Guide to the Human Genome
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Search of human proteins with 205277471

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|205277471 cochlin precursor [Homo sapiens]
         (550 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|205277471 cochlin precursor [Homo sapiens]                        1104   0.0  
gi|4758022 cochlin precursor [Homo sapiens]                          1104   0.0  
gi|21359974 vitrin [Homo sapiens]                                     375   e-104
gi|4505111 matrilin 1, cartilage matrix protein [Homo sapiens]        160   4e-39
gi|156616290 collagen type VI alpha 6 [Homo sapiens]                  155   7e-38
gi|55743098 alpha 3 type VI collagen isoform 1 precursor [Homo s...   154   3e-37
gi|183583553 collagen, type XXIX, alpha 1 [Homo sapiens]              147   2e-35
gi|13699836 matrilin 4 isoform 3 precursor [Homo sapiens]             145   7e-35
gi|55743106 alpha 3 type VI collagen isoform 5 precursor [Homo s...   140   4e-33
gi|240255540 alpha 3 type VI collagen isoform 3 precursor [Homo ...   140   4e-33
gi|240255542 alpha 3 type VI collagen isoform 2 precursor [Homo ...   138   1e-32
gi|93141047 collagen, type XII, alpha 1 long isoform precursor [...   132   8e-31
gi|240255535 alpha 3 type VI collagen isoform 4 precursor [Homo ...   129   5e-30
gi|40805823 collagen, type XXII, alpha 1 [Homo sapiens]               120   3e-27
gi|55743096 collagen, type XIV, alpha 1 [Homo sapiens]                119   9e-27
gi|93141049 collagen, type XII, alpha 1 short isoform precursor ...   117   3e-26
gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]             108   1e-23
gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]             108   1e-23
gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens]         105   8e-23
gi|18780273 collagen, type XXI, alpha 1 precursor [Homo sapiens]      104   2e-22
gi|112734845 collagen, type XX, alpha 1 [Homo sapiens]                104   2e-22
gi|89191868 von Willebrand factor preproprotein [Homo sapiens]        103   4e-22
gi|13699834 matrilin 4 isoform 2 precursor [Homo sapiens]             103   5e-22
gi|13699830 matrilin 4 isoform 1 precursor [Homo sapiens]             103   5e-22
gi|38348304 von Willebrand factor A domain containing 2 [Homo sa...    95   2e-19
gi|11321565 matrilin 3 precursor [Homo sapiens]                        89   8e-18
gi|40068485 von Willebrand factor A domain containing 1 isoform ...    79   8e-15
gi|34452173 integrin alpha X precursor [Homo sapiens]                  79   1e-14
gi|148886654 polydom [Homo sapiens]                                    76   7e-14
gi|224831239 integrin alpha M isoform 1 precursor [Homo sapiens]       76   9e-14

>gi|205277471 cochlin precursor [Homo sapiens]
          Length = 550

 Score = 1104 bits (2855), Expect = 0.0
 Identities = 550/550 (100%), Positives = 550/550 (100%)

Query: 1   MSAAWIPALGLGVCLLLLPGPAGSEGAAPIAITCFTRGLDIRKEKADVLCPGGCPLEEFS 60
           MSAAWIPALGLGVCLLLLPGPAGSEGAAPIAITCFTRGLDIRKEKADVLCPGGCPLEEFS
Sbjct: 1   MSAAWIPALGLGVCLLLLPGPAGSEGAAPIAITCFTRGLDIRKEKADVLCPGGCPLEEFS 60

Query: 61  VYGNIVYASVSSICGAAVHRGVISNSGGPVRVYSLPGRENYSSVDANGIQSQMLSRWSAS 120
           VYGNIVYASVSSICGAAVHRGVISNSGGPVRVYSLPGRENYSSVDANGIQSQMLSRWSAS
Sbjct: 61  VYGNIVYASVSSICGAAVHRGVISNSGGPVRVYSLPGRENYSSVDANGIQSQMLSRWSAS 120

Query: 121 FTVTKGKSSTQEATGQAVSTAHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRR 180
           FTVTKGKSSTQEATGQAVSTAHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRR
Sbjct: 121 FTVTKGKSSTQEATGQAVSTAHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRR 180

Query: 181 FNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGG 240
           FNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGG
Sbjct: 181 FNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGG 240

Query: 241 NSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVS 300
           NSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVS
Sbjct: 241 NSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVS 300

Query: 301 VAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSK 360
           VAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSK
Sbjct: 301 VAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSK 360

Query: 361 TCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFS 420
           TCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFS
Sbjct: 361 TCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFS 420

Query: 421 FTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRESPNKNFLVIVTDGQSYD 480
           FTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRESPNKNFLVIVTDGQSYD
Sbjct: 421 FTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRESPNKNFLVIVTDGQSYD 480

Query: 481 DVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRG 540
           DVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRG
Sbjct: 481 DVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRG 540

Query: 541 ICRDFLESQQ 550
           ICRDFLESQQ
Sbjct: 541 ICRDFLESQQ 550


>gi|4758022 cochlin precursor [Homo sapiens]
          Length = 550

 Score = 1104 bits (2855), Expect = 0.0
 Identities = 550/550 (100%), Positives = 550/550 (100%)

Query: 1   MSAAWIPALGLGVCLLLLPGPAGSEGAAPIAITCFTRGLDIRKEKADVLCPGGCPLEEFS 60
           MSAAWIPALGLGVCLLLLPGPAGSEGAAPIAITCFTRGLDIRKEKADVLCPGGCPLEEFS
Sbjct: 1   MSAAWIPALGLGVCLLLLPGPAGSEGAAPIAITCFTRGLDIRKEKADVLCPGGCPLEEFS 60

Query: 61  VYGNIVYASVSSICGAAVHRGVISNSGGPVRVYSLPGRENYSSVDANGIQSQMLSRWSAS 120
           VYGNIVYASVSSICGAAVHRGVISNSGGPVRVYSLPGRENYSSVDANGIQSQMLSRWSAS
Sbjct: 61  VYGNIVYASVSSICGAAVHRGVISNSGGPVRVYSLPGRENYSSVDANGIQSQMLSRWSAS 120

Query: 121 FTVTKGKSSTQEATGQAVSTAHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRR 180
           FTVTKGKSSTQEATGQAVSTAHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRR
Sbjct: 121 FTVTKGKSSTQEATGQAVSTAHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRR 180

Query: 181 FNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGG 240
           FNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGG
Sbjct: 181 FNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGG 240

Query: 241 NSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVS 300
           NSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVS
Sbjct: 241 NSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVS 300

Query: 301 VAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSK 360
           VAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSK
Sbjct: 301 VAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSK 360

Query: 361 TCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFS 420
           TCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFS
Sbjct: 361 TCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFS 420

Query: 421 FTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRESPNKNFLVIVTDGQSYD 480
           FTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRESPNKNFLVIVTDGQSYD
Sbjct: 421 FTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRESPNKNFLVIVTDGQSYD 480

Query: 481 DVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRG 540
           DVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRG
Sbjct: 481 DVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRG 540

Query: 541 ICRDFLESQQ 550
           ICRDFLESQQ
Sbjct: 541 ICRDFLESQQ 550


>gi|21359974 vitrin [Homo sapiens]
          Length = 693

 Score =  375 bits (964), Expect = e-104
 Identities = 180/389 (46%), Positives = 263/389 (67%), Gaps = 3/389 (0%)

Query: 158 GNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEF 217
           G+ +CK D++FLIDGS +IG+RRF +QK  +  VA  L IG  GP +G+VQ  ++P   F
Sbjct: 301 GDPNCKIDLSFLIDGSTSIGKRRFRIQKQLLADVAQALDIGPAGPLMGVVQYGDNPATHF 360

Query: 218 YLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGW 277
            LK  T+++D+  AI+++  RGG SN G+A+    + FF+   G R G P VVVV +DGW
Sbjct: 361 NLKTHTNSRDLKTAIEKITQRGGLSNVGRAISFVTKNFFSKANGNRSGAPNVVVVMVDGW 420

Query: 278 PSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWF 337
           P+D +EEA  +ARE G+N+F +++      E   V +  F +KAVCR NGF+S H+ +WF
Sbjct: 421 PTDKVEEASRLARESGINIFFITIEGAAENEKQYVVEPNFANKAVCRTNGFYSLHVQSWF 480

Query: 338 GTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTF 397
           G  K ++PLV+++C  +++ CSKTC NS +I F+IDGSSSVG  NFR +L+FV+N+ K F
Sbjct: 481 GLHKTLQPLVKRVCDTDRLACSKTCLNSADIGFVIDGSSSVGTGNFRTVLQFVTNLTKEF 540

Query: 398 EISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNV 457
           EISD   +I AVQ+TY+QR EF F  YS+K ++L  I+ + Y SGGT+TG AI+F +  +
Sbjct: 541 EISDTDTRIGAVQYTYEQRLEFGFDKYSSKPDILNAIKRVGYWSGGTSTGAAINFALEQL 600

Query: 458 FGPIRESPNK-NFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKP 516
           F   +  PNK   ++++TDG+SYDDV+ PA AAH  G+  +++GVAWA  ++L+ +A+ P
Sbjct: 601 FK--KSKPNKRKLMILITDGRSYDDVRIPAMAAHLKGVITYAIGVAWAAQEELEVIATHP 658

Query: 517 KESHAFFTREFTGLEPIVSDVIRGICRDF 545
              H+FF  EF  L   V  +I+ IC +F
Sbjct: 659 ARDHSFFVDEFDNLHQYVPRIIQNICTEF 687



 Score = 85.9 bits (211), Expect = 9e-17
 Identities = 43/96 (44%), Positives = 55/96 (57%)

Query: 32  ITCFTRGLDIRKEKADVLCPGGCPLEEFSVYGNIVYASVSSICGAAVHRGVISNSGGPVR 91
           I C  +   I   +  V CP GC   ++ VYG  VYAS SS+CGAAVH GV+ NSGG + 
Sbjct: 44  INCDVKAGKIIDPEFIVKCPAGCQDPKYHVYGTDVYASYSSVCGAAVHSGVLDNSGGKIL 103

Query: 92  VYSLPGRENYSSVDANGIQSQMLSRWSASFTVTKGK 127
           V  + G+  Y    +NG+QS  L RW  SF V + K
Sbjct: 104 VRKVAGQSGYKGSYSNGVQSLSLPRWRESFIVLESK 139


>gi|4505111 matrilin 1, cartilage matrix protein [Homo sapiens]
          Length = 496

 Score =  160 bits (404), Expect = 4e-39
 Identities = 118/428 (27%), Positives = 189/428 (44%), Gaps = 66/428 (15%)

Query: 165 DIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTS 224
           D+ F++D S ++    F   K F+ +V   L +G     VG+V  +   K EF L+   S
Sbjct: 41  DLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVS 100

Query: 225 AKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIP---KVVVVFIDGWPSDD 281
              +L A++ +      + TG A++    K F    G R   P   KVV+V  DG P D 
Sbjct: 101 KAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDS 160

Query: 282 IEEAGIVAREFGVNVFIVSV------------AKPIPEELGMVQDVTFVDKAVCRNNGFF 329
           +++    AR  GV +F + V            ++P  E +  V+  + ++K   +    F
Sbjct: 161 VQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEAF 220

Query: 330 SYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNS------------------------ 365
                           +V  LC      C + C +S                        
Sbjct: 221 C---------------VVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVC 265

Query: 366 --------VNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRT 417
                    ++ FLIDGS SV   NF L+ +F+S I  T ++SD  A++  VQ++   R 
Sbjct: 266 SGGGGSSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQ 325

Query: 418 EFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVF---GPIRESPNKNFLVIVT 474
           EF    + TK+++ A +RN+ YM  GT TG A+ + + N F      R    K   ++ T
Sbjct: 326 EFPLGRFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQK-VGIVFT 384

Query: 475 DGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIV 534
           DG+S D +   A  A D G  +F+VGV  A  D+L+++AS+P   H F+T +F  +  I 
Sbjct: 385 DGRSQDYINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIG 444

Query: 535 SDVIRGIC 542
             + + IC
Sbjct: 445 KKLQKKIC 452



 Score = 97.1 bits (240), Expect = 4e-20
 Identities = 67/232 (28%), Positives = 107/232 (46%), Gaps = 15/232 (6%)

Query: 91  RVYSLPGRENYSSVDANGIQSQMLSRWSASFTVTKGKSSTQEATGQAVSTAHPPTGKRLK 150
           ++ S P  E+   V++  +  ++  ++  +F V     +T +   + V  + P  G    
Sbjct: 190 QIASEPQDEHVDYVESYSVIEKLSRKFQEAFCVVSDLCATGDHDCEQVCISSP--GSYTC 247

Query: 151 KTPEKKTGNKDCKA-------------DIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGI 197
              E  T N D K              D+ FLIDGS ++    F L K F+ ++   L +
Sbjct: 248 ACHEGFTLNSDGKTCNVCSGGGGSSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDV 307

Query: 198 GTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFT 257
             +   VGLVQ S   + EF L  F + KD+  A++ + +    + TG ALK+     FT
Sbjct: 308 SDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFT 367

Query: 258 VDAGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEEL 309
           V +G R G  KV +VF DG   D I +A   A++ G  +F V V   + +EL
Sbjct: 368 VSSGARPGAQKVGIVFTDGRSQDYINDAAKKAKDLGFKMFAVGVGNAVEDEL 419


>gi|156616290 collagen type VI alpha 6 [Homo sapiens]
          Length = 2263

 Score =  155 bits (393), Expect = 7e-38
 Identities = 112/396 (28%), Positives = 194/396 (48%), Gaps = 22/396 (5%)

Query: 150 KKTPEKKTGNKDCK-ADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQ 208
           ++T   K+G  D + ADI  LIDGS +     F+  K F+ +V  M  I      VG VQ
Sbjct: 420 ERTETLKSGCVDTEEADIYLLIDGSGSTQATDFHEMKTFLSEVVGMFNIAPHKVRVGAVQ 479

Query: 209 ASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPK 268
            ++   +EF +  +++ +D+  AI+ +   GGN+NTG AL  T              +P 
Sbjct: 480 YADSWDLEFEINKYSNKQDLGKAIENIRQMGGNTNTGAALNFTLSLLQKAKKQRGNKVPC 539

Query: 269 VVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGF 328
            +VV  +G   D I E     RE  + V+ + + +    +L   +++   +K V      
Sbjct: 540 HLVVLTNGMSKDSILEPANRLREEHIRVYAIGIKEANQTQL---REIAGEEKRV------ 590

Query: 329 FSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLE 388
             Y++ ++         +VQ++CT E   C +      +I FL+D S S+G  NF  M  
Sbjct: 591 --YYVHDFDALKDIRNQVVQEICTEE--ACKEM---KADIMFLVDSSGSIGPENFSKMKT 643

Query: 389 FVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGD 448
           F+ N+    +I     +I  VQF+   + EF    + ++ ++   I  + ++   T TG 
Sbjct: 644 FMKNLVSKSQIGPDRVQIGVVQFSDINKEEFQLNRFMSQSDISNAIDQMAHIGQTTLTGS 703

Query: 449 AISFTVRNVFGPIRES-PN-KNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPL 506
           A+SF V   F P + + PN + FL+++TDG++ D V+ PA      G+ I+SVGV  + +
Sbjct: 704 ALSF-VSQYFSPTKGARPNIRKFLILITDGEAQDIVKEPAVVLRQEGVIIYSVGVFGSNV 762

Query: 507 DDLKDMASKPKESHAFFTREFTGLEPIVSDVIRGIC 542
             L++++ +P+    F+   F  L+ I  D++ GIC
Sbjct: 763 TQLEEISGRPE--MVFYVENFDILQRIEDDLVFGIC 796



 Score =  153 bits (387), Expect = 3e-37
 Identities = 114/389 (29%), Positives = 191/389 (49%), Gaps = 24/389 (6%)

Query: 160 KDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYL 219
           K+ KADI FL+D S +IG   F+  K F+  +     IG +   +G+VQ S+  K EF L
Sbjct: 617 KEMKADIMFLVDSSGSIGPENFSKMKTFMKNLVSKSQIGPDRVQIGVVQFSDINKEEFQL 676

Query: 220 KNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPS 279
             F S  D+  AI ++   G  + TG AL   +Q +F+   G R  I K +++  DG   
Sbjct: 677 NRFMSQSDISNAIDQMAHIGQTTLTGSALSFVSQ-YFSPTKGARPNIRKFLILITDGEAQ 735

Query: 280 DDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGT 339
           D ++E  +V R+ GV ++ V V            +VT +++   R    F  ++ N+   
Sbjct: 736 DIVKEPAVVLRQEGVIIYSVGV---------FGSNVTQLEEISGRPEMVF--YVENFDIL 784

Query: 340 TKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEI 399
            +    LV  +C+  +  C +     +++ F+ID S S+    + +M +F+  + K  ++
Sbjct: 785 QRIEDDLVFGICSPRE-ECKR--IEVLDVVFVIDSSGSIDYDEYNIMKDFMIGLVKKADV 841

Query: 400 SDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFG 459
                +  A+++  D    F   D+ TK  V++V++N + M G T T +A+ F+  ++F 
Sbjct: 842 GKNQVRFGALKYADDPEVLFYLDDFGTKLEVISVLQNDQAMGGSTYTAEALGFS-DHMFT 900

Query: 460 PIRESP-NK---NFLVIVTDGQSY--DDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMA 513
             R S  NK     L+++TDG+S+  D +   A A  D GI + +VG+  A   +L  MA
Sbjct: 901 EARGSRLNKGVPQVLIVITDGESHDADKLNATAKALRDKGILVLAVGIDGANPVELLAMA 960

Query: 514 SKPKESHAFFTREFTGLEPIVSDVIRGIC 542
                   FF   F GL+ I SDV   +C
Sbjct: 961 G--SSDKYFFVETFGGLKGIFSDVTASVC 987



 Score =  136 bits (343), Expect = 4e-32
 Identities = 109/395 (27%), Positives = 183/395 (46%), Gaps = 23/395 (5%)

Query: 164 ADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFT 223
           AD+ FL+D S N  +  F+  K F+ +    L I      VGLV  S   K+   L    
Sbjct: 228 ADVVFLLDMSINGSEENFDYLKGFLEESVSALDIKENCMRVGLVAYSNETKVINSLSMGI 287

Query: 224 SAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRK--GIPKVVVVFIDGWPSDD 281
           +  +VL  I+ +  R G + TG A+K   ++ F+   G RK  G+P++ V+       D+
Sbjct: 288 NKSEVLQHIQNLSPRTGKAYTGAAIKKLRKEVFSARNGSRKNQGVPQIAVLVTHRDSEDN 347

Query: 282 IEEAGIVAREFGVNVFIVSVAKPIPEELGMVQD----------VTFVDKAVCRNNGFFSY 331
           + +A +  R  GV +F + +      +L  +             TF D A   +N  F  
Sbjct: 348 VTKAAVNLRREGVTIFTLGIEGASDTQLEKIASHPAEQYVSKLKTFADLAA--HNQTFLK 405

Query: 332 HMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVS 391
            + N    T  V    ++  T +   C  T     +I  LIDGS S   ++F  M  F+S
Sbjct: 406 KLRNQI--THTVSVFSERTETLKSG-CVDT--EEADIYLLIDGSGSTQATDFHEMKTFLS 460

Query: 392 NIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAIS 451
            +   F I+    ++ AVQ+      EF    YS K+++   I NIR M G T TG A++
Sbjct: 461 EVVGMFNIAPHKVRVGAVQYADSWDLEFEINKYSNKQDLGKAIENIRQMGGNTNTGAALN 520

Query: 452 FTVRNVFGPIRESPNK--NFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDL 509
           FT+  +    ++  NK    LV++T+G S D +  PA    +  I ++++G+  A    L
Sbjct: 521 FTLSLLQKAKKQRGNKVPCHLVVLTNGMSKDSILEPANRLREEHIRVYAIGIKEANQTQL 580

Query: 510 KDMASKPKESHAFFTREFTGLEPIVSDVIRGICRD 544
           +++A   +E   ++  +F  L+ I + V++ IC +
Sbjct: 581 REIAG--EEKRVYYVHDFDALKDIRNQVVQEICTE 613



 Score =  130 bits (326), Expect = 4e-30
 Identities = 106/402 (26%), Positives = 188/402 (46%), Gaps = 32/402 (7%)

Query: 160  KDCKA----DIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKI 215
            ++CK     D+ F+ID S +I    +N+ K+F+  +     +G      G ++ ++ P++
Sbjct: 800  EECKRIEVLDVVFVIDSSGSIDYDEYNIMKDFMIGLVKKADVGKNQVRFGALKYADDPEV 859

Query: 216  EFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVR--KGIPKVVVVF 273
             FYL +F +  +V+  ++     GG++ T +AL  +    FT   G R  KG+P+V++V 
Sbjct: 860  LFYLDDFGTKLEVISVLQNDQAMGGSTYTAEALGFS-DHMFTEARGSRLNKGVPQVLIVI 918

Query: 274  IDG--WPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSY 331
             DG    +D +       R+ G+ V  V +    P EL  +   +  DK          Y
Sbjct: 919  TDGESHDADKLNATAKALRDKGILVLAVGIDGANPVELLAMAGSS--DK----------Y 966

Query: 332  HMPNWFGTTKYV-KPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFV 390
                 FG  K +   +   +C   ++ C     + V++ FL+DGS+S+  ++F+ M EF+
Sbjct: 967  FFVETFGGLKGIFSDVTASVCNSSKVDCE---IDKVDLVFLMDGSTSIQPNDFKKMKEFL 1023

