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Search of human proteins with 197927448
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|197927448 WD repeat domain 6 protein [Homo sapiens]
(1151 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|197927448 WD repeat domain 6 protein [Homo sapiens] 2382 0.0
gi|21536371 telomerase-associated protein 1 [Homo sapiens] 59 3e-08
gi|21071067 TBP-associated factor 5 [Homo sapiens] 58 6e-08
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 57 1e-07
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 57 1e-07
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 57 1e-07
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 54 1e-06
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 54 1e-06
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 52 2e-06
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 52 4e-06
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 52 4e-06
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 52 4e-06
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 51 6e-06
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 51 6e-06
gi|19913369 transducin beta-like 3 [Homo sapiens] 50 1e-05
gi|119120894 Dmx-like 2 [Homo sapiens] 50 2e-05
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is... 49 2e-05
gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i... 49 2e-05
gi|110815834 F-box and WD-40 domain protein 10 [Homo sapiens] 49 2e-05
gi|157694487 CMT1A duplicated region transcript 1 [Homo sapiens] 49 2e-05
gi|62234438 Notchless gene homolog isoform b [Homo sapiens] 49 2e-05
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 49 2e-05
gi|72534670 phospholipase A2-activating protein [Homo sapiens] 49 4e-05
gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)... 47 8e-05
gi|4759276 RNA, U3 small nucleolar interacting protein 2 [Homo s... 47 1e-04
gi|16554629 WD repeat domain 5 [Homo sapiens] 47 1e-04
gi|16554627 WD repeat domain 5 [Homo sapiens] 47 1e-04
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa... 45 3e-04
gi|157266266 WD repeat domain 86 [Homo sapiens] 45 4e-04
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 45 5e-04
>gi|197927448 WD repeat domain 6 protein [Homo sapiens]
Length = 1151
Score = 2382 bits (6172), Expect = 0.0
Identities = 1151/1151 (100%), Positives = 1151/1151 (100%)
Query: 1 MGSAARWEGSFSREFSSLLSRGCLSTSRIDMDALEDYVWPRATSELILLPVTGLECVGDR 60
MGSAARWEGSFSREFSSLLSRGCLSTSRIDMDALEDYVWPRATSELILLPVTGLECVGDR
Sbjct: 1 MGSAARWEGSFSREFSSLLSRGCLSTSRIDMDALEDYVWPRATSELILLPVTGLECVGDR 60
Query: 61 LLAGEGPDVLVYSLDFGGHLRMIKRVQNLLGHYLIHGFRVRPEPNGDLDLEAMVAVFGSK 120
LLAGEGPDVLVYSLDFGGHLRMIKRVQNLLGHYLIHGFRVRPEPNGDLDLEAMVAVFGSK
Sbjct: 61 LLAGEGPDVLVYSLDFGGHLRMIKRVQNLLGHYLIHGFRVRPEPNGDLDLEAMVAVFGSK 120
Query: 121 GLRVVKISWGQGHFWELWRSGLWNMSDWIWDARWLEGNIALALGHNSVVLYDPVVGCILQ 180
GLRVVKISWGQGHFWELWRSGLWNMSDWIWDARWLEGNIALALGHNSVVLYDPVVGCILQ
Sbjct: 121 GLRVVKISWGQGHFWELWRSGLWNMSDWIWDARWLEGNIALALGHNSVVLYDPVVGCILQ 180
Query: 181 EVPCTDRCTLSSACLIGDAWKELTIVAGAVSNQLLVWYPATALADNKPVAPDRRISGHVG 240
EVPCTDRCTLSSACLIGDAWKELTIVAGAVSNQLLVWYPATALADNKPVAPDRRISGHVG
Sbjct: 181 EVPCTDRCTLSSACLIGDAWKELTIVAGAVSNQLLVWYPATALADNKPVAPDRRISGHVG 240
Query: 241 IIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVQNIGHCFGHSARVWQVKLLENY 300
IIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVQNIGHCFGHSARVWQVKLLENY
Sbjct: 241 IIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVQNIGHCFGHSARVWQVKLLENY 300
Query: 301 LISAGEDCVCLVWSHEGEILQAFRGHQGRGIRAIAAHERQAWVITGGDDSGIRLWHLVGR 360
LISAGEDCVCLVWSHEGEILQAFRGHQGRGIRAIAAHERQAWVITGGDDSGIRLWHLVGR
Sbjct: 301 LISAGEDCVCLVWSHEGEILQAFRGHQGRGIRAIAAHERQAWVITGGDDSGIRLWHLVGR 360
Query: 361 GYRGLGVSALCFKSRSRPGTLKAVTLAGSWRLLAVTDTGALYLYDVEVKCWEQLLEDKHF 420
GYRGLGVSALCFKSRSRPGTLKAVTLAGSWRLLAVTDTGALYLYDVEVKCWEQLLEDKHF
Sbjct: 361 GYRGLGVSALCFKSRSRPGTLKAVTLAGSWRLLAVTDTGALYLYDVEVKCWEQLLEDKHF 420
Query: 421 QSYCLLEAAPGPEGFGLCAMANGEGRVKVVPINTPTAAVDQTLFPGKVHSLSWALRGYEE 480
QSYCLLEAAPGPEGFGLCAMANGEGRVKVVPINTPTAAVDQTLFPGKVHSLSWALRGYEE
Sbjct: 421 QSYCLLEAAPGPEGFGLCAMANGEGRVKVVPINTPTAAVDQTLFPGKVHSLSWALRGYEE 480
Query: 481 LLLLASGPGGVVACLEISAAPSGKAIFVKERCRYLLPPSKQRWHTCSAFLPPGDFLVCGD 540
LLLLASGPGGVVACLEISAAPSGKAIFVKERCRYLLPPSKQRWHTCSAFLPPGDFLVCGD
Sbjct: 481 LLLLASGPGGVVACLEISAAPSGKAIFVKERCRYLLPPSKQRWHTCSAFLPPGDFLVCGD 540
Query: 541 RRGSVLLFPSRPGLLKDPGVGGKARAGAGAPVVGSGSSGGGNAFTGLGPVSTLPSLHGKQ 600
RRGSVLLFPSRPGLLKDPGVGGKARAGAGAPVVGSGSSGGGNAFTGLGPVSTLPSLHGKQ
Sbjct: 541 RRGSVLLFPSRPGLLKDPGVGGKARAGAGAPVVGSGSSGGGNAFTGLGPVSTLPSLHGKQ 600
Query: 601 GVTSVTCHGGYVYTTGRDGAYYQLFVRDGQLQPVLRQKSCRGMNWLAGLRIVPDGSMVIL 660
GVTSVTCHGGYVYTTGRDGAYYQLFVRDGQLQPVLRQKSCRGMNWLAGLRIVPDGSMVIL
Sbjct: 601 GVTSVTCHGGYVYTTGRDGAYYQLFVRDGQLQPVLRQKSCRGMNWLAGLRIVPDGSMVIL 660
Query: 661 GFHANEFVVWNPRSHEKLHIVNCGGGHRSWAFSDTEAAMAFAYLKDGDVMLYRALGGCTR 720
GFHANEFVVWNPRSHEKLHIVNCGGGHRSWAFSDTEAAMAFAYLKDGDVMLYRALGGCTR
Sbjct: 661 GFHANEFVVWNPRSHEKLHIVNCGGGHRSWAFSDTEAAMAFAYLKDGDVMLYRALGGCTR 720
Query: 721 PHVILREGLHGREITCVKRVGTITLGPEYGVPSFMQPDDLEPGSEGPDLTDIVITCSEDT 780
PHVILREGLHGREITCVKRVGTITLGPEYGVPSFMQPDDLEPGSEGPDLTDIVITCSEDT
Sbjct: 721 PHVILREGLHGREITCVKRVGTITLGPEYGVPSFMQPDDLEPGSEGPDLTDIVITCSEDT 780
Query: 781 TVCVLALPTTTGSAHALTAVCNHISSVRAVAVWGIGTPGGPQDPQPGLTAHVVSAGGRAE 840
TVCVLALPTTTGSAHALTAVCNHISSVRAVAVWGIGTPGGPQDPQPGLTAHVVSAGGRAE
Sbjct: 781 TVCVLALPTTTGSAHALTAVCNHISSVRAVAVWGIGTPGGPQDPQPGLTAHVVSAGGRAE 840
Query: 841 MHCFSIMVTPDPSTPSRLACHVMHLSSHRLDEYWDRQRNRHRMVKVDPETRYMSLAVCEL 900
MHCFSIMVTPDPSTPSRLACHVMHLSSHRLDEYWDRQRNRHRMVKVDPETRYMSLAVCEL
Sbjct: 841 MHCFSIMVTPDPSTPSRLACHVMHLSSHRLDEYWDRQRNRHRMVKVDPETRYMSLAVCEL 900
Query: 901 DQPGLGPLVAAACSDGAVRLFLLQDSGRILQLLAETFHHKRCVLKVHSFTHEAPNQRRRL 960
DQPGLGPLVAAACSDGAVRLFLLQDSGRILQLLAETFHHKRCVLKVHSFTHEAPNQRRRL
Sbjct: 901 DQPGLGPLVAAACSDGAVRLFLLQDSGRILQLLAETFHHKRCVLKVHSFTHEAPNQRRRL 960
Query: 961 LLCSAATDGSLAFWDLTTMLDHDSTVLEPPVDPGLPYRLGTPSLTLQAHSCGINSLHTLP 1020
LLCSAATDGSLAFWDLTTMLDHDSTVLEPPVDPGLPYRLGTPSLTLQAHSCGINSLHTLP
