQANAQQFPFPPNYGISQQPDPGFTG-----ATTPQSPL------------- 1325

Query: 1212 NIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPIPPPQSSLLQQT 1271
                     ++P+M     Q P   M+ Q +AN A                         
Sbjct: 1326 ---------MSPRMAHT--QSP---MMQQSQANPA------------------------- 1346

Query: 1272 PPASGYQSP-DMKAWQQGAIGNNNVFSQAVQNQP---TPAQPGVY-NNMSITVSMAGGNT 1326
                 YQ+P D+  W QG +G N++FSQ  Q+ P     A   +Y NNM+I VSMA    
Sbjct: 1347 -----YQAPSDINGWAQGNMGGNSMFSQ--QSPPHFGQQANTSMYSNNMNINVSMATNTG 1399

Query: 1327 NVQNMNPMMAQMQM---SSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLKTEADG 1383
             + +MN M  Q+ M   +S+   G++++ PEQ+NDPALR   L+ NQL   D++K E D 
Sbjct: 1400 GMSSMNQMTGQISMTSVTSVPTSGLSSMGPEQVNDPALRGGNLFPNQLPGMDMIKQEGDT 1459

Query: 1384 TQ 1385
            T+
Sbjct: 1460 TR 1461


>gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens]
          Length = 1424

 Score =  494 bits (1273), Expect = e-139
 Identities = 340/866 (39%), Positives = 504/866 (58%), Gaps = 104/866 (12%)

Query: 1   MSGLGDSSSDPANPDSHKRKGSPCDT----LASSTEKRRREQENKYLEELAELLSANISD 56
           MSGLG++  DP   DS KRK  PCDT    L  S EKRRREQE+KY+EELAEL+SAN+SD
Sbjct: 1   MSGLGENL-DPLASDSRKRK-LPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSD 58

Query: 57  IDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS-TTDDDVQKSDISSSSQGVIEKESLGPL 115
           ID+ +VKPDKC ILK+TV QI+ +K  EQ K+ + DDDVQK+D+SS+ QGVI+K+SLGPL
Sbjct: 59  IDNFNVKPDKCAILKETVRQIRQIK--EQGKTISNDDDVQKADVSSTGQGVIDKDSLGPL 116

Query: 116 LLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPK 175
           LL+ALDGF FVVN +G IVFVSENVT YL Y QE+L+NTSVY+ILH  D  +F+KN LPK
Sbjct: 117 LLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKN-LPK 175

Query: 176 SLVNGVPWPQEATRRNSHTFNCRMLIHPPD---EPGTENQEACQRYEVMQCFTVSQPKSI 232
           S VNGV W  E  R+ SHTFNCRML+  P    E    + E  QRYE MQCF +SQP+++
Sbjct: 176 STVNGVSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAM 235

Query: 233 QEDGEDFQSCLICIARRLPRPPAI--TGVESFMTKQDTTGKIISIDTSSLRAAGRTGWED 290
            E+GED QSC+IC+ARR+        +  ESF+T+ D +GK+++IDT+SLR++ R G+ED
Sbjct: 236 MEEGEDLQSCMICVARRITTGERTFPSNPESFITRHDLSGKVVNIDTNSLRSSMRPGFED 295

Query: 291 LVRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLC-YP 349
           ++R+CI  FF     +    ++ +QE    G A +P YRF L DGT+++A TK KL   P
Sbjct: 296 IIRRCIQRFFSLNDGQSWSQKRHYQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRNP 355

Query: 350 QSPDMQPFIMGIHIIDREHSGLSPQ-DDTNSGMSIPRV--NPSV-NPSISPAHGVARSST 405
            + D   F+   H + RE +G  P  +    G+  P    N SV   S+SP  G+     
Sbjct: 356 VTNDRHGFV-STHFLQREQNGYRPNPNPVGQGIRPPMAGCNSSVGGMSMSPNQGL----Q 410

Query: 406 LPPSNSNMVSTRINRQQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSS 465
           +P S +  ++      Q S       SN ++       +PG  +       Q  +S Q++
Sbjct: 411 MPSSRAYGLADPSTTGQMSGARYGGSSNIAS------LTPGPGM-------QSPSSYQNN 457

Query: 466 NPSLNLNNSPMEGTGISLAQ---FMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMT 522
           N  LN+++ P    G++  Q    +SPR + +      P++ ++ F P ++ + SP+   
Sbjct: 458 NYGLNMSSPPHGSPGLAPNQQNIMISPRNRGS------PKIASHQFSP-VAGVHSPM--- 507

Query: 523 SSACNNNNRSYSNIPVTSLQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAES 582
           +S+ N  N S+S+  +++LQ ++EG   S+  + SSP        NSP+    QP+K  +
Sbjct: 508 ASSGNTGNHSFSSSSLSALQAISEGVGTSLLSTLSSP---GPKLDNSPNMNITQPSKVSN 564

Query: 583 KDNKEIASILNEMIQSDNSSSDGKPLDSGLLHNN--DRLSDGDSKYSQTS---------- 630
           +D+K                 D  P++S +  +N  D LSD +SK S             
Sbjct: 565 QDSKSPLGFY----------CDQNPVESSMCQSNSRDHLSDKESKESSVEGAENQRGPLE 614

Query: 631 ----HKLVQLLTTTAEQQ----LRHADIDTSCKDVLSCTGTSNSASANSSGGSCPSSH-- 680
                KL+QLLT +++ +    L ++ +D+SCK+      + +  S+++SGG   +S+  
Sbjct: 615 SKGHKKLLQLLTCSSDDRGHSSLTNSPLDSSCKESSVSVTSPSGVSSSTSGGVSSTSNMH 674

Query: 681 -SSLTERHKILHRLLQEG-SPSDITTLSVEPDKKDSASTSVSVTGQVQGNSSIKLELDAS 738
            S L E+H+ILH+LLQ G SP+++  ++ E   KD++S +    G V     +K E  + 
Sbjct: 675 GSLLQEKHRILHKLLQNGNSPAEVAKITAEATGKDTSSITSCGDGNV-----VKQEQLSP 729

Query: 739 KKKESKDHQLLRYLLDKDEKDLRSTPNLSLD-DVKVKVEKKE-QMDPCNTNPTPMTKPTP 796
           KKKE  ++ LLRYLLD+D+      P+ +L  +++ +VE  + +M  C ++  P +    
Sbjct: 730 KKKE--NNALLRYLLDRDD------PSDALSKELQPQVEGVDNKMSQCTSSTIPSSSQEK 781

Query: 797 E-EIKLEAQSQFTADLDQFDQLLPTL 821
           + +IK E   + + DLD  D +L  L
Sbjct: 782 DPKIKTETSEEGSGDLDNLDAILGDL 807



 Score =  201 bits (512), Expect = 3e-51
 Identities = 274/1102 (24%), Positives = 442/1102 (40%), Gaps = 254/1102 (23%)

Query: 369  SGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINRQQS----- 423
            + L+P     S  S    N  +N S SP HG   S  L P+  N++ +  NR        
Sbjct: 440  ASLTPGPGMQSPSSYQNNNYGLNMS-SPPHG---SPGLAPNQQNIMISPRNRGSPKIASH 495

Query: 424  -----SDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASS---QSSNPSLNLNNSP 475
                 + +HS   S+ +    SF     S + A  A+++G  +S     S+P   L+NSP
Sbjct: 496  QFSPVAGVHSPMASSGNTGNHSFS---SSSLSALQAISEGVGTSLLSTLSSPGPKLDNSP 552

Query: 476  ----MEGTGISLAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSA------ 525
                 + + +S     SP             M  ++   ++S   S       A      
Sbjct: 553  NMNITQPSKVSNQDSKSPLGFYCDQNPVESSMCQSNSRDHLSDKESKESSVEGAENQRGP 612

Query: 526  --------------CNNNNRSYSN--------------IPVTSLQGMNEGPNNSVGFSAS 557
                          C++++R +S+              + VTS  G++   +  V  +++
Sbjct: 613  LESKGHKKLLQLLTCSSDDRGHSSLTNSPLDSSCKESSVSVTSPSGVSSSTSGGVSSTSN 672

Query: 558  --SPVLRQ--------MSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDNSSSDGKP 607
                +L++        + + NSP+ +    A+A  KD   I S  +  +      S  K 
Sbjct: 673  MHGSLLQEKHRILHKLLQNGNSPAEVAKITAEATGKDTSSITSCGDGNVVKQEQLSPKKK 732

Query: 608  LDSGLLH---NNDRLSDG------------DSKYSQTSHKLV---------QLLTTTAEQ 643
             ++ LL    + D  SD             D+K SQ +   +         ++ T T+E+
Sbjct: 733  ENNALLRYLLDRDDPSDALSKELQPQVEGVDNKMSQCTSSTIPSSSQEKDPKIKTETSEE 792

Query: 644  QLRHAD-IDTSCKDVLSCTGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDI 702
                 D +D    D+ S    +NS S+N S          L  + ++       G  S  
Sbjct: 793  GSGDLDNLDAILGDLTSSDFYNNSISSNGS---------HLGTKQQVFQGTNSLGLKSSQ 843

Query: 703  TTLSVEPDKKDSAS----TSVSVTGQVQGNSSI----KLELDASKKKESKDHQLLRYLLD 754
            +  S+ P    + S     SV  +  V+  S+     K  +     +     +     + 
Sbjct: 844  SVQSIRPPYNRAVSLDSPVSVGSSPPVKNISAFPMLPKQPMLGGNPRMMDSQENYGSSMG 903

Query: 755  KDEKDLRSTPNLSLDDVKVKVEKKEQMDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQF 814
               +++  T   S  D  +   K  +M+P N+N   M +P  +                +
Sbjct: 904  GPNRNVTVTQTPSSGDWGLPNSKAGRMEPMNSNS--MGRPGGD----------------Y 945

Query: 815  DQLLPTLEKAAQLPGLCETDRMDGAVTSVTIKSEILPASLQSATARPTSRLNRLPELELE 874
            +  LP                + G++ ++ ++S  +P +      +      R  E+ + 
Sbjct: 946  NTSLPR-------------PALGGSIPTLPLRSNSIPGARPVLQQQQQMLQMRPGEIPMG 992

Query: 875  AIDNQFGQPGTGDQI-PWTNNTVTA--INQSKSEDQCISSQLDELLCPPTTVEGRNDEKA 931
               N +GQ    +Q+  W +  ++   ++        + + LD+L+ PP+ +EG++DE+A
Sbjct: 993  MGANPYGQAAASNQLGSWPDGMLSMEQVSHGTQNRPLLRNSLDDLVGPPSNLEGQSDERA 1052

