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Search of human proteins with 22035548
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22035548 amyloid beta A4 precursor protein-binding, family
A, member 1 [Homo sapiens]
(837 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22035548 amyloid beta A4 precursor protein-binding, family A,... 1672 0.0
gi|22035550 amyloid beta A4 precursor protein-binding, family A,... 719 0.0
gi|194353992 amyloid beta A4 precursor protein-binding, family A... 703 0.0
gi|11342678 amyloid beta (A4) precursor protein-binding, family ... 514 e-145
gi|134152672 syndecan binding protein 2 isoform a [Homo sapiens] 67 5e-11
gi|38016916 syndecan binding protein 2 isoform b [Homo sapiens] 67 5e-11
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 65 3e-10
gi|55749523 syntenin isoform 3 [Homo sapiens] 62 2e-09
gi|55749515 syntenin isoform 3 [Homo sapiens] 62 2e-09
gi|55749504 syntenin isoform 2 [Homo sapiens] 62 2e-09
gi|55749490 syntenin isoform 1 [Homo sapiens] 62 2e-09
gi|56243522 syntenin isoform 1 [Homo sapiens] 62 2e-09
gi|112382257 InaD-like [Homo sapiens] 60 8e-09
gi|7705318 GULP, engulfment adaptor PTB domain containing 1 [Hom... 57 5e-08
gi|148746189 multiple PDZ domain protein [Homo sapiens] 57 5e-08
gi|223890252 glutamate receptor interacting protein 1 [Homo sapi... 55 2e-07
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 55 4e-07
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 55 4e-07
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 55 4e-07
gi|222446609 rai-like protein [Homo sapiens] 52 2e-06
gi|122937249 glutamate receptor interacting protein 2 [Homo sapi... 52 2e-06
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 52 3e-06
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 51 4e-06
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 51 4e-06
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 50 9e-06
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 50 9e-06
gi|10835173 nitric oxide synthase 1, neuronal [Homo sapiens] 49 1e-05
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom... 48 3e-05
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom... 48 4e-05
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom... 48 4e-05
>gi|22035548 amyloid beta A4 precursor protein-binding, family A,
member 1 [Homo sapiens]
Length = 837
Score = 1672 bits (4330), Expect = 0.0
Identities = 837/837 (100%), Positives = 837/837 (100%)
Query: 1 MNHLEGSAEVEVTDEAAGGEVNESVEADLEHPEVEEEQQQPPQQQHYVGRHQRGRALEDL 60
MNHLEGSAEVEVTDEAAGGEVNESVEADLEHPEVEEEQQQPPQQQHYVGRHQRGRALEDL
Sbjct: 1 MNHLEGSAEVEVTDEAAGGEVNESVEADLEHPEVEEEQQQPPQQQHYVGRHQRGRALEDL 60
Query: 61 RAQLGQEEEERGECLARSASTESGFHNHTDTAEGDVIAAARDGYDAERAQDPEDESAYAV 120
RAQLGQEEEERGECLARSASTESGFHNHTDTAEGDVIAAARDGYDAERAQDPEDESAYAV
Sbjct: 61 RAQLGQEEEERGECLARSASTESGFHNHTDTAEGDVIAAARDGYDAERAQDPEDESAYAV 120
Query: 121 QYRPEAEEYTEQAEAEHAEATHRRALPNHLHFHSLEHEEAMNAAYSGYVYTHRLFHRGED 180
QYRPEAEEYTEQAEAEHAEATHRRALPNHLHFHSLEHEEAMNAAYSGYVYTHRLFHRGED
Sbjct: 121 QYRPEAEEYTEQAEAEHAEATHRRALPNHLHFHSLEHEEAMNAAYSGYVYTHRLFHRGED 180
Query: 181 EPYSEPYADYGGLQEHVYEEIGDAPELDARDGLRLYEQERDEAAAYRQEALGARLHHYDE 240
EPYSEPYADYGGLQEHVYEEIGDAPELDARDGLRLYEQERDEAAAYRQEALGARLHHYDE
Sbjct: 181 EPYSEPYADYGGLQEHVYEEIGDAPELDARDGLRLYEQERDEAAAYRQEALGARLHHYDE 240
Query: 241 RSDGESDSPEKEAEFAPYPRMDSYEQEEDIDQIVAEVKQSMSSQSLDKAAEDMPEAEQDL 300
RSDGESDSPEKEAEFAPYPRMDSYEQEEDIDQIVAEVKQSMSSQSLDKAAEDMPEAEQDL
Sbjct: 241 RSDGESDSPEKEAEFAPYPRMDSYEQEEDIDQIVAEVKQSMSSQSLDKAAEDMPEAEQDL 300
Query: 301 ERPPTPAGGRPDSPGLQAPAGQQRAVGPAGGGEAGQRYSKEKRDAISLAIKDIKEAIEEV 360
ERPPTPAGGRPDSPGLQAPAGQQRAVGPAGGGEAGQRYSKEKRDAISLAIKDIKEAIEEV
Sbjct: 301 ERPPTPAGGRPDSPGLQAPAGQQRAVGPAGGGEAGQRYSKEKRDAISLAIKDIKEAIEEV 360
Query: 361 KTRTIRSPYTPDEPKEPIWVMRQDISPTRDCDDQRPMDGDSPSPGSSSPLGAESSSTSLH 420
KTRTIRSPYTPDEPKEPIWVMRQDISPTRDCDDQRPMDGDSPSPGSSSPLGAESSSTSLH
Sbjct: 361 KTRTIRSPYTPDEPKEPIWVMRQDISPTRDCDDQRPMDGDSPSPGSSSPLGAESSSTSLH 420
Query: 421 PSDPVEASTNKESRKSLASFPTYVEVPGPCDPEDLIDGIIFAANYLGSTQLLSDKTPSKN 480
PSDPVEASTNKESRKSLASFPTYVEVPGPCDPEDLIDGIIFAANYLGSTQLLSDKTPSKN
Sbjct: 421 PSDPVEASTNKESRKSLASFPTYVEVPGPCDPEDLIDGIIFAANYLGSTQLLSDKTPSKN 480
Query: 481 VRMMQAQEAVSRIKMAQKLAKSRKKAPEGESQPMTEVDLFISTQRIKVLNADTQETMMDH 540
VRMMQAQEAVSRIKMAQKLAKSRKKAPEGESQPMTEVDLFISTQRIKVLNADTQETMMDH
Sbjct: 481 VRMMQAQEAVSRIKMAQKLAKSRKKAPEGESQPMTEVDLFISTQRIKVLNADTQETMMDH 540
Query: 541 PLRTISYIADIGNIVVLMARRRMPRSNSQENVEASHPSQDGKRQYKMICHVFESEDAQLI 600
PLRTISYIADIGNIVVLMARRRMPRSNSQENVEASHPSQDGKRQYKMICHVFESEDAQLI
Sbjct: 541 PLRTISYIADIGNIVVLMARRRMPRSNSQENVEASHPSQDGKRQYKMICHVFESEDAQLI 600
Query: 601 AQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDLLNTQDMYNDDLIHFSKSENCKDVFIE 660
AQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDLLNTQDMYNDDLIHFSKSENCKDVFIE
Sbjct: 601 AQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDLLNTQDMYNDDLIHFSKSENCKDVFIE 660
Query: 661 KQKGEILGVVIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLS 720
KQKGEILGVVIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLS
Sbjct: 661 KQKGEILGVVIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLS 720
Query: 721 TCQSIIKGLKNQSRVKLNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERG 780
TCQSIIKGLKNQSRVKLNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERG
Sbjct: 721 TCQSIIKGLKNQSRVKLNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERG 780
Query: 781 GVRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI 837
GVRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI
Sbjct: 781 GVRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI 837
>gi|22035550 amyloid beta A4 precursor protein-binding, family A,
member 2 isoform a [Homo sapiens]
Length = 749
Score = 719 bits (1855), Expect = 0.0
Identities = 433/814 (53%), Positives = 520/814 (63%), Gaps = 101/814 (12%)
Query: 33 EVEEEQQQPPQQQHYVGRHQRGRALEDLRAQLGQEEEERGECLARSASTESGFHNHTDTA 92
E E E + P + G G L LR + EE+ EC S +S +T+
Sbjct: 28 EPESEDMELPLE----GYVPEGLELAALRPESPAPEEQ--ECHNHSPDGDSSSDYVNNTS 81
Query: 93 EGDVIAAARDGYDAERAQDPEDESAYAVQYRPEAEEYTEQAEAEHAEATHRRALPNHLHF 152
E + YD E + E+ Y ++Y PE + Y E + E A
Sbjct: 82 E-------EEDYD-EGLPEEEEGITYYIRYCPEDDSYLEGMDCNGEEYLAHSA------- 126
Query: 153 HSLEHEEAMNAAYSGYVYTHRLFHRGEDEPYSEPYADYGGLQEHVYEEIGDAPELDARDG 212
H ++ +E A E + D G H +E G D +
Sbjct: 127 HPVDTDECQEAV--------------------EEWTDSAGPHPHGHEAEGSQDYPDGQ-- 164
Query: 213 LRLYEQERDEAAAYRQEALGARLHHYDERSDGESDSPEKEAE----FAPYPRM----DSY 264
L + E E A+ QE G HY +G D +EA +PY D
Sbjct: 165 LPIPEDEPSVLEAHDQEEDG----HYCASKEGYQDYYPEEANGNTGASPYRLRRGDGDLE 220
Query: 265 EQEEDIDQIVAEVKQSMSSQSLDKAAEDMPEAEQDLERPPTPAGGRPDSPGLQAPAGQQR 324
+QEEDIDQIVAE+K S+S S+ A+E PE + P P P ++A
Sbjct: 221 DQEEDIDQIVAEIKMSLSMTSITSASEASPEHGPE----PGPEDSVEACPPIKASC---- 272
Query: 325 AVGPAGGGEAGQRYSKEKRDAISLAIKDIKEAIEEVKTRTIRSPYTPDEPKEPIWVMRQD 384
S + +A ++ + EA + P P +P
Sbjct: 273 --------------SPSRHEARPKSLNLLPEA---------KHPGDPQRGFKP------- 302
Query: 385 ISPTRDCDDQRPMDGDSPSPGSSSPLGAESSSTSLHPSDPVEASTNKESRKSLASFPTYV 444
TR +++ + G P + S + PV+ + E++K +ASFP++V
Sbjct: 303 --KTRTPEERLKWPHEQVCNGLEQPRKQQRSDLN----GPVDNNNIPETKK-VASFPSFV 355
Query: 445 EVPGPCDPEDLIDGIIFAANYLGSTQLLSDKTPSKNVRMMQAQEAVSRIKMAQKLAKSRK 504
VPGPC+PEDLIDGIIFAANYLGSTQLLS++ PSKN+RMMQAQEAVSR+K QK AK +K
Sbjct: 356 AVPGPCEPEDLIDGIIFAANYLGSTQLLSERNPSKNIRMMQAQEAVSRVKRMQKAAKIKK 415
Query: 505 KA-PEGESQPMTEVDLFISTQRIKVLNADTQETMMDHPLRTISYIADIGNIVVLMARRRM 563
KA EG++Q +TEVDLFISTQRIKVLNADTQETMMDH LRTISYIADIGNIVVLMARRRM
Sbjct: 416 KANSEGDAQTLTEVDLFISTQRIKVLNADTQETMMDHALRTISYIADIGNIVVLMARRRM 475
