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Search of human proteins with 194239684
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194239684 single-minded homolog 2 short isoform [Homo
sapiens]
(570 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194239684 single-minded homolog 2 short isoform [Homo sapiens] 1162 0.0
gi|4827004 single-minded homolog 2 long isoform [Homo sapiens] 1070 0.0
gi|21614542 single-minded homolog 1 [Homo sapiens] 676 0.0
gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens] 301 1e-81
gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens] 294 2e-79
gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2 ... 275 8e-74
gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1 [... 275 8e-74
gi|22027482 neuronal PAS domain protein 1 [Homo sapiens] 274 2e-73
gi|40254439 endothelial PAS domain protein 1 [Homo sapiens] 244 2e-64
gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a ... 228 1e-59
gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c ... 228 1e-59
gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b ... 189 8e-48
gi|4502003 aryl hydrocarbon receptor [Homo sapiens] 127 3e-29
gi|71852582 aryl hydrocarbon receptor nuclear translocator-like ... 124 2e-28
gi|71852580 aryl hydrocarbon receptor nuclear translocator-like ... 124 2e-28
gi|42716311 aryl hydrocarbon receptor nuclear translocator-like ... 124 2e-28
gi|31745180 aryl hydrocarbon receptor nuclear translocator-like ... 115 8e-26
gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Ho... 114 2e-25
gi|194097477 neuronal PAS domain protein 4 [Homo sapiens] 106 7e-23
gi|4758010 clock [Homo sapiens] 105 1e-22
gi|30795242 aryl hydrocarbon receptor nuclear translocator isofo... 101 2e-21
gi|4502231 aryl hydrocarbon receptor nuclear translocator isofor... 101 2e-21
gi|22027471 neuronal PAS domain protein 2 [Homo sapiens] 91 2e-18
gi|115430245 arylhydrocarbon receptor repressor [Homo sapiens] 91 4e-18
gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens] 83 6e-16
gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens] 83 6e-16
gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens] 83 6e-16
gi|30795240 aryl hydrocarbon receptor nuclear translocator isofo... 69 2e-11
gi|5729858 nuclear receptor coactivator 2 [Homo sapiens] 68 2e-11
gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens] 59 1e-08
>gi|194239684 single-minded homolog 2 short isoform [Homo sapiens]
Length = 570
Score = 1162 bits (3007), Expect = 0.0
Identities = 570/570 (100%), Positives = 570/570 (100%)
Query: 1 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGL 60
MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGL
Sbjct: 1 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGL 60
Query: 61 GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT 120
GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT
Sbjct: 61 GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT 120
Query: 121 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGY 180
GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGY
Sbjct: 121 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGY 180
Query: 181 KVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDL 240
KVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDL
Sbjct: 181 KVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDL 240
Query: 241 KLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSK 300
KLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSK
Sbjct: 241 KLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSK 300
Query: 301 RGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTAL 360
RGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTAL
Sbjct: 301 RGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTAL 360
Query: 361 STSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRASPPASAAAPPE 420
STSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRASPPASAAAPPE
Sbjct: 361 STSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRASPPASAAAPPE 420
Query: 421 LQPHSESSDLLYTPSYSLPFSYHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEVARFFL 480
LQPHSESSDLLYTPSYSLPFSYHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEVARFFL
Sbjct: 421 LQPHSESSDLLYTPSYSLPFSYHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEVARFFL 480
Query: 481 STLPASGECQWHYANPLVPSSSSPAKNPPEPPANTARHSLVPSYEGGSGLLVGKVGGLRT 540
STLPASGECQWHYANPLVPSSSSPAKNPPEPPANTARHSLVPSYEGGSGLLVGKVGGLRT
Sbjct: 481 STLPASGECQWHYANPLVPSSSSPAKNPPEPPANTARHSLVPSYEGGSGLLVGKVGGLRT 540
Query: 541 AGSRSSHGGGWQMETEPSRFGQTCPLSASK 570
AGSRSSHGGGWQMETEPSRFGQTCPLSASK
Sbjct: 541 AGSRSSHGGGWQMETEPSRFGQTCPLSASK 570
>gi|4827004 single-minded homolog 2 long isoform [Homo sapiens]
Length = 667
Score = 1070 bits (2768), Expect = 0.0
Identities = 525/525 (100%), Positives = 525/525 (100%)
Query: 1 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGL 60
MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGL
Sbjct: 1 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGL 60
Query: 61 GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT 120
GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT
Sbjct: 61 GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT 120
Query: 121 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGY 180
GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGY
Sbjct: 121 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGY 180
Query: 181 KVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDL 240
KVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDL
Sbjct: 181 KVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDL 240
Query: 241 KLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSK 300
KLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSK
Sbjct: 241 KLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSK 300
Query: 301 RGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTAL 360
RGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTAL
Sbjct: 301 RGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTAL 360
Query: 361 STSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRASPPASAAAPPE 420
STSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRASPPASAAAPPE
Sbjct: 361 STSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRASPPASAAAPPE 420
