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Search of human proteins with 22027471
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22027471 neuronal PAS domain protein 2 [Homo sapiens]
(824 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22027471 neuronal PAS domain protein 2 [Homo sapiens] 1657 0.0
gi|4758010 clock [Homo sapiens] 748 0.0
gi|71852582 aryl hydrocarbon receptor nuclear translocator-like ... 153 5e-37
gi|71852580 aryl hydrocarbon receptor nuclear translocator-like ... 153 5e-37
gi|42716311 aryl hydrocarbon receptor nuclear translocator-like ... 153 5e-37
gi|30795242 aryl hydrocarbon receptor nuclear translocator isofo... 144 4e-34
gi|4502231 aryl hydrocarbon receptor nuclear translocator isofor... 144 4e-34
gi|40254439 endothelial PAS domain protein 1 [Homo sapiens] 135 2e-31
gi|31745180 aryl hydrocarbon receptor nuclear translocator-like ... 130 6e-30
gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2 ... 128 2e-29
gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1 [... 128 2e-29
gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Ho... 114 4e-25
gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a ... 108 2e-23
gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c ... 108 2e-23
gi|157785548 PAS domain containing 1 [Homo sapiens] 101 3e-21
gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b ... 94 4e-19
gi|21614542 single-minded homolog 1 [Homo sapiens] 93 9e-19
gi|4827004 single-minded homolog 2 long isoform [Homo sapiens] 91 3e-18
gi|194239684 single-minded homolog 2 short isoform [Homo sapiens] 91 3e-18
gi|4502003 aryl hydrocarbon receptor [Homo sapiens] 86 1e-16
gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens] 80 6e-15
gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens] 79 1e-14
gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens] 79 1e-14
gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens] 79 1e-14
gi|30795240 aryl hydrocarbon receptor nuclear translocator isofo... 77 9e-14
gi|5729858 nuclear receptor coactivator 2 [Homo sapiens] 75 3e-13
gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens] 74 4e-13
gi|12707562 period 2 [Homo sapiens] 67 7e-11
gi|8567388 period 3 [Homo sapiens] 63 1e-09
gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens] 61 5e-09
>gi|22027471 neuronal PAS domain protein 2 [Homo sapiens]
Length = 824
Score = 1657 bits (4290), Expect = 0.0
Identities = 824/824 (100%), Positives = 824/824 (100%)
Query: 1 MDEDEKDRAKRASRNKSEKKRRDQFNVLIKELSSMLPGNTRKMDKTTVLEKVIGFLQKHN 60
MDEDEKDRAKRASRNKSEKKRRDQFNVLIKELSSMLPGNTRKMDKTTVLEKVIGFLQKHN
Sbjct: 1 MDEDEKDRAKRASRNKSEKKRRDQFNVLIKELSSMLPGNTRKMDKTTVLEKVIGFLQKHN 60
Query: 61 EVSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPLLGHL 120
EVSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPLLGHL
Sbjct: 61 EVSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPLLGHL 120
Query: 121 PSDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLLRGSLNPK 180
PSDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLLRGSLNPK
Sbjct: 121 PSDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLLRGSLNPK 180
Query: 181 EFPTYEYIKFVGNFRSYNNVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLATPQFLKE 240
EFPTYEYIKFVGNFRSYNNVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLATPQFLKE
Sbjct: 181 EFPTYEYIKFVGNFRSYNNVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLATPQFLKE 240
Query: 241 MCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCH 300
MCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCH
Sbjct: 241 MCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCH 300
Query: 301 QHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVVSYADVRVER 360
QHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVVSYADVRVER
Sbjct: 301 QHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVVSYADVRVER 360
Query: 361 RQELALEDPPSEALHSSALKDKGSSLEPRQHFNTLDVGASGLNTSHSPSASSRSSHKSSH 420
RQELALEDPPSEALHSSALKDKGSSLEPRQHFNTLDVGASGLNTSHSPSASSRSSHKSSH
Sbjct: 361 RQELALEDPPSEALHSSALKDKGSSLEPRQHFNTLDVGASGLNTSHSPSASSRSSHKSSH 420
Query: 421 TAMSEPTSTPTKLMAEASTPALPRSATLPQELPVPGLSQAATMPAPLPSPSSCDLTQQLL 480
TAMSEPTSTPTKLMAEASTPALPRSATLPQELPVPGLSQAATMPAPLPSPSSCDLTQQLL
Sbjct: 421 TAMSEPTSTPTKLMAEASTPALPRSATLPQELPVPGLSQAATMPAPLPSPSSCDLTQQLL 480
Query: 481 PQTVLQSTPAPMAQFSAQFSMFQTIKDQLEQRTRILQANIRWQQEELHKIQEQLCLVQDS 540
PQTVLQSTPAPMAQFSAQFSMFQTIKDQLEQRTRILQANIRWQQEELHKIQEQLCLVQDS
Sbjct: 481 PQTVLQSTPAPMAQFSAQFSMFQTIKDQLEQRTRILQANIRWQQEELHKIQEQLCLVQDS 540
Query: 541 NVQMFLQQPAVSLSFSSTQRPEAQQQLQQRSAAVTQPQLGAGPQLPGQISSAQVTSQHLL 600
NVQMFLQQPAVSLSFSSTQRPEAQQQLQQRSAAVTQPQLGAGPQLPGQISSAQVTSQHLL
Sbjct: 541 NVQMFLQQPAVSLSFSSTQRPEAQQQLQQRSAAVTQPQLGAGPQLPGQISSAQVTSQHLL 600
Query: 601 RESSVISTQGPKPMRSSQLMQSSGRSGSSLVSPFSSATAALPPSLNLTTPASTSQDASQC 660
RESSVISTQGPKPMRSSQLMQSSGRSGSSLVSPFSSATAALPPSLNLTTPASTSQDASQC
Sbjct: 601 RESSVISTQGPKPMRSSQLMQSSGRSGSSLVSPFSSATAALPPSLNLTTPASTSQDASQC 660
Query: 661 QPSPDFSHDRQLRLLLSQPIQPMMPGSCDARQPSEVSRTGRQVKYAQSQTVFQNPDAHPA 720
QPSPDFSHDRQLRLLLSQPIQPMMPGSCDARQPSEVSRTGRQVKYAQSQTVFQNPDAHPA
Sbjct: 661 QPSPDFSHDRQLRLLLSQPIQPMMPGSCDARQPSEVSRTGRQVKYAQSQTVFQNPDAHPA 720
Query: 721 NSSSAPMPVLLMGQAVLHPSFPASQPSPLQPAQARQQPPQHYLQVQAPTSLHSEQQDSLL 780
NSSSAPMPVLLMGQAVLHPSFPASQPSPLQPAQARQQPPQHYLQVQAPTSLHSEQQDSLL
Sbjct: 721 NSSSAPMPVLLMGQAVLHPSFPASQPSPLQPAQARQQPPQHYLQVQAPTSLHSEQQDSLL 780
Query: 781 LSTYSQQPGTLGYPQPPPAQPQPLRPPRRVSSLSESSGLQQPPR 824
LSTYSQQPGTLGYPQPPPAQPQPLRPPRRVSSLSESSGLQQPPR
Sbjct: 781 LSTYSQQPGTLGYPQPPPAQPQPLRPPRRVSSLSESSGLQQPPR 824
>gi|4758010 clock [Homo sapiens]
Length = 846
Score = 748 bits (1931), Expect = 0.0
Identities = 424/837 (50%), Positives = 545/837 (65%), Gaps = 35/837 (4%)
Query: 1 MDEDEKDRAKRASRNKSEKKRRDQFNVLIKELSSMLPGNTRKMDKTTVLEKVIGFLQKHN 60
++ED+KD+AKR SRNKSEKKRRDQFNVLIKEL SMLPGN RKMDK+TVL+K I FL+KH
Sbjct: 26 VEEDDKDKAKRVSRNKSEKKRRDQFNVLIKELGSMLPGNARKMDKSTVLQKSIDFLRKHK 85
Query: 61 EVSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPLLGHL 120
E++AQ++ +I+QDWKP+FLSNEEFTQLMLEALDGF +A+ TDGSIIYVS+S+T LL HL
Sbjct: 86 EITAQSDASEIRQDWKPTFLSNEEFTQLMLEALDGFFLAIMTDGSIIYVSESVTSLLEHL 145
Query: 121 PSDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLLRGSLNPK 180
PSD++DQ++ NF+PE EHSEVYKILS+H+L +DS +PEYLKS + LEF CH+LRG+++PK
Sbjct: 146 PSDLVDQSIFNFIPEGEHSEVYKILSTHLLESDSLTPEYLKSKNQLEFCCHMLRGTIDPK 205
Query: 181 EFPTYEYIKFVGNFRSYNNVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLATPQFLKE 240
E TYEY+KF+GNF+S N+V S + NGF+ T+ R R VCF+ATVRLATPQF+KE
Sbjct: 206 EPSTYEYVKFIGNFKSLNSVSSSAHNGFEGTIQRTHRPSYEDRVCFVATVRLATPQFIKE 265
Query: 241 MCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCH 300
MC V+EP EEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYH+DDLE LA+CH
Sbjct: 266 MCTVEEPNEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVDDLENLAKCH 325
Query: 301 QHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVVSYADVRVER 360
+HLMQ+GKGKSC YRFLTKGQQWIWLQTHYYITYHQWNS+PEFIVCTH+VVSYA+VR ER