Sbjct: 961 LLCSAATDGSLAFWDLTTMLDHDSTVLEPPVDPGLPYRLGTPSLTLQAHSCGINSLHTLP 1020
Query: 1021 TREGHHLVASGSEDGSLHVFVLAVEMLQLEEAVGEAGLVPQLRVLEEYSVPCAHAAHVTG 1080
TREGHHLVASGSEDGSLHVFVLAVEMLQLEEAVGEAGLVPQLRVLEEYSVPCAHAAHVTG
Sbjct: 1021 TREGHHLVASGSEDGSLHVFVLAVEMLQLEEAVGEAGLVPQLRVLEEYSVPCAHAAHVTG 1080
Query: 1081 LKILSPSIMVSASIDQRLTFWRLGHGEPTFMNSTVFHVPDVADMDCWPVSPEFGHRCALG 1140
LKILSPSIMVSASIDQRLTFWRLGHGEPTFMNSTVFHVPDVADMDCWPVSPEFGHRCALG
Sbjct: 1081 LKILSPSIMVSASIDQRLTFWRLGHGEPTFMNSTVFHVPDVADMDCWPVSPEFGHRCALG 1140
Query: 1141 GQGLEVYNWYD 1151
GQGLEVYNWYD
Sbjct: 1141 GQGLEVYNWYD 1151
>gi|21536371 telomerase-associated protein 1 [Homo sapiens]
Length = 2627
Score = 58.9 bits (141), Expect = 3e-08
Identities = 111/476 (23%), Positives = 176/476 (36%), Gaps = 109/476 (22%)
Query: 61 LLAGEGPDVLVYSLDFG---GHLRMIKRVQNLLGHYLIHGFRVRPEPNGDLDLEAMVAV- 116
L AGE V V+S G GHL + L V P+GD VAV
Sbjct: 1900 LTAGEDGKVQVWSGSLGRPRGHLGSLS---------LSPALSVALSPDGD-----RVAVG 1945
Query: 117 FGSKGLRVVKISWG----QGHFWELWRSGLWNMSDWIWDARWLEGNIALALGHNSVVLYD 172
+ + G+R+ KIS G QG ++ S L WL + ++ + +
Sbjct: 1946 YRADGIRIYKISSGSQGAQGQALDVAVSAL----------AWLSPKVLVSGAEDGSLQGW 1995
Query: 173 PVVGCILQEVPCTDRCTLSSACLIGDAWKELTIVAGAVSNQLLVWYPATAL-----ADNK 227
+ C LQ + R ++G A + + + + + +W P L A++
Sbjct: 1996 ALKECSLQSLWLLSRFQKP---VLGLATSQELLASASEDFTVQLW-PRQLLTRPHKAEDF 2051
Query: 228 PVAPDRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDLRVP------------- 274
P + R GH G + S+ G LAT DRS+ W V + P
Sbjct: 2052 PCGTELR--GHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDW 2109
Query: 275 -----------------GGRV--------QNIGHCFGHSARVWQVKLLENYLISAGEDCV 309
G V Q +G GH + V V +E +++S D
Sbjct: 2110 VTGCAWTKDNLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEEHVVSVSRDGT 2169
Query: 310 CLVWSHEGEILQAFRGHQGRGIRAIAAHERQA--------WVITGGDDSGIRLWH--LVG 359
VW H+G L + H G AA E +A V+T G D RLWH LV
Sbjct: 2170 LKVWDHQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVC 2229
Query: 360 RGYRGLGVSALCFKSRSRPGTLKAVTLA-GSWRLLAVTDTGALYLYDVEVKCWEQLLEDK 418
+ + LG S G ++A ++ S +L ++ G++ L+ V + + +
Sbjct: 2230 QTHTLLGHS----------GPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPR- 2278
Query: 419 HFQSYCLLEAAPGPEGFGLCAMANGEGRVKVVPINTPTAAVDQTLFPGKVHSLSWA 474
S + A P+G +MA + + + AV PG + +L W+
Sbjct: 2279 --SSAAVTAVAWAPDG----SMAVSGNQAGELILWQEAKAVATAQAPGHIGALIWS 2328
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 57.8 bits (138), Expect = 6e-08
Identities = 48/188 (25%), Positives = 81/188 (43%), Gaps = 20/188 (10%)
Query: 223 LADNKPVAPDRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVQNIG 282
+ D K + + + GH G ++ S+ + L ++SED +VR+W + G
Sbjct: 527 IMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYK---- 582
Query: 283 HCFGHSARVW--QVKLLENYLISAGEDCVCLVWSHEG-EILQAFRGHQGRGIRAIAAHER 339
GH+ VW Q Y +S G D V +W+ + + L+ F GH + H
Sbjct: 583 ---GHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLA-DVNCTRFHPN 638
Query: 340 QAWVITGGDDSGIRLWHLVGRGYRGLGVSALCFKSRSRPGTLKAVTLAGSWRLLAVTDT- 398
+V TG D +RLW ++ G F G + ++T + + R LA T
Sbjct: 639 SNYVATGSADRTVRLWDVLN------GNCVRIFTGHK--GPIHSLTFSPNGRFLATGATD 690
Query: 399 GALYLYDV 406
G + L+D+
Sbjct: 691 GRVLLWDI 698
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 57.0 bits (136), Expect = 1e-07
Identities = 58/231 (25%), Positives = 97/231 (41%), Gaps = 34/231 (14%)
Query: 138 WRSGLWNM---------SDWIWDARWLEGNIALALGHNSVVLYDPVVGCILQEVPCTDRC 188
WR G N+ S ++ ++ + I L NS+ ++D + C
Sbjct: 223 WRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKT------SLECLKVL 276
Query: 189 TLSSACLIGDAWKELTIVAGAVSNQLLVWYPATALADNKPVAPDRRISGHVGIIFSMSYL 248
T + ++ + E IV G+ + + VW T N + H + + +
Sbjct: 277 TGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIH-------HNEAVLHLRF- 328
Query: 249 ESKGLLATASEDRSVRIWKVGDLR-VPGGRVQNIGHCFGHSARVWQVKLLENYLISAGED 307
S GL+ T S+DRS+ +W + + RV GH A V V + Y++SA D
Sbjct: 329 -SNGLMVTCSKDRSIAVWDMASATDITLRRV-----LVGHRAAVNVVDFDDKYIVSASGD 382
Query: 308 CVCLVWSHEG-EILQAFRGHQGRGIRAIAAHERQAWVITGGDDSGIRLWHL 357
VWS E ++ GH+ RGI + +R V++G D+ IRLW +
Sbjct: 383 RTIKVWSTSTCEFVRTLNGHK-RGIACLQYRDR--LVVSGSSDNTIRLWDI 430
Score = 32.0 bits (71), Expect = 3.5
Identities = 27/124 (21%), Positives = 58/124 (46%), Gaps = 16/124 (12%)
Query: 193 ACLIGDAWKELTIVAGAVSNQLLVWYPATALADNKPVAPDRRISGHVGIIFSMSYLESKG 252
ACL +++ +V+G+ N + +W D + A R + GH ++ + + +
Sbjct: 407 ACL---QYRDRLVVSGSSDNTIRLW-------DIECGACLRVLEGHEELVRCIRFDNKR- 455
Query: 253 LLATASEDRSVRIWKVG---DLRVPGGRVQNIGHCFGHSARVWQVKLLENYLISAGEDCV 309
+ + + D +++W + D R P + + HS RV++++ E +IS+ D
Sbjct: 456 -IVSGAYDGKIKVWDLQAALDPRAPASTLC-LRTLVEHSGRVFRLQFDEFQIISSSHDDT 513
Query: 310 CLVW 313
L+W
Sbjct: 514 ILIW 517
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 57.0 bits (136), Expect = 1e-07
Identities = 58/231 (25%), Positives = 97/231 (41%), Gaps = 34/231 (14%)
Query: 138 WRSGLWNM---------SDWIWDARWLEGNIALALGHNSVVLYDPVVGCILQEVPCTDRC 188
WR G N+ S ++ ++ + I L NS+ ++D + C
Sbjct: 189 WRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKT------SLECLKVL 242
Query: 189 TLSSACLIGDAWKELTIVAGAVSNQLLVWYPATALADNKPVAPDRRISGHVGIIFSMSYL 248
T + ++ + E IV G+ + + VW T N + H + + +
Sbjct: 243 TGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIH-------HNEAVLHLRF- 294
Query: 249 ESKGLLATASEDRSVRIWKVGDLR-VPGGRVQNIGHCFGHSARVWQVKLLENYLISAGED 307
S GL+ T S+DRS+ +W + + RV GH A V V + Y++SA D
Sbjct: 295 -SNGLMVTCSKDRSIAVWDMASATDITLRRV-----LVGHRAAVNVVDFDDKYIVSASGD 348
Query: 308 CVCLVWSHEG-EILQAFRGHQGRGIRAIAAHERQAWVITGGDDSGIRLWHL 357
VWS E ++ GH+ RGI + +R V++G D+ IRLW +
Sbjct: 349 RTIKVWSTSTCEFVRTLNGHK-RGIACLQYRDR--LVVSGSSDNTIRLWDI 396
Score = 32.0 bits (71), Expect = 3.5
Identities = 27/124 (21%), Positives = 58/124 (46%), Gaps = 16/124 (12%)
Query: 193 ACLIGDAWKELTIVAGAVSNQLLVWYPATALADNKPVAPDRRISGHVGIIFSMSYLESKG 252
ACL +++ +V+G+ N + +W D + A R + GH ++ + + +
Sbjct: 373 ACL---QYRDRLVVSGSSDNTIRLW-------DIECGACLRVLEGHEELVRCIRFDNKR- 421
Query: 253 LLATASEDRSVRIWKVG---DLRVPGGRVQNIGHCFGHSARVWQVKLLENYLISAGEDCV 309
