Search of human proteins with 191250771

Search of human proteins with 191250771

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|191250771 spire homolog 1 isoform b [Homo sapiens]
         (742 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|191250771 spire homolog 1 isoform b [Homo sapiens]                1487   0.0  
gi|191250773 spire homolog 1 isoform a [Homo sapiens]                1477   0.0  
gi|191250775 spire homolog 1 isoform c [Homo sapiens]                1242   0.0  
gi|55749600 spire homolog 2 [Homo sapiens]                            508   e-144
gi|116268127 kinase non-catalytic C-lobe domain (KIND) containin...    44   5e-04
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     42   0.002
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        41   0.005
gi|58082089 hypothetical protein LOC161394 [Homo sapiens]              40   0.006
gi|51871374 UTP14, U3 small nucleolar ribonucleoprotein, homolog...    40   0.010
gi|61966703 NHS-like 2 [Homo sapiens]                                  40   0.010
gi|238624188 diffuse panbronchiolitis critical region 1 protein ...    39   0.017
gi|61966919 hypothetical protein LOC442444 [Homo sapiens]              39   0.017
gi|239740773 PREDICTED: similar to diffuse panbronchiolitis crit...    39   0.023
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   38   0.030
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   38   0.030
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   38   0.030
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    38   0.030
gi|57222568 myeloid/lymphoid or mixed-lineage leukemia (trithora...    38   0.039
gi|24497609 nucleoporin 62kDa [Homo sapiens]                           37   0.051
gi|24497607 nucleoporin 62kDa [Homo sapiens]                           37   0.051
gi|24497605 nucleoporin 62kDa [Homo sapiens]                           37   0.051
gi|24497603 nucleoporin 62kDa [Homo sapiens]                           37   0.051
gi|110349719 titin isoform N2-A [Homo sapiens]                         37   0.066
gi|38569480 megakaryoblastic leukemia 2 protein [Homo sapiens]         37   0.066
gi|114431248 hypothetical protein LOC205717 [Homo sapiens]             37   0.087
gi|239751395 PREDICTED: hypothetical protein, partial [Homo sapi...    37   0.087
gi|239745904 PREDICTED: hypothetical protein, partial [Homo sapi...    37   0.087
gi|226371669 discs large homolog 7 isoform b [Homo sapiens]            37   0.087
gi|226371667 discs large homolog 7 isoform a [Homo sapiens]            37   0.087
gi|118421085 leucine-rich repeat kinase 1 [Homo sapiens]               36   0.11 

>gi|191250771 spire homolog 1 isoform b [Homo sapiens]
          Length = 742

 Score = 1487 bits (3850), Expect = 0.0
 Identities = 742/742 (100%), Positives = 742/742 (100%)

Query: 1   MAQAAGPAGGGEPRTEAVGGEGPREPGAAGGAAGGSRDALSLEEILRLYNQPINEEQAWA 60
           MAQAAGPAGGGEPRTEAVGGEGPREPGAAGGAAGGSRDALSLEEILRLYNQPINEEQAWA
Sbjct: 1   MAQAAGPAGGGEPRTEAVGGEGPREPGAAGGAAGGSRDALSLEEILRLYNQPINEEQAWA 60

Query: 61  VCYQCCGSLRAAARRRQPRHRVRSAAQIRVWRDGAVTLAPAADDAGEPPPVAGKLGYSQC 120
           VCYQCCGSLRAAARRRQPRHRVRSAAQIRVWRDGAVTLAPAADDAGEPPPVAGKLGYSQC
Sbjct: 61  VCYQCCGSLRAAARRRQPRHRVRSAAQIRVWRDGAVTLAPAADDAGEPPPVAGKLGYSQC 120

Query: 121 METEVIESLGIIIYKALDYGLKENEERELSPPLEQLIDHMANTVEADGSNDEGYEAAEEG 180
           METEVIESLGIIIYKALDYGLKENEERELSPPLEQLIDHMANTVEADGSNDEGYEAAEEG
Sbjct: 121 METEVIESLGIIIYKALDYGLKENEERELSPPLEQLIDHMANTVEADGSNDEGYEAAEEG 180

Query: 181 LGDEDEKRKISAIRSYRDVMKLCAAHLPTESDAPNHYQAVCRALFAETMELHTFLTKIKS 240
           LGDEDEKRKISAIRSYRDVMKLCAAHLPTESDAPNHYQAVCRALFAETMELHTFLTKIKS
Sbjct: 181 LGDEDEKRKISAIRSYRDVMKLCAAHLPTESDAPNHYQAVCRALFAETMELHTFLTKIKS 240

Query: 241 AKENLKKIQEMEKSDESSTDLEELKNADWARFWVQVMRDLRNGVKLKKVQERQYNPLPIE 300
           AKENLKKIQEMEKSDESSTDLEELKNADWARFWVQVMRDLRNGVKLKKVQERQYNPLPIE
Sbjct: 241 AKENLKKIQEMEKSDESSTDLEELKNADWARFWVQVMRDLRNGVKLKKVQERQYNPLPIE 300

Query: 301 YQLTPYEMLMDDIRCKRYTLRKVMVNGDIPPRLKKSAHEIILDFIRSRPPLNPVSARKLK 360
           YQLTPYEMLMDDIRCKRYTLRKVMVNGDIPPRLKKSAHEIILDFIRSRPPLNPVSARKLK
Sbjct: 301 YQLTPYEMLMDDIRCKRYTLRKVMVNGDIPPRLKKSAHEIILDFIRSRPPLNPVSARKLK 360

Query: 361 PTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRLDVTTPESTKNLVESSMVNGGLTSQ 420
           PTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRLDVTTPESTKNLVESSMVNGGLTSQ
Sbjct: 361 PTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRLDVTTPESTKNLVESSMVNGGLTSQ 420

Query: 421 TKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHKSTSSSSVSPSFPEEPVLEAV 480
           TKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHKSTSSSSVSPSFPEEPVLEAV
Sbjct: 421 TKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHKSTSSSSVSPSFPEEPVLEAV 480

Query: 481 STRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVRQFLPPSRQSSRSLEEFCYPVE 540
           STRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVRQFLPPSRQSSRSLEEFCYPVE
Sbjct: 481 STRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVRQFLPPSRQSSRSLEEFCYPVE 540

Query: 541 CLALTVEEVMHIRQVLVKAELEKYQQYKDIYTALKKGKLCFCCRTRRFSFFTWSYTCQFC 600
           CLALTVEEVMHIRQVLVKAELEKYQQYKDIYTALKKGKLCFCCRTRRFSFFTWSYTCQFC
Sbjct: 541 CLALTVEEVMHIRQVLVKAELEKYQQYKDIYTALKKGKLCFCCRTRRFSFFTWSYTCQFC 600

Query: 601 KRPVCSQCCKKMRLPSKPYSTLPIFSLGPSALQRGESSMRSEKPSTAHHRPLRSIARFSS 660
           KRPVCSQCCKKMRLPSKPYSTLPIFSLGPSALQRGESSMRSEKPSTAHHRPLRSIARFSS
Sbjct: 601 KRPVCSQCCKKMRLPSKPYSTLPIFSLGPSALQRGESSMRSEKPSTAHHRPLRSIARFSS 660

Query: 661 KSKSMDKSDEELQFPKELMEDWSTMEVCVDCKKFISEIISSSRRSLVLANKRARLKRKTQ 720
           KSKSMDKSDEELQFPKELMEDWSTMEVCVDCKKFISEIISSSRRSLVLANKRARLKRKTQ
Sbjct: 661 KSKSMDKSDEELQFPKELMEDWSTMEVCVDCKKFISEIISSSRRSLVLANKRARLKRKTQ 720

Query: 721 SFYMSSPGPSEYCPSERTISEI 742
           SFYMSSPGPSEYCPSERTISEI
Sbjct: 721 SFYMSSPGPSEYCPSERTISEI 742


>gi|191250773 spire homolog 1 isoform a [Homo sapiens]
          Length = 756

 Score = 1478 bits (3825), Expect = 0.0
 Identities = 742/756 (98%), Positives = 742/756 (98%), Gaps = 14/756 (1%)

Query: 1   MAQAAGPAGGGEPRTEAVGGEGPREPGAAGGAAGGSRDALSLEEILRLYNQPINEEQAWA 60
           MAQAAGPAGGGEPRTEAVGGEGPREPGAAGGAAGGSRDALSLEEILRLYNQPINEEQAWA
Sbjct: 1   MAQAAGPAGGGEPRTEAVGGEGPREPGAAGGAAGGSRDALSLEEILRLYNQPINEEQAWA 60

Query: 61  VCYQCCGSLRAAARRRQPRHRVRSAAQIRVWRDGAVTLAPAADDAGEPPPVAGKLGYSQC 120
           VCYQCCGSLRAAARRRQPRHRVRSAAQIRVWRDGAVTLAPAADDAGEPPPVAGKLGYSQC
Sbjct: 61  VCYQCCGSLRAAARRRQPRHRVRSAAQIRVWRDGAVTLAPAADDAGEPPPVAGKLGYSQC 120

Query: 121 METEVIESLGIIIYKALDYGLKENEERELSPPLEQLIDHMANTVEADGSNDEGYEAAEEG 180
           METEVIESLGIIIYKALDYGLKENEERELSPPLEQLIDHMANTVEADGSNDEGYEAAEEG
Sbjct: 121 METEVIESLGIIIYKALDYGLKENEERELSPPLEQLIDHMANTVEADGSNDEGYEAAEEG 180

Query: 181 LGDEDEKRKISAIRSYRDVMKLCAAHLPTESDAPNHYQAVCRALFAETMELHTFLTKIKS 240
           LGDEDEKRKISAIRSYRDVMKLCAAHLPTESDAPNHYQAVCRALFAETMELHTFLTKIKS
Sbjct: 181 LGDEDEKRKISAIRSYRDVMKLCAAHLPTESDAPNHYQAVCRALFAETMELHTFLTKIKS 240

Query: 241 AKENLKKIQEMEKSDESSTDLEELKNADWARFWVQVMRDLRNGVKLKKVQERQYNPLPIE 300
           AKENLKKIQEMEKSDESSTDLEELKNADWARFWVQVMRDLRNGVKLKKVQERQYNPLPIE
Sbjct: 241 AKENLKKIQEMEKSDESSTDLEELKNADWARFWVQVMRDLRNGVKLKKVQERQYNPLPIE 300

Query: 301 YQLTPYEMLMDDIRCKRYTLRKVMVNGDIPPRLKKSAHEIILDFIRSRPPLNPVSARKLK 360
           YQLTPYEMLMDDIRCKRYTLRKVMVNGDIPPRLKKSAHEIILDFIRSRPPLNPVSARKLK
Sbjct: 301 YQLTPYEMLMDDIRCKRYTLRKVMVNGDIPPRLKKSAHEIILDFIRSRPPLNPVSARKLK 360

Query: 361 PTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRL--------------DVTTPESTKN 406
           PTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRL              DVTTPESTKN
Sbjct: 361 PTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRLAMRPLSMSYSFDLSDVTTPESTKN 420

Query: 407 LVESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHKSTSSSS 466
           LVESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHKSTSSSS
Sbjct: 421 LVESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHKSTSSSS 480

Query: 467 VSPSFPEEPVLEAVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVRQFLPPSR 526
           VSPSFPEEPVLEAVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVRQFLPPSR
Sbjct: 481 VSPSFPEEPVLEAVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVRQFLPPSR 540

Query: 527 QSSRSLEEFCYPVECLALTVEEVMHIRQVLVKAELEKYQQYKDIYTALKKGKLCFCCRTR 586
           QSSRSLEEFCYPVECLALTVEEVMHIRQVLVKAELEKYQQYKDIYTALKKGKLCFCCRTR
Sbjct: 541 QSSRSLEEFCYPVECLALTVEEVMHIRQVLVKAELEKYQQYKDIYTALKKGKLCFCCRTR 600

Query: 587 RFSFFTWSYTCQFCKRPVCSQCCKKMRLPSKPYSTLPIFSLGPSALQRGESSMRSEKPST 646
           RFSFFTWSYTCQFCKRPVCSQCCKKMRLPSKPYSTLPIFSLGPSALQRGESSMRSEKPST
Sbjct: 601 RFSFFTWSYTCQFCKRPVCSQCCKKMRLPSKPYSTLPIFSLGPSALQRGESSMRSEKPST 660

Query: 647 AHHRPLRSIARFSSKSKSMDKSDEELQFPKELMEDWSTMEVCVDCKKFISEIISSSRRSL 706
           AHHRPLRSIARFSSKSKSMDKSDEELQFPKELMEDWSTMEVCVDCKKFISEIISSSRRSL
Sbjct: 661 AHHRPLRSIARFSSKSKSMDKSDEELQFPKELMEDWSTMEVCVDCKKFISEIISSSRRSL 720