Sbjct: 326 EHLMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYHQWNSRPEFIVCTHTVVSYAEVRAER 385
Query: 361 RQELALEDPPSEALHSSALKDKGSSLEPRQHFNTLDVGASGLNTSHSPSASSRSSHKSSH 420
R+EL +E+ E ++A K + S + R + +L + S +PSASSRSS KSSH
Sbjct: 386 RRELGIEESLPE---TAADKSQDSGSDNRINTVSLKEALERFDHSPTPSASSRSSRKSSH 442
Query: 421 TAMSEPTSTPTKLMAEASTPALPRSATLPQELPVPGLSQAATMPAPLPSPSSCDLTQQLL 480
TA+S+P+STPTK+ + STP PR E V S ++ S S LTQ ++
Sbjct: 443 TAVSDPSSTPTKIPTDTSTP--PRQHLPAHEKMVQRRSSFSSQSINSQSVGS-SLTQPVM 499
Query: 481 PQTVLQSTPAPMA--QFSAQFSMFQTIKDQLEQRTRILQANIRWQQEELHKIQEQLCLVQ 538
Q P M+ QFSAQ Q +KDQLEQRTR+++ANI QQEEL KIQEQL +V
Sbjct: 500 SQATNLPIPQGMSQFQFSAQLGAMQHLKDQLEQRTRMIEANIHRQQEELRKIQEQLQMVH 559
Query: 539 DSNVQMFLQQPAVSLSFSSTQRPEA-QQQLQQRSAAVTQPQLGAGPQLPGQISSAQV-TS 596
+QMFLQQ L+F S Q +QQ + Q Q+ Q+ +++ + T+
Sbjct: 560 GQGLQMFLQQSNPGLNFGSVQLSSGNSSNIQQLAPINMQGQVVPTNQIQSGMNTGHIGTT 619
Query: 597 QHLLRESSV--ISTQGPKPMRSSQLMQSS--GRSGSSLVSPFSSATAALPPSLN--LTTP 650
QH++++ ++ STQ + + S Q+S ++ S+L +P + P+ + P
Sbjct: 620 QHMIQQQTLQSTSTQSQQNVLSGHSQQTSLPSQTQSTLTAPLYNTMVISQPAAGSMVQIP 679
Query: 651 ASTSQDASQCQPSPDFSHDRQLRLLLSQPIQPMM---PGSCDARQPSEVSRTGRQVKYAQ 707
+S Q+++Q F+ DRQ+R Q + + P +C A G
Sbjct: 680 SSMPQNSTQSAAVTTFTQDRQIRFSQGQQLVTKLVTAPVACGAVMVPSTMLMG------- 732
Query: 708 SQTVFQNPDAHPANSSSAPMPVLLMGQAVLHPSFPASQPSPLQPAQAR-QQPPQHYLQVQ 766
Q V P S + V Q S S QP+QA+ QPPQ +LQ
Sbjct: 733 -QVVTAYPTFATQQQQSQTLSVTQQQQQ--QSSQEQQLTSVQQPSQAQLTQPPQQFLQTS 789
Query: 767 APTSLHSEQQDSLLLS-TYSQQPGTL--GYPQPPPAQPQPLRPPRRVSSLSESSGLQ 820
LH L+LS + Q T + Q +Q Q R SL + S +Q
Sbjct: 790 --RLLHGNPSTQLILSAAFPLQQSTFPQSHHQQHQSQQQQQLSRHRTDSLPDPSKVQ 844
>gi|71852582 aryl hydrocarbon receptor nuclear translocator-like
isoform b [Homo sapiens]
Length = 582
Score = 153 bits (387), Expect = 5e-37
Identities = 116/388 (29%), Positives = 199/388 (51%), Gaps = 68/388 (17%)
Query: 11 RASRNKSEKKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGFLQK-HNEVSAQT 66
R + ++ EK+RRD+ N I EL+S++P +RK+DK TVL + ++ + T
Sbjct: 31 REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYT 90
Query: 67 EICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTD-GSIIYVSDSITPLLGHLPSDVM 125
E ++KP+FLS++E L+L A DGF+ V D G I++VS+S+ +L + +D++
Sbjct: 91 EA-----NYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLI 145
Query: 126 DQNLLNFLPEQEHSEVYKILSSH---------------MLVTD-SPSPEYLKSDSDLEFY 169
Q+L ++L ++ ++V + LSS + TD +P P L S + F+
Sbjct: 146 GQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFF 205
Query: 170 CHLLRG----SLNPKEFPT----------YEYIKFVGNFRSYNNVPSPSCNGFDNTL--- 212
C + + K+FP+ + I G +S+ P+ G D
Sbjct: 206 CRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSW----PPTKMGLDEDNEPD 261
Query: 213 SRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLE--------EFTSRHSLEWKFLFL 264
+ C + C +A RL + +V +P+ E+ SRH+++ KF+F+
Sbjct: 262 NEGCNLS-----CLVAIGRLHSH-------VVPQPVNGEIRVKSMEYVSRHAIDGKFVFV 309
Query: 265 DHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQF-GKGKSCCYRFLTKGQQW 323
D RA I+ YLP E+LGTS Y+Y+H DD+ LA CH+ ++Q K + CY+F K +
Sbjct: 310 DQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSF 369
Query: 324 IWLQTHYYITYHQWNSKPEFIVCTHSVV 351
I L++ ++ + W + E+IV T++VV
Sbjct: 370 ITLRSRWFSFMNPWTKEVEYIVSTNTVV 397
>gi|71852580 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 153 bits (387), Expect = 5e-37
Identities = 116/388 (29%), Positives = 199/388 (51%), Gaps = 68/388 (17%)
Query: 11 RASRNKSEKKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGFLQK-HNEVSAQT 66
R + ++ EK+RRD+ N I EL+S++P +RK+DK TVL + ++ + T
Sbjct: 74 REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYT 133
Query: 67 EICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTD-GSIIYVSDSITPLLGHLPSDVM 125
E ++KP+FLS++E L+L A DGF+ V D G I++VS+S+ +L + +D++
Sbjct: 134 EA-----NYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLI 188
Query: 126 DQNLLNFLPEQEHSEVYKILSSH---------------MLVTD-SPSPEYLKSDSDLEFY 169
Q+L ++L ++ ++V + LSS + TD +P P L S + F+
Sbjct: 189 GQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFF 248
Query: 170 CHLLRG----SLNPKEFPT----------YEYIKFVGNFRSYNNVPSPSCNGFDNTL--- 212
C + + K+FP+ + I G +S+ P+ G D
Sbjct: 249 CRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSW----PPTKMGLDEDNEPD 304
Query: 213 SRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLE--------EFTSRHSLEWKFLFL 264
+ C + C +A RL + +V +P+ E+ SRH+++ KF+F+
Sbjct: 305 NEGCNLS-----CLVAIGRLHSH-------VVPQPVNGEIRVKSMEYVSRHAIDGKFVFV 352
Query: 265 DHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQF-GKGKSCCYRFLTKGQQW 323
D RA I+ YLP E+LGTS Y+Y+H DD+ LA CH+ ++Q K + CY+F K +
Sbjct: 353 DQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSF 412
Query: 324 IWLQTHYYITYHQWNSKPEFIVCTHSVV 351
I L++ ++ + W + E+IV T++VV
Sbjct: 413 ITLRSRWFSFMNPWTKEVEYIVSTNTVV 440
>gi|42716311 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 153 bits (387), Expect = 5e-37
Identities = 116/388 (29%), Positives = 199/388 (51%), Gaps = 68/388 (17%)
Query: 11 RASRNKSEKKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGFLQK-HNEVSAQT 66
R + ++ EK+RRD+ N I EL+S++P +RK+DK TVL + ++ + T
Sbjct: 74 REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYT 133
Query: 67 EICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTD-GSIIYVSDSITPLLGHLPSDVM 125
E ++KP+FLS++E L+L A DGF+ V D G I++VS+S+ +L + +D++
Sbjct: 134 EA-----NYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLI 188
Query: 126 DQNLLNFLPEQEHSEVYKILSSH---------------MLVTD-SPSPEYLKSDSDLEFY 169
Q+L ++L ++ ++V + LSS + TD +P P L S + F+
Sbjct: 189 GQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFF 248
Query: 170 CHLLRG----SLNPKEFPT----------YEYIKFVGNFRSYNNVPSPSCNGFDNTL--- 212
C + + K+FP+ + I G +S+ P+ G D
Sbjct: 249 CRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSW----PPTKMGLDEDNEPD 304
Query: 213 SRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLE--------EFTSRHSLEWKFLFL 264
+ C + C +A RL + +V +P+ E+ SRH+++ KF+F+
Sbjct: 305 NEGCNLS-----CLVAIGRLHSH-------VVPQPVNGEIRVKSMEYVSRHAIDGKFVFV 352
Query: 265 DHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQF-GKGKSCCYRFLTKGQQW 323
D RA I+ YLP E+LGTS Y+Y+H DD+ LA CH+ ++Q K + CY+F K +
Sbjct: 353 DQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSF 412
Query: 324 IWLQTHYYITYHQWNSKPEFIVCTHSVV 351
I L++ ++ + W + E+IV T++VV
Sbjct: 413 ITLRSRWFSFMNPWTKEVEYIVSTNTVV 440
>gi|30795242 aryl hydrocarbon receptor nuclear translocator isoform
3 [Homo sapiens]
Length = 774
Score = 144 bits (362), Expect = 4e-34
Identities = 147/559 (26%), Positives = 240/559 (42%), Gaps = 78/559 (13%)
Query: 4 DEKDRAKRASRNKSEKKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGFLQKHN 60
++K+R R + ++ E++RR++ I ELS M+P RK DK T+L + H
Sbjct: 69 NDKERFARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVS----HM 124
Query: 61 EVSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTD-GSIIYVSDSITPLLGH 119
+ T +KPSFL+++E L+LEA DGF+ V+ + G ++YVSDS+TP+L
Sbjct: 125 KSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQ 184
