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Search of human proteins with 187607071
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|187607071 ligand of numb-protein X 1 isoform b [Homo
sapiens]
(632 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens] 1277 0.0
gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens] 1217 0.0
gi|24025688 ligand of numb-protein X 2 [Homo sapiens] 484 e-136
gi|148746189 multiple PDZ domain protein [Homo sapiens] 209 5e-54
gi|112382257 InaD-like [Homo sapiens] 154 2e-37
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 111 2e-24
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 103 6e-22
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 103 6e-22
gi|45827729 scribble isoform b [Homo sapiens] 101 2e-21
gi|45827731 scribble isoform a [Homo sapiens] 101 2e-21
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 98 3e-20
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 98 3e-20
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 95 2e-19
gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo sa... 92 1e-18
gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo sa... 92 1e-18
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 84 5e-16
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 84 5e-16
gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens] 81 3e-15
gi|119120907 par-3 partitioning defective 3 homolog B isoform a ... 80 7e-15
gi|119120903 par-3 partitioning defective 3 homolog B isoform c ... 80 7e-15
gi|87196343 PDZ domain containing 2 [Homo sapiens] 79 1e-14
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 77 4e-14
gi|122937249 glutamate receptor interacting protein 2 [Homo sapi... 77 4e-14
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 77 5e-14
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 75 1e-13
gi|223890252 glutamate receptor interacting protein 1 [Homo sapi... 74 3e-13
gi|218505835 membrane-associated guanylate kinase-related 3 iso... 71 3e-12
gi|155969695 membrane-associated guanylate kinase-related 3 iso... 71 3e-12
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 69 1e-11
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom... 67 5e-11
>gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens]
Length = 632
Score = 1277 bits (3305), Expect = 0.0
Identities = 632/632 (100%), Positives = 632/632 (100%)
Query: 1 MKALLLLVLPWLSPANYIDNVGNLHFLYSELCKGASHYGLTKDRKRRSQDGCPDGCASLT 60
MKALLLLVLPWLSPANYIDNVGNLHFLYSELCKGASHYGLTKDRKRRSQDGCPDGCASLT
Sbjct: 1 MKALLLLVLPWLSPANYIDNVGNLHFLYSELCKGASHYGLTKDRKRRSQDGCPDGCASLT 60
Query: 61 ATAPSPEVSAAATISLMTDEPGLDNPAYVSSAEDGQPAISPVDSGRSNRTRARPFERSTI 120
ATAPSPEVSAAATISLMTDEPGLDNPAYVSSAEDGQPAISPVDSGRSNRTRARPFERSTI
Sbjct: 61 ATAPSPEVSAAATISLMTDEPGLDNPAYVSSAEDGQPAISPVDSGRSNRTRARPFERSTI 120
Query: 121 RSRSFKKINRALSVLRRTKSGSAVANHADQGRENSENTTAPEVFPRLYHLIPDGEITSIK 180
RSRSFKKINRALSVLRRTKSGSAVANHADQGRENSENTTAPEVFPRLYHLIPDGEITSIK
Sbjct: 121 RSRSFKKINRALSVLRRTKSGSAVANHADQGRENSENTTAPEVFPRLYHLIPDGEITSIK 180
Query: 181 INRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVP 240
INRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVP
Sbjct: 181 INRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVP 240
Query: 241 HNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIK 300
HNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIK
Sbjct: 241 HNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIK 300
Query: 301 LVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRV 360
LVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRV
Sbjct: 301 LVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRV 360
Query: 361 HLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGE 420
HLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGE
Sbjct: 361 HLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGE 420
Query: 421 SLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVA 480
SLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVA
Sbjct: 421 SLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVA 480
Query: 481 LLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNC 540
LLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNC
Sbjct: 481 LLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNC 540
Query: 541 KDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRS 600
KDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRS
Sbjct: 541 KDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRS 600
Query: 601 TSGMIHACLARLLKELKGRITLTIVSWPGTFL 632
TSGMIHACLARLLKELKGRITLTIVSWPGTFL
Sbjct: 601 TSGMIHACLARLLKELKGRITLTIVSWPGTFL 632
>gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens]
Length = 728
Score = 1217 bits (3148), Expect = 0.0
Identities = 605/628 (96%), Positives = 610/628 (97%)
Query: 5 LLLVLPWLSPANYIDNVGNLHFLYSELCKGASHYGLTKDRKRRSQDGCPDGCASLTATAP 64
LL+ P+ + +L + CKGASHYGLTKDRKRRSQDGCPDGCASLTATAP
Sbjct: 101 LLVTCPFREHCTQVLQRCDLEHHFQTSCKGASHYGLTKDRKRRSQDGCPDGCASLTATAP 160
Query: 65 SPEVSAAATISLMTDEPGLDNPAYVSSAEDGQPAISPVDSGRSNRTRARPFERSTIRSRS 124
SPEVSAAATISLMTDEPGLDNPAYVSSAEDGQPAISPVDSGRSNRTRARPFERSTIRSRS
Sbjct: 161 SPEVSAAATISLMTDEPGLDNPAYVSSAEDGQPAISPVDSGRSNRTRARPFERSTIRSRS 220
Query: 125 FKKINRALSVLRRTKSGSAVANHADQGRENSENTTAPEVFPRLYHLIPDGEITSIKINRV 184
FKKINRALSVLRRTKSGSAVANHADQGRENSENTTAPEVFPRLYHLIPDGEITSIKINRV
Sbjct: 221 FKKINRALSVLRRTKSGSAVANHADQGRENSENTTAPEVFPRLYHLIPDGEITSIKINRV 280
Query: 185 DPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYA 244
DPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYA
Sbjct: 281 DPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYA 340
Query: 245 VRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRK 304
VRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRK
Sbjct: 341 VRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRK 400
Query: 305 VDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVV 364
VDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVV
Sbjct: 401 VDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVV 460
Query: 365 SRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGM 424
SRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGM
Sbjct: 461 SRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGM 520
Query: 425 TVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKR 484
TVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKR
Sbjct: 521 TVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKR 580
Query: 485 TSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIV 544
TSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIV
Sbjct: 581 TSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIV 640
Query: 545 LRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGM 604
LRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGM
Sbjct: 641 LRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGM 700
Query: 605 IHACLARLLKELKGRITLTIVSWPGTFL 632
IHACLARLLKELKGRITLTIVSWPGTFL
Sbjct: 701 IHACLARLLKELKGRITLTIVSWPGTFL 728
>gi|24025688 ligand of numb-protein X 2 [Homo sapiens]
Length = 690
Score = 484 bits (1246), Expect = e-136
Identities = 250/469 (53%), Positives = 339/469 (72%), Gaps = 11/469 (2%)
Query: 171 IPDGEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILK 230
+P+GEIT+I+I+R +P L I +VGG+ETPL++I+IQ +YRDGVIARDGRLL GD IL+
Sbjct: 226 LPEGEITTIEIHRSNPYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQ 285
Query: 231 VNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILNK 290
VN +ISNV HNYA +L QPC L LTV+RE++F +R + + D+ PR++ F V L+K
Sbjct: 286 VNNYNISNVSHNYARAVLSQPCNTLHLTVLRERRFGNRAHNHS-DSNSPREEIFQVALHK 344
Query: 291 SSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAA 350
EQLGIKLVR+ DEPGVFI ++L+GG+A + G+L NDRVLAINGHDL+YG+PE AA
Sbjct: 345 RDSGEQLGIKLVRRTDEPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAA 404
Query: 351 HLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPG---ERSNTPKPLHPTITC 407
+IQAS RV+L ++R + + + +EAG +S+ S P R ++ K L +TC
Sbjct: 405 QIIQASGERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTC 464
Query: 408 HEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDG 467
EK + ++K+P ESLGMTVAGG + +LPI+V SV P G ++RDGRIK GD+LLN++G
Sbjct: 465 QEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNING 524
Query: 468 VELTEVSRSEAVALLKRTSSS--IVLKALEVK--EYEPQEDCSSPAALDSNHNMAPPSDW 523
++LT +S SEAVA+LK +++S + LKALEV+ E Q P+ N A W
Sbjct: 525 IDLTNLSHSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDA---SW 581
Query: 524 SPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYN 583
SPSWVMWL LP L++C DIVLRR+ GS GF IVGGYEE + N+PFFIK+IV GTPAY
Sbjct: 582 SPSWVMWLGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYY 641
Query: 584 DGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTIVSWPGTFL 632
DGR++CGD+++AVNG ST GM H+ L +LKE + ++TLT++ WPG+ +
Sbjct: 642 DGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTVICWPGSLV 690
Score = 106 bits (264), Expect = 7e-23
Identities = 101/401 (25%), Positives = 170/401 (42%), Gaps = 67/401 (16%)
Query: 132 LSVLRRTKSGSAVANHADQGRENSENTTAPEVFPRLYHLIPDGEITSIKINRVDPSESLS 191
L+VLR + G+ NH+D P EI + +++ D E L
Sbjct: 312 LTVLRERRFGNRAHNHSDSNS-------------------PREEIFQVALHKRDSGEQLG 352
Query: 192 IRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQP 251
I+LV ++ P V I+ + G+ A+DGRL D +L +NG D+ A ++++
Sbjct: 353 IKLVRRTDEPGVFIL--DLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQAS 410
Query: 252 CQVLWLTVMREQK------------FRSRNNGQAPDAYRPRDDSF------------HVI 287
+ + LT+ R K S + P Y R S H+
Sbjct: 411 GERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHIT 470
Query: 288 LNKSSPEEQLGIKLV----RKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRY 343
+ K P E LG+ + K E +F+ +V G R G+++ D +L ING DL
Sbjct: 471 V-KKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTN 529
Query: 344 GSPESAAHLIQASER---------RVHLV-VSRQVRQRSPDIFQEAGWNSNGSWSPGPGE 393
S A +++AS V +V + Q + P F E +++ SWSP
Sbjct: 530 LSHSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDA--SWSPSWVM 587
Query: 394 RSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRD 453
P LH +CH+ V +++ S G ++ GG + P ++ ++ G D
Sbjct: 588 WLGLPSTLH---SCHDIV--LRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYD 642
Query: 454 GRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKAL 494
GR+K GD+++ V+G+ +S S V +LK + + L +
Sbjct: 643 GRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTVI 683
Score = 37.0 bits (84), Expect = 0.055
Identities = 27/106 (25%), Positives = 44/106 (41%), Gaps = 18/106 (16%)
Query: 5 LLLVLPWLSPANYIDNVGNLHFLYSELCKGASHYGLTKDRKRRSQDGC------------ 52
LL++ P+ S + +L C GASH + +R++ S+
Sbjct: 110 LLVLCPFSSVCKDVMQRCDLEAHLKNRCPGASHRRVALERRKTSRTQAEIENENGPTLLD 169
Query: 53 ------PDGCASLTATAPSPEVSAAATISLMTDEPGLDNPAYVSSA 92
P+ T P +A++S ++EPGLDNPA+ SA
Sbjct: 170 PAGTLSPEADCLGTGAVPVERHLTSASLSTWSEEPGLDNPAFEESA 215
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 209 bits (533), Expect = 5e-54
Identities = 152/488 (31%), Positives = 248/488 (50%), Gaps = 64/488 (13%)
Query: 154 NSENTTAPEVF---PRLYHLIPDGEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHI 210
N+ ++ P +F P +IP E T+I+I++ LSI VGGS+T L III +
Sbjct: 1603 NTSRSSTPAIFASDPATCPIIPGCE-TTIEISKGRTGLGLSI--VGGSDTLLGAIIIHEV 1659
Query: 211 YRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNN 270
Y +G +DGRL GD IL+VNG+D+ H+ A+ +LRQ Q + LT+ R+
Sbjct: 1660 YEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRD-------- 1711
Query: 271 GQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEEN 330
+AP D+ + L K P + LG+ +V K ++ GVF+ +++ GG+A G+L +
Sbjct: 1712 -EAPYKEEEVCDTLTIELQK-KPGKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQG 1769
Query: 331 DRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPG 390
D++L +NG D+R + E+ A L++ SE + S F +G +++ S
Sbjct: 1770 DQILMVNGEDVRNATQEAVAALLKVSEGSL-----------SSFTFPLSGSSTSESL--- 1815
Query: 391 PGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVI 450
E S+ L I + V ++K P +SLG+++AGG D+PI++ + P GV
Sbjct: 1816 --ESSSKKNALASEIQ-GLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVA 1872
Query: 451 SRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKA-----LEVKEYEPQEDC 505
++ +++ GD ++ + G ++ ++AV LLK S SI ++ + V QE
Sbjct: 1873 AQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPA 1932
Query: 506 SSPAALDS-------NHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIV 558
SS + ++ PP CK I L R G LGF IV
Sbjct: 1933 SSSLSFTGLTSSSIFQDDLGPP------------------QCKSITLERGPDG-LGFSIV 1973
Query: 559 GGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKG 618
GGY +G+ P ++K++ A DGR++ GD ++AVNG+S G+ H +LK KG
Sbjct: 1974 GGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKG 2033
Query: 619 RITLTIVS 626
+TL ++S
Sbjct: 2034 TVTLMVLS 2041
Score = 117 bits (294), Expect = 2e-26
Identities = 117/518 (22%), Positives = 199/518 (38%), Gaps = 98/518 (18%)
Query: 154 NSENTTAPEVFPRLYHLIPDGEITSIK-INRVD-PSESLSIRLVGGSETPLVHIIIQHIY 211
NSEN E P + +++S K + ++ P + + + E L +II+ +
Sbjct: 1453 NSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLT 1512
Query: 212 RDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMRE--------- 262
GV A DGRL GD IL V+ + P + LL+ + LT+ E
Sbjct: 1513 EHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPS 1572
Query: 263 -------QKFRSRNNGQAPDAYRPRDDSFHVILNKSSP---------------------- 293
+K S + P + P +S S+P
Sbjct: 1573 AAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEI 1632
Query: 294 ---EEQLGIKLVRKVDE--PGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPES 348
LG+ +V D + I V + G A + G+L D++L +NG DLR + +
Sbjct: 1633 SKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDE 1692
Query: 349 AAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCH 408
A ++++ + +RV L + R P C
Sbjct: 1693 AINVLRQTPQRVRLTLYRD------------------------------EAPYKEEEVCD 1722
Query: 409 EKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGV 468
+ +QK PG+ LG+++ G + D ++V + GG+ DGR+ GD +L V+G
Sbjct: 1723 TLTIELQKKPGKGLGLSIVG----KRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGE 1778
Query: 469 ELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWV 528
++ ++ ALLK + S+ P S+ +L+S+
Sbjct: 1779 DVRNATQEAVAALLKVSEGSLSSFTF------PLSGSSTSESLESSSKKN---------- 1822
Query: 529 MWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIR 588
L + + + +++ SLG I GG G+ P FI + A ++R
Sbjct: 1823 ---ALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLR 1879
Query: 589 CGDILLAVNGRSTSGMIHACLARLLKELKGRITLTIVS 626
GD ++ + G ST GM H LLK G I + +V+
Sbjct: 1880 VGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVA 1917
Score = 94.0 bits (232), Expect = 4e-19
Identities = 85/328 (25%), Positives = 153/328 (46%), Gaps = 38/328 (11%)
Query: 307 EPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYG-SPESAAHLIQASERRVHLVVS 365
E G+F+ + +G VA+R G+L+E D++LAING L + + A ++Q ++ V LV++
Sbjct: 162 ELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAISILQKAKDTVQLVIA 221
Query: 366 RQVRQR--SPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLG 423
R + SP + S P S +P H + + + D G LG
Sbjct: 222 RGSLPQLVSPIV------------SRSPSAASTISAHSNPVHWQHMETIELVND-GSGLG 268
Query: 424 MTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLK 483
+ GG + + V ++ PGGV + GR+ +GD +L + +L +S + +L+
Sbjct: 269 FGIIGGKA-----TGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLR 323
Query: 484 RTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYN-CKD 542
+ + + L E+ ++P AL + +P S +P + + + D
Sbjct: 324 QCGNRVKLMIAR----GAIEERTAPTALGITLSSSPTS--TPELRVDASTQKGEESETFD 377
Query: 543 IVLRRNTAGSLGFCIVGGYEEYNGNKPF-----FIKSIVEGTPAYNDGRIRCGDILLAVN 597
+ L +N G LG I G Y G+K F+KSI + + +DGRI+ GD ++AV+
Sbjct: 378 VELTKNVQG-LGITIAG----YIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVD 432
Query: 598 GRSTSGMIHACLARLLKELKGRITLTIV 625
G + G + +L+ + LT++
Sbjct: 433 GTNLQGFTNQQAVEVLRHTGQTVLLTLM 460
Score = 93.6 bits (231), Expect = 5e-19
Identities = 90/362 (24%), Positives = 153/362 (42%), Gaps = 43/362 (11%)
Query: 186 PSESLSIRLVG--GSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISN-VPHN 242
PS L +VG + I +Q I V RDGRL D IL +NG + + H
Sbjct: 144 PSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQ 203
Query: 243 YAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRP----RDDSFHVILNKSSPEEQLG 298
A+ +L++ + L + R G P P + I S+P
Sbjct: 204 QAISILQKAKDTVQLVIAR---------GSLPQLVSPIVSRSPSAASTISAHSNPVHWQH 254
Query: 299 IKLVRKVDE-------------PGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGS 345
++ + V++ GV + +L GGVA +HG+L D +L I DL S
Sbjct: 255 METIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMS 314
Query: 346 PESAAHLIQASERRVHLVVSR-QVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPT 404
E A +++ RV L+++R + +R+ +S+ + +P ++T K
Sbjct: 315 SEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEESE 374
Query: 405 ITCHEKVVNIQKDPGESLGMTVAGGASHREWD-LPIYVISVEPGGVISRDGRIKTGDILL 463
E N+Q LG+T+AG ++ + I+V S+ + DGRI+ GD ++
Sbjct: 375 TFDVELTKNVQ-----GLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQII 429
Query: 464 NVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDW 523
VDG L + +AV +L+ T +++L + + A L S ++ +D
Sbjct: 430 AVDGTNLQGFTNQQAVEVLRHTGQTVLLTLM-------RRGMKQEAELMSREDVTKDADL 482
Query: 524 SP 525
SP
Sbjct: 483 SP 484
Score = 88.6 bits (218), Expect = 2e-17
Identities = 113/499 (22%), Positives = 199/499 (39%), Gaps = 95/499 (19%)
Query: 174 GEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNG 233
GE+ I++ + L + L G + + + I I +G +DGRL D +L++NG
Sbjct: 1346 GELHMIELEK--GHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEING 1403
Query: 234 MDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILNKSS- 292
+ H A +++ + + +R + ++ +A P + + NK +
Sbjct: 1404 QILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETE 1463
Query: 293 -----------------------PEEQ--LGIKLVRKVDEPGVFIFNVLDGGVAYRHGQL 327
P++Q LGI + + GV I ++ + GVA G+L
Sbjct: 1464 PTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRL 1523
Query: 328 EENDRVLAINGHDLRYGSP-ESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSN-- 384
+ D++LA++ ++ G P E L++ ++ V L + + S + AG S
Sbjct: 1524 KVGDQILAVD-DEIVVGYPIEKFISLLKTAKMTVKLTIHAE-NPDSQAVPSAAGAASGEK 1581
Query: 385 ----------GSWSPGPGERSNTPKPLHPTI------TCH-----EKVVNIQKDPGESLG 423
S SP P NT + P I TC E + I K LG
Sbjct: 1582 KNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKG-RTGLG 1640
Query: 424 MTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLK 483
+++ GG+ + I+ + E G +DGR+ GD +L V+G++L + + EA+ +L+
Sbjct: 1641 LSIVGGSDTLLGAIIIHEVYEE--GAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLR 1698
Query: 484 RTSSSIVLKAL-EVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKD 542
+T + L + Y+ +E C +
Sbjct: 1699 QTPQRVRLTLYRDEAPYKEEEVCDT---------------------------------LT 1725
Query: 543 IVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTS 602
I L++ LG IVG + F+ IV+G A DGR+ GD +L VNG
Sbjct: 1726 IELQKKPGKGLGLSIVG----KRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVR 1781
Query: 603 GMIHACLARLLKELKGRIT 621
+A LLK +G ++
Sbjct: 1782 NATQEAVAALLKVSEGSLS 1800
Score = 72.8 bits (177), Expect = 9e-13
Identities = 87/362 (24%), Positives = 143/362 (39%), Gaps = 47/362 (12%)
Query: 297 LGIKLVRKVDEP--GVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQ 354
LG+ L D VFI + G A + G+L+ D +L ING L S ++A+ +I+
Sbjct: 1360 LGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIK 1419
Query: 355 ASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTP-KPLHPTITCHEKVVN 413
+ +V ++ R+ D + + P P N K PT+T + V+
Sbjct: 1420 CAPSKVKIIFI-----RNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVD 1474
Query: 414 IQ-----------KDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDIL 462
+ KD G LG+ + S + + + S+ GV + DGR+K GD +
Sbjct: 1475 LSSFKNVQHLELPKDQG-GLGIAI----SEEDTLSGVIIKSLTEHGVAATDGRLKVGDQI 1529
Query: 463 LNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAAL-----DSNHNM 517
L VD + + ++LLK T+ V + + + Q S+ A +S+ ++
Sbjct: 1530 LAVDDEIVVGYPIEKFISLLK-TAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSL 1588
Query: 518 APPSDWSPSWVMWLELPR---------------CLYNCKDIVLRRNTAGSLGFCIVGGYE 562
P SP R + C+ + LG IVGG +
Sbjct: 1589 MVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSD 1648
Query: 563 EYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITL 622
G I + E A DGR+ GD +L VNG H +L++ R+ L
Sbjct: 1649 TLLG--AIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRL 1706
Query: 623 TI 624
T+
Sbjct: 1707 TL 1708
Score = 70.1 bits (170), Expect = 6e-12
Identities = 55/220 (25%), Positives = 98/220 (44%), Gaps = 23/220 (10%)
Query: 408 HEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDG 467
H +V + K P LG +V G S +L I+V ++ G V RDGR+K D +L ++G
Sbjct: 134 HVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAING 193
Query: 468 VELTE-VSRSEAVALLKRTSSSI--VLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWS 524
L + ++ +A+++L++ ++ V+ + + SP+A + + P W
Sbjct: 194 QALDQTITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQ 253
Query: 525 PSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYND 584
+ L N LGF I+GG +K+I+ G A
Sbjct: 254 HMETIELV---------------NDGSGLGFGIIGGKA-----TGVIVKTILPGGVADQH 293
Query: 585 GRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTI 624
GR+ GD +L + +GM +A++L++ R+ L I
Sbjct: 294 GRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMI 333
Score = 65.1 bits (157), Expect = 2e-10
Identities = 103/537 (19%), Positives = 205/537 (38%), Gaps = 108/537 (20%)
Query: 181 INRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVP 240
I V+ L ++GG T +I++ I GV + GRL GD ILK+ D++ +
Sbjct: 258 IELVNDGSGLGFGIIGGKATG---VIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMS 314
Query: 241 HNYAVRLLRQPCQVLWLTVMR---EQKFRSRNNG---------------QAPDAYRPRDD 282