Query: 564 PRSNSQENVEASHPSQDGKRQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINP 623
PRS SQ+ +E + +Q+GK+QYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINP
Sbjct: 476 PRSASQDCIETTPGAQEGKKQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINP 535
Query: 624 EDLSQKEYSDLLNTQDMYNDDLIHFSKSENCKDVFIEKQKGEILGVVIVESGWGSILPTV 683
EDLSQKEYSD++NTQ+MYNDDLIHFS SENCK++ +EK KGEILGVV+VESGWGSILPTV
Sbjct: 536 EDLSQKEYSDIINTQEMYNDDLIHFSNSENCKELQLEKHKGEILGVVVVESGWGSILPTV 595
Query: 684 IIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVRCP 743
I+ANMM+GGPA +SGKL+IGDQIMSINGTSLVGLPL+TCQ IIKGLKNQ++VKLNIV CP
Sbjct: 596 ILANMMNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCP 655
Query: 744 PVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATPHEK 803
PVTTVLI+RPDL+YQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVAT HEK
Sbjct: 656 PVTTVLIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEK 715
Query: 804 IVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI 837
IV LSN+VGEIHMKTMPAAM+RLLT QE P+YI
Sbjct: 716 IVQALSNSVGEIHMKTMPAAMFRLLTGQETPLYI 749
>gi|194353992 amyloid beta A4 precursor protein-binding, family A,
member 2 isoform b [Homo sapiens]
Length = 737
Score = 703 bits (1815), Expect = 0.0
Identities = 426/813 (52%), Positives = 513/813 (63%), Gaps = 111/813 (13%)
Query: 33 EVEEEQQQPPQQQHYVGRHQRGRALEDLRAQLGQEEEERGECLARSASTESGFHNHTDTA 92
E E E + P + G G L LR + EE+ EC S +S +T+
Sbjct: 28 EPESEDMELPLE----GYVPEGLELAALRPESPAPEEQ--ECHNHSPDGDSSSDYVNNTS 81
Query: 93 EGDVIAAARDGYDAERAQDPEDESAYAVQYRPEAEEYTEQAEAEHAEATHRRALPNHLHF 152
E + YD E + E+ Y ++Y PE + Y E + E A
Sbjct: 82 E-------EEDYD-EGLPEEEEGITYYIRYCPEDDSYLEGMDCNGEEYLAHSA------- 126
Query: 153 HSLEHEEAMNAAYSGYVYTHRLFHRGEDEPYSEPYADYGGLQEHVYEEIGDAPELDARDG 212
H ++ +E A E + D G H +E G D +
Sbjct: 127 HPVDTDECQEAV--------------------EEWTDSAGPHPHGHEAEGSQDYPDGQ-- 164
Query: 213 LRLYEQERDEAAAYRQEALGARLHHYDERSDGESDSPEKEAE----FAPYPRM----DSY 264
L + E E A+ QE G HY +G D +EA +PY D
Sbjct: 165 LPIPEDEPSVLEAHDQEEDG----HYCASKEGYQDYYPEEANGNTGASPYRLRRGDGDLE 220
Query: 265 EQEEDIDQIVAEVKQSMSSQSLDKAAEDMPEAEQDLERPPTPAGGRPDSPGLQAPAGQQR 324
+QEEDIDQIVAE+K S+S S+ A+E PE + P P P ++A
Sbjct: 221 DQEEDIDQIVAEIKMSLSMTSITSASEASPEHGPE----PGPEDSVEACPPIKASC---- 272
Query: 325 AVGPAGGGEAGQRYSKEKRDAISLAIKDIKEAIEEVKTRTIRSPYTPDEPKEPIWVMRQD 384
S + +A ++ + EA + P P +P
Sbjct: 273 --------------SPSRHEARPKSLNLLPEA---------KHPGDPQRGFKP------- 302
Query: 385 ISPTRDCDDQRPMDGDSPSPGSSSPLGAESSSTSLHPSDPVEASTNKESRKSLASFPTYV 444
TR +++ + G P + S + PV+ + E++K +ASFP++V
Sbjct: 303 --KTRTPEERLKWPHEQVCNGLEQPRKQQRSDLN----GPVDNNNIPETKK-VASFPSFV 355
Query: 445 EVPGPCDPEDLIDGIIFAANYLGSTQLLSDKTPSKNVRMMQAQEAVSRIKMAQKLAKSRK 504
VPGPC+PEDLIDGIIFAANYLGSTQLLS++ PSKN+RMMQAQEAVSR+K +
Sbjct: 356 AVPGPCEPEDLIDGIIFAANYLGSTQLLSERNPSKNIRMMQAQEAVSRVKNS-------- 407
Query: 505 KAPEGESQPMTEVDLFISTQRIKVLNADTQETMMDHPLRTISYIADIGNIVVLMARRRMP 564
EG++Q +TEVDLFISTQRIKVLNADTQETMMDH LRTISYIADIGNIVVLMARRRMP
Sbjct: 408 ---EGDAQTLTEVDLFISTQRIKVLNADTQETMMDHALRTISYIADIGNIVVLMARRRMP 464
Query: 565 RSNSQENVEASHPSQDGKRQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPE 624
RS SQ+ +E + +Q+GK+QYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPE
Sbjct: 465 RSASQDCIETTPGAQEGKKQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPE 524
Query: 625 DLSQKEYSDLLNTQDMYNDDLIHFSKSENCKDVFIEKQKGEILGVVIVESGWGSILPTVI 684
DLSQKEYSD++NTQ+MYNDDLIHFS SENCK++ +EK KGEILGVV+VESGWGSILPTVI
Sbjct: 525 DLSQKEYSDIINTQEMYNDDLIHFSNSENCKELQLEKHKGEILGVVVVESGWGSILPTVI 584
Query: 685 IANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVRCPP 744
+ANMM+GGPA +SGKL+IGDQIMSINGTSLVGLPL+TCQ IIKGLKNQ++VKLNIV CPP
Sbjct: 585 LANMMNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCPP 644
Query: 745 VTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATPHEKI 804
VTTVLI+RPDL+YQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVAT HEKI
Sbjct: 645 VTTVLIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEKI 704
Query: 805 VHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI 837
V LSN+VGEIHMKTMPAAM+RLLT QE P+YI
Sbjct: 705 VQALSNSVGEIHMKTMPAAMFRLLTGQETPLYI 737
>gi|11342678 amyloid beta (A4) precursor protein-binding, family A,
member 3 [Homo sapiens]
Length = 575
Score = 514 bits (1324), Expect = e-145
Identities = 270/477 (56%), Positives = 343/477 (71%), Gaps = 39/477 (8%)
Query: 371 PDEPKEPIWVMRQDISPTRDCDDQRPMDGDSPS---PGSSSPLGAESSSTSLHP------ 421
P+EP EP + Q P D D+ D DSP S+ G+ SSS+S P
Sbjct: 128 PEEPLEPAPRLLQ---PPEDPDE----DSDSPEWVEGASAEQEGSRSSSSSPEPWLETVP 180
Query: 422 -SDPVEASTNKESRKSLASFPTYVEVPGPCDPEDLIDGIIFAANYLGSTQLLSDKTPSKN 480
P E +S ++LAS+P EVPGPCD EDL+DG+IF A YLGSTQL+S++ P +
Sbjct: 181 LVTPEEPPAGAQSPETLASYPAPQEVPGPCDHEDLLDGVIFGARYLGSTQLVSERNPPTS 240
Query: 481 VRMMQAQEAVSRIKMAQKLAKSRKKAPEGESQPMTEVDLFISTQRIKVLNADTQETMMDH 540
RM QA+EA+ R+K AP+GE+QPMTEVDLF+ST+RIKVL AD+QE MMDH
Sbjct: 241 TRMAQAREAMDRVK-----------APDGETQPMTEVDLFVSTKRIKVLTADSQEAMMDH 289
Query: 541 PLRTISYIADIGNIVVLMARRRMPRSNSQENVEASHPSQDGKRQYKMICHVFESEDAQLI 600
L TISY ADIG ++VLMARRR+ R + P G+R YKM+CHVF +EDAQLI
Sbjct: 290 ALHTISYTADIGCVLVLMARRRLARRPA--------PQDHGRRLYKMLCHVFYAEDAQLI 341
Query: 601 AQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDLLNTQDMYNDDLIHFSKSENCKDVFIE 660
AQ+IGQAF+ AY +FLR +GI+P SQ ++N DL HFS S+NC++V +E
Sbjct: 342 AQAIGQAFAAAYSQFLRESGIDP---SQVGVHPSPGACHLHNGDLDHFSNSDNCREVHLE 398
Query: 661 KQKGEILGVVIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLS 720
K++GE LGV +VESGWGS+LPT +IAN++HGGPAE+SG L+IGD++ +INGTSLVGLPL+
Sbjct: 399 KRRGEGLGVALVESGWGSLLPTAVIANLLHGGPAERSGALSIGDRLTAINGTSLVGLPLA 458
Query: 721 TCQSIIKGLKNQSRVKLNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERG 780
CQ+ ++ K+Q+ V L+IV CPPVTT +I RP R QLGF V++GIICSL+RGGIAERG
Sbjct: 459 ACQAAVRETKSQTSVTLSIVHCPPVTTAIIHRPHAREQLGFCVEDGIICSLLRGGIAERG 518
Query: 781 GVRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI 837
G+RVGHRIIEINGQSVVATPH +I+ +L+ A GE+H+KTMPAA YRLLT QEQPVY+
Sbjct: 519 GIRVGHRIIEINGQSVVATPHARIIELLTEAYGEVHIKTMPAATYRLLTGQEQPVYL 575
>gi|134152672 syndecan binding protein 2 isoform a [Homo sapiens]
Length = 292
Score = 67.4 bits (163), Expect = 5e-11
Identities = 40/145 (27%), Positives = 69/145 (47%), Gaps = 3/145 (2%)
Query: 693 PAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVRCPPVTTVLIRR 752
PA G L GDQ++ I+G G ++K V +VR P +
Sbjct: 140 PASLVG-LRFGDQLLQIDGRDCAGWSSHKAHQVVKKASGDKIVV--VVRDRPFQRTVTMH 196
Query: 753 PDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATPHEKIVHILSNAV 812
D +GF ++ G I SL++G A R G+ H + E++GQ+V+ +KI+ IL+ A
Sbjct: 197 KDSMGHVGFVIKKGKIVSLVKGSSAARNGLLTNHYVCEVDGQNVIGLKDKKIMEILATAG 256
Query: 813 GEIHMKTMPAAMYRLLTAQEQPVYI 837
+ + +P+ +Y + + PV +
Sbjct: 257 NVVTLTIIPSVIYEHMVKKLPPVLL 281
>gi|38016916 syndecan binding protein 2 isoform b [Homo sapiens]
Length = 207
Score = 67.4 bits (163), Expect = 5e-11
Identities = 40/145 (27%), Positives = 69/145 (47%), Gaps = 3/145 (2%)
Query: 693 PAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVRCPPVTTVLIRR 752
PA G L GDQ++ I+G G ++K V +VR P +
Sbjct: 55 PASLVG-LRFGDQLLQIDGRDCAGWSSHKAHQVVKKASGDKIVV--VVRDRPFQRTVTMH 111
Query: 753 PDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATPHEKIVHILSNAV 812
D +GF ++ G I SL++G A R G+ H + E++GQ+V+ +KI+ IL+ A
Sbjct: 112 KDSMGHVGFVIKKGKIVSLVKGSSAARNGLLTNHYVCEVDGQNVIGLKDKKIMEILATAG 171
Query: 813 GEIHMKTMPAAMYRLLTAQEQPVYI 837
+ + +P+ +Y + + PV +
Sbjct: 172 NVVTLTIIPSVIYEHMVKKLPPVLL 196
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 64.7 bits (156), Expect = 3e-10
