Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 21361831
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21361831 partitioning-defective protein 3 homolog [Homo
sapiens]
(1356 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens] 2714 0.0
gi|119120907 par-3 partitioning defective 3 homolog B isoform a ... 536 e-152
gi|119120903 par-3 partitioning defective 3 homolog B isoform c ... 459 e-128
gi|119120897 par-3 partitioning defective 3 homolog B isoform b ... 301 4e-81
gi|148746189 multiple PDZ domain protein [Homo sapiens] 114 5e-25
gi|112382257 InaD-like [Homo sapiens] 107 8e-23
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 95 5e-19
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 95 5e-19
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 95 5e-19
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 92 4e-18
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom... 89 2e-17
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 88 5e-17
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 88 5e-17
gi|218505835 membrane-associated guanylate kinase-related 3 iso... 86 2e-16
gi|155969695 membrane-associated guanylate kinase-related 3 iso... 86 2e-16
gi|24025688 ligand of numb-protein X 2 [Homo sapiens] 86 2e-16
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 84 9e-16
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 84 9e-16
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 84 9e-16
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom... 84 1e-15
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom... 83 2e-15
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 82 3e-15
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 82 5e-15
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 82 5e-15
gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens] 81 8e-15
gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens] 81 8e-15
gi|45827729 scribble isoform b [Homo sapiens] 79 3e-14
gi|45827731 scribble isoform a [Homo sapiens] 79 3e-14
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom... 79 4e-14
gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo sa... 77 1e-13
>gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]
Length = 1356
Score = 2714 bits (7035), Expect = 0.0
Identities = 1356/1356 (100%), Positives = 1356/1356 (100%)
Query: 1 MKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWIQVHRLEHGDGGILD 60
MKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWIQVHRLEHGDGGILD
Sbjct: 1 MKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWIQVHRLEHGDGGILD 60
Query: 61 LDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQ 120
LDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQ
Sbjct: 61 LDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQ 120
Query: 121 ATSEIEVTPSVLRANMPLHVRRSSDPALIGLSTSVSDSNFSSEEPSRKNPTRWSTTAGFL 180
ATSEIEVTPSVLRANMPLHVRRSSDPALIGLSTSVSDSNFSSEEPSRKNPTRWSTTAGFL
Sbjct: 121 ATSEIEVTPSVLRANMPLHVRRSSDPALIGLSTSVSDSNFSSEEPSRKNPTRWSTTAGFL 180
Query: 181 KQNTAGSPKTCDRKKDENYRSLPRDTSNWSNQFQRDNARSSLSASHPMVGKWLEKQEQDE 240
KQNTAGSPKTCDRKKDENYRSLPRDTSNWSNQFQRDNARSSLSASHPMVGKWLEKQEQDE
Sbjct: 181 KQNTAGSPKTCDRKKDENYRSLPRDTSNWSNQFQRDNARSSLSASHPMVGKWLEKQEQDE 240
Query: 241 DGTEEDNSRVEPVGHADTGLEHIPNFSLDDMVKLVEVPNDGGPLGIHVVPFSARGGRTLG 300
DGTEEDNSRVEPVGHADTGLEHIPNFSLDDMVKLVEVPNDGGPLGIHVVPFSARGGRTLG
Sbjct: 241 DGTEEDNSRVEPVGHADTGLEHIPNFSLDDMVKLVEVPNDGGPLGIHVVPFSARGGRTLG 300
Query: 301 LLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPA 360
LLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPA
Sbjct: 301 LLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPA 360
Query: 361 ANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAPRLNHPPEQIDSHSR 420
ANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAPRLNHPPEQIDSHSR
Sbjct: 361 ANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAPRLNHPPEQIDSHSR 420
Query: 421 LPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDV 480
LPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDV
Sbjct: 421 LPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDV 480
Query: 481 TIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTV 540
TIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTV
Sbjct: 481 TIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTV 540
Query: 541 SLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAG 600
SLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAG
Sbjct: 541 SLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAG 600
Query: 601 LGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAME 660
LGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAME
Sbjct: 601 LGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAME 660
Query: 661 TLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDRERRISHSLYS 720
TLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDRERRISHSLYS
Sbjct: 661 TLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDRERRISHSLYS 720
Query: 721 GIEGLDESPSRNAALSRIMGESGKYQLSPTVNMPQDDTVIIEDDRLPVLPPHLSDQSSSS 780
GIEGLDESPSRNAALSRIMGESGKYQLSPTVNMPQDDTVIIEDDRLPVLPPHLSDQSSSS
Sbjct: 721 GIEGLDESPSRNAALSRIMGESGKYQLSPTVNMPQDDTVIIEDDRLPVLPPHLSDQSSSS 780
Query: 781 SHDDVGFVTADAGTWAKAAISDSADCSLSPDVDPVLAFQREGFGRQSMSEKRTKQFSDAS 840
SHDDVGFVTADAGTWAKAAISDSADCSLSPDVDPVLAFQREGFGRQSMSEKRTKQFSDAS
Sbjct: 781 SHDDVGFVTADAGTWAKAAISDSADCSLSPDVDPVLAFQREGFGRQSMSEKRTKQFSDAS 840
Query: 841 QLDFVKTRKSKSMDLGIADETKLNTVDDQKAGSPSRDVGPSLGLKKSSSLESLQTAVAEV 900
QLDFVKTRKSKSMDLGIADETKLNTVDDQKAGSPSRDVGPSLGLKKSSSLESLQTAVAEV
Sbjct: 841 QLDFVKTRKSKSMDLGIADETKLNTVDDQKAGSPSRDVGPSLGLKKSSSLESLQTAVAEV 900
Query: 901 TLNGDIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPAVDDDDEGMETLEEDTEESSRSGR 960
TLNGDIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPAVDDDDEGMETLEEDTEESSRSGR
Sbjct: 901 TLNGDIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPAVDDDDEGMETLEEDTEESSRSGR 960
Query: 961 ESVSTASDQPSHSLERQMNGNQEKGDKTDRKKDKTGKEKKKDRDKEKDKMKAKKGMLKGL 1020
ESVSTASDQPSHSLERQMNGNQEKGDKTDRKKDKTGKEKKKDRDKEKDKMKAKKGMLKGL
Sbjct: 961 ESVSTASDQPSHSLERQMNGNQEKGDKTDRKKDKTGKEKKKDRDKEKDKMKAKKGMLKGL 1020
Query: 1021 GDMFRFGKHRKDDKIEKTGKIKIQESFTSEEERIRMKQEQERIQAKTREFRERQARERDY 1080
GDMFRFGKHRKDDKIEKTGKIKIQESFTSEEERIRMKQEQERIQAKTREFRERQARERDY
Sbjct: 1021 GDMFRFGKHRKDDKIEKTGKIKIQESFTSEEERIRMKQEQERIQAKTREFRERQARERDY 1080
Query: 1081 AEIQDFHRTFGCDDELMYGGVSSYEGSMALNARPQSPREGHMMDALYAQVKKPRNSKPSP 1140
AEIQDFHRTFGCDDELMYGGVSSYEGSMALNARPQSPREGHMMDALYAQVKKPRNSKPSP
Sbjct: 1081 AEIQDFHRTFGCDDELMYGGVSSYEGSMALNARPQSPREGHMMDALYAQVKKPRNSKPSP 1140
Query: 1141 VDSNRSTPSNHDRIQRLRQEFQQAKQDEDVEDRRRTYSFEQPWPNARPATQSGRHSVSVE 1200
VDSNRSTPSNHDRIQRLRQEFQQAKQDEDVEDRRRTYSFEQPWPNARPATQSGRHSVSVE
Sbjct: 1141 VDSNRSTPSNHDRIQRLRQEFQQAKQDEDVEDRRRTYSFEQPWPNARPATQSGRHSVSVE 1200
Query: 1201 VQMQRQRQEERESSQQAQRQYSSLPRQSRKNASSVSQDSWEQNYSPGEGFQSAKENPRYS 1260
VQMQRQRQEERESSQQAQRQYSSLPRQSRKNASSVSQDSWEQNYSPGEGFQSAKENPRYS
Sbjct: 1201 VQMQRQRQEERESSQQAQRQYSSLPRQSRKNASSVSQDSWEQNYSPGEGFQSAKENPRYS 1260
Query: 1261 SYQGSRNGYLGGHGFNARVMLETQELLRQEQRRKEQQMKKQPPSEGPSNYDSYKKVQDPS 1320
SYQGSRNGYLGGHGFNARVMLETQELLRQEQRRKEQQMKKQPPSEGPSNYDSYKKVQDPS
Sbjct: 1261 SYQGSRNGYLGGHGFNARVMLETQELLRQEQRRKEQQMKKQPPSEGPSNYDSYKKVQDPS 1320
Query: 1321 YAPPKGPFRQDVPPSPSQVARLNRLQTPEKGRPFYS 1356
YAPPKGPFRQDVPPSPSQVARLNRLQTPEKGRPFYS
Sbjct: 1321 YAPPKGPFRQDVPPSPSQVARLNRLQTPEKGRPFYS 1356
>gi|119120907 par-3 partitioning defective 3 homolog B isoform a [Homo
sapiens]
Length = 1104
Score = 536 bits (1382), Expect = e-152
Identities = 413/1147 (36%), Positives = 568/1147 (49%), Gaps = 239/1147 (20%)
Query: 223 SASHPMVGKWLEKQEQDEDGTEEDNSRVEPVGHADTGLEHIPNF--SLDDMVKLVEVPND 280
SASHP G+ L+ D ED E + T L P +L DM + VE+ +
Sbjct: 154 SASHPG-GQSLKLVVPDSTQNLEDR---EVLNGVQTELLTSPRTKDTLSDMTRTVEISGE 209
Query: 281 GGPLGIHVVPF-SARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQ 339
GGPLGIHVVPF S+ GR LGL ++ +E +++ E LF EN+CIV+IN+ DL ++ F Q
Sbjct: 210 GGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQ 269
Query: 340 AQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGL 399
AQ +FRQAM++P + HV+P N+EQYE+ S N + + + +GL
Sbjct: 270 AQDVFRQAMKSPSVLLHVLPPQNREQYEK-SVIGSLNIFGNNDGVLKTKVPPPVHGKSGL 328
Query: 400 HTVQRAPRLNHPPEQIDSHSRLPHSAHPS----GKPPSAPASAPQNVFSTTVSSGYNTKK 455
T A + D+ + L + P G PS+P+ +P G+ + K
Sbjct: 329 KT---ANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPL--------MGFGSNK 377
Query: 456 IGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVN 515
K++ I LKKG EGLGF++ +RD +I G PI+VKNILP+GAAI+DGRL++GDR++EVN
Sbjct: 378 NAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVN 437
Query: 516 GVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDED 575
G D+ G++QEE+V++LRSTK T SL++ RQE F PREL EP + ET
Sbjct: 438 GRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETS----- 492
Query: 576 IVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGR 635
E LTFE+PLNDSGSAGLGVS+KGN+S+E DLGIF+KSII+GGAA KDGR
Sbjct: 493 ---------EQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGR 543
Query: 636 LRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695
LR+NDQLIAVNGESLLGK+N +AMETLRRSMS EGN RGMIQL++ RR
Sbjct: 544 LRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRR------------ 591
Query: 696 PPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNA-ALSRIMGESGKYQLSPTVNMP 754
PE P+E + S + + + RN ++ +G + +P
Sbjct: 592 ---PERPMEDPAECGA--FSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLP 646
Query: 755 QDDTVIIEDDRLPVLPPHLSDQSSSSSHDDVGFVTADAGTWAKAAISDSADCSLSPDVDP 814
D E +PP S + H +G D S S VD
Sbjct: 647 NDGWAESE------VPP------SPTPHSALGL--------------GLEDYSHSSGVDS 680
Query: 815 VLAFQREGFGRQSMSEKRTKQFSDASQLDFVKTRKSKSMDLGIADETKLNTVDDQKAGSP 874
+ F + +S++ R Q + + + SKSMDL + DE+K++++ QK+ SP
Sbjct: 681 AVYFPDQHINFRSVTPAR--------QPESINLKASKSMDL-VPDESKVHSLAGQKSESP 731
Query: 875 SRDVGPSLGLKKSSSLESLQTAVAEVTLNGDIPFHRPRPRIIRGRGCNESFRAAIDKSYD 934
S+D GP+LGLKKSSSLESLQTAVAEV N D+PFHRPRP ++RGRGCNESFRAAIDKSYD
Sbjct: 732 SKDFGPTLGLKKSSSLESLQTAVAEVRKN-DLPFHRPRPHMVRGRGCNESFRAAIDKSYD 790
Query: 935 KPAVDDDDEGMETLEEDTEESSRSGRESVSTASDQPSHSLERQMNGNQEKGDKTDRKKDK 994
P EE G S+ S Q + + E GN E +D
Sbjct: 791 GP----------------EEIEADGLSDKSSHSGQGALNCESAPQGNSEL-------EDM 827
Query: 995 TGKEKKKDRDKEKDKMKAKKGMLKGLGDMFRFGKHRKDDKIEKTGKIKIQESFTSEEERI 1054
K +K + KEK+K K K GK+K++E EE
Sbjct: 828 ENKARKVKKTKEKEKKKEK-------------------------GKLKVKEKKRKEEN-- 860
Query: 1055 RMKQEQERIQAKTREFRERQARERDYAEIQDFHRTFGCDDELMYGGVSSYEGSMALNARP 1114
E ER+ +++ + + F + +D+ GG + +G++
Sbjct: 861 --------------EDPERKIKKKGFGAMLRFGKKK--EDK---GGKAEQKGTL------ 895
Query: 1115 QSPREGHMMDALYAQVKKPRNSKPSPVDSNRSTPSNHDRIQRLRQEFQQAKQD-----ED 1169
+ G + + ++K+ R +S R T + DRIQ+LR+E+ QA+++ ED
Sbjct: 896 ---KHGGLREEELEKMKEER-------ESGRPTGGSTDRIQKLRKEYYQARREGFPLYED 945
Query: 1170 VEDRRRTYSFEQPWPNARPATQSGRHSVSVEVQMQRQRQEERESSQQAQRQYSSLPRQSR 1229
E R R ++ W R H++ E +RQY+SLPR
Sbjct: 946 DEGRARPSEYDLLWVPGR-GPDGNAHNLRFEGM---------------ERQYASLPRGGP 989
Query: 1230 KNASSVSQDSWEQNYSPG--EGFQSAKENPRYSSYQGSRNGYLGGHGFNA-RVMLETQEL 1286
+ +Y P G +E P Y G H + +
Sbjct: 990 ADPV---------DYLPAAPRGLYKERELPYYP----------GAHPMHPPKGSYPRPTE 1030
Query: 1287 LRQEQRRKEQQMKKQPPSEGPSNYDSYKKVQDPSYAPPKGPFRQDVPPSPSQVARLNRLQ 1346
LR R Q PP P + KGPFRQDVPPSP Q R+ Q
Sbjct: 1031 LRVADLRYPQHY---PPPPAPQH---------------KGPFRQDVPPSPPQHQRMPAYQ 1072
Query: 1347 TPEKGRP 1353
E GRP
Sbjct: 1073 --ETGRP 1077
Score = 156 bits (395), Expect = 1e-37
Identities = 78/146 (53%), Positives = 102/146 (69%), Gaps = 3/146 (2%)
Query: 1 MKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWIQVHRLEHGDGGILD 60
MKVTVCFGRT +VVPC +G ++V L QQA+ RY K K P YW+++H LE+ DGGILD
Sbjct: 1 MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD 60
Query: 61 LDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQ 120
DD+L DV +DKD+L+AVF+EQ+P H + S + QSP+ F +E+ ++AF+P
Sbjct: 61 PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAA-QLAAFKP-- 117
Query: 121 ATSEIEVTPSVLRANMPLHVRRSSDP 146
EIEVTPS L+ PL VRRSSDP
Sbjct: 118 IGGEIEVTPSALKLGTPLLVRRSSDP 143
>gi|119120903 par-3 partitioning defective 3 homolog B isoform c [Homo
sapiens]
Length = 1136
Score = 459 bits (1180), Expect = e-128
Identities = 394/1169 (33%), Positives = 551/1169 (47%), Gaps = 251/1169 (21%)
Query: 223 SASHPMVGKWLEKQEQDEDGTEEDNSRVEPVGHADTGLEHIPNF--SLDDMVKLVEVPND 280
SASHP G+ L+ D ED E + T L P +L DM + VE+ +
Sbjct: 154 SASHPG-GQSLKLVVPDSTQNLEDR---EVLNGVQTELLTSPRTKDTLSDMTRTVEISGE 209
Query: 281 GGPLGIHVVPF-SARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQ 339
GGPLGIHVVPF S+ GR LGL ++ +E +++ E LF EN+CIV+IN+ DL ++ F Q
Sbjct: 210 GGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQ 269
Query: 340 AQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGL 399
AQ +FRQAM++P + HV+P N+EQYE+ S N + + + +GL
Sbjct: 270 AQDVFRQAMKSPSVLLHVLPPQNREQYEK-SVIGSLNIFGNNDGVLKTKVPPPVHGKSGL 328
Query: 400 HTVQRAPRLNHPPEQIDSHSRLPHSAHPS----GKPPSAPASAPQNVFSTTVSSGYNTKK 455
T A + D+ + L + P G PS+P+ +P G+ + K
Sbjct: 329 KT---ANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPL--------MGFGSNK 377
Query: 456 IGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVN 515
K++ I LKKG EGLGF++ +RD +I G PI+VKNILP+GAAI+DGRL++GDR++EVN
Sbjct: 378 NAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVN 437
Query: 516 GVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDED 575
G D+ G++QEE+V++LRSTK T SL++ RQE F PREL EP + ET
Sbjct: 438 GRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETS----- 492
Query: 576 IVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGR 635
E LTFE+PLNDSGSAGLGVS+KGN+S+E DLGIF+KSII+GGAA KDGR
Sbjct: 493 ---------EQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGR 543
Query: 636 LRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695
LR+NDQLIAVNGESLLGK+N +AMETLRRSMS EGN RGMIQL++ RR
Sbjct: 544 LRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRR------------ 591
Query: 696 PPGPELPIETALDDRERRISHSLYSGIEGLDESPSRN-AALSRIMGESGKYQLSPTVNMP 754
PE P+E + S + + + RN ++ +G + +P
Sbjct: 592 ---PERPMEDPAEC--GAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLP 646
Query: 755 QDDTVIIEDDRLPVLPPHLSDQSSSSSHDDVGFVTADAGTWAKAAISDSADCSLSPDVDP 814
D E +PP S + H +G D S S VD
Sbjct: 647 NDGWAESE------VPP------SPTPHSALGL--------------GLEDYSHSSGVDS 680
Query: 815 VLAFQREGFGRQSMSEKRTKQFSDASQLDFVKTRKSKSMDLGIADETKLNTVDDQKAGSP 874
+ F + +S++ R Q + + + SKSMDL + DE+K++++ QK
Sbjct: 681 AVYFPDQHINFRSVTPAR--------QPESINLKASKSMDL-VPDESKVHSLAGQK---- 727
Query: 875 SRDVGPSLGLKKSSSLESLQTAVAEVTLNGDIPFHRPRPRIIRGRGCNESFRAAIDKSYD 934
S GL SS S + A++
Sbjct: 728 ------SDGLSDKSS---------------------------------HSGQGALN---- 744
Query: 935 KPAVDDDDEGMETLEEDTEESSRSGRESVSTASDQPSHSLERQMNGNQEKGDKTDRKKDK 994
+ +G L ED E +R +++ + L+ + +E+ + +RK K
Sbjct: 745 ---CESAPQGNSEL-EDMENKARKVKKTKEKEKKKEKGKLKVKEKKRKEENEDPERKIKK 800
Query: 995 TGKEKKKDRDKEKDKMKAKKGMLKGLGDMFRFGKHRKD--DKIEKTGKIKIQESFTSEEE 1052
KG G M RFGK ++D K E+ G +K EEE
Sbjct: 801 -----------------------KGFGAMLRFGKKKEDKGGKAEQKGTLK--HGGLREEE 835
Query: 1053 RIRMKQEQERIQAKTREFRERQARE-RDYAEIQDFHRTFGCDDELM---YGGVSSY-EGS 1107
+MK+E+ERI AK +E RE+QAR DYA + DD+ M Y V+ + E
Sbjct: 836 LEKMKEERERIGAKHQELREKQARGLLDYA-TGAIGSVYDMDDDEMDPNYARVNHFREPC 894
Query: 1108 MALN-----ARPQS-----PREGH-------MMDALYAQVKKPRNSKPSPVDSNRSTPSN 1150
+ N + P++ PR+GH ++ LYA+V KP + P DS R T +
Sbjct: 895 TSANVFRSPSPPRAGPFGYPRDGHPLSPERDHLEGLYAKVNKPYHPL-VPADSGRPTGGS 953
Query: 1151 HDRIQRLRQEFQQAKQD-----EDVEDRRRTYSFEQPWPNARPATQSGRHSVSVEVQMQR 1205
DRIQ+LR+E+ QA+++ ED E R R ++ W R H++ E
Sbjct: 954 TDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGR-GPDGNAHNLRFE----- 1007
Query: 1206 QRQEERESSQQAQRQYSSLPRQSRKNASSVSQDSWEQNYSPGEGFQSAKENPRYSSYQGS 1265
+RQY+SLPR D + + G +E P Y
Sbjct: 1008 ----------GMERQYASLPRGG-------PADPVDYLPAAPRGLYKERELPYYP----- 1045
Query: 1266 RNGYLGGHGFN-ARVMLETQELLRQEQRRKEQQMKKQPPSEGPSNYDSYKKVQDPSYAPP 1324
G H + + LR R Q PP P +
Sbjct: 1046 -----GAHPMHPPKGSYPRPTELRVADLRYPQH---YPPPPAPQH--------------- 1082
Query: 1325 KGPFRQDVPPSPSQVARLNRLQTPEKGRP 1353
KGPFRQDVPPSP Q R+ Q E GRP
Sbjct: 1083 KGPFRQDVPPSPPQHQRMPAYQ--ETGRP 1109
Score = 156 bits (395), Expect = 1e-37
Identities = 78/146 (53%), Positives = 102/146 (69%), Gaps = 3/146 (2%)
Query: 1 MKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWIQVHRLEHGDGGILD 60
MKVTVCFGRT +VVPC +G ++V L QQA+ RY K K P YW+++H LE+ DGGILD
Sbjct: 1 MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD 60
Query: 61 LDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQ 120
DD+L DV +DKD+L+AVF+EQ+P H + S + QSP+ F +E+ ++AF+P
Sbjct: 61 PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAA-QLAAFKP-- 117
Query: 121 ATSEIEVTPSVLRANMPLHVRRSSDP 146
EIEVTPS L+ PL VRRSSDP
Sbjct: 118 IGGEIEVTPSALKLGTPLLVRRSSDP 143
>gi|119120897 par-3 partitioning defective 3 homolog B isoform b [Homo
sapiens]
Length = 1143
Score = 301 bits (770), Expect = 4e-81
Identities = 269/760 (35%), Positives = 364/760 (47%), Gaps = 161/760 (21%)
Query: 633 DGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKS 692
DGRLR+NDQLIAVNGESLLGK+N +AMETLRRSMS EGN RGMIQL++ RR
Sbjct: 479 DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRR--------- 529
Query: 693 PGSPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNA-ALSRIMGESGKYQLSPTV 751
PE P+E + S + + + RN ++ +G +
Sbjct: 530 ------PERPMEDPAECGA--FSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGL 581
Query: 752 NMPQDDTVIIEDDRLPVLPPHLSDQSSSSSHDDVGFVTADAGTWAKAAISDSADCSLSPD 811
+P D E +PP S + H +G D S S
Sbjct: 582 LLPNDGWAESE------VPP------SPTPHSALGL--------------GLEDYSHSSG 615
Query: 812 VDPVLAFQREGFGRQSMSEKRTKQFSDASQLDFVKTRKSKSMDLGIADETKLNTVDDQKA 871
VD + F + +S++ R Q + + + SKSMDL + DE+K++++ QK+
Sbjct: 616 VDSAVYFPDQHINFRSVTPAR--------QPESINLKASKSMDL-VPDESKVHSLAGQKS 666
Query: 872 GSPSRDVGPSLGLKKSSSLESLQTAVAEVTLNGDIPFHRPRPRIIRGRGCNESFRAAIDK 931
SPS+D GP+LGLKKSSSLESLQTAVAEV N D+PFHRPRP ++RGRGCNESFRAAIDK
Sbjct: 667 ESPSKDFGPTLGLKKSSSLESLQTAVAEVRKN-DLPFHRPRPHMVRGRGCNESFRAAIDK 725
Query: 932 SYDKPAVDDDDEGMETLEED--TEESSRSGRESVSTASDQPSHSLERQMNGNQEKGDKT- 988
SYD P E +E D +++SS SG+ +++ S +S M K KT
Sbjct: 726 SYDGP---------EEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTK 776
Query: 989 --DRKKDK---TGKEKKKDRDKEKDKMKAKKGMLKGLGDMFRFGKHRKD--DKIEKTGKI 1041
++KK+K KEKK+ + E + K KK KG G M RFGK ++D K E+ G +
Sbjct: 777 EKEKKKEKGKLKVKEKKRKEENEDPERKIKK---KGFGAMLRFGKKKEDKGGKAEQKGTL 833
Query: 1042 KIQESFTSEEERIRMKQEQERIQAKTREFRERQARE-RDYAEIQDFHRTFGCDDELM--- 1097
K EEE +MK+E+ERI AK +E RE+QAR DYA + DD+ M
Sbjct: 834 K--HGGLREEELEKMKEERERIGAKHQELREKQARGLLDYA-TGAIGSVYDMDDDEMDPN 890
Query: 1098 YGGVSSY-EGSMALN-----ARPQS-----PREGH-------MMDALYAQVKKPRNSKPS 1139
Y V+ + E + N + P++ PR+GH ++ LYA+V KP +
Sbjct: 891 YARVNHFREPCTSANVFRSPSPPRAGPFGYPRDGHPLSPERDHLEGLYAKVNKPYHPL-V 949
Query: 1140 PVDSNRSTPSNHDRIQRLRQEFQQAKQD-----EDVEDRRRTYSFEQPWPNARPATQSGR 1194
P DS R T + DRIQ+LR+E+ QA+++ ED E R R ++ W R