Query: 391  SNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAI 450
            +++ + F++S    +I A QF+     EF    +  ++ +   I NI+ + G T  G A+
Sbjct: 1024 ASVVQDFDVSLNRVRIGAAQFSDTYHPEFPLGTFIGEKEISFQIENIKQIFGNTHIGAAL 1083

Query: 451  SFTVRNVFGPIRES----PNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPL 506
               V + F P   S         L+++TDGQS D+V   A A    GI I+SVG+    +
Sbjct: 1084 R-EVEHYFRPDMGSRINTGTPQVLLVLTDGQSQDEVAQAAEALRHRGIDIYSVGI--GDV 1140

Query: 507  DDLKDMASKPKESHAFFTREFTGLEPIVSDVIRGICRDFLES 548
            DD + +              F  L+ +   ++R IC    ES
Sbjct: 1141 DDQQLIQITGTAEKKLTVHNFDELKKVNKRIVRNICTTAGES 1182



 Score =  121 bits (304), Expect = 1e-27
 Identities = 103/378 (27%), Positives = 165/378 (43%), Gaps = 18/378 (4%)

Query: 164 ADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFT 223
           AD+ FL+D S  +G + F   K F+ K+   L I  +   V L Q S+    EF+L  F 
Sbjct: 26  ADVVFLVDSSDRLGSKSFPFVKMFITKMISSLPIEADKYRVALAQYSDKLHSEFHLSTFK 85

Query: 224 SAKDVLFAI-KEVGFRGGNSNTGKALKHTAQKFFTVDAGVR--KGIPKVVVVFIDGWPSD 280
               +L  + K  GF GG+   GKAL+   + +F+  A  R  K  P ++VV       D
Sbjct: 86  GRSPMLNHLRKNFGFIGGSLQIGKALQEAHRTYFSAPANGRDKKQFPPILVVLASSESED 145

Query: 281 DIEEAGIVAREFGVNVFIVSVAKPIPEEL-GMVQDVTFVDKAVCRNNGFFSYHMPNWFGT 339
           ++EEA    R+ GV +  V V K   E L  M       +    R+   FS +M      
Sbjct: 146 NVEEASKALRKDGVKIISVGVQKASEENLKAMATSQFHFNLRTVRDLSMFSQNM------ 199

Query: 340 TKYVKPLVQKLCTHEQMMCSKTCY--NSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTF 397
           T  +K +++        +  + C   +  ++ FL+D S +  + NF  +  F+       
Sbjct: 200 THIIKDVIKYKEGAVDDIFVEACQGPSMADVVFLLDMSINGSEENFDYLKGFLEESVSAL 259

Query: 398 EISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNV 457
           +I +   ++  V ++ + +   S +    K  VL  I+N+   +G   TG AI    + V
Sbjct: 260 DIKENCMRVGLVAYSNETKVINSLSMGINKSEVLQHIQNLSPRTGKAYTGAAIKKLRKEV 319

Query: 458 FGPIRESPNKN-----FLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDM 512
           F   R    KN       V+VT   S D+V   A      G+TIF++G+  A    L+ +
Sbjct: 320 FS-ARNGSRKNQGVPQIAVLVTHRDSEDNVTKAAVNLRREGVTIFTLGIEGASDTQLEKI 378

Query: 513 ASKPKESHAFFTREFTGL 530
           AS P E +    + F  L
Sbjct: 379 ASHPAEQYVSKLKTFADL 396



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 45/182 (24%), Positives = 84/182 (46%), Gaps = 9/182 (4%)

Query: 367 NIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYST 426
           ++ FL+D S  +G  +F  +  F++ +  +  I     ++A  Q++    +EF  + +  
Sbjct: 27  DVVFLVDSSDRLGSKSFPFVKMFITKMISSLPIEADKYRVALAQYSDKLHSEFHLSTFKG 86

Query: 427 KENVLAVIR-NIRYMSGGTATGDAISFTVRNVFG-PIRESPNKNF---LVIVTDGQSYDD 481
           +  +L  +R N  ++ G    G A+    R  F  P      K F   LV++   +S D+
Sbjct: 87  RSPMLNHLRKNFGFIGGSLQIGKALQEAHRTYFSAPANGRDKKQFPPILVVLASSESEDN 146

Query: 482 VQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFT----GLEPIVSDV 537
           V+  + A    G+ I SVGV  A  ++LK MA+     +    R+ +     +  I+ DV
Sbjct: 147 VEEASKALRKDGVKIISVGVQKASEENLKAMATSQFHFNLRTVRDLSMFSQNMTHIIKDV 206

Query: 538 IR 539
           I+
Sbjct: 207 IK 208



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 80/414 (19%), Positives = 160/414 (38%), Gaps = 71/414 (17%)

Query: 158  GNKDCKA---DIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTE----GPHVGLVQAS 210
            G  +C     ++ F +D S ++ ++ F   K  +  +   + +       G H+ ++  +
Sbjct: 1747 GKPECPVHPTELVFALDHSRDVTEQEFERMKEMMAFLVRDIKVRENSCPVGAHIAILSYN 1806

Query: 211  EHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNT--GKALKHTAQKFFTVDAGVRKGIP- 267
             H +      +      +L  I+ + +   +++   G+A++  ++  F      ++ +P 
Sbjct: 1807 SHARHLVRFSDAYKKSQLLREIETIPYERSSASREIGRAMRFISRNVF------KRTLPG 1860

Query: 268  ---KVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCR 324
               + +  F     S D       A EFG    I     P+      V  V     A+  
Sbjct: 1861 AHTRKIATFFSSGQSADAHSITTAAMEFGALEII-----PVVITFSNVPSVRRAF-AIDD 1914

Query: 325  NNGFFSYHMPNWFGTTKYVKPLVQKL--CTHEQMMCSKTC----------YNSVNIAFLI 372
               F    +P+      Y+ P +++L  CT    +C               + ++ AFL+
Sbjct: 1915 TGTFQVIVVPSG---ADYI-PALERLQRCTFCYDVCKPDASCDQARPPPVQSYMDAAFLL 1970

Query: 373  DGSSSVGDSNFRLMLEFVSNIAKTFEI------SDIGAKIAAVQFTYDQ----------R 416
            D S ++G + F  +  F+  +   FEI      S  G ++A +                R
Sbjct: 1971 DASRNMGSAEFEDIRAFLGALLDHFEITPEPETSVTGDRVALLSHAPPDFLPNTQKSPVR 2030

Query: 417  TEFSFTDYSTKENVLA-VIRNIRYMSGGTATGDAISFTVRNVFGPIRESPN--KNFLVIV 473
             EF+ T Y +K  +   V  +++ ++G    G A+ +T+ NVF     +PN  +N ++ V
Sbjct: 2031 AEFNLTTYRSKRLMKRHVHESVKQLNGDAFIGHALQWTLDNVF---LSTPNLRRNKVIFV 2087

Query: 474  TDGQSYDDVQGP-------AAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESH 520
                    + G         A      + +FS+G  W    +L+D+AS P + H
Sbjct: 2088 ISAGETSHLDGEILKKESLRAKCQGYALFVFSLGPIWDD-KELEDLASHPLDHH 2140


>gi|55743098 alpha 3 type VI collagen isoform 1 precursor [Homo
           sapiens]
          Length = 3177

 Score =  154 bits (388), Expect = 3e-37
 Identities = 119/421 (28%), Positives = 190/421 (45%), Gaps = 38/421 (9%)

Query: 144 PTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPH 203
           PT    ++  + K G     ADI FL+D S+ IG+  F L + F+  V   L +G    H
Sbjct: 21  PTTHAQQQQADVKNG---AAADIIFLVDSSWTIGEEHFQLVREFLYDVVKSLAVGENDFH 77

Query: 204 VGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVR 263
             LVQ + +P  EF L  + + ++VL  I  + + GG + TGK L++  Q   T  AG R
Sbjct: 78  FALVQFNGNPHTEFLLNTYRTKQEVLSHISNMSYIGGTNQTGKGLEYIMQSHLTKAAGSR 137

Query: 264 --KGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKA 321
              G+P+V+VV  DG   D +       +   VNVF + V            D   + + 
Sbjct: 138 AGDGVPQVIVVLTDGHSKDGLALPSAELKSADVNVFAIGVED---------ADEGALKEI 188

Query: 322 VCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSK----------TCYNSVNIAFL 371
                    +++ N+      V  LV   C H  +   +          T  +S +I FL
Sbjct: 189 ASEPLNMHMFNLENFTSLHDIVGNLVS--CVHSSVSPERAGDTETLKDITAQDSADIIFL 246

Query: 372 IDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVL 431
           IDGS++ G  NF ++L+F+ N+ +   I     ++  VQF+ + RT FS   YSTK  VL
Sbjct: 247 IDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYSTKAQVL 306

Query: 432 AVIRNIRYMSGGTAT-GDAISFTVRNVF----GPIRESPNKNFLVIVTDGQSYDDVQGPA 486
             ++ + +  G  A  G A+ F V N F    G   E      LV+++ G S D+++   
Sbjct: 307 GAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSSDEIRYGV 366

Query: 487 AAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFT----REFTGLEPIVSDVIRGIC 542
            A   A +  F +G   A   +L+ +A+   + +  FT    R F  L+  +   I G+ 
Sbjct: 367 VALKQASVFSFGLGAQAASRAELQHIAT---DDNLVFTVPEFRSFGDLQEKLLPYIVGVA 423

Query: 543 R 543
           +
Sbjct: 424 Q 424



 Score =  144 bits (362), Expect = 3e-34
 Identities = 117/401 (29%), Positives = 186/401 (46%), Gaps = 23/401 (5%)

Query: 128 SSTQEATGQAVSTAHPPTG-KRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKN 186
           +S  +  G  VS  H     +R   T   K       ADI FLIDGS N G   F +  +
Sbjct: 204 TSLHDIVGNLVSCVHSSVSPERAGDTETLKDITAQDSADIIFLIDGSNNTGSVNFAVILD 263

Query: 187 FVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGN-SNTG 245
           F+  +   L IGT+   VG+VQ S+ P+  F L  +++   VL A+K +GF GG  +N G
Sbjct: 264 FLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYSTKAQVLGAVKALGFAGGELANIG 323

Query: 246 KALKHTAQKFFTVDAG--VRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAK 303
            AL    +  FT   G  V +G+P+V+V+   G  SD+I    +  ++  V  F +    
Sbjct: 324 LALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSSDEIRYGVVALKQASVFSFGLGAQA 383

Query: 304 PIPEELGMVQDVTFVDKAVCRNNGFFSYH------MPNWFGTTKYVKPLVQKLCTHEQMM 357
               EL   Q +   D  V     F S+       +P   G  +  + +V K  T    +
Sbjct: 384 ASRAEL---QHIATDDNLVFTVPEFRSFGDLQEKLLPYIVGVAQ--RHIVLKPPTIVTQV 438

Query: 358 CSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRT 417
                 N  +I FL+DGSS++G +NF  + +F++ + +  EI     ++A  Q+    R 
Sbjct: 439 IE---VNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRP 495

Query: 418 EFSFTDYSTKENVLAVIRNIRYMSGGTA-TGDAISFTVRNVF----GPIRESPNKNFLVI 472
           EF F  + TK  V+  +R ++ + G    TG A+ F   N+F    G          LV+
Sbjct: 496 EFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVL 555

Query: 473 VTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMA 513
           +T G+S D++  PA     + I  F++G   A   +L+++A
Sbjct: 556 ITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIA 596



 Score =  138 bits (347), Expect = 1e-32
 Identities = 111/387 (28%), Positives = 181/387 (46%), Gaps = 25/387 (6%)

Query: 163 KADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNF 222
           K DI FL+DGS  +G   FN  ++F+ KV   L IG +   V + Q ++  + EFY    
Sbjct: 443 KRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTH 502

Query: 223 TSAKDVLFAIKEVGFRGGNS-NTGKALKHTAQKFFTVDAGVR--KGIPKVVVVFIDGWPS 279
            + ++V+ A++++    G++  TG AL       FT  AG R  +GIPK++V+   G   
Sbjct: 503 PTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSL 562

Query: 280 DDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGT 339
           D+I +     +   +  F +        EL   +++ F    V          +P  F  
Sbjct: 563 DEISQPAQELKRSSIMAFAIGNKGADQAEL---EEIAFDSSLV---------FIPAEFRA 610

Query: 340 TKYVKPLVQKLCTHEQMMCSKTCY-NSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFE 398
                 L   L     +  +   + N  +I FL+DGS++VG +NF  + +FV N+  + +
Sbjct: 611 APLQGMLPGLLAPLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLD 670

Query: 399 ISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSG-GTATGDAISFTVRNV 457
           I +   ++  VQF+    TEFS   Y TK ++L  +R ++   G G  TG A+S+   N 
Sbjct: 671 IGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANH 730

Query: 458 F-----GPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDM 512
           F       IRE      L+++T GQS D     A A   AGI  F VG + A   +L+ +
Sbjct: 731 FTEAGGSRIREHV-PQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQI 789

Query: 513 ASKPKESHAFFTREFTGLEPIVSDVIR 539
           A  P  S  +   +F+ L  +   +I+
Sbjct: 790 AFNP--SLVYLMDDFSSLPALPQQLIQ 814



 Score =  129 bits (325), Expect = 5e-30
 Identities = 106/379 (27%), Positives = 168/379 (44%), Gaps = 12/379 (3%)

Query: 163  KADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNF 222
            K D+ FLIDGS + G   F   +  + ++   L +G +   V ++Q S+ PK+EF L   
Sbjct: 1231 KRDVVFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAH 1289

Query: 223  TSAKDVLFAIKEVGFRGGNS-NTGKALKHTAQKFFTVDAGVR--KGIPKVVVVFIDGWPS 279
            +S  +V  A++ +  +GG   N G AL++ ++  F    G R  +G+P+ +V+   G   
Sbjct: 1290 SSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSD 1349

Query: 280  DDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGT 339
            D++++  +  ++FGV  F ++      EEL  +        +V       S         
Sbjct: 1350 DEVDDPAVELKQFGVAPFTIA-RNADQEELVKISLSPEYVFSVSTFRELPSLEQKLLTPI 1408

Query: 340  TKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEI 399
            T      +QKL    +        ++ +I FLID S  V    F  + +FVS I +   I
Sbjct: 1409 TTLTSEQIQKLLASTRYPPPAVESDAADIVFLIDSSEGVRPDGFAHIRDFVSRIVRRLNI 1468

Query: 400  SDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTA-TGDAISFTVRNVF 458
                 ++  VQF+ D   EF    Y ++  VL  IR +R   G    TG A+ F  RN+F
Sbjct: 1469 GPSKVRVGVVQFSNDVFPEFYLKTYRSQAPVLDAIRRLRLRGGSPLNTGKALEFVARNLF 1528

Query: 459  ----GPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMAS 514
                G   E      LV+V  G+S DDV   A     +GI    VG       +L+ + +
Sbjct: 1529 VKSAGSRIEDGVPQHLVLVLGGKSQDDVSRFAQVIRSSGIVSLGVGDRNIDRTELQTITN 1588

Query: 515  KPKESHAFFTREFTGLEPI 533
             P+    F  REF  L  I
Sbjct: 1589 DPR--LVFTVREFRELPNI 1605



 Score =  127 bits (318), Expect = 3e-29
 Identities = 101/383 (26%), Positives = 180/383 (46%), Gaps = 30/383 (7%)

Query: 147 KRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGL 206
           + L  TPE  +     K DI FL+DGS N+G+  F   ++FV  +   L IG +   VGL
Sbjct: 625 RTLSGTPEVHSN----KRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGL 680

Query: 207 VQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNS-NTGKALKHTAQKFFTVDAG--VR 263
           VQ S+ P  EF L  + +  D+L  ++++  +GG+  NTG AL +     FT   G  +R
Sbjct: 681 VQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIR 740

Query: 264 KGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVC 323
           + +P+++++   G   D   +A       G+  F V  ++    EL   + + F      
Sbjct: 741 EHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAEL---EQIAF------ 791

Query: 324 RNNGFFSYHMPNWFGTTKYVKPLVQKLCTH-----EQMMCSKTCYNSVNIAFLIDGSSSV 378
             N    Y M ++       + L+Q L T+     E++  ++   +  +I FL DGS+++
Sbjct: 792 --NPSLVYLMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQP-ESKRDILFLFDGSANL 848

Query: 379 GDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIR 438
               F ++ +F+  I     +   G +IA  Q++ D + E  F ++ +K  +L +++ ++
Sbjct: 849 -VGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMK 907

Query: 439 YMSGGTAT-GDAISFTVRNVF----GPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAG 493
             +G     G A+ +  R +F    G   E     FLV++  G+S D V GPA+    +G
Sbjct: 908 IKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSG 967

Query: 494 ITIFSVGVAWAPLDDLKDMASKP 516
           +  F      A   +L+ +   P
Sbjct: 968 VVPFIFQAKNADPAELEQIVLSP 990



 Score =  123 bits (308), Expect = 5e-28
 Identities = 104/414 (25%), Positives = 187/414 (45%), Gaps = 34/414 (8%)

Query: 138  VSTAHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGI 197
            +   HP     LK            + D+ FL+DGS  + +  F L K FV +V   L +
Sbjct: 1002 IGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDV 1060

Query: 198  GTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGG-NSNTGKALKHTAQKFF 256
            G +   V +VQ S+  + EFYL ++ + +DV+ A++++   GG   NTG AL+   +   
Sbjct: 1061 GQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNIL 1120

Query: 257  TVDAGVR--KGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQD 314
               AG R  +G+P++++V       DD+    +V +  G     + +      ++  +Q 
Sbjct: 1121 VSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGN---ADITEMQT 1177

Query: 315  VTFVDKAVCRNNGFFSYHMPNW--FGTTKYV-KPLVQKLCTHE--------QMMCSKTCY 363
            ++F+          F+  +P +   GT + V    V +L   E        Q + S    
Sbjct: 1178 ISFIPD--------FAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGVG 1229

Query: 364  NSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTD 423
               ++ FLIDGS S G   F+ +   +  +    ++     ++A +QF+ D + EF    
Sbjct: 1230 GKRDVVFLIDGSQSAG-PEFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNA 1288

Query: 424  YSTKENVLAVIRNIRYMSGGTA-TGDAISFTVRNVF----GPIRESPNKNFLVIVTDGQS 478
            +S+K+ V   ++ +R   G     G+A+ +  RN+F    G   E     FLV+++ G+S
Sbjct: 1289 HSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKS 1348

Query: 479  YDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFT-REFTGLE 531
             D+V  PA      G+  F++    A  ++L  ++  P+   +  T RE   LE
Sbjct: 1349 DDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSPEYVFSVSTFRELPSLE 1401



 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 106/420 (25%), Positives = 177/420 (42%), Gaps = 53/420 (12%)

Query: 137  AVSTAHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLG 196
            A + A P         PEKK      KADI FL+DGS N  +  F     FV ++   + 
Sbjct: 1617 AATPAPPGVDTPPPSRPEKK------KADIVFLLDGSINFRRDSFQEVLRFVSEIVDTVY 1670

Query: 197  IGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGG-NSNTGKALKHTAQKF 255
               +   VGLVQ +  P  EF+LK+F++ + ++ AI +V ++GG ++NT   L+H     
Sbjct: 1671 EDGDSIQVGLVQYNSDPTDEFFLKDFSTKRQIIDAINKVVYKGGRHANTKVGLEHLRVNH 1730

Query: 256  FTVDAGVR--KGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQ 313
            F  +AG R  + +P++  V   G   +D ++  +   + GV VF V V     EE+G + 
Sbjct: 1731 FVPEAGSRLDQRVPQIAFVITGGKSVEDAQDVSLALTQRGVKVFAVGVRNIDSEEVGKI- 1789

Query: 314  DVTFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKL--CTHEQMM-----CSKTCYNSV 366
                       +N   ++ + N    ++  + +++ L    HE +       +K C   V
Sbjct: 1790 ----------ASNSATAFRVGNVQELSELSEQVLETLHDAMHETLCPGVTDAAKACNLDV 1839

Query: 367  NIAFLIDGSSS----VGDSNFRLMLEFVSN-IAKTFEISDIGAKIAAVQFTYDQRT---- 417
             + F  DGS      V    F   ++ + N I++   +S  G +   V+ +    T    
Sbjct: 1840 ILGF--DGSRDQNVFVAQKGFESKVDAILNRISQMHRVSCSGGRSPTVRVSVVANTPSGP 1897

Query: 418  --EFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRESPNKNFLVIV-- 473
               F F +Y  +  +L   RN+R       T D    T++      R+S   +  V++  
Sbjct: 1898 VEAFDFDEY--QPEMLEKFRNMRSQHPYVLTED----TLKVYLNKFRQSSPDSVKVVIHF 1951

Query: 474  TDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPI 533
            TDG       G  A  H A   +   GV    L  L+ + +  +  H  F R F    P+
Sbjct: 1952 TDG-----ADGDLADLHRASENLRQEGVRALILVGLERVVNLERLMHLEFGRGFMYDRPL 2006



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 33/125 (26%), Positives = 61/125 (48%), Gaps = 20/125 (16%)

Query: 366  VNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIG------AKIAAVQFTYDQ---- 415
            +++AF++D + +     F  M ++++ + +  ++S         A++A VQ    +    
Sbjct: 2618 IDMAFILDSAETTTLFQFNEMKKYIAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDN 2677

Query: 416  ------RTEFSFTDYSTKENVLAVI-RNIRYMSGGTATGDAISFTVRNVFGPIRESPNKN 468
                  + EFS TDY +KE ++  + R +  + G  A G AI +T+ NVF     +PN  
Sbjct: 2678 ASMPPVKVEFSLTDYGSKEKLVDFLSRGMTQLQGTRALGSAIEYTIENVF---ESAPNPR 2734