Identities = 91/371 (24%), Positives = 149/371 (40%), Gaps = 34/371 (9%)
Query: 9 EVEVTDEAAGGEVNESVEAD----LEHPEVEEEQQQPPQQQHYVGRHQRGRALE-DLRAQ 63
E + EAA G + ++D +E PE E E Q P+ + G A E + AQ
Sbjct: 1811 EDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQ--PESEGVEAPEAEGDAQEAEGEAQ 1868
Query: 64 LGQEE----EERGECLARSASTESGFHNHTDTAEGDVIAAAR--DGYDAERAQDPEDESA 117
E+ E GE S E T AE +V + + +AE+ PE ES
Sbjct: 1869 PESEDVEAPEAEGEAQPESEDVE------TPEAEWEVQPESEGAEAPEAEKEAQPETESV 1922
Query: 118 YAVQYRPEAEEYTEQAEAEHAEATHRRA----LPNHLHFHSLEHEEAMNAAYSGY----V 169
A++ E E +E AEA+ AE + A P S E EE V
Sbjct: 1923 EALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEV 1982
Query: 170 YTHRLFHRGEDEPYSE----PYADYGGLQEHVYEEIGDAPELDARDGLRLYEQERDEAAA 225
GE +P SE P A+ G +QE E ++ ++A+ E + E
Sbjct: 1983 EVETQEAEGEAQPESEDVEAPEAE-GEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGET 2041
Query: 226 YRQEALGARLHHYDERSDGESDSPEKEAEFAPYPRMDSYEQEEDIDQIVAEVKQSMSSQS 285
+ E E + E ++ E E E +++ + ED+D AE + S+
Sbjct: 2042 QKTEGDAQPESDGVEAPEAEEEAQEAEGE-VQEAEGEAHPESEDVDAQEAEGEAQPESEG 2100
Query: 286 LD-KAAEDMPEAEQDLERPPTPAGGRPDSPGLQAPAGQQRAVGPAGGGEAGQRYSKEKRD 344
++ AE + + +E P T +P+S G++AP + A + G EA + + +
Sbjct: 2101 VEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPE 2160
Query: 345 AISLAIKDIKE 355
+ + ++ +E
Sbjct: 2161 SEGIEAQEAEE 2171
Score = 54.3 bits (129), Expect = 5e-07
Identities = 106/513 (20%), Positives = 193/513 (37%), Gaps = 69/513 (13%)
Query: 14 DEAAGGEVNESVEADLEHPEVEEEQQQPPQQQHYVGRHQRGRALEDLRAQLGQEEEERGE 73
DE GE ++ + D + P++ E + Q+ H + ++LG+ E+E GE
Sbjct: 1741 DEGEDGEGSQRLNRDKD-PKLGEAEGDAMAQEREGKTHNSETSAG---SELGEAEQE-GE 1795
Query: 74 CLARSASTESGFHNHTDTAEGDVIAAARDGYDAERAQDPEDESAYAVQYRPEAEEYTEQA 133
++ T H D +G+ A G D + Q E A + EA+ +E
Sbjct: 1796 GISERGETGGQGSGHEDNLQGEAAA----GGDQDPGQSDGAEGIEAPEAEGEAQPESEGV 1851
Query: 134 EAEHAEATHRRALPN-HLHFHSLEHEEAMNAAYSGYVYTHRLFHRGEDEPYSEPYADYGG 192
EA AE + A +E EA A + E E P A++
Sbjct: 1852 EAPEAEGDAQEAEGEAQPESEDVEAPEAEGEA------------QPESEDVETPEAEWEV 1899
Query: 193 LQEHVYEEIGDA-----PELDARDGLRLY-EQERDEAAAYRQEALGARLHHYDERSDGES 246
E E +A PE ++ + L E E + A QEA A + ++G++
Sbjct: 1900 QPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAA-----QEAEGQT 1954
Query: 247 DSPEKEAEFAPYPRMDSYEQEEDIDQIVAEVKQSMSSQSLDKAAEDM--PEAEQDLERPP 304
PE E + ++ + ED++ + EV+ + +ED+ PEAE +++
Sbjct: 1955 -QPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAE 2013
Query: 305 TPAGGRPDSPGLQAPAGQQRAVGPAGGGEAGQRYSKEKRDAISLAIKDIKEAIEEVKTRT 364
A +P+S G++A P GE Q E + E + ++
Sbjct: 2014 EEA--QPESDGVEAQ--------PKSEGEEAQEVEGETQKT---------EGDAQPESDG 2054
Query: 365 IRSPYTPDEPKEPIW-VMRQDISPTRDCDDQRPMDGDSPSPGSSSPLGAESSSTSLHPSD 423
+ +P +E +E V + + +D + + + S + A + ++
Sbjct: 2055 VEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAE 2114
Query: 424 PVEASTNKESRKSLASFPTYVEVPGPCDPEDLIDGIIFAANYLGSTQLLSDKTPSKNVRM 483
+EA + + + E G PE +G + A + G Q S+ +
Sbjct: 2115 GIEAPETEGEAQPESEGIEAPEAEGEAQPES--EG-VEAQDAEGEAQ-----PESEGIEA 2166
Query: 484 MQAQEAVSRIKMAQKLAKSRKKAPEGESQPMTE 516
+A+E + +L EGE+QP +E
Sbjct: 2167 QEAEE-----EAQPELEGVEAPEAEGEAQPESE 2194
Score = 52.8 bits (125), Expect = 1e-06
Identities = 102/427 (23%), Positives = 164/427 (38%), Gaps = 42/427 (9%)
Query: 8 AEVEVTDEAAGGEVNESV-EADLEHPEVEEEQQQPPQQQHYVGRHQRGRALEDLRAQLGQ 66
AE EV E+ G E E+ EA E VE + + + G + A E + GQ
Sbjct: 1895 AEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQ-EAEEAAQEAEGQ 1953
Query: 67 EEEERGECLARSASTESGFHNHTDTAEGDVIAAARDGYDAERAQDPEDESAYAVQYRPEA 126
+ E ++ A E+ ++ + + + + +AE PE E A PEA
Sbjct: 1954 TQPESEVIESQEAEEEA----QPESEDVEALEVEVETQEAEGEAQPESEDVEA----PEA 2005
Query: 127 EEYTEQAEAE-HAEATHRRALPNHLHFHSLEHEEAMNAAYSGYVYTHRLFHRGEDEPYSE 185
E ++AE E E+ A P E EEA G + E +
Sbjct: 2006 EGEMQEAEEEAQPESDGVEAQPKS------EGEEAQEV--EGETQKTEGDAQPESDGVEA 2057
Query: 186 PYADY------GGLQEHVYEEIGDAPELDARD--GLRLYEQERDEAAAYRQEALGARLHH 237
P A+ G +QE E ++ ++DA++ G E E EA EA A
Sbjct: 2058 PEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIE 2117
Query: 238 YDERSDGESDSPEKEAEFAPYPRMDSYEQEEDIDQIVAEVKQSMSSQSLDKAAEDMPEAE 297
E ++GE+ PE E AP ++ + E ++ AE + S+ ++ A E EA+
Sbjct: 2118 APE-TEGEAQ-PESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIE-AQEAEEEAQ 2174
Query: 298 QDLE---RPPTPAGGRPDSPGLQAPAGQQRAVGPAGGGEAGQRYSKEKRDAISLAIKDIK 354
+LE P +P+S G++AP + A G EA + + + + + ++
Sbjct: 2175 PELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEP-----EGVE 2229
Query: 355 EAIEEVKTRTIRSPYTPDEPKEPIWVMRQDISPTRDCDDQRPMDGD----SPSPGSSSPL 410
E + + T E K V D + P+ D PSPG +P
Sbjct: 2230 TPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPH 2289
Query: 411 GAESSST 417
S T
Sbjct: 2290 QRPGSQT 2296
>gi|55749523 syntenin isoform 3 [Homo sapiens]
Length = 297
Score = 62.4 bits (150), Expect = 2e-09
Identities = 41/152 (26%), Positives = 70/152 (46%), Gaps = 3/152 (1%)
Query: 683 VIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVRC 742
+ + + PA G L GDQ++ ING + G ++K + ++ + I R
Sbjct: 135 IFVQLVQANSPASLVG-LRFGDQVLQINGENCAGWSSDKAHKVLKQAFGE-KITMTI-RD 191
Query: 743 PPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATPHE 802
P + D +GF +NG I S+++ A R G+ H I EINGQ+V+
Sbjct: 192 RPFERTITMHKDSTGHVGFIFKNGKITSIVKDSSAARNGLLTEHNICEINGQNVIGLKDS 251
Query: 803 KIVHILSNAVGEIHMKTMPAAMYRLLTAQEQP 834
+I ILS + + + MPA ++ + + P
Sbjct: 252 QIADILSTSGTVVTITIMPAFIFEHIIKRMAP 283
>gi|55749515 syntenin isoform 3 [Homo sapiens]
Length = 297
Score = 62.4 bits (150), Expect = 2e-09
Identities = 41/152 (26%), Positives = 70/152 (46%), Gaps = 3/152 (1%)
Query: 683 VIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVRC 742
+ + + PA G L GDQ++ ING + G ++K + ++ + I R
Sbjct: 135 IFVQLVQANSPASLVG-LRFGDQVLQINGENCAGWSSDKAHKVLKQAFGE-KITMTI-RD 191
Query: 743 PPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATPHE 802
P + D +GF +NG I S+++ A R G+ H I EINGQ+V+
Sbjct: 192 RPFERTITMHKDSTGHVGFIFKNGKITSIVKDSSAARNGLLTEHNICEINGQNVIGLKDS 251
Query: 803 KIVHILSNAVGEIHMKTMPAAMYRLLTAQEQP 834
+I ILS + + + MPA ++ + + P
Sbjct: 252 QIADILSTSGTVVTITIMPAFIFEHIIKRMAP 283
>gi|55749504 syntenin isoform 2 [Homo sapiens]
Length = 292
Score = 62.4 bits (150), Expect = 2e-09
Identities = 41/152 (26%), Positives = 70/152 (46%), Gaps = 3/152 (1%)
Query: 683 VIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVRC 742
+ + + PA G L GDQ++ ING + G ++K + ++ + I R
Sbjct: 130 IFVQLVQANSPASLVG-LRFGDQVLQINGENCAGWSSDKAHKVLKQAFGE-KITMTI-RD 186
Query: 743 PPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATPHE 802
P + D +GF +NG I S+++ A R G+ H I EINGQ+V+
Sbjct: 187 RPFERTITMHKDSTGHVGFIFKNGKITSIVKDSSAARNGLLTEHNICEINGQNVIGLKDS 246
Query: 803 KIVHILSNAVGEIHMKTMPAAMYRLLTAQEQP 834
+I ILS + + + MPA ++ + + P
Sbjct: 247 QIADILSTSGTVVTITIMPAFIFEHIIKRMAP 278
>gi|55749490 syntenin isoform 1 [Homo sapiens]
Length = 298
Score = 62.4 bits (150), Expect = 2e-09
Identities = 41/152 (26%), Positives = 70/152 (46%), Gaps = 3/152 (1%)
Query: 683 VIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVRC 742
+ + + PA G L GDQ++ ING + G ++K + ++ + I R
Sbjct: 136 IFVQLVQANSPASLVG-LRFGDQVLQINGENCAGWSSDKAHKVLKQAFGE-KITMTI-RD 192
Query: 743 PPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATPHE 802
P + D +GF +NG I S+++ A R G+ H I EINGQ+V+
Sbjct: 193 RPFERTITMHKDSTGHVGFIFKNGKITSIVKDSSAARNGLLTEHNICEINGQNVIGLKDS 252
Query: 803 KIVHILSNAVGEIHMKTMPAAMYRLLTAQEQP 834
+I ILS + + + MPA ++ + + P
Sbjct: 253 QIADILSTSGTVVTITIMPAFIFEHIIKRMAP 284
>gi|56243522 syntenin isoform 1 [Homo sapiens]
Length = 298
Score = 62.4 bits (150), Expect = 2e-09