Query: 421 LQPHSESSDLLYTPSYSLPFSYHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEVARFFL 480
LQPHSESSDLLYTPSYSLPFSYHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEVARFFL
Sbjct: 421 LQPHSESSDLLYTPSYSLPFSYHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEVARFFL 480
Query: 481 STLPASGECQWHYANPLVPSSSSPAKNPPEPPANTARHSLVPSYE 525
STLPASGECQWHYANPLVPSSSSPAKNPPEPPANTARHSLVPSYE
Sbjct: 481 STLPASGECQWHYANPLVPSSSSPAKNPPEPPANTARHSLVPSYE 525
>gi|21614542 single-minded homolog 1 [Homo sapiens]
Length = 766
Score = 676 bits (1743), Expect = 0.0
Identities = 353/509 (69%), Positives = 391/509 (76%), Gaps = 11/509 (2%)
Query: 1 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGL 60
MKEKSKNAA+TRREKEN EFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMR VFPEGL
Sbjct: 1 MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGL 60
Query: 61 GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT 120
G+AWG SR PLD V +ELGSHLLQTLDGF+FVVA DGKIMYISETASVHLGLSQVELT
Sbjct: 61 GEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELT 120
Query: 121 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGY 180
GNSIYEYIHP+DHDEMTAVLTAHQP H H +QEYEIERSFFLRMKCVLAKRNAGLTC GY
Sbjct: 121 GNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGY 180
Query: 181 KVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDL 240
KVIHCSGYLKIRQY LDMS +D CYQ VGLVAVG SLPPSA+TEIKL+SNMFMFRASLD+
Sbjct: 181 KVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDM 240
Query: 241 KLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSK 300
KLIFLDSRV E+TGYEPQDLIEKTLYHHVHGCD FHLR AHHLLLVKGQVTTKYYR L+K
Sbjct: 241 KLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYRFLAK 300
Query: 301 RGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTAL 360
GGWVWVQSYAT+VHNSRSSRPHCIVSVNYVLT+ EYK LQLSL+Q+S +K S+ ++
Sbjct: 301 HGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQISASKPAFSYTSSS 360
Query: 361 S-TSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRASPPASAAAP- 418
+ T + RK K + + K+K RT+PYP QYS F ++ E W SP A+P
Sbjct: 361 TPTMTDNRKGAKSRLSSSKSKSRTSPYP--QYSGFHTERSESDHDSQWGGSPLTDTASPQ 418
Query: 419 ---PELQPHSESSDLLYTPSYSLPFSYHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEV 475
P +P S+ +S S YG F LD ++ +G CE
Sbjct: 419 LLDPADRPGSQHDASCAYRQFSDRSSLCYG-FALDHSRLVEERHFHTQAC---EGGRCEA 474
Query: 476 ARFFLSTLPASGECQWHYANPLVPSSSSP 504
R+FL T A E W L + +SP
Sbjct: 475 GRYFLGTPQAGREPWWGSRAALPLTKASP 503
>gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens]
Length = 901
Score = 301 bits (771), Expect = 1e-81
Identities = 173/418 (41%), Positives = 242/418 (57%), Gaps = 54/418 (12%)
Query: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61
KEKS++AA++RR KEN EFYELAKLLPLP+AITSQLDKASIIRLT SYLKMR +G
Sbjct: 23 KEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQG-D 81
Query: 62 DAW--------------GQPSRAGP----LDGVAKELGSHLLQTLDGFVFVVASDGKIMY 103
W G R P ++ LGSH+LQ+LDGFVF + +GK +Y
Sbjct: 82 PPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLY 141
Query: 104 ISETASVHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQE---------- 153
ISET S++LGLSQVELTG+S+++Y+HP DH EM L P LL +
Sbjct: 142 ISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASSA 201
Query: 154 -----------------------YEIERSFFLRMKCVLAKRNAGLTCSGYKVIHCSGYLK 190
+ERSFF+RMK L KR + SGYKVIH +G L+
Sbjct: 202 SSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRGVHIKSSGYKVIHITGRLR 261
Query: 191 IRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVT 250
+R + S QI+GLV V +LPP I E+++ +MF+ R ++DL +I+ ++R++
Sbjct: 262 LRVSLSHGRTVPS--QIMGLVVVAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCENRIS 319
Query: 251 EVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSKRGGWVWVQSY 310
+ P D++ K YH +H DV +R++H LL KGQ TKYYR + K GG++W+QS
Sbjct: 320 DYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGYIWIQSS 379
Query: 311 ATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTALSTSQETRK 368
AT+ N++++ I+ VNY+L+ EYK+ + + Q+ + S + S S+ K
Sbjct: 380 ATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHLPEKTSESSETSDSESDSK 437
>gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens]
Length = 920
Score = 294 bits (752), Expect = 2e-79
Identities = 173/437 (39%), Positives = 242/437 (55%), Gaps = 73/437 (16%)
Query: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61
KEKS++AA++RR KEN EFYELAKLLPLP+AITSQLDKASIIRLT SYLKMR +G
Sbjct: 23 KEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQG-D 81
Query: 62 DAW---------------------------------GQPSRAGP----LDGVAKELGSHL 84
W G R P ++ LGSH+
Sbjct: 82 PPWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHLGSHI 141
Query: 85 LQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHQ 144
LQ+LDGFVF + +GK +YISET S++LGLSQVELTG+S+++Y+HP DH EM L
Sbjct: 142 LQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKL 201
Query: 145 PLHHHLLQE---------------------------------YEIERSFFLRMKCVLAKR 171
P LL + +ERSFF+RMK L KR
Sbjct: 202 PPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKR 261
Query: 172 NAGLTCSGYKVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNM 231
+ SGYKVIH +G L++R + S QI+GLV V +LPP I E+++ +M
Sbjct: 262 GVHIKSSGYKVIHITGRLRLRVSLSHGRTVPS--QIMGLVVVAHALPPPTINEVRIDCHM 319
Query: 232 FMFRASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVT 291
F+ R ++DL +I+ ++R+++ P D++ K YH +H DV +R++H LL KGQ
Sbjct: 320 FVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCV 379
Query: 292 TKYYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAK 351
TKYYR + K GG++W+QS AT+ N++++ I+ VNY+L+ EYK+ + + Q+
Sbjct: 380 TKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHLP 439
Query: 352 SQDSWRTALSTSQETRK 368
+ S + S S+ K
Sbjct: 440 EKTSESSETSDSESDSK 456
>gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2
[Homo sapiens]
Length = 735
Score = 275 bits (703), Expect = 8e-74
Identities = 152/374 (40%), Positives = 231/374 (61%), Gaps = 21/374 (5%)
Query: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61
KEKS++AA++RR KE+ FYELA LPLP ++S LDKAS++RLT SYL++R + G
Sbjct: 19 KEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDL 78
Query: 62 DAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTG 121
D D + ++ L+ LDGFV V+ DG ++YIS+ + ++GL+Q ELTG
Sbjct: 79 DIE---------DDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTG 129