Query: 469  FLVIV 473
             L IV
Sbjct: 2735 DLKIV 2739



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 30/101 (29%), Positives = 47/101 (46%), Gaps = 6/101 (5%)

Query: 368  IAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDI----GAKIAAVQFTYDQRTEFSFTD 423
            +AF +D S  V    F  M + V +I     I++     GA++A V +  +  TE  F D
Sbjct: 2403 LAFALDTSEGVNQDTFGRMRDVVLSIVNDLTIAESNCPRGARVAVVTYNNEVTTEIRFAD 2462

Query: 424  YSTKENVLAVIRNIR--YMSGGTATGDAISFTVRNVFGPIR 462
               K  +L  I+N++    S   +   A+SF  RN F  +R
Sbjct: 2463 SKRKSVLLDKIKNLQVALTSKQQSLETAMSFVARNTFKRVR 2503



 Score = 33.5 bits (75), Expect = 0.52
 Identities = 32/150 (21%), Positives = 62/150 (41%), Gaps = 20/150 (13%)

Query: 154  EKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTE---GPHVGLVQAS 210
            +++    D   D+AF++D +      +FN  K ++  +   L +  +     H   V   
Sbjct: 2608 DRRAAGSDVDIDMAFILDSAETTTLFQFNEMKKYIAYLVRQLDMSPDPKASQHFARVAVV 2667

Query: 211  EHP-------------KIEFYLKNFTSAKDVL-FAIKEVGFRGGNSNTGKALKHTAQKFF 256
            +H              K+EF L ++ S + ++ F  + +    G    G A+++T +  F
Sbjct: 2668 QHAPSESVDNASMPPVKVEFSLTDYGSKEKLVDFLSRGMTQLQGTRALGSAIEYTIENVF 2727

Query: 257  TVDAGVRKGIPKVVVVFIDG-WPSDDIEEA 285
                  R    K+VV+ + G  P   +EEA
Sbjct: 2728 ESAPNPRD--LKIVVLMLTGEVPEQQLEEA 2755


>gi|183583553 collagen, type XXIX, alpha 1 [Homo sapiens]
          Length = 2526

 Score =  147 bits (372), Expect = 2e-35
 Identities = 112/397 (28%), Positives = 198/397 (49%), Gaps = 20/397 (5%)

Query: 160 KDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYL 219
           KD  AD+ FL+D S   G    +LQ  F+  +   + +      +GL+  S   K   +L
Sbjct: 231 KDSLADLVFLVDESLGTGGNLRHLQ-TFLENITSSMDVKENCMRLGLMSYSNSAKTISFL 289

Query: 220 KNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRK--GIPKVVVVFIDGW 277
           K+ T+  +    IK +  + G SNTG A+    +  F+   G R+  G+P++ V+     
Sbjct: 290 KSSTTQSEFQQQIKNLSIQVGKSNTGAAIDQMRRDGFSESYGSRRAQGVPQIAVLVTHRP 349

Query: 278 PSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWF 337
             D++ +A +  R   VNVF +S+      +L  +  V++  +     +   SY     +
Sbjct: 350 SDDEVHDAALNLRLEDVNVFALSIQGANNTQLEEI--VSYPPEQTI--STLKSYADLETY 405

Query: 338 GTTKYVKPLVQKLCTH-----EQMMCSKT-CYNS--VNIAFLIDGSSSVGDSNFRLMLEF 389
            +TK++K L  ++ +      EQ    KT C ++   +I FLIDGSSS+ +  F  +  F
Sbjct: 406 -STKFLKKLQNEIWSQISTYAEQRNLDKTGCVDTKEADIHFLIDGSSSIQEKQFEQIKRF 464

Query: 390 VSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDA 449
           +  + + F I     ++  VQ++ D   EF  TDYS   ++   I NI+ ++GGT TG A
Sbjct: 465 MLEVTEMFSIGPDKVRVGVVQYSDDTEVEFYITDYSNDIDLRKAIFNIKQLTGGTYTGKA 524

Query: 450 ISFTVRNVFGPIRESPNK--NFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLD 507
           + + ++ +   +++  +K   +L+++TDG S D V  PA       IT+ +VG+  A   
Sbjct: 525 LDYILQIIKNGMKDRMSKVPCYLIVLTDGMSTDRVVEPAKRLRAEQITVHAVGIGAANKI 584

Query: 508 DLKDMASKPKESHAFFTREFTGLEPIVSDVIRGICRD 544
           +L+++A   KE    F + F  L+ I ++V+R IC +
Sbjct: 585 ELQEIAG--KEERVSFGQNFDALKSIKNEVVREICAE 619



 Score =  146 bits (368), Expect = 5e-35
 Identities = 117/392 (29%), Positives = 188/392 (47%), Gaps = 26/392 (6%)

Query: 156 KTGNKDCK-ADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPK 214
           KTG  D K ADI FLIDGS +I +++F   K F+ +V  M  IG +   VG+VQ S+  +
Sbjct: 432 KTGCVDTKEADIHFLIDGSSSIQEKQFEQIKRFMLEVTEMFSIGPDKVRVGVVQYSDDTE 491

Query: 215 IEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFI 274
           +EFY+ ++++  D+  AI  +    G + TGKAL +  Q            +P  ++V  
Sbjct: 492 VEFYITDYSNDIDLRKAIFNIKQLTGGTYTGKALDYILQIIKNGMKDRMSKVPCYLIVLT 551

Query: 275 DGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMP 334
           DG  +D + E     R   + V  V +      EL   Q++   ++ V            
Sbjct: 552 DGMSTDRVVEPAKRLRAEQITVHAVGIGAANKIEL---QEIAGKEERVSFGQN------- 601

Query: 335 NWFGTTKYVK-PLVQKLCTHEQMMCSKTCYN-SVNIAFLIDGSSSVGDSNFRLMLEFVSN 392
             F   K +K  +V+++C        K C +   +I FL+D S S+G+ NFR M  F+ N
Sbjct: 602 --FDALKSIKNEVVREIC------AEKGCEDMKADIMFLVDSSWSIGNENFRKMKIFMKN 653

Query: 393 IAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISF 452
           +    +I     +I  VQF+   + EF    Y T++ +   I  +  ++ GT TG A++F
Sbjct: 654 LLTKIQIGADKTQIGVVQFSDKTKEEFQLNRYFTQQEISDAIDRMSLINEGTLTGKALNF 713

Query: 453 TVRNVFGPIRES--PNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLK 510
            V   F   + +    K FL+++TDG + DDV+ PA       +TIFSVGV  A    L+
Sbjct: 714 -VGQYFTHSKGARLGAKKFLILITDGVAQDDVRDPARILRGKDVTIFSVGVYNANRSQLE 772

Query: 511 DMASKPKESHAFFTREFTGLEPIVSDVIRGIC 542
           +++     S  F    F  L+ +   +I  +C
Sbjct: 773 EISG--DSSLVFHVENFDHLKALERKLIFRVC 802



 Score =  111 bits (278), Expect = 1e-24
 Identities = 97/378 (25%), Positives = 163/378 (43%), Gaps = 13/378 (3%)

Query: 164 ADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFT 223
           AD+ FL+D S ++G + F   K F+ K+   L I      V L Q S+    EF+L  F 
Sbjct: 29  ADVVFLVDSSDHLGPKSFPFVKTFINKMINSLPIEANKYRVALAQYSDEFHSEFHLSTFK 88

Query: 224 SAKDVLFAIKE-VGFRGGNSNTGKALKHTAQKFFT--VDAGVRKGIPKVVVVFIDGWPSD 280
               +L  +K+   F GG+   GKAL+   + +F+  ++   RK  P ++VV       D
Sbjct: 89  GRSPMLNHLKKNFQFIGGSLQIGKALQEAHRTYFSAPINGRDRKQFPPILVVLASAESED 148

Query: 281 DIEEAGIVAREFGVNVFIVSVAKPIPEEL-GMVQDVTFVDKAVCRNNGFFSYHMPNWF-G 338
           ++EEA    ++ GV +  V V K   E L  M       +    R+   FS +M      
Sbjct: 149 EVEEASKALQKDGVKIISVGVQKASEENLKAMATSHFHFNLRTIRDLSTFSQNMTQIIKD 208

Query: 339 TTKYVKPLVQ-KLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTF 397
            TKY +  V   +  H  + C K   +  ++ FL+D S   G  N R +  F+ NI  + 
Sbjct: 209 VTKYKEGAVDADMQVHFPISCQKD--SLADLVFLVDESLGTG-GNLRHLQTFLENITSSM 265

Query: 398 EISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNV 457
           ++ +   ++  + ++   +T       +T+      I+N+    G + TG AI    R+ 
Sbjct: 266 DVKENCMRLGLMSYSNSAKTISFLKSSTTQSEFQQQIKNLSIQVGKSNTGAAIDQMRRDG 325

Query: 458 F----GPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMA 513
           F    G  R        V+VT   S D+V   A       + +F++ +  A    L+++ 
Sbjct: 326 FSESYGSRRAQGVPQIAVLVTHRPSDDEVHDAALNLRLEDVNVFALSIQGANNTQLEEIV 385

Query: 514 SKPKESHAFFTREFTGLE 531
           S P E      + +  LE
Sbjct: 386 SYPPEQTISTLKSYADLE 403



 Score =  111 bits (277), Expect = 2e-24
 Identities = 111/440 (25%), Positives = 191/440 (43%), Gaps = 40/440 (9%)

Query: 127  KSSTQEATGQAVSTAHPPTGKRLKKTPEKKTGN----KDCKA----DIAFLIDGSFNIGQ 178
            +S  +E +G +    H      LK    K         DCK     D+ F++D S +I +
Sbjct: 768  RSQLEEISGDSSLVFHVENFDHLKALERKLIFRVCALHDCKRITLLDVVFVLDHSGSIKK 827

Query: 179  RRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFR 238
            +  +   N    +     +G +    G ++ S+ P I FYL  +++   ++  +++    
Sbjct: 828  QYQDHMINLTIHLVKKADVGRDRVQFGALKYSDQPNILFYLNTYSNRSAIIENLRKRRDT 887

Query: 239  GGNSNTGKALKHTAQKFFTVDAG--VRKGIPKVVVVFIDG--WPSDDIEEAGIVAREFGV 294
            GGN+ T KALKH A   FT + G  +++ + ++++V  DG     D + +  +  R  G+
Sbjct: 888  GGNTYTAKALKH-ANALFTEEHGSRIKQNVKQMLIVITDGESHDHDQLNDTALELRNKGI 946

Query: 295  NVFIVSVAKPIPEEL-GMVQDVTFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQ-KLCT 352
             +F V V K   +EL GM  +         +NN  +  +    F   K V  LVQ ++CT
Sbjct: 947  TIFAVGVGKANQKELEGMAGN---------KNNTIYVDN----FDKLKDVFTLVQERMCT 993

Query: 353  HEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFT 412
                +C        ++ FL DGS  V +S+F  M  F+S++   F+I     KI   QF 
Sbjct: 994  EAPEVCH---LQEADVIFLCDGSDRVSNSDFVTMTTFLSDLIDNFDIQSQRMKIGMAQFG 1050

Query: 413  YDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVF----GPIRESPNKN 468
             + ++     +  TK      I+N+   SGG    D     V N+F    G  R +    
Sbjct: 1051 SNYQSIIELKNSLTKTQWKTQIQNVS-KSGGFPRIDFALKKVSNMFNLHAGGRRNAGVPQ 1109

Query: 469  FLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFT 528
             LV++T G    DV        D GI +  +G+     + L  +    ++   F  ++F 
Sbjct: 1110 TLVVITSGDPRYDVADAVKTLKDLGICVLVLGIGDVYKEHLLPITGNSEKIITF--QDFD 1167

Query: 529  GLEPIVSDVIRGICRDFLES 548
             L+ +  DV + I R+  +S
Sbjct: 1168 KLKNV--DVKKRIIREICQS 1185



 Score = 63.9 bits (154), Expect = 4e-10
 Identities = 42/182 (23%), Positives = 87/182 (47%), Gaps = 5/182 (2%)

Query: 367 NIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYST 426
           ++ FL+D S  +G  +F  +  F++ +  +  I     ++A  Q++ +  +EF  + +  
Sbjct: 30  DVVFLVDSSDHLGPKSFPFVKTFINKMINSLPIEANKYRVALAQYSDEFHSEFHLSTFKG 89

Query: 427 KENVLAVIR-NIRYMSGGTATGDAISFTVRNVFG-PIRESPNKNF---LVIVTDGQSYDD 481
           +  +L  ++ N +++ G    G A+    R  F  PI     K F   LV++   +S D+
Sbjct: 90  RSPMLNHLKKNFQFIGGSLQIGKALQEAHRTYFSAPINGRDRKQFPPILVVLASAESEDE 149

Query: 482 VQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRGI 541
           V+  + A    G+ I SVGV  A  ++LK MA+     +    R+ +     ++ +I+ +
Sbjct: 150 VEEASKALQKDGVKIISVGVQKASEENLKAMATSHFHFNLRTIRDLSTFSQNMTQIIKDV 209

Query: 542 CR 543
            +
Sbjct: 210 TK 211



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 44/176 (25%), Positives = 81/176 (46%), Gaps = 21/176 (11%)

Query: 366  VNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEI------SDIGAKIAAVQFT---YDQR 416
            +++AFLID S  VG   F+ +  F++++   F I      S +G ++A + ++   Y   
Sbjct: 2290 MDVAFLIDASQRVGSDEFKEVKAFITSVLDYFHIAPTPLTSTLGDRVAVLSYSPPGYMPN 2349

Query: 417  T-------EFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVF-GPIRESPNKN 468
            T       EF    Y++   +   +++ + ++G    G A+ +T+ NVF G      NK 
Sbjct: 2350 TEECPVYLEFDLVTYNSIHQMKHHLQDSQQLNGDVFIGHALQWTIDNVFVGTPNLRKNKV 2409

Query: 469  FLVI---VTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLD-DLKDMASKPKESH 520
              VI    T+    D ++  +  A   G +IF         D +L+++AS P + H
Sbjct: 2410 IFVISAGETNSLDKDVLRNVSLRAKCQGYSIFVFSFGPKHNDKELEELASHPLDHH 2465



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 32/140 (22%), Positives = 61/140 (43%), Gaps = 7/140 (5%)

Query: 346  LVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISD---- 401
            L++ L  H      K       + F +D S  V + +F    + +++I     I +    
Sbjct: 1737 LIRFLREHSPCWKEKCPAYPTELVFALDNSYDVTEESFNKTRDIITSIVNDLNIRENNCP 1796

Query: 402  IGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYM--SGGTATGDAISFTVRNVFG 459
            +GA++A V +         ++DY+ K+ +L  +  I+Y   +     G+A+ F  RNVF 
Sbjct: 1797 VGARVAMVSYNSGTSYLIRWSDYNRKKQLLQQLSQIKYQDTTEPRDVGNAMRFVTRNVFK 1856

Query: 460  PIRESPN-KNFLVIVTDGQS 478
                  N +   V  ++GQ+
Sbjct: 1857 RTYAGANVRRVAVFFSNGQT 1876



 Score = 38.1 bits (87), Expect = 0.021
 Identities = 66/286 (23%), Positives = 107/286 (37%), Gaps = 48/286 (16%)

Query: 97   GREN-YSSVDANG------IQSQMLSRWSASFTVTKGKSSTQEATGQAVSTAHPPTGKRL 149
            GRE+ +   + NG      + SQM           K + S + A+   +++ H   G++ 
Sbjct: 2216 GRESPFVKTEDNGSDYLVYLPSQMFEPQKLMINYEKDQKSAEIAS---LTSGHENYGRKE 2272

Query: 150  KKTPEKKTGN---KDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGI------GTE 200
            +     + G+   ++   D+AFLID S  +G   F   K F+  V     I       T 
Sbjct: 2273 EPDHTYEPGDVSLQEYYMDVAFLIDASQRVGSDEFKEVKAFITSVLDYFHIAPTPLTSTL 2332

Query: 201  GPHVGLVQAS---------EHP-KIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKH 250
            G  V ++  S         E P  +EF L  + S   +   +++     G+   G AL+ 
Sbjct: 2333 GDRVAVLSYSPPGYMPNTEECPVYLEFDLVTYNSIHQMKHHLQDSQQLNGDVFIGHALQW 2392

Query: 251  TAQKFFTVDAGVRKGIPKVVVVFIDG----WPSDDIEEAGIVAREFGVNVFIVSVA---- 302
            T    F     +RK   KV+ V   G       D +    + A+  G ++F+ S      
Sbjct: 2393 TIDNVFVGTPNLRKN--KVIFVISAGETNSLDKDVLRNVSLRAKCQGYSIFVFSFGPKHN 2450

Query: 303  -KPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLV 347
             K + E      D   V             H P+W    K+VKP V
Sbjct: 2451 DKELEELASHPLDHHLVQLG--------RTHKPDWNYIIKFVKPFV 2488


>gi|13699836 matrilin 4 isoform 3 precursor [Homo sapiens]
          Length = 499

 Score =  145 bits (367), Expect = 7e-35
 Identities = 108/426 (25%), Positives = 185/426 (43%), Gaps = 64/426 (15%)

Query: 165 DIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTS 224
           D+ F+ID S ++    F   + F+  +   L +G     VG++Q S   +  F L+ F+ 
Sbjct: 34  DLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLRAFSR 93

Query: 225 AKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVR---KGIPKVVVVFIDGWPSDD 281
            +D+  AI+++      + TG A+++     F+V  G R   + +P+V V+  DG P D 
Sbjct: 94  REDMERAIRDLVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGRPQDR 153

Query: 282 IEEAGIVAREFGVNVFIVSVAK------------PIPEELGMVQDVTFVDKAVCRNNGFF 329
           + E    AR  G+ ++ V V +            P+ E + +V+    + +         
Sbjct: 154 VAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEHVFLVESFDLIQE--------- 204

Query: 330 SYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNS------------------------ 365
                  FG     +  V+ LC      C   C +                         
Sbjct: 205 -------FGLQFQSRLCVRDLCNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSCNRC 257

Query: 366 ----VNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSF 421
               V++  L+DGS SV   NF L+  FV+ I    ++S  G ++  VQF+   RTEF  
Sbjct: 258 REGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPL 317

Query: 422 TDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRESPNKNFLV-----IVTDG 476
             Y T   V   +  + YM  GT TG A+   V + F   + +  +   V     + TDG
Sbjct: 318 GRYGTAAEVKQAVLAVEYMERGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDG 377

Query: 477 QSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSD 536
           +S DD+   AA A + GI +++VGV  A   +L+++AS+P E H  +  +F  +  ++ +
Sbjct: 378 RSQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPAELHVSYAPDFGTMTHLLEN 437

Query: 537 VIRGIC 542
           +   IC
Sbjct: 438 LRGSIC 443



 Score = 89.4 bits (220), Expect = 8e-18
 Identities = 54/169 (31%), Positives = 86/169 (50%), Gaps = 3/169 (1%)

Query: 144 PTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPH 203
           P G++L+   +     ++   D+  L+DGS ++  + F L K FV ++   L +  EG  
Sbjct: 242 PEGRQLQADGKSCNRCREGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTR 301

Query: 204 VGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVR 263
           VGLVQ S   + EF L  + +A +V  A+  V +    + TG AL+H  +  F+   G R
Sbjct: 302 VGLVQFSSRVRTEFPLGRYGTAAEVKQAVLAVEYMERGTMTGLALRHMVEHSFSEAQGAR 361

Query: 264 K---GIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEEL 309
                +P+V +VF DG   DDI      A+E G+ ++ V V K +  EL
Sbjct: 362 PRALNVPRVGLVFTDGRSQDDISVWAARAKEEGIVMYAVGVGKAVEAEL 410



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 53/187 (28%), Positives = 88/187 (47%), Gaps = 5/187 (2%)

Query: 346 LVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAK 405
           L+Q   T  Q+   +     +++ F+ID S SV    F  M +F+  + +   +     +
Sbjct: 13  LLQPWETQLQLTGPRCHTGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATR 72

Query: 406 IAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIR--- 462
           +  +Q++   ++ F    +S +E++   IR++  ++ GT TG AI + +   F       
Sbjct: 73  VGVIQYSSQVQSVFPLRAFSRREDMERAIRDLVPLAQGTMTGLAIQYAMNVAFSVAEGAR 132

Query: 463 --ESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESH 520
             E       VIVTDG+  D V   AA A   GI I++VGV  A +  L+ MAS P + H
Sbjct: 133 PPEERVPRVAVIVTDGRPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEH 192

Query: 521 AFFTREF 527
            F    F
Sbjct: 193 VFLVESF 199


>gi|55743106 alpha 3 type VI collagen isoform 5 precursor [Homo
           sapiens]
          Length = 2971

 Score =  140 bits (352), Expect = 4e-33
 Identities = 109/364 (29%), Positives = 176/364 (48%), Gaps = 22/364 (6%)

Query: 164 ADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFT 223
           ADI FLIDGS N G   F +  +F+  +   L IGT+   VG+VQ S+ P+  F L  ++
Sbjct: 35  ADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYS 94

Query: 224 SAKDVLFAIKEVGFRGGN-SNTGKALKHTAQKFFTVDAG--VRKGIPKVVVVFIDGWPSD 280
           +   VL A+K +GF GG  +N G AL    +  FT   G  V +G+P+V+V+   G  SD
Sbjct: 95  TKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSSD 154

Query: 281 DIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYH------MP 334
           +I    +  ++  V  F +        EL   Q +   D  V     F S+       +P
Sbjct: 155 EIRYGVVALKQASVFSFGLGAQAASRAEL---QHIATDDNLVFTVPEFRSFGDLQEKLLP 211

