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Search of human proteins with 171184400
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|171184400 ATP-binding cassette, sub-family B, member 10
[Homo sapiens]
(738 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 1449 0.0
gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo ... 421 e-117
gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member ... 403 e-112
gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member... 403 e-112
gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member ... 361 2e-99
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 350 3e-96
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 349 6e-96
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C... 349 6e-96
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A... 349 6e-96
gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Ho... 338 1e-92
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 334 2e-91
gi|73747915 transporter 2, ATP-binding cassette, sub-family B is... 322 8e-88
gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ... 310 4e-84
gi|73747917 transporter 2, ATP-binding cassette, sub-family B is... 293 4e-79
gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo sa... 239 7e-63
gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo s... 225 1e-58
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member... 182 1e-45
gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor... 177 3e-44
gi|134142342 ATP-binding cassette, sub-family C, member 1 isofor... 177 3e-44
gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor... 177 3e-44
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor... 177 3e-44
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ... 172 1e-42
gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo ... 168 2e-41
gi|89111135 ATP-binding cassette protein C12 [Homo sapiens] 167 2e-41
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ... 167 3e-41
gi|110832837 ATP-binding cassette, sub-family C, member 9 isofor... 166 9e-41
gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor... 164 4e-40
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens] 163 5e-40
gi|110832839 ATP-binding cassette, sub-family C, member 9 isofor... 159 1e-38
gi|110832835 ATP-binding cassette, sub-family C, member 9 isofor... 159 1e-38
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 1449 bits (3752), Expect = 0.0
Identities = 738/738 (100%), Positives = 738/738 (100%)
Query: 1 MRGPPAWPLRLLEPPSPAEPGRLLPVACVWAAASRVPGSLSPFTGLRPARLWGAGPALLW 60
MRGPPAWPLRLLEPPSPAEPGRLLPVACVWAAASRVPGSLSPFTGLRPARLWGAGPALLW
Sbjct: 1 MRGPPAWPLRLLEPPSPAEPGRLLPVACVWAAASRVPGSLSPFTGLRPARLWGAGPALLW 60
Query: 61 GVGAARRWRSGCRGGGPGASRGVLGLARLLGLWARGPGSCRCGAFAGPGAPRLPRARFPG 120
GVGAARRWRSGCRGGGPGASRGVLGLARLLGLWARGPGSCRCGAFAGPGAPRLPRARFPG
Sbjct: 61 GVGAARRWRSGCRGGGPGASRGVLGLARLLGLWARGPGSCRCGAFAGPGAPRLPRARFPG 120
Query: 121 GPAAAAWAGDEAWRRGPAAPPGDKGRLRPAAAGLPEARKLLGLAYPERRRLAAAVGFLTM 180
GPAAAAWAGDEAWRRGPAAPPGDKGRLRPAAAGLPEARKLLGLAYPERRRLAAAVGFLTM
Sbjct: 121 GPAAAAWAGDEAWRRGPAAPPGDKGRLRPAAAGLPEARKLLGLAYPERRRLAAAVGFLTM 180
Query: 181 SSVISMSAPFFLGKIIDVIYTNPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTSG 240
SSVISMSAPFFLGKIIDVIYTNPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTSG
Sbjct: 181 SSVISMSAPFFLGKIIDVIYTNPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTSG 240
Query: 241 QRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQA 300
QRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQA
Sbjct: 241 QRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQA 300
Query: 301 SVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGN 360
SVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGN
Sbjct: 301 SVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGN 360
Query: 361 VRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLL 420
VRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLL
Sbjct: 361 VRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLL 420
Query: 421 MGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEG 480
MGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEG
Sbjct: 421 MGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEG 480
Query: 481 VILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLL 540
VILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLL
Sbjct: 481 VILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLL 540
Query: 541 LRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTA 600
LRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTA
Sbjct: 541 LRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTA 600
Query: 601 EEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEA 660
EEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEA
Sbjct: 601 EEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEA 660
Query: 661 TSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLS 720
TSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLS
Sbjct: 661 TSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLS 720
Query: 721 KPNGIYRKLMNKQSFISA 738
KPNGIYRKLMNKQSFISA
Sbjct: 721 KPNGIYRKLMNKQSFISA 738
>gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo
sapiens]
Length = 718
Score = 421 bits (1083), Expect = e-117
Identities = 232/575 (40%), Positives = 357/575 (62%), Gaps = 10/575 (1%)
Query: 165 YPERRRLAAAVGFLTMSSVISMSAPFFLGKIIDVIYTNPTVDYSDNLTRLCLGLSAVFLC 224
+P L AV ++++++ P LG++++V+ T D+ + LS L
Sbjct: 125 HPHLLVLGVAVVLALGAALVNVQIPLLLGQLVEVV-AKYTRDHVGSFMTESQNLSTHLLI 183
Query: 225 GAAANAIRVY----LMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTA 280
+ + L+ G+R+ +R +LFSS+LRQ++ FFD +TG+L++RL++D
Sbjct: 184 LYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQ 243
Query: 281 LLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLT 340
S +S GLR+ Q + + + +S L ++ P + + + G LRKL+
Sbjct: 244 EFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLS 303
Query: 341 KVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFG 400
+ Q+ +A+A +A+E +GNVRTVRAF E E E+Y ++++ A + A F G
Sbjct: 304 RQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQG 363
Query: 401 ATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLG 460
+ ++ N +VL L+ GG L+ +T G+L SFL+ + V S+ LS + ++++GL
Sbjct: 364 LSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLS 423
Query: 461 AGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSG 520
AG R++E + P +P + G + ++ +G++ F+NV F+YP RP + +DF+L++P G
Sbjct: 424 AGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPG 483
Query: 521 SVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSK-IGTVSQEPIL 579
+ ALVG SG GK+TV SLL R YDP +G + LDG D+R L+P WLR + +G +SQEP+L
Sbjct: 484 KIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVL 543
Query: 580 FSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQK 639
F +I ENI +G + S EE+ A ANA FI +FP+G+NTVVGE+G LSGGQK
Sbjct: 544 FGTTIMENIRFGKLEASD---EEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQK 600
Query: 640 QRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNAN 699
QR+AIARAL+K P +L+LDEATSALDAE+E +VQEALDR GRTVLVIAHRLST++ A+
Sbjct: 601 QRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAH 660
Query: 700 MVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQS 734
+ V+ G++ E G HEELL K G+Y +L+ +Q+
Sbjct: 661 CIVVMADGRVWEAGTHEELLKK-GGLYAELIRRQA 694
>gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 403 bits (1036), Expect = e-112
Identities = 234/594 (39%), Positives = 364/594 (61%), Gaps = 12/594 (2%)
Query: 141 PGDKGRLRPAAAGLPEARKLLGLAYPERRRLAAAVGFLTMSSVISMSAPFFLGKIIDVIY 200
PG GR P A +KLL P+ L AA FL ++++ P++ G+ ID I
Sbjct: 159 PGS-GRPPPEQASGATLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIV 217
Query: 201 TNPTVD-YSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQE 259
++D +S + +CL + + + A IR + R+ RLR LF S++ QE
Sbjct: 218 IQKSMDQFSTAVVIVCL----LAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQE 273
Query: 260 VAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVL 319
+FFD+ RTG+LI+RL+SDT ++ V++N++ LR + + + MF +S L+
Sbjct: 274 TSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTF 333
Query: 320 SVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYAS 379
P + +++ IYG+Y ++L+K Q++LA+A+ AEE I ++TVR+F E E E Y
Sbjct: 334 MGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLR 393
Query: 380 KVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAF 439
K+ V +L RKEA A + +GL+ ++ +S+LY GG L+ S MT G L +F++Y F
Sbjct: 394 KLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEF 453
Query: 440 WVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHF 499
+G + + S YS LM+G+GA +++E ++R+P + + L +G ++F+NV F
Sbjct: 454 VLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGS--LAPDHLEGRVDFENVTF 511
Query: 500 AYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIR 559
Y RP + Q+ S S+ G VTALVGPSGSGKS+ +++L Y G + LDG I
Sbjct: 512 TYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPIS 571
Query: 560 QLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNF 619
+ +L I VSQEP+LF+ SI +NI+YG +V E + A+ ANA FI
Sbjct: 572 AYDHKYLHRVISLVSQEPVLFARSITDNISYGL---PTVPFEMVVEAAQKANAHGFIMEL 628
Query: 620 PQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRL 679
G++T GEKG LSGGQKQR+A+ARAL++NP +L+LDEATSALDAE+EYL+Q+A+
Sbjct: 629 QDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGN 688
Query: 680 MDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQ 733
+ TVL+IAHRLST+++A+++ VLD+G++ + G H++LL++ G+Y KL+ +Q
Sbjct: 689 LQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ-GGLYAKLVQRQ 741
>gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 403 bits (1036), Expect = e-112
Identities = 234/594 (39%), Positives = 364/594 (61%), Gaps = 12/594 (2%)
Query: 141 PGDKGRLRPAAAGLPEARKLLGLAYPERRRLAAAVGFLTMSSVISMSAPFFLGKIIDVIY 200
PG GR P A +KLL P+ L AA FL ++++ P++ G+ ID I
Sbjct: 159 PGS-GRPPPEQASGATLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIV 217
Query: 201 TNPTVD-YSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQE 259
++D +S + +CL + + + A IR + R+ RLR LF S++ QE
Sbjct: 218 IQKSMDQFSTAVVIVCL----LAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQE 273
Query: 260 VAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVL 319
+FFD+ RTG+LI+RL+SDT ++ V++N++ LR + + + MF +S L+
Sbjct: 274 TSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTF 333
Query: 320 SVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYAS 379
P + +++ IYG+Y ++L+K Q++LA+A+ AEE I ++TVR+F E E E Y
Sbjct: 334 MGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLR 393
Query: 380 KVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAF 439
K+ V +L RKEA A + +GL+ ++ +S+LY GG L+ S MT G L +F++Y F
Sbjct: 394 KLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEF 453
Query: 440 WVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHF 499
+G + + S YS LM+G+GA +++E ++R+P + + L +G ++F+NV F
Sbjct: 454 VLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGS--LAPDHLEGRVDFENVTF 511
Query: 500 AYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIR 559
Y RP + Q+ S S+ G VTALVGPSGSGKS+ +++L Y G + LDG I
Sbjct: 512 TYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPIS 571
Query: 560 QLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNF 619
+ +L I VSQEP+LF+ SI +NI+YG +V E + A+ ANA FI
Sbjct: 572 AYDHKYLHRVISLVSQEPVLFARSITDNISYGL---PTVPFEMVVEAAQKANAHGFIMEL 628
Query: 620 PQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRL 679
G++T GEKG LSGGQKQR+A+ARAL++NP +L+LDEATSALDAE+EYL+Q+A+
Sbjct: 629 QDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGN 688
Query: 680 MDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQ 733