Query: 122 NSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSG-- 179
+S++++ HP DH+EM +LT L +E +RSFFLRMKC L R +
Sbjct: 130 HSVFDFTHPCDHEEMREMLTHRNGLVKKG-KEQNTQRSFFLRMKCTLTSRGRTMNIKSAT 188
Query: 180 YKVIHCSGYLKIRQYMLDMSLYDSCYQ---IVGLVAVGQSLPPSAITEIKLYSNMFMFRA 236
+KV+HC+G++ + Y + + Y+ + LV + + +P + EI L S F+ R
Sbjct: 189 WKVLHCTGHIHV--YDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRH 246
Query: 237 SLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYR 296
SLD+K + D R+TE+ GYEP++L+ +++Y + H D HL HH + KGQVTT YR
Sbjct: 247 SLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYR 306
Query: 297 LLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQ----VSTAKS 352
+L+KRGG+VWV++ ATV++N+++S+P CIV VNYV++ I +L SL+Q + +S
Sbjct: 307 MLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVES 366
Query: 353 QDSWRTALSTSQET 366
D T L T E+
Sbjct: 367 SDMKMTQLFTKVES 380
>gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1
[Homo sapiens]
Length = 826
Score = 275 bits (703), Expect = 8e-74
Identities = 152/374 (40%), Positives = 231/374 (61%), Gaps = 21/374 (5%)
Query: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61
KEKS++AA++RR KE+ FYELA LPLP ++S LDKAS++RLT SYL++R + G
Sbjct: 19 KEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDL 78
Query: 62 DAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTG 121
D D + ++ L+ LDGFV V+ DG ++YIS+ + ++GL+Q ELTG
Sbjct: 79 DIE---------DDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTG 129
Query: 122 NSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSG-- 179
+S++++ HP DH+EM +LT L +E +RSFFLRMKC L R +
Sbjct: 130 HSVFDFTHPCDHEEMREMLTHRNGLVKKG-KEQNTQRSFFLRMKCTLTSRGRTMNIKSAT 188
Query: 180 YKVIHCSGYLKIRQYMLDMSLYDSCYQ---IVGLVAVGQSLPPSAITEIKLYSNMFMFRA 236
+KV+HC+G++ + Y + + Y+ + LV + + +P + EI L S F+ R
Sbjct: 189 WKVLHCTGHIHV--YDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRH 246
Query: 237 SLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYR 296
SLD+K + D R+TE+ GYEP++L+ +++Y + H D HL HH + KGQVTT YR
Sbjct: 247 SLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYR 306
Query: 297 LLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQ----VSTAKS 352
+L+KRGG+VWV++ ATV++N+++S+P CIV VNYV++ I +L SL+Q + +S
Sbjct: 307 MLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVES 366
Query: 353 QDSWRTALSTSQET 366
D T L T E+
Sbjct: 367 SDMKMTQLFTKVES 380
>gi|22027482 neuronal PAS domain protein 1 [Homo sapiens]
Length = 590
Score = 274 bits (700), Expect = 2e-73
Identities = 163/389 (41%), Positives = 225/389 (57%), Gaps = 58/389 (14%)
Query: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61
KEKS+NAA++RR KEN EF+ELAKLLPLP AI+SQLDKASI+RL+ +YL++R G
Sbjct: 47 KEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALG-A 105
Query: 62 DAWG----------QPSRAGPLDGVAK----ELGSHLLQTLDGFVFVVASDGKIMYISET 107
WG P R GP V++ LG H+LQ+LDGFVF + +GK +YISET
Sbjct: 106 PPWGLRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISET 165
Query: 108 ASVHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHQPL---------------HHHLLQ 152
S++LGLSQVE+TG+S+++YIHP DH E+ L P L
Sbjct: 166 VSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLAD 225
Query: 153 EYEI--------------ERSFFLRMKCVLAKRNAGLTCSGYKVIHCSGYLKIRQYMLDM 198
EI ERSFF+RMK L KR + SGYKVIH +G L+
Sbjct: 226 TPEIEASLTKVPPSSLVQERSFFVRMKSTLTKRGLHVKASGYKVIHVTGRLRA------- 278
Query: 199 SLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEVTGYEPQ 258
+GLVA+G +LPP+ + E+ L+ +M +FR SL L ++ +SRV++ P
Sbjct: 279 -------HALGLVALGHTLPPAPLAELPLHGHMIVFRLSLGLTILACESRVSDHMDLGPS 331
Query: 259 DLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSR 318
+L+ ++ Y VHG D +R +H LL KGQV T YYR L + GG+VW+QS ATV + +
Sbjct: 332 ELVGRSCYQFVHGQDATRIRQSHVDLLDKGQVMTGYYRWLQRAGGFVWLQSVATVAGSGK 391
Query: 319 SSRPHCIVSVNYVLTEIEYKELQLSLEQV 347
S H ++ V++VL++ E + L Q+
Sbjct: 392 SPGEHHVLWVSHVLSQAEGGQTPLDAFQL 420
>gi|40254439 endothelial PAS domain protein 1 [Homo sapiens]
Length = 870
Score = 244 bits (623), Expect = 2e-64
Identities = 149/461 (32%), Positives = 244/461 (52%), Gaps = 39/461 (8%)
Query: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61
KEKS++AA+ RR KE FYELA LPLP +++S LDKASI+RL S+L+ +
Sbjct: 16 KEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSVCS 75
Query: 62 DAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTG 121
+ + +D + L+ L+GF+ VV DG ++++SE S +GL+QVELTG
Sbjct: 76 ENESEAEADQQMDNL-------YLKALEGFIAVVTQDGDMIFLSENISKFMGLTQVELTG 128
Query: 122 NSIYEYIHPSDHDEMTAVLTAHQPLHH-HLLQEYEIERSFFLRMKCVLAKRN--AGLTCS 178
+SI+++ HP DH+E+ L+ ++ ER FF+RMKC + R L +
Sbjct: 129 HSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRGRTVNLKSA 188
Query: 179 GYKVIHCSGYLKIRQYMLDMSLYDSC--------YQ---IVGLVAVGQSLPPSAITEIKL 227
+KV+HC+G +K+ Y++C Y+ + L+ + + + + +I L
Sbjct: 189 TWKVLHCTGQVKV---------YNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPL 239
Query: 228 YSNMFMFRASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVK 287
S F+ R S+D+K + D R+TE+ GY P++L+ ++ Y H D ++ +H L K
Sbjct: 240 DSKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTK 299
Query: 288 GQVTTKYYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQV 347
GQV + YR+L+K GG+VW+++ TV++N R+ +P CI+ VNYVL+EIE ++ S++Q
Sbjct: 300 GQVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQT 359
Query: 348 STAKSQDSWRTALSTSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNW 407
+ + V K+ + TKL+ P Q + D + GN
Sbjct: 360 ESLFKPHLMAMNSIFDSSGKGAVSEKSNFLFTKLKEEPEELAQLAPTPGDAIISLDFGNQ 419
Query: 408 ---RASPPASAAAPP------ELQPHSESSDLLYTPSYSLP 439
+S A PP EL+ HS S+ P++++P
Sbjct: 420 NFEESSAYGKAILPPSQPWATELRSHSTQSEAGSLPAFTVP 460
>gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a
[Homo sapiens]
Length = 667
Score = 228 bits (580), Expect = 1e-59
Identities = 136/351 (38%), Positives = 199/351 (56%), Gaps = 17/351 (4%)
Query: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61
KEKS++AA++RR +E Y+LA LP +++ LDKASI+RLT SYL+M + G
Sbjct: 14 KEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAG-- 71
Query: 62 DAWGQPSRAG-PLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT 120
W Q G PLD L+ L+GFV V+ ++G + Y+SE S HLGLSQ+EL
Sbjct: 72 -EWNQVGAGGEPLDAC-------YLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELI 123
Query: 121 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNA--GLTCS 178
G+SI+++IHP D +E+ LT Q L + E ER F LRMK L R L +