Query: 707 VLANKRARLKRKTQSFYMSSPGPSEYCPSERTISEI 742
           VLANKRARLKRKTQSFYMSSPGPSEYCPSERTISEI
Sbjct: 721 VLANKRARLKRKTQSFYMSSPGPSEYCPSERTISEI 756


>gi|191250775 spire homolog 1 isoform c [Homo sapiens]
          Length = 622

 Score = 1242 bits (3214), Expect = 0.0
 Identities = 622/622 (100%), Positives = 622/622 (100%)

Query: 121 METEVIESLGIIIYKALDYGLKENEERELSPPLEQLIDHMANTVEADGSNDEGYEAAEEG 180
           METEVIESLGIIIYKALDYGLKENEERELSPPLEQLIDHMANTVEADGSNDEGYEAAEEG
Sbjct: 1   METEVIESLGIIIYKALDYGLKENEERELSPPLEQLIDHMANTVEADGSNDEGYEAAEEG 60

Query: 181 LGDEDEKRKISAIRSYRDVMKLCAAHLPTESDAPNHYQAVCRALFAETMELHTFLTKIKS 240
           LGDEDEKRKISAIRSYRDVMKLCAAHLPTESDAPNHYQAVCRALFAETMELHTFLTKIKS
Sbjct: 61  LGDEDEKRKISAIRSYRDVMKLCAAHLPTESDAPNHYQAVCRALFAETMELHTFLTKIKS 120

Query: 241 AKENLKKIQEMEKSDESSTDLEELKNADWARFWVQVMRDLRNGVKLKKVQERQYNPLPIE 300
           AKENLKKIQEMEKSDESSTDLEELKNADWARFWVQVMRDLRNGVKLKKVQERQYNPLPIE
Sbjct: 121 AKENLKKIQEMEKSDESSTDLEELKNADWARFWVQVMRDLRNGVKLKKVQERQYNPLPIE 180

Query: 301 YQLTPYEMLMDDIRCKRYTLRKVMVNGDIPPRLKKSAHEIILDFIRSRPPLNPVSARKLK 360
           YQLTPYEMLMDDIRCKRYTLRKVMVNGDIPPRLKKSAHEIILDFIRSRPPLNPVSARKLK
Sbjct: 181 YQLTPYEMLMDDIRCKRYTLRKVMVNGDIPPRLKKSAHEIILDFIRSRPPLNPVSARKLK 240

Query: 361 PTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRLDVTTPESTKNLVESSMVNGGLTSQ 420
           PTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRLDVTTPESTKNLVESSMVNGGLTSQ
Sbjct: 241 PTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRLDVTTPESTKNLVESSMVNGGLTSQ 300

Query: 421 TKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHKSTSSSSVSPSFPEEPVLEAV 480
           TKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHKSTSSSSVSPSFPEEPVLEAV
Sbjct: 301 TKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHKSTSSSSVSPSFPEEPVLEAV 360

Query: 481 STRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVRQFLPPSRQSSRSLEEFCYPVE 540
           STRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVRQFLPPSRQSSRSLEEFCYPVE
Sbjct: 361 STRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVRQFLPPSRQSSRSLEEFCYPVE 420

Query: 541 CLALTVEEVMHIRQVLVKAELEKYQQYKDIYTALKKGKLCFCCRTRRFSFFTWSYTCQFC 600
           CLALTVEEVMHIRQVLVKAELEKYQQYKDIYTALKKGKLCFCCRTRRFSFFTWSYTCQFC
Sbjct: 421 CLALTVEEVMHIRQVLVKAELEKYQQYKDIYTALKKGKLCFCCRTRRFSFFTWSYTCQFC 480

Query: 601 KRPVCSQCCKKMRLPSKPYSTLPIFSLGPSALQRGESSMRSEKPSTAHHRPLRSIARFSS 660
           KRPVCSQCCKKMRLPSKPYSTLPIFSLGPSALQRGESSMRSEKPSTAHHRPLRSIARFSS
Sbjct: 481 KRPVCSQCCKKMRLPSKPYSTLPIFSLGPSALQRGESSMRSEKPSTAHHRPLRSIARFSS 540

Query: 661 KSKSMDKSDEELQFPKELMEDWSTMEVCVDCKKFISEIISSSRRSLVLANKRARLKRKTQ 720
           KSKSMDKSDEELQFPKELMEDWSTMEVCVDCKKFISEIISSSRRSLVLANKRARLKRKTQ
Sbjct: 541 KSKSMDKSDEELQFPKELMEDWSTMEVCVDCKKFISEIISSSRRSLVLANKRARLKRKTQ 600

Query: 721 SFYMSSPGPSEYCPSERTISEI 742
           SFYMSSPGPSEYCPSERTISEI
Sbjct: 601 SFYMSSPGPSEYCPSERTISEI 622


>gi|55749600 spire homolog 2 [Homo sapiens]
          Length = 714

 Score =  508 bits (1309), Expect = e-144
 Identities = 312/738 (42%), Positives = 428/738 (57%), Gaps = 77/738 (10%)

Query: 27  GAAGGAAGGSRDA----LSLEEILRLYNQPINEEQAWAVCYQCCGSLRAAARRRQPRHRV 82
           G+ GGAA G+       LSLEE+L+ Y QP+NEEQAWAVC+Q C  LR +     P  R+
Sbjct: 5   GSCGGAAAGAGRPEPWELSLEEVLKAYEQPLNEEQAWAVCFQGCRGLRGS-----PGRRL 59

Query: 83  RSAAQIRVWRDGAVTLAPAADDAGEPPPVAGKLGYSQCMETEVIESLGIIIYKALDYGLK 142
           R    + +  DG+V       +A EP  +   L  S   E + ++SLG  IY+ALD+GL 
Sbjct: 60  RDTGDLLLRGDGSV--GAREPEAAEPATMVVPLASS---EAQTVQSLGFAIYRALDWGLD 114

Query: 143 ENEERELSPPLEQLIDHMANTVEADGSNDEGYEAAEEGLGDEDEKRKIS----AIRSYRD 198
           E+EERELSP LE+LID MAN    + S D G  AA+EG G  +E+ +      ++R++  
Sbjct: 115 ESEERELSPQLERLIDLMAN----NDSEDSGCGAADEGYGGPEEEEEAEGVPRSVRTFAQ 170

Query: 199 VMKLCAAHLPTESDAPNHYQAVCRALFAETMELHTFLTKIKSAKENLKKIQEMEKSDESS 258
            M+LCAA L     A  HYQAVCRALF ET+EL  FL +++ AKE L+K++E E   E+ 
Sbjct: 171 AMRLCAARLTDPRGAQAHYQAVCRALFVETLELRAFLARVREAKEMLQKLREDEPHLETP 230

Query: 259 -TDLEELKNADWARFWVQVMRDLRNGVKLKKVQERQYNPLPIEYQLTPYEMLMDDIRCKR 317
             +L+ L + DWAR WVQ+MR+LR GVKLKKVQE+++NPLP E+QLTP+EMLM DIR + 
Sbjct: 231 RAELDSLGHTDWARLWVQLMRELRRGVKLKKVQEQEFNPLPTEFQLTPFEMLMQDIRARN 290

Query: 318 YTLRKVMVNGDIPPRLKKSAHEIILDFIRSRPPLNPVSARKLKPTPPRPRSLHERILEEI 377
           Y LRKVMV+GDIPPR+KK AHE+ILDFIRSRPPL  VS R+L+P PP+ RSLHE+ILEEI
Sbjct: 291 YKLRKVMVDGDIPPRVKKDAHELILDFIRSRPPLKQVSERRLRPLPPKQRSLHEKILEEI 350

Query: 378 KAERKLRPVSPEEIRR---SRLDVTTPESTKNLVESSMVNGGLTSQTKENGLSTSQQVPA 434
           K ER+LRPV  E         L       + +   +S +N  +T    + G S  +  P 
Sbjct: 351 KQERRLRPVRGEGWAARGFGSLPCILNACSGDAKSTSCINLSVT----DAGGSAQRPRP- 405

Query: 435 QRKKLLRAPTLAELDSSESEEE--------TLHKSTSSSSVSPSFPEEPVLEAVSTRKKP 486
             + LL+APTLAE++   + EE        TL +  S S    +     V   + +   P
Sbjct: 406 --RVLLKAPTLAEMEEMNTSEEEESPCGEVTLKRDRSFSEHDLAQLRSEVASGLQSATHP 463

Query: 487 PKFLPISSTPQPERR-------QPPQRRHSIEKETPTNVRQFLPPSRQSSRSLE------ 533
           P       T  P  R       +P  R       + ++    L  +R SS          
Sbjct: 464 P-----GGTEPPRPRAGSAHVWRPGSRDQGTCPASVSDPSHPLLSNRGSSGDRPEASMTP 518

Query: 534 -------EFCYPVECLALTVEEVMHIRQVLVKAELEKYQQYKDIYTALKKGKLCFCCRTR 586
                  EF +PVE LALTVEEVM +R+VLVKAE+EK+ Q K+++++LKKGK+C CCR  
Sbjct: 519 DAKHLWLEFSHPVESLALTVEEVMDVRRVLVKAEMEKFLQNKELFSSLKKGKICCCCRA- 577

Query: 587 RFSFFTWSYTCQFCKRPVCSQCCKKMRLPSKPYSTLPIFSLGPSALQRGESSMRSEKPST 646
           +F  F+W  +C FCKR VC+ C  KM++PSK +  +P+++LG  + QR          S 
Sbjct: 578 KFPLFSWPPSCLFCKRAVCTSCSIKMKMPSKKFGHIPVYTLGFESPQR---------VSA 628

Query: 647 AHHRPLRSIARFSSKSKSMDKSDEELQFPKELMEDWSTMEVCVDCKKFISEIISSSRRSL 706
           A   P++    F S      +S EE  FP          +VC +C  F+++++ SSR+S+
Sbjct: 629 AKTAPIQRRDIFQSLQGPQWQSVEE-AFPHIYSHGCVLKDVCSECTSFVADVVRSSRKSV 687

Query: 707 VLANKRARLKRKTQSFYM 724
            + N   R  R+TQS Y+
Sbjct: 688 DVLNTTPRRSRQTQSLYI 705


>gi|116268127 kinase non-catalytic C-lobe domain (KIND) containing 1
           isoform a [Homo sapiens]
          Length = 1749

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 34/121 (28%), Positives = 54/121 (44%)

Query: 40  LSLEEILRLYNQPINEEQAWAVCYQCCGSLRAAARRRQPRHRVRSAAQIRVWRDGAVTLA 99
           +SL +IL L ++ ++E++AWAVC +C  S+R+ A     +    +   +     G V   
Sbjct: 37  VSLADILSLRDRGLSEQEAWAVCLECSLSMRSVAHAAIFQSLCITPDTLAFNTSGNVCFM 96

Query: 100 PAADDAGEPPPVAGKLGYSQCMETEVIESLGIIIYKALDYGLKENEERELSPPLEQLIDH 159
               D  E   V  +   +       I SLG  +  AL+Y  +   E  LS  LE L+  
Sbjct: 97  EQLSDDPEGAFVPPEFDVTGNTFEAHIYSLGATLKAALEYVAEPTLEPRLSQDLEALLSR 156

Query: 160 M 160
           M
Sbjct: 157 M 157



 Score = 38.1 bits (87), Expect = 0.030
 Identities = 41/179 (22%), Positives = 71/179 (39%), Gaps = 29/179 (16%)

Query: 7   PAGGGEPRTEAVG---GEGPREPGAAGGAAGGSRDA------------------LSLEEI 45
           P   G+P T        E P +P  A G A   RD                   +SL+++
Sbjct: 390 PGSPGQPETSHPSQGPAEAPADPRDASGEAQTPRDDERIPEGARQLESAAAEQWVSLQDL 449

Query: 46  LRLYNQPINEEQAWAVCYQCCGSLRAAARRRQPRHRVRSAA-QIRVWRDGAVTL-APAAD 103
           L    +P  E + WA+C  C  +L+      +P H        + V  DGAV    P A+
Sbjct: 450 LSQLGRPFREYELWALCLACLRALQT-----RPEHPAYLCLDSVLVAEDGAVLFQPPPAN 504

Query: 104 DAGEPPPVAGKLGYSQCM-ETEVIESLGIIIYKALDYGLKENEERELSPPLEQLIDHMA 161
            + +   +A +L   + + E   +  +  +++ A  + +  N +  L   L+ L+  MA
Sbjct: 505 GSYDSFFLAPELAEERLVTEKASVYCVAAVLWTAAKFSVPRNHKLALPRRLKTLLLDMA 563


