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Search of human proteins with 221139921
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|221139921 EF-hand calcium binding domain 8 [Homo sapiens]
(1288 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|221139921 EF-hand calcium binding domain 8 [Homo sapiens] 2619 0.0
gi|30520335 WD repeat domain 49 [Homo sapiens] 145 2e-34
gi|115495443 WD repeat domain 64 [Homo sapiens] 119 1e-26
gi|16554629 WD repeat domain 5 [Homo sapiens] 71 8e-12
gi|16554627 WD repeat domain 5 [Homo sapiens] 71 8e-12
gi|23199987 WD repeat domain 5B [Homo sapiens] 66 2e-10
gi|18874090 WD repeat domain 48 [Homo sapiens] 64 1e-09
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 63 2e-09
gi|157266266 WD repeat domain 86 [Homo sapiens] 61 6e-09
gi|32189425 WD repeat domain 69 [Homo sapiens] 60 2e-08
gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom... 59 2e-08
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 58 7e-08
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 58 7e-08
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 58 7e-08
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 56 3e-07
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 56 3e-07
gi|26665869 WD repeat domain 51B [Homo sapiens] 55 4e-07
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 55 6e-07
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 55 6e-07
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 55 6e-07
gi|110815834 F-box and WD-40 domain protein 10 [Homo sapiens] 54 1e-06
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 53 2e-06
gi|157694487 CMT1A duplicated region transcript 1 [Homo sapiens] 52 4e-06
gi|62234438 Notchless gene homolog isoform b [Homo sapiens] 52 4e-06
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 52 4e-06
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [... 50 2e-05
gi|21071067 TBP-associated factor 5 [Homo sapiens] 49 3e-05
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ... 49 3e-05
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 47 9e-05
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 47 1e-04
>gi|221139921 EF-hand calcium binding domain 8 [Homo sapiens]
Length = 1288
Score = 2619 bits (6788), Expect = 0.0
Identities = 1288/1288 (100%), Positives = 1288/1288 (100%)
Query: 1 MSSEDLAEIPQLQKLSIPHGFQNKEAASSPTPSITLSQVPDLQPGSQLFTEIHLAKIEKM 60
MSSEDLAEIPQLQKLSIPHGFQNKEAASSPTPSITLSQVPDLQPGSQLFTEIHLAKIEKM
Sbjct: 1 MSSEDLAEIPQLQKLSIPHGFQNKEAASSPTPSITLSQVPDLQPGSQLFTEIHLAKIEKM 60
Query: 61 FEEDINSTGALGMDAFIKAMKKVLSSVSDEMLKELFLKVDSDCEGFVTWQKYVDYMMREF 120
FEEDINSTGALGMDAFIKAMKKVLSSVSDEMLKELFLKVDSDCEGFVTWQKYVDYMMREF
Sbjct: 61 FEEDINSTGALGMDAFIKAMKKVLSSVSDEMLKELFLKVDSDCEGFVTWQKYVDYMMREF 120
Query: 121 QGKEDMRKSQYRLHFYLPMTVVPLNHGCEVVKVVFLIHRFKKIGCFLTVTKDGILQFWSE 180
QGKEDMRKSQYRLHFYLPMTVVPLNHGCEVVKVVFLIHRFKKIGCFLTVTKDGILQFWSE
Sbjct: 121 QGKEDMRKSQYRLHFYLPMTVVPLNHGCEVVKVVFLIHRFKKIGCFLTVTKDGILQFWSE 180
Query: 181 SFSLMSSFRLNQTQQLYNQPMWVIDMVCLHNMNLVAVASTRQKIDFFDISDHKCVRAFTF 240
SFSLMSSFRLNQTQQLYNQPMWVIDMVCLHNMNLVAVASTRQKIDFFDISDHKCVRAFTF
Sbjct: 181 SFSLMSSFRLNQTQQLYNQPMWVIDMVCLHNMNLVAVASTRQKIDFFDISDHKCVRAFTF 240
Query: 241 VDLDSCALVMDYWSDYHRGVFCYGDAKGNVIVFTSENMTSGLFNPRILPRASKWDHWIKV 300
VDLDSCALVMDYWSDYHRGVFCYGDAKGNVIVFTSENMTSGLFNPRILPRASKWDHWIKV
Sbjct: 241 VDLDSCALVMDYWSDYHRGVFCYGDAKGNVIVFTSENMTSGLFNPRILPRASKWDHWIKV 300
Query: 301 SLQKLLNEKSALHRSYRLKALHPNWCEQVKFIPQMNVVVSCSAIEKSSLVLTILPAKASK 360
SLQKLLNEKSALHRSYRLKALHPNWCEQVKFIPQMNVVVSCSAIEKSSLVLTILPAKASK
Sbjct: 301 SLQKLLNEKSALHRSYRLKALHPNWCEQVKFIPQMNVVVSCSAIEKSSLVLTILPAKASK 360
Query: 361 KPRLSVLRLRKGILCFDYCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHIL 420
KPRLSVLRLRKGILCFDYCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHIL
Sbjct: 361 KPRLSVLRLRKGILCFDYCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHIL 420
Query: 421 VDSRNNSILISVSKDKNIRVWDMLDYICLQSFCGKFFALGNCPITSAYFFEKDNTLICST 480
VDSRNNSILISVSKDKNIRVWDMLDYICLQSFCGKFFALGNCPITSAYFFEKDNTLICST
Sbjct: 421 VDSRNNSILISVSKDKNIRVWDMLDYICLQSFCGKFFALGNCPITSAYFFEKDNTLICST 480
Query: 481 YSIGILKGYLEAQGLIKARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGRKT 540
YSIGILKGYLEAQGLIKARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGRKT
Sbjct: 481 YSIGILKGYLEAQGLIKARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGRKT 540
Query: 541 MEFAVSGGQHVEMTAMALDESERCLLTGLRDGTMKMWNYNIGKCLLTFPSPEQLEISGII 600
MEFAVSGGQHVEMTAMALDESERCLLTGLRDGTMKMWNYNIGKCLLTFPSPEQLEISGII
Sbjct: 541 MEFAVSGGQHVEMTAMALDESERCLLTGLRDGTMKMWNYNIGKCLLTFPSPEQLEISGII 600
Query: 601 HMNKVFYVTGWSKRITHFLFHKTKPVLLCYHWQTYHTEDILSMAKYRNQFLGTSSYSGDI 660
HMNKVFYVTGWSKRITHFLFHKTKPVLLCYHWQTYHTEDILSMAKYRNQFLGTSSYSGDI
Sbjct: 601 HMNKVFYVTGWSKRITHFLFHKTKPVLLCYHWQTYHTEDILSMAKYRNQFLGTSSYSGDI 660
Query: 661 LFWNTGTLKPIFNFNASRSPSPLQPKRVQDVNNCLAESHRPSRPYVEREKWTYKTSRKLS 720
LFWNTGTLKPIFNFNASRSPSPLQPKRVQDVNNCLAESHRPSRPYVEREKWTYKTSRKLS
Sbjct: 661 LFWNTGTLKPIFNFNASRSPSPLQPKRVQDVNNCLAESHRPSRPYVEREKWTYKTSRKLS 720
Query: 721 SLSPESVANTNLRRSLVSAPPVMRCPRDKEPDRPVPQQKPSSASGTSRQSSKIHSKQSIY 780
SLSPESVANTNLRRSLVSAPPVMRCPRDKEPDRPVPQQKPSSASGTSRQSSKIHSKQSIY
Sbjct: 721 SLSPESVANTNLRRSLVSAPPVMRCPRDKEPDRPVPQQKPSSASGTSRQSSKIHSKQSIY 780
Query: 781 KEDETRKGEWQKNMLVQSSASVEKIIFLQTRPRLPHTAALLSSCMDGYIYAWSLHENGGL 840
KEDETRKGEWQKNMLVQSSASVEKIIFLQTRPRLPHTAALLSSCMDGYIYAWSLHENGGL
Sbjct: 781 KEDETRKGEWQKNMLVQSSASVEKIIFLQTRPRLPHTAALLSSCMDGYIYAWSLHENGGL 840
Query: 841 LGKFPVDLDNGDVVVGAMATDKNDWILITGDCKGYIKIWDIKDYCALIDKQPFQSSGAKV 900
LGKFPVDLDNGDVVVGAMATDKNDWILITGDCKGYIKIWDIKDYCALIDKQPFQSSGAKV
Sbjct: 841 LGKFPVDLDNGDVVVGAMATDKNDWILITGDCKGYIKIWDIKDYCALIDKQPFQSSGAKV 900
Query: 901 VSEAHNKFRLLIPQQLGTNFPHYIPLEDKEVVAGHTISLVPPTLLMTWKGHLNSVADILY 960
VSEAHNKFRLLIPQQLGTNFPHYIPLEDKEVVAGHTISLVPPTLLMTWKGHLNSVADILY
Sbjct: 901 VSEAHNKFRLLIPQQLGTNFPHYIPLEDKEVVAGHTISLVPPTLLMTWKGHLNSVADILY 960
Query: 961 VDNFQLVISAGQDRDVKAWKLSGDAIGTFGLSVWKRLQDACDGPRENRASLEEDGDSTGT 1020
VDNFQLVISAGQDRDVKAWKLSGDAIGTFGLSVWKRLQDACDGPRENRASLEEDGDSTGT
Sbjct: 961 VDNFQLVISAGQDRDVKAWKLSGDAIGTFGLSVWKRLQDACDGPRENRASLEEDGDSTGT 1020
Query: 1021 TQKVLHLELQEQRDLAEALIYQRREQAALMALLHGKADKEADTWAKLQKMALMSPWAGER 1080
TQKVLHLELQEQRDLAEALIYQRREQAALMALLHGKADKEADTWAKLQKMALMSPWAGER
Sbjct: 1021 TQKVLHLELQEQRDLAEALIYQRREQAALMALLHGKADKEADTWAKLQKMALMSPWAGER 1080
Query: 1081 PLEDIEDSWNKWESRDKQVSKVLGAAYKPKERLQNTRFLSTRVPYGWMKHQISPQVYQSL 1140
PLEDIEDSWNKWESRDKQVSKVLGAAYKPKERLQNTRFLSTRVPYGWMKHQISPQVYQSL
Sbjct: 1081 PLEDIEDSWNKWESRDKQVSKVLGAAYKPKERLQNTRFLSTRVPYGWMKHQISPQVYQSL 1140
Query: 1141 HFSDLMPTQQPDFLTSRGPDQQDQHIRLVAHHVQKDLVPSREQAVLDTTDSTPAAASSPS 1200
HFSDLMPTQQPDFLTSRGPDQQDQHIRLVAHHVQKDLVPSREQAVLDTTDSTPAAASSPS
Sbjct: 1141 HFSDLMPTQQPDFLTSRGPDQQDQHIRLVAHHVQKDLVPSREQAVLDTTDSTPAAASSPS 1200
Query: 1201 SLLSVTASASRLLDSSLPTFLTPQFSFLLRPQSASTAHSTPSVPSPVSKSTLQGSVTPKH 1260
SLLSVTASASRLLDSSLPTFLTPQFSFLLRPQSASTAHSTPSVPSPVSKSTLQGSVTPKH
Sbjct: 1201 SLLSVTASASRLLDSSLPTFLTPQFSFLLRPQSASTAHSTPSVPSPVSKSTLQGSVTPKH 1260
Query: 1261 IVSSFERPPRPLKATFMSSVKGSSHVRF 1288
IVSSFERPPRPLKATFMSSVKGSSHVRF
Sbjct: 1261 IVSSFERPPRPLKATFMSSVKGSSHVRF 1288
>gi|30520335 WD repeat domain 49 [Homo sapiens]
Length = 697
Score = 145 bits (367), Expect = 2e-34
Identities = 102/318 (32%), Positives = 153/318 (48%), Gaps = 17/318 (5%)
Query: 357 KASKKPRLSVLRLRKGILCFDYCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSV 416
K+ K+ ++ + +GI FDY N + T G + + LWNP+V +PV ++ GH SV
Sbjct: 6 KSKKRLNMTSFNIAQGIHAFDYHSRLNLIATAGINNKVCLWNPYVVSKPVGVLWGHSASV 65
Query: 417 --THILVDSRNNSILISVSKDKNIRVWDMLDYICLQSFCGKFFALGNCPITSAYFFEKDN 474
V+ + L S SKDK +R+WD+ + +Q F + +
Sbjct: 66 IAVQFFVERKQ---LFSFSKDKVLRLWDIQHQLSIQRIACSFPKSQDFRCLFHFDEAHGR 122
Query: 475 TLICSTYSIGILKGYLEAQGLIKARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEV 534
I + +L EA +K+ ++ C VLY+ I KQV+S TVS W +
Sbjct: 123 LFISFNNQLALLAMKSEASKRVKSHEKAVTC-----VLYNSILKQVISSDTGSTVSFWMI 177
Query: 535 VTGRKTMEFAVSGGQHVEMTAMALDESERCLLTGLRDGTMKMWNYNIGKC--LLTFPSPE 592
TG+K +F G + E++ MALD +E LLTG DGT+K+W++N G C L
Sbjct: 178 DTGQKIKQFTGCHG-NAEISTMALDANETRLLTGSTDGTVKIWDFN-GYCHHTLNVGQDG 235
Query: 593 QLEISGIIHMNKVFYVTGWSKRITHFLFHKTKPVLL-CYHWQ--TYHTEDILSMAKYRNQ 649
++IS I+ + K VTGW + IT F + W+ H +DIL A Q
Sbjct: 236 AVDISQILILKKKILVTGWERAITVFRPQNFNQFFIQPEEWKGGIQHHDDILCAAFLPPQ 295
Query: 650 FLGTSSYSGDILFWNTGT 667
L T SY G+I+ WN T