Sbjct: 124 GHSIFDFIHPCDQEELQDALTPQQTLSRRKV-EAPTERCFSLRMKSTLTSRGRTLNLKAA 182
Query: 179 GYKVIHCSGYLKIRQYMLDMSLY---DSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFR 235
+KV++CSG+++ + S DS + LV + +++P E L F+ R
Sbjct: 183 TWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSR 242
Query: 236 ASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYY 295
SLD+K + D R+ EV GY P DLI + Y ++H D + + H LL KGQ T Y
Sbjct: 243 HSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQY 302
Query: 296 RLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQ 346
R L++ GG++W Q+ ATVV R + IV V+++++++E + LSLEQ
Sbjct: 303 RFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQ 353
>gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c
[Homo sapiens]
Length = 669
Score = 228 bits (580), Expect = 1e-59
Identities = 136/351 (38%), Positives = 199/351 (56%), Gaps = 17/351 (4%)
Query: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61
KEKS++AA++RR +E Y+LA LP +++ LDKASI+RLT SYL+M + G
Sbjct: 16 KEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAG-- 73
Query: 62 DAWGQPSRAG-PLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT 120
W Q G PLD L+ L+GFV V+ ++G + Y+SE S HLGLSQ+EL
Sbjct: 74 -EWNQVGAGGEPLDAC-------YLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELI 125
Query: 121 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNA--GLTCS 178
G+SI+++IHP D +E+ LT Q L + E ER F LRMK L R L +
Sbjct: 126 GHSIFDFIHPCDQEELQDALTPQQTLSRRKV-EAPTERCFSLRMKSTLTSRGRTLNLKAA 184
Query: 179 GYKVIHCSGYLKIRQYMLDMSLY---DSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFR 235
+KV++CSG+++ + S DS + LV + +++P E L F+ R
Sbjct: 185 TWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSR 244
Query: 236 ASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYY 295
SLD+K + D R+ EV GY P DLI + Y ++H D + + H LL KGQ T Y
Sbjct: 245 HSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQY 304
Query: 296 RLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQ 346
R L++ GG++W Q+ ATVV R + IV V+++++++E + LSLEQ
Sbjct: 305 RFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQ 355
>gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b
[Homo sapiens]
Length = 613
Score = 189 bits (479), Expect = 8e-48
Identities = 116/310 (37%), Positives = 170/310 (54%), Gaps = 17/310 (5%)
Query: 43 IRLTTSYLKMRAVFPEGLGDAWGQPSRAG-PLDGVAKELGSHLLQTLDGFVFVVASDGKI 101
+RLT SYL+M + G W Q G PLD L+ L+GFV V+ ++G +
Sbjct: 1 MRLTISYLRMHRLCAAG---EWNQVGAGGEPLDAC-------YLKALEGFVMVLTAEGDM 50
Query: 102 MYISETASVHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFF 161
Y+SE S HLGLSQ+EL G+SI+++IHP D +E+ LT Q L + E ER F
Sbjct: 51 AYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKV-EAPTERCFS 109
Query: 162 LRMKCVLAKRNA--GLTCSGYKVIHCSGYLKIRQYMLDMSLY---DSCYQIVGLVAVGQS 216
LRMK L R L + +KV++CSG+++ + S DS + LV + ++
Sbjct: 110 LRMKSTLTSRGRTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEA 169
Query: 217 LPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFH 276
+P E L F+ R SLD+K + D R+ EV GY P DLI + Y ++H D
Sbjct: 170 IPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDA 229
Query: 277 LRYAHHLLLVKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIE 336
+ + H LL KGQ T YR L++ GG++W Q+ ATVV R + IV V+++++++E
Sbjct: 230 VSKSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVE 289
Query: 337 YKELQLSLEQ 346
+ LSLEQ
Sbjct: 290 ETGVVLSLEQ 299
>gi|4502003 aryl hydrocarbon receptor [Homo sapiens]
Length = 848
Score = 127 bits (319), Expect = 3e-29
Identities = 101/368 (27%), Positives = 163/368 (44%), Gaps = 43/368 (11%)
Query: 7 NAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLGDA--- 63
N +K R++ N E LA LLP P + ++LDK S++RL+ SYL+ ++ F L +
Sbjct: 34 NPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSSPTE 93
Query: 64 --WGQPS--RAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVEL 119
GQ + A +G+ + G LLQ L+GFV VV +D + Y S T +LG Q ++
Sbjct: 94 RNGGQDNCRAANFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASSTIQDYLGFQQSDV 153
Query: 120 TGNSIYEYIHPSDHDE--------------------------MTAVLTAHQPLHHHLLQE 153
S+YE IH D E + + + P
Sbjct: 154 IHQSVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLPQTVVCYNPDQIPPENS 213
Query: 154 YEIERSFFLRMKCVLAKRNAGLTCSGYKVIHCSGYLKIRQYMLDMSLYDSCY-QIVGLVA 212
+ER F R++C+L SG+ ++ G LK S + L A
Sbjct: 214 PLMERCFICRLRCLLD------NSSGFLAMNFQGKLKYLHGQKKKGKDGSILPPQLALFA 267
Query: 213 VGQSLPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEVTGYEPQDLIEK-TLYHHVHG 271
+ L P +I EI+ + +F + LD I D++ V GY +L + + Y +H
Sbjct: 268 IATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTEAELCTRGSGYQFIHA 327
Query: 272 CDVFHLRYAHHLLLVKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYV 331
D+ + +H ++ G+ +RLL+K W WVQS A +++ ++ RP I+
Sbjct: 328 ADMLYCAESHIRMIKTGESGMIVFRLLTKNNRWTWVQSNARLLY--KNGRPDYIIVTQRP 385
Query: 332 LTEIEYKE 339
LT+ E E
Sbjct: 386 LTDEEGTE 393
>gi|71852582 aryl hydrocarbon receptor nuclear translocator-like
isoform b [Homo sapiens]
Length = 582
Score = 124 bits (311), Expect = 2e-28
Identities = 105/373 (28%), Positives = 174/373 (46%), Gaps = 48/373 (12%)
Query: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61
+E K RR+K N ELA L+P +A++ +LDK +++R+ ++K
Sbjct: 31 REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYT 90
Query: 62 DAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASD-GKIMYISETASVHLGLSQVELT 120
+A +P+ EL +L+ DGF+FVV D GKI+++SE+ L SQ +L
Sbjct: 91 EANYKPTFLSD-----DELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLI 145
Query: 121 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEI-------------------ERSFF 161
G S+++Y+HP D ++ L++ L + + RSFF
Sbjct: 146 GQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFF 205
Query: 162 LRMKC-----VLAKRNAGLTCSGYK------VIHCSGYLKI---RQYMLDMSLY---DSC 204
RMKC + ++ TCS K IH +GYLK + LD + C
Sbjct: 206 CRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGC 265
Query: 205 YQIVGLVAVGQS----LPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEVTGYEPQDL 260
+ LVA+G+ +P EI++ S ++ R ++D K +F+D R T + Y PQ+L
Sbjct: 266 -NLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQEL 324
Query: 261 IEKTLYHHVHGCDVFHLRYAH-HLLLVKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSRS 319
+ + Y + H D+ HL H +L + ++TT Y+ K G ++ ++S N +