Query: 120 LPSDVMDQNLLNFLPEQEHSEVYKILSSHM---------LVTDSPSPEYLKSD------S 164
S+ L + + + ++ + LS+ L T + E +S S
Sbjct: 185 PQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGS 244
Query: 165 DLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPS----------CNGFDNTLSR 214
F C + GS + + + FV N R N + S C G+
Sbjct: 245 RRSFICRMRCGSSSVDPV-SVNRLSFVRN-RCRNGLGSVKDGEPHFVVVHCTGYIKAWP- 301
Query: 215 PCRVPL---------GKEVCFIATVRLATPQF--LKEMCIVDEPLEEFTSRHSLEWKFLF 263
P V L G + C +A RL +M V +P E F SRH++E F F
Sbjct: 302 PAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTE-FISRHNIEGIFTF 360
Query: 264 LDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQF-GKGKSCCYRFLTKGQQ 322
+DHR +GY P E+LG + ++ H +D +LL Q +++ G+ S +RF +K Q+
Sbjct: 361 VDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQE 420
Query: 323 WIWLQTHYYITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDK 382
W+W++T + + ++ + E+I+CT++ V + ++ P + L+
Sbjct: 421 WLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIQRPQLGPTANLPLEMG 480
Query: 383 GSSLEPRQHFNTLDV----GASGL-NTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEA 437
L PRQ ++ G GL + +HS ++ H S+P L A+
Sbjct: 481 SGQLAPRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEH---SKPLEKSDGLFAQD 537
Query: 438 STPALPR--------------SATLP--QELPVPGLSQAATMPAPLPSPSSCDLTQQLLP 481
P S+T+P Q+L SQ T P P P P+ L P
Sbjct: 538 RDPRFSEIYHNINADQSKGISSSTVPATQQL----FSQGNTFP-PTPRPAENFRNSGLAP 592
Query: 482 QTVLQSTPAPMAQFSAQFS 500
+ A Q AQ S
Sbjct: 593 PVTIVQPSASAGQMLAQIS 611
>gi|4502231 aryl hydrocarbon receptor nuclear translocator isoform 1
[Homo sapiens]
Length = 789
Score = 144 bits (362), Expect = 4e-34
Identities = 147/558 (26%), Positives = 239/558 (42%), Gaps = 78/558 (13%)
Query: 5 EKDRAKRASRNKSEKKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGFLQKHNE 61
+K+R R + ++ E++RR++ I ELS M+P RK DK T+L + H +
Sbjct: 85 DKERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVS----HMK 140
Query: 62 VSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTD-GSIIYVSDSITPLLGHL 120
T +KPSFL+++E L+LEA DGF+ V+ + G ++YVSDS+TP+L
Sbjct: 141 SLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQP 200
Query: 121 PSDVMDQNLLNFLPEQEHSEVYKILSSHM---------LVTDSPSPEYLKSD------SD 165
S+ L + + + ++ + LS+ L T + E +S S
Sbjct: 201 QSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSR 260
Query: 166 LEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPS----------CNGFDNTLSRP 215
F C + GS + + + FV N R N + S C G+ P
Sbjct: 261 RSFICRMRCGSSSVDPV-SVNRLSFVRN-RCRNGLGSVKDGEPHFVVVHCTGYIKAWP-P 317
Query: 216 CRVPL---------GKEVCFIATVRLATPQF--LKEMCIVDEPLEEFTSRHSLEWKFLFL 264
V L G + C +A RL +M V +P E F SRH++E F F+
Sbjct: 318 AGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTE-FISRHNIEGIFTFV 376
Query: 265 DHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQF-GKGKSCCYRFLTKGQQW 323
DHR +GY P E+LG + ++ H +D +LL Q +++ G+ S +RF +K Q+W
Sbjct: 377 DHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEW 436
Query: 324 IWLQTHYYITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKG 383
+W++T + + ++ + E+I+CT++ V + ++ P + L+
Sbjct: 437 LWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIQRPQLGPTANLPLEMGS 496
Query: 384 SSLEPRQHFNTLDV----GASGL-NTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEAS 438
L PRQ ++ G GL + +HS ++ H S+P L A+
Sbjct: 497 GQLAPRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEH---SKPLEKSDGLFAQDR 553
Query: 439 TPALPR--------------SATLP--QELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQ 482
P S+T+P Q+L SQ T P P P P+ L P
Sbjct: 554 DPRFSEIYHNINADQSKGISSSTVPATQQL----FSQGNTFP-PTPRPAENFRNSGLAPP 608
Query: 483 TVLQSTPAPMAQFSAQFS 500
+ A Q AQ S
Sbjct: 609 VTIVQPSASAGQMLAQIS 626
>gi|40254439 endothelial PAS domain protein 1 [Homo sapiens]
Length = 870
Score = 135 bits (339), Expect = 2e-31
Identities = 133/556 (23%), Positives = 232/556 (41%), Gaps = 87/556 (15%)
Query: 5 EKDRAKRASRNKSEKKR------RDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGF 55
+K++ + +S + EK R R + + EL+ LP + +DK +++ I F
Sbjct: 4 DKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISF 63
Query: 56 LQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITP 115
L+ H +S+ +C + + +++ L L+AL+GFI VT DG +I++S++I+
Sbjct: 64 LRTHKLLSS---VCSENESEAEA---DQQMDNLYLKALEGFIAVVTQDGDMIFLSENISK 117
Query: 116 LLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSD--LEFYCHLL 173
+G ++ ++ +F +H E+ + LS + + ++ D + C +
Sbjct: 118 FMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVT 177
Query: 174 -RGSLNPKEFPTYEYIKFVGNFRSYNNVPSP-SCNGFDNTLSRPCRVPLGKEVCFIATVR 231
RG + T++ + G + YNN P S G+ KE +
Sbjct: 178 NRGRTVNLKSATWKVLHCTGQVKVYNNCPPHNSLCGY-------------KEPLLSCLII 224
Query: 232 LATPQFLKEMCIVDEPLEE--FTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYH 289
+ P ++ +D PL+ F SRHS++ KF + D R +IGY P E+LG S Y++YH
Sbjct: 225 MCEP--IQHPSHMDIPLDSKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYH 282
Query: 290 IDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHS 349
D E + + HQ+L G+ S YR L K ++WL+T + Y+ N +P+ I+C +
Sbjct: 283 ALDSENMTKSHQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNY 342
Query: 350 VVSYA---DVRVERRQELALEDPPSEALHS-------SALKDKGSSL------------- 386
V+S DV Q +L P A++S A+ +K + L
Sbjct: 343 VLSEIEKNDVVFSMDQTESLFKPHLMAMNSIFDSSGKGAVSEKSNFLFTKLKEEPEELAQ 402
Query: 387 ---EPRQHFNTLDVGASGLNTSHS------PSASSRSSHKSSHTAMSEPTSTPTKLMAEA 437
P +LD G S + P + ++ SH+ SE S P + +A
Sbjct: 403 LAPTPGDAIISLDFGNQNFEESSAYGKAILPPSQPWATELRSHSTQSEAGSLPAFTVPQA 462
Query: 438 STPALPRSATLPQELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSA 497
+ P +T P+ S SSC +
Sbjct: 463 AAP-------------------GSTTPSATSSSSSCSTPNSPEDYYTSLDNDLKIEVIEK 503
Query: 498 QFSMFQTIKDQLEQRT 513
F+M KDQ +T
Sbjct: 504 LFAMDTEAKDQCSTQT 519
>gi|31745180 aryl hydrocarbon receptor nuclear translocator-like 2
[Homo sapiens]
Length = 636
Score = 130 bits (326), Expect = 6e-30
Identities = 104/382 (27%), Positives = 190/382 (49%), Gaps = 49/382 (12%)
Query: 6 KDRAKRASRNKSEKKRRDQFNVLIKELSSMLPG---NTRKMDKTTVLEKVIGFLQKHNEV 62
K +A R + +++EK+RRD+ N LI+ELS+M+P RK+DK TVL + L+ +
Sbjct: 104 KMKAFREAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSLKGL 163
Query: 63 SAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTD-GSIIYVSDSITPLLGHLP 121
+ + +++PSFL + E L+L+ +GF+ V + G I++VS S++ +L +
Sbjct: 164 TNSY----VGSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQ 219
Query: 122 SDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLE-------------- 167
+ + Q+L +FL ++ ++V + LSS + SP + + + + L+
Sbjct: 220 ASLTGQSLFDFLHPKDVAKVKEQLSSFDI---SPREKLIDAKTGLQVHSNLHAGRTRVYS 276
Query: 168 -----FYCHLLRGSLNPKE-------FPTYEYIKF-----VGNFRSYNNVPSPSCNGFDN 210
F+C + ++ KE E+ KF G RS+ P+ G +
Sbjct: 277 GSRRSFFCRIKSCKISVKEEHGCLPNSKKKEHRKFYTIHCTGYLRSW----PPNIVGMEE 332
Query: 211 TLSRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPP 270
R + C +A RL + ++ EF +R ++ KF+++D RA
Sbjct: 333 --ERNSKKDNSNFTCLVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRATA 390