Sbjct: 950 PADSGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGR-GPDGNA 1008
Query: 1195 HSVSVEVQMQRQRQEERESSQQAQRQYSSLPRQSRKNASSVSQDSWEQNYSPGEGFQSAK 1254
H++ E +RQY+SLPR D + + G +
Sbjct: 1009 HNLRFE---------------GMERQYASLPRGG-------PADPVDYLPAAPRGLYKER 1046
Query: 1255 ENPRYSSYQGSRNGYLGGHGFN-ARVMLETQELLRQEQRRKEQQMKKQPPSEGPSNYDSY 1313
E P Y G H + + LR R Q PP P +
Sbjct: 1047 ELPYYP----------GAHPMHPPKGSYPRPTELRVADLRYPQH---YPPPPAPQH---- 1089
Query: 1314 KKVQDPSYAPPKGPFRQDVPPSPSQVARLNRLQTPEKGRP 1353
KGPFRQDVPPSP Q R+ Q E GRP
Sbjct: 1090 -----------KGPFRQDVPPSPPQHQRMPAYQ--ETGRP 1116
Score = 234 bits (596), Expect = 5e-61
Identities = 143/342 (41%), Positives = 204/342 (59%), Gaps = 23/342 (6%)
Query: 223 SASHPMVGKWLEKQEQDEDGTEEDNSRVEPVGHADTGLEHIPNF--SLDDMVKLVEVPND 280
SASHP G+ L+ D ED E + T L P +L DM + VE+ +
Sbjct: 154 SASHPG-GQSLKLVVPDSTQNLEDR---EVLNGVQTELLTSPRTKDTLSDMTRTVEISGE 209
Query: 281 GGPLGIHVVPF-SARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQ 339
GGPLGIHVVPF S+ GR LGL ++ +E +++ E LF EN+CIV+IN+ DL ++ F Q
Sbjct: 210 GGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQ 269
Query: 340 AQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGL 399
AQ +FRQAM++P + HV+P N+EQYE+ S N + + + +GL
Sbjct: 270 AQDVFRQAMKSPSVLLHVLPPQNREQYEK-SVIGSLNIFGNNDGVLKTKVPPPVHGKSGL 328
Query: 400 HTVQRAPRLNHPPEQIDSHSRLPHSAHPS----GKPPSAPASAPQNVFSTTVSSGYNTKK 455
T A + D+ + L + P G PS+P+ +P G+ + K
Sbjct: 329 KT---ANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPL--------MGFGSNK 377
Query: 456 IGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVN 515
K++ I LKKG EGLGF++ +RD +I G PI+VKNILP+GAAI+DGRL++GDR++EVN
Sbjct: 378 NAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVN 437
Query: 516 GVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELN 557
G D+ G++QEE+V++LRSTK T SL++ RQE F PREL+
Sbjct: 438 GRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELD 479
Score = 156 bits (395), Expect = 1e-37
Identities = 78/146 (53%), Positives = 102/146 (69%), Gaps = 3/146 (2%)
Query: 1 MKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWIQVHRLEHGDGGILD 60
MKVTVCFGRT +VVPC +G ++V L QQA+ RY K K P YW+++H LE+ DGGILD
Sbjct: 1 MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD 60
Query: 61 LDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQ 120
DD+L DV +DKD+L+AVF+EQ+P H + S + QSP+ F +E+ ++AF+P
Sbjct: 61 PDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAA-QLAAFKP-- 117
Query: 121 ATSEIEVTPSVLRANMPLHVRRSSDP 146
EIEVTPS L+ PL VRRSSDP
Sbjct: 118 IGGEIEVTPSALKLGTPLLVRRSSDP 143
Score = 38.5 bits (88), Expect = 0.044
Identities = 32/132 (24%), Positives = 62/132 (46%), Gaps = 13/132 (9%)
Query: 547 QEDAFHPRELNAEPSQMQIPKETK-AEDEDIV-------LTPDGTREFLT-FEVPLNDSG 597
Q A HP + ++ +P T+ ED +++ LT T++ L+ + SG
Sbjct: 152 QPSASHP---GGQSLKLVVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMTRTVEISG 208
Query: 598 SAG-LGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQ 656
G LG+ V S + LG+F++ I + + ++G N+ ++ +N L+ KT
Sbjct: 209 EGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFA 268
Query: 657 DAMETLRRSMST 668
A + R++M +
Sbjct: 269 QAQDVFRQAMKS 280
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 114 bits (286), Expect = 5e-25
Identities = 113/423 (26%), Positives = 180/423 (42%), Gaps = 67/423 (15%)
Query: 284 LGIHVVPFSARGGRTL------GLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRF 337
LGI +V G R G+ +K + + A + D IV ++ DLR+
Sbjct: 1162 LGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASH 1221
Query: 338 EQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSA 397
EQA R+A P++ F V N+ + L N Y FS + + D+ +N+
Sbjct: 1222 EQAVEAIRKA-GNPVV-FMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINA- 1278
Query: 398 GLHTVQRAPRLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSS-------- 449
+ P Q +S P A PP P++ + T SS
Sbjct: 1279 -----------DKAPSQSESE---PEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDV 1324
Query: 450 ------GYNTKKIGKRLN--------IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILP 495
GY+ K I +R I+L+KG GLG S+ S +++ I P
Sbjct: 1325 DKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRMS--VFIVGIDP 1382
Query: 496 RGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRE 555
GAA +DGRL+ D L+E+NG L G+S + S+++ + V ++ R +DA +
Sbjct: 1383 NGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSK--VKIIFIRNKDAVNQMA 1440
Query: 556 L---NA-EPSQMQIPKETKAEDEDIVLTPDGTREFLTF------EVPLNDSGSAGLGVSV 605
+ NA EP E E V T D + +F E+P D G G+ +S
Sbjct: 1441 VCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELP-KDQGGLGIAISE 1499
Query: 606 KGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 665
+ S G+ +KS+ G A+ DGRL+V DQ++AV+ E ++G + + L+ +
Sbjct: 1500 EDTLS-------GVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTA 1552
Query: 666 MST 668
T
Sbjct: 1553 KMT 1555
Score = 106 bits (265), Expect = 1e-22
Identities = 103/399 (25%), Positives = 163/399 (40%), Gaps = 89/399 (22%)
Query: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
V+ +E+P D G LGI + + G+++K L + G A + + D I+ ++D
Sbjct: 1481 VQHLELPKDQGGLGIAI----SEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEI 1536
Query: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
+ E+ + + A T + H +PDSQ + +
Sbjct: 1537 VVGYPIEKFISLLKTAKMTVKLTIHAE------------------------NPDSQAVPS 1572
Query: 392 RSVNSAGLHTVQR----APRLNHP-PEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTT 446
+ ++G P+ P PE I + SR A + P + P
Sbjct: 1573 AAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIP-------- 1624
Query: 447 VSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLK 506
G I++ KG GLG SI T+ G+ I + + GAA +DGRL
Sbjct: 1625 ----------GCETTIEISKGRTGLGLSIVGGSDTLLGA--IIIHEVYEEGAACKDGRLW 1672
Query: 507 AGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIP 566
AGD+++EVNG+DL + +E +++LR T V L ++R E +
Sbjct: 1673 AGDQILEVNGIDLRKATHDEAINVLRQTPQR--VRLTLYRDEAPY--------------- 1715
Query: 567 KETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIIN 626
KE + D T + L GLG+S+ G R+ D G+FV I+
Sbjct: 1716 KEEEVCD--------------TLTIELQKKPGKGLGLSIVGKRN-----DTGVFVSDIVK 1756
Query: 627 GGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 665
GG A DGRL DQ++ VNGE + T + L+ S
Sbjct: 1757 GGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVS 1795
Score = 104 bits (260), Expect = 5e-22
Identities = 79/228 (34%), Positives = 113/228 (49%), Gaps = 16/228 (7%)
Query: 444 STTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAP-IYVKNILPRGAAIQD 502
++T+S+ N I+L GLGF I IGG A + VK ILP G A Q
Sbjct: 240 ASTISAHSNPVHWQHMETIELVNDGSGLGFGI------IGGKATGVIVKTILPGGVADQH 293
Query: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQ--EDAFHPRELNAEP 560
GRL +GD ++++ DL G S E+V +LR + V L++ R E+ P L
Sbjct: 294 GRLCSGDHILKIGDTDLAGMSSEQVAQVLR--QCGNRVKLMIARGAIEERTAPTALGITL 351
Query: 561 SQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIF 620
S T + + + E TF+V L + GLG+++ G + GIF
Sbjct: 352 SS----SPTSTPELRVDASTQKGEESETFDVELTKNVQ-GLGITIAGYIGDKKLEPSGIF 406
Query: 621 VKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMST 668
VKSI A DGR+++ DQ+IAV+G +L G TNQ A+E LR + T
Sbjct: 407 VKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQT 454
Score = 101 bits (252), Expect = 4e-21
Identities = 104/417 (24%), Positives = 183/417 (43%), Gaps = 35/417 (8%)
Query: 275 VEVPNDGGPLGIHVVPFSARGGRTL--GLLVKRLEKGGKAEHENLFRENDCIVRINDGDL 332
+E+ LG+ +V G TL +++ + + G A + D I+ +N DL
Sbjct: 1630 IEISKGRTGLGLSIVG----GSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDL 1685
Query: 333 RNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYE----------------QLSQSEKNN 376
R ++A ++ RQ + + + A KE+ LS K N
Sbjct: 1686 RKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRN 1745
Query: 377 ----YYSSRFSPDSQYIDNRSVNSAGLHTVQRAPRLNHPPEQIDSHSRLPHSAHPSGKPP 432
+ S D R + + V N E + + ++ + S P
Sbjct: 1746 DTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSLSSFTFP 1805
Query: 433 SAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKG-TEGLGFSITSRDVTIGGSAPIYVK 491
+ +S +++ S++ + ++ G R +++KKG T+ LG SI + G PI++
Sbjct: 1806 LSGSSTSESLESSSKKNALASEIQGLR-TVEMKKGPTDSLGISIAGGVGSPLGDVPIFIA 1864
Query: 492 NILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAF 551
+ P G A Q +L+ GDR++ + G G + + V+LL++ G++ + V D
Sbjct: 1865 MMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNAS--GSIEMQVVAGGDVS 1922
Query: 552 HPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSK 611
EP+ + T I G + + + + G GLG S+ G
Sbjct: 1923 VVTGHQQEPASSSL-SFTGLTSSSIFQDDLGPPQCKSITL---ERGPDGLGFSIVGGYGS 1978
Query: 612 ENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMST 668
H DL I+VK++ GAAS+DGRL+ DQ+IAVNG+SL G T+++A+ L+R+ T
Sbjct: 1979 P-HGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGT 2034
Score = 85.5 bits (210), Expect = 3e-16
Identities = 120/529 (22%), Positives = 217/529 (41%), Gaps = 64/529 (12%)
Query: 300 GLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVP 359
G+ VK + K EH+ + D I+ ++ +L+ +QA + R +T ++ ++
Sbjct: 404 GIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLT--LMR 461
Query: 360 AANKEQYEQLSQSEKNNYYSSRFSPDSQYI--DNRSVNSAGLHTVQRAPRLNHPPEQIDS 417
K++ E +S+ + + SP + I +N + L + + L E
Sbjct: 462 RGMKQEAELMSREDVTK--DADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPL 519
Query: 418 HSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITS 477
S + K +A + Q + G N + + ++ K +E G I S
Sbjct: 520 LSAEIEEIEDAQKQEAALLTKWQRIM------GINYEIVVAHVS----KFSENSGLGI-S 568
Query: 478 RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKME 537
+ T+G +++++LP G G+L +GD L+EVNG+ L+G++ ++VV++L+ +E
Sbjct: 569 LEATVGHH---FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIE 625
Query: 538 -------GTVSLLVFRQEDAFH--PRELNAEPSQMQIPKETKAEDEDIVLT-PDGTREFL 587
TV + D+ EL +P +E ED VL D +
Sbjct: 626 VTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSETEDPVLAMTDAGQSTE 685
Query: 588 TFEVPLN-----------DSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRL 636
+ PL + GS GLG S+ + + A I ++S++ GG A KDGRL
Sbjct: 686 EVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRL 745
Query: 637 RVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSP 696
D+L+ VN +L + ++A+E L+ G G +++ VA+ + P
Sbjct: 746 LPGDRLMFVNDVNLENSSLEEAVEALK------GAPSGTVRIGVAKPL-----------P 788
Query: 697 PGPELPIETALDDRERRISHSLYSGIEGLDESPSRNAALSRIMGESGKYQLSPTVNMPQD 756
PE +A +D HS GL + P A L+ + T P
Sbjct: 789 LSPEEGYVSAKEDSFLYPPHSCEEA--GLADKPLFRADLALVGTNDADLVDESTFESPYS 846
Query: 757 DTVIIEDDRLPVLPPHLSDQSSSSSHDDVGFVTADAGTWAKAAISDSAD 805
E+D + + SS D + + ++ + K I +S D
Sbjct: 847 P----ENDSIYSTQASILSLHGSSCGDGLNYGSSLPSSPPKDVIENSCD 891
Score = 84.3 bits (207), Expect = 7e-16
Identities = 115/502 (22%), Positives = 203/502 (40%), Gaps = 114/502 (22%)
Query: 263 IPNFSLDDMVKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFREND 322
+ N S + + + + LG+ V + LG++V+ + GG + D
Sbjct: 997 LQNVSKESFERTINIAKGNSSLGMTV----SANKDGLGMIVRSIIHGGAISRDGRIAIGD 1052
Query: 323 CIVRINDGDLRNRRFEQAQHMFRQ-AMRTPIIWFHVVPAANKEQYE-QLSQSEKNNYYSS 380
CI+ IN+ + QA+ M R+ ++ P I VPA + E+++ L Q
Sbjct: 1053 CILSINEESTISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALD 1112
Query: 381 RFSPDSQYIDNRSVNSAGLHTVQRAPRLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQ 440
FS +T + P L E S L ++A+ + P
Sbjct: 1113 IFSS---------------YTGRDIPELPEREEGEGEESELQNTAYSNWNQPRRVEL--- 1154
Query: 441 NVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAI 500
++ K L I + G G+G +++ +V G I++K++L A
Sbjct: 1155 ------------WREPSKSLGISIVGG-RGMGSRLSNGEVMRG----IFIKHVLEDSPAG 1197
Query: 501 QDGRLKAGDRLIEVNGVDLVGKSQEE---------------VVSLLRSTKMEGTVSLLV- 544
++G LK GDR++EV+G+DL S E+ V S++ + SLL
Sbjct: 1198 KNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHN 1257
Query: 545 ------FRQEDAFHPR-ELNAE--PSQMQIPKE----------------------TKAED 573
F + F ++NA+ PSQ + E T++
Sbjct: 1258 LYPKYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSA 1317
Query: 574 EDIVLTPDGTREF-------------LTFEVPLND--SGSAGLGVSVKGNRSKENHADLG 618
I D EF LT E+ + + G +GLG+S+ GN+ + +
Sbjct: 1318 SKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSR---MS 1374
Query: 619 IFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQL 678
+F+ I GAA KDGRL++ D+L+ +NG+ L G+++Q+A ++ + S +++
Sbjct: 1375 VFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPS-------KVKI 1427
Query: 679 IVARRISKCNELK-SPGSPPGP 699
I R N++ PG+ P
Sbjct: 1428 IFIRNKDAVNQMAVCPGNAVEP 1449
Score = 81.6 bits (200), Expect = 5e-15
Identities = 63/241 (26%), Positives = 104/241 (43%), Gaps = 27/241 (11%)
Query: 445 TTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGR 504
TT + + +++L K GLG +I+ D G + +K++ G A DGR
Sbjct: 1467 TTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSG----VIIKSLTEHGVAATDGR 1522
Query: 505 LKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQ-- 562
LK GD+++ V+ +VG E+ +SLL++ KM +++ + P A +
Sbjct: 1523 LKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKK 1582
Query: 563 -----MQIPKETKAEDEDIVLTPDGTREFLTFEVPLN-------------DSGSAGLGVS 604
+ +P+ E E I T + + P G GLG+S
Sbjct: 1583 NSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLS 1642
Query: 605 VKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRR 664
+ G A I + + GAA KDGRL DQ++ VNG L T+ +A+ LR+
Sbjct: 1643 IVGGSDTLLGA---IIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQ 1699
Query: 665 S 665
+
Sbjct: 1700 T 1700
Score = 79.7 bits (195), Expect = 2e-14
Identities = 42/84 (50%), Positives = 58/84 (69%), Gaps = 2/84 (2%)
Query: 461 NIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
+I L++G +GLGFSI + G PIYVK + +GAA +DGRLK GD++I VNG L
Sbjct: 1958 SITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLE 2017
Query: 521 GKSQEEVVSLLRSTKMEGTVSLLV 544
G + EE V++L+ TK GTV+L+V
Sbjct: 2018 GVTHEEAVAILKRTK--GTVTLMV 2039
Score = 73.2 bits (178), Expect = 2e-12
Identities = 71/273 (26%), Positives = 119/273 (43%), Gaps = 47/273 (17%)
Query: 433 SAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITS--RDVTIGGSAPIYV 490
S+P S P+ + G ++ +++L K +GLG +I D + S I+V
Sbjct: 353 SSPTSTPELRVDASTQKGEESETF----DVELTKNVQGLGITIAGYIGDKKLEPSG-IFV 407
Query: 491 KNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLL--VFRQE 548
K+I A DGR++ GD++I V+G +L G + ++ V +LR T ++L+ +QE
Sbjct: 408 KSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQE 467
Query: 549 DAFHPRE-----LNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFE----------VPL 593
RE + P I KE +DED + + T T E +
Sbjct: 468 AELMSREDVTKDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEI 527
Query: 594 NDSGSAGLGVSVKGNR-------------SK-ENHADLGI---------FVKSIINGGAA 630
D+ + K R SK ++ LGI F++S++ G
Sbjct: 528 EDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPV 587
Query: 631 SKDGRLRVNDQLIAVNGESLLGKTNQDAMETLR 663
G+L D+L+ VNG +LLG+ +QD + L+
Sbjct: 588 GHSGKLFSGDELLEVNGITLLGENHQDVVNILK 620
Score = 67.4 bits (163), Expect = 9e-11
Identities = 67/280 (23%), Positives = 110/280 (39%), Gaps = 51/280 (18%)
Query: 464 LKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNG------- 516
LK + GLGFS+ G I+V+ I A +DGRLK D+++ +NG
Sbjct: 141 LKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTI 200
Query: 517 -----VDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKA 571
+ ++ K+++ V ++ + VS +V R A ++ P Q
Sbjct: 201 THQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQ------- 253
Query: 572 EDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAAS 631
E I L DG +GLG + G ++ G+ VK+I+ GG A
Sbjct: 254 HMETIELVNDG----------------SGLGFGIIGGKA------TGVIVKTILPGGVAD 291
Query: 632 KDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNK------RGMIQLIVARRIS 685
+ GRL D ++ + L G +++ + LR+ GN+ RG I+ A
Sbjct: 292 QHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQC----GNRVKLMIARGAIEERTAPTAL 347
Query: 686 KCNELKSPGSPPGPELPIETALDDRERRISHSLYSGIEGL 725
SP S P + T + L ++GL
Sbjct: 348 GITLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQGL 387
Score = 63.5 bits (153), Expect = 1e-09
Identities = 62/288 (21%), Positives = 124/288 (43%), Gaps = 42/288 (14%)
Query: 409 NHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSG------YNTKKIGKRLNI 462
+H P ++ S + LP S P SA + + ++++ N K I
Sbjct: 955 SHLPSEVISSAELP-----SVLPDSAGKGSEYLLEQSSLACNAECVMLQNVSKESFERTI 1009
Query: 463 QLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
+ KG LG ++++ +G + V++I+ GA +DGR+ GD ++ +N +
Sbjct: 1010 NIAKGNSSLGMTVSANKDGLG----MIVRSIIHGGAISRDGRIAIGDCILSINEESTISV 1065
Query: 523 SQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQM------------------- 563
+ + ++LR + G + + A H E Q
Sbjct: 1066 TNAQARAMLRRHSLIGPDIKITY--VPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIP 1123
Query: 564 QIPKETKAEDEDIVLTPDGTREF-LTFEVPLNDSGSAGLGVSVKGNR---SKENHADL-- 617
++P+ + E E+ L + V L S LG+S+ G R S+ ++ ++
Sbjct: 1124 ELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMR 1183
Query: 618 GIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 665
GIF+K ++ A K+G L+ D+++ V+G L +++ A+E +R++
Sbjct: 1184 GIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKA 1231
Score = 44.7 bits (104), Expect = 6e-04
Identities = 24/75 (32%), Positives = 38/75 (50%), Gaps = 5/75 (6%)
Query: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
++ +E+ NDG LG ++ GG+ G++VK + GG A+ D I++I D D
Sbjct: 255 METIELVNDGSGLGFGII-----GGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTD 309
Query: 332 LRNRRFEQAQHMFRQ 346
L EQ + RQ
Sbjct: 310 LAGMSSEQVAQVLRQ 324
Score = 32.0 bits (71), Expect = 4.1
Identities = 17/59 (28%), Positives = 32/59 (54%), Gaps = 2/59 (3%)
Query: 270 DMVKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRIN 328
++ +L++ P+ G LG VV + LG+ V+ +++G A + +E D I+ IN
Sbjct: 136 EVFELLKPPSGG--LGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAIN 192
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 107 bits (267), Expect = 8e-23
Identities = 111/425 (26%), Positives = 179/425 (42%), Gaps = 66/425 (15%)
Query: 274 LVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGDLR 333
++E+ D LG+ + R + + V + G A + R D ++ IN+ L
Sbjct: 1239 IIELEKDKNGLGLSLAGNKDRS--RMSIFVVGINPEGPAAADGRMRIGDELLEINNQILY 1296
Query: 334 NRRFEQAQHMFRQA-MRTPIIWFHVVPAANK---EQYEQLSQSEKNNYYSSRFSPDSQYI 389
R + A + + A + +++ A N+ + S S + S P S
Sbjct: 1297 GRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSEE 1356
Query: 390 DNRSVNSAGLHTVQRAPRLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNV------- 442
D G+ + + Q+ + S + P APAS+ +
Sbjct: 1357 DGSV--EVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGY 1414
Query: 443 --FSTTVSSGYNTKKI--GKRLNIQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRG 497
F +S T I G+ + I++ KG GLG SI +D + I + + G
Sbjct: 1415 GGFQAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLNA---IVIHEVYEEG 1471
Query: 498 AAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELN 557
AA +DGRL AGD+++EVNGVDL S EE ++ LR T + V L+V+R E A + E N
Sbjct: 1472 AAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQK--VRLVVYRDE-AHYRDEEN 1528