Identities = 41/152 (26%), Positives = 70/152 (46%), Gaps = 3/152 (1%)
Query: 683 VIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVRC 742
+ + + PA G L GDQ++ ING + G ++K + ++ + I R
Sbjct: 136 IFVQLVQANSPASLVG-LRFGDQVLQINGENCAGWSSDKAHKVLKQAFGE-KITMTI-RD 192
Query: 743 PPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATPHE 802
P + D +GF +NG I S+++ A R G+ H I EINGQ+V+
Sbjct: 193 RPFERTITMHKDSTGHVGFIFKNGKITSIVKDSSAARNGLLTEHNICEINGQNVIGLKDS 252
Query: 803 KIVHILSNAVGEIHMKTMPAAMYRLLTAQEQP 834
+I ILS + + + MPA ++ + + P
Sbjct: 253 QIADILSTSGTVVTITIMPAFIFEHIIKRMAP 284
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 60.1 bits (144), Expect = 8e-09
Identities = 71/295 (24%), Positives = 117/295 (39%), Gaps = 79/295 (26%)
Query: 611 AYQEFLRANGINPEDLSQKEYSDLLNTQD------MYNDDLIHFSKSENCK--DVFIEKQ 662
A + L NG++ + S +E L +Y D+ H+ EN + V ++K+
Sbjct: 1481 AGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDEA-HYRDEENLEIFPVDLQKK 1539
Query: 663 KGEILGVVIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTC 722
G LG+ IV GS V I++++ GG A+ G+L GDQI+S+NG + T
Sbjct: 1540 AGRGLGLSIVGKRNGS---GVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETV 1596
Query: 723 QSIIKGLKNQSRVKLNIVR-----------------------------CPPVT------- 746
+I+K + ++++ +R P +T
Sbjct: 1597 ATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVG 1656
Query: 747 -------------------TVLIRRPDLRYQLGFSVQNG----------IICSLMRGGIA 777
TV I R +L LG S+ G I + G+A
Sbjct: 1657 TKRVSDPSQKNSGTDMEPRTVEINR-ELSDALGISIAGGRGSPLGDIPVFIAMIQASGVA 1715
Query: 778 ER-GGVRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQ 831
R ++VG RI+ INGQ + H +V++L NA G I ++ + + AQ
Sbjct: 1716 ARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVADTNISAIAAQ 1770
Score = 45.4 bits (106), Expect = 2e-04
Identities = 51/181 (28%), Positives = 88/181 (48%), Gaps = 21/181 (11%)
Query: 655 KDVFIEKQKGEI-LGVVIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTS 713
+++ IE KG LG+ IV G + L ++I + G A + G+L GDQI+ +NG
Sbjct: 1434 QEMIIEISKGRSGLGLSIV-GGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNG-- 1490
Query: 714 LVGLPLSTCQSIIKGLK-NQSRVKLNIVR----CPPVTTVLIRRPDLRYQ----LGFSV- 763
V L S+ + I L+ +V+L + R + I DL+ + LG S+
Sbjct: 1491 -VDLRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIV 1549
Query: 764 --QNG---IICSLMRGGIAERGGVRV-GHRIIEINGQSVVATPHEKIVHILSNAVGEIHM 817
+NG I +++GG A+ G + G +I+ +NG+ + E + IL A G + +
Sbjct: 1550 GKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQL 1609
Query: 818 K 818
+
Sbjct: 1610 E 1610
Score = 40.0 bits (92), Expect = 0.009
Identities = 33/110 (30%), Positives = 56/110 (50%), Gaps = 7/110 (6%)
Query: 655 KDVFIEKQKGEILGVVIVESGWGSILPT--VIIANMMHGGPAEKSGKLNIGDQIMSINGT 712
+ V I ++ + LG+ I G GS L V IA + G A ++ KL +GD+I+SING
Sbjct: 1675 RTVEINRELSDALGISIA-GGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQ 1733
Query: 713 SLVGLPLSTCQSIIKGLKNQSRVKLNIVRCPPVTTVLIRRPDLR--YQLG 760
L GL + +++K R+ L +V ++ + + ++ Y LG
Sbjct: 1734 PLDGLSHADVVNLLKNA--YGRIILQVVADTNISAIAAQLENMSTGYHLG 1781
Score = 38.5 bits (88), Expect = 0.026
Identities = 36/178 (20%), Positives = 73/178 (41%), Gaps = 43/178 (24%)
Query: 683 VIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKL----- 737
V++ ++ GG A++ G+L GD I+ I GT++ G+ +++ N R+ +
Sbjct: 270 VVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPA 329
Query: 738 -NIVRCPPVTTVL-IRRPDLR-----------------------YQLGFSV--------- 763
+I PP L + P + LG +
Sbjct: 330 GDISVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHT 389
Query: 764 --QNGI-ICSLMRGGIA-ERGGVRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHM 817
+GI + S++ G A G ++V +I+ ++G ++ + +V +L NA +H+
Sbjct: 390 GEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHL 447
Score = 35.4 bits (80), Expect = 0.22
Identities = 19/60 (31%), Positives = 31/60 (51%), Gaps = 2/60 (3%)
Query: 682 TVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVR 741
++ + + GPA G++ IGD+++ IN L G +IIK S+VKL +R
Sbjct: 1263 SIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIK--TAPSKVKLVFIR 1320
Score = 31.2 bits (69), Expect = 4.2
Identities = 19/68 (27%), Positives = 30/68 (44%), Gaps = 12/68 (17%)
Query: 685 IANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVRCPP 744
I++++ GGP + G L D+++ +NG L G S +K + PP
Sbjct: 583 ISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVP------------PP 630
Query: 745 VTTVLIRR 752
T V RR
Sbjct: 631 FTLVCCRR 638
Score = 30.8 bits (68), Expect = 5.4
Identities = 15/47 (31%), Positives = 28/47 (59%)
Query: 683 VIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGL 729
++I +++ G AE+SG L GD+++S+N L L+ I+K +
Sbjct: 714 IVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAV 760
Score = 30.4 bits (67), Expect = 7.1
Identities = 16/55 (29%), Positives = 24/55 (43%)
Query: 677 GSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKN 731
G L + I ++ PA K+ L GD+I+ ++G L S IK N
Sbjct: 1096 GEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGN 1150
>gi|7705318 GULP, engulfment adaptor PTB domain containing 1 [Homo
sapiens]
Length = 304
Score = 57.4 bits (137), Expect = 5e-08
Identities = 49/171 (28%), Positives = 82/171 (47%), Gaps = 31/171 (18%)
Query: 459 IIFAANYLGSTQLLSDKTPSKNVRMMQAQEAVSRIKMAQKLAKSRKKAPEGESQPMTEVD 518
I + A +LGST++ K ++AV ++K A+ + KS E Q + +V+
Sbjct: 25 IPYNAKFLGSTEVEQPKGTEV------VRDAVRKLKFARHIKKS-------EGQKIPKVE 71
Query: 519 LFISTQRIKVLNADTQETMMDHPLRTISYIADIGNIVVLMARRRMPRSNSQENVEASHPS 578
L IS +K+L T+E + L IS+ AD +++ + S
Sbjct: 72 LQISIYGVKILEPKTKEVQHNCQLHRISFCAD-------------DKTDKRIFTFICKDS 118
Query: 579 QDGKRQYKMICHVFESED-AQLIAQSIGQAFSVAYQEFLRANGINPEDLSQ 628
+ K +C+VF+SE A+ I +IGQAF +AY++FL + G + E Q
Sbjct: 119 ESNKH----LCYVFDSEKCAEEITLTIGQAFDLAYRKFLESGGKDVETRKQ 165
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 57.4 bits (137), Expect = 5e-08
Identities = 65/263 (24%), Positives = 111/263 (42%), Gaps = 46/263 (17%)
Query: 611 AYQEFLRANGINPEDLSQKEYSDLLNTQD------MYNDDLIHFSKSENCKDVFIEKQK- 663
A + L NGI+ + E ++L +Y D+ + + E C + IE QK
Sbjct: 1673 AGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEA-PYKEEEVCDTLTIELQKK 1731
Query: 664 -GEILGVVIVESGWGSILPT-VIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLST 721
G+ LG+ IV G T V +++++ GG A+ G+L GDQI+ +NG +
Sbjct: 1732 PGKGLGLSIV----GKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEA 1787
Query: 722 CQSIIK--------------------GLKNQSRVKLNIVRCPPVTTVLIRRPDLRYQLGF 761
+++K L++ S+ + TV +++ LG
Sbjct: 1788 VAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTD-SLGI 1846
Query: 762 SVQNG---------IICSLMR--GGIAERGGVRVGHRIIEINGQSVVATPHEKIVHILSN 810
S+ G I ++M G A+ +RVG RI+ I G S H + V++L N
Sbjct: 1847 SIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKN 1906
Query: 811 AVGEIHMKTMPAAMYRLLTAQEQ 833
A G I M+ + ++T +Q
Sbjct: 1907 ASGSIEMQVVAGGDVSVVTGHQQ 1929
Score = 55.5 bits (132), Expect = 2e-07
Identities = 68/261 (26%), Positives = 114/261 (43%), Gaps = 29/261 (11%)
Query: 582 KRQYKMICHVFESEDAQLIAQSIGQAFSV---AYQEFLRANGINPEDLSQKEYSDLLNTQ 638
K K+ H E+ D+Q + + G A + Q + +PE S + S +T
Sbjct: 1553 KMTVKLTIHA-ENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRS-STP 1610
Query: 639 DMYNDDLIHFSKSENCKDVFIEKQKGEI-LGVVIVESGWGSILPTVIIANMMHGGPAEKS 697
++ D C+ IE KG LG+ IV G ++L +II + G A K
Sbjct: 1611 AIFASDPATCPIIPGCETT-IEISKGRTGLGLSIV-GGSDTLLGAIIIHEVYEEGAACKD 1668
Query: 698 GKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVR----------CPPVTT 747
G+L GDQI+ +NG L ++++ + RV+L + R C +T
Sbjct: 1669 GRLWAGDQILEVNGIDLRKATHDEAINVLR--QTPQRVRLTLYRDEAPYKEEEVCDTLTI 1726