+ TVL+IAHRLST+++A+++ VLD+G++ + G H++LL++ G+Y KL+ +Q
Sbjct: 689 LQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ-GGLYAKLVQRQ 741
>gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 2 [Homo sapiens]
Length = 723
Score = 361 bits (926), Expect = 2e-99
Identities = 222/594 (37%), Positives = 339/594 (57%), Gaps = 55/594 (9%)
Query: 141 PGDKGRLRPAAAGLPEARKLLGLAYPERRRLAAAVGFLTMSSVISMSAPFFLGKIIDVIY 200
PG GR P A +KLL P+ L AA FL ++++ P++ G+ ID I
Sbjct: 159 PGS-GRPPPEQASGATLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIV 217
Query: 201 TNPTVD-YSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQE 259
++D +S + +CL + + + A IR + R+ RLR LF S++ QE
Sbjct: 218 IQKSMDQFSTAVVIVCL----LAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQE 273
Query: 260 VAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVL 319
+FFD+ RTG+LI+RL+SDT ++ V++N++ LR + + + MF +S L+
Sbjct: 274 TSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTF 333
Query: 320 SVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYAS 379
P + +++ IYG+Y ++L+K Q++LA+A+ AEE I ++TVR+F E E E Y
Sbjct: 334 MGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLR 393
Query: 380 KVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAF 439
K+ V +L RKEA A MY
Sbjct: 394 KLQQVYKLNRKEAAA----------------------------------------YMYYV 413
Query: 440 WVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHF 499
W S+G S YS LM+G+GA +++E ++R+P + + L +G ++F+NV F
Sbjct: 414 WGSGSVG---SVYSGLMQGVGAAEKVFEFIDRQPTMVHDGS--LAPDHLEGRVDFENVTF 468
Query: 500 AYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIR 559
Y RP + Q+ S S+ G VTALVGPSGSGKS+ +++L Y G + LDG I
Sbjct: 469 TYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPIS 528
Query: 560 QLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNF 619
+ +L I VSQEP+LF+ SI +NI+YG +V E + A+ ANA FI
Sbjct: 529 AYDHKYLHRVISLVSQEPVLFARSITDNISYGLP---TVPFEMVVEAAQKANAHGFIMEL 585
Query: 620 PQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRL 679
G++T GEKG LSGGQKQR+A+ARAL++NP +L+LDEATSALDAE+EYL+Q+A+
Sbjct: 586 QDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGN 645
Query: 680 MDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQ 733
+ TVL+IAHRLST+++A+++ VLD+G++ + G H++LL++ G+Y KL+ +Q
Sbjct: 646 LQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ-GGLYAKLVQRQ 698
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 350 bits (898), Expect = 3e-96
Identities = 215/585 (36%), Positives = 325/585 (55%), Gaps = 19/585 (3%)
Query: 152 AGLPEARKLLGLAYPERRRLAAAVGFLT--MSSVISMSAPFFLGKIIDVIYTNPTVDYSD 209
AGLP L+ L + E + A G L MS++ + S D+ T ++ +
Sbjct: 63 AGLP----LMMLVFGEMTDIFANAGNLEDLMSNITNRS---------DINDTGFFMNLEE 109
Query: 210 NLTRLCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTG 269
++TR S + A I+V + R ++++R F +I+RQE+ +FD G
Sbjct: 110 DMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVG 169
Query: 270 ELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIA 329
EL RL+ D + + + + + ++ A G + F L +L++ P + + A
Sbjct: 170 ELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSA 229
Query: 330 VIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLAR 389
++ + L T + A+A +AEE + +RTV AFG + E+E+Y ++ ++
Sbjct: 230 AVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGI 289
Query: 390 KEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLS 449
K+A GA L + G L+ S ++G++ + S+G S
Sbjct: 290 KKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQAS 349
Query: 450 SFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPI 509
GA ++++++ +P + + +G LEF+NVHF+YP+R EV I
Sbjct: 350 PSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKI 409
Query: 510 FQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSK 569
+ +L + SG ALVG SG GKST + L+ RLYDP G +S+DG DIR +N +LR
Sbjct: 410 LKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREI 469
Query: 570 IGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGE 629
IG VSQEP+LF+ +IAENI YG ++ VT +EI++ + ANA FI P F+T+VGE
Sbjct: 470 IGVVSQEPVLFATTIAENIRYGREN---VTMDEIEKAVKEANAYDFIMKLPHKFDTLVGE 526
Query: 630 KGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIA 689
+G LSGGQKQRIAIARAL++NPKILLLDEATSALD E+E +VQ ALD+ GRT +VIA
Sbjct: 527 RGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIA 586
Query: 690 HRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQS 734
HRLST++NA+++A D G I E G H+EL+ K GIY KL+ Q+
Sbjct: 587 HRLSTVRNADVIAGFDDGVIVEKGNHDELM-KEKGIYFKLVTMQT 630
Score = 335 bits (858), Expect = 1e-91
Identities = 203/504 (40%), Positives = 303/504 (60%), Gaps = 16/504 (3%)
Query: 239 SGQRIVNRLRTSLFSSILRQEVAFFD--KTRTGELINRLSSDTALLGRSVTENLSDGLRA 296
+G+ + RLR +F S+LRQ+V++FD K TG L RL++D A + ++ L+ +
Sbjct: 780 AGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQN 839
Query: 297 GAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEE 356
A GI + F L +L++VP ++I V+ + L + L + ++A E
Sbjct: 840 IANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATE 899
Query: 357 RIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYK 416
I N RTV + +T+ +K+ +Q+ + + +A FG T S ++ Y
Sbjct: 900 AIENFRTVVS----LTQEQKFEHMYAQSLQVPYRNSLRKAHIFGIT-FSFTQAMMYFSYA 954
Query: 417 GGLLMGSAHMTVGELSSF----LMYAFWV--GISIGGLSSFYSELMKGLGAGGRLWELLE 470
G G A++ +L SF L+++ V +++G +SSF + K + + ++E
Sbjct: 955 GCFRFG-AYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIE 1013
Query: 471 REPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSG 530
+ P + L + +G + F V F YP RP++P+ Q SL + G ALVG SG
Sbjct: 1014 KTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSG 1073
Query: 531 SGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAY 590
GKSTV+ LL R YDP +G + LDG +I++LN WLR+ +G VSQEPILF CSIAENIAY
Sbjct: 1074 CGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAY 1133
Query: 591 GADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLK 650
G D+ V+ EEI R A+ AN AFI + P ++T VG+KG LSGGQKQRIAIARAL++
Sbjct: 1134 G-DNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVR 1192
Query: 651 NPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKIT 710
P ILLLDEATSALD E+E +VQEALD+ +GRT +VIAHRLSTI+NA+++ V G++
Sbjct: 1193 QPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVK 1252
Query: 711 EYGKHEELLSKPNGIYRKLMNKQS 734
E+G H++LL++ GIY +++ Q+
Sbjct: 1253 EHGTHQQLLAQ-KGIYFSMVSVQA 1275
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 349 bits (895), Expect = 6e-96
Identities = 204/533 (38%), Positives = 299/533 (56%), Gaps = 4/533 (0%)
Query: 202 NPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVA 261
NP + +TR S + A I+V + R + ++R F +ILRQE+
Sbjct: 104 NPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIG 163
Query: 262 FFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSV 321
+FD T EL RL+ D + + + + + +A A G + F L ++++
Sbjct: 164 WFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAI 223
Query: 322 VPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKV 381
P + + A ++ + L + + A+A +AEE +G +RTV AFG + E+E+Y +
Sbjct: 224 SPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHL 283
Query: 382 DHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWV 441
++ ++ K+A + G L + G L+ S T+G +
Sbjct: 284 ENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIG 343
Query: 442 GISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAY 501
S+G + GA ++++++ PK+ S +G LEF +VHF+Y
Sbjct: 344 AFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSY 403
Query: 502 PARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQL 561
P+R V I + +L + SG ALVG SG GKST + L+ RLYDP GTI++DG DIR
Sbjct: 404 PSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNF 463
Query: 562 NPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQ 621
N +LR IG VSQEP+LFS +IAENI YG +VT +EI++ + ANA FI PQ
Sbjct: 464 NVNYLREIIGVVSQEPVLFSTTIAENICYGR---GNVTMDEIKKAVKEANAYEFIMKLPQ 520
Query: 622 GFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMD 681
F+T+VGE+G LSGGQKQRIAIARAL++NPKILLLDEATSALD E+E VQ ALD+ +
Sbjct: 521 KFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKARE 580
Query: 682 GRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQS 734
GRT +VIAHRLST++NA+++A + G I E G H EL+ K G+Y KL+N Q+
Sbjct: 581 GRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKK-EGVYFKLVNMQT 632
Score = 323 bits (828), Expect = 4e-88
Identities = 198/509 (38%), Positives = 293/509 (57%), Gaps = 19/509 (3%)
Query: 239 SGQRIVNRLRTSLFSSILRQEVAFFD--KTRTGELINRLSSDTALLGRSVTENLSDGLRA 296
+G+ + RLR+ F ++LRQ++++FD K TG L RL++D A + + L+ +
Sbjct: 779 AGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQN 838
Query: 297 GAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEE 356
A GI + F L +L+VVP +++ ++ + L K + L A ++A E
Sbjct: 839 IANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATE 898
Query: 357 RIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGAT-GLSGNLIVLSV-- 413
I N+RTV + +T+ K+ S + + + +A +G T +S + S
Sbjct: 899 AIENIRTVVS----LTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAG 954
Query: 414 -LYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLERE 472
G L+ + HM ++ + +++G SSF + K + L+ L ER+
Sbjct: 955 CFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQ 1014
Query: 473 PKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSG 532
P + L F+G + F V F YP R VP+ Q SL + G ALVG SG G
Sbjct: 1015 PLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCG 1074
Query: 533 KSTVLSLLLRLYDPASGTIS-------LDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIA 585
KSTV+ LL R YDP +GT+ LDG + ++LN WLR+++G VSQEPILF CSIA
Sbjct: 1075 KSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIA 1134
Query: 586 ENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIA 645
ENIAYG D+ V+ +EI A+ AN FI P + T VG+KG LSGGQKQRIAIA
Sbjct: 1135 ENIAYG-DNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIA 1193
Query: 646 RALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLD 705
RAL++ P+ILLLDEATSALD E+E +VQEALD+ +GRT +VIAHRLSTI+NA+++ V
Sbjct: 1194 RALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQ 1253
Query: 706 QGKITEYGKHEELLSKPNGIYRKLMNKQS 734
G++ E+G H++LL++ GIY +++ Q+
Sbjct: 1254 NGRVKEHGTHQQLLAQ-KGIYFSMVSVQA 1281
>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
[Homo sapiens]
Length = 1232
Score = 349 bits (895), Expect = 6e-96
Identities = 204/533 (38%), Positives = 299/533 (56%), Gaps = 4/533 (0%)
Query: 202 NPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVA 261
NP + +TR S + A I+V + R + ++R F +ILRQE+
Sbjct: 104 NPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIG 163
Query: 262 FFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSV 321
+FD T EL RL+ D + + + + + +A A G + F L ++++
Sbjct: 164 WFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAI 223
Query: 322 VPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKV 381
P + + A ++ + L + + A+A +AEE +G +RTV AFG + E+E+Y +
Sbjct: 224 SPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHL 283
Query: 382 DHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWV 441
++ ++ K+A + G L + G L+ S T+G +
Sbjct: 284 ENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIG 343
Query: 442 GISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAY 501
S+G + GA ++++++ PK+ S +G LEF +VHF+Y
Sbjct: 344 AFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSY 403
Query: 502 PARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQL 561
P+R V I + +L + SG ALVG SG GKST + L+ RLYDP GTI++DG DIR
Sbjct: 404 PSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNF 463
Query: 562 NPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQ 621
N +LR IG VSQEP+LFS +IAENI YG +VT +EI++ + ANA FI PQ
Sbjct: 464 NVNYLREIIGVVSQEPVLFSTTIAENICYGR---GNVTMDEIKKAVKEANAYEFIMKLPQ 520