Sbjct: 325 LGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWT 384
Query: 320 SRPHCIVSVNYVL 332
IVS N V+
Sbjct: 385 KEVEYIVSTNTVV 397
>gi|71852580 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 124 bits (311), Expect = 2e-28
Identities = 105/373 (28%), Positives = 174/373 (46%), Gaps = 48/373 (12%)
Query: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61
+E K RR+K N ELA L+P +A++ +LDK +++R+ ++K
Sbjct: 74 REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYT 133
Query: 62 DAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASD-GKIMYISETASVHLGLSQVELT 120
+A +P+ EL +L+ DGF+FVV D GKI+++SE+ L SQ +L
Sbjct: 134 EANYKPTFLSD-----DELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLI 188
Query: 121 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEI-------------------ERSFF 161
G S+++Y+HP D ++ L++ L + + RSFF
Sbjct: 189 GQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFF 248
Query: 162 LRMKC-----VLAKRNAGLTCSGYK------VIHCSGYLKI---RQYMLDMSLY---DSC 204
RMKC + ++ TCS K IH +GYLK + LD + C
Sbjct: 249 CRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGC 308
Query: 205 YQIVGLVAVGQS----LPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEVTGYEPQDL 260
+ LVA+G+ +P EI++ S ++ R ++D K +F+D R T + Y PQ+L
Sbjct: 309 -NLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQEL 367
Query: 261 IEKTLYHHVHGCDVFHLRYAH-HLLLVKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSRS 319
+ + Y + H D+ HL H +L + ++TT Y+ K G ++ ++S N +
Sbjct: 368 LGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWT 427
Query: 320 SRPHCIVSVNYVL 332
IVS N V+
Sbjct: 428 KEVEYIVSTNTVV 440
>gi|42716311 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 124 bits (311), Expect = 2e-28
Identities = 105/373 (28%), Positives = 174/373 (46%), Gaps = 48/373 (12%)
Query: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61
+E K RR+K N ELA L+P +A++ +LDK +++R+ ++K
Sbjct: 74 REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYT 133
Query: 62 DAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASD-GKIMYISETASVHLGLSQVELT 120
+A +P+ EL +L+ DGF+FVV D GKI+++SE+ L SQ +L
Sbjct: 134 EANYKPTFLSD-----DELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLI 188
Query: 121 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEI-------------------ERSFF 161
G S+++Y+HP D ++ L++ L + + RSFF
Sbjct: 189 GQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFF 248
Query: 162 LRMKC-----VLAKRNAGLTCSGYK------VIHCSGYLKI---RQYMLDMSLY---DSC 204
RMKC + ++ TCS K IH +GYLK + LD + C
Sbjct: 249 CRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGC 308
Query: 205 YQIVGLVAVGQS----LPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEVTGYEPQDL 260
+ LVA+G+ +P EI++ S ++ R ++D K +F+D R T + Y PQ+L
Sbjct: 309 -NLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQEL 367
Query: 261 IEKTLYHHVHGCDVFHLRYAH-HLLLVKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSRS 319
+ + Y + H D+ HL H +L + ++TT Y+ K G ++ ++S N +
Sbjct: 368 LGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWT 427
Query: 320 SRPHCIVSVNYVL 332
IVS N V+
Sbjct: 428 KEVEYIVSTNTVV 440
>gi|31745180 aryl hydrocarbon receptor nuclear translocator-like 2
[Homo sapiens]
Length = 636
Score = 115 bits (289), Expect = 8e-26
Identities = 104/373 (27%), Positives = 174/373 (46%), Gaps = 57/373 (15%)
Query: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61
+E K RR+K N EL+ ++P + + +LDK +++R+ +L+ +GL
Sbjct: 109 REAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSL----KGLT 164
Query: 62 DAW-GQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASD-GKIMYISETASVHLGLSQVEL 119
+++ G R L EL +L+T +GF+FVV + GKI+++S++ S L Q L
Sbjct: 165 NSYVGSNYRPSFLQD--NELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASL 222
Query: 120 TGNSIYEYIHPSDHDEMTAVLTA------------------HQPLHHHLLQEYE-IERSF 160
TG S+++++HP D ++ L++ H LH + Y RSF
Sbjct: 223 TGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRSF 282
Query: 161 FLRMKC--VLAKRNAGLTCSGYK-------VIHCSGYLKI-----------RQYMLDMSL 200
F R+K + K G + K IHC+GYL+ R D S
Sbjct: 283 FCRIKSCKISVKEEHGCLPNSKKKEHRKFYTIHCTGYLRSWPPNIVGMEEERNSKKDNSN 342
Query: 201 YDSCYQIVGLVAVGQSLP---PSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEVTGYEP 257
+ +C LVA+G+ P P EI + F+ R +++ K +++D R T + GY P
Sbjct: 343 F-TC-----LVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLP 396
Query: 258 QDLIEKTLYHHVHGCDVFHLRYAHHLLL-VKGQVTTKYYRLLSKRGGWVWVQSYATVVHN 316
Q+L+ + Y + H D +L H +L K ++ T Y+ +K G +V ++S N
Sbjct: 397 QELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFTN 456
Query: 317 SRSSRPHCIVSVN 329
+ IVSVN
Sbjct: 457 PWTKELEYIVSVN 469
>gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Homo
sapiens]
Length = 717
Score = 114 bits (285), Expect = 2e-25
Identities = 103/403 (25%), Positives = 183/403 (45%), Gaps = 57/403 (14%)
Query: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLK-MRAVFPEGL 60
+E + RR K EL+ ++P SA+ + DK +I+R+ S++K MR +
Sbjct: 65 RENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMKSMRGTGNKST 124
Query: 61 GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASD-GKIMYISETASVHLGLSQVEL 119
A+ +PS +EL +L+ DGF+FVVA++ G+++Y+S++ + L Q E
Sbjct: 125 DGAY-KPSFL-----TEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNQPQSEW 178
Query: 120 TGNSIYEYIHPSDHDEMTAVL-TAHQPLHHHLL-----------QEYEIE------RSFF 161
G+++YE +HP D +++ L T+ + +L Q+ + RSF
Sbjct: 179 FGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFI 238
Query: 162 LRMKCVLA-----------------KRNAGLTCSG---YKVIHCSGYLK--------IRQ 193
RM+C A + G G Y V+HC+GY+K I +
Sbjct: 239 CRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKAWPPAGMTIPE 298
Query: 194 YMLDMSLYDS-CYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEV 252
D+ C +G + V S + + + + F+ R + D + F+D R V
Sbjct: 299 EDADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVPTE-FLSRHNSDGIITFVDPRCISV 357
Query: 253 TGYEPQDLIEKTLYHHVHGCDVFHLRYA-HHLLLVKGQVTTKYYRLLSKRGGWVWVQSYA 311
GY+PQDL+ K + H D HLR + ++ +KGQV + YR +K W+ +++ +
Sbjct: 358 IGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNREWMLIRTSS 417
Query: 312 TVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQD 354
N S I+ N + +++ ++ +L + Q S D
Sbjct: 418 FTFQNPYSDEIEYIICTNTNVKQLQQQQAELEVHQRDGLSSYD 460
>gi|194097477 neuronal PAS domain protein 4 [Homo sapiens]
Length = 802
Score = 106 bits (264), Expect = 7e-23
