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Search of human proteins with 22027482
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22027482 neuronal PAS domain protein 1 [Homo sapiens]
(590 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22027482 neuronal PAS domain protein 1 [Homo sapiens] 1201 0.0
gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens] 468 e-132
gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens] 461 e-130
gi|21614542 single-minded homolog 1 [Homo sapiens] 276 4e-74
gi|4827004 single-minded homolog 2 long isoform [Homo sapiens] 274 2e-73
gi|194239684 single-minded homolog 2 short isoform [Homo sapiens] 274 2e-73
gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2 ... 212 7e-55
gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1 [... 212 7e-55
gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a ... 205 8e-53
gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c ... 205 8e-53
gi|40254439 endothelial PAS domain protein 1 [Homo sapiens] 200 3e-51
gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b ... 162 8e-40
gi|4502003 aryl hydrocarbon receptor [Homo sapiens] 115 1e-25
gi|31745180 aryl hydrocarbon receptor nuclear translocator-like ... 105 1e-22
gi|71852582 aryl hydrocarbon receptor nuclear translocator-like ... 99 8e-21
gi|71852580 aryl hydrocarbon receptor nuclear translocator-like ... 99 8e-21
gi|42716311 aryl hydrocarbon receptor nuclear translocator-like ... 99 8e-21
gi|115430245 arylhydrocarbon receptor repressor [Homo sapiens] 92 2e-18
gi|194097477 neuronal PAS domain protein 4 [Homo sapiens] 92 2e-18
gi|4758010 clock [Homo sapiens] 80 4e-15
gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Ho... 77 4e-14
gi|30795242 aryl hydrocarbon receptor nuclear translocator isofo... 74 3e-13
gi|4502231 aryl hydrocarbon receptor nuclear translocator isofor... 74 3e-13
gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens] 69 2e-11
gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens] 69 2e-11
gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens] 69 2e-11
gi|30795240 aryl hydrocarbon receptor nuclear translocator isofo... 65 2e-10
gi|5729858 nuclear receptor coactivator 2 [Homo sapiens] 59 1e-08
gi|22027471 neuronal PAS domain protein 2 [Homo sapiens] 59 1e-08
gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens] 55 2e-07
>gi|22027482 neuronal PAS domain protein 1 [Homo sapiens]
Length = 590
Score = 1201 bits (3107), Expect = 0.0
Identities = 590/590 (100%), Positives = 590/590 (100%)
Query: 1 MAAPYPGSGGGSEVKCVGGRGASVPWDFLPGLMVKAPSGPCLQAQRKEKSRNAARSRRGK 60
MAAPYPGSGGGSEVKCVGGRGASVPWDFLPGLMVKAPSGPCLQAQRKEKSRNAARSRRGK
Sbjct: 1 MAAPYPGSGGGSEVKCVGGRGASVPWDFLPGLMVKAPSGPCLQAQRKEKSRNAARSRRGK 60
Query: 61 ENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGLRAAGPPAGLA 120
ENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGLRAAGPPAGLA
Sbjct: 61 ENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGLRAAGPPAGLA 120
Query: 121 PGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVEMTGS 180
PGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVEMTGS
Sbjct: 121 PGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVEMTGS 180
Query: 181 SVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLADTPEIEASLTKVPPSS 240
SVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLADTPEIEASLTKVPPSS
Sbjct: 181 SVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLADTPEIEASLTKVPPSS 240
Query: 241 LVQERSFFVRMKSTLTKRGLHVKASGYKVIHVTGRLRAHALGLVALGHTLPPAPLAELPL 300
LVQERSFFVRMKSTLTKRGLHVKASGYKVIHVTGRLRAHALGLVALGHTLPPAPLAELPL
Sbjct: 241 LVQERSFFVRMKSTLTKRGLHVKASGYKVIHVTGRLRAHALGLVALGHTLPPAPLAELPL 300
Query: 301 HGHMIVFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDLLDK 360
HGHMIVFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDLLDK
Sbjct: 301 HGHMIVFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDLLDK 360
Query: 361 GQVMTGYYRWLQRAGGFVWLQSVATVAGSGKSPGEHHVLWVSHVLSQAEGGQTPLDAFQL 420
GQVMTGYYRWLQRAGGFVWLQSVATVAGSGKSPGEHHVLWVSHVLSQAEGGQTPLDAFQL
Sbjct: 361 GQVMTGYYRWLQRAGGFVWLQSVATVAGSGKSPGEHHVLWVSHVLSQAEGGQTPLDAFQL 420
Query: 421 PASVACEEASSPGPEPTEPEPPTEGKQAAPAENEAPQTQGKRIKVEPGPRETKGSEDSGD 480
PASVACEEASSPGPEPTEPEPPTEGKQAAPAENEAPQTQGKRIKVEPGPRETKGSEDSGD
Sbjct: 421 PASVACEEASSPGPEPTEPEPPTEGKQAAPAENEAPQTQGKRIKVEPGPRETKGSEDSGD 480
Query: 481 EDPSSHPATPRPEFTSVIRAGVLKQDPVRPWGLAPPGDPPPTLLHAGFLPPVVRGLCTPG 540
EDPSSHPATPRPEFTSVIRAGVLKQDPVRPWGLAPPGDPPPTLLHAGFLPPVVRGLCTPG
Sbjct: 481 EDPSSHPATPRPEFTSVIRAGVLKQDPVRPWGLAPPGDPPPTLLHAGFLPPVVRGLCTPG 540
Query: 541 TIRYGPAELGLVYPHLQRLGPGPALPEAFYPPLGLPYPGPAGTRLPRKGD 590
TIRYGPAELGLVYPHLQRLGPGPALPEAFYPPLGLPYPGPAGTRLPRKGD
Sbjct: 541 TIRYGPAELGLVYPHLQRLGPGPALPEAFYPPLGLPYPGPAGTRLPRKGD 590
>gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens]
Length = 901
Score = 468 bits (1205), Expect = e-132
Identities = 244/463 (52%), Positives = 319/463 (68%), Gaps = 37/463 (7%)
Query: 42 LQAQRKEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFA 101
LQA RKEKSR+AARSRRGKEN EF+ELAKLLPLP AI+SQLDKASI+RL+++YL++R FA
Sbjct: 18 LQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFA 77
Query: 102 ALGAPPWGLRAAGPPAGL----APGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEG 157
G PPW LR GPP A RR P+AL EVFE HLG HILQSLDGFVFALNQEG
Sbjct: 78 NQGDPPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEG 137
Query: 158 KFLYISETVSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPG----PPTPPSV 213
KFLYISETVSIYLGLSQVE+TGSSVFDY+HPGDH E+ EQLG++ P PG
Sbjct: 138 KFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLP-PGRGLLSQGTAED 196
Query: 214 SSSSSSSSSLADTPE-IEASLTKVPPSSLVQERSFFVRMKSTLTKRGLHVKASGYKVIHV 272
+SS+SSSS ++TPE +E++ + + ERSFF+RMKSTLTKRG+H+K+SGYKVIH+