Query: 748 VLIRRPDLRYQLGFSV-----QNGIICS-LMRGGIAERGG-VRVGHRIIEINGQSVVATP 800
L ++P LG S+ G+ S +++GGIA+ G + G +I+ +NG+ V
Sbjct: 1727 ELQKKPG--KGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNAT 1784
Query: 801 HEKIVHILSNAVGEIHMKTMP 821
E + +L + G + T P
Sbjct: 1785 QEAVAALLKVSEGSLSSFTFP 1805
Score = 50.4 bits (119), Expect = 7e-06
Identities = 59/221 (26%), Positives = 94/221 (42%), Gaps = 55/221 (24%)
Query: 649 SKSENCKDVFIEKQKGEILGVVIVESGWGSILPTV-IIANMMHG-GPAEKSGKLNIGDQI 706
S+ + + V ++K + LG+ I G GS L V I MMH G A ++ KL +GD+I
Sbjct: 1826 SEIQGLRTVEMKKGPTDSLGISIA-GGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRI 1884
Query: 707 MSINGTSLVGLPLSTCQSIIK----------------------------------GLKNQ 732
++I GTS G+ + +++K GL +
Sbjct: 1885 VTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSS 1944
Query: 733 SRVK--LNIVRCPPVTTVLIRRPDLRYQLGFSVQNG-----------IICSLMRGGIAER 779
S + L +C +T L R PD LGFS+ G + +G +E
Sbjct: 1945 SIFQDDLGPPQCKSIT--LERGPD---GLGFSIVGGYGSPHGDLPIYVKTVFAKGAASED 1999
Query: 780 GGVRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMKTM 820
G ++ G +II +NGQS+ HE+ V IL G + + +
Sbjct: 2000 GRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVL 2040
Score = 48.9 bits (115), Expect = 2e-05
Identities = 38/118 (32%), Positives = 58/118 (49%), Gaps = 10/118 (8%)
Query: 622 NPEDLSQKEYSDLLNTQDMYNDDLIHFSKSENCKDVFIEKQKGEILGVVIVESGWGSILP 681
N E+L KE + T D D S +N + + + K +G LG+ I E L
Sbjct: 1453 NSENLQNKETEPTVTTSDAAVD----LSSFKNVQHLELPKDQGG-LGIAISEE---DTLS 1504
Query: 682 TVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNI 739
VII ++ G A G+L +GDQI++++ +VG P+ S++K K VKL I
Sbjct: 1505 GVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAK--MTVKLTI 1560
Score = 40.4 bits (93), Expect = 0.007
Identities = 32/99 (32%), Positives = 51/99 (51%), Gaps = 10/99 (10%)
Query: 635 LNTQDMYNDDLIHFSKSENCKDVFIEKQKGEILGVVIVESGWGSI---LPTVIIANMMHG 691
L + ++ DDL CK + +E+ + LG IV G+GS LP + + +
Sbjct: 1941 LTSSSIFQDDL----GPPQCKSITLERGP-DGLGFSIV-GGYGSPHGDLP-IYVKTVFAK 1993
Query: 692 GPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLK 730
G A + G+L GDQI+++NG SL G+ +I+K K
Sbjct: 1994 GAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTK 2032
Score = 40.0 bits (92), Expect = 0.009
Identities = 47/181 (25%), Positives = 69/181 (38%), Gaps = 53/181 (29%)
Query: 682 TVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVR 741
+V I + G A K G+L I D+++ ING L G SIIK S+VK+ +R
Sbjct: 1374 SVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCA--PSKVKIIFIR 1431
Query: 742 ----------CP--------------------PVTTVLIRRPDL--------------RY 757
CP P T DL +
Sbjct: 1432 NKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQG 1491
Query: 758 QLGFSVQNG------IICSLMRGGIAERGG-VRVGHRIIEINGQSVVATPHEKIVHILSN 810
LG ++ II SL G+A G ++VG +I+ ++ + VV P EK + +L
Sbjct: 1492 GLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKT 1551
Query: 811 A 811
A
Sbjct: 1552 A 1552
Score = 37.7 bits (86), Expect = 0.045
Identities = 21/59 (35%), Positives = 32/59 (54%), Gaps = 2/59 (3%)
Query: 683 VIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVR 741
VI+ ++ GG A++ G+L GD I+ I T L G+ +++ N RVKL I R
Sbjct: 279 VIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGN--RVKLMIAR 335
Score = 36.2 bits (82), Expect = 0.13
Identities = 19/64 (29%), Positives = 36/64 (56%), Gaps = 1/64 (1%)
Query: 683 VIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVRC 742
+II +++ GG AEK G+L GD++M +N +L L +KG + V++ + +
Sbjct: 728 IIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPS-GTVRIGVAKP 786
Query: 743 PPVT 746
P++
Sbjct: 787 LPLS 790
Score = 34.7 bits (78), Expect = 0.38
Identities = 25/81 (30%), Positives = 41/81 (50%), Gaps = 12/81 (14%)
Query: 674 SGWGSILPTVI----IANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGL 729
SG G L + I +++ GP SGKL GD+++ +NG +L+G +I+K L
Sbjct: 563 SGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKEL 622
Query: 730 KNQSRVKLNIVRC----PPVT 746
+++ +V C PP T
Sbjct: 623 P----IEVTMVCCRRTVPPTT 639
Score = 34.7 bits (78), Expect = 0.38
Identities = 13/45 (28%), Positives = 30/45 (66%)
Query: 683 VIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIK 727
+I+ +++HGG + G++ IGD I+SIN S + + + +++++
Sbjct: 1031 MIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLR 1075
Score = 32.0 bits (71), Expect = 2.4
Identities = 15/55 (27%), Positives = 31/55 (56%), Gaps = 3/55 (5%)
Query: 683 VIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKL 737
+ + ++ E G++ IGDQI++++GT+L G T Q ++ L++ + L
Sbjct: 405 IFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGF---TNQQAVEVLRHTGQTVL 456
Score = 31.2 bits (69), Expect = 4.2
Identities = 25/92 (27%), Positives = 44/92 (47%), Gaps = 16/92 (17%)
Query: 630 EYSDLLNTQDMYNDDLIHFSKSENCKDVFIEKQKGEILGVVIVES-GWGS------ILPT 682
E S+L NT +S + V + ++ + LG+ IV G GS ++
Sbjct: 1134 EESELQNTA---------YSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRG 1184
Query: 683 VIIANMMHGGPAEKSGKLNIGDQIMSINGTSL 714
+ I +++ PA K+G L GD+I+ ++G L
Sbjct: 1185 IFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDL 1216
>gi|223890252 glutamate receptor interacting protein 1 [Homo
sapiens]
Length = 1076
Score = 55.5 bits (132), Expect = 2e-07
Identities = 52/223 (23%), Positives = 96/223 (43%), Gaps = 23/223 (10%)
Query: 619 NGINPEDLSQKEYSDLLNTQDMYNDDLIHFS--------KSENCKDVFIEKQKGEILGVV 670
NGI ED + +E S LL + + + S V + K+ LG+
Sbjct: 476 NGIPTEDSTFEEASQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKHNVELGIT 535
Query: 671 IVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLK 730
I ++I+++ G A ++G L +GD++++I+ L + I++ +
Sbjct: 536 ISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCE 595
Query: 731 NQSRVKL-----NIVRCPPVTTVLIRRPDLRY--QLGFSVQNG-------IICSLMRGGI 776
+ ++K+ N ++ RY LG ++ II SL +GG+
Sbjct: 596 DLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITISGTEEPFDPIIISSLTKGGL 655
Query: 777 AER-GGVRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMK 818
AER G + +G RI+ IN S+ P + +H+L A + +K
Sbjct: 656 AERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLK 698
Score = 49.7 bits (117), Expect = 1e-05
Identities = 36/163 (22%), Positives = 73/163 (44%), Gaps = 20/163 (12%)
Query: 683 VIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLN---- 738
V+I + GGPA++ G + GD+++S++G L+G + SI+K ++ + +
Sbjct: 180 VVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVS 239
Query: 739 -----IVRCPPVTTVLIRRPDLRYQLGFSVQNGIICS--------LMRGGIAER-GGVRV 784
P+ + + P LG ++ + C+ + IA+R G + V
Sbjct: 240 VMDSVATASGPLLVEVAKTPGA--SLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHV 297
Query: 785 GHRIIEINGQSVVATPHEKIVHILSNAVGEIHMKTMPAAMYRL 827
G I+ I+G S+ + L+N ++ ++ +P RL
Sbjct: 298 GDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRL 340
Score = 48.9 bits (115), Expect = 2e-05
Identities = 45/174 (25%), Positives = 84/174 (48%), Gaps = 26/174 (14%)
Query: 657 VFIEKQKGEILGVVIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVG 716
V + K++G LG+ + SG ++N+ GG A +S +L++GD I ++NG +L
Sbjct: 54 VELMKKEGTTLGLTV--SGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAK 111
Query: 717 LPLSTCQSIIKGLKNQSRVKLNI-VRCPPV----TTVLIRRPDLRYQ-----LGFSVQNG 766
S++K + RV L + PPV ++V+ R ++ GF ++ G
Sbjct: 112 FRHDEIISLLKNV--GERVVLEVEYELPPVSVQGSSVIFRTVEVTLHKEGNTFGFVIRGG 169
Query: 767 -----------IICSLMRGGIAER-GGVRVGHRIIEINGQSVVATPHEKIVHIL 808
+I + GG A+R G ++ G R++ ++G ++ T H + + IL
Sbjct: 170 AHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSIL 223
Score = 48.9 bits (115), Expect = 2e-05
Identities = 35/108 (32%), Positives = 60/108 (55%), Gaps = 5/108 (4%)
