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Search of human proteins with 21361142
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21361142 PDZ domain containing 1 [Homo sapiens]
(519 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21361142 PDZ domain containing 1 [Homo sapiens] 1032 0.0
gi|169217736 PREDICTED: similar to PDZ domain containing 1 [Homo... 351 8e-97
gi|21630285 PDZ domain containing 3 [Homo sapiens] 215 9e-56
gi|4759140 sodium/hydrogen exchanger regulatory factor 1 [Homo s... 162 7e-40
gi|194018553 solute carrier family 9 isoform 3 regulator 2 isofo... 141 2e-33
gi|71897229 solute carrier family 9 isoform 3 regulator 2 isofor... 141 2e-33
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 98 2e-20
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 98 2e-20
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 94 3e-19
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 94 3e-19
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 89 1e-17
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 87 3e-17
gi|218505835 membrane-associated guanylate kinase-related 3 iso... 87 4e-17
gi|155969695 membrane-associated guanylate kinase-related 3 iso... 87 4e-17
gi|148746189 multiple PDZ domain protein [Homo sapiens] 84 4e-16
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 81 3e-15
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 81 3e-15
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom... 79 8e-15
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom... 79 1e-14
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom... 78 2e-14
gi|45827729 scribble isoform b [Homo sapiens] 77 4e-14
gi|45827731 scribble isoform a [Homo sapiens] 77 4e-14
gi|112382257 InaD-like [Homo sapiens] 67 3e-11
gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo sa... 65 1e-10
gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo sa... 65 1e-10
gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens] 65 2e-10
gi|119120907 par-3 partitioning defective 3 homolog B isoform a ... 64 3e-10
gi|119120903 par-3 partitioning defective 3 homolog B isoform c ... 64 3e-10
gi|148727255 microtubule associated serine/threonine kinase fami... 62 1e-09
gi|13376349 PDZ domain containing 7 [Homo sapiens] 62 2e-09
>gi|21361142 PDZ domain containing 1 [Homo sapiens]
Length = 519
Score = 1032 bits (2669), Expect = 0.0
Identities = 519/519 (100%), Positives = 519/519 (100%)
Query: 1 MTSTFNPRECKLSKQEGQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRING 60
MTSTFNPRECKLSKQEGQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRING
Sbjct: 1 MTSTFNPRECKLSKQEGQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRING 60
Query: 61 VFVDKEEHMQVVDLVRKSGNSVTLLVLDGDSYEKAVKTRVDLKELGQSQKEQGLSDNILS 120
VFVDKEEHMQVVDLVRKSGNSVTLLVLDGDSYEKAVKTRVDLKELGQSQKEQGLSDNILS
Sbjct: 61 VFVDKEEHMQVVDLVRKSGNSVTLLVLDGDSYEKAVKTRVDLKELGQSQKEQGLSDNILS 120
Query: 121 PVMNGGVQTWTQPRLCYLVKEGGSYGFSLKTVQGKKGVYMTDITPQGVAMRAGVLADDHL 180
PVMNGGVQTWTQPRLCYLVKEGGSYGFSLKTVQGKKGVYMTDITPQGVAMRAGVLADDHL
Sbjct: 121 PVMNGGVQTWTQPRLCYLVKEGGSYGFSLKTVQGKKGVYMTDITPQGVAMRAGVLADDHL 180
Query: 181 IEVNGENVEDASHEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRETASLKLLPHQ 240
IEVNGENVEDASHEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRETASLKLLPHQ
Sbjct: 181 IEVNGENVEDASHEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRETASLKLLPHQ 240
Query: 241 PRIVEMKKGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVETLD 300
PRIVEMKKGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVETLD
Sbjct: 241 PRIVEMKKGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVETLD 300
Query: 301 HDSVVEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVKEAPAPTPTSL 360
HDSVVEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVKEAPAPTPTSL
Sbjct: 301 HDSVVEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVKEAPAPTPTSL 360
Query: 361 EVSSPPDTTEEVDHKPKLCRLAKGENGYGFHLNAIRGLPGSFIKEVQKGGPADLAGLEDE 420
EVSSPPDTTEEVDHKPKLCRLAKGENGYGFHLNAIRGLPGSFIKEVQKGGPADLAGLEDE
Sbjct: 361 EVSSPPDTTEEVDHKPKLCRLAKGENGYGFHLNAIRGLPGSFIKEVQKGGPADLAGLEDE 420
Query: 421 DVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTLLVCGKKAYDYFQAKKIPIVSSLADPLDT 480
DVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTLLVCGKKAYDYFQAKKIPIVSSLADPLDT
Sbjct: 421 DVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTLLVCGKKAYDYFQAKKIPIVSSLADPLDT 480
Query: 481 PPDSKEGIVVESNHDSHMAKERAHSTASHSSSNSEDTEM 519
PPDSKEGIVVESNHDSHMAKERAHSTASHSSSNSEDTEM
Sbjct: 481 PPDSKEGIVVESNHDSHMAKERAHSTASHSSSNSEDTEM 519
>gi|169217736 PREDICTED: similar to PDZ domain containing 1 [Homo
sapiens]
Length = 227
Score = 351 bits (901), Expect = 8e-97
Identities = 173/178 (97%), Positives = 174/178 (97%)
Query: 325 DNMYRLAHFSPFLYYQSQELPNGSVKEAPAPTPTSLEVSSPPDTTEEVDHKPKLCRLAKG 384
D +LAHFSPFLYYQSQELPNGSVKEAPAPTPTSLEVSSPPDTTEE DHKPKLCRLAKG
Sbjct: 4 DCQIQLAHFSPFLYYQSQELPNGSVKEAPAPTPTSLEVSSPPDTTEEEDHKPKLCRLAKG 63
Query: 385 ENGYGFHLNAIRGLPGSFIKEVQKGGPADLAGLEDEDVIIEVNGVNVLDEPYEKVVDRIQ 444
ENGYGFHLNAIRGLPGSFIKEVQKGGPADLAGLEDEDVIIEVNGVNVLDEPYEKVVDRIQ
Sbjct: 64 ENGYGFHLNAIRGLPGSFIKEVQKGGPADLAGLEDEDVIIEVNGVNVLDEPYEKVVDRIQ 123
Query: 445 SSGKNVTLLVCGKKAYDYFQAKKIPIVSSLADPLDTPPDSKEGIVVESNHDSHMAKER 502
SSGKNVTLLVCGKKAYDYFQAKKIPIVSSLADPLDTPPDSKEGIVVESNHDSHMAKER
Sbjct: 124 SSGKNVTLLVCGKKAYDYFQAKKIPIVSSLADPLDTPPDSKEGIVVESNHDSHMAKER 181
Score = 77.4 bits (189), Expect = 3e-14
Identities = 40/119 (33%), Positives = 66/119 (55%), Gaps = 11/119 (9%)
Query: 239 HQPRIVEMKKGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVET 298
H+P++ + KG NGYGF+L A G IK++ G PA+ AGL++ D+++ VNG +V
Sbjct: 53 HKPKLCRLAKGENGYGFHLNAIRGLPGSFIKEVQKGGPADLAGLEDEDVIIEVNGVNVLD 112
Query: 299 LDHDSVVEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVKEAPAPTP 357
++ VV+ I+ G +LLV K+ + Y+Q++++P S P TP
Sbjct: 113 EPYEKVVDRIQSSGKNVTLLVCGKKA-----------YDYFQAKKIPIVSSLADPLDTP 160
Score = 67.4 bits (163), Expect = 3e-11
Identities = 35/87 (40%), Positives = 54/87 (62%), Gaps = 1/87 (1%)
Query: 7 PRECKLSKQEGQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKE 66
P+ C+L+K E YGF L + G ++ V+K PA+ AGL+D D ++ +NGV V E
Sbjct: 55 PKLCRLAKGEN-GYGFHLNAIRGLPGSFIKEVQKGGPADLAGLEDEDVIIEVNGVNVLDE 113
Query: 67 EHMQVVDLVRKSGNSVTLLVLDGDSYE 93
+ +VVD ++ SG +VTLLV +Y+
Sbjct: 114 PYEKVVDRIQSSGKNVTLLVCGKKAYD 140
Score = 65.9 bits (159), Expect = 9e-11
Identities = 32/84 (38%), Positives = 51/84 (60%)
Query: 132 QPRLCYLVKEGGSYGFSLKTVQGKKGVYMTDITPQGVAMRAGVLADDHLIEVNGENVEDA 191
+P+LC L K YGF L ++G G ++ ++ G A AG+ +D +IEVNG NV D
Sbjct: 54 KPKLCRLAKGENGYGFHLNAIRGLPGSFIKEVQKGGPADLAGLEDEDVIIEVNGVNVLDE 113
Query: 192 SHEEVVEKVKKSGSRVMFLLVDKE 215
+E+VV++++ SG V L+ K+
Sbjct: 114 PYEKVVDRIQSSGKNVTLLVCGKK 137
>gi|21630285 PDZ domain containing 3 [Homo sapiens]
Length = 491
Score = 215 bits (547), Expect = 9e-56
Identities = 147/429 (34%), Positives = 219/429 (51%), Gaps = 38/429 (8%)
Query: 7 PRECKLSKQEGQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKE 66
PR C LSK+EG+++GF L+ E GH+V V+ + A++ GLQ+GDR+L +N V+ E
Sbjct: 47 PRFCLLSKEEGKSFGFHLQQELGRAGHVVCRVDPGTSAQRQGLQEGDRILAVNNDVVEHE 106
Query: 67 EHMQVVDLVRKSGNSVTLLVLDGDSYEKAVKTRVDLKELGQSQKEQGLSDNILSPVMNGG 126
++ VV +R S V L VL +++ A R L E D L P + G
Sbjct: 107 DYAVVVRRIRASSPRVLLTVLARHAHDVA---RAQLGE-----------DAHLCPTLGPG 152
Query: 127 VQTWTQPRLCYLVKEGGSYGFSLKTVQGKKGVYMTDITPQGVAMRAGVLADDHLIEVNGE 186
V+ PRLC++VK+ G +GFS+ G +G + ++ G A RAGV L+EVNG
Sbjct: 153 VR----PRLCHIVKDEGGFGFSV--THGNQGPFWLVLSTGGAAERAGVPPGARLLEVNG- 205
Query: 187 NVEDASHEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRETASLKLLPHQPRIVEM 246
+ +SG +V L+ E +++ + + A LP +PR + +
Sbjct: 206 -------------LWQSGQQVTLLVAGPEVEEQCRQLGLPLAAPLAEGWALPTKPRCLHL 252
Query: 247 KKGSNGYGFYLRAGSE---QKGQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVETLDHDS 303
+KG G+GF LR + GQ + ++D G PA++AG++ D +VAV GESVE L H+
Sbjct: 253 EKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAGMQAGDRLVAVAGESVEGLGHEE 312
Query: 304 VVEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVKEAPAPTPTSLEVS 363
V I+ G SL VVD E D + + SP L+ ++ E P + A + + S
Sbjct: 313 TVSRIQGQGSCVSLTVVDPEADRFFSMVRLSPLLFLENTEAPASPQGSSSASLVETEDPS 372
Query: 364 SPPDTTEEVDHKPKLCRLAKGENG-YGFHLNAIRGLPGSFIKEVQKGGPADLAGLEDEDV 422
+ V + C L G G YGF L+ + P FI +V GG A AGL+ DV
Sbjct: 373 LEDTSVPSVPLGSRQCFLYPGPGGSYGFRLSCVASGPRLFISQVTPGGSAARAGLQVGDV 432
Query: 423 IIEVNGVNV 431
I+EVNG V
Sbjct: 433 ILEVNGYPV 441
Score = 107 bits (267), Expect = 3e-23
Identities = 96/373 (25%), Positives = 159/373 (42%), Gaps = 54/373 (14%)
Query: 132 QPRLCYLVKEGG-SYGFSLKTVQGKKGVYMTDITPQGVAMRAGVLADDHLIEVNGENVED 190
+PR C L KE G S+GF L+ G+ G + + P A R G+ D ++ VN + VE
Sbjct: 46 RPRFCLLSKEEGKSFGFHLQQELGRAGHVVCRVDPGTSAQRQGLQEGDRILAVNNDVVEH 105
Query: 191 ASHEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRETASLKLLPH--QPRIVEMKK 248
+ VV +++ S RV+ ++ + H + Q + L +PR+ + K
Sbjct: 106 EDYAVVVRRIRASSPRVLLTVLARHA---HDVARAQLGEDAHLCPTLGPGVRPRLCHIVK 162
Query: 249 GSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVETLDHDSVVEMI 308
G+GF + G++ ++ + +G AE AG+ ++ VNG +
Sbjct: 163 DEGGFGFSVTHGNQGPFWLV--LSTGGAAERAGVPPGARLLEVNG--------------L 206
Query: 309 RKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVKEAPAPTPTSLEVSSPPDT 368
+ G Q +LLV E + R L +++P
Sbjct: 207 WQSGQQVTLLVAGPEVEEQCR---------------------------QLGLPLAAPLAE 239
Query: 369 TEEVDHKPKLCRLAKGENGYGFHLNAIRGL---PGSFIKEVQKGGPADLAGLEDEDVIIE 425
+ KP+ L KG G+GF L +GL PG F+ EV G PA AG++ D ++
Sbjct: 240 GWALPTKPRCLHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAGMQAGDRLVA 299
Query: 426 VNGVNVLDEPYEKVVDRIQSSGKNVTLLVCGKKAYDYFQAKKIPIVSSL--ADPLDTPPD 483
V G +V +E+ V RIQ G V+L V +A +F ++ + L + +P
Sbjct: 300 VAGESVEGLGHEETVSRIQGQGSCVSLTVVDPEADRFFSMVRLSPLLFLENTEAPASPQG 359
Query: 484 SKEGIVVESNHDS 496
S +VE+ S
Sbjct: 360 SSSASLVETEDPS 372
Score = 79.7 bits (195), Expect = 6e-15
Identities = 59/200 (29%), Positives = 99/200 (49%), Gaps = 14/200 (7%)
Query: 18 QNYGFFLRIEKDTEGH---LVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDL 74
Q +GF LR EK +G + V+ PA+KAG+Q GDR++ + G V+ H + V
Sbjct: 257 QGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAGMQAGDRLVAVAGESVEGLGHEETVSR 316
Query: 75 VRKSGNSVTLLVLDGDSYEKAVKTRVD----LKELGQSQKEQGLSDNILSPVMNGGVQTW 130
++ G+ V+L V+D ++ R+ L+ QG S L + ++
Sbjct: 317 IQGQGSCVSLTVVDPEADRFFSMVRLSPLLFLENTEAPASPQGSSSASLVETEDPSLEDT 376
Query: 131 TQP------RLCYLVK-EGGSYGFSLKTVQGKKGVYMTDITPQGVAMRAGVLADDHLIEV 183
+ P R C+L GGSYGF L V ++++ +TP G A RAG+ D ++EV
Sbjct: 377 SVPSVPLGSRQCFLYPGPGGSYGFRLSCVASGPRLFISQVTPGGSAARAGLQVGDVILEV 436
Query: 184 NGENVEDASHEEVVEKVKKS 203
NG V + E ++++ ++
Sbjct: 437 NGYPVGGQNDLERLQQLPEA 456
Score = 33.1 bits (74), Expect = 0.63
Identities = 20/63 (31%), Positives = 29/63 (46%)
Query: 8 RECKLSKQEGQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKEE 67
R+C L G +YGF L + V A +AGLQ GD +L +NG V +
Sbjct: 386 RQCFLYPGPGGSYGFRLSCVASGPRLFISQVTPGGSAARAGLQVGDVILEVNGYPVGGQN 445
Query: 68 HMQ 70
++
Sbjct: 446 DLE 448
>gi|4759140 sodium/hydrogen exchanger regulatory factor 1 [Homo
sapiens]
Length = 358
Score = 162 bits (410), Expect = 7e-40
Identities = 105/294 (35%), Positives = 149/294 (50%), Gaps = 49/294 (16%)
Query: 133 PRLCYLVKEGGSYGFSLKTVQGKKGVYMTDITPQGVAMRAGVLADDHLIEVNGENVEDAS 192
PRLC L K YGF L +GK G Y+ + P A +AG+LA D L+EVNGENVE +
Sbjct: 12 PRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKET 71
Query: 193 HEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRETASLKLLPHQ------------ 240
H++VV +++ + + V L+VD ETD++ + +Q + E + P Q
Sbjct: 72 HQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQAEPPAAAEVQGA 131
Query: 241 --------------------PRIVEMKKGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEA 280
PR+ MKKG +GYGF L + + GQ I+ +D SPAE +
Sbjct: 132 GNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKSKPGQFIRSVDPDSPAEAS 191
Query: 281 GLKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQ 340
GL+ D +V VNG +E H VV IR GGD+T LLVVD+ETD ++ P +
Sbjct: 192 GLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFKKCRVIPSQEHL 251
Query: 341 SQELP----NGSVK---------EAPAPTP-TSLEVSSPPDTTEEV---DHKPK 377
+ LP NG ++ EA +P +L S+ DT+EE+ D PK
Sbjct: 252 NGPLPVPFTNGEIQKENSREALAEAALESPRPALVRSASSDTSEELNSQDSPPK 305
Score = 151 bits (382), Expect = 1e-36
Identities = 98/291 (33%), Positives = 153/291 (52%), Gaps = 14/291 (4%)
Query: 241 PRIVEMKKGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVETLD 300
PR+ ++KG NGYGF+L + GQ I+ ++ GSPAE+AGL D +V VNGE+VE
Sbjct: 12 PRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKET 71
Query: 301 HDSVVEMIRKGGDQTSLLVVDKETD-NMYRLAHFSPFLYYQSQELPNGSVKEAPAPTPTS 359
H VV IR + LLVVD ETD + +L ++QE P + A A +
Sbjct: 72 HQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQAEPPAAAEVQGA 131
Query: 360 LEVSSPPDT----TEEVDHKPKLCRLAKGENGYGFHLNAIRGLPGSFIKEVQKGGPADLA 415
+ P + E+ + +P+LC + KG +GYGF+L++ + PG FI+ V PA+ +
Sbjct: 132 GNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKSKPGQFIRSVDPDSPAEAS 191
Query: 416 GLEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTLLVCGKKAYDYF-QAKKIPIVSSL 474
GL +D I+EVNGV + + + VV I++ G LLV ++ ++F + + IP L
Sbjct: 192 GLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFKKCRVIPSQEHL 251
Query: 475 ADPLDTP--------PDSKEGIVVESNHDSHMAKERAHSTASHSSSNSEDT 517
PL P +S+E + + A R+ S+ + NS+D+
Sbjct: 252 NGPLPVPFTNGEIQKENSREALAEAALESPRPALVRSASSDTSEELNSQDS 302
Score = 134 bits (336), Expect = 3e-31
Identities = 84/228 (36%), Positives = 125/228 (54%), Gaps = 18/228 (7%)
Query: 7 PRECKLSKQEGQN-YGFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDK 65
PR C L K G N YGF L EK G +R+VE SPAEKAGL GDR++ +NG V+K
Sbjct: 12 PRLCCLEK--GPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEK 69
Query: 66 EEHMQVVDLVRKSGNSVTLLVLDGDSYEKAVKTRVDLK-ELGQSQKEQGLSDNILSPVMN 124
E H QVV +R + N+V LLV+D ++ E+ K V ++ EL ++Q+ G ++ + +
Sbjct: 70 ETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQAEPPAAAEVQ 129
Query: 125 GG--------------VQTWTQPRLCYLVKEGGSYGFSLKTVQGKKGVYMTDITPQGVAM 170
G Q +PRLC + K YGF+L + + K G ++ + P A
Sbjct: 130 GAGNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKSKPGQFIRSVDPDSPAE 189
Query: 171 RAGVLADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLVDKETDK 218
+G+ A D ++EVNG +E H +VV ++ G L+VD+ETD+
Sbjct: 190 ASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDE 237
Score = 68.2 bits (165), Expect = 2e-11
Identities = 41/122 (33%), Positives = 64/122 (52%), Gaps = 8/122 (6%)
Query: 7 PRECKLSKQEGQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKE 66
PR C + K YGF L +K G +R V+ SPAE +GL+ DR++ +NGV ++ +
Sbjct: 152 PRLCTMKKGPS-GYGFNLHSDKSKPGQFIRSVDPDSPAEASGLRAQDRIVEVNGVCMEGK 210
Query: 67 EHMQVVDLVRKSGNSVTLLVLDGDSYEKAVKTRVDLKELGQSQKEQGLSDNILSPVMNGG 126
+H VV +R G+ LLV+D ++ E K RV ++ L+ + P NG
Sbjct: 211 QHGDVVSAIRAGGDETKLLVVDRETDEFFKKCRV-------IPSQEHLNGPLPVPFTNGE 263
Query: 127 VQ 128
+Q
Sbjct: 264 IQ 265
>gi|194018553 solute carrier family 9 isoform 3 regulator 2 isoform
a [Homo sapiens]
Length = 337
Score = 141 bits (355), Expect = 2e-33
Identities = 93/287 (32%), Positives = 142/287 (49%), Gaps = 13/287 (4%)
Query: 238 PHQPRIVEMKKGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVE 297
P +PR+ + +G GYGF+L ++GQ I+ ++ GSPAE A L+ D +V VNG +VE
Sbjct: 6 PLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVE 65
Query: 298 TLDHDSVVEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVKEAPAPTP 357
H VV+ I+ QT LLVVD+ETD R + + LP P P
Sbjct: 66 GETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDW 125
Query: 358 TSLEVSSPPDTTEEV-----DHKPKLCRLAKGENGYGFHLNAIRGLPGSFIKEVQKGGPA 412
S ++V + +P+LC L KG GYGF+L++ + PG +I+ V G PA
Sbjct: 126 AHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPA 185
Query: 413 DLAGLEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTLLVCGKKAYDYFQAKKI-PIV 471
+GL +D +IEVNG NV + +VV I++ LLV + ++F+ ++ P
Sbjct: 186 ARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTE 245
Query: 472 SSLADPLDTPPDSKEGIVVESNHDSHMAKERAHSTASHSSSNSEDTE 518
+ PL +P V + + A S+ S + +DTE
Sbjct: 246 EHVEGPLPSP-------VTNGTSPAQLNGGSACSSRSDLPGSDKDTE 285
Score = 139 bits (349), Expect = 8e-33
Identities = 81/247 (32%), Positives = 124/247 (50%), Gaps = 32/247 (12%)
Query: 132 QPRLCYLVKEGGSYGFSLKTVQGKKGVYMTDITPQGVAMRAGVLADDHLIEVNGENVEDA 191
+PRLC LV+ YGF L +G++G ++ + P A A + A D L+EVNG NVE
Sbjct: 8 RPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGE 67
Query: 192 SHEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRETASLKLLPH------------ 239
+H +VV+++K + L+VD+ETD+ +++ E A L P
Sbjct: 68 THHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAH 127
Query: 240 --------------------QPRIVEMKKGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEE 279
+PR+ ++KG GYGF L + + GQ I+ +D GSPA
Sbjct: 128 TGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAAR 187
Query: 280 AGLKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYY 339
+GL+ D ++ VNG++VE L H VV I+ D+ LLVVD ETD ++ +P +
Sbjct: 188 SGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEEH 247
Query: 340 QSQELPN 346
LP+
Sbjct: 248 VEGPLPS 254
Score = 128 bits (322), Expect = 1e-29
Identities = 83/234 (35%), Positives = 116/234 (49%), Gaps = 30/234 (12%)
Query: 7 PRECKLSKQEGQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKE 66
PR C+L + E Q YGF L EK G +R VE SPAE A L+ GDR++ +NGV V+ E
Sbjct: 9 PRLCRLVRGE-QGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGE 67
Query: 67 EHMQVVDLVRKSGNSVTLLVLDGDSYEKAVKTRV----------------------DLKE 104
H QVV ++ LLV+D ++ E+ + ++ D
Sbjct: 68 THHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAH 127
Query: 105 LGQSQKEQGLSDNILSPVMNGGVQTWTQPRLCYLVKEGGSYGFSLKTVQGKKGVYMTDIT 164
G E G D + P+ +PRLC+L K YGF+L + + + G Y+ +
Sbjct: 128 TGSHSSEAGKKD-VSGPLRE------LRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVD 180