Sbjct: 197 GASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRGVHIKSSGYKVIHI 256
Query: 273 TGRLR------------AHALGLVALGHTLPPAPLAELPLHGHMIVFRLSLGLTILACES 320
TGRLR + +GLV + H LPP + E+ + HM V R+++ L I+ CE+
Sbjct: 257 TGRLRLRVSLSHGRTVPSQIMGLVVVAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCEN 316
Query: 321 RVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDLLDKGQVMTGYYRWLQRAGGFVWL 380
R+SD+MDL P ++VG+ CY F+H +D IR SH+DLL+KGQ +T YYRW+Q+ GG++W+
Sbjct: 317 RISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGYIWI 376
Query: 381 QSVATVAGSGKSPGEHHVLWVSHVLSQAEGGQTPLDAFQLPASVACEEASSPGPEPTEPE 440
QS AT+A + K+ E +++WV+++LS E TP+D QLP PE
Sbjct: 377 QSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHL---------------PE 421
Query: 441 PPTEGKQAAPAENEAPQTQGKRIKVEPGPRETKGSEDSGDEDP 483
+E + + +E+++ T G E + KG++ EDP
Sbjct: 422 KTSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDP 464
>gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens]
Length = 920
Score = 461 bits (1186), Expect = e-130
Identities = 244/482 (50%), Positives = 319/482 (66%), Gaps = 56/482 (11%)
Query: 42 LQAQRKEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFA 101
LQA RKEKSR+AARSRRGKEN EF+ELAKLLPLP AI+SQLDKASI+RL+++YL++R FA
Sbjct: 18 LQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFA 77
Query: 102 ALGAPPWGLRAAGPPAGL-----------------------APGRRGPAALVSEVFEQHL 138
G PPW LR GPP A RR P+AL EVFE HL
Sbjct: 78 NQGDPPWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHL 137
Query: 139 GGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQL 198
G HILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVE+TGSSVFDY+HPGDH E+ EQL
Sbjct: 138 GSHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQL 197
Query: 199 GLRTPTPG----PPTPPSVSSSSSSSSSLADTPE-IEASLTKVPPSSLVQERSFFVRMKS 253
G++ P PG +SS+SSSS ++TPE +E++ + + ERSFF+RMKS
Sbjct: 198 GMKLP-PGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKS 256
Query: 254 TLTKRGLHVKASGYKVIHVTGRLR------------AHALGLVALGHTLPPAPLAELPLH 301
TLTKRG+H+K+SGYKVIH+TGRLR + +GLV + H LPP + E+ +
Sbjct: 257 TLTKRGVHIKSSGYKVIHITGRLRLRVSLSHGRTVPSQIMGLVVVAHALPPPTINEVRID 316
Query: 302 GHMIVFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDLLDKG 361
HM V R+++ L I+ CE+R+SD+MDL P ++VG+ CY F+H +D IR SH+DLL+KG
Sbjct: 317 CHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKG 376
Query: 362 QVMTGYYRWLQRAGGFVWLQSVATVAGSGKSPGEHHVLWVSHVLSQAEGGQTPLDAFQLP 421
Q +T YYRW+Q+ GG++W+QS AT+A + K+ E +++WV+++LS E TP+D QLP
Sbjct: 377 QCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLP 436
Query: 422 ASVACEEASSPGPEPTEPEPPTEGKQAAPAENEAPQTQGKRIKVEPGPRETKGSEDSGDE 481
PE +E + + +E+++ T G E + KG++ E
Sbjct: 437 HL---------------PEKTSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSE 481
Query: 482 DP 483
DP
Sbjct: 482 DP 483
>gi|21614542 single-minded homolog 1 [Homo sapiens]
Length = 766
Score = 276 bits (706), Expect = 4e-74
Identities = 177/464 (38%), Positives = 248/464 (53%), Gaps = 74/464 (15%)
Query: 47 KEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALG-A 105
KEKS+NAAR+RR KEN EF+ELAKLLPLP AI+SQLDKASI+RL+ +YL++R G
Sbjct: 2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLG 61
Query: 106 PPWGLRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISET 165
WG + P + + LG H+LQ+LDGF+F + +GK +YISET
Sbjct: 62 EAWGHSSRTSPL--------------DNVGRELGSHLLQTLDGFIFVVAPDGKIMYISET 107
Query: 166 VSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLAD 225
S++LGLSQVE+TG+S+++YIHP DH E+ L P S
Sbjct: 108 ASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLTAHQP---------------YHSHFVQ 152
Query: 226 TPEIEASLTKVPPSSLVQERSFFVRMKSTLTKRGLHVKASGYKVIHVTG--RLRAHAL-- 281
EI ERSFF+RMK L KR + GYKVIH +G ++R ++L
Sbjct: 153 EYEI--------------ERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLKIRQYSLDM 198
Query: 282 ----------GLVALGHTLPPAPLAELPLHGHMIVFRLSLGLTILACESRVSDHMDLGPS 331
GLVA+GH+LPP+ + E+ LH +M +FR SL + ++ +SRV++ P
Sbjct: 199 SPFDGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQ 258
Query: 332 ELVGRSCYQFVHGQDATRIRQSHVDLLDKGQVMTGYYRWLQRAGGFVWLQSVATVAGSGK 391
+L+ ++ Y VHG D +R +H LL KGQV T YYR+L + GG+VW+QS AT+ + +
Sbjct: 259 DLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSR 318
Query: 392 SPGEHHVLWVSHVLSQAE--GGQTPLDAFQLPASVACEEASSPGPEPTEPEPPTEGKQAA 449
S H ++ V++VL+ E G Q LD AS P T PT
Sbjct: 319 SSRPHCIVSVNYVLTDTEYKGLQLSLDQI---------SASKPAFSYTSSSTPTMTDNRK 369
Query: 450 PAENEAPQTQGKRIKVEPGPR----ETKGSEDSGDEDPSSHPAT 489
A++ ++ K + P P+ T+ SE D P T
Sbjct: 370 GAKSRLSSSKSKS-RTSPYPQYSGFHTERSESDHDSQWGGSPLT 412
>gi|4827004 single-minded homolog 2 long isoform [Homo sapiens]
Length = 667
Score = 274 bits (700), Expect = 2e-73
Identities = 163/389 (41%), Positives = 225/389 (57%), Gaps = 58/389 (14%)
Query: 47 KEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALG-A 105
KEKS+NAA++RR KEN EF+ELAKLLPLP AI+SQLDKASI+RL+ +YL++R G
Sbjct: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61
Query: 106 PPWGLRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISET 165
WG P R GP V++ LG H+LQ+LDGFVF + +GK +YISET
Sbjct: 62 DAWG----------QPSRAGPLDGVAK----ELGSHLLQTLDGFVFVVASDGKIMYISET 107
Query: 166 VSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLAD 225
S++LGLSQVE+TG+S+++YIHP DH E+ L P L
Sbjct: 108 ASVHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHQPL---------------HHHLLQ 152
Query: 226 TPEIEASLTKVPPSSLVQERSFFVRMKSTLTKRGLHVKASGYKVIHVTGRLRA------- 278
EI ERSFF+RMK L KR + SGYKVIH +G L+
Sbjct: 153 EYEI--------------ERSFFLRMKCVLAKRNAGLTCSGYKVIHCSGYLKIRQYMLDM 198
Query: 279 -------HALGLVALGHTLPPAPLAELPLHGHMIVFRLSLGLTILACESRVSDHMDLGPS 331
+GLVA+G +LPP+ + E+ L+ +M +FR SL L ++ +SRV++ P
Sbjct: 199 SLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEVTGYEPQ 258