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 42.4 bits (98), Expect = 0.002
 Identities = 69/326 (21%), Positives = 120/326 (36%), Gaps = 58/326 (17%)

Query: 222 RALFAETMELHTFLTKIKSAKENLKKIQEMEKSDESSTDLEELKNADWARFWVQVMRDLR 281
           R L A T EL      +KS K++L++ Q  E  D    D+   + A       Q+  +LR
Sbjct: 323 RQLQARTTELEA----LKSTKDSLER-QRSELEDRHQADIASYQEAIQ-----QLDAELR 372

Query: 282 NGVKLKKVQERQYNPL-----PIEYQLTPYEMLMDDIRCKRYTLRKVMVNGDIPPRLKKS 336
           N       Q R+Y  L      ++ ++  Y  L++   C+       +  G IP  L + 
Sbjct: 373 NTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECR-------IGFGPIPFSLPEG 425

Query: 337 AHEIILDFIRSRPPLNPVSARKLKPTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRL 396
             +I            P  +  +K                +K+E K++ V   E     +
Sbjct: 426 LPKI------------PSVSTHIK----------------VKSEEKIKVVEKSEKETVIV 457

Query: 397 DVTTPES--TKNLVESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESE 454
           +  T E+  T+ + E            +E G    +    + +   ++P   E  S E E
Sbjct: 458 EEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEET--KSPPAEEAASPEKE 515

Query: 455 EETLHKSTSSSSVSPSFPEEPVLEAVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEKET 514
            ++  K  + S      PE+   ++ +  K P K    + +P  E  + P    S EKE 
Sbjct: 516 AKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEK----AKSPAKEEAKSPPEAKSPEKEE 571

Query: 515 PTNVRQFLPPSRQSSRSLEEFCYPVE 540
             +  +   P +  S + EE   P E
Sbjct: 572 AKSPAEVKSPEKAKSPAKEEAKSPAE 597



 Score = 37.7 bits (86), Expect = 0.039
 Identities = 37/179 (20%), Positives = 72/179 (40%), Gaps = 8/179 (4%)

Query: 373 ILEEIKAERKLRPVSPEEIRRSRLDVTTPESTKNLVESSMVNGGLTSQTKENGLSTSQQV 432
           + EE K+  + +    EE + S  +V +PE  K+  +    +       ++    +  +V
Sbjct: 520 VKEEAKSPAEAKSPEKEEAK-SPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEV 578

Query: 433 PAQRKKLLRAPTLAELDSSESEEETLHKSTSSSSVSPSFPEEPVLEAVSTR---KKPPKF 489
            +  K    A   A+  +     E         + SP+  + PV E   +    K P K 
Sbjct: 579 KSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEK- 637

Query: 490 LPISSTPQPERRQPPQRRHSIEKETPTNVRQFLPPSRQSSRSLEEFCYPVECLALTVEE 548
              + +P  E  + P++  S EKE   +  +   P +  ++S E+   PV+  A + E+
Sbjct: 638 ---AKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEK 693



 Score = 37.7 bits (86), Expect = 0.039
 Identities = 42/191 (21%), Positives = 76/191 (39%), Gaps = 16/191 (8%)

Query: 358 KLKPTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRLDVTTPESTKNLV-ESSMVNGG 416
           K  P    P     +   E+K+  K +  + EE + S  +  +PE  K+ V E +     
Sbjct: 559 KSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAK-SPAEAKSPEKAKSPVKEEAKSPAE 617

Query: 417 LTSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSES-------EEETLHKSTSSSSVSP 469
             S  KE   S ++    ++ K   +PT  E  S E        E ++  K+ S      
Sbjct: 618 AKSPVKEEAKSPAEVKSPEKAK---SPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEA 674

Query: 470 SFPEEPVLEAVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVRQFLPPSRQSS 529
             PE+      +  K P K    + +P  E  + P++  S  KE   +  +   P ++ +
Sbjct: 675 KSPEKAKSPVKAEAKSPEK----AKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEA 730

Query: 530 RSLEEFCYPVE 540
           ++ E+   PV+
Sbjct: 731 KTPEKAKSPVK 741



 Score = 30.4 bits (67), Expect = 6.2
 Identities = 38/198 (19%), Positives = 81/198 (40%), Gaps = 5/198 (2%)

Query: 375 EEIKAERKLRPVSPEEIRRS-RLDVTTPESTKNLVESSMVNGGLTSQTKENGLSTSQQVP 433
           E+ K+  K    SPE+ +   + +  +PE  K+ V++   +        +    + ++  
Sbjct: 650 EKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAK 709

Query: 434 AQRKKLLRAPTLAELDSSESEEETLHKSTS---SSSVSPSFPEEPVLEAVSTRKKPPKFL 490
           +  K+  ++P  A+    E E +T  K+ S     + SP   + P        K P    
Sbjct: 710 SPVKEEAKSPEKAKSPVKE-EAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKT 768

Query: 491 PISSTPQPERRQPPQRRHSIEKETPTNVRQFLPPSRQSSRSLEEFCYPVECLALTVEEVM 550
           P     +    + P++  S  KE   +  +   P ++ +++ E+     E +   V+E  
Sbjct: 769 PAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEE 828

Query: 551 HIRQVLVKAELEKYQQYK 568
             ++V VK   +K ++ K
Sbjct: 829 KPQEVKVKEPPKKAEEEK 846


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 40.8 bits (94), Expect = 0.005
 Identities = 45/190 (23%), Positives = 70/190 (36%), Gaps = 23/190 (12%)

Query: 365 RPRSLHERILEEIKAERKLRPVSPEEIRRSRLD------VTTPESTK----NLVESSMVN 414
           R  S  ER  +   ++R+ R  S  E+++SR+       +++P S      +L  S   +
Sbjct: 723 RSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGS 782

Query: 415 GGLTSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHKSTSSSSVSPSFPEE 474
                Q  +     S+   +Q K   R P      SS    +   K+ S  S S S P  
Sbjct: 783 SPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHP 842

Query: 475 PVLEAVSTRK-------------KPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVRQF 521
            V      R+              P +     S+P PE +     RHS    +P  V+  
Sbjct: 843 KVKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPPRVKSS 902

Query: 522 LPPSRQSSRS 531
            PP +  SRS
Sbjct: 903 TPPRQSPSRS 912



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 49/191 (25%), Positives = 76/191 (39%), Gaps = 17/191 (8%)

Query: 346 RSRPPLNPVSARKLKPTP----PRPRSLHERILEEIKAERKLRPVSPEEIRRSRLDVTTP 401
           RSR P     +R   P       R R+   R     +  R+ R  S   +RR R    TP
Sbjct: 659 RSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTP 718

Query: 402 EST-KNLVESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHK 460
           +   ++   S   N   TSQ +    ++S ++   R    R+ +L+   S      +L +
Sbjct: 719 QRRGRSGSSSERKNKSRTSQRRSRS-NSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRR 777

Query: 461 STSSSSVSPSFPEEPVLEAVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVRQ 520
           S S SS  P            ++  P +    SS P+ + R PP+R  S    +P   ++
Sbjct: 778 SLSGSSPCPK---------QKSQTPPRRSRSGSSQPKAKSRTPPRRSRS--SSSPPPKQK 826

Query: 521 FLPPSRQSSRS 531
              PSRQS  S
Sbjct: 827 SKTPSRQSHSS 837



 Score = 37.0 bits (84), Expect = 0.066
 Identities = 39/163 (23%), Positives = 60/163 (36%), Gaps = 33/163 (20%)

Query: 385  PVSPEEIRRSRLDVTTPESTKNLVESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRAPT 444
            P   E +R  R    TP   K    SS  +   +S +  +  S+S               
Sbjct: 2584 PAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSS------------- 2630

Query: 445  LAELDSSESEEETLHKSTSSSSVSPSFPEEPVLEAVSTRKKPPKFLPISSTPQP------ 498
                 SS S   +   S+SSSS SP+ P    L   ++ KKPP     S +P+       
Sbjct: 2631 ----SSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLR 2686

Query: 499  ----------ERRQPPQRRHSIEKETPTNVRQFLPPSRQSSRS 531
                      ERR+P  +    ++++ ++ R      R  SRS
Sbjct: 2687 DSRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQRGDSRS 2729



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 48/210 (22%), Positives = 81/210 (38%), Gaps = 19/210 (9%)

Query: 330  PPRLKKSAHEIILDFIRSRPPLNPVSARKLKPTPPRPRSLHERILEEIKAERKLRPVSPE 389
            P R +  +   + D  R+ P     S    +P  P PR+L  R      +  K R  SPE
Sbjct: 1593 PRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRR--SRSGSSSKGRGPSPE 1650

Query: 390  EIRRSRLDVTTPESTKNLVESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRAPTL---A 446
                     +T  S ++  +S     G  S  +     T  + P +R+    +P L   A
Sbjct: 1651 G------SSSTESSPEHPPKSRTARRGSRSSPEPK---TKSRTPPRRRSSRSSPELTRKA 1701

Query: 447  ELD----SSESEEETLHKSTSSSSVSPSFPE-EPVLEAVSTRKKPPKFLPISSTPQPERR 501
             L     S+ S  ET  ++      SPS    EP  ++ S+R++     P + T     R
Sbjct: 1702 RLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGR 1761

Query: 502  QPPQRRHSIEKETPTNVRQFLPPSRQSSRS 531
             P  +   +++    + R+    +R+  RS
Sbjct: 1762 SPSPKPRGLQRSRSRSRREKTRTTRRRDRS 1791



 Score = 33.9 bits (76), Expect = 0.56
 Identities = 36/178 (20%), Positives = 65/178 (36%), Gaps = 22/178 (12%)

Query: 376 EIKAERKLRPVSPEEIRRSRLDVTTPESTKNL------VESSMVNGGLTSQTKENGLST- 428
           + K E +LR +    ++R   D+   E  + +      +E  M   G   Q  +  ++T 
Sbjct: 35  DYKGEEELRRLEAALVKRPNPDILDHERKRRVELRCLELEEMMEEQGYEEQQIQEKVATF 94

Query: 429 -------------SQQVPAQRKKLLRAPTLAELDSSESEEETLHKSTSSSSVSPSF--PE 473
                         ++ P QR  +     LAEL+  ++E        S S V  S   P+
Sbjct: 95  RLMLLEKDVNPGGKEETPGQRPAVTETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQ 154

Query: 474 EPVLEAVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVRQFLPPSRQSSRS 531
               EA     +PPK   +       R   P+++   +K+      +   P R+  +S
Sbjct: 155 RRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKS 212



 Score = 32.0 bits (71), Expect = 2.1
 Identities = 57/235 (24%), Positives = 83/235 (35%), Gaps = 34/235 (14%)

Query: 331  PRLKKSAHEII--------LDFIRSR-PPLNPVSARKLKPTPPRPRS-LHERILEEIKAE 380
            PR+  SA+E +        LD  RSR PP  P  +R      P P S + +   + +   
Sbjct: 2383 PRVPLSAYERVSGRTSPPLLDRARSRTPPSAPSQSRMTSERAPSPSSRMGQAPSQSLLPP 2442

Query: 381  RKLRPVSP-----EEIRRSRLDVTTPESTKNLVESSMVNGGLTSQTKENGL--------- 426
             + +P SP      +  R  +  TTP +    + S  V    +S    NG+         
Sbjct: 2443 AQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVP 2502

Query: 427  ---------STSQQVPAQRKKLLRAPTL-AELDSSESEEETLHKSTSSSSVSPSFPEEPV 476
                     ST  Q P+    L  A    +   SS S   +   S+SSSS S S      
Sbjct: 2503 HSDVGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSD 2562

Query: 477  LEAVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVRQFLPPSRQSSRS 531
             E  S   +P   L    +P P  ++  +     E       R+    S  SS S
Sbjct: 2563 SEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSS 2617



 Score = 30.8 bits (68), Expect = 4.8
 Identities = 46/196 (23%), Positives = 69/196 (35%), Gaps = 20/196 (10%)

Query: 346  RSRPPLNPVSARKLKPTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRLDVTTPESTK 405
            RSR   +PVS R+ +   P       R        R      P   RRSR    TP  T+
Sbjct: 1910 RSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRRRSRSRTPPVTRRRSR--SRTPPVTR 1967

Query: 406  NLVESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHKSTSSS 465
                S       +  T+    S +  V  +R +   +P       S +   T  +S S +
Sbjct: 1968 RRSRSR-----TSPITRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRT 2022