Query: 271 IIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQF-GKGKSCCYRFLTKGQQWIWLQTH 329
I+GYLP E+LGTS Y+Y+H DD L H+ ++Q K + Y+F K ++ L++
Sbjct: 391 ILGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQ 450
Query: 330 YYITYHQWNSKPEFIVCTHSVV 351
++ + W + E+IV +++V
Sbjct: 451 WFSFTNPWTKELEYIVSVNTLV 472
>gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2
[Homo sapiens]
Length = 735
Score = 128 bits (322), Expect = 2e-29
Identities = 132/523 (25%), Positives = 223/523 (42%), Gaps = 73/523 (13%)
Query: 7 DRAKRASRNKSEKKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGFLQKHNEVS 63
+R K SR+ + +R + V EL+ LP + +DK +V+ I +L+ +
Sbjct: 16 ERRKEKSRDAARSRRSKESEVFY-ELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLD 74
Query: 64 AQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPLLGHLPSD 123
A DI+ D K + L+ALDGF++ +T DG +IY+SD++ +G +
Sbjct: 75 AGD--LDIEDDMKA------QMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFE 126
Query: 124 VMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLL-RGSLNPKEF 182
+ ++ +F +H E+ ++L+ + + + L C L RG +
Sbjct: 127 LTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKS 186
Query: 183 PTYEYIKFVGNFRSYN-NVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLATPQFLKEM 241
T++ + G+ Y+ N P C G+ K+ V + P +
Sbjct: 187 ATWKVLHCTGHIHVYDTNSNQPQC-GY-------------KKPPMTCLVLICEP--IPHP 230
Query: 242 CIVDEPLEE--FTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARC 299
++ PL+ F SRHSL+ KF + D R ++GY P E+LG S Y+YYH D + L +
Sbjct: 231 SNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKT 290
Query: 300 HQHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVVS---YADV 356
H + G+ + YR L K ++W++T + Y+ NS+P+ IVC + VVS D+
Sbjct: 291 HHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDL 350
Query: 357 RVERRQ-ELALEDPPSEALHSSALKDKGSSLEPRQHFN---------------------T 394
+Q E L+ S + + L K S + F+ +
Sbjct: 351 IFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIIS 410
Query: 395 LDVGASGLNTSHSP-----------SASSRSSHKSSHTAMSE-PTSTPTKLMAEASTPAL 442
LD G++ T S ++ + AMS PT+ K + ++ PAL
Sbjct: 411 LDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPAL 470
Query: 443 PRSATLPQELPVPGLSQAATMPA---PLPSPSSCDLTQQLLPQ 482
+ L E L + TMP PSPS T+Q P+
Sbjct: 471 NQEVALKLEPNPESLELSFTMPQIQDQTPSPSD-GSTRQSSPE 512
>gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1
[Homo sapiens]
Length = 826
Score = 128 bits (322), Expect = 2e-29
Identities = 132/523 (25%), Positives = 223/523 (42%), Gaps = 73/523 (13%)
Query: 7 DRAKRASRNKSEKKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGFLQKHNEVS 63
+R K SR+ + +R + V EL+ LP + +DK +V+ I +L+ +
Sbjct: 16 ERRKEKSRDAARSRRSKESEVFY-ELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLD 74
Query: 64 AQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPLLGHLPSD 123
A DI+ D K + L+ALDGF++ +T DG +IY+SD++ +G +
Sbjct: 75 AGD--LDIEDDMKA------QMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFE 126
Query: 124 VMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLL-RGSLNPKEF 182
+ ++ +F +H E+ ++L+ + + + L C L RG +
Sbjct: 127 LTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKS 186
Query: 183 PTYEYIKFVGNFRSYN-NVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLATPQFLKEM 241
T++ + G+ Y+ N P C G+ K+ V + P +
Sbjct: 187 ATWKVLHCTGHIHVYDTNSNQPQC-GY-------------KKPPMTCLVLICEP--IPHP 230
Query: 242 CIVDEPLEE--FTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARC 299
++ PL+ F SRHSL+ KF + D R ++GY P E+LG S Y+YYH D + L +
Sbjct: 231 SNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKT 290
Query: 300 HQHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVVS---YADV 356
H + G+ + YR L K ++W++T + Y+ NS+P+ IVC + VVS D+
Sbjct: 291 HHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDL 350
Query: 357 RVERRQ-ELALEDPPSEALHSSALKDKGSSLEPRQHFN---------------------T 394
+Q E L+ S + + L K S + F+ +
Sbjct: 351 IFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIIS 410
Query: 395 LDVGASGLNTSHSP-----------SASSRSSHKSSHTAMSE-PTSTPTKLMAEASTPAL 442
LD G++ T S ++ + AMS PT+ K + ++ PAL
Sbjct: 411 LDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPAL 470
Query: 443 PRSATLPQELPVPGLSQAATMPA---PLPSPSSCDLTQQLLPQ 482
+ L E L + TMP PSPS T+Q P+
Sbjct: 471 NQEVALKLEPNPESLELSFTMPQIQDQTPSPSD-GSTRQSSPE 512
>gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Homo
sapiens]
Length = 717
Score = 114 bits (285), Expect = 4e-25
Identities = 112/415 (26%), Positives = 181/415 (43%), Gaps = 56/415 (13%)
Query: 2 DEDEKDRAKRASRNKSE--KKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGFL 56
DED + +K + N SE ++RR++ I ELS M+P RK DK T+L + +
Sbjct: 54 DEDGEGPSKFSRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHM 113
Query: 57 QKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTD-GSIIYVSDSITP 115
+ ++ +KPSFL+ +E L+LEA DGF+ V + G +IYVSDS+TP
Sbjct: 114 KSMRGTGNKST----DGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTP 169
Query: 116 LLGHLPSDVMDQNL--------LNFLPEQ----EHSEVYKILSSHMLVTDSPSPEYLKSD 163
+L S+ L + L EQ E+S +IL L T + E +S
Sbjct: 170 VLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILD---LKTGTVKKEGQQSS 226
Query: 164 ------SDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRS--------YNNVPSPSCNGFD 209
S F C + G+ P FR+ C G+
Sbjct: 227 MRMCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYI 286
Query: 210 NTL--------SRPCRVPLGKEVCFIATVRL--ATPQFLKEMCIVDEPLEEFTSRHSLEW 259
V G + C +A RL + +M + P EF SRH+ +
Sbjct: 287 KAWPPAGMTIPEEDADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVP-TEFLSRHNSDG 345
Query: 260 KFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQF-GKGKSCCYRFLT 318
F+D R +IGY P ++LG ++ H +D L Q +++ G+ S YRF T
Sbjct: 346 IITFVDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRT 405
Query: 319 KGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVV-----SYADVRVERRQELALED 368
K ++W+ ++T + + ++ + E+I+CT++ V A++ V +R L+ D
Sbjct: 406 KNREWMLIRTSSFTFQNPYSDEIEYIICTNTNVKQLQQQQAELEVHQRDGLSSYD 460
>gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a
[Homo sapiens]
Length = 667
Score = 108 bits (270), Expect = 2e-23
Identities = 115/474 (24%), Positives = 200/474 (42%), Gaps = 54/474 (11%)
Query: 3 EDEKDRAKRASRNKSEKKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGFLQKH 59
E K++++ A+R+ RR Q ++ +L+ LP G + +DK +++ I +L+ H
Sbjct: 11 ELRKEKSRDAARS-----RRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMH 65
Query: 60 NEVSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPLLGH 119
+A +W E L+AL+GF++ +T +G + Y+S++++ LG
Sbjct: 66 RLCAAG--------EWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGL 117
Query: 120 LPSDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLL-RGSLN 178
+++ ++ +F+ + E+ L+ ++ + L L RG
Sbjct: 118 SQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTL 177
Query: 179 PKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLATPQFL 238
+ T++ + G+ R+Y S G + S P PL C + + +
Sbjct: 178 NLKAATWKVLNCSGHMRAYKPPAQTSPAGSPD--SEP---PLQ---CLVLIC-----EAI 224