Query: 332 ELVGRSCYQFVHGQDATRIRQSHVDLLDKGQVMTGYYRWLQRAGGFVWLQSVATVAGSGK 391
+L+ ++ Y VHG D +R +H LL KGQV T YYR L + GG+VW+QS ATV + +
Sbjct: 259 DLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSR 318
Query: 392 SPGEHHVLWVSHVLSQAEGGQTPLDAFQL 420
S H ++ V++VL++ E + L Q+
Sbjct: 319 SSRPHCIVSVNYVLTEIEYKELQLSLEQV 347
Score = 31.2 bits (69), Expect = 2.8
Identities = 57/220 (25%), Positives = 76/220 (34%), Gaps = 38/220 (17%)
Query: 390 GKSPGEHHVLWVSHVLSQAEGGQ---TPLDAFQ-----LPASVACE---------EASSP 432
G P + HV + A+ GQ +P + + LPAS C+ +SSP
Sbjct: 445 GHFPLDSHVFSSKKPMLPAKFGQPQGSPCEVARFFLSTLPASGECQWHYANPLVPSSSSP 504
Query: 433 GPEPTEPEPPTEGKQAAPAENEAPQTQGKRIKVEPGPRETKGSEDSGDEDPSSHPATPRP 492
P EP T P+ EAP +R + P S E+P+ PA
Sbjct: 505 AKNPPEPPANTARHSLVPSY-EAPAAAVRRFGEDTAPPSFP-SCGHYREEPALGPAKAAR 562
Query: 493 EFT------SVIRAGVLKQDPVRPWGLAPPGDPPPTLLHAGFLPPVVRGLCTPGTIRYGP 546
+ ++ RA P P P P LL+ + R GP
Sbjct: 563 QAARDGARLALARAAPECCAPPTPEAPGAPAQLPFVLLNYHRV-----------LARRGP 611
Query: 547 AELGLVYPHLQRLGPGPALPEAFYPPLGLPYPGPAGTRLP 586
LG P L P PEA L L +P PA T P
Sbjct: 612 --LGGAAPAASGLACAPGGPEAATGALRLRHPSPAATSPP 649
>gi|194239684 single-minded homolog 2 short isoform [Homo sapiens]
Length = 570
Score = 274 bits (700), Expect = 2e-73
Identities = 163/389 (41%), Positives = 225/389 (57%), Gaps = 58/389 (14%)
Query: 47 KEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALG-A 105
KEKS+NAA++RR KEN EF+ELAKLLPLP AI+SQLDKASI+RL+ +YL++R G
Sbjct: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61
Query: 106 PPWGLRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISET 165
WG P R GP V++ LG H+LQ+LDGFVF + +GK +YISET
Sbjct: 62 DAWG----------QPSRAGPLDGVAK----ELGSHLLQTLDGFVFVVASDGKIMYISET 107
Query: 166 VSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLAD 225
S++LGLSQVE+TG+S+++YIHP DH E+ L P L
Sbjct: 108 ASVHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHQPL---------------HHHLLQ 152
Query: 226 TPEIEASLTKVPPSSLVQERSFFVRMKSTLTKRGLHVKASGYKVIHVTGRLRA------- 278
EI ERSFF+RMK L KR + SGYKVIH +G L+
Sbjct: 153 EYEI--------------ERSFFLRMKCVLAKRNAGLTCSGYKVIHCSGYLKIRQYMLDM 198
Query: 279 -------HALGLVALGHTLPPAPLAELPLHGHMIVFRLSLGLTILACESRVSDHMDLGPS 331
+GLVA+G +LPP+ + E+ L+ +M +FR SL L ++ +SRV++ P
Sbjct: 199 SLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEVTGYEPQ 258
Query: 332 ELVGRSCYQFVHGQDATRIRQSHVDLLDKGQVMTGYYRWLQRAGGFVWLQSVATVAGSGK 391
+L+ ++ Y VHG D +R +H LL KGQV T YYR L + GG+VW+QS ATV + +
Sbjct: 259 DLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSR 318
Query: 392 SPGEHHVLWVSHVLSQAEGGQTPLDAFQL 420
S H ++ V++VL++ E + L Q+
Sbjct: 319 SSRPHCIVSVNYVLTEIEYKELQLSLEQV 347
>gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2
[Homo sapiens]
Length = 735
Score = 212 bits (540), Expect = 7e-55
Identities = 131/379 (34%), Positives = 197/379 (51%), Gaps = 69/379 (18%)
Query: 45 QRKEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALG 104
+RKEKSR+AARSRR KE+ F+ELA LPLP +SS LDKAS++RL+++YLR+R+ G
Sbjct: 17 RRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAG 76
Query: 105 APPWGLRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISE 164
+ + + + L++LDGFV L +G +YIS+
Sbjct: 77 DLD----------------------IEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISD 114
Query: 165 TVSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLA 224
V+ Y+GL+Q E+TG SVFD+ HP DH E+ E L R
Sbjct: 115 NVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRN---------------------- 152
Query: 225 DTPEIEASLTKVPPSSLVQERSFFVRMKSTLTKRG--LHVKASGYKVIHVTGRLRAHALG 282
L K Q RSFF+RMK TLT RG +++K++ +KV+H TG + +
Sbjct: 153 -------GLVKKGKEQNTQ-RSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTN 204
Query: 283 ---------------LVALGHTLPPAPLAELPLHGHMIVFRLSLGLTILACESRVSDHMD 327
LV + +P E+PL + R SL + C+ R+++ M
Sbjct: 205 SNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMG 264
Query: 328 LGPSELVGRSCYQFVHGQDATRIRQSHVDLLDKGQVMTGYYRWLQRAGGFVWLQSVATVA 387
P EL+GRS Y++ H D+ + ++H D+ KGQV TG YR L + GG+VW+++ ATV
Sbjct: 265 YEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVI 324
Query: 388 GSGKSPGEHHVLWVSHVLS 406
+ K+ ++ V++V+S
Sbjct: 325 YNTKNSQPQCIVCVNYVVS 343
>gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1
[Homo sapiens]
Length = 826
Score = 212 bits (540), Expect = 7e-55
Identities = 131/379 (34%), Positives = 197/379 (51%), Gaps = 69/379 (18%)
Query: 45 QRKEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALG 104
+RKEKSR+AARSRR KE+ F+ELA LPLP +SS LDKAS++RL+++YLR+R+ G
Sbjct: 17 RRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAG 76
Query: 105 APPWGLRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISE 164
+ + + + L++LDGFV L +G +YIS+
Sbjct: 77 DLD----------------------IEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISD 114
Query: 165 TVSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLA 224
V+ Y+GL+Q E+TG SVFD+ HP DH E+ E L R
Sbjct: 115 NVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRN---------------------- 152
Query: 225 DTPEIEASLTKVPPSSLVQERSFFVRMKSTLTKRG--LHVKASGYKVIHVTGRLRAHALG 282
L K Q RSFF+RMK TLT RG +++K++ +KV+H TG + +
Sbjct: 153 -------GLVKKGKEQNTQ-RSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTN 204
Query: 283 ---------------LVALGHTLPPAPLAELPLHGHMIVFRLSLGLTILACESRVSDHMD 327
LV + +P E+PL + R SL + C+ R+++ M
Sbjct: 205 SNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMG 264
Query: 328 LGPSELVGRSCYQFVHGQDATRIRQSHVDLLDKGQVMTGYYRWLQRAGGFVWLQSVATVA 387
P EL+GRS Y++ H D+ + ++H D+ KGQV TG YR L + GG+VW+++ ATV
Sbjct: 265 YEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVI 324
Query: 388 GSGKSPGEHHVLWVSHVLS 406
+ K+ ++ V++V+S
Sbjct: 325 YNTKNSQPQCIVCVNYVVS 343
>gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a
[Homo sapiens]
Length = 667