Query: 165 PQGVAMRAGVLADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLVDKETDK 218
P A R+G+ A D LIEVNG+NVE H EVV +K L+VD ETD+
Sbjct: 181 PGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDE 234
Score = 62.4 bits (150), Expect = 1e-09
Identities = 40/119 (33%), Positives = 62/119 (52%), Gaps = 8/119 (6%)
Query: 7 PRECKLSKQEGQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKE 66
PR C L K Q YGF L +K G +R V+ SPA ++GL+ DR++ +NG V+
Sbjct: 149 PRLCHLRKGP-QGYGFNLHSDKSRPGQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGL 207
Query: 67 EHMQVVDLVRKSGNSVTLLVLDGDSYEKAVKTRVDLKELGQSQKEQGLSDNILSPVMNG 125
H +VV ++ + LLV+D ++ E + RV + E+ + + SPV NG
Sbjct: 208 RHAEVVASIKAREDEARLLVVDPETDEHFKRLRV-------TPTEEHVEGPLPSPVTNG 259
>gi|71897229 solute carrier family 9 isoform 3 regulator 2 isoform b
[Homo sapiens]
Length = 326
Score = 141 bits (355), Expect = 2e-33
Identities = 93/287 (32%), Positives = 142/287 (49%), Gaps = 13/287 (4%)
Query: 238 PHQPRIVEMKKGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVE 297
P +PR+ + +G GYGF+L ++GQ I+ ++ GSPAE A L+ D +V VNG +VE
Sbjct: 6 PLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVE 65
Query: 298 TLDHDSVVEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVKEAPAPTP 357
H VV+ I+ QT LLVVD+ETD R + + LP P P
Sbjct: 66 GETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDW 125
Query: 358 TSLEVSSPPDTTEEV-----DHKPKLCRLAKGENGYGFHLNAIRGLPGSFIKEVQKGGPA 412
S ++V + +P+LC L KG GYGF+L++ + PG +I+ V G PA
Sbjct: 126 AHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPA 185
Query: 413 DLAGLEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTLLVCGKKAYDYFQAKKI-PIV 471
+GL +D +IEVNG NV + +VV I++ LLV + ++F+ ++ P
Sbjct: 186 ARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTE 245
Query: 472 SSLADPLDTPPDSKEGIVVESNHDSHMAKERAHSTASHSSSNSEDTE 518
+ PL +P V + + A S+ S + +DTE
Sbjct: 246 EHVEGPLPSP-------VTNGTSPAQLNGGSACSSRSDLPGSDKDTE 285
Score = 139 bits (349), Expect = 8e-33
Identities = 81/247 (32%), Positives = 124/247 (50%), Gaps = 32/247 (12%)
Query: 132 QPRLCYLVKEGGSYGFSLKTVQGKKGVYMTDITPQGVAMRAGVLADDHLIEVNGENVEDA 191
+PRLC LV+ YGF L +G++G ++ + P A A + A D L+EVNG NVE
Sbjct: 8 RPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGE 67
Query: 192 SHEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRETASLKLLPH------------ 239
+H +VV+++K + L+VD+ETD+ +++ E A L P
Sbjct: 68 THHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAH 127
Query: 240 --------------------QPRIVEMKKGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEE 279
+PR+ ++KG GYGF L + + GQ I+ +D GSPA
Sbjct: 128 TGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAAR 187
Query: 280 AGLKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYY 339
+GL+ D ++ VNG++VE L H VV I+ D+ LLVVD ETD ++ +P +
Sbjct: 188 SGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEEH 247
Query: 340 QSQELPN 346
LP+
Sbjct: 248 VEGPLPS 254
Score = 128 bits (322), Expect = 1e-29
Identities = 83/234 (35%), Positives = 116/234 (49%), Gaps = 30/234 (12%)
Query: 7 PRECKLSKQEGQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKE 66
PR C+L + E Q YGF L EK G +R VE SPAE A L+ GDR++ +NGV V+ E
Sbjct: 9 PRLCRLVRGE-QGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGE 67
Query: 67 EHMQVVDLVRKSGNSVTLLVLDGDSYEKAVKTRV----------------------DLKE 104
H QVV ++ LLV+D ++ E+ + ++ D
Sbjct: 68 THHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAH 127
Query: 105 LGQSQKEQGLSDNILSPVMNGGVQTWTQPRLCYLVKEGGSYGFSLKTVQGKKGVYMTDIT 164
G E G D + P+ +PRLC+L K YGF+L + + + G Y+ +
Sbjct: 128 TGSHSSEAGKKD-VSGPLRE------LRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVD 180
Query: 165 PQGVAMRAGVLADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLVDKETDK 218
P A R+G+ A D LIEVNG+NVE H EVV +K L+VD ETD+
Sbjct: 181 PGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDE 234
Score = 62.4 bits (150), Expect = 1e-09
Identities = 40/119 (33%), Positives = 62/119 (52%), Gaps = 8/119 (6%)
Query: 7 PRECKLSKQEGQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKE 66
PR C L K Q YGF L +K G +R V+ SPA ++GL+ DR++ +NG V+
Sbjct: 149 PRLCHLRKGP-QGYGFNLHSDKSRPGQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGL 207
Query: 67 EHMQVVDLVRKSGNSVTLLVLDGDSYEKAVKTRVDLKELGQSQKEQGLSDNILSPVMNG 125
H +VV ++ + LLV+D ++ E + RV + E+ + + SPV NG
Sbjct: 208 RHAEVVASIKAREDEARLLVVDPETDEHFKRLRV-------TPTEEHVEGPLPSPVTNG 259
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 97.8 bits (242), Expect = 2e-20
Identities = 85/334 (25%), Positives = 153/334 (45%), Gaps = 49/334 (14%)
Query: 158 VYMTDITPQGVAMRAGVL-ADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLVDKET 216
+++T I P G A + G L +D ++ VN +V + +H VE +K++GS V ++ ++
Sbjct: 137 IFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRK- 195
Query: 217 DKRHVEQKIQFKRETASLKLLPHQPRIVEMK--KGSNGYGFYLRAG-------SEQKGQI 267
P +++E+K KG G GF + G + +
Sbjct: 196 ---------------------PPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYV 234
Query: 268 IKDIDSGSPAEEAGLKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLVVDKETDNM 327
K I+ G+ ++ L+ D ++AVN +E + H+ V ++ D L V + N
Sbjct: 235 TKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVA--KPSNA 292
Query: 328 YRLAHFSP------FLYYQSQELPNGSVKEAPAPT---PTSLEVSSPPDTT----EEVDH 374
Y ++P + + E+ + S PT PTS SP E++
Sbjct: 293 YLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPR 352
Query: 375 KPKLCRLAKGENGYGFHLNAIRGLPGSFIKEVQKGGPADLAG-LEDEDVIIEVNGVNVLD 433
+P+ + +G G GF++ G FI + GGPADL+G L D I+ VNGV++ +
Sbjct: 353 EPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRN 412
Query: 434 EPYEKVVDRIQSSGKNVTLLVCGK-KAYDYFQAK 466
+E+ ++++G+ VT++ K + Y F+AK
Sbjct: 413 ASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAK 446
Score = 68.2 bits (165), Expect = 2e-11
Identities = 74/370 (20%), Positives = 147/370 (39%), Gaps = 77/370 (20%)
Query: 26 IEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDLVRKSGNSVTLL 85
I D + +++ + A+ L+ D +L +N V V + H V+ ++++G+ V L
Sbjct: 131 IGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLY 190
Query: 86 VLDGDSYEKAVKTRVDLKELGQSQKEQGLSDNILSPVMNGGVQTWTQPRLCYLVKEGGSY 145
V+ + V E+ + +GL +I V N
Sbjct: 191 VMRRKPPAEKVM------EIKLIKGPKGLGFSIAGGVGN--------------------- 223
Query: 146 GFSLKTVQGKKGVYMTDITPQGVAMRAGVLA-DDHLIEVNGENVEDASHEEVVEKVKKSG 204
+ + G +Y+T I G A + G L D ++ VN +ED HE+ V +K +
Sbjct: 224 ----QHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTY 279
Query: 205 SRVMFLLVDKETD----------------KRHVEQKIQFK-------------------- 228
V++L V K ++ +H++ +I
Sbjct: 280 D-VVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYS 338
Query: 229 ---RETASLKLLPHQPRIVEMKKGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEAG-LKN 284
++ + +P +PR + + +GS G GF + G + +G I I +G PA+ +G L+
Sbjct: 339 PVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRK 398
Query: 285 NDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQEL 344
D +++VNG + H+ ++ G +++ K + + F ++ ++L
Sbjct: 399 GDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEE----YSRFEAKIHDLREQL 454
Query: 345 PNGSVKEAPA 354
N S+ A
Sbjct: 455 MNSSLGSGTA 464
Score = 51.6 bits (122), Expect = 2e-06
Identities = 62/266 (23%), Positives = 104/266 (39%), Gaps = 45/266 (16%)
Query: 26 IEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDLVRKSGNSVTLL 85
I D ++ +++E + + LQ GD++L +N V ++ H V ++ + + V L
Sbjct: 226 IPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLK 285
Query: 86 VLD------GDSYEKAVKTRVDLKELGQSQKEQGL------------SDNILSPVMN--- 124
V DSY T + L S SPV
Sbjct: 286 VAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLL 345
Query: 125 GGVQTWTQPRLCYLVKEGGSYGFSLKTVQGKKGVYMTDITPQGVAMRAGVLAD-DHLIEV 183
G +PR + + GF++ + +G++++ I G A +G L D ++ V
Sbjct: 346 GEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSV 405
Query: 184 NGENVEDASHEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRE----------TAS 233
NG ++ +ASHE+ +K +G V + K + E KI RE TAS
Sbjct: 406 NGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTAS 465
Query: 234 LKLLPHQPRIVEMKKGSNGYGFYLRA 259
L+ P + GFY+RA
Sbjct: 466 LRSNPKR-------------GFYIRA 478
Score = 37.7 bits (86), Expect = 0.026
Identities = 20/66 (30%), Positives = 37/66 (56%), Gaps = 1/66 (1%)
Query: 21 GFFLRIEKDTEGHLVRVVEKCSPAEKAG-LQDGDRVLRINGVFVDKEEHMQVVDLVRKSG 79
GF + +D EG + + PA+ +G L+ GD++L +NGV + H Q ++ +G
Sbjct: 367 GFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAG 426
Query: 80 NSVTLL 85
+VT++
Sbjct: 427 QTVTII 432
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 97.8 bits (242), Expect = 2e-20
Identities = 85/334 (25%), Positives = 153/334 (45%), Gaps = 49/334 (14%)
Query: 158 VYMTDITPQGVAMRAGVL-ADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLVDKET 216
+++T I P G A + G L +D ++ VN +V + +H VE +K++GS V ++ ++
Sbjct: 91 IFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRK- 149
Query: 217 DKRHVEQKIQFKRETASLKLLPHQPRIVEMK--KGSNGYGFYLRAG-------SEQKGQI 267
P +++E+K KG G GF + G + +
Sbjct: 150 ---------------------PPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYV 188
Query: 268 IKDIDSGSPAEEAGLKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLVVDKETDNM 327
K I+ G+ ++ L+ D ++AVN +E + H+ V ++ D L V + N
Sbjct: 189 TKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVA--KPSNA 246
Query: 328 YRLAHFSP------FLYYQSQELPNGSVKEAPAPT---PTSLEVSSPPDTT----EEVDH 374
Y ++P + + E+ + S PT PTS SP E++
Sbjct: 247 YLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPR 306
Query: 375 KPKLCRLAKGENGYGFHLNAIRGLPGSFIKEVQKGGPADLAG-LEDEDVIIEVNGVNVLD 433
+P+ + +G G GF++ G FI + GGPADL+G L D I+ VNGV++ +
Sbjct: 307 EPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRN 366
Query: 434 EPYEKVVDRIQSSGKNVTLLVCGK-KAYDYFQAK 466
+E+ ++++G+ VT++ K + Y F+AK
Sbjct: 367 ASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAK 400
Score = 68.2 bits (165), Expect = 2e-11
Identities = 74/370 (20%), Positives = 147/370 (39%), Gaps = 77/370 (20%)
Query: 26 IEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDLVRKSGNSVTLL 85
I D + +++ + A+ L+ D +L +N V V + H V+ ++++G+ V L
Sbjct: 85 IGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLY 144
Query: 86 VLDGDSYEKAVKTRVDLKELGQSQKEQGLSDNILSPVMNGGVQTWTQPRLCYLVKEGGSY 145
V+ + V E+ + +GL +I V N
Sbjct: 145 VMRRKPPAEKVM------EIKLIKGPKGLGFSIAGGVGN--------------------- 177
Query: 146 GFSLKTVQGKKGVYMTDITPQGVAMRAGVLA-DDHLIEVNGENVEDASHEEVVEKVKKSG 204
+ + G +Y+T I G A + G L D ++ VN +ED HE+ V +K +
Sbjct: 178 ----QHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTY 233
Query: 205 SRVMFLLVDKETD----------------KRHVEQKIQFK-------------------- 228
V++L V K ++ +H++ +I
Sbjct: 234 D-VVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYS 292
Query: 229 ---RETASLKLLPHQPRIVEMKKGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEAG-LKN 284
++ + +P +PR + + +GS G GF + G + +G I I +G PA+ +G L+
Sbjct: 293 PVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRK 352
Query: 285 NDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQEL 344
D +++VNG + H+ ++ G +++ K + + F ++ ++L
Sbjct: 353 GDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEE----YSRFEAKIHDLREQL 408
Query: 345 PNGSVKEAPA 354
N S+ A
Sbjct: 409 MNSSLGSGTA 418
Score = 51.6 bits (122), Expect = 2e-06
Identities = 62/266 (23%), Positives = 104/266 (39%), Gaps = 45/266 (16%)
Query: 26 IEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDLVRKSGNSVTLL 85
I D ++ +++E + + LQ GD++L +N V ++ H V ++ + + V L
Sbjct: 180 IPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLK 239
Query: 86 VLD------GDSYEKAVKTRVDLKELGQSQKEQGL------------SDNILSPVMN--- 124
V DSY T + L S SPV
Sbjct: 240 VAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLL 299
Query: 125 GGVQTWTQPRLCYLVKEGGSYGFSLKTVQGKKGVYMTDITPQGVAMRAGVLAD-DHLIEV 183
G +PR + + GF++ + +G++++ I G A +G L D ++ V
Sbjct: 300 GEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSV 359
Query: 184 NGENVEDASHEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRE----------TAS 233
NG ++ +ASHE+ +K +G V + K + E KI RE TAS
Sbjct: 360 NGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTAS 419
Query: 234 LKLLPHQPRIVEMKKGSNGYGFYLRA 259
L+ P + GFY+RA
Sbjct: 420 LRSNPKR-------------GFYIRA 432
Score = 37.7 bits (86), Expect = 0.026
Identities = 20/66 (30%), Positives = 37/66 (56%), Gaps = 1/66 (1%)
Query: 21 GFFLRIEKDTEGHLVRVVEKCSPAEKAG-LQDGDRVLRINGVFVDKEEHMQVVDLVRKSG 79
GF + +D EG + + PA+ +G L+ GD++L +NGV + H Q ++ +G
Sbjct: 321 GFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAG 380
Query: 80 NSVTLL 85
+VT++
Sbjct: 381 QTVTII 386
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 94.0 bits (232), Expect = 3e-19
Identities = 93/377 (24%), Positives = 165/377 (43%), Gaps = 49/377 (12%)
Query: 115 SDNILSPVMNGGVQTWTQPRLCYLVKEGGSYGFSLKT------VQGKKGVYMTDITPQGV 168
+D++ +P G + L + GFS+ + +++T I G
Sbjct: 204 TDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGA 263
Query: 169 AMRAGVL-ADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQF 227
A + G L +D ++ VN +V D +H + VE +K++GS V ++
Sbjct: 264 AAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIV----------------RLYV 307
Query: 228 KRETASLKLLPHQPRIVEMK--KGSNGYGFYLRAG-------SEQKGQIIKDIDSGSPAE 278
KR P +I+E+K KG G GF + G + + K I+ G+ +
Sbjct: 308 KRRK------PVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHK 361
Query: 279 EAGLKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLVVDKETDNMYRLAHFSP--F 336
+ L+ D ++AVN +E + H+ V ++ D L V + +MY ++P
Sbjct: 362 DGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVA--KPTSMYMNDGYAPPDI 419
Query: 337 LYYQSQEL-----PNGSVKEAPAPTPTSLEVSSPPDTTEEVDHKPKLCRLAKGENGYGFH 391
SQ + P+ + + PA VS +E+ +P+ L +G G GF+
Sbjct: 420 TNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFN 479
Query: 392 LNAIRGLPGSFIKEVQKGGPADLAG-LEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNV 450
+ G FI + GGPADL+G L D II VN V++ +E+ ++++G+ V
Sbjct: 480 IVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAV 539
Query: 451 TLLVCGK-KAYDYFQAK 466
T++ + + Y F+AK
Sbjct: 540 TIVAQYRPEEYSRFEAK 556
Score = 57.8 bits (138), Expect = 2e-08
Identities = 65/289 (22%), Positives = 119/289 (41%), Gaps = 25/289 (8%)
Query: 26 IEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDLVRKSGNSVTLL 85
I D ++ +++E + + LQ GD++L +N V +++ H + V ++ + + V L
Sbjct: 342 IPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLK 401
Query: 86 VL--------DG-------DSYEKAVKTRVDLKE-LGQSQKEQGLSDNILSPVMNGGVQT 129
V DG +S + V V LGQ+ + V+ G +
Sbjct: 402 VAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVL-GDDEI 460
Query: 130 WTQPRLCYLVKEGGSYGFSLKTVQGKKGVYMTDITPQGVAMRAGVL-ADDHLIEVNGENV 188
+PR L + GF++ + +G++++ I G A +G L D +I VN ++
Sbjct: 461 TREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDL 520
Query: 189 EDASHEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRETASLKLLPHQPRIVEMKK 248
ASHE+ +K +G V + + + E KI RE + + +
Sbjct: 521 RAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSL---R 577
Query: 249 GSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVE 297
S Y+RA + K DSG P++ K D++ +N E
Sbjct: 578 TSQKRSLYVRALFDYD----KTKDSGLPSQGLNFKFGDILHVINASDDE 622
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 94.0 bits (232), Expect = 3e-19
Identities = 93/377 (24%), Positives = 165/377 (43%), Gaps = 49/377 (12%)
Query: 115 SDNILSPVMNGGVQTWTQPRLCYLVKEGGSYGFSLKT------VQGKKGVYMTDITPQGV 168
+D++ +P G + L + GFS+ + +++T I G
Sbjct: 204 TDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGA 263
Query: 169 AMRAGVL-ADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQF 227
A + G L +D ++ VN +V D +H + VE +K++GS V ++
Sbjct: 264 AAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIV----------------RLYV 307
Query: 228 KRETASLKLLPHQPRIVEMK--KGSNGYGFYLRAG-------SEQKGQIIKDIDSGSPAE 278
KR P +I+E+K KG G GF + G + + K I+ G+ +
Sbjct: 308 KRRK------PVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHK 361
Query: 279 EAGLKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLVVDKETDNMYRLAHFSP--F 336
+ L+ D ++AVN +E + H+ V ++ D L V + +MY ++P
Sbjct: 362 DGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVA--KPTSMYMNDGYAPPDI 419
Query: 337 LYYQSQEL-----PNGSVKEAPAPTPTSLEVSSPPDTTEEVDHKPKLCRLAKGENGYGFH 391
SQ + P+ + + PA VS +E+ +P+ L +G G GF+
Sbjct: 420 TNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFN 479
Query: 392 LNAIRGLPGSFIKEVQKGGPADLAG-LEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNV 450
+ G FI + GGPADL+G L D II VN V++ +E+ ++++G+ V
Sbjct: 480 IVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAV 539
Query: 451 TLLVCGK-KAYDYFQAK 466
T++ + + Y F+AK
Sbjct: 540 TIVAQYRPEEYSRFEAK 556
Score = 57.8 bits (138), Expect = 2e-08
Identities = 65/289 (22%), Positives = 119/289 (41%), Gaps = 25/289 (8%)
Query: 26 IEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDLVRKSGNSVTLL 85
I D ++ +++E + + LQ GD++L +N V +++ H + V ++ + + V L
Sbjct: 342 IPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLK 401
Query: 86 VL--------DG-------DSYEKAVKTRVDLKE-LGQSQKEQGLSDNILSPVMNGGVQT 129
V DG +S + V V LGQ+ + V+ G +
Sbjct: 402 VAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVL-GDDEI 460
Query: 130 WTQPRLCYLVKEGGSYGFSLKTVQGKKGVYMTDITPQGVAMRAGVL-ADDHLIEVNGENV 188
+PR L + GF++ + +G++++ I G A +G L D +I VN ++
Sbjct: 461 TREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDL 520
Query: 189 EDASHEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRETASLKLLPHQPRIVEMKK 248
ASHE+ +K +G V + + + E KI RE + + +
Sbjct: 521 RAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSL---R 577
Query: 249 GSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVE 297
S Y+RA + K DSG P++ K D++ +N E
Sbjct: 578 TSQKRSLYVRALFDYD----KTKDSGLPSQGLNFKFGDILHVINASDDE 622
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 89.0 bits (219), Expect = 1e-17