Sbjct: 296 TLVTGSYDGEIVLWNNST 313
Score = 50.1 bits (118), Expect = 1e-05
Identities = 30/87 (34%), Positives = 49/87 (56%), Gaps = 6/87 (6%)
Query: 801 SVEKIIFLQTRPRLPHT--AALLSSCMDGYIYAWSLHENGGLLGKFPVDLDNGDVVVGAM 858
+V ++ FL+ R T A L+S GY+ W +++ LL +F G ++ M
Sbjct: 371 AVMRLCFLKARKNTAVTGGANLVSCGGSGYVRFWDIYKKQ-LLAEFLAHSGVGSII---M 426
Query: 859 ATDKNDWILITGDCKGYIKIWDIKDYC 885
+TDK + L TGD G++KIW+I++YC
Sbjct: 427 STDKMNRYLTTGDLDGWLKIWNIEEYC 453
Score = 38.5 bits (88), Expect = 0.042
Identities = 15/36 (41%), Positives = 21/36 (58%)
Query: 850 NGDVVVGAMATDKNDWILITGDCKGYIKIWDIKDYC 885
+G+ + MA D N+ L+TG G +KIWD YC
Sbjct: 190 HGNAEISTMALDANETRLLTGSTDGTVKIWDFNGYC 225
>gi|115495443 WD repeat domain 64 [Homo sapiens]
Length = 634
Score = 119 bits (299), Expect = 1e-26
Identities = 79/264 (29%), Positives = 131/264 (49%), Gaps = 8/264 (3%)
Query: 328 QVKFIPQMNVVVSCSAIEKSSLVLTILPAKASKKPRLSVLRLRKGILCFDYCPDRNFLVT 387
++++I +N SCS SLVL L P + + +G F YC N +VT
Sbjct: 2 KIRYISALNCFGSCSLDSNHSLVLESLKRLEDNLP-VREFSMPRGANTFCYCVKANVIVT 60
Query: 388 GGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILISVSKDKNIRVWDMLDYI 447
GG D IRLW+P +S +PV + GH S+ I+ + ++ + +S+S K RVWD+
Sbjct: 61 GGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHV-VSLSSAKVFRVWDIQTLS 119
Query: 448 CLQSFCGKFFALGNCPITSAYFFEKDNTLICSTYSIGILKGYLEAQGLIKARKRT--THC 505
LQ F G+ I S + LI + ++ Y + +I+ K+ TH
Sbjct: 120 LLQVFHDSQGGPGDMQIYSMIYDANHGMLITGS---SVMDMYPLTR-MIQDTKQVPHTHE 175
Query: 506 SPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGRKTMEFAVSGGQHVEMTAMALDESERCL 565
+ +LY+K F QV++ C + VWE+ TG + + G + E+T+ A+DES
Sbjct: 176 REINVMLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHGFNTEVTSAAVDESGFLF 235
Query: 566 LTGLRDGTMKMWNYNIGKCLLTFP 589
TG +GT+++W++ G+ + P
Sbjct: 236 ATGAYNGTVRIWDFGSGQEMKVLP 259
Score = 37.0 bits (84), Expect = 0.12
Identities = 16/47 (34%), Positives = 28/47 (59%), Gaps = 1/47 (2%)
Query: 945 LMTWKGHLNSVADILYVDNFQLVISAGQDRDVKAW-KLSGDAIGTFG 990
L++W+ H + ++YV+ Q+V++A D V+ W L+G G FG
Sbjct: 413 LLSWRAHSLEIIQVIYVEEKQVVLTASIDGSVRLWHALNGHYCGYFG 459
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 70.9 bits (172), Expect = 8e-12
Identities = 49/236 (20%), Positives = 107/236 (45%), Gaps = 15/236 (6%)
Query: 355 PAKASKKPRLSVLRLRKGILCFDYCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQT 414
P K + + ++ K + + P+ +L + D I++W + K + GH+
Sbjct: 30 PVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI-SGHKL 88
Query: 415 SVTHILVDSRNNSILISVSKDKNIRVWDMLDYICLQSFCGKFFALGNCPITSAYFFEKDN 474
++ + S +N +L+S S DK +++WD+ CL++ G + C F + N
Sbjct: 89 GISDVAWSSDSN-LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCN-----FNPQSN 142
Query: 475 TLICSTYSIGILKGYLEAQGLIKARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEV 534
++ ++ + ++ +K H P+ AV +++ +VS G +W+
Sbjct: 143 LIVSGSFDESVRIWDVKTGKCLKTLP--AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200
Query: 535 VTGR--KTMEFAVSGGQHVEMTAMALDESERCLLTGLRDGTMKMWNYNIGKCLLTF 588
+G+ KT+ + ++ + + + +L D T+K+W+Y+ GKCL T+
Sbjct: 201 ASGQCLKTL----IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY 252
Score = 38.9 bits (89), Expect = 0.032
Identities = 35/155 (22%), Positives = 62/155 (40%), Gaps = 24/155 (15%)
Query: 322 HPNWCEQVKFIPQMNVVVSCSAIE-------KSSLVLTILPAKASKKPRLSVLRLRKGIL 374
H N+ F PQ N++VS S E K+ L LPA + + R
Sbjct: 128 HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNR------ 181
Query: 375 CFDYCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILISVSK 434
D + +V+ YD R+W+ + L+ V+ + S N +++ +
Sbjct: 182 ------DGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKF-SPNGKYILAATL 234
Query: 435 DKNIRVWDMLDYICLQSFCG----KFFALGNCPIT 465
D +++WD CL+++ G K+ N +T
Sbjct: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVT 269
Score = 35.0 bits (79), Expect = 0.46
Identities = 29/138 (21%), Positives = 62/138 (44%), Gaps = 8/138 (5%)
Query: 455 KFFALGNCPITSAYFFEKDNTLICSTYSIGILKGYLEAQGLIKARKRTTHCSPLCAVLYS 514
KF G+ S+ F + + S+ + ++K + G + + + H + V +S
Sbjct: 38 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE-KTISGHKLGISDVAWS 96
Query: 515 KIFKQVVSGCLRGTVSVWEVVTGR--KTMEFAVSGGQHVEMTAMALDESERCLLTGLRDG 572
+VS T+ +W+V +G+ KT++ G + + +++G D
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLK-----GHSNYVFCCNFNPQSNLIVSGSFDE 151
Query: 573 TMKMWNYNIGKCLLTFPS 590
++++W+ GKCL T P+
Sbjct: 152 SVRIWDVKTGKCLKTLPA 169
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 70.9 bits (172), Expect = 8e-12
Identities = 49/236 (20%), Positives = 107/236 (45%), Gaps = 15/236 (6%)
Query: 355 PAKASKKPRLSVLRLRKGILCFDYCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQT 414
P K + + ++ K + + P+ +L + D I++W + K + GH+
Sbjct: 30 PVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI-SGHKL 88
Query: 415 SVTHILVDSRNNSILISVSKDKNIRVWDMLDYICLQSFCGKFFALGNCPITSAYFFEKDN 474
++ + S +N +L+S S DK +++WD+ CL++ G + C F + N
Sbjct: 89 GISDVAWSSDSN-LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCN-----FNPQSN 142
Query: 475 TLICSTYSIGILKGYLEAQGLIKARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEV 534
++ ++ + ++ +K H P+ AV +++ +VS G +W+
Sbjct: 143 LIVSGSFDESVRIWDVKTGKCLKTLP--AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200
Query: 535 VTGR--KTMEFAVSGGQHVEMTAMALDESERCLLTGLRDGTMKMWNYNIGKCLLTF 588
+G+ KT+ + ++ + + + +L D T+K+W+Y+ GKCL T+
Sbjct: 201 ASGQCLKTL----IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY 252
Score = 38.9 bits (89), Expect = 0.032
Identities = 35/155 (22%), Positives = 62/155 (40%), Gaps = 24/155 (15%)
Query: 322 HPNWCEQVKFIPQMNVVVSCSAIE-------KSSLVLTILPAKASKKPRLSVLRLRKGIL 374
H N+ F PQ N++VS S E K+ L LPA + + R
Sbjct: 128 HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNR------ 181
Query: 375 CFDYCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILISVSK 434
D + +V+ YD R+W+ + L+ V+ + S N +++ +
Sbjct: 182 ------DGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKF-SPNGKYILAATL 234
Query: 435 DKNIRVWDMLDYICLQSFCG----KFFALGNCPIT 465
D +++WD CL+++ G K+ N +T
Sbjct: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVT 269
Score = 35.0 bits (79), Expect = 0.46
Identities = 29/138 (21%), Positives = 62/138 (44%), Gaps = 8/138 (5%)
Query: 455 KFFALGNCPITSAYFFEKDNTLICSTYSIGILKGYLEAQGLIKARKRTTHCSPLCAVLYS 514
KF G+ S+ F + + S+ + ++K + G + + + H + V +S
Sbjct: 38 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE-KTISGHKLGISDVAWS 96
Query: 515 KIFKQVVSGCLRGTVSVWEVVTGR--KTMEFAVSGGQHVEMTAMALDESERCLLTGLRDG 572
+VS T+ +W+V +G+ KT++ G + + +++G D
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLK-----GHSNYVFCCNFNPQSNLIVSGSFDE 151
Query: 573 TMKMWNYNIGKCLLTFPS 590
++++W+ GKCL T P+
Sbjct: 152 SVRIWDVKTGKCLKTLPA 169
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 66.2 bits (160), Expect = 2e-10
Identities = 48/211 (22%), Positives = 93/211 (44%), Gaps = 11/211 (5%)
Query: 378 YCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILISVSKDKN 437
+ P+ +L + D I +W + K L GH ++ + S ++S L+S S DK
Sbjct: 49 FSPNGEWLASSSADRLIIIWGAYDGKYEKTLY-GHNLEISDVAWSS-DSSRLVSASDDKT 106
Query: 438 IRVWDMLDYICLQSFCGKFFALGNCPITSAYFFEKDNTLICSTYSIGILKGYLEAQGLIK 497
+++WD+ CL++ G + C F N +I ++ + ++ +K
Sbjct: 107 LKLWDVRSGKCLKTLKGHSNYVFCCN-----FNPPSNLIISGSFDETVKIWEVKTGKCLK 161
Query: 498 ARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGRKTMEFAVSGGQHVEMTAMA 557
+ H P+ AV ++ +VSG G +W+ +G+ V +
Sbjct: 162 TL--SAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFS 219
Query: 558 LDESERCLLTGLRDGTMKMWNYNIGKCLLTF 588
+ + +LT D T+K+W+Y+ G+CL T+
Sbjct: 220 --PNGKYILTATLDNTLKLWDYSRGRCLKTY 248
Score = 43.9 bits (102), Expect = 0.001
Identities = 53/220 (24%), Positives = 91/220 (41%), Gaps = 30/220 (13%)
Query: 373 ILCFDYCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILISV 432
+ C ++ P N +++G +D +++W K + + H V+ + + + S+++S
Sbjct: 128 VFCCNFNPPSNLIISGSFDETVKIWEVKTGK-CLKTLSAHSDPVSAVHFNC-SGSLIVSG 185
Query: 433 SKDKNIRVWDMLDYICLQSFCG---------KFFALGNCPITSAYFFEKDNTLICSTYSI 483
S D R+WD CL++ KF G +T+ DNTL YS
Sbjct: 186 SYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATL----DNTLKLWDYSR 241
Query: 484 G-ILKGYLEAQGLIKARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGRKTME 542
G LK Y K +C + A K +VSG V +W + T K +
Sbjct: 242 GRCLKTY-------TGHKNEKYC--IFANFSVTGGKWIVSGSEDNLVYIWNLQT--KEIV 290
Query: 543 FAVSGGQHVEMTAMALDESERCLLTGL--RDGTMKMWNYN 580
+ G V ++A A +E + + D T+K+W N