Identities = 143/566 (25%), Positives = 229/566 (40%), Gaps = 77/566 (13%)
Query: 1 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGL 60
M +K A+K RR++ N E L +LLPL A +L I+ L Y + F
Sbjct: 1 MYRSTKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFF---- 56
Query: 61 GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT 120
A G P AGP ++ + ++ L GF+ V ++GK++Y+SE+ S HLG S V+L
Sbjct: 57 --AGGTPL-AGPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLV 113
Query: 121 --GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCS 178
G+SIY+ I P+DH LT Q L L + +R F R + R +
Sbjct: 114 AQGDSIYDIIDPADH------LTVRQQL--TLPSALDTDRLFRCRFNTSKSLRRQS---A 162
Query: 179 GYKVIHCSGYLKIR---QYMLDMSLYDS-CYQIVGLVAVGQSLPPSAITEIKLYSNMFMF 234
G K++ G Y ++ + C + G P + L+ MF
Sbjct: 163 GNKLVLIRGRFHAHPPGAYWAGNPVFTAFCAPLEPRPRPGPGPGPGPAS---LFLAMFQS 219
Query: 235 RASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVK-GQVTTK 293
R + DL L+ + V G+E +L+ K+ Y +H D+ H H+ LL + G + +
Sbjct: 220 RHAKDLALLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAE 279
Query: 294 -YYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKS 352
RL +K GGW W+ ++++ P I + NY ++++E L+ +Q+++ +
Sbjct: 280 MVVRLQAKTGGWAWIY---CLLYSEGPEGP--ITANNYPISDMEAWSLR---QQLNSEDT 331
Query: 353 QDSWRTALST----------SQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECG 402
Q ++ T SQE P T R+ +P S E
Sbjct: 332 QAAYVLGTPTMLPSFPENILSQEECSSTNPLFTAALGAPRSTSFPSAPELSVVSASEELP 391
Query: 403 QLGNWRASPPASAAAPPELQPHSE-SSDLLYTPSY--------SLPFSYH---YGHFPLD 450
+ + + PE +E S DL+ TP Y + FS H H P
Sbjct: 392 RPSKELDFSYLTFPSGPEPSLQAELSKDLVCTPPYTPHQPGGCAFLFSLHEPFQTHLPTP 451
Query: 451 SH-----------VFSSKKPMLPAKFGQPQGSPCEVARFFLSTLPASGE---CQWHYANP 496
S FS + A F P SP + S + C + +
Sbjct: 452 SSTLQEQLTPSTATFSDQLTPSSATFPDPLTSPLQGQLTETSVRSYEDQLTPCTSTFPDQ 511
Query: 497 LVPSSSSPAKNPPEPPANTARHSLVP 522
L+PS+++ PEP + A L P
Sbjct: 512 LLPSTAT----FPEPLGSPAHEQLTP 533
>gi|4758010 clock [Homo sapiens]
Length = 846
Score = 105 bits (261), Expect = 1e-22
Identities = 93/381 (24%), Positives = 171/381 (44%), Gaps = 32/381 (8%)
Query: 2 KEKSKNAAKTRREKENGEFY-----ELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVF 56
K+K+K ++ + EK+ + + EL +LP ++DK+++++ + +L+
Sbjct: 31 KDKAKRVSRNKSEKKRRDQFNVLIKELGSMLP---GNARKMDKSTVLQKSIDFLRKHKEI 87
Query: 57 PEGLGDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQ 116
DA P +E +L+ LDGF + +DG I+Y+SE+ + L
Sbjct: 88 T-AQSDASEIRQDWKPTFLSNEEFTQLMLEALDGFFLAIMTDGSIIYVSESVTSLLEHLP 146
Query: 117 VELTGNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAG-L 175
+L SI+ +I +H E+ +L+ H L EY ++ L C + +
Sbjct: 147 SDLVDQSIFNFIPEGEHSEVYKILSTHLLESDSLTPEY-LKSKNQLEFCCHMLRGTIDPK 205
Query: 176 TCSGYKVIHCSGYLKIRQYM-----------LDMSLYDSCYQIVGLVAVGQSLPPSAITE 224
S Y+ + G K + + + S V VA + P I E
Sbjct: 206 EPSTYEYVKFIGNFKSLNSVSSSAHNGFEGTIQRTHRPSYEDRVCFVATVRLATPQFIKE 265
Query: 225 ---IKLYSNMFMFRASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAH 281
++ + F R SL+ K +FLD R + GY P +++ + Y + H D+ +L H
Sbjct: 266 MCTVEEPNEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVDDLENLAKCH 325
Query: 282 HLLLVKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKE-- 339
L+ G+ + YYR L+K W+W+Q++ + ++ +SRP IV + V++ E +
Sbjct: 326 EHLMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYHQWNSRPEFIVCTHTVVSYAEVRAER 385
Query: 340 -----LQLSLEQVSTAKSQDS 355
++ SL + + KSQDS
Sbjct: 386 RRELGIEESLPETAADKSQDS 406
>gi|30795242 aryl hydrocarbon receptor nuclear translocator isoform
3 [Homo sapiens]
Length = 774
Score = 101 bits (251), Expect = 2e-21
Identities = 143/622 (22%), Positives = 245/622 (39%), Gaps = 99/622 (15%)
Query: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61
+E + RR K EL+ ++P SA+ + DK +I+R+ S++K
Sbjct: 76 RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTST 135
Query: 62 DAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASD-GKIMYISETASVHLGLSQVELT 120
D +PS +EL +L+ DGF+F+V+ + G+++Y+S++ + L Q E
Sbjct: 136 DGSYKPSFL-----TDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWF 190
Query: 121 GNSIYEYIHPSDHDEMTAVL-TAHQPLHHHLL-----------QEYEI------ERSFFL 162
G+++Y+ +HP D D++ L T+ L +L Q+ + RSF
Sbjct: 191 GSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFIC 250
Query: 163 RMKCVLA-----------------KRNAGLTCSG---YKVIHCSGYLKIRQYMLDMSLYD 202
RM+C + + G G + V+HC+GY+K +SL D
Sbjct: 251 RMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWP-PAGVSLPD 309
Query: 203 S----------CYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEV 252
C +G + V S + ++ + F+ R +++ F+D R
Sbjct: 310 DDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNV-CQPTEFISRHNIEGIFTFVDHRCVAT 368
Query: 253 TGYEPQDLIEKTLYHHVHGCDVFHLRYA-HHLLLVKGQVTTKYYRLLSKRGGWVWVQSYA 311
GY+PQ+L+ K + H D LR + ++ +KGQV + +R SK W+W+++ +
Sbjct: 369 VGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSS 428
Query: 312 TVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTALSTSQETRKLVK 371
N S EIEY + + S R LS + + +L
Sbjct: 429 FTFQNPYSD-------------EIEY----IICTNTNVKNSSQEPRPTLSNTIQRPQLGP 471
Query: 372 PKNTKMKTKLRTNPYPPQQYSSFQMDKLE----CGQLGNWRASPPASAAAPPELQPHSES 427
N ++ P QQ ++D + + + P + P +P E
Sbjct: 472 TANLPLEMG-SGQLAPRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSKP-LEK 529
Query: 428 SDLLYTPSYSLPFS--YHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEVARFFLSTLPA 485
SD L+ FS YH + + SS P F Q P + PA
Sbjct: 530 SDGLFAQDRDPRFSEIYHNINADQSKGISSSTVPATQQLFSQGNTFP-------PTPRPA 582
Query: 486 SGECQWHYANPLVPSSSSPAKNPPEPPANTARHS-----LVPSY--EGGSGLLVGKVGGL 538
A P+ + P+ + + A +RHS P++ SG +V
Sbjct: 583 ENFRNSGLAPPV--TIVQPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQ 640
Query: 539 RTAGSRSSHGGGWQMETEPSRF 560
TA +R+S G +T PS F
Sbjct: 641 ATAKTRTSQFGVGSFQT-PSSF 661
>gi|4502231 aryl hydrocarbon receptor nuclear translocator isoform 1
[Homo sapiens]
Length = 789
Score = 101 bits (251), Expect = 2e-21
Identities = 143/622 (22%), Positives = 245/622 (39%), Gaps = 99/622 (15%)
Query: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61
+E + RR K EL+ ++P SA+ + DK +I+R+ S++K
Sbjct: 91 RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTST 150
Query: 62 DAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASD-GKIMYISETASVHLGLSQVELT 120
D +PS +EL +L+ DGF+F+V+ + G+++Y+S++ + L Q E