Identities = 78/338 (23%), Positives = 145/338 (42%), Gaps = 48/338 (14%)
Query: 157 GVYMTDITPQGVAMRAGVLA-DDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLVDKE 215
G+++T I P G A G L +D ++ VN +V + H VE +K++G V ++ ++
Sbjct: 159 GIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQ 218
Query: 216 TDKRHVEQKIQFKRETASLKLLPHQPRIVEMKKGSNGYGFYLRAG-------SEQKGQII 268
+ + V + KG G GF + G + I
Sbjct: 219 PPPETIME--------------------VNLLKGPKGLGFSIAGGIGNQHIPGDNSIYIT 258
Query: 269 KDIDSGSPAEEAGLKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLVVDKET---D 325
K I+ G+ ++ L+ D ++AVN +++ + H+ V ++ D L V + +
Sbjct: 259 KIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLN 318
Query: 326 NMYRLAHF-SPFLYYQSQELPNGSVKEAPAPTPTSLEVSSPPDTT--------------E 370
+MY + S F + + S + + +PP E
Sbjct: 319 DMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEE 378
Query: 371 EVDHKPKLCRLAKGENGYGFHLNAIRGLPGSFIKEVQKGGPADLAG-LEDEDVIIEVNGV 429
+ +P+ L KG G GF++ G F+ + GGPADL+G L D I+ VNGV
Sbjct: 379 DFTREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGV 438
Query: 430 NVLDEPYEKVVDRIQSSGKNVTLLVCGK-KAYDYFQAK 466
N+ + +E+ ++ +G++VT++ + + Y F++K
Sbjct: 439 NLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESK 476
Score = 49.7 bits (117), Expect = 7e-06
Identities = 51/234 (21%), Positives = 94/234 (40%), Gaps = 29/234 (12%)
Query: 26 IEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDLVRKSGNSVTLL 85
I D ++ +++E + + LQ GDR+L +N + H + V ++ + + V L
Sbjct: 249 IPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLK 308
Query: 86 VLD------GDSY-------------EKAVKTRVDLKELGQSQKEQG------LSDNILS 120
V D Y + + L LG + + + S
Sbjct: 309 VAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYPAPPQVPPTRYS 368
Query: 121 PV---MNGGVQTWTQPRLCYLVKEGGSYGFSLKTVQGKKGVYMTDITPQGVAMRAGVLA- 176
P+ M +PR L K GF++ + +G++++ I G A +G L
Sbjct: 369 PIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRR 428
Query: 177 DDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRE 230
D ++ VNG N+ +A+HE+ +K++G V + + + E KI RE
Sbjct: 429 GDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLRE 482
Score = 42.0 bits (97), Expect = 0.001
Identities = 28/83 (33%), Positives = 44/83 (53%), Gaps = 2/83 (2%)
Query: 4 TFNPRECKLSKQEGQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAG-LQDGDRVLRINGVF 62
T PR+ L K GF + +D EG V + PA+ +G L+ GDR+L +NGV
Sbjct: 381 TREPRKIILHKGS-TGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVN 439
Query: 63 VDKEEHMQVVDLVRKSGNSVTLL 85
+ H Q ++++G SVT++
Sbjct: 440 LRNATHEQAAAALKRAGQSVTIV 462
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 87.4 bits (215), Expect = 3e-17
Identities = 89/356 (25%), Positives = 149/356 (41%), Gaps = 68/356 (19%)
Query: 157 GVYMTDITPQGVAMRAGVL-ADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLVDKE 215
G+++T I P G A G L +D ++ VN +V + SH + VE +K++GS V
Sbjct: 75 GIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIV-------- 126
Query: 216 TDKRHVEQKIQFKRETASLKLLPHQPRIVEMKKGSNGYGFYLRAG-------SEQKGQII 268
+ +V ++ +KL KG G GF + G + +
Sbjct: 127 --RLYVRRRRPILETVVEIKLF----------KGPKGLGFSIAGGVGNQHIPGDNSIYVT 174
Query: 269 KDIDSGSPAEEAGLKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLVVDKETDNMY 328
K ID G+ ++ L+ D ++ VN S+E + H+ V ++ K + L V K T +Y
Sbjct: 175 KIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAIL-KNTSEVVYLKVGKPT-TIY 232
Query: 329 RLAHFSPFLYYQSQELP---------NGSVKEAPAPTPTSLEVSSP--------PDTTEE 371
+ P S P NG+++ + P S SP D T
Sbjct: 233 MTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSH 292
Query: 372 VDH-------------------KPKLCRLAKGENGYGFHLNAIRGLPGSFIKEVQKGGPA 412
H +P+ L KG G GF++ G F+ + GGPA
Sbjct: 293 SQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPA 352
Query: 413 DLAG-LEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTLLV-CGKKAYDYFQAK 466
DL+G L+ D I+ VNG+++ +E+ ++ +G+ VT++ + Y F+AK
Sbjct: 353 DLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAK 408
Score = 58.5 bits (140), Expect = 1e-08
Identities = 75/366 (20%), Positives = 150/366 (40%), Gaps = 52/366 (14%)
Query: 34 LVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDLVRKSGNSVTLLVLDGDSYE 93
+ +++ + AE L+ D +LR+N V V + H + V+ ++++G+ V L V
Sbjct: 78 ITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVR---RRR 134
Query: 94 KAVKTRVDLKELGQSQKEQGLSDNILSPVMNGGVQTWTQPRLCYLVKEGGSY-------- 145
++T V++K + +GL +I V N + + ++ G +
Sbjct: 135 PILETVVEIKLF---KGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVG 191
Query: 146 -------GFSLKTVQGKKGV--------------------YMTD-ITPQGVAMRAGVLAD 177
+SL+ V ++ V YMTD P + +
Sbjct: 192 DRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPME 251
Query: 178 DHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRETASLKL- 236
+HL+ N +E + + + S L+ D T H + ++ + +L+
Sbjct: 252 NHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTS--HSQHSTATRQPSMTLQRA 309
Query: 237 --LPHQPRIVEMKKGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEAG-LKNNDLVVAVNG 293
L +PR V + KGS G GF + G + +G + I +G PA+ +G L+ D +++VNG
Sbjct: 310 VSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNG 369
Query: 294 ESVETLDHDSVVEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVKEAP 353
+ H+ + KG QT ++ + ++ A F ++ +++ N S+
Sbjct: 370 IDLRGASHEQAAAAL-KGAGQTVTIIAQYQPED---YARFEAKIHDLREQMMNHSMSSGS 425
Query: 354 APTPTS 359
T+
Sbjct: 426 GSLRTN 431
Score = 53.1 bits (126), Expect = 6e-07
Identities = 67/323 (20%), Positives = 121/323 (37%), Gaps = 64/323 (19%)
Query: 26 IEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDLVRKSGNSVTLL 85
I D ++ ++++ + + LQ GDR+L +N +++ H + V +++ + V L
Sbjct: 165 IPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLK 224
Query: 86 V-----------------------------LDGDSYEKAVKTRVDLKELGQ--------- 107
V L G++ KT + G+
Sbjct: 225 VGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHML 284
Query: 108 ------SQKEQGLSDNILSPVMNGGVQTWTQPRLCYLVKEGGSYGFSLKTVQGKKGVYMT 161
S + + S + V +PR L K GF++ + +G++++
Sbjct: 285 VDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVS 344
Query: 162 DITPQGVAMRAGVL-ADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLVDKETDKRH 220
I G A +G L D ++ VNG ++ ASHE+ +K +G V + + D
Sbjct: 345 FILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYAR 404
Query: 221 VEQKIQFKRETASLKLLPHQPRIVEMKKGSNGY------GFYLRAGSEQKGQIIKDIDSG 274
E KI RE +++ H M GS Y+RA + K DSG
Sbjct: 405 FEAKIHDLRE----QMMNH-----SMSSGSGSLRTNQKRSLYVRAMFDYD----KSKDSG 451
Query: 275 SPAEEAGLKNNDLVVAVNGESVE 297
P++ K D++ +N E
Sbjct: 452 LPSQGLSFKYGDILHVINASDDE 474
Score = 42.7 bits (99), Expect = 8e-04
Identities = 29/117 (24%), Positives = 53/117 (45%), Gaps = 7/117 (5%)
Query: 210 LLVDKETDKRHVEQKIQFKRETASLKLLPHQPRIVEMKKGSNGYGFYLRAGSEQKGQ--- 266
LL D + EQ +Q + + ++ + +++G++G GF + G++
Sbjct: 14 LLWDTIASLKQCEQAMQHAFIPVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDD 73
Query: 267 ----IIKDIDSGSPAEEAGLKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLV 319
I K I G+ AE+ L+ ND ++ VN V + H VE +++ G L V
Sbjct: 74 PGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYV 130
Score = 38.5 bits (88), Expect = 0.015
Identities = 25/80 (31%), Positives = 42/80 (52%), Gaps = 2/80 (2%)
Query: 7 PRECKLSKQEGQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAG-LQDGDRVLRINGVFVDK 65
PR+ L K GF + +D EG V + PA+ +G LQ GD++L +NG+ +
Sbjct: 316 PRKVVLHKGS-TGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRG 374
Query: 66 EEHMQVVDLVRKSGNSVTLL 85
H Q ++ +G +VT++
Sbjct: 375 ASHEQAAAALKGAGQTVTII 394
>gi|218505835 membrane-associated guanylate kinase-related 3 isoform
1 [Homo sapiens]
Length = 1481
Score = 87.0 bits (214), Expect = 4e-17
Identities = 129/517 (24%), Positives = 214/517 (41%), Gaps = 87/517 (16%)
Query: 21 GFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDLVRKS-- 78
GF I G V+++ + GLQ GD + I V H+QVV+++++
Sbjct: 587 GFGFAIADSPTGQKVKMILDSQWCQ--GLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPV 644
Query: 79 GNSVTLLVLDGD--SYEKAVKTRVDLKELGQSQKEQGLSDNILSP------VMNGGV--- 127
G V LL+L G S K K + D KE S + +++ I P ++ G
Sbjct: 645 GADVPLLILRGGPPSPTKTAKMKTDKKENAGSL--EAINEPIPQPMPFPPSIIRSGSPKL 702
Query: 128 ---QTWTQPRLCY-------------LVKEGGSYGFSLKTVQGK-KGVYMTDITPQGVAM 170
+ + + + Y L K+ +GF + G + +Y+ I P G A
Sbjct: 703 DPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAE 762
Query: 171 RAGVL-ADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLVDKET----DKRHVEQKI 225
+ G L A D L+ ++G V+ SH++V++ + + LL + +K+ +
Sbjct: 763 KDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSS 822
Query: 226 Q-----------FKRETASLKLLPHQPR-IVEMKKGSNGYGFYLRAGSEQK--GQI---I 268
Q R + P +P +V +K + G+GF + + G I I
Sbjct: 823 QAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKI 882
Query: 269 KDIDSGSPAEEAG-LKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLVVDKE---- 323
+ GSPA+ G LK D + AVNG+S+ L HD++V++I+ G +L V+ +E
Sbjct: 883 GRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHG 942
Query: 324 TDNMYRLAHFSPFLYY------QSQELP---NGSVKEAPAPTPTSLEVS-------SPPD 367
+ A SP L + Q+ +P + E TS S + PD
Sbjct: 943 PPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPD 1002
Query: 368 T----TEEVDHKPKL----CRLAKGENGYGFHLNAIRGL-PGSFIKEVQKGGPADLAG-L 417
T H L L +G G+GF L + G FI + + GPA G +
Sbjct: 1003 TAVISVVGSRHNQNLGCYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRI 1062
Query: 418 EDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTLLV 454
D I+E+NG + + ++ IQ+ G V LL+
Sbjct: 1063 HVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLL 1099
Score = 64.7 bits (156), Expect = 2e-10
Identities = 59/251 (23%), Positives = 108/251 (43%), Gaps = 46/251 (18%)
Query: 7 PRECKLSKQEGQNYGFFLRIEKDTEG-----HLVRVVEKCSPAEKAG-LQDGDRVLRING 60
P + L ++E + +GF + K+ H + V + SPA++ G L+ GD + +NG
Sbjct: 849 PYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNG 908
Query: 61 VFVDKEEHMQVVDLVRKSGNSVTLLVLDGDSY--------EKAVKTRVDLKELGQSQ--- 109
+ + H +V L++ +G +VTL V+ + + + + +GQSQ
Sbjct: 909 QSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANH 968
Query: 110 ---KEQGLSDNILSPVMNGGVQTWT------QPRL---------------CYLVK-EGGS 144
L I V +W+ QP CY V+ E G
Sbjct: 969 IPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGP 1028
Query: 145 YGFSLKTVQGKK---GVYMTDITPQGVAMRAG-VLADDHLIEVNGENVEDASHEEVVEKV 200
GF GK+ G+++ + G A++ G + D ++E+NGE + +H +E +
Sbjct: 1029 RGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELI 1088
Query: 201 KKSGSRVMFLL 211
+ G++V+ LL
Sbjct: 1089 QAGGNKVLLLL 1099
Score = 46.6 bits (109), Expect = 6e-05
Identities = 77/387 (19%), Positives = 148/387 (38%), Gaps = 75/387 (19%)
Query: 131 TQPRLCYLVKEGGSYGFSLKTVQGKKGVYMTDITPQGVAMRAGVLADDHLIEVNGENVED 190
+QP L + G GF G + I G+ D + E+ +NV++
Sbjct: 572 SQPELVTIPLIKGPKGFGFAIADSPTGQKVKMILDSQWCQ--GLQKGDIIKEIYHQNVQN 629
Query: 191 ASHEEVVEKVKKS--GSRVMFLLV--DKETDKRHVEQKIQFKRETASLKLL--------P 238
+H +VVE +K+ G+ V L++ + + + K K SL+ + P
Sbjct: 630 LTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEPIPQPMP 689
Query: 239 HQPRIVE--------------------------------MKKGSNGYGFYLRAGS--EQK 264
P I+ ++K +G+GF + G +Q
Sbjct: 690 FPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGGDGPDQS 749
Query: 265 GQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLVVDKET 324
I I G+ ++ L+ D ++ ++G V+ H V++++ +L+ +
Sbjct: 750 IYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRK 809
Query: 325 DNMYRLAHFSPFLYYQSQELPNGSVK-----EAPAPTPTSLEVSSPPDTTEEVDHKPKLC 379
++Y ++ + S + + +P EV + P E D +
Sbjct: 810 ------------IFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPAPQEPYD----VV 853
Query: 380 RLAKGENGYGFHLNAIRGLPGSF-----IKEVQKGGPADLAG-LEDEDVIIEVNGVNVLD 433
K G+GF + + P I V +G PAD G L+ D I VNG ++++
Sbjct: 854 LQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVE 913
Query: 434 EPYEKVVDRIQSSGKNVTLLVCGKKAY 460
++ +V I+ +G VTL V ++ +
Sbjct: 914 LSHDNIVQLIKDAGVTVTLTVIAEEEH 940
Score = 46.2 bits (108), Expect = 7e-05
Identities = 58/224 (25%), Positives = 100/224 (44%), Gaps = 34/224 (15%)
Query: 12 LSKQEGQNYGFFLRI---EKDTEGHLVRVVEKCSPAEKAG-LQDGDRVLRINGVFVDKEE 67
L KQE GF R+ + + + + AEK G L+ D ++ I+G+ V +
Sbjct: 729 LRKQES---GFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKS 785
Query: 68 HMQVVDLVRKSGNSVTLLVLDGDSYEKAVKTRVDLKELGQSQKEQGLSDNIL-----SPV 122
H QV+DL+ + + +L+ V+ ++ G+ Q E S + SP
Sbjct: 786 HKQVLDLMTTAARNGHVLL--------TVRRKI---FYGEKQPEDDSSQAFISTQNGSPR 834
Query: 123 MN-GGVQTWTQPRLCYLV----KEGGSYGFSLKTVQGK--KGVY---MTDITPQGVAMRA 172
+N V P+ Y V KE +GF + T + K GV + + A R
Sbjct: 835 LNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRC 894
Query: 173 GVL-ADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLVDKE 215
G L DH+ VNG+++ + SH+ +V+ +K +G V ++ +E
Sbjct: 895 GKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEE 938
Score = 43.1 bits (100), Expect = 6e-04
Identities = 57/250 (22%), Positives = 108/250 (43%), Gaps = 37/250 (14%)
Query: 240 QPRIVEMK--KGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVE 297
QP +V + KG G+GF + GQ +K I + GL+ D++ + ++V+
Sbjct: 573 QPELVTIPLIKGPKGFGFAI--ADSPTGQKVKMILDSQWCQ--GLQKGDIIKEIYHQNVQ 628
Query: 298 TLDHDSVVEMIR-------------KGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQEL 344
L H VVE+++ +GG + +TD Q +
Sbjct: 629 NLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEPIPQPM 688
Query: 345 P-------NGSVKEAPAPT---PTSLEVSSPPDTTEEVDHKPKLCRLAKGENGYGFHLNA 394
P +GS K P+ +L PP+ T+++D L K E+G+GF +
Sbjct: 689 PFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPN-TKDLD-----VFLRKQESGFGFRVLG 742
Query: 395 IRGLPGS-FIKEVQKGGPADLAG-LEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTL 452
G S +I + G A+ G L D ++ ++G+ V + +++V+D + ++ +N +
Sbjct: 743 GDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHV 802
Query: 453 LVCGKKAYDY 462
L+ ++ Y
Sbjct: 803 LLTVRRKIFY 812
Score = 40.8 bits (94), Expect = 0.003
Identities = 86/377 (22%), Positives = 148/377 (39%), Gaps = 85/377 (22%)
Query: 124 NGGVQTWTQPRLCYLVK-----EGGSYGFSLKTVQGKK-GVYMTDITPQGVAMRAGVLAD 177
N TW PRLC K E G + + ++ + G Y D Q
Sbjct: 315 NTKTTTWLDPRLCKKAKAPEDCEDGELPYGWEKIEDPQYGTYYVDHLNQ----------- 363
Query: 178 DHLIEVNGEN-VEDASHEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRETASLKL 236
+ EN VE+A ++ + +V+ S+ + +K H F R+ + LK
Sbjct: 364 ----KTQFENPVEEAKRKKQLGQVEIGSSK-------PDMEKSH------FTRDPSQLKG 406
Query: 237 LPHQPRIVEMKKGSNGYGFYLRAGSE-----QKGQIIKDIDSGSPAEEAGLKNNDLVVAV 291
+ + +KK + G+GF + G Q ++KD G A++ + D++V +
Sbjct: 407 VLVR---ASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKD---GPAAQDGKIAPGDVIVDI 460
Query: 292 NGESVETLDHDSVVEMIR--KGGDQTSLLVV------DKETDNMYRLAHFSPFLYYQS-- 341
NG V H VV+M + +L + D D + + +P + QS
Sbjct: 461 NGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLT 520
Query: 342 --------QELPNGSV----KEAPAPTPTSLEVSSPPDTTEE-------VDHKPKLCR-- 380
Q+ G++ T T ++ P D +E+ +P+L
Sbjct: 521 KGETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIP 580
Query: 381 LAKGENGYGFHLNAIRGLP-GSFIKEVQKGGPADLAGLEDEDVIIEVNGVNVLDEPYEKV 439
L KG G+GF AI P G +K + GL+ D+I E+ NV + + +V
Sbjct: 581 LIKGPKGFGF---AIADSPTGQKVKMILDSQWCQ--GLQKGDIIKEIYHQNVQNLTHLQV 635
Query: 440 VDRIQS--SGKNVTLLV 454
V+ ++ G +V LL+
Sbjct: 636 VEVLKQFPVGADVPLLI 652
Score = 35.8 bits (81), Expect = 0.097
Identities = 23/74 (31%), Positives = 39/74 (52%), Gaps = 2/74 (2%)
Query: 18 QNYGFFLRIEKDTE-GHLVRVVEKCSPAEKAG-LQDGDRVLRINGVFVDKEEHMQVVDLV 75
+ +GF LR K+ G + + + PA K G + GD+++ ING H + ++L+
Sbjct: 1029 RGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELI 1088
Query: 76 RKSGNSVTLLVLDG 89
+ GN V LL+ G
Sbjct: 1089 QAGGNKVLLLLRPG 1102
Score = 34.3 bits (77), Expect = 0.28
Identities = 39/125 (31%), Positives = 54/125 (43%), Gaps = 14/125 (11%)
Query: 363 SSPPD------TTEEVDHKPKLCRLAKGENGYGFHLNAIRG-LPGSF--IKEVQKGGPAD 413
SS PD T + K L R + ++ GF I G P F +K V K GPA
Sbjct: 387 SSKPDMEKSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAA 446
Query: 414 LAG-LEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKN--VTLLVCGKKAYDYFQAKKIPI 470
G + DVI+++NG VL + VV Q N V L +C + Y + P+
Sbjct: 447 QDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLC--RGYPLPDDSEDPV 504
Query: 471 VSSLA 475
V +A
Sbjct: 505 VDIVA 509
>gi|155969695 membrane-associated guanylate kinase-related 3 isoform
2 [Homo sapiens]
Length = 1125
Score = 87.0 bits (214), Expect = 4e-17
Identities = 129/517 (24%), Positives = 214/517 (41%), Gaps = 87/517 (16%)
Query: 21 GFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDLVRKS-- 78
GF I G V+++ + GLQ GD + I V H+QVV+++++
Sbjct: 587 GFGFAIADSPTGQKVKMILDSQWCQ--GLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPV 644
Query: 79 GNSVTLLVLDGD--SYEKAVKTRVDLKELGQSQKEQGLSDNILSP------VMNGGV--- 127
G V LL+L G S K K + D KE S + +++ I P ++ G
Sbjct: 645 GADVPLLILRGGPPSPTKTAKMKTDKKENAGSL--EAINEPIPQPMPFPPSIIRSGSPKL 702
Query: 128 ---QTWTQPRLCY-------------LVKEGGSYGFSLKTVQGK-KGVYMTDITPQGVAM 170
+ + + + Y L K+ +GF + G + +Y+ I P G A
Sbjct: 703 DPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAE 762
Query: 171 RAGVL-ADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLVDKET----DKRHVEQKI 225
+ G L A D L+ ++G V+ SH++V++ + + LL + +K+ +
Sbjct: 763 KDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSS 822
Query: 226 Q-----------FKRETASLKLLPHQPR-IVEMKKGSNGYGFYLRAGSEQK--GQI---I 268
Q R + P +P +V +K + G+GF + + G I I
Sbjct: 823 QAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKI 882
Query: 269 KDIDSGSPAEEAG-LKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLVVDKE---- 323
+ GSPA+ G LK D + AVNG+S+ L HD++V++I+ G +L V+ +E
Sbjct: 883 GRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHG 942
Query: 324 TDNMYRLAHFSPFLYY------QSQELP---NGSVKEAPAPTPTSLEVS-------SPPD 367
+ A SP L + Q+ +P + E TS S + PD
Sbjct: 943 PPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPD 1002
Query: 368 T----TEEVDHKPKL----CRLAKGENGYGFHLNAIRGL-PGSFIKEVQKGGPADLAG-L 417