Score = 205 bits (522), Expect = 8e-53
Identities = 141/437 (32%), Positives = 213/437 (48%), Gaps = 82/437 (18%)
Query: 46 RKEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGA 105
RKEKSR+AARSRR +E ++LA LP +S+ LDKASI+RL+++YLR+ R A G
Sbjct: 13 RKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAGE 72
Query: 106 PPWGLRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISET 165
W AG + L L++L+GFV L EG Y+SE
Sbjct: 73 --WNQVGAGG--------------------EPLDACYLKALEGFVMVLTAEGDMAYLSEN 110
Query: 166 VSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLAD 225
VS +LGLSQ+E+ G S+FD+IHP D E+ + L
Sbjct: 111 VSKHLGLSQLELIGHSIFDFIHPCDQEELQDAL--------------------------- 143
Query: 226 TPEIEASLTKVPPSSLVQERSFFVRMKSTLTKRG--LHVKASGYKVIHVTGRLRAHALG- 282
TP+ S KV + ER F +RMKSTLT RG L++KA+ +KV++ +G +RA+
Sbjct: 144 TPQQTLSRRKVEAPT---ERCFSLRMKSTLTSRGRTLNLKAATWKVLNCSGHMRAYKPPA 200
Query: 283 ----------------LVALGHTLPPAPLAELPLHGHMIVFRLSLGLTILACESRVSDHM 326
LV + +P E PL + R SL + C+ R+++
Sbjct: 201 QTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVA 260
Query: 327 DLGPSELVGRSCYQFVHGQDATRIRQSHVDLLDKGQVMTGYYRWLQRAGGFVWLQSVATV 386
P +L+G S Y+++H D+ + +S LL KGQ +TG YR+L R+GG++W Q+ ATV
Sbjct: 261 GYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATV 320
Query: 387 AGSGKSPGEHHVLWVSHVLSQAEGGQTPLDAFQLPASVACEEASSPGPEPTEPEPPTEGK 446
G+ P ++ V ++SQ E + ++ E+ P + P++
Sbjct: 321 VSGGRGPQSESIVCVHFLISQVE---------ETGVVLSLEQTEQHSRRPIQRGAPSQ-- 369
Query: 447 QAAPAENEAPQTQGKRI 463
+ P ++ T G RI
Sbjct: 370 KDTPNPGDSLDTPGPRI 386
>gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c
[Homo sapiens]
Length = 669
Score = 205 bits (522), Expect = 8e-53
Identities = 141/437 (32%), Positives = 213/437 (48%), Gaps = 82/437 (18%)
Query: 46 RKEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGA 105
RKEKSR+AARSRR +E ++LA LP +S+ LDKASI+RL+++YLR+ R A G
Sbjct: 15 RKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAGE 74
Query: 106 PPWGLRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISET 165
W AG + L L++L+GFV L EG Y+SE
Sbjct: 75 --WNQVGAGG--------------------EPLDACYLKALEGFVMVLTAEGDMAYLSEN 112
Query: 166 VSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLAD 225
VS +LGLSQ+E+ G S+FD+IHP D E+ + L
Sbjct: 113 VSKHLGLSQLELIGHSIFDFIHPCDQEELQDAL--------------------------- 145
Query: 226 TPEIEASLTKVPPSSLVQERSFFVRMKSTLTKRG--LHVKASGYKVIHVTGRLRAHALG- 282
TP+ S KV + ER F +RMKSTLT RG L++KA+ +KV++ +G +RA+
Sbjct: 146 TPQQTLSRRKVEAPT---ERCFSLRMKSTLTSRGRTLNLKAATWKVLNCSGHMRAYKPPA 202
Query: 283 ----------------LVALGHTLPPAPLAELPLHGHMIVFRLSLGLTILACESRVSDHM 326
LV + +P E PL + R SL + C+ R+++
Sbjct: 203 QTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVA 262
Query: 327 DLGPSELVGRSCYQFVHGQDATRIRQSHVDLLDKGQVMTGYYRWLQRAGGFVWLQSVATV 386
P +L+G S Y+++H D+ + +S LL KGQ +TG YR+L R+GG++W Q+ ATV
Sbjct: 263 GYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATV 322
Query: 387 AGSGKSPGEHHVLWVSHVLSQAEGGQTPLDAFQLPASVACEEASSPGPEPTEPEPPTEGK 446
G+ P ++ V ++SQ E + ++ E+ P + P++
Sbjct: 323 VSGGRGPQSESIVCVHFLISQVE---------ETGVVLSLEQTEQHSRRPIQRGAPSQ-- 371
Query: 447 QAAPAENEAPQTQGKRI 463
+ P ++ T G RI
Sbjct: 372 KDTPNPGDSLDTPGPRI 388
>gi|40254439 endothelial PAS domain protein 1 [Homo sapiens]
Length = 870
Score = 200 bits (509), Expect = 3e-51
Identities = 121/383 (31%), Positives = 201/383 (52%), Gaps = 66/383 (17%)
Query: 45 QRKEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALG 104
+RKEKSR+AAR RR KE F+ELA LPLP ++SS LDKASI+RL++++LR + +
Sbjct: 14 RRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSV 73
Query: 105 APPWGLRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISE 164
A +Q + L++L+GF+ + Q+G +++SE
Sbjct: 74 CSENESEAEA--------------------DQQMDNLYLKALEGFIAVVTQDGDMIFLSE 113
Query: 165 TVSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLA 224
+S ++GL+QVE+TG S+FD+ HP DH E+ E L L+ + S S+
Sbjct: 114 NISKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKNGS-------GFGKKSKDMST-- 164
Query: 225 DTPEIEASLTKVPPSSLVQERSFFVRMKSTLTKRG--LHVKASGYKVIHVTGRLRAH--- 279
ER FF+RMK T+T RG +++K++ +KV+H TG+++ +
Sbjct: 165 -------------------ERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVKVYNNC 205
Query: 280 -------------ALGLVALGHTLPPAPLAELPLHGHMIVFRLSLGLTILACESRVSDHM 326
L+ + + ++PL + R S+ + C+ R+++ +
Sbjct: 206 PPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLDSKTFLSRHSMDMKFTYCDDRITELI 265
Query: 327 DLGPSELVGRSCYQFVHGQDATRIRQSHVDLLDKGQVMTGYYRWLQRAGGFVWLQSVATV 386
P EL+GRS Y+F H D+ + +SH +L KGQV++G YR L + GG+VWL++ TV
Sbjct: 266 GYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTV 325
Query: 387 AGSGKSPGEHHVLWVSHVLSQAE 409
+ ++ ++ V++VLS+ E
Sbjct: 326 IYNPRNLQPQCIMCVNYVLSEIE 348
>gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b
[Homo sapiens]
Length = 613
Score = 162 bits (410), Expect = 8e-40
Identities = 117/395 (29%), Positives = 183/395 (46%), Gaps = 82/395 (20%)
Query: 88 VRLSVTYLRLRRFAALGAPPWGLRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLD 147
+RL+++YLR+ R A G W AG + L L++L+
Sbjct: 1 MRLTISYLRMHRLCAAGE--WNQVGAGG--------------------EPLDACYLKALE 38
Query: 148 GFVFALNQEGKFLYISETVSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPGP 207
GFV L EG Y+SE VS +LGLSQ+E+ G S+FD+IHP D E+ + L
Sbjct: 39 GFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDAL--------- 89
Query: 208 PTPPSVSSSSSSSSSLADTPEIEASLTKVPPSSLVQERSFFVRMKSTLTKRG--LHVKAS 265
TP+ S KV + ER F +RMKSTLT RG L++KA+
Sbjct: 90 ------------------TPQQTLSRRKVEAPT---ERCFSLRMKSTLTSRGRTLNLKAA 128
Query: 266 GYKVIHVTGRLRAHALG-----------------LVALGHTLPPAPLAELPLHGHMIVFR 308
+KV++ +G +RA+ LV + +P E PL + R
Sbjct: 129 TWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSR 188
Query: 309 LSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDLLDKGQVMTGYY 368
SL + C+ R+++ P +L+G S Y+++H D+ + +S LL KGQ +TG Y
Sbjct: 189 HSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQY 248
Query: 369 RWLQRAGGFVWLQSVATVAGSGKSPGEHHVLWVSHVLSQAEGGQTPLDAFQLPASVACEE 428
R+L R+GG++W Q+ ATV G+ P ++ V ++SQ E + ++ E+
Sbjct: 249 RFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVE---------ETGVVLSLEQ 299
Query: 429 ASSPGPEPTEPEPPTEGKQAAPAENEAPQTQGKRI 463
P + P++ + P ++ T G RI
Sbjct: 300 TEQHSRRPIQRGAPSQ--KDTPNPGDSLDTPGPRI 332
>gi|4502003 aryl hydrocarbon receptor [Homo sapiens]
Length = 848
Score = 115 bits (287), Expect = 1e-25
Identities = 108/430 (25%), Positives = 175/430 (40%), Gaps = 54/430 (12%)
Query: 52 NAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRF--AALGAPPWG 109
N ++ R + N E LA LLP P + ++LDK S++RLSV+YLR + F AL + P
Sbjct: 34 NPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSSPTE 93
Query: 110 LRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIY 169
A R G G +LQ+L+GFV + + Y S T+ Y
Sbjct: 94 RNGGQDNCRAANFREG--------LNLQEGEFLLQALNGFVLVVTTDALVFYASSTIQDY 145
Query: 170 LGLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLADTPEI 229
LG Q ++ SV++ IH D +E QL P + S P+
Sbjct: 146 LGFQQSDVIHQSVYELIHTEDRAEFQRQLHWAL------NPSQCTESGQGIEEATGLPQT 199
Query: 230 EASLT--KVPP-SSLVQERSFFVRMKSTLTKRGLHVKASGYKVIHVTGRLR--------- 277
++PP +S + ER F R++ L +SG+ ++ G+L+
Sbjct: 200 VVCYNPDQIPPENSPLMERCFICRLRCLLD------NSSGFLAMNFQGKLKYLHGQKKKG 253
Query: 278 ------AHALGLVALGHTLPPAPLAELPLHGHMIVFRLSLGLTILACESRVSDHMDLGPS 331
L L A+ L P + E+ + + L T + C+++ + +
Sbjct: 254 KDGSILPPQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTEA 313
Query: 332 ELVGR-SCYQFVHGQDATRIRQSHVDLLDKGQVMTGYYRWLQRAGGFVWLQSVATVAGSG 390
EL R S YQF+H D +SH+ ++ G+ +R L + + W+QS A +
Sbjct: 314 ELCTRGSGYQFIHAADMLYCAESHIRMIKTGESGMIVFRLLTKNNRWTWVQSNARLLYKN 373
Query: 391 KSPGEHHVLWVSHVLSQAEGGQ------TPLDAFQLPASVACEEASSPGPEPTEPEP--- 441
P +++ L+ EG + T L EA++P P +P P
Sbjct: 374 GRP--DYIIVTQRPLTDEEGTEHLRKRNTKLPFMFTTGEAVLYEATNPFPAIMDPLPLRT 431
Query: 442 --PTEGKQAA 449
T GK +A
Sbjct: 432 KNGTSGKDSA 441
>gi|31745180 aryl hydrocarbon receptor nuclear translocator-like 2
[Homo sapiens]
Length = 636
Score = 105 bits (262), Expect = 1e-22
Identities = 109/421 (25%), Positives = 181/421 (42%), Gaps = 70/421 (16%)
Query: 47 KEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAP 106
+E + RR K N EL+ ++P ++ +LDK +++R++V +LR +
Sbjct: 109 REAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSLK------- 161
Query: 107 PWGLRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQE-GKFLYISET 165
GL G S + + L IL++ +GF+F + E GK L++S++
Sbjct: 162 -----------GLTNSYVGSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKS 210
Query: 166 VSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLAD 225
VS L Q +TG S+FD++HP D ++V EQL +P + + L
Sbjct: 211 VSKILNYDQASLTGQSLFDFLHPKDVAKVKEQLSSFDISPR-------EKLIDAKTGLQV 263
Query: 226 TPEIEASLTKVPPSSLVQERSFFVRMKSTL------------TKRGLHVKASGYKVIHVT 273
+ A T+V S RSFF R+KS +K+ H K + IH T
Sbjct: 264 HSNLHAGRTRVYSGS---RRSFFCRIKSCKISVKEEHGCLPNSKKKEHRK---FYTIHCT 317
Query: 274 GRLRA---HALG----------------LVALGHTLP---PAPLAELPLHGHMIVFRLSL 311
G LR+ + +G LVA+G P P E+ + + R ++
Sbjct: 318 GYLRSWPPNIVGMEEERNSKKDNSNFTCLVAIGRLQPYIVPQNSGEINVKPTEFITRFAV 377
Query: 312 GLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDLL-DKGQVMTGYYRW 370
+ + R + + P EL+G SCY++ H D + H +L K +++T Y++
Sbjct: 378 NGKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKF 437
Query: 371 LQRAGGFVWLQSVATVAGSGKSPGEHHVLWVSHVLSQAEGGQTPLDAFQLPASVACEEAS 430
+ G FV L+S S +P + ++ V + G P +A LP S E S
Sbjct: 438 RAKDGSFVTLKSQWF---SFTNPWTKELEYIVSVNTLVLGHSEPGEASFLPCSSQSSEES 494
Query: 431 S 431
S
Sbjct: 495 S 495
>gi|71852582 aryl hydrocarbon receptor nuclear translocator-like
isoform b [Homo sapiens]
Length = 582
Score = 99.4 bits (246), Expect = 8e-21
Identities = 102/380 (26%), Positives = 167/380 (43%), Gaps = 80/380 (21%)
Query: 47 KEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAP 106
+E + RR K N ELA L+P A+S +LDK +++R++V +++
Sbjct: 31 REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKT--------- 81
Query: 107 PWGLRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALN-QEGKFLYISET 165
LR A P A + +S+ +HL IL++ DGF+F + GK L++SE+
Sbjct: 82 ---LRGATNPYTEANYK---PTFLSDDELKHL---ILRAADGFLFVVGCDRGKILFVSES 132
Query: 166 VSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLAD 225
V L SQ ++ G S+FDY+HP D ++V EQL SS ++ L D
Sbjct: 133 VFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLS--------------SSDTAPRERLID 178
Query: 226 TP---EIEASLTKVPPSSLVQ--ERSFFVRMK--------------STLTKRGLHVKASG 266
++ +T PS L RSFF RMK ST +K+
Sbjct: 179 AKTGLPVKTDITP-GPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKK---KDRKS 234
Query: 267 YKVIHVTGRLRA-------------------HALGLVALG----HTLPPAPLAELPLHGH 303
+ IH TG L++ + LVA+G H +P E+ +
Sbjct: 235 FCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSM 294
Query: 304 MIVFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDLLD-KGQ 362
V R ++ + + R + + P EL+G SCY++ H D + + H +L + +
Sbjct: 295 EYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREK 354
Query: 363 VMTGYYRWLQRAGGFVWLQS 382
+ T Y++ + G F+ L+S
Sbjct: 355 ITTNCYKFKIKDGSFITLRS 374
>gi|71852580 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 99.4 bits (246), Expect = 8e-21
Identities = 102/380 (26%), Positives = 167/380 (43%), Gaps = 80/380 (21%)
Query: 47 KEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAP 106
+E + RR K N ELA L+P A+S +LDK +++R++V +++
Sbjct: 74 REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKT--------- 124
Query: 107 PWGLRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALN-QEGKFLYISET 165
LR A P A + +S+ +HL IL++ DGF+F + GK L++SE+