Query: 239 KEMCIVDEPLEE--FTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELL 296
++ PL F SRHSL+ KF + D R + GY P +++G S Y+Y H D + +
Sbjct: 225 PHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAV 284
Query: 297 ARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVVSYADV 356
++ L+ G+ + YRFL + ++W QT + + E IVC H ++S +
Sbjct: 285 SKSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVE- 343
Query: 357 RVERRQELALEDPPSEALHSSALKDKG--SSLEPRQHFNTLDV-GASGLNTSHSPSASSR 413
E L+LE HS +G S + ++LD G L H PS S
Sbjct: 344 --ETGVVLSLEQTEQ---HSRRPIQRGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEA 398
Query: 414 SSHKSSHTAMSE-------PTSTPTKLMAEASTPAL------PRSATLPQELPV 454
+ S P + A STP P SA LP ELPV
Sbjct: 399 ALAADPRRFCSPDLRRLLGPILDGASVAATPSTPLATRHPQSPLSADLPDELPV 452
>gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c
[Homo sapiens]
Length = 669
Score = 108 bits (270), Expect = 2e-23
Identities = 115/474 (24%), Positives = 200/474 (42%), Gaps = 54/474 (11%)
Query: 3 EDEKDRAKRASRNKSEKKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGFLQKH 59
E K++++ A+R+ RR Q ++ +L+ LP G + +DK +++ I +L+ H
Sbjct: 13 ELRKEKSRDAARS-----RRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMH 67
Query: 60 NEVSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPLLGH 119
+A +W E L+AL+GF++ +T +G + Y+S++++ LG
Sbjct: 68 RLCAAG--------EWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGL 119
Query: 120 LPSDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLL-RGSLN 178
+++ ++ +F+ + E+ L+ ++ + L L RG
Sbjct: 120 SQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTL 179
Query: 179 PKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLATPQFL 238
+ T++ + G+ R+Y S G + S P PL C + + +
Sbjct: 180 NLKAATWKVLNCSGHMRAYKPPAQTSPAGSPD--SEP---PLQ---CLVLIC-----EAI 226
Query: 239 KEMCIVDEPLEE--FTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELL 296
++ PL F SRHSL+ KF + D R + GY P +++G S Y+Y H D + +
Sbjct: 227 PHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAV 286
Query: 297 ARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVVSYADV 356
++ L+ G+ + YRFL + ++W QT + + E IVC H ++S +
Sbjct: 287 SKSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVE- 345
Query: 357 RVERRQELALEDPPSEALHSSALKDKG--SSLEPRQHFNTLDV-GASGLNTSHSPSASSR 413
E L+LE HS +G S + ++LD G L H PS S
Sbjct: 346 --ETGVVLSLEQTEQ---HSRRPIQRGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEA 400
Query: 414 SSHKSSHTAMSE-------PTSTPTKLMAEASTPAL------PRSATLPQELPV 454
+ S P + A STP P SA LP ELPV
Sbjct: 401 ALAADPRRFCSPDLRRLLGPILDGASVAATPSTPLATRHPQSPLSADLPDELPV 454
>gi|157785548 PAS domain containing 1 [Homo sapiens]
Length = 773
Score = 101 bits (251), Expect = 3e-21
Identities = 73/228 (32%), Positives = 116/228 (50%), Gaps = 39/228 (17%)
Query: 58 KHNEVSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPLL 117
K N S+Q ++ +W PSF + + F Q+ L+ LDGF+I ++TDG II V+++I+ LL
Sbjct: 11 KVNPKSSQRKL-----NWIPSFPTYDYFNQVTLQLLDGFMITLSTDGVIICVAENISSLL 65
Query: 118 GHLPSDVMDQNLLNFLPEQEHSEVY-KILSSHMLVTDSPSPEYLKSDSDLEFYCHLLRGS 176
GHLP++++ + LL+ LP++E EVY KI+ L L S++ +EF CHL RG+
Sbjct: 66 GHLPAEIVGKKLLSLLPDEEKDEVYQKIILKFPL---------LNSETHIEFCCHLKRGN 116
Query: 177 LNPKEFPTYEYIKFVGNFRSYNN---------VPSPSCNGFDNTLSRPCRVPLGKEVCFI 227
+ + YE +KF+ N R N S C F + + R+ L VC +
Sbjct: 117 VEHGDSSAYENVKFIVNVRDICNEFPVVFSGLFSSHLCADFAACVPQEDRLYLVGNVCIL 176
Query: 228 ATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGYL 275
T Q L+++ +TS+ + L D P +G L
Sbjct: 177 RT------QLLQQL---------YTSKAVSDEAVLTQDSDEEPFVGEL 209
Score = 35.4 bits (80), Expect = 0.22
Identities = 28/85 (32%), Positives = 40/85 (47%), Gaps = 2/85 (2%)
Query: 451 ELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQ-STPAPMAQFSAQFSMFQTIKDQL 509
E PV L QA M P+ S DL LQ S+P S + + + +K+QL
Sbjct: 326 ENPVAPLDQAGLMD-PVDPEDSVDLGAAGASAQPLQPSSPVAYDIISQELELMKKLKEQL 384
Query: 510 EQRTRILQANIRWQQEELHKIQEQL 534
E+RT +L I+ QQ L + + L
Sbjct: 385 EERTWLLHDAIQNQQNALELMMDHL 409
>gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b
[Homo sapiens]
Length = 613
Score = 94.4 bits (233), Expect = 4e-19
Identities = 98/400 (24%), Positives = 165/400 (41%), Gaps = 38/400 (9%)
Query: 74 DWKPSFLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFL 133
+W E L+AL+GF++ +T +G + Y+S++++ LG +++ ++ +F+
Sbjct: 18 EWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFI 77
Query: 134 PEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLL-RGSLNPKEFPTYEYIKFVG 192
+ E+ L+ ++ + L L RG + T++ + G
Sbjct: 78 HPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKAATWKVLNCSG 137
Query: 193 NFRSYNNVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLEE-- 250
+ R+Y S G + S P PL C + + + ++ PL
Sbjct: 138 HMRAYKPPAQTSPAGSPD--SEP---PLQ---CLVLIC-----EAIPHPGSLEPPLGRGA 184
Query: 251 FTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGK 310
F SRHSL+ KF + D R + GY P +++G S Y+Y H D + +++ L+ G+
Sbjct: 185 FLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAV 244
Query: 311 SCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPP 370
+ YRFL + ++W QT + + E IVC H ++S + E L+LE
Sbjct: 245 TGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVE---ETGVVLSLEQTE 301
Query: 371 SEALHSSALKDKG--SSLEPRQHFNTLDV-GASGLNTSHSPSASSRSSHKSSHTAMSE-- 425
HS +G S + ++LD G L H PS S + S
Sbjct: 302 Q---HSRRPIQRGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDL 358
Query: 426 -----PTSTPTKLMAEASTPAL------PRSATLPQELPV 454
P + A STP P SA LP ELPV
Sbjct: 359 RRLLGPILDGASVAATPSTPLATRHPQSPLSADLPDELPV 398
>gi|21614542 single-minded homolog 1 [Homo sapiens]
Length = 766
Score = 93.2 bits (230), Expect = 9e-19
Identities = 89/359 (24%), Positives = 160/359 (44%), Gaps = 39/359 (10%)
Query: 6 KDRAKRASRNKSEKKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGFLQKHNEV 62
K+++K A+R + EK+ + + EL+ +LP T ++DK +++ +L K V
Sbjct: 2 KEKSKNAARTRREKENSEFY-----ELAKLLPLPSAITSQLDKASIIRLTTSYL-KMRVV 55
Query: 63 SAQTEICDIQQDW----KPSFLSN--EEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPL 116
+ + + W + S L N E +L+ LDGFI V DG I+Y+S++ +
Sbjct: 56 FPE----GLGEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVH 111
Query: 117 LGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEY-LKSDSDLEFYCHLLRG 175
LG ++ ++ ++ +H E+ +L++H EY ++ L C L +
Sbjct: 112 LGLSQVELTGNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKR 171
Query: 176 SLNPKEFPTYEYIKFVG--NFRSYNNVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLA 233
+ Y+ I G R Y+ SP + N V +A
Sbjct: 172 NAG-LTCGGYKVIHCSGYLKIRQYSLDMSPFDGCYQN-------------VGLVAVGHSL 217
Query: 234 TPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDL 293
P + E+ + F R SL+ K +FLD R + GY P +++ + Y + H D
Sbjct: 218 PPSAVTEIKLHSNM---FMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDT 274
Query: 294 ELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVVS 352
L H L+ G+ + YRFL K W+W+Q++ I ++ +S+P IV + V++
Sbjct: 275 FHLRCAHHLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLT 333
