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Search of human proteins with 21614542
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21614542 single-minded homolog 1 [Homo sapiens]
(766 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21614542 single-minded homolog 1 [Homo sapiens] 1577 0.0
gi|4827004 single-minded homolog 2 long isoform [Homo sapiens] 676 0.0
gi|194239684 single-minded homolog 2 short isoform [Homo sapiens] 676 0.0
gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens] 298 2e-80
gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens] 291 2e-78
gi|22027482 neuronal PAS domain protein 1 [Homo sapiens] 276 5e-74
gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2 ... 269 6e-72
gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1 [... 269 6e-72
gi|40254439 endothelial PAS domain protein 1 [Homo sapiens] 243 6e-64
gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a ... 228 1e-59
gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c ... 228 1e-59
gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b ... 187 2e-47
gi|71852582 aryl hydrocarbon receptor nuclear translocator-like ... 130 6e-30
gi|71852580 aryl hydrocarbon receptor nuclear translocator-like ... 130 6e-30
gi|42716311 aryl hydrocarbon receptor nuclear translocator-like ... 130 6e-30
gi|4502003 aryl hydrocarbon receptor [Homo sapiens] 122 2e-27
gi|31745180 aryl hydrocarbon receptor nuclear translocator-like ... 119 1e-26
gi|4758010 clock [Homo sapiens] 113 6e-25
gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Ho... 113 8e-25
gi|30795242 aryl hydrocarbon receptor nuclear translocator isofo... 106 9e-23
gi|4502231 aryl hydrocarbon receptor nuclear translocator isofor... 106 9e-23
gi|194097477 neuronal PAS domain protein 4 [Homo sapiens] 96 1e-19
gi|22027471 neuronal PAS domain protein 2 [Homo sapiens] 93 8e-19
gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens] 92 2e-18
gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens] 92 2e-18
gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens] 92 2e-18
gi|115430245 arylhydrocarbon receptor repressor [Homo sapiens] 79 2e-14
gi|5729858 nuclear receptor coactivator 2 [Homo sapiens] 75 2e-13
gi|30795240 aryl hydrocarbon receptor nuclear translocator isofo... 69 2e-11
gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens] 64 5e-10
>gi|21614542 single-minded homolog 1 [Homo sapiens]
Length = 766
Score = 1577 bits (4084), Expect = 0.0
Identities = 766/766 (100%), Positives = 766/766 (100%)
Query: 1 MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGL 60
MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGL
Sbjct: 1 MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGL 60
Query: 61 GEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELT 120
GEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELT
Sbjct: 61 GEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELT 120
Query: 121 GNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGY 180
GNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGY
Sbjct: 121 GNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGY 180
Query: 181 KVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDM 240
KVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDM
Sbjct: 181 KVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDM 240
Query: 241 KLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYRFLAK 300
KLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYRFLAK
Sbjct: 241 KLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYRFLAK 300
Query: 301 HGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQISASKPAFSYTSSS 360
HGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQISASKPAFSYTSSS
Sbjct: 301 HGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQISASKPAFSYTSSS 360
Query: 361 TPTMTDNRKGAKSRLSSSKSKSRTSPYPQYSGFHTERSESDHDSQWGGSPLTDTASPQLL 420
TPTMTDNRKGAKSRLSSSKSKSRTSPYPQYSGFHTERSESDHDSQWGGSPLTDTASPQLL
Sbjct: 361 TPTMTDNRKGAKSRLSSSKSKSRTSPYPQYSGFHTERSESDHDSQWGGSPLTDTASPQLL 420
Query: 421 DPADRPGSQHDASCAYRQFSDRSSLCYGFALDHSRLVEERHFHTQACEGGRCEAGRYFLG 480
DPADRPGSQHDASCAYRQFSDRSSLCYGFALDHSRLVEERHFHTQACEGGRCEAGRYFLG
Sbjct: 421 DPADRPGSQHDASCAYRQFSDRSSLCYGFALDHSRLVEERHFHTQACEGGRCEAGRYFLG 480
Query: 481 TPQAGREPWWGSRAALPLTKASPESREAYENSMPHIASVHRIHGRGHWDEDSVVSSPDPG 540
TPQAGREPWWGSRAALPLTKASPESREAYENSMPHIASVHRIHGRGHWDEDSVVSSPDPG
Sbjct: 481 TPQAGREPWWGSRAALPLTKASPESREAYENSMPHIASVHRIHGRGHWDEDSVVSSPDPG 540
Query: 541 SASESGDRYRTEQYQSSPHEPSKIETLIRATQQMIKEEENRLQLRKAPSDQLASINGAGK 600
SASESGDRYRTEQYQSSPHEPSKIETLIRATQQMIKEEENRLQLRKAPSDQLASINGAGK
Sbjct: 541 SASESGDRYRTEQYQSSPHEPSKIETLIRATQQMIKEEENRLQLRKAPSDQLASINGAGK 600
Query: 601 KHSLCFANYQQPPPTGEVCHGSALANTSPCDHIQQREGKMLSPHENDYDNSPTALSRISS 660
KHSLCFANYQQPPPTGEVCHGSALANTSPCDHIQQREGKMLSPHENDYDNSPTALSRISS
Sbjct: 601 KHSLCFANYQQPPPTGEVCHGSALANTSPCDHIQQREGKMLSPHENDYDNSPTALSRISS 660
Query: 661 PNSDRISKSSLILAKDYLHSDISPHQTAGDHPTVSPNCFGSHRQYFDKHAYTLTGYALEH 720
PNSDRISKSSLILAKDYLHSDISPHQTAGDHPTVSPNCFGSHRQYFDKHAYTLTGYALEH
Sbjct: 661 PNSDRISKSSLILAKDYLHSDISPHQTAGDHPTVSPNCFGSHRQYFDKHAYTLTGYALEH 720
Query: 721 LYDSETIRNYSLGCNGSHFDVTSHLRMQPDPAQGHKGTSVIITNGS 766
LYDSETIRNYSLGCNGSHFDVTSHLRMQPDPAQGHKGTSVIITNGS
Sbjct: 721 LYDSETIRNYSLGCNGSHFDVTSHLRMQPDPAQGHKGTSVIITNGS 766
>gi|4827004 single-minded homolog 2 long isoform [Homo sapiens]
Length = 667
Score = 676 bits (1743), Expect = 0.0
Identities = 353/509 (69%), Positives = 391/509 (76%), Gaps = 11/509 (2%)
Query: 1 MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGL 60
MKEKSKNAA+TRREKEN EFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMR VFPEGL
Sbjct: 1 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGL 60
Query: 61 GEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELT 120
G+AWG SR PLD V +ELGSHLLQTLDGF+FVVA DGKIMYISETASVHLGLSQVELT
Sbjct: 61 GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT 120
Query: 121 GNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGY 180
GNSIYEYIHP+DHDEMTAVLTAHQP H H +QEYEIERSFFLRMKCVLAKRNAGLTC GY
Sbjct: 121 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGY 180
Query: 181 KVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDM 240
KVIHCSGYLKIRQY LDMS +D CYQ VGLVAVG SLPPSA+TEIKL+SNMFMFRASLD+