Query: 466  SVS---PSFPEEPVLEAVSTRKKPPKFL---PISSTPQPER------RQPPQ-RRHSIEK 512
              +    S    P+L    +R + P  +     S TP+  R      R PP  RR S   
Sbjct: 2023 PPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRTARGKRSLTRSPPAIRRRSASG 2082

Query: 513  ETPTNVRQFLPPSRQS 528
             +    R   PP+ ++
Sbjct: 2083 SSSDRSRSATPPATRN 2098



 Score = 30.4 bits (67), Expect = 6.2
 Identities = 34/147 (23%), Positives = 58/147 (39%), Gaps = 13/147 (8%)

Query: 387  SPEEIRRSRLDVTTPESTKNLVESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRAPTLA 446
            SPE   +SRL   +P  +++     + +    +   ++G  +S +  A   + L  P  +
Sbjct: 1582 SPEVDSKSRL---SPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRAL--PRRS 1636

Query: 447  ELDSSESEEETLHKSTSSSSVSPSFPEEPVLEAVSTRKKPPKFLPISSTPQPERRQPPQR 506
               SS        + +SS+  SP  P +       +R  P         P+ + R PP+R
Sbjct: 1637 RSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPE--------PKTKSRTPPRR 1688

Query: 507  RHSIEKETPTNVRQFLPPSRQSSRSLE 533
            R S      T   +    SR +S S E
Sbjct: 1689 RSSRSSPELTRKARLSRRSRSASSSPE 1715


>gi|58082089 hypothetical protein LOC161394 [Homo sapiens]
          Length = 674

 Score = 40.4 bits (93), Expect = 0.006
 Identities = 53/208 (25%), Positives = 74/208 (35%), Gaps = 22/208 (10%)

Query: 359 LKPTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRLDVTTPESTKNLVESSMVNG--- 415
           L+P      ++ E +  E   E    PV P E        T  E    L+E     G   
Sbjct: 135 LEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGATVRERNLELLEEETEPGVPE 194

Query: 416 -GLTSQTKENGLSTSQQVPAQRKKLLRAPTLAELD-------SSESEEETLHKSTSSSSV 467
             L  Q +E GL   +Q            +L E D         E+ EET  +ST     
Sbjct: 195 ESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEETQRESTEKKRT 254

Query: 468 SPSFPEEPVLEAVSTRKKPPKFLPISSTPQPERRQPP-----QRRHSIEK--ETPTNVRQ 520
            P  PE+  LE +   K+P K    +    PE  QP      QR+ + EK  E P   + 
Sbjct: 255 EP--PEQARLEFL--EKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTELPERTKP 310

Query: 521 FLPPSRQSSRSLEEFCYPVECLALTVEE 548
             P  +    + E    P+E + L   E
Sbjct: 311 DFPDHKPRKSTDENVPEPLEEIKLEFPE 338


>gi|51871374 UTP14, U3 small nucleolar ribonucleoprotein, homolog C
           [Homo sapiens]
          Length = 766

 Score = 39.7 bits (91), Expect = 0.010
 Identities = 84/393 (21%), Positives = 151/393 (38%), Gaps = 49/393 (12%)

Query: 201 KLCAAHLPTESDAPNHYQAVCRALFAETMELHTFLTKIKSAKENLKKIQEMEKSDESSTD 260
           K+  A L       ++Y+A  R       + +  + K   AK+ LK+ ++++K + +   
Sbjct: 220 KMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVA- 278

Query: 261 LEELKNADWARFWVQVMRDLRNGVKLKKVQERQYNPLPIEYQLTPYEMLMDDIRCKRYTL 320
           LEE++  + AR   ++    +N  K  K +      +  +Y L   + + + +   +   
Sbjct: 279 LEEMEKIENARMMERMSLKHQNSGKWAKSKA-----IMAKYDLEARQAMQEQLAKNKELT 333

Query: 321 RKVMVNGDIPPRLKKS-AHEIILDFIRSRPPLNP-----------VSARKLKPTPPRPRS 368
           +K+ V  +       +   E+++  + +   +N             S  K   T   P  
Sbjct: 334 QKLQVASESEEEEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQ 393

Query: 369 LHERILEEIKA-ERKLRPVSPEEI------------RRSRLDVTT-PESTKNLVESSMVN 414
           + E    E+ A E + RPV+ EEI            +RS L+    P S++   +SS   
Sbjct: 394 VPELAAHEVSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPASSQETKDSSSQE 453

Query: 415 -----GGLTSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHKSTSSSSVSP 469
                  L+ + KE   S  Q+  ++       P +   + +  E E L    S    + 
Sbjct: 454 VLSELRALSQKLKEKHQSRKQKASSEGT----VPQVQREEPAPEEAEPLLLQRSERVQTL 509

Query: 470 SFPEEPVLEAVSTRKKPPKFLPISSTPQPER---RQPPQRRHSIEKETPTNVRQFLPPSR 526
              EE   E     K+ P+  P+    Q ER    +P   +   EKE   N++ FL    
Sbjct: 510 EELEELGKEDCFQNKELPR--PVLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQS 567

Query: 527 QSSRSLEEFCYPVECLALTVEEVMHIRQVLVKA 559
            S RSL     P     L  EE    RQ++ +A
Sbjct: 568 PSVRSL---AVPTIIEELEDEEERDQRQMIKEA 597


>gi|61966703 NHS-like 2 [Homo sapiens]
          Length = 709

 Score = 39.7 bits (91), Expect = 0.010
 Identities = 55/223 (24%), Positives = 91/223 (40%), Gaps = 43/223 (19%)

Query: 350 PLNPVSARKLKPTPPRPRSLHERILEEIKAERKLRPVSPE------------EIRRSRLD 397
           P +  S++   PTP    SL    L    +  ++RPV PE            +  +SRL 
Sbjct: 345 PSSGYSSQSETPTPTVSMSLTLGHLPPPSSSVRVRPVVPERKSSLPPTSPMEKFPKSRLS 404

Query: 398 VTTPESTKNLVESSMVNGGLTSQTKEN--------GLSTSQQ-------VPAQRKKLLRA 442
              P ++   ++ S ++  + S+TK +        G+  +Q+       +P   +  LR+
Sbjct: 405 FDLPLTSSPNLDLSGMSISIRSKTKVSRHHSETNFGVKLAQKTNPNQPIMPMVTQSDLRS 464

Query: 443 PTLAELDSSESEEETLHKSTSSSSVSPSFPEEPVLEAVSTRKKPPKFLPISSTPQPERRQ 502
             L  +  SE E++           SP + EEP  E V T  +     P++  P P  R+
Sbjct: 465 VRLRSVSKSEPEDDI---------ESPEYAEEPRAEEVFTLPERKTKPPVAEKP-PVARR 514

Query: 503 PPQRRHS----IEKETPTNVRQFLPP--SRQSSRSLEEFCYPV 539
           PP   H      E+   T+    +PP  S Q +R L +  Y V
Sbjct: 515 PPSLVHKPPSVPEEYALTSPTLAMPPRSSIQHARPLPQDSYTV 557


>gi|238624188 diffuse panbronchiolitis critical region 1 protein
           [Homo sapiens]
          Length = 1393

 Score = 38.9 bits (89), Expect = 0.017
 Identities = 40/172 (23%), Positives = 64/172 (37%), Gaps = 10/172 (5%)

Query: 358 KLKPTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRLDVTTPESTKNLVESSMVNGGL 417
           K  P P  P    ER   E        P  P E    R  +   ++T +L E +  NG  
Sbjct: 732 KTTPFPAEPTENRERTANENTTPS---PAQPTE-NGDRTPLANEKTTPSLAEPTE-NGKR 786

Query: 418 TSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHKSTSSSSVSPSFPEEPVL 477
           T    E   S+S + P +  +  R P   E  +S   E T ++  +++  +  FP EP  
Sbjct: 787 TPFANEKTTSSSAE-PTEHAE--RTPLANENTTSSPAEPTENRERTANEKTTQFPAEPTE 843

Query: 478 EAVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVRQFLPPSRQSS 529
              ST  +  K  P  + P   R        ++    PT   +  P + + +
Sbjct: 844 NRESTANE--KTTPFPAEPTENREWTANENTTLSPAEPTEHEEMTPLANEKT 893



 Score = 31.6 bits (70), Expect = 2.8
 Identities = 36/169 (21%), Positives = 56/169 (33%), Gaps = 17/169 (10%)

Query: 353  PVSARKLKPTPPRPRSLHER--ILEEIKAERKLRPVSPEEIRRSRLDVTTPESTKNLVES 410
            P +  K  P+   P    ER  +  EI    +  P    E  R   +  TP   K     
Sbjct: 908  PFTNEKTTPSSAEPTEHGERTPLANEITTPSRAEPTEHGE--RIANEKATPSPAKPTEHG 965

Query: 411  SMVNGGLTSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHKSTSSSSVSPS 470
                   T+ +        ++ P   +    +PT    +S+E  E T ++ T+ S     
Sbjct: 966  ETTVNEDTTPSSAEPTENGERTPLANENTTTSPT----ESTEHGERTANEKTTPS----- 1016

Query: 471  FPEEPVLEAVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVR 519
             P EP      T     K +P  + P       P      E  TP+ V+
Sbjct: 1017 -PAEPTEHGERTPSANEKTIPSPAKPTEHEEMTPSAN---ENTTPSPVK 1061



 Score = 31.6 bits (70), Expect = 2.8
 Identities = 41/184 (22%), Positives = 66/184 (35%), Gaps = 26/184 (14%)

Query: 329  IPPRLKKSAHEIILDFIRSRPPLNPVSARKLKPTPPRPRSLHER---------ILEEIKA 379
            IP   K + HE           + P +     P+P +P    E+         +  E   
Sbjct: 1035 IPSPAKPTEHE----------EMTPSANENTTPSPVKPTEHGEKTTLANEKITLSPEGPT 1084

Query: 380  ERKLRPVSPEEIRRSRLDVTTPESTKNLVESSMVNGGLTSQTKENGLSTSQQV----PAQ 435
            E   +  S  E     L   T    +    +  +       T+    +TS  V    PA+
Sbjct: 1085 EHGAKTTSANEKITPSLAKPTEHGERTTSPNDKITSSAAESTEHRDRATSANVITPAPAE 1144

Query: 436  RKKLLRAPTLA-ELDSSESEEETLH--KSTSSSSVSPSFPEEPVLEAVSTRKKPPKFLPI 492
              K  +  TLA E  +  +E+ T H  K+TS++  +   PE+P L +  T     K  P+
Sbjct: 1145 PIKHAKRTTLAHEKMTQVTEKSTEHPEKTTSTTEKTTRTPEKPTLYSEKTICTKGKNTPV 1204

Query: 493  SSTP 496
               P
Sbjct: 1205 PEKP 1208


>gi|61966919 hypothetical protein LOC442444 [Homo sapiens]
          Length = 1035

 Score = 38.9 bits (89), Expect = 0.017
 Identities = 55/206 (26%), Positives = 80/206 (38%), Gaps = 25/206 (12%)

Query: 345 IRSRPPLNPVSARKLKPTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRLDVTTPEST 404
           +RS PP   VS   L+P  P+ R  H R          LRP  P + R S L +  PE+ 
Sbjct: 414 LRSEPPKIGVSHLCLEP--PKTRGSHLRPEPPETGVSHLRP-EPPKTRVSSLHLEPPETG 470

Query: 405 KNLV-----ESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEE--- 456
            + +     E  + +  L  +  + G+S     P + +     P  +E   S    E   
Sbjct: 471 VSHLCPEPPEKDVSH--LRPEPPDTGVSHLCPEPPKTRVSHLRPEPSETGVSHLRPEPPK 528

Query: 457 ----TLHKSTSSSSVSPSFPEEPVLEAVSTRKKPPKFLPISSTPQPERR-------QPPQ 505
               +LH++   SSVS   PE P       R +PPK    S  P+P          +PP+
Sbjct: 529 ILVSSLHQAPPESSVSHLRPEPPETGVSHLRPEPPKTRMYSLRPEPPDTGVSHLCPEPPK 588

Query: 506 RR-HSIEKETPTNVRQFLPPSRQSSR 530
            R  S+  E P      L P    +R
Sbjct: 589 TRVSSLPPEPPETGVSHLCPEPPETR 614



 Score = 38.1 bits (87), Expect = 0.030
 Identities = 53/205 (25%), Positives = 69/205 (33%), Gaps = 22/205 (10%)

Query: 345 IRSRPPLNP-VSARKLKPTPPRPRSLHERILEEIKAERKLRPVSPE--------EIRRSR 395
           + S PP  P      L P PP  R  H R          LRP  P+        E   + 
Sbjct: 591 VSSLPPEPPETGVSHLCPEPPETRVSHLRPEPPETGVSHLRPEPPKTRMYSLRPEPPNTG 650

Query: 396 LDVTTPESTKNLVESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEE 455
           +    PE  K  V S      L  +  E G+S     P + +     P   E   S    
Sbjct: 651 VSHLCPEPPKTRVSS------LPPEPPETGVSHLCPEPPETRVSHLRPEPPETGVSRLHP 704

Query: 456 E-------TLHKSTSSSSVSPSFPEEPVLEAVSTRKKPPKFLPISSTPQPERRQPPQRRH 508
           E       +LH     S VS   PE P       R +PPK    S  P+P   +    R 
Sbjct: 705 EPPKTRVSSLHAEPPESRVSHLCPEPPETGVSHLRPEPPKPRVSSLRPEPLETRVSHLRP 764

Query: 509 SIEKETPTNVRQFLPPSRQSSRSLE 533
              +   +++   LP  R SS  LE
Sbjct: 765 EPPETGVSHLHPELPKPRVSSLHLE 789



 Score = 37.7 bits (86), Expect = 0.039
 Identities = 56/204 (27%), Positives = 79/204 (38%), Gaps = 31/204 (15%)

Query: 349 PPLNPVSARKLKPTPPRPRSLH-----------ERILEEIKAE-RKLRPVSPEEIRRSRL 396
           PP   VS   L P PP+ R  H           +  LE  K+    LRP  P E   S L
Sbjct: 274 PPGTGVS--HLCPEPPKTRVSHLHREPPETGVPDLCLEPPKSRVSHLRP-EPSETGVSHL 330

Query: 397 DVTTPESTKNLVESSMVNGGLTSQTKENGLSTSQQVPAQRK--KLLRAPTLAEL-----D 449
               PE  K LV S      L  +  E G+S     P + +   L + P  A +     +
Sbjct: 331 H---PEPPKTLVSS------LHPEPPETGVSHLCPEPPETRVSPLRQLPPEAGVSHLCPE 381

Query: 450 SSESEEETLHKSTSSSSVSPSFPEEPVLEAVSTRKKPPKFLPISSTPQPERRQPPQRRHS 509
             ++    L   T  + VSP FPE P     + R +PPK        +P + +    R  
Sbjct: 382 PPKTRVPPLRPETPKNGVSPLFPEPPKTRISNLRSEPPKIGVSHLCLEPPKTRGSHLRPE 441

Query: 510 IEKETPTNVRQFLPPSRQSSRSLE 533
             +   +++R   P +R SS  LE
Sbjct: 442 PPETGVSHLRPEPPKTRVSSLHLE 465



 Score = 37.0 bits (84), Expect = 0.066
 Identities = 48/193 (24%), Positives = 69/193 (35%), Gaps = 23/193 (11%)

Query: 345 IRSRPPLNPVSARKLKPTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRLDVTTPEST 404
           +R  PP   VS   L P PP+ R  H R          LRP  P +I  S L    PES+
Sbjct: 486 LRPEPPDTGVS--HLCPEPPKTRVSHLRPEPSETGVSHLRP-EPPKILVSSLHQAPPESS 542

Query: 405 KNLVESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSS-------ESEEET 457
            +          L  +  E G+S  +  P + +     P   +   S       ++   +
Sbjct: 543 VS---------HLRPEPPETGVSHLRPEPPKTRMYSLRPEPPDTGVSHLCPEPPKTRVSS 593

Query: 458 LHKSTSSSSVSPSFPEEPVLEAVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTN 517
           L      + VS   PE P       R +PP+       P+P    P  R +S+  E P  
Sbjct: 594 LPPEPPETGVSHLCPEPPETRVSHLRPEPPETGVSHLRPEP----PKTRMYSLRPEPPNT 649

Query: 518 VRQFLPPSRQSSR 530
               L P    +R
Sbjct: 650 GVSHLCPEPPKTR 662



 Score = 33.5 bits (75), Expect = 0.73
 Identities = 45/163 (27%), Positives = 59/163 (36%), Gaps = 22/163 (13%)

Query: 345 IRSRPPLNP-VSARKLKPTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRLDVTTPES 403
           + S PP  P      L P PP  R  H R         +L P  P + R S L    PES
Sbjct: 663 VSSLPPEPPETGVSHLCPEPPETRVSHLRPEPPETGVSRLHP-EPPKTRVSSLHAEPPES 721

Query: 404 TKNLVESSMVNGGLTSQTKENGLSTSQ-QVPAQRKKLLRAPTLAELDSSESEEETLHKST 462
             +          L  +  E G+S  + + P  R   LR   L      E+    L    
Sbjct: 722 RVS---------HLCPEPPETGVSHLRPEPPKPRVSSLRPEPL------ETRVSHLRPEP 766

Query: 463 SSSSVSPSFPEEPVLEAVSTRKKPPKFLPISSTPQPERRQPPQ 505
             + VS   PE P     S   +PPK   +SS     R +PP+
Sbjct: 767 PETGVSHLHPELPKPRVSSLHLEPPKTRRVSSL----RLEPPK 805


>gi|239740773 PREDICTED: similar to diffuse panbronchiolitis
           critical region 1 [Homo sapiens]
          Length = 1400

 Score = 38.5 bits (88), Expect = 0.023
 Identities = 40/166 (24%), Positives = 61/166 (36%), Gaps = 10/166 (6%)

Query: 358 KLKPTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRLDVTTPESTKNLVESSMVNGGL 417
           K  P P  P    ER   E        P  P E    R  +   ++T +L E +  NG  
Sbjct: 794 KTTPFPAEPTENRERTANENTTPS---PAQPTE-NGDRTPLANEKTTPSLAEPTE-NGKR 848

Query: 418 TSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHKSTSSSSVSPSFPEEPVL 477
           T    E   S+S + P +  +  R P   E  +S   E T ++  +++  +  FP EP  
Sbjct: 849 TPFANEKTTSSSAE-PTEHAE--RTPLANENTTSSPAEPTENRERTANEKTTQFPAEPTE 905

Query: 478 EAVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVRQFLP 523
              ST  +  K  P  + P   R        ++    PT   +  P
Sbjct: 906 NRESTANE--KTTPFPAEPTENREWTANENTTLSPAEPTEHEEMTP 949


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 38.1 bits (87), Expect = 0.030
 Identities = 40/191 (20%), Positives = 71/191 (37%), Gaps = 11/191 (5%)

Query: 350 PLNPVSARKLKPTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRLDVTTPESTKNLVE 409
           P  P S    +PTP   +S      E      K  P +P+E   +      P + K    
Sbjct: 221 PKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAP 280

Query: 410 SSMVNGGLTS-----QTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHKSTSS 464
           ++      T+      T +    T+ + PA       APT  +  +  + +E    +   
Sbjct: 281 TTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEP 340

Query: 465 SSVSPS--FPEEPVLEAVSTRKKP----PKFLPISSTPQPERRQPPQRRHSIEKETPTNV 518
           +  +P    P  P   A +T K+P    PK    ++T +P    P +   +  K  PT  
Sbjct: 341 APTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTT 400

Query: 519 RQFLPPSRQSS 529
           ++  P + +S+
Sbjct: 401 KEPAPTTTKSA 411



 Score = 38.1 bits (87), Expect = 0.030
 Identities = 40/175 (22%), Positives = 67/175 (38%), Gaps = 16/175 (9%)

Query: 350 PLNPVSARKLKPTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRLDVTT---PESTKN 406
           P  P      +P P  P+      L+E        P +P++     L  TT   P ST +
Sbjct: 628 PKEPAPTTPKEPAPTTPKGTAPTTLKEPA------PTTPKKPAPKELAPTTTKGPTSTTS 681

Query: 407 LVESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEE--TLHKSTSS 464
              +          T +    T+ + PA        PT +E+ +  + +E  T+HKS   
Sbjct: 682 DKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDE 741

Query: 465 SSVSPSFPEEPVLEAVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVR 519
           S+  P    EP  +A+    K P    + +T  P   +P     + +K T  ++R
Sbjct: 742 ST--PELSAEPTPKALENSPKEP---GVPTTKTPAATKPEMTTTAKDKTTERDLR 791



 Score = 37.0 bits (84), Expect = 0.066
 Identities = 42/181 (23%), Positives = 68/181 (37%), Gaps = 22/181 (12%)

Query: 350 PLNPVSARKLKPTPPRPRSLHERILEEIK--AERKLRPVSPEEIRRSRLDVTTPESTKNL 407
           P  P      KP P  P+       +E      +K  P +P+E   +    T P + K L
Sbjct: 431 PKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKL 490

Query: 408 VESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHKSTSSSSV 467
                     T  T E    T+ + PA       APT  E  +  + EE     T+  + 
Sbjct: 491 ----------TPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPA--PTTPKAA 538

Query: 468 SPSFPEEPVLE-----AVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVRQFL 522
           +P+ P+EP        A +T K+P    P  + P   +   P    ++++  PT  ++  
Sbjct: 539 APNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPT---TLKEPAPTTPKKPA 595

Query: 523 P 523
           P
Sbjct: 596 P 596



 Score = 37.0 bits (84), Expect = 0.066
 Identities = 38/173 (21%), Positives = 66/173 (38%), Gaps = 10/173 (5%)

Query: 353 PVSARKLKPTPPR---PRSLHERILEEIK--AERKLRPVSPEEIRRSRLDVTTPESTKNL 407
           P + ++  PT P+   P +L E      K  A ++L P + +E   +  D   P + K  
Sbjct: 564 PTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGT 623

Query: 408 VESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHKSTSSSSV 467
             ++      T+  +    +     P   K+   APT  +  + +    T  K  +S++ 
Sbjct: 624 APTTPKEPAPTTPKEPAPTTPKGTAPTTLKE--PAPTTPKKPAPKELAPTTTKGPTSTTS 681

Query: 468 SPSFPEEPVLEAVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVRQ 520
               P  P   A +T K+P    P    P      PP    + E  TPT  ++
Sbjct: 682 DKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPT---TSEVSTPTTTKE 731



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 50/220 (22%), Positives = 77/220 (35%), Gaps = 25/220 (11%)

Query: 350 PLNPVSARKLKPTPPRPRSLHERILEEIK---------AERKLRPVSPEEIRRSRLDVTT 400
           P  P      +PTP  P+       E            A +K  P +P+E   +      
Sbjct: 314 PKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPA 373

Query: 401 PESTKNLVESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHK 460
           P +TK    ++      T+ TK    +T +  P   K     P      +++    T  K
Sbjct: 374 PTTTKEPSPTTPKEPAPTT-TKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPK 432

Query: 461 S---TSSSSVSPSFPEEPVLE-----AVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEK 512
               T+    +P+ P+EP        A +T KKP    P    P   +   P    + +K
Sbjct: 433 EPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPT---TPKK 489

Query: 513 ETPTNVRQFLP--PSRQSSRSLEEFC--YPVECLALTVEE 548
            TPT   +  P  P + +  + EE     P E    T EE
Sbjct: 490 LTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEE 529


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 38.1 bits (87), Expect = 0.030
 Identities = 40/191 (20%), Positives = 71/191 (37%), Gaps = 11/191 (5%)

Query: 350 PLNPVSARKLKPTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRLDVTTPESTKNLVE 409
           P  P S    +PTP   +S      E      K  P +P+E   +      P + K    
Sbjct: 262 PKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAP 321

Query: 410 SSMVNGGLTS-----QTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHKSTSS 464
           ++      T+      T +    T+ + PA       APT  +  +  + +E    +   
Sbjct: 322 TTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEP 381

Query: 465 SSVSPS--FPEEPVLEAVSTRKKP----PKFLPISSTPQPERRQPPQRRHSIEKETPTNV 518
           +  +P    P  P   A +T K+P    PK    ++T +P    P +   +  K  PT  
Sbjct: 382 APTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTT 441

Query: 519 RQFLPPSRQSS 529
           ++  P + +S+
Sbjct: 442 KEPAPTTTKSA 452



 Score = 38.1 bits (87), Expect = 0.030
 Identities = 40/175 (22%), Positives = 67/175 (38%), Gaps = 16/175 (9%)

Query: 350 PLNPVSARKLKPTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRLDVTT---PESTKN 406
           P  P      +P P  P+      L+E        P +P++     L  TT   P ST +
Sbjct: 669 PKEPAPTTPKEPAPTTPKGTAPTTLKEPA------PTTPKKPAPKELAPTTTKGPTSTTS 722

Query: 407 LVESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEE--TLHKSTSS 464
              +          T +    T+ + PA        PT +E+ +  + +E  T+HKS   
Sbjct: 723 DKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDE 782