++LRQ + L + R E++ G A +
Sbjct: 315 SEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEESE 374
Query: 283 SFHVILNKSSPEEQLGIKLV-----RKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAIN 337
+F V L K+ + LGI + +K++ G+F+ ++ G+++ D+++A++
Sbjct: 375 TFDVELTKNV--QGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVD 432
Query: 338 GHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPG------- 390
G +L+ + + A +++ + + V L + R+ ++ ++ + SP
Sbjct: 433 GTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKE 492
Query: 391 ------------------PGERSNTP-------------KPLHPTITCHEKVVNIQKD-- 417
P E P K +T ++++ I +
Sbjct: 493 NYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIV 552
Query: 418 --------PGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVE 469
LG+++ H ++ SV P G + G++ +GD LL V+G+
Sbjct: 553 VAHVSKFSENSGLGISLEATVGHH------FIRSVLPEGPVGHSGKLFSGDELLEVNGIT 606
Query: 470 LTEVSRSEAVALLKRTSSSIV---------------LKALEVKEYE----PQEDCSSPAA 510
L + + V +LK + L +L++ + E P D
Sbjct: 607 LLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIG 666
Query: 511 LDSNHNMAPPSDWSPSWVMWLELPRCLYNC--KDIVLRRNTAGSLGFCIVGGYEEYN-GN 567
+ + ++ P ++ + I L + + G LGF I+ + + +
Sbjct: 667 SSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKG-LGFSILDYQDPIDPAS 725
Query: 568 KPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTI 624
I+S+V G A DGR+ GD L+ VN + ++ L ++ LKG + T+
Sbjct: 726 TVIIIRSLVPGGIAEKDGRLLPGDRLMFVN---DVNLENSSLEEAVEALKGAPSGTV 779
Score = 60.1 bits (144), Expect = 6e-09
Identities = 63/241 (26%), Positives = 105/241 (43%), Gaps = 28/241 (11%)
Query: 409 EKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGV 468
E+ +NI K SLGMTV+ L + V S+ GG ISRDGRI GD +L+++
Sbjct: 1006 ERTINIAKG-NSSLGMTVSANKD----GLGMIVRSIIHGGAISRDGRIAIGDCILSINEE 1060
Query: 469 ELTEVSRSEAVALLKRTS--------SSIVLKALEVKEYEPQEDCSSPAALD-----SNH 515
V+ ++A A+L+R S + + + LE + + ALD +
Sbjct: 1061 STISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGR 1120
Query: 516 NMAPPSDWSPSWVMWLELPRCLYN----CKDIVLRRNTAGSLGFCIVG----GYEEYNGN 567
++ + EL Y+ + + L R + SLG IVG G NG
Sbjct: 1121 DIPELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGE 1180
Query: 568 --KPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTIV 625
+ FIK ++E +PA +G ++ GD ++ V+G H +++ + +
Sbjct: 1181 VMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQ 1240
Query: 626 S 626
S
Sbjct: 1241 S 1241
Score = 59.3 bits (142), Expect = 1e-08
Identities = 83/431 (19%), Positives = 160/431 (37%), Gaps = 90/431 (20%)
Query: 282 DSFHVILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHD- 340
+SF +N + LG+ + D G+ + +++ GG R G++ D +L+IN
Sbjct: 1003 ESFERTINIAKGNSSLGMTVSANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEEST 1062
Query: 341 LRYGSPESAA----HLIQASERRVHLVVSRQVRQRSPDIFQEAG--------WNSNGSWS 388
+ + ++ A H + + ++ V + + + + Q++G + G
Sbjct: 1063 ISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDI 1122
Query: 389 P-------GPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGG------ASHREW 435
P G GE S + + V + ++P +SLG+++ GG S+ E
Sbjct: 1123 PELPEREEGEGEESELQNTAYSNWN-QPRRVELWREPSKSLGISIVGGRGMGSRLSNGEV 1181
Query: 436 DLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVL---- 491
I++ V ++G +K GD ++ VDG++L + S +AV +++ + +V
Sbjct: 1182 MRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQS 1241
Query: 492 --------------------------------------KALEVKEYEPQED--CSSP--- 508
KA E EP++ CS P
Sbjct: 1242 IINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPPP 1301
Query: 509 ----AALDSNHNMAPPS----------DWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLG 554
A + S+H + S ++ SW E L ++ LG
Sbjct: 1302 PSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLG 1361
Query: 555 FCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLK 614
+ G + FI I A DGR++ D LL +NG+ G H + ++K
Sbjct: 1362 LSLAGNKD--RSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIK 1419
Query: 615 ELKGRITLTIV 625
++ + +
Sbjct: 1420 CAPSKVKIIFI 1430
Score = 57.0 bits (136), Expect = 5e-08
Identities = 58/217 (26%), Positives = 96/217 (44%), Gaps = 13/217 (5%)
Query: 414 IQKDPGES-LGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTE 472
I+ + G S LG+++AG + ++++ ++P G +DGR++ D LL ++G L
Sbjct: 1351 IELEKGHSGLGLSLAGNKDRSR--MSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYG 1408
Query: 473 VSRSEAVALLKRTSSSIVLKALEVKEYEPQ-EDCSSPAA--LDSNHNMAPPSDWSPSWVM 529
S A +++K S + + + K+ Q C A L SN + P+ V
Sbjct: 1409 RSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPT-VT 1467
Query: 530 WLELPRCLYNCKDI--VLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRI 587
+ L + K++ + G LG I E + IKS+ E A DGR+
Sbjct: 1468 TSDAAVDLSSFKNVQHLELPKDQGGLGIAI----SEEDTLSGVIIKSLTEHGVAATDGRL 1523
Query: 588 RCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTI 624
+ GD +LAV+ G LLK K + LTI
Sbjct: 1524 KVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI 1560
Score = 49.3 bits (116), Expect = 1e-05
Identities = 26/74 (35%), Positives = 42/74 (56%), Gaps = 8/74 (10%)
Query: 185 DPSESLSIRLVGG--------SETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDI 236
+PS+SL I +VGG + + I I+H+ D ++G L PGD I++V+GMD+
Sbjct: 1157 EPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDL 1216
Query: 237 SNVPHNYAVRLLRQ 250
+ H AV +R+
Sbjct: 1217 RDASHEQAVEAIRK 1230
Score = 45.1 bits (105), Expect = 2e-04
Identities = 53/210 (25%), Positives = 87/210 (41%), Gaps = 51/210 (24%)
Query: 205 IIIQHIYRDGVIARDGRLLPGDIILKVN------------------------GMDISNVP 240
+I++ I G I+RDGR+ GD IL +N + I+ VP
Sbjct: 1031 MIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLRRHSLIGPDIKITYVP 1090
Query: 241 ----HNYAVRLLRQPCQVLWLTVMREQKFRS------RNNGQAPD------AYRPRDDSF 284
+ + L +Q +V+ L + R R G+ + AY +
Sbjct: 1091 AEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEESELQNTAYSNWNQPR 1150
Query: 285 HVILNKSSPEEQLGIKLV--RKVDEP--------GVFIFNVLDGGVAYRHGQLEENDRVL 334
V L + P + LGI +V R + G+FI +VL+ A ++G L+ DR++
Sbjct: 1151 RVELWRE-PSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIV 1209
Query: 335 AINGHDLRYGSPESAAHLIQASERRVHLVV 364
++G DLR S E A I+ + V +V
Sbjct: 1210 EVDGMDLRDASHEQAVEAIRKAGNPVVFMV 1239
Score = 37.4 bits (85), Expect = 0.042
Identities = 23/88 (26%), Positives = 42/88 (47%), Gaps = 5/88 (5%)
Query: 175 EITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGM 234
EI +++ + L I L E + H I+ + +G + G+L GD +L+VNG+
Sbjct: 550 EIVVAHVSKFSENSGLGISL----EATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGI 605
Query: 235 DISNVPHNYAVRLLRQ-PCQVLWLTVMR 261
+ H V +L++ P +V + R
Sbjct: 606 TLLGENHQDVVNILKELPIEVTMVCCRR 633
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 154 bits (389), Expect = 2e-37
Identities = 126/455 (27%), Positives = 218/455 (47%), Gaps = 45/455 (9%)
Query: 61 ATAPSPEVSAAATISLMTDEPGLDNPAYVSSAEDGQPAISPVDSGRSNRTRARPFERSTI 120
A P P S++ S + D+ G + +SS EDG V+ G + F+ +
Sbjct: 1329 AVTPFPVPSSSP--SSIEDQSGTEP---ISSEEDGS-----VEVGIKQLPESESFKLAVS 1378
Query: 121 RSRSFKKINRALSVLRRTKSGSAVANHA-DQGRENSENTTAP-EVFPRLYHLIPDGEITS 178
+ + K + + A + H+ D AP V P ++P E+
Sbjct: 1379 QMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMI- 1437
Query: 179 IKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISN 238
I+I++ L + +VGG +TPL I+I +Y +G ARDGRL GD IL+VNG+D+ N
Sbjct: 1438 IEISK--GRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRN 1495
Query: 239 VPHNYAVRLLRQPCQVLWLTVMR-EQKFRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQL 297
H A+ LRQ Q + L V R E +R N + F V L K + L
Sbjct: 1496 SSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEI----------FPVDLQKKA-GRGL 1544
Query: 298 GIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASE 357
G+ +V K + GVFI +++ GG A G+L + D++L++NG D+R S E+ A +++ ++
Sbjct: 1545 GLSIVGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQ 1604
Query: 358 RRVHLVV----------SRQVRQRSPDIFQEAGWNSNGSWSP--------GPGERSNTPK 399
V L + +R Q S Q A + + S++P +R + P
Sbjct: 1605 GLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPS 1664
Query: 400 PLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTG 459
+ + V I ++ ++LG+++AGG D+P+++ ++ GV +R ++K G
Sbjct: 1665 QKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVG 1724
Query: 460 DILLNVDGVELTEVSRSEAVALLKRTSSSIVLKAL 494
D +++++G L +S ++ V LLK I+L+ +
Sbjct: 1725 DRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVV 1759
Score = 95.1 bits (235), Expect = 2e-19
Identities = 90/335 (26%), Positives = 152/335 (45%), Gaps = 56/335 (16%)
Query: 304 KVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYG-SPESAAHLIQASERRVHL 362
KVD +F+ +V G VA R +L+END++LAIN L S + A L+Q + + L
Sbjct: 159 KVD---IFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAIALLQQTTGSLRL 215
Query: 363 VVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLH----PTITC--HEKVVNIQK 416
+V+R+ +S+T L+ P C H + V +
Sbjct: 216 IVAREPVHT----------------------KSSTSSSLNDTTLPETVCWGHVEEVELIN 253
Query: 417 DPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRS 476
D G LG + GG + + V ++ PGG+ RDGR++TGD +L + G + ++
Sbjct: 254 D-GSGLGFGIVGGKTSG-----VVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSE 307
Query: 477 EAVALLKRTSSSI-VLKALEVK---EYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLE 532
+ +L+ +S+ +L A + P + P AL + + P SD S
Sbjct: 308 QVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSS-------- 359
Query: 533 LPRCLYNCKDIVLRRNTAGSLGFCIVG--GYEEYNGNKPFFIKSIVEGTPAYNDGRIRCG 590
L+ ++ L R SLG IVG G ++KSI+ G+ AY++G I+
Sbjct: 360 ----LFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVN 415
Query: 591 DILLAVNGRSTSGMIHACLARLLKELKGRITLTIV 625
D ++AV+G + G + + +L+ + LT+V
Sbjct: 416 DKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLV 450
Score = 95.1 bits (235), Expect = 2e-19
Identities = 91/360 (25%), Positives = 151/360 (41%), Gaps = 54/360 (15%)
Query: 286 VILNKSSPEEQLGIKLVRKVDEP--GVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRY 343
+I+ S LG+ +V D P + I V + G A R G+L D++L +NG DLR
Sbjct: 1436 MIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRN 1495
Query: 344 GSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHP 403
S E A ++ + ++V LVV R EA + + P
Sbjct: 1496 SSHEEAITALRQTPQKVRLVVYRD----------EAHYRDEENLEIFP------------ 1533
Query: 404 TITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILL 463
V++QK G LG+++ G + +++ + GG DGR+ GD +L
Sbjct: 1534 --------VDLQKKAGRGLGLSIVGKRNGSG----VFISDIVKGGAADLDGRLIQGDQIL 1581
Query: 464 NVDGVELTEVSRSEAVALLKRTSSSIVLKA--LEVKEYEPQEDCS--SPAALDSNHNMAP 519
+V+G ++ S+ +LK + L+ L + S S + S H+
Sbjct: 1582 SVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCH 1641
Query: 520 PSDWSPSWVMWLEL--------PRCLYNCKD-----IVLRRNTAGSLGFCIVGGYEEYNG 566
PS ++P L P + D + + R + +LG I GG G
Sbjct: 1642 PS-FAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLG 1700
Query: 567 NKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTIVS 626
+ P FI I A +++ GD ++++NG+ G+ HA + LLK GRI L +V+
Sbjct: 1701 DIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVA 1760
Score = 80.1 bits (196), Expect = 6e-15
Identities = 88/335 (26%), Positives = 141/335 (42%), Gaps = 43/335 (12%)
Query: 203 VHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDIS-NVPHNYAVRLLRQPCQVLWLTVMR 261
V I ++ + V RD RL D IL +N + N+ H A+ LL+Q L L V R
Sbjct: 160 VDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAR 219
Query: 262 EQKF-RSRNNGQAPDAYRPRDDSF-HV----ILNKSSPEEQLGIKLVRKVDEPGVFIFNV 315
E +S + D P + HV ++N S LG +V GV + +
Sbjct: 220 EPVHTKSSTSSSLNDTTLPETVCWGHVEEVELINDGSG---LGFGIVGGKTS-GVVVRTI 275
Query: 316 LDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQ------VR 369
+ GG+A R G+L+ D +L I G +++ + E A +++ V ++V+R V
Sbjct: 276 VPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVT 335
Query: 370 QRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAG- 428
+P A S GPG S+ + + V + + G+SLG+ + G
Sbjct: 336 PPAPAALPVA---LPTVASKGPGSDSSLFETYN---------VELVRKDGQSLGIRIVGY 383
Query: 429 -GASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSS 487
G SH IYV S+ PG +G I+ D ++ VDGV + + + V +L+
Sbjct: 384 VGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQ 443
Query: 488 SIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSD 522
+ L + K S + PPSD
Sbjct: 444 VVHLTLVRRK------------TSSSTSPLEPPSD 466
Score = 70.5 bits (171), Expect = 5e-12
Identities = 58/218 (26%), Positives = 100/218 (45%), Gaps = 25/218 (11%)
Query: 412 VNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELT 471
++I++ LG +V S + I+V V+PG V RD R+K D +L ++ L
Sbjct: 135 IDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLD 194
Query: 472 E-VSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMW 530
+ +S +A+ALL++T+ S+ L + EP SS ++ ++ + P V W
Sbjct: 195 QNISHQQAIALLQQTTGSLRL----IVAREPVHTKSSTSSSLNDTTL-------PETVCW 243
Query: 531 LELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCG 590
+ V N LGF IVGG +++IV G A DGR++ G
Sbjct: 244 GHVEE--------VELINDGSGLGFGIVGGK-----TSGVVVRTIVPGGLADRDGRLQTG 290
Query: 591 DILLAVNGRSTSGMIHACLARLLKELKGRITLTIVSWP 628
D +L + G + GM +A++L+ + + + P
Sbjct: 291 DHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDP 328
Score = 64.3 bits (155), Expect = 3e-10
Identities = 55/247 (22%), Positives = 111/247 (44%), Gaps = 41/247 (16%)
Query: 180 KINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNV 239
++ ++ L +VGG + ++++ I G+ RDGRL GD ILK+ G ++ +
Sbjct: 248 EVELINDGSGLGFGIVGGKTSG---VVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGM 304
Query: 240 PHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYR----------PRDDS-----F 284
++LR + + V R+ AP A P DS +
Sbjct: 305 TSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSSLFETY 364
Query: 285 HVILNKSSPEEQLGIKLVRKV------DEPGVFIFNVLDGGVAYRHGQLEENDRVLAING 338
+V L + + LGI++V V + G+++ +++ G AY +G ++ ND+++A++G
Sbjct: 365 NVELVRKDGQS-LGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDG 423
Query: 339 HDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSP--GPGERSN 396
+++ + +++ + + VHL + R+ ++ S SP P +R
Sbjct: 424 VNIQGFANHDVVEVLRNAGQVVHLTLVRR--------------KTSSSTSPLEPPSDRGT 469
Query: 397 TPKPLHP 403
+PL P
Sbjct: 470 VVEPLKP 476
Score = 58.2 bits (139), Expect = 2e-08
Identities = 65/285 (22%), Positives = 104/285 (36%), Gaps = 68/285 (23%)
Query: 392 GERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGAS------HREWDLPIYVISVE 445
GE TP H ++V I ++P SLG+++ GG + + E I++ V
Sbjct: 1052 GEGEETPNFSH---WGPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVL 1108
Query: 446 PGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDC 505
+ +KTGD +L V GV+L S SEAV +K + +V + Q
Sbjct: 1109 EDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVV--------FIVQSLS 1160
Query: 506 SSPAALDSNHNMA-----------------------PPSDWSPSW--------------- 527
S+P + + HN A PP P +
Sbjct: 1161 STPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDA 1220
Query: 528 -------VMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTP 580
+ +LP L+ I+ LG + G + F+ I P
Sbjct: 1221 FTDQKIRQRYADLPGELH----IIELEKDKNGLGLSLAGNKD--RSRMSIFVVGINPEGP 1274
Query: 581 AYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTIV 625
A DGR+R GD LL +N + G H + ++K ++ L +
Sbjct: 1275 AAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFI 1319
Score = 51.6 bits (122), Expect = 2e-06
Identities = 59/270 (21%), Positives = 108/270 (40%), Gaps = 47/270 (17%)
Query: 296 QLGIKLVRKVDE-PGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQ 354
Q IK ++ +E G+FI VL+ A + L+ D++L ++G DL+ S A I+
Sbjct: 1087 QTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIK 1146
Query: 355 ASERRVHLVVSR--QVRQRSPDIFQEAG---WNSNGSWSPGPGERSNT-PKPL------- 401
+ V +V + P++ +A N N +R T P P+
Sbjct: 1147 NAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYK 1206
Query: 402 -----------------------HPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLP 438
+ + ++ ++KD LG+++AG +
Sbjct: 1207 ALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKN-GLGLSLAGNKDRSR--MS 1263
Query: 439 IYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKE 498
I+V+ + P G + DGR++ GD LL ++ L S A A++K S + L + ++
Sbjct: 1264 IFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNED 1323
Query: 499 YEPQ-------EDCSSPAALDSNHNMAPPS 521
Q SSP++++ P S
Sbjct: 1324 AVNQMAVTPFPVPSSSPSSIEDQSGTEPIS 1353
Score = 44.7 bits (104), Expect = 3e-04
Identities = 45/174 (25%), Positives = 74/174 (42%), Gaps = 30/174 (17%)
Query: 440 YVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKAL----- 494
Y+ S+ GG + G ++ D LL V+G++L SR EAV+ LK L
Sbjct: 582 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFD 641
Query: 495 -EVKEYEPQEDCSSPAALDSNHNMAPPSD---------WSPSWVMWLELPRCLYNCKDIV 544
E EP+ +S + +HNM ++ WSP +++ + +CK
Sbjct: 642 DEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPE----VKIVELVKDCK--- 694
Query: 545 LRRNTAGSLGFCIVGGYEEYNGNKP-FFIKSIVEGTPAYNDGRIRCGDILLAVN 597
LGF I+ + + + I+S+V A G + GD L++VN
Sbjct: 695 -------GLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVN 741
Score = 41.6 bits (96), Expect = 0.002
Identities = 52/248 (20%), Positives = 88/248 (35%), Gaps = 67/248 (27%)
Query: 185 DPSESLSIRLVGGSET--------PLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDI 236
+P+ SL I +VGG L I I+ + D + L GD IL+V+G+D+
Sbjct: 1074 EPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDL 1133
Query: 237 SNVPHNYAVRLLRQPCQVLWLTVMR-------------------------EQKFRSRNNG 271
N H+ AV ++ + V Q+ + + G
Sbjct: 1134 QNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQG 1193
Query: 272 QAPDAYR---------------PRDDSF----------------HVILNKSSPEEQLGIK 300
AP + +D+F H+I + LG+
Sbjct: 1194 TAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHII-ELEKDKNGLGLS 1252
Query: 301 LVRKVDEP--GVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASER 358
L D +F+ + G A G++ D +L IN L S ++A+ +I+ +
Sbjct: 1253 LAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPS 1312
Query: 359 RVHLVVSR 366
+V LV R
Sbjct: 1313 KVKLVFIR 1320
Score = 35.8 bits (81), Expect = 0.12
Identities = 18/45 (40%), Positives = 26/45 (57%)
Query: 205 IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLR 249
I+I+ + DGV R G LLPGD ++ VN + N AV +L+
Sbjct: 714 IVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILK 758
Score = 35.4 bits (80), Expect = 0.16
Identities = 25/85 (29%), Positives = 36/85 (42%), Gaps = 6/85 (7%)
Query: 552 SLGFCIVGGYEEY----NGN--KPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMI 605
SLG IVGG NG K FIK ++E +PA ++ GD +L V+G
Sbjct: 1078 SLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNAS 1137
Query: 606 HACLARLLKELKGRITLTIVSWPGT 630
H+ +K + + S T
Sbjct: 1138 HSEAVEAIKNAGNPVVFIVQSLSST 1162
Score = 33.9 bits (76), Expect = 0.47
Identities = 45/200 (22%), Positives = 71/200 (35%), Gaps = 36/200 (18%)
Query: 311 FIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQ 370
+I +++ GG G L+ D +L +NG L S A ++ LV R++
Sbjct: 582 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFD 641
Query: 371 RSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAG-- 428
+ E T L T H VN ++D L +
Sbjct: 642 DEASV----------------DEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVK 685
Query: 429 -----------GASHREWDLP-------IYVISVEPGGVISRDGRIKTGDILLNVDGVEL 470
G S ++ P I + S+ GV R G + GD L++V+ L
Sbjct: 686 IVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCL 745
Query: 471 TEVSRSEAVALLKRTSSSIV 490
S +EAV +LK +V
Sbjct: 746 DNTSLAEAVEILKAVPPGLV 765
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 111 bits (278), Expect = 2e-24
Identities = 102/347 (29%), Positives = 146/347 (42%), Gaps = 71/347 (20%)
Query: 306 DEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVS 365
D+PG+FI ++ GG A G+L ND VL +N D+ A ++ + V LVV
Sbjct: 156 DDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVR 215
Query: 366 RQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMT 425
R RQ P+ E VN+ K P + LG +
Sbjct: 216 R--RQPPPETIME---------------------------------VNLLKGP-KGLGFS 239
Query: 426 VAGGAS--HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLK 483
+AGG H D IY+ + GG +DGR++ GD LL V+ L +V EAVA LK
Sbjct: 240 IAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLK 299
Query: 484 RTSSSIVLK-----ALEVKE-YEPQEDCSSPAALDSNH---------------------- 515
TS + LK +L + + Y P + S+ AL NH
Sbjct: 300 NTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYPAP 359
Query: 516 NMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSI 575
PP+ +SP L + I+L + + G LGF IVGG + + F+ I
Sbjct: 360 PQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTG-LGFNIVGGED----GEGIFVSFI 414
Query: 576 VEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITL 622
+ G PA G +R GD +L+VNG + H A LK +T+
Sbjct: 415 LAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTI 461
Score = 89.7 bits (221), Expect = 7e-18
Identities = 94/357 (26%), Positives = 148/357 (41%), Gaps = 65/357 (18%)
Query: 187 SESLSIRLVGGSETPLVH----IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHN 242
+ L + GG + P V I I I G A DGRL D +L+VN +D+S V H+
Sbjct: 138 NSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHS 197
Query: 243 YAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLV 302
AV L++ V+ L V R Q P + V L K + LG +
Sbjct: 198 RAVEALKEAGPVVRLVVRRRQP--------------PPETIMEVNLLKG--PKGLGFSIA 241
Query: 303 RKVDE---PG---VFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQAS 356
+ PG ++I +++GG A + G+L+ DR+LA+N +L+ E A ++ +
Sbjct: 242 GGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNT 301
Query: 357 ERRVHLVVSRQVRQRSPDIFQEAGWNS------------NGSWS-----------PGPGE 393
V+L V++ D++ + S N S P P +
Sbjct: 302 SDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYPAPPQ 361
Query: 394 RSNT---PKPLH----PTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEP 446
T P P H T + + + K LG + GG E I+V +
Sbjct: 362 VPPTRYSPIPRHMLAEEDFTREPRKIILHKG-STGLGFNIVGG----EDGEGIFVSFILA 416