Sbjct: 181 KVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDL 240
Query: 241 KLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYRFLAK 300
KLIFLDSRV E+TGYEPQDLIEKTLYHHVHGCD FHLR AHHLLLVKGQVTTKYYR L+K
Sbjct: 241 KLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSK 300
Query: 301 HGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQISASKPAFSYTSSS 360
GGWVWVQSYAT+VHNSRSSRPHCIVSVNYVLT+ EYK LQLSL+Q+S +K S+ ++
Sbjct: 301 RGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTAL 360
Query: 361 TPTMTDNRKGAKSRLSSSKSKSRTSPYP--QYSGFHTERSESDHDSQWGGSPLTDTASPQ 418
+ T + RK K + + K+K RT+PYP QYS F ++ E W SP A+P
Sbjct: 361 S-TSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRASPPASAAAP- 418
Query: 419 LLDPADRPGSQHDASCAYRQFSDRSSLCYG-FALDHSRLVEERHFHTQAC---EGGRCEA 474
P +P S+ +S S YG F LD ++ +G CE
Sbjct: 419 ---PELQPHSESSDLLYTPSYSLPFSYHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEV 475
Query: 475 GRYFLGTPQAGREPWWGSRAALPLTKASP 503
R+FL T A E W L + +SP
Sbjct: 476 ARFFLSTLPASGECQWHYANPLVPSSSSP 504
>gi|194239684 single-minded homolog 2 short isoform [Homo sapiens]
Length = 570
Score = 676 bits (1743), Expect = 0.0
Identities = 353/509 (69%), Positives = 391/509 (76%), Gaps = 11/509 (2%)
Query: 1 MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGL 60
MKEKSKNAA+TRREKEN EFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMR VFPEGL
Sbjct: 1 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGL 60
Query: 61 GEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELT 120
G+AWG SR PLD V +ELGSHLLQTLDGF+FVVA DGKIMYISETASVHLGLSQVELT
Sbjct: 61 GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT 120
Query: 121 GNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGY 180
GNSIYEYIHP+DHDEMTAVLTAHQP H H +QEYEIERSFFLRMKCVLAKRNAGLTC GY
Sbjct: 121 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGY 180
Query: 181 KVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDM 240
KVIHCSGYLKIRQY LDMS +D CYQ VGLVAVG SLPPSA+TEIKL+SNMFMFRASLD+
Sbjct: 181 KVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDL 240
Query: 241 KLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYRFLAK 300
KLIFLDSRV E+TGYEPQDLIEKTLYHHVHGCD FHLR AHHLLLVKGQVTTKYYR L+K
Sbjct: 241 KLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSK 300
Query: 301 HGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQISASKPAFSYTSSS 360
GGWVWVQSYAT+VHNSRSSRPHCIVSVNYVLT+ EYK LQLSL+Q+S +K S+ ++
Sbjct: 301 RGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTAL 360
Query: 361 TPTMTDNRKGAKSRLSSSKSKSRTSPYP--QYSGFHTERSESDHDSQWGGSPLTDTASPQ 418
+ T + RK K + + K+K RT+PYP QYS F ++ E W SP A+P
Sbjct: 361 S-TSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRASPPASAAAP- 418
Query: 419 LLDPADRPGSQHDASCAYRQFSDRSSLCYG-FALDHSRLVEERHFHTQAC---EGGRCEA 474
P +P S+ +S S YG F LD ++ +G CE
Sbjct: 419 ---PELQPHSESSDLLYTPSYSLPFSYHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEV 475
Query: 475 GRYFLGTPQAGREPWWGSRAALPLTKASP 503
R+FL T A E W L + +SP
Sbjct: 476 ARFFLSTLPASGECQWHYANPLVPSSSSP 504
>gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens]
Length = 901
Score = 298 bits (762), Expect = 2e-80
Identities = 174/447 (38%), Positives = 251/447 (56%), Gaps = 63/447 (14%)
Query: 2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLG 61
KEKS++AAR+RR KEN EFYELAKLLPLP+AITSQLDKASIIRLT SYLKMR +G
Sbjct: 23 KEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQG-D 81
Query: 62 EAW--------------GHSSRTSP----LDNVGRELGSHLLQTLDGFIFVVAPDGKIMY 103
W G R SP ++ LGSH+LQ+LDGF+F + +GK +Y
Sbjct: 82 PPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLY 141
Query: 104 ISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLTAHQP------------------ 145
ISET S++LGLSQVELTG+S+++Y+HP DH EM L P
Sbjct: 142 ISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASSA 201
Query: 146 ---------------YHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLK 190
S + +ERSFF+RMK L KR + GYKVIH +G L+
Sbjct: 202 SSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRGVHIKSSGYKVIHITGRLR 261
Query: 191 IRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVA 250
+R Q +GLV V H+LPP + E+++ +MF+ R ++D+ +I+ ++R++
Sbjct: 262 LRVSLSHGRTVPS--QIMGLVVVAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCENRIS 319
Query: 251 ELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYRFLAKHGGWVWVQSY 310
+ P D++ K YH +H D +R +H LL KGQ TKYYR++ K+GG++W+QS
Sbjct: 320 DYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGYIWIQSS 379
Query: 311 ATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQI---------SASKPAFSYTSSST 361
ATI N++++ I+ VNY+L++ EYK + + Q+ S+ S T
Sbjct: 380 ATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHLPEKTSESSETSDSESDSKDT 439
Query: 362 PTMTDNRKGAKSRLSSSKSKSRTSPYP 388
+T++ + +KS ++S++ P P
Sbjct: 440 SGITEDNENSKSDEKGNQSENSEDPEP 466
>gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens]
Length = 920
Score = 291 bits (744), Expect = 2e-78
Identities = 174/465 (37%), Positives = 251/465 (53%), Gaps = 80/465 (17%)
Query: 2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLG 61
KEKS++AAR+RR KEN EFYELAKLLPLP+AITSQLDKASIIRLT SYLKMR +G
Sbjct: 23 KEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDP 82
Query: 62 --------------------------------EAWGHSSRTSP----LDNVGRELGSHLL 85
E G R SP ++ LGSH+L
Sbjct: 83 PWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHLGSHIL 142
Query: 86 QTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLTAHQP 145
Q+LDGF+F + +GK +YISET S++LGLSQVELTG+S+++Y+HP DH EM L P
Sbjct: 143 QSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLP 202
Query: 146 ---------------------------------YHSHFVQEYEIERSFFLRMKCVLAKRN 172
S + +ERSFF+RMK L KR
Sbjct: 203 PGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRG 262
Query: 173 AGLTCGGYKVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIKLHSNMF 232
+ GYKVIH +G L++R Q +GLV V H+LPP + E+++ +MF
Sbjct: 263 VHIKSSGYKVIHITGRLRLRVSLSHGRTVPS--QIMGLVVVAHALPPPTINEVRIDCHMF 320
Query: 233 MFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTT 292
+ R ++D+ +I+ ++R+++ P D++ K YH +H D +R +H LL KGQ T
Sbjct: 321 VTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCVT 380
Query: 293 KYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQI----- 347
KYYR++ K+GG++W+QS ATI N++++ I+ VNY+L++ EYK + + Q+