Query: 932  LLEQLVSFLSGKDETELAELDRALGIDKLV-QGGGLDVLSERFPPQQATPPLIMEERPNL 990
            LL+QL + LS  D T L E+DRALGI +LV QG  L+   + F  Q+A   ++M+++  L
Sbjct: 1053 LLDQLHTLLSNTDATGLEEIDRALGIPELVNQGQALEPKQDAFQGQEAA--VMMDQKAGL 1110

Query: 991  YSQPYSSPSPTANLPSPFQG---MVRQKPSLGTMPVQVTPPRGAFSPGMGMQPRQTLNRP 1047
            Y Q Y +  P      P QG   +  Q PS  +M  Q+   +G F P  GM PR  + RP
Sbjct: 1111 YGQTYPAQGP------PMQGGFHLQGQSPSFNSMMNQMN-QQGNF-PLQGMHPRANIMRP 1162

Query: 1048 PA-APNQLRLQLQQRLQGQQQLIHQNRQAI-LNQFAATAPVGINMRSGMQQQITPQPP-L 1104
                P QLR+QLQQRLQG QQ ++Q+RQA+ L     TA     MR  MQ Q++ Q   L
Sbjct: 1163 RTNTPKQLRMQLQQRLQG-QQFLNQSRQALELKMENPTAGGAAVMRPMMQPQVSSQQGFL 1221

Query: 1105 NAQMLAQRQRELYS---------------------QQHRQRQLIQQQRAMLMRQQSFGNN 1143
            NAQM+AQR REL S                     QQ +Q+Q  QQQ+    +QQ+   +
Sbjct: 1222 NAQMVAQRSRELLSHHFRQQRVAMMMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTQAFS 1281

Query: 1144 LPP----SSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLA 1199
             PP    S  +   +  P +PQ  PQQFPY PNYG      PA    F ++++ P A ++
Sbjct: 1282 PPPNVTASPSMDGLLAGPTMPQAPPQQFPYQPNYGMGQQPDPA----FGRVSSPPNAMMS 1337

Query: 1200 NRNSMVSRGMTGNIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMP 1259
            +R                G   NP MQ                                 
Sbjct: 1338 SR---------------MGPSQNPMMQH-------------------------------- 1350

Query: 1260 IPPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITV 1319
               PQ+        AS YQS +MK W  G +  N+ FSQ  Q       P VY+   + +
Sbjct: 1351 ---PQA--------ASIYQSSEMKGWPSGNLARNSSFSQ--QQFAHQGNPAVYS--MVHM 1395

Query: 1320 SMAGGNTNVQNMNPM-MAQMQM 1340
            + + G+    NMNPM M+ M M
Sbjct: 1396 NGSSGHMGQMNMNPMPMSGMPM 1417


>gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens]
          Length = 1420

 Score =  494 bits (1273), Expect = e-139
 Identities = 340/866 (39%), Positives = 504/866 (58%), Gaps = 104/866 (12%)

Query: 1   MSGLGDSSSDPANPDSHKRKGSPCDT----LASSTEKRRREQENKYLEELAELLSANISD 56
           MSGLG++  DP   DS KRK  PCDT    L  S EKRRREQE+KY+EELAEL+SAN+SD
Sbjct: 1   MSGLGENL-DPLASDSRKRK-LPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSD 58

Query: 57  IDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS-TTDDDVQKSDISSSSQGVIEKESLGPL 115
           ID+ +VKPDKC ILK+TV QI+ +K  EQ K+ + DDDVQK+D+SS+ QGVI+K+SLGPL
Sbjct: 59  IDNFNVKPDKCAILKETVRQIRQIK--EQGKTISNDDDVQKADVSSTGQGVIDKDSLGPL 116

Query: 116 LLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPK 175
           LL+ALDGF FVVN +G IVFVSENVT YL Y QE+L+NTSVY+ILH  D  +F+KN LPK
Sbjct: 117 LLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKN-LPK 175

Query: 176 SLVNGVPWPQEATRRNSHTFNCRMLIHPPD---EPGTENQEACQRYEVMQCFTVSQPKSI 232
           S VNGV W  E  R+ SHTFNCRML+  P    E    + E  QRYE MQCF +SQP+++
Sbjct: 176 STVNGVSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAM 235

Query: 233 QEDGEDFQSCLICIARRLPRPPAI--TGVESFMTKQDTTGKIISIDTSSLRAAGRTGWED 290
            E+GED QSC+IC+ARR+        +  ESF+T+ D +GK+++IDT+SLR++ R G+ED
Sbjct: 236 MEEGEDLQSCMICVARRITTGERTFPSNPESFITRHDLSGKVVNIDTNSLRSSMRPGFED 295

Query: 291 LVRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLC-YP 349
           ++R+CI  FF     +    ++ +QE    G A +P YRF L DGT+++A TK KL   P
Sbjct: 296 IIRRCIQRFFSLNDGQSWSQKRHYQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRNP 355

Query: 350 QSPDMQPFIMGIHIIDREHSGLSPQ-DDTNSGMSIPRV--NPSV-NPSISPAHGVARSST 405
            + D   F+   H + RE +G  P  +    G+  P    N SV   S+SP  G+     
Sbjct: 356 VTNDRHGFV-STHFLQREQNGYRPNPNPVGQGIRPPMAGCNSSVGGMSMSPNQGL----Q 410

Query: 406 LPPSNSNMVSTRINRQQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSS 465
           +P S +  ++      Q S       SN ++       +PG  +       Q  +S Q++
Sbjct: 411 MPSSRAYGLADPSTTGQMSGARYGGSSNIAS------LTPGPGM-------QSPSSYQNN 457

Query: 466 NPSLNLNNSPMEGTGISLAQ---FMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMT 522
           N  LN+++ P    G++  Q    +SPR + +      P++ ++ F P ++ + SP+   
Sbjct: 458 NYGLNMSSPPHGSPGLAPNQQNIMISPRNRGS------PKIASHQFSP-VAGVHSPM--- 507

Query: 523 SSACNNNNRSYSNIPVTSLQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAES 582
           +S+ N  N S+S+  +++LQ ++EG   S+  + SSP        NSP+    QP+K  +
Sbjct: 508 ASSGNTGNHSFSSSSLSALQAISEGVGTSLLSTLSSP---GPKLDNSPNMNITQPSKVSN 564

Query: 583 KDNKEIASILNEMIQSDNSSSDGKPLDSGLLHNN--DRLSDGDSKYSQTS---------- 630
           +D+K                 D  P++S +  +N  D LSD +SK S             
Sbjct: 565 QDSKSPLGFY----------CDQNPVESSMCQSNSRDHLSDKESKESSVEGAENQRGPLE 614

Query: 631 ----HKLVQLLTTTAEQQ----LRHADIDTSCKDVLSCTGTSNSASANSSGGSCPSSH-- 680
                KL+QLLT +++ +    L ++ +D+SCK+      + +  S+++SGG   +S+  
Sbjct: 615 SKGHKKLLQLLTCSSDDRGHSSLTNSPLDSSCKESSVSVTSPSGVSSSTSGGVSSTSNMH 674

Query: 681 -SSLTERHKILHRLLQEG-SPSDITTLSVEPDKKDSASTSVSVTGQVQGNSSIKLELDAS 738
            S L E+H+ILH+LLQ G SP+++  ++ E   KD++S +    G V     +K E  + 
Sbjct: 675 GSLLQEKHRILHKLLQNGNSPAEVAKITAEATGKDTSSITSCGDGNV-----VKQEQLSP 729

Query: 739 KKKESKDHQLLRYLLDKDEKDLRSTPNLSLD-DVKVKVEKKE-QMDPCNTNPTPMTKPTP 796
           KKKE  ++ LLRYLLD+D+      P+ +L  +++ +VE  + +M  C ++  P +    
Sbjct: 730 KKKE--NNALLRYLLDRDD------PSDALSKELQPQVEGVDNKMSQCTSSTIPSSSQEK 781

Query: 797 E-EIKLEAQSQFTADLDQFDQLLPTL 821
           + +IK E   + + DLD  D +L  L
Sbjct: 782 DPKIKTETSEEGSGDLDNLDAILGDL 807



 Score =  198 bits (504), Expect = 3e-50
 Identities = 274/1101 (24%), Positives = 440/1101 (39%), Gaps = 256/1101 (23%)

Query: 369  SGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINRQQS----- 423
            + L+P     S  S    N  +N S SP HG   S  L P+  N++ +  NR        
Sbjct: 440  ASLTPGPGMQSPSSYQNNNYGLNMS-SPPHG---SPGLAPNQQNIMISPRNRGSPKIASH 495

Query: 424  -----SDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASS---QSSNPSLNLNNSP 475
                 + +HS   S+ +    SF     S + A  A+++G  +S     S+P   L+NSP
Sbjct: 496  QFSPVAGVHSPMASSGNTGNHSFS---SSSLSALQAISEGVGTSLLSTLSSPGPKLDNSP 552

Query: 476  ----MEGTGISLAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSA------ 525
                 + + +S     SP             M  ++   ++S   S       A      
Sbjct: 553  NMNITQPSKVSNQDSKSPLGFYCDQNPVESSMCQSNSRDHLSDKESKESSVEGAENQRGP 612

Query: 526  --------------CNNNNRSYSN--------------IPVTSLQGMNEGPNNSVGFSAS 557
                          C++++R +S+              + VTS  G++   +  V  +++
Sbjct: 613  LESKGHKKLLQLLTCSSDDRGHSSLTNSPLDSSCKESSVSVTSPSGVSSSTSGGVSSTSN 672

Query: 558  --SPVLRQ--------MSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDNSSSDGKP 607
                +L++        + + NSP+ +    A+A  KD   I S  +  +      S  K 
Sbjct: 673  MHGSLLQEKHRILHKLLQNGNSPAEVAKITAEATGKDTSSITSCGDGNVVKQEQLSPKKK 732

Query: 608  LDSGLLH---NNDRLSDG------------DSKYSQTSHKLV---------QLLTTTAEQ 643
             ++ LL    + D  SD             D+K SQ +   +         ++ T T+E+
Sbjct: 733  ENNALLRYLLDRDDPSDALSKELQPQVEGVDNKMSQCTSSTIPSSSQEKDPKIKTETSEE 792

Query: 644  QLRHAD-IDTSCKDVLSCTGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDI 702
                 D +D    D+ S    +NS S+N S          L  + ++       G  S  
Sbjct: 793  GSGDLDNLDAILGDLTSSDFYNNSISSNGS---------HLGTKQQVFQGTNSLGLKSSQ 843

Query: 703  TTLSVEPDKKDSAS----TSVSVTGQVQGNSSI----KLELDASKKKESKDHQLLRYLLD 754
            +  S+ P    + S     SV  +  V+  S+     K  +     +     +     + 
Sbjct: 844  SVQSIRPPYNRAVSLDSPVSVGSSPPVKNISAFPMLPKQPMLGGNPRMMDSQENYGSSMG 903