Query: 558 AEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADL 617
E F V L GLG+S+ G R+
Sbjct: 1529 LE----------------------------IFPVDLQKKAGRGLGLSIVGKRNGS----- 1555
Query: 618 GIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQ 677
G+F+ I+ GGAA DGRL DQ+++VNGE + +Q+ + T+ + +G++Q
Sbjct: 1556 GVFISDIVKGGAADLDGRLIQGDQILSVNGED-MRNASQETVATILKC------AQGLVQ 1608
Query: 678 LIVAR 682
L + R
Sbjct: 1609 LEIGR 1613
Score = 93.2 bits (230), Expect = 2e-18
Identities = 84/298 (28%), Positives = 137/298 (45%), Gaps = 29/298 (9%)
Query: 408 LNHPP--EQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKI-----GKRL 460
+NH P + I + +G A P + S+T SS +T G
Sbjct: 188 INHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVCWGHVE 247
Query: 461 NIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
++L GLGF I G ++ + V+ I+P G A +DGRL+ GD ++++ G ++
Sbjct: 248 EVELINDGSGLGFGIVG-----GKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQ 302
Query: 521 GKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTP 580
G + E+V +LR+ +V +LV R + A P+ + + T A
Sbjct: 303 GMTSEQVAQVLRNCG--NSVRMLVAR-DPAGDISVTPPAPAALPVALPTVASKGP----G 355
Query: 581 DGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADL-GIFVKSIINGGAASKDGRLRVN 639
+ F T+ V L LG+ + G + + GI+VKSII G AA +G ++VN
Sbjct: 356 SDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVN 415
Query: 640 DQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPP 697
D+++AV+G ++ G N D +E LR N ++ L + RR K + SP PP
Sbjct: 416 DKIVAVDGVNIQGFANHDVVEVLR-------NAGQVVHLTLVRR--KTSSSTSPLEPP 464
Score = 77.4 bits (189), Expect = 9e-14
Identities = 90/387 (23%), Positives = 157/387 (40%), Gaps = 72/387 (18%)
Query: 488 IYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST---------KMEG 538
I++K +L A + LK GD+++EV+GVDL S E V +++ +
Sbjct: 1102 IFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSS 1161
Query: 539 TVSLLV-----------FRQEDAFHPRE--LNAEPSQMQIPKETKA--------EDEDIV 577
T ++ + +D +E P M++P KA E+ED
Sbjct: 1162 TPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDAF 1221
Query: 578 LTPDGTREFLTFEVPLN----DSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKD 633
+ + L+ + GLG+S+ GN+ + + IFV I G A+ D
Sbjct: 1222 TDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSR---MSIFVVGINPEGPAAAD 1278
Query: 634 GRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNEL--- 690
GR+R+ D+L+ +N + L G+++Q+A ++ + S ++L+ R N++
Sbjct: 1279 GRMRIGDELLEINNQILYGRSHQNASAIIKTAPS-------KVKLVFIRNEDAVNQMAVT 1331
Query: 691 --KSPGSPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNAALSRIMGESGKYQLS 748
P S P + ++ + S+ GI+ L ES S A+S++ K Q
Sbjct: 1332 PFPVPSSSPS-SIEDQSGTEPISSEEDGSVEVGIKQLPESESFKLAVSQM-----KQQKY 1385
Query: 749 PTVNMPQDDTVIIEDDRLPVLPPHLSDQSSSSSHDDVGFVTADAGTWAKAAISDSADCSL 808
PT V +P+ P +SS H T G A ++ D A C +
Sbjct: 1386 PT-------KVSFSSQEIPLAP-------ASSYHSTDADFTGYGGFQAPLSV-DPATCPI 1430
Query: 809 SPDVDPVLAFQ--REGFGRQSMSEKRT 833
P + ++ R G G + K T
Sbjct: 1431 VPGQEMIIEISKGRSGLGLSIVGGKDT 1457
Score = 76.6 bits (187), Expect = 1e-13
Identities = 60/219 (27%), Positives = 105/219 (47%), Gaps = 32/219 (14%)
Query: 465 KKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDL-VGKS 523
+ T GLGFS+ + G I+VK++ P A +D RLK D+++ +N L S
Sbjct: 139 RPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNIS 198
Query: 524 QEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGT 583
++ ++LL+ T G++ L+V R EP + + D + P+
Sbjct: 199 HQQAIALLQQT--TGSLRLIVAR------------EPVHTKSSTSSSLNDTTL---PETV 241
Query: 584 REFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLI 643
EV L + GS GLG + G ++ G+ V++I+ GG A +DGRL+ D ++
Sbjct: 242 CWGHVEEVELINDGS-GLGFGIVGGKTS------GVVVRTIVPGGLADRDGRLQTGDHIL 294
Query: 644 AVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVAR 682
+ G ++ G T++ + LR N ++++VAR
Sbjct: 295 KIGGTNVQGMTSEQVAQVLR-------NCGNSVRMLVAR 326
Score = 72.8 bits (177), Expect = 2e-12
Identities = 62/240 (25%), Positives = 107/240 (44%), Gaps = 31/240 (12%)
Query: 465 KKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQ 524
KK GLG SI + G +++ +I+ GAA DGRL GD+++ VNG D+ SQ
Sbjct: 1538 KKAGRGLGLSIVGKRNGSG----VFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQ 1593
Query: 525 EEVVSLLRSTKMEGTVSLLVFRQE----DAFHPRELNAEPSQMQIPKETKAEDEDIVL-- 578
E V ++L+ +G V L + R + N++ SQ ++
Sbjct: 1594 ETVATILKCA--QGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGL 1651
Query: 579 ----------TPDGTREFLTFE---VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSII 625
P E V +N S LG+S+ G R D+ +F+ I
Sbjct: 1652 QNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPL-GDIPVFIAMIQ 1710
Query: 626 NGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRIS 685
G A++ +L+V D+++++NG+ L G ++ D + L+ + R ++Q++ IS
Sbjct: 1711 ASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYG-----RIILQVVADTNIS 1765
Score = 65.1 bits (157), Expect = 4e-10
Identities = 96/446 (21%), Positives = 172/446 (38%), Gaps = 43/446 (9%)
Query: 267 SLDDMVKLVEVPNDGGPLGIHVVPF--SARGGRTLGLLVKRLEKGGKAEHENLFRENDCI 324
SL + + V DG LGI +V + ++ G G+ VK + G A H + ND I
Sbjct: 359 SLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKI 418
Query: 325 VRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSP 384
V ++ +++ + R A + ++ +V L P
Sbjct: 419 VAVDGVNIQGFANHDVVEVLRNAGQ--VVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKP 476
Query: 385 DSQYIDNR-----SVNSAGLHTVQRAPRL-NHPPEQIDSHSRLPHSAHPSGKPPSAPASA 438
+ ++ +V+ +R L N + ++ ++P S K
Sbjct: 477 PALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLG 536
Query: 439 PQN-----VFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNI 493
P T ++ +K K L I T LG + S D Y+ +I
Sbjct: 537 PDYEVMVATLDTQIADDAELQKYSKLLPIH----TLRLGVEVDSFD------GHHYISSI 586
Query: 494 LPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTV---SLLVFRQEDA 550
+ G G L+ D L+EVNG+ L GKS+ E VS L+ T+ L +
Sbjct: 587 VSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASV 646
Query: 551 FHPR--ELNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLND--SGSAGLGVSVK 606
PR E + +++ + E++D DG + EV + + GLG S+
Sbjct: 647 DEPRRTETSLPETEVDHNMDVNTEEDD-----DGELALWSPEVKIVELVKDCKGLGFSIL 701
Query: 607 GNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSM 666
+ + I ++S++ G A + G L D+L++VN L + +A+E L+
Sbjct: 702 DYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILK--- 758
Query: 667 STEGNKRGMIQLIVARRISKCNELKS 692
G++ L + + + + NE +S
Sbjct: 759 ---AVPPGLVHLGICKPLVEDNEEES 781
Score = 55.5 bits (132), Expect = 3e-07
Identities = 64/257 (24%), Positives = 101/257 (39%), Gaps = 52/257 (20%)
Query: 281 GGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQA 340
G LG+ +V R G G+ + + KGG A+ + + D I+ +N D+RN E
Sbjct: 1541 GRGLGLSIV--GKRNGS--GVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETV 1596
Query: 341 QHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLH 400
+ + A + L Q E AG
Sbjct: 1597 ATILKCA-------------------QGLVQLEIGRL------------------RAGSW 1619
Query: 401 TVQRAPRLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRL 460
T R N Q +HS S HPS P + QN+ T S + K G +
Sbjct: 1620 TSARTTSQNSQGSQQSAHS----SCHPSFAPV---ITGLQNLVGTKRVSDPSQKNSGTDM 1672
Query: 461 NIQL----KKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNG 516
+ ++ ++ LG SI + G P+++ I G A + +LK GDR++ +NG
Sbjct: 1673 EPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSING 1732
Query: 517 VDLVGKSQEEVVSLLRS 533
L G S +VV+LL++
Sbjct: 1733 QPLDGLSHADVVNLLKN 1749
Score = 40.8 bits (94), Expect = 0.009
Identities = 23/74 (31%), Positives = 40/74 (54%), Gaps = 5/74 (6%)
Query: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
V+ VE+ NDG LG +V GG+T G++V+ + GG A+ + + D I++I +
Sbjct: 246 VEEVELINDGSGLGFGIV-----GGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTN 300
Query: 332 LRNRRFEQAQHMFR 345
++ EQ + R
Sbjct: 301 VQGMTSEQVAQVLR 314
Score = 39.7 bits (91), Expect = 0.020
Identities = 25/107 (23%), Positives = 51/107 (47%), Gaps = 8/107 (7%)
Query: 564 QIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGN-----RSKENHADLG 618
++P+ + E E+ TP+ + V + + LG+S+ G R K G
Sbjct: 1045 ELPEREEGEGEE---TPNFSHWGPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKG 1101
Query: 619 IFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 665
IF+K ++ A K L+ D+++ V+G L ++ +A+E ++ +
Sbjct: 1102 IFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNA 1148
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 94.7 bits (234), Expect = 5e-19
Identities = 120/521 (23%), Positives = 209/521 (40%), Gaps = 73/521 (14%)
Query: 362 NKEQYEQLSQSEKNNYYSSRF-----------SPDSQYIDNRSVNSAGLHTVQ---RAPR 407
++ + LSQS+ N +++S SP I + + Q + P
Sbjct: 1058 SRTESASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPG 1117
Query: 408 LNHPPEQID-SHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNT-----KKIGKRLN 461
++ + D S + + + S + P + +T+ + T K G
Sbjct: 1118 ISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFE 1177
Query: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
++L K LG S+T T IYVK ++P+GAA DGR+ GDR++ VNGV L G
Sbjct: 1178 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1237
Query: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRE---------LNAEPSQMQIPKETKAE 572
+ ++ V LR+T G V L+ + + +E L+ + +Q Q P++ K
Sbjct: 1238 ATHKQAVETLRNT---GQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKT 1294
Query: 573 DEDIVLTPDGTREFLTFEVPL-NDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAAS 631
+ V E TFEV L +S G S + N E + VK + G A+
Sbjct: 1295 TQ--VKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAA 1352
Query: 632 KDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELK 691
+ G++ V D ++ VNG SL G + Q+ + LR + + L++ R
Sbjct: 1353 ESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPE-------VFLLLCR--------P 1397
Query: 692 SPGSPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNAALSRIMGESGKYQLSPTV 751
PG P + + T L + + +S + S ++ + + +S K SP+
Sbjct: 1398 PPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSR 1457
Query: 752 NMPQDDTVIIEDDRLPVLPPHLSDQS-SSSSHDDVGFVTADAGTWAKAAIS--------- 801
D+ +D L P ++S+ + SS+ H + + + A + +A S
Sbjct: 1458 RDSYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMF 1517
Query: 802 -------------DSADCSLSPDVDPVLAFQREGFGRQSMS 829
DS L PD+ P ++Q + S S
Sbjct: 1518 YYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSS 1558
Score = 51.2 bits (121), Expect = 7e-06
Identities = 30/75 (40%), Positives = 41/75 (54%), Gaps = 1/75 (1%)
Query: 591 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 650
V L GLG + G K DLGIF+ S+ GG A DG L+ D+LI+VN SL
Sbjct: 903 VNLKKDAKYGLGFQIIGGE-KMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSL 961
Query: 651 LGKTNQDAMETLRRS 665
G ++ A+E L+ +
Sbjct: 962 EGVSHHAAIEILQNA 976
Score = 49.7 bits (117), Expect = 2e-05
Identities = 60/208 (28%), Positives = 90/208 (43%), Gaps = 40/208 (19%)
Query: 460 LNIQLKKGTEG-LGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVD 518
L I L K +G LGF++T + IG YV +++ + A DGRLK GDRLI+VN D
Sbjct: 1596 LLITLIKSEKGSLGFTVTKGNQRIG----CYVHDVI-QDPAKSDGRLKPGDRLIKVNDTD 1650
Query: 519 LVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVL 578
+ + + V+LLR+ TV L++ R + P +P L
Sbjct: 1651 VTNMTHTDAVNLLRAASK--TVRLVIGRVLEL---------PRIPMLPH----------L 1689
Query: 579 TPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRV 638
PD T LT LG S+ G +++ I A+ +G L++
Sbjct: 1690 LPDIT---LT-------CNKEELGFSLCGGHDSLYQV---VYISDINPRSVAAIEGNLQL 1736
Query: 639 NDQLIAVNGESLLGKTNQDAMETLRRSM 666
D + VNG S G T ++ L S+
Sbjct: 1737 LDVIHYVNGVSTQGMTLEEVNRALDMSL 1764
Score = 48.5 bits (114), Expect = 4e-05
Identities = 29/80 (36%), Positives = 42/80 (52%), Gaps = 1/80 (1%)
Query: 462 IQLKKGTE-GLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
+ LKK + GLGF I + I++ ++ P G A DG LK GDRLI VN V L
Sbjct: 903 VNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 962
Query: 521 GKSQEEVVSLLRSTKMEGTV 540
G S + +L++ + T+
Sbjct: 963 GVSHHAAIEILQNAPEDVTL 982
Score = 44.3 bits (103), Expect = 8e-04
Identities = 39/132 (29%), Positives = 61/132 (46%), Gaps = 21/132 (15%)
Query: 594 NDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGK 653
++ GS G V+ KGN+ +G +V +I A S DGRL+ D+LI VN +
Sbjct: 1603 SEKGSLGFTVT-KGNQR------IGCYVHDVIQDPAKS-DGRLKPGDRLIKVNDTDVTNM 1654
Query: 654 TNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDRERR 713
T+ DA+ LR + T ++L++ R L+ P P P L + L +
Sbjct: 1655 THTDAVNLLRAASKT-------VRLVIGR------VLELPRIPMLPHLLPDITLTCNKEE 1701
Query: 714 ISHSLYSGIEGL 725
+ SL G + L
Sbjct: 1702 LGFSLCGGHDSL 1713
Score = 36.2 bits (82), Expect = 0.22
Identities = 31/110 (28%), Positives = 52/110 (47%), Gaps = 7/110 (6%)
Query: 461 NIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
+I L E LGFS+ ++ +Y+ +I PR A +G L+ D + VNGV
Sbjct: 1692 DITLTCNKEELGFSLCGGHDSL--YQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQ 1749
Query: 521 GKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETK 570
G + EEV + ++ ++ LV + P +++ S + PK TK
Sbjct: 1750 GMTLEEV-----NRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTK 1794
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 94.7 bits (234), Expect = 5e-19
Identities = 120/521 (23%), Positives = 209/521 (40%), Gaps = 73/521 (14%)
Query: 362 NKEQYEQLSQSEKNNYYSSRF-----------SPDSQYIDNRSVNSAGLHTVQ---RAPR 407
++ + LSQS+ N +++S SP I + + Q + P
Sbjct: 1249 SRTESASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPG 1308
Query: 408 LNHPPEQID-SHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNT-----KKIGKRLN 461
++ + D S + + + S + P + +T+ + T K G
Sbjct: 1309 ISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFE 1368
Query: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
++L K LG S+T T IYVK ++P+GAA DGR+ GDR++ VNGV L G
Sbjct: 1369 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1428
Query: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRE---------LNAEPSQMQIPKETKAE 572
+ ++ V LR+T G V L+ + + +E L+ + +Q Q P++ K
Sbjct: 1429 ATHKQAVETLRNT---GQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKT 1485
Query: 573 DEDIVLTPDGTREFLTFEVPL-NDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAAS 631
+ V E TFEV L +S G S + N E + VK + G A+
Sbjct: 1486 TQ--VKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAA 1543
Query: 632 KDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELK 691
+ G++ V D ++ VNG SL G + Q+ + LR + + L++ R
Sbjct: 1544 ESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPE-------VFLLLCR--------P 1588
Query: 692 SPGSPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNAALSRIMGESGKYQLSPTV 751
PG P + + T L + + +S + S ++ + + +S K SP+
Sbjct: 1589 PPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSR 1648
Query: 752 NMPQDDTVIIEDDRLPVLPPHLSDQS-SSSSHDDVGFVTADAGTWAKAAIS--------- 801
D+ +D L P ++S+ + SS+ H + + + A + +A S
Sbjct: 1649 RDSYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMF 1708
Query: 802 -------------DSADCSLSPDVDPVLAFQREGFGRQSMS 829
DS L PD+ P ++Q + S S
Sbjct: 1709 YYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSS 1749
Score = 51.2 bits (121), Expect = 7e-06
Identities = 30/75 (40%), Positives = 41/75 (54%), Gaps = 1/75 (1%)
Query: 591 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 650
V L GLG + G K DLGIF+ S+ GG A DG L+ D+LI+VN SL
Sbjct: 1094 VNLKKDAKYGLGFQIIGGE-KMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSL 1152
Query: 651 LGKTNQDAMETLRRS 665
G ++ A+E L+ +
Sbjct: 1153 EGVSHHAAIEILQNA 1167
Score = 49.7 bits (117), Expect = 2e-05
Identities = 60/208 (28%), Positives = 90/208 (43%), Gaps = 40/208 (19%)
Query: 460 LNIQLKKGTEG-LGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVD 518
L I L K +G LGF++T + IG YV +++ + A DGRLK GDRLI+VN D
Sbjct: 1787 LLITLIKSEKGSLGFTVTKGNQRIG----CYVHDVI-QDPAKSDGRLKPGDRLIKVNDTD 1841
Query: 519 LVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVL 578
+ + + V+LLR+ TV L++ R + P +P L
Sbjct: 1842 VTNMTHTDAVNLLRAASK--TVRLVIGRVLEL---------PRIPMLPH----------L 1880
Query: 579 TPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRV 638
PD T LT LG S+ G +++ I A+ +G L++
Sbjct: 1881 LPDIT---LT-------CNKEELGFSLCGGHDSLYQV---VYISDINPRSVAAIEGNLQL 1927
Query: 639 NDQLIAVNGESLLGKTNQDAMETLRRSM 666
D + VNG S G T ++ L S+
Sbjct: 1928 LDVIHYVNGVSTQGMTLEEVNRALDMSL 1955
Score = 48.5 bits (114), Expect = 4e-05
Identities = 29/80 (36%), Positives = 42/80 (52%), Gaps = 1/80 (1%)
Query: 462 IQLKKGTE-GLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
+ LKK + GLGF I + I++ ++ P G A DG LK GDRLI VN V L
Sbjct: 1094 VNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 1153
Query: 521 GKSQEEVVSLLRSTKMEGTV 540
G S + +L++ + T+
Sbjct: 1154 GVSHHAAIEILQNAPEDVTL 1173
Score = 44.3 bits (103), Expect = 8e-04
Identities = 39/132 (29%), Positives = 61/132 (46%), Gaps = 21/132 (15%)
Query: 594 NDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGK 653
++ GS G V+ KGN+ +G +V +I A S DGRL+ D+LI VN +
Sbjct: 1794 SEKGSLGFTVT-KGNQR------IGCYVHDVIQDPAKS-DGRLKPGDRLIKVNDTDVTNM 1845
Query: 654 TNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDRERR 713
T+ DA+ LR + T ++L++ R L+ P P P L + L +
Sbjct: 1846 THTDAVNLLRAASKT-------VRLVIGR------VLELPRIPMLPHLLPDITLTCNKEE 1892
Query: 714 ISHSLYSGIEGL 725
+ SL G + L
Sbjct: 1893 LGFSLCGGHDSL 1904
Score = 36.2 bits (82), Expect = 0.22
Identities = 31/110 (28%), Positives = 52/110 (47%), Gaps = 7/110 (6%)
Query: 461 NIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
+I L E LGFS+ ++ +Y+ +I PR A +G L+ D + VNGV
Sbjct: 1883 DITLTCNKEELGFSLCGGHDSL--YQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQ 1940
Query: 521 GKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETK 570
G + EEV + ++ ++ LV + P +++ S + PK TK
Sbjct: 1941 GMTLEEV-----NRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTK 1985
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
2 [Homo sapiens]
Length = 2466
Score = 94.7 bits (234), Expect = 5e-19
Identities = 120/521 (23%), Positives = 209/521 (40%), Gaps = 73/521 (14%)
Query: 362 NKEQYEQLSQSEKNNYYSSRF-----------SPDSQYIDNRSVNSAGLHTVQ---RAPR 407
++ + LSQS+ N +++S SP I + + Q + P
Sbjct: 1230 SRTESASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPG 1289
Query: 408 LNHPPEQID-SHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNT-----KKIGKRLN 461
++ + D S + + + S + P + +T+ + T K G
Sbjct: 1290 ISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFE 1349
Query: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
++L K LG S+T T IYVK ++P+GAA DGR+ GDR++ VNGV L G
Sbjct: 1350 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1409
Query: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRE---------LNAEPSQMQIPKETKAE 572
+ ++ V LR+T G V L+ + + +E L+ + +Q Q P++ K
Sbjct: 1410 ATHKQAVETLRNT---GQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKT 1466
Query: 573 DEDIVLTPDGTREFLTFEVPL-NDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAAS 631
+ V E TFEV L +S G S + N E + VK + G A+
Sbjct: 1467 TQ--VKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAA 1524
Query: 632 KDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELK 691