Sbjct: 381 KYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHLPE 440
Query: 348 ----SASKPAFSYTSSSTPTMTDNRKGAKSRLSSSKSKSRTSPYP 388
S+ S T +T++ + +KS ++S++ P P
Sbjct: 441 KTSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEP 485
>gi|22027482 neuronal PAS domain protein 1 [Homo sapiens]
Length = 590
Score = 276 bits (706), Expect = 5e-74
Identities = 177/464 (38%), Positives = 248/464 (53%), Gaps = 74/464 (15%)
Query: 2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLG 61
KEKS+NAAR+RR KEN EF+ELAKLLPLP AI+SQLDKASI+RL+ +YL++R G
Sbjct: 47 KEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALG-A 105
Query: 62 EAWGHSSRTSPL--------------DNVGRELGSHLLQTLDGFIFVVAPDGKIMYISET 107
WG + P + + LG H+LQ+LDGF+F + +GK +YISET
Sbjct: 106 PPWGLRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISET 165
Query: 108 ASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLTAHQP---------------YHSHFVQ 152
S++LGLSQVE+TG+S+++YIHP DH E+ L P S
Sbjct: 166 VSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLAD 225
Query: 153 EYEI--------------ERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLKIRQYSLDM 198
EI ERSFF+RMK L KR + GYKVIH +G ++R ++L
Sbjct: 226 TPEIEASLTKVPPSSLVQERSFFVRMKSTLTKRGLHVKASGYKVIHVTG--RLRAHAL-- 281
Query: 199 SPFDGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQ 258
GLVA+GH+LPP+ + E+ LH +M +FR SL + ++ +SRV++ P
Sbjct: 282 ----------GLVALGHTLPPAPLAELPLHGHMIVFRLSLGLTILACESRVSDHMDLGPS 331
Query: 259 DLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSR 318
+L+ ++ Y VHG D +R +H LL KGQV T YYR+L + GG+VW+QS AT+ + +
Sbjct: 332 ELVGRSCYQFVHGQDATRIRQSHVDLLDKGQVMTGYYRWLQRAGGFVWLQSVATVAGSGK 391
Query: 319 SSRPHCIVSVNYVLTDTEYKGLQLSLDQI---------SASKPAFSYTSSSTPTMTDNRK 369
S H ++ V++VL+ E G Q LD AS P T PT
Sbjct: 392 SPGEHHVLWVSHVLSQAE--GGQTPLDAFQLPASVACEEASSPGPEPTEPEPPTEGKQAA 449
Query: 370 GAKSRLSSSKSKS-RTSPYPQYSGFHTERSESDHDSQWGGSPLT 412
A++ ++ K + P P+ T+ SE D P T
Sbjct: 450 PAENEAPQTQGKRIKVEPGPR----ETKGSEDSGDEDPSSHPAT 489
>gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2
[Homo sapiens]
Length = 735
Score = 269 bits (688), Expect = 6e-72
Identities = 149/370 (40%), Positives = 221/370 (59%), Gaps = 18/370 (4%)
Query: 2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLG 61
KEKS++AAR+RR KE+ FYELA LPLP ++S LDKAS++RLT SYL++R + G
Sbjct: 19 KEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAG-- 76
Query: 62 EAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTG 121
D++ ++ L+ LDGF+ V+ DG ++YIS+ + ++GL+Q ELTG
Sbjct: 77 -------DLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTG 129
Query: 122 NSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNA--GLTCGG 179
+S++++ HP DH+EM +LT H+ +E +RSFFLRMKC L R +
Sbjct: 130 HSVFDFTHPCDHEEMREMLT-HRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSAT 188
Query: 180 YKVIHCSGYLKIRQYSLDMSPFDGCYQN---VGLVAVGHSLPPSAVTEIKLHSNMFMFRA 236
+KV+HC+G++ + Y + + Y+ LV + +P + EI L S F+ R
Sbjct: 189 WKVLHCTGHIHV--YDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRH 246
Query: 237 SLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYR 296
SLDMK + D R+ EL GYEP++L+ +++Y + H D+ HL HH + KGQVTT YR
Sbjct: 247 SLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYR 306
Query: 297 FLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQIS-ASKPAFS 355
LAK GG+VWV++ AT+++N+++S+P CIV VNYV++ L SL Q KP S
Sbjct: 307 MLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVES 366
Query: 356 YTSSSTPTMT 365
T T
Sbjct: 367 SDMKMTQLFT 376
>gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1
[Homo sapiens]
Length = 826
Score = 269 bits (688), Expect = 6e-72
Identities = 149/370 (40%), Positives = 221/370 (59%), Gaps = 18/370 (4%)
Query: 2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLG 61
KEKS++AAR+RR KE+ FYELA LPLP ++S LDKAS++RLT SYL++R + G
Sbjct: 19 KEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAG-- 76
Query: 62 EAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTG 121
D++ ++ L+ LDGF+ V+ DG ++YIS+ + ++GL+Q ELTG
Sbjct: 77 -------DLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTG 129
Query: 122 NSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNA--GLTCGG 179
+S++++ HP DH+EM +LT H+ +E +RSFFLRMKC L R +
Sbjct: 130 HSVFDFTHPCDHEEMREMLT-HRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSAT 188
Query: 180 YKVIHCSGYLKIRQYSLDMSPFDGCYQN---VGLVAVGHSLPPSAVTEIKLHSNMFMFRA 236
+KV+HC+G++ + Y + + Y+ LV + +P + EI L S F+ R
Sbjct: 189 WKVLHCTGHIHV--YDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRH 246
Query: 237 SLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYR 296
SLDMK + D R+ EL GYEP++L+ +++Y + H D+ HL HH + KGQVTT YR
Sbjct: 247 SLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYR 306
Query: 297 FLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQIS-ASKPAFS 355
LAK GG+VWV++ AT+++N+++S+P CIV VNYV++ L SL Q KP S
Sbjct: 307 MLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVES 366
Query: 356 YTSSSTPTMT 365
T T
Sbjct: 367 SDMKMTQLFT 376
>gi|40254439 endothelial PAS domain protein 1 [Homo sapiens]
Length = 870
Score = 243 bits (619), Expect = 6e-64
Identities = 139/382 (36%), Positives = 215/382 (56%), Gaps = 16/382 (4%)
Query: 2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLG 61
KEKS++AAR RR KE FYELA LPLP +++S LDKASI+RL S+L+ +
Sbjct: 16 KEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSVCS 75
Query: 62 EAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTG 121
E + +DN+ L+ L+GFI VV DG ++++SE S +GL+QVELTG
Sbjct: 76 ENESEAEADQQMDNL-------YLKALEGFIAVVTQDGDMIFLSENISKFMGLTQVELTG 128
Query: 122 NSIYEYIHPADHDEMTAVLTAHQPY-HSHFVQEYEIERSFFLRMKCVLAKRN--AGLTCG 178
+SI+++ HP DH+E+ L+ ++ ER FF+RMKC + R L
Sbjct: 129 HSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRGRTVNLKSA 188
Query: 179 GYKVIHCSGYLKIRQYSLDMSPFDGCYQNV--GLVAVGHSLPPSAVTEIKLHSNMFMFRA 236
+KV+HC+G +K+ + G + + L+ + + + +I L S F+ R
Sbjct: 189 TWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLDSKTFLSRH 248
Query: 237 SLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYR 296
S+DMK + D R+ EL GY P++L+ ++ Y H D+ ++ +H L KGQV + YR
Sbjct: 249 SMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKGQVVSGQYR 308
Query: 297 FLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQI-SASKPAFS 355