Sbjct: 291 QKLQGHTDVVISA-ACHPTENLIASAALENDKTIKLWMSN 329
>gi|18874090 WD repeat domain 48 [Homo sapiens]
Length = 677
Score = 63.5 bits (153), Expect = 1e-09
Identities = 49/228 (21%), Positives = 93/228 (40%), Gaps = 18/228 (7%)
Query: 370 RKGILCFDYCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMK-GHQTSVTHILVDSRNNSI 428
R G+ P N L T G D+ IR+W+ K+ ++ H T + +V N
Sbjct: 30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKT 89
Query: 429 LISVSKDKNIRVWDMLDYICLQSFCGKFFALGNCPITSAYFFEKDNTLICST-------- 480
LIS S D ++VW+ C+ + + A + KD L+ S
Sbjct: 90 LISASSDTTVKVWNAHKGFCMSTL------RTHKDYVKALAYAKDKELVASAGLDRQIFL 143
Query: 481 YSIGILKGYLEAQGLIKARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGRKT 540
+ + L + + + + + ++ +++ +VSG + VW+ T K
Sbjct: 144 WDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKL 203
Query: 541 MEFAVSGGQHVEMTAMALDESERCLLTGLRDGTMKMWNYNIGKCLLTF 588
M+ G + A+ L+ L+G DGT+++W+ +C+ T+
Sbjct: 204 MKLK---GHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATY 248
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 62.8 bits (151), Expect = 2e-09
Identities = 47/207 (22%), Positives = 93/207 (44%), Gaps = 13/207 (6%)
Query: 373 ILCFDYCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILISV 432
+ C + P+ + L + G+D I LWN + +KGH +V + ++ + S+L S
Sbjct: 69 VYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNT-DGSMLFSA 127
Query: 433 SKDKNIRVWDMLDYICLQSFCGKFFALGNCPITSAYFFEKDNTLICSTYSIGILKGY-LE 491
S DK + VWD ++ G + +C Y + L+C+ G +K + +
Sbjct: 128 STDKTVAVWDSETGERVKRLKGHTSFVNSC-----YPARRGPQLVCTGSDDGTVKLWDIR 182
Query: 492 AQGLIKARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGRKTMEFAVSGGQHV 551
+ I+ + T + AV ++ Q++SG + + VW++ + T G
Sbjct: 183 KKAAIQTFQNTYQ---VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMR---GHAD 236
Query: 552 EMTAMALDESERCLLTGLRDGTMKMWN 578
+T ++L LL+ D T+++W+
Sbjct: 237 SVTGLSLSSEGSYLLSNAMDNTVRVWD 263
Score = 42.7 bits (99), Expect = 0.002
Identities = 36/120 (30%), Positives = 59/120 (49%), Gaps = 10/120 (8%)
Query: 360 KKPRLSVLRLRKGILCFDYCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHI 419
KK + + +L + + +++GG D I++W+ +K + M+GH SVT +
Sbjct: 183 KKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKL-TYTMRGHADSVTGL 241
Query: 420 LVDSRNNSILISVSKDKNIRVWDMLDYICLQSFCGKFFALGNCPITSAYFFEKDNTLICS 479
+ S S L+S + D +RVWD+ + + C K F GN + FEK N L CS
Sbjct: 242 SLSSEG-SYLLSNAMDNTVRVWDVRPF-APKERCVKIFQ-GN-----VHNFEK-NLLRCS 292
Score = 36.2 bits (82), Expect = 0.21
Identities = 20/74 (27%), Positives = 37/74 (50%), Gaps = 2/74 (2%)
Query: 365 SVLRLRKGILCFDYCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSR 424
+V K +L + PD + + G D F+ +W+ S+R ++ + GH S+ +
Sbjct: 280 NVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDT-TSRRILYKLPGHAGSINEVAFHP- 337
Query: 425 NNSILISVSKDKNI 438
+ I+IS S DK +
Sbjct: 338 DEPIIISASSDKRL 351
Score = 30.8 bits (68), Expect = 8.7
Identities = 20/91 (21%), Positives = 37/91 (40%), Gaps = 2/91 (2%)
Query: 504 HCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGRKTMEFAVSGGQHVEMTAMALDESER 563
H + + Y+ + S TV+VW+ TG + + G + +
Sbjct: 108 HSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKR--LKGHTSFVNSCYPARRGPQ 165
Query: 564 CLLTGLRDGTMKMWNYNIGKCLLTFPSPEQL 594
+ TG DGT+K+W+ + TF + Q+
Sbjct: 166 LVCTGSDDGTVKLWDIRKKAAIQTFQNTYQV 196
>gi|157266266 WD repeat domain 86 [Homo sapiens]
Length = 376
Score = 61.2 bits (147), Expect = 6e-09
Identities = 79/363 (21%), Positives = 135/363 (37%), Gaps = 69/363 (19%)
Query: 370 RKGILCFDYCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSIL 429
R GI PD L+TG D RLW+ + L++GH++ VT ++ +
Sbjct: 15 RGGINWLSLSPDGQRLLTGSEDGTARLWST-ADGQCCALLQGHESYVTFCQLE---DEAA 70
Query: 430 ISVSKDKNIRVWDMLDYICLQSFCG----------------------------------- 454
+ S D IR WD+L CLQ + G
Sbjct: 71 FTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKGQMS 130
Query: 455 -KFFALGNCPITSAYFFEKD------------NTLICSTYSIGILKGYLEAQGLIKARKR 501
+F NC +T AY D L+ + + G K + A G R
Sbjct: 131 REFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLR 190
Query: 502 TTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGRKTMEFAVSGGQHVEMTAMALDES 561
+ LC VL + +G T+ W++++G + F G + + L+
Sbjct: 191 GHTGAVLCLVLDTP-GHTAFTGSTDATIRAWDILSGEQLRVFREHRG-----SVICLELV 244
Query: 562 ERCLLTGLRDGTMKMWNYNIGKCLLTFPSPEQLEISGIIHMNKVFYVTGWSKRITHFLFH 621
R + +G D T+K W + G+C+ TF + + + H +F TG
Sbjct: 245 NRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLF--TGSGDACARAFDA 302
Query: 622 KTKPVLLCYHWQTYHTEDILSMAKYRNQFLGTSSYSGDILFWNTGTLKPIFNFNASRSPS 681
++ + + T+ I++ + Q L T+S+ G + W+ L+ A R P
Sbjct: 303 QSGELRRVFRGHTF----IINCIQVHGQVLYTASHDGALRLWDVRGLR-----GAPRPPP 353
Query: 682 PLQ 684
P++
Sbjct: 354 PMR 356
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 59.7 bits (143), Expect = 2e-08
Identities = 47/202 (23%), Positives = 90/202 (44%), Gaps = 11/202 (5%)
Query: 386 VTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILISVSKDKNIRVWDMLD 445
+TG YD +LW+ S + ++GH+ V I ++ + + S DK ++W +
Sbjct: 108 ITGSYDRTCKLWDT-ASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVET 166
Query: 446 YICLQSFCGKFFALGNCPITSAYFFEKDNTLICSTYSIGILKGYLEAQGLIKARKRTTHC 505
C +F G + F +TL+ +T S+ + Q + H
Sbjct: 167 GKCYHTFRGHTAEI------VCLSFNPQSTLV-ATGSMDTTAKLWDIQNGEEVYTLRGHS 219
Query: 506 SPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGRKTMEFAVSGGQHVEMTAMALDESERCL 565
+ + ++ ++ ++++G TV VW+ TGRK + G E+++ + + +
Sbjct: 220 AEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVN---ILIGHCAEISSASFNWDCSLI 276
Query: 566 LTGLRDGTMKMWNYNIGKCLLT 587
LTG D T K+W+ GKC+ T
Sbjct: 277 LTGSMDKTCKLWDATNGKCVAT 298
Score = 51.6 bits (122), Expect = 5e-06
Identities = 49/213 (23%), Positives = 88/213 (41%), Gaps = 12/213 (5%)
Query: 373 ILCFDYCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILISV 432
I+C + P + TG D +LW+ + V+ ++GH + + ++ + I I+
Sbjct: 180 IVCLSFNPQSTLVATGSMDTTAKLWD-IQNGEEVYTLRGHSAEIISLSFNTSGDRI-ITG 237
Query: 433 SKDKNIRVWDMLDYICLQSFCGKFFALGNCPITSAYFFEKDNTLICSTYSIGILKGYLEA 492
S D + VWD + +G+C S+ F D +LI + K +
Sbjct: 238 SFDHTVVVWDA------DTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDAT 291
Query: 493 QGLIKARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGRKTMEFAVSGGQHVE 552
G A T H + + K + + GT ++ T RK + A G E
Sbjct: 292 NGKCVATL-TGHDDEILDSCFDYTGKLIATASADGTARIFSAAT-RKCI--AKLEGHEGE 347
Query: 553 MTAMALDESERCLLTGLRDGTMKMWNYNIGKCL 585
++ ++ + LLTG D T ++W+ G+CL
Sbjct: 348 ISKISFNPQGNHLLTGSSDKTARIWDAQTGQCL 380
Score = 43.1 bits (100), Expect = 0.002
Identities = 43/205 (20%), Positives = 91/205 (44%), Gaps = 16/205 (7%)
Query: 374 LCFDYCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILISVS 433
L F+ DR ++TG +D + +W+ ++ V ++ GH ++ + + S++++ S
Sbjct: 225 LSFNTSGDR--IITGSFDHTVVVWDADTGRK-VNILIGHCAEISSASFNW-DCSLILTGS 280
Query: 434 KDKNIRVWDMLDYICLQSFCGKFFA-LGNCPITSAYFFEKDNTLICSTYSIGILKGYLEA 492
DK ++WD + C+ + G L +C F+ LI + + G + + A
Sbjct: 281 MDKTCKLWDATNGKCVATLTGHDDEILDSC-------FDYTGKLIATASADGTARIFSAA 333
Query: 493 QGLIKARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGRKTMEFAVSGGQHVE 552
A K H + + ++ +++G T +W+ TG+ V G E
Sbjct: 334 TRKCIA-KLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQ---VLEGHTDE 389
Query: 553 MTAMALDESERCLLTGLRDGTMKMW 577
+ + A + ++TG +D T ++W
Sbjct: 390 IFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 34.3 bits (77), Expect = 0.79
Identities = 32/131 (24%), Positives = 54/131 (41%), Gaps = 19/131 (14%)
Query: 543 FAVSGGQHVEMTAMALDESERCLLTGLRDGTMKMWNYNIGKCLLTFPSPEQLEISGIIHM 602
F V + +T +AL++S C +TG D T K+W+ G+ L T H
Sbjct: 85 FKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEG----------HR 134
Query: 603 NKVFYV---TGWSKRITHFLFHKTKPVL-----LCYHWQTYHTEDILSMA-KYRNQFLGT 653
N V+ + + +I F KT + CYH HT +I+ ++ ++ + T
Sbjct: 135 NVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVAT 194
Query: 654 SSYSGDILFWN 664
S W+
Sbjct: 195 GSMDTTAKLWD 205
>gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo
sapiens]
Length = 504
Score = 59.3 bits (142), Expect = 2e-08
Identities = 55/232 (23%), Positives = 96/232 (41%), Gaps = 15/232 (6%)
Query: 372 GILCFDYCP-DRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILI 430
GIL D CP D N ++TGG D + +++ S++ + +KGH VT ++ + ++
Sbjct: 223 GILALDLCPSDTNKILTGGADKNVVVFDKS-SEQILATLKGHTKKVTSVVFHP-SQDLVF 280