>gi|4827004 single-minded homolog 2 long isoform [Homo sapiens]
Length = 667
Score = 91.3 bits (225), Expect = 3e-18
Identities = 100/459 (21%), Positives = 202/459 (44%), Gaps = 58/459 (12%)
Query: 6 KDRAKRASRNKSEKKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGFLQKHNEV 62
K+++K A++ + EK+ + + EL+ +LP T ++DK +++ +L K V
Sbjct: 2 KEKSKNAAKTRREKENGEFY-----ELAKLLPLPSAITSQLDKASIIRLTTSYL-KMRAV 55
Query: 63 SAQTEICDIQQDW-KPSFLSN-----EEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPL 116
+ + W +PS +E +L+ LDGF+ V +DG I+Y+S++ +
Sbjct: 56 FPE----GLGDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVH 111
Query: 117 LGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEY-LKSDSDLEFYCHLLRG 175
LG ++ ++ ++ +H E+ +L++H + EY ++ L C L +
Sbjct: 112 LGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKR 171
Query: 176 SLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLATP 235
+ Y+ I G + + D +L C +G +A + P
Sbjct: 172 NAG-LTCSGYKVIHCSGYLKIRQYM-------LDMSLYDSCYQIVG----LVAVGQSLPP 219
Query: 236 QFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLEL 295
+ E+ + F R SL+ K +FLD R + GY P +++ + Y + H D+
Sbjct: 220 SAITEIKLYSNM---FMFRASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFH 276
Query: 296 LARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSV---VS 352
L H L+ G+ + YR L+K W+W+Q++ + ++ +S+P IV + V +
Sbjct: 277 LRYAHHLLLVKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIE 336
Query: 353 YADVRVERRQELALEDPPS--EALHSS-----ALKDKGSSLE---------PRQH----F 392
Y ++++ Q + S AL +S +K K + ++ P+Q+
Sbjct: 337 YKELQLSLEQVSTAKSQDSWRTALSTSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQM 396
Query: 393 NTLDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPT 431
+ L+ G G + P++++ H+ S+ TP+
Sbjct: 397 DKLECGQLGNWRASPPASAAAPPELQPHSESSDLLYTPS 435
>gi|194239684 single-minded homolog 2 short isoform [Homo sapiens]
Length = 570
Score = 91.3 bits (225), Expect = 3e-18
Identities = 100/459 (21%), Positives = 202/459 (44%), Gaps = 58/459 (12%)
Query: 6 KDRAKRASRNKSEKKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGFLQKHNEV 62
K+++K A++ + EK+ + + EL+ +LP T ++DK +++ +L K V
Sbjct: 2 KEKSKNAAKTRREKENGEFY-----ELAKLLPLPSAITSQLDKASIIRLTTSYL-KMRAV 55
Query: 63 SAQTEICDIQQDW-KPSFLSN-----EEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPL 116
+ + W +PS +E +L+ LDGF+ V +DG I+Y+S++ +
Sbjct: 56 FPE----GLGDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVH 111
Query: 117 LGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEY-LKSDSDLEFYCHLLRG 175
LG ++ ++ ++ +H E+ +L++H + EY ++ L C L +
Sbjct: 112 LGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKR 171
Query: 176 SLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLATP 235
+ Y+ I G + + D +L C +G +A + P
Sbjct: 172 NAG-LTCSGYKVIHCSGYLKIRQYM-------LDMSLYDSCYQIVG----LVAVGQSLPP 219
Query: 236 QFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLEL 295
+ E+ + F R SL+ K +FLD R + GY P +++ + Y + H D+
Sbjct: 220 SAITEIKLYSNM---FMFRASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFH 276
Query: 296 LARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSV---VS 352
L H L+ G+ + YR L+K W+W+Q++ + ++ +S+P IV + V +
Sbjct: 277 LRYAHHLLLVKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIE 336
Query: 353 YADVRVERRQELALEDPPS--EALHSS-----ALKDKGSSLE---------PRQH----F 392
Y ++++ Q + S AL +S +K K + ++ P+Q+
Sbjct: 337 YKELQLSLEQVSTAKSQDSWRTALSTSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQM 396
Query: 393 NTLDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPT 431
+ L+ G G + P++++ H+ S+ TP+
Sbjct: 397 DKLECGQLGNWRASPPASAAAPPELQPHSESSDLLYTPS 435
>gi|4502003 aryl hydrocarbon receptor [Homo sapiens]
Length = 848
Score = 86.3 bits (212), Expect = 1e-16
Identities = 86/359 (23%), Positives = 158/359 (44%), Gaps = 33/359 (9%)
Query: 14 RNKSEKKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGFLQKHNEV-----SAQ 65
++ K+ RD+ N + L+S+LP K+DK +VL + +L+ + S+
Sbjct: 32 KSNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSSP 91
Query: 66 TEICDIQQDWKPSFLS---NEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPLLGHLPS 122
TE Q + + + N + + +L+AL+GF++ VTTD + Y S +I LG S
Sbjct: 92 TERNGGQDNCRAANFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASSTIQDYLGFQQS 151
Query: 123 DVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLLR-------G 175
DV+ Q++ + ++ +E + L H + S E S +E L +
Sbjct: 152 DVIHQSVYELIHTEDRAEFQRQL--HWALNPSQCTE---SGQGIEEATGLPQTVVCYNPD 206
Query: 176 SLNPKEFPTYEYIKFVGNFRS-YNNVPSPSCNGFDNTLS-RPCRVPLGKEVCF----IAT 229
+ P+ P E F+ R +N F L + GK+ +A
Sbjct: 207 QIPPENSPLMERC-FICRLRCLLDNSSGFLAMNFQGKLKYLHGQKKKGKDGSILPPQLAL 265
Query: 230 VRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGT-SGYDYY 288
+ATP + + F ++H L++ + D + ++GY E+ SGY +
Sbjct: 266 FAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTEAELCTRGSGYQFI 325
Query: 289 HIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCT 347
H D+ A H +++ G+ +R LTK +W W+Q++ + Y N +P++I+ T
Sbjct: 326 HAADMLYCAESHIRMIKTGESGMIVFRLLTKNNRWTWVQSNARLLYK--NGRPDYIIVT 382
>gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens]
Length = 901
Score = 80.5 bits (197), Expect = 6e-15
Identities = 94/483 (19%), Positives = 193/483 (39%), Gaps = 85/483 (17%)
Query: 2 DEDEKDRAKRASRNKSE---KKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGF 55
D ++R + + KS + RR + N EL+ +LP T ++DK +++ I +
Sbjct: 11 DPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISY 70
Query: 56 LQKHNEVSA--------------QTEICDIQQDWKPSFLSNEEFTQLM----LEALDGFI 97
L+ + + T + Q+ PS L+ E F + L++LDGF+
Sbjct: 71 LKMRDFANQGDPPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFV 130
Query: 98 IAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKIL------------ 145
A+ +G +Y+S++++ LG ++ ++ +++ +H E+ + L
Sbjct: 131 FALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLS 190
Query: 146 ------------SSHMLVTDSP----SPEYLKSDSDLE--FYCHLLRGSLNPK----EFP 183
SS T P SP L +D+ LE F+ + + +L + +
Sbjct: 191 QGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRM-KSTLTKRGVHIKSS 249
Query: 184 TYEYIKFVGNFRSYNNVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLATPQFLKEMCI 243
Y+ I G R +LS VP + + + P + E+ I
Sbjct: 250 GYKVIHITGRLR------------LRVSLSHGRTVP-SQIMGLVVVAHALPPPTINEVRI 296
Query: 244 VDEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCHQHL 303
F +R +++ ++ ++R + P +++G Y + H +D+E + H L
Sbjct: 297 ---DCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDL 353
Query: 304 MQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVVSYADVRVERRQE 363
+ G+ + YR++ K +IW+Q+ I + N+ + I+ + ++S + +
Sbjct: 354 LNKGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYK------ 407
Query: 364 LALEDPPSEALHSSALKDKGSSLEPRQHFNTLDVGASGLNTSHSPSASSRSSHKSSHTAM 423
D P + L +K S + SG+ + S S ++S ++
Sbjct: 408 ----DTPMDIAQLPHLPEKTSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSED 463
Query: 424 SEP 426
EP
Sbjct: 464 PEP 466
>gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens]
Length = 1399
Score = 79.3 bits (194), Expect = 1e-14