Query: 622 GFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMD 681
F+T+VGE+G LSGGQKQRIAIARAL++NPKILLLDEATSALD E+E VQ ALD+ +
Sbjct: 521 KFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKARE 580
Query: 682 GRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQS 734
GRT +VIAHRLST++NA+++A + G I E G H EL+ K G+Y KL+N Q+
Sbjct: 581 GRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKK-EGVYFKLVNMQT 632
Score = 317 bits (811), Expect = 3e-86
Identities = 195/498 (39%), Positives = 276/498 (55%), Gaps = 51/498 (10%)
Query: 239 SGQRIVNRLRTSLFSSILRQEVAFFD--KTRTGELINRLSSDTALLGRSVTENLSDGLRA 296
+G+ + RLR+ F ++LRQ++++FD K TG L RL++D A + + L+ +
Sbjct: 779 AGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQN 838
Query: 297 GAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEE 356
A GI + F L +L+VVP +++ ++ + L K + L A ++A E
Sbjct: 839 IANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATE 898
Query: 357 RIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYK 416
I N+RTV + +E Y K L G V S +
Sbjct: 899 AIENIRTVVSLTQERKFESMYVEK-----------------------LYGPYRVFSAIVF 935
Query: 417 GGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLP 476
G + +G A SSF + K + L+ L ER+P +
Sbjct: 936 GAVALGHA------------------------SSFAPDYAKAKLSAAHLFMLFERQPLID 971
Query: 477 FNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTV 536
L F+G + F V F YP R VP+ Q SL + G ALVG SG GKSTV
Sbjct: 972 SYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTV 1031
Query: 537 LSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPS 596
+ LL R YDP +GT+ LDG + ++LN WLR+++G VSQEPILF CSIAENIAYG D+
Sbjct: 1032 VQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYG-DNSR 1090
Query: 597 SVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILL 656
V+ +EI A+ AN FI P + T VG+KG LSGGQKQRIAIARAL++ P+ILL
Sbjct: 1091 VVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILL 1150
Query: 657 LDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHE 716
LDEATSALD E+E +VQEALD+ +GRT +VIAHRLSTI+NA+++ V G++ E+G H+
Sbjct: 1151 LDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQ 1210
Query: 717 ELLSKPNGIYRKLMNKQS 734
+LL++ GIY +++ Q+
Sbjct: 1211 QLLAQ-KGIYFSMVSVQA 1227
>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
[Homo sapiens]
Length = 1279
Score = 349 bits (895), Expect = 6e-96
Identities = 204/533 (38%), Positives = 299/533 (56%), Gaps = 4/533 (0%)
Query: 202 NPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVA 261
NP + +TR S + A I+V + R + ++R F +ILRQE+
Sbjct: 104 NPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIG 163
Query: 262 FFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSV 321
+FD T EL RL+ D + + + + + +A A G + F L ++++
Sbjct: 164 WFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAI 223
Query: 322 VPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKV 381
P + + A ++ + L + + A+A +AEE +G +RTV AFG + E+E+Y +
Sbjct: 224 SPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHL 283
Query: 382 DHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWV 441
++ ++ K+A + G L + G L+ S T+G +
Sbjct: 284 ENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIG 343
Query: 442 GISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAY 501
S+G + GA ++++++ PK+ S +G LEF +VHF+Y
Sbjct: 344 AFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSY 403
Query: 502 PARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQL 561
P+R V I + +L + SG ALVG SG GKST + L+ RLYDP GTI++DG DIR
Sbjct: 404 PSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNF 463
Query: 562 NPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQ 621
N +LR IG VSQEP+LFS +IAENI YG +VT +EI++ + ANA FI PQ
Sbjct: 464 NVNYLREIIGVVSQEPVLFSTTIAENICYGR---GNVTMDEIKKAVKEANAYEFIMKLPQ 520
Query: 622 GFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMD 681
F+T+VGE+G LSGGQKQRIAIARAL++NPKILLLDEATSALD E+E VQ ALD+ +
Sbjct: 521 KFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKARE 580
Query: 682 GRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQS 734
GRT +VIAHRLST++NA+++A + G I E G H EL+ K G+Y KL+N Q+
Sbjct: 581 GRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKK-EGVYFKLVNMQT 632
Score = 330 bits (846), Expect = 3e-90
Identities = 198/502 (39%), Positives = 293/502 (58%), Gaps = 12/502 (2%)
Query: 239 SGQRIVNRLRTSLFSSILRQEVAFFD--KTRTGELINRLSSDTALLGRSVTENLSDGLRA 296
+G+ + RLR+ F ++LRQ++++FD K TG L RL++D A + + L+ +
Sbjct: 779 AGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQN 838
Query: 297 GAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEE 356
A GI + F L +L+VVP +++ ++ + L K + L A ++A E
Sbjct: 839 IANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATE 898
Query: 357 RIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGAT-GLSGNLIVLSV-- 413
I N+RTV + +T+ K+ S + + + +A +G T +S + S
Sbjct: 899 AIENIRTVVS----LTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAG 954
Query: 414 -LYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLERE 472
G L+ + HM ++ + +++G SSF + K + L+ L ER+
Sbjct: 955 CFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQ 1014
Query: 473 PKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSG 532
P + L F+G + F V F YP R VP+ Q SL + G ALVG SG G
Sbjct: 1015 PLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCG 1074
Query: 533 KSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGA 592
KSTV+ LL R YDP +GT+ LDG + ++LN WLR+++G VSQEPILF CSIAENIAYG
Sbjct: 1075 KSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYG- 1133
Query: 593 DDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNP 652
D+ V+ +EI A+ AN FI P + T VG+KG LSGGQKQRIAIARAL++ P
Sbjct: 1134 DNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQP 1193
Query: 653 KILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEY 712
+ILLLDEATSALD E+E +VQEALD+ +GRT +VIAHRLSTI+NA+++ V G++ E+
Sbjct: 1194 QILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEH 1253
Query: 713 GKHEELLSKPNGIYRKLMNKQS 734
G H++LL++ GIY +++ Q+
Sbjct: 1254 GTHQQLLAQ-KGIYFSMVSVQA 1274
>gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Homo
sapiens]
Length = 808
Score = 338 bits (866), Expect = 1e-92
Identities = 246/748 (32%), Positives = 386/748 (51%), Gaps = 48/748 (6%)
Query: 2 RGPPAWPLRLLEPPSPAEPGRLLPVACVWA----AASRVPGSLSPFTGLRPARLWGAGP- 56
R P R L S A G +L + W A R+ L P T L R+W G
Sbjct: 65 RCPAPRGCRCLPGASLAWLGTVLLLLADWVLLRTALPRIFSLLVP-TALPLLRVWAVGLS 123
Query: 57 --ALLW----GVGAARRWRSGCRGGGPGASRGVLGLARLLGLWARGPGSCR-CGAFAGPG 109
A+LW GV A G G + LA LGL G R ++ PG
Sbjct: 124 RWAVLWLGACGVLRATVGSKSENAGAQGWLAALKPLAAALGLALPGLALFRELISWGAPG 183
Query: 110 APRLPRARFPGG-------------PAAAAWAGDEAWRRGPAAPPGDKGRLRPAAAGLPE 156
+ R G PAAA W + G PG +G +G P
Sbjct: 184 SADSTRLLHWGSHPTAFVVSYAAALPAAALWH-----KLGSLWVPGGQG-----GSGNP- 232
Query: 157 ARKLLGLAYPERRRLAAAVGFLTMSSVISMSAPFFLGKIIDVIYTNPTVD-YSDNLTRLC 215
R+LLG E RRL+ + + +SS+ M+ PFF G++ D I + + D ++ NLT +
Sbjct: 233 VRRLLGCLGSETRRLSLFLVLVVLSSLGEMAIPFFTGRLTDWILQDGSADTFTRNLTLM- 291
Query: 216 LGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRL 275
S + + A + + + + + L+ +F ++LRQE FF + +TG +++R+
Sbjct: 292 ---SILTIASAVLEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTGNIMSRV 348
Query: 276 SSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRY 335
+ DT+ L S++ENLS L + + +M + S +L L +P + ++ G++
Sbjct: 349 TEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKW 408
Query: 336 LRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFAR 395
+ L ++SLA+++Q+A E + + TVR+F E E +K+ K+ + L +KEA A
Sbjct: 409 YQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAY 468
Query: 396 AGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSEL 455
A T +SG L+ + +LY GG L+ S ++ G L +F++Y ++ L S Y +
Sbjct: 469 AVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRV 528
Query: 456 MKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSL 515
K +G+ +++E L+R P+ P +L +G ++F++V FAYP RP+V + Q +
Sbjct: 529 QKAVGSSEKIFEYLDRTPRCP--PSGLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTF 586
Query: 516 SIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQ 575
++ G VTALVGP+GSGKSTV +LL LY P G + LDG + Q +L ++ V Q
Sbjct: 587 TLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQ 646
Query: 576 EPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLS 635
EP +F S+ ENIAYG T EEI A + A +FI PQG++T V E G LS
Sbjct: 647 EPQVFGRSLQENIAYGL--TQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLS 704
Query: 636 GGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMD--GRTVLVIAHRLS 693
GGQ+Q +A+ARAL++ P +L+LD+ATSALDA ++ V++ L + R+VL+I LS
Sbjct: 705 GGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLS 764
Query: 694 TIKNANMVAVLDQGKITEYGKHEELLSK 721
++ A+ + L+ G I E G H++L+ K
Sbjct: 765 LVEQADHILFLEGGAIREGGTHQQLMEK 792
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 334 bits (857), Expect = 2e-91
Identities = 197/508 (38%), Positives = 284/508 (55%), Gaps = 11/508 (2%)
Query: 231 IRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENL 290
I++ + R + ++R F I+R E+ +FD GEL R S D + ++ + +
Sbjct: 158 IQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQM 217
Query: 291 SDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQA 350
+ ++ G + FF L ++SV P + I A G + K T + A+A
Sbjct: 218 ALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKA 277
Query: 351 TQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLI- 409
+A+E I ++RTV AFG E E+E+Y + + ++ GFF TG LI
Sbjct: 278 GVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVM-GFF--TGFVWCLIF 334
Query: 410 ---VLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLW 466
L+ Y L++ T G L + +++G S G A ++
Sbjct: 335 LCYALAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIF 394
Query: 467 ELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALV 526
E ++R+P + +G +EF NV F YP+RPEV I D ++ I G +TALV
Sbjct: 395 ETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALV 454
Query: 527 GPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAE 586
GPSG+GKST L L+ R YDP G +++DGHDIR LN WLR +IG V QEP+LFS +IAE
Sbjct: 455 GPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAE 514
Query: 587 NIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIAR 646
NI YG +D T E+I + A+ ANA FI + PQ F+T+VGE G +SGGQKQR+AIAR
Sbjct: 515 NIRYGRED---ATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIAR 571
Query: 647 ALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQ 706
AL++NPKILLLD ATSALD E+E +VQE L ++ G T++ +AHRLST++ A+ + +
Sbjct: 572 ALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEH 631
Query: 707 GKITEYGKHEELLSKPNGIYRKLMNKQS 734
G E G HEELL + G+Y L+ QS
Sbjct: 632 GTAVERGTHEELLER-KGVYFTLVTLQS 658
Score = 305 bits (781), Expect = 1e-82
Identities = 198/584 (33%), Positives = 308/584 (52%), Gaps = 8/584 (1%)
Query: 158 RKLLGLAYPE-RRRLAAAVGFLTMSSVISMSAPFFLGKIIDVIYTNPTVDYSDNLTRLCL 216
R++L + PE L +VG +V + A F +I+ + + +CL
Sbjct: 742 RRILKFSAPEWPYMLVGSVGAAVNGTVTPLYA-FLFSQILGTFSIPDKEEQRSQINGVCL 800
Query: 217 GLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRT--GELINR 274
A+ ++ Y SG+ + RLR F ++L Q++A+FD R G L R
Sbjct: 801 LFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTR 860
Query: 275 LSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGR 334
L++D + + + + + + +V + + F S L+ +L P +++ R
Sbjct: 861 LATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTR 920
Query: 335 YLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFA 394
L + +L Q+ E + N+RTV GKE IE ++++ + A ++A
Sbjct: 921 MLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANI 980
Query: 395 RAGFFGATGLSGNLIVLSVLYK-GGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYS 453
GF A I S Y+ GG L+ + + + + ++G S+