Query: 465 SSVSPSFPEEPVLEAVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVR 519
           S+  P    EP  +A+    K P    + +T  P   +P     + +K T  ++R
Sbjct: 783 ST--PELSAEPTPKALENSPKEP---GVPTTKTPAATKPEMTTTAKDKTTERDLR 832



 Score = 37.0 bits (84), Expect = 0.066
 Identities = 42/181 (23%), Positives = 68/181 (37%), Gaps = 22/181 (12%)

Query: 350 PLNPVSARKLKPTPPRPRSLHERILEEIK--AERKLRPVSPEEIRRSRLDVTTPESTKNL 407
           P  P      KP P  P+       +E      +K  P +P+E   +    T P + K L
Sbjct: 472 PKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKL 531

Query: 408 VESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHKSTSSSSV 467
                     T  T E    T+ + PA       APT  E  +  + EE     T+  + 
Sbjct: 532 ----------TPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPA--PTTPKAA 579

Query: 468 SPSFPEEPVLE-----AVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVRQFL 522
           +P+ P+EP        A +T K+P    P  + P   +   P    ++++  PT  ++  
Sbjct: 580 APNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPT---TLKEPAPTTPKKPA 636

Query: 523 P 523
           P
Sbjct: 637 P 637



 Score = 37.0 bits (84), Expect = 0.066
 Identities = 38/173 (21%), Positives = 66/173 (38%), Gaps = 10/173 (5%)

Query: 353 PVSARKLKPTPPR---PRSLHERILEEIK--AERKLRPVSPEEIRRSRLDVTTPESTKNL 407
           P + ++  PT P+   P +L E      K  A ++L P + +E   +  D   P + K  
Sbjct: 605 PTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGT 664

Query: 408 VESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHKSTSSSSV 467
             ++      T+  +    +     P   K+   APT  +  + +    T  K  +S++ 
Sbjct: 665 APTTPKEPAPTTPKEPAPTTPKGTAPTTLKE--PAPTTPKKPAPKELAPTTTKGPTSTTS 722

Query: 468 SPSFPEEPVLEAVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVRQ 520
               P  P   A +T K+P    P    P      PP    + E  TPT  ++
Sbjct: 723 DKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPT---TSEVSTPTTTKE 772



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 50/220 (22%), Positives = 77/220 (35%), Gaps = 25/220 (11%)

Query: 350 PLNPVSARKLKPTPPRPRSLHERILEEIK---------AERKLRPVSPEEIRRSRLDVTT 400
           P  P      +PTP  P+       E            A +K  P +P+E   +      
Sbjct: 355 PKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPA 414

Query: 401 PESTKNLVESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHK 460
           P +TK    ++      T+ TK    +T +  P   K     P      +++    T  K
Sbjct: 415 PTTTKEPSPTTPKEPAPTT-TKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPK 473

Query: 461 S---TSSSSVSPSFPEEPVLE-----AVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEK 512
               T+    +P+ P+EP        A +T KKP    P    P   +   P    + +K
Sbjct: 474 EPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPT---TPKK 530

Query: 513 ETPTNVRQFLP--PSRQSSRSLEEFC--YPVECLALTVEE 548
            TPT   +  P  P + +  + EE     P E    T EE
Sbjct: 531 LTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEE 570


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 38.1 bits (87), Expect = 0.030
 Identities = 40/191 (20%), Positives = 71/191 (37%), Gaps = 11/191 (5%)

Query: 350 PLNPVSARKLKPTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRLDVTTPESTKNLVE 409
           P  P S    +PTP   +S      E      K  P +P+E   +      P + K    
Sbjct: 314 PKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAP 373

Query: 410 SSMVNGGLTS-----QTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHKSTSS 464
           ++      T+      T +    T+ + PA       APT  +  +  + +E    +   
Sbjct: 374 TTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEP 433

Query: 465 SSVSPS--FPEEPVLEAVSTRKKP----PKFLPISSTPQPERRQPPQRRHSIEKETPTNV 518
           +  +P    P  P   A +T K+P    PK    ++T +P    P +   +  K  PT  
Sbjct: 434 APTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTT 493

Query: 519 RQFLPPSRQSS 529
           ++  P + +S+
Sbjct: 494 KEPAPTTTKSA 504



 Score = 38.1 bits (87), Expect = 0.030
 Identities = 40/175 (22%), Positives = 67/175 (38%), Gaps = 16/175 (9%)

Query: 350 PLNPVSARKLKPTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRLDVTT---PESTKN 406
           P  P      +P P  P+      L+E        P +P++     L  TT   P ST +
Sbjct: 721 PKEPAPTTPKEPAPTTPKGTAPTTLKEPA------PTTPKKPAPKELAPTTTKGPTSTTS 774

Query: 407 LVESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEE--TLHKSTSS 464
              +          T +    T+ + PA        PT +E+ +  + +E  T+HKS   
Sbjct: 775 DKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDE 834

Query: 465 SSVSPSFPEEPVLEAVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVR 519
           S+  P    EP  +A+    K P    + +T  P   +P     + +K T  ++R
Sbjct: 835 ST--PELSAEPTPKALENSPKEP---GVPTTKTPAATKPEMTTTAKDKTTERDLR 884



 Score = 37.0 bits (84), Expect = 0.066
 Identities = 42/181 (23%), Positives = 68/181 (37%), Gaps = 22/181 (12%)

Query: 350 PLNPVSARKLKPTPPRPRSLHERILEEIK--AERKLRPVSPEEIRRSRLDVTTPESTKNL 407
           P  P      KP P  P+       +E      +K  P +P+E   +    T P + K L
Sbjct: 524 PKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKL 583

Query: 408 VESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHKSTSSSSV 467
                     T  T E    T+ + PA       APT  E  +  + EE     T+  + 
Sbjct: 584 ----------TPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPA--PTTPKAA 631

Query: 468 SPSFPEEPVLE-----AVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVRQFL 522
           +P+ P+EP        A +T K+P    P  + P   +   P    ++++  PT  ++  
Sbjct: 632 APNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPT---TLKEPAPTTPKKPA 688

Query: 523 P 523
           P
Sbjct: 689 P 689



 Score = 37.0 bits (84), Expect = 0.066
 Identities = 38/173 (21%), Positives = 66/173 (38%), Gaps = 10/173 (5%)

Query: 353 PVSARKLKPTPPR---PRSLHERILEEIK--AERKLRPVSPEEIRRSRLDVTTPESTKNL 407
           P + ++  PT P+   P +L E      K  A ++L P + +E   +  D   P + K  
Sbjct: 657 PTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGT 716

Query: 408 VESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHKSTSSSSV 467
             ++      T+  +    +     P   K+   APT  +  + +    T  K  +S++ 
Sbjct: 717 APTTPKEPAPTTPKEPAPTTPKGTAPTTLKE--PAPTTPKKPAPKELAPTTTKGPTSTTS 774

Query: 468 SPSFPEEPVLEAVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVRQ 520
               P  P   A +T K+P    P    P      PP    + E  TPT  ++
Sbjct: 775 DKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPT---TSEVSTPTTTKE 824



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 50/220 (22%), Positives = 77/220 (35%), Gaps = 25/220 (11%)

Query: 350 PLNPVSARKLKPTPPRPRSLHERILEEIK---------AERKLRPVSPEEIRRSRLDVTT 400
           P  P      +PTP  P+       E            A +K  P +P+E   +      
Sbjct: 407 PKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPA 466

Query: 401 PESTKNLVESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHK 460
           P +TK    ++      T+ TK    +T +  P   K     P      +++    T  K
Sbjct: 467 PTTTKEPSPTTPKEPAPTT-TKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPK 525

Query: 461 S---TSSSSVSPSFPEEPVLE-----AVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEK 512
               T+    +P+ P+EP        A +T KKP    P    P   +   P    + +K
Sbjct: 526 EPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPT---TPKK 582

Query: 513 ETPTNVRQFLP--PSRQSSRSLEEFC--YPVECLALTVEE 548
            TPT   +  P  P + +  + EE     P E    T EE
Sbjct: 583 LTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEE 622


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 38.1 bits (87), Expect = 0.030
 Identities = 40/191 (20%), Positives = 71/191 (37%), Gaps = 11/191 (5%)

Query: 350 PLNPVSARKLKPTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRLDVTTPESTKNLVE 409
           P  P S    +PTP   +S      E      K  P +P+E   +      P + K    
Sbjct: 355 PKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAP 414

Query: 410 SSMVNGGLTS-----QTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHKSTSS 464
           ++      T+      T +    T+ + PA       APT  +  +  + +E    +   
Sbjct: 415 TTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEP 474

Query: 465 SSVSPS--FPEEPVLEAVSTRKKP----PKFLPISSTPQPERRQPPQRRHSIEKETPTNV 518
           +  +P    P  P   A +T K+P    PK    ++T +P    P +   +  K  PT  
Sbjct: 475 APTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTT 534

Query: 519 RQFLPPSRQSS 529
           ++  P + +S+
Sbjct: 535 KEPAPTTTKSA 545



 Score = 38.1 bits (87), Expect = 0.030
 Identities = 40/175 (22%), Positives = 67/175 (38%), Gaps = 16/175 (9%)

Query: 350 PLNPVSARKLKPTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRLDVTT---PESTKN 406
           P  P      +P P  P+      L+E        P +P++     L  TT   P ST +
Sbjct: 762 PKEPAPTTPKEPAPTTPKGTAPTTLKEPA------PTTPKKPAPKELAPTTTKGPTSTTS 815

Query: 407 LVESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEE--TLHKSTSS 464
              +          T +    T+ + PA        PT +E+ +  + +E  T+HKS   
Sbjct: 816 DKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDE 875

Query: 465 SSVSPSFPEEPVLEAVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVR 519
           S+  P    EP  +A+    K P    + +T  P   +P     + +K T  ++R
Sbjct: 876 ST--PELSAEPTPKALENSPKEP---GVPTTKTPAATKPEMTTTAKDKTTERDLR 925



 Score = 37.0 bits (84), Expect = 0.066
 Identities = 42/181 (23%), Positives = 68/181 (37%), Gaps = 22/181 (12%)

Query: 350 PLNPVSARKLKPTPPRPRSLHERILEEIK--AERKLRPVSPEEIRRSRLDVTTPESTKNL 407
           P  P      KP P  P+       +E      +K  P +P+E   +    T P + K L
Sbjct: 565 PKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKL 624

Query: 408 VESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHKSTSSSSV 467
                     T  T E    T+ + PA       APT  E  +  + EE     T+  + 
Sbjct: 625 ----------TPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPA--PTTPKAA 672

Query: 468 SPSFPEEPVLE-----AVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVRQFL 522
           +P+ P+EP        A +T K+P    P  + P   +   P    ++++  PT  ++  
Sbjct: 673 APNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPT---TLKEPAPTTPKKPA 729

Query: 523 P 523
           P
Sbjct: 730 P 730



 Score = 37.0 bits (84), Expect = 0.066
 Identities = 38/173 (21%), Positives = 66/173 (38%), Gaps = 10/173 (5%)

Query: 353 PVSARKLKPTPPR---PRSLHERILEEIK--AERKLRPVSPEEIRRSRLDVTTPESTKNL 407
           P + ++  PT P+   P +L E      K  A ++L P + +E   +  D   P + K  
Sbjct: 698 PTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGT 757

Query: 408 VESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHKSTSSSSV 467
             ++      T+  +    +     P   K+   APT  +  + +    T  K  +S++ 
Sbjct: 758 APTTPKEPAPTTPKEPAPTTPKGTAPTTLKE--PAPTTPKKPAPKELAPTTTKGPTSTTS 815

Query: 468 SPSFPEEPVLEAVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVRQ 520
               P  P   A +T K+P    P    P      PP    + E  TPT  ++
Sbjct: 816 DKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPT---TSEVSTPTTTKE 865



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 50/220 (22%), Positives = 77/220 (35%), Gaps = 25/220 (11%)

Query: 350 PLNPVSARKLKPTPPRPRSLHERILEEIK---------AERKLRPVSPEEIRRSRLDVTT 400
           P  P      +PTP  P+       E            A +K  P +P+E   +      
Sbjct: 448 PKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPA 507

Query: 401 PESTKNLVESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHK 460
           P +TK    ++      T+ TK    +T +  P   K     P      +++    T  K
Sbjct: 508 PTTTKEPSPTTPKEPAPTT-TKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPK 566

Query: 461 S---TSSSSVSPSFPEEPVLE-----AVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEK 512
               T+    +P+ P+EP        A +T KKP    P    P   +   P    + +K
Sbjct: 567 EPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPT---TPKK 623