Query: 335 NWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIA 394
              G  +  + +V K  T   ++      N  +I FL+DGSS++G +NF  + +F++ + 
Sbjct: 212 YIVGVAQ--RHIVLKPPT---IVTQVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVI 266

Query: 395 KTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTA-TGDAISFT 453
           +  EI     ++A  Q+    R EF F  + TK  V+  +R ++ + G    TG A+ F 
Sbjct: 267 QRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFV 326

Query: 454 VRNVF----GPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDL 509
             N+F    G          LV++T G+S D++  PA     + I  F++G   A   +L
Sbjct: 327 RNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAEL 386

Query: 510 KDMA 513
           +++A
Sbjct: 387 EEIA 390



 Score =  138 bits (347), Expect = 1e-32
 Identities = 111/387 (28%), Positives = 181/387 (46%), Gaps = 25/387 (6%)

Query: 163 KADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNF 222
           K DI FL+DGS  +G   FN  ++F+ KV   L IG +   V + Q ++  + EFY    
Sbjct: 237 KRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTH 296

Query: 223 TSAKDVLFAIKEVGFRGGNS-NTGKALKHTAQKFFTVDAGVR--KGIPKVVVVFIDGWPS 279
            + ++V+ A++++    G++  TG AL       FT  AG R  +GIPK++V+   G   
Sbjct: 297 PTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSL 356

Query: 280 DDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGT 339
           D+I +     +   +  F +        EL   +++ F    V          +P  F  
Sbjct: 357 DEISQPAQELKRSSIMAFAIGNKGADQAEL---EEIAFDSSLV---------FIPAEFRA 404

Query: 340 TKYVKPLVQKLCTHEQMMCSKTCY-NSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFE 398
                 L   L     +  +   + N  +I FL+DGS++VG +NF  + +FV N+  + +
Sbjct: 405 APLQGMLPGLLAPLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLD 464

Query: 399 ISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSG-GTATGDAISFTVRNV 457
           I +   ++  VQF+    TEFS   Y TK ++L  +R ++   G G  TG A+S+   N 
Sbjct: 465 IGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANH 524

Query: 458 F-----GPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDM 512
           F       IRE      L+++T GQS D     A A   AGI  F VG + A   +L+ +
Sbjct: 525 FTEAGGSRIREHV-PQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQI 583

Query: 513 ASKPKESHAFFTREFTGLEPIVSDVIR 539
           A  P  S  +   +F+ L  +   +I+
Sbjct: 584 AFNP--SLVYLMDDFSSLPALPQQLIQ 608



 Score =  129 bits (325), Expect = 5e-30
 Identities = 106/379 (27%), Positives = 168/379 (44%), Gaps = 12/379 (3%)

Query: 163  KADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNF 222
            K D+ FLIDGS + G   F   +  + ++   L +G +   V ++Q S+ PK+EF L   
Sbjct: 1025 KRDVVFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAH 1083

Query: 223  TSAKDVLFAIKEVGFRGGNS-NTGKALKHTAQKFFTVDAGVR--KGIPKVVVVFIDGWPS 279
            +S  +V  A++ +  +GG   N G AL++ ++  F    G R  +G+P+ +V+   G   
Sbjct: 1084 SSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSD 1143

Query: 280  DDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGT 339
            D++++  +  ++FGV  F ++      EEL  +        +V       S         
Sbjct: 1144 DEVDDPAVELKQFGVAPFTIA-RNADQEELVKISLSPEYVFSVSTFRELPSLEQKLLTPI 1202

Query: 340  TKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEI 399
            T      +QKL    +        ++ +I FLID S  V    F  + +FVS I +   I
Sbjct: 1203 TTLTSEQIQKLLASTRYPPPAVESDAADIVFLIDSSEGVRPDGFAHIRDFVSRIVRRLNI 1262

Query: 400  SDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTA-TGDAISFTVRNVF 458
                 ++  VQF+ D   EF    Y ++  VL  IR +R   G    TG A+ F  RN+F
Sbjct: 1263 GPSKVRVGVVQFSNDVFPEFYLKTYRSQAPVLDAIRRLRLRGGSPLNTGKALEFVARNLF 1322

Query: 459  ----GPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMAS 514
                G   E      LV+V  G+S DDV   A     +GI    VG       +L+ + +
Sbjct: 1323 VKSAGSRIEDGVPQHLVLVLGGKSQDDVSRFAQVIRSSGIVSLGVGDRNIDRTELQTITN 1382

Query: 515  KPKESHAFFTREFTGLEPI 533
             P+    F  REF  L  I
Sbjct: 1383 DPR--LVFTVREFRELPNI 1399



 Score =  127 bits (318), Expect = 3e-29
 Identities = 101/383 (26%), Positives = 180/383 (46%), Gaps = 30/383 (7%)

Query: 147 KRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGL 206
           + L  TPE  +     K DI FL+DGS N+G+  F   ++FV  +   L IG +   VGL
Sbjct: 419 RTLSGTPEVHSN----KRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGL 474

Query: 207 VQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNS-NTGKALKHTAQKFFTVDAG--VR 263
           VQ S+ P  EF L  + +  D+L  ++++  +GG+  NTG AL +     FT   G  +R
Sbjct: 475 VQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIR 534

Query: 264 KGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVC 323
           + +P+++++   G   D   +A       G+  F V  ++    EL   + + F      
Sbjct: 535 EHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAEL---EQIAF------ 585

Query: 324 RNNGFFSYHMPNWFGTTKYVKPLVQKLCTH-----EQMMCSKTCYNSVNIAFLIDGSSSV 378
             N    Y M ++       + L+Q L T+     E++  ++   +  +I FL DGS+++
Sbjct: 586 --NPSLVYLMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQP-ESKRDILFLFDGSANL 642

Query: 379 GDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIR 438
               F ++ +F+  I     +   G +IA  Q++ D + E  F ++ +K  +L +++ ++
Sbjct: 643 -VGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMK 701

Query: 439 YMSGGTAT-GDAISFTVRNVF----GPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAG 493
             +G     G A+ +  R +F    G   E     FLV++  G+S D V GPA+    +G
Sbjct: 702 IKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSG 761

Query: 494 ITIFSVGVAWAPLDDLKDMASKP 516
           +  F      A   +L+ +   P
Sbjct: 762 VVPFIFQAKNADPAELEQIVLSP 784



 Score =  123 bits (308), Expect = 5e-28
 Identities = 104/414 (25%), Positives = 187/414 (45%), Gaps = 34/414 (8%)

Query: 138  VSTAHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGI 197
            +   HP     LK            + D+ FL+DGS  + +  F L K FV +V   L +
Sbjct: 796  IGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDV 854

Query: 198  GTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGG-NSNTGKALKHTAQKFF 256
            G +   V +VQ S+  + EFYL ++ + +DV+ A++++   GG   NTG AL+   +   
Sbjct: 855  GQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNIL 914

Query: 257  TVDAGVR--KGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQD 314
               AG R  +G+P++++V       DD+    +V +  G     + +      ++  +Q 
Sbjct: 915  VSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGN---ADITEMQT 971

Query: 315  VTFVDKAVCRNNGFFSYHMPNW--FGTTKYV-KPLVQKLCTHE--------QMMCSKTCY 363
            ++F+          F+  +P +   GT + V    V +L   E        Q + S    
Sbjct: 972  ISFIPD--------FAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGVG 1023

Query: 364  NSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTD 423
               ++ FLIDGS S G   F+ +   +  +    ++     ++A +QF+ D + EF    
Sbjct: 1024 GKRDVVFLIDGSQSAG-PEFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNA 1082

Query: 424  YSTKENVLAVIRNIRYMSGGTA-TGDAISFTVRNVF----GPIRESPNKNFLVIVTDGQS 478
            +S+K+ V   ++ +R   G     G+A+ +  RN+F    G   E     FLV+++ G+S
Sbjct: 1083 HSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKS 1142

Query: 479  YDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFT-REFTGLE 531
             D+V  PA      G+  F++    A  ++L  ++  P+   +  T RE   LE
Sbjct: 1143 DDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSPEYVFSVSTFRELPSLE 1195



 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 106/420 (25%), Positives = 177/420 (42%), Gaps = 53/420 (12%)

Query: 137  AVSTAHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLG 196
            A + A P         PEKK      KADI FL+DGS N  +  F     FV ++   + 
Sbjct: 1411 AATPAPPGVDTPPPSRPEKK------KADIVFLLDGSINFRRDSFQEVLRFVSEIVDTVY 1464

Query: 197  IGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGG-NSNTGKALKHTAQKF 255
               +   VGLVQ +  P  EF+LK+F++ + ++ AI +V ++GG ++NT   L+H     
Sbjct: 1465 EDGDSIQVGLVQYNSDPTDEFFLKDFSTKRQIIDAINKVVYKGGRHANTKVGLEHLRVNH 1524

Query: 256  FTVDAGVR--KGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQ 313
            F  +AG R  + +P++  V   G   +D ++  +   + GV VF V V     EE+G + 
Sbjct: 1525 FVPEAGSRLDQRVPQIAFVITGGKSVEDAQDVSLALTQRGVKVFAVGVRNIDSEEVGKI- 1583

Query: 314  DVTFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKL--CTHEQMM-----CSKTCYNSV 366
                       +N   ++ + N    ++  + +++ L    HE +       +K C   V
Sbjct: 1584 ----------ASNSATAFRVGNVQELSELSEQVLETLHDAMHETLCPGVTDAAKACNLDV 1633

Query: 367  NIAFLIDGSSS----VGDSNFRLMLEFVSN-IAKTFEISDIGAKIAAVQFTYDQRT---- 417
             + F  DGS      V    F   ++ + N I++   +S  G +   V+ +    T    
Sbjct: 1634 ILGF--DGSRDQNVFVAQKGFESKVDAILNRISQMHRVSCSGGRSPTVRVSVVANTPSGP 1691

Query: 418  --EFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRESPNKNFLVIV-- 473
               F F +Y  +  +L   RN+R       T D    T++      R+S   +  V++  
Sbjct: 1692 VEAFDFDEY--QPEMLEKFRNMRSQHPYVLTED----TLKVYLNKFRQSSPDSVKVVIHF 1745

Query: 474  TDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPI 533
            TDG       G  A  H A   +   GV    L  L+ + +  +  H  F R F    P+
Sbjct: 1746 TDG-----ADGDLADLHRASENLRQEGVRALILVGLERVVNLERLMHLEFGRGFMYDRPL 1800



 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 64/216 (29%), Positives = 102/216 (47%), Gaps = 22/216 (10%)

Query: 345 PLVQKLC--------THEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKT 396
           PLV   C        TH Q    +   +S +I FLIDGS++ G  NF ++L+F+ N+ + 
Sbjct: 8   PLVAVFCLFLSGFPTTHAQQQ--QAAQDSADIIFLIDGSNNTGSVNFAVILDFLVNLLEK 65

Query: 397 FEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTAT-GDAISFTVR 455
             I     ++  VQF+ + RT FS   YSTK  VL  ++ + +  G  A  G A+ F V 
Sbjct: 66  LPIGTQQIRVGVVQFSDEPRTMFSLDTYSTKAQVLGAVKALGFAGGELANIGLALDFVVE 125

Query: 456 NVF----GPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKD 511
           N F    G   E      LV+++ G S D+++    A   A +  F +G   A   +L+ 
Sbjct: 126 NHFTRAGGSRVEEGVPQVLVLISAGPSSDEIRYGVVALKQASVFSFGLGAQAASRAELQH 185

Query: 512 MASKPKESHAFFT----REFTGLEPIVSDVIRGICR 543
           +A+   + +  FT    R F  L+  +   I G+ +
Sbjct: 186 IAT---DDNLVFTVPEFRSFGDLQEKLLPYIVGVAQ 218



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 33/125 (26%), Positives = 61/125 (48%), Gaps = 20/125 (16%)

Query: 366  VNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIG------AKIAAVQFTYDQ---- 415
            +++AF++D + +     F  M ++++ + +  ++S         A++A VQ    +    
Sbjct: 2412 IDMAFILDSAETTTLFQFNEMKKYIAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDN 2471

Query: 416  ------RTEFSFTDYSTKENVLAVI-RNIRYMSGGTATGDAISFTVRNVFGPIRESPNKN 468
                  + EFS TDY +KE ++  + R +  + G  A G AI +T+ NVF     +PN  
Sbjct: 2472 ASMPPVKVEFSLTDYGSKEKLVDFLSRGMTQLQGTRALGSAIEYTIENVF---ESAPNPR 2528

Query: 469  FLVIV 473
             L IV
Sbjct: 2529 DLKIV 2533



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 30/101 (29%), Positives = 47/101 (46%), Gaps = 6/101 (5%)

Query: 368  IAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDI----GAKIAAVQFTYDQRTEFSFTD 423
            +AF +D S  V    F  M + V +I     I++     GA++A V +  +  TE  F D
Sbjct: 2197 LAFALDTSEGVNQDTFGRMRDVVLSIVNDLTIAESNCPRGARVAVVTYNNEVTTEIRFAD 2256

Query: 424  YSTKENVLAVIRNIR--YMSGGTATGDAISFTVRNVFGPIR 462
               K  +L  I+N++    S   +   A+SF  RN F  +R
Sbjct: 2257 SKRKSVLLDKIKNLQVALTSKQQSLETAMSFVARNTFKRVR 2297



 Score = 33.5 bits (75), Expect = 0.52
 Identities = 32/150 (21%), Positives = 62/150 (41%), Gaps = 20/150 (13%)

Query: 154  EKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTE---GPHVGLVQAS 210
            +++    D   D+AF++D +      +FN  K ++  +   L +  +     H   V   
Sbjct: 2402 DRRAAGSDVDIDMAFILDSAETTTLFQFNEMKKYIAYLVRQLDMSPDPKASQHFARVAVV 2461

Query: 211  EHP-------------KIEFYLKNFTSAKDVL-FAIKEVGFRGGNSNTGKALKHTAQKFF 256
            +H              K+EF L ++ S + ++ F  + +    G    G A+++T +  F
Sbjct: 2462 QHAPSESVDNASMPPVKVEFSLTDYGSKEKLVDFLSRGMTQLQGTRALGSAIEYTIENVF 2521

Query: 257  TVDAGVRKGIPKVVVVFIDG-WPSDDIEEA 285
                  R    K+VV+ + G  P   +EEA
Sbjct: 2522 ESAPNPRD--LKIVVLMLTGEVPEQQLEEA 2549


>gi|240255540 alpha 3 type VI collagen isoform 3 precursor [Homo
           sapiens]
          Length = 1237

 Score =  140 bits (352), Expect = 4e-33
 Identities = 109/364 (29%), Positives = 176/364 (48%), Gaps = 22/364 (6%)

Query: 164 ADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFT 223
           ADI FLIDGS N G   F +  +F+  +   L IGT+   VG+VQ S+ P+  F L  ++
Sbjct: 35  ADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYS 94

Query: 224 SAKDVLFAIKEVGFRGGN-SNTGKALKHTAQKFFTVDAG--VRKGIPKVVVVFIDGWPSD 280
           +   VL A+K +GF GG  +N G AL    +  FT   G  V +G+P+V+V+   G  SD
Sbjct: 95  TKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSSD 154

Query: 281 DIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYH------MP 334
           +I    +  ++  V  F +        EL   Q +   D  V     F S+       +P
Sbjct: 155 EIRYGVVALKQASVFSFGLGAQAASRAEL---QHIATDDNLVFTVPEFRSFGDLQEKLLP 211

Query: 335 NWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIA 394
              G  +  + +V K  T   ++      N  +I FL+DGSS++G +NF  + +F++ + 
Sbjct: 212 YIVGVAQ--RHIVLKPPT---IVTQVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVI 266

Query: 395 KTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTA-TGDAISFT 453
           +  EI     ++A  Q+    R EF F  + TK  V+  +R ++ + G    TG A+ F 
Sbjct: 267 QRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFV 326

Query: 454 VRNVF----GPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDL 509
             N+F    G          LV++T G+S D++  PA     + I  F++G   A   +L
Sbjct: 327 RNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAEL 386

Query: 510 KDMA 513
           +++A
Sbjct: 387 EEIA 390



 Score =  138 bits (347), Expect = 1e-32
 Identities = 111/387 (28%), Positives = 181/387 (46%), Gaps = 25/387 (6%)

Query: 163 KADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNF 222
           K DI FL+DGS  +G   FN  ++F+ KV   L IG +   V + Q ++  + EFY    
Sbjct: 237 KRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTH 296

Query: 223 TSAKDVLFAIKEVGFRGGNS-NTGKALKHTAQKFFTVDAGVR--KGIPKVVVVFIDGWPS 279
            + ++V+ A++++    G++  TG AL       FT  AG R  +GIPK++V+   G   
Sbjct: 297 PTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSL 356

Query: 280 DDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGT 339
           D+I +     +   +  F +        EL   +++ F    V          +P  F  
Sbjct: 357 DEISQPAQELKRSSIMAFAIGNKGADQAEL---EEIAFDSSLV---------FIPAEFRA 404

Query: 340 TKYVKPLVQKLCTHEQMMCSKTCY-NSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFE 398
                 L   L     +  +   + N  +I FL+DGS++VG +NF  + +FV N+  + +
Sbjct: 405 APLQGMLPGLLAPLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLD 464

Query: 399 ISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSG-GTATGDAISFTVRNV 457
           I +   ++  VQF+    TEFS   Y TK ++L  +R ++   G G  TG A+S+   N 
Sbjct: 465 IGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANH 524

Query: 458 F-----GPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDM 512
           F       IRE      L+++T GQS D     A A   AGI  F VG + A   +L+ +
Sbjct: 525 FTEAGGSRIREHV-PQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQI 583

Query: 513 ASKPKESHAFFTREFTGLEPIVSDVIR 539
           A  P  S  +   +F+ L  +   +I+
Sbjct: 584 AFNP--SLVYLMDDFSSLPALPQQLIQ 608



 Score =  127 bits (318), Expect = 3e-29
 Identities = 101/383 (26%), Positives = 180/383 (46%), Gaps = 30/383 (7%)

Query: 147 KRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGL 206
           + L  TPE  +     K DI FL+DGS N+G+  F   ++FV  +   L IG +   VGL
Sbjct: 419 RTLSGTPEVHSN----KRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGL 474

Query: 207 VQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNS-NTGKALKHTAQKFFTVDAG--VR 263
           VQ S+ P  EF L  + +  D+L  ++++  +GG+  NTG AL +     FT   G  +R
Sbjct: 475 VQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIR 534

Query: 264 KGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVC 323
           + +P+++++   G   D   +A       G+  F V  ++    EL   + + F      
Sbjct: 535 EHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAEL---EQIAF------ 585

Query: 324 RNNGFFSYHMPNWFGTTKYVKPLVQKLCTH-----EQMMCSKTCYNSVNIAFLIDGSSSV 378
             N    Y M ++       + L+Q L T+     E++  ++   +  +I FL DGS+++
Sbjct: 586 --NPSLVYLMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQP-ESKRDILFLFDGSANL 642

Query: 379 GDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIR 438
               F ++ +F+  I     +   G +IA  Q++ D + E  F ++ +K  +L +++ ++
Sbjct: 643 -VGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMK 701

Query: 439 YMSGGTAT-GDAISFTVRNVF----GPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAG 493
             +G     G A+ +  R +F    G   E     FLV++  G+S D V GPA+    +G
Sbjct: 702 IKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSG 761

Query: 494 ITIFSVGVAWAPLDDLKDMASKP 516
           +  F      A   +L+ +   P
Sbjct: 762 VVPFIFQAKNADPAELEQIVLSP 784



 Score =  123 bits (308), Expect = 5e-28
 Identities = 104/414 (25%), Positives = 187/414 (45%), Gaps = 34/414 (8%)

Query: 138  VSTAHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGI 197
            +   HP     LK            + D+ FL+DGS  + +  F L K FV +V   L +
Sbjct: 796  IGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDV 854

Query: 198  GTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGG-NSNTGKALKHTAQKFF 256
            G +   V +VQ S+  + EFYL ++ + +DV+ A++++   GG   NTG AL+   +   
Sbjct: 855  GQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNIL 914

Query: 257  TVDAGVR--KGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQD 314
               AG R  +G+P++++V       DD+    +V +  G     + +      ++  +Q 
Sbjct: 915  VSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGN---ADITEMQT 971

Query: 315  VTFVDKAVCRNNGFFSYHMPNW--FGTTKYV-KPLVQKLCTHE--------QMMCSKTCY 363
            ++F+          F+  +P +   GT + V    V +L   E        Q + S    
Sbjct: 972  ISFIPD--------FAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGVG 1023

Query: 364  NSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTD 423
               ++ FLIDGS S G   F+ +   +  +    ++     ++A +QF+ D + EF    
Sbjct: 1024 GKRDVVFLIDGSQSAG-PEFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNA 1082

Query: 424  YSTKENVLAVIRNIRYMSGGTA-TGDAISFTVRNVF----GPIRESPNKNFLVIVTDGQS 478
            +S+K+ V   ++ +R   G     G+A+ +  RN+F    G   E     FLV+++ G+S
Sbjct: 1083 HSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKS 1142

Query: 479  YDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFT-REFTGLE 531
             D+V  PA      G+  F++    A  ++L  ++  P+   +  T RE   LE
Sbjct: 1143 DDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSPEYVFSVSTFRELPSLE 1195



 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 64/216 (29%), Positives = 102/216 (47%), Gaps = 22/216 (10%)

Query: 345 PLVQKLC--------THEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKT 396
           PLV   C        TH Q    +   +S +I FLIDGS++ G  NF ++L+F+ N+ + 
Sbjct: 8   PLVAVFCLFLSGFPTTHAQQQ--QAAQDSADIIFLIDGSNNTGSVNFAVILDFLVNLLEK 65