Query: 616 LRANGINPEDLSQ--KEYSDLLNTQDMYNDDLIHFSKSENCKDVFIE-KQKGEILGVVIV 672
+R + + ED Q ++ DL+ + ++D +S +E K+ G LG+ I
Sbjct: 577 IRLDNCSMEDAVQILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITI- 635
Query: 673 ESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLS 720
SG +II+++ GG AE++G ++IGD+I++IN +SL G PLS
Sbjct: 636 -SGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLS 682
Score = 37.4 bits (85), Expect = 0.058
Identities = 34/152 (22%), Positives = 64/152 (42%), Gaps = 17/152 (11%)
Query: 684 IIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNI---- 739
+I+ + PAE+ G L IGD++M+ING +++ S+V L I
Sbjct: 450 LISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLEIEFDV 509
Query: 740 --VRCPPVTTVLIRRPDL-RYQLGFSVQNG---------IICSLMRGGIAER-GGVRVGH 786
P T ++ P +LG ++ + +I + +G +A R G + +G
Sbjct: 510 AESVIPSSGTFHVKLPKKHNVELGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGD 569
Query: 787 RIIEINGQSVVATPHEKIVHILSNAVGEIHMK 818
+++ I+ + E V IL + +K
Sbjct: 570 KLLAIDNIRLDNCSMEDAVQILQQCEDLVKLK 601
Score = 32.3 bits (72), Expect = 1.9
Identities = 23/64 (35%), Positives = 35/64 (54%), Gaps = 9/64 (14%)
Query: 759 LGFSVQNGI-------ICSLMRGGIAERGG-VRVGHRIIEINGQSVVATPHEKIVHILSN 810
LG +V GI + +L +GGIA R + VG I +NG ++ H++I+ +L N
Sbjct: 64 LGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKN 123
Query: 811 AVGE 814
VGE
Sbjct: 124 -VGE 126
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 54.7 bits (130), Expect = 4e-07
Identities = 43/161 (26%), Positives = 77/161 (47%), Gaps = 18/161 (11%)
Query: 681 PTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIV 740
P + I ++ GG A + G+L + D I+ +N + + S +K + S V+L +
Sbjct: 74 PGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALK--EAGSIVRLYVR 131
Query: 741 RCPPV--TTVLIRRPDLRYQLGFSVQNGI------------ICSLMRGGIAERGG-VRVG 785
R P+ T V I+ LGFS+ G+ + ++ GG A++ G ++VG
Sbjct: 132 RRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVG 191
Query: 786 HRIIEINGQSVVATPHEKIVHILSNAVGEIHMKT-MPAAMY 825
R++ +N S+ HE+ V IL N +++K P +Y
Sbjct: 192 DRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIY 232
Score = 40.8 bits (94), Expect = 0.005
Identities = 18/46 (39%), Positives = 29/46 (63%)
Query: 683 VIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKG 728
+ ++ ++ GGPA+ SG+L GDQI+S+NG L G + +KG
Sbjct: 341 IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKG 386
Score = 36.2 bits (82), Expect = 0.13
Identities = 22/72 (30%), Positives = 39/72 (54%), Gaps = 5/72 (6%)
Query: 682 TVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVR 741
++ + ++ GG A+K G+L +GD+++ +N SL + T + + LKN S V V
Sbjct: 170 SIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEV---THEEAVAILKNTSEVVYLKVG 226
Query: 742 CPPVTTVLIRRP 753
P TT+ + P
Sbjct: 227 KP--TTIYMTDP 236
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 54.7 bits (130), Expect = 4e-07
Identities = 43/161 (26%), Positives = 77/161 (47%), Gaps = 18/161 (11%)
Query: 681 PTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIV 740
P + I ++ GG A + G+L + D I+ +N + + S +K + S V+L +
Sbjct: 230 PGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALK--EAGSIVRLYVR 287
Query: 741 RCPPV--TTVLIRRPDLRYQLGFSVQNGI------------ICSLMRGGIAERGG-VRVG 785
R P+ T V I+ LGFS+ G+ + ++ GG A++ G ++VG
Sbjct: 288 RRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVG 347
Query: 786 HRIIEINGQSVVATPHEKIVHILSNAVGEIHMKT-MPAAMY 825
R++ +N S+ HE+ V IL N +++K P +Y
Sbjct: 348 DRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIY 388
Score = 40.8 bits (94), Expect = 0.005
Identities = 18/46 (39%), Positives = 29/46 (63%)
Query: 683 VIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKG 728
+ ++ ++ GGPA+ SG+L GDQI+S+NG L G + +KG
Sbjct: 549 IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKG 594
Score = 36.2 bits (82), Expect = 0.13
Identities = 22/72 (30%), Positives = 39/72 (54%), Gaps = 5/72 (6%)
Query: 682 TVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVR 741
++ + ++ GG A+K G+L +GD+++ +N SL + T + + LKN S V V
Sbjct: 326 SIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEV---THEEAVAILKNTSEVVYLKVG 382
Query: 742 CPPVTTVLIRRP 753
P TT+ + P
Sbjct: 383 KP--TTIYMTDP 392
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 54.7 bits (130), Expect = 4e-07
Identities = 43/161 (26%), Positives = 77/161 (47%), Gaps = 18/161 (11%)
Query: 681 PTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIV 740
P + I ++ GG A + G+L + D I+ +N + + S +K + S V+L +
Sbjct: 125 PGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALK--EAGSIVRLYVR 182
Query: 741 RCPPV--TTVLIRRPDLRYQLGFSVQNGI------------ICSLMRGGIAERGG-VRVG 785
R P+ T V I+ LGFS+ G+ + ++ GG A++ G ++VG
Sbjct: 183 RRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVG 242
Query: 786 HRIIEINGQSVVATPHEKIVHILSNAVGEIHMKT-MPAAMY 825
R++ +N S+ HE+ V IL N +++K P +Y
Sbjct: 243 DRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIY 283
Score = 40.8 bits (94), Expect = 0.005
Identities = 18/46 (39%), Positives = 29/46 (63%)
Query: 683 VIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKG 728
+ ++ ++ GGPA+ SG+L GDQI+S+NG L G + +KG
Sbjct: 444 IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKG 489
Score = 36.2 bits (82), Expect = 0.13
Identities = 22/72 (30%), Positives = 39/72 (54%), Gaps = 5/72 (6%)
Query: 682 TVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVR 741
++ + ++ GG A+K G+L +GD+++ +N SL + T + + LKN S V V
Sbjct: 221 SIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEV---THEEAVAILKNTSEVVYLKVG 277
Query: 742 CPPVTTVLIRRP 753
P TT+ + P
Sbjct: 278 KP--TTIYMTDP 287
>gi|222446609 rai-like protein [Homo sapiens]
Length = 630
Score = 52.0 bits (123), Expect = 2e-06
Identities = 60/262 (22%), Positives = 112/262 (42%), Gaps = 47/262 (17%)
Query: 400 DSPSPGSSSPLGAESSSTSLHPSDPVEASTNKESRKSLASFPTYVEVPGPCDP------- 452
+S PGSS P E+S + + P + ++ A P +PGP +P
Sbjct: 121 ESRDPGSSGPSSPETSLSRSGTAPPPQQDL--VGHRATALTPDSCPLPGPGEPTLRSRQD 178
Query: 453 ----EDLID-GIIFAANYLGSTQLL-SDKTPSKNVRMMQAQEAVSRIKMAQKLAKS--RK 504
+ L+ G+ + Y+G ++L S ++ +R +EA+SR+ A A +K
Sbjct: 179 RHFLQHLLGMGMNYCVRYMGCVEVLQSMRSLDFGMRTQVTREAISRLCEAVPGANGAIKK 238
Query: 505 KAPE--------GESQPM---TEVDLFISTQRIKVLNADTQETMMDHPLRTISYIADIGN 553
+ P G+S + L IST + ++N D Q+ + +H +++IS+
Sbjct: 239 RKPPVKFLSTVLGKSNLQFSGMNIKLTISTCSLTLMNLDNQQIIANHHMQSISF------ 292
Query: 554 IVVLMARRRMPRSNSQENVEASHPSQDGKRQYKMICHVFESED--AQLIAQSIGQAFSVA 611
A P + A P + CH+ E + AQ + +IGQAF +
Sbjct: 293 -----ASGGDPDTTDYVAYVAKDPVN------QRACHILECHNGMAQDVISTIGQAFELR 341
Query: 612 YQEFLRANGINPEDLSQKEYSD 633
++++L+ +N S++ + D
Sbjct: 342 FKQYLKNPSLNTSCESEEVHID 363
>gi|122937249 glutamate receptor interacting protein 2 [Homo
sapiens]
Length = 1141
Score = 52.0 bits (123), Expect = 2e-06
Identities = 54/226 (23%), Positives = 98/226 (43%), Gaps = 24/226 (10%)
Query: 616 LRANGINPEDLSQKEYSDLLNTQDMYNDDLIHFS--------KSENCKDVFIEKQKGEIL 667
L NGI ED + +E + LL + + ++ S V + K++ L
Sbjct: 607 LSINGIATEDGTMEEANQLLRDAALAHKVVLEVEFDVAESVIPSSGTFHVKLPKKRSVEL 666
Query: 668 GVVIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIK 727
G+ I + P +II+++ G A ++G L GD++++I+ L P+ I++
Sbjct: 667 GITISSASRKRGEP-LIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILR 725
Query: 728 GLKNQSRVKL-----NIVRCPPVTTVLIRRPDLRY--QLGFSVQNG-------IICSLMR 773
++ ++K+ N V RY LG ++ +I L +
Sbjct: 726 QCEDLVKLKIRKDEDNSDELETTGAVSYTVELKRYGGPLGITISGTEEPFDPIVISGLTK 785
Query: 774 GGIAER-GGVRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMK 818
G+AER G + VG RI+ IN S+ P + +H+L A + +K