+ + + D +++W + D R P + + HS RV++++ E +IS+ D
Sbjct: 422 -IVSGAYDGKIKVWDLQAALDPRAPASTLC-LRTLVEHSGRVFRLQFDEFQIISSSHDDT 479
Query: 310 CLVW 313
L+W
Sbjct: 480 ILIW 483
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 57.0 bits (136), Expect = 1e-07
Identities = 58/231 (25%), Positives = 97/231 (41%), Gaps = 34/231 (14%)
Query: 138 WRSGLWNM---------SDWIWDARWLEGNIALALGHNSVVLYDPVVGCILQEVPCTDRC 188
WR G N+ S ++ ++ + I L NS+ ++D + C
Sbjct: 210 WRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKT------SLECLKVL 263
Query: 189 TLSSACLIGDAWKELTIVAGAVSNQLLVWYPATALADNKPVAPDRRISGHVGIIFSMSYL 248
T + ++ + E IV G+ + + VW T N + H + + +
Sbjct: 264 TGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIH-------HNEAVLHLRF- 315
Query: 249 ESKGLLATASEDRSVRIWKVGDLR-VPGGRVQNIGHCFGHSARVWQVKLLENYLISAGED 307
S GL+ T S+DRS+ +W + + RV GH A V V + Y++SA D
Sbjct: 316 -SNGLMVTCSKDRSIAVWDMASATDITLRRV-----LVGHRAAVNVVDFDDKYIVSASGD 369
Query: 308 CVCLVWSHEG-EILQAFRGHQGRGIRAIAAHERQAWVITGGDDSGIRLWHL 357
VWS E ++ GH+ RGI + +R V++G D+ IRLW +
Sbjct: 370 RTIKVWSTSTCEFVRTLNGHK-RGIACLQYRDR--LVVSGSSDNTIRLWDI 417
Score = 32.0 bits (71), Expect = 3.5
Identities = 27/124 (21%), Positives = 58/124 (46%), Gaps = 16/124 (12%)
Query: 193 ACLIGDAWKELTIVAGAVSNQLLVWYPATALADNKPVAPDRRISGHVGIIFSMSYLESKG 252
ACL +++ +V+G+ N + +W D + A R + GH ++ + + +
Sbjct: 394 ACL---QYRDRLVVSGSSDNTIRLW-------DIECGACLRVLEGHEELVRCIRFDNKR- 442
Query: 253 LLATASEDRSVRIWKVG---DLRVPGGRVQNIGHCFGHSARVWQVKLLENYLISAGEDCV 309
+ + + D +++W + D R P + + HS RV++++ E +IS+ D
Sbjct: 443 -IVSGAYDGKIKVWDLQAALDPRAPASTLC-LRTLVEHSGRVFRLQFDEFQIISSSHDDT 500
Query: 310 CLVW 313
L+W
Sbjct: 501 ILIW 504
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 53.5 bits (127), Expect = 1e-06
Identities = 53/218 (24%), Positives = 84/218 (38%), Gaps = 56/218 (25%)
Query: 179 LQEVPCTDRCTLSSACLIGDAWKELTIVAGAVSNQLLVWYPATALADNKPVAPDRRISGH 238
LQ + C + CL D K IV+G N + +W D + R ++GH
Sbjct: 257 LQRIHCRSETSKGVYCLQYDDQK---IVSGLRDNTIKIW-------DKNTLECKRILTGH 306
Query: 239 VGIIFSMSYLE--------------------------------------SKGLLATASED 260
G + + Y E + G++ T S+D
Sbjct: 307 TGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKD 366
Query: 261 RSVRIWKVGDLRVPGGRVQNIGHCFGHSARVWQVKLLENYLISAGEDCVCLVWSHEG-EI 319
RS+ +W D+ P + GH A V V + Y++SA D VW+ E
Sbjct: 367 RSIAVW---DMASPTD-ITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEF 422
Query: 320 LQAFRGHQGRGIRAIAAHERQAWVITGGDDSGIRLWHL 357
++ GH+ RGI + +R V++G D+ IRLW +
Sbjct: 423 VRTLNGHK-RGIACLQYRDR--LVVSGSSDNTIRLWDI 457
Score = 33.5 bits (75), Expect = 1.2
Identities = 27/124 (21%), Positives = 59/124 (47%), Gaps = 16/124 (12%)
Query: 193 ACLIGDAWKELTIVAGAVSNQLLVWYPATALADNKPVAPDRRISGHVGIIFSMSYLESKG 252
ACL +++ +V+G+ N + +W D + A R + GH ++ + + +
Sbjct: 434 ACL---QYRDRLVVSGSSDNTIRLW-------DIECGACLRVLEGHEELVRCIRFDNKR- 482
Query: 253 LLATASEDRSVRIWKVG---DLRVPGGRVQNIGHCFGHSARVWQVKLLENYLISAGEDCV 309
+ + + D +++W + D R P G + + HS RV++++ E ++S+ D
Sbjct: 483 -IVSGAYDGKIKVWDLVAALDPRAPAGTLC-LRTLVEHSGRVFRLQFDEFQIVSSSHDDT 540
Query: 310 CLVW 313
L+W
Sbjct: 541 ILIW 544
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 53.5 bits (127), Expect = 1e-06
Identities = 53/218 (24%), Positives = 84/218 (38%), Gaps = 56/218 (25%)
Query: 179 LQEVPCTDRCTLSSACLIGDAWKELTIVAGAVSNQLLVWYPATALADNKPVAPDRRISGH 238
LQ + C + CL D K IV+G N + +W D + R ++GH
Sbjct: 293 LQRIHCRSETSKGVYCLQYDDQK---IVSGLRDNTIKIW-------DKNTLECKRILTGH 342
Query: 239 VGIIFSMSYLE--------------------------------------SKGLLATASED 260
G + + Y E + G++ T S+D
Sbjct: 343 TGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKD 402
Query: 261 RSVRIWKVGDLRVPGGRVQNIGHCFGHSARVWQVKLLENYLISAGEDCVCLVWSHEG-EI 319
RS+ +W D+ P + GH A V V + Y++SA D VW+ E
Sbjct: 403 RSIAVW---DMASPTD-ITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEF 458
Query: 320 LQAFRGHQGRGIRAIAAHERQAWVITGGDDSGIRLWHL 357
++ GH+ RGI + +R V++G D+ IRLW +
Sbjct: 459 VRTLNGHK-RGIACLQYRDR--LVVSGSSDNTIRLWDI 493
Score = 33.5 bits (75), Expect = 1.2
Identities = 27/124 (21%), Positives = 59/124 (47%), Gaps = 16/124 (12%)
Query: 193 ACLIGDAWKELTIVAGAVSNQLLVWYPATALADNKPVAPDRRISGHVGIIFSMSYLESKG 252
ACL +++ +V+G+ N + +W D + A R + GH ++ + + +
Sbjct: 470 ACL---QYRDRLVVSGSSDNTIRLW-------DIECGACLRVLEGHEELVRCIRFDNKR- 518
Query: 253 LLATASEDRSVRIWKVG---DLRVPGGRVQNIGHCFGHSARVWQVKLLENYLISAGEDCV 309
+ + + D +++W + D R P G + + HS RV++++ E ++S+ D
Sbjct: 519 -IVSGAYDGKIKVWDLVAALDPRAPAGTLC-LRTLVEHSGRVFRLQFDEFQIVSSSHDDT 576
Query: 310 CLVW 313
L+W
Sbjct: 577 ILIW 580
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 52.4 bits (124), Expect = 2e-06
Identities = 38/131 (29%), Positives = 55/131 (41%), Gaps = 9/131 (6%)
Query: 230 APDRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVQNIGHCFGHSA 289
AP +SGH G ++ + + LA+A DR + +W V G N GHS
Sbjct: 57 APIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNV------YGDCDNYATLKGHSG 110
Query: 290 RVWQVKLLE--NYLISAGEDCVCLVWSHE-GEILQAFRGHQGRGIRAIAAHERQAWVITG 346
V ++ + L SA D VW E GE ++ +GH A V TG
Sbjct: 111 AVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTG 170
Query: 347 GDDSGIRLWHL 357
DD ++LW +
Sbjct: 171 SDDGTVKLWDI 181
Score = 41.2 bits (95), Expect = 0.006
Identities = 53/218 (24%), Positives = 87/218 (39%), Gaps = 54/218 (24%)
Query: 907 PLVAAACSDGAVRLFLLQDSGRILQLLAETFHHKRCVLKVHSFTHEAPNQRRRLLLCSAA 966
P + S G RL LL + A H V+++H T + +L SA+
Sbjct: 76 PNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGS-------MLFSAS 128
Query: 967 TDGSLAFWDLTTMLDHDSTVLEPPVDPGLPYRLGTPSLTLQAHSCGINSLHTLPTREGHH 1026
TD ++A WD T G L+ H+ +NS + P R G
Sbjct: 129 TDKTVAVWDSET---------------------GERVKRLKGHTSFVNSCY--PARRGPQ 165
Query: 1027 LVASGSEDGSLHVF----------------VLAVEMLQLEEAVGEAGLVPQLRVLE---- 1066
LV +GS+DG++ ++ VLAV + + G+ ++V +
Sbjct: 166 LVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQN 225
Query: 1067 --EYSVPCAHAAHVTGLKILSP-SIMVSASIDQRLTFW 1101
Y++ HA VTGL + S S ++S ++D + W
Sbjct: 226 KLTYTMR-GHADSVTGLSLSSEGSYLLSNAMDNTVRVW 262
Score = 32.3 bits (72), Expect = 2.7