Sbjct: 981 Y-GFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYTP 1039
Query: 454 ELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDF 513
K + R ++LL+R+P + +FQG ++F + F YP+RP+ +
Sbjct: 1040 SYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGL 1099
Query: 514 SLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTV 573
S+SI G A VG SG GKST + LL R YDP G + +DGHD +++N +LRS IG V
Sbjct: 1100 SVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIV 1159
Query: 574 SQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVL 633
SQEP+LF+CSI +NI YG D+ + E + A+ A F+ + P+ + T VG +G
Sbjct: 1160 SQEPVLFACSIMDNIKYG-DNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQ 1218
Query: 634 LSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLS 693
LS G+KQRIAIARA++++PKILLLDEATSALD E+E VQ ALD+ +GRT +VIAHRLS
Sbjct: 1219 LSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLS 1278
Query: 694 TIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQSFIS 737
TI+NA+++AV+ QG + E G HEEL+++ G Y KL+ S IS
Sbjct: 1279 TIQNADIIAVMAQGVVIEKGTHEELMAQ-KGAYYKLVTTGSPIS 1321
>gi|73747915 transporter 2, ATP-binding cassette, sub-family B
isoform 1 [Homo sapiens]
Length = 703
Score = 322 bits (825), Expect = 8e-88
Identities = 221/645 (34%), Positives = 345/645 (53%), Gaps = 20/645 (3%)
Query: 81 RGVLGLAR--LLGLWARGPGSCRCGAFAGPGAPRLPRARFPGGPAAAAWAGDEA----WR 134
RG+LG LL L P + A GA R P AR P + G A W
Sbjct: 56 RGLLGFVGTLLLPLCLATPLTVSLRALVA-GASRAPPARVASAPWSWLLVGYGAAGLSWS 114
Query: 135 RGPA-APPGDKGRLRPAAAGLPEARKLLGLAYPERRRLAAAVGFLTMSSVISMSAPFFLG 193
+PPG + + + +LL L+ P+ L AA FL ++ + P + G
Sbjct: 115 LWAVLSPPGAQEKEQDQVNNKVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYSG 174
Query: 194 KIIDVIYTNPTVDYSDNLTRLCLGLSAVFLCGAAANA-IRVYLMQTSGQRIVNRLRTSLF 252
++ID++ D+ + + +F G++ +A R + RI R+R LF
Sbjct: 175 RVIDILGG----DFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLF 230
Query: 253 SSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSP 312
SS+LRQ++ FF +T+TGEL +RLSSDT L+ + N + LR+ + M +SP
Sbjct: 231 SSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISP 290
Query: 313 NLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMT 372
L L +P +Y +++ + QD++A+A Q+ E +G ++TVR+FG E
Sbjct: 291 RLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEH 350
Query: 373 EIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELS 432
E+ +Y ++ QL + RA + + + + +L G M +T G L
Sbjct: 351 EVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLL 410
Query: 433 SFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGAL 492
SF++Y VG + L Y +++ +GA +++ ++R+P LP + G L + QG +
Sbjct: 411 SFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLP-SPGT-LAPTTLQGVV 468
Query: 493 EFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTIS 552
+F++V FAYP RP+ P+ + + ++ G VTALVGP+GSGKSTV +LL LY P G +
Sbjct: 469 KFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVL 528
Query: 553 LDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANA 612
LD I Q +L S++ +V QEP+LFS S+ NIAYG S +++ A+ A+A
Sbjct: 529 LDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGL---QSCEDDKVMAAAQAAHA 585
Query: 613 VAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLV 672
FI+ G T VGEKG L+ GQKQR+AIARAL+++P++L+LDEATSALD + E +
Sbjct: 586 DDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQAL 645
Query: 673 QEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEE 717
Q+ R RTVLVIAHRL ++ A+ + VL +GK+ + + +E
Sbjct: 646 QDWNSR--GDRTVLVIAHRLQAVQRAHQILVLQEGKLQKLAQLQE 688
>gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
sapiens]
Length = 812
Score = 310 bits (793), Expect = 4e-84
Identities = 188/503 (37%), Positives = 275/503 (54%), Gaps = 14/503 (2%)
Query: 239 SGQRIVNRLRTSLFSSILRQEVAFFDKTR--TGELINRLSSDTALLGRSVTENLSDGLRA 296
+G+ + RLR F ++L Q++A+FD+ TG L L+ D A + + + +
Sbjct: 315 AGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQN 374
Query: 297 GAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEE 356
+ + + F + +LS+ P +++ +I + + L A ++A E
Sbjct: 375 ATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATE 434
Query: 357 RIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYK 416
+ N+RT+ + +E + Y + ++Q + +A G+ + + Y
Sbjct: 435 ALENIRTIVSLTREKAFEQMY----EEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFA-YA 489
Query: 417 GGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSS-----FYSELMKGLGAGGRLWELLER 471
G G+ + G ++ M+ + I+ G ++ E K L+ LLE+
Sbjct: 490 AGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGETLVLAPEYSKAKSGAAHLFALLEK 549
Query: 472 EPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGS 531
+P + + +G LEF+ V F YP RP+V I + SLSI G A VG SG
Sbjct: 550 KPNIDSRSQEGKKPDTCEGNLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGC 609
Query: 532 GKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYG 591
GKST + LL RLYDP G + DG D ++LN WLRS+I V QEP+LF+CSIAENIAYG
Sbjct: 610 GKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYG 669
Query: 592 ADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKN 651
D+ V +EI+ A AN +FI P+ +NT VG KG LSGGQKQR+AIARALL+
Sbjct: 670 -DNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQK 728
Query: 652 PKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITE 711
PKILLLDEATSALD ++E +VQ ALD+ GRT LV+ HRLS I+NA+++ VL GKI E
Sbjct: 729 PKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKE 788
Query: 712 YGKHEELLSKPNGIYRKLMNKQS 734
G H+ELL + IY KL+N QS
Sbjct: 789 QGTHQELL-RNRDIYFKLVNAQS 810
Score = 191 bits (484), Expect = 3e-48
Identities = 102/186 (54%), Positives = 131/186 (70%), Gaps = 4/186 (2%)
Query: 553 LDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANA 612
+D +DIR LN R IG VSQEP+LF +I+ NI YG DD VT EE++R A ANA
Sbjct: 2 VDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDD---VTDEEMERAAREANA 58
Query: 613 VAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLV 672
FI FP FNT+VGEKG +SGGQKQRIAIARAL++NPKIL+LDEATSALD+E++ V
Sbjct: 59 YDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAV 118
Query: 673 QEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNK 732
Q AL++ GRT +V+AHRLSTI++A+++ L G + E G H EL++K G+Y L+
Sbjct: 119 QAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAK-RGLYYSLVMS 177
Query: 733 QSFISA 738
Q A
Sbjct: 178 QDIKKA 183
>gi|73747917 transporter 2, ATP-binding cassette, sub-family B
isoform 2 [Homo sapiens]
Length = 653
Score = 293 bits (750), Expect = 4e-79
Identities = 203/597 (34%), Positives = 316/597 (52%), Gaps = 18/597 (3%)
Query: 81 RGVLGLAR--LLGLWARGPGSCRCGAFAGPGAPRLPRARFPGGPAAAAWAGDEA----WR 134
RG+LG LL L P + A GA R P AR P + G A W
Sbjct: 56 RGLLGFVGTLLLPLCLATPLTVSLRALVA-GASRAPPARVASAPWSWLLVGYGAAGLSWS 114
Query: 135 RGPA-APPGDKGRLRPAAAGLPEARKLLGLAYPERRRLAAAVGFLTMSSVISMSAPFFLG 193
+PPG + + + +LL L+ P+ L AA FL ++ + P + G
Sbjct: 115 LWAVLSPPGAQEKEQDQVNNKVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYSG 174
Query: 194 KIIDVIYTNPTVDYSDNLTRLCLGLSAVFLCGAAANA-IRVYLMQTSGQRIVNRLRTSLF 252
++ID++ D+ + + +F G++ +A R + RI R+R LF
Sbjct: 175 RVIDILGG----DFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLF 230
Query: 253 SSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSP 312
SS+LRQ++ FF +T+TGEL +RLSSDT L+ + N + LR+ + M +SP
Sbjct: 231 SSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISP 290
Query: 313 NLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMT 372
L L +P +Y +++ + QD++A+A Q+ E +G ++TVR+FG E
Sbjct: 291 RLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEH 350
Query: 373 EIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELS 432
E+ +Y ++ QL + RA + + + + +L G M +T G L
Sbjct: 351 EVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLL 410
Query: 433 SFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGAL 492
SF++Y VG + L Y +++ +GA +++ ++R+P LP + G L + QG +
Sbjct: 411 SFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLP-SPGT-LAPTTLQGVV 468
Query: 493 EFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTIS 552
+F++V FAYP RP+ P+ + + ++ G VTALVGP+GSGKSTV +LL LY P G +
Sbjct: 469 KFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVL 528
Query: 553 LDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANA 612
LD I Q +L S++ +V QEP+LFS S+ NIAYG S +++ A+ A+A
Sbjct: 529 LDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGL---QSCEDDKVMAAAQAAHA 585
Query: 613 VAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENE 669
FI+ G T VGEKG L+ GQKQR+AIARAL+++P++L+LDEATSALD + E
Sbjct: 586 DDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCE 642
>gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo
sapiens]
Length = 842
Score = 239 bits (610), Expect = 7e-63
Identities = 173/514 (33%), Positives = 268/514 (52%), Gaps = 28/514 (5%)
Query: 231 IRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENL 290
+R +L Q R+ +FS + + + RTGE++ T+ + ++ +
Sbjct: 329 LRTFLWIRVQQFTSRRVELLIFSHLHELSLRWHLGRRTGEVLRIADRGTSSVTGLLSYLV 388
Query: 291 SDGLRAGAQASVGI---SMMFFVSPNLATFV-LSVVPPVSIIAVIYGRYLRKLTKVTQDS 346
+ + A +GI SM F L F+ +S+ ++I+ + R+ TQ++
Sbjct: 389 FNVIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLTLTIVVTEWRTKFRRAMN-TQEN 447
Query: 347 LAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSG 406
+A A + + N TV+ + E E+E+Y + L K + + +
Sbjct: 448 ATRAR--AVDSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSASLV----LLNQTQ 501
Query: 407 NLIVLSVLYKGGLLMG----SAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAG 462
NL++ L G LL + VG+ F Y + + + ++Y +
Sbjct: 502 NLVIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYRMIQTNFIDM 561
Query: 463 GRLWELLEREPKLPFNEGVILNEKSFQ-GALEFKNVHFAYPARPEVPIFQDFSLSIPSGS 521
+++LL+ E ++ G FQ G +EF+NVHF+Y E QD S ++ G
Sbjct: 562 ENMFDLLKEETEVKDLPGA--GPLRFQKGRIEFENVHFSYADGRET--LQDVSFTVMPGQ 617
Query: 522 VTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFS 581
ALVGPSG+GKST+L LL R YD +SG I +DG DI Q+ LRS IG V Q+ +LF+
Sbjct: 618 TLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFN 677
Query: 582 CSIAENIAYGADDPSSVTA--EEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQK 639
+IA+NI YG VTA +E++ A+ A I FP+G+ T VGE+G+ LSGG+K
Sbjct: 678 DTIADNIRYGR-----VTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEK 732
Query: 640 QRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNAN 699
QR+AIAR +LK P I+LLDEATSALD NE +Q +L ++ RT +V+AHRLST+ NA+
Sbjct: 733 QRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRLSTVVNAD 792
Query: 700 MVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQ 733
+ V+ G I E G+HE LLS+ G+Y + Q
Sbjct: 793 QILVIKDGCIVERGRHEALLSR-GGVYADMWQLQ 825
>gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo
sapiens]
Length = 753
Score = 225 bits (573), Expect = 1e-58
Identities = 170/580 (29%), Positives = 285/580 (49%), Gaps = 20/580 (3%)
Query: 168 RRRLAAAVGFLTMSSVISMSAPFFLGKIIDVI--YTNPTVDYSDNLTRLCLGLSAVFL-- 223
R R+A ++GFL + +++ PF +D + + ++ SD + +AV +
Sbjct: 138 RARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLSDAPNTVATMATAVLIGY 197
Query: 224 ----CGAAA-NAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSD 278
GAA N +R + Q + R+ ++F + ++ F +TG L +
Sbjct: 198 GVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGFHLSRQTGALSKAIDRG 257
Query: 279 TALLGRSVTENLSDGLRAGAQASVGISMMFF-VSPNLATFVLSVVPPVSIIAVIYGRYLR 337
T + ++ + + L + + ++++ A L + + V R+
Sbjct: 258 TRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLGTLGTYTAFTVAVTRWRT 317
Query: 338 KLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYAS--KVDHVMQLARKEAFAR 395
+ + A A + + N TV+ F E E ++Y K L A
Sbjct: 318 RFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGFLKTYETASLKSTSTLAM 377
Query: 396 AGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSEL 455
F + S L + VL G++ G+ +TVG+L F + + + L + Y E