Identities = 83/354 (23%), Positives = 145/354 (40%), Gaps = 36/354 (10%)
Query: 15 NKSEKKRRDQFNVLIKELSSMLPGNTR-------KMDKTTVLEKVIGFLQ--KHNEVSAQ 65
+ +EK+RR+Q N ++EL+ +L N K DK +L+K + +Q K E
Sbjct: 29 SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS 88
Query: 66 TEICDIQQDWKPS----FLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPLLGHLP 121
T D+Q+ S + E L+LEALDGF V +G I++VS+++T LG+
Sbjct: 89 TTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQ 148
Query: 122 SDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLLRGSLNPKE 181
++M+ ++ + L +H+E K L LV P P+ + F C +L ++P +
Sbjct: 149 EELMNTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRML---IHPPD 205
Query: 182 FPTYEYIKFVGNFRSYN--NVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLATPQFLK 239
P E + + V P D + C + + + RL P +
Sbjct: 206 EPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQSCLICIAR--------RLPRPPAI- 256
Query: 240 EMCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFE-VLGTSGYDYYHIDDLE--LL 296
+E F ++ K + +D + G +E ++ Y ++ E
Sbjct: 257 ------TGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYA 310
Query: 297 ARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSV 350
+ Q +M G S YRF+ + T + Y Q FI+ H +
Sbjct: 311 RQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMGIHII 364
>gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens]
Length = 1440
Score = 79.3 bits (194), Expect = 1e-14
Identities = 83/354 (23%), Positives = 145/354 (40%), Gaps = 36/354 (10%)
Query: 15 NKSEKKRRDQFNVLIKELSSMLPGNTR-------KMDKTTVLEKVIGFLQ--KHNEVSAQ 65
+ +EK+RR+Q N ++EL+ +L N K DK +L+K + +Q K E
Sbjct: 29 SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS 88
Query: 66 TEICDIQQDWKPS----FLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPLLGHLP 121
T D+Q+ S + E L+LEALDGF V +G I++VS+++T LG+
Sbjct: 89 TTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQ 148
Query: 122 SDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLLRGSLNPKE 181
++M+ ++ + L +H+E K L LV P P+ + F C +L ++P +
Sbjct: 149 EELMNTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRML---IHPPD 205
Query: 182 FPTYEYIKFVGNFRSYN--NVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLATPQFLK 239
P E + + V P D + C + + + RL P +
Sbjct: 206 EPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQSCLICIAR--------RLPRPPAI- 256
Query: 240 EMCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFE-VLGTSGYDYYHIDDLE--LL 296
+E F ++ K + +D + G +E ++ Y ++ E
Sbjct: 257 ------TGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYA 310
Query: 297 ARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSV 350
+ Q +M G S YRF+ + T + Y Q FI+ H +
Sbjct: 311 RQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMGIHII 364
>gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens]
Length = 1441
Score = 79.3 bits (194), Expect = 1e-14
Identities = 83/354 (23%), Positives = 145/354 (40%), Gaps = 36/354 (10%)
Query: 15 NKSEKKRRDQFNVLIKELSSMLPGNTR-------KMDKTTVLEKVIGFLQ--KHNEVSAQ 65
+ +EK+RR+Q N ++EL+ +L N K DK +L+K + +Q K E
Sbjct: 29 SSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKS 88
Query: 66 TEICDIQQDWKPS----FLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPLLGHLP 121
T D+Q+ S + E L+LEALDGF V +G I++VS+++T LG+
Sbjct: 89 TTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQ 148
Query: 122 SDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLLRGSLNPKE 181
++M+ ++ + L +H+E K L LV P P+ + F C +L ++P +
Sbjct: 149 EELMNTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRML---IHPPD 205
Query: 182 FPTYEYIKFVGNFRSYN--NVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLATPQFLK 239
P E + + V P D + C + + + RL P +
Sbjct: 206 EPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQSCLICIAR--------RLPRPPAI- 256
Query: 240 EMCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFE-VLGTSGYDYYHIDDLE--LL 296
+E F ++ K + +D + G +E ++ Y ++ E
Sbjct: 257 ------TGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYA 310
Query: 297 ARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSV 350
+ Q +M G S YRF+ + T + Y Q FI+ H +
Sbjct: 311 RQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMGIHII 364
>gi|30795240 aryl hydrocarbon receptor nuclear translocator isoform
2 [Homo sapiens]
Length = 328
Score = 76.6 bits (187), Expect = 9e-14
Identities = 47/147 (31%), Positives = 80/147 (54%), Gaps = 8/147 (5%)
Query: 5 EKDRAKRASRNKSEKKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGFLQKHNE 61
+K+R R + ++ E++RR++ I ELS M+P RK DK T+L + H +
Sbjct: 85 DKERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVS----HMK 140
Query: 62 VSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTD-GSIIYVSDSITPLLGHL 120
T +KPSFL+++E L+LEA DGF+ V+ + G ++YVSDS+TP+L
Sbjct: 141 SLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQP 200
Query: 121 PSDVMDQNLLNFLPEQEHSEVYKILSS 147
S+ L + + + ++ + LS+
Sbjct: 201 QSEWFGSTLYDQVHPDDVDKLREQLST 227
>gi|5729858 nuclear receptor coactivator 2 [Homo sapiens]
Length = 1464
Score = 74.7 bits (182), Expect = 3e-13
Identities = 77/359 (21%), Positives = 150/359 (41%), Gaps = 28/359 (7%)
Query: 7 DRAKRASRNKSEKKRRDQFNVLIKELSSMLPGNTR-------KMDKTTVLEKVIGFLQ-- 57
D+ + + +EK+ R+Q N I+EL+ ++ N K DK +L++ + ++
Sbjct: 24 DQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQI 83
Query: 58 KHNEVSAQTEICDIQQDWKPS----FLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSI 113
K E +A I ++Q+ S + + +MLEALDGF V +G++++VS+++
Sbjct: 84 KEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFVVNLEGNVVFVSENV 143
Query: 114 TPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLL 173
T L + ++M++++ + L +H+E K L +V + F C +L
Sbjct: 144 TQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSIVNGGSWSGEPPRRNSHTFNCRML 203
Query: 174 RGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLA 233
L E ++ N ++ + C +S+P + E + +A
Sbjct: 204 VKPLPDSEEEGHD------NQEAHQKYETMQC----FAVSQPKSIKEEGEDLQSCLICVA 253
Query: 234 TPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHI--- 290
+KE ++ E FT+R L+ K LD +E L +H
Sbjct: 254 RRVPMKERPVLPSS-ESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLVRRCIQKFHAQHE 312
Query: 291 -DDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTH 348
+ + R H +++ G S YRF + QT + Q ++P+ ++ H
Sbjct: 313 GESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQTTNEPQLVISLH 371
>gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens]
Length = 920
Score = 74.3 bits (181), Expect = 4e-13
Identities = 95/502 (18%), Positives = 196/502 (39%), Gaps = 104/502 (20%)
Query: 2 DEDEKDRAKRASRNKSE---KKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGF 55
D ++R + + KS + RR + N EL+ +LP T ++DK +++ I +
Sbjct: 11 DPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISY 70
Query: 56 LQKHN------------------------------EVSAQTEICDI---QQDWKPSFLSN 82
L+ + E+ + C++ Q+ PS L+
Sbjct: 71 LKMRDFANQGDPPWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAI 130
Query: 83 EEFTQLM----LEALDGFIIAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEH 138