Query: 397 FEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTAT-GDAISFTVR 455
             I     ++  VQF+ + RT FS   YSTK  VL  ++ + +  G  A  G A+ F V 
Sbjct: 66  LPIGTQQIRVGVVQFSDEPRTMFSLDTYSTKAQVLGAVKALGFAGGELANIGLALDFVVE 125

Query: 456 NVF----GPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKD 511
           N F    G   E      LV+++ G S D+++    A   A +  F +G   A   +L+ 
Sbjct: 126 NHFTRAGGSRVEEGVPQVLVLISAGPSSDEIRYGVVALKQASVFSFGLGAQAASRAELQH 185

Query: 512 MASKPKESHAFFT----REFTGLEPIVSDVIRGICR 543
           +A+   + +  FT    R F  L+  +   I G+ +
Sbjct: 186 IAT---DDNLVFTVPEFRSFGDLQEKLLPYIVGVAQ 218


>gi|240255542 alpha 3 type VI collagen isoform 2 precursor [Homo
           sapiens]
          Length = 1036

 Score =  138 bits (347), Expect = 1e-32
 Identities = 111/387 (28%), Positives = 181/387 (46%), Gaps = 25/387 (6%)

Query: 163 KADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNF 222
           K DI FL+DGS  +G   FN  ++F+ KV   L IG +   V + Q ++  + EFY    
Sbjct: 36  KRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTH 95

Query: 223 TSAKDVLFAIKEVGFRGGNS-NTGKALKHTAQKFFTVDAGVR--KGIPKVVVVFIDGWPS 279
            + ++V+ A++++    G++  TG AL       FT  AG R  +GIPK++V+   G   
Sbjct: 96  PTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSL 155

Query: 280 DDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGT 339
           D+I +     +   +  F +        EL   +++ F    V          +P  F  
Sbjct: 156 DEISQPAQELKRSSIMAFAIGNKGADQAEL---EEIAFDSSLV---------FIPAEFRA 203

Query: 340 TKYVKPLVQKLCTHEQMMCSKTCY-NSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFE 398
                 L   L     +  +   + N  +I FL+DGS++VG +NF  + +FV N+  + +
Sbjct: 204 APLQGMLPGLLAPLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLD 263

Query: 399 ISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSG-GTATGDAISFTVRNV 457
           I +   ++  VQF+    TEFS   Y TK ++L  +R ++   G G  TG A+S+   N 
Sbjct: 264 IGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANH 323

Query: 458 F-----GPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDM 512
           F       IRE      L+++T GQS D     A A   AGI  F VG + A   +L+ +
Sbjct: 324 FTEAGGSRIREHV-PQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQI 382

Query: 513 ASKPKESHAFFTREFTGLEPIVSDVIR 539
           A  P  S  +   +F+ L  +   +I+
Sbjct: 383 AFNP--SLVYLMDDFSSLPALPQQLIQ 407



 Score =  127 bits (318), Expect = 3e-29
 Identities = 101/383 (26%), Positives = 180/383 (46%), Gaps = 30/383 (7%)

Query: 147 KRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGL 206
           + L  TPE  +     K DI FL+DGS N+G+  F   ++FV  +   L IG +   VGL
Sbjct: 218 RTLSGTPEVHSN----KRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGL 273

Query: 207 VQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNS-NTGKALKHTAQKFFTVDAG--VR 263
           VQ S+ P  EF L  + +  D+L  ++++  +GG+  NTG AL +     FT   G  +R
Sbjct: 274 VQFSDTPVTEFSLNTYQTKSDILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIR 333

Query: 264 KGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVC 323
           + +P+++++   G   D   +A       G+  F V  ++    EL   + + F      
Sbjct: 334 EHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAEL---EQIAF------ 384

Query: 324 RNNGFFSYHMPNWFGTTKYVKPLVQKLCTH-----EQMMCSKTCYNSVNIAFLIDGSSSV 378
             N    Y M ++       + L+Q L T+     E++  ++   +  +I FL DGS+++
Sbjct: 385 --NPSLVYLMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQP-ESKRDILFLFDGSANL 441

Query: 379 GDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIR 438
               F ++ +F+  I     +   G +IA  Q++ D + E  F ++ +K  +L +++ ++
Sbjct: 442 -VGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMK 500

Query: 439 YMSGGTAT-GDAISFTVRNVF----GPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAG 493
             +G     G A+ +  R +F    G   E     FLV++  G+S D V GPA+    +G
Sbjct: 501 IKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSG 560

Query: 494 ITIFSVGVAWAPLDDLKDMASKP 516
           +  F      A   +L+ +   P
Sbjct: 561 VVPFIFQAKNADPAELEQIVLSP 583



 Score =  123 bits (308), Expect = 5e-28
 Identities = 104/414 (25%), Positives = 187/414 (45%), Gaps = 34/414 (8%)

Query: 138 VSTAHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGI 197
           +   HP     LK            + D+ FL+DGS  + +  F L K FV +V   L +
Sbjct: 595 IGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDV 653

Query: 198 GTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGG-NSNTGKALKHTAQKFF 256
           G +   V +VQ S+  + EFYL ++ + +DV+ A++++   GG   NTG AL+   +   
Sbjct: 654 GQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNIL 713

Query: 257 TVDAGVR--KGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQD 314
              AG R  +G+P++++V       DD+    +V +  G     + +      ++  +Q 
Sbjct: 714 VSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGN---ADITEMQT 770

Query: 315 VTFVDKAVCRNNGFFSYHMPNW--FGTTKYV-KPLVQKLCTHE--------QMMCSKTCY 363
           ++F+          F+  +P +   GT + V    V +L   E        Q + S    
Sbjct: 771 ISFIPD--------FAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGVG 822

Query: 364 NSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTD 423
              ++ FLIDGS S G   F+ +   +  +    ++     ++A +QF+ D + EF    
Sbjct: 823 GKRDVVFLIDGSQSAG-PEFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNA 881

Query: 424 YSTKENVLAVIRNIRYMSGGTA-TGDAISFTVRNVF----GPIRESPNKNFLVIVTDGQS 478
           +S+K+ V   ++ +R   G     G+A+ +  RN+F    G   E     FLV+++ G+S
Sbjct: 882 HSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKS 941

Query: 479 YDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFT-REFTGLE 531
            D+V  PA      G+  F++    A  ++L  ++  P+   +  T RE   LE
Sbjct: 942 DDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSPEYVFSVSTFRELPSLE 994



 Score = 83.6 bits (205), Expect = 4e-16
 Identities = 53/182 (29%), Positives = 88/182 (48%), Gaps = 13/182 (7%)

Query: 345 PLVQKLC--------THEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKT 396
           PLV   C        TH Q   +    N  +I FL+DGSS++G +NF  + +F++ + + 
Sbjct: 8   PLVAVFCLFLSGFPTTHAQQQQAVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQR 67

Query: 397 FEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTA-TGDAISFTVR 455
            EI     ++A  Q+    R EF F  + TK  V+  +R ++ + G    TG A+ F   
Sbjct: 68  LEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRN 127

Query: 456 NVF----GPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKD 511
           N+F    G          LV++T G+S D++  PA     + I  F++G   A   +L++
Sbjct: 128 NLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEE 187

Query: 512 MA 513
           +A
Sbjct: 188 IA 189


>gi|93141047 collagen, type XII, alpha 1 long isoform precursor
           [Homo sapiens]
          Length = 3063

 Score =  132 bits (332), Expect = 8e-31
 Identities = 71/209 (33%), Positives = 116/209 (55%), Gaps = 10/209 (4%)

Query: 339 TTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFE 398
           T    KP+ +K    E   CS + +   ++ FL+DGS SVG +NF+ +L+F++ +   F+
Sbjct: 114 TGSSTKPVEKKPGKTEIQKCSVSAWT--DLVFLVDGSWSVGRNNFKYILDFIAALVSAFD 171

Query: 399 ISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVF 458
           I +   ++  VQ++ D RTEF+   Y  ++ +LA I+ I Y  G T TGDAI + V+N F
Sbjct: 172 IGEEKTRVGVVQYSSDTRTEFNLNQYYQRDELLAAIKKIPYKGGNTMTGDAIDYLVKNTF 231

Query: 459 GPIRESPN-----KNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMA 513
               ES           +I+TDG+S D+V+ PA    + G+ +FS+G+  A   +LK +A
Sbjct: 232 ---TESAGARVGFPKVAIIITDGKSQDEVEIPARELRNVGVEVFSLGIKAADAKELKQIA 288

Query: 514 SKPKESHAFFTREFTGLEPIVSDVIRGIC 542
           S P  +H F    F  +  I +++I  +C
Sbjct: 289 STPSLNHVFNVANFDAIVDIQNEIISQVC 317



 Score =  117 bits (293), Expect = 3e-26
 Identities = 66/180 (36%), Positives = 103/180 (57%), Gaps = 5/180 (2%)

Query: 367  NIAFLIDGSSSVGDSNFRLMLEFVSNIAKTF-EISDIGAKIAAVQFTYDQRTEFSFTDYS 425
            +I FL D S S+GD NF  +++F+ N    F EIS  G +++ VQ++ + ++EF    Y+
Sbjct: 2323 DIVFLTDASWSIGDDNFNKVVKFIFNTVGGFDEISPAGIQVSFVQYSDEVKSEFKLNTYN 2382

Query: 426  TKENVLAVIRNIRYMSGGTATGDAISFTVRNVF---GPIRESPNKNFLVIVTDGQSYDDV 482
             K   L  ++NIRY  G T TG A++F    V      +R++  K  LV+VTDG+S D+V
Sbjct: 2383 DKALALGALQNIRYRGGNTRTGKALTFIKEKVLTWESGMRKNVPK-VLVVVTDGRSQDEV 2441

Query: 483  QGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRGIC 542
            +  A     +G ++F VGVA    ++L ++ASKP E H F   +F   E I  ++I  +C
Sbjct: 2442 KKAALVIQQSGFSVFVVGVADVDYNELANIASKPSERHVFIVDDFESFEKIEDNLITFVC 2501



 Score =  115 bits (287), Expect = 1e-25
 Identities = 61/190 (32%), Positives = 106/190 (55%), Gaps = 2/190 (1%)

Query: 355 QMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYD 414
           Q+ CS+      +I FL+DGS S+G +NF  +  F+  + K+FEIS    +I+ VQ++ D
Sbjct: 428 QVECSRGVDIKADIVFLVDGSYSIGIANFVKVRAFLEVLVKSFEISPNRVQISLVQYSRD 487

Query: 415 QRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRESPNK--NFLVI 472
             TEF+   ++  E+++  I    Y  G T TG A+++    +F P + S +     +++
Sbjct: 488 PHTEFTLKKFTKVEDIIEAINTFPYRGGSTNTGKAMTYVREKIFVPSKGSRSNVPKVMIL 547

Query: 473 VTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEP 532
           +TDG+S D  + PA    ++ + IF+VGV  A   +L+ +AS P E+H F   +F   + 
Sbjct: 548 ITDGKSSDAFRDPAIKLRNSDVEIFAVGVKDAVRSELEAIASPPAETHVFTVEDFDAFQR 607

Query: 533 IVSDVIRGIC 542
           I  ++ + IC
Sbjct: 608 ISFELTQSIC 617



 Score =  113 bits (283), Expect = 4e-25
 Identities = 61/179 (34%), Positives = 102/179 (56%), Gaps = 4/179 (2%)

Query: 367  NIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYST 426
            +I  L+DGS S+G +NFR +  F+S I + F+I     +IA  Q++ D RTE+    +  
Sbjct: 1199 DIVLLVDGSWSIGRANFRTVRSFISRIVEVFDIGPKRVQIALAQYSGDPRTEWQLNAHRD 1258

Query: 427  KENVLAVIRNIRYMSGGTATGDAISFTVRNVF---GPIRESPNKNFLVIVTDGQSYDDVQ 483
            K+++L  + N+ Y  G T TG A++F  +  F     +R    K   V++TDG+S DDV+
Sbjct: 1259 KKSLLQAVANLPYKGGNTLTGMALNFIRQQNFRTQAGMRPRARK-IGVLITDGKSQDDVE 1317

Query: 484  GPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRGIC 542
             P+    D G+ +F++G+  A   +LK +A+ P ++HA+   +F  L  IV D+   +C
Sbjct: 1318 APSKKLKDEGVELFAIGIKNADEVELKMIATDPDDTHAYNVADFESLSRIVDDLTINLC 1376



 Score =  105 bits (263), Expect = 8e-23
 Identities = 56/149 (37%), Positives = 79/149 (53%)

Query: 161 DCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLK 220
           D KADI FL+DGS++IG   F   + F+  +     I      + LVQ S  P  EF LK
Sbjct: 436 DIKADIVFLVDGSYSIGIANFVKVRAFLEVLVKSFEISPNRVQISLVQYSRDPHTEFTLK 495

Query: 221 NFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSD 280
            FT  +D++ AI    +RGG++NTGKA+ +  +K F    G R  +PKV+++  DG  SD
Sbjct: 496 KFTKVEDIIEAINTFPYRGGSTNTGKAMTYVREKIFVPSKGSRSNVPKVMILITDGKSSD 555

Query: 281 DIEEAGIVAREFGVNVFIVSVAKPIPEEL 309
              +  I  R   V +F V V   +  EL
Sbjct: 556 AFRDPAIKLRNSDVEIFAVGVKDAVRSEL 584



 Score =  105 bits (262), Expect = 1e-22
 Identities = 63/171 (36%), Positives = 90/171 (52%), Gaps = 1/171 (0%)

Query: 143  PPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFV-GKVALMLGIGTEG 201
            PPT       P  +   K  KADI FL D S++IG   FN    F+   V     I   G
Sbjct: 2301 PPTPPPPPTIPPARDVCKGAKADIVFLTDASWSIGDDNFNKVVKFIFNTVGGFDEISPAG 2360

Query: 202  PHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAG 261
              V  VQ S+  K EF L  +      L A++ + +RGGN+ TGKAL    +K  T ++G
Sbjct: 2361 IQVSFVQYSDEVKSEFKLNTYNDKALALGALQNIRYRGGNTRTGKALTFIKEKVLTWESG 2420

Query: 262  VRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMV 312
            +RK +PKV+VV  DG   D++++A +V ++ G +VF+V VA     EL  +
Sbjct: 2421 MRKNVPKVLVVVTDGRSQDEVKKAALVIQQSGFSVFVVGVADVDYNELANI 2471



 Score =  102 bits (254), Expect = 9e-22
 Identities = 55/169 (32%), Positives = 87/169 (51%), Gaps = 7/169 (4%)

Query: 151 KTPEKKTGNKDCK-------ADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPH 203
           K  EKK G  + +        D+ FL+DGS+++G+  F    +F+  +     IG E   
Sbjct: 119 KPVEKKPGKTEIQKCSVSAWTDLVFLVDGSWSVGRNNFKYILDFIAALVSAFDIGEEKTR 178

Query: 204 VGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVR 263
           VG+VQ S   + EF L  +    ++L AIK++ ++GGN+ TG A+ +  +  FT  AG R
Sbjct: 179 VGVVQYSSDTRTEFNLNQYYQRDELLAAIKKIPYKGGNTMTGDAIDYLVKNTFTESAGAR 238

Query: 264 KGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMV 312
            G PKV ++  DG   D++E      R  GV VF + +     +EL  +
Sbjct: 239 VGFPKVAIIITDGKSQDEVEIPARELRNVGVEVFSLGIKAADAKELKQI 287



 Score = 89.7 bits (221), Expect = 6e-18
 Identities = 47/150 (31%), Positives = 79/150 (52%)

Query: 163  KADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNF 222
            +ADI  L+DGS++IG+  F   ++F+ ++  +  IG +   + L Q S  P+ E+ L   
Sbjct: 1197 EADIVLLVDGSWSIGRANFRTVRSFISRIVEVFDIGPKRVQIALAQYSGDPRTEWQLNAH 1256

Query: 223  TSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDDI 282
               K +L A+  + ++GGN+ TG AL    Q+ F   AG+R    K+ V+  DG   DD+
Sbjct: 1257 RDKKSLLQAVANLPYKGGNTLTGMALNFIRQQNFRTQAGMRPRARKIGVLITDGKSQDDV 1316

Query: 283  EEAGIVAREFGVNVFIVSVAKPIPEELGMV 312
            E      ++ GV +F + +      EL M+
Sbjct: 1317 EAPSKKLKDEGVELFAIGIKNADEVELKMI 1346


>gi|240255535 alpha 3 type VI collagen isoform 4 precursor [Homo
           sapiens]
          Length = 2570

 Score =  129 bits (325), Expect = 5e-30
 Identities = 106/379 (27%), Positives = 168/379 (44%), Gaps = 12/379 (3%)

Query: 163 KADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNF 222
           K D+ FLIDGS + G   F   +  + ++   L +G +   V ++Q S+ PK+EF L   
Sbjct: 624 KRDVVFLIDGSQSAGPE-FQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAH 682

Query: 223 TSAKDVLFAIKEVGFRGGNS-NTGKALKHTAQKFFTVDAGVR--KGIPKVVVVFIDGWPS 279
           +S  +V  A++ +  +GG   N G AL++ ++  F    G R  +G+P+ +V+   G   
Sbjct: 683 SSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSD 742

Query: 280 DDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGT 339
           D++++  +  ++FGV  F ++      EEL  +        +V       S         
Sbjct: 743 DEVDDPAVELKQFGVAPFTIA-RNADQEELVKISLSPEYVFSVSTFRELPSLEQKLLTPI 801

Query: 340 TKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEI 399
           T      +QKL    +        ++ +I FLID S  V    F  + +FVS I +   I
Sbjct: 802 TTLTSEQIQKLLASTRYPPPAVESDAADIVFLIDSSEGVRPDGFAHIRDFVSRIVRRLNI 861

Query: 400 SDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTA-TGDAISFTVRNVF 458
                ++  VQF+ D   EF    Y ++  VL  IR +R   G    TG A+ F  RN+F
Sbjct: 862 GPSKVRVGVVQFSNDVFPEFYLKTYRSQAPVLDAIRRLRLRGGSPLNTGKALEFVARNLF 921

Query: 459 ----GPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMAS 514
               G   E      LV+V  G+S DDV   A     +GI    VG       +L+ + +
Sbjct: 922 VKSAGSRIEDGVPQHLVLVLGGKSQDDVSRFAQVIRSSGIVSLGVGDRNIDRTELQTITN 981

Query: 515 KPKESHAFFTREFTGLEPI 533
            P+    F  REF  L  I
Sbjct: 982 DPR--LVFTVREFRELPNI 998



 Score =  123 bits (308), Expect = 5e-28
 Identities = 104/414 (25%), Positives = 187/414 (45%), Gaps = 34/414 (8%)

Query: 138 VSTAHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGI 197
           +   HP     LK            + D+ FL+DGS  + +  F L K FV +V   L +
Sbjct: 395 IGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGV-RSGFPLLKEFVQRVVESLDV 453

Query: 198 GTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGG-NSNTGKALKHTAQKFF 256
           G +   V +VQ S+  + EFYL ++ + +DV+ A++++   GG   NTG AL+   +   
Sbjct: 454 GQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNIL 513

Query: 257 TVDAGVR--KGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQD 314
              AG R  +G+P++++V       DD+    +V +  G     + +      ++  +Q 
Sbjct: 514 VSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGN---ADITEMQT 570

Query: 315 VTFVDKAVCRNNGFFSYHMPNW--FGTTKYV-KPLVQKLCTHE--------QMMCSKTCY 363
           ++F+          F+  +P +   GT + V    V +L   E        Q + S    
Sbjct: 571 ISFIPD--------FAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGVG 622

Query: 364 NSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTD 423
              ++ FLIDGS S G   F+ +   +  +    ++     ++A +QF+ D + EF    
Sbjct: 623 GKRDVVFLIDGSQSAG-PEFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNA 681

Query: 424 YSTKENVLAVIRNIRYMSGGTA-TGDAISFTVRNVF----GPIRESPNKNFLVIVTDGQS 478
           +S+K+ V   ++ +R   G     G+A+ +  RN+F    G   E     FLV+++ G+S
Sbjct: 682 HSSKDEVQNAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKS 741

Query: 479 YDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFT-REFTGLE 531
            D+V  PA      G+  F++    A  ++L  ++  P+   +  T RE   LE
Sbjct: 742 DDEVDDPAVELKQFGVAPFTI-ARNADQEELVKISLSPEYVFSVSTFRELPSLE 794



 Score =  108 bits (270), Expect = 1e-23
 Identities = 90/362 (24%), Positives = 165/362 (45%), Gaps = 22/362 (6%)

Query: 163 KADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNF 222
           K DI FL+DGS  +G   FN  ++F+ KV   L IG +   V + Q ++  + EFY    
Sbjct: 36  KRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTH 95

Query: 223 TSAKDVLFAIKEVGFRGGNS-NTGKALKHTAQKFFTVDAGVR--KGIPKVVVVFIDGWPS 279
            + ++V+ A++++    G++  TG AL       FT  AG R  +GIPK++V+   G   
Sbjct: 96  PTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSL 155

Query: 280 DDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGT 339
           D+I +     +   +  F +        EL   +++ F    V          +P  F  
Sbjct: 156 DEISQPAQELKRSSIMAFAIGNKGADQAEL---EEIAFDSSLV---------FIPAEFRA 203

Query: 340 TKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEI 399
              ++ ++  L    + +      +  +I FL DGS+++    F ++ +F+  I     +
Sbjct: 204 AP-LQGMLPGLLAPLRTLSGTPEESKRDILFLFDGSANL-VGQFPVVRDFLYKIIDELNV 261