Sbjct: 378 LNFGQSAIFSVGLTAIMVLASQGIVAGT--LTVGDLVMVNGLLFQLSLPLNFLGTVYRET 435
Query: 456 MKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGA-LEFKNVHFAYPARPEVPIFQDFS 514
+ L L+ LL+ + ++ + + Q A + F NVHF Y +V S
Sbjct: 436 RQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFEYIEGQKV--LSGIS 493
Query: 515 LSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVS 574
+P+G A+VG SGSGKST++ LL R Y+P G+I L G +I+ ++ LR +G V
Sbjct: 494 FEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVP 553
Query: 575 QEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLL 634
Q+ +LF +I N+ YG S + EE+ VA++A I P G++T VGE+G+ L
Sbjct: 554 QDAVLFHNTIYYNLLYGN---ISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKL 610
Query: 635 SGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLST 694
SGG+KQR+AIARA+LK+P ++L DEATS+LD+ E + A+ ++ RT + IAHRLST
Sbjct: 611 SGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHRLST 670
Query: 695 IKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQS 734
+ +A+ + VLDQGK+ E G H LL+ P+ IY ++ + QS
Sbjct: 671 VVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQS 710
>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
[Homo sapiens]
Length = 1545
Score = 182 bits (461), Expect = 1e-45
Identities = 151/496 (30%), Positives = 242/496 (48%), Gaps = 34/496 (6%)
Query: 245 NRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGI 304
N L L ++ILR + FFD T TG ++NR + D + +V + L LR+ +GI
Sbjct: 1054 NILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDIS----TVDDTLPQSLRSWITCFLGI 1109
Query: 305 -SMMFFVSPNLATFVLSVVP------PVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEER 357
S + + F + V+P V + V R LR+L VT+ + E
Sbjct: 1110 ISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFS---ET 1166
Query: 358 IGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIV-----LS 412
+ + +RAF + ++ ++D + + L GNL V +
Sbjct: 1167 VSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFFSALMM 1226
Query: 413 VLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLERE 472
V+Y+ L + TVG + L A + ++ L SE+ + A R+ E + E
Sbjct: 1227 VIYRDTL----SGDTVGFV---LSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVE 1279
Query: 473 PKLPF-NEGVILNEKSFQGALEFKNVHFAYPARPEVP-IFQDFSLSIPSGSVTALVGPSG 530
+ P+ + + +G ++F N Y RPE+ + + + I S +VG +G
Sbjct: 1280 NEAPWVTDKRPPPDWPSKGKIQFNNYQVRY--RPELDLVLRGITCDIGSMEKIGVVGRTG 1337
Query: 531 SGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAY 590
+GKS++ + L R+ + A G I +DG DI + LR K+ + Q+PILFS S+ N+
Sbjct: 1338 AGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNL-- 1395
Query: 591 GADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLK 650
D ++ + EEI + E+A+ +F+ + G + V E G LS GQ+Q + + RALL+
Sbjct: 1396 --DPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLR 1453
Query: 651 NPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKIT 710
KIL+LDEAT+A+D E + L+Q + TV+ IAHRL TI +++ V VLD GKI
Sbjct: 1454 KSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKII 1513
Query: 711 EYGKHEELLSKPNGIY 726
E G EELL P Y
Sbjct: 1514 ECGSPEELLQIPGPFY 1529
Score = 112 bits (281), Expect = 9e-25
Identities = 129/543 (23%), Positives = 242/543 (44%), Gaps = 55/543 (10%)
Query: 208 SDNLTRLCLGLSAVFLCGAAANAIRVYLMQTSGQ---RIVNRLRTSLFSSILRQEVAFFD 264
SD T L +G L AA I+ + +Q Q ++ ++RT++ +S+ ++ + +
Sbjct: 351 SDRDTYLWIGYLCAILLFTAA-LIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSN 409
Query: 265 KTR----TGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLS 320
R GE +N +S D L VT + + Q + I FF+ L VL+
Sbjct: 410 LARKEYTVGETVNLMSVDAQKL-MDVTNFMHMLWSSVLQIVLSI---FFLWRELGPSVLA 465
Query: 321 VVPPVSIIAVIYGRYLRKLTKVTQ----DSLAQATQLAEERIGNVRTVRAFGKEMTEIEK 376
V V ++ + L +K Q + + ++ E + ++ ++ F E
Sbjct: 466 GVG-VMVLVIPINAILSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWE------ 518
Query: 377 YASKVDHVMQLARKE-----AFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGEL 431
S D V L +KE AF++ +++SV+ ++ ++ +
Sbjct: 519 -PSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQ 577
Query: 432 SSFLMYAFW--VGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQ 489
+F + + + L S +++ + RL + L + + I ++ +F
Sbjct: 578 KAFTSITLFNILRFPLSMLPMMISSMLQASVSTERLEKYLGGDD---LDTSAIRHDCNFD 634
Query: 490 GALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASG 549
A++F F + E + +D +L I +G + A++GP GSGKS+++S +L + G
Sbjct: 635 KAMQFSEASFTWEHDSEATV-RDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHG 693
Query: 550 TISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEV 609
I++ G W+++ GT+ +NI +G + + Q+V E
Sbjct: 694 HITIKGTTAYVPQQSWIQN--GTIK-----------DNILFGTE----FNEKRYQQVLEA 736
Query: 610 ANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAE-N 668
+ + P G +GEKG+ LSGGQKQRI++ARA +N I LLD+ SA+DA
Sbjct: 737 CALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVG 796
Query: 669 EYLVQEAL--DRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIY 726
+++ + L + L+ G+T L++ H + + + + VL G I E G + LL+K
Sbjct: 797 KHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFA 856
Query: 727 RKL 729
+ L
Sbjct: 857 KNL 859
>gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3
[Homo sapiens]
Length = 1475
Score = 177 bits (449), Expect = 3e-44
Identities = 144/488 (29%), Positives = 237/488 (48%), Gaps = 21/488 (4%)
Query: 247 LRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASV-GIS 305
L L SILR ++FF++T +G L+NR S + + + E + + G+ +V G
Sbjct: 992 LHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIK--MFMGSLFNVIGAC 1049
Query: 306 MMFFVSPNLATFVLSVVPPVSIIAVIYGRYL----RKLTKVTQDSLAQATQLAEERIGNV 361
++ ++ +A + +PP+ +I R+ R+L ++ S + E + V
Sbjct: 1050 IVILLATPIAAII---IPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGV 1106
Query: 362 RTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLM 421
+RAF ++ I + KVD + A GN IVL + +
Sbjct: 1107 SVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVL---FAALFAV 1163
Query: 422 GSAH-MTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEG 480
S H ++ G + + Y+ V + L SE+ + A RL E E E + P+
Sbjct: 1164 ISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQ 1223
Query: 481 VILNEKSFQ--GALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLS 538
S+ G +EF+N Y + + + +++I G +VG +G+GKS++
Sbjct: 1224 ETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTL 1282
Query: 539 LLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSV 598
L R+ + A G I +DG +I ++ LR KI + Q+P+LFS S+ N+ D S
Sbjct: 1283 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNL----DPFSQY 1338
Query: 599 TAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLD 658
+ EE+ E+A+ F+ P + E G LS GQ+Q + +ARALL+ KIL+LD
Sbjct: 1339 SDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLD 1398
Query: 659 EATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEEL 718
EAT+A+D E + L+Q + + TVL IAHRL+TI + V VLD+G+I EYG +L
Sbjct: 1399 EATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDL 1458
Query: 719 LSKPNGIY 726
L + Y
Sbjct: 1459 LQQRGLFY 1466
Score = 59.7 bits (143), Expect = 9e-09
Identities = 93/493 (18%), Positives = 188/493 (38%), Gaps = 101/493 (20%)
Query: 246 RLRTSLFSSILRQEVAFFDKTR----TGELINRLSSDTALLGRSVTENLSDGLRAGAQAS 301
R++T++ ++ R+ + + R GE++N +S D + ++ A Q
Sbjct: 394 RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRF-MDLATYINMIWSAPLQVI 452
Query: 302 VGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQ----DSLAQATQLAEER 357
+ + +++ NL VL+ V V ++ V + TK Q S +L E
Sbjct: 453 LALYLLWL---NLGPSVLAGVA-VMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEI 508
Query: 358 IGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKG 417
+ ++ ++ + E+ +K + +++ +K A+ A G + +
Sbjct: 509 LNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSA--------VGTFTWVCTPFLV 560
Query: 418 GLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSF--------YSELMKGLGAGGRLWELL 469
L + ++T+ E + +V +++ + F S +++ + RL L
Sbjct: 561 ALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFL 620
Query: 470 EREPKLPFN-EGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGP 528
E P + E + + ++ +N F + AR + P + SIP G++ A+VG
Sbjct: 621 SHEELEPDSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQ 679
Query: 529 SGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENI 588
G GKS++LS LL D G +++ G + V Q+ + + S+ ENI
Sbjct: 680 VGCGKSSLLSALLAEMDKVEGHVAIKG-------------SVAYVPQQAWIQNDSLRENI 726
Query: 589 AYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARAL 648
+G IQ A + + + P G T +GEK +L
Sbjct: 727 LFGCQLEEPYYRSVIQACALLPD----LEILPSGDRTEIGEKTRIL-------------- 768
Query: 649 LKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGK 708
+ H +S + +++ V+ GK
Sbjct: 769 ---------------------------------------VTHSMSYLPQVDVIIVMSGGK 789
Query: 709 ITEYGKHEELLSK 721
I+E G ++ELL++
Sbjct: 790 ISEMGSYQELLAR 802
>gi|134142342 ATP-binding cassette, sub-family C, member 1 isoform 4
[Homo sapiens]
Length = 1416
Score = 177 bits (449), Expect = 3e-44
Identities = 144/488 (29%), Positives = 237/488 (48%), Gaps = 21/488 (4%)
Query: 247 LRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASV-GIS 305
L L SILR ++FF++T +G L+NR S + + + E + + G+ +V G
Sbjct: 933 LHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIK--MFMGSLFNVIGAC 990
Query: 306 MMFFVSPNLATFVLSVVPPVSIIAVIYGRYL----RKLTKVTQDSLAQATQLAEERIGNV 361
++ ++ +A + +PP+ +I R+ R+L ++ S + E + V
Sbjct: 991 IVILLATPIAAII---IPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGV 1047
Query: 362 RTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLM 421
+RAF ++ I + KVD + A GN IVL + +
Sbjct: 1048 SVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVL---FAALFAV 1104
Query: 422 GSAH-MTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEG 480
S H ++ G + + Y+ V + L SE+ + A RL E E E + P+
Sbjct: 1105 ISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQ 1164
Query: 481 VILNEKSFQ--GALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLS 538
S+ G +EF+N Y + + + +++I G +VG +G+GKS++
Sbjct: 1165 ETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTL 1223
Query: 539 LLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSV 598
L R+ + A G I +DG +I ++ LR KI + Q+P+LFS S+ N+ D S
Sbjct: 1224 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNL----DPFSQY 1279
Query: 599 TAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLD 658
+ EE+ E+A+ F+ P + E G LS GQ+Q + +ARALL+ KIL+LD
Sbjct: 1280 SDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLD 1339
Query: 659 EATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEEL 718
EAT+A+D E + L+Q + + TVL IAHRL+TI + V VLD+G+I EYG +L
Sbjct: 1340 EATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDL 1399
Query: 719 LSKPNGIY 726
L + Y
Sbjct: 1400 LQQRGLFY 1407
Score = 47.4 bits (111), Expect = 5e-05
Identities = 64/325 (19%), Positives = 136/325 (41%), Gaps = 31/325 (9%)
Query: 246 RLRTSLFSSILRQEVAFFDKTR----TGELINRLSSDTALLGRSVTENLSDGLRAGAQAS 301
R++T++ ++ R+ + + R GE++N +S D + ++ A Q
Sbjct: 394 RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRF-MDLATYINMIWSAPLQVI 452
Query: 302 VGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQ----DSLAQATQLAEER 357
+ + +++ NL VL+ V V ++ V + TK Q S +L E
Sbjct: 453 LALYLLWL---NLGPSVLAGVA-VMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEI 508
Query: 358 IGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKG 417
+ ++ ++ + E+ +K + +++ +K A+ A G + +
Sbjct: 509 LNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSA--------VGTFTWVCTPFLV 560
Query: 418 GLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSF--------YSELMKGLGAGGRLWELL 469
L + ++T+ E + +V +++ + F S +++ + RL L
Sbjct: 561 ALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFL 620
Query: 470 EREPKLPFN-EGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGP 528