T H L L +G G+GF L + G FI + + GPA G +
Sbjct: 1003 TAVISVVGSRHNQNLGCYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRI 1062
Query: 418 EDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTLLV 454
D I+E+NG + + ++ IQ+ G V LL+
Sbjct: 1063 HVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLL 1099
Score = 64.7 bits (156), Expect = 2e-10
Identities = 59/251 (23%), Positives = 108/251 (43%), Gaps = 46/251 (18%)
Query: 7 PRECKLSKQEGQNYGFFLRIEKDTEG-----HLVRVVEKCSPAEKAG-LQDGDRVLRING 60
P + L ++E + +GF + K+ H + V + SPA++ G L+ GD + +NG
Sbjct: 849 PYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNG 908
Query: 61 VFVDKEEHMQVVDLVRKSGNSVTLLVLDGDSY--------EKAVKTRVDLKELGQSQ--- 109
+ + H +V L++ +G +VTL V+ + + + + +GQSQ
Sbjct: 909 QSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANH 968
Query: 110 ---KEQGLSDNILSPVMNGGVQTWT------QPRL---------------CYLVK-EGGS 144
L I V +W+ QP CY V+ E G
Sbjct: 969 IPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGP 1028
Query: 145 YGFSLKTVQGKK---GVYMTDITPQGVAMRAG-VLADDHLIEVNGENVEDASHEEVVEKV 200
GF GK+ G+++ + G A++ G + D ++E+NGE + +H +E +
Sbjct: 1029 RGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELI 1088
Query: 201 KKSGSRVMFLL 211
+ G++V+ LL
Sbjct: 1089 QAGGNKVLLLL 1099
Score = 46.6 bits (109), Expect = 6e-05
Identities = 77/387 (19%), Positives = 148/387 (38%), Gaps = 75/387 (19%)
Query: 131 TQPRLCYLVKEGGSYGFSLKTVQGKKGVYMTDITPQGVAMRAGVLADDHLIEVNGENVED 190
+QP L + G GF G + I G+ D + E+ +NV++
Sbjct: 572 SQPELVTIPLIKGPKGFGFAIADSPTGQKVKMILDSQWCQ--GLQKGDIIKEIYHQNVQN 629
Query: 191 ASHEEVVEKVKKS--GSRVMFLLV--DKETDKRHVEQKIQFKRETASLKLL--------P 238
+H +VVE +K+ G+ V L++ + + + K K SL+ + P
Sbjct: 630 LTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEPIPQPMP 689
Query: 239 HQPRIVE--------------------------------MKKGSNGYGFYLRAGS--EQK 264
P I+ ++K +G+GF + G +Q
Sbjct: 690 FPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGGDGPDQS 749
Query: 265 GQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLVVDKET 324
I I G+ ++ L+ D ++ ++G V+ H V++++ +L+ +
Sbjct: 750 IYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRK 809
Query: 325 DNMYRLAHFSPFLYYQSQELPNGSVK-----EAPAPTPTSLEVSSPPDTTEEVDHKPKLC 379
++Y ++ + S + + +P EV + P E D +
Sbjct: 810 ------------IFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPAPQEPYD----VV 853
Query: 380 RLAKGENGYGFHLNAIRGLPGSF-----IKEVQKGGPADLAG-LEDEDVIIEVNGVNVLD 433
K G+GF + + P I V +G PAD G L+ D I VNG ++++
Sbjct: 854 LQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVE 913
Query: 434 EPYEKVVDRIQSSGKNVTLLVCGKKAY 460
++ +V I+ +G VTL V ++ +
Sbjct: 914 LSHDNIVQLIKDAGVTVTLTVIAEEEH 940
Score = 46.2 bits (108), Expect = 7e-05
Identities = 58/224 (25%), Positives = 100/224 (44%), Gaps = 34/224 (15%)
Query: 12 LSKQEGQNYGFFLRI---EKDTEGHLVRVVEKCSPAEKAG-LQDGDRVLRINGVFVDKEE 67
L KQE GF R+ + + + + AEK G L+ D ++ I+G+ V +
Sbjct: 729 LRKQES---GFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKS 785
Query: 68 HMQVVDLVRKSGNSVTLLVLDGDSYEKAVKTRVDLKELGQSQKEQGLSDNIL-----SPV 122
H QV+DL+ + + +L+ V+ ++ G+ Q E S + SP
Sbjct: 786 HKQVLDLMTTAARNGHVLL--------TVRRKI---FYGEKQPEDDSSQAFISTQNGSPR 834
Query: 123 MN-GGVQTWTQPRLCYLV----KEGGSYGFSLKTVQGK--KGVY---MTDITPQGVAMRA 172
+N V P+ Y V KE +GF + T + K GV + + A R
Sbjct: 835 LNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRC 894
Query: 173 GVL-ADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLVDKE 215
G L DH+ VNG+++ + SH+ +V+ +K +G V ++ +E
Sbjct: 895 GKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEE 938
Score = 43.1 bits (100), Expect = 6e-04
Identities = 57/250 (22%), Positives = 108/250 (43%), Gaps = 37/250 (14%)
Query: 240 QPRIVEMK--KGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVE 297
QP +V + KG G+GF + GQ +K I + GL+ D++ + ++V+
Sbjct: 573 QPELVTIPLIKGPKGFGFAI--ADSPTGQKVKMILDSQWCQ--GLQKGDIIKEIYHQNVQ 628
Query: 298 TLDHDSVVEMIR-------------KGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQEL 344
L H VVE+++ +GG + +TD Q +
Sbjct: 629 NLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEPIPQPM 688
Query: 345 P-------NGSVKEAPAPT---PTSLEVSSPPDTTEEVDHKPKLCRLAKGENGYGFHLNA 394
P +GS K P+ +L PP+ T+++D L K E+G+GF +
Sbjct: 689 PFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPN-TKDLD-----VFLRKQESGFGFRVLG 742
Query: 395 IRGLPGS-FIKEVQKGGPADLAG-LEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTL 452
G S +I + G A+ G L D ++ ++G+ V + +++V+D + ++ +N +
Sbjct: 743 GDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHV 802
Query: 453 LVCGKKAYDY 462
L+ ++ Y
Sbjct: 803 LLTVRRKIFY 812
Score = 40.8 bits (94), Expect = 0.003
Identities = 86/377 (22%), Positives = 148/377 (39%), Gaps = 85/377 (22%)
Query: 124 NGGVQTWTQPRLCYLVK-----EGGSYGFSLKTVQGKK-GVYMTDITPQGVAMRAGVLAD 177
N TW PRLC K E G + + ++ + G Y D Q
Sbjct: 315 NTKTTTWLDPRLCKKAKAPEDCEDGELPYGWEKIEDPQYGTYYVDHLNQ----------- 363
Query: 178 DHLIEVNGEN-VEDASHEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRETASLKL 236
+ EN VE+A ++ + +V+ S+ + +K H F R+ + LK
Sbjct: 364 ----KTQFENPVEEAKRKKQLGQVEIGSSK-------PDMEKSH------FTRDPSQLKG 406
Query: 237 LPHQPRIVEMKKGSNGYGFYLRAGSE-----QKGQIIKDIDSGSPAEEAGLKNNDLVVAV 291
+ + +KK + G+GF + G Q ++KD G A++ + D++V +
Sbjct: 407 VLVR---ASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKD---GPAAQDGKIAPGDVIVDI 460
Query: 292 NGESVETLDHDSVVEMIR--KGGDQTSLLVV------DKETDNMYRLAHFSPFLYYQS-- 341
NG V H VV+M + +L + D D + + +P + QS
Sbjct: 461 NGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLT 520
Query: 342 --------QELPNGSV----KEAPAPTPTSLEVSSPPDTTEE-------VDHKPKLCR-- 380
Q+ G++ T T ++ P D +E+ +P+L
Sbjct: 521 KGETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIP 580
Query: 381 LAKGENGYGFHLNAIRGLP-GSFIKEVQKGGPADLAGLEDEDVIIEVNGVNVLDEPYEKV 439
L KG G+GF AI P G +K + GL+ D+I E+ NV + + +V
Sbjct: 581 LIKGPKGFGF---AIADSPTGQKVKMILDSQWCQ--GLQKGDIIKEIYHQNVQNLTHLQV 635
Query: 440 VDRIQS--SGKNVTLLV 454
V+ ++ G +V LL+
Sbjct: 636 VEVLKQFPVGADVPLLI 652
Score = 35.8 bits (81), Expect = 0.097
Identities = 23/74 (31%), Positives = 39/74 (52%), Gaps = 2/74 (2%)
Query: 18 QNYGFFLRIEKDTE-GHLVRVVEKCSPAEKAG-LQDGDRVLRINGVFVDKEEHMQVVDLV 75
+ +GF LR K+ G + + + PA K G + GD+++ ING H + ++L+
Sbjct: 1029 RGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELI 1088
Query: 76 RKSGNSVTLLVLDG 89
+ GN V LL+ G
Sbjct: 1089 QAGGNKVLLLLRPG 1102
Score = 34.3 bits (77), Expect = 0.28
Identities = 39/125 (31%), Positives = 54/125 (43%), Gaps = 14/125 (11%)
Query: 363 SSPPD------TTEEVDHKPKLCRLAKGENGYGFHLNAIRG-LPGSF--IKEVQKGGPAD 413
SS PD T + K L R + ++ GF I G P F +K V K GPA
Sbjct: 387 SSKPDMEKSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAA 446
Query: 414 LAG-LEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKN--VTLLVCGKKAYDYFQAKKIPI 470
G + DVI+++NG VL + VV Q N V L +C + Y + P+
Sbjct: 447 QDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLC--RGYPLPDDSEDPV 504
Query: 471 VSSLA 475
V +A
Sbjct: 505 VDIVA 509
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 83.6 bits (205), Expect = 4e-16
Identities = 109/492 (22%), Positives = 211/492 (42%), Gaps = 75/492 (15%)
Query: 24 LRIEKDTE-GHLVRVVEKCSPAEKAG-LQDGDRVLRINGVFVDKE-EHMQVVDLVRKSGN 80
LR E E G V+ +++ S A + G L++ D++L ING +D+ H Q + +++K+ +
Sbjct: 155 LRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAISILQKAKD 214
Query: 81 SVTLLVLDGDSYEKAVKTRVDLKELGQSQKEQGLSDNILSPVMNGGVQTWTQPRLCYLVK 140
+V L++ G S + V V +S +PV W LV
Sbjct: 215 TVQLVIARG-SLPQLVSPIVS-----RSPSAASTISAHSNPVH------WQHMETIELVN 262
Query: 141 EGGSYGFSLKTVQGKK-GVYMTDITPQGVAMRAGVLAD-DHLIEVNGENVEDASHEEVVE 198
+G GF + + GK GV + I P GVA + G L DH++++ ++ S E+V +
Sbjct: 263 DGSGLGFGI--IGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQ 320
Query: 199 KVKKSGSRVMFLLVDKETDKRHVEQKI------------QFKRETASLKLLPHQPRIVEM 246
+++ G+RV ++ ++R + + + + ++ K + VE+
Sbjct: 321 VLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEESETFDVEL 380
Query: 247 KKGSNGYGFYLRA-----GSEQKGQIIKDIDSGSPAEEAG-LKNNDLVVAVNGESVETLD 300
K G G + E G +K I S E G ++ D ++AV+G +++
Sbjct: 381 TKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFT 440
Query: 301 HDSVVEMIRKGGDQTSLLVVDK----------ETDNMYRLAHFSPF-------LYYQSQE 343
+ VE++R G QT LL + + +++ + A SP Y + ++
Sbjct: 441 NQQAVEVLRHTG-QTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKENYEKDED 499
Query: 344 LPNGSVKEAPAPTP------TSLEVSSPPDTTEE-------------VDHKPKLCRLAKG 384
+ + PT S E+ D ++ ++++ + ++K
Sbjct: 500 FLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKF 559
Query: 385 ENGYGFHLNAIRGLPGSFIKEVQKGGPADLAG-LEDEDVIIEVNGVNVLDEPYEKVVDRI 443
G ++ + FI+ V GP +G L D ++EVNG+ +L E ++ VV+ +
Sbjct: 560 SENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNIL 619
Query: 444 QSSGKNVTLLVC 455
+ VT++ C
Sbjct: 620 KELPIEVTMVCC 631
Score = 73.9 bits (180), Expect = 3e-13
Identities = 99/437 (22%), Positives = 178/437 (40%), Gaps = 75/437 (17%)
Query: 37 VVEKCSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDLVRKSGNSVTLLVLDGDSYEKAV 96
V E+ + + L GD++L +NG+ + K H + ++++R++ V L + ++
Sbjct: 1659 VYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEA----- 1713
Query: 97 KTRVDLKELGQSQKEQGLSDNILSPVMNGGVQTWTQPRLCYLVKEGGSYGFSLKTVQGKK 156
KE+ + D + + K G G S+ +
Sbjct: 1714 -----------PYKEEEVCDTLTIELQK---------------KPGKGLGLSIVGKRNDT 1747
Query: 157 GVYMTDITPQGVAMRAG-VLADDHLIEVNGENVEDASHEEVVEKVKKS-GSRVMFLL-VD 213
GV+++DI G+A G ++ D ++ VNGE+V +A+ E V +K S GS F +
Sbjct: 1748 GVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSLSSFTFPLS 1807
Query: 214 KETDKRHVEQKIQFKRETASLKLLPHQPRIVEMKKG-SNGYGFYLRAGSEQKGQIIKDID 272
+ +E + + ++ L R VEMKKG ++ G + G G + D+
Sbjct: 1808 GSSTSESLESSSKKNALASEIQGL----RTVEMKKGPTDSLGISIAGGV---GSPLGDVP 1860
Query: 273 --------SGSPAEEAGLKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLVVDKET 324
+G A+ L+ D +V + G S E + H V +++ + VV
Sbjct: 1861 IFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVV---- 1916
Query: 325 DNMYRLAHFSPFLYYQSQELPNGSVKEAPAPTPTSL--EVSSPPDTTEEVDHKPKLCRLA 382
A + Q+ P S T +S+ + PP K L
Sbjct: 1917 ------AGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQC--------KSITLE 1962
Query: 383 KGENGYGFHLNAIRGLPGS----FIKEV-QKGGPADLAGLEDEDVIIEVNGVNVLDEPYE 437
+G +G GF + G P ++K V KG ++ L+ D II VNG ++ +E
Sbjct: 1963 RGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHE 2022
Query: 438 KVVDRIQSSGKNVTLLV 454
+ V ++ + VTL+V
Sbjct: 2023 EAVAILKRTKGTVTLMV 2039
Score = 66.6 bits (161), Expect = 5e-11
Identities = 75/330 (22%), Positives = 147/330 (44%), Gaps = 36/330 (10%)
Query: 11 KLSKQEGQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAG-LQDGDRVLRINGVFVDKEEHM 69
+L K+ G+ G + +++ G V + K A+ G L GD++L +NG V
Sbjct: 1727 ELQKKPGKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQE 1786
Query: 70 QVVDLVRKSGNSVTLLV--LDGDSYEKAVKTRVDLKELGQSQKEQGLSDNILSPVMNGGV 127
V L++ S S++ L G S +++++ K+ + + QGL V
Sbjct: 1787 AVAALLKVSEGSLSSFTFPLSGSSTSESLES--SSKKNALASEIQGLRT----------V 1834
Query: 128 QTWTQPRLCYLVKEGGSYGFSLKTVQGKKGVYMTDITPQGVAMRAGVL-ADDHLIEVNGE 186
+ P + G G L G +++ + P GVA + L D ++ + G
Sbjct: 1835 EMKKGPTDSLGISIAGGVGSPL----GDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGT 1890
Query: 187 NVEDASHEEVVEKVKKSGSRVMFLLV---DKETDKRHVEQ----KIQFKRETASL----K 235
+ E +H + V +K + + +V D H ++ + F T+S
Sbjct: 1891 STEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDD 1950
Query: 236 LLPHQPRIVEMKKGSNGYGFYLRAG-SEQKGQI---IKDIDS-GSPAEEAGLKNNDLVVA 290
L P Q + + +++G +G GF + G G + +K + + G+ +E+ LK D ++A
Sbjct: 1951 LGPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIA 2010
Query: 291 VNGESVETLDHDSVVEMIRKGGDQTSLLVV 320
VNG+S+E + H+ V ++++ +L+V+
Sbjct: 2011 VNGQSLEGVTHEEAVAILKRTKGTVTLMVL 2040
Score = 55.8 bits (133), Expect = 9e-08
Identities = 71/343 (20%), Positives = 136/343 (39%), Gaps = 49/343 (14%)
Query: 153 QGKKGVYMTDITPQGVAMRAGVLA-DDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLL 211
+ + V++ I P G A + G L D L+E+NG+ + SH+ +K + S+V +
Sbjct: 1370 RSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIF 1429
Query: 212 VDKETDKRHV--------------EQKIQFKR------------ETASLKLLPHQPRIVE 245
+ + + + +Q K + +S K + H +E
Sbjct: 1430 IRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVDLSSFKNVQH----LE 1485
Query: 246 MKKGSNGYGFYLRAGSEQKGQIIKDI-DSGSPAEEAGLKNNDLVVAVNGESVETLDHDSV 304
+ K G G + G IIK + + G A + LK D ++AV+ E V +
Sbjct: 1486 LPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKF 1545
Query: 305 VEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVKEAPAPTPTSLEVSS 364
+ +++ L + + D+ + + + V ++ +P P S+ +S
Sbjct: 1546 ISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTS 1605
Query: 365 PPDTTEEVDHKPKLC----------RLAKGENGYGFHLNAIRG----LPGSFIKEVQKGG 410
T P C ++KG G G L+ + G L I EV + G
Sbjct: 1606 RSSTPAIFASDPATCPIIPGCETTIEISKGRTGLG--LSIVGGSDTLLGAIIIHEVYEEG 1663
Query: 411 PADLAG-LEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTL 452
A G L D I+EVNG+++ +++ ++ ++ + + V L
Sbjct: 1664 AACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRL 1706
Score = 55.5 bits (132), Expect = 1e-07
Identities = 43/159 (27%), Positives = 77/159 (48%), Gaps = 25/159 (15%)
Query: 67 EHMQV--VDLVRKSGNSVTLLVLDGDSYEKAVKTRVDLKELGQSQKEQGLSDNILSPVMN 124
EH++ + L ++SG + L + SY T D+ EL + ++ +G S + N
Sbjct: 1092 EHLEEFKISLGQQSGRVMALDIFS--SY-----TGRDIPELPEREEGEGEE----SELQN 1140
Query: 125 GGVQTWTQPRLCYLVKE-----------GGSYGFSLKTVQGKKGVYMTDITPQGVAMRAG 173
W QPR L +E G G L + +G+++ + A + G
Sbjct: 1141 TAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNG 1200
Query: 174 VLAD-DHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLL 211
L D ++EV+G ++ DASHE+ VE ++K+G+ V+F++
Sbjct: 1201 TLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMV 1239
Score = 55.1 bits (131), Expect = 2e-07
Identities = 62/229 (27%), Positives = 97/229 (42%), Gaps = 36/229 (15%)
Query: 18 QNYGFFLRIEKDTEGHLVRVVEKCSPAEKAG-LQDGDRVLRINGVFVDKEEHMQVVDLVR 76
+N G + +E H +R V P +G L GD +L +NG+ + E H VV++++
Sbjct: 561 ENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILK 620
Query: 77 KSGNSVTLLV---------------LDGDSYEKAVKTRVDLKE-LGQSQKEQGLSDNILS 120
+ VT++ LD E K VDL E +G S+ E D +L+
Sbjct: 621 ELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSETE----DPVLA 676
Query: 121 PVMNGGVQTWTQPRLCY---------LVKEGGSYGFSLKTVQ-----GKKGVYMTDITPQ 166
G Q L L K GFS+ Q + + + P
Sbjct: 677 MTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPG 736
Query: 167 GVAMRAG-VLADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLVDK 214
G+A + G +L D L+ VN N+E++S EE VE +K + S + + V K
Sbjct: 737 GIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAK 785
Score = 54.3 bits (129), Expect = 3e-07
Identities = 89/446 (19%), Positives = 161/446 (36%), Gaps = 90/446 (20%)
Query: 49 LQDGDRVLRINGVFVDKEEHMQVVDLVRKSGNSVTLLVL-DGDSYEKAVKTRVDLKELGQ 107
LQ D +L ING + H +++ + + V ++ + + D+ + + E
Sbjct: 1392 LQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLP 1451
Query: 108 SQKEQGLSDNILSPVMNGG-----VQTWTQPRLCYLVKEGGSYGFSLKTVQGKKGVYMTD 162
S E L + P + + ++ + L K+ G G ++ GV +
Sbjct: 1452 SNSEN-LQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKS 1510
Query: 163 ITPQGVAMRAGVL-ADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLVDKETD---- 217
+T GVA G L D ++ V+ E V E+ + +K + V + + D
Sbjct: 1511 LTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAV 1570
Query: 218 ----------KRHVEQKIQ-----------------------FKRETASLKLLPHQPRIV 244
K++ Q + F + A+ ++P +
Sbjct: 1571 PSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTI 1630
Query: 245 EMKKGSNGYGFYLRAGSEQK-GQII--KDIDSGSPAEEAGLKNNDLVVAVNGESVETLDH 301
E+ KG G G + GS+ G II + + G+ ++ L D ++ VNG + H
Sbjct: 1631 EISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATH 1690
Query: 302 DSVVEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVKEAPAPTPTSLE 361
D + ++R +T RL + Y+ +E+ +
Sbjct: 1691 DEAINVLR-------------QTPQRVRLTLYRDEAPYKEEEVCD--------------- 1722
Query: 362 VSSPPDTTEEVDHKPKLCRLAKGENGYGFHLNAIRGLPGSFIKEVQKGGPADLAG-LEDE 420
T E+ KP G G + R G F+ ++ KGG AD G L
Sbjct: 1723 -----TLTIELQKKP--------GKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQG 1769
Query: 421 DVIIEVNGVNVLDEPYEKVVDRIQSS 446
D I+ VNG +V + E V ++ S
Sbjct: 1770 DQILMVNGEDVRNATQEAVAALLKVS 1795
Score = 53.9 bits (128), Expect = 3e-07
Identities = 70/339 (20%), Positives = 135/339 (39%), Gaps = 50/339 (14%)
Query: 1 MTSTFNPRECKLSKQEGQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAG-LQDGDRVLRIN 59
++S N + +L K +G G + E G +++ + + A G L+ GD++L ++
Sbjct: 1475 LSSFKNVQHLELPKDQG-GLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVD 1533
Query: 60 GVFVDKEEHMQVVDLVRKSGNSVTLLVLDGDSYEKAVKTRVDLKELGQSQKEQGLSDNIL 119
V + + L++ + +V L + + +AV + G + E+ S L
Sbjct: 1534 DEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAA-----GAASGEKKNSSQSL 1588
Query: 120 SPVMNGGVQTWT---------------QPRLCYLVK--------EGGSYGFSLKTVQGKK 156
+G + + P C ++ G G L V G
Sbjct: 1589 MVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSD 1648
Query: 157 ----GVYMTDITPQGVAMRAGVL-ADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLL 211
+ + ++ +G A + G L A D ++EVNG ++ A+H+E + ++++ RV L
Sbjct: 1649 TLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTL 1708
Query: 212 VDKETDKRHVEQKIQFKRETASLKLLPHQPRIVEMKKGSNGYGFYLRAGSEQKGQIIKDI 271
E + E +T +++L KK G G + G + DI
Sbjct: 1709 YRDEAPYKEEE-----VCDTLTIEL---------QKKPGKGLGLSIVGKRNDTGVFVSDI 1754
Query: 272 DSGSPAEEAG-LKNNDLVVAVNGESVETLDHDSVVEMIR 309
G A+ G L D ++ VNGE V ++V +++
Sbjct: 1755 VKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLK 1793
Score = 53.1 bits (126), Expect = 6e-07
Identities = 69/287 (24%), Positives = 107/287 (37%), Gaps = 67/287 (23%)
Query: 239 HQPRIVEMKK-----------GSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEAG-LKNND 286
+QPR VE+ + G G G L G +G IK + SPA + G LK D
Sbjct: 1147 NQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGD 1206