+ G++ V D ++ VNG SL G + Q+ + LR + + L++ R
Sbjct: 1525 ESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPE-------VFLLLCR--------P 1569
Query: 692 SPGSPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNAALSRIMGESGKYQLSPTV 751
PG P + + T L + + +S + S ++ + + +S K SP+
Sbjct: 1570 PPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSR 1629
Query: 752 NMPQDDTVIIEDDRLPVLPPHLSDQS-SSSSHDDVGFVTADAGTWAKAAIS--------- 801
D+ +D L P ++S+ + SS+ H + + + A + +A S
Sbjct: 1630 RDSYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMF 1689
Query: 802 -------------DSADCSLSPDVDPVLAFQREGFGRQSMS 829
DS L PD+ P ++Q + S S
Sbjct: 1690 YYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSS 1730
Score = 54.3 bits (129), Expect = 8e-07
Identities = 49/158 (31%), Positives = 75/158 (47%), Gaps = 17/158 (10%)
Query: 518 DLVGK-----SQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAE 572
+LVGK S+ + SL TK+ + S+ + R+ ++ S ++ P +
Sbjct: 998 ELVGKPSHQMSRSDAESLAGVTKLNNSKSVASLNRSP--ERRKHESDSSSIEDPGQAYVL 1055
Query: 573 DE-----DIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIING 627
D IV +P+ RE V L GLG + G K DLGIF+ S+ G
Sbjct: 1056 DVLHKRWSIVSSPE--REITL--VNLKKDAKYGLGFQIIGGE-KMGRLDLGIFISSVAPG 1110
Query: 628 GAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 665
G A DG L+ D+LI+VN SL G ++ A+E L+ +
Sbjct: 1111 GPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNA 1148
Score = 49.7 bits (117), Expect = 2e-05
Identities = 60/208 (28%), Positives = 90/208 (43%), Gaps = 40/208 (19%)
Query: 460 LNIQLKKGTEG-LGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVD 518
L I L K +G LGF++T + IG YV +++ + A DGRLK GDRLI+VN D
Sbjct: 1768 LLITLIKSEKGSLGFTVTKGNQRIG----CYVHDVI-QDPAKSDGRLKPGDRLIKVNDTD 1822
Query: 519 LVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVL 578
+ + + V+LLR+ TV L++ R + P +P L
Sbjct: 1823 VTNMTHTDAVNLLRAASK--TVRLVIGRVLEL---------PRIPMLPH----------L 1861
Query: 579 TPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRV 638
PD T LT LG S+ G +++ I A+ +G L++
Sbjct: 1862 LPDIT---LT-------CNKEELGFSLCGGHDSLYQV---VYISDINPRSVAAIEGNLQL 1908
Query: 639 NDQLIAVNGESLLGKTNQDAMETLRRSM 666
D + VNG S G T ++ L S+
Sbjct: 1909 LDVIHYVNGVSTQGMTLEEVNRALDMSL 1936
Score = 48.5 bits (114), Expect = 4e-05
Identities = 29/80 (36%), Positives = 42/80 (52%), Gaps = 1/80 (1%)
Query: 462 IQLKKGTE-GLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
+ LKK + GLGF I + I++ ++ P G A DG LK GDRLI VN V L
Sbjct: 1075 VNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 1134
Query: 521 GKSQEEVVSLLRSTKMEGTV 540
G S + +L++ + T+
Sbjct: 1135 GVSHHAAIEILQNAPEDVTL 1154
Score = 44.3 bits (103), Expect = 8e-04
Identities = 39/132 (29%), Positives = 61/132 (46%), Gaps = 21/132 (15%)
Query: 594 NDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGK 653
++ GS G V+ KGN+ +G +V +I A S DGRL+ D+LI VN +
Sbjct: 1775 SEKGSLGFTVT-KGNQR------IGCYVHDVIQDPAKS-DGRLKPGDRLIKVNDTDVTNM 1826
Query: 654 TNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDRERR 713
T+ DA+ LR + T ++L++ R L+ P P P L + L +
Sbjct: 1827 THTDAVNLLRAASKT-------VRLVIGR------VLELPRIPMLPHLLPDITLTCNKEE 1873
Query: 714 ISHSLYSGIEGL 725
+ SL G + L
Sbjct: 1874 LGFSLCGGHDSL 1885
Score = 36.2 bits (82), Expect = 0.22
Identities = 31/110 (28%), Positives = 52/110 (47%), Gaps = 7/110 (6%)
Query: 461 NIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
+I L E LGFS+ ++ +Y+ +I PR A +G L+ D + VNGV
Sbjct: 1864 DITLTCNKEELGFSLCGGHDSL--YQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQ 1921
Query: 521 GKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETK 570
G + EEV + ++ ++ LV + P +++ S + PK TK
Sbjct: 1922 GMTLEEV-----NRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTK 1966
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 91.7 bits (226), Expect = 4e-18
Identities = 122/529 (23%), Positives = 212/529 (40%), Gaps = 84/529 (15%)
Query: 362 NKEQYEQLSQSEKNNYYSSRF-----------SPDSQYIDNRSVNSAGLHTVQ---RAPR 407
++ + LSQS+ N +++S SP I + + Q + P
Sbjct: 1249 SRTESASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPG 1308
Query: 408 LNHPPEQID-SHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNT-----KKIGKRLN 461
++ + D S + + + S + P + +T+ + T K G
Sbjct: 1309 ISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFE 1368
Query: 462 IQLKKGTEGLGFSIT--------SRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIE 513
++L K LG S+T + V GG IYVK ++P+GAA DGR+ GDR++
Sbjct: 1369 VELAKNDNSLGISVTVLFDKGGVNTSVRHGG---IYVKAVIPQGAAESDGRIHKGDRVLA 1425
Query: 514 VNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRE---------LNAEPSQMQ 564
VNGV L G + ++ V LR+T G V L+ + + +E L+ + +Q Q
Sbjct: 1426 VNGVSLEGATHKQAVETLRNT---GQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQ 1482
Query: 565 IPKETKAEDEDIVLTPDGTREFLTFEVPL-NDSGSAGLGVSVKGNRSKENHADLGIFVKS 623
P++ K + V E TFEV L +S G S + N E + VK
Sbjct: 1483 GPEKVKKTTQ--VKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKK 1540
Query: 624 IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARR 683
+ G A++ G++ V D ++ VNG SL G + Q+ + LR + + L++ R
Sbjct: 1541 LFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPE-------VFLLLCR- 1592
Query: 684 ISKCNELKSPGSPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNAALSRIMGESG 743
PG P + + T L + + +S + S ++ + + +S
Sbjct: 1593 -------PPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSK 1645
Query: 744 KYQLSPTVNMPQDDTVIIEDDRLPVLPPHLSDQS-SSSSHDDVGFVTADAGTWAKAAIS- 801
K SP+ D+ +D L P ++S+ + SS+ H + + + A + +A S
Sbjct: 1646 KQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQ 1705
Query: 802 ---------------------DSADCSLSPDVDPVLAFQREGFGRQSMS 829
DS L PD+ P ++Q + S S
Sbjct: 1706 EDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSS 1754
Score = 51.2 bits (121), Expect = 7e-06
Identities = 30/75 (40%), Positives = 41/75 (54%), Gaps = 1/75 (1%)
Query: 591 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 650
V L GLG + G K DLGIF+ S+ GG A DG L+ D+LI+VN SL
Sbjct: 1094 VNLKKDAKYGLGFQIIGGE-KMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSL 1152
Query: 651 LGKTNQDAMETLRRS 665
G ++ A+E L+ +
Sbjct: 1153 EGVSHHAAIEILQNA 1167
Score = 49.7 bits (117), Expect = 2e-05
Identities = 60/208 (28%), Positives = 90/208 (43%), Gaps = 40/208 (19%)
Query: 460 LNIQLKKGTEG-LGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVD 518
L I L K +G LGF++T + IG YV +++ + A DGRLK GDRLI+VN D
Sbjct: 1792 LLITLIKSEKGSLGFTVTKGNQRIG----CYVHDVI-QDPAKSDGRLKPGDRLIKVNDTD 1846
Query: 519 LVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVL 578
+ + + V+LLR+ TV L++ R + P +P L
Sbjct: 1847 VTNMTHTDAVNLLRAASK--TVRLVIGRVLEL---------PRIPMLPH----------L 1885
Query: 579 TPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRV 638
PD T LT LG S+ G +++ I A+ +G L++
Sbjct: 1886 LPDIT---LT-------CNKEELGFSLCGGHDSLYQV---VYISDINPRSVAAIEGNLQL 1932
Query: 639 NDQLIAVNGESLLGKTNQDAMETLRRSM 666
D + VNG S G T ++ L S+
Sbjct: 1933 LDVIHYVNGVSTQGMTLEEVNRALDMSL 1960
Score = 48.5 bits (114), Expect = 4e-05
Identities = 29/80 (36%), Positives = 42/80 (52%), Gaps = 1/80 (1%)
Query: 462 IQLKKGTE-GLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
+ LKK + GLGF I + I++ ++ P G A DG LK GDRLI VN V L
Sbjct: 1094 VNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 1153
Query: 521 GKSQEEVVSLLRSTKMEGTV 540
G S + +L++ + T+
Sbjct: 1154 GVSHHAAIEILQNAPEDVTL 1173
Score = 44.3 bits (103), Expect = 8e-04
Identities = 39/132 (29%), Positives = 61/132 (46%), Gaps = 21/132 (15%)
Query: 594 NDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGK 653
++ GS G V+ KGN+ +G +V +I A S DGRL+ D+LI VN +
Sbjct: 1799 SEKGSLGFTVT-KGNQR------IGCYVHDVIQDPAKS-DGRLKPGDRLIKVNDTDVTNM 1850
Query: 654 TNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDRERR 713
T+ DA+ LR + T ++L++ R L+ P P P L + L +
Sbjct: 1851 THTDAVNLLRAASKT-------VRLVIGR------VLELPRIPMLPHLLPDITLTCNKEE 1897
Query: 714 ISHSLYSGIEGL 725
+ SL G + L
Sbjct: 1898 LGFSLCGGHDSL 1909
Score = 36.2 bits (82), Expect = 0.22
Identities = 31/110 (28%), Positives = 52/110 (47%), Gaps = 7/110 (6%)
Query: 461 NIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
+I L E LGFS+ ++ +Y+ +I PR A +G L+ D + VNGV
Sbjct: 1888 DITLTCNKEELGFSLCGGHDSL--YQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQ 1945
Query: 521 GKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETK 570
G + EEV + ++ ++ LV + P +++ S + PK TK
Sbjct: 1946 GMTLEEV-----NRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTK 1990
>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform c [Homo sapiens]
Length = 1462
Score = 89.4 bits (220), Expect = 2e-17
Identities = 112/451 (24%), Positives = 183/451 (40%), Gaps = 77/451 (17%)
Query: 267 SLDDMVKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVR 326
S+ +L+ V GP+G + GG G VK++ + +E D IV
Sbjct: 634 SIATQPELITVHIVKGPMGFGFTIADSPGGG--GQRVKQIVDSPRCRG---LKEGDLIVE 688
Query: 327 INDGDLRNRRFEQAQHMFRQAMR----TPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRF 382
+N +++ Q M + + T ++ +P K Q + +
Sbjct: 689 VNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERK--------- 739
Query: 383 SPDSQYIDNRSVNS-AGLHTVQRAPRLNHPPEQIDSHSRLPHSAHPSG-KPPSAPASAPQ 440
DSQ SV+S LHT + PE + ++ P SG K P P
Sbjct: 740 --DSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPD-----PF 792
Query: 441 NVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAP---IYVKNILPRG 497
+++ + S N + +I L + G GF I +GG+ P IY+ +I+P G
Sbjct: 793 KIWAQSRSMYENRLPDYQEQDIFLWRKETGFGFRI------LGGNEPGEPIYIGHIVPLG 846
Query: 498 AAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELN 557
AA DGRL++GD LI V+G ++GKS + VV L++ +G V+L V R+ P+ N
Sbjct: 847 AADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTEN 906
Query: 558 AEPSQMQIPKETK--AEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGN------- 608
PS + A + TP G++ L V ++G+G G
Sbjct: 907 EVPSPASSHHSSNQPASLTEEKRTPQGSQNSLN-TVSSGSGSTSGIGSGGGGGSGVVSTV 965
Query: 609 --------RSKENHADLGIFVKS-----------------------IINGGAASKDGRLR 637
R EN + V S II G A + G+L+
Sbjct: 966 VQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLK 1025
Query: 638 VNDQLIAVNGESLLGKTNQDAMETLRRSMST 668
V D+++AVNG S+ K++ D + ++ + +T
Sbjct: 1026 VGDRILAVNGCSITNKSHSDIVNLIKEAGNT 1056
Score = 76.6 bits (187), Expect = 1e-13
Identities = 75/291 (25%), Positives = 133/291 (45%), Gaps = 59/291 (20%)
Query: 422 PHSAHPSGKPPSA------PASAPQNVFSTTVSSGYNTKKIG--------------KRLN 461
P S+H S P++ QN +T S +T IG + +
Sbjct: 911 PASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYD 970
Query: 462 IQLKKG-TEGLGFSITSR------DVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRL 511
+++++G EG GF I S T G + P + I+ A + G+LK GDR+
Sbjct: 971 VEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRI 1030
Query: 512 IEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPREL-NAE----------P 560
+ VNG + KS ++V+L++ + TV+L + +++ + L NAE P
Sbjct: 1031 LAVNGCSITNKSHSDIVNLIK--EAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTP 1088
Query: 561 SQMQIPKET------KAEDEDIVLTPDGTRE--FLTFEVPLNDSGSAGLGVSVKGNRSKE 612
SQ Q +ET K E + P T+E F T E+ + G+ G G S++G R
Sbjct: 1089 SQ-QGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVEL---ERGAKGFGFSLRGGR--- 1141
Query: 613 NHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLR 663
++ ++V + G A + G++R+ D+++ +NGE+ + A+E ++
Sbjct: 1142 -EYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIK 1191
Score = 61.6 bits (148), Expect = 5e-09
Identities = 124/549 (22%), Positives = 197/549 (35%), Gaps = 139/549 (25%)
Query: 234 EKQEQDEDGTEEDNSRVEPVGHADTGLEHIPNFSLDDMVKLVEVPNDGGPL--------- 284
++Q+Q E+ TE+ ++ V PV IPN + EVP G P
Sbjct: 417 QQQQQTEEWTEDHSALVPPV---------IPNHPPSNPEPAREVPLQGKPFFTRNPSELK 467
Query: 285 GIHVVPFSARGGRTLG------------LLVKRLEKGGKAEHENLFRENDCIVRINDGDL 332
G + + R G L +K L G A + D IV +ND +
Sbjct: 468 GKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCV 527
Query: 333 RNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNR 392
Q +F+ +P E Y F PD +
Sbjct: 528 LGHTHAQVVKIFQS-----------IPIGASVDLELCRG------YPLPFDPDDP--NTS 568
Query: 393 SVNSAGLHTVQRAPRLNHPPEQIDSHSRLPHSAHPSGKP-------PSAPASAPQNVF-- 443
V S + + + P + + E DS + HS+ +GK PS+PA N
Sbjct: 569 LVTSVAI--LDKEPIIVNGQETYDSPAS--HSSK-TGKVNGMKDARPSSPADVASNSSHG 623
Query: 444 --STTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQ 501
+ TVS + + + + + KG G GF+I G V + RG
Sbjct: 624 YPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRG---- 679
Query: 502 DGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFR--------------- 546
LK GD ++EVN ++ + +VV +L V+LLV R
Sbjct: 680 ---LKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPL 736
Query: 547 ---------QEDAFHPRELNAE-------------PSQMQIPKETKAEDEDIVLTPDGTR 584
Q R L+ P++ Q P +T + + PD +
Sbjct: 737 ERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQK---KPDPFK 793
Query: 585 EFLT----FEVPLND---------SGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAAS 631
+ +E L D G G + G N I++ I+ GAA
Sbjct: 794 IWAQSRSMYENRLPDYQEQDIFLWRKETGFGFRILGG----NEPGEPIYIGHIVPLGAAD 849
Query: 632 KDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRI-----SK 686
DGRLR D+LI V+G ++GK++Q ++ ++++ K+G + L V R++
Sbjct: 850 TDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAA-----KQGHVNLTVRRKVVFAVPKT 904
Query: 687 CNELKSPGS 695
NE+ SP S
Sbjct: 905 ENEVPSPAS 913
Score = 53.5 bits (127), Expect = 1e-06
Identities = 38/148 (25%), Positives = 72/148 (48%), Gaps = 11/148 (7%)
Query: 403 QRAPRLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKI-GKRLN 461
Q+ + E + HS L P+ PPS P A + N ++ GK ++
Sbjct: 414 QQQQQQQQTEEWTEDHSALVPPVIPN-HPPSNPEPAREVPLQGKPFFTRNPSELKGKFIH 472
Query: 462 IQLKKGTEGLGFSITSRDVTIGGSAP---IYVKNILPRGAAIQDGRLKAGDRLIEVNGVD 518
+L+K + G GF++ +GG P + +K+++ G A DG+++ GD ++ VN
Sbjct: 473 TKLRKSSRGFGFTV------VGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTC 526
Query: 519 LVGKSQEEVVSLLRSTKMEGTVSLLVFR 546
++G + +VV + +S + +V L + R
Sbjct: 527 VLGHTHAQVVKIFQSIPIGASVDLELCR 554
Score = 39.3 bits (90), Expect = 0.026
Identities = 39/234 (16%), Positives = 87/234 (37%), Gaps = 53/234 (22%)
Query: 303 VKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPAAN 362
+ R+ +G A+ + D I+ +N + N+ ++ ++A T + ++P
Sbjct: 1009 IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNT--VTLRIIPGDE 1066
Query: 363 KEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAPRLNHPPEQIDSHSRLP 422
L+ +EK ++ +P Q Q P ++ + P
Sbjct: 1067 SSNATLLTNAEKIATITTTHTPSQQ-------------GTQETRNTTKPKQESQFEFKAP 1113
Query: 423 HSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTI 482
A+ Q+ ++ ++L++G +G GFS+
Sbjct: 1114 Q------------ATQEQDFYT-----------------VELERGAKGFGFSLR------ 1138
Query: 483 GG---SAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRS 533
GG + +YV + G A + G+++ GD ++E+NG + L+++
Sbjct: 1139 GGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKN 1192
Score = 37.0 bits (84), Expect = 0.13
Identities = 35/154 (22%), Positives = 63/154 (40%), Gaps = 21/154 (13%)
Query: 598 SAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQD 657
S G G +V G + D + +KS++ G A+ DG++ D +++VN +LG T+
Sbjct: 479 SRGFGFTVVGG----DEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQ 534
Query: 658 AMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIET--ALDDRERRIS 715
++ + I + + + C P P P + T A+ D+E I
Sbjct: 535 VVKIFQ-----------SIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPII- 582
Query: 716 HSLYSGIEGLDESPSRNAALSRIMGESGKYQLSP 749
+G E D S ++ ++ G SP
Sbjct: 583 ---VNGQETYDSPASHSSKTGKVNGMKDARPSSP 613
Score = 31.6 bits (70), Expect = 5.4
Identities = 21/76 (27%), Positives = 40/76 (52%), Gaps = 15/76 (19%)
Query: 1281 LETQELLRQEQRRKEQQMKKQPPSEGPSNYDSYKKVQDPSYAPPKGPFRQDVPPSPSQVA 1340
LE Q+ +Q+Q++++QQ ++Q E ++ + PP P + PPS + A
Sbjct: 400 LEQQQQQQQQQQQQQQQQQQQQTEEWTEDHS--------ALVPPVIP---NHPPSNPEPA 448
Query: 1341 RLNRLQTPEKGRPFYS 1356
R + P +G+PF++
Sbjct: 449 R----EVPLQGKPFFT 460
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 88.2 bits (217), Expect = 5e-17
Identities = 88/311 (28%), Positives = 132/311 (42%), Gaps = 58/311 (18%)
Query: 422 PHSAHPSGKPPSAPASAPQNVFSTTVSS-GYNTKKIGKR-----LNIQLKKGTEGLGFSI 475
P H P+ S P V + T+ + GY + G I L++G GLGFSI
Sbjct: 63 PPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSI 122
Query: 476 T--SRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRS 533
+ + IG I++ I+P GAA QDGRL+ D ++ VN VD+ + V L+
Sbjct: 123 AGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALK- 181
Query: 534 TKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPL 593
+ V L V R++ P K + ++
Sbjct: 182 -EAGSIVRLYVMRRK-----------------PPAEKVMEIKLI---------------- 207
Query: 594 NDSGSAGLGVSVKGNRSKEN-HADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLG 652
G GLG S+ G ++ D I+V II GGAA KDGRL++ D+++AVN L
Sbjct: 208 --KGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLED 265
Query: 653 KTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDRER 712
++DA+ L+ N ++ L VA+ + L +PP LD+
Sbjct: 266 VMHEDAVAALK-------NTYDVVYLKVAKPSNA--YLSDSYAPPDITTSYSQHLDN--- 313
Query: 713 RISHSLYSGIE 723
ISHS Y G +
Sbjct: 314 EISHSSYLGTD 324
Score = 88.2 bits (217), Expect = 5e-17
Identities = 108/406 (26%), Positives = 170/406 (41%), Gaps = 82/406 (20%)
Query: 458 KRLNIQLKKGTEGLGFSITSR--DVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVN 515
K + I+L KG +GLGFSI + I G IYV I+ GAA +DGRL+ GD+++ VN
Sbjct: 200 KVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVN 259
Query: 516 GVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQ-----EDAFHPRELNAEPSQMQIPKETK 570
V L E+ V+ L++T V L V + D++ P ++ SQ + E
Sbjct: 260 SVGLEDVMHEDAVAALKNT--YDVVYLKVAKPSNAYLSDSYAPPDITTSYSQ-HLDNEIS 316
Query: 571 -----AEDEDIVLTPDGTREFLTF--------EVP------LNDSGSAGLGVSVKGNRSK 611
D +TP R + ++P + GS GLG ++ G
Sbjct: 317 HSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDG 376
Query: 612 ENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGN 671
E GIF+ I+ GG A G LR DQ+++VNG L +++ A L+ +
Sbjct: 377 E-----GIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNA------ 425
Query: 672 KRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDD-RERRISHSLYSGIEGLDESPS 730
G I+A+ P E + D RE+ ++ SL SG L +P
Sbjct: 426 --GQTVTIIAQ------------YKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPK 471
Query: 731 RNAALSRIMGESGKYQ----LSPTVNMPQDDTVIIEDDRLPVLPPHLSDQS--------S 778
R + R + + K + LS ++ D + + D SD+ S
Sbjct: 472 RGFYI-RALFDYDKTKDCGFLSQALSFRFGDVLHVID---------ASDEEWWQARRVHS 521
Query: 779 SSSHDDVGFVTA----DAGTWAKAAISDSADCSLSPD-VDPVLAFQ 819
S DD+GF+ + + W++ D S S D VL+++
Sbjct: 522 DSETDDIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYE 567
Score = 32.7 bits (73), Expect = 2.4
Identities = 25/89 (28%), Positives = 42/89 (47%), Gaps = 5/89 (5%)
Query: 270 DMVKLVEVPNDGGPLGIHV----VPFSARGGRT-LGLLVKRLEKGGKAEHENLFRENDCI 324
D++ ++P + + IH + F+ GG G+ + + GG A+ R+ D I
Sbjct: 343 DLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQI 402
Query: 325 VRINDGDLRNRRFEQAQHMFRQAMRTPII 353