Identities = 40/153 (26%), Positives = 60/153 (39%), Gaps = 20/153 (13%)
Query: 205 IVAGAVSNQLLVWYPATALADNKPVAPDRRISGHVGIIFSMSYLESKGLLATASEDRSVR 264
I++G + N + VW L NK R GH + +S L + + D +VR
Sbjct: 208 IISGGIDNDIKVW----DLRQNKLTYTMR---GHADSVTGLSLSSEGSYLLSNAMDNTVR 260
Query: 265 IWKVGDLRVPGGRVQNIGHCFGHSARVWQVKLL------ENYLISAGE-DCVCLVW-SHE 316
+W V P R I F + ++ LL + I+AG D VW +
Sbjct: 261 VWDVRPF-APKERCVKI---FQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTS 316
Query: 317 GEILQAFRGHQGRGIRAIAAHERQAWVITGGDD 349
IL GH G I +A H + +I+ D
Sbjct: 317 RRILYKLPGHAG-SINEVAFHPDEPIIISASSD 348
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 51.6 bits (122), Expect = 4e-06
Identities = 39/159 (24%), Positives = 67/159 (42%), Gaps = 27/159 (16%)
Query: 205 IVAGAVSNQLLVWYPATALADNKPVAPDRRISGHVGIIFSMSYLESKGL-LATASEDRSV 263
+V+GA + VW P T + + GH ++S+ + G+ + + S D S+
Sbjct: 396 VVSGAYDFMVKVWDPETETCLHT-------LQGHTNRVYSLQF---DGIHVVSGSLDTSI 445
Query: 264 RIWKVGDLRVPGGRVQNIGHCF----GHSARVWQVKLLENYLISAGEDCVCLVWSHE-GE 318
R+W V G+C GH + ++L +N L+S D +W + G+
Sbjct: 446 RVWDV-----------ETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQ 494
Query: 319 ILQAFRGHQGRGIRAIAAHERQAWVITGGDDSGIRLWHL 357
LQ +G + +VIT DD ++LW L
Sbjct: 495 CLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDL 533
Score = 49.7 bits (117), Expect = 2e-05
Identities = 28/105 (26%), Positives = 55/105 (52%), Gaps = 11/105 (10%)
Query: 254 LATASEDRSVRIWKVGDLRVPGGRVQNIGHCFGHSARVWQVKLLENYLISAGEDCVCLVW 313
+ + S+D ++++W V G ++ + GH+ VW ++ +N +IS D VW
Sbjct: 276 IVSGSDDNTLKVWSA----VTGKCLRTL---VGHTGGVWSSQMRDNIIISGSTDRTLKVW 328
Query: 314 SHE-GEILQAFRGHQGRGIRAIAAHERQAWVITGGDDSGIRLWHL 357
+ E GE + GH +R + HE++ V++G D+ +R+W +
Sbjct: 329 NAETGECIHTLYGHTST-VRCMHLHEKR--VVSGSRDATLRVWDI 370
Score = 48.1 bits (113), Expect = 5e-05
Identities = 39/156 (25%), Positives = 68/156 (43%), Gaps = 28/156 (17%)
Query: 205 IVAGAVSNQLLVWYPATALADNKPVAPDRRISGHVGIIFSMSYLESKGLLATASEDRSVR 264
IV+G+ N L VW T R + GH G ++S ++ ++ + S DR+++
Sbjct: 276 IVSGSDDNTLKVWSAVTGKCL-------RTLVGHTGGVWSSQMRDN--IIISGSTDRTLK 326
Query: 265 IWKVGDLRVPGGRVQNIGHC----FGHSARVWQVKLLENYLISAGEDCVCLVWSHE-GEI 319
+W G C +GH++ V + L E ++S D VW E G+
Sbjct: 327 VWNA-----------ETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQC 375
Query: 320 LQAFRGHQGRGIRAIAAHERQAWVITGGDDSGIRLW 355
L GH +R + R+ V++G D +++W
Sbjct: 376 LHVLMGHVA-AVRCVQYDGRR--VVSGAYDFMVKVW 408
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 51.6 bits (122), Expect = 4e-06
Identities = 39/159 (24%), Positives = 67/159 (42%), Gaps = 27/159 (16%)
Query: 205 IVAGAVSNQLLVWYPATALADNKPVAPDRRISGHVGIIFSMSYLESKGL-LATASEDRSV 263
+V+GA + VW P T + + GH ++S+ + G+ + + S D S+
Sbjct: 514 VVSGAYDFMVKVWDPETETCLHT-------LQGHTNRVYSLQF---DGIHVVSGSLDTSI 563
Query: 264 RIWKVGDLRVPGGRVQNIGHCF----GHSARVWQVKLLENYLISAGEDCVCLVWSHE-GE 318
R+W V G+C GH + ++L +N L+S D +W + G+
Sbjct: 564 RVWDV-----------ETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQ 612
Query: 319 ILQAFRGHQGRGIRAIAAHERQAWVITGGDDSGIRLWHL 357
LQ +G + +VIT DD ++LW L
Sbjct: 613 CLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDL 651
Score = 49.7 bits (117), Expect = 2e-05
Identities = 28/105 (26%), Positives = 55/105 (52%), Gaps = 11/105 (10%)
Query: 254 LATASEDRSVRIWKVGDLRVPGGRVQNIGHCFGHSARVWQVKLLENYLISAGEDCVCLVW 313
+ + S+D ++++W V G ++ + GH+ VW ++ +N +IS D VW
Sbjct: 394 IVSGSDDNTLKVWSA----VTGKCLRTL---VGHTGGVWSSQMRDNIIISGSTDRTLKVW 446
Query: 314 SHE-GEILQAFRGHQGRGIRAIAAHERQAWVITGGDDSGIRLWHL 357
+ E GE + GH +R + HE++ V++G D+ +R+W +
Sbjct: 447 NAETGECIHTLYGHTST-VRCMHLHEKR--VVSGSRDATLRVWDI 488
Score = 48.1 bits (113), Expect = 5e-05
Identities = 39/156 (25%), Positives = 68/156 (43%), Gaps = 28/156 (17%)
Query: 205 IVAGAVSNQLLVWYPATALADNKPVAPDRRISGHVGIIFSMSYLESKGLLATASEDRSVR 264
IV+G+ N L VW T R + GH G ++S ++ ++ + S DR+++
Sbjct: 394 IVSGSDDNTLKVWSAVTGKCL-------RTLVGHTGGVWSSQMRDN--IIISGSTDRTLK 444
Query: 265 IWKVGDLRVPGGRVQNIGHC----FGHSARVWQVKLLENYLISAGEDCVCLVWSHE-GEI 319
+W G C +GH++ V + L E ++S D VW E G+
Sbjct: 445 VWNA-----------ETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQC 493
Query: 320 LQAFRGHQGRGIRAIAAHERQAWVITGGDDSGIRLW 355
L GH +R + R+ V++G D +++W
Sbjct: 494 LHVLMGHVA-AVRCVQYDGRR--VVSGAYDFMVKVW 526
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 51.6 bits (122), Expect = 4e-06
Identities = 39/159 (24%), Positives = 67/159 (42%), Gaps = 27/159 (16%)
Query: 205 IVAGAVSNQLLVWYPATALADNKPVAPDRRISGHVGIIFSMSYLESKGL-LATASEDRSV 263
+V+GA + VW P T + + GH ++S+ + G+ + + S D S+
Sbjct: 434 VVSGAYDFMVKVWDPETETCLHT-------LQGHTNRVYSLQF---DGIHVVSGSLDTSI 483
Query: 264 RIWKVGDLRVPGGRVQNIGHCF----GHSARVWQVKLLENYLISAGEDCVCLVWSHE-GE 318
R+W V G+C GH + ++L +N L+S D +W + G+
Sbjct: 484 RVWDV-----------ETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQ 532
Query: 319 ILQAFRGHQGRGIRAIAAHERQAWVITGGDDSGIRLWHL 357
LQ +G + +VIT DD ++LW L
Sbjct: 533 CLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDL 571
Score = 49.7 bits (117), Expect = 2e-05
Identities = 28/105 (26%), Positives = 55/105 (52%), Gaps = 11/105 (10%)
Query: 254 LATASEDRSVRIWKVGDLRVPGGRVQNIGHCFGHSARVWQVKLLENYLISAGEDCVCLVW 313
+ + S+D ++++W V G ++ + GH+ VW ++ +N +IS D VW
Sbjct: 314 IVSGSDDNTLKVWSA----VTGKCLRTL---VGHTGGVWSSQMRDNIIISGSTDRTLKVW 366
Query: 314 SHE-GEILQAFRGHQGRGIRAIAAHERQAWVITGGDDSGIRLWHL 357
+ E GE + GH +R + HE++ V++G D+ +R+W +
Sbjct: 367 NAETGECIHTLYGHTST-VRCMHLHEKR--VVSGSRDATLRVWDI 408
Score = 48.1 bits (113), Expect = 5e-05
Identities = 39/156 (25%), Positives = 68/156 (43%), Gaps = 28/156 (17%)
Query: 205 IVAGAVSNQLLVWYPATALADNKPVAPDRRISGHVGIIFSMSYLESKGLLATASEDRSVR 264
IV+G+ N L VW T R + GH G ++S ++ ++ + S DR+++
Sbjct: 314 IVSGSDDNTLKVWSAVTGKCL-------RTLVGHTGGVWSSQMRDN--IIISGSTDRTLK 364
Query: 265 IWKVGDLRVPGGRVQNIGHC----FGHSARVWQVKLLENYLISAGEDCVCLVWSHE-GEI 319
+W G C +GH++ V + L E ++S D VW E G+
Sbjct: 365 VWNA-----------ETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQC 413
Query: 320 LQAFRGHQGRGIRAIAAHERQAWVITGGDDSGIRLW 355
L GH +R + R+ V++G D +++W