Query: 447 GGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQE 503
GG G ++ GD +L+V+GV L + +A A LKR S+ + V +Y P+E
Sbjct: 417 GGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTI----VAQYRPEE 469
Score = 69.7 bits (169), Expect = 8e-12
Identities = 63/227 (27%), Positives = 97/227 (42%), Gaps = 45/227 (19%)
Query: 408 HEKVVNIQKDPGESLGMTVAGGAS--HREWDLPIYVISVEPGGVISRDGRIKTGDILLNV 465
+E++V + + G LG ++AGG H D I++ + PGG + DGR+ D +L V
Sbjct: 129 YEEIVLERGNSG--LGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRV 186
Query: 466 DGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSP 525
+ V+++EV S AV LK + L V+ +P PP
Sbjct: 187 NEVDVSEVVHSRAVEALKEAGPVV---RLVVRRRQP-----------------PPE---- 222
Query: 526 SWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGY--EEYNGNKPFFIKSIVEGTPAYN 583
++ L + G LGF I GG + G+ +I I+EG A
Sbjct: 223 -------------TIMEVNLLKGPKG-LGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQK 268
Query: 584 DGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTIVSWPGT 630
DGR++ GD LLAVN + + H LK + L + PG+
Sbjct: 269 DGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAK-PGS 314
Score = 60.1 bits (144), Expect = 6e-09
Identities = 66/281 (23%), Positives = 106/281 (37%), Gaps = 60/281 (21%)
Query: 177 TSIKINRVDPSESLSIRLVGGSETPLV----HIIIQHIYRDGVIARDGRLLPGDIILKVN 232
T +++N + + L + GG + I I I G +DGRL GD +L VN
Sbjct: 223 TIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVN 282
Query: 233 GMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPD----------------- 275
++ +V H AV L+ +++L V + + PD
Sbjct: 283 NTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNS 342
Query: 276 -----------------------AYRP------RDDSF-----HVILNKSSPEEQLGIKL 301
Y P ++ F +IL+K S LG +
Sbjct: 343 SLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTG--LGFNI 400
Query: 302 VRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVH 361
V D G+F+ +L GG A G+L DR+L++NG +LR + E AA ++ + + V
Sbjct: 401 VGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVT 460
Query: 362 LVVSRQVRQRS---PDIFQEAGWNSNGSWSPGPGERSNTPK 399
+V + + S I N S S G G + K
Sbjct: 461 IVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEK 501
Score = 45.1 bits (105), Expect = 2e-04
Identities = 29/90 (32%), Positives = 45/90 (50%), Gaps = 3/90 (3%)
Query: 537 LYNCKDIVLRRNTAGSLGFCIVGGYEEYN--GNKPFFIKSIVEGTPAYNDGRIRCGDILL 594
++ ++IVL R +G LGF I GG + + + FI I+ G A DGR+ D +L
Sbjct: 126 MFKYEEIVLERGNSG-LGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVL 184
Query: 595 AVNGRSTSGMIHACLARLLKELKGRITLTI 624
VN S ++H+ LKE + L +
Sbjct: 185 RVNEVDVSEVVHSRAVEALKEAGPVVRLVV 214
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 103 bits (256), Expect = 6e-22
Identities = 95/335 (28%), Positives = 142/335 (42%), Gaps = 60/335 (17%)
Query: 306 DEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVS 365
D+ +FI ++ GG A + G+L ND +L +N D+R + A ++ + V L V
Sbjct: 249 DDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVK 308
Query: 366 RQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPG-ESLGM 424
R+ KP+ EK++ I+ G + LG
Sbjct: 309 RR-------------------------------KPVS------EKIMEIKLIKGPKGLGF 331
Query: 425 TVAGGAS--HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALL 482
++AGG H D IYV + GG +DG+++ GD LL V+ V L EV+ EAV L
Sbjct: 332 SIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTAL 391
Query: 483 KRTSSSIVLKALEVKE------YEPQEDCSSPAALDSNH---------NMAPPSDWSPSW 527
K TS + LK + Y P + +S + NH A P+ +SP
Sbjct: 392 KNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVS 451
Query: 528 VMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRI 587
L + +VL R + G LGF IVGG + + FI I+ G PA G +
Sbjct: 452 KAVLGDDEITREPRKVVLHRGSTG-LGFNIVGGED----GEGIFISFILAGGPADLSGEL 506
Query: 588 RCGDILLAVNGRSTSGMIHACLARLLKELKGRITL 622
R GD +++VN H A LK +T+
Sbjct: 507 RKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTI 541
Score = 89.7 bits (221), Expect = 7e-18
Identities = 87/357 (24%), Positives = 150/357 (42%), Gaps = 52/357 (14%)
Query: 173 DGEITSIKINRVDPSESLSIRLVGGSETPLV----HIIIQHIYRDGVIARDGRLLPGDII 228
D E I + R + L + GG++ P + I I I G A+DGRL D I
Sbjct: 219 DYEYEEITLER--GNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCI 276
Query: 229 LKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVIL 288
L+VN +D+ +V H+ AV L++ ++ L V R +P + I
Sbjct: 277 LRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRR---------------KPVSEKIMEIK 321
Query: 289 NKSSPEEQLGIKLVRKVDE---PG---VFIFNVLDGGVAYRHGQLEENDRVLAINGHDLR 342
P + LG + V PG +++ +++GG A++ G+L+ D++LA+N L
Sbjct: 322 LIKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLE 380
Query: 343 YGSPESAAHLIQASERRVHLVVSRQVRQ------RSPDIFQEAGWNSNGSWSPGP--GER 394
+ E A ++ + V+L V++ PDI + + SP G+
Sbjct: 381 EVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQT 440
Query: 395 SNTPKPLHPTITCHEKVVNIQKDP--------GESLGMTVAGGASHREWDLPIYVISVEP 446
+P P I ++P LG + GG E I++ +
Sbjct: 441 PASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGG----EDGEGIFISFILA 496
Query: 447 GGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQE 503
GG G ++ GD +++V+ V+L S +A A LK ++ + V +Y P+E
Sbjct: 497 GGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTI----VAQYRPEE 549
Score = 68.6 bits (166), Expect = 2e-11
Identities = 55/207 (26%), Positives = 88/207 (42%), Gaps = 42/207 (20%)
Query: 422 LGMTVAGGAS--HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAV 479
LG ++AGG H D I++ + GG ++DGR++ D +L V+ V++ +V+ S+AV
Sbjct: 234 LGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAV 293
Query: 480 ALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYN 539
LK S + L VK +P +
Sbjct: 294 EALKEAGSIV---RLYVKRRKPVSE----------------------------------K 316
Query: 540 CKDIVLRRNTAGSLGFCIVGGY--EEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVN 597
+I L + G LGF I GG + G+ ++ I+EG A+ DG+++ GD LLAVN
Sbjct: 317 IMEIKLIKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVN 375
Query: 598 GRSTSGMIHACLARLLKELKGRITLTI 624
+ H LK + L +
Sbjct: 376 NVCLEEVTHEEAVTALKNTSDFVYLKV 402
Score = 59.7 bits (143), Expect = 8e-09
Identities = 53/206 (25%), Positives = 83/206 (40%), Gaps = 40/206 (19%)
Query: 205 IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQK 264
I + I G +DG+L GD +L VN + + V H AV L+ ++L V +
Sbjct: 348 IYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTS 407
Query: 265 FRSRNNGQAPDA---------------------------YRP------RDDSF-----HV 286
+ PD Y P DD V
Sbjct: 408 MYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKV 467
Query: 287 ILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSP 346
+L++ S LG +V D G+FI +L GG A G+L + DR++++N DLR S
Sbjct: 468 VLHRGSTG--LGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASH 525
Query: 347 ESAAHLIQASERRVHLVVSRQVRQRS 372
E AA ++ + + V +V + + S
Sbjct: 526 EQAAAALKNAGQAVTIVAQYRPEEYS 551
Score = 45.8 bits (107), Expect = 1e-04
Identities = 29/89 (32%), Positives = 41/89 (46%), Gaps = 3/89 (3%)
Query: 538 YNCKDIVLRRNTAGSLGFCIVGGYEE--YNGNKPFFIKSIVEGTPAYNDGRIRCGDILLA 595
Y ++I L R +G LGF I GG + + FI I+ G A DGR+R D +L
Sbjct: 220 YEYEEITLERGNSG-LGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILR 278
Query: 596 VNGRSTSGMIHACLARLLKELKGRITLTI 624
VN + H+ LKE + L +
Sbjct: 279 VNEVDVRDVTHSKAVEALKEAGSIVRLYV 307
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 103 bits (256), Expect = 6e-22
Identities = 95/335 (28%), Positives = 142/335 (42%), Gaps = 60/335 (17%)
Query: 306 DEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVS 365
D+ +FI ++ GG A + G+L ND +L +N D+R + A ++ + V L V
Sbjct: 249 DDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVK 308
Query: 366 RQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPG-ESLGM 424
R+ KP+ EK++ I+ G + LG
Sbjct: 309 RR-------------------------------KPVS------EKIMEIKLIKGPKGLGF 331
Query: 425 TVAGGAS--HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALL 482
++AGG H D IYV + GG +DG+++ GD LL V+ V L EV+ EAV L
Sbjct: 332 SIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTAL 391
Query: 483 KRTSSSIVLKALEVKE------YEPQEDCSSPAALDSNH---------NMAPPSDWSPSW 527
K TS + LK + Y P + +S + NH A P+ +SP
Sbjct: 392 KNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVS 451
Query: 528 VMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRI 587
L + +VL R + G LGF IVGG + + FI I+ G PA G +
Sbjct: 452 KAVLGDDEITREPRKVVLHRGSTG-LGFNIVGGED----GEGIFISFILAGGPADLSGEL 506
Query: 588 RCGDILLAVNGRSTSGMIHACLARLLKELKGRITL 622
R GD +++VN H A LK +T+
Sbjct: 507 RKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTI 541
Score = 89.7 bits (221), Expect = 7e-18
Identities = 87/357 (24%), Positives = 150/357 (42%), Gaps = 52/357 (14%)
Query: 173 DGEITSIKINRVDPSESLSIRLVGGSETPLV----HIIIQHIYRDGVIARDGRLLPGDII 228
D E I + R + L + GG++ P + I I I G A+DGRL D I
Sbjct: 219 DYEYEEITLER--GNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCI 276
Query: 229 LKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVIL 288
L+VN +D+ +V H+ AV L++ ++ L V R +P + I
Sbjct: 277 LRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRR---------------KPVSEKIMEIK 321
Query: 289 NKSSPEEQLGIKLVRKVDE---PG---VFIFNVLDGGVAYRHGQLEENDRVLAINGHDLR 342
P + LG + V PG +++ +++GG A++ G+L+ D++LA+N L
Sbjct: 322 LIKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLE 380
Query: 343 YGSPESAAHLIQASERRVHLVVSRQVRQ------RSPDIFQEAGWNSNGSWSPGP--GER 394
+ E A ++ + V+L V++ PDI + + SP G+
Sbjct: 381 EVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQT 440
Query: 395 SNTPKPLHPTITCHEKVVNIQKDP--------GESLGMTVAGGASHREWDLPIYVISVEP 446
+P P I ++P LG + GG E I++ +
Sbjct: 441 PASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGG----EDGEGIFISFILA 496
Query: 447 GGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQE 503
GG G ++ GD +++V+ V+L S +A A LK ++ + V +Y P+E
Sbjct: 497 GGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTI----VAQYRPEE 549
Score = 68.6 bits (166), Expect = 2e-11
Identities = 55/207 (26%), Positives = 88/207 (42%), Gaps = 42/207 (20%)
Query: 422 LGMTVAGGAS--HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAV 479
LG ++AGG H D I++ + GG ++DGR++ D +L V+ V++ +V+ S+AV
Sbjct: 234 LGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAV 293
Query: 480 ALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYN 539
LK S + L VK +P +
Sbjct: 294 EALKEAGSIV---RLYVKRRKPVSE----------------------------------K 316
Query: 540 CKDIVLRRNTAGSLGFCIVGGY--EEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVN 597
+I L + G LGF I GG + G+ ++ I+EG A+ DG+++ GD LLAVN
Sbjct: 317 IMEIKLIKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVN 375
Query: 598 GRSTSGMIHACLARLLKELKGRITLTI 624
+ H LK + L +
Sbjct: 376 NVCLEEVTHEEAVTALKNTSDFVYLKV 402
Score = 59.7 bits (143), Expect = 8e-09
Identities = 53/206 (25%), Positives = 83/206 (40%), Gaps = 40/206 (19%)
Query: 205 IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQK 264
I + I G +DG+L GD +L VN + + V H AV L+ ++L V +
Sbjct: 348 IYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTS 407
Query: 265 FRSRNNGQAPDA---------------------------YRP------RDDSF-----HV 286
+ PD Y P DD V
Sbjct: 408 MYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKV 467
Query: 287 ILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSP 346
+L++ S LG +V D G+FI +L GG A G+L + DR++++N DLR S
Sbjct: 468 VLHRGSTG--LGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASH 525
Query: 347 ESAAHLIQASERRVHLVVSRQVRQRS 372
E AA ++ + + V +V + + S
Sbjct: 526 EQAAAALKNAGQAVTIVAQYRPEEYS 551
Score = 45.8 bits (107), Expect = 1e-04
Identities = 29/89 (32%), Positives = 41/89 (46%), Gaps = 3/89 (3%)
Query: 538 YNCKDIVLRRNTAGSLGFCIVGGYEE--YNGNKPFFIKSIVEGTPAYNDGRIRCGDILLA 595
Y ++I L R +G LGF I GG + + FI I+ G A DGR+R D +L
Sbjct: 220 YEYEEITLERGNSG-LGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILR 278
Query: 596 VNGRSTSGMIHACLARLLKELKGRITLTI 624
VN + H+ LKE + L +
Sbjct: 279 VNEVDVRDVTHSKAVEALKEAGSIVRLYV 307
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 101 bits (251), Expect = 2e-21
Identities = 118/491 (24%), Positives = 195/491 (39%), Gaps = 96/491 (19%)
Query: 190 LSIRLVGGS-ETPLVH----IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYA 244
L I + GG TP I I + +G AR G + GD +L+VNG+ + H+ A
Sbjct: 738 LGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHEA 796
Query: 245 VRLLRQPCQVLWLTVMREQKFRSRNNG-----QAPDAYRPRDDSFH----VILNKSSP-- 293
V LR + + V RE+ N + D Y PR+ +L SP
Sbjct: 797 VEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLPPESPGP 856
Query: 294 ------------EEQLGIKLVR-------KVDEPGVFIFNVLDGGVAYRHGQLEENDRVL 334
E LG + + + G+F+ + +GG A+R G L+ DRVL
Sbjct: 857 LRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVL 916
Query: 335 AINGHDLRYGSPESAAHLIQASERRVHLVVSRQ---------VRQRSPDIFQEAGWNSNG 385
+ING D+ + A L+ A+ + L++ R+ + SP A +
Sbjct: 917 SINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITT 976
Query: 386 SWSPGPGERSNTPKPLHPTITCHEKVVNIQ-KDPGESLGMTVAGGASHRE-----WDLPI 439
+ PG S P L + V I+ G LG+++ GG+ H + +
Sbjct: 977 ATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGV 1036
Query: 440 YVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEY 499
++ V P G+ +R G ++ GD +L V+G ++ + + EAV+ L R + L
Sbjct: 1037 FISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLV------ 1089
Query: 500 EPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVG 559
+ APP +++ +++ LG I G
Sbjct: 1090 --------------RRDPAPP------------------GLRELCIQKAPGERLGISIRG 1117
Query: 560 GYEEYNGN------KPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLL 613
G + GN + FI + A DGR+R G LL VN +S G+ H +LL
Sbjct: 1118 GARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLL 1177
Query: 614 KELKGRITLTI 624
+ + +T+ +
Sbjct: 1178 RSVGDTLTVLV 1188
Score = 60.5 bits (145), Expect = 5e-09
Identities = 62/235 (26%), Positives = 99/235 (42%), Gaps = 33/235 (14%)
Query: 409 EKVVNIQKDPGESLGMTVAGGASHREW---DLPIYVISVEPGGVISRDGRIKTGDILLNV 465
E + I + G LG+++AGG + D I++ V G +R G ++ GD LL V
Sbjct: 726 ELTLTILRQTG-GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEV 783
Query: 466 DGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSP 525
+GV L EAV L+ +++ ++ + EP+ + + P D+SP
Sbjct: 784 NGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITP-------LRPEDDYSP 836
Query: 526 SW---------VMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPF------ 570
++ E P L L R+ G LGF I GG G+ P+
Sbjct: 837 RERRGGGLRLPLLPPESPGPLRQRHVACLARSERG-LGFSIAGG----KGSTPYRAGDAG 891
Query: 571 -FIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTI 624
F+ I EG A+ G ++ GD +L++NG + H LL I L +
Sbjct: 892 IFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLL 946
Score = 55.8 bits (133), Expect = 1e-07
Identities = 54/198 (27%), Positives = 77/198 (38%), Gaps = 34/198 (17%)
Query: 161 PEVFPRLYHLIPDGEITSIKINRVDPSESLSIRLVGGSE-------TPLVHIIIQHIYRD 213
P + P L +G +I L + +VGGS+ + I +
Sbjct: 985 PSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPR 1044
Query: 214 GVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQA 273
G+ AR G L GD IL VNG D+ + H AV L +PC L L V R+
Sbjct: 1045 GLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRD----------- 1092
Query: 274 PDAYRPRDDSFHVILNKSSPEEQLGIKL----------VRKVDEPGVFIFNVLDGGVAYR 323
P + + +P E+LGI + R + G+FI V G A R
Sbjct: 1093 -----PAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGR 1147
Query: 324 HGQLEENDRVLAINGHDL 341
G+L R+L +N L
Sbjct: 1148 DGRLRVGLRLLEVNQQSL 1165
Score = 35.0 bits (79), Expect = 0.21
Identities = 26/82 (31%), Positives = 36/82 (43%), Gaps = 8/82 (9%)
Query: 186 PSESLSIRLVGGSETPLVH--------IIIQHIYRDGVIARDGRLLPGDIILKVNGMDIS 237
P E L I + GG+ + I I + G RDGRL G +L+VN +
Sbjct: 1107 PGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLL 1166
Query: 238 NVPHNYAVRLLRQPCQVLWLTV 259
+ H AV+LLR L + V
Sbjct: 1167 GLTHGEAVQLLRSVGDTLTVLV 1188
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 101 bits (251), Expect = 2e-21
Identities = 118/491 (24%), Positives = 195/491 (39%), Gaps = 96/491 (19%)
Query: 190 LSIRLVGGS-ETPLVH----IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYA 244
L I + GG TP I I + +G AR G + GD +L+VNG+ + H+ A
Sbjct: 738 LGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHEA 796
Query: 245 VRLLRQPCQVLWLTVMREQKFRSRNNG-----QAPDAYRPRDDSFH----VILNKSSP-- 293
V LR + + V RE+ N + D Y PR+ +L SP
Sbjct: 797 VEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLPPESPGP 856
Query: 294 ------------EEQLGIKLVR-------KVDEPGVFIFNVLDGGVAYRHGQLEENDRVL 334
E LG + + + G+F+ + +GG A+R G L+ DRVL
Sbjct: 857 LRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVL 916
Query: 335 AINGHDLRYGSPESAAHLIQASERRVHLVVSRQ---------VRQRSPDIFQEAGWNSNG 385
+ING D+ + A L+ A+ + L++ R+ + SP A +
Sbjct: 917 SINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITT 976
Query: 386 SWSPGPGERSNTPKPLHPTITCHEKVVNIQ-KDPGESLGMTVAGGASHRE-----WDLPI 439
+ PG S P L + V I+ G LG+++ GG+ H + +
Sbjct: 977 ATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGV 1036
Query: 440 YVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEY 499
++ V P G+ +R G ++ GD +L V+G ++ + + EAV+ L R + L
Sbjct: 1037 FISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLV------ 1089
Query: 500 EPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVG 559
+ APP +++ +++ LG I G
Sbjct: 1090 --------------RRDPAPP------------------GLRELCIQKAPGERLGISIRG 1117
Query: 560 GYEEYNGN------KPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLL 613
G + GN + FI + A DGR+R G LL VN +S G+ H +LL
Sbjct: 1118 GARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLL 1177
Query: 614 KELKGRITLTI 624
+ + +T+ +
Sbjct: 1178 RSVGDTLTVLV 1188
Score = 60.5 bits (145), Expect = 5e-09
Identities = 62/235 (26%), Positives = 99/235 (42%), Gaps = 33/235 (14%)
Query: 409 EKVVNIQKDPGESLGMTVAGGASHREW---DLPIYVISVEPGGVISRDGRIKTGDILLNV 465
E + I + G LG+++AGG + D I++ V G +R G ++ GD LL V
Sbjct: 726 ELTLTILRQTG-GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEV 783
Query: 466 DGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSP 525
+GV L EAV L+ +++ ++ + EP+ + + P D+SP
Sbjct: 784 NGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITP-------LRPEDDYSP 836
Query: 526 SW---------VMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPF------ 570
++ E P L L R+ G LGF I GG G+ P+
Sbjct: 837 RERRGGGLRLPLLPPESPGPLRQRHVACLARSERG-LGFSIAGG----KGSTPYRAGDAG 891
Query: 571 -FIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTI 624
F+ I EG A+ G ++ GD +L++NG + H LL I L +
Sbjct: 892 IFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLL 946
Score = 55.8 bits (133), Expect = 1e-07
Identities = 54/198 (27%), Positives = 77/198 (38%), Gaps = 34/198 (17%)
Query: 161 PEVFPRLYHLIPDGEITSIKINRVDPSESLSIRLVGGSE-------TPLVHIIIQHIYRD 213
P + P L +G +I L + +VGGS+ + I +
Sbjct: 985 PSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPR 1044
Query: 214 GVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQA 273
G+ AR G L GD IL VNG D+ + H AV L +PC L L V R+
Sbjct: 1045 GLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRD----------- 1092
Query: 274 PDAYRPRDDSFHVILNKSSPEEQLGIKL----------VRKVDEPGVFIFNVLDGGVAYR 323
P + + +P E+LGI + R + G+FI V G A R
Sbjct: 1093 -----PAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGR 1147
Query: 324 HGQLEENDRVLAINGHDL 341
G+L R+L +N L
Sbjct: 1148 DGRLRVGLRLLEVNQQSL 1165
Score = 35.0 bits (79), Expect = 0.21
Identities = 26/82 (31%), Positives = 36/82 (43%), Gaps = 8/82 (9%)
Query: 186 PSESLSIRLVGGSETPLVH--------IIIQHIYRDGVIARDGRLLPGDIILKVNGMDIS 237
P E L I + GG+ + I I + G RDGRL G +L+VN +
Sbjct: 1107 PGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLL 1166
Query: 238 NVPHNYAVRLLRQPCQVLWLTV 259
+ H AV+LLR L + V
Sbjct: 1167 GLTHGEAVQLLRSVGDTLTVLV 1188
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 97.8 bits (242), Expect = 3e-20
Identities = 100/344 (29%), Positives = 144/344 (41%), Gaps = 72/344 (20%)
Query: 306 DEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVS 365
D+P +FI ++ GG A + G+L ND +L +N D+R + +A ++ + V L V
Sbjct: 133 DDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVM 192
Query: 366 RQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPG-ESLGM 424
R R P EKV+ I+ G + LG
Sbjct: 193 R----RKPPA---------------------------------EKVMEIKLIKGPKGLGF 215
Query: 425 TVAGGAS--HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALL 482
++AGG H D IYV + GG +DGR++ GD +L V+ V L +V +AVA L
Sbjct: 216 SIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAAL 275
Query: 483 KRTSSSIVLKALEVK------EYEPQE-------------DCSSPAALDSNHNMAP--PS 521
K T + LK + Y P + SS D M P P
Sbjct: 276 KNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPR 335
Query: 522 DWSPSWVMWL---ELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEG 578
+SP L ++PR + IV+ R + G LGF IVGG + + FI I+ G
Sbjct: 336 RYSPVAKDLLGEEDIPR---EPRRIVIHRGSTG-LGFNIVGGED----GEGIFISFILAG 387
Query: 579 TPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITL 622
PA G +R GD +L+VNG H A LK +T+
Sbjct: 388 GPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTI 431
Score = 89.0 bits (219), Expect = 1e-17
Identities = 87/363 (23%), Positives = 153/363 (42%), Gaps = 56/363 (15%)
Query: 173 DGEITSIKINRVDPSESLSIRLVGGSETPLV----HIIIQHIYRDGVIARDGRLLPGDII 228
+GE+ +I + L + GG++ P + I I I G A+DGRL D I
Sbjct: 101 EGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSI 160
Query: 229 LKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVIL 288
L VN +D+ V H+ AV L++ ++ L VMR + P + + L
Sbjct: 161 LFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKP--------------PAEKVMEIKL 206
Query: 289 NKSSPEEQLGIKLVRKVDE---PG---VFIFNVLDGGVAYRHGQLEENDRVLAINGHDLR 342
K + LG + V PG +++ +++GG A++ G+L+ D++LA+N L
Sbjct: 207 IKG--PKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLE 264
Query: 343 YGSPESAAHLIQASERRVHLVVSRQVR------QRSPDIFQEAGWNSNGSWSPGPGERSN 396