Sbjct: 786 RGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLK 831
Score = 43.1 bits (100), Expect = 0.001
Identities = 40/162 (24%), Positives = 73/162 (45%), Gaps = 23/162 (14%)
Query: 661 KQKGEILGVVIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLS 720
K++G LG+ I SG ++N+ GG A +S LNIGD I S+NG L L
Sbjct: 150 KKEGSTLGLTI--SGGTDKDGKPRVSNLRPGGLAARSDLLNIGDYIRSVNGIHLTRLRHD 207
Query: 721 TCQSIIKGLKNQSRVKLNIVRCPPV----TTVLIRRPDLRY-----QLGFSVQNG----- 766
+++K + + +++ PP ++ + D+ GF ++ G
Sbjct: 208 EIITLLKNVGERVVLEVEYELPPPAPENNPRIISKTVDVSLYKEGNSFGFVLRGGAHEDG 267
Query: 767 ------IICSLMRGGIAER-GGVRVGHRIIEINGQSVVATPH 801
++ + GG A+R G ++VG R++ ++G + H
Sbjct: 268 HKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASH 309
Score = 41.2 bits (95), Expect = 0.004
Identities = 34/172 (19%), Positives = 81/172 (47%), Gaps = 17/172 (9%)
Query: 683 VIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNI-VR 741
+++ + GGPA++ G L +GD+++S++G L G +T + ++ +++ ++ V
Sbjct: 273 LVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQCSHEALFQVEYDVA 332
Query: 742 CP--------PVTTVLIRRPDLRYQLGF---SVQNGIICSLMR---GGIAER-GGVRVGH 786
P P+ +++ P + S++N + ++ R + +R G + G
Sbjct: 333 TPDTVANASGPLMVEIVKTPGSALGISLTTTSLRNKSVITIDRIKPASVVDRSGALHPGD 392
Query: 787 RIIEINGQSVVATPHEKIVHILSNAVGEIHMKTMPAAM-YRLLTAQEQPVYI 837
I+ I+G S+ + +L++ ++ ++ +P R L Q Q V +
Sbjct: 393 HILSIDGTSMEHCSLLEATKLLASISEKVRLEILPVPQSQRPLRPQRQVVKV 444
Score = 39.7 bits (91), Expect = 0.012
Identities = 33/142 (23%), Positives = 62/142 (43%), Gaps = 16/142 (11%)
Query: 693 PAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNI------VRCPPVT 746
PAE+ G L +GD+++SING + + +++ +V L + P
Sbjct: 593 PAERCGLLQVGDRVLSINGIATEDGTMEEANQLLRDAALAHKVVLEVEFDVAESVIPSSG 652
Query: 747 TVLIRRPDLR-YQLGFSVQNG--------IICSLMRGGIAER-GGVRVGHRIIEINGQSV 796
T ++ P R +LG ++ + II + +G +A R G + G +++ I+ +
Sbjct: 653 TFHVKLPKKRSVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRL 712
Query: 797 VATPHEKIVHILSNAVGEIHMK 818
P E V IL + +K
Sbjct: 713 DNCPMEDAVQILRQCEDLVKLK 734
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 51.6 bits (122), Expect = 3e-06
Identities = 38/169 (22%), Positives = 71/169 (42%), Gaps = 13/169 (7%)
Query: 681 PTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIV 740
P + I ++ GG A G+L + D ++ +N + + S +K R+ +
Sbjct: 158 PGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRR 217
Query: 741 RCPPVTTVLIRRPDLRYQLGFSVQNGI------------ICSLMRGGIAERGG-VRVGHR 787
+ PP T + + LGFS+ GI I ++ GG A++ G +++G R
Sbjct: 218 QPPPETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDR 277
Query: 788 IIEINGQSVVATPHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVY 836
++ +N ++ HE+ V L N +++K L P Y
Sbjct: 278 LLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDY 326
Score = 36.6 bits (83), Expect = 0.099
Identities = 14/32 (43%), Positives = 25/32 (78%)
Query: 683 VIIANMMHGGPAEKSGKLNIGDQIMSINGTSL 714
+ ++ ++ GGPA+ SG+L GD+I+S+NG +L
Sbjct: 409 IFVSFILAGGPADLSGELRRGDRILSVNGVNL 440
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 51.2 bits (121), Expect = 4e-06
Identities = 40/156 (25%), Positives = 73/156 (46%), Gaps = 23/156 (14%)
Query: 681 PTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIV 740
P++ I ++ GG A + G+L + D I+ +N + + S +K + S V+L ++
Sbjct: 135 PSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALK--EAGSIVRLYVM 192
Query: 741 -RCPPVTTV----LIRRPDLRYQLGFSVQNGI------------ICSLMRGGIAERGG-V 782
R PP V LI+ P LGFS+ G+ + ++ GG A + G +
Sbjct: 193 RRKPPAEKVMEIKLIKGPK---GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRL 249
Query: 783 RVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMK 818
++G +I+ +N + HE V L N +++K
Sbjct: 250 QIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLK 285
Score = 38.1 bits (87), Expect = 0.034
Identities = 16/32 (50%), Positives = 24/32 (75%)
Query: 683 VIIANMMHGGPAEKSGKLNIGDQIMSINGTSL 714
+ I+ ++ GGPA+ SG+L GDQI+S+NG L
Sbjct: 379 IFISFILAGGPADLSGELRKGDQILSVNGVDL 410
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 51.2 bits (121), Expect = 4e-06
Identities = 40/156 (25%), Positives = 73/156 (46%), Gaps = 23/156 (14%)
Query: 681 PTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIV 740
P++ I ++ GG A + G+L + D I+ +N + + S +K + S V+L ++
Sbjct: 89 PSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALK--EAGSIVRLYVM 146
Query: 741 -RCPPVTTV----LIRRPDLRYQLGFSVQNGI------------ICSLMRGGIAERGG-V 782
R PP V LI+ P LGFS+ G+ + ++ GG A + G +
Sbjct: 147 RRKPPAEKVMEIKLIKGPK---GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRL 203
Query: 783 RVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMK 818
++G +I+ +N + HE V L N +++K
Sbjct: 204 QIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLK 239
Score = 38.1 bits (87), Expect = 0.034
Identities = 16/32 (50%), Positives = 24/32 (75%)
Query: 683 VIIANMMHGGPAEKSGKLNIGDQIMSINGTSL 714
+ I+ ++ GGPA+ SG+L GDQI+S+NG L
Sbjct: 333 IFISFILAGGPADLSGELRKGDQILSVNGVDL 364
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 50.1 bits (118), Expect = 9e-06
Identities = 37/160 (23%), Positives = 76/160 (47%), Gaps = 18/160 (11%)
Query: 682 TVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVR 741
++ I ++ GG A + G+L + D I+ +N + + S +K + S V+L + R
Sbjct: 252 SIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALK--EAGSIVRLYVKR 309
Query: 742 CPPVTTVLIRRPDLR--YQLGFSVQNGI------------ICSLMRGGIAERGG-VRVGH 786
PV+ ++ ++ LGFS+ G+ + ++ GG A + G +++G
Sbjct: 310 RKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGD 369
Query: 787 RIIEINGQSVVATPHEKIVHILSNAVGEIHMK-TMPAAMY 825
+++ +N + HE+ V L N +++K P +MY
Sbjct: 370 KLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMY 409
Score = 37.4 bits (85), Expect = 0.058
Identities = 42/189 (22%), Positives = 68/189 (35%), Gaps = 59/189 (31%)
Query: 682 TVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVK----- 736
++ + ++ GG A K GKL IGD+++++N L + + +K + +K
Sbjct: 347 SIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPT 406
Query: 737 ---LNIVRCPPVTTVLIRRP-----------------DLRYQ------------------ 758
+N PP T +P RY
Sbjct: 407 SMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRK 466
Query: 759 ---------LGFSVQNG------IICSLMRGGIAERGG-VRVGHRIIEINGQSVVATPHE 802
LGF++ G I ++ GG A+ G +R G RII +N + A HE
Sbjct: 467 VVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHE 526
Query: 803 KIVHILSNA 811
+ L NA
Sbjct: 527 QAAAALKNA 535
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 50.1 bits (118), Expect = 9e-06
Identities = 37/160 (23%), Positives = 76/160 (47%), Gaps = 18/160 (11%)
Query: 682 TVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVR 741
++ I ++ GG A + G+L + D I+ +N + + S +K + S V+L + R
Sbjct: 252 SIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALK--EAGSIVRLYVKR 309
Query: 742 CPPVTTVLIRRPDLR--YQLGFSVQNGI------------ICSLMRGGIAERGG-VRVGH 786
PV+ ++ ++ LGFS+ G+ + ++ GG A + G +++G
Sbjct: 310 RKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGD 369
Query: 787 RIIEINGQSVVATPHEKIVHILSNAVGEIHMK-TMPAAMY 825
+++ +N + HE+ V L N +++K P +MY
Sbjct: 370 KLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMY 409
Score = 37.4 bits (85), Expect = 0.058
Identities = 42/189 (22%), Positives = 68/189 (35%), Gaps = 59/189 (31%)
Query: 682 TVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVK----- 736
++ + ++ GG A K GKL IGD+++++N L + + +K + +K
Sbjct: 347 SIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPT 406
Query: 737 ---LNIVRCPPVTTVLIRRP-----------------DLRYQ------------------ 758
+N PP T +P RY