Sbjct: 414 LHVLMGHVA-AVRCVQYDGRR--VVSGAYDFMVKVW 446
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 51.2 bits (121), Expect = 6e-06
Identities = 41/157 (26%), Positives = 69/157 (43%), Gaps = 14/157 (8%)
Query: 202 ELTIVAGAVSNQLLVWYPATALADNKPVAPDRRISGHVGIIFSMSYLESKGLLATASEDR 261
E IVAG+ S + VW D + R + GH I S+ + +A+ S+D
Sbjct: 75 EELIVAGSQSGSIRVW-------DLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDT 127
Query: 262 SVRIWKVGDLRVPGGRVQNIGHCFGHSARVWQVKLLENYLISAGEDCVCLVWS-HEGEIL 320
++++W D+R G + GH + R + +L SA +D +W G+++
Sbjct: 128 NIKLW---DIRRKGCVFRYRGH--SQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMM 182
Query: 321 QAFRGHQGRGIRAIAAHERQAWVITGGDDSGIRLWHL 357
F GH G + + H + + +G D IR W L
Sbjct: 183 SEFPGHTG-PVNVVEFHPNEYLLASGSSDRTIRFWDL 218
Score = 44.7 bits (104), Expect = 5e-04
Identities = 38/149 (25%), Positives = 67/149 (44%), Gaps = 16/149 (10%)
Query: 233 RRISGHVGIIFSMSYLESKG-LLATASEDRSVRIWKVGDLRVPGGRVQNIGHCFGHSARV 291
+ I H + S+ ++ G LLAT +D V +W + + I GH++ V
Sbjct: 14 QEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSI-------NKPNCIMSLTGHTSPV 66
Query: 292 WQVKL--LENYLISAGEDCVCLVWSHE-GEILQAFRGHQGRGIRAIAAHERQAWVITGGD 348
V+L E +++ + VW E +IL+ GH+ I ++ H +V +G
Sbjct: 67 ESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKA-NICSLDFHPYGEFVASGSQ 125
Query: 349 DSGIRLWHLVGRG----YRGLGVSALCFK 373
D+ I+LW + +G YRG + C +
Sbjct: 126 DTNIKLWDIRRKGCVFRYRGHSQAVRCLR 154
Score = 38.1 bits (87), Expect = 0.049
Identities = 38/202 (18%), Positives = 78/202 (38%), Gaps = 31/202 (15%)
Query: 235 ISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVQNIGHCFGHSARVWQV 294
++GH + S+ + L+ S+ S+R+W + ++ + GH A + +
Sbjct: 59 LTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKI-------LRTLMGHKANICSL 111
Query: 295 KL--LENYLISAGEDCVCLVWS--HEGEILQAFRGHQGRGIRAIAAHERQAWVITGGDDS 350
++ S +D +W +G + + +RGH + +R + W+ + DD
Sbjct: 112 DFHPYGEFVASGSQDTNIKLWDIRRKGCVFR-YRGH-SQAVRCLRFSPDGKWLASAADDH 169
Query: 351 GIRLWHLVGRGYRGLGVSALCFKSRSRPGTLKAVTLAGSWRLLAVTDTGALYLYDVEVKC 410
++LW L + + G + V + LLA + D ++
Sbjct: 170 TVKLWDLT--------AGKMMSEFPGHTGPVNVVEFHPNEYLLASGSS------DRTIRF 215
Query: 411 WEQLLEDKHFQSYCLLEAAPGP 432
W+ + FQ +E PGP
Sbjct: 216 WDL----EKFQVVSCIEGEPGP 233
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 51.2 bits (121), Expect = 6e-06
Identities = 33/124 (26%), Positives = 52/124 (41%), Gaps = 11/124 (8%)
Query: 235 ISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVQNIGHCFGHSARVWQV 294
+ GH G ++S +L L + SED S+R W +G N GH+ VW +
Sbjct: 338 LRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSF-------TNTVLYQGHAYPVWDL 390
Query: 295 KL--LENYLISAGEDCVCLVWSHEGEI-LQAFRGHQGRGIRAIAAHERQAWVITGGDDSG 351
+ Y S D +WS + L+ + GH + + H ++ TG D
Sbjct: 391 DISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLA-DVDCVKFHPNSNYLATGSTDKT 449
Query: 352 IRLW 355
+RLW
Sbjct: 450 VRLW 453
Score = 43.5 bits (101), Expect = 0.001
Identities = 34/130 (26%), Positives = 56/130 (43%), Gaps = 11/130 (8%)
Query: 231 PDRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVQNIGHCFGHSAR 290
P R +GH+ + + + + LAT S D++VR+W G V+ GH
Sbjct: 418 PLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQ----GNSVRLF---TGHRGP 470
Query: 291 VWQVKLLEN--YLISAGEDCVCLVWS-HEGEILQAFRGHQGRGIRAIAAHERQAWVITGG 347
V + N YL SAGED +W G + + RGH I ++ + +
Sbjct: 471 VLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTD-NITSLTFSPDSGLIASAS 529
Query: 348 DDSGIRLWHL 357
D+ +R+W +
Sbjct: 530 MDNSVRVWDI 539
Score = 35.8 bits (81), Expect = 0.24
Identities = 22/78 (28%), Positives = 38/78 (48%), Gaps = 5/78 (6%)
Query: 233 RRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGD----LRVPGGRVQNIGHCFGHS 288
+ + GH I S+++ GL+A+AS D SVR+W + + G + +G G
Sbjct: 504 KELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQM 563
Query: 289 ARVWQVKLLE-NYLISAG 305
+ V V+ + N L+ G
Sbjct: 564 SNVLSVQFMACNLLLVTG 581
>gi|19913369 transducin beta-like 3 [Homo sapiens]
Length = 808
Score = 50.1 bits (118), Expect = 1e-05
Identities = 35/141 (24%), Positives = 61/141 (43%), Gaps = 22/141 (15%)
Query: 235 ISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVQNIGHCFGHSARVWQV 294
+ GH I+ ++ L A+ ++D+SVRIW++ G+V + GH+ V V
Sbjct: 372 LHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMN----KAGQVMCVAQGSGHTHSVGTV 427
Query: 295 ---KLLENYLISAGEDCVCLVW------------SHEGEIL---QAFRGHQGRGIRAIAA 336
+L E++L++ +DC +W G IL Q + + I ++A
Sbjct: 428 CCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAI 487
Query: 337 HERQAWVITGGDDSGIRLWHL 357
+ TG D +LW L
Sbjct: 488 APNDKLLATGSQDRTAKLWAL 508
Score = 42.0 bits (97), Expect = 0.003
Identities = 44/195 (22%), Positives = 76/195 (38%), Gaps = 36/195 (18%)
Query: 173 PVVGCILQEVPCTDRCTLSSACLIGDAWKELTIVAGAVSNQLLVWYPATALADNKPVAPD 232
P G IL + T RC + A + + G+ +W AL + +
Sbjct: 462 PDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLW----ALPQCQLLGV- 516
Query: 233 RRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVQNIGHCFGHSARVW 292
SGH ++ + + +LATAS D ++++W + D + GH A V
Sbjct: 517 --FSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSC-------LKTFEGHDASVL 567
Query: 293 QVKLLE--NYLISAGEDCVCLVWSHEGEILQAFRGHQGRGIRAIAAHERQAW-------- 342
+V + L+S+G D + +W+ + +R + AHE + W
Sbjct: 568 KVAFVSRGTQLLSSGSDGLVKLWTIK----------NNECVRTLDAHEDKVWGLHCSRLD 617
Query: 343 --VITGGDDSGIRLW 355
+TG DS + LW
Sbjct: 618 DHALTGASDSRVILW 632
>gi|119120894 Dmx-like 2 [Homo sapiens]
Length = 3036
Score = 49.7 bits (117), Expect = 2e-05
Identities = 33/120 (27%), Positives = 60/120 (50%), Gaps = 7/120 (5%)
Query: 246 SYLESKGLLATA---SEDRSVRIWKVGDLRVPGGRVQNIGHCFGHSARVWQVKLLENYLI 302
+++ S L+AT+ +++R+V +W L PG + + C H A V Q + LI
Sbjct: 2859 AFITSSSLVATSGHSNDNRNVCLWDT--LISPGNSLIHGFTCHDHGATVLQYAPKQQLLI 2916
Query: 303 SAG-EDCVCLVWSHEGEILQAFRGHQGRGIRAIAAHERQAWVITGGDDSGIRLWHLVGRG 361
S G + VC+ + +++ F+ H I+A+A + + TG + I++W L G G
Sbjct: 2917 SGGRKGHVCIFDIRQRQLIHTFQAHDS-AIKALALDPYEEYFTTGSAEGNIKVWRLTGHG 2975
>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