E A ++ + V+L V++ PDI + + S ++
Sbjct: 265 DVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTD 324
Query: 397 TPKPLHPTITCHEKVV--------NIQKDP--------GESLGMTVAGGASHREWDLPIY 440
P + PT V +I ++P LG + GG E I+
Sbjct: 325 YPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGG----EDGEGIF 380
Query: 441 VISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYE 500
+ + GG G ++ GD +L+V+GV+L S +A LK ++ + + +Y+
Sbjct: 381 ISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTI----IAQYK 436
Query: 501 PQE 503
P+E
Sbjct: 437 PEE 439
Score = 73.9 bits (180), Expect = 4e-13
Identities = 58/215 (26%), Positives = 92/215 (42%), Gaps = 42/215 (19%)
Query: 422 LGMTVAGGAS--HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAV 479
LG ++AGG H D I++ + PGG ++DGR++ D +L V+ V++ EV+ S AV
Sbjct: 118 LGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAV 177
Query: 480 ALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYN 539
LK S + L + K PP++
Sbjct: 178 EALKEAGSIVRLYVMRRK---------------------PPAE----------------K 200
Query: 540 CKDIVLRRNTAGSLGFCIVGGY--EEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVN 597
+I L + G LGF I GG + G+ ++ I+EG A+ DGR++ GD +LAVN
Sbjct: 201 VMEIKLIKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVN 259
Query: 598 GRSTSGMIHACLARLLKELKGRITLTIVSWPGTFL 632
++H LK + L + +L
Sbjct: 260 SVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYL 294
Score = 62.4 bits (150), Expect = 1e-09
Identities = 54/216 (25%), Positives = 85/216 (39%), Gaps = 54/216 (25%)
Query: 205 IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQK 264
I + I G +DGRL GD IL VN + + +V H AV L+ V++L V +
Sbjct: 232 IYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKP-- 289
Query: 265 FRSRNNGQAPDAYRPRD--------------------DSFHVILNKSSPEEQ-------- 296
+N D+Y P D + + +SP
Sbjct: 290 ----SNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLL 345
Query: 297 --------------------LGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAI 336
LG +V D G+FI +L GG A G+L + D++L++
Sbjct: 346 GEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSV 405
Query: 337 NGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRS 372
NG DLR S E AA ++ + + V ++ + + S
Sbjct: 406 NGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYS 441
Score = 45.4 bits (106), Expect = 2e-04
Identities = 30/87 (34%), Positives = 44/87 (50%), Gaps = 3/87 (3%)
Query: 541 KDIVLRRNTAGSLGFCIVGGYEE-YNGNKP-FFIKSIVEGTPAYNDGRIRCGDILLAVNG 598
++I L R +G LGF I GG + + G+ P FI I+ G A DGR+R D +L VN
Sbjct: 107 EEITLERGNSG-LGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNE 165
Query: 599 RSTSGMIHACLARLLKELKGRITLTIV 625
+ H+ LKE + L ++
Sbjct: 166 VDVREVTHSAAVEALKEAGSIVRLYVM 192
Score = 38.1 bits (87), Expect = 0.025
Identities = 27/89 (30%), Positives = 37/89 (41%), Gaps = 2/89 (2%)
Query: 187 SESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVR 246
S L +VGG + I I I G G L GD IL VNG+D+ N H A
Sbjct: 363 STGLGFNIVGGEDGE--GIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAI 420
Query: 247 LLRQPCQVLWLTVMREQKFRSRNNGQAPD 275
L+ Q + + + + SR + D
Sbjct: 421 ALKNAGQTVTIIAQYKPEEYSRFEAKIHD 449
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 97.8 bits (242), Expect = 3e-20
Identities = 100/344 (29%), Positives = 144/344 (41%), Gaps = 72/344 (20%)
Query: 306 DEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVS 365
D+P +FI ++ GG A + G+L ND +L +N D+R + +A ++ + V L V
Sbjct: 87 DDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVM 146
Query: 366 RQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPG-ESLGM 424
R R P EKV+ I+ G + LG
Sbjct: 147 R----RKPPA---------------------------------EKVMEIKLIKGPKGLGF 169
Query: 425 TVAGGAS--HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALL 482
++AGG H D IYV + GG +DGR++ GD +L V+ V L +V +AVA L
Sbjct: 170 SIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAAL 229
Query: 483 KRTSSSIVLKALEVK------EYEPQE-------------DCSSPAALDSNHNMAP--PS 521
K T + LK + Y P + SS D M P P
Sbjct: 230 KNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPR 289
Query: 522 DWSPSWVMWL---ELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEG 578
+SP L ++PR + IV+ R + G LGF IVGG + + FI I+ G
Sbjct: 290 RYSPVAKDLLGEEDIPR---EPRRIVIHRGSTG-LGFNIVGGED----GEGIFISFILAG 341
Query: 579 TPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITL 622
PA G +R GD +L+VNG H A LK +T+
Sbjct: 342 GPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTI 385
Score = 89.0 bits (219), Expect = 1e-17
Identities = 87/363 (23%), Positives = 153/363 (42%), Gaps = 56/363 (15%)
Query: 173 DGEITSIKINRVDPSESLSIRLVGGSETPLV----HIIIQHIYRDGVIARDGRLLPGDII 228
+GE+ +I + L + GG++ P + I I I G A+DGRL D I
Sbjct: 55 EGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSI 114
Query: 229 LKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVIL 288
L VN +D+ V H+ AV L++ ++ L VMR + P + + L
Sbjct: 115 LFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKP--------------PAEKVMEIKL 160
Query: 289 NKSSPEEQLGIKLVRKVDE---PG---VFIFNVLDGGVAYRHGQLEENDRVLAINGHDLR 342
K + LG + V PG +++ +++GG A++ G+L+ D++LA+N L
Sbjct: 161 IKG--PKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLE 218
Query: 343 YGSPESAAHLIQASERRVHLVVSRQVR------QRSPDIFQEAGWNSNGSWSPGPGERSN 396
E A ++ + V+L V++ PDI + + S ++
Sbjct: 219 DVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTD 278
Query: 397 TPKPLHPTITCHEKVV--------NIQKDP--------GESLGMTVAGGASHREWDLPIY 440
P + PT V +I ++P LG + GG E I+
Sbjct: 279 YPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGG----EDGEGIF 334
Query: 441 VISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYE 500
+ + GG G ++ GD +L+V+GV+L S +A LK ++ + + +Y+
Sbjct: 335 ISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTI----IAQYK 390
Query: 501 PQE 503
P+E
Sbjct: 391 PEE 393
Score = 73.9 bits (180), Expect = 4e-13
Identities = 58/215 (26%), Positives = 92/215 (42%), Gaps = 42/215 (19%)
Query: 422 LGMTVAGGAS--HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAV 479
LG ++AGG H D I++ + PGG ++DGR++ D +L V+ V++ EV+ S AV
Sbjct: 72 LGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAV 131
Query: 480 ALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYN 539
LK S + L + K PP++
Sbjct: 132 EALKEAGSIVRLYVMRRK---------------------PPAE----------------K 154
Query: 540 CKDIVLRRNTAGSLGFCIVGGY--EEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVN 597
+I L + G LGF I GG + G+ ++ I+EG A+ DGR++ GD +LAVN
Sbjct: 155 VMEIKLIKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVN 213
Query: 598 GRSTSGMIHACLARLLKELKGRITLTIVSWPGTFL 632
++H LK + L + +L
Sbjct: 214 SVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYL 248
Score = 62.4 bits (150), Expect = 1e-09
Identities = 54/216 (25%), Positives = 85/216 (39%), Gaps = 54/216 (25%)
Query: 205 IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQK 264
I + I G +DGRL GD IL VN + + +V H AV L+ V++L V +
Sbjct: 186 IYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKP-- 243
Query: 265 FRSRNNGQAPDAYRPRD--------------------DSFHVILNKSSPEEQ-------- 296
+N D+Y P D + + +SP
Sbjct: 244 ----SNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLL 299
Query: 297 --------------------LGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAI 336
LG +V D G+FI +L GG A G+L + D++L++
Sbjct: 300 GEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSV 359
Query: 337 NGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRS 372
NG DLR S E AA ++ + + V ++ + + S
Sbjct: 360 NGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYS 395
Score = 45.4 bits (106), Expect = 2e-04
Identities = 30/87 (34%), Positives = 44/87 (50%), Gaps = 3/87 (3%)
Query: 541 KDIVLRRNTAGSLGFCIVGGYEE-YNGNKP-FFIKSIVEGTPAYNDGRIRCGDILLAVNG 598
++I L R +G LGF I GG + + G+ P FI I+ G A DGR+R D +L VN
Sbjct: 61 EEITLERGNSG-LGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNE 119
Query: 599 RSTSGMIHACLARLLKELKGRITLTIV 625
+ H+ LKE + L ++
Sbjct: 120 VDVREVTHSAAVEALKEAGSIVRLYVM 146
Score = 38.1 bits (87), Expect = 0.025
Identities = 27/89 (30%), Positives = 37/89 (41%), Gaps = 2/89 (2%)
Query: 187 SESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVR 246
S L +VGG + I I I G G L GD IL VNG+D+ N H A
Sbjct: 317 STGLGFNIVGGEDGE--GIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAI 374
Query: 247 LLRQPCQVLWLTVMREQKFRSRNNGQAPD 275
L+ Q + + + + SR + D
Sbjct: 375 ALKNAGQTVTIIAQYKPEEYSRFEAKIHD 403
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 94.7 bits (234), Expect = 2e-19
Identities = 97/363 (26%), Positives = 146/363 (40%), Gaps = 87/363 (23%)
Query: 306 DEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVS 365
D+PG+FI ++ GG A G+L ND +L +N D+ S A ++ + V L V
Sbjct: 72 DDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVR 131
Query: 366 RQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMT 425
R+ +P+ T+ + + K P + LG +
Sbjct: 132 RR-------------------------------RPILETVV----EIKLFKGP-KGLGFS 155
Query: 426 VAGGAS--HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLK 483
+AGG H D IYV + GG +DGR++ GD LL V+ L EV+ EAVA+LK
Sbjct: 156 IAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILK 215
Query: 484 RTSSSIVLKALE------VKEYEPQEDCSSPAALDSNHNMA---------------PPSD 522
TS + LK + Y P + S + NH ++ P
Sbjct: 216 NTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGR 275
Query: 523 WSPSWVMWL--------------------ELPRCLY---NCKDIVLRRNTAGSLGFCIVG 559
+SP L L R + + +VL + + G LGF IVG
Sbjct: 276 YSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTG-LGFNIVG 334
Query: 560 GYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGR 619
G + + F+ I+ G PA G ++ GD +L+VNG G H A LK
Sbjct: 335 GED----GEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQT 390
Query: 620 ITL 622
+T+
Sbjct: 391 VTI 393
Score = 90.9 bits (224), Expect = 3e-18
Identities = 97/396 (24%), Positives = 163/396 (41%), Gaps = 85/396 (21%)
Query: 187 SESLSIRLVGGSETPLVH----IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHN 242
+ L + GG++ P + I I I G A DGRL D IL+VN +D+S V H+
Sbjct: 54 NSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHS 113
Query: 243 YAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLV 302
AV L++ ++ L V R RP ++ I P+ LG +
Sbjct: 114 KAVEALKEAGSIVRLYVRRR---------------RPILETVVEIKLFKGPKG-LGFSIA 157
Query: 303 RKVDE---PG---VFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQAS 356
V PG +++ ++DGG A + G+L+ DR+L +N + L + E A +++ +
Sbjct: 158 GGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNT 217
Query: 357 ERRVHLVVSRQ--------------VRQRSPDIFQEAGWNSNG------SWSP-GPGERS 395
V+L V + SP + +NG S P PG S
Sbjct: 218 SEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYS 277
Query: 396 NTPKPL-----------HPTITCH-----EKVVNIQKDP--------GESLGMTVAGGAS 431
PK + H T T ++ V+++ +P LG + GG
Sbjct: 278 PIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGG-- 335
Query: 432 HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVL 491
E I+V + GG G ++ GD +L+V+G++L S +A A LK ++ +
Sbjct: 336 --EDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTI 393
Query: 492 KALEVKEYEPQEDCSSPAALDS------NHNMAPPS 521
+ +Y+P++ A + NH+M+ S
Sbjct: 394 ----IAQYQPEDYARFEAKIHDLREQMMNHSMSSGS 425
Score = 72.0 bits (175), Expect = 2e-12
Identities = 58/207 (28%), Positives = 88/207 (42%), Gaps = 42/207 (20%)
Query: 422 LGMTVAGGAS--HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAV 479
LG ++AGG H D I++ + PGG + DGR++ D +L V+ V+++EVS S+AV
Sbjct: 57 LGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAV 116
Query: 480 ALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYN 539
LK S + L V+ P L
Sbjct: 117 EALKEAGSIV---RLYVRRRRP----------------------------------ILET 139
Query: 540 CKDIVLRRNTAGSLGFCIVGGY--EEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVN 597
+I L + G LGF I GG + G+ ++ I++G A DGR++ GD LL VN
Sbjct: 140 VVEIKLFKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVN 198
Query: 598 GRSTSGMIHACLARLLKELKGRITLTI 624
S + H +LK + L +
Sbjct: 199 NYSLEEVTHEEAVAILKNTSEVVYLKV 225
Score = 48.1 bits (113), Expect = 2e-05
Identities = 32/89 (35%), Positives = 45/89 (50%), Gaps = 3/89 (3%)
Query: 538 YNCKDIVLRRNTAGSLGFCIVGGYEE-YNGNKP-FFIKSIVEGTPAYNDGRIRCGDILLA 595
Y ++I L R +G LGF I GG + + G+ P FI I+ G A DGR+R D +L
Sbjct: 43 YEFEEITLERGNSG-LGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILR 101
Query: 596 VNGRSTSGMIHACLARLLKELKGRITLTI 624
VN S + H+ LKE + L +
Sbjct: 102 VNEVDVSEVSHSKAVEALKEAGSIVRLYV 130
>gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo
sapiens]
Length = 1287
Score = 92.0 bits (227), Expect = 1e-18
Identities = 102/379 (26%), Positives = 159/379 (41%), Gaps = 68/379 (17%)
Query: 307 EPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSR 366
+PG+FI +++ GG A + ++ ++LA+N L + A +IQ S + L++S+
Sbjct: 778 DPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELIISQ 837
Query: 367 Q--VRQRSPDIFQEAGWNSNGS-------------------------------------- 386
V +PD + + NS S
Sbjct: 838 SKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSHTQDQDRNTEELDMAGVQSLVPR 897
Query: 387 ------WSPGPGERSNTPKPLHPTITCHE-KVVNIQKDPGESLGMTVAGGASHREWDLPI 439
+ P G S+ P P P I+ E V + K+ G +LG +V GG + I
Sbjct: 898 LRHQLSFLPLKGAGSSCP-PSPPEISAGEIYFVELVKEDG-TLGFSVTGGINTSVPYGGI 955
Query: 440 YVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEY 499
YV S+ PGG +++G+I GD LL VDGV L ++ +AV L + L ++
Sbjct: 956 YVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQ---VARLVLERR 1012
Query: 500 EPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDI-------VLRRNTAGS 552
P+ P+A DS D + + LP +C + V + A
Sbjct: 1013 VPRSTQQCPSANDSM------GDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANG 1066
Query: 553 LGFCIVGGYEE---YNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACL 609
LGF V +E + + IK + G PA +G I GDI+LAVNGRST G+I +
Sbjct: 1067 LGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEV 1126
Query: 610 ARLLKELKGRITLTIVSWP 628
LL+ +TL + P
Sbjct: 1127 LHLLRGAPQEVTLLLCRPP 1145
Score = 55.8 bits (133), Expect = 1e-07
Identities = 69/291 (23%), Positives = 112/291 (38%), Gaps = 58/291 (19%)
Query: 141 GSAVANHADQGRENSENTTA--PEVFPRLYHL-------------------IPDGEITSI 179
GS +++ DQ R E A + PRL H I GEI +
Sbjct: 870 GSLLSHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFV 929
Query: 180 KINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNV 239
++ + D + S+ + P I ++ I G A++G++L GD +L+V+G+ + +
Sbjct: 930 ELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGL 989
Query: 240 PHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDS---------------- 283
H AV+ L P QV L + R R+ Q P A D
Sbjct: 990 THKQAVQCLTGPGQVARLVLERRVP---RSTQQCPSANDSMGDERTAVSLVTALPGRPSS 1046
Query: 284 ---------FHVILNKSSPEEQLGIKLVRKVDEPG-------VFIFNVLDGGVAYRHGQL 327
F V L K++ LG V+ E V I + G A +G +
Sbjct: 1047 CVSVTDGPKFEVKLKKNA--NGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAI 1104
Query: 328 EENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQE 378
D +LA+NG + HL++ + + V L++ R P++ QE
Sbjct: 1105 AAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPELEQE 1155
Score = 44.7 bits (104), Expect = 3e-04
Identities = 56/241 (23%), Positives = 93/241 (38%), Gaps = 49/241 (20%)
Query: 412 VNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELT 471
V +++DP G + G + D I++ S+ PGG + IK G +L ++ + L
Sbjct: 754 VTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLE 813
Query: 472 EVSRSEAVALLKRTSSSIVL---KALEVKEYEPQEDCSSPA------------------- 509
+ + AV +++ + +I L ++ V P E+ +S A
Sbjct: 814 GFTFNMAVRMIQNSPDNIELIISQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLL 873
Query: 510 --ALDSNHN-----MAPPSDWSP---SWVMWLELPRCLYNCK--------------DIVL 545
D + N MA P + +L L +C ++V
Sbjct: 874 SHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVK 933
Query: 546 RRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMI 605
T G F + GG ++KSIV G PA +G+I GD LL V+G G+
Sbjct: 934 EDGTLG---FSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLT 990
Query: 606 H 606
H
Sbjct: 991 H 991
Score = 35.8 bits (81), Expect = 0.12
Identities = 24/82 (29%), Positives = 35/82 (42%)
Query: 543 IVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTS 602
+ L+R+ GF I G + FI SI+ G PA I+ G +LA+N S
Sbjct: 754 VTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLE 813
Query: 603 GMIHACLARLLKELKGRITLTI 624
G R+++ I L I
Sbjct: 814 GFTFNMAVRMIQNSPDNIELII 835
>gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo
sapiens]
Length = 1309
Score = 92.0 bits (227), Expect = 1e-18
Identities = 102/379 (26%), Positives = 159/379 (41%), Gaps = 68/379 (17%)
Query: 307 EPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSR 366
+PG+FI +++ GG A + ++ ++LA+N L + A +IQ S + L++S+
Sbjct: 800 DPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELIISQ 859
Query: 367 Q--VRQRSPDIFQEAGWNSNGS-------------------------------------- 386
V +PD + + NS S
Sbjct: 860 SKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSHTQDQDRNTEELDMAGVQSLVPR 919
Query: 387 ------WSPGPGERSNTPKPLHPTITCHE-KVVNIQKDPGESLGMTVAGGASHREWDLPI 439
+ P G S+ P P P I+ E V + K+ G +LG +V GG + I
Sbjct: 920 LRHQLSFLPLKGAGSSCP-PSPPEISAGEIYFVELVKEDG-TLGFSVTGGINTSVPYGGI 977
Query: 440 YVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEY 499
YV S+ PGG +++G+I GD LL VDGV L ++ +AV L + L ++
Sbjct: 978 YVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQ---VARLVLERR 1034
Query: 500 EPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDI-------VLRRNTAGS 552
P+ P+A DS D + + LP +C + V + A
Sbjct: 1035 VPRSTQQCPSANDSM------GDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANG 1088
Query: 553 LGFCIVGGYEE---YNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACL 609
LGF V +E + + IK + G PA +G I GDI+LAVNGRST G+I +
Sbjct: 1089 LGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEV 1148
Query: 610 ARLLKELKGRITLTIVSWP 628
LL+ +TL + P
Sbjct: 1149 LHLLRGAPQEVTLLLCRPP 1167
Score = 55.8 bits (133), Expect = 1e-07
Identities = 69/291 (23%), Positives = 112/291 (38%), Gaps = 58/291 (19%)
Query: 141 GSAVANHADQGRENSENTTA--PEVFPRLYHL-------------------IPDGEITSI 179
GS +++ DQ R E A + PRL H I GEI +
Sbjct: 892 GSLLSHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFV 951
Query: 180 KINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNV 239
++ + D + S+ + P I ++ I G A++G++L GD +L+V+G+ + +
Sbjct: 952 ELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGL 1011
Query: 240 PHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDS---------------- 283
H AV+ L P QV L + R R+ Q P A D
Sbjct: 1012 THKQAVQCLTGPGQVARLVLERRVP---RSTQQCPSANDSMGDERTAVSLVTALPGRPSS 1068
Query: 284 ---------FHVILNKSSPEEQLGIKLVRKVDEPG-------VFIFNVLDGGVAYRHGQL 327
F V L K++ LG V+ E V I + G A +G +
Sbjct: 1069 CVSVTDGPKFEVKLKKNA--NGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAI 1126
Query: 328 EENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQE 378
D +LA+NG + HL++ + + V L++ R P++ QE
Sbjct: 1127 AAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPELEQE 1177
Score = 44.7 bits (104), Expect = 3e-04
Identities = 56/241 (23%), Positives = 93/241 (38%), Gaps = 49/241 (20%)
Query: 412 VNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELT 471
V +++DP G + G + D I++ S+ PGG + IK G +L ++ + L
Sbjct: 776 VTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLE 835
Query: 472 EVSRSEAVALLKRTSSSIVL---KALEVKEYEPQEDCSSPA------------------- 509
+ + AV +++ + +I L ++ V P E+ +S A
Sbjct: 836 GFTFNMAVRMIQNSPDNIELIISQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLL 895
Query: 510 --ALDSNHN-----MAPPSDWSP---SWVMWLELPRCLYNCK--------------DIVL 545
D + N MA P + +L L +C ++V
Sbjct: 896 SHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVK 955
Query: 546 RRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMI 605
T G F + GG ++KSIV G PA +G+I GD LL V+G G+
Sbjct: 956 EDGTLG---FSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLT 1012
Query: 606 H 606
H
Sbjct: 1013 H 1013
Score = 35.8 bits (81), Expect = 0.12
Identities = 24/82 (29%), Positives = 35/82 (42%)
Query: 543 IVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTS 602
+ L+R+ GF I G + FI SI+ G PA I+ G +LA+N S
Sbjct: 776 VTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLE 835
Query: 603 GMIHACLARLLKELKGRITLTI 624
G R+++ I L I
Sbjct: 836 GFTFNMAVRMIQNSPDNIELII 857
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 83.6 bits (205), Expect = 5e-16
Identities = 63/219 (28%), Positives = 96/219 (43%), Gaps = 41/219 (18%)
Query: 306 DEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVS 365
D+PG+FI ++ GG A G+L ND +L +N D+ S A ++ + V L V
Sbjct: 228 DDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVR 287
Query: 366 RQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMT 425
R+ +P+ T+ + + K P + LG +
Sbjct: 288 RR-------------------------------RPILETVV----EIKLFKGP-KGLGFS 311
Query: 426 VAGGAS--HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLK 483
+AGG H D IYV + GG +DGR++ GD LL V+ L EV+ EAVA+LK
Sbjct: 312 IAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILK 371
Query: 484 RTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSD 522
TS + LK + + P D H+ +PP +
Sbjct: 372 NTSEVVYLKVGKPTTIYMTDPYGPP---DITHSYSPPME 407
Score = 72.0 bits (175), Expect = 2e-12
Identities = 58/207 (28%), Positives = 88/207 (42%), Gaps = 42/207 (20%)
Query: 422 LGMTVAGGAS--HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAV 479
LG ++AGG H D I++ + PGG + DGR++ D +L V+ V+++EVS S+AV
Sbjct: 213 LGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAV 272
Query: 480 ALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYN 539
LK S + L V+ P L
Sbjct: 273 EALKEAGSIV---RLYVRRRRP----------------------------------ILET 295
Query: 540 CKDIVLRRNTAGSLGFCIVGGY--EEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVN 597
+I L + G LGF I GG + G+ ++ I++G A DGR++ GD LL VN