Query: 431 SVSKDKNIRVWDMLDYICLQSFCGKFFALGNCPITSAYFFEKDNTLICSTYSIGILKGYL 490
S S D IR+W + + C+Q A+ + + D L S
Sbjct: 281 SASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHAT----GDYLLSSSDDQYWAFSDIQ 336
Query: 491 EAQGLIKARKRTTHCSPLCAVLY--SKIFKQVVSGCLRGTVSVWEVVTGRKTMEFAVSGG 548
+ L K T+ CS CA + IF +G + + +W++ F G
Sbjct: 337 TGRVLTKVTDETSGCSLTCAQFHPDGLIFG---TGTMDSQIKIWDLKERTNVANFP---G 390
Query: 549 QHVEMTAMALDESERCLLTGLRDGTMKMWNYNIGKCLLTFPSPEQLEISGII 600
+T++A E+ L T D ++K+W+ K T E+ +I
Sbjct: 391 HSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLI 442
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 57.8 bits (138), Expect = 7e-08
Identities = 55/234 (23%), Positives = 106/234 (45%), Gaps = 33/234 (14%)
Query: 383 NFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILISVSKDKNIRVWD 442
N +++G D +++WN + + + GH ++V + + + ++S S+D +RVWD
Sbjct: 314 NIIISGSTDRTLKVWNAETGEC-IHTLYGHTSTVRCMHLHEKR---VVSGSRDATLRVWD 369
Query: 443 MLDYICLQSFCGKFFAL------GNCPITSAYFFEKDNTLICSTYSIGILKGYLEAQGLI 496
+ CL G A+ G ++ AY F + + L+G
Sbjct: 370 IETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQG-------- 421
Query: 497 KARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGRKTMEFAVSGGQHVEMTAM 556
H + + ++ + I VVSG L ++ VW+V TG ++G H +T+
Sbjct: 422 -------HTNRVYSLQFDGI--HVVSGSLDTSIRVWDVETGNCI--HTLTG--HQSLTS- 467
Query: 557 ALDESERCLLTGLRDGTMKMWNYNIGKCLLTFPSPEQLEIS-GIIHMNKVFYVT 609
++ + L++G D T+K+W+ G+CL T P + + + + NK F +T
Sbjct: 468 GMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVIT 521
Score = 51.6 bits (122), Expect = 5e-06
Identities = 53/207 (25%), Positives = 94/207 (45%), Gaps = 24/207 (11%)
Query: 373 ILCFDYCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILISV 432
+ C Y D +V+G YD +++W+P ++ + ++GH V + D + ++S
Sbjct: 386 VRCVQY--DGRRVVSGAYDFMVKVWDP-ETETCLHTLQGHTNRVYSLQFDGIH---VVSG 439
Query: 433 SKDKNIRVWDMLDYICLQSFCGKFFALGNCPITSAYFFEKDNTLIC----STYSIGILKG 488
S D +IRVWD+ C+ + G+ +TS KDN L+ ST I +K
Sbjct: 440 SLDTSIRVWDVETGNCIHTL------TGHQSLTSGMEL-KDNILVSGNADSTVKIWDIK- 491
Query: 489 YLEAQGLIKARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGR--KTMEFAVS 546
Q L + H S + + ++K F V++ GTV +W++ TG + + S
Sbjct: 492 --TGQCLQTLQGPNKHQSAVTCLQFNKNF--VITSSDDGTVKLWDLKTGEFIRNLVTLES 547
Query: 547 GGQHVEMTAMALDESERCLLTGLRDGT 573
GG + + ++ G R+GT
Sbjct: 548 GGSGGVVWRIRASNTKLVCAVGSRNGT 574
Score = 39.7 bits (91), Expect = 0.019
Identities = 61/295 (20%), Positives = 112/295 (37%), Gaps = 51/295 (17%)
Query: 408 LMKGHQTSVTHILVDSRNNSILISVSKDKNIRVWDMLDYICLQSFCGKFFALGNCPITSA 467
++KGH V L N ++S S D ++VW + CL++ G + + +
Sbjct: 257 VLKGHDDHVITCLQFCGNR--IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--- 311
Query: 468 YFFEKDNTLICSTYSIGILKGYLEAQGLIKARKRTTHCSPLCAVLYSKIFKQVVSGCLRG 527
+DN +I + + E I T + C L+ K +VVSG
Sbjct: 312 ----RDNIIISGSTDRTLKVWNAETGECIHTLYGHTS-TVRCMHLHEK---RVVSGSRDA 363
Query: 528 TVSVWEVVTGR------------KTMEF---AVSGGQHVEMTAMALDESERCL------- 565
T+ VW++ TG+ + +++ V G + M + E+E CL
Sbjct: 364 TLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHT 423
Query: 566 -------------LTGLRDGTMKMWNYNIGKCLLTFPSPEQLEISGIIHMNKVFYVTGWS 612
++G D ++++W+ G C+ T + L SG + + V+G +
Sbjct: 424 NRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSL-TSG-MELKDNILVSGNA 481
Query: 613 KRITHFLFHKTKPVLLCYHWQTYHTEDILSMAKYRNQFLGTSSYSGDILFWNTGT 667
KT L H + ++ ++ F+ TSS G + W+ T
Sbjct: 482 DSTVKIWDIKTGQCLQTLQGPNKH-QSAVTCLQFNKNFVITSSDDGTVKLWDLKT 535
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 57.8 bits (138), Expect = 7e-08
Identities = 55/234 (23%), Positives = 106/234 (45%), Gaps = 33/234 (14%)
Query: 383 NFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILISVSKDKNIRVWD 442
N +++G D +++WN + + + GH ++V + + + ++S S+D +RVWD
Sbjct: 432 NIIISGSTDRTLKVWNAETGEC-IHTLYGHTSTVRCMHLHEKR---VVSGSRDATLRVWD 487
Query: 443 MLDYICLQSFCGKFFAL------GNCPITSAYFFEKDNTLICSTYSIGILKGYLEAQGLI 496
+ CL G A+ G ++ AY F + + L+G
Sbjct: 488 IETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQG-------- 539
Query: 497 KARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGRKTMEFAVSGGQHVEMTAM 556
H + + ++ + I VVSG L ++ VW+V TG ++G H +T+
Sbjct: 540 -------HTNRVYSLQFDGI--HVVSGSLDTSIRVWDVETGNCI--HTLTG--HQSLTS- 585
Query: 557 ALDESERCLLTGLRDGTMKMWNYNIGKCLLTFPSPEQLEIS-GIIHMNKVFYVT 609
++ + L++G D T+K+W+ G+CL T P + + + + NK F +T
Sbjct: 586 GMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVIT 639
Score = 51.6 bits (122), Expect = 5e-06
Identities = 53/207 (25%), Positives = 94/207 (45%), Gaps = 24/207 (11%)
Query: 373 ILCFDYCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILISV 432
+ C Y D +V+G YD +++W+P ++ + ++GH V + D + ++S
Sbjct: 504 VRCVQY--DGRRVVSGAYDFMVKVWDP-ETETCLHTLQGHTNRVYSLQFDGIH---VVSG 557
Query: 433 SKDKNIRVWDMLDYICLQSFCGKFFALGNCPITSAYFFEKDNTLIC----STYSIGILKG 488
S D +IRVWD+ C+ + G+ +TS KDN L+ ST I +K
Sbjct: 558 SLDTSIRVWDVETGNCIHTL------TGHQSLTSGMEL-KDNILVSGNADSTVKIWDIK- 609
Query: 489 YLEAQGLIKARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGR--KTMEFAVS 546
Q L + H S + + ++K F V++ GTV +W++ TG + + S
Sbjct: 610 --TGQCLQTLQGPNKHQSAVTCLQFNKNF--VITSSDDGTVKLWDLKTGEFIRNLVTLES 665
Query: 547 GGQHVEMTAMALDESERCLLTGLRDGT 573
GG + + ++ G R+GT
Sbjct: 666 GGSGGVVWRIRASNTKLVCAVGSRNGT 692
Score = 39.7 bits (91), Expect = 0.019
Identities = 61/295 (20%), Positives = 112/295 (37%), Gaps = 51/295 (17%)
Query: 408 LMKGHQTSVTHILVDSRNNSILISVSKDKNIRVWDMLDYICLQSFCGKFFALGNCPITSA 467
++KGH V L N ++S S D ++VW + CL++ G + + +
Sbjct: 375 VLKGHDDHVITCLQFCGNR--IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--- 429
Query: 468 YFFEKDNTLICSTYSIGILKGYLEAQGLIKARKRTTHCSPLCAVLYSKIFKQVVSGCLRG 527
+DN +I + + E I T + C L+ K +VVSG
Sbjct: 430 ----RDNIIISGSTDRTLKVWNAETGECIHTLYGHTS-TVRCMHLHEK---RVVSGSRDA 481
Query: 528 TVSVWEVVTGR------------KTMEF---AVSGGQHVEMTAMALDESERCL------- 565
T+ VW++ TG+ + +++ V G + M + E+E CL
Sbjct: 482 TLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHT 541
Query: 566 -------------LTGLRDGTMKMWNYNIGKCLLTFPSPEQLEISGIIHMNKVFYVTGWS 612
++G D ++++W+ G C+ T + L SG + + V+G +
Sbjct: 542 NRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSL-TSG-MELKDNILVSGNA 599
Query: 613 KRITHFLFHKTKPVLLCYHWQTYHTEDILSMAKYRNQFLGTSSYSGDILFWNTGT 667
KT L H + ++ ++ F+ TSS G + W+ T
Sbjct: 600 DSTVKIWDIKTGQCLQTLQGPNKH-QSAVTCLQFNKNFVITSSDDGTVKLWDLKT 653
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 57.8 bits (138), Expect = 7e-08
Identities = 55/234 (23%), Positives = 106/234 (45%), Gaps = 33/234 (14%)
Query: 383 NFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILISVSKDKNIRVWD 442
N +++G D +++WN + + + GH ++V + + + ++S S+D +RVWD
Sbjct: 352 NIIISGSTDRTLKVWNAETGEC-IHTLYGHTSTVRCMHLHEKR---VVSGSRDATLRVWD 407
Query: 443 MLDYICLQSFCGKFFAL------GNCPITSAYFFEKDNTLICSTYSIGILKGYLEAQGLI 496
+ CL G A+ G ++ AY F + + L+G
Sbjct: 408 IETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQG-------- 459
Query: 497 KARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGRKTMEFAVSGGQHVEMTAM 556
H + + ++ + I VVSG L ++ VW+V TG ++G H +T+
Sbjct: 460 -------HTNRVYSLQFDGI--HVVSGSLDTSIRVWDVETGNCI--HTLTG--HQSLTS- 505
Query: 557 ALDESERCLLTGLRDGTMKMWNYNIGKCLLTFPSPEQLEIS-GIIHMNKVFYVT 609
++ + L++G D T+K+W+ G+CL T P + + + + NK F +T
Sbjct: 506 GMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVIT 559
Score = 51.6 bits (122), Expect = 5e-06
Identities = 53/207 (25%), Positives = 94/207 (45%), Gaps = 24/207 (11%)
Query: 373 ILCFDYCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILISV 432
+ C Y D +V+G YD +++W+P ++ + ++GH V + D + ++S
Sbjct: 424 VRCVQY--DGRRVVSGAYDFMVKVWDP-ETETCLHTLQGHTNRVYSLQFDGIH---VVSG 477
Query: 433 SKDKNIRVWDMLDYICLQSFCGKFFALGNCPITSAYFFEKDNTLIC----STYSIGILKG 488
S D +IRVWD+ C+ + G+ +TS KDN L+ ST I +K
Sbjct: 478 SLDTSIRVWDVETGNCIHTL------TGHQSLTSGMEL-KDNILVSGNADSTVKIWDIK- 529
Query: 489 YLEAQGLIKARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGR--KTMEFAVS 546
Q L + H S + + ++K F V++ GTV +W++ TG + + S
Sbjct: 530 --TGQCLQTLQGPNKHQSAVTCLQFNKNF--VITSSDDGTVKLWDLKTGEFIRNLVTLES 585
Query: 547 GGQHVEMTAMALDESERCLLTGLRDGT 573
GG + + ++ G R+GT
Sbjct: 586 GGSGGVVWRIRASNTKLVCAVGSRNGT 612
Score = 39.7 bits (91), Expect = 0.019
Identities = 61/295 (20%), Positives = 112/295 (37%), Gaps = 51/295 (17%)
Query: 408 LMKGHQTSVTHILVDSRNNSILISVSKDKNIRVWDMLDYICLQSFCGKFFALGNCPITSA 467
++KGH V L N ++S S D ++VW + CL++ G + + +