Query: 755  KDEKDLRSTPNLSLDDVKVKVEKKEQMDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQF 814
               +++  T   S  D  +   K  +M+P N+N   M +P  +                +
Sbjct: 904  GPNRNVTVTQTPSSGDWGLPNSKAGRMEPMNSNS--MGRPGGD----------------Y 945

Query: 815  DQLLPTLEKAAQLPGLCETDRMDGAVTSVTIKSEILPASLQSATARPTSRLNRLPELELE 874
            +  LP                + G++ ++ ++S  +P +      +      R  E+ + 
Sbjct: 946  NTSLPR-------------PALGGSIPTLPLRSNSIPGARPVLQQQQQMLQMRPGEIPMG 992

Query: 875  AIDNQFGQPGTGDQI-PWTNNTVTA--INQSKSEDQCISSQLDELLCPPTTVEGRNDEKA 931
               N +GQ    +Q+  W +  ++   ++        + + LD+L+ PP+ +EG++DE+A
Sbjct: 993  MGANPYGQAAASNQLGSWPDGMLSMEQVSHGTQNRPLLRNSLDDLVGPPSNLEGQSDERA 1052

Query: 932  LLEQLVSFLSGKDETELAELDRALGIDKLV-QGGGLDVLSERFPPQQATPPLIMEERPNL 990
            LL+QL + LS  D T L E+DRALGI +LV QG  L+   + F  Q+A   ++M+++  L
Sbjct: 1053 LLDQLHTLLSNTDATGLEEIDRALGIPELVNQGQALEPKQDAFQGQEAA--VMMDQKAGL 1110

Query: 991  YSQPYSSPSPTANLPSPFQG---MVRQKPSLGTMPVQVTPPRGAFSPGMGMQPRQTLNRP 1047
            Y Q Y +  P      P QG   +  Q PS  +M  Q+   +G F P  GM PR  + RP
Sbjct: 1111 YGQTYPAQGP------PMQGGFHLQGQSPSFNSMMNQMN-QQGNF-PLQGMHPRANIMRP 1162

Query: 1048 PA-APNQLRLQLQQRLQGQQQLIHQNRQAI-LNQFAATAPVGINMRSGMQQQITPQPPLN 1105
                P QLR+QLQQRLQG QQ ++Q+RQA+ L     TA     MR  MQ Q   Q  LN
Sbjct: 1163 RTNTPKQLRMQLQQRLQG-QQFLNQSRQALELKMENPTAGGAAVMRPMMQPQ---QGFLN 1218

Query: 1106 AQMLAQRQRELYS---------------------QQHRQRQLIQQQRAMLMRQQSFGNNL 1144
            AQM+AQR REL S                     QQ +Q+Q  QQQ+    +QQ+   + 
Sbjct: 1219 AQMVAQRSRELLSHHFRQQRVAMMMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTQAFSP 1278

Query: 1145 PP----SSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLAN 1200
            PP    S  +   +  P +PQ  PQQFPY PNYG      PA    F ++++ P A +++
Sbjct: 1279 PPNVTASPSMDGLLAGPTMPQAPPQQFPYQPNYGMGQQPDPA----FGRVSSPPNAMMSS 1334

Query: 1201 RNSMVSRGMTGNIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPI 1260
            R                G   NP MQ                                  
Sbjct: 1335 R---------------MGPSQNPMMQH--------------------------------- 1346

Query: 1261 PPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVS 1320
              PQ+        AS YQS +MK W  G +  N+ FSQ  Q       P VY+   + ++
Sbjct: 1347 --PQA--------ASIYQSSEMKGWPSGNLARNSSFSQ--QQFAHQGNPAVYS--MVHMN 1392

Query: 1321 MAGGNTNVQNMNPM-MAQMQM 1340
             + G+    NMNPM M+ M M
Sbjct: 1393 GSSGHMGQMNMNPMPMSGMPM 1413


>gi|21614542 single-minded homolog 1 [Homo sapiens]
          Length = 766

 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 102/425 (24%), Positives = 183/425 (43%), Gaps = 59/425 (13%)

Query: 28  ASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEK 87
           + +  + RRE+EN    ELA+LL        +++ + DK  I++ T   +++       +
Sbjct: 5   SKNAARTRREKENSEFYELAKLLPLP----SAITSQLDKASIIRLTTSYLKM-------R 53

Query: 88  STTDDDVQKSDISSSSQGVIEK--ESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLG 145
               + + ++   SS    ++     LG  LL+ LDGF FVV  +G+I+++SE  + +LG
Sbjct: 54  VVFPEGLGEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLG 113

Query: 146 YNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPD 205
            +Q EL   S+Y  +H  DH E    L      +   + QE     S     + ++   +
Sbjct: 114 LSQVELTGNSIYEYIHPADHDEMTAVLTAHQPYHS-HFVQEYEIERSFFLRMKCVLAKRN 172

Query: 206 EPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQSC-----LICIARRLPRPPAITGVE 260
              T     C  Y+V+ C    + +    D   F  C     L+ +   LP P A+T ++
Sbjct: 173 AGLT-----CGGYKVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLP-PSAVTEIK 226

Query: 261 ----SFMTKQDTTGKIISIDTSSLRAAGRTGWE--DLVRKCIYAFFQPQGREPSYARQLF 314
                FM +     K+I +D+   R A  TG+E  DL+ K +Y      G +  + R   
Sbjct: 227 LHSNMFMFRASLDMKLIFLDS---RVAELTGYEPQDLIEKTLY--HHVHGCDTFHLRCAH 281

Query: 315 QEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMGIHII--DREHSGLS 372
             ++ +G  ++  YRF+   G  +   +   + +         I+ ++ +  D E+ GL 
Sbjct: 282 HLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQ 341

Query: 373 PQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINRQQSSDLHSSSHS 432
                   +S+ +++ S      PA     SST  P+ ++      NR+ +    SSS S
Sbjct: 342 --------LSLDQISAS-----KPAFSYTSSST--PTMTD------NRKGAKSRLSSSKS 380

Query: 433 NSSNS 437
            S  S
Sbjct: 381 KSRTS 385


>gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Homo
           sapiens]
          Length = 717

 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 155/650 (23%), Positives = 250/650 (38%), Gaps = 125/650 (19%)

Query: 2   SGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLS 61
           SG+     D   P    R+        S  E+RRR +  +Y+ EL+++    +    +L+
Sbjct: 48  SGMDFDDEDGEGPSKFSRENH------SEIERRRRNKMTQYITELSDM----VPTCSALA 97

Query: 62  VKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEALD 121
            KPDK  IL+  V     MK M    + + D   K          + ++ L  L+LEA D
Sbjct: 98  RKPDKLTILRMAVSH---MKSMRGTGNKSTDGAYKPSF-------LTEQELKHLILEAAD 147

Query: 122 GFFFVVNCE-GRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPK----- 175
           GF FVV  E GR+++VS++VT  L   Q E   +++Y  +H  D  +  + L        
Sbjct: 148 GFLFVVAAETGRVIYVSDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMT 207

Query: 176 ----SLVNGV--PWPQEATRR----NSHTFNCRM------LIHPPDEPGTEN-------- 211
                L  G      Q+++ R    +  +F CRM      L H P    T          
Sbjct: 208 GRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGL 267

Query: 212 ---QEACQRYEVMQC---------FTVSQPKSIQEDGEDFQSCLICIAR-RLPRPPAITG 258
              +E   +Y V+ C           ++ P+   + G+  + CL+ I R ++   P    
Sbjct: 268 GPVKEGEAQYAVVHCTGYIKAWPPAGMTIPEEDADVGQGSKYCLVAIGRLQVTSSPVCMD 327

Query: 259 VE------SFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQ 312
           +        F+++ ++ G I  +D   +   G    +DL+ K I  F  P+  + S+ R+
Sbjct: 328 MNGMSVPTEFLSRHNSDGIITFVDPRCISVIGYQP-QDLLGKDILEFCHPE--DQSHLRE 384

Query: 313 LFQEVM-TRGTASSPSYRF-ILNDGTMLSAHTKCKLCYPQSPDMQPFI-----------M 359
            FQ+V+  +G   S  YRF   N   ML   +      P S +++  I            
Sbjct: 385 SFQQVVKLKGQVLSVMYRFRTKNREWMLIRTSSFTFQNPYSDEIEYIICTNTNVKQLQQQ 444

Query: 360 GIHIIDREHSGLSPQDDTNSGMSIPRVNPSVN---PSISPAHGVARSSTLPPSNSNMVST 416
              +   +  GLS  D   S + +P +   V+    S+  A  +      P         
Sbjct: 445 QAELEVHQRDGLSSYD--LSQVPVPNLPAGVHEAGKSVEKADAIFSQERDPRFAEMFAGI 502

Query: 417 RINRQQSSDLHSSSHSNSSNSQGS------FGCSPGSQIVANVALNQGQASSQS----SN 466
             + ++     S++ +    SQGS       G +  S +V    +N  Q+SS +    S 
Sbjct: 503 SASEKKMMSSASAAGTQQIYSQGSPFPSGHSGKAFSSSVVHVPGVNDIQSSSSTGQNMSQ 562

Query: 467 PSLNLNNSPMEGTGISLAQFMSPRRQVTSGLATRPRMPNNSFPPNIS-TLSSPVGM-TSS 524
            S  LN S +  TG                  +RP  P    P   S T SSP G+ TS 
Sbjct: 563 ISRQLNQSQVAWTG------------------SRPPFPGQQIPSQSSKTQSSPFGIGTSH 604

Query: 525 ACNNNNRSYSNI--PVTSLQGMN---EGPNNSVGFSASSPVLRQMSSQNS 569
               +  SYS +  P TS    N      N + GF+ S     Q   + S
Sbjct: 605 TYPADPSSYSPLSSPATSSPSGNAYSSLANRTPGFAESGQSSGQFQGRPS 654


>gi|4758010 clock [Homo sapiens]
          Length = 846

 Score = 84.3 bits (207), Expect = 7e-16
 Identities = 56/185 (30%), Positives = 96/185 (51%), Gaps = 19/185 (10%)

Query: 29  SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS 88
           + +EK+RR+Q N  ++EL  +L  N         K DK  +L+K++D ++  K +  +  
Sbjct: 40  NKSEKKRRDQFNVLIKELGSMLPGNAR-------KMDKSTVLQKSIDFLRKHKEITAQSD 92

Query: 89  TTD--DDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGY 146
            ++   D + + +S+        E    L+LEALDGFF  +  +G I++VSE+VTS L +
Sbjct: 93  ASEIRQDWKPTFLSN--------EEFTQLMLEALDGFFLAIMTDGSIIYVSESVTSLLEH 144