Sbjct: 296 VVEIKLFKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVN 354
Query: 598 GRSTSGMIHACLARLLKELKGRITLTI 624
S + H +LK + L +
Sbjct: 355 NYSLEEVTHEEAVAILKNTSEVVYLKV 381
Score = 68.9 bits (167), Expect = 1e-11
Identities = 59/220 (26%), Positives = 98/220 (44%), Gaps = 28/220 (12%)
Query: 157 NTTAPEVFPRLYHLIPDGEITSIKINRVDPSESLSIRLVGGSETPLVH----IIIQHIYR 212
NT + P + + E I + R + L + GG++ P + I I I
Sbjct: 182 NTDTLDTIPYVNGTEIEYEFEEITLER--GNSGLGFSIAGGTDNPHIGDDPGIFITKIIP 239
Query: 213 DGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQ 272
G A DGRL D IL+VN +D+S V H+ AV L++ ++ L V R
Sbjct: 240 GGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRR---------- 289
Query: 273 APDAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDE---PG---VFIFNVLDGGVAYRHGQ 326
RP ++ I P+ LG + V PG +++ ++DGG A + G+
Sbjct: 290 -----RPILETVVEIKLFKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGR 343
Query: 327 LEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSR 366
L+ DR+L +N + L + E A +++ + V+L V +
Sbjct: 344 LQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGK 383
Score = 54.3 bits (129), Expect = 3e-07
Identities = 75/360 (20%), Positives = 135/360 (37%), Gaps = 36/360 (10%)
Query: 177 TSIKINRVDPSESLSIRLVGGSETPLV----HIIIQHIYRDGVIARDGRLLPGDIILKVN 232
T ++I + L + GG + I + I G +DGRL GD +L VN
Sbjct: 295 TVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVN 354
Query: 233 GMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPD---AYRPRDDSFHVILN 289
+ V H AV +L+ +V++L V + + PD +Y P ++ + N
Sbjct: 355 NYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGN 414
Query: 290 KSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESA 349
+ E + + + + ++D + L R+ SP
Sbjct: 415 NGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVEC 474
Query: 350 --AHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITC 407
+ L+ A HL + ++ S+ S + S T +
Sbjct: 475 DKSFLLSAPYSHYHL-----------GLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGE 523
Query: 408 HEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDG 467
KVV + G LG + GG I+V + GG G ++ GD +L+V+G
Sbjct: 524 PRKVVLHKGSTG--LGFNIVGGEDGEG----IFVSFILAGGPADLSGELQRGDQILSVNG 577
Query: 468 VELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDS------NHNMAPPS 521
++L S +A A LK ++ + + +Y+P++ A + NH+M+ S
Sbjct: 578 IDLRGASHEQAAAALKGAGQTVTI----IAQYQPEDYARFEAKIHDLREQMMNHSMSSGS 633
Score = 48.1 bits (113), Expect = 2e-05
Identities = 32/89 (35%), Positives = 45/89 (50%), Gaps = 3/89 (3%)
Query: 538 YNCKDIVLRRNTAGSLGFCIVGGYEE-YNGNKP-FFIKSIVEGTPAYNDGRIRCGDILLA 595
Y ++I L R +G LGF I GG + + G+ P FI I+ G A DGR+R D +L
Sbjct: 199 YEFEEITLERGNSG-LGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILR 257
Query: 596 VNGRSTSGMIHACLARLLKELKGRITLTI 624
VN S + H+ LKE + L +
Sbjct: 258 VNEVDVSEVSHSKAVEALKEAGSIVRLYV 286
Score = 42.4 bits (98), Expect = 0.001
Identities = 28/82 (34%), Positives = 42/82 (51%), Gaps = 5/82 (6%)
Query: 541 KDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRS 600
+ +VL + + G LGF IVGG + + F+ I+ G PA G ++ GD +L+VNG
Sbjct: 525 RKVVLHKGSTG-LGFNIVGGED----GEGIFVSFILAGGPADLSGELQRGDQILSVNGID 579
Query: 601 TSGMIHACLARLLKELKGRITL 622
G H A LK +T+
Sbjct: 580 LRGASHEQAAAALKGAGQTVTI 601
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 83.6 bits (205), Expect = 5e-16
Identities = 63/219 (28%), Positives = 96/219 (43%), Gaps = 41/219 (18%)
Query: 306 DEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVS 365
D+PG+FI ++ GG A G+L ND +L +N D+ S A ++ + V L V
Sbjct: 123 DDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVR 182
Query: 366 RQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMT 425
R+ +P+ T+ + + K P + LG +
Sbjct: 183 RR-------------------------------RPILETVV----EIKLFKGP-KGLGFS 206
Query: 426 VAGGAS--HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLK 483
+AGG H D IYV + GG +DGR++ GD LL V+ L EV+ EAVA+LK
Sbjct: 207 IAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILK 266
Query: 484 RTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSD 522
TS + LK + + P D H+ +PP +
Sbjct: 267 NTSEVVYLKVGKPTTIYMTDPYGPP---DITHSYSPPME 302
Score = 72.0 bits (175), Expect = 2e-12
Identities = 58/207 (28%), Positives = 88/207 (42%), Gaps = 42/207 (20%)
Query: 422 LGMTVAGGAS--HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAV 479
LG ++AGG H D I++ + PGG + DGR++ D +L V+ V+++EVS S+AV
Sbjct: 108 LGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAV 167
Query: 480 ALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYN 539
LK S + L V+ P L
Sbjct: 168 EALKEAGSIV---RLYVRRRRP----------------------------------ILET 190
Query: 540 CKDIVLRRNTAGSLGFCIVGGY--EEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVN 597
+I L + G LGF I GG + G+ ++ I++G A DGR++ GD LL VN
Sbjct: 191 VVEIKLFKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVN 249
Query: 598 GRSTSGMIHACLARLLKELKGRITLTI 624
S + H +LK + L +
Sbjct: 250 NYSLEEVTHEEAVAILKNTSEVVYLKV 276
Score = 68.9 bits (167), Expect = 1e-11
Identities = 59/220 (26%), Positives = 98/220 (44%), Gaps = 28/220 (12%)
Query: 157 NTTAPEVFPRLYHLIPDGEITSIKINRVDPSESLSIRLVGGSETPLVH----IIIQHIYR 212
NT + P + + E I + R + L + GG++ P + I I I
Sbjct: 77 NTDTLDTIPYVNGTEIEYEFEEITLER--GNSGLGFSIAGGTDNPHIGDDPGIFITKIIP 134
Query: 213 DGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQ 272
G A DGRL D IL+VN +D+S V H+ AV L++ ++ L V R
Sbjct: 135 GGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRR---------- 184
Query: 273 APDAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDE---PG---VFIFNVLDGGVAYRHGQ 326
RP ++ I P+ LG + V PG +++ ++DGG A + G+
Sbjct: 185 -----RPILETVVEIKLFKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGR 238
Query: 327 LEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSR 366
L+ DR+L +N + L + E A +++ + V+L V +
Sbjct: 239 LQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGK 278
Score = 54.3 bits (129), Expect = 3e-07
Identities = 75/360 (20%), Positives = 135/360 (37%), Gaps = 36/360 (10%)
Query: 177 TSIKINRVDPSESLSIRLVGGSETPLV----HIIIQHIYRDGVIARDGRLLPGDIILKVN 232
T ++I + L + GG + I + I G +DGRL GD +L VN
Sbjct: 190 TVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVN 249
Query: 233 GMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPD---AYRPRDDSFHVILN 289
+ V H AV +L+ +V++L V + + PD +Y P ++ + N
Sbjct: 250 NYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGN 309
Query: 290 KSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESA 349
+ E + + + + ++D + L R+ SP
Sbjct: 310 NGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVEC 369
Query: 350 --AHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITC 407
+ L+ A HL + ++ S+ S + S T +
Sbjct: 370 DKSFLLSAPYSHYHL-----------GLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGE 418
Query: 408 HEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDG 467
KVV + G LG + GG I+V + GG G ++ GD +L+V+G
Sbjct: 419 PRKVVLHKGSTG--LGFNIVGGEDGEG----IFVSFILAGGPADLSGELQRGDQILSVNG 472
Query: 468 VELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDS------NHNMAPPS 521
++L S +A A LK ++ + + +Y+P++ A + NH+M+ S
Sbjct: 473 IDLRGASHEQAAAALKGAGQTVTI----IAQYQPEDYARFEAKIHDLREQMMNHSMSSGS 528
Score = 48.1 bits (113), Expect = 2e-05
Identities = 32/89 (35%), Positives = 45/89 (50%), Gaps = 3/89 (3%)
Query: 538 YNCKDIVLRRNTAGSLGFCIVGGYEE-YNGNKP-FFIKSIVEGTPAYNDGRIRCGDILLA 595
Y ++I L R +G LGF I GG + + G+ P FI I+ G A DGR+R D +L
Sbjct: 94 YEFEEITLERGNSG-LGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILR 152
Query: 596 VNGRSTSGMIHACLARLLKELKGRITLTI 624
VN S + H+ LKE + L +
Sbjct: 153 VNEVDVSEVSHSKAVEALKEAGSIVRLYV 181
Score = 42.4 bits (98), Expect = 0.001
Identities = 28/82 (34%), Positives = 42/82 (51%), Gaps = 5/82 (6%)
Query: 541 KDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRS 600
+ +VL + + G LGF IVGG + + F+ I+ G PA G ++ GD +L+VNG
Sbjct: 420 RKVVLHKGSTG-LGFNIVGGED----GEGIFVSFILAGGPADLSGELQRGDQILSVNGID 474
Query: 601 TSGMIHACLARLLKELKGRITL 622
G H A LK +T+
Sbjct: 475 LRGASHEQAAAALKGAGQTVTI 496
>gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]
Length = 1356
Score = 80.9 bits (198), Expect = 3e-15
Identities = 91/357 (25%), Positives = 141/357 (39%), Gaps = 66/357 (18%)
Query: 309 GVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERR----VHLVV 364
G+ + + GG A END ++ IN DLR E A H+ + + R H+V
Sbjct: 300 GLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVP 359
Query: 365 S------RQVRQRSPDIFQEAGWNSNGSW-------SPGPGERSNTPKPLHPT--ITCHE 409
+ Q+ Q + + + ++ + + S G P+ HP I H
Sbjct: 360 AANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAPRLNHPPEQIDSHS 419
Query: 410 KV--------------------------------------VNIQKDPG-ESLGMTVAGGA 430
++ +NIQ G E LG ++
Sbjct: 420 RLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRD 479
Query: 431 SHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIV 490
PIYV ++ P G +DGR+K GD L+ V+GV+L S+ E V+LL+ T
Sbjct: 480 VTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGT 539
Query: 491 LKALEVKEYEPQEDCSSPAALDSN-HNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNT 549
+ L + QED P L++ M P + + P + N
Sbjct: 540 VSLLVFR----QEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLND 595
Query: 550 AGS--LGFCIVGG-YEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSG 603
+GS LG + G +E + + F+KSI+ G A DGR+R D L+AVNG S G
Sbjct: 596 SGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLG 652
Score = 68.2 bits (165), Expect = 2e-11
Identities = 55/186 (29%), Positives = 92/186 (49%), Gaps = 12/186 (6%)
Query: 310 VFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQAS--ERRVHLVVSRQ 367
+++ N+L G A + G+L+ DR++ +NG DL S E L++++ E V L+V RQ
Sbjct: 488 IYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQ 547
Query: 368 VRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQ---KDPGES-LG 423
D F N+ S P E + + T + + + D G + LG
Sbjct: 548 -----EDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLG 602
Query: 424 MTVAGGASHREW-DLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALL 482
++V G S DL I+V S+ GG S+DGR++ D L+ V+G L + +A+ L
Sbjct: 603 VSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETL 662
Query: 483 KRTSSS 488
+R+ S+
Sbjct: 663 RRSMST 668
Score = 58.2 bits (139), Expect = 2e-08
Identities = 53/208 (25%), Positives = 92/208 (44%), Gaps = 39/208 (18%)
Query: 195 VGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQ- 253
+GGS I +++I G +DGRL GD +++VNG+D+ V LLR
Sbjct: 482 IGGSAP----IYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKME 537
Query: 254 --VLWLTVMREQKFRSR------NNGQAPDAYRPRDD-------------SFHVILNKSS 292
V L +E F R + Q P + D+ +F V LN S
Sbjct: 538 GTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSG 597
Query: 293 PEEQLGIKLVRKVDEP-----GVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPE 347
LG+ + + G+F+ ++++GG A + G+L ND+++A+NG L + +
Sbjct: 598 -SAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQ 656
Query: 348 SAAHLIQAS-------ERRVHLVVSRQV 368
A ++ S + L+V+R++
Sbjct: 657 DAMETLRRSMSTEGNKRGMIQLIVARRI 684
Score = 45.4 bits (106), Expect = 2e-04
Identities = 27/84 (32%), Positives = 44/84 (52%), Gaps = 1/84 (1%)
Query: 542 DIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRST 601
+I L++ T G LGF I G+ P ++K+I+ A DGR++ GD L+ VNG
Sbjct: 461 NIQLKKGTEG-LGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDL 519
Query: 602 SGMIHACLARLLKELKGRITLTIV 625
G + LL+ K T++++
Sbjct: 520 VGKSQEEVVSLLRSTKMEGTVSLL 543
>gi|119120907 par-3 partitioning defective 3 homolog B isoform a
[Homo sapiens]
Length = 1104
Score = 79.7 bits (195), Expect = 7e-15
Identities = 77/276 (27%), Positives = 129/276 (46%), Gaps = 48/276 (17%)
Query: 369 RQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAG 428
+ +SP + + G S+ S SP G SN + ++++K P E LG TV
Sbjct: 349 QNKSPRVPRLGGKPSSPSLSPLMGFGSNK--------NAKKIKIDLKKGP-EGLGFTVVT 399
Query: 429 GASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRT--- 485
S PI+V ++ P G +DGR+++GD +L V+G ++T ++ E VA+L+ T
Sbjct: 400 RDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQG 459
Query: 486 -SSSIVLKALE----VKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNC 540
++S+V+ E +E + + DC + +L+++ + E+P
Sbjct: 460 ETASLVIARQEGHFLPRELKGEPDCCA-LSLETSEQLT------------FEIP------ 500
Query: 541 KDIVLRRNTAGSLGFCIVGGYEEYNG-NKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGR 599
L + + LG + G G + FIKSI+ G A+ DGR+R D L+AVNG
Sbjct: 501 ----LNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGE 556
Query: 600 STSGMI-HACLARLLK------ELKGRITLTIVSWP 628
S G H + L + ++G I L I+ P
Sbjct: 557 SLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRP 592
Score = 62.8 bits (151), Expect = 9e-10
Identities = 60/226 (26%), Positives = 95/226 (42%), Gaps = 24/226 (10%)
Query: 205 IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQ--VLWLTVMRE 262
I +++I G +DGRL GD IL+VNG D++ V +LR Q L + R+
Sbjct: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469
Query: 263 Q-KFRSRNNGQAPDAYR-----PRDDSFHVILNKSSPEEQLGIKLVRKVDEP-----GVF 311
+ F R PD +F + LN S LG+ L G+F
Sbjct: 470 EGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSG-SAGLGVSLKGNKSRETGTDLGIF 528
Query: 312 IFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQAS-------ERRVHLVV 364
I +++ GG A++ G+L ND+++A+NG L S A ++ S + LV+
Sbjct: 529 IKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVI 588
Query: 365 SRQVRQRSPDIFQEAGWNS---NGSWSPGPGERSNTPKPLHPTITC 407
R+ + D + ++ + R N LHP TC
Sbjct: 589 LRRPERPMEDPAECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTC 634
>gi|119120903 par-3 partitioning defective 3 homolog B isoform c
[Homo sapiens]
Length = 1136
Score = 79.7 bits (195), Expect = 7e-15
Identities = 77/276 (27%), Positives = 129/276 (46%), Gaps = 48/276 (17%)
Query: 369 RQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAG 428
+ +SP + + G S+ S SP G SN + ++++K P E LG TV
Sbjct: 349 QNKSPRVPRLGGKPSSPSLSPLMGFGSNK--------NAKKIKIDLKKGP-EGLGFTVVT 399
Query: 429 GASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRT--- 485
S PI+V ++ P G +DGR+++GD +L V+G ++T ++ E VA+L+ T
Sbjct: 400 RDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQG 459
Query: 486 -SSSIVLKALE----VKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNC 540
++S+V+ E +E + + DC + +L+++ + E+P
Sbjct: 460 ETASLVIARQEGHFLPRELKGEPDCCA-LSLETSEQLT------------FEIP------ 500
Query: 541 KDIVLRRNTAGSLGFCIVGGYEEYNG-NKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGR 599
L + + LG + G G + FIKSI+ G A+ DGR+R D L+AVNG
Sbjct: 501 ----LNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGE 556
Query: 600 STSGMI-HACLARLLK------ELKGRITLTIVSWP 628
S G H + L + ++G I L I+ P
Sbjct: 557 SLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRP 592
Score = 62.8 bits (151), Expect = 9e-10
Identities = 60/226 (26%), Positives = 95/226 (42%), Gaps = 24/226 (10%)
Query: 205 IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQ--VLWLTVMRE 262
I +++I G +DGRL GD IL+VNG D++ V +LR Q L + R+
Sbjct: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469
Query: 263 Q-KFRSRNNGQAPDAYR-----PRDDSFHVILNKSSPEEQLGIKLVRKVDEP-----GVF 311
+ F R PD +F + LN S LG+ L G+F
Sbjct: 470 EGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSG-SAGLGVSLKGNKSRETGTDLGIF 528
Query: 312 IFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQAS-------ERRVHLVV 364
I +++ GG A++ G+L ND+++A+NG L S A ++ S + LV+
Sbjct: 529 IKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVI 588
Query: 365 SRQVRQRSPDIFQEAGWNS---NGSWSPGPGERSNTPKPLHPTITC 407
R+ + D + ++ + R N LHP TC
Sbjct: 589 LRRPERPMEDPAECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTC 634
>gi|87196343 PDZ domain containing 2 [Homo sapiens]
Length = 2839
Score = 79.0 bits (193), Expect = 1e-14
Identities = 104/495 (21%), Positives = 191/495 (38%), Gaps = 91/495 (18%)
Query: 180 KINRVDPSESLSIRLVGG--SETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDIS 237
K+ + S+ L I++ GG S+ I++ + G RDGRL GD +L +NG +
Sbjct: 334 KMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLV 393
Query: 238 NVPHNYAVRLLRQPCQVLWLTVMREQK----------------------FRSRNNGQAPD 275
+ H AV +LR ++ L V ++ S + + +
Sbjct: 394 GLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSSWTDNEDQE 453
Query: 276 AYRPRDDSFHVILNKSSP-----------EEQLGIKLVRKVDEPGVFIFNVLDGGVAYRH 324
A D+ + ++ P EE G K + + + L GGV +R
Sbjct: 454 ADGEEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSRLSGGV-HRL 512
Query: 325 GQLEENDRVLAINGHDL-------RYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQ 377
+EE + ++ NG R G S L+ +S + ++ +
Sbjct: 513 ESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSSSASQEYHIVKKSTRSLSTTQV 572
Query: 378 EAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDL 437
E+ W + + P++ ++ + K+ G+ LG ++AGG +
Sbjct: 573 ESPW-----------------RLIRPSVI---SIIGLYKEKGKGLGFSIAGGRDCIRGQM 612
Query: 438 PIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVK 497
I+V ++ P G + DGR+K GD +L+V+G+ + ++ EA+ K+ S + + + K
Sbjct: 613 GIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTK 672
Query: 498 EYEPQ-EDCSSPAALD---------SNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRR 547
P CS+P + S A SD S + + P KD ++
Sbjct: 673 LVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTP----GPKDRIVME 728
Query: 548 NTAG-------SLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNG-- 598
T +G C + N +I S+ G+ A + + GD +L VN
Sbjct: 729 VTLNKEPRVGLGIGACCLA---LENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVN 785
Query: 599 --RSTSGMIHACLAR 611
+ +HA L++
Sbjct: 786 VRHAALSKVHAILSK 800
Score = 62.0 bits (149), Expect = 2e-09
Identities = 50/215 (23%), Positives = 93/215 (43%), Gaps = 11/215 (5%)
Query: 414 IQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEV 473
+ + G LG +VAGG + ++ + + G S++G + GD LL+V+G L +
Sbjct: 2625 LNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQ--GAASQEGTMNRGDFLLSVNGASLAGL 2682
Query: 474 SRSEAVALLKRTS---SSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMW 530
+ + +L + ++V+ + + P P A P
Sbjct: 2683 AHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRS 2742
Query: 531 LELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCG 590
+ + L C +++ T+ LG + GG G+ P IK + +G A G I G
Sbjct: 2743 VAVHDAL--CVEVL---KTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAG 2797
Query: 591 DILLAVNGRSTSGMIHACLARLLKEL-KGRITLTI 624
D +LA+NG+ G++H ++K + +G + L I
Sbjct: 2798 DEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLI 2832
Score = 57.4 bits (137), Expect = 4e-08
Identities = 77/330 (23%), Positives = 136/330 (41%), Gaps = 36/330 (10%)
Query: 310 VFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVS---- 365
+ + V +GG A+R G+L D +L INGH L S E A +++++ V LVV+
Sbjct: 361 IVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKEN 420
Query: 366 ------RQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPG 419
R + PD+ SW+ + ++ + T + ++ + +P
Sbjct: 421 SAEDLLRLTSKSLPDLTSSV--EDVSSWTDNEDQEADGEED-EGTSSSVQRAMPGTDEPQ 477
Query: 420 ESLGMTVAGG--ASHREWDLPIYVISVEPGGVISRDGRIKTGDILL-NVDG-VELTEVSR 475
+ G + G S ++ I + S GGV + + ++++ N D + + EVSR
Sbjct: 478 DVCGAEESKGNLESPKQGSNKIKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSR 537
Query: 476 SEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPR 535
K + ++ + +EY + S +L + +P PS +
Sbjct: 538 DGR----KHSLPQLLDSSSASQEYHIVK--KSTRSLSTTQVESPWRLIRPSVI------- 584
Query: 536 CLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLA 595
I L + LGF I GG + G F+K+I A DGR++ GD +L
Sbjct: 585 -----SIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILD 639
Query: 596 VNGRSTSGMIHACLARLLKELK-GRITLTI 624
VNG G+ K+++ G LT+
Sbjct: 640 VNGIPIKGLTFQEAIHTFKQIRSGLFVLTV 669
Score = 48.5 bits (114), Expect = 2e-05
Identities = 79/361 (21%), Positives = 129/361 (35%), Gaps = 66/361 (18%)
Query: 67 EVSAAATISLMTDEPGLDNPAYVSSAEDGQPAISPVDSGRSNRTRARPFERSTIRSRSFK 126
E + S+ PG D P V AE+ + + G + R S +
Sbjct: 457 EEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSRLSGGVHRLESVE 516
Query: 127 KIN-----------RALSVLRRTK----------SGSAVANHADQGRENSENTTAPEVFP 165
+ N R L V R + S ++ H + S +TT E
Sbjct: 517 EYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSSSASQEYHIVKKSTRSLSTTQVE--- 573
Query: 166 RLYHLIPDGEITSIKINRVDPSESLSIRLVGGSET--PLVHIIIQHIYRDGVIARDGRLL 223
+ LI I+ I + + + + L + GG + + I ++ I+ +G A DGRL
Sbjct: 574 SPWRLIRPSVISIIGLYK-EKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLK 632
Query: 224 PGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQ-------------------- 263
GD IL VNG+ I + A+ +Q L++ +R +
Sbjct: 633 EGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSAS 692
Query: 264 -KFRSRNNGQAPDAYRPRDDS-------------FHVILNKSSPEEQLGIK---LVRKVD 306
F + A + S V LNK P LGI L +
Sbjct: 693 PNFNTSGGASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNK-EPRVGLGIGACCLALENS 751
Query: 307 EPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESA-AHLIQASERRVHLVVS 365
PG++I ++ G VA L D++L +N ++R+ + A L + V LV+
Sbjct: 752 PPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIG 811
Query: 366 R 366
R
Sbjct: 812 R 812
Score = 45.4 bits (106), Expect = 2e-04
Identities = 54/240 (22%), Positives = 94/240 (39%), Gaps = 48/240 (20%)
Query: 130 RALSVLRRTKSGSAVANHADQGRENSENTTAPEVFPRLYHLIPDGEITSIKINRVDPSES 189
R SVL S S + + + SEN + ++ I +NR + S
Sbjct: 2589 RLQSVLSSVGSKSTILTLIQEAKAQSEN---------------EEDVCFIVLNRKEGS-G 2632
Query: 190 LSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLR 249
L + GG++ I + ++ G +++G + GD +L VNG ++ + H +++L
Sbjct: 2633 LGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLH 2692
Query: 250 Q-PCQVLWLTVMREQKFRSRNNG-QAPDAYRPRDDSFHVILNKSSPEEQ----------- 296
Q L V+++ + R + Q P P + ++ K+ P E
Sbjct: 2693 QAQLHKDALVVIKKGMDQPRPSARQEP----PTANGKGLLSRKTIPLEPGIGRSVAVHDA 2748
Query: 297 -----------LGIKL----VRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDL 341