Sbjct: 125 ---LRGATNPYTEANYK---PTFLSDDELKHL---ILRAADGFLFVVGCDRGKILFVSES 175
Query: 166 VSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLAD 225
V L SQ ++ G S+FDY+HP D ++V EQL SS ++ L D
Sbjct: 176 VFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLS--------------SSDTAPRERLID 221
Query: 226 TP---EIEASLTKVPPSSLVQ--ERSFFVRMK--------------STLTKRGLHVKASG 266
++ +T PS L RSFF RMK ST +K+
Sbjct: 222 AKTGLPVKTDITP-GPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKK---KDRKS 277
Query: 267 YKVIHVTGRLRA-------------------HALGLVALG----HTLPPAPLAELPLHGH 303
+ IH TG L++ + LVA+G H +P E+ +
Sbjct: 278 FCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSM 337
Query: 304 MIVFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDLLD-KGQ 362
V R ++ + + R + + P EL+G SCY++ H D + + H +L + +
Sbjct: 338 EYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREK 397
Query: 363 VMTGYYRWLQRAGGFVWLQS 382
+ T Y++ + G F+ L+S
Sbjct: 398 ITTNCYKFKIKDGSFITLRS 417
>gi|42716311 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 99.4 bits (246), Expect = 8e-21
Identities = 102/380 (26%), Positives = 167/380 (43%), Gaps = 80/380 (21%)
Query: 47 KEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAP 106
+E + RR K N ELA L+P A+S +LDK +++R++V +++
Sbjct: 74 REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKT--------- 124
Query: 107 PWGLRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALN-QEGKFLYISET 165
LR A P A + +S+ +HL IL++ DGF+F + GK L++SE+
Sbjct: 125 ---LRGATNPYTEANYK---PTFLSDDELKHL---ILRAADGFLFVVGCDRGKILFVSES 175
Query: 166 VSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLAD 225
V L SQ ++ G S+FDY+HP D ++V EQL SS ++ L D
Sbjct: 176 VFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLS--------------SSDTAPRERLID 221
Query: 226 TP---EIEASLTKVPPSSLVQ--ERSFFVRMK--------------STLTKRGLHVKASG 266
++ +T PS L RSFF RMK ST +K+
Sbjct: 222 AKTGLPVKTDITP-GPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKK---KDRKS 277
Query: 267 YKVIHVTGRLRA-------------------HALGLVALG----HTLPPAPLAELPLHGH 303
+ IH TG L++ + LVA+G H +P E+ +
Sbjct: 278 FCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSM 337
Query: 304 MIVFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDLLD-KGQ 362
V R ++ + + R + + P EL+G SCY++ H D + + H +L + +
Sbjct: 338 EYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREK 397
Query: 363 VMTGYYRWLQRAGGFVWLQS 382
+ T Y++ + G F+ L+S
Sbjct: 398 ITTNCYKFKIKDGSFITLRS 417
>gi|115430245 arylhydrocarbon receptor repressor [Homo sapiens]
Length = 719
Score = 91.7 bits (226), Expect = 2e-18
Identities = 69/200 (34%), Positives = 96/200 (48%), Gaps = 27/200 (13%)
Query: 29 LPGLMVKAPSGPCLQAQRKEK-------------SRNAARSRRGKENLEFFELAKLLPLP 75
+P M+ P G C A RK + N ++ R + N E LA LLP P
Sbjct: 1 MPRTMI--PPGECTYAGRKRRRPLQKQRPAVGAEKSNPSKRHRDRLNAELDHLASLLPFP 58
Query: 76 GAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGLR-AAGPPAGLAPGRRGPAALVSEVF 134
I S+LDK S++RLSV+YLR++ F + + AAG P+ PG P A S V
Sbjct: 59 PDIISKLDKLSVLRLSVSYLRVKSFFQVVQEQSSRQPAAGAPS---PGDSCPLA-GSAVL 114
Query: 135 EQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVEMTGSSVFDYIHPGDHSEV 194
E L +L+SL+GF ++ EG Y S T+ YLG Q ++ +++DYIH D +
Sbjct: 115 EGRL---LLESLNGFALVVSAEGTIFYASATIVDYLGFHQTDVMHQNIYDYIHVDDRQDF 171
Query: 195 LEQLGLRTPTP----GPPTP 210
QL P G P P
Sbjct: 172 CRQLHWAMDPPQVVFGQPPP 191
>gi|194097477 neuronal PAS domain protein 4 [Homo sapiens]
Length = 802
Score = 91.7 bits (226), Expect = 2e-18
Identities = 97/350 (27%), Positives = 143/350 (40%), Gaps = 79/350 (22%)
Query: 50 SRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAPPWG 109
++ A+++RR + N E L +LLPL A +L I+ L+ Y R F A G P G
Sbjct: 5 TKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGTPLAG 64
Query: 110 LRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIY 169
P GL L ++ E I+ +L GF+ EGK LY+SE+VS +
Sbjct: 65 ------PTGL---------LSAQELED-----IVAALPGFLLVFTAEGKLLYLSESVSEH 104
Query: 170 LGLSQVEMT--GSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLADTP 227
LG S V++ G S++D I P DH V +QL L
Sbjct: 105 LGHSMVDLVAQGDSIYDIIDPADHLTVRQQLTL--------------------------- 137
Query: 228 EIEASLTKVPPSSLVQERSFFVRMKSTLTKRGLHVKASGYKVIHVTGRLRAHALGLVALG 287
PS+L +R F R T + L +++G K++ + GR AH G G
Sbjct: 138 ----------PSALDTDRLFRCRFN---TSKSLRRQSAGNKLVLIRGRFHAHPPGAYWAG 184
Query: 288 H---TLPPAPLAELPLHG------------HMIVFRLSLGLTILACESRVSDHMDLGPSE 332
+ T APL P G M R + L +L V ++ SE
Sbjct: 185 NPVFTAFCAPLEPRPRPGPGPGPGPASLFLAMFQSRHAKDLALLDISESVLIYLGFERSE 244
Query: 333 LVGRSCYQFVHGQDATRIRQSHVDLL-DKGQVMTGYYRWLQ-RAGGFVWL 380
L+ +S Y +H +D H LL + G + LQ + GG+ W+
Sbjct: 245 LLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQAKTGGWAWI 294
>gi|4758010 clock [Homo sapiens]
Length = 846
Score = 80.5 bits (197), Expect = 4e-15
Identities = 103/461 (22%), Positives = 183/461 (39%), Gaps = 46/461 (9%)
Query: 47 KEKSRNAA-RSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGA 105
K SRN + + RR + N+ EL +LP + ++DK+++++ S+ +LR + +
Sbjct: 35 KRVSRNKSEKKRRDQFNVLIKELGSMLP---GNARKMDKSTVLQKSIDFLRKHKEITAQS 91
Query: 106 PPWGLRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISET 165
+R P L+ +E F Q + L++LDGF A+ +G +Y+SE+
Sbjct: 92 DASEIRQDWKPTFLS----------NEEFTQLM----LEALDGFFLAIMTDGSIIYVSES 137
Query: 166 VSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLAD 225
V+ L ++ S+F++I G+HSEV + L TP + S +
Sbjct: 138 VTSLLEHLPSDLVDQSIFNFIPEGEHSEVYKILSTHLLESDSLTPEYLKSKNQLEFC--- 194
Query: 226 TPEIEASLTKVPPSS--LVQERSFFVRMKSTLTKRGLHVKASGYKVIHVTGRLRAHALGL 283
+ ++ PS+ V+ F + S + + + + + R +
Sbjct: 195 CHMLRGTIDPKEPSTYEYVKFIGNFKSLNSVSSSAHNGFEGTIQRTHRPSYEDRVCFVAT 254
Query: 284 VALGHTLPPAPLAELPLHGHMIVFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVH 343