Query: 147 NQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRML--IHPP 204
              +L++ S+++ +  G+H+E  K L    L +    P+    +N   F C ML     P
Sbjct: 145 LPSDLVDQSIFNFIPEGEHSEVYKILSTHLLESDSLTPEYLKSKNQLEFCCHMLRGTIDP 204

Query: 205 DEPGT 209
            EP T
Sbjct: 205 KEPST 209


>gi|4827004 single-minded homolog 2 long isoform [Homo sapiens]
          Length = 667

 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 82/319 (25%), Positives = 142/319 (44%), Gaps = 32/319 (10%)

Query: 28  ASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEK 87
           + +  K RRE+EN    ELA+LL        +++ + DK  I++ T   +++     +  
Sbjct: 5   SKNAAKTRREKENGEFYELAKLLPLP----SAITSQLDKASIIRLTTSYLKMRAVFPEGL 60

Query: 88  STTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYN 147
               D   +   +    GV ++  LG  LL+ LDGF FVV  +G+I+++SE  + +LG +
Sbjct: 61  G---DAWGQPSRAGPLDGVAKE--LGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLS 115

Query: 148 QEELMNTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPDEP 207
           Q EL   S+Y  +H  DH E    L     ++     QE     S     + ++   +  
Sbjct: 116 QVELTGNSIYEYIHPSDHDEMTAVLTAHQPLHH-HLLQEYEIERSFFLRMKCVLAKRNAG 174

Query: 208 GTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQSC-----LICIARRLPRPPAITGVE-- 260
            T     C  Y+V+ C    + +    D   + SC     L+ + + LP P AIT ++  
Sbjct: 175 LT-----CSGYKVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLP-PSAITEIKLY 228

Query: 261 --SFMTKQDTTGKIISIDTSSLRAAGRTGWE--DLVRKCIYAFFQPQGREPSYARQLFQE 316
              FM +     K+I +D+   R    TG+E  DL+ K +Y      G +  + R     
Sbjct: 229 SNMFMFRASLDLKLIFLDS---RVTEVTGYEPQDLIEKTLY--HHVHGCDVFHLRYAHHL 283

Query: 317 VMTRGTASSPSYRFILNDG 335
           ++ +G  ++  YR +   G
Sbjct: 284 LLVKGQVTTKYYRLLSKRG 302


>gi|194239684 single-minded homolog 2 short isoform [Homo sapiens]
          Length = 570

 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 82/319 (25%), Positives = 142/319 (44%), Gaps = 32/319 (10%)

Query: 28  ASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEK 87
           + +  K RRE+EN    ELA+LL        +++ + DK  I++ T   +++     +  
Sbjct: 5   SKNAAKTRREKENGEFYELAKLLPLP----SAITSQLDKASIIRLTTSYLKMRAVFPEGL 60

Query: 88  STTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYN 147
               D   +   +    GV ++  LG  LL+ LDGF FVV  +G+I+++SE  + +LG +
Sbjct: 61  G---DAWGQPSRAGPLDGVAKE--LGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLS 115

Query: 148 QEELMNTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPDEP 207
           Q EL   S+Y  +H  DH E    L     ++     QE     S     + ++   +  
Sbjct: 116 QVELTGNSIYEYIHPSDHDEMTAVLTAHQPLHH-HLLQEYEIERSFFLRMKCVLAKRNAG 174

Query: 208 GTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQSC-----LICIARRLPRPPAITGVE-- 260
            T     C  Y+V+ C    + +    D   + SC     L+ + + LP P AIT ++  
Sbjct: 175 LT-----CSGYKVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLP-PSAITEIKLY 228

Query: 261 --SFMTKQDTTGKIISIDTSSLRAAGRTGWE--DLVRKCIYAFFQPQGREPSYARQLFQE 316
              FM +     K+I +D+   R    TG+E  DL+ K +Y      G +  + R     
Sbjct: 229 SNMFMFRASLDLKLIFLDS---RVTEVTGYEPQDLIEKTLY--HHVHGCDVFHLRYAHHL 283

Query: 317 VMTRGTASSPSYRFILNDG 335
           ++ +G  ++  YR +   G
Sbjct: 284 LLVKGQVTTKYYRLLSKRG 302


>gi|71852582 aryl hydrocarbon receptor nuclear translocator-like
           isoform b [Homo sapiens]
          Length = 582

 Score = 81.3 bits (199), Expect = 6e-15
 Identities = 88/360 (24%), Positives = 148/360 (41%), Gaps = 64/360 (17%)

Query: 29  SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS 88
           S  EKRRR++ N +++ELA L+                C  + + +D++ +++   Q   
Sbjct: 35  SQIEKRRRDKMNSFIDELASLVPT--------------CNAMSRKLDKLTVLRMAVQHMK 80

Query: 89  TTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCE-GRIVFVSENVTSYLGYN 147
           T          ++     +  + L  L+L A DGF FVV C+ G+I+FVSE+V   L Y+
Sbjct: 81  TLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYS 140

Query: 148 QEELMNTSVYSILHVGDHAEFVKNLLPKS-------LVNG----------VPWPQEATRR 190
           Q +L+  S++  LH  D A+ VK  L  S       L++            P P      
Sbjct: 141 QNDLIGQSLFDYLHPKDIAK-VKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSG 199

Query: 191 NSHTFNCRMLIHPP-------DEPGT-----ENQEACQRYEVMQCFTVSQPK-SIQEDGE 237
              +F CRM  + P       D P T     + +  C  +      +    K  + ED E
Sbjct: 200 ARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNE 259

Query: 238 DFQ-----SCLICIARR----LPRPP----AITGVESFMTKQDTTGKIISIDTSSLRAAG 284
                   SCL+ I R     +P+P      +  +E ++++    GK + +D  +     
Sbjct: 260 PDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSME-YVSRHAIDGKFVFVDQRATAILA 318

Query: 285 RTGWEDLVRKCIYAFFQPQ-GREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTK 343
               E L   C   F Q   G      RQ+ Q   TR   ++  Y+F + DG+ ++  ++
Sbjct: 319 YLPQELLGTSCYEYFHQDDIGHLAECHRQVLQ---TREKITTNCYKFKIKDGSFITLRSR 375


>gi|71852580 aryl hydrocarbon receptor nuclear translocator-like
           isoform a [Homo sapiens]
          Length = 625

 Score = 81.3 bits (199), Expect = 6e-15
 Identities = 88/360 (24%), Positives = 148/360 (41%), Gaps = 64/360 (17%)

Query: 29  SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS 88
           S  EKRRR++ N +++ELA L+                C  + + +D++ +++   Q   
Sbjct: 78  SQIEKRRRDKMNSFIDELASLVPT--------------CNAMSRKLDKLTVLRMAVQHMK 123

Query: 89  TTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCE-GRIVFVSENVTSYLGYN 147
           T          ++     +  + L  L+L A DGF FVV C+ G+I+FVSE+V   L Y+
Sbjct: 124 TLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYS 183

Query: 148 QEELMNTSVYSILHVGDHAEFVKNLLPKS-------LVNG----------VPWPQEATRR 190
           Q +L+  S++  LH  D A+ VK  L  S       L++            P P      
Sbjct: 184 QNDLIGQSLFDYLHPKDIAK-VKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSG 242

Query: 191 NSHTFNCRMLIHPP-------DEPGT-----ENQEACQRYEVMQCFTVSQPK-SIQEDGE 237
              +F CRM  + P       D P T     + +  C  +      +    K  + ED E
Sbjct: 243 ARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNE 302

Query: 238 DFQ-----SCLICIARR----LPRPP----AITGVESFMTKQDTTGKIISIDTSSLRAAG 284
                   SCL+ I R     +P+P      +  +E ++++    GK + +D  +     
Sbjct: 303 PDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSME-YVSRHAIDGKFVFVDQRATAILA 361

Query: 285 RTGWEDLVRKCIYAFFQPQ-GREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTK 343
               E L   C   F Q   G      RQ+ Q   TR   ++  Y+F + DG+ ++  ++
Sbjct: 362 YLPQELLGTSCYEYFHQDDIGHLAECHRQVLQ---TREKITTNCYKFKIKDGSFITLRSR 418


>gi|42716311 aryl hydrocarbon receptor nuclear translocator-like
           isoform a [Homo sapiens]
          Length = 625

 Score = 81.3 bits (199), Expect = 6e-15
 Identities = 88/360 (24%), Positives = 148/360 (41%), Gaps = 64/360 (17%)

Query: 29  SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS 88
           S  EKRRR++ N +++ELA L+                C  + + +D++ +++   Q   
Sbjct: 78  SQIEKRRRDKMNSFIDELASLVPT--------------CNAMSRKLDKLTVLRMAVQHMK 123

Query: 89  TTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCE-GRIVFVSENVTSYLGYN 147
           T          ++     +  + L  L+L A DGF FVV C+ G+I+FVSE+V   L Y+
Sbjct: 124 TLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYS 183

Query: 148 QEELMNTSVYSILHVGDHAEFVKNLLPKS-------LVNG----------VPWPQEATRR 190
           Q +L+  S++  LH  D A+ VK  L  S       L++            P P      
Sbjct: 184 QNDLIGQSLFDYLHPKDIAK-VKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSG 242

Query: 191 NSHTFNCRMLIHPP-------DEPGT-----ENQEACQRYEVMQCFTVSQPK-SIQEDGE 237
              +F CRM  + P       D P T     + +  C  +      +    K  + ED E
Sbjct: 243 ARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNE 302

Query: 238 DFQ-----SCLICIARR----LPRPP----AITGVESFMTKQDTTGKIISIDTSSLRAAG 284
                   SCL+ I R     +P+P      +  +E ++++    GK + +D  +     
Sbjct: 303 PDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSME-YVSRHAIDGKFVFVDQRATAILA 361

Query: 285 RTGWEDLVRKCIYAFFQPQ-GREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTK 343
               E L   C   F Q   G      RQ+ Q   TR   ++  Y+F + DG+ ++  ++
Sbjct: 362 YLPQELLGTSCYEYFHQDDIGHLAECHRQVLQ---TREKITTNCYKFKIKDGSFITLRSR 418


>gi|22027471 neuronal PAS domain protein 2 [Homo sapiens]
          Length = 824

 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 83/354 (23%), Positives = 145/354 (40%), Gaps = 36/354 (10%)

Query: 29  SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS 88
           + +EK+RR+Q N  ++EL+ +L  N         K DK  +L+K +  +Q  K  E    
Sbjct: 15  NKSEKKRRDQFNVLIKELSSMLPGNTR-------KMDKTTVLEKVIGFLQ--KHNEVSAQ 65

Query: 89  TTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQ 148
           T   D+Q+    S     +  E    L+LEALDGF   V  +G I++VS+++T  LG+  
Sbjct: 66  TEICDIQQDWKPS----FLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPLLGHLP 121