+ +N DLRN EQA + A +T I
Sbjct: 403 LSVNGVDLRNASHEQAAIALKNAGQTVTI 431
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 88.2 bits (217), Expect = 5e-17
Identities = 88/308 (28%), Positives = 132/308 (42%), Gaps = 55/308 (17%)
Query: 422 PHSAHPSGKPPSAPASAPQNVFSTTVSS-GYNTKKIGKRL--NIQLKKGTEGLGFSIT-- 476
P H P+ S P V + T+ + GY G+ I L++G GLGFSI
Sbjct: 20 PPLEHSPAHLPNQANSPPVIVNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGFSIAGG 79
Query: 477 SRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKM 536
+ + IG I++ I+P GAA QDGRL+ D ++ VN VD+ + V L+ +
Sbjct: 80 TDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALK--EA 137
Query: 537 EGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDS 596
V L V R++ P K + ++
Sbjct: 138 GSIVRLYVMRRK-----------------PPAEKVMEIKLI------------------K 162
Query: 597 GSAGLGVSVKGNRSKEN-HADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTN 655
G GLG S+ G ++ D I+V II GGAA KDGRL++ D+++AVN L +
Sbjct: 163 GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMH 222
Query: 656 QDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDRERRIS 715
+DA+ L+ N ++ L VA+ + L +PP LD+ IS
Sbjct: 223 EDAVAALK-------NTYDVVYLKVAKPSNA--YLSDSYAPPDITTSYSQHLDN---EIS 270
Query: 716 HSLYSGIE 723
HS Y G +
Sbjct: 271 HSSYLGTD 278
Score = 88.2 bits (217), Expect = 5e-17
Identities = 108/406 (26%), Positives = 170/406 (41%), Gaps = 82/406 (20%)
Query: 458 KRLNIQLKKGTEGLGFSITSR--DVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVN 515
K + I+L KG +GLGFSI + I G IYV I+ GAA +DGRL+ GD+++ VN
Sbjct: 154 KVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVN 213
Query: 516 GVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQ-----EDAFHPRELNAEPSQMQIPKETK 570
V L E+ V+ L++T V L V + D++ P ++ SQ + E
Sbjct: 214 SVGLEDVMHEDAVAALKNT--YDVVYLKVAKPSNAYLSDSYAPPDITTSYSQ-HLDNEIS 270
Query: 571 -----AEDEDIVLTPDGTREFLTF--------EVP------LNDSGSAGLGVSVKGNRSK 611
D +TP R + ++P + GS GLG ++ G
Sbjct: 271 HSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDG 330
Query: 612 ENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGN 671
E GIF+ I+ GG A G LR DQ+++VNG L +++ A L+ +
Sbjct: 331 E-----GIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNA------ 379
Query: 672 KRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDD-RERRISHSLYSGIEGLDESPS 730
G I+A+ P E + D RE+ ++ SL SG L +P
Sbjct: 380 --GQTVTIIAQ------------YKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPK 425
Query: 731 RNAALSRIMGESGKYQ----LSPTVNMPQDDTVIIEDDRLPVLPPHLSDQS--------S 778
R + R + + K + LS ++ D + + D SD+ S
Sbjct: 426 RGFYI-RALFDYDKTKDCGFLSQALSFRFGDVLHVID---------ASDEEWWQARRVHS 475
Query: 779 SSSHDDVGFVTA----DAGTWAKAAISDSADCSLSPD-VDPVLAFQ 819
S DD+GF+ + + W++ D S S D VL+++
Sbjct: 476 DSETDDIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYE 521
Score = 32.7 bits (73), Expect = 2.4
Identities = 25/89 (28%), Positives = 42/89 (47%), Gaps = 5/89 (5%)
Query: 270 DMVKLVEVPNDGGPLGIHV----VPFSARGGRT-LGLLVKRLEKGGKAEHENLFRENDCI 324
D++ ++P + + IH + F+ GG G+ + + GG A+ R+ D I
Sbjct: 297 DLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQI 356
Query: 325 VRINDGDLRNRRFEQAQHMFRQAMRTPII 353
+ +N DLRN EQA + A +T I
Sbjct: 357 LSVNGVDLRNASHEQAAIALKNAGQTVTI 385
>gi|218505835 membrane-associated guanylate kinase-related 3
isoform 1 [Homo sapiens]
Length = 1481
Score = 86.3 bits (212), Expect = 2e-16
Identities = 62/242 (25%), Positives = 118/242 (48%), Gaps = 9/242 (3%)
Query: 427 PSGKPPS-----APASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVT 481
P PPS +P P V+ + + + K L++ L+K G GF + D
Sbjct: 687 PMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGGD-- 744
Query: 482 IGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVS 541
G IY+ I+P GAA +DGRL+A D L+ ++G+ + GKS ++V+ L+ + G V
Sbjct: 745 -GPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHV- 802
Query: 542 LLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGL 601
LL R++ + ++ + SQ I + + + P ++V L + G
Sbjct: 803 LLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGF 862
Query: 602 GVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMET 661
G + +++K + + +I G A + G+L+V D + AVNG+S++ ++ + ++
Sbjct: 863 GFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQL 922
Query: 662 LR 663
++
Sbjct: 923 IK 924
Score = 68.6 bits (166), Expect = 4e-11
Identities = 63/249 (25%), Positives = 108/249 (43%), Gaps = 51/249 (20%)
Query: 465 KKGTEGLGFSI-TSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKS 523
+K EG GF I TS++ G P + ++ A + G+LK GD + VNG +V S
Sbjct: 856 RKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELS 915
Query: 524 QEEVVSLLRSTKMEGTVSLLV-------------FRQEDAFHPRELNAEPSQMQIPKETK 570
+ +V L++ + T++++ RQ A R + + IP +
Sbjct: 916 HDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQAN-HIPGDRS 974
Query: 571 AEDEDI------------------------VLTPDGTREFLT---FEVPLNDSGSAGLGV 603
A + +I V++ G+R + V L + G G G
Sbjct: 975 ALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVEL-ERGPRGFGF 1033
Query: 604 SVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLR 663
S++G + ++G+F+ + G A KDGR+ V DQ++ +NGE G T+ A+E ++
Sbjct: 1034 SLRGGKEY----NMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQ 1089
Query: 664 RSMSTEGNK 672
GNK
Sbjct: 1090 AG----GNK 1094
Score = 55.1 bits (131), Expect = 5e-07
Identities = 32/93 (34%), Positives = 51/93 (54%), Gaps = 9/93 (9%)
Query: 457 GKRLNIQLKKGTEGLGFSITSRDVTIGGSAP---IYVKNILPRGAAIQDGRLKAGDRLIE 513
G + LKK T G GF+I IGG P + VKN+L G A QDG++ GD +++
Sbjct: 406 GVLVRASLKKSTMGFGFTI------IGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVD 459
Query: 514 VNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFR 546
+NG ++G + +VV + + + V+L + R
Sbjct: 460 INGNCVLGHTHADVVQMFQLVPVNQYVNLTLCR 492
Score = 52.8 bits (125), Expect = 2e-06
Identities = 64/284 (22%), Positives = 116/284 (40%), Gaps = 63/284 (22%)
Query: 437 SAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPR 496
+ P + VS + + + I L KG +G GF+I D G + + + +
Sbjct: 554 NGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIA--DSPTGQKVKMILDSQWCQ 611
Query: 497 GAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFR---------- 546
G L+ GD + E+ ++ + +VV +L+ + V LL+ R
Sbjct: 612 G-------LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTA 664
Query: 547 ------QEDAFHPRELN--------------------AEPSQMQIPKETKAEDEDIVLTP 580
+E+A +N +PS++ + +T ED+ P
Sbjct: 665 KMKTDKKENAGSLEAINEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDK-----P 719
Query: 581 DGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVND 640
T++ F +G G V G + D I++ +II GAA KDGRLR D
Sbjct: 720 PNTKDLDVF----LRKQESGFGFRVLGG----DGPDQSIYIGAIIPLGAAEKDGRLRAAD 771
Query: 641 QLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRI 684
+L+ ++G + GK+++ ++ + T + G + L V R+I
Sbjct: 772 ELMCIDGIPVKGKSHKQVLD-----LMTTAARNGHVLLTVRRKI 810
Score = 45.1 bits (105), Expect = 5e-04
Identities = 20/73 (27%), Positives = 43/73 (58%), Gaps = 5/73 (6%)
Query: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
++L++G G GFS+ ++ +G +++ + G AI+DGR+ GD+++E+NG
Sbjct: 1022 VELERGPRGFGFSLRGGKEYNMG----LFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQ 1077
Query: 521 GKSQEEVVSLLRS 533
G + + L+++
Sbjct: 1078 GITHTRAIELIQA 1090
Score = 37.4 bits (85), Expect = 0.098
Identities = 17/61 (27%), Positives = 35/61 (57%), Gaps = 4/61 (6%)
Query: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
G G ++ G + D + VK+++ G A++DG++ D ++ +NG +LG T+ D +
Sbjct: 419 GFGFTIIGG----DRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVV 474
Query: 660 E 660
+
Sbjct: 475 Q 475
>gi|155969695 membrane-associated guanylate kinase-related 3
isoform 2 [Homo sapiens]
Length = 1125
Score = 86.3 bits (212), Expect = 2e-16
Identities = 62/242 (25%), Positives = 118/242 (48%), Gaps = 9/242 (3%)
Query: 427 PSGKPPS-----APASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVT 481
P PPS +P P V+ + + + K L++ L+K G GF + D
Sbjct: 687 PMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGGD-- 744
Query: 482 IGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVS 541
G IY+ I+P GAA +DGRL+A D L+ ++G+ + GKS ++V+ L+ + G V
Sbjct: 745 -GPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHV- 802
Query: 542 LLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGL 601
LL R++ + ++ + SQ I + + + P ++V L + G
Sbjct: 803 LLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGF 862
Query: 602 GVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMET 661
G + +++K + + +I G A + G+L+V D + AVNG+S++ ++ + ++
Sbjct: 863 GFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQL 922
Query: 662 LR 663
++
Sbjct: 923 IK 924
Score = 68.6 bits (166), Expect = 4e-11
Identities = 63/249 (25%), Positives = 108/249 (43%), Gaps = 51/249 (20%)
Query: 465 KKGTEGLGFSI-TSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKS 523
+K EG GF I TS++ G P + ++ A + G+LK GD + VNG +V S
Sbjct: 856 RKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELS 915
Query: 524 QEEVVSLLRSTKMEGTVSLLV-------------FRQEDAFHPRELNAEPSQMQIPKETK 570
+ +V L++ + T++++ RQ A R + + IP +
Sbjct: 916 HDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQAN-HIPGDRS 974
Query: 571 AEDEDI------------------------VLTPDGTREFLT---FEVPLNDSGSAGLGV 603
A + +I V++ G+R + V L + G G G
Sbjct: 975 ALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVEL-ERGPRGFGF 1033
Query: 604 SVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLR 663
S++G + ++G+F+ + G A KDGR+ V DQ++ +NGE G T+ A+E ++
Sbjct: 1034 SLRGGKEY----NMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQ 1089
Query: 664 RSMSTEGNK 672
GNK
Sbjct: 1090 AG----GNK 1094
Score = 55.1 bits (131), Expect = 5e-07
Identities = 32/93 (34%), Positives = 51/93 (54%), Gaps = 9/93 (9%)
Query: 457 GKRLNIQLKKGTEGLGFSITSRDVTIGGSAP---IYVKNILPRGAAIQDGRLKAGDRLIE 513
G + LKK T G GF+I IGG P + VKN+L G A QDG++ GD +++
Sbjct: 406 GVLVRASLKKSTMGFGFTI------IGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVD 459
Query: 514 VNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFR 546
+NG ++G + +VV + + + V+L + R
Sbjct: 460 INGNCVLGHTHADVVQMFQLVPVNQYVNLTLCR 492
Score = 52.8 bits (125), Expect = 2e-06
Identities = 64/284 (22%), Positives = 116/284 (40%), Gaps = 63/284 (22%)
Query: 437 SAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPR 496
+ P + VS + + + I L KG +G GF+I D G + + + +
Sbjct: 554 NGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIA--DSPTGQKVKMILDSQWCQ 611
Query: 497 GAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFR---------- 546
G L+ GD + E+ ++ + +VV +L+ + V LL+ R
Sbjct: 612 G-------LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTA 664
Query: 547 ------QEDAFHPRELN--------------------AEPSQMQIPKETKAEDEDIVLTP 580
+E+A +N +PS++ + +T ED+ P
Sbjct: 665 KMKTDKKENAGSLEAINEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDK-----P 719
Query: 581 DGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVND 640
T++ F +G G V G + D I++ +II GAA KDGRLR D
Sbjct: 720 PNTKDLDVF----LRKQESGFGFRVLGG----DGPDQSIYIGAIIPLGAAEKDGRLRAAD 771
Query: 641 QLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRI 684
+L+ ++G + GK+++ ++ + T + G + L V R+I
Sbjct: 772 ELMCIDGIPVKGKSHKQVLD-----LMTTAARNGHVLLTVRRKI 810
Score = 45.1 bits (105), Expect = 5e-04
Identities = 20/73 (27%), Positives = 43/73 (58%), Gaps = 5/73 (6%)
Query: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
++L++G G GFS+ ++ +G +++ + G AI+DGR+ GD+++E+NG
Sbjct: 1022 VELERGPRGFGFSLRGGKEYNMG----LFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQ 1077
Query: 521 GKSQEEVVSLLRS 533
G + + L+++
Sbjct: 1078 GITHTRAIELIQA 1090
Score = 37.4 bits (85), Expect = 0.098
Identities = 17/61 (27%), Positives = 35/61 (57%), Gaps = 4/61 (6%)
Query: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
G G ++ G + D + VK+++ G A++DG++ D ++ +NG +LG T+ D +
Sbjct: 419 GFGFTIIGG----DRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVV 474
Query: 660 E 660
+
Sbjct: 475 Q 475
>gi|24025688 ligand of numb-protein X 2 [Homo sapiens]
Length = 690
Score = 86.3 bits (212), Expect = 2e-16
Identities = 95/392 (24%), Positives = 156/392 (39%), Gaps = 72/392 (18%)
Query: 279 NDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFE 338
+ G LGI +V R G+ + L +GG A + ND ++ IN DL+
Sbjct: 346 DSGEQLGIKLV----RRTDEPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLK----- 396
Query: 339 QAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAG 398
TP + ++ A+ + +++ K ++ AG
Sbjct: 397 ---------YGTPELAAQIIQASGERVNLTIARPGKPQ-------------PGNTIREAG 434
Query: 399 LHTVQRAPRLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGK 458
H S S H+ P PS+ Q V T + T K
Sbjct: 435 NH----------------SSSSQHHTPPPYYSRPSSHKDLTQCV---TCQEKHITVK--- 472
Query: 459 RLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVD 518
K+ E LG ++ + G PI+V ++ P G +DGR+K GD L+ +NG+D
Sbjct: 473 ------KEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGID 526
Query: 519 LVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVL 578
L S E V++L+++ V+L + + NAE + P + D
Sbjct: 527 LTNLSHSEAVAMLKASAASPAVALKALEVQIVEEATQ-NAE----EQPSTFSENEYDASW 581
Query: 579 TPD-----GTREFL--TFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAAS 631
+P G L ++ L S G S+ G +ENH + F+K+I+ G A
Sbjct: 582 SPSWVMWLGLPSTLHSCHDIVLRRSYLGSWGFSIVGG-YEENHTNQPFFIKTIVLGTPAY 640
Query: 632 KDGRLRVNDQLIAVNGESLLGKTNQDAMETLR 663
DGRL+ D ++AVNG S +G ++ + L+
Sbjct: 641 YDGRLKCGDMIVAVNGLSTVGMSHSALVPMLK 672
Score = 59.7 bits (143), Expect = 2e-08
Identities = 51/208 (24%), Positives = 99/208 (47%), Gaps = 19/208 (9%)
Query: 469 EGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVV 528
E LG + R G +++ ++L G A QDGRL + DR++ +NG DL + E
Sbjct: 349 EQLGIKLVRRTDEPG----VFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAA 404
Query: 529 SLLRSTKMEGTVSLLVFRQE-----DAFHPRELNAEPSQMQIPK---ETKAEDEDIVLTP 580
+++++ V+L + R + ++ SQ P + +D+
Sbjct: 405 QIIQASGER--VNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCV 462
Query: 581 DGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVND 640
+ +T + ++S LG++V G R ++ +L IFV S+ G ++DGR++ D
Sbjct: 463 TCQEKHITVKKEPHES----LGMTVAGGRGSKS-GELPIFVTSVPPHGCLARDGRIKRGD 517
Query: 641 QLIAVNGESLLGKTNQDAMETLRRSMST 668
L+ +NG L ++ +A+ L+ S ++
Sbjct: 518 VLLNINGIDLTNLSHSEAVAMLKASAAS 545
Score = 55.5 bits (132), Expect = 3e-07
Identities = 56/200 (28%), Positives = 91/200 (45%), Gaps = 39/200 (19%)
Query: 471 LGFSITSRDVTIGGSAP---IYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEV 527
LG SI G P I ++ + G +DGRL AGD++++VN ++ S
Sbjct: 245 LGISIVG-----GNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYA 299
Query: 528 VSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREFL 587
++L ++ T+ L V R E F R N S P+E
Sbjct: 300 RAVL--SQPCNTLHLTVLR-ERRFGNRAHNHSDSNS--PREE------------------ 336
Query: 588 TFEVPLN--DSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAV 645
F+V L+ DSG LG+ + + G+F+ ++ GG A++DGRL ND+++A+
Sbjct: 337 IFQVALHKRDSGEQ-LGIKLVRRTDEP-----GVFILDLLEGGLAAQDGRLSSNDRVLAI 390
Query: 646 NGESLLGKTNQDAMETLRRS 665
NG L T + A + ++ S
Sbjct: 391 NGHDLKYGTPELAAQIIQAS 410
Score = 47.0 bits (110), Expect = 1e-04
Identities = 24/72 (33%), Positives = 40/72 (55%)
Query: 472 GFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLL 531
GFSI + P ++K I+ A DGRLK GD ++ VNG+ VG S +V +L
Sbjct: 612 GFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPML 671
Query: 532 RSTKMEGTVSLL 543
+ + + T++++
Sbjct: 672 KEQRNKVTLTVI 683
Score = 32.3 bits (72), Expect = 3.2
Identities = 17/68 (25%), Positives = 33/68 (48%), Gaps = 3/68 (4%)
Query: 601 LGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAME 660
LG+S+ G + I ++ + G ++DGRL DQ++ VN ++ ++ A
Sbjct: 245 LGISIVGGNETPL---INIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARA 301
Query: 661 TLRRSMST 668
L + +T
Sbjct: 302 VLSQPCNT 309
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 84.0 bits (206), Expect = 9e-16
Identities = 65/207 (31%), Positives = 100/207 (48%), Gaps = 40/207 (19%)
Query: 462 IQLKKGTEGLGFSIT--SRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDL 519
I L++G GLGFSI + + IG I++ I+P GAA +DGRL+ D ++ VN VD+
Sbjct: 48 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 107
Query: 520 VGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLT 579
S + V L K G++ L R+ R + ++++ K
Sbjct: 108 SEVSHSKAVEAL---KEAGSIVRLYVRRR-----RPILETVVEIKLFK------------ 147
Query: 580 PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKEN-HADLGIFVKSIINGGAASKDGRLRV 638
G GLG S+ G ++ D I+V II+GGAA KDGRL+V
Sbjct: 148 -----------------GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQV 190
Query: 639 NDQLIAVNGESLLGKTNQDAMETLRRS 665
D+L+ VN SL T+++A+ L+ +
Sbjct: 191 GDRLLMVNNYSLEEVTHEEAVAILKNT 217
Score = 77.4 bits (189), Expect = 9e-14
Identities = 84/320 (26%), Positives = 131/320 (40%), Gaps = 72/320 (22%)
Query: 460 LNIQLKKGTEGLGFSITSR--DVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGV 517
+ I+L KG +GLGFSI + I G IYV I+ GAA +DGRL+ GDRL+ VN
Sbjct: 141 VEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNY 200
Query: 518 DLVGKSQEEVVSLLRSTKMEGTVSL---LVFRQEDAFHPRELNAEPS------------- 561
L + EE V++L++T + + D + P ++ S
Sbjct: 201 SLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNG 260
Query: 562 ---------------QMQIPKETKAEDEDIVLTPDGT---REFLTFEVPLNDSG------ 597
IPK +D+ + T + +T + ++ G
Sbjct: 261 TLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVV 320
Query: 598 ----SAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGK 653
S GLG ++ G E GIFV I+ GG A G L+ DQ+++VNG L G
Sbjct: 321 LHKGSTGLGFNIVGGEDGE-----GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGA 375
Query: 654 TNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDD-RER 712
+++ A L+ + G I+A+ P E + D RE+
Sbjct: 376 SHEQAAAALKGA--------GQTVTIIAQ------------YQPEDYARFEAKIHDLREQ 415
Query: 713 RISHSLYSGIEGLDESPSRN 732
++HS+ SG L + R+
Sbjct: 416 MMNHSMSSGSGSLRTNQKRS 435
Score = 58.9 bits (141), Expect = 3e-08
Identities = 45/143 (31%), Positives = 72/143 (50%), Gaps = 11/143 (7%)
Query: 581 DGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHAD-LGIFVKSIINGGAASKDGRLRVN 639
+GT FE + G++GLG S+ G + D GIF+ II GGAA++DGRLRVN
Sbjct: 37 NGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVN 96
Query: 640 DQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARR---ISKCNELKSPGSP 696
D ++ VN + ++ A+E L+ + S +++L V RR + E+K P
Sbjct: 97 DCILRVNEVDVSEVSHSKAVEALKEAGS-------IVRLYVRRRRPILETVVEIKLFKGP 149
Query: 697 PGPELPIETALDDRERRISHSLY 719
G I + ++ +S+Y
Sbjct: 150 KGLGFSIAGGVGNQHIPGDNSIY 172
Score = 52.0 bits (123), Expect = 4e-06
Identities = 32/93 (34%), Positives = 50/93 (53%), Gaps = 5/93 (5%)
Query: 457 GKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNG 516
G+ + L KG+ GLGF+I + G I+V IL G A G L+ GD+++ VNG
Sbjct: 314 GEPRKVVLHKGSTGLGFNIVGGEDGEG----IFVSFILAGGPADLSGELQRGDQILSVNG 369
Query: 517 VDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQED 549
+DL G S E+ + L+ T+ + ++ ED
Sbjct: 370 IDLRGASHEQAAAALKGAGQTVTI-IAQYQPED 401
Score = 34.3 bits (77), Expect = 0.83