Query: 513 ETPTNVRQFLP--PSRQSSRSLEEFC--YPVECLALTVEE 548
            TPT   +  P  P + +  + EE     P E    T EE
Sbjct: 624 LTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEE 663


>gi|57222568 myeloid/lymphoid or mixed-lineage leukemia (trithorax
           homolog, Drosophila); translocated to, 6 [Homo sapiens]
          Length = 1093

 Score = 37.7 bits (86), Expect = 0.039
 Identities = 40/147 (27%), Positives = 59/147 (40%), Gaps = 18/147 (12%)

Query: 375 EEIKAERKLRPVSPEEIRRSRLDVTTPESTKNLVESSMVNGGLTSQTKENGL------ST 428
           E +K + K RP SP  I    + V T +   +   SS  +   T +T E+        S+
Sbjct: 246 ERLKQKHKKRPESPPSILTPPV-VPTADKVSSSASSSSHHEASTQETSESSRESKGKKSS 304

Query: 429 SQQVPAQRKKLLRAPTLAELDSSESEEETLHKST--------SSSSVSPSFPEEPVLEAV 480
           S  +  + KKL     ++   S+ S   +   S+        SS   SP F   P LE  
Sbjct: 305 SHSLSHKGKKLSSGKGVSSFTSASSSSSSSSSSSGGPFQPAVSSLQSSPDFSAFPKLEQP 364

Query: 481 STRK--KPPKFLPISSTPQPERRQPPQ 505
              K  KP    P S+ P P   +PP+
Sbjct: 365 EEDKYSKPTAPAP-SAPPSPSAPEPPK 390


>gi|24497609 nucleoporin 62kDa [Homo sapiens]
          Length = 522

 Score = 37.4 bits (85), Expect = 0.051
 Identities = 55/226 (24%), Positives = 92/226 (40%), Gaps = 50/226 (22%)

Query: 8   AGGGEPRTEAVGGEGPREPGAAGGAAGGSRDALSLEEILRLYNQPINEEQAWAVCYQCCG 67
           A  G P   A     P  PGAA GAA  S  A++  ++  L N+       W++      
Sbjct: 298 APAGIPSNTAAAVTAPPGPGAAAGAAASS--AMTYAQLESLINK-------WSL------ 342

Query: 68  SLRAAARRRQPRHRVRSAAQIRVWRDGAVTLAPAADDAGEPPPVAGKLGYSQCMETEVIE 127
                    Q RH ++ A Q+  W    +                G+   S   E E ++
Sbjct: 343 -----ELEDQERHFLQQATQVNAWDRTLIE--------------NGEKITSLHREVEKVK 383

Query: 128 SLGIIIYKALDYGLKENEERE-LSPPLEQLIDHMANTV---EADGSNDEGYEAAEEGLGD 183
                + + LD+ L + +E E L  PLE+L+   + T+    AD   ++ Y+ AE    +
Sbjct: 384 LDQKRLDQELDFILSQQKELEDLLSPLEELVKEQSGTIYLQHADEEREKTYKLAE----N 439

Query: 184 EDEKRKISAIRSYRDVMKLCAAHLPTE---SDAPNHYQAVCRALFA 226
            D + K  A +  +D+++    HL T    +D  +  Q +C+ L A
Sbjct: 440 IDAQLKRMA-QDLKDIIE----HLNTSGAPADTSDPLQQICKILNA 480


>gi|24497607 nucleoporin 62kDa [Homo sapiens]
          Length = 522

 Score = 37.4 bits (85), Expect = 0.051
 Identities = 55/226 (24%), Positives = 92/226 (40%), Gaps = 50/226 (22%)

Query: 8   AGGGEPRTEAVGGEGPREPGAAGGAAGGSRDALSLEEILRLYNQPINEEQAWAVCYQCCG 67
           A  G P   A     P  PGAA GAA  S  A++  ++  L N+       W++      
Sbjct: 298 APAGIPSNTAAAVTAPPGPGAAAGAAASS--AMTYAQLESLINK-------WSL------ 342

Query: 68  SLRAAARRRQPRHRVRSAAQIRVWRDGAVTLAPAADDAGEPPPVAGKLGYSQCMETEVIE 127
                    Q RH ++ A Q+  W    +                G+   S   E E ++
Sbjct: 343 -----ELEDQERHFLQQATQVNAWDRTLIE--------------NGEKITSLHREVEKVK 383

Query: 128 SLGIIIYKALDYGLKENEERE-LSPPLEQLIDHMANTV---EADGSNDEGYEAAEEGLGD 183
                + + LD+ L + +E E L  PLE+L+   + T+    AD   ++ Y+ AE    +
Sbjct: 384 LDQKRLDQELDFILSQQKELEDLLSPLEELVKEQSGTIYLQHADEEREKTYKLAE----N 439

Query: 184 EDEKRKISAIRSYRDVMKLCAAHLPTE---SDAPNHYQAVCRALFA 226
            D + K  A +  +D+++    HL T    +D  +  Q +C+ L A
Sbjct: 440 IDAQLKRMA-QDLKDIIE----HLNTSGAPADTSDPLQQICKILNA 480


>gi|24497605 nucleoporin 62kDa [Homo sapiens]
          Length = 522

 Score = 37.4 bits (85), Expect = 0.051
 Identities = 55/226 (24%), Positives = 92/226 (40%), Gaps = 50/226 (22%)

Query: 8   AGGGEPRTEAVGGEGPREPGAAGGAAGGSRDALSLEEILRLYNQPINEEQAWAVCYQCCG 67
           A  G P   A     P  PGAA GAA  S  A++  ++  L N+       W++      
Sbjct: 298 APAGIPSNTAAAVTAPPGPGAAAGAAASS--AMTYAQLESLINK-------WSL------ 342

Query: 68  SLRAAARRRQPRHRVRSAAQIRVWRDGAVTLAPAADDAGEPPPVAGKLGYSQCMETEVIE 127
                    Q RH ++ A Q+  W    +                G+   S   E E ++
Sbjct: 343 -----ELEDQERHFLQQATQVNAWDRTLIE--------------NGEKITSLHREVEKVK 383

Query: 128 SLGIIIYKALDYGLKENEERE-LSPPLEQLIDHMANTV---EADGSNDEGYEAAEEGLGD 183
                + + LD+ L + +E E L  PLE+L+   + T+    AD   ++ Y+ AE    +
Sbjct: 384 LDQKRLDQELDFILSQQKELEDLLSPLEELVKEQSGTIYLQHADEEREKTYKLAE----N 439

Query: 184 EDEKRKISAIRSYRDVMKLCAAHLPTE---SDAPNHYQAVCRALFA 226
            D + K  A +  +D+++    HL T    +D  +  Q +C+ L A
Sbjct: 440 IDAQLKRMA-QDLKDIIE----HLNTSGAPADTSDPLQQICKILNA 480


>gi|24497603 nucleoporin 62kDa [Homo sapiens]
          Length = 522

 Score = 37.4 bits (85), Expect = 0.051
 Identities = 55/226 (24%), Positives = 92/226 (40%), Gaps = 50/226 (22%)

Query: 8   AGGGEPRTEAVGGEGPREPGAAGGAAGGSRDALSLEEILRLYNQPINEEQAWAVCYQCCG 67
           A  G P   A     P  PGAA GAA  S  A++  ++  L N+       W++      
Sbjct: 298 APAGIPSNTAAAVTAPPGPGAAAGAAASS--AMTYAQLESLINK-------WSL------ 342

Query: 68  SLRAAARRRQPRHRVRSAAQIRVWRDGAVTLAPAADDAGEPPPVAGKLGYSQCMETEVIE 127
                    Q RH ++ A Q+  W    +                G+   S   E E ++
Sbjct: 343 -----ELEDQERHFLQQATQVNAWDRTLIE--------------NGEKITSLHREVEKVK 383

Query: 128 SLGIIIYKALDYGLKENEERE-LSPPLEQLIDHMANTV---EADGSNDEGYEAAEEGLGD 183
                + + LD+ L + +E E L  PLE+L+   + T+    AD   ++ Y+ AE    +
Sbjct: 384 LDQKRLDQELDFILSQQKELEDLLSPLEELVKEQSGTIYLQHADEEREKTYKLAE----N 439

Query: 184 EDEKRKISAIRSYRDVMKLCAAHLPTE---SDAPNHYQAVCRALFA 226
            D + K  A +  +D+++    HL T    +D  +  Q +C+ L A
Sbjct: 440 IDAQLKRMA-QDLKDIIE----HLNTSGAPADTSDPLQQICKILNA 480


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score = 37.0 bits (84), Expect = 0.066
 Identities = 40/191 (20%), Positives = 79/191 (41%), Gaps = 30/191 (15%)

Query: 360  KPTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRLDVTTPESTKNLVESSMVNGGLTS 419
            K  PP P+ + + ++E+I  E+  R +  E+++ +++    PE +K +V        +  
Sbjct: 9172 KKAPPPPKVIKKPVIEKI--EKTSRRMEEEKVQVTKV----PEVSKKIVPQKPSRTPVQE 9225

Query: 420  QT---KENGLSTSQQVPAQRKKLLRAPTLAELDSSESE-------EETLH----KSTSSS 465
            +    K   + T + V ++ K    + T  E+  +  E       EE +H    K     
Sbjct: 9226 EVIEVKVPAVHTKKMVISEEKMFFASHTEEEVSVTVPEVQKEIVTEEKIHVAISKRVEPP 9285

Query: 466  SVSPSFPEEPVLEAVSTRKKP-------PKFLPISSTPQPERRQP---PQRRHSIEKETP 515
               P  PE+P  E V+    P       PK   +   P PE ++P   P++  +   + P
Sbjct: 9286 PKVPELPEKPAPEEVAPVPIPKKVEPPAPKVPEVPKKPVPEEKKPVPVPKKEPAAPPKVP 9345

Query: 516  TNVRQFLPPSR 526
               ++ +P  +
Sbjct: 9346 EVPKKPVPEEK 9356



 Score = 32.0 bits (71), Expect = 2.1
 Identities = 42/206 (20%), Positives = 79/206 (38%), Gaps = 40/206 (19%)

Query: 353  PVSARKLKPTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRLDVTTPESTKNLVESSM 412
            PV     +P P +P++   ++L++   E K+    P++++     V  PE  K + E   
Sbjct: 9794 PVKPVPEEPVPTKPKAPPAKVLKKAVPEEKVPVPIPKKLKPPPPKV--PEEPKKVFEEK- 9850

Query: 413  VNGGLTSQTKENGLSTSQQVPAQRKKL----------------LRAPTL-AELDSS---- 451
            +   +T + KE     + +VP + K++                +R P +  EL+      
Sbjct: 9851 IRISITKREKEQVTEPAAKVPMKPKRVVAEEKVPVPRKEVAPPVRVPEVPKELEPEEVAF 9910

Query: 452  -------------ESEEETLHKSTSSSSVSPSFPEEPVLEAVSTRKKPPKFLPISSTPQP 498
                         E EEE +H+     +     P  PV      RK  P+       P P
Sbjct: 9911 EEEVVTHVEEYLVEEEEEYIHEEEEFITEEEVVPVIPVKVPEVPRKPVPE--EKKPVPVP 9968

Query: 499  ERRQ-PPQRRHSIEKETPTNVRQFLP 523
            ++++ PP +   + K+    V   +P
Sbjct: 9969 KKKEAPPAKVPEVPKKPEEKVPVLIP 9994


>gi|38569480 megakaryoblastic leukemia 2 protein [Homo sapiens]
          Length = 1049

 Score = 37.0 bits (84), Expect = 0.066
 Identities = 53/227 (23%), Positives = 94/227 (41%), Gaps = 23/227 (10%)

Query: 313 IRCKRYTLRKVMVNGDIPPRLKKSA--HEIILDFIRSRPPLNPVSARKLKPTPPRPRSLH 370
           +R ++   R+ +V+  I P LK  A  HE I    R+R         K++  P R   + 
Sbjct: 55  LRLQQRRTREQLVDQGIMPPLKSPAAFHEQIKSLERART--ENFLKHKIRSRPDRSELVR 112

Query: 371 ERILEEIKAERKLRPVSPEEIRRSRL------DVTTPESTKNLVESSMVNGGLTSQTKEN 424
             ILEE  AE  L+  +  +++R+RL       +        LVE +++   + S  KE 
Sbjct: 113 MHILEETFAEPSLQ-ATQMKLKRARLADDLNEKIAQRPGPMELVEKNILP--VDSSVKEA 169