Query: 149 EELMNTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRML---IHPPD 205
            ++M+ ++ + L   +H+E  K L    LV   P P+     +   F C +L   ++P +
Sbjct: 122 SDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLLRGSLNPKE 181

Query: 206 EPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQSCLICIAR--------RLPRPPAI- 256
            P  E  +    +       V  P     D    + C + + +        RL  P  + 
Sbjct: 182 FPTYEYIKFVGNFRSYN--NVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLATPQFLK 239

Query: 257 ------TGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYA 310
                   +E F ++     K + +D  +    G   +E ++    Y ++     E    
Sbjct: 240 EMCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFE-VLGTSGYDYYHIDDLE--LL 296

Query: 311 RQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMGIHII 364
            +  Q +M  G   S  YRF+      +   T   + Y Q      FI+  H +
Sbjct: 297 ARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSV 350


>gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2
           [Homo sapiens]
          Length = 735

 Score = 74.3 bits (181), Expect = 8e-13
 Identities = 80/357 (22%), Positives = 147/357 (41%), Gaps = 41/357 (11%)

Query: 1   MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSL 60
           M G G  ++D     S +RK    D   S     RR +E++   ELA  L        ++
Sbjct: 1   MEGAG-GANDKKKISSERRKEKSRDAARS-----RRSKESEVFYELAHQLPLP----HNV 50

Query: 61  SVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEAL 120
           S   DK  +++ T+  +++ K ++      +DD+              K  +    L+AL
Sbjct: 51  SSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDM--------------KAQMNCFYLKAL 96

Query: 121 DGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNG 180
           DGF  V+  +G ++++S+NV  Y+G  Q EL   SV+   H  DH E  + L  +   NG
Sbjct: 97  DGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHR---NG 153

Query: 181 VPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQC---FTVSQPKSIQED-- 235
           +   +   +    +F  RM         T N ++   ++V+ C     V    S Q    
Sbjct: 154 LV-KKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSA-TWKVLHCTGHIHVYDTNSNQPQCG 211

Query: 236 -GEDFQSCLICIARRLPRPPAI---TGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDL 291
             +   +CL+ I   +P P  I      ++F+++     K    D       G    E+L
Sbjct: 212 YKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEP-EEL 270

Query: 292 VRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCY 348
           + + IY ++     +  +  +   ++ T+G  ++  YR +   G  +   T+  + Y
Sbjct: 271 LGRSIYEYY--HALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIY 325


>gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1
           [Homo sapiens]
          Length = 826

 Score = 74.3 bits (181), Expect = 8e-13
 Identities = 80/357 (22%), Positives = 147/357 (41%), Gaps = 41/357 (11%)

Query: 1   MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSL 60
           M G G  ++D     S +RK    D   S     RR +E++   ELA  L        ++
Sbjct: 1   MEGAG-GANDKKKISSERRKEKSRDAARS-----RRSKESEVFYELAHQLPLP----HNV 50

Query: 61  SVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEAL 120
           S   DK  +++ T+  +++ K ++      +DD+              K  +    L+AL
Sbjct: 51  SSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDM--------------KAQMNCFYLKAL 96

Query: 121 DGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNG 180
           DGF  V+  +G ++++S+NV  Y+G  Q EL   SV+   H  DH E  + L  +   NG
Sbjct: 97  DGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHR---NG 153

Query: 181 VPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQC---FTVSQPKSIQED-- 235
           +   +   +    +F  RM         T N ++   ++V+ C     V    S Q    
Sbjct: 154 LV-KKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSA-TWKVLHCTGHIHVYDTNSNQPQCG 211

Query: 236 -GEDFQSCLICIARRLPRPPAI---TGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDL 291
             +   +CL+ I   +P P  I      ++F+++     K    D       G    E+L
Sbjct: 212 YKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEP-EEL 270

Query: 292 VRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCY 348
           + + IY ++     +  +  +   ++ T+G  ++  YR +   G  +   T+  + Y
Sbjct: 271 LGRSIYEYY--HALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIY 325


>gi|30795242 aryl hydrocarbon receptor nuclear translocator isoform
           3 [Homo sapiens]
          Length = 774

 Score = 74.3 bits (181), Expect = 8e-13
 Identities = 96/421 (22%), Positives = 172/421 (40%), Gaps = 68/421 (16%)

Query: 29  SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS 88
           S  E+RRR +   Y+ EL+++    +    +L+ KPDK  IL+  V     MK +    +
Sbjct: 80  SEIERRRRNKMTAYITELSDM----VPTCSALARKPDKLTILRMAVSH---MKSLRGTGN 132

Query: 89  TTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCE-GRIVFVSENVTSYLGYN 147
           T+ D   K          +  + L  L+LEA DGF F+V+CE GR+V+VS++VT  L   
Sbjct: 133 TSTDGSYKPSF-------LTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQP 185

Query: 148 QEELMNTSVYSILHVGD------HAEFVKNLLPKSLVN---------GVPWPQEATRRNS 192
           Q E   +++Y  +H  D           +N L   +++         G          + 
Sbjct: 186 QSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSR 245

Query: 193 HTFNCRMLIHPPD-EPGTENQEACQR----------------YEVMQC---------FTV 226
            +F CRM       +P + N+ +  R                + V+ C           V
Sbjct: 246 RSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGV 305

Query: 227 SQPKSIQEDGEDFQSCLICIAR-RLPRPPAITGVES------FMTKQDTTGKIISIDTSS 279
           S P    E G+  + CL+ I R ++   P  T + +      F+++ +  G    +D   
Sbjct: 306 SLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRC 365

Query: 280 LRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVM-TRGTASSPSYRFILNDGTML 338
           +   G    ++L+ K I  F  P+ ++    R  FQ+V+  +G   S  +RF   +   L
Sbjct: 366 VATVGYQP-QELLGKNIVEFCHPEDQQ--LLRDSFQQVVKLKGQVLSVMFRFRSKNQEWL 422

Query: 339 SAHTKCKLCYPQSPDMQPFIMGIHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAH 398
              T          D   +I+  +  + ++S   P+   ++ +  P++ P+ N  +    
Sbjct: 423 WMRTSSFTFQNPYSDEIEYIICTN-TNVKNSSQEPRPTLSNTIQRPQLGPTANLPLEMGS 481

Query: 399 G 399
           G
Sbjct: 482 G 482



 Score = 36.2 bits (82), Expect = 0.23
 Identities = 70/299 (23%), Positives = 98/299 (32%), Gaps = 42/299 (14%)

Query: 1050 APNQLRLQLQ-QRLQGQQQLIHQNRQAILNQFAATAPVGINMRSGMQQQITPQPPLNAQM 1108
            AP Q + Q +   + G+  L   N   ++     T P          + +     L AQ 
Sbjct: 485  APRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEH-------SKPLEKSDGLFAQD 537

Query: 1109 LAQRQRELYSQQHRQRQLIQQQRAMLMRQQSF--GNNLPPS---------SGL--PVQMG 1155
               R  E+Y   +  +        +   QQ F  GN  PP+         SGL  PV + 
Sbjct: 538  RDPRFSEIYHNINADQSKGISSSTVPATQQLFSQGNTFPPTPRPAENFRNSGLAPPVTIV 597

Query: 1156 NPRLPQG---APQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLANRNSMVSRGMTGN 1212
             P    G   A       P  G  P   P + S FS      +A+   R S         
Sbjct: 598  QPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQATAKTRTS--------- 648

Query: 1213 IGGQFGTG-INPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPIPPPQSSLLQQT 1271
               QFG G        +    PGA     G A +    + GS+  P      Q++   QT
Sbjct: 649  ---QFGVGSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRGSNFAP---ETGQTAGQFQT 702

Query: 1272 PPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVSMAGGNTNVQN 1330
              A G        WQ     + +  S+    QP   QPG        +SM G  +N  N
Sbjct: 703  RTAEGVGV--WPQWQGQQPHHRSSSSEQHVQQPPAQQPGQPEVFQEMLSMLGDQSNSYN 759



 Score = 31.6 bits (70), Expect = 5.6
 Identities = 47/230 (20%), Positives = 82/230 (35%), Gaps = 20/230 (8%)

Query: 1144 LPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLANRNS 1203
            L P++ LP++MG+ +L   AP+Q          PG    ++   SQ+      +    + 
Sbjct: 469  LGPTANLPLEMGSGQL---APRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSK 525

Query: 1204 MVSRGMTGNIGGQFGTGINPQMQQ-----NVFQYPG--AGMVPQGEANFAPSLSPGSSMV 1256
             + +       G F    +P+  +     N  Q  G  +  VP  +  F    S G++  
Sbjct: 526  PLEKS-----DGLFAQDRDPRFSEIYHNINADQSKGISSSTVPATQQLF----SQGNTFP 576

Query: 1257 PMPIPPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMS 1316
            P P P          PP +  Q           I  ++  +Q      TP     ++   
Sbjct: 577  PTPRPAENFRNSGLAPPVTIVQPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQ 636

Query: 1317 I-TVSMAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTG 1365
            + T + A   T+   +         SS+ +PG  T  P     P+L + G
Sbjct: 637  VATQATAKTRTSQFGVGSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRG 686


>gi|4502231 aryl hydrocarbon receptor nuclear translocator isoform 1
           [Homo sapiens]
          Length = 789

 Score = 74.3 bits (181), Expect = 8e-13
 Identities = 96/421 (22%), Positives = 172/421 (40%), Gaps = 68/421 (16%)

Query: 29  SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS 88
           S  E+RRR +   Y+ EL+++    +    +L+ KPDK  IL+  V     MK +    +
Sbjct: 95  SEIERRRRNKMTAYITELSDM----VPTCSALARKPDKLTILRMAVSH---MKSLRGTGN 147

Query: 89  TTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCE-GRIVFVSENVTSYLGYN 147
           T+ D   K          +  + L  L+LEA DGF F+V+CE GR+V+VS++VT  L   
Sbjct: 148 TSTDGSYKPSF-------LTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQP 200

Query: 148 QEELMNTSVYSILHVGD------HAEFVKNLLPKSLVN---------GVPWPQEATRRNS 192
           Q E   +++Y  +H  D           +N L   +++         G          + 
Sbjct: 201 QSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSR 260

Query: 193 HTFNCRMLIHPPD-EPGTENQEACQR----------------YEVMQC---------FTV 226
            +F CRM       +P + N+ +  R                + V+ C           V
Sbjct: 261 RSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGV 320

Query: 227 SQPKSIQEDGEDFQSCLICIAR-RLPRPPAITGVES------FMTKQDTTGKIISIDTSS 279
           S P    E G+  + CL+ I R ++   P  T + +      F+++ +  G    +D   
Sbjct: 321 SLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRC 380