LAKHGG+VW+++ T+++N R+ +P CI+ VNYVL++ E + S+DQ S KP
Sbjct: 309 MLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTESLFKP--- 365
Query: 356 YTSSSTPTMTDNRKGAKSRLSS 377
+ + + KGA S S+
Sbjct: 366 HLMAMNSIFDSSGKGAVSEKSN 387
>gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a
[Homo sapiens]
Length = 667
Score = 228 bits (582), Expect = 1e-59
Identities = 135/350 (38%), Positives = 194/350 (55%), Gaps = 15/350 (4%)
Query: 2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLG 61
KEKS++AAR+RR +E Y+LA LP +++ LDKASI+RLT SYL+M + G
Sbjct: 14 KEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAGEW 73
Query: 62 EAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTG 121
G G L + L+ L+GF+ V+ +G + Y+SE S HLGLSQ+EL G
Sbjct: 74 NQVGAG---------GEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIG 124
Query: 122 NSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNA--GLTCGG 179
+SI+++IHP D +E+ LT Q V E ER F LRMK L R L
Sbjct: 125 HSIFDFIHPCDQEELQDALTPQQTLSRRKV-EAPTERCFSLRMKSTLTSRGRTLNLKAAT 183
Query: 180 YKVIHCSGYLKIRQYSLDMSPF---DGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRA 236
+KV++CSG+++ + SP D LV + ++P E L F+ R
Sbjct: 184 WKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRH 243
Query: 237 SLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYR 296
SLDMK + D R+AE+ GY P DLI + Y ++H D+ + + H LL KGQ T YR
Sbjct: 244 SLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYR 303
Query: 297 FLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQ 346
FLA+ GG++W Q+ AT+V R + IV V+++++ E G+ LSL+Q
Sbjct: 304 FLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQ 353
>gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c
[Homo sapiens]
Length = 669
Score = 228 bits (582), Expect = 1e-59
Identities = 135/350 (38%), Positives = 194/350 (55%), Gaps = 15/350 (4%)
Query: 2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLG 61
KEKS++AAR+RR +E Y+LA LP +++ LDKASI+RLT SYL+M + G
Sbjct: 16 KEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAGEW 75
Query: 62 EAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTG 121
G G L + L+ L+GF+ V+ +G + Y+SE S HLGLSQ+EL G
Sbjct: 76 NQVGAG---------GEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIG 126
Query: 122 NSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNA--GLTCGG 179
+SI+++IHP D +E+ LT Q V E ER F LRMK L R L
Sbjct: 127 HSIFDFIHPCDQEELQDALTPQQTLSRRKV-EAPTERCFSLRMKSTLTSRGRTLNLKAAT 185
Query: 180 YKVIHCSGYLKIRQYSLDMSPF---DGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRA 236
+KV++CSG+++ + SP D LV + ++P E L F+ R
Sbjct: 186 WKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRH 245
Query: 237 SLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYR 296
SLDMK + D R+AE+ GY P DLI + Y ++H D+ + + H LL KGQ T YR
Sbjct: 246 SLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYR 305
Query: 297 FLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQ 346
FLA+ GG++W Q+ AT+V R + IV V+++++ E G+ LSL+Q
Sbjct: 306 FLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQ 355
>gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b
[Homo sapiens]
Length = 613
Score = 187 bits (476), Expect = 2e-47
Identities = 114/309 (36%), Positives = 165/309 (53%), Gaps = 15/309 (4%)
Query: 43 IRLTTSYLKMRVVFPEGLGEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIM 102
+RLT SYL+M + G G G L + L+ L+GF+ V+ +G +
Sbjct: 1 MRLTISYLRMHRLCAAGEWNQVGAG---------GEPLDACYLKALEGFVMVLTAEGDMA 51
Query: 103 YISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFL 162
Y+SE S HLGLSQ+EL G+SI+++IHP D +E+ LT Q V E ER F L
Sbjct: 52 YLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKV-EAPTERCFSL 110
Query: 163 RMKCVLAKRNA--GLTCGGYKVIHCSGYLKIRQYSLDMSPF---DGCYQNVGLVAVGHSL 217
RMK L R L +KV++CSG+++ + SP D LV + ++
Sbjct: 111 RMKSTLTSRGRTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAI 170
Query: 218 PPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHL 277
P E L F+ R SLDMK + D R+AE+ GY P DLI + Y ++H D+ +
Sbjct: 171 PHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAV 230
Query: 278 RCAHHLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEY 337
+ H LL KGQ T YRFLA+ GG++W Q+ AT+V R + IV V+++++ E
Sbjct: 231 SKSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEE 290
Query: 338 KGLQLSLDQ 346
G+ LSL+Q
Sbjct: 291 TGVVLSLEQ 299
>gi|71852582 aryl hydrocarbon receptor nuclear translocator-like
isoform b [Homo sapiens]
Length = 582
Score = 130 bits (326), Expect = 6e-30
Identities = 110/391 (28%), Positives = 180/391 (46%), Gaps = 48/391 (12%)
Query: 2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLG 61
+E + RR+K NS ELA L+P +A++ +LDK +++R+ ++K
Sbjct: 31 REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYT 90
Query: 62 EAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPD-GKIMYISETASVHLGLSQVELT 120
EA P EL +L+ DGF+FVV D GKI+++SE+ L SQ +L
Sbjct: 91 EA-----NYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLI 145
Query: 121 GNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEI-------------------ERSFF 161
G S+++Y+HP D ++ L++ + + + RSFF
Sbjct: 146 GQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFF 205
Query: 162 LRMKC-----VLAKRNAGLTCGGYK------VIHCSGYLKI---RQYSLDMS---PFDGC 204
RMKC + ++ TC K IH +GYLK + LD +GC
Sbjct: 206 CRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGC 265
Query: 205 YQNVGLVAVG----HSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDL 260
+ LVA+G H +P EI++ S ++ R ++D K +F+D R + Y PQ+L
Sbjct: 266 NLSC-LVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQEL 324
Query: 261 IEKTLYHHVHGCDTFHL-RCAHHLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRS 319
+ + Y + H D HL C +L + ++TT Y+F K G ++ ++S N +
Sbjct: 325 LGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWT 384
Query: 320 SRPHCIVSVNYVLTDTEYKGLQLSLDQISAS 350
IVS N V+ +G + Q++AS
Sbjct: 385 KEVEYIVSTNTVVLANVLEGGDPTFPQLTAS 415
>gi|71852580 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 130 bits (326), Expect = 6e-30
Identities = 110/391 (28%), Positives = 180/391 (46%), Gaps = 48/391 (12%)
Query: 2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLG 61
+E + RR+K NS ELA L+P +A++ +LDK +++R+ ++K
Sbjct: 74 REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYT 133
Query: 62 EAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPD-GKIMYISETASVHLGLSQVELT 120