isoform a [Homo sapiens]
Length = 353
Score = 49.3 bits (116), Expect = 2e-05
Identities = 55/216 (25%), Positives = 87/216 (40%), Gaps = 22/216 (10%)
Query: 147 DWIWDARWLEGNIALALGHNSVVLYDPVVGCILQEVPCTDRCTLSSACLIGDAWKELTIV 206
DW D R I + V+++D +E T CT AC + I
Sbjct: 70 DWCKDKR----RIVSSSQDGKVIVWDSFT--TNKEHAVTMPCTWVMACAYAPSG--CAIA 121
Query: 207 AGAVSNQLLVWYPATALADNKPVAPDRRISGHVGIIFSMSYLESKGLLATASEDRSVRIW 266
G + N+ V YP T + A + ++ H + + S+ S + TAS D + +W
Sbjct: 122 CGGLDNKCSV-YPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALW 180
Query: 267 KVGDLRVPGGRVQNIGHCFGHSARVWQVKLLE----NYLISAGEDCVCLVWS-HEGEILQ 321
V G++ H GH A V + L N +S G D +VW G+ +Q
Sbjct: 181 D-----VESGQLLQSFH--GHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQ 233
Query: 322 AFRGHQGRGIRAIAAHERQAWVITGGDDSGIRLWHL 357
AF H+ I ++ + +G DD+ RL+ L
Sbjct: 234 AFETHES-DINSVRYYPSGDAFASGSDDATCRLYDL 268
>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
isoform b [Homo sapiens]
Length = 395
Score = 49.3 bits (116), Expect = 2e-05
Identities = 55/216 (25%), Positives = 87/216 (40%), Gaps = 22/216 (10%)
Query: 147 DWIWDARWLEGNIALALGHNSVVLYDPVVGCILQEVPCTDRCTLSSACLIGDAWKELTIV 206
DW D R I + V+++D +E T CT AC + I
Sbjct: 112 DWCKDKR----RIVSSSQDGKVIVWDSFT--TNKEHAVTMPCTWVMACAYAPSG--CAIA 163
Query: 207 AGAVSNQLLVWYPATALADNKPVAPDRRISGHVGIIFSMSYLESKGLLATASEDRSVRIW 266
G + N+ V YP T + A + ++ H + + S+ S + TAS D + +W
Sbjct: 164 CGGLDNKCSV-YPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALW 222
Query: 267 KVGDLRVPGGRVQNIGHCFGHSARVWQVKLLE----NYLISAGEDCVCLVWS-HEGEILQ 321
V G++ H GH A V + L N +S G D +VW G+ +Q
Sbjct: 223 D-----VESGQLLQSFH--GHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQ 275
Query: 322 AFRGHQGRGIRAIAAHERQAWVITGGDDSGIRLWHL 357
AF H+ I ++ + +G DD+ RL+ L
Sbjct: 276 AFETHES-DINSVRYYPSGDAFASGSDDATCRLYDL 310
>gi|110815834 F-box and WD-40 domain protein 10 [Homo sapiens]
Length = 1051
Score = 49.3 bits (116), Expect = 2e-05
Identities = 43/184 (23%), Positives = 78/184 (42%), Gaps = 21/184 (11%)
Query: 237 GHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVQNIGHCFGHSARVWQVKL 296
GH G + ++ E + L + S D S+R W DL+ G + G GH + + L
Sbjct: 451 GHAGSVRALFLCEEENFLLSGSYDLSIRYW---DLK-SGVCTRIFG---GHQGTITCMDL 503
Query: 297 LENYLISAGEDCVCLVWSHE-GEILQAFRGHQGRGIRAIAAHERQAWVITGGDDSGIRLW 355
+N L+S G DC VW + G+ L+ FR +A ++++ + +++W
Sbjct: 504 CKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKD----PILATRINDTYIVSSCERGLVKVW 559
Query: 356 HLVGRGYRGLGVSALCFKSRSRPGTLKAVTLAGSWRLLAVTDTGALYLYDVEVKCWEQLL 415
H + ++ L G +K + W LL+ + G + + + K L+
Sbjct: 560 H--------IAMAQLVKTLSGHEGAVKCL-FFDQWHLLSGSTDGLVMAWSMVGKYERCLM 610
Query: 416 EDKH 419
KH
Sbjct: 611 AFKH 614
>gi|157694487 CMT1A duplicated region transcript 1 [Homo sapiens]
Length = 752
Score = 49.3 bits (116), Expect = 2e-05
Identities = 43/184 (23%), Positives = 78/184 (42%), Gaps = 21/184 (11%)
Query: 237 GHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVQNIGHCFGHSARVWQVKL 296
GH G + ++ E + L + S D S+R W DL+ G + G GH + + L
Sbjct: 451 GHAGSVRALFLCEEENFLLSGSYDLSIRYW---DLK-SGVCTRIFG---GHQGTITCMDL 503
Query: 297 LENYLISAGEDCVCLVWSHE-GEILQAFRGHQGRGIRAIAAHERQAWVITGGDDSGIRLW 355
+N L+S G DC VW + G+ L+ FR +A ++++ + +++W
Sbjct: 504 CKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKD----PILATRINDTYIVSSCERGLVKVW 559
Query: 356 HLVGRGYRGLGVSALCFKSRSRPGTLKAVTLAGSWRLLAVTDTGALYLYDVEVKCWEQLL 415
H + ++ L G +K + W LL+ + G + + + K L+
Sbjct: 560 H--------IAMAQLVKTLSGHEGAVKCL-FFDQWHLLSGSTDGLVMAWSMVGKYERCLM 610
Query: 416 EDKH 419
KH
Sbjct: 611 AFKH 614
>gi|62234438 Notchless gene homolog isoform b [Homo sapiens]
Length = 193
Score = 49.3 bits (116), Expect = 2e-05
Identities = 38/153 (24%), Positives = 67/153 (43%), Gaps = 15/153 (9%)
Query: 205 IVAGAVSNQLLVWYPATALADNKPVAPDRRISGHVGIIFSMSYLESKGLLATASEDRSVR 264
+V+G+ L +W PA D KP+ R++GH +I + + ++A+AS D+S++
Sbjct: 52 LVSGSDDFTLFLWSPAE---DKKPLT---RMTGHQALINQVLFSPDSRIVASASFDKSIK 105
Query: 265 IWKVGDLRVPGGRVQNIGHCFGHSARVWQV--KLLENYLISAGEDCVCLVWSHEGEILQA 322
+W G + + GH A V+Q+ L+S D VW + + L
Sbjct: 106 LW-------DGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAM 158
Query: 323 FRGHQGRGIRAIAAHERQAWVITGGDDSGIRLW 355
+ A+ V +GG D +R+W
Sbjct: 159 DLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 191
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 49.3 bits (116), Expect = 2e-05
Identities = 38/153 (24%), Positives = 67/153 (43%), Gaps = 15/153 (9%)
Query: 205 IVAGAVSNQLLVWYPATALADNKPVAPDRRISGHVGIIFSMSYLESKGLLATASEDRSVR 264
+V+G+ L +W PA D KP+ R++GH +I + + ++A+AS D+S++
Sbjct: 344 LVSGSDDFTLFLWSPAE---DKKPLT---RMTGHQALINQVLFSPDSRIVASASFDKSIK 397
Query: 265 IWKVGDLRVPGGRVQNIGHCFGHSARVWQV--KLLENYLISAGEDCVCLVWSHEGEILQA 322
+W G + + GH A V+Q+ L+S D VW + + L
Sbjct: 398 LW-------DGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAM 450
Query: 323 FRGHQGRGIRAIAAHERQAWVITGGDDSGIRLW 355
+ A+ V +GG D +R+W
Sbjct: 451 DLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 33.1 bits (74), Expect = 1.6
Identities = 29/132 (21%), Positives = 57/132 (43%), Gaps = 22/132 (16%)
Query: 148 WIWDARWLEGNIALALG--HNSVVLYDPVVGCILQEVPCTDRCTLSSACLIGDAWKELT- 204
W+ W LA G + ++L+DP G ++V T S + G +W+ L
Sbjct: 158 WVLSISWSPDGRKLASGCKNGQILLWDPSTG---KQVGRT--LAGHSKWITGLSWEPLHA 212
Query: 205 ------IVAGAVSNQLLVWYPATALADNKPVAPDRRISGHVGIIFSMSYLESKGLLATAS 258
+ + + + +W D +R ++GH + + + GLL +AS
Sbjct: 213 NPECRYVASSSKDGSVRIW-------DTTAGRCERILTGHTQSVTCLRW-GGDGLLYSAS 264
Query: 259 EDRSVRIWKVGD 270
+DR++++W+ D
Sbjct: 265 QDRTIKVWRAHD 276
Score = 31.2 bits (69), Expect = 5.9
Identities = 25/110 (22%), Positives = 48/110 (43%), Gaps = 17/110 (15%)
Query: 639 SCRG-MNWLAGLRIVPDGSMVILGFHANEFVVWNPRSHEKLHIVNCGGGHRSW------- 690
+C+G +W+ + PDG + G + ++W+P + ++ + GH W
Sbjct: 151 TCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQ--VGRTLAGHSKWITGLSWE 208
Query: 691 -AFSDTEAAMAFAYLKDGDVMLYRALGG-CTRPHVILREGLHGREITCVK 738
++ E + KDG V ++ G C R IL H + +TC++
Sbjct: 209 PLHANPECRYVASSSKDGSVRIWDTTAGRCER---ILTG--HTQSVTCLR 253