Query: 280 LRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVM-TRGTASSPSYRFILNDGTML 338
           +   G    ++L+ K I  F  P+ ++    R  FQ+V+  +G   S  +RF   +   L
Sbjct: 381 VATVGYQP-QELLGKNIVEFCHPEDQQ--LLRDSFQQVVKLKGQVLSVMFRFRSKNQEWL 437

Query: 339 SAHTKCKLCYPQSPDMQPFIMGIHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAH 398
              T          D   +I+  +  + ++S   P+   ++ +  P++ P+ N  +    
Sbjct: 438 WMRTSSFTFQNPYSDEIEYIICTN-TNVKNSSQEPRPTLSNTIQRPQLGPTANLPLEMGS 496

Query: 399 G 399
           G
Sbjct: 497 G 497



 Score = 36.2 bits (82), Expect = 0.23
 Identities = 70/299 (23%), Positives = 98/299 (32%), Gaps = 42/299 (14%)

Query: 1050 APNQLRLQLQ-QRLQGQQQLIHQNRQAILNQFAATAPVGINMRSGMQQQITPQPPLNAQM 1108
            AP Q + Q +   + G+  L   N   ++     T P          + +     L AQ 
Sbjct: 500  APRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEH-------SKPLEKSDGLFAQD 552

Query: 1109 LAQRQRELYSQQHRQRQLIQQQRAMLMRQQSF--GNNLPPS---------SGL--PVQMG 1155
               R  E+Y   +  +        +   QQ F  GN  PP+         SGL  PV + 
Sbjct: 553  RDPRFSEIYHNINADQSKGISSSTVPATQQLFSQGNTFPPTPRPAENFRNSGLAPPVTIV 612

Query: 1156 NPRLPQG---APQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLANRNSMVSRGMTGN 1212
             P    G   A       P  G  P   P + S FS      +A+   R S         
Sbjct: 613  QPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQATAKTRTS--------- 663

Query: 1213 IGGQFGTG-INPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPIPPPQSSLLQQT 1271
               QFG G        +    PGA     G A +    + GS+  P      Q++   QT
Sbjct: 664  ---QFGVGSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRGSNFAP---ETGQTAGQFQT 717

Query: 1272 PPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVSMAGGNTNVQN 1330
              A G        WQ     + +  S+    QP   QPG        +SM G  +N  N
Sbjct: 718  RTAEGVGV--WPQWQGQQPHHRSSSSEQHVQQPPAQQPGQPEVFQEMLSMLGDQSNSYN 774



 Score = 31.6 bits (70), Expect = 5.6
 Identities = 47/230 (20%), Positives = 82/230 (35%), Gaps = 20/230 (8%)

Query: 1144 LPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLANRNS 1203
            L P++ LP++MG+ +L   AP+Q          PG    ++   SQ+      +    + 
Sbjct: 484  LGPTANLPLEMGSGQL---APRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSK 540

Query: 1204 MVSRGMTGNIGGQFGTGINPQMQQ-----NVFQYPG--AGMVPQGEANFAPSLSPGSSMV 1256
             + +       G F    +P+  +     N  Q  G  +  VP  +  F    S G++  
Sbjct: 541  PLEKS-----DGLFAQDRDPRFSEIYHNINADQSKGISSSTVPATQQLF----SQGNTFP 591

Query: 1257 PMPIPPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMS 1316
            P P P          PP +  Q           I  ++  +Q      TP     ++   
Sbjct: 592  PTPRPAENFRNSGLAPPVTIVQPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQ 651

Query: 1317 I-TVSMAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTG 1365
            + T + A   T+   +         SS+ +PG  T  P     P+L + G
Sbjct: 652  VATQATAKTRTSQFGVGSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRG 701


>gi|31745180 aryl hydrocarbon receptor nuclear translocator-like 2
           [Homo sapiens]
          Length = 636

 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 90/373 (24%), Positives = 158/373 (42%), Gaps = 57/373 (15%)

Query: 7   SSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDK 66
           SS        H+ K        S TEKRRR++ N  +EEL    SA I   + ++ K DK
Sbjct: 91  SSGSRVEDGEHQVKMKAFREAHSQTEKRRRDKMNNLIEEL----SAMIPQCNPMARKLDK 146

Query: 67  CKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFV 126
             +L+  V  ++ +K +      T+  V     S+     ++   L  L+L+  +GF FV
Sbjct: 147 LTVLRMAVQHLRSLKGL------TNSYVG----SNYRPSFLQDNELRHLILKTAEGFLFV 196

Query: 127 VNCE-GRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLP------KSLVN 179
           V CE G+I+FVS++V+  L Y+Q  L   S++  LH  D A+  + L        + L++
Sbjct: 197 VGCERGKILFVSKSVSKILNYDQASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREKLID 256

Query: 180 GVPWPQEATRRNS----------HTFNCRM---LIHPPDEPG---TENQEACQRYEVMQC 223
                Q  +  ++           +F CR+    I   +E G      ++  +++  + C
Sbjct: 257 AKTGLQVHSNLHAGRTRVYSGSRRSFFCRIKSCKISVKEEHGCLPNSKKKEHRKFYTIHC 316

Query: 224 --FTVSQPKSI---------QEDGEDFQSCLICIARRLPR-PPAITG-----VESFMTKQ 266
             +  S P +I         ++D  +F +CL+ I R  P   P  +G        F+T+ 
Sbjct: 317 TGYLRSWPPNIVGMEEERNSKKDNSNF-TCLVAIGRLQPYIVPQNSGEINVKPTEFITRF 375

Query: 267 DTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSP 326
              GK + +D  +    G    E L   C   F Q      +   +    + ++    + 
Sbjct: 376 AVNGKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHNNLTDKHKAV--LQSKEKILTD 433

Query: 327 SYRFILNDGTMLS 339
           SY+F   DG+ ++
Sbjct: 434 SYKFRAKDGSFVT 446


>gi|115430245 arylhydrocarbon receptor repressor [Homo sapiens]
          Length = 719

 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 51/164 (31%), Positives = 81/164 (49%), Gaps = 10/164 (6%)

Query: 29  SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMK--RMEQE 86
           S+  KR R++ N  L+ LA LL      I  L    DK  +L+ +V  +++    ++ QE
Sbjct: 34  SNPSKRHRDRLNAELDHLASLLPFPPDIISKL----DKLSVLRLSVSYLRVKSFFQVVQE 89

Query: 87  KSTTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGY 146
           +S+            S          G LLLE+L+GF  VV+ EG I + S  +  YLG+
Sbjct: 90  QSSRQPAAGAPSPGDSCPLAGSAVLEGRLLLESLNGFALVVSAEGTIFYASATIVDYLGF 149

Query: 147 NQEELMNTSVYSILHVGDHAEFVKNLL----PKSLVNGVPWPQE 186
           +Q ++M+ ++Y  +HV D  +F + L     P  +V G P P E
Sbjct: 150 HQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQPPPLE 193


>gi|30795240 aryl hydrocarbon receptor nuclear translocator isoform
           2 [Homo sapiens]
          Length = 328

 Score = 71.6 bits (174), Expect = 5e-12
 Identities = 46/137 (33%), Positives = 72/137 (52%), Gaps = 15/137 (10%)

Query: 29  SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS 88
           S  E+RRR +   Y+ EL+++    +    +L+ KPDK  IL+  V     MK +    +
Sbjct: 95  SEIERRRRNKMTAYITELSDM----VPTCSALARKPDKLTILRMAVSH---MKSLRGTGN 147

Query: 89  TTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCE-GRIVFVSENVTSYLGYN 147
           T+ D   K          +  + L  L+LEA DGF F+V+CE GR+V+VS++VT  L   
Sbjct: 148 TSTDGSYKPSF-------LTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQP 200

Query: 148 QEELMNTSVYSILHVGD 164
           Q E   +++Y  +H  D
Sbjct: 201 QSEWFGSTLYDQVHPDD 217


>gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens]
          Length = 901

 Score = 71.6 bits (174), Expect = 5e-12
 Identities = 46/152 (30%), Positives = 77/152 (50%), Gaps = 16/152 (10%)

Query: 33  KRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDD 92
           + RR +EN    ELA+LL    +    L    DK  I++ T+  +++     Q     + 
Sbjct: 31  RSRRGKENFEFYELAKLLPLPAAITSQL----DKASIIRLTISYLKMRDFANQGDPPWNL 86

Query: 93  DVQKSDISSSSQGVIEKES------------LGPLLLEALDGFFFVVNCEGRIVFVSENV 140
            ++    ++S +G   + S            LG  +L++LDGF F +N EG+ +++SE V
Sbjct: 87  RMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLYISETV 146

Query: 141 TSYLGYNQEELMNTSVYSILHVGDHAEFVKNL 172
           + YLG +Q EL  +SV+  +H GDH E  + L
Sbjct: 147 SIYLGLSQVELTGSSVFDYVHPGDHVEMAEQL 178


>gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a
           [Homo sapiens]
          Length = 667

 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 83/380 (21%), Positives = 149/380 (39%), Gaps = 42/380 (11%)

Query: 33  KRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDD 92
           + RR QE + L +LA  L         +S   DK  I++ T+  +++ +           
Sbjct: 22  RSRRSQETEVLYQLAHTLPF----ARGVSAHLDKASIMRLTISYLRMHRLCAA------- 70

Query: 93  DVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELM 152
                     +Q     E L    L+AL+GF  V+  EG + ++SENV+ +LG +Q EL+
Sbjct: 71  -------GEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELI 123

Query: 153 NTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPDEPGTENQ 212
             S++  +H  D  E    L P+  ++     ++        F+ RM         T N 
Sbjct: 124 GHSIFDFIHPCDQEELQDALTPQQTLS----RRKVEAPTERCFSLRMKSTLTSRGRTLNL 179

Query: 213 EACQRYEVMQCF--------TVSQPKSIQEDGEDFQSCLICIARRLPRPPAI---TGVES 261
           +A   ++V+ C               +   D E    CL+ I   +P P ++    G  +
Sbjct: 180 KAA-TWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGA 238

Query: 262 FMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRG 321
           F+++     K    D      AG +  +DL+    Y +      +     +    ++++G
Sbjct: 239 FLSRHSLDMKFTYCDDRIAEVAGYSP-DDLIGCSAYEYI--HALDSDAVSKSIHTLLSKG 295

Query: 322 TASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMGIH--IIDREHSGL---SPQDD 376
            A +  YRF+   G  L   T+  +           I+ +H  I   E +G+     Q +
Sbjct: 296 QAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTE 355

Query: 377 TNSGMSIPRVNPSVNPSISP 396
            +S   I R  PS   + +P
Sbjct: 356 QHSRRPIQRGAPSQKDTPNP 375


>gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c
           [Homo sapiens]
          Length = 669

 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 83/380 (21%), Positives = 149/380 (39%), Gaps = 42/380 (11%)