EA P EL +L+ DGF+FVV D GKI+++SE+ L SQ +L
Sbjct: 134 EA-----NYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLI 188
Query: 121 GNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEI-------------------ERSFF 161
G S+++Y+HP D ++ L++ + + + RSFF
Sbjct: 189 GQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFF 248
Query: 162 LRMKC-----VLAKRNAGLTCGGYK------VIHCSGYLKI---RQYSLDMS---PFDGC 204
RMKC + ++ TC K IH +GYLK + LD +GC
Sbjct: 249 CRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGC 308
Query: 205 YQNVGLVAVG----HSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDL 260
+ LVA+G H +P EI++ S ++ R ++D K +F+D R + Y PQ+L
Sbjct: 309 NLSC-LVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQEL 367
Query: 261 IEKTLYHHVHGCDTFHL-RCAHHLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRS 319
+ + Y + H D HL C +L + ++TT Y+F K G ++ ++S N +
Sbjct: 368 LGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWT 427
Query: 320 SRPHCIVSVNYVLTDTEYKGLQLSLDQISAS 350
IVS N V+ +G + Q++AS
Sbjct: 428 KEVEYIVSTNTVVLANVLEGGDPTFPQLTAS 458
>gi|42716311 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 130 bits (326), Expect = 6e-30
Identities = 110/391 (28%), Positives = 180/391 (46%), Gaps = 48/391 (12%)
Query: 2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLG 61
+E + RR+K NS ELA L+P +A++ +LDK +++R+ ++K
Sbjct: 74 REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYT 133
Query: 62 EAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPD-GKIMYISETASVHLGLSQVELT 120
EA P EL +L+ DGF+FVV D GKI+++SE+ L SQ +L
Sbjct: 134 EA-----NYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLI 188
Query: 121 GNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEI-------------------ERSFF 161
G S+++Y+HP D ++ L++ + + + RSFF
Sbjct: 189 GQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFF 248
Query: 162 LRMKC-----VLAKRNAGLTCGGYK------VIHCSGYLKI---RQYSLDMS---PFDGC 204
RMKC + ++ TC K IH +GYLK + LD +GC
Sbjct: 249 CRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGC 308
Query: 205 YQNVGLVAVG----HSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDL 260
+ LVA+G H +P EI++ S ++ R ++D K +F+D R + Y PQ+L
Sbjct: 309 NLSC-LVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQEL 367
Query: 261 IEKTLYHHVHGCDTFHL-RCAHHLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRS 319
+ + Y + H D HL C +L + ++TT Y+F K G ++ ++S N +
Sbjct: 368 LGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWT 427
Query: 320 SRPHCIVSVNYVLTDTEYKGLQLSLDQISAS 350
IVS N V+ +G + Q++AS
Sbjct: 428 KEVEYIVSTNTVVLANVLEGGDPTFPQLTAS 458
>gi|4502003 aryl hydrocarbon receptor [Homo sapiens]
Length = 848
Score = 122 bits (305), Expect = 2e-27
Identities = 95/368 (25%), Positives = 159/368 (43%), Gaps = 49/368 (13%)
Query: 7 NAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLGEAWGH 66
N ++ R++ N+E LA LLP P + ++LDK S++RL+ SYL+ + F L +
Sbjct: 34 NPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSS--P 91
Query: 67 SSRTSPLDN---------VGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQV 117
+ R DN + + G LLQ L+GF+ VV D + Y S T +LG Q
Sbjct: 92 TERNGGQDNCRAANFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASSTIQDYLGFQQS 151
Query: 118 ELTGNSIYEYIHPADHDE--------------------------MTAVLTAHQPYHSHFV 151
++ S+YE IH D E + + + P
Sbjct: 152 DVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLPQTVVCYNPDQIPPE 211
Query: 152 QEYEIERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDGCY--QNVG 209
+ER F R++C+L + G+ ++ G LK + DG +
Sbjct: 212 NSPLMERCFICRLRCLLDNSS------GFLAMNFQGKLKY-LHGQKKKGKDGSILPPQLA 264
Query: 210 LVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEK-TLYHH 268
L A+ L P ++ EI+ + +F + LD I D++ + GY +L + + Y
Sbjct: 265 LFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTEAELCTRGSGYQF 324
Query: 269 VHGCDTFHLRCAHHLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSV 328
+H D + +H ++ G+ +R L K+ W WVQS A +++ ++ RP I+
Sbjct: 325 IHAADMLYCAESHIRMIKTGESGMIVFRLLTKNNRWTWVQSNARLLY--KNGRPDYIIVT 382
Query: 329 NYVLTDTE 336
LTD E
Sbjct: 383 QRPLTDEE 390
>gi|31745180 aryl hydrocarbon receptor nuclear translocator-like 2
[Homo sapiens]
Length = 636
Score = 119 bits (298), Expect = 1e-26
Identities = 105/373 (28%), Positives = 174/373 (46%), Gaps = 57/373 (15%)
Query: 2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLG 61
+E + RR+K N+ EL+ ++P + + +LDK +++R+ +L+ +GL
Sbjct: 109 REAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSL----KGLT 164
Query: 62 EAW-GHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPD-GKIMYISETASVHLGLSQVEL 119
++ G + R S L + EL +L+T +GF+FVV + GKI+++S++ S L Q L
Sbjct: 165 NSYVGSNYRPSFLQD--NELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASL 222
Query: 120 TGNSIYEYIHPADHDEMTAVLTA------------------HQPYHSHFVQEYE-IERSF 160
TG S+++++HP D ++ L++ H H+ + Y RSF
Sbjct: 223 TGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRSF 282
Query: 161 FLRMKC--VLAKRNAGLTCGGYK-------VIHCSGYLKI-----------RQYSLDMSP 200
F R+K + K G K IHC+GYL+ R D S
Sbjct: 283 FCRIKSCKISVKEEHGCLPNSKKKEHRKFYTIHCTGYLRSWPPNIVGMEEERNSKKDNSN 342
Query: 201 FDGCYQNVGLVAVGHSLP---PSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEP 257
F C LVA+G P P EI + F+ R +++ K +++D R + GY P
Sbjct: 343 FT-C-----LVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLP 396
Query: 258 QDLIEKTLYHHVHGCDTFHLRCAHHLLL-VKGQVTTKYYRFLAKHGGWVWVQSYATIVHN 316
Q+L+ + Y + H D +L H +L K ++ T Y+F AK G +V ++S N
Sbjct: 397 QELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFTN 456
Query: 317 SRSSRPHCIVSVN 329
+ IVSVN
Sbjct: 457 PWTKELEYIVSVN 469
>gi|4758010 clock [Homo sapiens]
Length = 846
Score = 113 bits (283), Expect = 6e-25
Identities = 111/447 (24%), Positives = 195/447 (43%), Gaps = 46/447 (10%)
Query: 2 KEKSKNAARTRREKENSEFY-----ELAKLLPLPSAITSQLDKASIIRLTTSYL-KMRVV 55
K+K+K +R + EK+ + + EL +LP ++DK+++++ + +L K + +
Sbjct: 31 KDKAKRVSRNKSEKKRRDQFNVLIKELGSMLP---GNARKMDKSTVLQKSIDFLRKHKEI 87
Query: 56 FPEGLGEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLS 115
+ + + L N E +L+ LDGF + DG I+Y+SE+ + L
Sbjct: 88 TAQSDASEIRQDWKPTFLSN--EEFTQLMLEALDGFFLAIMTDGSIIYVSESVTSLLEHL 145
Query: 116 QVELTGNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAG- 174
+L SI+ +I +H E+ +L+ H EY ++ L C + +