V L + + R SL L + R + P E++G S Y + H
Sbjct: 255 VRLATPQFIKEMCTVEEPNEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYH 314
Query: 344 GQDATRIRQSHVDLLDKGQVMTGYYRWLQRAGGFVWLQSVATVAGSGKSPGEHHVLWVSH 403
D + + H L+ G+ + YYR+L + ++WLQ+ + + ++
Sbjct: 315 VDDLENLAKCHEHLMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYHQWNSRPEFIVCTHT 374
Query: 404 VLSQAEGGQTPLDAFQLPASVACEEASSPGPEPTEPEPPTEGKQAAPAENEAPQTQGK-- 461
V+S AE V E G E + PE + Q + ++N K
Sbjct: 375 VVSYAE--------------VRAERRRELGIEESLPETAADKSQDSGSDNRINTVSLKEA 420
Query: 462 --RIKVEPGP----RETKGSEDSGDEDPSSHPATPRPEFTS 496
R P P R ++ S + DPSS P T P TS
Sbjct: 421 LERFDHSPTPSASSRSSRKSSHTAVSDPSSTP-TKIPTDTS 460
>gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Homo
sapiens]
Length = 717
Score = 77.0 bits (188), Expect = 4e-14
Identities = 95/436 (21%), Positives = 185/436 (42%), Gaps = 81/436 (18%)
Query: 47 KEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAP 106
+E R RR K EL+ ++P A++ + DK +I+R++V++++
Sbjct: 65 RENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMK---------- 114
Query: 107 PWGLRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQE-GKFLYISET 165
+R G + G P+ L EQ L IL++ DGF+F + E G+ +Y+S++
Sbjct: 115 --SMRGTGNKS--TDGAYKPSFLT----EQELKHLILEAADGFLFVVAAETGRVIYVSDS 166
Query: 166 VSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLAD 225
V+ L Q E GS++++ +HP D ++ EQL +S +S + + D
Sbjct: 167 VTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQL--------------CTSENSMTGRILD 212
Query: 226 ----TPEIEASLTKVPPSSLVQERSFFVRMK--------------STLTKR---GLHVKA 264
T + E + + + RSF RM+ +T+ KR GL
Sbjct: 213 LKTGTVKKEGQQSSM-RMCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVK 271
Query: 265 SG---YKVIHVTGRLRA------------------HALGLVALGHTLPPAPLAELPLHGH 303
G Y V+H TG ++A LVA+G + + ++G
Sbjct: 272 EGEAQYAVVHCTGYIKAWPPAGMTIPEEDADVGQGSKYCLVAIGRLQVTSSPVCMDMNGM 331
Query: 304 MI----VFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDLLD 359
+ + R + I + R + P +L+G+ +F H +D + +R+S ++
Sbjct: 332 SVPTEFLSRHNSDGIITFVDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVK 391
Query: 360 -KGQVMTGYYRWLQRAGGFVWLQSVATVAGSGKSPGEHHVLWVSHVLSQAEGGQTPLDAF 418
KGQV++ YR+ + ++ +++ + + S +++ + + Q + Q L+
Sbjct: 392 LKGQVLSVMYRFRTKNREWMLIRTSSFTFQNPYSDEIEYIICTNTNVKQLQQQQAELEVH 451
Query: 419 QLPASVACEEASSPGP 434
Q + + + P P
Sbjct: 452 QRDGLSSYDLSQVPVP 467
>gi|30795242 aryl hydrocarbon receptor nuclear translocator isoform
3 [Homo sapiens]
Length = 774
Score = 74.3 bits (181), Expect = 3e-13
Identities = 89/375 (23%), Positives = 160/375 (42%), Gaps = 63/375 (16%)
Query: 47 KEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAP 106
+E R RR K EL+ ++P A++ + DK +I+R++V++++
Sbjct: 76 RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMK---------- 125
Query: 107 PWGLRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQE-GKFLYISET 165
LR G + G P+ L +Q L IL++ DGF+F ++ E G+ +Y+S++
Sbjct: 126 --SLRGTGNTS--TDGSYKPSFLT----DQELKHLILEAADGFLFIVSCETGRVVYVSDS 177
Query: 166 VSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQLG------------LRTPTPGPPTPPSV 213
V+ L Q E GS+++D +HP D ++ EQL L+T T S
Sbjct: 178 VTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQS- 236
Query: 214 SSSSSSSSSLADTPEIEASLTKVPPSSLVQERSFFVRMKSTLTKRGLHVKASG---YKVI 270
S S + + + V P S+ R FVR + + GL G + V+
Sbjct: 237 SMRMCMGSRRSFICRMRCGSSSVDPVSV--NRLSFVRNR---CRNGLGSVKDGEPHFVVV 291
Query: 271 HVTGRLRAHALGLVALGHTLPPAPLAE---LPLHGHM-------------------IVFR 308
H TG ++A V+L P A L G + + R
Sbjct: 292 HCTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISR 351
Query: 309 LSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDLLD-KGQVMTGY 367
++ + R + P EL+G++ +F H +D +R S ++ KGQV++
Sbjct: 352 HNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVM 411
Query: 368 YRWLQRAGGFVWLQS 382
+R+ + ++W+++
Sbjct: 412 FRFRSKNQEWLWMRT 426
>gi|4502231 aryl hydrocarbon receptor nuclear translocator isoform 1
[Homo sapiens]
Length = 789
Score = 74.3 bits (181), Expect = 3e-13
Identities = 89/375 (23%), Positives = 160/375 (42%), Gaps = 63/375 (16%)
Query: 47 KEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAP 106
+E R RR K EL+ ++P A++ + DK +I+R++V++++
Sbjct: 91 RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMK---------- 140
Query: 107 PWGLRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQE-GKFLYISET 165
LR G + G P+ L +Q L IL++ DGF+F ++ E G+ +Y+S++
Sbjct: 141 --SLRGTGNTS--TDGSYKPSFLT----DQELKHLILEAADGFLFIVSCETGRVVYVSDS 192
Query: 166 VSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQLG------------LRTPTPGPPTPPSV 213
V+ L Q E GS+++D +HP D ++ EQL L+T T S
Sbjct: 193 VTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQS- 251
Query: 214 SSSSSSSSSLADTPEIEASLTKVPPSSLVQERSFFVRMKSTLTKRGLHVKASG---YKVI 270
S S + + + V P S+ R FVR + + GL G + V+
Sbjct: 252 SMRMCMGSRRSFICRMRCGSSSVDPVSV--NRLSFVRNR---CRNGLGSVKDGEPHFVVV 306
Query: 271 HVTGRLRAHALGLVALGHTLPPAPLAE---LPLHGHM-------------------IVFR 308
H TG ++A V+L P A L G + + R
Sbjct: 307 HCTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISR 366
Query: 309 LSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDLLD-KGQVMTGY 367
++ + R + P EL+G++ +F H +D +R S ++ KGQV++
Sbjct: 367 HNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVM 426
Query: 368 YRWLQRAGGFVWLQS 382
+R+ + ++W+++
Sbjct: 427 FRFRSKNQEWLWMRT 441
>gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens]
Length = 1399
Score = 68.6 bits (166), Expect = 2e-11
Identities = 47/168 (27%), Positives = 88/168 (52%), Gaps = 12/168 (7%)
Query: 55 RSRRGKENLEFFELAKLLPLP----GAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGL 110
+ RR +EN ELA+LL ++S + DK I++ +V ++L + +
Sbjct: 33 KRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMK--RMEQEKSTT 90