Sbjct: 295 VLKGHDDHVITCLQFCGNR--IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--- 349
Query: 468 YFFEKDNTLICSTYSIGILKGYLEAQGLIKARKRTTHCSPLCAVLYSKIFKQVVSGCLRG 527
+DN +I + + E I T + C L+ K +VVSG
Sbjct: 350 ----RDNIIISGSTDRTLKVWNAETGECIHTLYGHTS-TVRCMHLHEK---RVVSGSRDA 401
Query: 528 TVSVWEVVTGR------------KTMEF---AVSGGQHVEMTAMALDESERCL------- 565
T+ VW++ TG+ + +++ V G + M + E+E CL
Sbjct: 402 TLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHT 461
Query: 566 -------------LTGLRDGTMKMWNYNIGKCLLTFPSPEQLEISGIIHMNKVFYVTGWS 612
++G D ++++W+ G C+ T + L SG + + V+G +
Sbjct: 462 NRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSL-TSG-MELKDNILVSGNA 519
Query: 613 KRITHFLFHKTKPVLLCYHWQTYHTEDILSMAKYRNQFLGTSSYSGDILFWNTGT 667
KT L H + ++ ++ F+ TSS G + W+ T
Sbjct: 520 DSTVKIWDIKTGQCLQTLQGPNKH-QSAVTCLQFNKNFVITSSDDGTVKLWDLKT 573
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 55.8 bits (133), Expect = 3e-07
Identities = 75/324 (23%), Positives = 124/324 (38%), Gaps = 36/324 (11%)
Query: 371 KGILCFDYCPDRNFLVTGGYDAFIRLW--NPFVSKRPVWLMKGHQTSVTHILVDSRNNSI 428
KG+ C Y D +V+G D I++W N KR ++ GH SV + D R +
Sbjct: 268 KGVYCLQY--DDQKIVSGLRDNTIKIWDKNTLECKR---ILTGHTGSVLCLQYDER---V 319
Query: 429 LISVSKDKNIRVWDMLDYICLQSFCGKFFALGNCPITSAYFFEKDNTLICSTYSIGILKG 488
+I+ S D +RVWD+ L + + +C F + CS +
Sbjct: 320 IITGSSDSTVRVWDVNTGEMLNTL------IHHCEAVLHLRFNNGMMVTCSKDRSIAVWD 373
Query: 489 YLEAQGLIKARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGRKTMEFAVSGG 548
+ R H + + V + K +VS T+ VW T EF +
Sbjct: 374 MASPTDITLRRVLVGHRAAVNVVDFDD--KYIVSASGDRTIKVWNT----STCEFVRTLN 427
Query: 549 QHVEMTAMALDESERCLLTGLRDGTMKMWNYNIGKCLLTFPSPEQLEISGIIHMNKVFYV 608
H A L +R +++G D T+++W+ G CL E+L + I NK
Sbjct: 428 GHKRGIA-CLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEEL-VRCIRFDNKRIVS 485
Query: 609 TGWSKRITHF-----LFHKTKPVLLCYHWQTYHTEDILSMAKYRNQFLGTSSYSGDILFW 663
+ +I + L + LC H+ + + Q + +SS+ IL W
Sbjct: 486 GAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIV-SSSHDDTILIW 544
Query: 664 NTGTLKPIFNFNASRSPSPLQPKR 687
+ N A+++ P P R
Sbjct: 545 D------FLNDPAAQAEPPRSPSR 562
Score = 33.5 bits (75), Expect = 1.3
Identities = 51/219 (23%), Positives = 91/219 (41%), Gaps = 31/219 (14%)
Query: 326 CEQVKFIPQMN-VVVSCSAIEKSSLVLTILPAKASKKPRLSVLRLRKGILCFDYCPDRNF 384
CE V + N ++V+CS + S+ + + + R ++ R + D+ D +
Sbjct: 347 CEAVLHLRFNNGMMVTCS--KDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDF--DDKY 402
Query: 385 LVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILISVSKDKNIRVWDML 444
+V+ D I++WN + V + GH+ + + R +++S S D IR+WD+
Sbjct: 403 IVSASGDRTIKVWNTSTCEF-VRTLNGHKRGIACLQYRDR---LVVSGSSDNTIRLWDIE 458
Query: 445 DYICLQSFCGKFFALGNCPITSAYFFEKDNTLICSTYSIGILKGYLEAQGLIKARKRTTH 504
CL+ G L C DN I S G G ++ L+ A
Sbjct: 459 CGACLRVLEG-HEELVRC-------IRFDNKRIVS----GAYDGKIKVWDLVAALDPRAP 506
Query: 505 CSPLC---AVLYS-KIFK------QVVSGCLRGTVSVWE 533
LC V +S ++F+ Q+VS T+ +W+
Sbjct: 507 AGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWD 545
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 55.8 bits (133), Expect = 3e-07
Identities = 75/324 (23%), Positives = 124/324 (38%), Gaps = 36/324 (11%)
Query: 371 KGILCFDYCPDRNFLVTGGYDAFIRLW--NPFVSKRPVWLMKGHQTSVTHILVDSRNNSI 428
KG+ C Y D +V+G D I++W N KR ++ GH SV + D R +
Sbjct: 304 KGVYCLQY--DDQKIVSGLRDNTIKIWDKNTLECKR---ILTGHTGSVLCLQYDER---V 355
Query: 429 LISVSKDKNIRVWDMLDYICLQSFCGKFFALGNCPITSAYFFEKDNTLICSTYSIGILKG 488
+I+ S D +RVWD+ L + + +C F + CS +
Sbjct: 356 IITGSSDSTVRVWDVNTGEMLNTL------IHHCEAVLHLRFNNGMMVTCSKDRSIAVWD 409
Query: 489 YLEAQGLIKARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGRKTMEFAVSGG 548
+ R H + + V + K +VS T+ VW T EF +
Sbjct: 410 MASPTDITLRRVLVGHRAAVNVVDFDD--KYIVSASGDRTIKVWNT----STCEFVRTLN 463
Query: 549 QHVEMTAMALDESERCLLTGLRDGTMKMWNYNIGKCLLTFPSPEQLEISGIIHMNKVFYV 608
H A L +R +++G D T+++W+ G CL E+L + I NK
Sbjct: 464 GHKRGIA-CLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEEL-VRCIRFDNKRIVS 521
Query: 609 TGWSKRITHF-----LFHKTKPVLLCYHWQTYHTEDILSMAKYRNQFLGTSSYSGDILFW 663
+ +I + L + LC H+ + + Q + +SS+ IL W
Sbjct: 522 GAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIV-SSSHDDTILIW 580
Query: 664 NTGTLKPIFNFNASRSPSPLQPKR 687
+ N A+++ P P R
Sbjct: 581 D------FLNDPAAQAEPPRSPSR 598
Score = 33.5 bits (75), Expect = 1.3
Identities = 51/219 (23%), Positives = 91/219 (41%), Gaps = 31/219 (14%)
Query: 326 CEQVKFIPQMN-VVVSCSAIEKSSLVLTILPAKASKKPRLSVLRLRKGILCFDYCPDRNF 384
CE V + N ++V+CS + S+ + + + R ++ R + D+ D +
Sbjct: 383 CEAVLHLRFNNGMMVTCS--KDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDF--DDKY 438
Query: 385 LVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILISVSKDKNIRVWDML 444
+V+ D I++WN + V + GH+ + + R +++S S D IR+WD+
Sbjct: 439 IVSASGDRTIKVWNTSTCEF-VRTLNGHKRGIACLQYRDR---LVVSGSSDNTIRLWDIE 494
Query: 445 DYICLQSFCGKFFALGNCPITSAYFFEKDNTLICSTYSIGILKGYLEAQGLIKARKRTTH 504
CL+ G L C DN I S G G ++ L+ A
Sbjct: 495 CGACLRVLEG-HEELVRC-------IRFDNKRIVS----GAYDGKIKVWDLVAALDPRAP 542
Query: 505 CSPLC---AVLYS-KIFK------QVVSGCLRGTVSVWE 533
LC V +S ++F+ Q+VS T+ +W+
Sbjct: 543 AGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWD 581
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 55.1 bits (131), Expect = 4e-07
Identities = 51/218 (23%), Positives = 87/218 (39%), Gaps = 16/218 (7%)
Query: 370 RKGILCFDYCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSIL 429
+ I D P+ L T +D F+ LWN F + GH+ VT + N +L
Sbjct: 18 KAAITSLDLSPNGKQLATASWDTFLMLWN-FKPHARAYRYVGHKDVVTSVQFSPHGN-LL 75
Query: 430 ISVSKDKNIRVWDMLDYICLQSFCGKF--FALGNCPITSAYFFEKDNTLICSTYSIGILK 487
S S+D+ +R+W + GKF F P+ S F L ++ I
Sbjct: 76 ASASRDRTVRLW-------IPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKV 128
Query: 488 GYLEAQGLIKARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGRKTMEFAVSG 547
+ Q + + R TH + +S + +VS T+ +W+ + F+ S
Sbjct: 129 WSMYRQRFLYSLYRHTHW--VRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSV 186
Query: 548 GQHVEMTAMALDESERCLLTGLRDGTMKMWNYNIGKCL 585
G + + S C+ + D T+K+W+ + K L
Sbjct: 187 G---FANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLL 221
Score = 43.1 bits (100), Expect = 0.002
Identities = 35/139 (25%), Positives = 62/139 (44%), Gaps = 8/139 (5%)
Query: 314 RSYRLKALHPNWCEQVKFIPQMNVVVSCSAIEKSSLVLTILPAKASKKPRLSVLRLRKGI 373
R+YR H + V+F P N++ S S + V +P K K +
Sbjct: 52 RAYRYVG-HKDVVTSVQFSPHGNLLASAS---RDRTVRLWIPDKRGKFSEFKAHTAP--V 105
Query: 374 LCFDYCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILISVS 433
D+ D FL T D I++W+ + +R ++ + H T S + +++S S
Sbjct: 106 RSVDFSADGQFLATASEDKSIKVWSMY-RQRFLYSLYRH-THWVRCAKFSPDGRLIVSCS 163
Query: 434 KDKNIRVWDMLDYICLQSF 452
+DK I++WD + C+ +F
Sbjct: 164 EDKTIKIWDTTNKQCVNNF 182
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 54.7 bits (130), Expect = 6e-07
Identities = 72/316 (22%), Positives = 126/316 (39%), Gaps = 27/316 (8%)
Query: 371 KGILCFDYCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILI 430
KG+ C Y D +++G D I++W+ S + ++ GH SV + D R +++
Sbjct: 241 KGVYCLQY--DDEKIISGLRDNSIKIWDK-TSLECLKVLTGHTGSVLCLQYDER---VIV 294
Query: 431 SVSKDKNIRVWDMLDYICLQSFCGKFFALGNCPITSAYFFEKDNTLICSTYSIGILKGYL 490
+ S D +RVWD+ L + A+ + ++ + CS +
Sbjct: 295 TGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLM------VTCSKDRSIAVWDMA 348
Query: 491 EAQGLIKARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGRKTMEFAVSGGQH 550
A + R H + + V + K +VS T+ VW T EF + H
Sbjct: 349 SATDITLRRVLVGHRAAVNVVDFDD--KYIVSASGDRTIKVWST----STCEFVRTLNGH 402
Query: 551 VEMTAMALDESERCLLTGLRDGTMKMWNYNIGKCLLTFPSPEQLEISGIIHMNKVFYVTG 610
A L +R +++G D T+++W+ G CL E+L + I NK
Sbjct: 403 KRGIA-CLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEEL-VRCIRFDNKRIVSGA 460
Query: 611 WSKRITHF-----LFHKTKPVLLCYHWQTYHTEDILSMAKYRNQFLGTSSYSGDILFWNT 665
+ +I + L + LC H+ + + Q + +SS+ IL W+
Sbjct: 461 YDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQII-SSSHDDTILIWDF 519
Query: 666 GTLKPIFNFNASRSPS 681
+ P N +RSPS
Sbjct: 520 LNVPPSAQ-NETRSPS 534
Score = 48.1 bits (113), Expect = 5e-05
Identities = 51/227 (22%), Positives = 93/227 (40%), Gaps = 33/227 (14%)
Query: 361 KPRLSVLRLRKG----ILCFDYCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSV 416
K L L++ G +LC Y D +VTG D+ +R+W+ + L+ H +V
Sbjct: 267 KTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVNTGEVLNTLIH-HNEAV 323
Query: 417 THILVDSRNNSILISVSKDKNIRVWDM---LDYICLQSFCGKFFALGNCPITSAYFFEKD 473