Sbjct: 146 PSDLVDQSIFNFIPEGEHSEVYKILSTHLLESDSLTPEY-LKSKNQLEFCCHMLRGTIDP 204
Query: 175 LTCGGYKVIHCSGYLKIRQY--SLDMSPFDGCYQN---------VGLVAVGHSLPPSAVT 223
Y+ + G K S + F+G Q V VA P +
Sbjct: 205 KEPSTYEYVKFIGNFKSLNSVSSSAHNGFEGTIQRTHRPSYEDRVCFVATVRLATPQFIK 264
Query: 224 E---IKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCA 280
E ++ + F R SL+ K +FLD R + GY P +++ + Y + H D +L
Sbjct: 265 EMCTVEEPNEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVDDLENLAKC 324
Query: 281 HHLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYK-- 338
H L+ G+ + YYRFL K W+W+Q++ I ++ +SRP IV + V++ E +
Sbjct: 325 HEHLMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYHQWNSRPEFIVCTHTVVSYAEVRAE 384
Query: 339 -----GLQLSLDQISASKPAFSYTSSSTPTMTDNRKGAKSRLSSSKSKSRTSPYPQYSGF 393
G++ SL + +A K S + +DNR S L + + SP P S
Sbjct: 385 RRRELGIEESLPETAADK--------SQDSGSDNRINTVS-LKEALERFDHSPTPSASSR 435
Query: 394 HTERSESDHDSQWGGSPL---TDTASP 417
+ +S S +P TDT++P
Sbjct: 436 SSRKSSHTAVSDPSSTPTKIPTDTSTP 462
>gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Homo
sapiens]
Length = 717
Score = 113 bits (282), Expect = 8e-25
Identities = 100/394 (25%), Positives = 173/394 (43%), Gaps = 55/394 (13%)
Query: 2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLK-MRVVFPEGL 60
+E R RR K EL+ ++P SA+ + DK +I+R+ S++K MR +
Sbjct: 65 RENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMKSMRGTGNKST 124
Query: 61 GEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPD-GKIMYISETASVHLGLSQVEL 119
A+ S T +EL +L+ DGF+FVVA + G+++Y+S++ + L Q E
Sbjct: 125 DGAYKPSFLTE------QELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNQPQSEW 178
Query: 120 TGNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEI------------------ERSFF 161
G+++YE +HP D +++ L + + + + + RSF
Sbjct: 179 FGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFI 238
Query: 162 LRMKCVLA-----------------KRNAGLTCGG---YKVIHCSGYLKIRQYSLDMSPF 201
RM+C A + G G Y V+HC+GY+K + P
Sbjct: 239 CRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKAWPPAGMTIPE 298
Query: 202 DGCYQNVG----LVAVGHSLPPSAVTEIKLHS----NMFMFRASLDMKLIFLDSRVAELT 253
+ G LVA+G S+ + ++ F+ R + D + F+D R +
Sbjct: 299 EDADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVPTEFLSRHNSDGIITFVDPRCISVI 358
Query: 254 GYEPQDLIEKTLYHHVHGCDTFHLR-CAHHLLLVKGQVTTKYYRFLAKHGGWVWVQSYAT 312
GY+PQDL+ K + H D HLR ++ +KGQV + YRF K+ W+ +++ +
Sbjct: 359 GYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNREWMLIRTSSF 418
Query: 313 IVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQ 346
N S I+ N + + + +L + Q
Sbjct: 419 TFQNPYSDEIEYIICTNTNVKQLQQQQAELEVHQ 452
>gi|30795242 aryl hydrocarbon receptor nuclear translocator isoform
3 [Homo sapiens]
Length = 774
Score = 106 bits (264), Expect = 9e-23
Identities = 94/376 (25%), Positives = 164/376 (43%), Gaps = 53/376 (14%)
Query: 2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLG 61
+E R RR K + EL+ ++P SA+ + DK +I+R+ S++K G G
Sbjct: 76 RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSL----RGTG 131
Query: 62 EAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPD-GKIMYISETASVHLGLSQVELT 120
S P +EL +L+ DGF+F+V+ + G+++Y+S++ + L Q E
Sbjct: 132 NTSTDGSY-KPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWF 190
Query: 121 GNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEI------------------ERSFFL 162
G+++Y+ +HP D D++ L+ + + + + + RSF
Sbjct: 191 GSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFIC 250
Query: 163 RMKCVLA-----------------KRNAGLTCGG---YKVIHCSGYLKI---RQYSL-DM 198
RM+C + + G G + V+HC+GY+K SL D
Sbjct: 251 RMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDD 310
Query: 199 SPFDGCYQNVGLVAVGH----SLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTG 254
P G LVA+G S P F+ R +++ F+D R G
Sbjct: 311 DPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVG 370
Query: 255 YEPQDLIEKTLYHHVHGCDTFHLRCA-HHLLLVKGQVTTKYYRFLAKHGGWVWVQSYATI 313
Y+PQ+L+ K + H D LR + ++ +KGQV + +RF +K+ W+W+++ +
Sbjct: 371 YQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSSFT 430
Query: 314 VHNSRSSRPHCIVSVN 329
N S I+ N
Sbjct: 431 FQNPYSDEIEYIICTN 446
>gi|4502231 aryl hydrocarbon receptor nuclear translocator isoform 1
[Homo sapiens]
Length = 789
Score = 106 bits (264), Expect = 9e-23
Identities = 94/376 (25%), Positives = 164/376 (43%), Gaps = 53/376 (14%)
Query: 2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLG 61
+E R RR K + EL+ ++P SA+ + DK +I+R+ S++K G G
Sbjct: 91 RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSL----RGTG 146
Query: 62 EAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPD-GKIMYISETASVHLGLSQVELT 120
S P +EL +L+ DGF+F+V+ + G+++Y+S++ + L Q E
Sbjct: 147 NTSTDGSY-KPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWF 205
Query: 121 GNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEI------------------ERSFFL 162
G+++Y+ +HP D D++ L+ + + + + + RSF
Sbjct: 206 GSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFIC 265
Query: 163 RMKCVLA-----------------KRNAGLTCGG---YKVIHCSGYLKI---RQYSL-DM 198
RM+C + + G G + V+HC+GY+K SL D
Sbjct: 266 RMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDD 325
Query: 199 SPFDGCYQNVGLVAVGH----SLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTG 254
P G LVA+G S P F+ R +++ F+D R G
Sbjct: 326 DPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVG 385
Query: 255 YEPQDLIEKTLYHHVHGCDTFHLRCA-HHLLLVKGQVTTKYYRFLAKHGGWVWVQSYATI 313
Y+PQ+L+ K + H D LR + ++ +KGQV + +RF +K+ W+W+++ +
Sbjct: 386 YQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSSFT 445
Query: 314 VHNSRSSRPHCIVSVN 329
N S I+ N
Sbjct: 446 FQNPYSDEIEYIICTN 461
>gi|194097477 neuronal PAS domain protein 4 [Homo sapiens]
Length = 802
Score = 96.3 bits (238), Expect = 1e-19
Identities = 99/380 (26%), Positives = 154/380 (40%), Gaps = 44/380 (11%)
Query: 1 MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGL 60
M +K A++ RR++ N+E L +LLPL A +L I+ L Y + V F G
Sbjct: 1 MYRSTKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGT 60
Query: 61 GEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELT 120
A P + + ++ L GF+ V +GK++Y+SE+ S HLG S V+L
Sbjct: 61 PLA-------GPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLV 113
Query: 121 --GNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCG 178
G+SIY+ I PADH + LT + +R F R + R