Query: 287 LVVAVNGESVETLDHDSVVEMIRKGGDQTSLLV-----------VDKETDNMYRLAHFS- 334
+V V+G + H+ VE IRK G+ +V + N+Y +FS
Sbjct: 1207 RIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSS 1266
Query: 335 --PF---LYYQSQELPNGSVKE--------APAPTPTSL-------------EVSSPPDT 368
PF L + + P+ S E P P P++ ++S D
Sbjct: 1267 TNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDK 1326
Query: 369 TEEVDHKPK--------------LCRLAKGENGYGFHL--NAIRGLPGSFIKEVQKGGPA 412
+E + K + L KG +G G L N R FI + G A
Sbjct: 1327 EDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAA 1386
Query: 413 DLAG-LEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTLLVCGKK 458
G L+ D ++E+NG + ++ I+ + V ++ K
Sbjct: 1387 GKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNK 1433
Score = 43.1 bits (100), Expect = 6e-04
Identities = 46/204 (22%), Positives = 87/204 (42%), Gaps = 13/204 (6%)
Query: 16 EGQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAG-LQDGDRVLRINGVFVDKEEHMQVVDL 74
+G GF + K T G +V+ + A++ G L GD +L+I + QV +
Sbjct: 263 DGSGLGFGIIGGKAT-GVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQV 321
Query: 75 VRKSGNSVTLLVLDGDSYEKAVKTRVDLKELGQSQKEQGLSDNILSPVMNGGVQTWTQPR 134
+R+ GN V L++ G E+ T + + S + + G ++ T
Sbjct: 322 LRQCGNRVKLMIARGAIEERTAPTALGIT---LSSSPTSTPELRVDASTQKGEESETFD- 377
Query: 135 LCYLVKEGGSYGFSLKTVQGKK-----GVYMTDITPQGVAMRAG-VLADDHLIEVNGENV 188
L K G ++ G K G+++ IT G + D +I V+G N+
Sbjct: 378 -VELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNL 436
Query: 189 EDASHEEVVEKVKKSGSRVMFLLV 212
+ ++++ VE ++ +G V+ L+
Sbjct: 437 QGFTNQQAVEVLRHTGQTVLLTLM 460
Score = 42.0 bits (97), Expect = 0.001
Identities = 24/71 (33%), Positives = 40/71 (56%), Gaps = 1/71 (1%)
Query: 17 GQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAG-LQDGDRVLRINGVFVDKEEHMQVVDLV 75
G+ G L + G ++ V + SPA K G L+ GDR++ ++G+ + H Q V+ +
Sbjct: 1169 GRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAI 1228
Query: 76 RKSGNSVTLLV 86
RK+GN V +V
Sbjct: 1229 RKAGNPVVFMV 1239
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 80.9 bits (198), Expect = 3e-15
Identities = 100/436 (22%), Positives = 186/436 (42%), Gaps = 56/436 (12%)
Query: 34 LVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDLVRKSGNSVTLLVLDGDSYE 93
+ +++ + AE L+ D +LR+N V V + H + V+ ++++G+ V L V
Sbjct: 234 ITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVR---RRR 290
Query: 94 KAVKTRVDLKELGQSQKEQGLSDNILSPVMNGGVQTWTQPRLCYLVKEGGSYGFSLKTVQ 153
++T V++K L + K G S + GGV + +
Sbjct: 291 PILETVVEIK-LFKGPKGLGFS-------IAGGVGN--------------------QHIP 322
Query: 154 GKKGVYMTDITPQGVAMRAGVL-ADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLV 212
G +Y+T I G A + G L D L+ VN ++E+ +HEE V + K+ S V++L V
Sbjct: 323 GDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVA-ILKNTSEVVYLKV 381
Query: 213 DKETDKRHVEQKIQFKRETASLKLLPHQPRIVEMKKGSNGYGFYLRAGSEQKGQIIKDID 272
K T + P+ P + S +L +G+ + +
Sbjct: 382 GKPTTIYMTD---------------PYGPPDITHSY-SPPMENHLLSGNNGTLEYKTSLP 425
Query: 273 SGSPAEEAGLKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLVVDKETDNMYRLAH 332
SP + + + LV E + + +V ++ K V E D + L+
Sbjct: 426 PISPGRYSPIPKHMLVDDDYTRPPEPV-YSTVNKLCDKPASPRHYSPV--ECDKSFLLS- 481
Query: 333 FSPFLYYQSQELPNGSVKEAPAPTPTSLEVSSPPDTTEEVDHKPKLCRLAKGENGYGFHL 392
+P+ +Y LP+ + + + + S ++ +P+ L KG G GF++
Sbjct: 482 -APYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNI 540
Query: 393 NAIRGLPGSFIKEVQKGGPADLAG-LEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNVT 451
G F+ + GGPADL+G L+ D I+ VNG+++ +E+ ++ +G+ VT
Sbjct: 541 VGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVT 600
Query: 452 LLV-CGKKAYDYFQAK 466
++ + Y F+AK
Sbjct: 601 IIAQYQPEDYARFEAK 616
Score = 56.2 bits (134), Expect = 7e-08
Identities = 43/171 (25%), Positives = 76/171 (44%), Gaps = 28/171 (16%)
Query: 157 GVYMTDITPQGVAMRAGVL-ADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLVDKE 215
G+++T I P G A G L +D ++ VN +V + SH + VE +K++GS V
Sbjct: 231 GIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIV-------- 282
Query: 216 TDKRHVEQKIQFKRETASLKLLPHQPRIVEMKKGSNGYGFYLRAG-------SEQKGQII 268
+ +V ++ +KL KG G GF + G + +
Sbjct: 283 --RLYVRRRRPILETVVEIKLF----------KGPKGLGFSIAGGVGNQHIPGDNSIYVT 330
Query: 269 KDIDSGSPAEEAGLKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLV 319
K ID G+ ++ L+ D ++ VN S+E + H+ V +++ + L V
Sbjct: 331 KIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 381
Score = 50.1 bits (118), Expect = 5e-06
Identities = 45/173 (26%), Positives = 74/173 (42%), Gaps = 20/173 (11%)
Query: 132 QPRLCYLVKEGGSYGFSLKTVQGKKGVYMTDITPQGVAMRAGVLA-DDHLIEVNGENVED 190
+PR L K GF++ + +G++++ I G A +G L D ++ VNG ++
Sbjct: 523 EPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRG 582
Query: 191 ASHEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRETASLKLLPHQPRIVEMKKGS 250
ASHE+ +K +G V + + D E KI RE +++ H M GS
Sbjct: 583 ASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLRE----QMMNH-----SMSSGS 633
Query: 251 NGY------GFYLRAGSEQKGQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVE 297
Y+RA + K DSG P++ K D++ +N E
Sbjct: 634 GSLRTNQKRSLYVRAMFDYD----KSKDSGLPSQGLSFKYGDILHVINASDDE 682
Score = 49.3 bits (116), Expect = 8e-06
Identities = 32/124 (25%), Positives = 60/124 (48%), Gaps = 5/124 (4%)
Query: 237 LPHQPRIVEMKKGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEAG-LKNNDLVVAVNGES 295
L +PR V + KGS G GF + G + +G + I +G PA+ +G L+ D +++VNG
Sbjct: 520 LEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGID 579
Query: 296 VETLDHDSVVEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVKEAPAP 355
+ H+ + KG QT ++ + ++ A F ++ +++ N S+
Sbjct: 580 LRGASHEQAAAAL-KGAGQTVTIIAQYQPED---YARFEAKIHDLREQMMNHSMSSGSGS 635
Query: 356 TPTS 359
T+
Sbjct: 636 LRTN 639
Score = 41.6 bits (96), Expect = 0.002
Identities = 23/83 (27%), Positives = 41/83 (49%), Gaps = 7/83 (8%)
Query: 244 VEMKKGSNGYGFYLRAGSEQKGQ-------IIKDIDSGSPAEEAGLKNNDLVVAVNGESV 296
+ +++G++G GF + G++ I K I G+ AE+ L+ ND ++ VN V
Sbjct: 204 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 263
Query: 297 ETLDHDSVVEMIRKGGDQTSLLV 319
+ H VE +++ G L V
Sbjct: 264 SEVSHSKAVEALKEAGSIVRLYV 286
Score = 38.5 bits (88), Expect = 0.015
Identities = 25/80 (31%), Positives = 42/80 (52%), Gaps = 2/80 (2%)
Query: 7 PRECKLSKQEGQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAG-LQDGDRVLRINGVFVDK 65
PR+ L K GF + +D EG V + PA+ +G LQ GD++L +NG+ +
Sbjct: 524 PRKVVLHKGS-TGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRG 582
Query: 66 EEHMQVVDLVRKSGNSVTLL 85
H Q ++ +G +VT++
Sbjct: 583 ASHEQAAAALKGAGQTVTII 602
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 80.9 bits (198), Expect = 3e-15
Identities = 100/436 (22%), Positives = 186/436 (42%), Gaps = 56/436 (12%)
Query: 34 LVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDLVRKSGNSVTLLVLDGDSYE 93
+ +++ + AE L+ D +LR+N V V + H + V+ ++++G+ V L V
Sbjct: 129 ITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVR---RRR 185
Query: 94 KAVKTRVDLKELGQSQKEQGLSDNILSPVMNGGVQTWTQPRLCYLVKEGGSYGFSLKTVQ 153
++T V++K L + K G S + GGV + +
Sbjct: 186 PILETVVEIK-LFKGPKGLGFS-------IAGGVGN--------------------QHIP 217
Query: 154 GKKGVYMTDITPQGVAMRAGVL-ADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLV 212
G +Y+T I G A + G L D L+ VN ++E+ +HEE V + K+ S V++L V
Sbjct: 218 GDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVA-ILKNTSEVVYLKV 276
Query: 213 DKETDKRHVEQKIQFKRETASLKLLPHQPRIVEMKKGSNGYGFYLRAGSEQKGQIIKDID 272
K T + P+ P + S +L +G+ + +
Sbjct: 277 GKPTTIYMTD---------------PYGPPDITHSY-SPPMENHLLSGNNGTLEYKTSLP 320
Query: 273 SGSPAEEAGLKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLVVDKETDNMYRLAH 332
SP + + + LV E + + +V ++ K V E D + L+
Sbjct: 321 PISPGRYSPIPKHMLVDDDYTRPPEPV-YSTVNKLCDKPASPRHYSPV--ECDKSFLLS- 376
Query: 333 FSPFLYYQSQELPNGSVKEAPAPTPTSLEVSSPPDTTEEVDHKPKLCRLAKGENGYGFHL 392
+P+ +Y LP+ + + + + S ++ +P+ L KG G GF++
Sbjct: 377 -APYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNI 435
Query: 393 NAIRGLPGSFIKEVQKGGPADLAG-LEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNVT 451
G F+ + GGPADL+G L+ D I+ VNG+++ +E+ ++ +G+ VT
Sbjct: 436 VGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVT 495
Query: 452 LLV-CGKKAYDYFQAK 466
++ + Y F+AK
Sbjct: 496 IIAQYQPEDYARFEAK 511
Score = 56.2 bits (134), Expect = 7e-08
Identities = 43/171 (25%), Positives = 76/171 (44%), Gaps = 28/171 (16%)
Query: 157 GVYMTDITPQGVAMRAGVL-ADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLVDKE 215
G+++T I P G A G L +D ++ VN +V + SH + VE +K++GS V
Sbjct: 126 GIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIV-------- 177
Query: 216 TDKRHVEQKIQFKRETASLKLLPHQPRIVEMKKGSNGYGFYLRAG-------SEQKGQII 268
+ +V ++ +KL KG G GF + G + +
Sbjct: 178 --RLYVRRRRPILETVVEIKLF----------KGPKGLGFSIAGGVGNQHIPGDNSIYVT 225
Query: 269 KDIDSGSPAEEAGLKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLV 319
K ID G+ ++ L+ D ++ VN S+E + H+ V +++ + L V
Sbjct: 226 KIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 276
Score = 50.1 bits (118), Expect = 5e-06
Identities = 45/173 (26%), Positives = 74/173 (42%), Gaps = 20/173 (11%)
Query: 132 QPRLCYLVKEGGSYGFSLKTVQGKKGVYMTDITPQGVAMRAGVLA-DDHLIEVNGENVED 190
+PR L K GF++ + +G++++ I G A +G L D ++ VNG ++
Sbjct: 418 EPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRG 477
Query: 191 ASHEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRETASLKLLPHQPRIVEMKKGS 250
ASHE+ +K +G V + + D E KI RE +++ H M GS
Sbjct: 478 ASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLRE----QMMNH-----SMSSGS 528
Query: 251 NGY------GFYLRAGSEQKGQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVE 297
Y+RA + K DSG P++ K D++ +N E
Sbjct: 529 GSLRTNQKRSLYVRAMFDYD----KSKDSGLPSQGLSFKYGDILHVINASDDE 577
Score = 49.3 bits (116), Expect = 8e-06
Identities = 32/124 (25%), Positives = 60/124 (48%), Gaps = 5/124 (4%)
Query: 237 LPHQPRIVEMKKGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEAG-LKNNDLVVAVNGES 295
L +PR V + KGS G GF + G + +G + I +G PA+ +G L+ D +++VNG
Sbjct: 415 LEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGID 474
Query: 296 VETLDHDSVVEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVKEAPAP 355
+ H+ + KG QT ++ + ++ A F ++ +++ N S+
Sbjct: 475 LRGASHEQAAAAL-KGAGQTVTIIAQYQPED---YARFEAKIHDLREQMMNHSMSSGSGS 530
Query: 356 TPTS 359
T+
Sbjct: 531 LRTN 534
Score = 41.6 bits (96), Expect = 0.002
Identities = 23/83 (27%), Positives = 41/83 (49%), Gaps = 7/83 (8%)
Query: 244 VEMKKGSNGYGFYLRAGSEQKGQ-------IIKDIDSGSPAEEAGLKNNDLVVAVNGESV 296
+ +++G++G GF + G++ I K I G+ AE+ L+ ND ++ VN V
Sbjct: 99 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 158
Query: 297 ETLDHDSVVEMIRKGGDQTSLLV 319
+ H VE +++ G L V
Sbjct: 159 SEVSHSKAVEALKEAGSIVRLYV 181
Score = 38.5 bits (88), Expect = 0.015
Identities = 25/80 (31%), Positives = 42/80 (52%), Gaps = 2/80 (2%)
Query: 7 PRECKLSKQEGQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAG-LQDGDRVLRINGVFVDK 65
PR+ L K GF + +D EG V + PA+ +G LQ GD++L +NG+ +
Sbjct: 419 PRKVVLHKGS-TGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRG 477
Query: 66 EEHMQVVDLVRKSGNSVTLL 85
H Q ++ +G +VT++
Sbjct: 478 ASHEQAAAALKGAGQTVTII 497
>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform c [Homo sapiens]
Length = 1462
Score = 79.3 bits (194), Expect = 8e-15
Identities = 137/611 (22%), Positives = 226/611 (36%), Gaps = 133/611 (21%)
Query: 21 GFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDLVRK--S 78
GF I G RV + GL++GD ++ +N V H QVVD++ +
Sbjct: 652 GFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPK 711
Query: 79 GNSVTLLVLDGD------SYEKAVKTRVDLKELGQSQKEQGLSDNILSPVMNGGV----- 127
G+ VTLLV G S + R D + Q S + SP + V
Sbjct: 712 GSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFP 771
Query: 128 ---------------------QTWTQPRLCY-------------LVKEGGSYGFS-LKTV 152
+ W Q R Y L ++ +GF L
Sbjct: 772 PAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRLPDYQEQDIFLWRKETGFGFRILGGN 831
Query: 153 QGKKGVYMTDITPQGVAMRAGVL-ADDHLIEVNGENVEDASHEEVVEKVKKSGS------ 205
+ + +Y+ I P G A G L + D LI V+G V SH+ VV+ ++++
Sbjct: 832 EPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNL 891
Query: 206 ----RVMFLLVDKETDKRHVEQKIQFKRETASL---KLLPH------------------- 239
+V+F + E + + ASL K P
Sbjct: 892 TVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGI 951
Query: 240 ---------------QPRIVEMKKGSN-GYGFYL-------RAGS----------EQKGQ 266
QP VE+++G N G+GF + AG+ + G+
Sbjct: 952 GSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGR 1011
Query: 267 IIKDIDSGSPAEEAG-LKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLVVD-KET 324
II+ GSPA+ G LK D ++AVNG S+ H +V +I++ G+ +L ++ E+
Sbjct: 1012 IIE----GSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDES 1067
Query: 325 DNMYRLAHFSPFLYYQSQELPNGS----VKEAPAPTPTSLEVSSPPDTTEEVDHKPKLCR 380
N L + + P+ + P S P T+E D
Sbjct: 1068 SNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYT--VE 1125
Query: 381 LAKGENGYGFHLNAIRGLPGS-FIKEVQKGGPADLAG-LEDEDVIIEVNGVNVLDEPYEK 438
L +G G+GF L R ++ + + GPA+ G + D I+E+NG + + +
Sbjct: 1126 LERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSR 1185
Query: 439 VVDRIQSSGKNVTLLV----CGKKAYDYFQAKKIPIVSSLADP-LDTPPDSKEGIVVESN 493
++ I++ G+ V L + YD + P P + PD ++ +ES+
Sbjct: 1186 AIELIKNGGRRVRLFLKRGDGSVPEYDPSSDRHGPATGPQGVPEVRAGPDRRQHPSLESS 1245
Query: 494 HDSHMAKERAH 504
+ + K H
Sbjct: 1246 YPPDLHKSSPH 1256
Score = 78.6 bits (192), Expect = 1e-14
Identities = 60/240 (25%), Positives = 111/240 (46%), Gaps = 29/240 (12%)
Query: 1 MTSTFNPRECKLSKQEGQNYGFFL-----RIEKDTE--------GHLVRVVEKCSPAEKA 47
+++ P + ++ + E + +GF + R E T H + + + SPA++
Sbjct: 962 VSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRC 1021
Query: 48 G-LQDGDRVLRINGVFVDKEEHMQVVDLVRKSGNSVTLLVLDGDSYEKAV----KTRVDL 102
G L+ GDR+L +NG + + H +V+L++++GN+VTL ++ GD A ++
Sbjct: 1022 GKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIAT 1081
Query: 103 KELGQSQKEQGLSD--NILSPVMNGGVQ----TWTQPRLCYLVK-EGGSYGFSLKTVQGK 155
+ +QG + N P + TQ + Y V+ E G+ GF G+
Sbjct: 1082 ITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGR 1141
Query: 156 K---GVYMTDITPQGVAMRAGVL-ADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLL 211
+ +Y+ + G A R G + D ++E+NGE ++ H +E +K G RV L
Sbjct: 1142 EYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFL 1201
Score = 62.4 bits (150), Expect = 1e-09
Identities = 63/262 (24%), Positives = 105/262 (40%), Gaps = 49/262 (18%)
Query: 169 AMRAGVL-ADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLVD-------------- 213
A R G L D ++ VNG ++ + SH ++V +K++G+ V ++
Sbjct: 1018 ADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAE 1077
Query: 214 -------------------KETDKRHVEQKIQFKRETASLKLLPHQPRIVEMKKGSNGYG 254
+ T K E + +FK A+ + VE+++G+ G+G
Sbjct: 1078 KIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQE---QDFYTVELERGAKGFG 1134
Query: 255 FYLRAGSEQKGQI-IKDIDSGSPAEEAG-LKNNDLVVAVNGESVETLDHDSVVEMIRKGG 312
F LR G E + + + PAE G ++ D ++ +NGE+ + + H +E+I+ GG
Sbjct: 1135 FSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGG 1194
Query: 313 DQTSLLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVKEAPAPTP----TSLEVSSPPDT 368
+ L + K D + + P V E A SLE S PPD
Sbjct: 1195 RRVRLFL--KRGDG--SVPEYDPSSDRHGPATGPQGVPEVRAGPDRRQHPSLESSYPPDL 1250
Query: 369 TEEVDHKPKL--CRLAKGENGY 388
+ H K R KG Y
Sbjct: 1251 HKSSPHGEKRAHARDPKGSREY 1272
Score = 61.2 bits (147), Expect = 2e-09
Identities = 99/389 (25%), Positives = 153/389 (39%), Gaps = 72/389 (18%)
Query: 175 LADDHLIEVNGENVED--ASHEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRETA 232
+ D I VNG+ D ASH KV D ++ H + +T
Sbjct: 575 ILDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSH-----GYPNDTV 629
Query: 233 SL-KLLPHQPRI--VEMKKGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEAGLKNNDLVV 289
SL + QP + V + KG G+GF + GQ +K I GLK DL+V
Sbjct: 630 SLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCR--GLKEGDLIV 687
Query: 290 AVNGESVETLDHDSVVEMI---RKGGDQTSL-----LVVDKETD---------------- 325
VN ++V+ L H+ VV+M+ KG + T L L V K++
Sbjct: 688 EVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQH 747
Query: 326 --NMYRLAH-FSPFLYYQSQELPNGSVKEAPAPTPTSLEVSSPPD------------TTE 370
+ +R H SP + +Q LP EA AP T PD
Sbjct: 748 SVSSHRSLHTASP--SHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENR 805
Query: 371 EVDHKPKLCRLAKGENGYGFHLNAIRGLPGS--FIKEVQKGGPADLAG-LEDEDVIIEVN 427
D++ + L + E G+GF + PG +I + G AD G L D +I V+
Sbjct: 806 LPDYQEQDIFLWRKETGFGFRILG-GNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVD 864
Query: 428 GVNVLDEPYEKVVDRIQSSGK--NVTLLVCGKKAYDYFQAKKIPIVSSLADPLDTPPDSK 485
G V+ + ++ VV +Q + K +V L V + K + V + + +P S
Sbjct: 865 GTPVIGKSHQLVVQLMQQAAKQGHVNLTV---------RRKVVFAVPKTENEVPSPASSH 915
Query: 486 EGIVVESNHDSHMAKERAHSTASHSSSNS 514
SN + + +E+ S +S N+
Sbjct: 916 H----SSNQPASLTEEKRTPQGSQNSLNT 940
Score = 53.5 bits (127), Expect = 5e-07
Identities = 71/300 (23%), Positives = 119/300 (39%), Gaps = 47/300 (15%)
Query: 245 EMKKGSNGYGFYLRAGSEQKG--QIIKDIDSGSPAEEAGLKNNDLVVAVNGESVETLDHD 302
+++K S G+GF + G E QI + G A + ++ D++V+VN V H
Sbjct: 474 KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHA 533
Query: 303 SVVEMIRK---GGD----------------------QTSLLVVDKETDNMYRLAHFSPFL 337
VV++ + G TS+ ++DKE + +
Sbjct: 534 QVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPA 593
Query: 338 YYQSQELPNGSVKEAPAPTPTSLEVSS----PPDT---TEEVDHKPKL--CRLAKGENGY 388
+ S+ +K+A +P + +S P DT + +P+L + KG G+
Sbjct: 594 SHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGF 653
Query: 389 GFHLNAIRGLPGSFIKEVQKGGPADLAGLEDEDVIIEVNGVNVLDEPYEKVVDRIQS--S 446
GF + G G +K++ GL++ D+I+EVN NV + +VVD +
Sbjct: 654 GFTIADSPGGGGQRVKQIVDS--PRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPK 711
Query: 447 GKNVTLLVCGKKAYDYFQAKKIPIVSSLADPLDTPPDSKEGIVVESNHDSHMAKERAHST 506
G VTLLV +P S + PL+ S+H S +HST