Sbjct: 407 SMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRK 466
Query: 759 ---------LGFSVQNG------IICSLMRGGIAERGG-VRVGHRIIEINGQSVVATPHE 802
LGF++ G I ++ GG A+ G +R G RII +N + A HE
Sbjct: 467 VVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHE 526
Query: 803 KIVHILSNA 811
+ L NA
Sbjct: 527 QAAAALKNA 535
>gi|10835173 nitric oxide synthase 1, neuronal [Homo sapiens]
Length = 1434
Score = 49.3 bits (116), Expect = 1e-05
Identities = 24/63 (38%), Positives = 42/63 (66%), Gaps = 1/63 (1%)
Query: 681 PTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIV 740
P VII++++ GG AE+SG + GD I+++NG LV L + +++G+ +++ V L I+
Sbjct: 39 PPVIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHVVL-IL 97
Query: 741 RCP 743
R P
Sbjct: 98 RGP 100
Score = 35.8 bits (81), Expect = 0.17
Identities = 17/52 (32%), Positives = 30/52 (57%), Gaps = 1/52 (1%)
Query: 767 IICSLMRGGIAERGG-VRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHM 817
II L+RGG AE+ G ++ G I+ +NG+ +V ++ + +L E H+
Sbjct: 42 IISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHV 93
>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
containing 2 [Homo sapiens]
Length = 1455
Score = 48.1 bits (113), Expect = 3e-05
Identities = 28/85 (32%), Positives = 47/85 (55%), Gaps = 7/85 (8%)
Query: 649 SKSENCKDVFIEKQKGEILGVVIV------ESGWGSILPTVIIANMMHGGPAEKSGKLNI 702
S S DV I +++ E G VI+ ESG +P I ++ G PA++ KL +
Sbjct: 913 SHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKI-GRIIDGSPADRCAKLKV 971
Query: 703 GDQIMSINGTSLVGLPLSTCQSIIK 727
GD+I+++NG S++ +P + +IK
Sbjct: 972 GDRILAVNGQSIINMPHADIVKLIK 996
Score = 37.0 bits (84), Expect = 0.076
Identities = 17/52 (32%), Positives = 33/52 (63%), Gaps = 1/52 (1%)
Query: 771 LMRGGIAER-GGVRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMKTMP 821
++ G A+R ++VG RI+ +NGQS++ PH IV ++ +A + ++ +P
Sbjct: 957 IIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIP 1008
Score = 33.5 bits (75), Expect = 0.84
Identities = 16/53 (30%), Positives = 29/53 (54%)
Query: 685 IANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKL 737
+ + GPA ++G++ +GDQI+ ING S + + +IK + R+ L
Sbjct: 1173 VLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGRRVRLLL 1225
Score = 32.7 bits (73), Expect = 1.4
Identities = 20/59 (33%), Positives = 31/59 (52%), Gaps = 8/59 (13%)
Query: 760 GFSVQNG-------IICSLMRGGIAERGG-VRVGHRIIEINGQSVVATPHEKIVHILSN 810
GFS++ G + L G A R G +RVG +IIEING+S H + + ++ +
Sbjct: 1158 GFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKS 1216
>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform c [Homo sapiens]
Length = 1462
Score = 47.8 bits (112), Expect = 4e-05
Identities = 51/223 (22%), Positives = 84/223 (37%), Gaps = 68/223 (30%)
Query: 656 DVFIEKQKGEILGVVIVES----------GWGSILPTVIIANMMHGGPAEKSGKLNIGDQ 705
DV I + + E G VIV S G + I ++ G PA++ GKL +GD+
Sbjct: 970 DVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDR 1029
Query: 706 IMSINGTSLVGLPLSTCQSIIKGLKNQSRVKL-------------NIVRCPPVTTV---- 748
I+++NG S+ S ++IK N +++ N + +TT
Sbjct: 1030 ILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPS 1089
Query: 749 --------LIRRPDLRYQ-------------------------LGFSVQNG-------II 768
+P Q GFS++ G +
Sbjct: 1090 QQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYV 1149
Query: 769 CSLMRGGIAER-GGVRVGHRIIEINGQSVVATPHEKIVHILSN 810
L G AER G +R+G I+EING++ H + + ++ N
Sbjct: 1150 LRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKN 1192
Score = 37.4 bits (85), Expect = 0.058
Identities = 20/57 (35%), Positives = 31/57 (54%), Gaps = 2/57 (3%)
Query: 685 IANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVR 741
+ + GPAE+ GK+ IGD+I+ ING + + S +IK RV+L + R
Sbjct: 1149 VLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIK--NGGRRVRLFLKR 1203
Score = 34.7 bits (78), Expect = 0.38
Identities = 16/52 (30%), Positives = 31/52 (59%), Gaps = 1/52 (1%)
Query: 771 LMRGGIAER-GGVRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMKTMP 821
++ G A+R G ++VG RI+ +NG S+ H IV+++ A + ++ +P
Sbjct: 1012 IIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIP 1063
Score = 33.1 bits (74), Expect = 1.1
Identities = 18/61 (29%), Positives = 32/61 (52%)
Query: 685 IANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVRCPP 744
I +++ GPA GK+ GD I+S+N T ++G + I + + + V L + R P
Sbjct: 498 IKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYP 557
Query: 745 V 745
+
Sbjct: 558 L 558
Score = 32.0 bits (71), Expect = 2.4
Identities = 14/59 (23%), Positives = 31/59 (52%)
Query: 683 VIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVR 741
+ I +++ G A+ G+L GD+++ ++GT ++G +++ Q V L + R
Sbjct: 837 IYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRR 895
>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform a [Homo sapiens]
Length = 1287
Score = 47.8 bits (112), Expect = 4e-05
Identities = 51/223 (22%), Positives = 84/223 (37%), Gaps = 68/223 (30%)
Query: 656 DVFIEKQKGEILGVVIVES----------GWGSILPTVIIANMMHGGPAEKSGKLNIGDQ 705
DV I + + E G VIV S G + I ++ G PA++ GKL +GD+
Sbjct: 998 DVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDR 1057
Query: 706 IMSINGTSLVGLPLSTCQSIIKGLKNQSRVKL-------------NIVRCPPVTTV---- 748
I+++NG S+ S ++IK N +++ N + +TT
Sbjct: 1058 ILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPS 1117
Query: 749 --------LIRRPDLRYQ-------------------------LGFSVQNG-------II 768
+P Q GFS++ G +
Sbjct: 1118 QQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYV 1177
Query: 769 CSLMRGGIAER-GGVRVGHRIIEINGQSVVATPHEKIVHILSN 810
L G AER G +R+G I+EING++ H + + ++ N
Sbjct: 1178 LRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKN 1220
Score = 37.4 bits (85), Expect = 0.058
Identities = 20/57 (35%), Positives = 31/57 (54%), Gaps = 2/57 (3%)
Query: 685 IANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVR 741
+ + GPAE+ GK+ IGD+I+ ING + + S +IK RV+L + R
Sbjct: 1177 VLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIK--NGGRRVRLFLKR 1231
Score = 34.7 bits (78), Expect = 0.38
Identities = 16/52 (30%), Positives = 31/52 (59%), Gaps = 1/52 (1%)
Query: 771 LMRGGIAER-GGVRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMKTMP 821
++ G A+R G ++VG RI+ +NG S+ H IV+++ A + ++ +P
Sbjct: 1040 IIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIP 1091
Score = 33.1 bits (74), Expect = 1.1
Identities = 18/61 (29%), Positives = 32/61 (52%)
Query: 685 IANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVRCPP 744
I +++ GPA GK+ GD I+S+N T ++G + I + + + V L + R P
Sbjct: 498 IKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYP 557
Query: 745 V 745
+
Sbjct: 558 L 558
Score = 32.0 bits (71), Expect = 2.4
Identities = 14/59 (23%), Positives = 31/59 (52%)
Query: 683 VIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVR 741
+ I +++ G A+ G+L GD+++ ++GT ++G +++ Q V L + R
Sbjct: 865 IYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRR 923
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.130 0.367
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,840,359
Number of Sequences: 37866
Number of extensions: 1694295
Number of successful extensions: 10549
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 167
Number of HSP's successfully gapped in prelim test: 305
Number of HSP's that attempted gapping in prelim test: 9015
Number of HSP's gapped (non-prelim): 1788
length of query: 837
length of database: 18,247,518
effective HSP length: 111
effective length of query: 726
effective length of database: 14,044,392
effective search space: 10196228592
effective search space used: 10196228592
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.