H+ +N ++++ SKD++I VWDM D + G A+ Y
Sbjct: 324 LHLRF---SNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSAS 380
Query: 474 NTLICSTYSIGILKGYLEAQGLIKARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWE 533
+S + G H + + Y + VVSG T+ +W+
Sbjct: 381 GDRTIKVWSTSTCEFVRTLNG---------HKRGIACLQYRD--RLVVSGSSDNTIRLWD 429
Query: 534 VVTGR--KTMEFAVSGGQHVEMTAMALDESERCLLTGLRDGTMKMWN 578
+ G + +E H E+ +++R +++G DG +K+W+
Sbjct: 430 IECGACLRVLE------GHEELVRCIRFDNKR-IVSGAYDGKIKVWD 469
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 54.7 bits (130), Expect = 6e-07
Identities = 72/316 (22%), Positives = 126/316 (39%), Gaps = 27/316 (8%)
Query: 371 KGILCFDYCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILI 430
KG+ C Y D +++G D I++W+ S + ++ GH SV + D R +++
Sbjct: 207 KGVYCLQY--DDEKIISGLRDNSIKIWDK-TSLECLKVLTGHTGSVLCLQYDER---VIV 260
Query: 431 SVSKDKNIRVWDMLDYICLQSFCGKFFALGNCPITSAYFFEKDNTLICSTYSIGILKGYL 490
+ S D +RVWD+ L + A+ + ++ + CS +
Sbjct: 261 TGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLM------VTCSKDRSIAVWDMA 314
Query: 491 EAQGLIKARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGRKTMEFAVSGGQH 550
A + R H + + V + K +VS T+ VW T EF + H
Sbjct: 315 SATDITLRRVLVGHRAAVNVVDFDD--KYIVSASGDRTIKVWST----STCEFVRTLNGH 368
Query: 551 VEMTAMALDESERCLLTGLRDGTMKMWNYNIGKCLLTFPSPEQLEISGIIHMNKVFYVTG 610
A L +R +++G D T+++W+ G CL E+L + I NK
Sbjct: 369 KRGIA-CLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEEL-VRCIRFDNKRIVSGA 426
Query: 611 WSKRITHF-----LFHKTKPVLLCYHWQTYHTEDILSMAKYRNQFLGTSSYSGDILFWNT 665
+ +I + L + LC H+ + + Q + +SS+ IL W+
Sbjct: 427 YDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQII-SSSHDDTILIWDF 485
Query: 666 GTLKPIFNFNASRSPS 681
+ P N +RSPS
Sbjct: 486 LNVPPSAQ-NETRSPS 500
Score = 48.1 bits (113), Expect = 5e-05
Identities = 51/227 (22%), Positives = 93/227 (40%), Gaps = 33/227 (14%)
Query: 361 KPRLSVLRLRKG----ILCFDYCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSV 416
K L L++ G +LC Y D +VTG D+ +R+W+ + L+ H +V
Sbjct: 233 KTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVNTGEVLNTLIH-HNEAV 289
Query: 417 THILVDSRNNSILISVSKDKNIRVWDM---LDYICLQSFCGKFFALGNCPITSAYFFEKD 473
H+ +N ++++ SKD++I VWDM D + G A+ Y
Sbjct: 290 LHLRF---SNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSAS 346
Query: 474 NTLICSTYSIGILKGYLEAQGLIKARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWE 533
+S + G H + + Y + VVSG T+ +W+
Sbjct: 347 GDRTIKVWSTSTCEFVRTLNG---------HKRGIACLQYRD--RLVVSGSSDNTIRLWD 395
Query: 534 VVTGR--KTMEFAVSGGQHVEMTAMALDESERCLLTGLRDGTMKMWN 578
+ G + +E H E+ +++R +++G DG +K+W+
Sbjct: 396 IECGACLRVLE------GHEELVRCIRFDNKR-IVSGAYDGKIKVWD 435
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 54.7 bits (130), Expect = 6e-07
Identities = 72/316 (22%), Positives = 126/316 (39%), Gaps = 27/316 (8%)
Query: 371 KGILCFDYCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILI 430
KG+ C Y D +++G D I++W+ S + ++ GH SV + D R +++
Sbjct: 228 KGVYCLQY--DDEKIISGLRDNSIKIWDK-TSLECLKVLTGHTGSVLCLQYDER---VIV 281
Query: 431 SVSKDKNIRVWDMLDYICLQSFCGKFFALGNCPITSAYFFEKDNTLICSTYSIGILKGYL 490
+ S D +RVWD+ L + A+ + ++ + CS +
Sbjct: 282 TGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLM------VTCSKDRSIAVWDMA 335
Query: 491 EAQGLIKARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGRKTMEFAVSGGQH 550
A + R H + + V + K +VS T+ VW T EF + H
Sbjct: 336 SATDITLRRVLVGHRAAVNVVDFDD--KYIVSASGDRTIKVWST----STCEFVRTLNGH 389
Query: 551 VEMTAMALDESERCLLTGLRDGTMKMWNYNIGKCLLTFPSPEQLEISGIIHMNKVFYVTG 610
A L +R +++G D T+++W+ G CL E+L + I NK
Sbjct: 390 KRGIA-CLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEEL-VRCIRFDNKRIVSGA 447
Query: 611 WSKRITHF-----LFHKTKPVLLCYHWQTYHTEDILSMAKYRNQFLGTSSYSGDILFWNT 665
+ +I + L + LC H+ + + Q + +SS+ IL W+
Sbjct: 448 YDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQII-SSSHDDTILIWDF 506
Query: 666 GTLKPIFNFNASRSPS 681
+ P N +RSPS
Sbjct: 507 LNVPPSAQ-NETRSPS 521
Score = 48.1 bits (113), Expect = 5e-05
Identities = 51/227 (22%), Positives = 93/227 (40%), Gaps = 33/227 (14%)
Query: 361 KPRLSVLRLRKG----ILCFDYCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSV 416
K L L++ G +LC Y D +VTG D+ +R+W+ + L+ H +V
Sbjct: 254 KTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVNTGEVLNTLIH-HNEAV 310
Query: 417 THILVDSRNNSILISVSKDKNIRVWDM---LDYICLQSFCGKFFALGNCPITSAYFFEKD 473
H+ +N ++++ SKD++I VWDM D + G A+ Y
Sbjct: 311 LHLRF---SNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSAS 367
Query: 474 NTLICSTYSIGILKGYLEAQGLIKARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWE 533
+S + G H + + Y + VVSG T+ +W+
Sbjct: 368 GDRTIKVWSTSTCEFVRTLNG---------HKRGIACLQYRD--RLVVSGSSDNTIRLWD 416
Query: 534 VVTGR--KTMEFAVSGGQHVEMTAMALDESERCLLTGLRDGTMKMWN 578
+ G + +E H E+ +++R +++G DG +K+W+
Sbjct: 417 IECGACLRVLE------GHEELVRCIRFDNKR-IVSGAYDGKIKVWD 456
>gi|110815834 F-box and WD-40 domain protein 10 [Homo sapiens]
Length = 1051
Score = 53.5 bits (127), Expect = 1e-06
Identities = 72/323 (22%), Positives = 123/323 (38%), Gaps = 75/323 (23%)
Query: 303 QKLLNEKSALHRSYRLKALHPNWCEQVKFIPQMNVVVSCSAIEKSSLVLTILPAKASKKP 362
Q L+ E++ +Y ++ L W + +++ S+ K L L I+ KA
Sbjct: 390 QVLIEERNVFCGTYNVRILSDTWDQNRVIHYSGGDLIAVSSNRKIHL-LDIIQVKAIPVE 448
Query: 363 RLSVLRLRKG-ILCFDYCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILV 421
R G + C + NFL++G YD IR W+ S + GHQ ++T +
Sbjct: 449 ----FRGHAGSVRALFLCEEENFLLSGSYDLSIRYWD-LKSGVCTRIFGGHQGTIT--CM 501
Query: 422 DSRNNSILISVSKDKNIRVWDMLDYICLQSFCGKFFALGNCPITSAYFFEKDNTLICSTY 481
D N L+S +D ++VWD+ CL++F
Sbjct: 502 DLCKNR-LVSGGRDCQVKVWDVDTGKCLKTF----------------------------- 531
Query: 482 SIGILKGYLEAQGLIKARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGR--K 539
H P+ A + + +VS C RG V VW + + K
Sbjct: 532 ---------------------RHKDPILATRINDTY--IVSSCERGLVKVWHIAMAQLVK 568
Query: 540 TMEFAVSGGQHVEMTAMALDESERCLLTGLRDGTMKMWNYNIGK---CLLTFPSPEQLEI 596
T+ G + + D+ LL+G DG + W+ +GK CL+ F P+++
Sbjct: 569 TL-----SGHEGAVKCLFFDQWH--LLSGSTDGLVMAWSM-VGKYERCLMAFKHPKEVLD 620
Query: 597 SGIIHMNKVFYVTGWSKRITHFL 619
++ + + RI +FL
Sbjct: 621 VSLLFLRVISACADGKIRIYNFL 643
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 53.1 bits (126), Expect = 2e-06
Identities = 54/239 (22%), Positives = 97/239 (40%), Gaps = 30/239 (12%)
Query: 391 DAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILISVSKDKNIRVWDMLDYICLQ 450
D I+LW+ F + M GH +V+ + + N ++S S+DK I++W++ C++
Sbjct: 171 DMTIKLWD-FQGFECIRTMHGHDHNVSSVAI-MPNGDHIVSASRDKTIKMWEVQTGYCVK 228
Query: 451 SFCGKFFALGNCPITSAYFFEKDNTLICSTYSIGILKGYLEAQGLIKARKRTTHCSPLCA 510
+F G + +D TLI S + ++ ++ A KA R C
Sbjct: 229 TFTG------HREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECI 282
Query: 511 VL-----YSKIFKQ--------------VVSGCLRGTVSVWEVVTGRKTMEFAVSGGQHV 551
YS I + ++SG T+ +W+V TG M G
Sbjct: 283 SWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLV---GHDN 339
Query: 552 EMTAMALDESERCLLTGLRDGTMKMWNYNIGKCLLTFPSPEQLEISGIIHMNKVFYVTG 610
+ + + +L+ D T+++W+Y +C+ T + E S H + VTG
Sbjct: 340 WVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTG 398
Score = 48.5 bits (114), Expect = 4e-05
Identities = 55/236 (23%), Positives = 97/236 (41%), Gaps = 48/236 (20%)
Query: 380 PDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILISVSKDKNIR 439
P + +V+ DA I++W+ + + +KGH SV I D + +L S S D I+
Sbjct: 118 PVFSVMVSASEDATIKVWD-YETGDFERTLKGHTDSVQDISFD-HSGKLLASCSADMTIK 175
Query: 440 VWDMLDYICLQSFCGKFFALGNCPI----TSAYFFEKDNTL----ICSTYSIGILKGYLE 491
+WD + C+++ G + + I +D T+ + + Y + G+ E
Sbjct: 176 LWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHRE 235
Query: 492 AQGLIKARKRTTHCSPLCAVLYSKIFKQVVSGCLRG-TVSVWEVVTGRKTMEFAVSGGQH 550
+++ + T +++ C TV VW V T K + + +H
Sbjct: 236 WVRMVRPNQDGT----------------LIASCSNDQTVRVWVVAT--KECKAELREHEH 277
Query: 551 V----------------EMTAMALDESER---CLLTGLRDGTMKMWNYNIGKCLLT 587
V E T +S + LL+G RD T+KMW+ + G CL+T
Sbjct: 278 VVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMT 333
Score = 40.4 bits (93), Expect = 0.011
Identities = 23/86 (26%), Positives = 44/86 (51%), Gaps = 7/86 (8%)
Query: 504 HCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTG--RKTMEFAVSGGQHVEMTAMALDES 561
H SP+ V++ +F +VS T+ VW+ TG +T++ G + ++ D S
Sbjct: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLK-----GHTDSVQDISFDHS 161
Query: 562 ERCLLTGLRDGTMKMWNYNIGKCLLT 587
+ L + D T+K+W++ +C+ T
Sbjct: 162 GKLLASCSADMTIKLWDFQGFECIRT 187