Query: 33  KRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDD 92
           + RR QE + L +LA  L         +S   DK  I++ T+  +++ +           
Sbjct: 24  RSRRSQETEVLYQLAHTLPF----ARGVSAHLDKASIMRLTISYLRMHRLCAA------- 72

Query: 93  DVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELM 152
                     +Q     E L    L+AL+GF  V+  EG + ++SENV+ +LG +Q EL+
Sbjct: 73  -------GEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELI 125

Query: 153 NTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPDEPGTENQ 212
             S++  +H  D  E    L P+  ++     ++        F+ RM         T N 
Sbjct: 126 GHSIFDFIHPCDQEELQDALTPQQTLS----RRKVEAPTERCFSLRMKSTLTSRGRTLNL 181

Query: 213 EACQRYEVMQCF--------TVSQPKSIQEDGEDFQSCLICIARRLPRPPAI---TGVES 261
           +A   ++V+ C               +   D E    CL+ I   +P P ++    G  +
Sbjct: 182 KAA-TWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGA 240

Query: 262 FMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRG 321
           F+++     K    D      AG +  +DL+    Y +      +     +    ++++G
Sbjct: 241 FLSRHSLDMKFTYCDDRIAEVAGYSP-DDLIGCSAYEYI--HALDSDAVSKSIHTLLSKG 297

Query: 322 TASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMGIH--IIDREHSGL---SPQDD 376
            A +  YRF+   G  L   T+  +           I+ +H  I   E +G+     Q +
Sbjct: 298 QAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTE 357

Query: 377 TNSGMSIPRVNPSVNPSISP 396
            +S   I R  PS   + +P
Sbjct: 358 QHSRRPIQRGAPSQKDTPNP 377


>gi|4502003 aryl hydrocarbon receptor [Homo sapiens]
          Length = 848

 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 46/160 (28%), Positives = 82/160 (51%), Gaps = 16/160 (10%)

Query: 20  KGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQL 79
           K  P + + S+  KR R++ N  L+ LA LL      I+ L    DK  +L+ +V  ++ 
Sbjct: 24  KPIPAEGIKSNPSKRHRDRLNTELDRLASLLPFPQDVINKL----DKLSVLRLSVSYLRA 79

Query: 80  -------MKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGR 132
                  +K    E++   D+ + ++     +G+  +E  G  LL+AL+GF  VV  +  
Sbjct: 80  KSFFDVALKSSPTERNGGQDNCRAANFR---EGLNLQE--GEFLLQALNGFVLVVTTDAL 134

Query: 133 IVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNL 172
           + + S  +  YLG+ Q ++++ SVY ++H  D AEF + L
Sbjct: 135 VFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQL 174


>gi|22027482 neuronal PAS domain protein 1 [Homo sapiens]
          Length = 590

 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 47/168 (27%), Positives = 88/168 (52%), Gaps = 12/168 (7%)

Query: 33  KRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMK--RMEQEKSTT 90
           + RR +EN    ELA+LL        ++S + DK  I++ +V  ++L +   +       
Sbjct: 55  RSRRGKENLEFFELAKLLPLP----GAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGL 110

Query: 91  DDDVQKSDISSSSQGV------IEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYL 144
                 + ++   +G       + ++ LG  +L++LDGF F +N EG+ +++SE V+ YL
Sbjct: 111 RAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYL 170

Query: 145 GYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNS 192
           G +Q E+  +SV+  +H GDH+E ++ L  ++   G P P   +  +S
Sbjct: 171 GLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSS 218


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 67.8 bits (164), Expect = 7e-11
 Identities = 85/372 (22%), Positives = 149/372 (40%), Gaps = 10/372 (2%)

Query: 375  DDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINRQQSSDLHSSSHSNS 434
            D +NS  S    + S + S + +     S +   SNS+  S   +    SD  SS+ S+S
Sbjct: 802  DSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDS 861

Query: 435  SNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTGISLAQFMSPRRQVT 494
            SNS  S   S  S    +   +    SS SS+ S + N+S  + +  S +   S     +
Sbjct: 862  SNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSD----S 917

Query: 495  SGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTSLQGMNEGPNNSVGF 554
            S  +      N+S   N S  S+    + S+ ++N+   SN   +S    +   N+S   
Sbjct: 918  SNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSS 977

Query: 555  SASSPVLRQMSSQNSPSRLNIQPA-KAESKDNKEIASILNEMIQSDNSSSDGKPLDSGLL 613
             +S+      SS +S S  +   +  ++S D+ + +   N    S++S S      S   
Sbjct: 978  DSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSS 1037

Query: 614  HNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSCTGTSNSASANSSG 673
             ++D     DS  S  S        ++       +   +   D    + +S+S++++ S 
Sbjct: 1038 DSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSS 1097

Query: 674  GSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVSVTGQVQGNSSIKL 733
             S  SS SS +             + SD +  S   D  DS+++S S       +SS   
Sbjct: 1098 DSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSS--- 1154

Query: 734  ELDASKKKESKD 745
              D+S   +S D
Sbjct: 1155 --DSSDSSDSSD 1164



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 90/391 (23%), Positives = 150/391 (38%), Gaps = 11/391 (2%)

Query: 365 DREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINRQQSS 424
           D + S  S   D++        + S + S S +      S    S+S   S+  N   SS
Sbjct: 592 DSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSS 651

Query: 425 D----LHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTG 480
           D      SS+ SNSS+S  S   S  S    +   +    SS SSN S + ++S    + 
Sbjct: 652 DNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSD 711

Query: 481 ISLAQFMSPRR-----QVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSN 535
            S +   S           S  ++     ++S   + S+ SS    +S + N+++ S S+
Sbjct: 712 SSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSS 771

Query: 536 IPVTSLQGMNEG-PNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNE 594
               S    N    N+S   S SS       S NS    +   +      N   +S  ++
Sbjct: 772 DSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSD 831

Query: 595 MIQSDNSSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSC 654
              S NSS      DS    ++D  +  DS  S  S        ++       ++  ++ 
Sbjct: 832 SSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNS 891

Query: 655 KDVLSCTGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDS 714
            D    + +S+S S++SS  S  SS SS +             + SD +  S   D  DS
Sbjct: 892 SDSSDSSNSSDSDSSDSSNSS-DSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDS 950

Query: 715 ASTSVSVTGQVQGNSSIKLELDASKKKESKD 745
           +++S S       NSS   + ++S   +S +
Sbjct: 951 SNSSDSSNSSDSSNSSDSSDSNSSDSSDSSN 981



 Score = 59.3 bits (142), Expect = 3e-08
 Identities = 77/369 (20%), Positives = 144/369 (39%), Gaps = 20/369 (5%)

Query: 409 SNSNMVSTRINRQQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPS 468
           S+++  S+  +   SSD +SSS S+SS+S  S      S   +N + +   + S  S+ S
Sbjct: 557 SSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDS 616

Query: 469 LNLNNSPMEGTGISLAQFMSPRRQVTSGLATRPRMPN----------NSFPPNISTLSSP 518
            + ++S  + +        S  +  +S   +     N          NS   + S+ SS 
Sbjct: 617 SDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSD 676

Query: 519 VGMTSSACNNNNRSYSNIPVTSLQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPA 578
              +S + N+++ S S+    S +  +   ++    S SS      SS +  S  +    
Sbjct: 677 SSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSD 736

Query: 579 KAESKDNKEIASILNEMIQSDNSSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLT 638
            + S D+ + +   N    SD+S S      S    ++D     +S  S  S        
Sbjct: 737 SSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSD 796

Query: 639 TTAEQQLRHADIDTSCKDVLSCTGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGS 698
           ++      ++   +   D      +++S S+NSS  S  S+ S  ++          +GS
Sbjct: 797 SSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSD-----SSDGS 851

Query: 699 PSDITTLSVEPDKKDSASTSVSVTGQVQGNSSIKLELDASKKKESKDHQLLRYLLDKDEK 758
            SD +  S   +  DS+ +S S       +SS     D+++   S D        D D  
Sbjct: 852 DSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSS-----DSNESSNSSDSSDSSNSSDSDSS 906

Query: 759 DLRSTPNLS 767
           D  ++ + S
Sbjct: 907 DSSNSSDSS 915



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 86/377 (22%), Positives = 148/377 (39%), Gaps = 15/377 (3%)

Query: 375  DDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINRQQSSDLHSSSHSN- 433
            + +NS  S    N S + S   ++    S +   S+S+  S   +   SSD  +SS S+ 
Sbjct: 887  ESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSD 946

Query: 434  ---SSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTGISLAQFMSPR 490
               SSNS  S   S  S    N + +    SS SS+ S + ++S    +  S     S  
Sbjct: 947  SSDSSNSSDSSNSSDSS----NSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSN 1002

Query: 491  RQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTSLQGMNEGPNN 550
               +S  +      N+S   N S  S+    + S+ ++++   S+   +S    +   ++
Sbjct: 1003 SSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSD 1062

Query: 551  SVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDNSSSDGKPLDS 610
            S   S SS      SS +S S  + + + +    N   +S  ++   S +SS      DS
Sbjct: 1063 SSDSSDSSD-----SSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDS 1117

Query: 611  GLLHNNDRLSD-GDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSCTGTSNSASA 669
                N+   SD  DS  S  S        ++       +   +   D    + +S+S+ +
Sbjct: 1118 SDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDS 1177

Query: 670  NSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVSVTGQVQGNS 729
            ++S  S  SS SS +               SD +  S   D  DS+ +S S       +S
Sbjct: 1178 SNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDS 1237

Query: 730  SIKLE-LDASKKKESKD 745
            S   +  D+S   +S D
Sbjct: 1238 SDSSDSSDSSNSSDSSD 1254



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 82/386 (21%), Positives = 145/386 (37%), Gaps = 23/386 (5%)

Query: 365  DREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINRQQSS 424
            D   S  S   D++   +    + S N S S       S++   SNS+  S   +   SS
Sbjct: 893  DSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSES----SNSSDNSNSSDSSNSSDSSDSS 948

Query: 425  DLHSSS-HSNSSNSQGSFGCSPGSQIVANVALNQGQAS----SQSSNPSLNLNNSPMEGT 479
            D  +SS  SNSS+S  S   S  +   ++ + N   +S    S  S+ S + +NS     
Sbjct: 949  DSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSD 1008

Query: 480  GISLAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVT 539
                +   +      S  ++     ++S   + S+ SS    +S + N+++ S S+    
Sbjct: 1009 SSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSD 1068

Query: 540  SLQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSD 599
            S    +   ++    S+ S      S  +  S  +     ++S D+ + +   N    SD
Sbjct: 1069 SSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSD 1128

Query: 600  NSSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLS 659
            +S S      S    ++D     DS  S  S        ++       +   +   D   
Sbjct: 1129 SSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSD 1188