Identities = 14/48 (29%), Positives = 26/48 (54%)
Query: 300 GLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFRQA 347
G+ + ++ GG A + R NDCI+R+N+ D+ +A ++A
Sbjct: 75 GIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEA 122
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 84.0 bits (206), Expect = 9e-16
Identities = 64/207 (30%), Positives = 100/207 (48%), Gaps = 40/207 (19%)
Query: 462 IQLKKGTEGLGFSIT--SRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDL 519
I L++G GLGFSI + + IG I++ I+P GAA +DGRL+ D ++ VN VD+
Sbjct: 204 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 263
Query: 520 VGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLT 579
S + V L+ G++ L R+ R + ++++ K
Sbjct: 264 SEVSHSKAVEALKEA---GSIVRLYVRRR-----RPILETVVEIKLFK------------ 303
Query: 580 PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKEN-HADLGIFVKSIINGGAASKDGRLRV 638
G GLG S+ G ++ D I+V II+GGAA KDGRL+V
Sbjct: 304 -----------------GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQV 346
Query: 639 NDQLIAVNGESLLGKTNQDAMETLRRS 665
D+L+ VN SL T+++A+ L+ +
Sbjct: 347 GDRLLMVNNYSLEEVTHEEAVAILKNT 373
Score = 61.6 bits (148), Expect = 5e-09
Identities = 51/172 (29%), Positives = 83/172 (48%), Gaps = 15/172 (8%)
Query: 552 HPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSK 611
H L A P+ + + +T D + +GT FE + G++GLG S+ G
Sbjct: 168 HISPLKASPAPIIVNTDTL----DTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDN 223
Query: 612 ENHAD-LGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEG 670
+ D GIF+ II GGAA++DGRLRVND ++ VN + ++ A+E L+ + S
Sbjct: 224 PHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGS--- 280
Query: 671 NKRGMIQLIVARR---ISKCNELKSPGSPPGPELPIETALDDRERRISHSLY 719
+++L V RR + E+K P G I + ++ +S+Y
Sbjct: 281 ----IVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIY 328
Score = 60.1 bits (144), Expect = 1e-08
Identities = 35/77 (45%), Positives = 48/77 (62%), Gaps = 2/77 (2%)
Query: 460 LNIQLKKGTEGLGFSITSR--DVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGV 517
+ I+L KG +GLGFSI + I G IYV I+ GAA +DGRL+ GDRL+ VN
Sbjct: 297 VEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNY 356
Query: 518 DLVGKSQEEVVSLLRST 534
L + EE V++L++T
Sbjct: 357 SLEEVTHEEAVAILKNT 373
Score = 52.4 bits (124), Expect = 3e-06
Identities = 40/129 (31%), Positives = 58/129 (44%), Gaps = 11/129 (8%)
Query: 421 LPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDV 480
LP S S S P VS +K+ L KG+ GLGF+I +
Sbjct: 492 LPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKV------VLHKGSTGLGFNIVGGED 545
Query: 481 TIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTV 540
G I+V IL G A G L+ GD+++ VNG+DL G S E+ + L+ T+
Sbjct: 546 GEG----IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTI 601
Query: 541 SLLVFRQED 549
+ ++ ED
Sbjct: 602 -IAQYQPED 609
Score = 48.5 bits (114), Expect = 4e-05
Identities = 40/137 (29%), Positives = 61/137 (44%), Gaps = 26/137 (18%)
Query: 597 GSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQ 656
GS GLG ++ G E GIFV I+ GG A G L+ DQ+++VNG L G +++
Sbjct: 532 GSTGLGFNIVGGEDGE-----GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHE 586
Query: 657 DAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDD-RERRIS 715
A L+ + G I+A+ P E + D RE+ ++
Sbjct: 587 QAAAALKGA--------GQTVTIIAQ------------YQPEDYARFEAKIHDLREQMMN 626
Query: 716 HSLYSGIEGLDESPSRN 732
HS+ SG L + R+
Sbjct: 627 HSMSSGSGSLRTNQKRS 643
Score = 34.3 bits (77), Expect = 0.83
Identities = 14/48 (29%), Positives = 26/48 (54%)
Query: 300 GLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFRQA 347
G+ + ++ GG A + R NDCI+R+N+ D+ +A ++A
Sbjct: 231 GIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEA 278
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 84.0 bits (206), Expect = 9e-16
Identities = 64/207 (30%), Positives = 100/207 (48%), Gaps = 40/207 (19%)
Query: 462 IQLKKGTEGLGFSIT--SRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDL 519
I L++G GLGFSI + + IG I++ I+P GAA +DGRL+ D ++ VN VD+
Sbjct: 99 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 158
Query: 520 VGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLT 579
S + V L+ G++ L R+ R + ++++ K
Sbjct: 159 SEVSHSKAVEALKEA---GSIVRLYVRRR-----RPILETVVEIKLFK------------ 198
Query: 580 PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKEN-HADLGIFVKSIINGGAASKDGRLRV 638
G GLG S+ G ++ D I+V II+GGAA KDGRL+V
Sbjct: 199 -----------------GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQV 241
Query: 639 NDQLIAVNGESLLGKTNQDAMETLRRS 665
D+L+ VN SL T+++A+ L+ +
Sbjct: 242 GDRLLMVNNYSLEEVTHEEAVAILKNT 268
Score = 61.6 bits (148), Expect = 5e-09
Identities = 51/172 (29%), Positives = 83/172 (48%), Gaps = 15/172 (8%)
Query: 552 HPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSK 611
H L A P+ + + +T D + +GT FE + G++GLG S+ G
Sbjct: 63 HISPLKASPAPIIVNTDTL----DTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDN 118
Query: 612 ENHAD-LGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEG 670
+ D GIF+ II GGAA++DGRLRVND ++ VN + ++ A+E L+ + S
Sbjct: 119 PHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGS--- 175
Query: 671 NKRGMIQLIVARR---ISKCNELKSPGSPPGPELPIETALDDRERRISHSLY 719
+++L V RR + E+K P G I + ++ +S+Y
Sbjct: 176 ----IVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIY 223
Score = 60.1 bits (144), Expect = 1e-08
Identities = 35/77 (45%), Positives = 48/77 (62%), Gaps = 2/77 (2%)
Query: 460 LNIQLKKGTEGLGFSITSR--DVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGV 517
+ I+L KG +GLGFSI + I G IYV I+ GAA +DGRL+ GDRL+ VN
Sbjct: 192 VEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNY 251
Query: 518 DLVGKSQEEVVSLLRST 534
L + EE V++L++T
Sbjct: 252 SLEEVTHEEAVAILKNT 268
Score = 52.4 bits (124), Expect = 3e-06
Identities = 40/129 (31%), Positives = 58/129 (44%), Gaps = 11/129 (8%)
Query: 421 LPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDV 480
LP S S S P VS +K+ L KG+ GLGF+I +
Sbjct: 387 LPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKV------VLHKGSTGLGFNIVGGED 440
Query: 481 TIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTV 540
G I+V IL G A G L+ GD+++ VNG+DL G S E+ + L+ T+
Sbjct: 441 GEG----IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTI 496
Query: 541 SLLVFRQED 549
+ ++ ED
Sbjct: 497 -IAQYQPED 504
Score = 48.5 bits (114), Expect = 4e-05
Identities = 40/137 (29%), Positives = 61/137 (44%), Gaps = 26/137 (18%)
Query: 597 GSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQ 656
GS GLG ++ G E GIFV I+ GG A G L+ DQ+++VNG L G +++
Sbjct: 427 GSTGLGFNIVGGEDGE-----GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHE 481
Query: 657 DAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDD-RERRIS 715
A L+ + G I+A+ P E + D RE+ ++
Sbjct: 482 QAAAALKGA--------GQTVTIIAQ------------YQPEDYARFEAKIHDLREQMMN 521
Query: 716 HSLYSGIEGLDESPSRN 732
HS+ SG L + R+
Sbjct: 522 HSMSSGSGSLRTNQKRS 538
Score = 34.3 bits (77), Expect = 0.83
Identities = 14/48 (29%), Positives = 26/48 (54%)
Query: 300 GLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFRQA 347
G+ + ++ GG A + R NDCI+R+N+ D+ +A ++A
Sbjct: 126 GIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEA 173
>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform a [Homo sapiens]
Length = 1287
Score = 83.6 bits (205), Expect = 1e-15
Identities = 112/474 (23%), Positives = 185/474 (39%), Gaps = 95/474 (20%)
Query: 267 SLDDMVKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVR 326
S+ +L+ V GP+G + GG G VK++ + +E D IV
Sbjct: 634 SIATQPELITVHIVKGPMGFGFTIADSPGGG--GQRVKQIVDSPRCRG---LKEGDLIVE 688
Query: 327 INDGDLRNRRFEQAQHMFRQAMR----TPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRF 382
+N +++ Q M + + T ++ +P K Q + +
Sbjct: 689 VNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERK--------- 739
Query: 383 SPDSQYIDNRSVNS-AGLHTVQRAPRLNHPPEQIDSHSRLPHSAHPSGKPPSAP------ 435
DSQ SV+S LHT + PE + ++ P SG+ P
Sbjct: 740 --DSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQ 797
Query: 436 --ASAPQNVFSTTVSSGYNTKKIGKRLN----------------IQLKKGTEGLGFSITS 477
+ S + +SG + + + +N I L + G GF I
Sbjct: 798 SRSMYENRPMSPSPASGLSKGEREREINSTNFGECPIPDYQEQDIFLWRKETGFGFRI-- 855
Query: 478 RDVTIGGSAP---IYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
+GG+ P IY+ +I+P GAA DGRL++GD LI V+G ++GKS + VV L++
Sbjct: 856 ----LGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQA 911
Query: 535 KMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETK--AEDEDIVLTPDGTREFLTFEVP 592
+G V+L V R+ P+ N PS + A + TP G++ L V
Sbjct: 912 AKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLN-TVS 970
Query: 593 LNDSGSAGLGVSVKGN---------------RSKENHADLGIFVKS-------------- 623
++G+G G R EN + V S
Sbjct: 971 SGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNAC 1030
Query: 624 ---------IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMST 668
II G A + G+L+V D+++AVNG S+ K++ D + ++ + +T
Sbjct: 1031 VAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNT 1084
Score = 76.6 bits (187), Expect = 1e-13
Identities = 75/291 (25%), Positives = 133/291 (45%), Gaps = 59/291 (20%)
Query: 422 PHSAHPSGKPPSA------PASAPQNVFSTTVSSGYNTKKIG--------------KRLN 461
P S+H S P++ QN +T S +T IG + +
Sbjct: 939 PASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYD 998
Query: 462 IQLKKG-TEGLGFSITSR------DVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRL 511
+++++G EG GF I S T G + P + I+ A + G+LK GDR+
Sbjct: 999 VEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRI 1058
Query: 512 IEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPREL-NAE----------P 560
+ VNG + KS ++V+L++ + TV+L + +++ + L NAE P
Sbjct: 1059 LAVNGCSITNKSHSDIVNLIK--EAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTP 1116
Query: 561 SQMQIPKET------KAEDEDIVLTPDGTRE--FLTFEVPLNDSGSAGLGVSVKGNRSKE 612
SQ Q +ET K E + P T+E F T E+ + G+ G G S++G R
Sbjct: 1117 SQ-QGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVEL---ERGAKGFGFSLRGGR--- 1169
Query: 613 NHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLR 663
++ ++V + G A + G++R+ D+++ +NGE+ + A+E ++
Sbjct: 1170 -EYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIK 1219
Score = 59.7 bits (143), Expect = 2e-08
Identities = 131/576 (22%), Positives = 208/576 (36%), Gaps = 165/576 (28%)
Query: 234 EKQEQDEDGTEEDNSRVEPVGHADTGLEHIPNFSLDDMVKLVEVPNDGGPL--------- 284
++Q+Q E+ TE+ ++ V PV IPN + EVP G P
Sbjct: 417 QQQQQTEEWTEDHSALVPPV---------IPNHPPSNPEPAREVPLQGKPFFTRNPSELK 467
Query: 285 GIHVVPFSARGGRTLG------------LLVKRLEKGGKAEHENLFRENDCIVRINDGDL 332
G + + R G L +K L G A + D IV +ND +
Sbjct: 468 GKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCV 527
Query: 333 RNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNR 392
Q +F+ +P E Y F PD +
Sbjct: 528 LGHTHAQVVKIFQS-----------IPIGASVDLELCRG------YPLPFDPDDP--NTS 568
Query: 393 SVNSAGLHTVQRAPRLNHPPEQIDSHSRLPHSAHPSGKP-------PSAPASAPQNVF-- 443
V S + + + P + + E DS + HS+ +GK PS+PA N
Sbjct: 569 LVTSVAI--LDKEPIIVNGQETYDSPAS--HSSK-TGKVNGMKDARPSSPADVASNSSHG 623
Query: 444 --STTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQ 501
+ TVS + + + + + KG G GF+I G V + RG
Sbjct: 624 YPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRG---- 679
Query: 502 DGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFR--------------- 546
LK GD ++EVN ++ + +VV +L V+LLV R
Sbjct: 680 ---LKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPL 736
Query: 547 ---------QEDAFHPRELN-AEPSQM-QI-----PKETKAEDEDIVLTPDGTREFLTFE 590
Q R L+ A PS Q+ P E +A D+ G ++ F+
Sbjct: 737 ERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQT---DSSGQKKPDPFK 793
Query: 591 V-----------PLNDSGSAGLGVSVKGNRSKE-NHADLG-------------------- 618
+ P++ S ++GL KG R +E N + G
Sbjct: 794 IWAQSRSMYENRPMSPSPASGLS---KGEREREINSTNFGECPIPDYQEQDIFLWRKETG 850
Query: 619 --------------IFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRR 664
I++ I+ GAA DGRLR D+LI V+G ++GK++Q ++ +++
Sbjct: 851 FGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQ 910
Query: 665 SMSTEGNKRGMIQLIVARRI-----SKCNELKSPGS 695
+ K+G + L V R++ NE+ SP S
Sbjct: 911 AA-----KQGHVNLTVRRKVVFAVPKTENEVPSPAS 941
Score = 53.5 bits (127), Expect = 1e-06
Identities = 38/148 (25%), Positives = 72/148 (48%), Gaps = 11/148 (7%)
Query: 403 QRAPRLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKI-GKRLN 461
Q+ + E + HS L P+ PPS P A + N ++ GK ++
Sbjct: 414 QQQQQQQQTEEWTEDHSALVPPVIPN-HPPSNPEPAREVPLQGKPFFTRNPSELKGKFIH 472
Query: 462 IQLKKGTEGLGFSITSRDVTIGGSAP---IYVKNILPRGAAIQDGRLKAGDRLIEVNGVD 518
+L+K + G GF++ +GG P + +K+++ G A DG+++ GD ++ VN
Sbjct: 473 TKLRKSSRGFGFTV------VGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTC 526
Query: 519 LVGKSQEEVVSLLRSTKMEGTVSLLVFR 546
++G + +VV + +S + +V L + R
Sbjct: 527 VLGHTHAQVVKIFQSIPIGASVDLELCR 554
Score = 39.3 bits (90), Expect = 0.026
Identities = 39/234 (16%), Positives = 87/234 (37%), Gaps = 53/234 (22%)
Query: 303 VKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPAAN 362
+ R+ +G A+ + D I+ +N + N+ ++ ++A T + ++P
Sbjct: 1037 IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNT--VTLRIIPGDE 1094
Query: 363 KEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAPRLNHPPEQIDSHSRLP 422
L+ +EK ++ +P Q Q P ++ + P
Sbjct: 1095 SSNATLLTNAEKIATITTTHTPSQQ-------------GTQETRNTTKPKQESQFEFKAP 1141
Query: 423 HSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTI 482
A+ Q+ ++ ++L++G +G GFS+
Sbjct: 1142 Q------------ATQEQDFYT-----------------VELERGAKGFGFSLR------ 1166
Query: 483 GG---SAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRS 533
GG + +YV + G A + G+++ GD ++E+NG + L+++
Sbjct: 1167 GGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKN 1220
Score = 37.0 bits (84), Expect = 0.13
Identities = 35/154 (22%), Positives = 63/154 (40%), Gaps = 21/154 (13%)
Query: 598 SAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQD 657
S G G +V G + D + +KS++ G A+ DG++ D +++VN +LG T+
Sbjct: 479 SRGFGFTVVGG----DEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQ 534
Query: 658 AMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIET--ALDDRERRIS 715
++ + I + + + C P P P + T A+ D+E I
Sbjct: 535 VVKIFQ-----------SIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPII- 582
Query: 716 HSLYSGIEGLDESPSRNAALSRIMGESGKYQLSP 749
+G E D S ++ ++ G SP
Sbjct: 583 ---VNGQETYDSPASHSSKTGKVNGMKDARPSSP 613
Score = 31.6 bits (70), Expect = 5.4
Identities = 21/76 (27%), Positives = 40/76 (52%), Gaps = 15/76 (19%)
Query: 1281 LETQELLRQEQRRKEQQMKKQPPSEGPSNYDSYKKVQDPSYAPPKGPFRQDVPPSPSQVA 1340
LE Q+ +Q+Q++++QQ ++Q E ++ + PP P + PPS + A
Sbjct: 400 LEQQQQQQQQQQQQQQQQQQQQTEEWTEDHS--------ALVPPVIP---NHPPSNPEPA 448
Query: 1341 RLNRLQTPEKGRPFYS 1356
R + P +G+PF++
Sbjct: 449 R----EVPLQGKPFFT 460
>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform b [Homo sapiens]
Length = 1256
Score = 83.2 bits (204), Expect = 2e-15
Identities = 112/475 (23%), Positives = 185/475 (38%), Gaps = 96/475 (20%)
Query: 267 SLDDMVKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVR 326
S+ +L+ V GP+G + GG G VK++ + +E D IV
Sbjct: 634 SIATQPELITVHIVKGPMGFGFTIADSPGGG--GQRVKQIVDSPRCRG---LKEGDLIVE 688
Query: 327 INDGDLRNRRFEQAQHMFRQAMR----TPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRF 382
+N +++ Q M + + T ++ +P K Q + +
Sbjct: 689 VNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERK--------- 739
Query: 383 SPDSQYIDNRSVNS-AGLHTVQRAPRLNHPPEQIDSHSRLPHSAHPSGKPPSAP------ 435
DSQ SV+S LHT + PE + ++ P SG+ P
Sbjct: 740 --DSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQ 797
Query: 436 --ASAPQNVFSTTVSSGYNTKKIGKRLN----------------IQLKKGTEGLGFSITS 477
+ S + +SG + + + +N I L + G GF I
Sbjct: 798 SRSMYENRPMSPSPASGLSKGEREREINSTNFGECPIPDYQEQDIFLWRKETGFGFRI-- 855
Query: 478 RDVTIGGSAP---IYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
+GG+ P IY+ +I+P GAA DGRL++GD LI V+G ++GKS + VV L++
Sbjct: 856 ----LGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQA 911
Query: 535 KMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETK--AEDEDIVLTPDGTREFLTFEVP 592
+G V+L V R+ P+ N PS + A + TP G++ L V
Sbjct: 912 AKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLN-TVS 970
Query: 593 LNDSGSAGLGVSVKGN---------------RSKENHADLGIFVKS-------------- 623
++G+G G R EN + V S
Sbjct: 971 SGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFAGNA 1030
Query: 624 ----------IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMST 668
II G A + G+L+V D+++AVNG S+ K++ D + ++ + +T
Sbjct: 1031 CVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNT 1085
Score = 77.8 bits (190), Expect = 7e-14
Identities = 76/292 (26%), Positives = 134/292 (45%), Gaps = 60/292 (20%)
Query: 422 PHSAHPSGKPPSA------PASAPQNVFSTTVSSGYNTKKIG--------------KRLN 461
P S+H S P++ QN +T S +T IG + +
Sbjct: 939 PASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYD 998
Query: 462 IQLKKG-TEGLGFSITSR------DVTIGGSA----PIYVKNILPRGAAIQDGRLKAGDR 510
+++++G EG GF I S T G+A P + I+ A + G+LK GDR
Sbjct: 999 VEIRRGENEGFGFVIVSSVSRPEAGTTFAGNACVAMPHKIGRIIEGSPADRCGKLKVGDR 1058
Query: 511 LIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPREL-NAE---------- 559
++ VNG + KS ++V+L++ + TV+L + +++ + L NAE
Sbjct: 1059 ILAVNGCSITNKSHSDIVNLIK--EAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHT 1116
Query: 560 PSQMQIPKET------KAEDEDIVLTPDGTRE--FLTFEVPLNDSGSAGLGVSVKGNRSK 611
PSQ Q +ET K E + P T+E F T E+ + G+ G G S++G R
Sbjct: 1117 PSQ-QGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVEL---ERGAKGFGFSLRGGR-- 1170
Query: 612 ENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLR 663
++ ++V + G A + G++R+ D+++ +NGE+ + A+E ++
Sbjct: 1171 --EYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIK 1220
Score = 59.7 bits (143), Expect = 2e-08
Identities = 131/576 (22%), Positives = 208/576 (36%), Gaps = 165/576 (28%)
Query: 234 EKQEQDEDGTEEDNSRVEPVGHADTGLEHIPNFSLDDMVKLVEVPNDGGPL--------- 284
++Q+Q E+ TE+ ++ V PV IPN + EVP G P
Sbjct: 417 QQQQQTEEWTEDHSALVPPV---------IPNHPPSNPEPAREVPLQGKPFFTRNPSELK 467
Query: 285 GIHVVPFSARGGRTLG------------LLVKRLEKGGKAEHENLFRENDCIVRINDGDL 332
G + + R G L +K L G A + D IV +ND +
Sbjct: 468 GKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCV 527
Query: 333 RNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNR 392
Q +F+ +P E Y F PD +
Sbjct: 528 LGHTHAQVVKIFQS-----------IPIGASVDLELCRG------YPLPFDPDDP--NTS 568
Query: 393 SVNSAGLHTVQRAPRLNHPPEQIDSHSRLPHSAHPSGKP-------PSAPASAPQNVF-- 443
V S + + + P + + E DS + HS+ +GK PS+PA N
Sbjct: 569 LVTSVAI--LDKEPIIVNGQETYDSPAS--HSSK-TGKVNGMKDARPSSPADVASNSSHG 623
Query: 444 --STTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQ 501
+ TVS + + + + + KG G GF+I G V + RG
Sbjct: 624 YPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRG---- 679
Query: 502 DGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFR--------------- 546
LK GD ++EVN ++ + +VV +L V+LLV R
Sbjct: 680 ---LKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPL 736
Query: 547 ---------QEDAFHPRELN-AEPSQM-QI-----PKETKAEDEDIVLTPDGTREFLTFE 590