LG+ L + + I V GG A + G +E D +LAING L
Sbjct: 2749 LCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPL 2808
Score = 43.5 bits (101), Expect = 6e-04
Identities = 22/74 (29%), Positives = 33/74 (44%)
Query: 553 LGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARL 612
LG + GG + + EG A+ DGR+ GD LL +NG G+ H +
Sbjct: 344 LGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAI 403
Query: 613 LKELKGRITLTIVS 626
L+ G + L + S
Sbjct: 404 LRSATGMVQLVVAS 417
Score = 40.8 bits (94), Expect = 0.004
Identities = 23/73 (31%), Positives = 36/73 (49%), Gaps = 2/73 (2%)
Query: 543 IVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTS 602
IVL R LGF + GG + K + + A +G + GD LL+VNG S +
Sbjct: 2623 IVLNRKEGSGLGFSVAGGTDV--EPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLA 2680
Query: 603 GMIHACLARLLKE 615
G+ H + ++L +
Sbjct: 2681 GLAHGNVLKVLHQ 2693
Score = 30.4 bits (67), Expect = 5.2
Identities = 22/75 (29%), Positives = 37/75 (49%), Gaps = 6/75 (8%)
Query: 187 SESLSIRLVGG--SETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYA 244
S L + L GG S T ++I+ +Y+ G + G + GD IL +NG + + H A
Sbjct: 2757 SAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDA 2816
Query: 245 VRLLRQ----PCQVL 255
+++ P Q+L
Sbjct: 2817 WNIMKSVPEGPVQLL 2831
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
2 [Homo sapiens]
Length = 2466
Score = 77.4 bits (189), Expect = 4e-14
Identities = 123/547 (22%), Positives = 209/547 (38%), Gaps = 89/547 (16%)
Query: 127 KINRALSVLRRTKSGSAVANHADQGR-ENSENTTAPEVFPRLYHLI--PDGEITSIKINR 183
K+N + SV +S + +D E+ +V + + ++ P+ EIT + + +
Sbjct: 1020 KLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLDVLHKRWSIVSSPEREITLVNLKK 1079
Query: 184 VDPSESLSIRLVGGSETPLVH--IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPH 241
D L +++GG + + I I + G DG L PGD ++ VN + + V H
Sbjct: 1080 -DAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSH 1138
Query: 242 NYAVRLLRQPCQVLWLTVMREQKFRSR------------NNGQAPDAYRPRDDSFHVILN 289
+ A+ +L+ + + L + + ++ S+ N +Y DS ++
Sbjct: 1139 HAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSY--MQDS---AID 1193
Query: 290 KSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEEND--------RVLAING--- 338
SS + +R + E N R G L D +NG
Sbjct: 1194 SSSKDHHWSRGTLRHISE------NSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFA 1247
Query: 339 --------HDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPG 390
+ ++GSP S + + +A+E+ S Q + + P I ++ G
Sbjct: 1248 SHLGDQTWQESQHGSP-SPSVISKATEKET-FTDSNQSKTKKPGISDVTDYSDRGDSDMD 1305
Query: 391 PGERSN-----TPKPLHPTITCHEKVVNIQ------KDPGE-----------SLGMTVAG 428
S+ TPK + +N + PG+ SLG++V G
Sbjct: 1306 EATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTG 1365
Query: 429 GASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSS 488
G + IYV +V P G DGRI GD +L V+GV L + +AV L+ T
Sbjct: 1366 GVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQV 1425
Query: 489 IVL-----KALEVKEY---EPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNC 540
+ L ++ KE+ PQ S A + + E N
Sbjct: 1426 VHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTE-----ENT 1480
Query: 541 KDIVLRRNTAGSLGFCIV---GGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVN 597
++ L +N++G LGF E +K + G PA G+I GD++L VN
Sbjct: 1481 FEVKLFKNSSG-LGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVN 1539
Query: 598 GRSTSGM 604
G S G+
Sbjct: 1540 GASLKGL 1546
Score = 70.9 bits (172), Expect = 3e-12
Identities = 111/529 (20%), Positives = 199/529 (37%), Gaps = 105/529 (19%)
Query: 174 GEITSIKINRVDPSESLSIRLVGGSETPLVH--IIIQHIYRDGVIARDGRLLPGDIILKV 231
G+I +++ + D SL I + GG T + H I ++ + G DGR+ GD +L V
Sbjct: 1345 GDIFEVELAKND--NSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAV 1402
Query: 232 NGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNN---------------GQAPD- 275
NG+ + H AV LR QV+ L + + Q S+ + GQ P+
Sbjct: 1403 NGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEK 1462
Query: 276 ----------AYRPRDDSFHVILNKSSPEEQLGIKLVR-------KVDEPGVFIFNVLDG 318
++ +++F V L K+S LG R +++ V + + G
Sbjct: 1463 VKKTTQVKDYSFVTEENTFEVKLFKNS--SGLGFSFSREDNLIPEQINASIVRVKKLFPG 1520
Query: 319 GVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQE 378
A G+++ D +L +NG L+ S + ++ + V L++ R P+I
Sbjct: 1521 QPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTA 1580
Query: 379 --AGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQ-----KDPGESLGMTVAGGAS 431
S P + S+ P + + + E ++ + K P + + G+
Sbjct: 1581 LLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSG 1640
Query: 432 HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVL 491
+ + P + + L N+ VS++++ ++ +
Sbjct: 1641 EDD-------LVTAPANISNSTWSSALHQTLSNM-------VSQAQSHHEAPKSQEDTIC 1686
Query: 492 KALEVKEYEPQEDCSSPAALDSNHNMAPP-----------SDWSPSWVM----------- 529
Y PQ+ + P DSN + PP S+ + S M
Sbjct: 1687 TMF----YYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEP 1742
Query: 530 -----WLELPRCLYNCKD---------IVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSI 575
W L L N + I L ++ GSLGF + G N ++ +
Sbjct: 1743 TRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKG----NQRIGCYVHDV 1798
Query: 576 VEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTI 624
++ PA +DGR++ GD L+ VN + M H LL+ + L I
Sbjct: 1799 IQ-DPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVI 1846
Score = 47.8 bits (112), Expect = 3e-05
Identities = 53/243 (21%), Positives = 99/243 (40%), Gaps = 45/243 (18%)
Query: 292 SPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAH 351
S + LG + + G ++ +V+ A G+L+ DR++ +N D+ + A +
Sbjct: 1775 SEKGSLGFTVTKGNQRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNMTHTDAVN 1833
Query: 352 LIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHP----TITC 407
L++A+ + V LV+ R + E P H T+TC
Sbjct: 1834 LLRAASKTVRLVIGRVL------------------------ELPRIPMLPHLLPDITLTC 1869
Query: 408 HEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDG 467
++ E LG ++ GG H +Y+ + P V + +G ++ D++ V+G
Sbjct: 1870 NK----------EELGFSLCGG--HDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNG 1917
Query: 468 VELTEVSRSEAVALLKRTSSSIVLKA----LEVKEYEPQEDCSSPAALDSNHNMAPPSDW 523
V ++ E L + S+VLKA L V + S+P + N + + S
Sbjct: 1918 VSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCS 1977
Query: 524 SPS 526
P+
Sbjct: 1978 QPA 1980
Score = 47.4 bits (111), Expect = 4e-05
Identities = 27/80 (33%), Positives = 42/80 (52%)
Query: 545 LRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGM 604
L+++ LGF I+GG + + FI S+ G PA DG ++ GD L++VN S G+
Sbjct: 1077 LKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGV 1136
Query: 605 IHACLARLLKELKGRITLTI 624
H +L+ +TL I
Sbjct: 1137 SHHAAIEILQNAPEDVTLVI 1156
Score = 47.0 bits (110), Expect = 5e-05
Identities = 54/219 (24%), Positives = 88/219 (40%), Gaps = 42/219 (19%)
Query: 386 SWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVE 445
+W+P + N + + E ++ + K SLG TV G + YV V
Sbjct: 1747 NWTPLKNDLENHLEDFELEV---ELLITLIKSEKGSLGFTVTKGNQR----IGCYVHDVI 1799
Query: 446 PGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDC 505
S DGR+K GD L+ V+ ++T ++ ++AV LL+ S ++ L V E
Sbjct: 1800 QDPAKS-DGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELP----- 1853
Query: 506 SSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYN 565
+P + DI L N LGF + GG++
Sbjct: 1854 --------------------------RIPMLPHLLPDITLTCNKE-ELGFSLCGGHDSLY 1886
Query: 566 GNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGM 604
+ +I I + A +G ++ D++ VNG ST GM
Sbjct: 1887 --QVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGM 1923
Score = 43.5 bits (101), Expect = 6e-04
Identities = 56/218 (25%), Positives = 89/218 (40%), Gaps = 29/218 (13%)
Query: 203 VHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMRE 262
VH +IQ + DGRL PGD ++KVN D++N+ H AV LLR + + L + R
Sbjct: 1795 VHDVIQDPAKS-----DGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRV 1849
Query: 263 QKFRSRNNGQAPDAYRPRDDSF-HVI--LNKSSPEEQLGIKLVRKVDE--PGVFIFNVLD 317
+ PR H++ + + +E+LG L D V+I ++
Sbjct: 1850 LEL-------------PRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINP 1896
Query: 318 GGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQ 377
VA G L+ D + +NG + + E + S + L +R P +
Sbjct: 1897 RSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKR 1956
Query: 378 EA-----GWNSNGSWSPGP-GERSNTPKPLHPTITCHE 409
A NGS+S G + + TP T+ E
Sbjct: 1957 SAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEE 1994
Score = 31.6 bits (70), Expect = 2.3
Identities = 24/70 (34%), Positives = 32/70 (45%), Gaps = 7/70 (10%)
Query: 165 PRLYHLIPDGEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLP 224
P L HL+PD +T K E L L GG ++ + I I V A +G L
Sbjct: 1856 PMLPHLLPDITLTCNK-------EELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQL 1908
Query: 225 GDIILKVNGM 234
D+I VNG+
Sbjct: 1909 LDVIHYVNGV 1918
>gi|122937249 glutamate receptor interacting protein 2 [Homo
sapiens]
Length = 1141
Score = 77.4 bits (189), Expect = 4e-14
Identities = 58/206 (28%), Positives = 96/206 (46%), Gaps = 33/206 (16%)
Query: 411 VVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVEL 470
VV + K G +LG+T++GG D V ++ PGG+ +R + GD + +V+G+ L
Sbjct: 145 VVELIKKEGSTLGLTISGGTDK---DGKPRVSNLRPGGLAARSDLLNIGDYIRSVNGIHL 201
Query: 471 TEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMW 530
T + E + LLK +VL+ EYE P A ++N
Sbjct: 202 TRLRHDEIITLLKNVGERVVLEV----EYE-----LPPPAPENN---------------- 236
Query: 531 LELPRCLYNCKDIVLRRNTAGSLGFCIVGG-YEEYNGNKPFFIKSIVEGTPAYNDGRIRC 589
PR + D+ L + S GF + GG +E+ + ++P + + G PA +G ++
Sbjct: 237 ---PRIISKTVDVSLYKE-GNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKV 292
Query: 590 GDILLAVNGRSTSGMIHACLARLLKE 615
GD LL+V+G G HA L++
Sbjct: 293 GDRLLSVDGIPLHGASHATALATLRQ 318
Score = 70.1 bits (170), Expect = 6e-12
Identities = 90/331 (27%), Positives = 136/331 (41%), Gaps = 52/331 (15%)
Query: 172 PDGEITSIKINRV----DPSESLSIRLVGG---SETPLVHIIIQHIYRDGVIARDGRLLP 224
P G+I + V DP ++L GG +ET ++ I D R G L
Sbjct: 543 PGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQV 602
Query: 225 GDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSF 284
GD +L +NG+ + A +LLR L V+ E +F ++ P +F
Sbjct: 603 GDRVLSINGIATEDGTMEEANQLLRD--AALAHKVVLEVEF------DVAESVIPSSGTF 654
Query: 285 HVILNKSSPEEQLGIKL---VRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDL 341
HV L K E LGI + RK EP + I ++ G VA+R G LE D++LAI+ L
Sbjct: 655 HVKLPKKRSVE-LGITISSASRKRGEP-LIISDIKKGSVAHRTGTLEPGDKLLAIDNIRL 712
Query: 342 RYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPL 401
E A +++ E V L + + N G S T +
Sbjct: 713 DNCPMEDAVQILRQCEDLVKLKIRKD--------------EDNSDELETTGAVSYTVE-- 756
Query: 402 HPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDI 461
K G LG+T++G + +D PI + + G+ R G I GD
Sbjct: 757 -------------LKRYGGPLGITISG--TEEPFD-PIVISGLTKRGLAERTGAIHVGDR 800
Query: 462 LLNVDGVELTEVSRSEAVALLKRTSSSIVLK 492
+L ++ V L SEA+ LL+ ++ LK
Sbjct: 801 ILAINNVSLKGRPLSEAIHLLQVAGETVTLK 831
Score = 65.5 bits (158), Expect = 1e-10
Identities = 79/330 (23%), Positives = 127/330 (38%), Gaps = 49/330 (14%)
Query: 207 IQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFR 266
+ ++ G+ AR L GD I VNG+ ++ + H+ + LL+ + + L V E
Sbjct: 172 VSNLRPGGLAARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEVEYELPPP 231
Query: 267 SRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDEPG-----VFIFNVLDGGVA 321
+ N PR S V ++ G L E G + + V GG A
Sbjct: 232 APENN-------PRIISKTVDVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPA 284
Query: 322 YRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGW 381
R G L+ DR+L+++G L S +A ++ V V
Sbjct: 285 DREGSLKVGDRLLSVDGIPLHGASHATALATLRQCSHEALFQVEYDVAT----------- 333
Query: 382 NSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYV 441
P +N PL +V I K PG +LG+++ + + I +
Sbjct: 334 ---------PDTVANASGPL---------MVEIVKTPGSALGISLTTTSLRNK--SVITI 373
Query: 442 ISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYE- 500
++P V+ R G + GD +L++DG + S EA LL S + L+ L V + +
Sbjct: 374 DRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVRLEILPVPQSQR 433
Query: 501 ---PQEDCSSPAALDSNHNMAP--PSDWSP 525
PQ + H P PS SP
Sbjct: 434 PLRPQRQVVKVQRSEQLHRWDPCVPSCHSP 463
Score = 59.3 bits (142), Expect = 1e-08
Identities = 57/215 (26%), Positives = 92/215 (42%), Gaps = 46/215 (21%)
Query: 290 KSSPEEQLGIKLVRKVDEPGVF----------------IFNVLDGGVAYRHGQLEENDRV 333
+S PEE GI +V + + G + N+ GG+A R L D +
Sbjct: 134 QSIPEEFRGITVVELIKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDLLNIGDYI 193
Query: 334 LAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGE 393
++NG L + L++ RV L V ++ +P+
Sbjct: 194 RSVNGIHLTRLRHDEIITLLKNVGERVVLEVEYELPPPAPE------------------- 234
Query: 394 RSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREW--DLPIYVISVEPGGVIS 451
N P+ + T+ V++ K+ G S G + GGA H + P+ + V PGG
Sbjct: 235 --NNPRIISKTVD-----VSLYKE-GNSFGFVLRGGA-HEDGHKSRPLVLTYVRPGGPAD 285
Query: 452 RDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTS 486
R+G +K GD LL+VDG+ L S + A+A L++ S
Sbjct: 286 REGSLKVGDRLLSVDGIPLHGASHATALATLRQCS 320
Score = 55.5 bits (132), Expect = 2e-07
Identities = 81/331 (24%), Positives = 124/331 (37%), Gaps = 70/331 (21%)
Query: 296 QLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQ- 354
Q GI + P + F D A R G L+ DRVL+ING G+ E A L++
Sbjct: 570 QGGIFATETLSSPPLVCFIEPDSP-AERCGLLQVGDRVLSINGIATEDGTMEEANQLLRD 628
Query: 355 -ASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVN 413
A +V L V V + S P G T H V
Sbjct: 629 AALAHKVVLEVEFDVAE---------------SVIPSSG-------------TFH---VK 657
Query: 414 IQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEV 473
+ K LG+T++ + R P+ + ++ G V R G ++ GD LL +D + L
Sbjct: 658 LPKKRSVELGITISSASRKR--GEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNC 715
Query: 474 SRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLEL 533
+AV +L++ + LK K+ + ++ + A+ +EL
Sbjct: 716 PMEDAVQILRQCEDLVKLKIR--KDEDNSDELETTGAVSYT----------------VEL 757
Query: 534 PRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDIL 593
R G LG I G E ++ P I + + A G I GD +
Sbjct: 758 KRY-------------GGPLGITISGTEEPFD---PIVISGLTKRGLAERTGAIHVGDRI 801
Query: 594 LAVNGRSTSGMIHACLARLLKELKGRITLTI 624
LA+N S G + LL+ +TL I
Sbjct: 802 LAINNVSLKGRPLSEAIHLLQVAGETVTLKI 832
Score = 55.5 bits (132), Expect = 2e-07
Identities = 50/199 (25%), Positives = 88/199 (44%), Gaps = 9/199 (4%)
Query: 170 LIPDGEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIIL 229
+IP +K+ + S L I + S +II I + V R G L PGD +L
Sbjct: 647 VIPSSGTFHVKLPK-KRSVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLL 705
Query: 230 KVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILN 289
++ + + N P AV++LRQ ++ L + +++ + + S+ V L
Sbjct: 706 AIDNIRLDNCPMEDAVQILRQCEDLVKLKIRKDE-------DNSDELETTGAVSYTVELK 758
Query: 290 KSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESA 349
+ + I + +P + I + G+A R G + DR+LAIN L+ A
Sbjct: 759 RYGGPLGITISGTEEPFDP-IVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEA 817
Query: 350 AHLIQASERRVHLVVSRQV 368
HL+Q + V L + +Q+
Sbjct: 818 IHLLQVAGETVTLKIKKQL 836
Score = 44.3 bits (103), Expect = 3e-04
Identities = 39/162 (24%), Positives = 67/162 (41%), Gaps = 11/162 (6%)
Query: 205 IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQK 264
+++ ++ G R+G L GD +L V+G+ + H A+ LRQ E
Sbjct: 273 LVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQ--------CSHEAL 324
Query: 265 FRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKV--DEPGVFIFNVLDGGVAY 322
F+ + PD V + K +P LGI L ++ + I + V
Sbjct: 325 FQVEYDVATPDTVANASGPLMVEIVK-TPGSALGISLTTTSLRNKSVITIDRIKPASVVD 383
Query: 323 RHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVV 364
R G L D +L+I+G + + S A L+ + +V L +
Sbjct: 384 RSGALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVRLEI 425
Score = 37.4 bits (85), Expect = 0.042
Identities = 91/443 (20%), Positives = 152/443 (34%), Gaps = 63/443 (14%)
Query: 186 PSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAV 245
P +L I L S I I I V+ R G L PGD IL ++G + + A
Sbjct: 352 PGSALGISLTTTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEAT 411
Query: 246 RLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKV 305
+LL + + L ++ P + RP V+ + S + V
Sbjct: 412 KLLASISEKVRLEIL-----------PVPQSQRPLRPQRQVVKVQRSEQLHRWDPCVPSC 460
Query: 306 DEPGVFIFNVLDGGVAYRHGQ---LEENDRVLAINGHDLRYGSPESAAHLIQASERRVHL 362
P + Q L H +P + Q R +
Sbjct: 461 HSPRPGHCRMPTWATPAGQDQSRSLSSTPFSSPTLNHAFSCNNPSTLPRGSQPMSPRTTM 520
Query: 363 VVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESL 422
RQ R+ S S + GPG + +H T V + DP
Sbjct: 521 GRRRQRRREHKSSL------SLASSTVGPGGQI-----VHTETT----EVVLCGDPLSGF 565
Query: 423 GMTVAGGASHRE-WDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVAL 481
G+ + GG E P V +EP R G ++ GD +L+++G+ + + EA L
Sbjct: 566 GLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEANQL 625
Query: 482 LKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCK 541
L+ +++ K + E++ E PS S ++LP
Sbjct: 626 LR--DAALAHKVVLEVEFDVAES-------------VIPS----SGTFHVKLP------- 659
Query: 542 DIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRST 601
+ + LG I + +P I I +G+ A+ G + GD LLA++
Sbjct: 660 -----KKRSVELGITISSASRK--RGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRL 712
Query: 602 SGMIHACLARLLKELKGRITLTI 624
++L++ + + L I
Sbjct: 713 DNCPMEDAVQILRQCEDLVKLKI 735
Score = 30.8 bits (68), Expect = 4.0
Identities = 29/106 (27%), Positives = 44/106 (41%), Gaps = 10/106 (9%)
Query: 286 VILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGS 345
V L+K G + + E GV++ V G A+R G L+ DRVL +N R
Sbjct: 1040 VTLHKDPMRHDFGFSVSDGLLEKGVYVHTVRPDGPAHR-GGLQPFDRVLQVNHVRTRDFD 1098
Query: 346 PESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGP 391
A L+ + + L++SR+ +S SPGP
Sbjct: 1099 CCLAVPLLAEAGDVLELIISRK---------PHTAHSSRAPRSPGP 1135
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 77.0 bits (188), Expect = 5e-14
Identities = 117/523 (22%), Positives = 203/523 (38%), Gaps = 88/523 (16%)
Query: 150 QGRENSENTTAPEVFPRLYHLI--PDGEITSIKINRVDPSESLSIRLVGGSETPLVH--I 205
+ R+++++ +V + + ++ P+ EIT + + + D L +++GG + + I
Sbjct: 872 RARQSNQDAQDIDVLHKRWSIVSSPEREITLVNLKK-DAKYGLGFQIIGGEKMGRLDLGI 930
Query: 206 IIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKF 265
I + G DG L PGD ++ VN + + V H+ A+ +L+ + + L + + ++
Sbjct: 931 FISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEK 990
Query: 266 RSR------------NNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDEPGVFIF 313
S+ N +Y DS ++ SS + +R + E
Sbjct: 991 ISKVPSTPVHLTNEMKNYMKKSSY--MQDS---AIDSSSKDHHWSRGTLRHISE------ 1039
Query: 314 NVLDGGVAYRHGQLEEND--------RVLAING-----------HDLRYGSPESAAHLIQ 354
N R G L D +NG + ++GSP S + + +
Sbjct: 1040 NSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGDQTWQESQHGSP-SPSVISK 1098
Query: 355 ASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSN-----TPKPLHPTITCHE 409
A+E+ S Q + + P I ++ G S+ TPK +
Sbjct: 1099 ATEKET-FTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTS 1157
Query: 410 KVVNIQ------KDPGE-----------SLGMTVAGGASHREWDLPIYVISVEPGGVISR 452
+N + PG+ SLG++V GG + IYV +V P G
Sbjct: 1158 NKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAES 1217
Query: 453 DGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVL-----KALEVKEY---EPQED 504
DGRI GD +L V+GV L + +AV L+ T + L ++ KE+ PQ
Sbjct: 1218 DGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCT 1277
Query: 505 CSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIV---GGY 561
S A + + E N ++ L +N++G LGF
Sbjct: 1278 LSDQNAQGQGPEKVKKTTQVKDYSFVTE-----ENTFEVKLFKNSSG-LGFSFSREDNLI 1331
Query: 562 EEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGM 604
E +K + G PA G+I GD++L VNG S G+
Sbjct: 1332 PEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGL 1374
Score = 70.9 bits (172), Expect = 3e-12
Identities = 111/529 (20%), Positives = 199/529 (37%), Gaps = 105/529 (19%)
Query: 174 GEITSIKINRVDPSESLSIRLVGGSETPLVH--IIIQHIYRDGVIARDGRLLPGDIILKV 231
G+I +++ + D SL I + GG T + H I ++ + G DGR+ GD +L V
Sbjct: 1173 GDIFEVELAKND--NSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAV 1230
Query: 232 NGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNN---------------GQAPD- 275
NG+ + H AV LR QV+ L + + Q S+ + GQ P+
Sbjct: 1231 NGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEK 1290
Query: 276 ----------AYRPRDDSFHVILNKSSPEEQLGIKLVR-------KVDEPGVFIFNVLDG 318
++ +++F V L K+S LG R +++ V + + G
Sbjct: 1291 VKKTTQVKDYSFVTEENTFEVKLFKNS--SGLGFSFSREDNLIPEQINASIVRVKKLFPG 1348
Query: 319 GVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQE 378
A G+++ D +L +NG L+ S + ++ + V L++ R P+I
Sbjct: 1349 QPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTA 1408
Query: 379 --AGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQ-----KDPGESLGMTVAGGAS 431
S P + S+ P + + + E ++ + K P + + G+
Sbjct: 1409 LLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSG 1468
Query: 432 HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVL 491
+ + P + + L N+ VS++++ ++ +
Sbjct: 1469 EDD-------LVTAPANISNSTWSSALHQTLSNM-------VSQAQSHHEAPKSQEDTIC 1514
Query: 492 KALEVKEYEPQEDCSSPAALDSNHNMAPP-----------SDWSPSWVM----------- 529
Y PQ+ + P DSN + PP S+ + S M
Sbjct: 1515 TMF----YYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEP 1570
Query: 530 -----WLELPRCLYNCKD---------IVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSI 575
W L L N + I L ++ GSLGF + G N ++ +
Sbjct: 1571 TRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKG----NQRIGCYVHDV 1626
Query: 576 VEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTI 624
++ PA +DGR++ GD L+ VN + M H LL+ + L I
Sbjct: 1627 IQ-DPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVI 1674
Score = 47.8 bits (112), Expect = 3e-05
Identities = 53/243 (21%), Positives = 99/243 (40%), Gaps = 45/243 (18%)