Score = 33.9 bits (76), Expect = 1.0
Identities = 33/149 (22%), Positives = 60/149 (40%), Gaps = 19/149 (12%)
Query: 945 LMTWKGHLNSVADILYVDNFQLVISAGQDRDVKAWKL-SGDAIGTF-GLSVWKRL-QDAC 1001
+ T GH ++V+ + + N ++SA +D+ +K W++ +G + TF G W R+ +
Sbjct: 185 IRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQ 244
Query: 1002 DGPRENRASLEEDGDSTGTTQKVLHLELQEQRDLAEALIYQRREQAALMA---------- 1051
DG S ++ K EL+E + E + + + ++
Sbjct: 245 DGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKS 304
Query: 1052 ------LLHGKADKEADTWAKLQKMALMS 1074
LL G DK W M LM+
Sbjct: 305 GKPGPFLLSGSRDKTIKMWDVSTGMCLMT 333
Score = 31.2 bits (69), Expect = 6.7
Identities = 14/37 (37%), Positives = 20/37 (54%)
Query: 947 TWKGHLNSVADILYVDNFQLVISAGQDRDVKAWKLSG 983
T KGH +SV DI + + +L+ S D +K W G
Sbjct: 145 TLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQG 181
>gi|157694487 CMT1A duplicated region transcript 1 [Homo sapiens]
Length = 752
Score = 52.0 bits (123), Expect = 4e-06
Identities = 71/322 (22%), Positives = 122/322 (37%), Gaps = 75/322 (23%)
Query: 303 QKLLNEKSALHRSYRLKALHPNWCEQVKFIPQMNVVVSCSAIEKSSLVLTILPAKASKKP 362
Q L+ E++ +Y ++ L W + +++ S+ K L L I+ KA
Sbjct: 390 QVLMEERNVFCGTYNVRILSDTWDQNRVIHYSGGDLIAVSSNRKIHL-LDIIQVKAIPVE 448
Query: 363 RLSVLRLRKG-ILCFDYCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILV 421
R G + C + NFL++G YD IR W+ S + GHQ ++T +
Sbjct: 449 ----FRGHAGSVRALFLCEEENFLLSGSYDLSIRYWD-LKSGVCTRIFGGHQGTIT--CM 501
Query: 422 DSRNNSILISVSKDKNIRVWDMLDYICLQSFCGKFFALGNCPITSAYFFEKDNTLICSTY 481
D N L+S +D ++VWD+ CL++F
Sbjct: 502 DLCKNR-LVSGGRDCQVKVWDVDTGKCLKTF----------------------------- 531
Query: 482 SIGILKGYLEAQGLIKARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGR--K 539
H P+ A + + +VS C RG V VW + + K
Sbjct: 532 ---------------------RHKDPILATRINDTY--IVSSCERGLVKVWHIAMAQLVK 568
Query: 540 TMEFAVSGGQHVEMTAMALDESERCLLTGLRDGTMKMWNYNIGK---CLLTFPSPEQLEI 596
T+ G + + D+ LL+G DG + W+ +GK CL+ F P+++
Sbjct: 569 TL-----SGHEGAVKCLFFDQWH--LLSGSTDGLVMAWSM-VGKYERCLMAFKHPKEVLD 620
Query: 597 SGIIHMNKVFYVTGWSKRITHF 618
++ + + RI +F
Sbjct: 621 VSLLFLRVISACADGKIRIYNF 642
>gi|62234438 Notchless gene homolog isoform b [Homo sapiens]
Length = 193
Score = 52.0 bits (123), Expect = 4e-06
Identities = 47/156 (30%), Positives = 76/156 (48%), Gaps = 16/156 (10%)
Query: 380 PDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILISVSKDKNIR 439
P+R LV+G D + LW+P K+P+ M GHQ + +L S ++ I+ S S DK+I+
Sbjct: 49 PER--LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLF-SPDSRIVASASFDKSIK 105
Query: 440 VWDMLDYICLQSFCGKFFALGNCPITSAY--FFEKDNTLICSTYSIGILKGY-LEAQGLI 496
+WD GK+ A + + Y + D+ L+ S S LK + ++AQ L
Sbjct: 106 LWD--------GRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKL- 156
Query: 497 KARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVW 532
A H + AV +S ++V SG + +W
Sbjct: 157 -AMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 191
Score = 36.6 bits (83), Expect = 0.16
Identities = 19/66 (28%), Positives = 36/66 (54%), Gaps = 2/66 (3%)
Query: 378 YCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILISVSKDKN 437
+ PD + + +D I+LW+ K + ++GH +V I S ++ +L+S S D
Sbjct: 88 FSPDSRIVASASFDKSIKLWDGRTGKY-LASLRGHVAAVYQI-AWSADSRLLVSGSSDST 145
Query: 438 IRVWDM 443
++VWD+
Sbjct: 146 LKVWDV 151
Score = 34.3 bits (77), Expect = 0.79
Identities = 27/113 (23%), Positives = 47/113 (41%), Gaps = 14/113 (12%)
Query: 500 KRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGRKTMEFAVSGGQHVEMTAMALD 559
+ T H + + VL+S + V S ++ +W+ TG+ A G + +A
Sbjct: 75 RMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKY---LASLRGHVAAVYQIAWS 131
Query: 560 ESERCLLTGLRDGTMKMWNYNIGKCLLTFPSPEQLEISGIIHMNKVFYVTGWS 612
R L++G D T+K+W+ K + P H ++V Y WS
Sbjct: 132 ADSRLLVSGSSDSTLKVWDVKAQKLAMDLPG----------HADEV-YAVDWS 173
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 52.0 bits (123), Expect = 4e-06
Identities = 47/156 (30%), Positives = 76/156 (48%), Gaps = 16/156 (10%)
Query: 380 PDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILISVSKDKNIR 439
P+R LV+G D + LW+P K+P+ M GHQ + +L S ++ I+ S S DK+I+
Sbjct: 341 PER--LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLF-SPDSRIVASASFDKSIK 397
Query: 440 VWDMLDYICLQSFCGKFFALGNCPITSAY--FFEKDNTLICSTYSIGILKGY-LEAQGLI 496
+WD GK+ A + + Y + D+ L+ S S LK + ++AQ L
Sbjct: 398 LWD--------GRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKL- 448
Query: 497 KARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVW 532
A H + AV +S ++V SG + +W
Sbjct: 449 -AMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 40.4 bits (93), Expect = 0.011
Identities = 53/269 (19%), Positives = 101/269 (37%), Gaps = 53/269 (19%)
Query: 380 PDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILISVSKDKNIR 439
P+ ++ + D +R+W+ + R ++ GH SVT + + +L S S+D+ I+
Sbjct: 214 PECRYVASSSKDGSVRIWDT-TAGRCERILTGHTQSVTCLRWGG--DGLLYSASQDRTIK 270
Query: 440 VWDMLDYICLQSFCGKFFALGNCPITSAYF-----FEKDNTLICSTYSIGILKGY----L 490
VW D + ++ G + +++ Y FE + G L+ L
Sbjct: 271 VWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERAL 330
Query: 491 EAQGLIKAR---------------------------KRTTHCSPLCAVLYSKIFKQVVSG 523
L++ + + T H + + VL+S + V S
Sbjct: 331 SRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASA 390
Query: 524 CLRGTVSVWEVVTGRKTMEFAVSGGQHVEMTAMALDESERCLLTGLRDGTMKMWNYNIGK 583
++ +W+ TG+ A G + +A R L++G D T+K+W+ K
Sbjct: 391 SFDKSIKLWDGRTGKY---LASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQK 447
Query: 584 CLLTFPSPEQLEISGIIHMNKVFYVTGWS 612
+ P H ++V Y WS
Sbjct: 448 LAMDLPG----------HADEV-YAVDWS 465
Score = 37.0 bits (84), Expect = 0.12
Identities = 23/89 (25%), Positives = 41/89 (46%), Gaps = 4/89 (4%)
Query: 358 ASKKPRLSVLRLRKGILCFDYCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVT 417
+++ P + R +L + PD L +G + I LW+P K+ + GH +T
Sbjct: 144 STETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWIT 203
Query: 418 HI----LVDSRNNSILISVSKDKNIRVWD 442
+ L + + S SKD ++R+WD
Sbjct: 204 GLSWEPLHANPECRYVASSSKDGSVRIWD 232
Score = 36.6 bits (83), Expect = 0.16
Identities = 19/66 (28%), Positives = 36/66 (54%), Gaps = 2/66 (3%)
Query: 378 YCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILISVSKDKN 437
+ PD + + +D I+LW+ K + ++GH +V I S ++ +L+S S D
Sbjct: 380 FSPDSRIVASASFDKSIKLWDGRTGKY-LASLRGHVAAVYQI-AWSADSRLLVSGSSDST 437
Query: 438 IRVWDM 443
++VWD+
Sbjct: 438 LKVWDV 443
Score = 32.3 bits (72), Expect = 3.0
Identities = 15/78 (19%), Positives = 40/78 (51%), Gaps = 3/78 (3%)
Query: 510 AVLYSKIFKQVVSGCLRGTVSVWEVVTGRKTMEFAVSGGQHVE-MTAMALDESERC--LL 566
++ +S +++ SGC G + +W+ TG++ + + ++ L + C +
Sbjct: 161 SISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVA 220
Query: 567 TGLRDGTMKMWNYNIGKC 584
+ +DG++++W+ G+C
Sbjct: 221 SSSKDGSVRIWDTTAGRC 238
>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
[Homo sapiens]
Length = 340
Score = 49.7 bits (117), Expect = 2e-05
Identities = 58/251 (23%), Positives = 98/251 (39%), Gaps = 46/251 (18%)
Query: 386 VTGGYDAFIRLWNPFVSKRPVWLMKGHQTSV--THILVDSRNNSILISVSKDKNIRVWDM 443
+T G D R + R ++GH + H DSR +L+S S+D + +WD
Sbjct: 33 ITAGLDPVGR-----IQMRTRRTLRGHLAKIYAMHWGTDSR---LLVSASQDGKLIIWDS 84
Query: 444 LD--------------YICLQSFCGKFFALGNCPITSAYFFEKDNTLICSTYSIGILKGY 489
C + G F A G DN ICS YS+ +G
Sbjct: 85 YTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGL----------DN--ICSIYSLKTREGN 132
Query: 490 LEAQGLIKARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGRKTMEFAVSGGQ 549
+ + C C L Q+++ T ++W++ TG++T+ FA G
Sbjct: 133 VRVSRELPGHTGYLSC---CRFLDD---NQIITSSGDTTCALWDIETGQQTVGFA---GH 183
Query: 550 HVEMTAMALDESERCLLTGLRDGTMKMWNYNIGKCLLTFPSPEQLEISGIIHMNKVFYVT 609
++ +++L R ++G D ++K+W+ C TF E +I+ + + T
Sbjct: 184 SGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHES-DINAVAFFPNGYAFT 242
Query: 610 GWSKRITHFLF 620
S T LF
Sbjct: 243 TGSDDATCRLF 253
Score = 43.9 bits (102), Expect = 0.001
Identities = 45/258 (17%), Positives = 100/258 (38%), Gaps = 12/258 (4%)
Query: 321 LHPNWCEQVKFIPQMNVVVSCSAIEKSSLVLTILPAKASKKPRLSVLRLRKGILCFDYCP 380
L +W + P N V +C ++ + ++ + + + + + C +
Sbjct: 95 LRSSWVMTCAYAPSGNFV-ACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLD 153
Query: 381 DRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILISVSKDKNIRV 440
D N ++T D LW+ ++ V GH V + + + + +S + D +I++
Sbjct: 154 D-NQIITSSGDTTCALWDIETGQQTVGFA-GHSGDVMSLSL-APDGRTFVSGACDASIKL 210