Sbjct: 114 AQGDSIYDIIDPADHLTVRQQLT--------LPSALDTDRLFRCRFNTSKSLRRQS---A 162
Query: 179 GYKVIHCSGYLKIRQYSLDMSPFDGCY--QNVGLVAVGHSLPP-------SAVTEIKLHS 229
G K++ G G Y N A L P L
Sbjct: 163 GNKLVLIRGRFHAHP--------PGAYWAGNPVFTAFCAPLEPRPRPGPGPGPGPASLFL 214
Query: 230 NMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVK-G 288
MF R + D+ L+ + V G+E +L+ K+ Y +H D H H+ LL + G
Sbjct: 215 AMFQSRHAKDLALLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESG 274
Query: 289 QVTTK-YYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQI 347
+ + R AK GGW W+ ++++ P I + NY ++D E L+ L+
Sbjct: 275 DIQAEMVVRLQAKTGGWAWIY---CLLYSEGPEGP--ITANNYPISDMEAWSLRQQLNSE 329
Query: 348 SASKPAFSYTSSSTPTMTDN 367
T + P+ +N
Sbjct: 330 DTQAAYVLGTPTMLPSFPEN 349
>gi|22027471 neuronal PAS domain protein 2 [Homo sapiens]
Length = 824
Score = 93.2 bits (230), Expect = 8e-19
Identities = 89/359 (24%), Positives = 160/359 (44%), Gaps = 39/359 (10%)
Query: 2 KEKSKNAARTRREKENSEFY-----ELAKLLPLPSAITSQLDKASIIRLTTSYL-KMRVV 55
K+++K A+R + EK+ + + EL+ +LP T ++DK +++ +L K V
Sbjct: 6 KDRAKRASRNKSEKKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGFLQKHNEV 62
Query: 56 FPE----GLGEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVH 111
+ + + W + S L N E +L+ LDGFI V DG I+Y+S++ +
Sbjct: 63 SAQTEICDIQQDW----KPSFLSN--EEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPL 116
Query: 112 LGLSQVELTGNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKR 171
LG ++ ++ ++ +H E+ +L++H EY ++ L C L +
Sbjct: 117 LGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEY-LKSDSDLEFYCHLLRG 175
Query: 172 NAG-LTCGGYKVIHCSGYLKIRQYSLDMSPFDGCYQN-------------VGLVAVGHSL 217
+ Y+ I G R Y+ SP + N V +A
Sbjct: 176 SLNPKEFPTYEYIKFVG--NFRSYNNVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLA 233
Query: 218 PPSAVTEIKLHSNM---FMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDT 274
P + E+ + F R SL+ K +FLD R + GY P +++ + Y + H D
Sbjct: 234 TPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDL 293
Query: 275 FHLRCAHHLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLT 333
L H L+ G+ + YRFL K W+W+Q++ I ++ +S+P IV + V++
Sbjct: 294 ELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVVS 352
>gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens]
Length = 1399
Score = 92.0 bits (227), Expect = 2e-18
Identities = 102/425 (24%), Positives = 183/425 (43%), Gaps = 59/425 (13%)
Query: 5 SKNAARTRREKENSEFYELAKLLPLP----SAITSQLDKASIIRLTTSYLKM-------R 53
+ + + RRE+EN ELA+LL +++ + DK I++ T +++ +
Sbjct: 28 ASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEK 87
Query: 54 VVFPEGLGEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLG 113
+ + ++ SS ++ LG LL+ LDGF FVV +G+I+++SE + +LG
Sbjct: 88 STTDDDVQKSDISSSSQGVIEK--ESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLG 145
Query: 114 LSQVELTGNSIYEYIHPADHDEMTAVLTAHQPYHS-HFVQEYEIERSFFLRMKCVLAKRN 172
+Q EL S+Y +H DH E L + + QE S + ++ +
Sbjct: 146 YNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPD 205
Query: 173 AGLT-----CGGYKVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLP-PSAVTEIK 226
T C Y+V+ C + + D F C L+ + LP P A+T ++
Sbjct: 206 EPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQSC-----LICIARRLPRPPAITGVE 260
Query: 227 LHSNMFMFRASLDMKLIFLDS---RVAELTGYEPQDLIEKTLY--HHVHGCDTFHLRCAH 281
FM + K+I +D+ R A TG+E DL+ K +Y G + + R
Sbjct: 261 ----SFMTKQDTTGKIISIDTSSLRAAGRTGWE--DLVRKCIYAFFQPQGREPSYARQLF 314
Query: 282 HLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQ 341
++ +G ++ YRF+ G + + + + I+ ++ + D E+ GL
Sbjct: 315 QEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMGIHII--DREHSGLS 372
Query: 342 --------LSLDQISAS-----KPAFSYTSSST--PTMTD------NRKGAKSRLSSSKS 380
+S+ +++ S PA SST P+ ++ NR+ + SSS S
Sbjct: 373 PQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINRQQSSDLHSSSHS 432
Query: 381 KSRTS 385
S S
Sbjct: 433 NSSNS 437
>gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens]
Length = 1440
Score = 92.0 bits (227), Expect = 2e-18
Identities = 102/425 (24%), Positives = 183/425 (43%), Gaps = 59/425 (13%)
Query: 5 SKNAARTRREKENSEFYELAKLLPLP----SAITSQLDKASIIRLTTSYLKM-------R 53
+ + + RRE+EN ELA+LL +++ + DK I++ T +++ +
Sbjct: 28 ASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEK 87
Query: 54 VVFPEGLGEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLG 113
+ + ++ SS ++ LG LL+ LDGF FVV +G+I+++SE + +LG
Sbjct: 88 STTDDDVQKSDISSSSQGVIEK--ESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLG 145
Query: 114 LSQVELTGNSIYEYIHPADHDEMTAVLTAHQPYHS-HFVQEYEIERSFFLRMKCVLAKRN 172
+Q EL S+Y +H DH E L + + QE S + ++ +
Sbjct: 146 YNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPD 205
Query: 173 AGLT-----CGGYKVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLP-PSAVTEIK 226
T C Y+V+ C + + D F C L+ + LP P A+T ++
Sbjct: 206 EPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQSC-----LICIARRLPRPPAITGVE 260
Query: 227 LHSNMFMFRASLDMKLIFLDS---RVAELTGYEPQDLIEKTLY--HHVHGCDTFHLRCAH 281
FM + K+I +D+ R A TG+E DL+ K +Y G + + R
Sbjct: 261 ----SFMTKQDTTGKIISIDTSSLRAAGRTGWE--DLVRKCIYAFFQPQGREPSYARQLF 314
Query: 282 HLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQ 341
++ +G ++ YRF+ G + + + + I+ ++ + D E+ GL
Sbjct: 315 QEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMGIHII--DREHSGLS 372
Query: 342 --------LSLDQISAS-----KPAFSYTSSST--PTMTD------NRKGAKSRLSSSKS 380
+S+ +++ S PA SST P+ ++ NR+ + SSS S
Sbjct: 373 PQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINRQQSSDLHSSSHS 432
Query: 381 KSRTS 385
S S
Sbjct: 433 NSSNS 437
>gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens]
Length = 1441
Score = 92.0 bits (227), Expect = 2e-18
Identities = 102/425 (24%), Positives = 183/425 (43%), Gaps = 59/425 (13%)
Query: 5 SKNAARTRREKENSEFYELAKLLPLP----SAITSQLDKASIIRLTTSYLKM-------R 53
+ + + RRE+EN ELA+LL +++ + DK I++ T +++ +
Sbjct: 28 ASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEK 87
Query: 54 VVFPEGLGEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLG 113
+ + ++ SS ++ LG LL+ LDGF FVV +G+I+++SE + +LG
Sbjct: 88 STTDDDVQKSDISSSSQGVIEK--ESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLG 145
Query: 114 LSQVELTGNSIYEYIHPADHDEMTAVLTAHQPYHS-HFVQEYEIERSFFLRMKCVLAKRN 172
+Q EL S+Y +H DH E L + + QE S + ++ +