E P + E + + ++ +N F + AR + P + SIP G++ A+VG
Sbjct: 621 SHEELEPDSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQ 679
Query: 529 SGSGKSTVLSLLLRLYDPASGTISL 553
G GKS++LS LL D G +++
Sbjct: 680 VGCGKSSLLSALLAEMDKVEGHVAI 704
Score = 33.9 bits (76), Expect = 0.56
Identities = 12/39 (30%), Positives = 27/39 (69%)
Query: 683 RTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSK 721
+T +++ H +S + +++ V+ GKI+E G ++ELL++
Sbjct: 705 KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLAR 743
>gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2
[Homo sapiens]
Length = 1472
Score = 177 bits (449), Expect = 3e-44
Identities = 144/488 (29%), Positives = 237/488 (48%), Gaps = 21/488 (4%)
Query: 247 LRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASV-GIS 305
L L SILR ++FF++T +G L+NR S + + + E + + G+ +V G
Sbjct: 989 LHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIK--MFMGSLFNVIGAC 1046
Query: 306 MMFFVSPNLATFVLSVVPPVSIIAVIYGRYL----RKLTKVTQDSLAQATQLAEERIGNV 361
++ ++ +A + +PP+ +I R+ R+L ++ S + E + V
Sbjct: 1047 IVILLATPIAAII---IPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGV 1103
Query: 362 RTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLM 421
+RAF ++ I + KVD + A GN IVL + +
Sbjct: 1104 SVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVL---FAALFAV 1160
Query: 422 GSAH-MTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEG 480
S H ++ G + + Y+ V + L SE+ + A RL E E E + P+
Sbjct: 1161 ISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQ 1220
Query: 481 VILNEKSFQ--GALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLS 538
S+ G +EF+N Y + + + +++I G +VG +G+GKS++
Sbjct: 1221 ETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTL 1279
Query: 539 LLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSV 598
L R+ + A G I +DG +I ++ LR KI + Q+P+LFS S+ N+ D S
Sbjct: 1280 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNL----DPFSQY 1335
Query: 599 TAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLD 658
+ EE+ E+A+ F+ P + E G LS GQ+Q + +ARALL+ KIL+LD
Sbjct: 1336 SDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLD 1395
Query: 659 EATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEEL 718
EAT+A+D E + L+Q + + TVL IAHRL+TI + V VLD+G+I EYG +L
Sbjct: 1396 EATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDL 1455
Query: 719 LSKPNGIY 726
L + Y
Sbjct: 1456 LQQRGLFY 1463
Score = 68.9 bits (167), Expect = 2e-11
Identities = 35/98 (35%), Positives = 63/98 (64%), Gaps = 3/98 (3%)
Query: 627 VGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAE-NEYLVQEAL--DRLMDGR 683
V KGV LSGGQKQR+++ARA+ N I L D+ SA+DA +++ + + ++ +
Sbjct: 702 VAIKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNK 761
Query: 684 TVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSK 721
T +++ H +S + +++ V+ GKI+E G ++ELL++
Sbjct: 762 TRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLAR 799
>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
[Homo sapiens]
Length = 1531
Score = 177 bits (449), Expect = 3e-44
Identities = 144/488 (29%), Positives = 237/488 (48%), Gaps = 21/488 (4%)
Query: 247 LRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASV-GIS 305
L L SILR ++FF++T +G L+NR S + + + E + + G+ +V G
Sbjct: 1048 LHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIK--MFMGSLFNVIGAC 1105
Query: 306 MMFFVSPNLATFVLSVVPPVSIIAVIYGRYL----RKLTKVTQDSLAQATQLAEERIGNV 361
++ ++ +A + +PP+ +I R+ R+L ++ S + E + V
Sbjct: 1106 IVILLATPIAAII---IPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGV 1162
Query: 362 RTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLM 421
+RAF ++ I + KVD + A GN IVL + +
Sbjct: 1163 SVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVL---FAALFAV 1219
Query: 422 GSAH-MTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEG 480
S H ++ G + + Y+ V + L SE+ + A RL E E E + P+
Sbjct: 1220 ISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQ 1279
Query: 481 VILNEKSFQ--GALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLS 538
S+ G +EF+N Y + + + +++I G +VG +G+GKS++
Sbjct: 1280 ETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTL 1338
Query: 539 LLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSV 598
L R+ + A G I +DG +I ++ LR KI + Q+P+LFS S+ N+ D S
Sbjct: 1339 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNL----DPFSQY 1394
Query: 599 TAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLD 658
+ EE+ E+A+ F+ P + E G LS GQ+Q + +ARALL+ KIL+LD
Sbjct: 1395 SDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLD 1454
Query: 659 EATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEEL 718
EAT+A+D E + L+Q + + TVL IAHRL+TI + V VLD+G+I EYG +L
Sbjct: 1455 EATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDL 1514
Query: 719 LSKPNGIY 726
L + Y
Sbjct: 1515 LQQRGLFY 1522
Score = 119 bits (298), Expect = 1e-26
Identities = 114/496 (22%), Positives = 224/496 (45%), Gaps = 51/496 (10%)
Query: 246 RLRTSLFSSILRQEVAFFDKTR----TGELINRLSSDTALLGRSVTENLSDGLRAGAQAS 301
R++T++ ++ R+ + + R GE++N +S D + ++ A Q
Sbjct: 394 RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRF-MDLATYINMIWSAPLQVI 452
Query: 302 VGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQ----DSLAQATQLAEER 357
+ + +++ NL VL+ V V ++ V + TK Q S +L E
Sbjct: 453 LALYLLWL---NLGPSVLAGVA-VMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEI 508
Query: 358 IGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKG 417
+ ++ ++ + E+ +K + +++ +K A+ A G + +
Sbjct: 509 LNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSA--------VGTFTWVCTPFLV 560
Query: 418 GLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSF--------YSELMKGLGAGGRLWELL 469
L + ++T+ E + +V +++ + F S +++ + RL L
Sbjct: 561 ALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFL 620
Query: 470 EREPKLPFN-EGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGP 528
E P + E + + ++ +N F + AR + P + SIP G++ A+VG
Sbjct: 621 SHEELEPDSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQ 679
Query: 529 SGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENI 588
G GKS++LS LL D G +++ G + V Q+ + + S+ ENI
Sbjct: 680 VGCGKSSLLSALLAEMDKVEGHVAIKG-------------SVAYVPQQAWIQNDSLRENI 726
Query: 589 AYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARAL 648
+G IQ A + + + P G T +GEKGV LSGGQKQR+++ARA+
Sbjct: 727 LFGCQLEEPYYRSVIQACALLPD----LEILPSGDRTEIGEKGVNLSGGQKQRVSLARAV 782
Query: 649 LKNPKILLLDEATSALDAE-NEYLVQEAL--DRLMDGRTVLVIAHRLSTIKNANMVAVLD 705
N I L D+ SA+DA +++ + + ++ +T +++ H +S + +++ V+
Sbjct: 783 YSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMS 842
Query: 706 QGKITEYGKHEELLSK 721
GKI+E G ++ELL++
Sbjct: 843 GGKISEMGSYQELLAR 858
>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
sapiens]
Length = 1464
Score = 172 bits (435), Expect = 1e-42
Identities = 148/516 (28%), Positives = 252/516 (48%), Gaps = 37/516 (7%)
Query: 231 IRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENL 290
+R L + L L +L V FF+ T TG ++NR SSD A S+ L
Sbjct: 956 LRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSDVACADDSLPFIL 1015
Query: 291 SDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLR----KLTKVTQDS 346
+ L A G+ + V + ++L ++PP+SI+ R+ R +L ++ +
Sbjct: 1016 NILLANAA----GLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHYRASSRELRRLGSLT 1071
Query: 347 LAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFA----------RA 396
L+ + + + +RA G ++ + +++L ++ FA R
Sbjct: 1072 LSPLYSHLADTLAGLSVLRATGATY----RFEEENLRLLELNQRCQFATSATMQWLDIRL 1127
Query: 397 GFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELM 456
GA +S + V ++ GL G + L YA + + GL S +++
Sbjct: 1128 QLMGAAVVSAIAGIALVQHQQGLA------NPGLVGLSLSYALSLTGLLSGLVSSFTQTE 1181
Query: 457 KGLGAGGRLWELLEREPKLPFNEGVILNEKSF-QGALEFKNVHFAYPARPEVPIFQD-FS 514
L + RL E P+ P + + L QG +EF++V AY RP +P D +
Sbjct: 1182 AMLVSVERLEEYTCDLPQEPQGQPLQLGTGWLTQGGVEFQDVVLAY--RPGLPNALDGVT 1239
Query: 515 LSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVS 574
+ G +VG +GSGKS++L +L RL +P+SG + LDG D QL LRS++ +
Sbjct: 1240 FCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIP 1299
Query: 575 QEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLL 634
QEP LFS ++ EN+ DP + + A ++ + G + +GE G L
Sbjct: 1300 QEPFLFSGTVRENL-----DPQGLHKDRALWQALKQCHLSEVITSMGGLDGELGEGGRSL 1354
Query: 635 SGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLST 694
S GQ+Q + +ARALL + KIL +DEAT+++D + + L+Q+ + + +TVL IAHRL+T
Sbjct: 1355 SLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRLNT 1414
Query: 695 IKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLM 730
I N++ V VL G++ E L ++P+ ++++L+
Sbjct: 1415 ILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLL 1450
Score = 90.1 bits (222), Expect = 7e-18
Identities = 60/206 (29%), Positives = 104/206 (50%), Gaps = 15/206 (7%)
Query: 515 LSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVS 574
L + G + +VG G GKS++L+ + G +++ G L G +
Sbjct: 593 LEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRG----------LSKGFGLAT 642
Query: 575 QEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLL 634
QEP + +I +NI +G + A+ + V E + P G T VGEKGV L
Sbjct: 643 QEPWIQFATIRDNILFG----KTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTL 698
Query: 635 SGGQKQRIAIARALLKNPKILLLDEATSALDAE-NEYLVQEALDRLMDGRTVLVIAHRLS 693
SGGQ+ RIA+ARA+ + ++ LLD+ +A+DA+ +L+ + ++ T L+ HR
Sbjct: 699 SGGQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTE 758
Query: 694 TIKNANMVAVLDQGKITEYGKHEELL 719
++ A+ V +++ G++ G E+L
Sbjct: 759 YLERADAVLLMEAGRLIRAGPPSEIL 784
>gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo
sapiens]
Length = 1581
Score = 168 bits (425), Expect = 2e-41
Identities = 134/509 (26%), Positives = 250/509 (49%), Gaps = 38/509 (7%)
Query: 236 MQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLR 295
++ +G ++ RL SL + I+ + FF+ T G ++NR SSD + + + L R
Sbjct: 1085 VEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSR 1144
Query: 296 AGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLA- 354
+ ++++ +V+P F+++++P ++I+ +Y R ++ Q L TQL
Sbjct: 1145 STLLCVSALAVISYVTP---VFLVALLP-LAIVCYFIQKYFRVASRDLQQ-LDDTTQLPL 1199
Query: 355 ----EERIGNVRTVRAFGKEMTEIEKYASKVDH------VMQLARKEAFARAGFFGATGL 404
E + + T+RAF E +K D + A + R + GA
Sbjct: 1200 LSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGAC-- 1257
Query: 405 SGNLIVLSVLYKGGLLMGSAH--MTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAG 462
+++++ + + S H ++ G + L YA V + + +++ LGA
Sbjct: 1258 ---VVLIAAVTS---ISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAV 1311
Query: 463 GRLWELLEREPKLPFNEGVI---LNEKSF--QGALEFKNVHFAYPARPEVPIFQDFSLSI 517
R+ LL+ E + EG++ L K++ QG ++ +N+ Y + + P+ + + I
Sbjct: 1312 KRIHGLLKTEAES--YEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLK-PVLKHVNALI 1368
Query: 518 PSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEP 577
G + G +GSGKS+ R+ D G I +DG DI +L LRS++ + Q+P
Sbjct: 1369 APGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDP 1428
Query: 578 ILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGG 637
+LFS +I N+ D + + E+A ++ P G + ++ E G S G
Sbjct: 1429 VLFSGTIRFNL----DPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQG 1484
Query: 638 QKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKN 697
Q+Q +ARA ++ I ++DEAT+++D E ++Q+ + RTV+ IAHR+ TI +
Sbjct: 1485 QRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILS 1544
Query: 698 ANMVAVLDQGKITEYGKHEELLSKPNGIY 726
A++V VL +G I E+ K E+LLS+ + ++
Sbjct: 1545 ADLVIVLKRGAILEFDKPEKLLSRKDSVF 1573
Score = 102 bits (254), Expect = 1e-21
Identities = 72/247 (29%), Positives = 126/247 (51%), Gaps = 25/247 (10%)
Query: 507 VPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTI---SLDGHDIRQLNP 563