Query: 400 SDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTAT-GDAISFTVRNVF 458
              G +IA  Q++ D + E  F ++ +K  +L +++ ++  +G     G A+ +  R +F
Sbjct: 262 KPEGTRIAVAQYSDDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIF 321

Query: 459 ----GPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMAS 514
               G   E     FLV++  G+S D V GPA+    +G+  F      A   +L+ +  
Sbjct: 322 VKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVL 381

Query: 515 KP 516
            P
Sbjct: 382 SP 383



 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 106/420 (25%), Positives = 177/420 (42%), Gaps = 53/420 (12%)

Query: 137  AVSTAHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLG 196
            A + A P         PEKK      KADI FL+DGS N  +  F     FV ++   + 
Sbjct: 1010 AATPAPPGVDTPPPSRPEKK------KADIVFLLDGSINFRRDSFQEVLRFVSEIVDTVY 1063

Query: 197  IGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGG-NSNTGKALKHTAQKF 255
               +   VGLVQ +  P  EF+LK+F++ + ++ AI +V ++GG ++NT   L+H     
Sbjct: 1064 EDGDSIQVGLVQYNSDPTDEFFLKDFSTKRQIIDAINKVVYKGGRHANTKVGLEHLRVNH 1123

Query: 256  FTVDAGVR--KGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQ 313
            F  +AG R  + +P++  V   G   +D ++  +   + GV VF V V     EE+G + 
Sbjct: 1124 FVPEAGSRLDQRVPQIAFVITGGKSVEDAQDVSLALTQRGVKVFAVGVRNIDSEEVGKI- 1182

Query: 314  DVTFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKL--CTHEQMM-----CSKTCYNSV 366
                       +N   ++ + N    ++  + +++ L    HE +       +K C   V
Sbjct: 1183 ----------ASNSATAFRVGNVQELSELSEQVLETLHDAMHETLCPGVTDAAKACNLDV 1232

Query: 367  NIAFLIDGSSS----VGDSNFRLMLEFVSN-IAKTFEISDIGAKIAAVQFTYDQRT---- 417
             + F  DGS      V    F   ++ + N I++   +S  G +   V+ +    T    
Sbjct: 1233 ILGF--DGSRDQNVFVAQKGFESKVDAILNRISQMHRVSCSGGRSPTVRVSVVANTPSGP 1290

Query: 418  --EFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRESPNKNFLVIV-- 473
               F F +Y  +  +L   RN+R       T D    T++      R+S   +  V++  
Sbjct: 1291 VEAFDFDEY--QPEMLEKFRNMRSQHPYVLTED----TLKVYLNKFRQSSPDSVKVVIHF 1344

Query: 474  TDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPI 533
            TDG       G  A  H A   +   GV    L  L+ + +  +  H  F R F    P+
Sbjct: 1345 TDG-----ADGDLADLHRASENLRQEGVRALILVGLERVVNLERLMHLEFGRGFMYDRPL 1399



 Score = 83.6 bits (205), Expect = 4e-16
 Identities = 53/182 (29%), Positives = 88/182 (48%), Gaps = 13/182 (7%)

Query: 345 PLVQKLC--------THEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKT 396
           PLV   C        TH Q   +    N  +I FL+DGSS++G +NF  + +F++ + + 
Sbjct: 8   PLVAVFCLFLSGFPTTHAQQQQAVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQR 67

Query: 397 FEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTA-TGDAISFTVR 455
            EI     ++A  Q+    R EF F  + TK  V+  +R ++ + G    TG A+ F   
Sbjct: 68  LEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRN 127

Query: 456 NVF----GPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKD 511
           N+F    G          LV++T G+S D++  PA     + I  F++G   A   +L++
Sbjct: 128 NLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEE 187

Query: 512 MA 513
           +A
Sbjct: 188 IA 189



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 33/125 (26%), Positives = 61/125 (48%), Gaps = 20/125 (16%)

Query: 366  VNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIG------AKIAAVQFTYDQ---- 415
            +++AF++D + +     F  M ++++ + +  ++S         A++A VQ    +    
Sbjct: 2011 IDMAFILDSAETTTLFQFNEMKKYIAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDN 2070

Query: 416  ------RTEFSFTDYSTKENVLAVI-RNIRYMSGGTATGDAISFTVRNVFGPIRESPNKN 468
                  + EFS TDY +KE ++  + R +  + G  A G AI +T+ NVF     +PN  
Sbjct: 2071 ASMPPVKVEFSLTDYGSKEKLVDFLSRGMTQLQGTRALGSAIEYTIENVF---ESAPNPR 2127

Query: 469  FLVIV 473
             L IV
Sbjct: 2128 DLKIV 2132



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 30/101 (29%), Positives = 47/101 (46%), Gaps = 6/101 (5%)

Query: 368  IAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDI----GAKIAAVQFTYDQRTEFSFTD 423
            +AF +D S  V    F  M + V +I     I++     GA++A V +  +  TE  F D
Sbjct: 1796 LAFALDTSEGVNQDTFGRMRDVVLSIVNDLTIAESNCPRGARVAVVTYNNEVTTEIRFAD 1855

Query: 424  YSTKENVLAVIRNIR--YMSGGTATGDAISFTVRNVFGPIR 462
               K  +L  I+N++    S   +   A+SF  RN F  +R
Sbjct: 1856 SKRKSVLLDKIKNLQVALTSKQQSLETAMSFVARNTFKRVR 1896



 Score = 33.5 bits (75), Expect = 0.52
 Identities = 32/150 (21%), Positives = 62/150 (41%), Gaps = 20/150 (13%)

Query: 154  EKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTE---GPHVGLVQAS 210
            +++    D   D+AF++D +      +FN  K ++  +   L +  +     H   V   
Sbjct: 2001 DRRAAGSDVDIDMAFILDSAETTTLFQFNEMKKYIAYLVRQLDMSPDPKASQHFARVAVV 2060

Query: 211  EHP-------------KIEFYLKNFTSAKDVL-FAIKEVGFRGGNSNTGKALKHTAQKFF 256
            +H              K+EF L ++ S + ++ F  + +    G    G A+++T +  F
Sbjct: 2061 QHAPSESVDNASMPPVKVEFSLTDYGSKEKLVDFLSRGMTQLQGTRALGSAIEYTIENVF 2120

Query: 257  TVDAGVRKGIPKVVVVFIDG-WPSDDIEEA 285
                  R    K+VV+ + G  P   +EEA
Sbjct: 2121 ESAPNPRD--LKIVVLMLTGEVPEQQLEEA 2148


>gi|40805823 collagen, type XXII, alpha 1 [Homo sapiens]
          Length = 1626

 Score =  120 bits (301), Expect = 3e-27
 Identities = 68/201 (33%), Positives = 109/201 (54%), Gaps = 8/201 (3%)

Query: 351 CTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQ 410
           C  ++  C    Y+ V   FL+D SSSVG  +F  + ++V+N+  TFE+     ++  V+
Sbjct: 25  CQAQRAGCKSVHYDLV---FLLDTSSSVGKEDFEKVRQWVANLVDTFEVGPDRTRVGVVR 81

Query: 411 FTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPI-----RESP 465
           ++    T F    + ++E V A  R + Y  G T TGDA+ +     F P      R+  
Sbjct: 82  YSDRPTTAFELGLFGSQEEVKAAARRLAYHGGNTNTGDALRYITARSFSPHAGGRPRDRA 141

Query: 466 NKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTR 525
            K   +++TDG+S D V   AAAAH AGI IF+VGV  A  ++L+++AS+PK +H F   
Sbjct: 142 YKQVAILLTDGRSQDLVLDAAAAAHRAGIRIFAVGVGEALKEELEEIASEPKSAHVFHVS 201

Query: 526 EFTGLEPIVSDVIRGICRDFL 546
           +F  ++ I   + R +C + L
Sbjct: 202 DFNAIDKIRGKLRRRLCENVL 222



 Score = 85.9 bits (211), Expect = 9e-17
 Identities = 54/207 (26%), Positives = 99/207 (47%), Gaps = 14/207 (6%)

Query: 155 KKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPK 214
           ++ G K    D+ FL+D S ++G+  F   + +V  +     +G +   VG+V+ S+ P 
Sbjct: 28  QRAGCKSVHYDLVFLLDTSSSVGKEDFEKVRQWVANLVDTFEVGPDRTRVGVVRYSDRPT 87

Query: 215 IEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVR---KGIPKVVV 271
             F L  F S ++V  A + + + GGN+NTG AL++   + F+  AG R   +   +V +
Sbjct: 88  TAFELGLFGSQEEVKAAARRLAYHGGNTNTGDALRYITARSFSPHAGGRPRDRAYKQVAI 147

Query: 272 VFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSY 331
           +  DG   D + +A   A   G+ +F V V + + EEL         ++          +
Sbjct: 148 LLTDGRSQDLVLDAAAAAHRAGIRIFAVGVGEALKEEL---------EEIASEPKSAHVF 198

Query: 332 HMPNWFGTTKYVKPLVQKLCTHEQMMC 358
           H+ ++    K    L ++LC  E ++C
Sbjct: 199 HVSDFNAIDKIRGKLRRRLC--ENVLC 223


>gi|55743096 collagen, type XIV, alpha 1 [Homo sapiens]
          Length = 1796

 Score =  119 bits (297), Expect = 9e-27
 Identities = 57/178 (32%), Positives = 102/178 (57%), Gaps = 2/178 (1%)

Query: 367 NIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYST 426
           +I  L+DGS S+G  NFRL+  F+ N+   F++     +I   Q++ D R E+    +ST
Sbjct: 158 DIVILVDGSWSIGRFNFRLVRHFLENLVTAFDVGSEKTRIGLAQYSGDPRIEWHLNAFST 217

Query: 427 KENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRESPN--KNFLVIVTDGQSYDDVQG 484
           K+ V+  +RN+ Y  G T TG A+++   N F P   S        +++TDG+S DD+  
Sbjct: 218 KDEVIEAVRNLPYKGGNTLTGLALNYIFENSFKPEAGSRTGVSKIGILITDGKSQDDIIP 277

Query: 485 PAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRGIC 542
           P+    ++G+ +F++GV  A +++L+++AS+P  +H +   EF  +  +V  + R +C
Sbjct: 278 PSRNLRESGVELFAIGVKNADVNELQEIASEPDSTHVYNVAEFDLMHTVVESLTRTLC 335



 Score =  118 bits (295), Expect = 2e-26
 Identities = 67/181 (37%), Positives = 99/181 (54%), Gaps = 7/181 (3%)

Query: 367  NIAFLIDGSSSVGDSNFRLMLEFV-SNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYS 425
            ++ F++DGS S+GD NF  ++ F+ S +    +I   G ++A VQFT D RTEF    Y 
Sbjct: 1032 DLVFMVDGSWSIGDENFNKIISFLYSTVGALNKIGTDGTQVAMVQFTDDPRTEFKLNAYK 1091

Query: 426  TKENVLAVIRNIRYMSGGTATGDAISFTVRNVF----GPIRESPNKNFLVIVTDGQSYDD 481
            TKE +L  I++I Y  G T TG AI +    +F    G  R  P    +V++TDG+S DD
Sbjct: 1092 TKETLLDAIKHISYKGGNTKTGKAIKYVRDTLFTAESGTRRGIP--KVIVVITDGRSQDD 1149

Query: 482  VQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRGI 541
            V   +      G +IF++GVA A   +L  + SKP   H FF  +F   + I  ++I  +
Sbjct: 1150 VNKISREMQLDGYSIFAIGVADADYSELVSIGSKPSARHVFFVDDFDAFKKIEDELITFV 1209

Query: 542  C 542
            C
Sbjct: 1210 C 1210



 Score =  116 bits (290), Expect = 6e-26
 Identities = 63/168 (37%), Positives = 96/168 (57%), Gaps = 7/168 (4%)

Query: 143  PPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFV-GKVALMLGIGTEG 201
            PPT       P  K   K  KAD+ F++DGS++IG   FN   +F+   V  +  IGT+G
Sbjct: 1016 PPT------IPPAKEVCKAAKADLVFMVDGSWSIGDENFNKIISFLYSTVGALNKIGTDG 1069

Query: 202  PHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAG 261
              V +VQ ++ P+ EF L  + + + +L AIK + ++GGN+ TGKA+K+     FT ++G
Sbjct: 1070 TQVAMVQFTDDPRTEFKLNAYKTKETLLDAIKHISYKGGNTKTGKAIKYVRDTLFTAESG 1129

Query: 262  VRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEEL 309
             R+GIPKV+VV  DG   DD+ +     +  G ++F + VA     EL
Sbjct: 1130 TRRGIPKVIVVITDGRSQDDVNKISREMQLDGYSIFAIGVADADYSEL 1177



 Score = 99.8 bits (247), Expect = 6e-21
 Identities = 51/146 (34%), Positives = 84/146 (57%)

Query: 164 ADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFT 223
           ADI  L+DGS++IG+  F L ++F+  +     +G+E   +GL Q S  P+IE++L  F+
Sbjct: 157 ADIVILVDGSWSIGRFNFRLVRHFLENLVTAFDVGSEKTRIGLAQYSGDPRIEWHLNAFS 216

Query: 224 SAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDDIE 283
           +  +V+ A++ + ++GGN+ TG AL +  +  F  +AG R G+ K+ ++  DG   DDI 
Sbjct: 217 TKDEVIEAVRNLPYKGGNTLTGLALNYIFENSFKPEAGSRTGVSKIGILITDGKSQDDII 276

Query: 284 EAGIVAREFGVNVFIVSVAKPIPEEL 309
                 RE GV +F + V      EL
Sbjct: 277 PPSRNLRESGVELFAIGVKNADVNEL 302


>gi|93141049 collagen, type XII, alpha 1 short isoform precursor [Homo
            sapiens]
          Length = 1899

 Score =  117 bits (293), Expect = 3e-26
 Identities = 66/180 (36%), Positives = 103/180 (57%), Gaps = 5/180 (2%)

Query: 367  NIAFLIDGSSSVGDSNFRLMLEFVSNIAKTF-EISDIGAKIAAVQFTYDQRTEFSFTDYS 425
            +I FL D S S+GD NF  +++F+ N    F EIS  G +++ VQ++ + ++EF    Y+
Sbjct: 1159 DIVFLTDASWSIGDDNFNKVVKFIFNTVGGFDEISPAGIQVSFVQYSDEVKSEFKLNTYN 1218

Query: 426  TKENVLAVIRNIRYMSGGTATGDAISFTVRNVF---GPIRESPNKNFLVIVTDGQSYDDV 482
             K   L  ++NIRY  G T TG A++F    V      +R++  K  LV+VTDG+S D+V
Sbjct: 1219 DKALALGALQNIRYRGGNTRTGKALTFIKEKVLTWESGMRKNVPK-VLVVVTDGRSQDEV 1277

Query: 483  QGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRGIC 542
            +  A     +G ++F VGVA    ++L ++ASKP E H F   +F   E I  ++I  +C
Sbjct: 1278 KKAALVIQQSGFSVFVVGVADVDYNELANIASKPSERHVFIVDDFESFEKIEDNLITFVC 1337



 Score =  113 bits (283), Expect = 4e-25
 Identities = 61/179 (34%), Positives = 102/179 (56%), Gaps = 4/179 (2%)

Query: 367 NIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYST 426
           +I  L+DGS S+G +NFR +  F+S I + F+I     +IA  Q++ D RTE+    +  
Sbjct: 35  DIVLLVDGSWSIGRANFRTVRSFISRIVEVFDIGPKRVQIALAQYSGDPRTEWQLNAHRD 94

Query: 427 KENVLAVIRNIRYMSGGTATGDAISFTVRNVF---GPIRESPNKNFLVIVTDGQSYDDVQ 483
           K+++L  + N+ Y  G T TG A++F  +  F     +R    K   V++TDG+S DDV+
Sbjct: 95  KKSLLQAVANLPYKGGNTLTGMALNFIRQQNFRTQAGMRPRARK-IGVLITDGKSQDDVE 153

Query: 484 GPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRGIC 542
            P+    D G+ +F++G+  A   +LK +A+ P ++HA+   +F  L  IV D+   +C
Sbjct: 154 APSKKLKDEGVELFAIGIKNADEVELKMIATDPDDTHAYNVADFESLSRIVDDLTINLC 212



 Score =  105 bits (262), Expect = 1e-22
 Identities = 63/171 (36%), Positives = 90/171 (52%), Gaps = 1/171 (0%)

Query: 143  PPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFV-GKVALMLGIGTEG 201
            PPT       P  +   K  KADI FL D S++IG   FN    F+   V     I   G
Sbjct: 1137 PPTPPPPPTIPPARDVCKGAKADIVFLTDASWSIGDDNFNKVVKFIFNTVGGFDEISPAG 1196

Query: 202  PHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAG 261
              V  VQ S+  K EF L  +      L A++ + +RGGN+ TGKAL    +K  T ++G
Sbjct: 1197 IQVSFVQYSDEVKSEFKLNTYNDKALALGALQNIRYRGGNTRTGKALTFIKEKVLTWESG 1256

Query: 262  VRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMV 312
            +RK +PKV+VV  DG   D++++A +V ++ G +VF+V VA     EL  +
Sbjct: 1257 MRKNVPKVLVVVTDGRSQDEVKKAALVIQQSGFSVFVVGVADVDYNELANI 1307



 Score = 89.7 bits (221), Expect = 6e-18
 Identities = 47/150 (31%), Positives = 79/150 (52%)

Query: 163 KADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNF 222
           +ADI  L+DGS++IG+  F   ++F+ ++  +  IG +   + L Q S  P+ E+ L   
Sbjct: 33  EADIVLLVDGSWSIGRANFRTVRSFISRIVEVFDIGPKRVQIALAQYSGDPRTEWQLNAH 92

Query: 223 TSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDDI 282
              K +L A+  + ++GGN+ TG AL    Q+ F   AG+R    K+ V+  DG   DD+
Sbjct: 93  RDKKSLLQAVANLPYKGGNTLTGMALNFIRQQNFRTQAGMRPRARKIGVLITDGKSQDDV 152

Query: 283 EEAGIVAREFGVNVFIVSVAKPIPEELGMV 312
           E      ++ GV +F + +      EL M+
Sbjct: 153 EAPSKKLKDEGVELFAIGIKNADEVELKMI 182


>gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]
          Length = 937

 Score =  108 bits (271), Expect = 1e-23
 Identities = 58/197 (29%), Positives = 112/197 (56%), Gaps = 7/197 (3%)

Query: 358 CSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRT 417
           C K     +++ F+IDGS S+G+ NF ++ +FV+ I  +  IS   A++  +Q++    T
Sbjct: 646 CKKCTEGPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHT 705

Query: 418 EFSFTDYSTKENVLAVIRNIRYMSGGTATGDAI------SFTVRNVFGPIRESPNKNFLV 471
           EF+  ++++ +++   + +++YM  G+ TG A+      SFT      P+  +      +
Sbjct: 706 EFTLRNFNSAKDMKKAVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPL-STRVPRAAI 764

Query: 472 IVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLE 531
           + TDG++ DDV   A+ A   GIT+++VGV  A  ++L+++AS+P   H F+  +F+ ++
Sbjct: 765 VFTDGRAQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMD 824

Query: 532 PIVSDVIRGICRDFLES 548
            I   + +GIC    +S
Sbjct: 825 EISEKLKKGICEALEDS 841



 Score =  102 bits (255), Expect = 7e-22
 Identities = 61/199 (30%), Positives = 102/199 (51%), Gaps = 9/199 (4%)

Query: 352 THEQM-MCSKTCYNS-VNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAV 409
           TH Q  +   +C N   ++ F+ID S SV   ++  + EF+ +I +  +I     ++  +
Sbjct: 40  THPQTALLESSCENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLL 99

Query: 410 QFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFG------PIRE 463
           Q+    + EFS   +  K  V   ++ +R++S GT TG AI + +   F       P+RE
Sbjct: 100 QYGSTVKNEFSLKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRE 159

Query: 464 SPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFF 523
           +  +  ++IVTDG+  D V   AA A D GI IF++GV     + LK + S+P E H F 
Sbjct: 160 NVPR-VIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFL 218

Query: 524 TREFTGLEPIVSDVIRGIC 542
              F+ +E + S   + +C
Sbjct: 219 VANFSQIETLTSVFQKKLC 237



 Score =  102 bits (254), Expect = 9e-22
 Identities = 62/167 (37%), Positives = 87/167 (52%), Gaps = 10/167 (5%)

Query: 146 GKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVG 205
           G+R KK  E          D+ F+IDGS ++G+  F + K FV  +   L I  +   VG
Sbjct: 643 GRRCKKCTEGPI-------DLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVG 695

Query: 206 LVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVR-- 263
           L+Q S     EF L+NF SAKD+  A+  + + G  S TG ALKH  ++ FT   G R  
Sbjct: 696 LLQYSTQVHTEFTLRNFNSAKDMKKAVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPL 755

Query: 264 -KGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEEL 309
              +P+  +VF DG   DD+ E    A+  G+ ++ V V K I EEL
Sbjct: 756 STRVPRAAIVFTDGRAQDDVSEWASKAKANGITMYAVGVGKAIEEEL 802



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 59/236 (25%), Positives = 100/236 (42%), Gaps = 17/236 (7%)

Query: 146 GKRLKKTPEKKTGNKDC---KADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGP 202
           G+  +  P+       C   +AD+ F+ID S ++    +   K F+  +   L IG +  
Sbjct: 35  GRHARTHPQTALLESSCENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVT 94

Query: 203 HVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAG- 261
            VGL+Q     K EF LK F    +V  A+K +      + TG A+++     F+   G 
Sbjct: 95  RVGLLQYGSTVKNEFSLKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGA 154