>gi|72534670 phospholipase A2-activating protein [Homo sapiens]
Length = 795
Score = 48.5 bits (114), Expect = 4e-05
Identities = 32/122 (26%), Positives = 55/122 (45%), Gaps = 11/122 (9%)
Query: 235 ISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVQNIGHCFGHSARVWQV 294
+ GH ++++ L +GL+ T S D++V++WK GR + GH V +
Sbjct: 147 LQGHTAAVWAVKILPEQGLMLTGSADKTVKLWK-------AGRCERT--FSGHEDCVRGL 197
Query: 295 KLL-ENYLISAGEDCVCLVWSHEGEILQAFRGHQGRGIRAIAAHERQAWVITGGDDSGIR 353
+L E +S D W GE L+ + GH I +I+ +T +D +R
Sbjct: 198 AILSETEFLSCANDASIRRWQITGECLEVYYGHTNY-IYSISVFPNCRDFVTTAEDRSLR 256
Query: 354 LW 355
+W
Sbjct: 257 IW 258
Score = 33.9 bits (76), Expect = 0.92
Identities = 15/34 (44%), Positives = 21/34 (61%)
Query: 237 GHVGIIFSMSYLESKGLLATASEDRSVRIWKVGD 270
GH I+S+S + T +EDRS+RIWK G+
Sbjct: 229 GHTNYIYSISVFPNCRDFVTTAEDRSLRIWKHGE 262
>gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)
[Homo sapiens]
Length = 906
Score = 47.4 bits (111), Expect = 8e-05
Identities = 28/103 (27%), Positives = 54/103 (52%), Gaps = 5/103 (4%)
Query: 255 ATASEDRSVRIWKVGDLRVPGGRVQNIGHCFGHSARVWQVKLLENYLISAGEDCVCLVWS 314
A+AS DR++++W++G P ++ GH G + + + YLIS +D + +W
Sbjct: 159 ASASLDRTIKVWQLGSSS-PNFTLE--GHEKGVNCIDYYSGGDKPYLISGADDRLVKIWD 215
Query: 315 HEGEI-LQAFRGHQGRGIRAIAAHERQAWVITGGDDSGIRLWH 356
++ + +Q GH + + + H +ITG +D +R+WH
Sbjct: 216 YQNKTCVQTLEGH-AQNVSCASFHPELPIIITGSEDGTVRIWH 257
Score = 34.3 bits (77), Expect = 0.70
Identities = 18/59 (30%), Positives = 32/59 (54%), Gaps = 2/59 (3%)
Query: 298 ENYLISAGEDCVCLVWSHEG-EILQAFRGHQGRGIRAIAAHERQAWVITGGDDSGIRLW 355
+N++++ +D V+++ E + F H IR IA H Q +++T DD I+LW
Sbjct: 69 KNWVVTGADDMQIRVFNYNTLERVHMFEAHSDY-IRCIAVHPTQPFILTSSDDMLIKLW 126
Score = 32.7 bits (73), Expect = 2.0
Identities = 22/70 (31%), Positives = 31/70 (44%), Gaps = 8/70 (11%)
Query: 287 HSARVWQVKLLENYLISAGEDCVCLVWSHEGEILQAFRGHQGRGIRAIAAHERQAWVITG 346
H W + L N G CV W+HE + L +RA R+ WV+TG
Sbjct: 24 HPTEPWMLASLYN-----GSVCV---WNHETQTLVKTFEVCDLPVRAAKFVARKNWVVTG 75
Query: 347 GDDSGIRLWH 356
DD IR+++
Sbjct: 76 ADDMQIRVFN 85
>gi|4759276 RNA, U3 small nucleolar interacting protein 2 [Homo
sapiens]
Length = 475
Score = 46.6 bits (109), Expect = 1e-04
Identities = 48/179 (26%), Positives = 73/179 (40%), Gaps = 14/179 (7%)
Query: 236 SGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVQNIGHCFGHSARVWQVK 295
+GH + +++ L + S DRSV++W V + V+ + FGH V +
Sbjct: 238 TGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAE----NSYVETL---FGHQDAVAALD 290
Query: 296 LL--ENYLISAGEDCVCLVWSHEGEILQAFRGHQGRGIRAIAAHERQAWVITGGDDSGIR 353
L E + + G D VW E F GHQG I I + +++G DD +
Sbjct: 291 ALSRECCVTAGGRDGTVRVWKIPEESQLVFYGHQG-SIDCIHLINEE-HMVSGADDGSVA 348
Query: 354 LWHLVGRGYRGLGVSALCFKSRSRPGTLKAVTLAGSWRLLAVTDTGALYLYDVEVKCWE 412
LW L + R L + R PG L+ S L TD A + V+ W+
Sbjct: 349 LWGLSKK--RPLALQREAHGLRGEPG-LEQPFWISSVAALLNTDLVATGSHSSCVRLWQ 404
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 46.6 bits (109), Expect = 1e-04
Identities = 35/146 (23%), Positives = 67/146 (45%), Gaps = 17/146 (11%)
Query: 219 PATALADNKP--VAPDRRI----SGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDLR 272
P+++ +KP V P+ + +GH + S+ + + LA++S D+ ++IW D
Sbjct: 19 PSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYD-- 76
Query: 273 VPGGRVQNI--GHCFGHSARVWQVKLLENYLISAGEDCVCLVWS-HEGEILQAFRGHQGR 329
G+ + GH G S W N L+SA +D +W G+ L+ +GH
Sbjct: 77 ---GKFEKTISGHKLGISDVAWSSD--SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNY 131
Query: 330 GIRAIAAHERQAWVITGGDDSGIRLW 355
+ + + +++G D +R+W
Sbjct: 132 -VFCCNFNPQSNLIVSGSFDESVRIW 156
Score = 36.6 bits (83), Expect = 0.14
Identities = 31/162 (19%), Positives = 63/162 (38%), Gaps = 38/162 (23%)
Query: 232 DRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGD---LRVPGGRVQNIGHC---- 284
++ ISGH I +++ LL +AS+D++++IW V L+ G + C
Sbjct: 80 EKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP 139
Query: 285 ---------FGHSARVWQVKLLE---------------------NYLISAGEDCVCLVW- 313
F S R+W VK + + ++S+ D +C +W
Sbjct: 140 QSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
Query: 314 SHEGEILQAFRGHQGRGIRAIAAHERQAWVITGGDDSGIRLW 355
+ G+ L+ + + +++ D+ ++LW
Sbjct: 200 TASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241
Score = 35.0 bits (79), Expect = 0.41
Identities = 33/166 (19%), Positives = 62/166 (37%), Gaps = 41/166 (24%)
Query: 233 RRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDLRV---------PGGRVQN--- 280
+ + GH +F ++ L+ + S D SVRIW V + P V
Sbjct: 123 KTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRD 182
Query: 281 ----IGHCFGHSARVWQ--------------------VKLLEN--YLISAGEDCVCLVWS 314
+ + R+W VK N Y+++A D +W
Sbjct: 183 GSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD 242
Query: 315 H-EGEILQAFRGHQGRGIRAIAAHERQA--WVITGGDDSGIRLWHL 357
+ +G+ L+ + GH+ A W+++G +D+ + +W+L
Sbjct: 243 YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 288
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 46.6 bits (109), Expect = 1e-04
Identities = 35/146 (23%), Positives = 67/146 (45%), Gaps = 17/146 (11%)
Query: 219 PATALADNKP--VAPDRRI----SGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDLR 272
P+++ +KP V P+ + +GH + S+ + + LA++S D+ ++IW D
Sbjct: 19 PSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYD-- 76
Query: 273 VPGGRVQNI--GHCFGHSARVWQVKLLENYLISAGEDCVCLVWS-HEGEILQAFRGHQGR 329
G+ + GH G S W N L+SA +D +W G+ L+ +GH
Sbjct: 77 ---GKFEKTISGHKLGISDVAWSSD--SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNY 131
Query: 330 GIRAIAAHERQAWVITGGDDSGIRLW 355
+ + + +++G D +R+W
Sbjct: 132 -VFCCNFNPQSNLIVSGSFDESVRIW 156
Score = 36.6 bits (83), Expect = 0.14
Identities = 31/162 (19%), Positives = 63/162 (38%), Gaps = 38/162 (23%)
Query: 232 DRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGD---LRVPGGRVQNIGHC---- 284
++ ISGH I +++ LL +AS+D++++IW V L+ G + C
Sbjct: 80 EKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP 139
Query: 285 ---------FGHSARVWQVKLLE---------------------NYLISAGEDCVCLVW- 313
F S R+W VK + + ++S+ D +C +W