+P + ++ IP G +T +VG G GKS++L L SG + SL +I + +P
Sbjct: 693 IPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGE-DP 751
Query: 564 -----------VWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANA 612
+ R + SQ+P L + ++ ENI + S + + V E +
Sbjct: 752 SPERETATDLDIRKRGPVAYASQKPWLLNATVEENIIF----ESPFNKQRYKMVIEACSL 807
Query: 613 VAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAE-NEYL 671
I P G T +GE+G+ LSGGQ+QRI++ARAL ++ ++ LD+ SALD +++L
Sbjct: 808 QPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHL 867
Query: 672 VQEALDRLM--DGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIY--- 726
+Q + L+ D RTV+++ H+L + +A+ + + G I G ++ ++
Sbjct: 868 MQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHW 927
Query: 727 RKLMNKQ 733
+ LMN+Q
Sbjct: 928 KTLMNRQ 934
>gi|89111135 ATP-binding cassette protein C12 [Homo sapiens]
Length = 1359
Score = 167 bits (424), Expect = 2e-41
Identities = 141/492 (28%), Positives = 233/492 (47%), Gaps = 30/492 (6%)
Query: 247 LRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISM 306
L ++F IL+ ++FFD T TG L+NR S D L + + + L+ + +
Sbjct: 884 LHDTVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILVI 943
Query: 307 MFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRA 366
+ V P + V S+ I+ I+ R +++L KV S + + + + A
Sbjct: 944 LAAVFPAVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGLGIIHA 1003
Query: 367 FGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHM 426
+GK+ + I + + ++ FA L ++++ + + LL+ +
Sbjct: 1004 YGKKESCITYHLLYFNCALRW-----FA---------LRMDVLMNILTFTVALLVTLSFS 1049
Query: 427 TVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLER-------EPKLPFNE 479
++ S L ++ + +S GL A ELL E P
Sbjct: 1050 SISTSSKGLSLSYIIQLS--GLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLKV 1107
Query: 480 GVILNEKSFQGALEFKNVHFAYPARPEVPIFQD-FSLSIPSGSVTALVGPSGSGKSTVLS 538
G + +G + F++ Y R P+ D +L+I SG +VG +GSGKS++
Sbjct: 1108 GTCPKDWPSRGEITFRDYQMRY--RDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGM 1165
Query: 539 LLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSV 598
L RL +PASGTI +D DI L+ LR+K+ + Q+P+LF + Y D S
Sbjct: 1166 ALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLF----VGTVRYNLDPFESH 1221
Query: 599 TAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLD 658
T E + +V E I P+ V E G S G++Q + +ARALL+N KI+LLD
Sbjct: 1222 TDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLD 1281
Query: 659 EATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEEL 718
EAT+++D++ + LVQ + G TVL IAHRL+T+ N + V V++ GK+ E+ K E L
Sbjct: 1282 EATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVL 1341
Query: 719 LSKPNGIYRKLM 730
KP+ + L+
Sbjct: 1342 AEKPDSAFAMLL 1353
Score = 114 bits (285), Expect = 3e-25
Identities = 67/224 (29%), Positives = 122/224 (54%), Gaps = 19/224 (8%)
Query: 509 IFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRS 568
+ S + G + + G GSGKS++L+ LL G ++++G
Sbjct: 495 VLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNG------------- 541
Query: 569 KIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVG 628
+ VSQ+ +F ++ ENI +G + Q V + N P G T +G
Sbjct: 542 TLAYVSQQAWIFHGNVRENILFG----EKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIG 597
Query: 629 EKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAE-NEYLVQEALDRLMDGRTVLV 687
E+G+ LSGGQ+QRI++ARA+ + ++ LLD+ SA+DA +++ +E + + + G+TV++
Sbjct: 598 ERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVL 657
Query: 688 IAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMN 731
+ H+L +++ + V +L+ G+I E G H+EL+ + G Y KL++
Sbjct: 658 VTHQLQFLESCDEVILLEDGEICEKGTHKELMEE-RGRYAKLIH 700
>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
[Homo sapiens]
Length = 1527
Score = 167 bits (423), Expect = 3e-41
Identities = 148/564 (26%), Positives = 260/564 (46%), Gaps = 29/564 (5%)
Query: 172 AAAVGFLTMSSV----ISMSAPFFLGKIIDVIYTNPTV-DYSDNLTRLCLGLSAV----- 221
A AVG T ++ + SA + +TN + D N T L LG+ A
Sbjct: 963 AKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQ 1022
Query: 222 -FLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTA 280
FL AA A M G + L +L + +R +FFD T +G ++N S D
Sbjct: 1023 GFLVMLAAMA-----MAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIY 1077
Query: 281 LLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLT 340
++ + + L + A + ++ +P +L + +++ Y R+L
Sbjct: 1078 VVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLK 1137
Query: 341 KVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFG 400
++ S + E + +RA+ + +KVD + +
Sbjct: 1138 RLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSI 1197
Query: 401 ATGLSGNLIVL-SVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGL 459
GN +VL + L+ ++G + + G + + Y+ V ++ + S+L +
Sbjct: 1198 GVEFVGNCVVLFAALFA---VIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNI 1254
Query: 460 GAGGRLWELLEREPKLPFNEGVILNEKSF--QGALEFKNVHFAYPARPEVP-IFQDFSLS 516
A R+ E + E + P+ + + +G +EF+N Y RP + + +D SL
Sbjct: 1255 VAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRY--RPGLDLVLRDLSLH 1312
Query: 517 IPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQE 576
+ G +VG +G+GKS++ L R+ + A G I +DG ++ + LRS++ + Q+
Sbjct: 1313 VHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQD 1372
Query: 577 PILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSG 636
PILFS ++ N+ D S + E+I E+++ F+ + P G + E G LS
Sbjct: 1373 PILFSGTLRMNL----DPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSV 1428
Query: 637 GQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIK 696
GQ+Q + +ARALL+ +IL+LDEAT+A+D E + L+Q + D TVL IAHRL+TI
Sbjct: 1429 GQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIM 1488
Query: 697 NANMVAVLDQGKITEYGKHEELLS 720
+ V VLD+G + E+ L++
Sbjct: 1489 DYTRVLVLDKGVVAEFDSPANLIA 1512
Score = 111 bits (277), Expect = 3e-24
Identities = 142/627 (22%), Positives = 269/627 (42%), Gaps = 62/627 (9%)
Query: 131 EAWRRGPAAPPGDKGRLRPAAAGLPEARKLLGLAYPERRR------LAAAVG-------- 176
EAWR+ K P E LLG A P R+ L A G
Sbjct: 258 EAWRKQEKQTARHKASAAPGKNASGEDEVLLG-ARPRPRKPSFLKALLATFGSSFLISAC 316
Query: 177 FLTMSSVISMSAPFFLGKIIDVIYTNPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLM 236
F + ++S P L +I I +NP L GL +FLC + I +
Sbjct: 317 FKLIQDLLSFINPQLLSILIRFI-SNPMAPSWWGF--LVAGL--MFLCSMMQSLILQHYY 371
Query: 237 QTSGQRIVNRLRTSLFSSILRQEVAFFDKTR----TGELINRLSSDTALLGRSVTENLSD 292
V + RT + I R+ + + + GE++N +S D +L+
Sbjct: 372 HYIFVTGV-KFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRF-----MDLAP 425
Query: 293 GLRAGAQASVGISM-MFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLT--KVTQDSLAQ 349
L A + I + ++F+ NL VL+ V + ++ + G K+ +V Q L
Sbjct: 426 FLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKD 485
Query: 350 AT-QLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNL 408
+ +L E + ++ ++ + E + +++ +QL R A+ S L
Sbjct: 486 SRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFL 545
Query: 409 IVLSVLYKGGLLMGSAHMTVGELSSFLMYAFW--VGISIGGLSSFYSELMKGLGAGGRLW 466
+ L L+ + + + +F+ + + + + + L S L + + R+
Sbjct: 546 VTLITLWV--YVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQ 603
Query: 467 ELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALV 526
+ L +E P + V S A+ + F + A+ P + +P G++ A+V
Sbjct: 604 QFLSQEELDP--QSVERKTISPGYAITIHSGTFTW-AQDLPPTLHSLDIQVPKGALVAVV 660
Query: 527 GPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAE 586
GP G GKS+++S LL + G + + G + V Q+ + +C++ E
Sbjct: 661 GPVGCGKSSLVSALLGEMEKLEGKVHMKG-------------SVAYVPQQAWIQNCTLQE 707
Query: 587 NIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIAR 646
N+ +G ++ + Q+ E +A + P G T +GEKG+ LSGGQ+QR+++AR
Sbjct: 708 NVLFG----KALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLAR 763
Query: 647 ALLKNPKILLLDEATSALDAE-NEYLVQEAL--DRLMDGRTVLVIAHRLSTIKNANMVAV 703
A+ + I LLD+ SA+D+ +++ + + ++ G+T +++ H +S + + + V
Sbjct: 764 AVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIV 823
Query: 704 LDQGKITEYGKHEELLSKPNGIYRKLM 730
L G+++E G + LL + NG + +
Sbjct: 824 LADGQVSEMGPYPALLQR-NGSFANFL 849
>gi|110832837 ATP-binding cassette, sub-family C, member 9 isoform
SUR2B [Homo sapiens]
Length = 1549
Score = 166 bits (419), Expect = 9e-41
Identities = 140/531 (26%), Positives = 243/531 (45%), Gaps = 58/531 (10%)
Query: 223 LCGAAANAIRV--YLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTA 280
LCGA V ++ G L +L + I+ + FFD T G ++NR S+DT
Sbjct: 1042 LCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTN 1101
Query: 281 LLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLT 340
++ + + L R+ I M+ + +P F+++++P + + +Y R +
Sbjct: 1102 IIDQHIPPTLESLTRSTLLCLSAIGMISYATP---VFLVALLP-LGVAFYFIQKYFRVAS 1157
Query: 341 KVTQDSLAQATQLA-----EERIGNVRTVRAFGKE------MTEIEKYASKVDHVMQLAR 389
K Q+ L +TQL E + T+RAF E M E+ + + A
Sbjct: 1158 KDLQE-LDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAAN 1216
Query: 390 KEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLS 449
+ R + GA IVL+ + GS++ G + L+YA + + +
Sbjct: 1217 RWLEVRTDYLGAC------IVLTASIAS--ISGSSNS--GLVGLGLLYALTITNYLNWVV 1266
Query: 450 SFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEV-- 507
++L +GA ++ N + + ++++G ++ V +P E+
Sbjct: 1267 RNLADLEVQMGAVKKV------------NSFLTMESENYEGTMDPSQVPEHWPQEGEIKI 1314
Query: 508 ------------PIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDG 555
P+ + I G + G +GSGKS++ R+ D G I +DG
Sbjct: 1315 HDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDG 1374
Query: 556 HDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAF 615
DI +L LRS++ + Q+PILFS SI N+ D T + + E+A
Sbjct: 1375 IDISKLPLHTLRSRLSIILQDPILFSGSIRFNL----DPECKCTDDRLWEALEIAQLKNM 1430
Query: 616 IRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEA 675
+++ P G + VV E G S GQ+Q +ARA ++ IL++DEAT+++D E ++Q+
Sbjct: 1431 VKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKV 1490
Query: 676 LDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIY 726
+ RTV+ IAHR+ TI A++V V+ +G I EY E LL++ NG++
Sbjct: 1491 VMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQENGVF 1541
Score = 107 bits (268), Expect = 3e-23
Identities = 71/253 (28%), Positives = 135/253 (53%), Gaps = 16/253 (6%)
Query: 491 ALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGT 550
A++ N +F++ + + + + IP+G +T +VG G GKS++L +L G
Sbjct: 671 AIKVTNGYFSWGSG--LATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGK 728
Query: 551 ISLDGHDIRQLNPVWLRSK----IGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRV 606
+ + + + RS+ + +Q+P L + ++ ENI +G S + + V
Sbjct: 729 VHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFG----SPFNKQRYKAV 784
Query: 607 AEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDA 666
+ + I P G T +GE+G+ LSGGQ+QRI +ARAL +N I+ LD+ SALD
Sbjct: 785 TDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDI 844
Query: 667 E-NEYLVQEALDRLM--DGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPN 723
+++L+QE + + + D RT++++ H+L + +A+ + + G + G +++ +K
Sbjct: 845 HLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDV 904
Query: 724 GIY---RKLMNKQ 733
+Y + LMN+Q
Sbjct: 905 ELYEHWKTLMNRQ 917
>gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1
[Homo sapiens]
Length = 1503
Score = 164 bits (414), Expect = 4e-40
Identities = 141/500 (28%), Positives = 242/500 (48%), Gaps = 29/500 (5%)
Query: 240 GQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQ 299
G R L L ++R ++FF++T G L+NR S +T +V ++ D LR+
Sbjct: 1013 GARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETD----TVDVDIPDKLRSLLM 1068
Query: 300 ASVG---ISMMFFVSPNLATFVLSVVPPVSIIAVIYGRY------LRKLTKVTQDSLAQA 350
+ G +S++ V+ LAT ++++P + A Y LR+L + S+
Sbjct: 1069 YAFGLLEVSLVVAVATPLAT--VAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVC-- 1124