Q R L+ A PS Q+ P E +A D+ G ++ F+
Sbjct: 737 ERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQT---DSSGQKKPDPFK 793
Query: 591 V-----------PLNDSGSAGLGVSVKGNRSKE-NHADLG-------------------- 618
+ P++ S ++GL KG R +E N + G
Sbjct: 794 IWAQSRSMYENRPMSPSPASGLS---KGEREREINSTNFGECPIPDYQEQDIFLWRKETG 850
Query: 619 --------------IFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRR 664
I++ I+ GAA DGRLR D+LI V+G ++GK++Q ++ +++
Sbjct: 851 FGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQ 910
Query: 665 SMSTEGNKRGMIQLIVARRI-----SKCNELKSPGS 695
+ K+G + L V R++ NE+ SP S
Sbjct: 911 AA-----KQGHVNLTVRRKVVFAVPKTENEVPSPAS 941
Score = 53.5 bits (127), Expect = 1e-06
Identities = 38/148 (25%), Positives = 72/148 (48%), Gaps = 11/148 (7%)
Query: 403 QRAPRLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKI-GKRLN 461
Q+ + E + HS L P+ PPS P A + N ++ GK ++
Sbjct: 414 QQQQQQQQTEEWTEDHSALVPPVIPN-HPPSNPEPAREVPLQGKPFFTRNPSELKGKFIH 472
Query: 462 IQLKKGTEGLGFSITSRDVTIGGSAP---IYVKNILPRGAAIQDGRLKAGDRLIEVNGVD 518
+L+K + G GF++ +GG P + +K+++ G A DG+++ GD ++ VN
Sbjct: 473 TKLRKSSRGFGFTV------VGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTC 526
Query: 519 LVGKSQEEVVSLLRSTKMEGTVSLLVFR 546
++G + +VV + +S + +V L + R
Sbjct: 527 VLGHTHAQVVKIFQSIPIGASVDLELCR 554
Score = 39.3 bits (90), Expect = 0.026
Identities = 39/234 (16%), Positives = 87/234 (37%), Gaps = 53/234 (22%)
Query: 303 VKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPAAN 362
+ R+ +G A+ + D I+ +N + N+ ++ ++A T + ++P
Sbjct: 1038 IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNT--VTLRIIPGDE 1095
Query: 363 KEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAPRLNHPPEQIDSHSRLP 422
L+ +EK ++ +P Q Q P ++ + P
Sbjct: 1096 SSNATLLTNAEKIATITTTHTPSQQ-------------GTQETRNTTKPKQESQFEFKAP 1142
Query: 423 HSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTI 482
A+ Q+ ++ ++L++G +G GFS+
Sbjct: 1143 Q------------ATQEQDFYT-----------------VELERGAKGFGFSLR------ 1167
Query: 483 GG---SAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRS 533
GG + +YV + G A + G+++ GD ++E+NG + L+++
Sbjct: 1168 GGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKN 1221
Score = 37.0 bits (84), Expect = 0.13
Identities = 35/154 (22%), Positives = 63/154 (40%), Gaps = 21/154 (13%)
Query: 598 SAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQD 657
S G G +V G + D + +KS++ G A+ DG++ D +++VN +LG T+
Sbjct: 479 SRGFGFTVVGG----DEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQ 534
Query: 658 AMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIET--ALDDRERRIS 715
++ + I + + + C P P P + T A+ D+E I
Sbjct: 535 VVKIFQ-----------SIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPII- 582
Query: 716 HSLYSGIEGLDESPSRNAALSRIMGESGKYQLSP 749
+G E D S ++ ++ G SP
Sbjct: 583 ---VNGQETYDSPASHSSKTGKVNGMKDARPSSP 613
Score = 31.6 bits (70), Expect = 5.4
Identities = 21/76 (27%), Positives = 40/76 (52%), Gaps = 15/76 (19%)
Query: 1281 LETQELLRQEQRRKEQQMKKQPPSEGPSNYDSYKKVQDPSYAPPKGPFRQDVPPSPSQVA 1340
LE Q+ +Q+Q++++QQ ++Q E ++ + PP P + PPS + A
Sbjct: 400 LEQQQQQQQQQQQQQQQQQQQQTEEWTEDHS--------ALVPPVIP---NHPPSNPEPA 448
Query: 1341 RLNRLQTPEKGRPFYS 1356
R + P +G+PF++
Sbjct: 449 R----EVPLQGKPFFT 460
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 82.4 bits (202), Expect = 3e-15
Identities = 73/241 (30%), Positives = 107/241 (44%), Gaps = 45/241 (18%)
Query: 460 LNIQLKKGTEGLGFSITSR--DVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGV 517
+ + L KG +GLGFSI + I G IY+ I+ GAA +DGRL+ GDRL+ VN
Sbjct: 225 MEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNT 284
Query: 518 DLVGKSQEEVVSLLRSTKMEGTVSLLVFRQ-----EDAFHPRE----------------- 555
+L EE V+ L++T V L V + D + P +
Sbjct: 285 NLQDVRHEEAVASLKNT--SDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNS 342
Query: 556 ----LNAEPSQMQIPKETKAE-------DEDIVLTPDGTREFLTFEVPLNDSGSAGLGVS 604
L A S++ P + ++ D TRE + GS GLG +
Sbjct: 343 SLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKI---ILHKGSTGLGFN 399
Query: 605 VKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRR 664
+ G E GIFV I+ GG A G LR D++++VNG +L T++ A L+R
Sbjct: 400 IVGGEDGE-----GIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKR 454
Query: 665 S 665
+
Sbjct: 455 A 455
Score = 81.6 bits (200), Expect = 5e-15
Identities = 83/270 (30%), Positives = 116/270 (42%), Gaps = 52/270 (19%)
Query: 462 IQLKKGTEGLGFSITSR--DVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDL 519
I L++G GLGFSI + + I++ I+P GAA DGRL D ++ VN VD+
Sbjct: 132 IVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDV 191
Query: 520 VGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLT 579
V L+ G V LV R+ Q P ET E +
Sbjct: 192 SEVVHSRAVEALKEA---GPVVRLVVRRR---------------QPPPETIMEVNLL--- 230
Query: 580 PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKEN-HADLGIFVKSIINGGAASKDGRLRV 638
G GLG S+ G ++ D I++ II GGAA KDGRL++
Sbjct: 231 ----------------KGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQI 274
Query: 639 NDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPG 698
D+L+AVN +L +++A+ +L+ N M+ L VA+ S L +PP
Sbjct: 275 GDRLLAVNNTNLQDVRHEEAVASLK-------NTSDMVYLKVAKPGSL--HLNDMYAPPD 325
Query: 699 PELPIETALDDRERRISHSLYSGIEGLDES 728
TAL D ISH+ G G ES
Sbjct: 326 YASTF-TALAD--NHISHNSSLGYLGAVES 352
Score = 54.3 bits (129), Expect = 8e-07
Identities = 48/167 (28%), Positives = 76/167 (45%), Gaps = 21/167 (12%)
Query: 581 DGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHAD-LGIFVKSIINGGAASKDGRLRVN 639
+G+ +E + + G++GLG S+ G + D GIF+ II GGAA+ DGRL VN
Sbjct: 121 NGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVN 180
Query: 640 DQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGP 699
D ++ VN + + A+E L+ + +++L+V RR P P
Sbjct: 181 DCVLRVNEVDVSEVVHSRAVEALKEA-------GPVVRLVVRRR------------QPPP 221
Query: 700 ELPIETALDDRERRISHSLYSGIEGLDESPSRNAALSRIMGESGKYQ 746
E +E L + + S+ GI G P N+ + E G Q
Sbjct: 222 ETIMEVNLLKGPKGLGFSIAGGI-GNQHIPGDNSIYITKIIEGGAAQ 267
Score = 51.2 bits (121), Expect = 7e-06
Identities = 53/242 (21%), Positives = 105/242 (43%), Gaps = 37/242 (15%)
Query: 301 LLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPA 360
+ + ++ +GG A+ + + D ++ +N+ +L++ R E+A + + +++ V
Sbjct: 255 IYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNT--SDMVYLKVAKP 312
Query: 361 ANKEQYEQLSQSEKNNYYSSRFSP--DSQYIDNRSVNSAGLHTVQRAPRLNHPPEQIDSH 418
+ + + + Y+S F+ D+ N S+ G
Sbjct: 313 GSLHLNDMYAPPD----YASTFTALADNHISHNSSLGYLGA-----------------VE 351
Query: 419 SRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSR 478
S++ + A P PP+ + P+++ + + K I L KG+ GLGF+I
Sbjct: 352 SKVSYPAPPQ-VPPTRYSPIPRHMLAEEDFTREPRKII-------LHKGSTGLGFNIVGG 403
Query: 479 DVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEG 538
+ G I+V IL G A G L+ GDR++ VNGV+L + E+ + L+
Sbjct: 404 EDGEG----IFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSV 459
Query: 539 TV 540
T+
Sbjct: 460 TI 461
Score = 31.2 bits (69), Expect = 7.1
Identities = 22/86 (25%), Positives = 38/86 (44%), Gaps = 10/86 (11%)
Query: 269 DDMVKLVEVPNDGGPLGIHVVPFSARGG-------RTLGLLVKRLEKGGKAEHENLFREN 321
D M K E+ + G G+ FS GG G+ + ++ GG A + N
Sbjct: 124 DGMFKYEEIVLERGNSGLG---FSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVN 180
Query: 322 DCIVRINDGDLRNRRFEQAQHMFRQA 347
DC++R+N+ D+ +A ++A
Sbjct: 181 DCVLRVNEVDVSEVVHSRAVEALKEA 206
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 81.6 bits (200), Expect = 5e-15
Identities = 76/253 (30%), Positives = 113/253 (44%), Gaps = 45/253 (17%)
Query: 421 LPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLN-----IQLKKGTEGLGFSI 475
LP A + P+ P + P V T S T G + I L++G GLGFSI
Sbjct: 179 LPVPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSI 238
Query: 476 T--SRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRS 533
+ + IG + I++ I+ GAA QDGRL+ D ++ VN VD+ + + V L
Sbjct: 239 AGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEAL-- 296
Query: 534 TKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPL 593
K G++ L K K E I+ E+ L
Sbjct: 297 -KEAGSIVRLYV---------------------KRRKPVSEKIM------------EIKL 322
Query: 594 NDSGSAGLGVSVKGNRSKEN-HADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLG 652
G GLG S+ G ++ D I+V II GGAA KDG+L++ D+L+AVN L
Sbjct: 323 -IKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEE 381
Query: 653 KTNQDAMETLRRS 665
T+++A+ L+ +
Sbjct: 382 VTHEEAVTALKNT 394
Score = 81.6 bits (200), Expect = 5e-15
Identities = 71/231 (30%), Positives = 109/231 (47%), Gaps = 34/231 (14%)
Query: 458 KRLNIQLKKGTEGLGFSITSR--DVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVN 515
K + I+L KG +GLGFSI + I G IYV I+ GAA +DG+L+ GD+L+ VN
Sbjct: 316 KIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVN 375
Query: 516 GVDLVGKSQEEVVSLLRST------KMEGTVSLLVFRQEDAFHPRELNAEPSQ------- 562
V L + EE V+ L++T K+ S+ + D + P ++ SQ
Sbjct: 376 NVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYM---NDGYAPPDITNSSSQPVDNHVS 432
Query: 563 --------MQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENH 614
P + ++ + TRE +V L+ GS GLG ++ G E
Sbjct: 433 PSSFLGQTPASPARYSPVSKAVLGDDEITRE--PRKVVLH-RGSTGLGFNIVGGEDGE-- 487
Query: 615 ADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 665
GIF+ I+ GG A G LR D++I+VN L +++ A L+ +
Sbjct: 488 ---GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNA 535
Score = 60.1 bits (144), Expect = 1e-08
Identities = 45/143 (31%), Positives = 71/143 (49%), Gaps = 11/143 (7%)
Query: 581 DGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHAD-LGIFVKSIINGGAASKDGRLRVN 639
+GT +E + G++GLG S+ G + D IF+ II GGAA++DGRLRVN
Sbjct: 214 NGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVN 273
Query: 640 DQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARR---ISKCNELKSPGSP 696
D ++ VN + T+ A+E L+ + S +++L V RR K E+K P
Sbjct: 274 DCILRVNEVDVRDVTHSKAVEALKEAGS-------IVRLYVKRRKPVSEKIMEIKLIKGP 326
Query: 697 PGPELPIETALDDRERRISHSLY 719
G I + ++ +S+Y
Sbjct: 327 KGLGFSIAGGVGNQHIPGDNSIY 349
Score = 54.3 bits (129), Expect = 8e-07
Identities = 66/300 (22%), Positives = 111/300 (37%), Gaps = 61/300 (20%)
Query: 296 GRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWF 355
G + + ++ GG A + R NDCI+R+N+ D+R+ +A ++A I+
Sbjct: 248 GDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEA--GSIVRL 305
Query: 356 HV---VPAANKEQYEQLSQSEKNNYYSSRFSPDSQYI--DNR------------------ 392
+V P + K +L + K +S +Q+I DN
Sbjct: 306 YVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKL 365
Query: 393 -------SVNSAGLHTVQRAP--------------RLNHPPEQIDSHSRLPHSAHPSGKP 431
+VN+ L V ++ P + P S
Sbjct: 366 QIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQ 425
Query: 432 PSAPASAPQNVFSTTVSSGYNTKKIGKRL-----------NIQLKKGTEGLGFSITSRDV 480
P +P + T +S + K + + L +G+ GLGF+I +
Sbjct: 426 PVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGED 485
Query: 481 TIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTV 540
G I++ IL G A G L+ GDR+I VN VDL S E+ + L++ T+
Sbjct: 486 GEG----IFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTI 541
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 81.6 bits (200), Expect = 5e-15
Identities = 76/253 (30%), Positives = 113/253 (44%), Gaps = 45/253 (17%)
Query: 421 LPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLN-----IQLKKGTEGLGFSI 475
LP A + P+ P + P V T S T G + I L++G GLGFSI
Sbjct: 179 LPVPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSI 238
Query: 476 T--SRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRS 533
+ + IG + I++ I+ GAA QDGRL+ D ++ VN VD+ + + V L
Sbjct: 239 AGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEAL-- 296
Query: 534 TKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPL 593
K G++ L K K E I+ E+ L
Sbjct: 297 -KEAGSIVRLYV---------------------KRRKPVSEKIM------------EIKL 322
Query: 594 NDSGSAGLGVSVKGNRSKEN-HADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLG 652
G GLG S+ G ++ D I+V II GGAA KDG+L++ D+L+AVN L
Sbjct: 323 -IKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEE 381
Query: 653 KTNQDAMETLRRS 665
T+++A+ L+ +
Sbjct: 382 VTHEEAVTALKNT 394
Score = 81.6 bits (200), Expect = 5e-15
Identities = 71/231 (30%), Positives = 109/231 (47%), Gaps = 34/231 (14%)
Query: 458 KRLNIQLKKGTEGLGFSITSR--DVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVN 515
K + I+L KG +GLGFSI + I G IYV I+ GAA +DG+L+ GD+L+ VN
Sbjct: 316 KIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVN 375
Query: 516 GVDLVGKSQEEVVSLLRST------KMEGTVSLLVFRQEDAFHPRELNAEPSQ------- 562
V L + EE V+ L++T K+ S+ + D + P ++ SQ
Sbjct: 376 NVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYM---NDGYAPPDITNSSSQPVDNHVS 432
Query: 563 --------MQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENH 614
P + ++ + TRE +V L+ GS GLG ++ G E
Sbjct: 433 PSSFLGQTPASPARYSPVSKAVLGDDEITRE--PRKVVLH-RGSTGLGFNIVGGEDGE-- 487
Query: 615 ADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 665
GIF+ I+ GG A G LR D++I+VN L +++ A L+ +
Sbjct: 488 ---GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNA 535
Score = 60.1 bits (144), Expect = 1e-08
Identities = 45/143 (31%), Positives = 71/143 (49%), Gaps = 11/143 (7%)
Query: 581 DGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHAD-LGIFVKSIINGGAASKDGRLRVN 639
+GT +E + G++GLG S+ G + D IF+ II GGAA++DGRLRVN
Sbjct: 214 NGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVN 273
Query: 640 DQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARR---ISKCNELKSPGSP 696
D ++ VN + T+ A+E L+ + S +++L V RR K E+K P
Sbjct: 274 DCILRVNEVDVRDVTHSKAVEALKEAGS-------IVRLYVKRRKPVSEKIMEIKLIKGP 326
Query: 697 PGPELPIETALDDRERRISHSLY 719
G I + ++ +S+Y
Sbjct: 327 KGLGFSIAGGVGNQHIPGDNSIY 349
Score = 54.3 bits (129), Expect = 8e-07
Identities = 66/300 (22%), Positives = 111/300 (37%), Gaps = 61/300 (20%)
Query: 296 GRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWF 355
G + + ++ GG A + R NDCI+R+N+ D+R+ +A ++A I+
Sbjct: 248 GDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEA--GSIVRL 305
Query: 356 HV---VPAANKEQYEQLSQSEKNNYYSSRFSPDSQYI--DNR------------------ 392
+V P + K +L + K +S +Q+I DN
Sbjct: 306 YVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKL 365
Query: 393 -------SVNSAGLHTVQRAP--------------RLNHPPEQIDSHSRLPHSAHPSGKP 431
+VN+ L V ++ P + P S
Sbjct: 366 QIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQ 425
Query: 432 PSAPASAPQNVFSTTVSSGYNTKKIGKRL-----------NIQLKKGTEGLGFSITSRDV 480
P +P + T +S + K + + L +G+ GLGF+I +
Sbjct: 426 PVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGED 485
Query: 481 TIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTV 540
G I++ IL G A G L+ GDR+I VN VDL S E+ + L++ T+
Sbjct: 486 GEG----IFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTI 541
>gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens]
Length = 728
Score = 80.9 bits (198), Expect = 8e-15
Identities = 91/357 (25%), Positives = 141/357 (39%), Gaps = 66/357 (18%)
Query: 300 GLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVP 359
G+ + + GG A END ++ IN DLR E A H+ + + R H+V
Sbjct: 405 GVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERR----VHLVV 460
Query: 360 AANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAPRLNHPPEQIDSHS 419
+ Q+ Q + + + ++ + + S G P+ HP I H
Sbjct: 461 S------RQVRQRSPDIFQEAGWNSNGSW-------SPGPGERSNTPKPLHPT--ITCHE 505
Query: 420 RLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRD 479
++ +NIQ G E LG ++
Sbjct: 506 KV--------------------------------------VNIQKDPG-ESLGMTVAGGA 526
Query: 480 VTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGT 539
PIYV ++ P G +DGR+K GD L+ V+GV+L S+ E V+LL+ T
Sbjct: 527 SHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIV 586
Query: 540 VSLLVFR----QEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLND 595
+ L + QED P L++ M P + + P + N
Sbjct: 587 LKALEVKEYEPQEDCSSPAALDSN-HNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNT 645
Query: 596 SGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLG 652
+GS LG + G +E + + F+KSI+ G A DGR+R D L+AVNG S G
Sbjct: 646 AGS--LGFCIVGG-YEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSG 699
Score = 68.2 bits (165), Expect = 5e-11
Identities = 55/186 (29%), Positives = 92/186 (49%), Gaps = 12/186 (6%)
Query: 488 IYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQ 547
+++ N+L G A + G+L+ DR++ +NG DL S E L++++ E V L+V RQ
Sbjct: 406 VFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQAS--ERRVHLVVSRQ 463
Query: 548 -----EDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLG 602
D F N+ S P E + + T + + + D G + LG
Sbjct: 464 VRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQ---KDPGES-LG 519
Query: 603 VSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETL 662
++V G S DL I+V S+ GG S+DGR++ D L+ V+G L + +A+ L
Sbjct: 520 MTVAGGASHREW-DLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALL 578
Query: 663 RRSMST 668
+R+ S+
Sbjct: 579 KRTSSS 584
Score = 58.2 bits (139), Expect = 5e-08
Identities = 53/208 (25%), Positives = 92/208 (44%), Gaps = 39/208 (18%)
Query: 482 IGGSAP----IYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKME 537
+GGS I +++I G +DGRL GD +++VNG+D+ V LLR
Sbjct: 291 VGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQ- 349
Query: 538 GTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSG 597
V L +E F R + Q P + D+ +F V LN S
Sbjct: 350 --VLWLTVMREQKFRSR------NNGQAPDAYRPRDD-------------SFHVILNKSS 388
Query: 598 -SAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQ 656
LG+ + + G+F+ ++++GG A + G+L ND+++A+NG L + +
Sbjct: 389 PEEQLGIKLVRKVDEP-----GVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPE 443
Query: 657 DAMETLRRSMSTEGNKRGMIQLIVARRI 684
A ++ S + L+V+R++
Sbjct: 444 SAAHLIQAS-------ERRVHLVVSRQV 464
Score = 45.4 bits (106), Expect = 4e-04
Identities = 27/84 (32%), Positives = 44/84 (52%), Gaps = 1/84 (1%)
Query: 461 NIQLKKGTEG-LGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDL 519
+I L++ T G LGF I G+ P ++K+I+ A DGR++ GD L+ VNG
Sbjct: 638 DIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRST 697
Query: 520 VGKSQEEVVSLLRSTKMEGTVSLL 543
G + LL+ K T++++
Sbjct: 698 SGMIHACLARLLKELKGRITLTIV 721
>gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens]
Length = 632
Score = 80.9 bits (198), Expect = 8e-15
Identities = 91/357 (25%), Positives = 141/357 (39%), Gaps = 66/357 (18%)
Query: 300 GLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVP 359
G+ + + GG A END ++ IN DLR E A H+ + + R H+V
Sbjct: 309 GVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERR----VHLVV 364
Query: 360 AANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAPRLNHPPEQIDSHS 419
+ Q+ Q + + + ++ + + S G P+ HP I H
Sbjct: 365 S------RQVRQRSPDIFQEAGWNSNGSW-------SPGPGERSNTPKPLHPT--ITCHE 409
Query: 420 RLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRD 479
++ +NIQ G E LG ++
Sbjct: 410 KV--------------------------------------VNIQKDPG-ESLGMTVAGGA 430
Query: 480 VTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGT 539
PIYV ++ P G +DGR+K GD L+ V+GV+L S+ E V+LL+ T