Query: 425 GLSTSQQVPAQRKKLLRAPTLAELDSSE--SEEETLHKSTSSSSVSPSFPEEPVLEAVST 482
            +   ++     +         + DSS+  S ++   + +  S+ SPS P+     +  T
Sbjct: 170 IIGVGKEDYPHTQ----GDFSFDEDSSDALSPDQPASQESQGSAASPSEPKVSESPSPVT 225

Query: 483 RKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVRQFLPPSRQSS 529
              P +F  +S T     + PP    + ++  P      LP +  SS
Sbjct: 226 TNTPAQFASVSPTVPEFLKTPP----TADQPPPRPAAPVLPTNTVSS 268



 Score = 30.8 bits (68), Expect = 4.8
 Identities = 42/184 (22%), Positives = 71/184 (38%), Gaps = 25/184 (13%)

Query: 353 PVSARKLKPTP-----PRPRSLHERILEEIKAERKLRPVSPEEIRRSRLDVTTPESTKNL 407
           P + R+   TP     P P SL +  + E+K E KLR +     +   ++   P    N 
Sbjct: 379 PNTPRQNTSTPVRKPGPLPSSLDDLKVSELKTELKLRGLPVSGTKPDLIERLKPYQEVN- 437

Query: 408 VESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHKSTSSSSV 467
             S +  GG+ +      +S+S  V +  +  +  P             TLH +T +SSV
Sbjct: 438 -SSGLAAGGIVA------VSSSAIVTSNPEVTVALPV-----------TTLH-NTVTSSV 478

Query: 468 SPSFPEEPVLEAVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVRQFLPPSRQ 527
           S    E P     +  +      P+  +P P  +       +   +T T +   + PS+ 
Sbjct: 479 STLKAELPPTGTSNATRVENVHSPLPISPSPSEQSSLSTDDTNMADTFTEIMTMMSPSQF 538

Query: 528 SSRS 531
            S S
Sbjct: 539 LSSS 542


>gi|114431248 hypothetical protein LOC205717 [Homo sapiens]
          Length = 2245

 Score = 36.6 bits (83), Expect = 0.087
 Identities = 28/91 (30%), Positives = 44/91 (48%), Gaps = 7/91 (7%)

Query: 391 IRRSRLDVTTPESTKNLVESSMVNGGLTS------QTKENGLSTSQQVPAQRKKLLRAPT 444
           +++   +V   + T NLV    ++G   S      QT    L+T+Q VP      + A +
Sbjct: 176 LQKQTANVVPVQRTCNLVTPVSISGVYPSENKPWHQTTVPALATNQPVPLCLPAAISAQS 235

Query: 445 LAELDSSESEEETLHKSTSSSSVSPSFPEEP 475
           + EL +SESE   L  +TS S ++ S   EP
Sbjct: 236 ILELPTSESESNVL-GATSGSLIAVSIESEP 265


>gi|239751395 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 306

 Score = 36.6 bits (83), Expect = 0.087
 Identities = 45/178 (25%), Positives = 59/178 (33%), Gaps = 8/178 (4%)

Query: 347 SRPPLNPVSARKLKPTPPRPRSLHERILEEIKAERK------LRPVSPEEIRRSRLDVTT 400
           S P L P S   L P P   RS    +               L P +   +  S     T
Sbjct: 70  STPTLTPSSTPTLTPQPILTRSSTPTLTPSSPPTLTPSNTPTLTPSNTPTLTPSNTPTLT 129

Query: 401 PESTKNLVESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRA--PTLAELDSSESEEETL 458
           P ST  L  SS      +S+      ST    P+ R  L R+  PTL    +      + 
Sbjct: 130 PSSTPTLTPSSTPTLTPSSRPILTRSSTPTLTPSSRPILTRSSTPTLTPSSTPTLTPSST 189

Query: 459 HKSTSSSSVSPSFPEEPVLEAVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPT 516
              T SS+ + +    P+L   ST    P   PI +        P  R       TPT
Sbjct: 190 PTLTPSSTPTLTPSSRPILTRSSTPTLTPSSRPILTPSSTPTLTPSSRPILTRSSTPT 247



 Score = 32.3 bits (72), Expect = 1.6
 Identities = 48/200 (24%), Positives = 65/200 (32%), Gaps = 16/200 (8%)

Query: 349 PPLNPVSARKLKPTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRLDVTTPESTKNLV 408
           P L P S   L P+     +   + +    +   L P SP  +  S     TP +T  L 
Sbjct: 8   PTLTPSSPPTLTPSSTPTLTPSSQPILTRSSTPTLTPSSPPTLTPSNTPTLTPSNTPTLT 67

Query: 409 ESSMVN------GGLTSQTKENGLSTSQQVPAQRKKLL--RAPTLAELDS---SESEEET 457
            SS           LT Q      ST    P+    L     PTL   ++   + S   T
Sbjct: 68  PSSTPTLTPSSTPTLTPQPILTRSSTPTLTPSSPPTLTPSNTPTLTPSNTPTLTPSNTPT 127

Query: 458 LHKSTSSSSVSPSFP-----EEPVLEAVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEK 512
           L  S++ +    S P       P+L   ST    P   PI +        P         
Sbjct: 128 LTPSSTPTLTPSSTPTLTPSSRPILTRSSTPTLTPSSRPILTRSSTPTLTPSSTPTLTPS 187

Query: 513 ETPTNVRQFLPPSRQSSRSL 532
            TPT      P    SSR +
Sbjct: 188 STPTLTPSSTPTLTPSSRPI 207


>gi|239745904 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 306

 Score = 36.6 bits (83), Expect = 0.087
 Identities = 45/178 (25%), Positives = 59/178 (33%), Gaps = 8/178 (4%)

Query: 347 SRPPLNPVSARKLKPTPPRPRSLHERILEEIKAERK------LRPVSPEEIRRSRLDVTT 400
           S P L P S   L P P   RS    +               L P +   +  S     T
Sbjct: 70  STPTLTPSSTPTLTPQPILTRSSTPTLTPSSPPTLTPSNTPTLTPSNTPTLTPSNTPTLT 129

Query: 401 PESTKNLVESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRA--PTLAELDSSESEEETL 458
           P ST  L  SS      +S+      ST    P+ R  L R+  PTL    +      + 
Sbjct: 130 PSSTPTLTPSSTPTLTPSSRPILTRSSTPTLTPSSRPILTRSSTPTLTPSSTPTLTPSST 189

Query: 459 HKSTSSSSVSPSFPEEPVLEAVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPT 516
              T SS+ + +    P+L   ST    P   PI +        P  R       TPT
Sbjct: 190 PTLTPSSTPTLTPSSRPILTRSSTPTLTPSSRPILTPSSTPTLTPSSRPILTRSSTPT 247



 Score = 32.3 bits (72), Expect = 1.6
 Identities = 48/200 (24%), Positives = 65/200 (32%), Gaps = 16/200 (8%)

Query: 349 PPLNPVSARKLKPTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRLDVTTPESTKNLV 408
           P L P S   L P+     +   + +    +   L P SP  +  S     TP +T  L 
Sbjct: 8   PTLTPSSPPTLTPSSTPTLTPSSQPILTRSSTPTLTPSSPPTLTPSNTPTLTPSNTPTLT 67

Query: 409 ESSMVN------GGLTSQTKENGLSTSQQVPAQRKKLL--RAPTLAELDS---SESEEET 457
            SS           LT Q      ST    P+    L     PTL   ++   + S   T
Sbjct: 68  PSSTPTLTPSSTPTLTPQPILTRSSTPTLTPSSPPTLTPSNTPTLTPSNTPTLTPSNTPT 127

Query: 458 LHKSTSSSSVSPSFP-----EEPVLEAVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEK 512
           L  S++ +    S P       P+L   ST    P   PI +        P         
Sbjct: 128 LTPSSTPTLTPSSTPTLTPSSRPILTRSSTPTLTPSSRPILTRSSTPTLTPSSTPTLTPS 187

Query: 513 ETPTNVRQFLPPSRQSSRSL 532
            TPT      P    SSR +
Sbjct: 188 STPTLTPSSTPTLTPSSRPI 207


>gi|226371669 discs large homolog 7 isoform b [Homo sapiens]
          Length = 842

 Score = 36.6 bits (83), Expect = 0.087
 Identities = 41/170 (24%), Positives = 73/170 (42%), Gaps = 14/170 (8%)

Query: 364 PRPRSLHERILEEIKAERKLRPVSPEEIRRSRLDVTTPESTKNLVESSMVNGGLTSQTKE 423
           P PR   E+ + + K ++ ++PV P  +R +R      +     V S+     +T    E
Sbjct: 177 PGPRQTSEKKVSD-KEKKVVQPVMPTSLRMTRSATQAAKQVPRTVSSTTARKPVTRAANE 235

Query: 424 NGLSTSQQVPAQRKKLLRAPTLAELDSS---ESEEETLHKSTSSSS-VSPS--FPEEPVL 477
           N      +VP++ +      T  +   S   +SEE TL+  T+++S ++P     +   L
Sbjct: 236 N--EPEGKVPSKGRPAKNVETKPDKGISCKVDSEENTLNSQTNATSGMNPDGVLSKMENL 293

Query: 478 EAVSTRKKPPKFLPISSTPQPERRQPPQ--RRHSIEKETPTNVRQFLPPS 525
             ++T K   K    S  P+    QP    + + +   TP +   FL PS
Sbjct: 294 PEINTAKIKGK---NSFAPKDFMFQPLDGLKTYQVTPMTPRSANAFLTPS 340


>gi|226371667 discs large homolog 7 isoform a [Homo sapiens]
          Length = 846

 Score = 36.6 bits (83), Expect = 0.087
 Identities = 41/170 (24%), Positives = 73/170 (42%), Gaps = 14/170 (8%)

Query: 364 PRPRSLHERILEEIKAERKLRPVSPEEIRRSRLDVTTPESTKNLVESSMVNGGLTSQTKE 423
           P PR   E+ + + K ++ ++PV P  +R +R      +     V S+     +T    E
Sbjct: 177 PGPRQTSEKKVSD-KEKKVVQPVMPTSLRMTRSATQAAKQVPRTVSSTTARKPVTRAANE 235

Query: 424 NGLSTSQQVPAQRKKLLRAPTLAELDSS---ESEEETLHKSTSSSS-VSPS--FPEEPVL 477
           N      +VP++ +      T  +   S   +SEE TL+  T+++S ++P     +   L
Sbjct: 236 N--EPEGKVPSKGRPAKNVETKPDKGISCKVDSEENTLNSQTNATSGMNPDGVLSKMENL 293

Query: 478 EAVSTRKKPPKFLPISSTPQPERRQPPQ--RRHSIEKETPTNVRQFLPPS 525
             ++T K   K    S  P+    QP    + + +   TP +   FL PS
Sbjct: 294 PEINTAKIKGK---NSFAPKDFMFQPLDGLKTYQVTPMTPRSANAFLTPS 340


>gi|118421085 leucine-rich repeat kinase 1 [Homo sapiens]
          Length = 1910

 Score = 36.2 bits (82), Expect = 0.11
 Identities = 45/192 (23%), Positives = 68/192 (35%), Gaps = 29/192 (15%)

Query: 335  KSAHEIILDFIRSRPPLNPVSARKLKPTPPRPRSLHERILEEIKAERKLRPVSPEEIRRS 394
            K +H+  L F ++ P       R++  TP  P    ER+    K+  K+ P      + S
Sbjct: 1107 KKSHQKSLSFSKTTP-------RRISHTPQTPLYTPERLQ---KSPAKMTPTKQAAFKES 1156

Query: 395  RLDVTTPESTKNLVESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESE 454
              D ++P     L +S +      +Q  E G S   + P   K+    P           
Sbjct: 1157 LKDSSSPGHDSPL-DSKITPQKRHTQAGE-GTSLETKTPRTPKRQGTQPP------GFLP 1208

Query: 455  EETLHKSTSSSSVSPSFPEEPVLEAVSTRKK-----------PPKFLPISSTPQPERRQP 503
              T   S +SS  SPS P  P       R++           PP+      TPQ +  Q 
Sbjct: 1209 NCTWPHSVNSSPESPSCPAPPTSSTAQPRRECLTPIRDPLRTPPRAAAFMGTPQNQTHQQ 1268

Query: 504  PQRRHSIEKETP 515
            P    +   E P
Sbjct: 1269 PHVLRAARAEEP 1280


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.130    0.378 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,798,311
Number of Sequences: 37866
Number of extensions: 1587838
Number of successful extensions: 10198
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 275
Number of HSP's that attempted gapping in prelim test: 9566
Number of HSP's gapped (non-prelim): 835
length of query: 742
length of database: 18,247,518
effective HSP length: 110
effective length of query: 632
effective length of database: 14,082,258
effective search space: 8899987056
effective search space used: 8899987056
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.