Query: 660  CTGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSV 719
             + +S+S+ ++ S  S  SS SS +               SD +  S   D  +S+ +S 
Sbjct: 1189 SSDSSDSSDSSDSSDSSDSSDSSDSS---------DSSDSSDSSDSSDSSDSNESSDSSD 1239

Query: 720  SVTGQVQGNSSIKLELDASKKKESKD 745
            S       NSS     D+S   +S D
Sbjct: 1240 SSDSSDSSNSS-----DSSDSSDSSD 1260



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 70/328 (21%), Positives = 136/328 (41%), Gaps = 12/328 (3%)

Query: 420 RQQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGT 479
           +  SSD  SS  SNSS+S  S          ++ + +    SS SS+   + +++  + +
Sbjct: 546 KSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSS 605

Query: 480 GISLAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVT 539
             S +   S     +   +   +  ++S   +  + SS    + S+ N+++   SN   +
Sbjct: 606 DSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSN---S 662

Query: 540 SLQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSD 599
           S    +   ++S   S+SS       S +S    N     +ES D+ + +S  +    SD
Sbjct: 663 SNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSN----SSESSDSSD-SSDSDSSDSSD 717

Query: 600 NSSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLS 659
           +S+S+    DS   +++D     +S  S  S        ++      ++   +   D   
Sbjct: 718 SSNSNSSDSDSS--NSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSD 775

Query: 660 CTGTSNSASANSSGGSCPSSHSSLT--ERHKILHRLLQEGSPSDITTLSVEPDKKDSAST 717
            + +SNS+ +N S  S  SS SS +    +        + S SD +  S   +  DS+ +
Sbjct: 776 SSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDS 835

Query: 718 SVSVTGQVQGNSSIKLELDASKKKESKD 745
           S S       +SS   + D+S + +S +
Sbjct: 836 SNSSDSSDSSDSSDGSDSDSSNRSDSSN 863



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 67/322 (20%), Positives = 122/322 (37%), Gaps = 8/322 (2%)

Query: 367  EHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINRQQSSDL 426
            + S  S   D+NS  S    N S +   S +   + SS     +SN   +  +   S   
Sbjct: 961  DSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSS----DSSNSSDSSDSSDSSDSS 1016

Query: 427  HSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTGISLAQF 486
            +SS  SNSS+S  S   S  S    +   +    SS SSN S + ++S    +  S    
Sbjct: 1017 NSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSS 1076

Query: 487  MSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTSLQGMNE 546
             S     +S  +      +NS   + S+ SS    +S + ++++ S S+    S    + 
Sbjct: 1077 DSSDSSESSDSSD----SSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDS 1132

Query: 547  GPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDNSSSDGK 606
              ++    S+ S    + S  +  S  +     ++S D+ + +   N    SD+S S   
Sbjct: 1133 SDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDS 1192

Query: 607  PLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSCTGTSNS 666
               S    ++D     DS  S  S        ++       +   +   D    + +S+S
Sbjct: 1193 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDS 1252

Query: 667  ASANSSGGSCPSSHSSLTERHK 688
            + ++ S  S   S+     + K
Sbjct: 1253 SDSSDSSDSTSDSNDESDSQSK 1274



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 75/329 (22%), Positives = 130/329 (39%), Gaps = 12/329 (3%)

Query: 423 SSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTGIS 482
           + D +S S +NSS+   +   S  S+   N + ++G A    S+ + + NNS   G G +
Sbjct: 474 NDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKG-AEDDDSDSTSDTNNSDSNGNGNN 532

Query: 483 LAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNR----SYSNIPV 538
                    +  SG        ++S   + S+ SS    + S+ +N++     S S+   
Sbjct: 533 ---GNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSD 589

Query: 539 TSLQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDN--KEIASILNEMI 596
           +S    ++  N+S    +S       SS +S S+ +   ++++S D+  K  +S  N   
Sbjct: 590 SSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSD 649

Query: 597 QSDNSSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKD 656
            SDNS S      S    ++D     DS  S  S        ++       +   +   D
Sbjct: 650 SSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSD 709

Query: 657 VLSCTGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSAS 716
             S   + +S S +S   S  SS SS +             + SD +  S   +  DS+ 
Sbjct: 710 SDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSD 769

Query: 717 TSVSVTGQVQGNSSIKLELDASKKKESKD 745
           +S S       NSS     D+S   +S D
Sbjct: 770 SSDSSDSSDSSNSSD--SNDSSNSSDSSD 796



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 62/274 (22%), Positives = 110/274 (40%), Gaps = 10/274 (3%)

Query: 365  DREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINRQQSS 424
            D  +S  S     +S  S    +   + S + +     S +   S+S+  S   +  +SS
Sbjct: 1026 DSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESS 1085

Query: 425  DLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTGISLA 484
            D  SS  SNSS+S  S   S  S    +   +    SS SS+ S + ++S    +  S  
Sbjct: 1086 D--SSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSD 1143

Query: 485  QFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTSLQGM 544
               S     +S  +      ++S   + S  SS    +S + ++++ S S+    S    
Sbjct: 1144 SSDSSESSDSSDSSDSSDSSDSSDSSDSSD-SSDSSNSSDSSDSSDSSDSSDSSDSSDSS 1202

Query: 545  NEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDNSSSD 604
            +   ++    S+ S      S  +  S  N     ++S D+ + ++  +    SD+S S 
Sbjct: 1203 DSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDST 1262

Query: 605  GKPLD-------SGLLHNNDRLSDGDSKYSQTSH 631
                D       SG  +NN   SD DS+ S ++H
Sbjct: 1263 SDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNH 1296



 Score = 36.2 bits (82), Expect = 0.23
 Identities = 64/317 (20%), Positives = 111/317 (35%), Gaps = 41/317 (12%)

Query: 499 TRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTSLQGMNEGPNNSVGFSASS 558
           T+  + N   P   S   + VG +++  ++N+  Y +          + PN+S   + + 
Sbjct: 416 TQGEVVNIEGPGQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGND 475

Query: 559 PVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDNSSSDGKPLDSGLLHNNDR 618
               + S  NS SR +      ESKDN   +          +S+SD    DS    NN  
Sbjct: 476 DANSE-SDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGN 534

Query: 619 LSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSCTGTSNSASANSSGGSCPS 678
             D D   S                       D+S  D  S   +++S S++SS      
Sbjct: 535 -DDNDKSDSGKGKS------------------DSSDSD--SSDSSNSSDSSDSSDSDSSD 573

Query: 679 SHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVSVTGQVQGNSSIKLELDAS 738
           S+SS               S SD    S + D  DS+ +  S +     +S      D+S
Sbjct: 574 SNSS---------------SDSD----SSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSS 614

Query: 739 KKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQMDPCNTNPTPMTKPTPEE 798
              +S D +      + D  D  S  + S  +     +  +  D  N++ +  +  + + 
Sbjct: 615 DSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDS 674

Query: 799 IKLEAQSQFTADLDQFD 815
               + S  +   D  D
Sbjct: 675 SDSSSSSDSSNSSDSSD 691


>gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b
           [Homo sapiens]
          Length = 613

 Score = 67.8 bits (164), Expect = 7e-11
 Identities = 69/303 (22%), Positives = 123/303 (40%), Gaps = 24/303 (7%)

Query: 110 ESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFV 169
           E L    L+AL+GF  V+  EG + ++SENV+ +LG +Q EL+  S++  +H  D  E  
Sbjct: 27  EPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQ 86

Query: 170 KNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCF----- 224
             L P+  ++     ++        F+ RM         T N +A   ++V+ C      
Sbjct: 87  DALTPQQTLS----RRKVEAPTERCFSLRMKSTLTSRGRTLNLKAA-TWKVLNCSGHMRA 141

Query: 225 ---TVSQPKSIQEDGEDFQSCLICIARRLPRPPAI---TGVESFMTKQDTTGKIISIDTS 278
                    +   D E    CL+ I   +P P ++    G  +F+++     K    D  
Sbjct: 142 YKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDR 201

Query: 279 SLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTML 338
               AG +  +DL+    Y +      +     +    ++++G A +  YRF+   G  L
Sbjct: 202 IAEVAGYSP-DDLIGCSAYEYI--HALDSDAVSKSIHTLLSKGQAVTGQYRFLARSGGYL 258

Query: 339 SAHTKCKLCYPQSPDMQPFIMGIH--IIDREHSGL---SPQDDTNSGMSIPRVNPSVNPS 393
              T+  +           I+ +H  I   E +G+     Q + +S   I R  PS   +
Sbjct: 259 WTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQRGAPSQKDT 318

Query: 394 ISP 396
            +P
Sbjct: 319 PNP 321


>gi|40254439 endothelial PAS domain protein 1 [Homo sapiens]
          Length = 870

 Score = 67.4 bits (163), Expect = 9e-11
 Identities = 75/325 (23%), Positives = 135/325 (41%), Gaps = 34/325 (10%)

Query: 35  RREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDV 94
           RR +E +   ELA  L        S+S   DK  I++  +  ++  K +    S  + + 
Sbjct: 26  RRSKETEVFYELAHELPLP----HSVSSHLDKASIMRLAISFLRTHKLLSSVCSENESEA 81

Query: 95  QKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNT 154
           +              + +  L L+AL+GF  VV  +G ++F+SEN++ ++G  Q EL   
Sbjct: 82  EAD------------QQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMGLTQVELTGH 129

Query: 155 SVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNS-HTFNCRMLIHPPDEPGTENQE 213
           S++   H  DH E  +NL   SL NG  + +++   ++   F  RM     +   T N +
Sbjct: 130 SIFDFTHPCDHEEIRENL---SLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRGRTVNLK 186

Query: 214 ACQRYEVMQC------FTVSQP-KSIQEDGEDFQSCLICIARRLPRPPAI---TGVESFM 263
           +   ++V+ C      +    P  S+    E   SCLI +   +  P  +      ++F+
Sbjct: 187 SA-TWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLDSKTFL 245

Query: 264 TKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRGTA 323
           ++     K    D       G    E+L+ +  Y F+     E     +  Q + T+G  
Sbjct: 246 SRHSMDMKFTYCDDRITELIGYHP-EELLGRSAYEFYHALDSE--NMTKSHQNLCTKGQV 302

Query: 324 SSPSYRFILNDGTMLSAHTKCKLCY 348
            S  YR +   G  +   T+  + Y
Sbjct: 303 VSGQYRMLAKHGGYVWLETQGTVIY 327


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.127    0.361 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,002,351
Number of Sequences: 37866
Number of extensions: 3080427
Number of successful extensions: 16099
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 90
Number of HSP's successfully gapped in prelim test: 528
Number of HSP's that attempted gapping in prelim test: 12790
Number of HSP's gapped (non-prelim): 2659
length of query: 1399
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1284
effective length of database: 13,892,928
effective search space: 17838519552
effective search space used: 17838519552
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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