Query: 292 SPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAH 351
S + LG + + G ++ +V+ A G+L+ DR++ +N D+ + A +
Sbjct: 1603 SEKGSLGFTVTKGNQRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNMTHTDAVN 1661
Query: 352 LIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHP----TITC 407
L++A+ + V LV+ R + E P H T+TC
Sbjct: 1662 LLRAASKTVRLVIGRVL------------------------ELPRIPMLPHLLPDITLTC 1697
Query: 408 HEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDG 467
++ E LG ++ GG H +Y+ + P V + +G ++ D++ V+G
Sbjct: 1698 NK----------EELGFSLCGG--HDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNG 1745
Query: 468 VELTEVSRSEAVALLKRTSSSIVLKA----LEVKEYEPQEDCSSPAALDSNHNMAPPSDW 523
V ++ E L + S+VLKA L V + S+P + N + + S
Sbjct: 1746 VSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCS 1805
Query: 524 SPS 526
P+
Sbjct: 1806 QPA 1808
Score = 47.4 bits (111), Expect = 4e-05
Identities = 27/80 (33%), Positives = 42/80 (52%)
Query: 545 LRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGM 604
L+++ LGF I+GG + + FI S+ G PA DG ++ GD L++VN S G+
Sbjct: 905 LKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGV 964
Query: 605 IHACLARLLKELKGRITLTI 624
H +L+ +TL I
Sbjct: 965 SHHAAIEILQNAPEDVTLVI 984
Score = 47.0 bits (110), Expect = 5e-05
Identities = 54/219 (24%), Positives = 88/219 (40%), Gaps = 42/219 (19%)
Query: 386 SWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVE 445
+W+P + N + + E ++ + K SLG TV G + YV V
Sbjct: 1575 NWTPLKNDLENHLEDFELEV---ELLITLIKSEKGSLGFTVTKGNQR----IGCYVHDVI 1627
Query: 446 PGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDC 505
S DGR+K GD L+ V+ ++T ++ ++AV LL+ S ++ L V E
Sbjct: 1628 QDPAKS-DGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELP----- 1681
Query: 506 SSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYN 565
+P + DI L N LGF + GG++
Sbjct: 1682 --------------------------RIPMLPHLLPDITLTCNKE-ELGFSLCGGHDSLY 1714
Query: 566 GNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGM 604
+ +I I + A +G ++ D++ VNG ST GM
Sbjct: 1715 --QVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGM 1751
Score = 43.5 bits (101), Expect = 6e-04
Identities = 56/218 (25%), Positives = 89/218 (40%), Gaps = 29/218 (13%)
Query: 203 VHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMRE 262
VH +IQ + DGRL PGD ++KVN D++N+ H AV LLR + + L + R
Sbjct: 1623 VHDVIQDPAKS-----DGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRV 1677
Query: 263 QKFRSRNNGQAPDAYRPRDDSF-HVI--LNKSSPEEQLGIKLVRKVDE--PGVFIFNVLD 317
+ PR H++ + + +E+LG L D V+I ++
Sbjct: 1678 LEL-------------PRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINP 1724
Query: 318 GGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQ 377
VA G L+ D + +NG + + E + S + L +R P +
Sbjct: 1725 RSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKR 1784
Query: 378 EA-----GWNSNGSWSPGP-GERSNTPKPLHPTITCHE 409
A NGS+S G + + TP T+ E
Sbjct: 1785 SAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEE 1822
Score = 31.6 bits (70), Expect = 2.3
Identities = 24/70 (34%), Positives = 32/70 (45%), Gaps = 7/70 (10%)
Query: 165 PRLYHLIPDGEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLP 224
P L HL+PD +T K E L L GG ++ + I I V A +G L
Sbjct: 1684 PMLPHLLPDITLTCNK-------EELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQL 1736
Query: 225 GDIILKVNGM 234
D+I VNG+
Sbjct: 1737 LDVIHYVNGV 1746
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 75.5 bits (184), Expect = 1e-13
Identities = 115/499 (23%), Positives = 190/499 (38%), Gaps = 86/499 (17%)
Query: 172 PDGEITSIKINRVDPSESLSIRLVGGSETPLVH--IIIQHIYRDGVIARDGRLLPGDIIL 229
P+ EIT + + + D L +++GG + + I I + G DG L PGD ++
Sbjct: 1087 PEREITLVNLKK-DAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLI 1145
Query: 230 KVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSR------------NNGQAPDAY 277
VN + + V H+ A+ +L+ + + L + + ++ S+ N +Y
Sbjct: 1146 SVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSY 1205
Query: 278 RPRDDSFHVILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEEND------ 331
DS ++ SS + +R + E N R G L D
Sbjct: 1206 --MQDS---AIDSSSKDHHWSRGTLRHISE------NSFGPSGGLREGSLSSQDSRTESA 1254
Query: 332 --RVLAING-----------HDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQE 378
+NG + ++GSP S + + +A+E+ S Q + + P I
Sbjct: 1255 SLSQSQVNGFFASHLGDQTWQESQHGSP-SPSVISKATEKET-FTDSNQSKTKKPGISDV 1312
Query: 379 AGWNSNGSWSPGPGERSN-----TPKPLHPTITCHEKVVNIQ------KDPGE------- 420
++ G S+ TPK + +N + PG+
Sbjct: 1313 TDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELA 1372
Query: 421 ----SLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRS 476
SLG++V GG + IYV +V P G DGRI GD +L V+GV L +
Sbjct: 1373 KNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHK 1432
Query: 477 EAVALLKRTSSSIVL-----KALEVKEY---EPQEDCSSPAALDSNHNMAPPSDWSPSWV 528
+AV L+ T + L ++ KE+ PQ S A + +
Sbjct: 1433 QAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYS 1492
Query: 529 MWLELPRCLYNCKDIVLRRNTAGSLGFCIV---GGYEEYNGNKPFFIKSIVEGTPAYNDG 585
E N ++ L +N++G LGF E +K + G PA G
Sbjct: 1493 FVTE-----ENTFEVKLFKNSSG-LGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESG 1546
Query: 586 RIRCGDILLAVNGRSTSGM 604
+I GD++L VNG S G+
Sbjct: 1547 KIDVGDVILKVNGASLKGL 1565
Score = 70.9 bits (172), Expect = 3e-12
Identities = 111/529 (20%), Positives = 199/529 (37%), Gaps = 105/529 (19%)
Query: 174 GEITSIKINRVDPSESLSIRLVGGSETPLVH--IIIQHIYRDGVIARDGRLLPGDIILKV 231
G+I +++ + D SL I + GG T + H I ++ + G DGR+ GD +L V
Sbjct: 1364 GDIFEVELAKND--NSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAV 1421
Query: 232 NGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNN---------------GQAPD- 275
NG+ + H AV LR QV+ L + + Q S+ + GQ P+
Sbjct: 1422 NGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEK 1481
Query: 276 ----------AYRPRDDSFHVILNKSSPEEQLGIKLVR-------KVDEPGVFIFNVLDG 318
++ +++F V L K+S LG R +++ V + + G
Sbjct: 1482 VKKTTQVKDYSFVTEENTFEVKLFKNS--SGLGFSFSREDNLIPEQINASIVRVKKLFPG 1539
Query: 319 GVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQE 378
A G+++ D +L +NG L+ S + ++ + V L++ R P+I
Sbjct: 1540 QPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTA 1599
Query: 379 --AGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQ-----KDPGESLGMTVAGGAS 431
S P + S+ P + + + E ++ + K P + + G+
Sbjct: 1600 LLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSG 1659
Query: 432 HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVL 491
+ + P + + L N+ VS++++ ++ +
Sbjct: 1660 EDD-------LVTAPANISNSTWSSALHQTLSNM-------VSQAQSHHEAPKSQEDTIC 1705
Query: 492 KALEVKEYEPQEDCSSPAALDSNHNMAPP-----------SDWSPSWVM----------- 529
Y PQ+ + P DSN + PP S+ + S M
Sbjct: 1706 TMF----YYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEP 1761
Query: 530 -----WLELPRCLYNCKD---------IVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSI 575
W L L N + I L ++ GSLGF + G N ++ +
Sbjct: 1762 TRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKG----NQRIGCYVHDV 1817
Query: 576 VEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTI 624
++ PA +DGR++ GD L+ VN + M H LL+ + L I
Sbjct: 1818 IQ-DPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVI 1865
Score = 62.0 bits (149), Expect = 2e-09
Identities = 46/169 (27%), Positives = 74/169 (43%), Gaps = 20/169 (11%)
Query: 342 RYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPL 401
+ + +S A L ++ ERR H S + +S+G+ S++ PL
Sbjct: 1020 KLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLGMTMHSSGN--------SSSQVPL 1071
Query: 402 HPTITCHEK------------VVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGV 449
H++ +VN++KD LG + GG DL I++ SV PGG
Sbjct: 1072 KENDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGP 1131
Query: 450 ISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKE 498
DG +K GD L++V+ V L VS A+ +L+ + L + KE
Sbjct: 1132 ADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKE 1180
Score = 47.8 bits (112), Expect = 3e-05
Identities = 53/243 (21%), Positives = 99/243 (40%), Gaps = 45/243 (18%)
Query: 292 SPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAH 351
S + LG + + G ++ +V+ A G+L+ DR++ +N D+ + A +
Sbjct: 1794 SEKGSLGFTVTKGNQRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNMTHTDAVN 1852
Query: 352 LIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHP----TITC 407
L++A+ + V LV+ R + E P H T+TC
Sbjct: 1853 LLRAASKTVRLVIGRVL------------------------ELPRIPMLPHLLPDITLTC 1888
Query: 408 HEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDG 467
++ E LG ++ GG H +Y+ + P V + +G ++ D++ V+G
Sbjct: 1889 NK----------EELGFSLCGG--HDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNG 1936
Query: 468 VELTEVSRSEAVALLKRTSSSIVLKA----LEVKEYEPQEDCSSPAALDSNHNMAPPSDW 523
V ++ E L + S+VLKA L V + S+P + N + + S
Sbjct: 1937 VSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCS 1996
Query: 524 SPS 526
P+
Sbjct: 1997 QPA 1999
Score = 47.4 bits (111), Expect = 4e-05
Identities = 27/80 (33%), Positives = 42/80 (52%)
Query: 545 LRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGM 604
L+++ LGF I+GG + + FI S+ G PA DG ++ GD L++VN S G+
Sbjct: 1096 LKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGV 1155
Query: 605 IHACLARLLKELKGRITLTI 624
H +L+ +TL I
Sbjct: 1156 SHHAAIEILQNAPEDVTLVI 1175
Score = 47.0 bits (110), Expect = 5e-05
Identities = 54/219 (24%), Positives = 88/219 (40%), Gaps = 42/219 (19%)
Query: 386 SWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVE 445
+W+P + N + + E ++ + K SLG TV G + YV V
Sbjct: 1766 NWTPLKNDLENHLEDFELEV---ELLITLIKSEKGSLGFTVTKGNQR----IGCYVHDVI 1818
Query: 446 PGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDC 505
S DGR+K GD L+ V+ ++T ++ ++AV LL+ S ++ L V E
Sbjct: 1819 QDPAKS-DGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELP----- 1872
Query: 506 SSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYN 565
+P + DI L N LGF + GG++
Sbjct: 1873 --------------------------RIPMLPHLLPDITLTCNKE-ELGFSLCGGHDSLY 1905
Query: 566 GNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGM 604
+ +I I + A +G ++ D++ VNG ST GM
Sbjct: 1906 --QVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGM 1942
Score = 43.5 bits (101), Expect = 6e-04
Identities = 56/218 (25%), Positives = 89/218 (40%), Gaps = 29/218 (13%)
Query: 203 VHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMRE 262
VH +IQ + DGRL PGD ++KVN D++N+ H AV LLR + + L + R
Sbjct: 1814 VHDVIQDPAKS-----DGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRV 1868
Query: 263 QKFRSRNNGQAPDAYRPRDDSF-HVI--LNKSSPEEQLGIKLVRKVDE--PGVFIFNVLD 317
+ PR H++ + + +E+LG L D V+I ++
Sbjct: 1869 LEL-------------PRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINP 1915
Query: 318 GGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQ 377
VA G L+ D + +NG + + E + S + L +R P +
Sbjct: 1916 RSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKR 1975
Query: 378 EA-----GWNSNGSWSPGP-GERSNTPKPLHPTITCHE 409
A NGS+S G + + TP T+ E
Sbjct: 1976 SAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEE 2013
Score = 31.6 bits (70), Expect = 2.3
Identities = 24/70 (34%), Positives = 32/70 (45%), Gaps = 7/70 (10%)
Query: 165 PRLYHLIPDGEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLP 224
P L HL+PD +T K E L L GG ++ + I I V A +G L
Sbjct: 1875 PMLPHLLPDITLTCNK-------EELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQL 1927
Query: 225 GDIILKVNGM 234
D+I VNG+
Sbjct: 1928 LDVIHYVNGV 1937
>gi|223890252 glutamate receptor interacting protein 1 [Homo
sapiens]
Length = 1076
Score = 74.3 bits (181), Expect = 3e-13
Identities = 91/345 (26%), Positives = 143/345 (41%), Gaps = 52/345 (15%)
Query: 185 DPSESLSIRLVGG---SETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPH 241
DP I+L G +ET +I +I D R G L GD ++ +NG+ +
Sbjct: 426 DPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTF 485
Query: 242 NYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKL 301
A +LLR +T+ E +F ++ P +FHV L K E LGI +
Sbjct: 486 EEASQLLRDSSITSKVTL--EIEF------DVAESVIPSSGTFHVKLPKKHNVE-LGITI 536
Query: 302 ----VRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASE 357
RK +P + I ++ G VA+R G LE D++LAI+ L S E A ++Q E
Sbjct: 537 SSPSSRKPGDP-LVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCE 595
Query: 358 RRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKD 417
V L + + N G T + K
Sbjct: 596 DLVKLKIRKD--------------EDNSDEQESSGAIIYTVE---------------LKR 626
Query: 418 PGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSE 477
G LG+T++G + +D PI + S+ GG+ R G I GD +L ++ L SE
Sbjct: 627 YGGPLGITISG--TEEPFD-PIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSE 683
Query: 478 AVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSD 522
A+ LL+ ++ LK +K+ + SSP + +++ D
Sbjct: 684 AIHLLQMAGETVTLK---IKKQTDAQSASSPKKFPISSHLSDLGD 725
Score = 73.6 bits (179), Expect = 5e-13
Identities = 60/215 (27%), Positives = 96/215 (44%), Gaps = 34/215 (15%)
Query: 411 VVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVEL 470
VV + K G +LG+TV+GG D V ++ GG+ +R ++ GD + V+G+ L
Sbjct: 53 VVELMKKEGTTLGLTVSGGIDK---DGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINL 109
Query: 471 TEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMW 530
+ E ++LLK +VL+ EYE PP S V
Sbjct: 110 AKFRHDEIISLLKNVGERVVLEV----EYE-----------------LPPVSVQGSSV-- 146
Query: 531 LELPRCLYNCKDIVLRRNTAGSLGFCIVGG-YEEYNGNKPFFIKSIVEGTPAYNDGRIRC 589
++ ++ L + + GF I GG +++ N ++P I + G PA +G I+
Sbjct: 147 ------IFRTVEVTLHKE-GNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKP 199
Query: 590 GDILLAVNGRSTSGMIHACLARLLKELKGRITLTI 624
GD LL+V+G G HA +LK+ L I
Sbjct: 200 GDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLI 234
Score = 67.4 bits (163), Expect = 4e-11
Identities = 75/304 (24%), Positives = 122/304 (40%), Gaps = 64/304 (21%)
Query: 321 AYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAG 380
A R G L+ DRV+AING + E A+ L++ S + S+ + D+ +
Sbjct: 460 AERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSS-----ITSKVTLEIEFDVAE--- 511
Query: 381 WNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIY 440
S P G T H V + K LG+T++ +S + D P+
Sbjct: 512 -----SVIPSSG-------------TFH---VKLPKKHNVELGITISSPSSRKPGD-PLV 549
Query: 441 VISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYE 500
+ ++ G V R G ++ GD LL +D + L S +AV +L++ + LK + ++
Sbjct: 550 ISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDEDNS 609
Query: 501 PQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGG 560
+++ S + +EL R G LG I G
Sbjct: 610 DEQESSGAI------------------IYTVELKRY-------------GGPLGITISGT 638
Query: 561 YEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRI 620
E ++ P I S+ +G A G I GD +LA+N S G + LL+ +
Sbjct: 639 EEPFD---PIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETV 695
Query: 621 TLTI 624
TL I
Sbjct: 696 TLKI 699
Score = 60.5 bits (145), Expect = 5e-09
Identities = 94/462 (20%), Positives = 176/462 (38%), Gaps = 80/462 (17%)
Query: 207 IQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFR 266
+ ++ + G+ AR +L GD I VNG++++ H+ + LL+ + + L V E
Sbjct: 80 VSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVEYELPPV 139
Query: 267 SRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQ 326
S +R + + H N + G R P V I V GG A R G
Sbjct: 140 SVQGSSV--IFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRP-VVITCVRPGGPADREGT 196
Query: 327 LEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGS 386
++ DR+L+++G L + A +++ + L++ V + +
Sbjct: 197 IKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMD-----------SVA 245
Query: 387 WSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEP 446
+ GP +V + K PG SLG+ + + I + ++
Sbjct: 246 TASGP------------------LLVEVAKTPGASLGVALTTSMCCNKQ--VIVIDKIKS 285
Query: 447 GGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCS 506
+ R G + GD +L++DG + + +EA L T+ + L+ L ++ +
Sbjct: 286 ASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEIL--PHHQTRLALK 343
Query: 507 SP---AALDSNHNMAPPSDWSPSWVMWLELPRCLYNCK---------------------- 541
P A + S+ + S +S S + LPR LY+
Sbjct: 344 GPDHAALVSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLA 403
Query: 542 ----------------DIVLRRNTAGSLGFCIVGG-YEEYNGNKPFFIKSIVEGTPAYND 584
++VL + G + G + + P I I +PA
Sbjct: 404 SSTVGLAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERC 463
Query: 585 GRIRCGDILLAVNGRSTSGMIHACLARLLKE--LKGRITLTI 624
G ++ GD ++A+NG T ++LL++ + ++TL I
Sbjct: 464 GVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLEI 505
Score = 46.6 bits (109), Expect = 7e-05
Identities = 90/464 (19%), Positives = 166/464 (35%), Gaps = 85/464 (18%)
Query: 205 IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQK 264
++I + G R+G + PGD +L V+G+ + H A+ +L+Q Q L +
Sbjct: 180 VVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLI----- 234
Query: 265 FRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKV--DEPGVFIFNVLDGGVAY 322
+ D+ V + K +P LG+ L + ++ + I + +A
Sbjct: 235 ---EYDVSVMDSVATASGPLLVEVAK-TPGASLGVALTTSMCCNKQVIVIDKIKSASIAD 290
Query: 323 RHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVV----SRQVRQRSPD---- 374
R G L D +L+I+G + Y + A + + +V L + ++ + PD
Sbjct: 291 RCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGPDHAAL 350
Query: 375 IFQEAGWNSNGSWSPGPGERSNTPKPLHPT------------------------------ 404
+ S ++S P+ L+ T
Sbjct: 351 VSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLA 410
Query: 405 ---ITCHEKVVNIQKDPGESLGMTVAGGASHRE-WDLPIYVISVEPGGVISRDGRIKTGD 460
+ V + DP G+ + G E P + +E R G ++ GD
Sbjct: 411 GQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGD 470
Query: 461 ILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPP 520
++ ++G+ TE S E + L R SS LE++ D ++ P
Sbjct: 471 RVMAINGIP-TEDSTFEEASQLLRDSSITSKVTLEIE-------------FDVAESVIPS 516
Query: 521 SDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTP 580
S ++LP+ + N LG I G+ P I I +G+
Sbjct: 517 SG-----TFHVKLPK----------KHNV--ELGITISSPSSRKPGD-PLVISDIKKGSV 558
Query: 581 AYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTI 624
A+ G + GD LLA++ ++L++ + + L I
Sbjct: 559 AHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKI 602
>gi|218505835 membrane-associated guanylate kinase-related 3
isoform 1 [Homo sapiens]
Length = 1481
Score = 71.2 bits (173), Expect = 3e-12
Identities = 58/210 (27%), Positives = 103/210 (49%), Gaps = 16/210 (7%)
Query: 423 GMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALL 482
G V GG D IY+ ++ P G +DGR++ D L+ +DG+ + S + + L+
Sbjct: 737 GFRVLGGDGP---DQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLM 793
Query: 483 KRTSSS-----IVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCL 537
+ + V + + E +P++D S A S N +P + + V P+
Sbjct: 794 TTAARNGHVLLTVRRKIFYGEKQPEDDSSQ--AFISTQNGSPRLNRAE--VPARPAPQEP 849
Query: 538 YNCKDIVLRRNTAGSLGFCIVGGYEEYN-GNKPFFIKSIVEGTPAYNDGRIRCGDILLAV 596
Y D+VL+R GF I+ + G P I ++EG+PA G+++ GD + AV
Sbjct: 850 Y---DVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAV 906
Query: 597 NGRSTSGMIHACLARLLKELKGRITLTIVS 626
NG+S + H + +L+K+ +TLT+++
Sbjct: 907 NGQSIVELSHDNIVQLIKDAGVTVTLTVIA 936
Score = 69.3 bits (168), Expect = 1e-11
Identities = 86/371 (23%), Positives = 142/371 (38%), Gaps = 57/371 (15%)
Query: 307 EPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVH--LVV 364
+ ++I ++ G A + G+L D ++ I+G ++ S + L+ + R H L V
Sbjct: 747 DQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTV 806
Query: 365 SRQV----RQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGE 420
R++ +Q D Q NGS E P P P V +Q+ E
Sbjct: 807 RRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPAPQEPYD------VVLQRKENE 860
Query: 421 SLGMTVAGGASHREWD-LPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAV 479
G + + +P + V G R G++K GD + V+G + E+S V
Sbjct: 861 GFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIV 920
Query: 480 ALLKRTSSSIVLKALEVKEYEPQEDCSSPA------------------------ALDSNH 515
L+K ++ L + +E+ ++ A AL+
Sbjct: 921 QLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEI 980
Query: 516 NMAPPSDWSPSWVMWLELPR----------CLYN----CKDIVLRRNTAGSLGFCIVGGY 561
+ + SW L + +N C + L R G GF + GG
Sbjct: 981 GKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPRG-FGFSLRGG- 1038
Query: 562 EEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRIT 621
+EYN FI + E PA DGRI GD ++ +NG T G+ H L++ ++
Sbjct: 1039 KEYNMG--LFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVL 1096
Query: 622 LTIVSWPGTFL 632
L + PGT L
Sbjct: 1097 LLL--RPGTGL 1105
Score = 58.5 bits (140), Expect = 2e-08
Identities = 75/375 (20%), Positives = 147/375 (39%), Gaps = 92/375 (24%)
Query: 193 RLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPC 252
R++GG + P I I I G +DGRL D ++ ++G+ + H + L+
Sbjct: 739 RVLGG-DGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAA 797
Query: 253 QV--LWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILN---------------KSSPEE 295
+ + LTV R+ + + +P DDS ++ + +P+E
Sbjct: 798 RNGHVLLTVRRKIFYGEK---------QPEDDSSQAFISTQNGSPRLNRAEVPARPAPQE 848
Query: 296 QLGIKLVRKVDE--------------PGVF---IFNVLDGGVAYRHGQLEENDRVLAING 338
+ L RK +E PGV I V++G A R G+L+ D + A+NG
Sbjct: 849 PYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNG 908
Query: 339 HDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSP------------------------- 373
+ S ++ LI+ + V L V + P
Sbjct: 909 QSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANH 968
Query: 374 ----------DIFQEAGWNSNGSWS-------PGPGERSNTPKPLHPTITCHEKVVNIQK 416
+I ++ + SWS P S + + C+ V +++
Sbjct: 969 IPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYP--VELER 1026
Query: 417 DPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRS 476
P G ++ GG +E+++ ++++ + G +DGRI GD ++ ++G ++ +
Sbjct: 1027 GP-RGFGFSLRGG---KEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHT 1082
Query: 477 EAVALLKRTSSSIVL 491
A+ L++ + ++L
Sbjct: 1083 RAIELIQAGGNKVLL 1097
Score = 40.4 bits (93), Expect = 0.005