Sbjct: 151 DGSYKPSFL-----TDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWF 205
Query: 121 GNSIYEYIHPSDHDEMTAVL-TAHQPLHHHLL-----------QEYEI------ERSFFL 162
G+++Y+ +HP D D++ L T+ L +L Q+ + RSF
Sbjct: 206 GSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFIC 265
Query: 163 RMKCVLA-----------------KRNAGLTCSG---YKVIHCSGYLKIRQYMLDMSLYD 202
RM+C + + G G + V+HC+GY+K +SL D
Sbjct: 266 RMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWP-PAGVSLPD 324
Query: 203 S----------CYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEV 252
C +G + V S + ++ + F+ R +++ F+D R
Sbjct: 325 DDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNV-CQPTEFISRHNIEGIFTFVDHRCVAT 383
Query: 253 TGYEPQDLIEKTLYHHVHGCDVFHLRYA-HHLLLVKGQVTTKYYRLLSKRGGWVWVQSYA 311
GY+PQ+L+ K + H D LR + ++ +KGQV + +R SK W+W+++ +
Sbjct: 384 VGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSS 443
Query: 312 TVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTALSTSQETRKLVK 371
N S EIEY + + S R LS + + +L
Sbjct: 444 FTFQNPYSD-------------EIEY----IICTNTNVKNSSQEPRPTLSNTIQRPQLGP 486
Query: 372 PKNTKMKTKLRTNPYPPQQYSSFQMDKLE----CGQLGNWRASPPASAAAPPELQPHSES 427
N ++ P QQ ++D + + + P + P +P E
Sbjct: 487 TANLPLEMG-SGQLAPRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSKP-LEK 544
Query: 428 SDLLYTPSYSLPFS--YHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEVARFFLSTLPA 485
SD L+ FS YH + + SS P F Q P + PA
Sbjct: 545 SDGLFAQDRDPRFSEIYHNINADQSKGISSSTVPATQQLFSQGNTFP-------PTPRPA 597
Query: 486 SGECQWHYANPLVPSSSSPAKNPPEPPANTARHS-----LVPSY--EGGSGLLVGKVGGL 538
A P+ + P+ + + A +RHS P++ SG +V
Sbjct: 598 ENFRNSGLAPPV--TIVQPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQ 655
Query: 539 RTAGSRSSHGGGWQMETEPSRF 560
TA +R+S G +T PS F
Sbjct: 656 ATAKTRTSQFGVGSFQT-PSSF 676
>gi|22027471 neuronal PAS domain protein 2 [Homo sapiens]
Length = 824
Score = 91.3 bits (225), Expect = 2e-18
Identities = 100/459 (21%), Positives = 202/459 (44%), Gaps = 58/459 (12%)
Query: 2 KEKSKNAAKTRREKENGEFY-----ELAKLLPLPSAITSQLDKASIIRLTTSYL-KMRAV 55
K+++K A++ + EK+ + + EL+ +LP T ++DK +++ +L K V
Sbjct: 6 KDRAKRASRNKSEKKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGFLQKHNEV 62
Query: 56 FPE----GLGDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVH 111
+ + W +PS +E +L+ LDGF+ V +DG I+Y+S++ +
Sbjct: 63 SAQTEICDIQQDW-KPSFLSN-----EEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPL 116
Query: 112 LGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKR 171
LG ++ ++ ++ +H E+ +L++H + EY ++ L C L +
Sbjct: 117 LGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEY-LKSDSDLEFYCHLLRG 175
Query: 172 NAG-LTCSGYKVIHCSGYLKIRQYM-------LDMSLYDSCYQIVG----LVAVGQSLPP 219
+ Y+ I G + + D +L C +G +A + P
Sbjct: 176 SLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLATP 235
Query: 220 SAITEIKLYSNM---FMFRASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFH 276
+ E+ + F R SL+ K +FLD R + GY P +++ + Y + H D+
Sbjct: 236 QFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLEL 295
Query: 277 LRYAHHLLLVKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIE 336
L H L+ G+ + YR L+K W+W+Q++ + ++ +S+P IV + V +
Sbjct: 296 LARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSV---VS 352
Query: 337 YKELQLSLEQVSTAKSQDSWRTALSTSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQM 396
Y ++++ Q + S AL +S +K K + ++ P+Q+
Sbjct: 353 YADVRVERRQELALEDPPS--EALHSS-----ALKDKGSSLE---------PRQH----F 392
Query: 397 DKLECGQLGNWRASPPASAAAPPELQPHSESSDLLYTPS 435
+ L+ G G + P++++ H+ S+ TP+
Sbjct: 393 NTLDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPT 431
>gi|115430245 arylhydrocarbon receptor repressor [Homo sapiens]
Length = 719
Score = 90.5 bits (223), Expect = 4e-18
Identities = 54/140 (38%), Positives = 79/140 (56%), Gaps = 8/140 (5%)
Query: 3 EKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLGD 62
EKS N +K R++ N E LA LLP P I S+LDK S++RL+ SYL++++ F
Sbjct: 32 EKS-NPSKRHRDRLNAELDHLASLLPFPPDIISKLDKLSVLRLSVSYLRVKSFFQVVQEQ 90
Query: 63 AWGQPSRAG-------PLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLS 115
+ QP+ PL G A G LL++L+GF VV+++G I Y S T +LG
Sbjct: 91 SSRQPAAGAPSPGDSCPLAGSAVLEGRLLLESLNGFALVVSAEGTIFYASATIVDYLGFH 150
Query: 116 QVELTGNSIYEYIHPSDHDE 135
Q ++ +IY+YIH D +
Sbjct: 151 QTDVMHQNIYDYIHVDDRQD 170
>gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens]
Length = 1399
Score = 83.2 bits (204), Expect = 6e-16
Identities = 82/319 (25%), Positives = 142/319 (44%), Gaps = 32/319 (10%)
Query: 5 SKNAAKTRREKENGEFYELAKLLPLP----SAITSQLDKASIIRLTTSYLKMRAVFPEGL 60
+ + K RRE+EN ELA+LL +++ + DK I++ T +++ +
Sbjct: 28 ASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEK 87
Query: 61 G---DAWGQPSRAGPLDGVAKE--LGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLS 115
D + + GV ++ LG LL+ LDGF FVV +G+I+++SE + +LG +
Sbjct: 88 STTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYN 147
Query: 116 QVELTGNSIYEYIHPSDHDEMTAVLTAHQPLHH-HLLQEYEIERSFFLRMKCVLAKRNAG 174
Q EL S+Y +H DH E L ++ QE S + ++ +
Sbjct: 148 QEELMNTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPDEP 207
Query: 175 LT-----CSGYKVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLP-PSAITEIKLY 228
T C Y+V+ C + + D + SC L+ + + LP P AIT ++
Sbjct: 208 GTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQSC-----LICIARRLPRPPAITGVE-- 260
Query: 229 SNMFMFRASLDLKLIFLDS---RVTEVTGYEPQDLIEKTLY--HHVHGCDVFHLRYAHHL 283
FM + K+I +D+ R TG+E DL+ K +Y G + + R
Sbjct: 261 --SFMTKQDTTGKIISIDTSSLRAAGRTGWE--DLVRKCIYAFFQPQGREPSYARQLFQE 316
Query: 284 LLVKGQVTTKYYRLLSKRG 302
++ +G ++ YR + G
Sbjct: 317 VMTRGTASSPSYRFILNDG 335
>gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens]
Length = 1440
Score = 83.2 bits (204), Expect = 6e-16
Identities = 82/319 (25%), Positives = 142/319 (44%), Gaps = 32/319 (10%)
Query: 5 SKNAAKTRREKENGEFYELAKLLPLP----SAITSQLDKASIIRLTTSYLKMRAVFPEGL 60
+ + K RRE+EN ELA+LL +++ + DK I++ T +++ +
Sbjct: 28 ASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEK 87
Query: 61 G---DAWGQPSRAGPLDGVAKE--LGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLS 115
D + + GV ++ LG LL+ LDGF FVV +G+I+++SE + +LG +
Sbjct: 88 STTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYN 147
Query: 116 QVELTGNSIYEYIHPSDHDEMTAVLTAHQPLHH-HLLQEYEIERSFFLRMKCVLAKRNAG 174
Q EL S+Y +H DH E L ++ QE S + ++ +
Sbjct: 148 QEELMNTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPDEP 207