Sbjct: 146 YNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPD 205
Query: 173 AGLT-----CGGYKVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLP-PSAVTEIK 226
T C Y+V+ C + + D F C L+ + LP P A+T ++
Sbjct: 206 EPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQSC-----LICIARRLPRPPAITGVE 260
Query: 227 LHSNMFMFRASLDMKLIFLDS---RVAELTGYEPQDLIEKTLY--HHVHGCDTFHLRCAH 281
FM + K+I +D+ R A TG+E DL+ K +Y G + + R
Sbjct: 261 ----SFMTKQDTTGKIISIDTSSLRAAGRTGWE--DLVRKCIYAFFQPQGREPSYARQLF 314
Query: 282 HLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQ 341
++ +G ++ YRF+ G + + + + I+ ++ + D E+ GL
Sbjct: 315 QEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMGIHII--DREHSGLS 372
Query: 342 --------LSLDQISAS-----KPAFSYTSSST--PTMTD------NRKGAKSRLSSSKS 380
+S+ +++ S PA SST P+ ++ NR+ + SSS S
Sbjct: 373 PQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINRQQSSDLHSSSHS 432
Query: 381 KSRTS 385
S S
Sbjct: 433 NSSNS 437
>gi|115430245 arylhydrocarbon receptor repressor [Homo sapiens]
Length = 719
Score = 79.0 bits (193), Expect = 2e-14
Identities = 52/140 (37%), Positives = 76/140 (54%), Gaps = 8/140 (5%)
Query: 3 EKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVF-----P 57
EKS N ++ R++ N+E LA LLP P I S+LDK S++RL+ SYL+++ F
Sbjct: 32 EKS-NPSKRHRDRLNAELDHLASLLPFPPDIISKLDKLSVLRLSVSYLRVKSFFQVVQEQ 90
Query: 58 EGLGEAWGHSS--RTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLS 115
A G S + PL G LL++L+GF VV+ +G I Y S T +LG
Sbjct: 91 SSRQPAAGAPSPGDSCPLAGSAVLEGRLLLESLNGFALVVSAEGTIFYASATIVDYLGFH 150
Query: 116 QVELTGNSIYEYIHPADHDE 135
Q ++ +IY+YIH D +
Sbjct: 151 QTDVMHQNIYDYIHVDDRQD 170
>gi|5729858 nuclear receptor coactivator 2 [Homo sapiens]
Length = 1464
Score = 75.5 bits (184), Expect = 2e-13
Identities = 88/391 (22%), Positives = 158/391 (40%), Gaps = 43/391 (10%)
Query: 6 KNAARTRREKENSEFYELAKLLPLP----SAITSQLDKASIIRLTTSYLKMRVVFPEGLG 61
+N + RE+EN ELA+L+ + DK +I++ T ++ ++ E
Sbjct: 32 RNTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIR-QIKEQEKAA 90
Query: 62 EAWGHSSRTSPLDNVGR------ELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLS 115
A + S + + G+ LG +L+ LDGF FVV +G ++++SE + +L +
Sbjct: 91 AANIDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFVVNLEGNVVFVSENVTQYLRYN 150
Query: 116 QVELTGNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGL 175
Q EL S+Y +H DH E L + R+ +L K
Sbjct: 151 QEELMNKSVYSILHVGDHTEFVKNLLPKSIVNGGSWSGEPPRRNSHTFNCRMLVKPLPDS 210
Query: 176 TCGG---------YKVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIK 226
G Y+ + C + + + C L+ V +P +
Sbjct: 211 EEEGHDNQEAHQKYETMQCFAVSQPKSIKEEGEDLQSC-----LICVARRVPMKE-RPVL 264
Query: 227 LHSNMFMFRASLDMKLIFLDS---RVAELTGYEPQDLIEKTL--YHHVH-GCDTFHLRCA 280
S F R L K+ LD+ R A G+E DL+ + + +H H G + +
Sbjct: 265 PSSESFTTRQDLQGKITSLDTSTMRAAMKPGWE--DLVRRCIQKFHAQHEGESVSYAKRH 322
Query: 281 HHLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSV-------NYVLT 333
HH +L +G ++ YRF G V Q+ + ++ + ++ P ++S+ N +
Sbjct: 323 HHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQTTNEPQLVISLHMLHREQNVCVM 382
Query: 334 DTEYKGLQLS--LDQISASKPAFSYTSSSTP 362
+ + G + L+ IS++ PA S P
Sbjct: 383 NPDLTGQTMGKPLNPISSNSPAHQALCSGNP 413
>gi|30795240 aryl hydrocarbon receptor nuclear translocator isoform
2 [Homo sapiens]
Length = 328
Score = 68.6 bits (166), Expect = 2e-11
Identities = 55/228 (24%), Positives = 101/228 (44%), Gaps = 44/228 (19%)
Query: 2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLG 61
+E R RR K + EL+ ++P SA+ + DK +I+R+ S++K G G
Sbjct: 91 RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSL----RGTG 146
Query: 62 EAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPD-GKIMYISETASVHLGLSQVELT 120
S P +EL +L+ DGF+F+V+ + G+++Y+S++ + L Q E
Sbjct: 147 NTSTDGSY-KPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWF 205
Query: 121 GNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEI------------------ERSFFL 162
G+++Y+ +HP D D++ L+ + + + + + RSF
Sbjct: 206 GSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFIC 265
Query: 163 RMKCVLA-----------------KRNAGLTCGG---YKVIHCSGYLK 190
RM+C + + G G + V+HC+GY+K
Sbjct: 266 RMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIK 313
>gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens]
Length = 1424
Score = 63.9 bits (154), Expect = 5e-10
Identities = 81/349 (23%), Positives = 147/349 (42%), Gaps = 41/349 (11%)
Query: 10 RTRREKENSEFYELAKLLPLPSAITSQLD-------KASIIRLTTSYLKMRVVFPEGLGE 62
+ RRE+E+ ELA+L+ SA S +D K +I++ T ++R + +G
Sbjct: 35 KRRREQESKYIEELAELI---SANLSDIDNFNVKPDKCAILKETVR--QIRQIKEQGKTI 89
Query: 63 AWGHSSRTSPLDNVGR------ELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQ 116
+ + + + + G+ LG LLQ LDGF+FVV DG I+++SE + +L Q
Sbjct: 90 SNDDDVQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQ 149
Query: 117 VELTGNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERS--FFLRMKC-----VLA 169
+L S+Y +H D + L + E + ++S F RM +L
Sbjct: 150 EDLVNTSVYNILHEEDRKDFLKNLPKSTVNGVSWTNETQRQKSHTFNCRMLMKTPHDILE 209
Query: 170 KRNAGLTC-GGYKVIHCSGYLKIRQYSLDMSPFDGCYQNVG-LVAVGHSLPPSAVTEIKL 227
NA Y+ + C + R + C V + G PS
Sbjct: 210 DINASPEMRQRYETMQCFALSQPRAMMEEGEDLQSCMICVARRITTGERTFPS------- 262
Query: 228 HSNMFMFRASLDMKLIFLDS---RVAELTGYEPQDLIEKTL--YHHVHGCDTFHLRCAHH 282
+ F+ R L K++ +D+ R + G+E D+I + + + ++ ++ + +
Sbjct: 263 NPESFITRHDLSGKVVNIDTNSLRSSMRPGFE--DIIRRCIQRFFSLNDGQSWSQKRHYQ 320
Query: 283 LLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYV 331
+ G T YRF G V Q+ + + N ++ H VS +++
Sbjct: 321 EAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRNPVTNDRHGFVSTHFL 369
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.131 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,279,739
Number of Sequences: 37866
Number of extensions: 1487509
Number of successful extensions: 4663
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 41
Number of HSP's successfully gapped in prelim test: 45
Number of HSP's that attempted gapping in prelim test: 4384
Number of HSP's gapped (non-prelim): 223
length of query: 766
length of database: 18,247,518
effective HSP length: 110
effective length of query: 656
effective length of database: 14,082,258
effective search space: 9237961248
effective search space used: 9237961248
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.