Sbjct: 712 GSEVTLLV-------QRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHST 764
Score = 40.8 bits (94), Expect = 0.003
Identities = 24/76 (31%), Positives = 43/76 (56%), Gaps = 4/76 (5%)
Query: 18 QNYGFFLR--IEKDTEGHLVRVVEKCSPAEKAG-LQDGDRVLRINGVFVDKEEHMQVVDL 74
+ +GF LR E + + +++R+ E PAE+ G ++ GD +L ING +H + ++L
Sbjct: 1131 KGFGFSLRGGREYNMDLYVLRLAED-GPAERCGKMRIGDEILEINGETTKNMKHSRAIEL 1189
Query: 75 VRKSGNSVTLLVLDGD 90
++ G V L + GD
Sbjct: 1190 IKNGGRRVRLFLKRGD 1205
Score = 33.1 bits (74), Expect = 0.63
Identities = 26/87 (29%), Positives = 46/87 (52%), Gaps = 10/87 (11%)
Query: 131 TQPRLC--YLVKEGGSYGFSLKTVQGKKGVYMTDI--TPQGVAMRAGVLADDHLIEVNGE 186
TQP L ++VK +GF++ G G + I +P+ ++ G D ++EVN +
Sbjct: 637 TQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEG----DLIVEVNKK 692
Query: 187 NVEDASHEEVVEKVKK--SGSRVMFLL 211
NV+ +H +VV+ + + GS V L+
Sbjct: 693 NVQALTHNQVVDMLVECPKGSEVTLLV 719
>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform a [Homo sapiens]
Length = 1287
Score = 78.6 bits (192), Expect = 1e-14
Identities = 60/240 (25%), Positives = 111/240 (46%), Gaps = 29/240 (12%)
Query: 1 MTSTFNPRECKLSKQEGQNYGFFL-----RIEKDTE--------GHLVRVVEKCSPAEKA 47
+++ P + ++ + E + +GF + R E T H + + + SPA++
Sbjct: 990 VSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRC 1049
Query: 48 G-LQDGDRVLRINGVFVDKEEHMQVVDLVRKSGNSVTLLVLDGDSYEKAV----KTRVDL 102
G L+ GDR+L +NG + + H +V+L++++GN+VTL ++ GD A ++
Sbjct: 1050 GKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIAT 1109
Query: 103 KELGQSQKEQGLSD--NILSPVMNGGVQ----TWTQPRLCYLVK-EGGSYGFSLKTVQGK 155
+ +QG + N P + TQ + Y V+ E G+ GF G+
Sbjct: 1110 ITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGR 1169
Query: 156 K---GVYMTDITPQGVAMRAGVL-ADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLL 211
+ +Y+ + G A R G + D ++E+NGE ++ H +E +K G RV L
Sbjct: 1170 EYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFL 1229
Score = 70.5 bits (171), Expect = 4e-12
Identities = 90/386 (23%), Positives = 154/386 (39%), Gaps = 83/386 (21%)
Query: 146 GFSLKTVQGKKG---VYMTDITPQGVAMRAGVL-ADDHLIEVNGENVEDASHEEVVEKVK 201
GF + + G + +Y+ I P G A G L + D LI V+G V SH+ VV+ ++
Sbjct: 850 GFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQ 909
Query: 202 KSGS----------RVMFLLVDKETDKRHVEQKIQFKRETASL---KLLPH--------- 239
++ +V+F + E + + ASL K P
Sbjct: 910 QAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTV 969
Query: 240 -------------------------QPRIVEMKKGSN-GYGFYL-------RAGS----- 261
QP VE+++G N G+GF + AG+
Sbjct: 970 SSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNA 1029
Query: 262 -----EQKGQIIKDIDSGSPAEEAG-LKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQT 315
+ G+II+ GSPA+ G LK D ++AVNG S+ H +V +I++ G+
Sbjct: 1030 CVAMPHKIGRIIE----GSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTV 1085
Query: 316 SLLVVD-KETDNMYRLAHFSPFLYYQSQELPNGS----VKEAPAPTPTSLEVSSPPDTTE 370
+L ++ E+ N L + + P+ + P S P T+
Sbjct: 1086 TLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQ 1145
Query: 371 EVDHKPKLCRLAKGENGYGFHLNAIRGLPGS-FIKEVQKGGPADLAG-LEDEDVIIEVNG 428
E D L +G G+GF L R ++ + + GPA+ G + D I+E+NG
Sbjct: 1146 EQDFYT--VELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEING 1203
Query: 429 VNVLDEPYEKVVDRIQSSGKNVTLLV 454
+ + + ++ I++ G+ V L +
Sbjct: 1204 ETTKNMKHSRAIELIKNGGRRVRLFL 1229
Score = 53.5 bits (127), Expect = 5e-07
Identities = 71/300 (23%), Positives = 119/300 (39%), Gaps = 47/300 (15%)
Query: 245 EMKKGSNGYGFYLRAGSEQKG--QIIKDIDSGSPAEEAGLKNNDLVVAVNGESVETLDHD 302
+++K S G+GF + G E QI + G A + ++ D++V+VN V H
Sbjct: 474 KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHA 533
Query: 303 SVVEMIRK---GGD----------------------QTSLLVVDKETDNMYRLAHFSPFL 337
VV++ + G TS+ ++DKE + +
Sbjct: 534 QVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPA 593
Query: 338 YYQSQELPNGSVKEAPAPTPTSLEVSS----PPDT---TEEVDHKPKL--CRLAKGENGY 388
+ S+ +K+A +P + +S P DT + +P+L + KG G+
Sbjct: 594 SHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGF 653
Query: 389 GFHLNAIRGLPGSFIKEVQKGGPADLAGLEDEDVIIEVNGVNVLDEPYEKVVDRIQS--S 446
GF + G G +K++ GL++ D+I+EVN NV + +VVD +
Sbjct: 654 GFTIADSPGGGGQRVKQIVDS--PRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPK 711
Query: 447 GKNVTLLVCGKKAYDYFQAKKIPIVSSLADPLDTPPDSKEGIVVESNHDSHMAKERAHST 506
G VTLLV +P S + PL+ S+H S +HST
Sbjct: 712 GSEVTLLV-------QRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHST 764
Score = 51.2 bits (121), Expect = 2e-06
Identities = 100/417 (23%), Positives = 154/417 (36%), Gaps = 100/417 (23%)
Query: 175 LADDHLIEVNGENVED--ASHEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRETA 232
+ D I VNG+ D ASH KV D ++ H + +T
Sbjct: 575 ILDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSH-----GYPNDTV 629
Query: 233 SL-KLLPHQPRI--VEMKKGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEAGLKNNDLVV 289
SL + QP + V + KG G+GF + GQ +K I GLK DL+V
Sbjct: 630 SLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCR--GLKEGDLIV 687
Query: 290 AVNGESVETLDHDSVVEMI---RKGGDQTSL-----LVVDKETD---------------- 325
VN ++V+ L H+ VV+M+ KG + T L L V K++
Sbjct: 688 EVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQH 747
Query: 326 --NMYRLAH-FSPFLYYQSQELPNGSVKEAPAPTPTSLEVSSPPD-------TTEEVDHK 375
+ +R H SP + +Q LP EA AP T PD + +++
Sbjct: 748 SVSSHRSLHTASP--SHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENR 805
Query: 376 PKLCRLAKG---------------------------------ENGYGFHLNAIRGLPGS- 401
P A G E G+GF + PG
Sbjct: 806 PMSPSPASGLSKGEREREINSTNFGECPIPDYQEQDIFLWRKETGFGFRILG-GNEPGEP 864
Query: 402 -FIKEVQKGGPADLAG-LEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGK--NVTLLVCGK 457
+I + G AD G L D +I V+G V+ + ++ VV +Q + K +V L V
Sbjct: 865 IYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTV--- 921
Query: 458 KAYDYFQAKKIPIVSSLADPLDTPPDSKEGIVVESNHDSHMAKERAHSTASHSSSNS 514
+ K + V + + +P S SN + + +E+ S +S N+
Sbjct: 922 ------RRKVVFAVPKTENEVPSPASSHH----SSNQPASLTEEKRTPQGSQNSLNT 968
Score = 47.4 bits (111), Expect = 3e-05
Identities = 62/258 (24%), Positives = 111/258 (43%), Gaps = 47/258 (18%)
Query: 239 HQPRIVEMKKGSNGYGFYLRAGSEQKGQIIKD--IDSGSPAEEAGLKNNDLVVAVNGESV 296
+Q + + + + G+GF + G+E I + G+ + L++ D ++ V+G V
Sbjct: 837 YQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPV 896
Query: 297 ETLDHDSVVEMIRKGGDQ--TSLLVVDK------ETDNMYRLAHFSPFLYYQSQELPNGS 348
H VV+++++ Q +L V K +T+N SP + S P
Sbjct: 897 IGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVP----SPASSHHSSNQPASL 952
Query: 349 VKEAPAP--TPTSLE-VSSPPDTTEEVDH-------------KPKLCRLAKGEN-GYGFH 391
+E P + SL VSS +T + +P + +GEN G+GF
Sbjct: 953 TEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFV 1012
Query: 392 L--------------NAIRGLPGSFIKEVQKGGPADLAG-LEDEDVIIEVNGVNVLDEPY 436
+ NA +P I + +G PAD G L+ D I+ VNG ++ ++ +
Sbjct: 1013 IVSSVSRPEAGTTFGNACVAMPHK-IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSH 1071
Query: 437 EKVVDRIQSSGKNVTLLV 454
+V+ I+ +G VTL +
Sbjct: 1072 SDIVNLIKEAGNTVTLRI 1089
Score = 40.8 bits (94), Expect = 0.003
Identities = 24/76 (31%), Positives = 43/76 (56%), Gaps = 4/76 (5%)
Query: 18 QNYGFFLR--IEKDTEGHLVRVVEKCSPAEKAG-LQDGDRVLRINGVFVDKEEHMQVVDL 74
+ +GF LR E + + +++R+ E PAE+ G ++ GD +L ING +H + ++L
Sbjct: 1159 KGFGFSLRGGREYNMDLYVLRLAED-GPAERCGKMRIGDEILEINGETTKNMKHSRAIEL 1217
Query: 75 VRKSGNSVTLLVLDGD 90
++ G V L + GD
Sbjct: 1218 IKNGGRRVRLFLKRGD 1233
Score = 33.5 bits (75), Expect = 0.48
Identities = 24/71 (33%), Positives = 34/71 (47%), Gaps = 2/71 (2%)
Query: 21 GFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDLVRK--S 78
GF I G RV + GL++GD ++ +N V H QVVD++ +
Sbjct: 652 GFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPK 711
Query: 79 GNSVTLLVLDG 89
G+ VTLLV G
Sbjct: 712 GSEVTLLVQRG 722
Score = 33.1 bits (74), Expect = 0.63
Identities = 26/87 (29%), Positives = 46/87 (52%), Gaps = 10/87 (11%)
Query: 131 TQPRLC--YLVKEGGSYGFSLKTVQGKKGVYMTDI--TPQGVAMRAGVLADDHLIEVNGE 186
TQP L ++VK +GF++ G G + I +P+ ++ G D ++EVN +
Sbjct: 637 TQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEG----DLIVEVNKK 692
Query: 187 NVEDASHEEVVEKVKK--SGSRVMFLL 211
NV+ +H +VV+ + + GS V L+
Sbjct: 693 NVQALTHNQVVDMLVECPKGSEVTLLV 719
>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform b [Homo sapiens]
Length = 1256
Score = 78.2 bits (191), Expect = 2e-14
Identities = 60/241 (24%), Positives = 111/241 (46%), Gaps = 30/241 (12%)
Query: 1 MTSTFNPRECKLSKQEGQNYGFFL-----RIEKDTE---------GHLVRVVEKCSPAEK 46
+++ P + ++ + E + +GF + R E T H + + + SPA++
Sbjct: 990 VSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFAGNACVAMPHKIGRIIEGSPADR 1049
Query: 47 AG-LQDGDRVLRINGVFVDKEEHMQVVDLVRKSGNSVTLLVLDGDSYEKAV----KTRVD 101
G L+ GDR+L +NG + + H +V+L++++GN+VTL ++ GD A ++
Sbjct: 1050 CGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIA 1109
Query: 102 LKELGQSQKEQGLSD--NILSPVMNGGVQ----TWTQPRLCYLVK-EGGSYGFSLKTVQG 154
+ +QG + N P + TQ + Y V+ E G+ GF G
Sbjct: 1110 TITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGG 1169
Query: 155 KK---GVYMTDITPQGVAMRAGVL-ADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFL 210
++ +Y+ + G A R G + D ++E+NGE ++ H +E +K G RV
Sbjct: 1170 REYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLF 1229
Query: 211 L 211
L
Sbjct: 1230 L 1230
Score = 72.4 bits (176), Expect = 9e-13
Identities = 90/383 (23%), Positives = 151/383 (39%), Gaps = 76/383 (19%)
Query: 146 GFSLKTVQGKKG---VYMTDITPQGVAMRAGVL-ADDHLIEVNGENVEDASHEEVVEKVK 201
GF + + G + +Y+ I P G A G L + D LI V+G V SH+ VV+ ++
Sbjct: 850 GFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQ 909
Query: 202 KSGS----------RVMFLLVDKETDKRHVEQKIQFKRETASL---KLLPH--------- 239
++ +V+F + E + + ASL K P
Sbjct: 910 QAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTV 969
Query: 240 -------------------------QPRIVEMKKGSN-GYGFYL-------RAGSEQKGQ 266
QP VE+++G N G+GF + AG+ G
Sbjct: 970 SSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFAGN 1029
Query: 267 I-------IKDIDSGSPAEEAG-LKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLL 318
I I GSPA+ G LK D ++AVNG S+ H +V +I++ G+ +L
Sbjct: 1030 ACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLR 1089
Query: 319 VVD-KETDNMYRLAHFSPFLYYQSQELPNGS----VKEAPAPTPTSLEVSSPPDTTEEVD 373
++ E+ N L + + P+ + P S P T+E D
Sbjct: 1090 IIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQD 1149
Query: 374 HKPKLCRLAKGENGYGFHLNAIRGLPGS-FIKEVQKGGPADLAG-LEDEDVIIEVNGVNV 431
L +G G+GF L R ++ + + GPA+ G + D I+E+NG
Sbjct: 1150 FYT--VELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETT 1207
Query: 432 LDEPYEKVVDRIQSSGKNVTLLV 454
+ + + ++ I++ G+ V L +
Sbjct: 1208 KNMKHSRAIELIKNGGRRVRLFL 1230
Score = 53.5 bits (127), Expect = 5e-07
Identities = 71/300 (23%), Positives = 119/300 (39%), Gaps = 47/300 (15%)
Query: 245 EMKKGSNGYGFYLRAGSEQKG--QIIKDIDSGSPAEEAGLKNNDLVVAVNGESVETLDHD 302
+++K S G+GF + G E QI + G A + ++ D++V+VN V H
Sbjct: 474 KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHA 533
Query: 303 SVVEMIRK---GGD----------------------QTSLLVVDKETDNMYRLAHFSPFL 337
VV++ + G TS+ ++DKE + +
Sbjct: 534 QVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPA 593
Query: 338 YYQSQELPNGSVKEAPAPTPTSLEVSS----PPDT---TEEVDHKPKL--CRLAKGENGY 388
+ S+ +K+A +P + +S P DT + +P+L + KG G+
Sbjct: 594 SHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGF 653
Query: 389 GFHLNAIRGLPGSFIKEVQKGGPADLAGLEDEDVIIEVNGVNVLDEPYEKVVDRIQS--S 446
GF + G G +K++ GL++ D+I+EVN NV + +VVD +
Sbjct: 654 GFTIADSPGGGGQRVKQIVDS--PRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPK 711
Query: 447 GKNVTLLVCGKKAYDYFQAKKIPIVSSLADPLDTPPDSKEGIVVESNHDSHMAKERAHST 506
G VTLLV +P S + PL+ S+H S +HST
Sbjct: 712 GSEVTLLV-------QRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHST 764
Score = 51.2 bits (121), Expect = 2e-06
Identities = 100/417 (23%), Positives = 154/417 (36%), Gaps = 100/417 (23%)
Query: 175 LADDHLIEVNGENVED--ASHEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRETA 232
+ D I VNG+ D ASH KV D ++ H + +T
Sbjct: 575 ILDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSH-----GYPNDTV 629
Query: 233 SL-KLLPHQPRI--VEMKKGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEAGLKNNDLVV 289
SL + QP + V + KG G+GF + GQ +K I GLK DL+V
Sbjct: 630 SLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCR--GLKEGDLIV 687
Query: 290 AVNGESVETLDHDSVVEMI---RKGGDQTSL-----LVVDKETD---------------- 325
VN ++V+ L H+ VV+M+ KG + T L L V K++
Sbjct: 688 EVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQH 747
Query: 326 --NMYRLAH-FSPFLYYQSQELPNGSVKEAPAPTPTSLEVSSPPD-------TTEEVDHK 375
+ +R H SP + +Q LP EA AP T PD + +++
Sbjct: 748 SVSSHRSLHTASP--SHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENR 805
Query: 376 PKLCRLAKG---------------------------------ENGYGFHLNAIRGLPGS- 401
P A G E G+GF + PG
Sbjct: 806 PMSPSPASGLSKGEREREINSTNFGECPIPDYQEQDIFLWRKETGFGFRILG-GNEPGEP 864
Query: 402 -FIKEVQKGGPADLAG-LEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGK--NVTLLVCGK 457
+I + G AD G L D +I V+G V+ + ++ VV +Q + K +V L V
Sbjct: 865 IYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTV--- 921
Query: 458 KAYDYFQAKKIPIVSSLADPLDTPPDSKEGIVVESNHDSHMAKERAHSTASHSSSNS 514
+ K + V + + +P S SN + + +E+ S +S N+
Sbjct: 922 ------RRKVVFAVPKTENEVPSPASSHH----SSNQPASLTEEKRTPQGSQNSLNT 968
Score = 47.0 bits (110), Expect = 4e-05
Identities = 62/259 (23%), Positives = 111/259 (42%), Gaps = 48/259 (18%)
Query: 239 HQPRIVEMKKGSNGYGFYLRAGSEQKGQIIKD--IDSGSPAEEAGLKNNDLVVAVNGESV 296
+Q + + + + G+GF + G+E I + G+ + L++ D ++ V+G V
Sbjct: 837 YQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPV 896
Query: 297 ETLDHDSVVEMIRKGGDQ--TSLLVVDK------ETDNMYRLAHFSPFLYYQSQELPNGS 348
H VV+++++ Q +L V K +T+N SP + S P
Sbjct: 897 IGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVP----SPASSHHSSNQPASL 952
Query: 349 VKEAPAP--TPTSLE-VSSPPDTTEEVDH-------------KPKLCRLAKGEN-GYGFH 391
+E P + SL VSS +T + +P + +GEN G+GF
Sbjct: 953 TEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFV 1012
Query: 392 L---------------NAIRGLPGSFIKEVQKGGPADLAG-LEDEDVIIEVNGVNVLDEP 435
+ NA +P I + +G PAD G L+ D I+ VNG ++ ++
Sbjct: 1013 IVSSVSRPEAGTTFAGNACVAMPHK-IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKS 1071
Query: 436 YEKVVDRIQSSGKNVTLLV 454
+ +V+ I+ +G VTL +
Sbjct: 1072 HSDIVNLIKEAGNTVTLRI 1090
Score = 40.8 bits (94), Expect = 0.003
Identities = 24/76 (31%), Positives = 43/76 (56%), Gaps = 4/76 (5%)
Query: 18 QNYGFFLR--IEKDTEGHLVRVVEKCSPAEKAG-LQDGDRVLRINGVFVDKEEHMQVVDL 74
+ +GF LR E + + +++R+ E PAE+ G ++ GD +L ING +H + ++L
Sbjct: 1160 KGFGFSLRGGREYNMDLYVLRLAED-GPAERCGKMRIGDEILEINGETTKNMKHSRAIEL 1218
Query: 75 VRKSGNSVTLLVLDGD 90
++ G V L + GD
Sbjct: 1219 IKNGGRRVRLFLKRGD 1234
Score = 33.5 bits (75), Expect = 0.48
Identities = 24/71 (33%), Positives = 34/71 (47%), Gaps = 2/71 (2%)
Query: 21 GFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDLVRK--S 78
GF I G RV + GL++GD ++ +N V H QVVD++ +
Sbjct: 652 GFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPK 711
Query: 79 GNSVTLLVLDG 89
G+ VTLLV G
Sbjct: 712 GSEVTLLVQRG 722
Score = 33.1 bits (74), Expect = 0.63
Identities = 26/87 (29%), Positives = 46/87 (52%), Gaps = 10/87 (11%)
Query: 131 TQPRLC--YLVKEGGSYGFSLKTVQGKKGVYMTDI--TPQGVAMRAGVLADDHLIEVNGE 186
TQP L ++VK +GF++ G G + I +P+ ++ G D ++EVN +
Sbjct: 637 TQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEG----DLIVEVNKK 692
Query: 187 NVEDASHEEVVEKVKK--SGSRVMFLL 211
NV+ +H +VV+ + + GS V L+
Sbjct: 693 NVQALTHNQVVDMLVECPKGSEVTLLV 719
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 77.0 bits (188), Expect = 4e-14
Identities = 92/360 (25%), Positives = 151/360 (41%), Gaps = 44/360 (12%)
Query: 138 LVKEGGSYGFSLKTVQGK-------KGVYMTDITPQGVAMRAGVLADDHLIEVNGENVED 190
++++ G G S+ +G +G++++ ++ +G A RAGV D L+EVNG ++
Sbjct: 731 ILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQG 790
Query: 191 ASHEEVVEKVKKSGSRVMF-----LLVDKE-----TDKRHVEQKIQFKRETASLK--LLP 238
A H E VE ++ +G+ V +V+ E T R + +R L+ LLP
Sbjct: 791 AEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLP 850
Query: 239 -------HQPRIVEMKKGSNGYGFYLRAG-------SEQKGQIIKDIDSGSPAEEAG-LK 283
Q + + + G GF + G + G + I G A AG L+
Sbjct: 851 PESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQ 910
Query: 284 NNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLVVDKETDNMY---RLAHFSP---FL 337
D V+++NG V HD V ++ T L++++E L H SP +
Sbjct: 911 VGDRVLSINGVDVTEARHDHAVSLL-TAASPTIALLLEREAGGPLPPSPLPHSSPPTAAV 969
Query: 338 YYQSQELPNGSVKEAPAPTPTSLEVS-SPPDTTEEVDHKPKLCRLAKGENGYGFHLNAIR 396
S V P+ P+ L + P EE+ L G H +
Sbjct: 970 ATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPF 1029
Query: 397 GL--PGSFIKEVQKGGPADLAGLEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTLLV 454
G+ PG FI +V G A +GL D I+ VNG +V D +++ V + ++LLV
Sbjct: 1030 GVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLV 1089
Score = 73.6 bits (179), Expect = 4e-13
Identities = 76/340 (22%), Positives = 140/340 (41%), Gaps = 53/340 (15%)
Query: 29 DTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDLVRKSGNSVTLLV-- 86
D EG + V + PA +AG++ GD++L +NGV + EH + V+ +R +G +V + V
Sbjct: 754 DDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWR 813
Query: 87 ---LDGDSYEKAVKTRVDLKELGQSQKEQGLSDNILSPVMNGGVQTWTQPRLCYLVKEGG 143
++ ++ R + + ++ GL +L P G ++ Q + L +
Sbjct: 814 ERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLPPESPGPLR---QRHVACLARSER 870
Query: 144 SYGFSLKTVQGK-------KGVYMTDITPQGVAMRAGVL-ADDHLIEVNGENVEDASHEE 195
GFS+ +G G++++ I G A RAG L D ++ +NG +V +A H+
Sbjct: 871 GLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDH 930
Query: 196 VVEKVKKSGSRVMFLLVDKE-------TDKRHVEQKIQFKRETASLKLLPHQPRI----- 243
V + + S + LL+++E + H T+ P P +
Sbjct: 931 AV-SLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAP 989
Query: 244 ---------------VEMKKGSNGYGFYLRAGS---------EQKGQIIKDIDSGSPAEE 279
+ + + G + GS ++ G I + A