Query: 351 TQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIV 410
+ +AE G+ VRAF + + + ++VD +++ A L GN +V
Sbjct: 1125 SHMAETFQGST-VVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLV 1183
Query: 411 LSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLE 470
+ ++ AH++ G + + A V ++ + +++L + + R+ +
Sbjct: 1184 FAAATCA--VLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAW 1241
Query: 471 REPKLPFNEGVILNEKSFQ--GALEFKNVHFAYPARPEVPI-FQDFSLSIPSGSVTALVG 527
+ P+ + + G +EF++ Y RPE+P+ Q S I +G +VG
Sbjct: 1242 TPKEAPWRLPTCAAQPPWPQGGQIEFRDFGLRY--RPELPLAVQGVSFKIHAGEKVGIVG 1299
Query: 528 PSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAEN 587
+G+GKS++ S LLRL + A G I +DG I + LRS+I + Q+PILF S+ N
Sbjct: 1300 RTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMN 1359
Query: 588 IAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARA 647
+ D + E I E A + + P ++G LS GQKQ + +ARA
Sbjct: 1360 L----DLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARA 1415
Query: 648 LLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQG 707
LL+ +IL+LDEAT+A+D E +Q L TVL+IAHRL ++ + V V+D+G
Sbjct: 1416 LLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKG 1475
Query: 708 KITEYGKHEELLSKPNGIYR 727
++ E G +LL++ YR
Sbjct: 1476 QVAESGSPAQLLAQKGLFYR 1495
Score = 120 bits (300), Expect = 6e-27
Identities = 71/222 (31%), Positives = 122/222 (54%), Gaps = 22/222 (9%)
Query: 508 PIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLR 567
P +L++P G + A+VGP G+GKS++LS LL G +S++G
Sbjct: 644 PCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEG------------ 691
Query: 568 SKIGTVSQEPILFSCSIAENIAYGAD-DPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTV 626
+ V QE + + S+ EN+ +G + DP ++RV E + +FP+G +T
Sbjct: 692 -AVAYVPQEAWVQNTSVVENVCFGQELDPPW-----LERVLEACALQPDVDSFPEGIHTS 745
Query: 627 VGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAE-NEYLVQEAL--DRLMDGR 683
+GE+G+ LSGGQKQR+++ARA+ + + LLD+ +ALDA +++ + + L+ G
Sbjct: 746 IGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGT 805
Query: 684 TVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGI 725
T +++ H L + A+ + VL G I E G ++ELL + +
Sbjct: 806 TRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGAL 847
>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1312
Score = 163 bits (413), Expect = 5e-40
Identities = 141/500 (28%), Positives = 242/500 (48%), Gaps = 29/500 (5%)
Query: 240 GQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQ 299
G R L L ++R ++FF++T G L+NR S +T +V ++ D LR+
Sbjct: 822 GARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETD----TVDVDIPDKLRSLLM 877
Query: 300 ASVG---ISMMFFVSPNLATFVLSVVPPVSIIAVIYGRY------LRKLTKVTQDSLAQA 350
+ G +S++ V+ LAT ++++P + A Y LR+L + S+
Sbjct: 878 YAFGLLEVSLVVAVATPLAT--VAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVC-- 933
Query: 351 TQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIV 410
+ +AE G+ VRAF + + + ++VD +++ A L GN +V
Sbjct: 934 SHMAETFQGST-VVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLV 992
Query: 411 LSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLE 470
+ ++ AH++ G + + A V ++ + +++L + + R+ +
Sbjct: 993 FAAATCA--VLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAW 1050
Query: 471 REPKLPFNEGVILNEKSFQ--GALEFKNVHFAYPARPEVPI-FQDFSLSIPSGSVTALVG 527
+ P+ + + G +EF++ Y RPE+P+ Q S I +G +VG
Sbjct: 1051 TPKEAPWRLPTCAAQPPWPQGGQIEFQDFGLRY--RPELPLAVQGVSFKIHAGEKVGIVG 1108
Query: 528 PSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAEN 587
+G+GKS++ S LLRL + A G I +DG I + LRS+I + Q+PILF S+ N
Sbjct: 1109 RTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMN 1168
Query: 588 IAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARA 647
+ D + E I E A + + P ++G LS GQKQ + +ARA
Sbjct: 1169 L----DLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARA 1224
Query: 648 LLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQG 707
LL+ +IL+LDEAT+A+D E +Q L TVL+IAHRL ++ + V V+D+G
Sbjct: 1225 LLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKG 1284
Query: 708 KITEYGKHEELLSKPNGIYR 727
++ E G +LL++ YR
Sbjct: 1285 QVAESGSPAQLLAQKGLFYR 1304
Score = 120 bits (300), Expect = 6e-27
Identities = 71/222 (31%), Positives = 122/222 (54%), Gaps = 22/222 (9%)
Query: 508 PIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLR 567
P +L++P G + A+VGP G+GKS++LS LL G +S++G
Sbjct: 453 PCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEG------------ 500
Query: 568 SKIGTVSQEPILFSCSIAENIAYGAD-DPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTV 626
+ V QE + + S+ EN+ +G + DP ++RV E + +FP+G +T
Sbjct: 501 -AVAYVPQEAWVQNTSVVENVCFGQELDPPW-----LERVLEACALQPDVDSFPEGIHTS 554
Query: 627 VGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAE-NEYLVQEAL--DRLMDGR 683
+GE+G+ LSGGQKQR+++ARA+ + + LLD+ +ALDA +++ + + L+ G
Sbjct: 555 IGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGT 614
Query: 684 TVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGI 725
T +++ H L + A+ + VL G I E G ++ELL + +
Sbjct: 615 TRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGAL 656
>gi|110832839 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A-delta-14 [Homo sapiens]
Length = 1513
Score = 159 bits (401), Expect = 1e-38
Identities = 138/535 (25%), Positives = 242/535 (45%), Gaps = 58/535 (10%)
Query: 223 LCGAAANAIRV--YLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTA 280
LCGA V ++ G L +L + I+ + FFD T G ++NR S+DT
Sbjct: 1006 LCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTN 1065
Query: 281 LLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLT 340
++ + + L R+ I M+ + +P F+++++P + + +Y R +
Sbjct: 1066 IIDQHIPPTLESLTRSTLLCLSAIGMISYATP---VFLVALLP-LGVAFYFIQKYFRVAS 1121
Query: 341 KVTQDSLAQATQLA-----EERIGNVRTVRAFGKE------MTEIEKYASKVDHVMQLAR 389
K Q+ L +TQL E + T+RAF E M E+ + + A
Sbjct: 1122 KDLQE-LDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAAN 1180
Query: 390 KEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLS 449
+ R + GA IVL+ + GS++ G + L+YA + + +
Sbjct: 1181 RWLEVRTDYLGAC------IVLTASIAS--ISGSSNS--GLVGLGLLYALTITNYLNWVV 1230
Query: 450 SFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEV-- 507
++L +GA ++ N + + ++++G ++ V +P E+
Sbjct: 1231 RNLADLEVQMGAVKKV------------NSFLTMESENYEGTMDPSQVPEHWPQEGEIKI 1278
Query: 508 ------------PIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDG 555
P+ + I G + G +GSGKS++ R+ D G I +DG
Sbjct: 1279 HDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDG 1338
Query: 556 HDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAF 615
DI +L LRS++ + Q+PILFS SI N+ D T + + E+A
Sbjct: 1339 IDISKLPLHTLRSRLSIILQDPILFSGSIRFNL----DPECKCTDDRLWEALEIAQLKNM 1394
Query: 616 IRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEA 675
+++ P G + VV E G S GQ+Q +ARA ++ IL++DEAT+++D E ++Q+
Sbjct: 1395 VKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKV 1454
Query: 676 LDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLM 730
+ RTV+ IAHR+S+I +A +V V +G + E LL+ NG++ L+
Sbjct: 1455 VMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLV 1509
Score = 107 bits (266), Expect = 5e-23
Identities = 68/232 (29%), Positives = 125/232 (53%), Gaps = 14/232 (6%)
Query: 512 DFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSK-- 569
+ + IP+G +T +VG G GKS++L +L G + + + + RS+
Sbjct: 654 NIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNR 713
Query: 570 --IGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVV 627
+ +Q+P L + ++ ENI +G S + + V + + I P G T +
Sbjct: 714 YSVAYAAQKPWLLNATVEENITFG----SPFNKQRYKAVTDACSLQPDIDLLPFGDQTEI 769
Query: 628 GEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAE-NEYLVQEALDRLM--DGRT 684
GE+G+ LSGGQ+QRI +ARAL +N I+ LD+ SALD +++L+QE + + + D RT
Sbjct: 770 GERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRT 829
Query: 685 VLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIY---RKLMNKQ 733
++++ H+L + +A+ + + G + G +++ +K +Y + LMN+Q
Sbjct: 830 LVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQ 881
>gi|110832835 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A [Homo sapiens]
Length = 1549
Score = 159 bits (401), Expect = 1e-38
Identities = 138/535 (25%), Positives = 242/535 (45%), Gaps = 58/535 (10%)
Query: 223 LCGAAANAIRV--YLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTA 280
LCGA V ++ G L +L + I+ + FFD T G ++NR S+DT
Sbjct: 1042 LCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTN 1101
Query: 281 LLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLT 340
++ + + L R+ I M+ + +P F+++++P + + +Y R +
Sbjct: 1102 IIDQHIPPTLESLTRSTLLCLSAIGMISYATP---VFLVALLP-LGVAFYFIQKYFRVAS 1157
Query: 341 KVTQDSLAQATQLA-----EERIGNVRTVRAFGKE------MTEIEKYASKVDHVMQLAR 389
K Q+ L +TQL E + T+RAF E M E+ + + A
Sbjct: 1158 KDLQE-LDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAAN 1216
Query: 390 KEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLS 449
+ R + GA IVL+ + GS++ G + L+YA + + +
Sbjct: 1217 RWLEVRTDYLGAC------IVLTASIAS--ISGSSNS--GLVGLGLLYALTITNYLNWVV 1266
Query: 450 SFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEV-- 507
++L +GA ++ N + + ++++G ++ V +P E+
Sbjct: 1267 RNLADLEVQMGAVKKV------------NSFLTMESENYEGTMDPSQVPEHWPQEGEIKI 1314
Query: 508 ------------PIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDG 555
P+ + I G + G +GSGKS++ R+ D G I +DG
Sbjct: 1315 HDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDG 1374
Query: 556 HDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAF 615
DI +L LRS++ + Q+PILFS SI N+ D T + + E+A
Sbjct: 1375 IDISKLPLHTLRSRLSIILQDPILFSGSIRFNL----DPECKCTDDRLWEALEIAQLKNM 1430
Query: 616 IRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEA 675
+++ P G + VV E G S GQ+Q +ARA ++ IL++DEAT+++D E ++Q+
Sbjct: 1431 VKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKV 1490
Query: 676 LDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLM 730
+ RTV+ IAHR+S+I +A +V V +G + E LL+ NG++ L+
Sbjct: 1491 VMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLV 1545
Score = 107 bits (268), Expect = 3e-23
Identities = 71/253 (28%), Positives = 135/253 (53%), Gaps = 16/253 (6%)
Query: 491 ALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGT 550
A++ N +F++ + + + + IP+G +T +VG G GKS++L +L G
Sbjct: 671 AIKVTNGYFSWGSG--LATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGK 728
Query: 551 ISLDGHDIRQLNPVWLRSK----IGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRV 606
+ + + + RS+ + +Q+P L + ++ ENI +G S + + V
Sbjct: 729 VHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFG----SPFNKQRYKAV 784
Query: 607 AEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDA 666
+ + I P G T +GE+G+ LSGGQ+QRI +ARAL +N I+ LD+ SALD
Sbjct: 785 TDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDI 844
Query: 667 E-NEYLVQEALDRLM--DGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPN 723
+++L+QE + + + D RT++++ H+L + +A+ + + G + G +++ +K
Sbjct: 845 HLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDV 904
Query: 724 GIY---RKLMNKQ 733
+Y + LMN+Q
Sbjct: 905 ELYEHWKTLMNRQ 917
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,549,940
Number of Sequences: 37866
Number of extensions: 1454367
Number of successful extensions: 7074
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 99
Number of HSP's successfully gapped in prelim test: 280
Number of HSP's that attempted gapping in prelim test: 5621
Number of HSP's gapped (non-prelim): 1384
length of query: 738
length of database: 18,247,518
effective HSP length: 110
effective length of query: 628
effective length of database: 14,082,258
effective search space: 8843658024
effective search space used: 8843658024
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.