Query: 111 RAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYL 170
+ ++ +G + ++ LG +L++LDGF F +N EG+ +++SE V+ YL
Sbjct: 91 DDDVQKSDISSSSQGV------IEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYL 144
Query: 171 GLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSS 218
G +Q E+ +SV+ +H GDH+E ++ L ++ G P P + +S
Sbjct: 145 GYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNS 192
>gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens]
Length = 1440
Score = 68.6 bits (166), Expect = 2e-11
Identities = 47/168 (27%), Positives = 88/168 (52%), Gaps = 12/168 (7%)
Query: 55 RSRRGKENLEFFELAKLLPLP----GAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGL 110
+ RR +EN ELA+LL ++S + DK I++ +V ++L + +
Sbjct: 33 KRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMK--RMEQEKSTT 90
Query: 111 RAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYL 170
+ ++ +G + ++ LG +L++LDGF F +N EG+ +++SE V+ YL
Sbjct: 91 DDDVQKSDISSSSQGV------IEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYL 144
Query: 171 GLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSS 218
G +Q E+ +SV+ +H GDH+E ++ L ++ G P P + +S
Sbjct: 145 GYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNS 192
>gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens]
Length = 1441
Score = 68.6 bits (166), Expect = 2e-11
Identities = 47/168 (27%), Positives = 88/168 (52%), Gaps = 12/168 (7%)
Query: 55 RSRRGKENLEFFELAKLLPLP----GAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGL 110
+ RR +EN ELA+LL ++S + DK I++ +V ++L + +
Sbjct: 33 KRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMK--RMEQEKSTT 90
Query: 111 RAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYL 170
+ ++ +G + ++ LG +L++LDGF F +N EG+ +++SE V+ YL
Sbjct: 91 DDDVQKSDISSSSQGV------IEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYL 144
Query: 171 GLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSS 218
G +Q E+ +SV+ +H GDH+E ++ L ++ G P P + +S
Sbjct: 145 GYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNS 192
>gi|30795240 aryl hydrocarbon receptor nuclear translocator isoform
2 [Homo sapiens]
Length = 328
Score = 65.1 bits (157), Expect = 2e-10
Identities = 45/153 (29%), Positives = 80/153 (52%), Gaps = 19/153 (12%)
Query: 47 KEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAP 106
+E R RR K EL+ ++P A++ + DK +I+R++V++++
Sbjct: 91 RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMK---------- 140
Query: 107 PWGLRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQE-GKFLYISET 165
LR G + G P+ L +Q L IL++ DGF+F ++ E G+ +Y+S++
Sbjct: 141 --SLRGTGNTS--TDGSYKPSFLT----DQELKHLILEAADGFLFIVSCETGRVVYVSDS 192
Query: 166 VSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQL 198
V+ L Q E GS+++D +HP D ++ EQL
Sbjct: 193 VTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQL 225
>gi|5729858 nuclear receptor coactivator 2 [Homo sapiens]
Length = 1464
Score = 58.9 bits (141), Expect = 1e-08
Identities = 26/61 (42%), Positives = 41/61 (67%)
Query: 138 LGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQ 197
LG +L++LDGF F +N EG +++SE V+ YL +Q E+ SV+ +H GDH+E ++
Sbjct: 115 LGPMMLEALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKN 174
Query: 198 L 198
L
Sbjct: 175 L 175
>gi|22027471 neuronal PAS domain protein 2 [Homo sapiens]
Length = 824
Score = 58.9 bits (141), Expect = 1e-08
Identities = 78/354 (22%), Positives = 143/354 (40%), Gaps = 53/354 (14%)
Query: 47 KEKSRNAA-RSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGA 105
K SRN + + RR + N+ EL+ +LP + ++DK +++ + +L+ +
Sbjct: 10 KRASRNKSEKKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGFLQKHNEVSAQT 66
Query: 106 PPWGLRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISET 165
++ P+ L+ +E F Q + L++LDGF+ A+ +G +Y+S++
Sbjct: 67 EICDIQQDWKPSFLS----------NEEFTQLM----LEALDGFIIAVTTDGSIIYVSDS 112
Query: 166 VSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSS------- 218
++ LG ++ ++ +++ +HSEV + L P+P + S S
Sbjct: 113 ITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHL 172
Query: 219 --SSSSLADTPEIE--------ASLTKVPPSSLVQERSFFVRMKSTLTKRGLHVKASGYK 268
S + + P E S VP S +TL+ R V
Sbjct: 173 LRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSC-------NGFDNTLS-RPCRVPLGKEV 224
Query: 269 VIHVTGRLRAHALGLVALGHTLPPAPLAELPLHGHMIVFRLSLGLTILACESRVSDHMDL 328
T RL A L + + PL R SL L + R +
Sbjct: 225 CFIATVRL--------ATPQFLKEMCIVDEPL--EEFTSRHSLEWKFLFLDHRAPPIIGY 274
Query: 329 GPSELVGRSCYQFVHGQDATRIRQSHVDLLDKGQVMTGYYRWLQRAGGFVWLQS 382
P E++G S Y + H D + + H L+ G+ + YR+L + ++WLQ+
Sbjct: 275 LPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQT 328
>gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens]
Length = 1424
Score = 54.7 bits (130), Expect = 2e-07
Identities = 23/61 (37%), Positives = 41/61 (67%)
Query: 138 LGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQ 197
LG +LQ+LDGF+F +N++G +++SE V+ YL Q ++ +SV++ +H D + L+
Sbjct: 113 LGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKN 172
Query: 198 L 198
L
Sbjct: 173 L 173
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.136 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,474,329
Number of Sequences: 37866
Number of extensions: 1869435
Number of successful extensions: 17041
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 102
Number of HSP's successfully gapped in prelim test: 541
Number of HSP's that attempted gapping in prelim test: 13959
Number of HSP's gapped (non-prelim): 3447
length of query: 590
length of database: 18,247,518
effective HSP length: 108
effective length of query: 482
effective length of database: 14,157,990
effective search space: 6824151180
effective search space used: 6824151180
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.