Sbjct: 990 SLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAAR 1049
Query: 280 AGLKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLV 319
+GL+ D ++AVNG+ V H V + + + SLLV
Sbjct: 1050 SGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLV 1089
Score = 72.0 bits (175), Expect = 1e-12
Identities = 76/309 (24%), Positives = 138/309 (44%), Gaps = 28/309 (9%)
Query: 32 GHLVRVVEKCSPAEKAG-LQDGDRVLRINGVFVDKEEHMQVVDLVRKSGNSVTLLV---- 86
G V + + A +AG LQ GDRVL INGV V + H V L+ + ++ LL+
Sbjct: 891 GIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREA 950
Query: 87 --------LDGDSYEKAVKTRVDLKELGQSQKE-QGLSDNILSPVMNGG--VQTWTQPRL 135
L S A + L+ ++L+ + G V+ PR
Sbjct: 951 GGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRA 1010
Query: 136 ---CYLVKEGGSYGFSLKTVQGKKGVYMTDITPQGVAMRAGVLADDHLIEVNGENVEDAS 192
L GGS S + GV+++ + P+G+A R+G+ D ++ VNG++V DA+
Sbjct: 1011 GGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDAT 1070
Query: 193 HEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRETASLKLLPHQPRIVEMKKGSNG 252
H+E V + + + LLV ++ + + ++ P + + ++ G+ G
Sbjct: 1071 HQEAVSALLRPCLELS-LLVRRDPAPPGLRE--------LCIQKAPGERLGISIRGGARG 1121
Query: 253 YGFYLRAGSEQKGQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVETLDHDSVVEMIRKGG 312
+ R +++ I K +G+ + L+ ++ VN +S+ L H V+++R G
Sbjct: 1122 HAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVG 1181
Query: 313 DQTSLLVVD 321
D ++LV D
Sbjct: 1182 DTLTVLVCD 1190
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 77.0 bits (188), Expect = 4e-14
Identities = 92/360 (25%), Positives = 151/360 (41%), Gaps = 44/360 (12%)
Query: 138 LVKEGGSYGFSLKTVQGK-------KGVYMTDITPQGVAMRAGVLADDHLIEVNGENVED 190
++++ G G S+ +G +G++++ ++ +G A RAGV D L+EVNG ++
Sbjct: 731 ILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQG 790
Query: 191 ASHEEVVEKVKKSGSRVMF-----LLVDKE-----TDKRHVEQKIQFKRETASLK--LLP 238
A H E VE ++ +G+ V +V+ E T R + +R L+ LLP
Sbjct: 791 AEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLP 850
Query: 239 -------HQPRIVEMKKGSNGYGFYLRAG-------SEQKGQIIKDIDSGSPAEEAG-LK 283
Q + + + G GF + G + G + I G A AG L+
Sbjct: 851 PESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQ 910
Query: 284 NNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLVVDKETDNMY---RLAHFSP---FL 337
D V+++NG V HD V ++ T L++++E L H SP +
Sbjct: 911 VGDRVLSINGVDVTEARHDHAVSLL-TAASPTIALLLEREAGGPLPPSPLPHSSPPTAAV 969
Query: 338 YYQSQELPNGSVKEAPAPTPTSLEVS-SPPDTTEEVDHKPKLCRLAKGENGYGFHLNAIR 396
S V P+ P+ L + P EE+ L G H +
Sbjct: 970 ATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPF 1029
Query: 397 GL--PGSFIKEVQKGGPADLAGLEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTLLV 454
G+ PG FI +V G A +GL D I+ VNG +V D +++ V + ++LLV
Sbjct: 1030 GVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLV 1089
Score = 73.6 bits (179), Expect = 4e-13
Identities = 76/340 (22%), Positives = 140/340 (41%), Gaps = 53/340 (15%)
Query: 29 DTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDLVRKSGNSVTLLV-- 86
D EG + V + PA +AG++ GD++L +NGV + EH + V+ +R +G +V + V
Sbjct: 754 DDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWR 813
Query: 87 ---LDGDSYEKAVKTRVDLKELGQSQKEQGLSDNILSPVMNGGVQTWTQPRLCYLVKEGG 143
++ ++ R + + ++ GL +L P G ++ Q + L +
Sbjct: 814 ERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLPPESPGPLR---QRHVACLARSER 870
Query: 144 SYGFSLKTVQGK-------KGVYMTDITPQGVAMRAGVL-ADDHLIEVNGENVEDASHEE 195
GFS+ +G G++++ I G A RAG L D ++ +NG +V +A H+
Sbjct: 871 GLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDH 930
Query: 196 VVEKVKKSGSRVMFLLVDKE-------TDKRHVEQKIQFKRETASLKLLPHQPRI----- 243
V + + S + LL+++E + H T+ P P +
Sbjct: 931 AV-SLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAP 989
Query: 244 ---------------VEMKKGSNGYGFYLRAGS---------EQKGQIIKDIDSGSPAEE 279
+ + + G + GS ++ G I + A
Sbjct: 990 SLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAAR 1049
Query: 280 AGLKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLV 319
+GL+ D ++AVNG+ V H V + + + SLLV
Sbjct: 1050 SGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLV 1089
Score = 72.0 bits (175), Expect = 1e-12
Identities = 76/309 (24%), Positives = 138/309 (44%), Gaps = 28/309 (9%)
Query: 32 GHLVRVVEKCSPAEKAG-LQDGDRVLRINGVFVDKEEHMQVVDLVRKSGNSVTLLV---- 86
G V + + A +AG LQ GDRVL INGV V + H V L+ + ++ LL+
Sbjct: 891 GIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREA 950
Query: 87 --------LDGDSYEKAVKTRVDLKELGQSQKE-QGLSDNILSPVMNGG--VQTWTQPRL 135
L S A + L+ ++L+ + G V+ PR
Sbjct: 951 GGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRA 1010
Query: 136 ---CYLVKEGGSYGFSLKTVQGKKGVYMTDITPQGVAMRAGVLADDHLIEVNGENVEDAS 192
L GGS S + GV+++ + P+G+A R+G+ D ++ VNG++V DA+
Sbjct: 1011 GGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDAT 1070
Query: 193 HEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRETASLKLLPHQPRIVEMKKGSNG 252
H+E V + + + LLV ++ + + ++ P + + ++ G+ G
Sbjct: 1071 HQEAVSALLRPCLELS-LLVRRDPAPPGLRE--------LCIQKAPGERLGISIRGGARG 1121
Query: 253 YGFYLRAGSEQKGQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVETLDHDSVVEMIRKGG 312
+ R +++ I K +G+ + L+ ++ VN +S+ L H V+++R G
Sbjct: 1122 HAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVG 1181
Query: 313 DQTSLLVVD 321
D ++LV D
Sbjct: 1182 DTLTVLVCD 1190
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 67.4 bits (163), Expect = 3e-11
Identities = 78/328 (23%), Positives = 135/328 (41%), Gaps = 45/328 (13%)
Query: 143 GSYGFSLKTVQGK----KGVYMTDITPQGVAMRAGVL-ADDHLIEVNGENVEDASHEEVV 197
G G L V GK + + ++ +G A R G L A D ++EVNG ++ ++SHEE +
Sbjct: 1443 GRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAI 1502
Query: 198 EKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRETASLKLLPHQPRIVEMKKGSNGYGFYL 257
++++ +V ++ D+ H R+ +L++ P + KK G G +
Sbjct: 1503 TALRQTPQKVRLVVY---RDEAHY-------RDEENLEIFP----VDLQKKAGRGLGLSI 1548
Query: 258 RAGSEQKGQIIKDIDSGSPAEEAG-LKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTS 316
G I DI G A+ G L D +++VNGE + ++V ++ K
Sbjct: 1549 VGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATIL-KCAQGLV 1607
Query: 317 LLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVKEAPAPTPTSLE-------VSSPPDTT 369
L + + + A + SQ+ + S + AP T L+ VS P
Sbjct: 1608 QLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKN 1667
Query: 370 EEVDHKPKLCRLAKG-ENGYGFHLNAIRGLP----GSFIKEVQKGG-PADLAGLEDEDVI 423
D +P+ + + + G + RG P FI +Q G A L+ D I
Sbjct: 1668 SGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRI 1727
Query: 424 IEVNG-----------VNVLDEPYEKVV 440
+ +NG VN+L Y +++
Sbjct: 1728 VSINGQPLDGLSHADVVNLLKNAYGRII 1755
Score = 61.6 bits (148), Expect = 2e-09
Identities = 79/369 (21%), Positives = 150/369 (40%), Gaps = 59/369 (15%)
Query: 143 GSYGFSLKTVQ----GKKGVYMTDITPQGVAMRAGVLAD-DHLIEVNGENVE-DASHEEV 196
G GFS+ ++ GK +++ D+ P VA R L + D ++ +N ++ + SH++
Sbjct: 143 GGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQA 202
Query: 197 VEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRETASLKLLPHQPRIVEMKKGSNGYGFY 256
+ ++++ + L+V +E T + VE+ +G GF
Sbjct: 203 IALLQQTTGSLR-LIVAREPVHTKSSTSSSLNDTTLPETVCWGHVEEVELINDGSGLGFG 261
Query: 257 LRAGSEQKGQIIKDIDSGSPAEEAG-LKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQT 315
+ G + G +++ I G A+ G L+ D ++ + G +V+ + + V +++R G+
Sbjct: 262 I-VGGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSV 320
Query: 316 SLLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVKEAPAPTPTSLEVSSP------PDTT 369
+LV P G + P P P +L V+ P P +
Sbjct: 321 RMLVARD----------------------PAGDISVTP-PAPAALPVALPTVASKGPGSD 357
Query: 370 EEVDHKPKLCRLAKGENGYGFHLNAIRG------LPGSFIKEVQKGGPADLAG-LEDEDV 422
+ + + K G + G G ++K + G A G ++ D
Sbjct: 358 SSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDK 417
Query: 423 IIEVNGVNVLDEPYEKVVDRIQSSGKNVTLLVCGKKAYDYFQAKKIPIVSSLADPLDTPP 482
I+ V+GVN+ VV+ ++++G+ V L + +K SS PL+ P
Sbjct: 418 IVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRK------------TSSSTSPLEPPS 465
Query: 483 DSKEGIVVE 491
D G VVE
Sbjct: 466 D--RGTVVE 472
Score = 58.9 bits (141), Expect = 1e-08
Identities = 74/331 (22%), Positives = 125/331 (37%), Gaps = 85/331 (25%)
Query: 37 VVEKCSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDLVRKSGNSVTLLVLDGDSY---- 92
V E+ + A L GD++L +NGV + H + + +R++ V L+V +++
Sbjct: 1467 VYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDE 1526
Query: 93 EKAVKTRVDLKELGQSQKEQGLSDNILSPVMNGGVQTWTQPRLCYLVKEGGSYGFSLKTV 152
E VDL++ K G G S+
Sbjct: 1527 ENLEIFPVDLQK-----------------------------------KAGRGLGLSIVGK 1551
Query: 153 QGKKGVYMTDITPQGVAMRAG-VLADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMF-- 209
+ GV+++DI G A G ++ D ++ VNGE++ +AS E V +K + V
Sbjct: 1552 RNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEI 1611
Query: 210 --LLVDKETDKRHVEQKIQFKRETASLKLLPH---------------------------- 239
L T R Q Q +++A P
Sbjct: 1612 GRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTD 1671
Query: 240 -QPRIVEMKKG-SNGYGFYLRAGSEQKGQIIKDID--------SGSPAEEAGLKNNDLVV 289
+PR VE+ + S+ G + G +G + DI SG A LK D +V
Sbjct: 1672 MEPRTVEINRELSDALGISIAGG---RGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIV 1728
Query: 290 AVNGESVETLDHDSVVEMIRKGGDQTSLLVV 320
++NG+ ++ L H VV +++ + L VV
Sbjct: 1729 SINGQPLDGLSHADVVNLLKNAYGRIILQVV 1759
Score = 56.2 bits (134), Expect = 7e-08
Identities = 58/213 (27%), Positives = 95/213 (44%), Gaps = 24/213 (11%)
Query: 16 EGQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAG-LQDGDRVLRINGVFVDKEEHMQVVDL 74
+G GF + + T G +VR + A++ G LQ GD +L+I G V QV +
Sbjct: 254 DGSGLGFGI-VGGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQV 312
Query: 75 VRKSGNSVTLLVL---DGD-SYEKAVKTRVDLKELGQSQKEQGLSDNILSPVMNGGVQTW 130
+R GNSV +LV GD S + + + K G SD+ L N
Sbjct: 313 LRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPG-SDSSLFETYN------ 365
Query: 131 TQPRLCYLVKEGGSYGFSLKTVQG------KKGVYMTDITPQGVAMRAG-VLADDHLIEV 183
+ + K+G S G + G G+Y+ I P A G + +D ++ V
Sbjct: 366 ----VELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAV 421
Query: 184 NGENVEDASHEEVVEKVKKSGSRVMFLLVDKET 216
+G N++ ++ +VVE ++ +G V LV ++T
Sbjct: 422 DGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKT 454
Score = 56.2 bits (134), Expect = 7e-08
Identities = 99/480 (20%), Positives = 185/480 (38%), Gaps = 93/480 (19%)
Query: 24 LRIEKDTEGHLVRVVEKCSPAEKAG-LQDGDRVLRINGVFVDKEEHMQVVDLVRKSGNSV 82
L+ ++ +G ++ V + SPA K L+ GD++L ++GV + H + V+ ++ +GN V
Sbjct: 1093 LKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPV 1152
Query: 83 TLLVLDGDS--------YEKAVKTRVDLKELGQSQKEQGLSDNILSPVM----------- 123
+V S + KA K + + Q +KE+ P M
Sbjct: 1153 VFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEK--RQGTAPPPMKLPPPYKALTD 1210
Query: 124 ----NGGVQTWTQPR-------------LCYLVKEGGSYGFSL--KTVQGKKGVYMTDIT 164
N +T + + L K+ G SL + + +++ I
Sbjct: 1211 DSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGIN 1270
Query: 165 PQGVAMRAG-VLADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLVDKETDKRHVEQ 223
P+G A G + D L+E+N + + SH+ +K + S+V + + E D +
Sbjct: 1271 PEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNE-DAVNQMA 1329
Query: 224 KIQFKRETASLKLLPHQPRIVEMKKGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEAGLK 283
F ++S P +E + G+ SE+ G + E G+K
Sbjct: 1330 VTPFPVPSSS-------PSSIEDQSGTE------PISSEEDGSV-----------EVGIK 1365
Query: 284 NNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQE 343
+ E+ V +++ T + +E +P Y S +
Sbjct: 1366 ----------QLPESESFKLAVSQMKQQKYPTKVSFSSQEIP-------LAPASSYHSTD 1408
Query: 344 LPNGSVKEAPAPTPTSLEVSSPPDTTEEVDHKPKLCRLAKGENGYGFHLNAIRGLP--GS 401
AP +S P T V + + ++KG +G G + + P
Sbjct: 1409 ADFTGYGGFQAP------LSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLNAI 1462
Query: 402 FIKEVQKGGPADLAG-LEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTLLVCGKKAY 460
I EV + G A G L D I+EVNGV++ + +E+ + ++ + + V L+V +A+
Sbjct: 1463 VIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDEAH 1522
Score = 48.1 bits (113), Expect = 2e-05
Identities = 63/265 (23%), Positives = 103/265 (38%), Gaps = 37/265 (13%)
Query: 257 LRAGSEQKGQIIKDIDSGSPAEEA-GLKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQT 315
L+ G E KG IK + SPA + LK D ++ V+G ++ H VE I+ G+
Sbjct: 1093 LKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPV 1152
Query: 316 -----SLLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVK-EAPAPTPTSL-----EVSS 364
SL + N++ A + Q+Q+ K + AP P L ++
Sbjct: 1153 VFIVQSLSSTPRVIPNVHNKA--NKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTD 1210
Query: 365 PPDTTEEVD---------------HKPKLCRLAKGENGYGFHL--NAIRGLPGSFIKEVQ 407
D EE D + + L K +NG G L N R F+ +
Sbjct: 1211 DSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGIN 1270
Query: 408 KGGPADLAG-LEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTLL-VCGKKAYDYFQA 465
GPA G + D ++E+N + ++ I+++ V L+ + + A +
Sbjct: 1271 PEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAV 1330
Query: 466 KKIPI----VSSLADPLDTPPDSKE 486
P+ SS+ D T P S E
Sbjct: 1331 TPFPVPSSSPSSIEDQSGTEPISSE 1355
Score = 40.8 bits (94), Expect = 0.003
Identities = 50/226 (22%), Positives = 93/226 (41%), Gaps = 27/226 (11%)
Query: 12 LSKQEGQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAG-LQDGDRVLRINGVFVDKEEHMQ 70
L K+ G+ G + +++ G + + K A+ G L GD++L +NG +
Sbjct: 1536 LQKKAGRGLGLSIVGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQET 1595
Query: 71 VVDLVRKSGNSVTLLV--LDGDSYEKAVKTRVDLKELGQSQKEQGLSDNILSPVMNG--- 125
V +++ + V L + L S+ A T + + G Q +PV+ G
Sbjct: 1596 VATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQ--GSQQSAHSSCHPSFAPVITGLQN 1653
Query: 126 -------------GVQTWTQPRLCYLVKE-GGSYGFSLKTVQGKK----GVYMTDITPQG 167
T +PR + +E + G S+ +G V++ I G
Sbjct: 1654 LVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASG 1713
Query: 168 VAMRAGVL-ADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLV 212
VA R L D ++ +NG+ ++ SH +VV +K + R++ +V
Sbjct: 1714 VAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVV 1759
Score = 37.4 bits (85), Expect = 0.033
Identities = 31/111 (27%), Positives = 52/111 (46%), Gaps = 15/111 (13%)
Query: 398 LPGSFIKEVQKGGPADLAG-LEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTLLVCG 456
L G FIK+V + PA L+ D I+EV+GV++ + + + V+ I+++G V +V
Sbjct: 1099 LKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQS 1158
Query: 457 KKAYDYFQAKKIPIVSSLADPLDTPPDSKEGIVVESNHDSHMAKERAHSTA 507
+ + IP V + A+ I N D+ KE+ TA
Sbjct: 1159 LSS----TPRVIPNVHNKANK----------ITGNQNQDTQEKKEKRQGTA 1195
Score = 36.2 bits (82), Expect = 0.074
Identities = 26/99 (26%), Positives = 47/99 (47%), Gaps = 3/99 (3%)
Query: 402 FIKEVQKGGPADLAGL-EDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTLLVCGKKAY 460
+I + GGP D GL + ED ++EVNG+ + + + V ++ T LVC ++ +
Sbjct: 582 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFT-LVCCRRLF 640
Query: 461 DYFQAKKIPIVSSLADPLDTPPDSKEGIVVESNHDSHMA 499
D + P + + P +T D + E + D +A
Sbjct: 641 DDEASVDEPRRTETSLP-ETEVDHNMDVNTEEDDDGELA 678
Score = 29.3 bits (64), Expect = 9.1
Identities = 17/58 (29%), Positives = 32/58 (55%), Gaps = 1/58 (1%)
Query: 49 LQDGDRVLRINGVFVDKEEHMQVVDLVRKSGNSVTLLVLDGDSYEKAVKTRVDLKELG 106
L+ GDR++ ING +D H VV+L++ + + L V+ D+ A+ +++ G
Sbjct: 1721 LKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVV-ADTNISAIAAQLENMSTG 1777
>gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo
sapiens]
Length = 1287
Score = 65.5 bits (158), Expect = 1e-10
Identities = 61/211 (28%), Positives = 100/211 (47%), Gaps = 29/211 (13%)
Query: 138 LVKEGGSYGFS----LKTVQGKKGVYMTDITPQGVAMRAG-VLADDHLIEVNGENVEDAS 192
LVKE G+ GFS + T G+Y+ I P G A + G +L D L++V+G + +
Sbjct: 931 LVKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLT 990
Query: 193 HEEVVEKVKKSGSRVMFLL---VDKETDK-RHVEQKIQFKRETASL-KLLPHQPRI---- 243
H++ V+ + G +L V + T + + +R SL LP +P
Sbjct: 991 HKQAVQCLTGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSCVSV 1050
Query: 244 -------VEMKKGSNGYGF-YLRAGSEQKGQI------IKDIDSGSPAEEAG-LKNNDLV 288
V++KK +NG GF +++ E + IK + G PAEE G + D++
Sbjct: 1051 TDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDII 1110
Query: 289 VAVNGESVETLDHDSVVEMIRKGGDQTSLLV 319
+AVNG S E L V+ ++R + +LL+
Sbjct: 1111 LAVNGRSTEGLIFQEVLHLLRGAPQEVTLLL 1141
Score = 49.3 bits (116), Expect = 8e-06
Identities = 57/228 (25%), Positives = 95/228 (41%), Gaps = 30/228 (13%)
Query: 244 VEMKKGSNGYGFYLRAGSEQK----GQIIKDIDSGSPAEEAG-LKNNDLVVAVNGESVET 298
VE+ K GF + G G +K I G PA + G + D ++ V+G +
Sbjct: 929 VELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCG 988
Query: 299 LDHDSVVEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVKEAPAPTPT 358
L H V+ + G Q + LV+++ +Q+ P+ + T
Sbjct: 989 LTHKQAVQCLT-GPGQVARLVLERRVPR-------------STQQCPSANDSMGDERTAV 1034
Query: 359 SLEVSSP--PDTTEEVDHKPKL-CRLAKGENGYGFHLNAIRGLPGSF-------IKEVQK 408
SL + P P + V PK +L K NG GF + S IK +
Sbjct: 1035 SLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFP 1094
Query: 409 GGPADLAG-LEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTLLVC 455
G PA+ G + D+I+ VNG + +++V+ ++ + + VTLL+C
Sbjct: 1095 GQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLC 1142
Score = 33.5 bits (75), Expect = 0.48
Identities = 22/77 (28%), Positives = 40/77 (51%), Gaps = 5/77 (6%)
Query: 387 GYGFHLN----AIRGLPGSFIKEVQKGGPADLA-GLEDEDVIIEVNGVNVLDEPYEKVVD 441
G+GF +N + + PG FI + GGPA+ A ++ I+ +N +++ + V
Sbjct: 763 GFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVR 822
Query: 442 RIQSSGKNVTLLVCGKK 458
IQ+S N+ L++ K
Sbjct: 823 MIQNSPDNIELIISQSK 839
Score = 32.3 bits (72), Expect = 1.1
Identities = 44/200 (22%), Positives = 80/200 (40%), Gaps = 32/200 (16%)
Query: 32 GHLVRVVEKCSPAEKAG-LQDGDRVLRINGVFVDKEEHMQVVDLVRKSGNSVTLLVLDGD 90
G V+ + PA K G + GDR+L+++GV + H Q V + G V LVL+
Sbjct: 954 GIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPG-QVARLVLE-- 1010