Identities = 21/70 (30%), Positives = 41/70 (58%), Gaps = 4/70 (5%)
Query: 545 LRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGM 604
L+++T G GF I+GG ++ +K++++ PA DG+I GD+++ +NG G
Sbjct: 413 LKKSTMG-FGFTIIGGDRP---DEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGH 468
Query: 605 IHACLARLLK 614
HA + ++ +
Sbjct: 469 THADVVQMFQ 478
Score = 38.5 bits (88), Expect = 0.019
Identities = 15/53 (28%), Positives = 32/53 (60%)
Query: 197 GSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLR 249
G + P + ++++ +DG A+DG++ PGD+I+ +NG + H V++ +
Sbjct: 426 GGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQ 478
Score = 35.0 bits (79), Expect = 0.21
Identities = 32/140 (22%), Positives = 52/140 (37%), Gaps = 21/140 (15%)
Query: 130 RALSVLRRTKSGSAVANHADQGRENSENTTAPEVFPRLYH--------LIPDGEITSIKI 181
R L+ G + ANH R E +V H PD + S+
Sbjct: 951 RQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVG 1010
Query: 182 NRVDPS------------ESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIIL 229
+R + + L GG E + + I + DG +DGR+ GD I+
Sbjct: 1011 SRHNQNLGCYPVELERGPRGFGFSLRGGKEYNM-GLFILRLAEDGPAIKDGRIHVGDQIV 1069
Query: 230 KVNGMDISNVPHNYAVRLLR 249
++NG + H A+ L++
Sbjct: 1070 EINGEPTQGITHTRAIELIQ 1089
Score = 30.4 bits (67), Expect = 5.2
Identities = 27/101 (26%), Positives = 47/101 (46%), Gaps = 7/101 (6%)
Query: 399 KPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGG----VISRDG 454
K H E V+ PG+ G + GGA E+ + + EPGG V+S
Sbjct: 7 KKKHWLSKVQECAVSWAGPPGD-FGAEIRGGAERGEFPY-LGRLREEPGGGTCCVVSGKA 64
Query: 455 RIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALE 495
GD+LL V+G ++ ++ + +A+++ I LK ++
Sbjct: 65 P-SPGDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVK 104
>gi|155969695 membrane-associated guanylate kinase-related 3
isoform 2 [Homo sapiens]
Length = 1125
Score = 71.2 bits (173), Expect = 3e-12
Identities = 58/210 (27%), Positives = 103/210 (49%), Gaps = 16/210 (7%)
Query: 423 GMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALL 482
G V GG D IY+ ++ P G +DGR++ D L+ +DG+ + S + + L+
Sbjct: 737 GFRVLGGDGP---DQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLM 793
Query: 483 KRTSSS-----IVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCL 537
+ + V + + E +P++D S A S N +P + + V P+
Sbjct: 794 TTAARNGHVLLTVRRKIFYGEKQPEDDSSQ--AFISTQNGSPRLNRAE--VPARPAPQEP 849
Query: 538 YNCKDIVLRRNTAGSLGFCIVGGYEEYN-GNKPFFIKSIVEGTPAYNDGRIRCGDILLAV 596
Y D+VL+R GF I+ + G P I ++EG+PA G+++ GD + AV
Sbjct: 850 Y---DVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAV 906
Query: 597 NGRSTSGMIHACLARLLKELKGRITLTIVS 626
NG+S + H + +L+K+ +TLT+++
Sbjct: 907 NGQSIVELSHDNIVQLIKDAGVTVTLTVIA 936
Score = 69.3 bits (168), Expect = 1e-11
Identities = 86/371 (23%), Positives = 142/371 (38%), Gaps = 57/371 (15%)
Query: 307 EPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVH--LVV 364
+ ++I ++ G A + G+L D ++ I+G ++ S + L+ + R H L V
Sbjct: 747 DQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTV 806
Query: 365 SRQV----RQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGE 420
R++ +Q D Q NGS E P P P V +Q+ E
Sbjct: 807 RRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPAPQEPYD------VVLQRKENE 860
Query: 421 SLGMTVAGGASHREWD-LPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAV 479
G + + +P + V G R G++K GD + V+G + E+S V
Sbjct: 861 GFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIV 920
Query: 480 ALLKRTSSSIVLKALEVKEYEPQEDCSSPA------------------------ALDSNH 515
L+K ++ L + +E+ ++ A AL+
Sbjct: 921 QLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEI 980
Query: 516 NMAPPSDWSPSWVMWLELPR----------CLYN----CKDIVLRRNTAGSLGFCIVGGY 561
+ + SW L + +N C + L R G GF + GG
Sbjct: 981 GKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPRG-FGFSLRGG- 1038
Query: 562 EEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRIT 621
+EYN FI + E PA DGRI GD ++ +NG T G+ H L++ ++
Sbjct: 1039 KEYNMG--LFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVL 1096
Query: 622 LTIVSWPGTFL 632
L + PGT L
Sbjct: 1097 LLL--RPGTGL 1105
Score = 58.5 bits (140), Expect = 2e-08
Identities = 75/375 (20%), Positives = 147/375 (39%), Gaps = 92/375 (24%)
Query: 193 RLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPC 252
R++GG + P I I I G +DGRL D ++ ++G+ + H + L+
Sbjct: 739 RVLGG-DGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAA 797
Query: 253 QV--LWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILN---------------KSSPEE 295
+ + LTV R+ + + +P DDS ++ + +P+E
Sbjct: 798 RNGHVLLTVRRKIFYGEK---------QPEDDSSQAFISTQNGSPRLNRAEVPARPAPQE 848
Query: 296 QLGIKLVRKVDE--------------PGVF---IFNVLDGGVAYRHGQLEENDRVLAING 338
+ L RK +E PGV I V++G A R G+L+ D + A+NG
Sbjct: 849 PYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNG 908
Query: 339 HDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSP------------------------- 373
+ S ++ LI+ + V L V + P
Sbjct: 909 QSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANH 968
Query: 374 ----------DIFQEAGWNSNGSWS-------PGPGERSNTPKPLHPTITCHEKVVNIQK 416
+I ++ + SWS P S + + C+ V +++
Sbjct: 969 IPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYP--VELER 1026
Query: 417 DPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRS 476
P G ++ GG +E+++ ++++ + G +DGRI GD ++ ++G ++ +
Sbjct: 1027 GP-RGFGFSLRGG---KEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHT 1082
Query: 477 EAVALLKRTSSSIVL 491
A+ L++ + ++L
Sbjct: 1083 RAIELIQAGGNKVLL 1097
Score = 40.4 bits (93), Expect = 0.005
Identities = 21/70 (30%), Positives = 41/70 (58%), Gaps = 4/70 (5%)
Query: 545 LRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGM 604
L+++T G GF I+GG ++ +K++++ PA DG+I GD+++ +NG G
Sbjct: 413 LKKSTMG-FGFTIIGGDRP---DEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGH 468
Query: 605 IHACLARLLK 614
HA + ++ +
Sbjct: 469 THADVVQMFQ 478
Score = 38.5 bits (88), Expect = 0.019
Identities = 15/53 (28%), Positives = 32/53 (60%)
Query: 197 GSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLR 249
G + P + ++++ +DG A+DG++ PGD+I+ +NG + H V++ +
Sbjct: 426 GGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQ 478
Score = 35.0 bits (79), Expect = 0.21
Identities = 32/140 (22%), Positives = 52/140 (37%), Gaps = 21/140 (15%)
Query: 130 RALSVLRRTKSGSAVANHADQGRENSENTTAPEVFPRLYH--------LIPDGEITSIKI 181
R L+ G + ANH R E +V H PD + S+
Sbjct: 951 RQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVG 1010
Query: 182 NRVDPS------------ESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIIL 229
+R + + L GG E + + I + DG +DGR+ GD I+
Sbjct: 1011 SRHNQNLGCYPVELERGPRGFGFSLRGGKEYNM-GLFILRLAEDGPAIKDGRIHVGDQIV 1069
Query: 230 KVNGMDISNVPHNYAVRLLR 249
++NG + H A+ L++
Sbjct: 1070 EINGEPTQGITHTRAIELIQ 1089
Score = 30.4 bits (67), Expect = 5.2
Identities = 27/101 (26%), Positives = 47/101 (46%), Gaps = 7/101 (6%)
Query: 399 KPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGG----VISRDG 454
K H E V+ PG+ G + GGA E+ + + EPGG V+S
Sbjct: 7 KKKHWLSKVQECAVSWAGPPGD-FGAEIRGGAERGEFPY-LGRLREEPGGGTCCVVSGKA 64
Query: 455 RIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALE 495
GD+LL V+G ++ ++ + +A+++ I LK ++
Sbjct: 65 P-SPGDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVK 104
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 69.3 bits (168), Expect = 1e-11
Identities = 115/504 (22%), Positives = 190/504 (37%), Gaps = 91/504 (18%)
Query: 172 PDGEITSIKINRVDPSESLSIRLVGGSETPLVH--IIIQHIYRDGVIARDGRLLPGDIIL 229
P+ EIT + + + D L +++GG + + I I + G DG L PGD ++
Sbjct: 1087 PEREITLVNLKK-DAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLI 1145
Query: 230 KVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSR------------NNGQAPDAY 277
VN + + V H+ A+ +L+ + + L + + ++ S+ N +Y
Sbjct: 1146 SVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSY 1205
Query: 278 RPRDDSFHVILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEEND------ 331
DS ++ SS + +R + E N R G L D
Sbjct: 1206 --MQDS---AIDSSSKDHHWSRGTLRHISE------NSFGPSGGLREGSLSSQDSRTESA 1254
Query: 332 --RVLAING-----------HDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQE 378
+NG + ++GSP S + + +A+E+ S Q + + P I
Sbjct: 1255 SLSQSQVNGFFASHLGDQTWQESQHGSP-SPSVISKATEKET-FTDSNQSKTKKPGISDV 1312
Query: 379 AGWNSNGSWSPGPGERSN-----TPKPLHPTITCHEKVVNIQ------KDPGE------- 420
++ G S+ TPK + +N + PG+
Sbjct: 1313 TDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELA 1372
Query: 421 ----SLGMTVA-----GGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELT 471
SLG++V GG + IYV +V P G DGRI GD +L V+GV L
Sbjct: 1373 KNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLE 1432
Query: 472 EVSRSEAVALLKRTSSSIVL-----KALEVKEY---EPQEDCSSPAALDSNHNMAPPSDW 523
+ +AV L+ T + L ++ KE+ PQ S A +
Sbjct: 1433 GATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQ 1492
Query: 524 SPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIV---GGYEEYNGNKPFFIKSIVEGTP 580
+ E N ++ L +N++G LGF E +K + G P
Sbjct: 1493 VKDYSFVTE-----ENTFEVKLFKNSSG-LGFSFSREDNLIPEQINASIVRVKKLFPGQP 1546
Query: 581 AYNDGRIRCGDILLAVNGRSTSGM 604
A G+I GD++L VNG S G+
Sbjct: 1547 AAESGKIDVGDVILKVNGASLKGL 1570
Score = 69.3 bits (168), Expect = 1e-11
Identities = 110/532 (20%), Positives = 201/532 (37%), Gaps = 106/532 (19%)
Query: 174 GEITSIKINRVDPSESLSIRLV---GGSETPLVH--IIIQHIYRDGVIARDGRLLPGDII 228
G+I +++ + D S +S+ ++ GG T + H I ++ + G DGR+ GD +
Sbjct: 1364 GDIFEVELAKNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRV 1423
Query: 229 LKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNN---------------GQA 273
L VNG+ + H AV LR QV+ L + + Q S+ + GQ
Sbjct: 1424 LAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQG 1483
Query: 274 PD-----------AYRPRDDSFHVILNKSSPEEQLGIKLVR-------KVDEPGVFIFNV 315
P+ ++ +++F V L K+S LG R +++ V + +
Sbjct: 1484 PEKVKKTTQVKDYSFVTEENTFEVKLFKNS--SGLGFSFSREDNLIPEQINASIVRVKKL 1541
Query: 316 LDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDI 375
G A G+++ D +L +NG L+ S + ++ + V L++ R P+I
Sbjct: 1542 FPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEI 1601
Query: 376 FQE--AGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQ-----KDPGESLGMTVAG 428
S P + S+ P + + + E ++ + K P + +
Sbjct: 1602 DTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSS 1661
Query: 429 GASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSS 488
G+ + + P + + L N+ VS++++ ++
Sbjct: 1662 GSGEDD-------LVTAPANISNSTWSSALHQTLSNM-------VSQAQSHHEAPKSQED 1707
Query: 489 IVLKALEVKEYEPQEDCSSPAALDSNHNMAPP-----------SDWSPSWVM-------- 529
+ Y PQ+ + P DSN + PP S+ + S M
Sbjct: 1708 TICTMF----YYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHI 1763
Query: 530 --------WLELPRCLYNCKD---------IVLRRNTAGSLGFCIVGGYEEYNGNKPFFI 572
W L L N + I L ++ GSLGF + G N ++
Sbjct: 1764 SEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKG----NQRIGCYV 1819
Query: 573 KSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTI 624
+++ PA +DGR++ GD L+ VN + M H LL+ + L I
Sbjct: 1820 HDVIQ-DPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVI 1870
Score = 62.0 bits (149), Expect = 2e-09
Identities = 46/169 (27%), Positives = 74/169 (43%), Gaps = 20/169 (11%)
Query: 342 RYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPL 401
+ + +S A L ++ ERR H S + +S+G+ S++ PL
Sbjct: 1020 KLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLGMTMHSSGN--------SSSQVPL 1071
Query: 402 HPTITCHEK------------VVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGV 449
H++ +VN++KD LG + GG DL I++ SV PGG
Sbjct: 1072 KENDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGP 1131
Query: 450 ISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKE 498
DG +K GD L++V+ V L VS A+ +L+ + L + KE
Sbjct: 1132 ADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKE 1180
Score = 47.8 bits (112), Expect = 3e-05
Identities = 53/243 (21%), Positives = 99/243 (40%), Gaps = 45/243 (18%)
Query: 292 SPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAH 351
S + LG + + G ++ +V+ A G+L+ DR++ +N D+ + A +
Sbjct: 1799 SEKGSLGFTVTKGNQRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNMTHTDAVN 1857
Query: 352 LIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHP----TITC 407
L++A+ + V LV+ R + E P H T+TC
Sbjct: 1858 LLRAASKTVRLVIGRVL------------------------ELPRIPMLPHLLPDITLTC 1893
Query: 408 HEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDG 467
++ E LG ++ GG H +Y+ + P V + +G ++ D++ V+G
Sbjct: 1894 NK----------EELGFSLCGG--HDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNG 1941
Query: 468 VELTEVSRSEAVALLKRTSSSIVLKA----LEVKEYEPQEDCSSPAALDSNHNMAPPSDW 523
V ++ E L + S+VLKA L V + S+P + N + + S
Sbjct: 1942 VSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCS 2001
Query: 524 SPS 526
P+
Sbjct: 2002 QPA 2004
Score = 47.4 bits (111), Expect = 4e-05
Identities = 27/80 (33%), Positives = 42/80 (52%)
Query: 545 LRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGM 604
L+++ LGF I+GG + + FI S+ G PA DG ++ GD L++VN S G+
Sbjct: 1096 LKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGV 1155
Query: 605 IHACLARLLKELKGRITLTI 624
H +L+ +TL I
Sbjct: 1156 SHHAAIEILQNAPEDVTLVI 1175
Score = 47.0 bits (110), Expect = 5e-05
Identities = 54/219 (24%), Positives = 88/219 (40%), Gaps = 42/219 (19%)
Query: 386 SWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVE 445
+W+P + N + + E ++ + K SLG TV G + YV V
Sbjct: 1771 NWTPLKNDLENHLEDFELEV---ELLITLIKSEKGSLGFTVTKGNQR----IGCYVHDVI 1823
Query: 446 PGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDC 505
S DGR+K GD L+ V+ ++T ++ ++AV LL+ S ++ L V E
Sbjct: 1824 QDPAKS-DGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELP----- 1877
Query: 506 SSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYN 565
+P + DI L N LGF + GG++
Sbjct: 1878 --------------------------RIPMLPHLLPDITLTCNKE-ELGFSLCGGHDSLY 1910
Query: 566 GNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGM 604
+ +I I + A +G ++ D++ VNG ST GM
Sbjct: 1911 --QVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGM 1947
Score = 43.5 bits (101), Expect = 6e-04
Identities = 56/218 (25%), Positives = 89/218 (40%), Gaps = 29/218 (13%)
Query: 203 VHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMRE 262
VH +IQ + DGRL PGD ++KVN D++N+ H AV LLR + + L + R
Sbjct: 1819 VHDVIQDPAKS-----DGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRV 1873
Query: 263 QKFRSRNNGQAPDAYRPRDDSF-HVI--LNKSSPEEQLGIKLVRKVDE--PGVFIFNVLD 317
+ PR H++ + + +E+LG L D V+I ++
Sbjct: 1874 LEL-------------PRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINP 1920
Query: 318 GGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQ 377
VA G L+ D + +NG + + E + S + L +R P +
Sbjct: 1921 RSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKR 1980
Query: 378 EA-----GWNSNGSWSPGP-GERSNTPKPLHPTITCHE 409
A NGS+S G + + TP T+ E
Sbjct: 1981 SAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEE 2018
Score = 31.6 bits (70), Expect = 2.3
Identities = 24/70 (34%), Positives = 32/70 (45%), Gaps = 7/70 (10%)
Query: 165 PRLYHLIPDGEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLP 224
P L HL+PD +T K E L L GG ++ + I I V A +G L
Sbjct: 1880 PMLPHLLPDITLTCNK-------EELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQL 1932
Query: 225 GDIILKVNGM 234
D+I VNG+
Sbjct: 1933 LDVIHYVNGV 1942
>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform a [Homo sapiens]
Length = 1287
Score = 67.0 bits (162), Expect = 5e-11
Identities = 98/433 (22%), Positives = 168/433 (38%), Gaps = 80/433 (18%)
Query: 261 REQKFRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDEPG--VFIFNVLDG 318
RE++ S N G+ P D F + K E G +++ +EPG ++I +++
Sbjct: 820 REREINSTNFGECPIPDYQEQDIF--LWRK---ETGFGFRILGG-NEPGEPIYIGHIVPL 873
Query: 319 GVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQ--ASERRVHLVVSRQV-------- 368
G A G+L D ++ ++G + S + L+Q A + V+L V R+V
Sbjct: 874 GAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTE 933
Query: 369 ---------------------RQRSPDIFQEA-GWNSNGSWSP-GPGERSNTPKPLHPTI 405
+R+P Q + S+GS S G G + T+
Sbjct: 934 NEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTV 993
Query: 406 TCHEKVVNIQKDPGESLGMTVAGGASHREWD---------LPIYVISVEPGGVISRDGRI 456
V I++ E G + S E +P + + G R G++
Sbjct: 994 V-QPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKL 1052
Query: 457 KTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHN 516
K GD +L V+G +T S S+ V L+K +++ L+ + P ++ S+ L +
Sbjct: 1053 KVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRII------PGDESSNATLLTNAEK 1106
Query: 517 MAP------PSDWSPSWVMWLELPR--CLYNCK-----------DIVLRRNTAGSLGFCI 557
+A PS P+ + K + L R G GF +
Sbjct: 1107 IATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKG-FGFSL 1165
Query: 558 VGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELK 617
GG E N ++ + E PA G++R GD +L +NG +T M H+ L+K
Sbjct: 1166 RGGREY---NMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGG 1222
Query: 618 GRITLTIVSWPGT 630
R+ L + G+
Sbjct: 1223 RRVRLFLKRGDGS 1235
Score = 63.5 bits (153), Expect = 6e-10
Identities = 81/310 (26%), Positives = 120/310 (38%), Gaps = 59/310 (19%)
Query: 370 QRSPDIF----QEAGWNSNGSWSPGP------GERSNTPKPLH----PTITCHEKVVNI- 414
Q+ PD F Q N SP P GER + P E+ + +
Sbjct: 786 QKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGECPIPDYQEQDIFLW 845
Query: 415 QKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVS 474
+K+ G G + GG E PIY+ + P G DGR+++GD L+ VDG + S
Sbjct: 846 RKETG--FGFRILGGNEPGE---PIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKS 900
Query: 475 RSEAVALLKRTSSS---------IVLKALEVKEYEPQEDCSS------PAALDSNHNMAP 519
V L+++ + V+ A+ E E SS PA+L
Sbjct: 901 HQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQ 960
Query: 520 PSDWSPSWVM---------------WLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEY 564
S S + V + + D+ +RR GF IV
Sbjct: 961 GSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRP 1020
Query: 565 N-----GNK----PFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKE 615
GN P I I+EG+PA G+++ GD +LAVNG S + H+ + L+KE
Sbjct: 1021 EAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKE 1080
Query: 616 LKGRITLTIV 625
+TL I+
Sbjct: 1081 AGNTVTLRII 1090
Score = 45.8 bits (107), Expect = 1e-04
Identities = 31/100 (31%), Positives = 50/100 (50%), Gaps = 8/100 (8%)
Query: 399 KPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVE----PGGVISRDG 454
K H T HE +++ P LG+TV GGA H E+ V +VE PGG
Sbjct: 7 KKNHWTSRVHE--CTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGG--GEGP 62
Query: 455 RIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKAL 494
R+ G++LL V GV ++ + R + + ++ ++ KA+
Sbjct: 63 RLGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAV 102
Score = 42.7 bits (99), Expect = 0.001
Identities = 32/132 (24%), Positives = 60/132 (45%), Gaps = 14/132 (10%)
Query: 148 ADQGRENSENTTAPEVFPRLYHLIPDG----EITSIKINRVDPSESLSIRLVGGSETPLV 203
+ QG + + NTT P+ + P + ++++ R S+R GG E +
Sbjct: 1117 SQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLR--GGREYNM- 1173
Query: 204 HIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQ 263
+ + + DG R G++ GD IL++NG N+ H+ A+ L++ + R +
Sbjct: 1174 DLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGR-------RVR 1226
Query: 264 KFRSRNNGQAPD 275
F R +G P+
Sbjct: 1227 LFLKRGDGSVPE 1238
Score = 41.2 bits (95), Expect = 0.003
Identities = 24/72 (33%), Positives = 42/72 (58%), Gaps = 4/72 (5%)
Query: 545 LRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGM 604
LR+++ G GF +VGG E ++ IKS+V PA DG++ GD++++VN G
Sbjct: 475 LRKSSRG-FGFTVVGGDEP---DEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGH 530
Query: 605 IHACLARLLKEL 616
HA + ++ + +
Sbjct: 531 THAQVVKIFQSI 542
Score = 40.8 bits (94), Expect = 0.004
Identities = 42/184 (22%), Positives = 72/184 (39%), Gaps = 35/184 (19%)
Query: 218 RDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVM------------REQKF 265
R G+L GD IL VNG I+N H+ V L+++ + L ++ +K
Sbjct: 1048 RCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKI 1107
Query: 266 RSRNNGQAP---------DAYRPRDDSFHVILNKSSPEEQ--LGIKLVRKVDEPG----- 309
+ P + +P+ +S + +EQ ++L R G
Sbjct: 1108 ATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRG 1167
Query: 310 -------VFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHL 362
+++ + + G A R G++ D +L ING + A LI+ RRV L
Sbjct: 1168 GREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRL 1227
Query: 363 VVSR 366
+ R
Sbjct: 1228 FLKR 1231
Score = 38.5 bits (88), Expect = 0.019
Identities = 32/97 (32%), Positives = 48/97 (49%), Gaps = 5/97 (5%)
Query: 171 IPDGEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILK 230
IPD + I + R + R++GG+E P I I HI G DGRL GD ++
Sbjct: 834 IPDYQEQDIFLWRKETG--FGFRILGGNE-PGEPIYIGHIVPLGAADTDGRLRSGDELIC 890
Query: 231 VNGMDISNVPHNYAVRLLRQPCQV--LWLTVMREQKF 265
V+G + H V+L++Q + + LTV R+ F
Sbjct: 891 VDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVF 927
Score = 33.1 bits (74), Expect = 0.80
Identities = 19/63 (30%), Positives = 31/63 (49%), Gaps = 1/63 (1%)
Query: 187 SESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVR 246
S +VGG E P + I+ + DG A DG++ GD+I+ VN + H V+
Sbjct: 479 SRGFGFTVVGGDE-PDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVK 537
Query: 247 LLR 249
+ +
Sbjct: 538 IFQ 540
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,180,700
Number of Sequences: 37866
Number of extensions: 1258857
Number of successful extensions: 4434
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 140
Number of HSP's successfully gapped in prelim test: 52
Number of HSP's that attempted gapping in prelim test: 3341
Number of HSP's gapped (non-prelim): 921
length of query: 632
length of database: 18,247,518
effective HSP length: 108
effective length of query: 524
effective length of database: 14,157,990
effective search space: 7418786760
effective search space used: 7418786760
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.