Sbjct: 431 SHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIV 490
Query: 540 VSLLVFR----QEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLND 595
+ L + QED P L++ M P + + P + N
Sbjct: 491 LKALEVKEYEPQEDCSSPAALDSN-HNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNT 549
Query: 596 SGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLG 652
+GS LG + G +E + + F+KSI+ G A DGR+R D L+AVNG S G
Sbjct: 550 AGS--LGFCIVGG-YEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSG 603
Score = 68.2 bits (165), Expect = 5e-11
Identities = 55/186 (29%), Positives = 92/186 (49%), Gaps = 12/186 (6%)
Query: 488 IYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQ 547
+++ N+L G A + G+L+ DR++ +NG DL S E L++++ E V L+V RQ
Sbjct: 310 VFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQAS--ERRVHLVVSRQ 367
Query: 548 -----EDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLG 602
D F N+ S P E + + T + + + D G + LG
Sbjct: 368 VRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQ---KDPGES-LG 423
Query: 603 VSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETL 662
++V G S DL I+V S+ GG S+DGR++ D L+ V+G L + +A+ L
Sbjct: 424 MTVAGGASHREW-DLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALL 482
Query: 663 RRSMST 668
+R+ S+
Sbjct: 483 KRTSSS 488
Score = 58.2 bits (139), Expect = 5e-08
Identities = 53/208 (25%), Positives = 92/208 (44%), Gaps = 39/208 (18%)
Query: 482 IGGSAP----IYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKME 537
+GGS I +++I G +DGRL GD +++VNG+D+ V LLR
Sbjct: 195 VGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQ- 253
Query: 538 GTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSG 597
V L +E F R + Q P + D+ +F V LN S
Sbjct: 254 --VLWLTVMREQKFRSR------NNGQAPDAYRPRDD-------------SFHVILNKSS 292
Query: 598 -SAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQ 656
LG+ + + G+F+ ++++GG A + G+L ND+++A+NG L + +
Sbjct: 293 PEEQLGIKLVRKVDEP-----GVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPE 347
Query: 657 DAMETLRRSMSTEGNKRGMIQLIVARRI 684
A ++ S + L+V+R++
Sbjct: 348 SAAHLIQAS-------ERRVHLVVSRQV 368
Score = 45.4 bits (106), Expect = 4e-04
Identities = 27/84 (32%), Positives = 44/84 (52%), Gaps = 1/84 (1%)
Query: 461 NIQLKKGTEG-LGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDL 519
+I L++ T G LGF I G+ P ++K+I+ A DGR++ GD L+ VNG
Sbjct: 542 DIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRST 601
Query: 520 VGKSQEEVVSLLRSTKMEGTVSLL 543
G + LL+ K T++++
Sbjct: 602 SGMIHACLARLLKELKGRITLTIV 625
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 79.0 bits (193), Expect = 3e-14
Identities = 76/267 (28%), Positives = 116/267 (43%), Gaps = 67/267 (25%)
Query: 419 SRLPHSAHPSGKP------------PSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKK 466
S LPHS+ P+ P P+ AP ++ + + Y ++I +L +
Sbjct: 957 SPLPHSSPPTAAVATTSITTATPGVPGLPSLAP-SLLAAALEGPYPVEEI------RLPR 1009
Query: 467 GTEGLGFSITS----RDVTIGGSAP-IYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
LG SI G P +++ +LPRG A + G L+ GDR++ VNG D+
Sbjct: 1010 AGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRD 1068
Query: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPD 581
+ +E VS L +E +SLLV R P
Sbjct: 1069 ATHQEAVSALLRPCLE--LSLLVRRDP------------------------------APP 1096
Query: 582 GTREFLTFEVPLNDSGSAGLGVSVKGNR-----SKENHADLGIFVKSIINGGAASKDGRL 636
G RE + P LG+S++G + + D GIF+ + GAA +DGRL
Sbjct: 1097 GLRELCIQKAP-----GERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRL 1151
Query: 637 RVNDQLIAVNGESLLGKTNQDAMETLR 663
RV +L+ VN +SLLG T+ +A++ LR
Sbjct: 1152 RVGLRLLEVNQQSLLGLTHGEAVQLLR 1178
Score = 77.4 bits (189), Expect = 9e-14
Identities = 64/219 (29%), Positives = 99/219 (45%), Gaps = 21/219 (9%)
Query: 464 LKKGTEGLGFSITSRDVTI---GGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
L + GLGFSI + G A I+V I GAA + G L+ GDR++ +NGVD+
Sbjct: 865 LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924
Query: 521 GKSQEEVVSLLRSTKMEGTVSLLVFRQ-------EDAFHPRELNAEPSQMQIPKETKAED 573
+ VSLL T T++LL+ R+ H A + I T
Sbjct: 925 EARHDHAVSLL--TAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVP 982
Query: 574 EDIVLTPDGTREFLTFEVPLND----SGSAGLGVSVKGNRSKENH----ADLGIFVKSII 625
L P L P+ + LG+S+ G +H + G+F+ ++
Sbjct: 983 GLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVL 1042
Query: 626 NGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRR 664
G A++ G LRV D+++AVNG+ + T+Q+A+ L R
Sbjct: 1043 PRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLR 1080
Score = 77.0 bits (188), Expect = 1e-13
Identities = 62/230 (26%), Positives = 98/230 (42%), Gaps = 32/230 (13%)
Query: 458 KRLNIQLKKGTEGLGFSITSRDVTI---GGSAPIYVKNILPRGAAIQDGRLKAGDRLIEV 514
+ L + + + T GLG SI + G I++ + G A + G ++ GD+L+EV
Sbjct: 725 EELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEV 783
Query: 515 NGVDLVGKSQEEVVSLLRST--------------KMEGTVSLLVFRQEDAFHPRELNAEP 560
NGV L G E V LR + E V++ R ED + PRE
Sbjct: 784 NGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRG-- 841
Query: 561 SQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENH--ADLG 618
+++P +L P+ V GLG S+ G + + D G
Sbjct: 842 GGLRLP----------LLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAG 891
Query: 619 IFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMST 668
IFV I GGAA + G L+V D+++++NG + + A+ L + T
Sbjct: 892 IFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPT 941
Score = 55.1 bits (131), Expect = 5e-07
Identities = 41/113 (36%), Positives = 59/113 (52%), Gaps = 7/113 (6%)
Query: 454 KKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIE 513
K G+RL I ++ G G + RD T G I++ + P GAA +DGRL+ G RL+E
Sbjct: 1105 KAPGERLGISIRGGARG--HAGNPRDPTDEG---IFISKVSPTGAAGRDGRLRVGLRLLE 1159
Query: 514 VNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIP 566
VN L+G + E V LLRS + T+++LV +A L P + P
Sbjct: 1160 VNQQSLLGLTHGEAVQLLRS--VGDTLTVLVCDGFEASTDAALEVSPGVIANP 1210
Score = 31.2 bits (69), Expect = 7.1
Identities = 21/74 (28%), Positives = 37/74 (50%), Gaps = 6/74 (8%)
Query: 272 VKLVEVPNDGGPLGIHVVPFSAR-----GGRTLGLLVKRLEKGGKAEHENLFRENDCIVR 326
V+ + +P GGPLG+ +V S G + G+ + ++ G A L R D I+
Sbjct: 1002 VEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGL-RVGDRILA 1060
Query: 327 INDGDLRNRRFEQA 340
+N D+R+ ++A
Sbjct: 1061 VNGQDVRDATHQEA 1074
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 79.0 bits (193), Expect = 3e-14
Identities = 76/267 (28%), Positives = 116/267 (43%), Gaps = 67/267 (25%)
Query: 419 SRLPHSAHPSGKP------------PSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKK 466
S LPHS+ P+ P P+ AP ++ + + Y ++I +L +
Sbjct: 957 SPLPHSSPPTAAVATTSITTATPGVPGLPSLAP-SLLAAALEGPYPVEEI------RLPR 1009
Query: 467 GTEGLGFSITS----RDVTIGGSAP-IYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
LG SI G P +++ +LPRG A + G L+ GDR++ VNG D+
Sbjct: 1010 AGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRD 1068
Query: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPD 581
+ +E VS L +E +SLLV R P
Sbjct: 1069 ATHQEAVSALLRPCLE--LSLLVRRDP------------------------------APP 1096
Query: 582 GTREFLTFEVPLNDSGSAGLGVSVKGNR-----SKENHADLGIFVKSIINGGAASKDGRL 636
G RE + P LG+S++G + + D GIF+ + GAA +DGRL
Sbjct: 1097 GLRELCIQKAP-----GERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRL 1151
Query: 637 RVNDQLIAVNGESLLGKTNQDAMETLR 663
RV +L+ VN +SLLG T+ +A++ LR
Sbjct: 1152 RVGLRLLEVNQQSLLGLTHGEAVQLLR 1178
Score = 77.4 bits (189), Expect = 9e-14
Identities = 64/219 (29%), Positives = 99/219 (45%), Gaps = 21/219 (9%)
Query: 464 LKKGTEGLGFSITSRDVTI---GGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
L + GLGFSI + G A I+V I GAA + G L+ GDR++ +NGVD+
Sbjct: 865 LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924
Query: 521 GKSQEEVVSLLRSTKMEGTVSLLVFRQ-------EDAFHPRELNAEPSQMQIPKETKAED 573
+ VSLL T T++LL+ R+ H A + I T
Sbjct: 925 EARHDHAVSLL--TAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVP 982
Query: 574 EDIVLTPDGTREFLTFEVPLND----SGSAGLGVSVKGNRSKENH----ADLGIFVKSII 625
L P L P+ + LG+S+ G +H + G+F+ ++
Sbjct: 983 GLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVL 1042
Query: 626 NGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRR 664
G A++ G LRV D+++AVNG+ + T+Q+A+ L R
Sbjct: 1043 PRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLR 1080
Score = 77.0 bits (188), Expect = 1e-13
Identities = 62/230 (26%), Positives = 98/230 (42%), Gaps = 32/230 (13%)
Query: 458 KRLNIQLKKGTEGLGFSITSRDVTI---GGSAPIYVKNILPRGAAIQDGRLKAGDRLIEV 514
+ L + + + T GLG SI + G I++ + G A + G ++ GD+L+EV
Sbjct: 725 EELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEV 783
Query: 515 NGVDLVGKSQEEVVSLLRST--------------KMEGTVSLLVFRQEDAFHPRELNAEP 560
NGV L G E V LR + E V++ R ED + PRE
Sbjct: 784 NGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRG-- 841
Query: 561 SQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENH--ADLG 618
+++P +L P+ V GLG S+ G + + D G
Sbjct: 842 GGLRLP----------LLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAG 891
Query: 619 IFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMST 668
IFV I GGAA + G L+V D+++++NG + + A+ L + T
Sbjct: 892 IFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPT 941
Score = 55.1 bits (131), Expect = 5e-07
Identities = 41/113 (36%), Positives = 59/113 (52%), Gaps = 7/113 (6%)
Query: 454 KKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIE 513
K G+RL I ++ G G + RD T G I++ + P GAA +DGRL+ G RL+E
Sbjct: 1105 KAPGERLGISIRGGARG--HAGNPRDPTDEG---IFISKVSPTGAAGRDGRLRVGLRLLE 1159
Query: 514 VNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIP 566
VN L+G + E V LLRS + T+++LV +A L P + P
Sbjct: 1160 VNQQSLLGLTHGEAVQLLRS--VGDTLTVLVCDGFEASTDAALEVSPGVIANP 1210
Score = 31.2 bits (69), Expect = 7.1
Identities = 21/74 (28%), Positives = 37/74 (50%), Gaps = 6/74 (8%)
Query: 272 VKLVEVPNDGGPLGIHVVPFSAR-----GGRTLGLLVKRLEKGGKAEHENLFRENDCIVR 326
V+ + +P GGPLG+ +V S G + G+ + ++ G A L R D I+
Sbjct: 1002 VEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGL-RVGDRILA 1060
Query: 327 INDGDLRNRRFEQA 340
+N D+R+ ++A
Sbjct: 1061 VNGQDVRDATHQEA 1074
>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
containing 2 [Homo sapiens]
Length = 1455
Score = 78.6 bits (192), Expect = 4e-14
Identities = 67/262 (25%), Positives = 117/262 (44%), Gaps = 33/262 (12%)
Query: 458 KRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGV 517
K L++ L++ G GF I D PI + ++ G+A +DGRL GD L+ V+G+
Sbjct: 775 KELDVHLRRMESGFGFRILGGDEP---GQPILIGAVIAMGSADRDGRLHPGDELVYVDGI 831
Query: 518 DLVGKSQEEVVSLLRSTKMEGTVSLLVFRQ---------EDAFHPRELNAEPSQMQIPKE 568
+ GK+ V+ L+ G V+L V R+ E+ P ++ S +
Sbjct: 832 PVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYA 891
Query: 569 T-----KAEDEDIVLTPDG--TREFLTFEVPLNDSGSAGLG-VSVKGNRSKENHADLGI- 619
T A P+G + T +V ++ + G G V + E+ + + +
Sbjct: 892 TYTNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVP 951
Query: 620 -FVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQL 678
+ II+G A + +L+V D+++AVNG+S++ + D ++ ++ + L
Sbjct: 952 HKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDA-----------GL 1000
Query: 679 IVARRISKCNELKSPGSPPGPE 700
V RI EL SP S P E
Sbjct: 1001 SVTLRIIPQEELNSPTSAPSSE 1022
Score = 60.5 bits (145), Expect = 1e-08
Identities = 41/129 (31%), Positives = 70/129 (54%), Gaps = 15/129 (11%)
Query: 421 LPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDV 480
+PH+ + KP AP + +F+ S + G L+ LKK G GF+I
Sbjct: 392 MPHTELGT-KPLQAPGFREKPLFTRDAS-----QLKGTFLSTTLKKSNMGFGFTI----- 440
Query: 481 TIGGSAP---IYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKME 537
IGG P + VK+++P G A QDG+++ GD ++ +N V ++G + +VV L +S +
Sbjct: 441 -IGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVPIG 499
Query: 538 GTVSLLVFR 546
+V+L++ R
Sbjct: 500 QSVNLVLCR 508
Score = 52.4 bits (124), Expect = 3e-06
Identities = 75/342 (21%), Positives = 126/342 (36%), Gaps = 85/342 (24%)
Query: 416 DSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSI 475
D R PHS H + P V VS + + + + + KG +G GF+I
Sbjct: 560 DITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQGFGFTI 619
Query: 476 TSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTK 535
D G VK IL L GD ++E+N ++ S EVV +L+
Sbjct: 620 A--DSPTGQR----VKQILDIQGC---PGLCEGDLIVEINQQNVQNLSHTEVVDILKDCP 670
Query: 536 MEGTVSLLVFR------------------------------------------------- 546
+ SL++ R
Sbjct: 671 IGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSFPD 730
Query: 547 QEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTR--------EFLTFEVPLNDSGS 598
+AF PR +P ++ ++++A E P T ++ +V L S
Sbjct: 731 STEAFDPR----KPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELDVHLRRMES 786
Query: 599 AGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDA 658
G G + G + I + ++I G+A +DGRL D+L+ V+G + GKT++
Sbjct: 787 -GFGFRILGG----DEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYV 841
Query: 659 METLRRSMSTEGNKRGMIQLIVARRI----SKCNEL-KSPGS 695
++ + + + G + L V R++ C E +SPGS
Sbjct: 842 IDLMHHAA-----RNGQVNLTVRRKVLCGGEPCPENGRSPGS 878
Score = 52.0 bits (123), Expect = 4e-06
Identities = 38/132 (28%), Positives = 68/132 (51%), Gaps = 18/132 (13%)
Query: 584 REFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLI 643
++F F V + + G+ G G S++G R + + ++V + G A ++GR+RV DQ+I
Sbjct: 1141 QDFDYFTVDM-EKGAKGFGFSIRGGREYK----MDLYVLRLAEDGPAIRNGRMRVGDQII 1195
Query: 644 AVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPG-----SPPG 698
+NGES T+ A+E ++ G +R ++L++ R + E P +
Sbjct: 1196 EINGESTRDMTHARAIELIK-----SGGRR--VRLLLKRGTGQVPEYDEPAPWSSPAAAA 1248
Query: 699 PELP-IETALDD 709
P LP + +LDD
Sbjct: 1249 PGLPEVGVSLDD 1260
Score = 45.8 bits (107), Expect = 3e-04
Identities = 24/75 (32%), Positives = 41/75 (54%), Gaps = 9/75 (12%)
Query: 462 IQLKKGTEGLGFSITSRDVTIGG---SAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVD 518
+ ++KG +G GFSI GG +YV + G AI++GR++ GD++IE+NG
Sbjct: 1148 VDMEKGAKGFGFSIR------GGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGES 1201
Query: 519 LVGKSQEEVVSLLRS 533
+ + L++S
Sbjct: 1202 TRDMTHARAIELIKS 1216
Score = 37.0 bits (84), Expect = 0.13
Identities = 24/95 (25%), Positives = 45/95 (47%), Gaps = 4/95 (4%)
Query: 566 PKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSII 625
P + E + T D ++ TF + G G ++ G + D + VKS+I
Sbjct: 401 PLQAPGFREKPLFTRDASQLKGTFLSTTLKKSNMGFGFTIIGG----DEPDEFLQVKSVI 456
Query: 626 NGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAME 660
G A++DG++ D ++ +N +LG T+ D ++
Sbjct: 457 PDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVK 491
>gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo
sapiens]
Length = 1287
Score = 76.6 bits (187), Expect = 1e-13
Identities = 95/390 (24%), Positives = 156/390 (40%), Gaps = 64/390 (16%)
Query: 300 GLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVP 359
G+ + + GG AE + I+ +N L F A M + + ++
Sbjct: 780 GIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDN----IELII 835
Query: 360 AANKEQYEQLSQSEKNNYYSSRFSP----------------DSQYIDNRSVNSAGLHTVQ 403
+ +K EKN+ +S S Q + ++ AG+ ++
Sbjct: 836 SQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSHTQDQDRNTEELDMAGVQSL- 894
Query: 404 RAPRLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQ 463
PRL H S LP S PPS P + ++ ++
Sbjct: 895 -VPRLRH------QLSFLPLKGAGSSCPPSPPEISAGEIYF-----------------VE 930
Query: 464 LKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKS 523
L K LGFS+T T IYVK+I+P G A ++G++ GDRL++V+GV L G +
Sbjct: 931 LVKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLT 990
Query: 524 QEEVVSLLRSTKMEGTVSLLVFR-------QEDAFHPRELNAEPSQMQIPKETKAEDEDI 576
++ V L G V+ LV Q+ + E + + +
Sbjct: 991 HKQAVQCLTG---PGQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSC 1047
Query: 577 VLTPDGTREFLTFEVPLNDSGSAGLGVS-VKGNRSKENH--ADLGIFVKSIINGGAASKD 633
V DG + FEV L + + GLG S V+ + +H +DL + +K + G A ++
Sbjct: 1048 VSVTDGPK----FEVKLKKNAN-GLGFSFVQMEKESCSHLKSDL-VRIKRLFPGQPAEEN 1101
Query: 634 GRLRVNDQLIAVNGESLLGKTNQDAMETLR 663
G + D ++AVNG S G Q+ + LR
Sbjct: 1102 GAIAAGDIILAVNGRSTEGLIFQEVLHLLR 1131
Score = 52.0 bits (123), Expect = 4e-06
Identities = 82/370 (22%), Positives = 143/370 (38%), Gaps = 69/370 (18%)
Query: 346 QAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRA 405
QA P+IW + + E + Q S+ S D+ +D AG + R+
Sbjct: 645 QARSKPLIWIQRLSCSENELFVSRLQGAAGGLLST--SMDNFNVDGSK--EAGAEGIGRS 700
Query: 406 PRLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKI-----GKRL 460
P EQ+ S + KP + + + V S S N +K G+ +
Sbjct: 701 PCTGR--EQLKSACVIQ-------KPMTWDSLSGPPVQSMHAGSKNNRRKSFIAEPGREI 751
Query: 461 -NIQLKKGTE-GLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVD 518
+ LK+ G GF I + + I++ +I+P G A + +K G +++ +N +
Sbjct: 752 VRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHIS 811
Query: 519 LVGKSQEEVVSLLR--------------------------STKMEGTV-----------S 541
L G + V +++ ST G S
Sbjct: 812 LEGFTFNMAVRMIQNSPDNIELIISQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGS 871
Query: 542 LLVFRQEDAFHPRELNAEPSQMQIPKETK---------AEDEDIVLTPDGTREFLTFEVP 592
LL Q+ + EL+ Q +P+ A P+ + + F
Sbjct: 872 LLSHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVEL 931
Query: 593 LNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLG 652
+ + G+ G V+ N S GI+VKSI+ GG A+K+G++ D+L+ V+G L G
Sbjct: 932 VKEDGTLGFSVTGGINTSVPYG---GIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCG 988
Query: 653 KTNQDAMETL 662
T++ A++ L
Sbjct: 989 LTHKQAVQCL 998
Score = 49.7 bits (117), Expect = 2e-05
Identities = 47/167 (28%), Positives = 75/167 (44%), Gaps = 8/167 (4%)
Query: 457 GKRLNIQLKKGTEGLGFSITSRDVTIGG---SAPIYVKNILPRGAAIQDGRLKAGDRLIE 513
G + ++LKK GLGFS + S + +K + P A ++G + AGD ++
Sbjct: 1053 GPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILA 1112
Query: 514 VNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPR-ELNAEPSQMQIPKE-TKA 571
VNG G +EV+ LLR E V+LL+ R P E + ++ KE T+A
Sbjct: 1113 VNGRSTEGLIFQEVLHLLRGAPQE--VTLLLCRPPPGALPELEQEWQTPELSADKEFTRA 1170
Query: 572 EDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLG 618
D +P +E + D+G GLG+ + ++ A G
Sbjct: 1171 TCTDSCTSPILDQEDSWRDSASPDAGE-GLGLRPESSQKAIREAQWG 1216
Score = 37.4 bits (85), Expect = 0.098
Identities = 21/51 (41%), Positives = 30/51 (58%)
Query: 615 ADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 665
AD GIF+ SII GG A K ++ Q++A+N SL G T A+ ++ S
Sbjct: 777 ADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNS 827
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.129 0.367
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,635,473
Number of Sequences: 37866
Number of extensions: 2722040
Number of successful extensions: 18935
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 281
Number of HSP's successfully gapped in prelim test: 579
Number of HSP's that attempted gapping in prelim test: 12297
Number of HSP's gapped (non-prelim): 4483
length of query: 1356
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1241
effective length of database: 13,892,928
effective search space: 17241123648
effective search space used: 17241123648
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.