Query: 91 SYEKAVKTRVDLKELGQSQKEQGLSDNILSPVMNGGVQTWTQPRLCYLVKEGGSYGFSLK 150
+ ++ S ++ + ++++ + +P C V +G + LK
Sbjct: 1011 --RRVPRSTQQCPSANDSMGDERTAVSLVTALPG-------RPSSCVSVTDGPKFEVKLK 1061
Query: 151 T---------VQGKKG---------VYMTDITP-QGVAMRAGVLADDHLIEVNGENVEDA 191
VQ +K V + + P Q + A D ++ VNG + E
Sbjct: 1062 KNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGL 1121
Query: 192 SHEEVVEKVKKSGSRVMFLL 211
+EV+ ++ + V LL
Sbjct: 1122 IFQEVLHLLRGAPQEVTLLL 1141
>gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo
sapiens]
Length = 1309
Score = 65.5 bits (158), Expect = 1e-10
Identities = 61/211 (28%), Positives = 100/211 (47%), Gaps = 29/211 (13%)
Query: 138 LVKEGGSYGFS----LKTVQGKKGVYMTDITPQGVAMRAG-VLADDHLIEVNGENVEDAS 192
LVKE G+ GFS + T G+Y+ I P G A + G +L D L++V+G + +
Sbjct: 953 LVKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLT 1012
Query: 193 HEEVVEKVKKSGSRVMFLL---VDKETDK-RHVEQKIQFKRETASL-KLLPHQPRI---- 243
H++ V+ + G +L V + T + + +R SL LP +P
Sbjct: 1013 HKQAVQCLTGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSCVSV 1072
Query: 244 -------VEMKKGSNGYGF-YLRAGSEQKGQI------IKDIDSGSPAEEAG-LKNNDLV 288
V++KK +NG GF +++ E + IK + G PAEE G + D++
Sbjct: 1073 TDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDII 1132
Query: 289 VAVNGESVETLDHDSVVEMIRKGGDQTSLLV 319
+AVNG S E L V+ ++R + +LL+
Sbjct: 1133 LAVNGRSTEGLIFQEVLHLLRGAPQEVTLLL 1163
Score = 49.3 bits (116), Expect = 8e-06
Identities = 57/228 (25%), Positives = 95/228 (41%), Gaps = 30/228 (13%)
Query: 244 VEMKKGSNGYGFYLRAGSEQK----GQIIKDIDSGSPAEEAG-LKNNDLVVAVNGESVET 298
VE+ K GF + G G +K I G PA + G + D ++ V+G +
Sbjct: 951 VELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCG 1010
Query: 299 LDHDSVVEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVKEAPAPTPT 358
L H V+ + G Q + LV+++ +Q+ P+ + T
Sbjct: 1011 LTHKQAVQCLT-GPGQVARLVLERRVPR-------------STQQCPSANDSMGDERTAV 1056
Query: 359 SLEVSSP--PDTTEEVDHKPKL-CRLAKGENGYGFHLNAIRGLPGSF-------IKEVQK 408
SL + P P + V PK +L K NG GF + S IK +
Sbjct: 1057 SLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFP 1116
Query: 409 GGPADLAG-LEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTLLVC 455
G PA+ G + D+I+ VNG + +++V+ ++ + + VTLL+C
Sbjct: 1117 GQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLC 1164
Score = 33.5 bits (75), Expect = 0.48
Identities = 22/77 (28%), Positives = 40/77 (51%), Gaps = 5/77 (6%)
Query: 387 GYGFHLN----AIRGLPGSFIKEVQKGGPADLA-GLEDEDVIIEVNGVNVLDEPYEKVVD 441
G+GF +N + + PG FI + GGPA+ A ++ I+ +N +++ + V
Sbjct: 785 GFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVR 844
Query: 442 RIQSSGKNVTLLVCGKK 458
IQ+S N+ L++ K
Sbjct: 845 MIQNSPDNIELIISQSK 861
Score = 32.3 bits (72), Expect = 1.1
Identities = 44/200 (22%), Positives = 80/200 (40%), Gaps = 32/200 (16%)
Query: 32 GHLVRVVEKCSPAEKAG-LQDGDRVLRINGVFVDKEEHMQVVDLVRKSGNSVTLLVLDGD 90
G V+ + PA K G + GDR+L+++GV + H Q V + G V LVL+
Sbjct: 976 GIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPG-QVARLVLE-- 1032
Query: 91 SYEKAVKTRVDLKELGQSQKEQGLSDNILSPVMNGGVQTWTQPRLCYLVKEGGSYGFSLK 150
+ ++ S ++ + ++++ + +P C V +G + LK
Sbjct: 1033 --RRVPRSTQQCPSANDSMGDERTAVSLVTALPG-------RPSSCVSVTDGPKFEVKLK 1083
Query: 151 T---------VQGKKG---------VYMTDITP-QGVAMRAGVLADDHLIEVNGENVEDA 191
VQ +K V + + P Q + A D ++ VNG + E
Sbjct: 1084 KNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGL 1143
Query: 192 SHEEVVEKVKKSGSRVMFLL 211
+EV+ ++ + V LL
Sbjct: 1144 IFQEVLHLLRGAPQEVTLLL 1163
>gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]
Length = 1356
Score = 64.7 bits (156), Expect = 2e-10
Identities = 65/224 (29%), Positives = 108/224 (48%), Gaps = 30/224 (13%)
Query: 117 NILSPVMNGGVQTWT-QPRLCYLVKEGGS-YGFSLK----TVQGKKGVYMTDITPQGVAM 170
N+ S ++ G T RL +K+G GFS+ T+ G +Y+ +I P+G A+
Sbjct: 441 NVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAI 500
Query: 171 RAGVL-ADDHLIEVNGENVEDASHEEVVEKVKKSGSR-VMFLLVDKETDKRHVEQ----- 223
+ G L A D LIEVNG ++ S EEVV ++ + + LLV ++ D H +
Sbjct: 501 QDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEP 560
Query: 224 -KIQFKRETAS----LKLLPHQPR------IVEMKKGSNGYGFYLRAGSEQK-----GQI 267
++Q +ET + + L P R + GS G G ++ ++ G
Sbjct: 561 SQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIF 620
Query: 268 IKDIDSGSPAEEAG-LKNNDLVVAVNGESVETLDHDSVVEMIRK 310
+K I +G A + G L+ ND ++AVNGES+ + +E +R+
Sbjct: 621 VKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRR 664
Score = 46.6 bits (109), Expect = 6e-05
Identities = 62/288 (21%), Positives = 109/288 (37%), Gaps = 65/288 (22%)
Query: 242 RIVEMKKGSNGYGFYL----RAGSEQKGQIIKDIDSGSPAEEAGL-KNNDLVVAVNGESV 296
++VE+ G ++ G G ++K ++ G AE L + ND +V +N +
Sbjct: 273 KLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGDL 332
Query: 297 ETLDHDSVVEMIRKG-------------GDQTSLLVVDKETDNMYRLAHFSPFLYYQSQE 343
+ M R+ ++ + + N Y + FSP SQ
Sbjct: 333 RNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSP----DSQY 388
Query: 344 LPNGSVKEA-----------------------------PAPTPTSLEVSSPPD---TTEE 371
+ N SV A P+ P S S+P + TT
Sbjct: 389 IDNRSVNSAGLHTVQRAPRLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVS 448
Query: 372 VDHKPKLC------RLAKGENGYGFHLNA----IRGLPGSFIKEVQKGGPADLAG-LEDE 420
+ K +L KG G GF + + I G ++K + G A G L+
Sbjct: 449 SGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAG 508
Query: 421 DVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTLLVCGKKAYDYFQAKKI 468
D +IEVNGV+++ + E+VV ++S+ T+ + + D F +++
Sbjct: 509 DRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPREL 556
Score = 46.6 bits (109), Expect = 6e-05
Identities = 51/210 (24%), Positives = 97/210 (46%), Gaps = 25/210 (11%)
Query: 14 KQEGQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDG-----DRVLRINGVFVDKEEH 68
K+ + GF + T G + K A +QDG DR++ +NGV + +
Sbjct: 465 KKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQ 524
Query: 69 MQVVDLVR--KSGNSVTLLVLDGDS--YEKAVKTRVDLKELGQSQKEQGLSDNILSPVMN 124
+VV L+R K +V+LLV + + + + ++ + K + D +L+P
Sbjct: 525 EEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAED-EDIVLTPDGT 583
Query: 125 GGVQTWTQPRLCYLVKEGGSYGFSLKTVQGKK--------GVYMTDITPQGVAMRAGVL- 175
T+ P + + GS G + +V+G + G+++ I G A + G L
Sbjct: 584 REFLTFEVP-----LNDSGSAGLGV-SVKGNRSKENHADLGIFVKSIINGGAASKDGRLR 637
Query: 176 ADDHLIEVNGENVEDASHEEVVEKVKKSGS 205
+D LI VNGE++ ++++ +E +++S S
Sbjct: 638 VNDQLIAVNGESLLGKTNQDAMETLRRSMS 667
>gi|119120907 par-3 partitioning defective 3 homolog B isoform a
[Homo sapiens]
Length = 1104
Score = 64.3 bits (155), Expect = 3e-10
Identities = 81/353 (22%), Positives = 151/353 (42%), Gaps = 64/353 (18%)
Query: 22 FFLRIEKDTEGHLVRVVEKCSPAEKAGL-QDGDRVLRINGVFVDKEEHMQVVDLVRKSGN 80
FF + G +R +E S +++ GL + + +++IN V + + Q D+ R++
Sbjct: 220 FFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMK 279
Query: 81 SVTLLV-----LDGDSYEKAV--------------KTRVDLKELGQS------------- 108
S ++L+ + + YEK+V KT+V G+S
Sbjct: 280 SPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSP 339
Query: 109 ------QKEQGLSDNI-----------LSPVMNGGVQTWTQPRLCYLVKEGGSYGFSLKT 151
+Q S + LSP+M G + L K GF++ T
Sbjct: 340 ETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVT 399
Query: 152 ----VQGKKGVYMTDITPQGVAMRAGVL-ADDHLIEVNGENVEDASHEEVVEKVKKSGSR 206
+ G +++ +I P+G A++ G L + D ++EVNG +V + EE+V ++ +
Sbjct: 400 RDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQG 459
Query: 207 VMFLLVDKETDKRHVEQKIQFKRETASLKLLPHQPRIVEMK---KGSNGYGFYLRAGSEQ 263
LV + + ++++ + + +L L + E+ GS G G L+ +
Sbjct: 460 ETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSR 519
Query: 264 K-----GQIIKDIDSGSPAEEAG-LKNNDLVVAVNGESVETLDHDSVVEMIRK 310
+ G IK I G A + G L+ ND ++AVNGES+ + +E +R+
Sbjct: 520 ETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRR 572
Score = 49.3 bits (116), Expect = 8e-06
Identities = 54/219 (24%), Positives = 98/219 (44%), Gaps = 34/219 (15%)
Query: 3 STFNPRECKLSKQEGQNYGFFLRIEKDTEGH------LVRVVEKCSPAEKAGLQDGDRVL 56
S N ++ K+ ++G F + +D+ H + ++ K + + LQ GDR+L
Sbjct: 375 SNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRIL 434
Query: 57 RINGVFVDKEEHMQVVDLVR--KSGNSVTLLVL--DGDSYEKAVKTRVDLKELGQSQKEQ 112
+NG V ++V ++R K G + +L++ +G + +K D L EQ
Sbjct: 435 EVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQ 494
Query: 113 GLSDNILSPVMNGGVQTWTQPRLCYLVKEGGSYGFSLKTVQGKK-----GVYMTDITPQG 167
L+ I P+ + G G SLK + ++ G+++ I G
Sbjct: 495 -LTFEI--PLNDSG---------------SAGLGVSLKGNKSRETGTDLGIFIKSIIHGG 536
Query: 168 VAMRAGVL-ADDHLIEVNGENVEDASHEEVVEKVKKSGS 205
A + G L +D LI VNGE++ S+ E +E +++S S
Sbjct: 537 AAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMS 575
Score = 34.7 bits (78), Expect = 0.22
Identities = 26/87 (29%), Positives = 46/87 (52%), Gaps = 7/87 (8%)
Query: 381 LAKGENGYGFHL----NAIRGLPGSFIKEVQKGGPADLAG-LEDEDVIIEVNGVNVLDEP 435
L KG G GF + ++I G F+K + G A G L+ D I+EVNG +V
Sbjct: 386 LKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRT 445
Query: 436 YEKVVDRIQSS--GKNVTLLVCGKKAY 460
E++V ++S+ G+ +L++ ++ +
Sbjct: 446 QEELVAMLRSTKQGETASLVIARQEGH 472
>gi|119120903 par-3 partitioning defective 3 homolog B isoform c
[Homo sapiens]
Length = 1136
Score = 64.3 bits (155), Expect = 3e-10
Identities = 81/353 (22%), Positives = 151/353 (42%), Gaps = 64/353 (18%)
Query: 22 FFLRIEKDTEGHLVRVVEKCSPAEKAGL-QDGDRVLRINGVFVDKEEHMQVVDLVRKSGN 80
FF + G +R +E S +++ GL + + +++IN V + + Q D+ R++
Sbjct: 220 FFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMK 279
Query: 81 SVTLLV-----LDGDSYEKAV--------------KTRVDLKELGQS------------- 108
S ++L+ + + YEK+V KT+V G+S
Sbjct: 280 SPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSP 339
Query: 109 ------QKEQGLSDNI-----------LSPVMNGGVQTWTQPRLCYLVKEGGSYGFSLKT 151
+Q S + LSP+M G + L K GF++ T
Sbjct: 340 ETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVT 399
Query: 152 ----VQGKKGVYMTDITPQGVAMRAGVL-ADDHLIEVNGENVEDASHEEVVEKVKKSGSR 206
+ G +++ +I P+G A++ G L + D ++EVNG +V + EE+V ++ +
Sbjct: 400 RDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQG 459
Query: 207 VMFLLVDKETDKRHVEQKIQFKRETASLKLLPHQPRIVEMK---KGSNGYGFYLRAGSEQ 263
LV + + ++++ + + +L L + E+ GS G G L+ +
Sbjct: 460 ETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSR 519
Query: 264 K-----GQIIKDIDSGSPAEEAG-LKNNDLVVAVNGESVETLDHDSVVEMIRK 310
+ G IK I G A + G L+ ND ++AVNGES+ + +E +R+
Sbjct: 520 ETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRR 572
Score = 49.3 bits (116), Expect = 8e-06
Identities = 54/219 (24%), Positives = 98/219 (44%), Gaps = 34/219 (15%)
Query: 3 STFNPRECKLSKQEGQNYGFFLRIEKDTEGH------LVRVVEKCSPAEKAGLQDGDRVL 56
S N ++ K+ ++G F + +D+ H + ++ K + + LQ GDR+L
Sbjct: 375 SNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRIL 434
Query: 57 RINGVFVDKEEHMQVVDLVR--KSGNSVTLLVL--DGDSYEKAVKTRVDLKELGQSQKEQ 112
+NG V ++V ++R K G + +L++ +G + +K D L EQ
Sbjct: 435 EVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQ 494
Query: 113 GLSDNILSPVMNGGVQTWTQPRLCYLVKEGGSYGFSLKTVQGKK-----GVYMTDITPQG 167
L+ I P+ + G G SLK + ++ G+++ I G
Sbjct: 495 -LTFEI--PLNDSG---------------SAGLGVSLKGNKSRETGTDLGIFIKSIIHGG 536
Query: 168 VAMRAGVL-ADDHLIEVNGENVEDASHEEVVEKVKKSGS 205
A + G L +D LI VNGE++ S+ E +E +++S S
Sbjct: 537 AAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMS 575
Score = 34.7 bits (78), Expect = 0.22
Identities = 26/87 (29%), Positives = 46/87 (52%), Gaps = 7/87 (8%)
Query: 381 LAKGENGYGFHL----NAIRGLPGSFIKEVQKGGPADLAG-LEDEDVIIEVNGVNVLDEP 435
L KG G GF + ++I G F+K + G A G L+ D I+EVNG +V
Sbjct: 386 LKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRT 445
Query: 436 YEKVVDRIQSS--GKNVTLLVCGKKAY 460
E++V ++S+ G+ +L++ ++ +
Sbjct: 446 QEELVAMLRSTKQGETASLVIARQEGH 472
>gi|148727255 microtubule associated serine/threonine kinase family
member 4 isoform a [Homo sapiens]
Length = 2434
Score = 62.0 bits (149), Expect = 1e-09
Identities = 36/107 (33%), Positives = 58/107 (54%), Gaps = 10/107 (9%)
Query: 229 RETASLKLLPHQPRIVEMKKGSNGYGFYLRAGSEQKGQ--------IIKDIDSGSPAEEA 280
R++++ PHQP ++ G N YGF +RA G I+ +++ GSPA +A
Sbjct: 940 RDSSAASASPHQPIVIH-SSGKN-YGFTIRAIRVYVGDSDIYTVHHIVWNVEEGSPACQA 997
Query: 281 GLKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLVVDKETDNM 327
GLK DL+ +NGE V L H V+E++ K G++ S+ E ++
Sbjct: 998 GLKAGDLITHINGEPVHGLVHTEVIELLLKSGNKVSITTTPFENTSI 1044
Score = 52.8 bits (125), Expect = 8e-07
Identities = 38/125 (30%), Positives = 66/125 (52%), Gaps = 17/125 (13%)
Query: 6 NPRECKLSKQEGQNYGFFLRIEKDTEG--------HLVRVVEKCSPAEKAGLQDGDRVLR 57
+P + + G+NYGF +R + G H+V VE+ SPA +AGL+ GD +
Sbjct: 948 SPHQPIVIHSSGKNYGFTIRAIRVYVGDSDIYTVHHIVWNVEEGSPACQAGLKAGDLITH 1007
Query: 58 INGVFVDKEEHMQVVDLVRKSGNSVTLL--------VLDGDSYEKAVKTRVDLKELGQSQ 109
ING V H +V++L+ KSGN V++ + G + + K+R+ ++ +S+
Sbjct: 1008 INGEPVHGLVHTEVIELLLKSGNKVSITTTPFENTSIKTGPARRNSYKSRM-VRRSKKSK 1066
Query: 110 KEQGL 114
K++ L
Sbjct: 1067 KKESL 1071
Score = 41.2 bits (95), Expect = 0.002
Identities = 23/74 (31%), Positives = 40/74 (54%), Gaps = 8/74 (10%)
Query: 142 GGSYGFSLKTVQ---GKKGVYMT-----DITPQGVAMRAGVLADDHLIEVNGENVEDASH 193
G +YGF+++ ++ G +Y ++ A +AG+ A D + +NGE V H
Sbjct: 959 GKNYGFTIRAIRVYVGDSDIYTVHHIVWNVEEGSPACQAGLKAGDLITHINGEPVHGLVH 1018
Query: 194 EEVVEKVKKSGSRV 207
EV+E + KSG++V
Sbjct: 1019 TEVIELLLKSGNKV 1032
Score = 40.0 bits (92), Expect = 0.005
Identities = 32/107 (29%), Positives = 52/107 (48%), Gaps = 13/107 (12%)
Query: 357 PTSLEVSSPPDTTEEVD---HKPKLCRLAKGENGYGFHLNAIRGLPGS--------FIKE 405
P+S SSP + H+P + + G+N YGF + AIR G +
Sbjct: 930 PSSSRDSSPSRDSSAASASPHQPIVIH-SSGKN-YGFTIRAIRVYVGDSDIYTVHHIVWN 987
Query: 406 VQKGGPADLAGLEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTL 452
V++G PA AGL+ D+I +NG V + +V++ + SG V++
Sbjct: 988 VEEGSPACQAGLKAGDLITHINGEPVHGLVHTEVIELLLKSGNKVSI 1034
>gi|13376349 PDZ domain containing 7 [Homo sapiens]
Length = 517
Score = 61.6 bits (148), Expect = 2e-09
Identities = 67/252 (26%), Positives = 109/252 (43%), Gaps = 38/252 (15%)
Query: 134 RLCYLVKEGGSYGFSLKTVQGKKGVYMTDITPQGVAMRAGVLADDHLIEVNGENVEDASH 193
RL + V+ G +G G++++ + A RAG+ D + EVNG ++E +
Sbjct: 96 RLGFSVRGGSEHGL---------GIFVSKVEEGSSAERAGLCVGDKITEVNGLSLESTTM 146
Query: 194 EEVVEKVKKSGSRVMFLL------------------VDKETDKRHVEQKIQFKRETASLK 235
V KV S SR+ ++ VD + VE+ +T+S
Sbjct: 147 GSAV-KVLTSSSRLHMMVRRMGRVPGIKFSKEKTTWVDVVNRRLVVEKCGSTPSDTSSED 205
Query: 236 LLPHQPRIVEMKKGSNGY--GFYLRAGSE-QKGQIIKDIDSGSPAEEAGLKNNDLVVAVN 292
+ RIV + S+ + GF +R G E G + +D G AEE G+K D V+A N
Sbjct: 206 GVR---RIVHLYTTSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAEENGIKVGDQVLAAN 262
Query: 293 GESVETLDHDSVVEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVKEA 352
G + + H VE+++ QT +++ KET Y Y L NG +++
Sbjct: 263 GVRFDDISHSQAVEVLK---GQTHIMLTIKET-GRYPAYKEMVSEYCWLDRLSNGVLQQL 318
Query: 353 PAPTPTSLEVSS 364
+ +S VSS
Sbjct: 319 SPASESSSSVSS 330
Score = 51.2 bits (121), Expect = 2e-06
Identities = 47/194 (24%), Positives = 85/194 (43%), Gaps = 17/194 (8%)
Query: 32 GHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDLVRKSGNSVTLL----VL 87
G V VE+ S AE+AGL GD++ +NG+ ++ V ++ S ++ +
Sbjct: 110 GIFVSKVEEGSSAERAGLCVGDKITEVNGLSLESTTMGSAVKVLTSSSRLHMMVRRMGRV 169
Query: 88 DGDSYEKAVKTRVDLKELGQSQKEQGLSDNILSPVMNGGVQTWTQPRLCYLVKEGGSYGF 147
G + K T VD+ ++ G + + S GV+ R+ +L +
Sbjct: 170 PGIKFSKEKTTWVDVVNRRLVVEKCGSTPSDTS--SEDGVR-----RIVHLYTTSDDFCL 222
Query: 148 SLKTVQGKK---GVYMTDITPQGVAMRAGVLADDHLIEVNGENVEDASHEEVVEKVKKSG 204
GK+ G+Y++ + G+A G+ D ++ NG +D SH + VE +K
Sbjct: 223 GFNIRGGKEFGLGIYVSKVDHGGLAEENGIKVGDQVLAANGVRFDDISHSQAVEVLK--- 279
Query: 205 SRVMFLLVDKETDK 218
+ +L KET +
Sbjct: 280 GQTHIMLTIKETGR 293
Score = 45.8 bits (107), Expect = 9e-05
Identities = 51/200 (25%), Positives = 85/200 (42%), Gaps = 19/200 (9%)
Query: 247 KKGSNGYGFYLRAGSEQK-GQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVETLDHDSVV 305
K + GF +R GSE G + ++ GS AE AGL D + VNG S+E+ S V
Sbjct: 91 KSPAGRLGFSVRGGSEHGLGIFVSKVEEGSSAERAGLCVGDKITEVNGLSLESTTMGSAV 150
Query: 306 EMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVKEAPAPTPTSLEVSSP 365
++ L M R P + + ++ V S+P
Sbjct: 151 KV----------LTSSSRLHMMVRRMGRVPGIKFSKEKTTWVDVVNRRLVVEKC--GSTP 198
Query: 366 PDTTEEVDHKPKLCRLAKGENGY--GFHLNAIR--GLPGSFIKEVQKGGPADLAGLEDED 421
DT+ E D ++ L + + GF++ + GL G ++ +V GG A+ G++ D
Sbjct: 199 SDTSSE-DGVRRIVHLYTTSDDFCLGFNIRGGKEFGL-GIYVSKVDHGGLAEENGIKVGD 256
Query: 422 VIIEVNGVNVLDEPYEKVVD 441
++ NGV D + + V+
Sbjct: 257 QVLAANGVRFDDISHSQAVE 276
Score = 39.3 bits (90), Expect = 0.009
Identities = 31/118 (26%), Positives = 56/118 (47%), Gaps = 6/118 (5%)
Query: 336 FLYYQSQELPNGSVKEAPAPTPTS--LEVSSPPDTTEE---VDHKPKLCRLAKGENGYGF 390
+L + Q L NG + A +P + ++SP + + + H ++ + G G+
Sbjct: 42 YLLRKQQRLLNGPPRGIRASSPMGRVILINSPIEANSDESDIIHSVRVEKSPAGRLGFSV 101
Query: 391 HLNAIRGLPGSFIKEVQKGGPADLAGLEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGK 448
+ GL G F+ +V++G A+ AGL D I EVNG+++ V + SS +
Sbjct: 102 RGGSEHGL-GIFVSKVEEGSSAERAGLCVGDKITEVNGLSLESTTMGSAVKVLTSSSR 158
Score = 33.1 bits (74), Expect = 0.63
Identities = 19/60 (31%), Positives = 31/60 (51%), Gaps = 9/60 (15%)
Query: 17 GQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDLVR 76
G+ +G + + K G L AE+ G++ GD+VL NGV D H Q V++++
Sbjct: 229 GKEFGLGIYVSKVDHGGL---------AEENGIKVGDQVLAANGVRFDDISHSQAVEVLK 279
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.132 0.369
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,559,586
Number of Sequences: 37866
Number of extensions: 980766
Number of successful extensions: 3590
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 149
Number of HSP's successfully gapped in prelim test: 57
Number of HSP's that attempted gapping in prelim test: 2610
Number of HSP's gapped (non-prelim): 858
length of query: 519
length of database: 18,247,518
effective HSP length: 107
effective length of query: 412
effective length of database: 14,195,856
effective search space: 5848692672
effective search space used: 5848692672
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.