Sbjct: 140 QSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
Query: 314 SHEGEILQAFRGHQGRGIRAIAAHERQAWVITGGDDSGIRLW 355
+ G+ L+ + + +++ D+ ++LW
Sbjct: 200 TASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241
Score = 35.0 bits (79), Expect = 0.41
Identities = 33/166 (19%), Positives = 62/166 (37%), Gaps = 41/166 (24%)
Query: 233 RRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDLRV---------PGGRVQN--- 280
+ + GH +F ++ L+ + S D SVRIW V + P V
Sbjct: 123 KTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRD 182
Query: 281 ----IGHCFGHSARVWQ--------------------VKLLEN--YLISAGEDCVCLVWS 314
+ + R+W VK N Y+++A D +W
Sbjct: 183 GSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD 242
Query: 315 H-EGEILQAFRGHQGRGIRAIAAHERQA--WVITGGDDSGIRLWHL 357
+ +G+ L+ + GH+ A W+++G +D+ + +W+L
Sbjct: 243 YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 288
>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
sapiens]
Length = 472
Score = 45.4 bits (106), Expect = 3e-04
Identities = 33/127 (25%), Positives = 55/127 (43%), Gaps = 13/127 (10%)
Query: 238 HVGIIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVQNIGHCF----GHSARVWQ 293
H I + + S L T+S D++++IW V G +N G C GH V
Sbjct: 272 HSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHT-----GEFRNCGACVTLMQGHEGSVSS 326
Query: 294 VKLLEN--YLISAGEDCVCLVWS-HEGEILQAFRGHQGRGIRAIAAHERQAWVITGGDDS 350
+ +LIS G D +W EG + +GH + +A + W+++ D
Sbjct: 327 CHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHND-WVMDVAISNNKKWILSASKDR 385
Query: 351 GIRLWHL 357
+RLW++
Sbjct: 386 TMRLWNI 392
Score = 32.7 bits (73), Expect = 2.0
Identities = 23/84 (27%), Positives = 39/84 (46%), Gaps = 9/84 (10%)
Query: 235 ISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVQNIGHCFGHSARVWQV 294
+ GH G + S + L + DR+V IW V + G R ++ GH+ V V
Sbjct: 317 MQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAE----GYRKLSLK---GHNDWVMDV 369
Query: 295 KLLEN--YLISAGEDCVCLVWSHE 316
+ N +++SA +D +W+ E
Sbjct: 370 AISNNKKWILSASKDRTMRLWNIE 393
>gi|157266266 WD repeat domain 86 [Homo sapiens]
Length = 376
Score = 45.1 bits (105), Expect = 4e-04
Identities = 51/215 (23%), Positives = 76/215 (35%), Gaps = 26/215 (12%)
Query: 233 RRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVQNIGHCF----GHS 288
R + H G I +S L T SED + R+W D G C GH
Sbjct: 9 RVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTAD-----------GQCCALLQGHE 57
Query: 289 ARVWQVKLLENYLISAGEDCVCLVWS-HEGEILQAFRGHQGRGIRAIAAHERQAWVITGG 347
+ V +L + + DC W G+ LQ +RGH R + A+ + + +
Sbjct: 58 SYVTFCQLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQ---LFSSS 114
Query: 348 DDSGIRLWHL-------VGRGYRGLGVSALCFKSRSRPGTLKAVTLAGSWRLLAVTDTGA 400
D R+W + RG+R ++ P T A A L+ + G
Sbjct: 115 YDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGT 174
Query: 401 LYLYDVEVKCWEQLLEDKHFQSYCLLEAAPGPEGF 435
++ V C Q L CL+ PG F
Sbjct: 175 AKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAF 209
Score = 33.9 bits (76), Expect = 0.92
Identities = 32/117 (27%), Positives = 49/117 (41%), Gaps = 21/117 (17%)
Query: 253 LLATASEDRSVRIWKVGDLRVPGGRVQNIGHCF----GHSARVWQVKLLENYLIS-AGED 307
L+ + S DR+V+ W + + G C H V +K L + +G+
Sbjct: 247 LVYSGSADRTVKCW-----------LADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDA 295
Query: 308 CVCLVWSHEGEILQAFRGHQGRGIRAIAAHERQAWVITGGDDSGIRLWHLVGRGYRG 364
C + GE+ + FRGH I I H + + T D +RLW + RG RG
Sbjct: 296 CARAFDAQSGELRRVFRGHTFI-INCIQVHGQVLY--TASHDGALRLWDV--RGLRG 347
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 44.7 bits (104), Expect = 5e-04
Identities = 29/127 (22%), Positives = 58/127 (45%), Gaps = 11/127 (8%)
Query: 232 DRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVQNIGHCFGHSARV 291
+R + GH + +S+ S LLA+ S D ++++W + I GH V
Sbjct: 143 ERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGF-------ECIRTMHGHDHNV 195
Query: 292 WQVKLLEN--YLISAGEDCVCLVWS-HEGEILQAFRGHQGRGIRAIAAHERQAWVITGGD 348
V ++ N +++SA D +W G ++ F GH+ +R + ++ + + +
Sbjct: 196 SSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHR-EWVRMVRPNQDGTLIASCSN 254
Query: 349 DSGIRLW 355
D +R+W
Sbjct: 255 DQTVRVW 261
Score = 38.1 bits (87), Expect = 0.049
Identities = 34/143 (23%), Positives = 64/143 (44%), Gaps = 21/143 (14%)
Query: 228 PVAPDR-RISGHVGIIFSMSYLESKGLLATASEDRSVRIW--KVGD----LRVPGGRVQN 280
P P++ +SGH + + + ++ +ASED ++++W + GD L+ VQ+
Sbjct: 96 PRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQD 155
Query: 281 IGHCFGHSARVWQVKLLENYLISAGEDCVCLVWSHEG-EILQAFRGHQGRGIRAIAAHER 339
I F HS ++ L S D +W +G E ++ GH + ++A
Sbjct: 156 IS--FDHSGKL---------LASCSADMTIKLWDFQGFECIRTMHGHD-HNVSSVAIMPN 203
Query: 340 QAWVITGGDDSGIRLWHLVGRGY 362
+++ D I++W V GY
Sbjct: 204 GDHIVSASRDKTIKMWE-VQTGY 225
Score = 32.3 bits (72), Expect = 2.7
Identities = 36/167 (21%), Positives = 69/167 (41%), Gaps = 21/167 (12%)
Query: 204 TIVAGAVSNQLL-VWYPATALADNKPVAPDRRISGHVGIIFSMSYLESKGLLATASEDRS 262
T++A ++Q + VW AT K + R HV S + S ++ A+ +
Sbjct: 247 TLIASCSNDQTVRVWVVAT-----KECKAELREHEHVVECISWAPESSYSSISEATGSET 301
Query: 263 VRIWKVGDLRVPGGRVQNI-------GHCF----GHSARVWQVKLLEN--YLISAGEDCV 309
+ K G + G R + I G C GH V V +++S +D
Sbjct: 302 KKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKT 361
Query: 310 CLVWSHEGE-ILQAFRGHQGRGIRAIAAHERQAWVITGGDDSGIRLW 355
VW ++ + ++ H+ + ++ H+ +V+TG D +++W
Sbjct: 362 LRVWDYKNKRCMKTLNAHE-HFVTSLDFHKTAPYVVTGSVDQTVKVW 407
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.446
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,267,024
Number of Sequences: 37866
Number of extensions: 2631759
Number of successful extensions: 8037
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 52
Number of HSP's successfully gapped in prelim test: 136
Number of HSP's that attempted gapping in prelim test: 7265
Number of HSP's gapped (non-prelim): 785
length of query: 1151
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1038
effective length of database: 13,968,660
effective search space: 14499469080
effective search space used: 14499469080
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.