Query: 441 WDMLDYICLQSFCGKFFALGNCPITSAYFFEKDNTLICSTYSIGILKGYLEAQGLIKARK 500
WD+ D +C Q+F G I + FF + L A +
Sbjct: 211 WDVRDSMCRQTFIGH-----ESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYS 265
Query: 501 RTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGRKTMEFAVSGGQHVEMTAMALDE 560
+ +V +S+ + +++G ++W+ + G + V G ++ + + +
Sbjct: 266 HDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRA---GVLAGHDNRVSCLGVTD 322
Query: 561 SERCLLTGLRDGTMKMWN 578
+ TG D +K+WN
Sbjct: 323 DGMAVATGSWDSFLKIWN 340
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 48.9 bits (115), Expect = 3e-05
Identities = 39/165 (23%), Positives = 72/165 (43%), Gaps = 9/165 (5%)
Query: 378 YCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILISVSKDKN 437
+ P + V+GG+D RLW +P+ + GH V +N + S D+
Sbjct: 593 FSPYGYYFVSGGHDRVARLWATD-HYQPLRIFAGHLADVNCTRFHPNSNYVATG-SADRT 650
Query: 438 IRVWDMLDYICLQSFCGKFFALGNCPITSAYFFEKDNTLICSTYSIGILKGYLEAQGLIK 497
+R+WD+L+ C++ F G PI S F L +L + GL+
Sbjct: 651 VRLWDVLNGNCVRIFTGH-----KGPIHSLTFSPNGRFLATGATDGRVLLWDI-GHGLMV 704
Query: 498 ARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGRKTME 542
+ H +C++ +S+ + + SG + TV +W+ + + +E
Sbjct: 705 GELK-GHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLE 748
Score = 38.1 bits (87), Expect = 0.055
Identities = 39/171 (22%), Positives = 64/171 (37%), Gaps = 32/171 (18%)
Query: 423 SRNNSILISVSKDKNIRVWDMLDYICLQSFCGKFFALGNCPITSAYFFEKDNTLICSTYS 482
S + + L+S S+D +R+W + + CL + G N P+ F S Y
Sbjct: 552 SPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGH-----NYPVWDTQF---------SPYG 597
Query: 483 IGILKGYLEAQGLIKARKRTTHCSPL-----------CAVLYSKIFKQVVSGCLRGTVSV 531
+ G + + A T H PL C + V +G TV +
Sbjct: 598 YYFVSGGHDRVARLWA---TDHYQPLRIFAGHLADVNCTRFHPNS-NYVATGSADRTVRL 653
Query: 532 WEVVTGRKTMEFAVSGGQHVEMTAMALDESERCLLTGLRDGTMKMWNYNIG 582
W+V+ G F G + ++ + R L TG DG + +W+ G
Sbjct: 654 WDVLNGNCVRIFT---GHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHG 701
Score = 37.7 bits (86), Expect = 0.071
Identities = 20/69 (28%), Positives = 36/69 (52%), Gaps = 2/69 (2%)
Query: 375 CFDYCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILISVSK 434
C + P+ N++ TG D +RLW+ ++ V + GH+ + H L S N L + +
Sbjct: 632 CTRFHPNSNYVATGSADRTVRLWD-VLNGNCVRIFTGHKGPI-HSLTFSPNGRFLATGAT 689
Query: 435 DKNIRVWDM 443
D + +WD+
Sbjct: 690 DGRVLLWDI 698
>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
sapiens]
Length = 513
Score = 48.9 bits (115), Expect = 3e-05
Identities = 46/224 (20%), Positives = 79/224 (35%), Gaps = 61/224 (27%)
Query: 375 CFDYCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVD--------SRNN 426
C + PD +LVTG D FI +WN K L +Q +++D SR+
Sbjct: 219 CARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLK--YQAQDNFMMMDDAVLCMCFSRDT 276
Query: 427 SILISVSKDKNIRVWDMLDYICLQSFCGKFFALGNCPITSAYFFEKDNTLICSTYSIGIL 486
+L + ++D I+VW + CL+ F
Sbjct: 277 EMLATGAQDGKIKVWKIQSGQCLRRF---------------------------------- 302
Query: 487 KGYLEAQGLIKARKRTTHCSPLCAVLYSKIFKQVVSGCLRGTVSVWEVVTGRKTMEFAVS 546
H + + +SK Q++S T+ + + +G+ EF
Sbjct: 303 --------------ERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFR-- 346
Query: 547 GGQHVEMTAMALDESERCLLTGLRDGTMKMWNYNIGKCLLTFPS 590
G + + +++ DGT+K+WN +C TF S
Sbjct: 347 -GHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKS 389
Score = 40.0 bits (92), Expect = 0.014
Identities = 34/152 (22%), Positives = 51/152 (33%), Gaps = 24/152 (15%)
Query: 520 VVSGCLRGTVSVWEVVTGRKTMEFAVSGGQHVEMT-----AMALDESERCLLTGLRDGTM 574
+V+G + G + VW TG+ + + M M L TG +DG +
Sbjct: 229 LVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKI 288
Query: 575 KMWNYNIGKCLLTFPSPEQLEISGIIHMNKVFYVTGWSKRITHFLFHKTKPVLLCYHWQT 634
K+W G+CL F SK +T F K +L +
Sbjct: 289 KVWKIQSGQCLRRFERAH-------------------SKGVTCLSFSKDSSQILSASFDQ 329
Query: 635 YHTEDILSMAKYRNQFLGTSSYSGDILFWNTG 666
L K +F G SS+ + F G
Sbjct: 330 TIRIHGLKSGKTLKEFRGHSSFVNEATFTQDG 361
Score = 38.9 bits (89), Expect = 0.032
Identities = 43/175 (24%), Positives = 71/175 (40%), Gaps = 28/175 (16%)
Query: 815 PHTAALLSSCMDGYIYAWSLHENGGLLGKFPVDL-----DNG---DVVVGAMATDKNDWI 866
P L++ +DG+I W+ GK DL DN D V M ++ +
Sbjct: 224 PDGQYLVTGSVDGFIEVWNF-----TTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEM 278
Query: 867 LITGDCKGYIKIWDIKDYCALIDKQPFQSSGAKVVSEAHNKFRLLIPQQLGTNFPHYIPL 926
L TG G IK+W I+ L + S G +S + + ++L +F I +
Sbjct: 279 LATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQIL-----SASFDQTIRI 333
Query: 927 EDKEVVAGHTISLVPPTLLMTWKGHLNSVADILYVDNFQLVISAGQDRDVKAWKL 981
+ +G T L ++GH + V + + + +ISA D VK W +
Sbjct: 334 HGLK--SGKT--------LKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNM 378
Score = 38.5 bits (88), Expect = 0.042
Identities = 46/211 (21%), Positives = 83/211 (39%), Gaps = 19/211 (9%)
Query: 299 KVSLQKLLNEKSALHRSYRLKALHPNWCEQVKFIPQMNVVVSCSA---IEKSSLVLTILP 355
K +++ + EK S +K + E +F P +V+ S IE + +
Sbjct: 190 KAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIR 249
Query: 356 AKASKKPRLSVLRLRKGILCFDYCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTS 415
+ + + + + +LC + D L TG D I++W + + H
Sbjct: 250 KDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKG 309
Query: 416 VTHILVDSRNNSILISVSKDKNIRVWDMLDYICLQSFCGKFFALGNCPITSAYFFEKDNT 475
VT L S+++S ++S S D+ IR+ + L+ F G+ + F +D
Sbjct: 310 VT-CLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEF------RGHSSFVNEATFTQDGH 362
Query: 476 LICSTYSIGILKGYLEAQGLIKARKRTTHCS 506
I S S G +K + +TT CS
Sbjct: 363 YIISASSDGTVKIW---------NMKTTECS 384
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
[Homo sapiens]
Length = 340
Score = 47.4 bits (111), Expect = 9e-05
Identities = 46/200 (23%), Positives = 79/200 (39%), Gaps = 40/200 (20%)
Query: 409 MKGHQTSV--THILVDSRNNSILISVSKDKNIRVWDMLD--------------YICLQSF 452
++GH + H DSR +L+S S+D + +WD C +
Sbjct: 51 LRGHLAKIYAMHWGTDSR---LLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAP 107
Query: 453 CGKFFALGNCPITSAYFFEKDNTLICSTYSIGILKGYLEAQGLIKARKRTTHCSPLCAVL 512
G + A G DN ICS Y++ +G + + C C L
Sbjct: 108 SGNYVACGGL----------DN--ICSIYNLKTREGNVRVSRELAGHTGYLSC---CRFL 152
Query: 513 YSKIFKQVVSGCLRGTVSVWEVVTGRKTMEFAVSGGQHVEMTAMALDESERCLLTGLRDG 572
Q+V+ T ++W++ TG++T F G ++ +++L R ++G D
Sbjct: 153 DDN---QIVTSSGDTTCALWDIETGQQTTTFT---GHTGDVMSLSLAPDTRLFVSGACDA 206
Query: 573 TMKMWNYNIGKCLLTFPSPE 592
+ K+W+ G C TF E
Sbjct: 207 SAKLWDVREGMCRQTFTGHE 226
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 47.0 bits (110), Expect = 1e-04
Identities = 45/223 (20%), Positives = 88/223 (39%), Gaps = 14/223 (6%)
Query: 399 PFVSKRPVWLMK---GHQTSVTHILVDSRNNSILISVSKDKNIRVWDMLDYICLQSFCGK 455
P V+K W ++ H ++V+ +++ + +L + D + +W + C+ S G
Sbjct: 4 PVVTKT-AWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGH 62
Query: 456 FFALGNCPITSAYFFEKDNTLICSTYSIGILKGYLEAQGLIKARKRTTHCSPLCAVLYSK 515
P+ S + ++ + S I LEA ++ R H + +C++ +
Sbjct: 63 -----TSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKIL--RTLMGHKANICSLDFHP 115
Query: 516 IFKQVVSGCLRGTVSVWEVVTGRKTMEFAVSGGQHVEMTAMALDESERCLLTGLRDGTMK 575
+ V SG + +W++ RK F G + + + L + D T+K
Sbjct: 116 YGEFVASGSQDTNIKLWDI--RRKGCVFRYRGHSQA-VRCLRFSPDGKWLASAADDHTVK 172
Query: 576 MWNYNIGKCLLTFPSPEQLEISGIIHMNKVFYVTGWSKRITHF 618
+W+ GK + FP H N+ +G S R F
Sbjct: 173 LWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRF 215
Score = 35.4 bits (80), Expect = 0.35
Identities = 19/73 (26%), Positives = 36/73 (49%), Gaps = 2/73 (2%)
Query: 371 KGILCFDYCPDRNFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILI 430
+ + C + PD +L + D ++LW+ + + + GH T +++ N +L
Sbjct: 148 QAVRCLRFSPDGKWLASAADDHTVKLWD-LTAGKMMSEFPGH-TGPVNVVEFHPNEYLLA 205
Query: 431 SVSKDKNIRVWDM 443
S S D+ IR WD+
Sbjct: 206 SGSSDRTIRFWDL 218
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.133 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 50,087,771
Number of Sequences: 37866
Number of extensions: 2294154
Number of successful extensions: 9835
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 63
Number of HSP's successfully gapped in prelim test: 218
Number of HSP's that attempted gapping in prelim test: 8178
Number of HSP's gapped (non-prelim): 1656
length of query: 1288
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1174
effective length of database: 13,930,794
effective search space: 16354752156
effective search space used: 16354752156
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.