Query: 262 --VRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVD 319
             +R+ +P+V+++  DG P D + E    AR+ G+ +F + V +     L  +      D
Sbjct: 155 RPLRENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHED 214

Query: 320 KAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGS 375
                      + + N+           +KLCT    MCS   +N  +    I GS
Sbjct: 215 HV---------FLVANFSQIETLTSVFQKKLCTAH--MCSTLEHNCAHFCINIPGS 259


>gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]
          Length = 956

 Score =  108 bits (271), Expect = 1e-23
 Identities = 58/197 (29%), Positives = 112/197 (56%), Gaps = 7/197 (3%)

Query: 358 CSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRT 417
           C K     +++ F+IDGS S+G+ NF ++ +FV+ I  +  IS   A++  +Q++    T
Sbjct: 646 CKKCTEGPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHT 705

Query: 418 EFSFTDYSTKENVLAVIRNIRYMSGGTATGDAI------SFTVRNVFGPIRESPNKNFLV 471
           EF+  ++++ +++   + +++YM  G+ TG A+      SFT      P+  +      +
Sbjct: 706 EFTLRNFNSAKDMKKAVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPL-STRVPRAAI 764

Query: 472 IVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLE 531
           + TDG++ DDV   A+ A   GIT+++VGV  A  ++L+++AS+P   H F+  +F+ ++
Sbjct: 765 VFTDGRAQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMD 824

Query: 532 PIVSDVIRGICRDFLES 548
            I   + +GIC    +S
Sbjct: 825 EISEKLKKGICEALEDS 841



 Score =  102 bits (255), Expect = 7e-22
 Identities = 61/199 (30%), Positives = 102/199 (51%), Gaps = 9/199 (4%)

Query: 352 THEQM-MCSKTCYNS-VNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAV 409
           TH Q  +   +C N   ++ F+ID S SV   ++  + EF+ +I +  +I     ++  +
Sbjct: 40  THPQTALLESSCENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLL 99

Query: 410 QFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFG------PIRE 463
           Q+    + EFS   +  K  V   ++ +R++S GT TG AI + +   F       P+RE
Sbjct: 100 QYGSTVKNEFSLKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRE 159

Query: 464 SPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFF 523
           +  +  ++IVTDG+  D V   AA A D GI IF++GV     + LK + S+P E H F 
Sbjct: 160 NVPR-VIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFL 218

Query: 524 TREFTGLEPIVSDVIRGIC 542
              F+ +E + S   + +C
Sbjct: 219 VANFSQIETLTSVFQKKLC 237



 Score =  102 bits (254), Expect = 9e-22
 Identities = 62/167 (37%), Positives = 87/167 (52%), Gaps = 10/167 (5%)

Query: 146 GKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVG 205
           G+R KK  E          D+ F+IDGS ++G+  F + K FV  +   L I  +   VG
Sbjct: 643 GRRCKKCTEGPI-------DLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVG 695

Query: 206 LVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVR-- 263
           L+Q S     EF L+NF SAKD+  A+  + + G  S TG ALKH  ++ FT   G R  
Sbjct: 696 LLQYSTQVHTEFTLRNFNSAKDMKKAVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPL 755

Query: 264 -KGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEEL 309
              +P+  +VF DG   DD+ E    A+  G+ ++ V V K I EEL
Sbjct: 756 STRVPRAAIVFTDGRAQDDVSEWASKAKANGITMYAVGVGKAIEEEL 802



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 59/236 (25%), Positives = 100/236 (42%), Gaps = 17/236 (7%)

Query: 146 GKRLKKTPEKKTGNKDC---KADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGP 202
           G+  +  P+       C   +AD+ F+ID S ++    +   K F+  +   L IG +  
Sbjct: 35  GRHARTHPQTALLESSCENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVT 94

Query: 203 HVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAG- 261
            VGL+Q     K EF LK F    +V  A+K +      + TG A+++     F+   G 
Sbjct: 95  RVGLLQYGSTVKNEFSLKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGA 154

Query: 262 --VRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVD 319
             +R+ +P+V+++  DG P D + E    AR+ G+ +F + V +     L  +      D
Sbjct: 155 RPLRENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHED 214

Query: 320 KAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGS 375
                      + + N+           +KLCT    MCS   +N  +    I GS
Sbjct: 215 HV---------FLVANFSQIETLTSVFQKKLCTAH--MCSTLEHNCAHFCINIPGS 259


>gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens]
          Length = 2944

 Score =  105 bits (263), Expect = 8e-23
 Identities = 65/192 (33%), Positives = 101/192 (52%), Gaps = 5/192 (2%)

Query: 354 EQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFE--ISDIGAKIAAVQF 411
           E++ C++    + +I FL+DGSSS+G SNFR +  F+  +   F    S  G + A VQ+
Sbjct: 27  ERVTCTRLY--AADIVFLLDGSSSIGRSNFREVRSFLEGLVLPFSGAASAQGVRFATVQY 84

Query: 412 TYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRESPN-KNFL 470
           + D RTEF      +  +V+  IR + Y  G T TG AI     +VF P    P      
Sbjct: 85  SDDPRTEFGLDALGSGGDVIRAIRELSYKGGNTRTGAAILHVADHVFLPQLARPGVPKVC 144

Query: 471 VIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGL 530
           +++TDG+S D V   A      G+ +F+VG+  A  ++LK +AS+P     FF  +F+ L
Sbjct: 145 ILITDGKSQDLVDTAAQRLKGQGVKLFAVGIKNADPEELKRVASQPTSDFFFFVNDFSIL 204

Query: 531 EPIVSDVIRGIC 542
             ++  V R +C
Sbjct: 205 RTLLPLVSRRVC 216



 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 66/202 (32%), Positives = 99/202 (49%), Gaps = 14/202 (6%)

Query: 154 EKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLG--IGTEGPHVGLVQASE 211
           E+ T  +   ADI FL+DGS +IG+  F   ++F+  + L        +G     VQ S+
Sbjct: 27  ERVTCTRLYAADIVFLLDGSSSIGRSNFREVRSFLEGLVLPFSGAASAQGVRFATVQYSD 86

Query: 212 HPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKVVV 271
            P+ EF L    S  DV+ AI+E+ ++GGN+ TG A+ H A   F      R G+PKV +
Sbjct: 87  DPRTEFGLDALGSGGDVIRAIRELSYKGGNTRTGAAILHVADHVFLPQL-ARPGVPKVCI 145

Query: 272 VFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSY 331
           +  DG   D ++ A    +  GV +F V +    PEEL  V      D        FF +
Sbjct: 146 LITDGKSQDLVDTAAQRLKGQGVKLFAVGIKNADPEELKRVASQPTSD--------FFFF 197

Query: 332 HMPNWFGTTKYVKPLV-QKLCT 352
              N F   + + PLV +++CT
Sbjct: 198 --VNDFSILRTLLPLVSRRVCT 217



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 39/149 (26%), Positives = 68/149 (45%), Gaps = 4/149 (2%)

Query: 164  ADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLG-IGTEGPHVGLVQASEHPKIEFYLKNF 222
            AD+ FL   + +    R    +  + ++ L LG +G +   VGL+  S  P   F L   
Sbjct: 1053 ADVVFLPHATQD-NAHRAEATRRVLERLVLALGPLGPQAVQVGLLSYSHRPSPLFPLNGS 1111

Query: 223  TSAKDVLFAIKEVGFRG-GNSNTGKALKHTAQKFFTVDA-GVRKGIPKVVVVFIDGWPSD 280
                 +L  I+++ +     +N G A+    +     DA G R+ +P V+V+ +D     
Sbjct: 1112 HDLGIILQRIRDMPYMDPSGNNLGTAVVTAHRYMLAPDAPGRRQHVPGVMVLLVDEPLRG 1171

Query: 281  DIEEAGIVAREFGVNVFIVSVAKPIPEEL 309
            DI      A+  G+NV ++ +A   PE+L
Sbjct: 1172 DIFSPIREAQASGLNVVMLGMAGADPEQL 1200



 Score = 33.5 bits (75), Expect = 0.52
 Identities = 29/127 (22%), Positives = 55/127 (43%), Gaps = 9/127 (7%)

Query: 430  VLAVIRNIRYMS-GGTATGDAISFTVRNVFGPIRESPNKN-----FLVIVTDGQSYDDVQ 483
            +L  IR++ YM   G   G A+    R +  P  ++P +       +V++ D     D+ 
Sbjct: 1117 ILQRIRDMPYMDPSGNNLGTAVVTAHRYMLAP--DAPGRRQHVPGVMVLLVDEPLRGDIF 1174

Query: 484  GPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFF-TREFTGLEPIVSDVIRGIC 542
             P   A  +G+ +  +G+A A  + L+ +A        FF   +   L+  VS +   +C
Sbjct: 1175 SPIREAQASGLNVVMLGMAGADPEQLRRLAPGMDSVQTFFAVDDGPSLDQAVSGLATALC 1234

Query: 543  RDFLESQ 549
            +    +Q
Sbjct: 1235 QASFTTQ 1241


>gi|18780273 collagen, type XXI, alpha 1 precursor [Homo sapiens]
          Length = 957

 Score =  104 bits (259), Expect = 2e-22
 Identities = 56/179 (31%), Positives = 100/179 (55%), Gaps = 2/179 (1%)

Query: 367 NIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYST 426
           ++ F++DGS SVG  NF ++ +++ NI K F+I     ++  VQ++     E     Y +
Sbjct: 37  DLVFILDGSYSVGPENFEIVKKWLVNITKNFDIGPKFIQVGVVQYSDYPVLEIPLGSYDS 96

Query: 427 KENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRESPNKNFLVIVTDGQSYDDVQGPA 486
            E++ A + +I Y+ G T TG AI F +  +F        K   V++TDG+S DDV+  A
Sbjct: 97  GEHLTAAVESILYLGGNTKTGKAIQFALDYLFAKSSRFLTK-IAVVLTDGKSQDDVKDAA 155

Query: 487 AAAHDAGITIFSVGVAWAPLD-DLKDMASKPKESHAFFTREFTGLEPIVSDVIRGICRD 544
            AA D+ IT+F++GV     D +L+ +A+KP  ++ F+  ++  +  I   + + +C +
Sbjct: 156 QAARDSKITLFAIGVGSETEDAELRAIANKPSSTYVFYVEDYIAISKIREVMKQKLCEE 214



 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 52/211 (24%), Positives = 108/211 (51%), Gaps = 15/211 (7%)

Query: 149 LKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQ 208
           L +  E ++  +    D+ F++DGS+++G   F + K ++  +     IG +   VG+VQ
Sbjct: 21  LAEDGEVRSSCRTAPTDLVFILDGSYSVGPENFEIVKKWLVNITKNFDIGPKFIQVGVVQ 80

Query: 209 ASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPK 268
            S++P +E  L ++ S + +  A++ + + GGN+ TGKA++      F   A   + + K
Sbjct: 81  YSDYPVLEIPLGSYDSGEHLTAAVESILYLGGNTKTGKAIQFALDYLF---AKSSRFLTK 137

Query: 269 VVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPE-ELGMVQDVTFVDKAVCRNNG 327
           + VV  DG   DD+++A   AR+  + +F + V     + EL  + +         + + 
Sbjct: 138 IAVVLTDGKSQDDVKDAAQAARDSKITLFAIGVGSETEDAELRAIAN---------KPSS 188

Query: 328 FFSYHMPNWFGTTKYVKPLVQKLCTHEQMMC 358
            + +++ ++   +K  + + QKLC  E+ +C
Sbjct: 189 TYVFYVEDYIAISKIREVMKQKLC--EESVC 217


>gi|112734845 collagen, type XX, alpha 1 [Homo sapiens]
          Length = 1284

 Score =  104 bits (259), Expect = 2e-22
 Identities = 60/180 (33%), Positives = 100/180 (55%), Gaps = 4/180 (2%)

Query: 367 NIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYST 426
           ++ FL+DGS S+G S+F+ + +F++++   FEI     ++   Q++ D +TE+     ST
Sbjct: 179 DMVFLVDGSWSIGHSHFQQVKDFLASVIAPFEIGPDKVQVGLTQYSGDAQTEWDLNSLST 238

Query: 427 KENVLAVIRNIRYMSGGTATGDAISFTVRNVFGP---IRESPNKNFLVIVTDGQSYDDVQ 483
           KE VLA +R +RY  G T TG A++  +     P   +R    K  +++VTDG+S DDV 
Sbjct: 239 KEQVLAAVRRLRYKGGNTFTGLALTHVLGQNLQPAAGLRPEAAK-VVILVTDGKSQDDVH 297

Query: 484 GPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRGICR 543
             A    D G+ +F+VGV  A   +L+ +AS P++       +F  L  +   + R IC+
Sbjct: 298 TAARVLKDLGVNVFAVGVKNADEAELRLLASPPRDITVHSVLDFLQLGALAGLLSRLICQ 357



 Score = 96.7 bits (239), Expect = 5e-20
 Identities = 54/149 (36%), Positives = 82/149 (55%)

Query: 164 ADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFT 223
           AD+ FL+DGS++IG   F   K+F+  V     IG +   VGL Q S   + E+ L + +
Sbjct: 178 ADMVFLVDGSWSIGHSHFQQVKDFLASVIAPFEIGPDKVQVGLTQYSGDAQTEWDLNSLS 237

Query: 224 SAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDDIE 283
           + + VL A++ + ++GGN+ TG AL H   +     AG+R    KVV++  DG   DD+ 
Sbjct: 238 TKEQVLAAVRRLRYKGGNTFTGLALTHVLGQNLQPAAGLRPEAAKVVILVTDGKSQDDVH 297

Query: 284 EAGIVAREFGVNVFIVSVAKPIPEELGMV 312
            A  V ++ GVNVF V V      EL ++
Sbjct: 298 TAARVLKDLGVNVFAVGVKNADEAELRLL 326


>gi|89191868 von Willebrand factor preproprotein [Homo sapiens]
          Length = 2813

 Score =  103 bits (257), Expect = 4e-22
 Identities = 87/353 (24%), Positives = 159/353 (45%), Gaps = 39/353 (11%)

Query: 165  DIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTS 224
            D+AF+++GS  IG+  FN  K F+ +V   + +G +  HV ++Q S    +E+      S
Sbjct: 1498 DVAFVLEGSDKIGEADFNRSKEFMEEVIQRMDVGQDSIHVTVLQYSYMVTVEYPFSEAQS 1557

Query: 225  AKDVLFAIKEVGFRGGN-SNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDDIE 283
              D+L  ++E+ ++GGN +NTG AL++ +   F V  G R+  P +V +      SD+I+
Sbjct: 1558 KGDILQRVREIRYQGGNRTNTGLALRYLSDHSFLVSQGDREQAPNLVYMVTGNPASDEIK 1617

Query: 284  ----EAGIVAREFGVNVFIVSVAK-PIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFG 338
                +  +V    G N  +  + +   P    ++QD                      F 
Sbjct: 1618 RLPGDIQVVPIGVGPNANVQELERIGWPNAPILIQD----------------------FE 1655

Query: 339  TTKYVKP--LVQKLCTHEQMMC-----SKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVS 391
            T     P  ++Q+ C+ E +       +  C   +++  L+DGSSS   S F  M  F  
Sbjct: 1656 TLPREAPDLVLQRCCSGEGLQIPTLSPAPDCSQPLDVILLLDGSSSFPASYFDEMKSFAK 1715

Query: 392  NIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAIS 451
                   I     +++ +Q+      +  +     K ++L+++  ++   G +  GDA+ 
Sbjct: 1716 AFISKANIGPRLTQVSVLQYGSITTIDVPWNVVPEKAHLLSLVDVMQREGGPSQIGDALG 1775

Query: 452  FTVRNVFGPI---RESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGV 501
            F VR +   +   R   +K  +++VTD  S D V   A AA    +T+F +G+
Sbjct: 1776 FAVRYLTSEMHGARPGASKAVVILVTD-VSVDSVDAAADAARSNRVTVFPIGI 1827



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 74/355 (20%), Positives = 150/355 (42%), Gaps = 50/355 (14%)

Query: 165  DIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTS 224
            D+ FL+DGS  + +  F + K FV  +   L I  +   V +V+  +       LK+   
Sbjct: 1277 DLVFLLDGSSRLSEAEFEVLKAFVVDMMERLRISQKWVRVAVVEYHDGSHAYIGLKDRKR 1336

Query: 225  AKDVLFAIKEVGFRGGN-SNTGKALKHTA-QKFFTVDAGVRKGIPKVVVVFIDGWPSDDI 282
              ++     +V + G   ++T + LK+T  Q F  +D   R    ++ ++ +        
Sbjct: 1337 PSELRRIASQVKYAGSQVASTSEVLKYTLFQIFSKID---RPEASRITLLLMAS------ 1387

Query: 283  EEAGIVAREFGVNVFIVSVAKPIPEELGM-----VQDVTFVDKAVCRNNGFFSYHMPNWF 337
            +E   ++R F   V  +   K I   +G+     ++ +  ++K    N  F    +    
Sbjct: 1388 QEPQRMSRNFVRYVQGLKKKKVIVIPVGIGPHANLKQIRLIEKQAPENKAFVLSSVDE-- 1445

Query: 338  GTTKYVKPLVQKLC---------THEQMMCSKTC-------------YNSV--NIAFLID 373
               +    +V  LC         T    M   T               NS+  ++AF+++
Sbjct: 1446 -LEQQRDEIVSYLCDLAPEAPPPTLPPDMAQVTVGPGLLGVSTLGPKRNSMVLDVAFVLE 1504

Query: 374  GSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAV 433
            GS  +G+++F    EF+  + +  ++      +  +Q++Y    E+ F++  +K ++L  
Sbjct: 1505 GSDKIGEADFNRSKEFMEEVIQRMDVGQDSIHVTVLQYSYMVTVEYPFSEAQSKGDILQR 1564

Query: 434  IRNIRYMSGG-TATGDAISFTVRNVF----GPIRESPNKNFLVIVTDGQSYDDVQ 483
            +R IRY  G  T TG A+ +   + F    G   ++P  N + +VT   + D+++
Sbjct: 1565 VREIRYQGGNRTNTGLALRYLSDHSFLVSQGDREQAP--NLVYMVTGNPASDEIK 1617



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 32/187 (17%), Positives = 73/187 (39%), Gaps = 6/187 (3%)

Query: 362  CYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSF 421
            C   +++ FL+DGSS + ++ F ++  FV ++ +   IS    ++A V++          
Sbjct: 1272 CSRLLDLVFLLDGSSRLSEAEFEVLKAFVVDMMERLRISQKWVRVAVVEYHDGSHAYIGL 1331

Query: 422  TDYSTKENVLAVIRNIRYMSGGTA-TGDAISFTVRNVFGPIRESPNKNFLVIVTDGQSYD 480
             D      +  +   ++Y     A T + + +T+  +F  I         +++   Q   
Sbjct: 1332 KDRKRPSELRRIASQVKYAGSQVASTSEVLKYTLFQIFSKIDRPEASRITLLLMASQEPQ 1391

Query: 481  DVQGP----AAAAHDAGITIFSVGVA-WAPLDDLKDMASKPKESHAFFTREFTGLEPIVS 535
             +               + +  VG+   A L  ++ +  +  E+ AF       LE    
Sbjct: 1392 RMSRNFVRYVQGLKKKKVIVIPVGIGPHANLKQIRLIEKQAPENKAFVLSSVDELEQQRD 1451

Query: 536  DVIRGIC 542
            +++  +C
Sbjct: 1452 EIVSYLC 1458



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 35/143 (24%), Positives = 54/143 (37%), Gaps = 2/143 (1%)

Query: 161  DCKA--DIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFY 218
            DC    D+  L+DGS +     F+  K+F         IG     V ++Q      I+  
Sbjct: 1685 DCSQPLDVILLLDGSSSFPASYFDEMKSFAKAFISKANIGPRLTQVSVLQYGSITTIDVP 1744

Query: 219  LKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWP 278
                     +L  +  +   GG S  G AL    +   +   G R G  K VV+ +    
Sbjct: 1745 WNVVPEKAHLLSLVDVMQREGGPSQIGDALGFAVRYLTSEMHGARPGASKAVVILVTDVS 1804

Query: 279  SDDIEEAGIVAREFGVNVFIVSV 301
             D ++ A   AR   V VF + +
Sbjct: 1805 VDSVDAAADAARSNRVTVFPIGI 1827


>gi|13699834 matrilin 4 isoform 2 precursor [Homo sapiens]
          Length = 540

 Score =  103 bits (256), Expect = 5e-22
 Identities = 60/190 (31%), Positives = 98/190 (51%), Gaps = 5/190 (2%)

Query: 358 CSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRT 417
           C++     V++  L+DGS SV   NF L+  FV+ I    ++S  G ++  VQF+   RT
Sbjct: 295 CNRCREGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRT 354

Query: 418 EFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRESPNKNFLV-----I 472
           EF    Y T   V   +  + YM  GT TG A+   V + F   + +  +   V     +
Sbjct: 355 EFPLGRYGTAAEVKQAVLAVEYMERGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLV 414

Query: 473 VTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEP 532
            TDG+S DD+   AA A + GI +++VGV  A   +L+++AS+P E H  +  +F  +  
Sbjct: 415 FTDGRSQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPAELHVSYAPDFGTMTH 474

Query: 533 IVSDVIRGIC 542
           ++ ++   IC
Sbjct: 475 LLENLRGSIC 484



 Score = 89.4 bits (220), Expect = 8e-18
 Identities = 54/169 (31%), Positives = 86/169 (50%), Gaps = 3/169 (1%)