E F + L++LDGF+ A+ +G +Y+S++++ LG ++ ++ +++ +H
Sbjct: 131 EVFEAHLGSHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDH 190
Query: 139 SEVYKIL------------------------SSHMLVTDSP----SPEYLKSDSDLE--F 168
E+ + L SS T P SP L +D+ LE F
Sbjct: 191 VEMAEQLGMKLPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSF 250
Query: 169 YCHLLRGSLNPK----EFPTYEYIKFVGNFRSYNNVPSPSCNGFDNTLSRPCRVPLGKEV 224
+ + + +L + + Y+ I G R +LS VP + +
Sbjct: 251 FIRM-KSTLTKRGVHIKSSGYKVIHITGRLR------------LRVSLSHGRTVP-SQIM 296
Query: 225 CFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSG 284
+ P + E+ I F +R +++ ++ ++R + P +++G
Sbjct: 297 GLVVVAHALPPPTINEVRI---DCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRC 353
Query: 285 YDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFI 344
Y + H +D+E + H L+ G+ + YR++ K +IW+Q+ I + N+ + I
Sbjct: 354 YHFIHAEDVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNI 413
Query: 345 VCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQHFNTLDVGASGLNT 404
+ + ++S + + D P + L +K S + SG+
Sbjct: 414 IWVNYLLSNPEYK----------DTPMDIAQLPHLPEKTSESSETSDSESDSKDTSGITE 463
Query: 405 SHSPSASSRSSHKSSHTAMSEP 426
+ S S ++S ++ EP
Sbjct: 464 DNENSKSDEKGNQSENSEDPEP 485
>gi|12707562 period 2 [Homo sapiens]
Length = 1255
Score = 67.0 bits (162), Expect = 7e-11
Identities = 98/422 (23%), Positives = 160/422 (37%), Gaps = 63/422 (14%)
Query: 29 IKELSSMLPGNTRKMDKTTVLEKVIGFLQKHNEVSAQTEICDIQQDWK--------PSFL 80
+KEL LP + + K + L + L+ +V A E + + PS+
Sbjct: 115 LKELKVHLPADKKAKGKASTLATLKYALRSVKQVKANEEYYQLLMSSEGHPCGADVPSYT 174
Query: 81 SNEE---FTQLMLEALDGFIIAVT-TDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQ 136
E ++ +++ D F +AV+ G I+Y+SD + + D + FL
Sbjct: 175 VEEMESVTSEHIVKNADMFAVAVSLVSGKILYISDQVASIFHCKRDAFSDAKFVEFLAPH 234
Query: 137 EHSEVYKILSSHMLV-------TDSPSPEYLKSDSDLEFYCHLL--RGSLNPKEFPTYEY 187
+ + S + L DS + E ++ S F+C + + N + +
Sbjct: 235 DVGVFHSFTSPYKLPLWSMCSGADSFTQECMEEKS---FFCRVSVRKSHENEIRYHPFRM 291
Query: 188 IKFVGNFRSYNNVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLATPQFLKEMCIVDEP 247
++ R S C L RV G E P+ E I
Sbjct: 292 TPYLVKVRDQQGAESQLC-----CLLLAERVHSGYEA----------PRIPPEKRI---- 332
Query: 248 LEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQFG 307
FT+ H+ F +D RA P++GYLP +++ T H D L+ H+ ++Q G
Sbjct: 333 ---FTTTHTPNCLFQDVDERAVPLLGYLPQDLIETPVLVQLHPSDRPLMLAIHKKILQSG 389
Query: 308 KGKSCCY---RFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVVSYADVRVERRQEL 364
G+ Y RF + ++I L T + + W+ K FI+ H VRV E
Sbjct: 390 -GQPFDYSPIRFRARNGEYITLDTSWSSFINPWSRKISFIIGRHK------VRVGPLNED 442
Query: 365 ALEDPP---SEALHSSALKDKGS----SLEPRQHFNTLDVGASGLNTSHSPSASSRSSHK 417
P +ALH S + L+P H + G+ G N SH S SS
Sbjct: 443 VFAAHPCTEEKALHPSIQELTEQIHRLLLQPVPHSGSSGYGSLGSNGSHEHLMSQTSSSD 502
Query: 418 SS 419
S+
Sbjct: 503 SN 504
Score = 30.4 bits (67), Expect = 7.0
Identities = 30/104 (28%), Positives = 44/104 (42%), Gaps = 6/104 (5%)
Query: 401 GLN-TSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEAST----PALPRSATLPQELPVP 455
GLN T+ SPS +S+SS + P + + T PA P ++ +PV
Sbjct: 825 GLNATAWSPSDTSQSSCPAVPFPAPVPAAYSLPVFPAPGTVAAPPAPPHASFTVPAVPVD 884
Query: 456 GLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTP-APMAQFSAQ 498
Q A P P P+P + + L + TP P A F +Q
Sbjct: 885 LQHQFAVQPPPFPAPLAPVMAFMLPSYSFPSGTPNLPQAFFPSQ 928
>gi|8567388 period 3 [Homo sapiens]
Length = 1201
Score = 62.8 bits (151), Expect = 1e-09
Identities = 132/646 (20%), Positives = 242/646 (37%), Gaps = 99/646 (15%)
Query: 215 PCRVPLGKEVCFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGY 274
P + L E C + V + V++ + FT+ H+ FL +D +A P++GY
Sbjct: 240 PAQPELESEPCCLTVVEKIHSGYEAPRIPVNKRI--FTTTHTPGCVFLEVDEKAVPLLGY 297
Query: 275 LPFEVLGTSGYDYYHIDDLELLARCHQHLMQFG---KGKSCCYRFLTKGQQWIWLQTHYY 331
LP +++GTS Y H +D L+ HQ ++++ + RF T+ +I L + +
Sbjct: 298 LPQDLIGTSILSYLHPEDRSLMVAIHQKVLKYAGHPPFEHSPIRFCTQNGDYIILDSSWS 357
Query: 332 ITYHQWNSKPEFIVCTHSVVS---YADVRVERRQELALEDPPSEALHSSALKDKGSSLEP 388
+ W+ K FI+ H V + DV + +++ D L K L+P
Sbjct: 358 SFVNPWSRKISFIIGRHKVRTSPLNEDVFATKIKKMNDNDKDITELQEQIYK---LLLQP 414
Query: 389 RQHFNTLDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPALPRSATL 448
+ G+ G + S S SS ++S + E + ++ + ++ + L
Sbjct: 415 VHVSVSSGYGSLGSSGSQEQLVSIASSSEASGHRVEE--TKAEQMTLQQVYASVNKIKNL 472
Query: 449 PQELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSAQFSMFQTIKDQ 508
Q+L + +++++ P T ++ P + S QT+K+
Sbjct: 473 GQQLYIESMTKSSFKPV-----------------TGTRTEPNGGGECKTFTSFHQTLKNN 515
Query: 509 ---LEQRTRILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRPEAQQ 565
E + ++++ I + ++ N+ ++ +S ++T +++
Sbjct: 516 SVYTEPCEDLRNDEHSPSYQQINCIDSVIRYLKSYNIPALKRK---CISCTNTTSSSSEE 572
Query: 566 QLQQRSAAVTQPQLGAGPQLPGQISSAQVTSQHLLRESSVISTQGPKPMRSSQLMQSSGR 625
Q A Q L AG Q+P S T+ I T G P S M S G
Sbjct: 573 DKQNHKADDVQ-ALQAGLQIPAIPKSEMPTN------GRSIDTGGGAPQILSTAMLSLG- 624
Query: 626 SGSSLVSPFSSATAALPP--------------SLNLTTPASTSQD-----------ASQC 660
SG S +SS +PP +LN+ TS++ ++
Sbjct: 625 SGISQCG-YSSTIVHVPPPETARDATLFCEPWTLNMQPAPLTSEEFKHVGLTAAVLSAHT 683
Query: 661 QPSPDFSHDRQLRLLLSQPIQPMMPGSCDARQPSEVS-----RTGRQVKYA-------QS 708
Q D+ +LS P + ++R ++ S T +Q + A +
Sbjct: 684 QKEEQNYVDKFREKILSSPYSSYL--QQESRSKAKYSYFQGDSTSKQTRSAGCRKGKHKR 741
Query: 709 QTVFQNPDAHPANSSSAP--------MPVLLMGQAVLHPSFPASQPSPLQPAQARQQPPQ 760
+ + + PD+ +N+ S P P + H S P P+ + P+QA P
Sbjct: 742 KKLPEPPDSSSSNTGSGPRRGAHQNAQPCCPSAASSPHTSSPTFPPAAMVPSQAPYLVPA 801
Query: 761 HYLQVQAPTSLHSEQQDSLLLSTYSQQPGTLGYPQPPPAQPQPLRP 806
+ A TS E + + G G P QP P P
Sbjct: 802 --FPLPAATSPGRE-----YAAPGTAPEGLHGLPLSEGLQPYPAFP 840
>gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens]
Length = 1424
Score = 60.8 bits (146), Expect = 5e-09
Identities = 38/140 (27%), Positives = 72/140 (51%), Gaps = 12/140 (8%)
Query: 18 EKKRRDQFNVLIKELSSMLPGNTR-------KMDKTTVLEKVIGFLQKHNEVSAQTEICD 70
EK+RR+Q + I+EL+ ++ N K DK +L++ + +++ E D
Sbjct: 34 EKRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTISNDD 93
Query: 71 IQQDWKPS-----FLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPLLGHLPSDVM 125
Q S + + L+L+ALDGF+ V DG+I++VS+++T L + D++
Sbjct: 94 DVQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLV 153
Query: 126 DQNLLNFLPEQEHSEVYKIL 145
+ ++ N L E++ + K L
Sbjct: 154 NTSVYNILHEEDRKDFLKNL 173
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.128 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,823,171
Number of Sequences: 37866
Number of extensions: 1935090
Number of successful extensions: 17378
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 115
Number of HSP's successfully gapped in prelim test: 727
Number of HSP's that attempted gapping in prelim test: 12736
Number of HSP's gapped (non-prelim): 4075
length of query: 824
length of database: 18,247,518
effective HSP length: 111
effective length of query: 713
effective length of database: 14,044,392
effective search space: 10013651496
effective search space used: 10013651496
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.