Query: 175 LT-----CSGYKVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLP-PSAITEIKLY 228
T C Y+V+ C + + D + SC L+ + + LP P AIT ++
Sbjct: 208 GTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQSC-----LICIARRLPRPPAITGVE-- 260
Query: 229 SNMFMFRASLDLKLIFLDS---RVTEVTGYEPQDLIEKTLY--HHVHGCDVFHLRYAHHL 283
FM + K+I +D+ R TG+E DL+ K +Y G + + R
Sbjct: 261 --SFMTKQDTTGKIISIDTSSLRAAGRTGWE--DLVRKCIYAFFQPQGREPSYARQLFQE 316
Query: 284 LLVKGQVTTKYYRLLSKRG 302
++ +G ++ YR + G
Sbjct: 317 VMTRGTASSPSYRFILNDG 335
>gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens]
Length = 1441
Score = 83.2 bits (204), Expect = 6e-16
Identities = 82/319 (25%), Positives = 142/319 (44%), Gaps = 32/319 (10%)
Query: 5 SKNAAKTRREKENGEFYELAKLLPLP----SAITSQLDKASIIRLTTSYLKMRAVFPEGL 60
+ + K RRE+EN ELA+LL +++ + DK I++ T +++ +
Sbjct: 28 ASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEK 87
Query: 61 G---DAWGQPSRAGPLDGVAKE--LGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLS 115
D + + GV ++ LG LL+ LDGF FVV +G+I+++SE + +LG +
Sbjct: 88 STTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYN 147
Query: 116 QVELTGNSIYEYIHPSDHDEMTAVLTAHQPLHH-HLLQEYEIERSFFLRMKCVLAKRNAG 174
Q EL S+Y +H DH E L ++ QE S + ++ +
Sbjct: 148 QEELMNTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPDEP 207
Query: 175 LT-----CSGYKVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLP-PSAITEIKLY 228
T C Y+V+ C + + D + SC L+ + + LP P AIT ++
Sbjct: 208 GTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQSC-----LICIARRLPRPPAITGVE-- 260
Query: 229 SNMFMFRASLDLKLIFLDS---RVTEVTGYEPQDLIEKTLY--HHVHGCDVFHLRYAHHL 283
FM + K+I +D+ R TG+E DL+ K +Y G + + R
Sbjct: 261 --SFMTKQDTTGKIISIDTSSLRAAGRTGWE--DLVRKCIYAFFQPQGREPSYARQLFQE 316
Query: 284 LLVKGQVTTKYYRLLSKRG 302
++ +G ++ YR + G
Sbjct: 317 VMTRGTASSPSYRFILNDG 335
>gi|30795240 aryl hydrocarbon receptor nuclear translocator isoform
2 [Homo sapiens]
Length = 328
Score = 68.6 bits (166), Expect = 2e-11
Identities = 57/228 (25%), Positives = 102/228 (44%), Gaps = 44/228 (19%)
Query: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61
+E + RR K EL+ ++P SA+ + DK +I+R+ S++K
Sbjct: 91 RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTST 150
Query: 62 DAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASD-GKIMYISETASVHLGLSQVELT 120
D +PS +EL +L+ DGF+F+V+ + G+++Y+S++ + L Q E
Sbjct: 151 DGSYKPSFL-----TDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWF 205
Query: 121 GNSIYEYIHPSDHDEMTAVL-TAHQPLHHHLL-----------QEYEI------ERSFFL 162
G+++Y+ +HP D D++ L T+ L +L Q+ + RSF
Sbjct: 206 GSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFIC 265
Query: 163 RMKCVLA-----------------KRNAGLTCSG---YKVIHCSGYLK 190
RM+C + + G G + V+HC+GY+K
Sbjct: 266 RMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIK 313
>gi|5729858 nuclear receptor coactivator 2 [Homo sapiens]
Length = 1464
Score = 68.2 bits (165), Expect = 2e-11
Identities = 82/355 (23%), Positives = 146/355 (41%), Gaps = 36/355 (10%)
Query: 6 KNAAKTRREKENGEFYELAKLLPLP----SAITSQLDKASIIRLTTSYL-------KMRA 54
+N K RE+EN ELA+L+ + DK +I++ T + K A
Sbjct: 32 RNTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIKEQEKAAA 91
Query: 55 VFPEGLGDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGL 114
+ + + + G +D A LG +L+ LDGF FVV +G ++++SE + +L
Sbjct: 92 ANIDEVQKSDVSSTGQGVIDKDA--LGPMMLEALDGFFFVVNLEGNVVFVSENVTQYLRY 149
Query: 115 SQVELTGNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAG 174
+Q EL S+Y +H DH E L ++ R+ +L K
Sbjct: 150 NQEELMNKSVYSILHVGDHTEFVKNLLPKSIVNGGSWSGEPPRRNSHTFNCRMLVKPLPD 209
Query: 175 LTCSG---------YKVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEI 225
G Y+ + C + + + SC L+ V + +P +
Sbjct: 210 SEEEGHDNQEAHQKYETMQCFAVSQPKSIKEEGEDLQSC-----LICVARRVPMKE-RPV 263
Query: 226 KLYSNMFMFRASLDLKLIFLDS---RVTEVTGYEPQDLIEKTL--YHHVH-GCDVFHLRY 279
S F R L K+ LD+ R G+E DL+ + + +H H G V + +
Sbjct: 264 LPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWE--DLVRRCIQKFHAQHEGESVSYAKR 321
Query: 280 AHHLLLVKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTE 334
HH +L +G ++ YR G V Q+ + ++ + ++ P ++S++ + E
Sbjct: 322 HHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQTTNEPQLVISLHMLHRE 376
>gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens]
Length = 1424
Score = 58.9 bits (141), Expect = 1e-08
Identities = 83/352 (23%), Positives = 144/352 (40%), Gaps = 41/352 (11%)
Query: 10 KTRREKENGEFYELAKLLPLPSAITSQLD-------KASIIRLTTSYLKMRAVFPEGLGD 62
K RRE+E+ ELA+L+ SA S +D K +I++ T ++R + +G
Sbjct: 35 KRRREQESKYIEELAELI---SANLSDIDNFNVKPDKCAILKETVR--QIRQIKEQGKTI 89
Query: 63 AWGQPSRAGPLDGVAK------ELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQ 116
+ + + + LG LLQ LDGF+FVV DG I+++SE + +L Q
Sbjct: 90 SNDDDVQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQ 149
Query: 117 VELTGNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERS--FFLRMKC-----VLA 169
+L S+Y +H D + L E + ++S F RM +L
Sbjct: 150 EDLVNTSVYNILHEEDRKDFLKNLPKSTVNGVSWTNETQRQKSHTFNCRMLMKTPHDILE 209
Query: 170 KRNAGLTC-SGYKVIHCSGYLKIRQYMLDMSLYDSCYQIVG-LVAVGQSLPPSAITEIKL 227
NA Y+ + C + R M + SC V + G+ PS
Sbjct: 210 DINASPEMRQRYETMQCFALSQPRAMMEEGEDLQSCMICVARRITTGERTFPS------- 262
Query: 228 YSNMFMFRASLDLKLIFLDS---RVTEVTGYEPQDLIEKTL--YHHVHGCDVFHLRYAHH 282
F+ R L K++ +D+ R + G+E D+I + + + ++ + + +
Sbjct: 263 NPESFITRHDLSGKVVNIDTNSLRSSMRPGFE--DIIRRCIQRFFSLNDGQSWSQKRHYQ 320
Query: 283 LLLVKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTE 334
+ G T YR G V Q+ + + N ++ H VS +++ E
Sbjct: 321 EAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRNPVTNDRHGFVSTHFLQRE 372
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.132 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,171,984
Number of Sequences: 37866
Number of extensions: 1143929
Number of successful extensions: 4844
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 38
Number of HSP's successfully gapped in prelim test: 66
Number of HSP's that attempted gapping in prelim test: 4594
Number of HSP's gapped (non-prelim): 222
length of query: 570
length of database: 18,247,518
effective HSP length: 108
effective length of query: 462
effective length of database: 14,157,990
effective search space: 6540991380
effective search space used: 6540991380
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.