Query: 144 PTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPH 203
           P G++L+   +     ++   D+  L+DGS ++  + F L K FV ++   L +  EG  
Sbjct: 283 PEGRQLQADGKSCNRCREGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTR 342

Query: 204 VGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVR 263
           VGLVQ S   + EF L  + +A +V  A+  V +    + TG AL+H  +  F+   G R
Sbjct: 343 VGLVQFSSRVRTEFPLGRYGTAAEVKQAVLAVEYMERGTMTGLALRHMVEHSFSEAQGAR 402

Query: 264 K---GIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEEL 309
                +P+V +VF DG   DDI      A+E G+ ++ V V K +  EL
Sbjct: 403 PRALNVPRVGLVFTDGRSQDDISVWAARAKEEGIVMYAVGVGKAVEAEL 451



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 53/187 (28%), Positives = 88/187 (47%), Gaps = 5/187 (2%)

Query: 346 LVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAK 405
           L+Q   T  Q+   +     +++ F+ID S SV    F  M +F+  + +   +     +
Sbjct: 13  LLQPWETQLQLTGPRCHTGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATR 72

Query: 406 IAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIR--- 462
           +  +Q++   ++ F    +S +E++   IR++  ++ GT TG AI + +   F       
Sbjct: 73  VGVIQYSSQVQSVFPLRAFSRREDMERAIRDLVPLAQGTMTGLAIQYAMNVAFSVAEGAR 132

Query: 463 --ESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESH 520
             E       VIVTDG+  D V   AA A   GI I++VGV  A +  L+ MAS P + H
Sbjct: 133 PPEERVPRVAVIVTDGRPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEH 192

Query: 521 AFFTREF 527
            F    F
Sbjct: 193 VFLVESF 199



 Score = 66.2 bits (160), Expect = 7e-11
 Identities = 39/142 (27%), Positives = 71/142 (50%), Gaps = 3/142 (2%)

Query: 165 DIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTS 224
           D+ F+ID S ++    F   + F+  +   L +G     VG++Q S   +  F L+ F+ 
Sbjct: 34  DLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLRAFSR 93

Query: 225 AKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVR---KGIPKVVVVFIDGWPSDD 281
            +D+  AI+++      + TG A+++     F+V  G R   + +P+V V+  DG P D 
Sbjct: 94  REDMERAIRDLVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGRPQDR 153

Query: 282 IEEAGIVAREFGVNVFIVSVAK 303
           + E    AR  G+ ++ V V +
Sbjct: 154 VAEVAAQARARGIEIYAVGVQR 175


>gi|13699830 matrilin 4 isoform 1 precursor [Homo sapiens]
          Length = 581

 Score =  103 bits (256), Expect = 5e-22
 Identities = 60/190 (31%), Positives = 98/190 (51%), Gaps = 5/190 (2%)

Query: 358 CSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRT 417
           C++     V++  L+DGS SV   NF L+  FV+ I    ++S  G ++  VQF+   RT
Sbjct: 336 CNRCREGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRT 395

Query: 418 EFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRESPNKNFLV-----I 472
           EF    Y T   V   +  + YM  GT TG A+   V + F   + +  +   V     +
Sbjct: 396 EFPLGRYGTAAEVKQAVLAVEYMERGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLV 455

Query: 473 VTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEP 532
            TDG+S DD+   AA A + GI +++VGV  A   +L+++AS+P E H  +  +F  +  
Sbjct: 456 FTDGRSQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPAELHVSYAPDFGTMTH 515

Query: 533 IVSDVIRGIC 542
           ++ ++   IC
Sbjct: 516 LLENLRGSIC 525



 Score = 89.4 bits (220), Expect = 8e-18
 Identities = 54/169 (31%), Positives = 86/169 (50%), Gaps = 3/169 (1%)

Query: 144 PTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPH 203
           P G++L+   +     ++   D+  L+DGS ++  + F L K FV ++   L +  EG  
Sbjct: 324 PEGRQLQADGKSCNRCREGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTR 383

Query: 204 VGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVR 263
           VGLVQ S   + EF L  + +A +V  A+  V +    + TG AL+H  +  F+   G R
Sbjct: 384 VGLVQFSSRVRTEFPLGRYGTAAEVKQAVLAVEYMERGTMTGLALRHMVEHSFSEAQGAR 443

Query: 264 K---GIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEEL 309
                +P+V +VF DG   DDI      A+E G+ ++ V V K +  EL
Sbjct: 444 PRALNVPRVGLVFTDGRSQDDISVWAARAKEEGIVMYAVGVGKAVEAEL 492



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 53/187 (28%), Positives = 88/187 (47%), Gaps = 5/187 (2%)

Query: 346 LVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAK 405
           L+Q   T  Q+   +     +++ F+ID S SV    F  M +F+  + +   +     +
Sbjct: 13  LLQPWETQLQLTGPRCHTGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATR 72

Query: 406 IAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIR--- 462
           +  +Q++   ++ F    +S +E++   IR++  ++ GT TG AI + +   F       
Sbjct: 73  VGVIQYSSQVQSVFPLRAFSRREDMERAIRDLVPLAQGTMTGLAIQYAMNVAFSVAEGAR 132

Query: 463 --ESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESH 520
             E       VIVTDG+  D V   AA A   GI I++VGV  A +  L+ MAS P + H
Sbjct: 133 PPEERVPRVAVIVTDGRPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEH 192

Query: 521 AFFTREF 527
            F    F
Sbjct: 193 VFLVESF 199



 Score = 66.2 bits (160), Expect = 7e-11
 Identities = 39/142 (27%), Positives = 71/142 (50%), Gaps = 3/142 (2%)

Query: 165 DIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTS 224
           D+ F+ID S ++    F   + F+  +   L +G     VG++Q S   +  F L+ F+ 
Sbjct: 34  DLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLRAFSR 93

Query: 225 AKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVR---KGIPKVVVVFIDGWPSDD 281
            +D+  AI+++      + TG A+++     F+V  G R   + +P+V V+  DG P D 
Sbjct: 94  REDMERAIRDLVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGRPQDR 153

Query: 282 IEEAGIVAREFGVNVFIVSVAK 303
           + E    AR  G+ ++ V V +
Sbjct: 154 VAEVAAQARARGIEIYAVGVQR 175


>gi|38348304 von Willebrand factor A domain containing 2 [Homo
           sapiens]
          Length = 725

 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 55/183 (30%), Positives = 92/183 (50%), Gaps = 3/183 (1%)

Query: 344 KPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIG 403
           K  + K+    +MM    C  +V+I FL+DGS+SVG  +F     F   +    +IS   
Sbjct: 31  KETIGKISAASKMMW---CSAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPER 87

Query: 404 AKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRE 463
            ++ A QF+     EF    +ST++ V A I+ + +  G T T  A+ + +       R 
Sbjct: 88  VRVGAFQFSSTPHLEFPLDSFSTQQEVKARIKRMVFKGGRTETELALKYLLHRGLPGGRN 147

Query: 464 SPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFF 523
           +     L+IVTDG+S  DV  P+    + G+T+F+VGV +   ++L  +AS+P+  H   
Sbjct: 148 ASVPQILIIVTDGKSQGDVALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLL 207

Query: 524 TRE 526
             +
Sbjct: 208 AEQ 210



 Score = 90.5 bits (223), Expect = 4e-18
 Identities = 87/362 (24%), Positives = 157/362 (43%), Gaps = 19/362 (5%)

Query: 161 DCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLK 220
           +C+ D+ FL+D S       F   K FV +    +        VG+   S    +   + 
Sbjct: 339 ECRVDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVG 398

Query: 221 NFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSD 280
            +    D+++++  + FRGG + TG AL+  A++ F       +  P+ VVV +    S+
Sbjct: 399 EYQDVPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSATRTGQDRPRRVVVLLTESHSE 458

Query: 281 DIEEAGIVAREFGVNVFIVSV-AKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGT 339
           D E AG         + ++ V ++ +  EL   +++T   K V        Y  P     
Sbjct: 459 D-EVAGPARHARARELLLLGVGSEAVRAEL---EEITGSPKHV------MVYSDPQ--DL 506

Query: 340 TKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEI 399
              +  L  KLC+ ++  C      ++++ F++D S+SVG  NF  M  FV + A  FE+
Sbjct: 507 FNQIPELQGKLCSRQRPGCRT---QALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEV 563

Query: 400 SDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFG 459
           +    ++  V +    +T F      T+  +L  I    Y+ G  + G A+      V  
Sbjct: 564 NPDVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMT 623

Query: 460 PIRESPN--KNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPK 517
             R +       +V++T G+  +D   PA    + GI++  VGV     + L+ +A  P+
Sbjct: 624 VQRGARPGVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAG-PR 682

Query: 518 ES 519
           +S
Sbjct: 683 DS 684



 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 56/172 (32%), Positives = 84/172 (48%), Gaps = 8/172 (4%)

Query: 165 DIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTS 224
           DI FL+DGS ++G+  F   K+F   V   L I  E   VG  Q S  P +EF L +F++
Sbjct: 51  DIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFST 110

Query: 225 AKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDDIEE 284
            ++V   IK + F+GG + T  ALK+   +   +  G    +P+++++  DG    D+  
Sbjct: 111 QQEVKARIKRMVFKGGRTETELALKYLLHR--GLPGGRNASVPQILIIVTDGKSQGDVAL 168

Query: 285 AGIVAREFGVNVFIVSVAKPIPEELGMV------QDVTFVDKAVCRNNGFFS 330
                +E GV VF V V  P  EEL  +      Q V   ++     NG FS
Sbjct: 169 PSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAEQVEDATNGLFS 220



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 47/160 (29%), Positives = 72/160 (45%)

Query: 150 KKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQA 209
           K    ++ G +    D+ F++D S ++G   F   ++FV   AL   +  +   VGLV  
Sbjct: 516 KLCSRQRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVY 575

Query: 210 SEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKV 269
               +  F L    +   +L AI +  + GG  + G AL H   K  TV  G R G+PK 
Sbjct: 576 GSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGARPGVPKA 635

Query: 270 VVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEEL 309
           VVV   G  ++D        R  G++V +V V   + E L
Sbjct: 636 VVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGL 675


>gi|11321565 matrilin 3 precursor [Homo sapiens]
          Length = 486

 Score = 89.4 bits (220), Expect = 8e-18
 Identities = 58/182 (31%), Positives = 88/182 (48%), Gaps = 5/182 (2%)

Query: 366 VNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYS 425
           +++ F+ID S SV    F  +  FVS I  T +I     ++A V +    + EF    Y+
Sbjct: 82  LDLVFIIDSSRSVRPLEFTKVKTFVSRIIDTLDIGPADTRVAVVNYASTVKIEFQLQAYT 141

Query: 426 TKENVLAVIRNIRYMSGGTATGDAISFTVRNVF----GPIRESPN-KNFLVIVTDGQSYD 480
            K+++   +  I  +S GT +G AI   +   F    G    S N     +IVTDG+  D
Sbjct: 142 DKQSLKQAVGRITPLSTGTMSGLAIQTAMDEAFTVEAGAREPSSNIPKVAIIVTDGRPQD 201

Query: 481 DVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRG 540
            V   AA A  +GI +++VGV  A +  LK MAS+P E H F+   +  +E + S     
Sbjct: 202 QVNEVAARAQASGIELYAVGVDRADMASLKMMASEPLEEHVFYVETYGVIEKLSSRFQET 261

Query: 541 IC 542
            C
Sbjct: 262 FC 263



 Score = 75.9 bits (185), Expect = 9e-14
 Identities = 55/205 (26%), Positives = 92/205 (44%), Gaps = 18/205 (8%)

Query: 153 PEKKTGNKDCKA---DIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQA 209
           P +  G   CK+   D+ F+ID S ++    F   K FV ++   L IG     V +V  
Sbjct: 68  PGRARGAGVCKSRPLDLVFIIDSSRSVRPLEFTKVKTFVSRIIDTLDIGPADTRVAVVNY 127

Query: 210 SEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRK---GI 266
           +   KIEF L+ +T  + +  A+  +      + +G A++    + FTV+AG R+    I
Sbjct: 128 ASTVKIEFQLQAYTDKQSLKQAVGRITPLSTGTMSGLAIQTAMDEAFTVEAGAREPSSNI 187

Query: 267 PKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSV------------AKPIPEELGMVQD 314
           PKV ++  DG P D + E    A+  G+ ++ V V            ++P+ E +  V+ 
Sbjct: 188 PKVAIIVTDGRPQDQVNEVAARAQASGIELYAVGVDRADMASLKMMASEPLEEHVFYVET 247

Query: 315 VTFVDKAVCRNNGFFSYHMPNWFGT 339
              ++K   R    F    P   GT
Sbjct: 248 YGVIEKLSSRFQETFCALDPCVLGT 272


>gi|40068485 von Willebrand factor A domain containing 1 isoform 1
           [Homo sapiens]
          Length = 445

 Score = 79.3 bits (194), Expect = 8e-15
 Identities = 44/141 (31%), Positives = 71/141 (50%)

Query: 163 KADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNF 222
           + D+ FL+D S ++    F+  + FVG++   L +GT      LV     P  EF     
Sbjct: 32  RGDLMFLLDSSASVSHYEFSRVREFVGQLVAPLPLGTGALRASLVHVGSRPYTEFPFGQH 91

Query: 223 TSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDDI 282
           +S +    A++    R G+++TG AL +  ++ F   +G R G+PKV+V   DG  SD +
Sbjct: 92  SSGEAAQDAVRASAQRMGDTHTGLALVYAKEQLFAEASGARPGVPKVLVWVTDGGSSDPV 151

Query: 283 EEAGIVAREFGVNVFIVSVAK 303
                  ++ GV VFIVS  +
Sbjct: 152 GPPMQELKDLGVTVFIVSTGR 172



 Score = 66.2 bits (160), Expect = 7e-11
 Identities = 54/186 (29%), Positives = 77/186 (41%), Gaps = 4/186 (2%)

Query: 367 NIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYST 426
           ++ FL+D S+SV    F  + EFV  +     +     + + V       TEF F  +S+
Sbjct: 34  DLMFLLDSSASVSHYEFSRVREFVGQLVAPLPLGTGALRASLVHVGSRPYTEFPFGQHSS 93

Query: 427 KENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRESPN--KNFLVIVTDGQSYDDVQG 484
            E     +R      G T TG A+ +    +F     +       LV VTDG S D V  
Sbjct: 94  GEAAQDAVRASAQRMGDTHTGLALVYAKEQLFAEASGARPGVPKVLVWVTDGGSSDPVGP 153

Query: 485 PAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRGICRD 544
           P     D G+T+F V        +L   AS P E H  F  +   L  IV + +RG   D
Sbjct: 154 PMQELKDLGVTVFIVSTGRGNFLELSAAASAPAEKHLHFV-DVDDLHIIVQE-LRGSILD 211

Query: 545 FLESQQ 550
            +  QQ
Sbjct: 212 AMRPQQ 217


>gi|34452173 integrin alpha X precursor [Homo sapiens]
          Length = 1163

 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 53/179 (29%), Positives = 88/179 (49%), Gaps = 16/179 (8%)

Query: 367 NIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYST 426
           +I FLIDGS S+   NF  M+ FV  +   F+      + + +QF+   +T F+F ++  
Sbjct: 151 DIVFLIDGSGSISSRNFATMMNFVRAVISQFQRP--STQFSLMQFSNKFQTHFTFEEFRR 208

Query: 427 KENVLAVIRNIRYMSGGTATGDAISFTVRNVF----GPIRESPNKNFLVIVTDGQSYD-- 480
             N L+++ ++  + G T T  AI   V  +F    G  R++     L+++TDG+     
Sbjct: 209 SSNPLSLLASVHQLQGFTYTATAIQNVVHRLFHASYGARRDA--AKILIVITDGKKEGDS 266

Query: 481 -DVQGPAAAAHDAGITIFSVGVAWA-----PLDDLKDMASKPKESHAFFTREFTGLEPI 533
            D +     A  AGI  +++GV  A        +L D+ASKP + H F   +F  L+ I
Sbjct: 267 LDYKDVIPMADAAGIIRYAIGVGLAFQNRNSWKELNDIASKPSQEHIFKVEDFDALKDI 325



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 43/170 (25%), Positives = 68/170 (40%), Gaps = 22/170 (12%)

Query: 165 DIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTS 224
           DI FLIDGS +I  R F    NFV   A++           L+Q S   +  F  + F  
Sbjct: 151 DIVFLIDGSGSISSRNFATMMNFVR--AVISQFQRPSTQFSLMQFSNKFQTHFTFEEFRR 208

Query: 225 AKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDD--- 281
           + + L  +  V    G + T  A+++   + F    G R+   K+++V  DG    D   
Sbjct: 209 SSNPLSLLASVHQLQGFTYTATAIQNVVHRLFHASYGARRDAAKILIVITDGKKEGDSLD 268

Query: 282 -------IEEAGIVAREFGVNVFIVS----------VAKPIPEELGMVQD 314
                   + AGI+    GV +   +           +KP  E +  V+D
Sbjct: 269 YKDVIPMADAAGIIRYAIGVGLAFQNRNSWKELNDIASKPSQEHIFKVED 318


>gi|148886654 polydom [Homo sapiens]
          Length = 3571

 Score = 76.3 bits (186), Expect = 7e-14
 Identities = 55/176 (31%), Positives = 84/176 (47%), Gaps = 10/176 (5%)

Query: 366 VNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQ----RTEFSF 421
           + + FL+D SSSVG+ NFR  L FV  +   F +     ++A V F+       R ++  
Sbjct: 82  LELVFLVDDSSSVGEVNFRSELMFVRKLLSDFPVVPTATRVAIVTFSSKNYVVPRVDYIS 141

Query: 422 TDYSTKEN---VLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRESPNKNFLVIVTDGQS 478
           T  + +     +L  I  I Y  GGT T  A     + +    RE+  K  + ++TDG S
Sbjct: 142 TRRARQHKCALLLQEIPAISYRGGGTYTKGAFQQAAQ-ILLHARENSTK-VVFLITDGYS 199

Query: 479 YDDVQGPAAAA-HDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPI 533
                 P AA+  D+G+ IF+ G+    + +L DMAS PKE H +    F   E +
Sbjct: 200 NGGDPRPIAASLRDSGVEIFTFGIWQGNIRELNDMASTPKEEHCYLLHSFEEFEAL 255



 Score = 38.1 bits (87), Expect = 0.021
 Identities = 32/147 (21%), Positives = 61/147 (41%), Gaps = 12/147 (8%)

Query: 163 KADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEH----PKIEFY 218
           + ++ FL+D S ++G+  F  +  FV K+     +      V +V  S      P++++ 
Sbjct: 81  RLELVFLVDDSSSVGEVNFRSELMFVRKLLSDFPVVPTATRVAIVTFSSKNYVVPRVDYI 140

Query: 219 LKNFTSAKDVLFAIKE---VGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFID 275
                        ++E   + +RGG + T  A +  AQ    +    R+   KVV +  D
Sbjct: 141 STRRARQHKCALLLQEIPAISYRGGGTYTKGAFQQAAQ----ILLHARENSTKVVFLITD 196

Query: 276 GWPS-DDIEEAGIVAREFGVNVFIVSV 301
           G+ +  D        R+ GV +F   +
Sbjct: 197 GYSNGGDPRPIAASLRDSGVEIFTFGI 223


>gi|224831239 integrin alpha M isoform 1 precursor [Homo sapiens]
          Length = 1153

 Score = 75.9 bits (185), Expect = 9e-14
 Identities = 55/178 (30%), Positives = 86/178 (48%), Gaps = 14/178 (7%)

Query: 367 NIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYST 426
           +IAFLIDGS S+   +FR M EFVS + +  + S      + +Q++ + R  F+F ++  
Sbjct: 150 DIAFLIDGSGSIIPHDFRRMKEFVSTVMEQLKKSK--TLFSLMQYSEEFRIHFTFKEFQN 207

Query: 427 KENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRESPNKN---FLVIVTDGQSYDDVQ 483
             N  ++++ I  + G T T   I   VR +F  I     KN    LV++TDG+ + D  
Sbjct: 208 NPNPRSLVKPITQLLGRTHTATGIRKVVRELFN-ITNGARKNAFKILVVITDGEKFGDPL 266

Query: 484 GPAAAAHDA---GITIFSVGVAWA-----PLDDLKDMASKPKESHAFFTREFTGLEPI 533
           G      +A   G+  + +GV  A        +L  +ASKP   H F    F  L+ I
Sbjct: 267 GYEDVIPEADREGVIRYVIGVGDAFRSEKSRQELNTIASKPPRDHVFQVNNFEALKTI 324



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 40/127 (31%), Positives = 59/127 (46%), Gaps = 2/127 (1%)

Query: 150 KKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQA 209
           +K PE   G     +DIAFLIDGS +I    F   K FV  V  M  +        L+Q 
Sbjct: 135 QKFPEALRGCPQEDSDIAFLIDGSGSIIPHDFRRMKEFVSTV--MEQLKKSKTLFSLMQY 192

Query: 210 SEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKV 269
           SE  +I F  K F +  +    +K +    G ++T   ++   ++ F +  G RK   K+
Sbjct: 193 SEEFRIHFTFKEFQNNPNPRSLVKPITQLLGRTHTATGIRKVVRELFNITNGARKNAFKI 252

Query: 270 VVVFIDG 276
           +VV  DG
Sbjct: 253 LVVITDG 259


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.404 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,607,567
Number of Sequences: 37866
Number of extensions: 911438
Number of successful extensions: 2392
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 50
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 1960
Number of HSP's gapped (non-prelim): 201
length of query: 550
length of database: 18,247,518
effective HSP length: 107
effective length of query: 443
effective length of database: 14,195,856
effective search space: 6288764208
effective search space used: 6288764208
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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