Guide to the Human Genome
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Search of human proteins with 112382233

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|112382233 mucin 4 isoform d [Homo sapiens]
         (1176 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|112382233 mucin 4 isoform d [Homo sapiens]                        2485   0.0  
gi|167736355 mucin 4 isoform a [Homo sapiens]                        2427   0.0  
gi|112382231 mucin 4 isoform e [Homo sapiens]                        2361   0.0  
gi|10092665 sushi domain containing 2 [Homo sapiens]                  140   5e-33
gi|115298674 nidogen 1 precursor [Homo sapiens]                        71   5e-12
gi|144953895 nidogen 2 precursor [Homo sapiens]                        69   3e-11
gi|134268640 tectorin alpha precursor [Homo sapiens]                   59   3e-08
gi|122937283 6720455I24Rik homolog [Homo sapiens]                      58   6e-08
gi|24041035 notch 2 preproprotein [Homo sapiens]                       55   3e-07
gi|55770876 notch4 preproprotein [Homo sapiens]                        54   1e-06
gi|9506545 delta-like 4 protein precursor [Homo sapiens]               53   1e-06
gi|154146262 Fc fragment of IgG binding protein [Homo sapiens]         53   2e-06
gi|126091152 cubilin [Homo sapiens]                                    52   3e-06
gi|61743978 stabilin 1 precursor [Homo sapiens]                        51   6e-06
gi|239751787 PREDICTED: hypothetical protein XP_002348012 [Homo ...    50   1e-05
gi|11321571 slit homolog 3 [Homo sapiens]                              50   2e-05
gi|134031945 SCO-spondin [Homo sapiens]                                50   2e-05
gi|110735443 delta-like 1 [Homo sapiens]                               48   6e-05
gi|148833508 notch1 preproprotein [Homo sapiens]                       46   2e-04
gi|126012562 low density lipoprotein-related protein 1 [Homo sap...    46   2e-04
gi|153945878 mucin 5, subtype B, tracheobronchial [Homo sapiens]       46   2e-04
gi|4557679 jagged 1 precursor [Homo sapiens]                           46   2e-04
gi|21704279 jagged 2 isoform b precursor [Homo sapiens]                46   2e-04
gi|21704277 jagged 2 isoform a precursor [Homo sapiens]                46   2e-04
gi|209571519 cysteine rich BMP regulator 2 isoform 1 [Homo sapiens]    46   2e-04
gi|161019170 mucin 5AC [Homo sapiens]                                  45   3e-04
gi|239757286 PREDICTED: similar to Fc fragment of IgG binding pr...    45   3e-04
gi|62988324 tenascin N [Homo sapiens]                                  45   4e-04
gi|89191868 von Willebrand factor preproprotein [Homo sapiens]         45   5e-04
gi|239757284 PREDICTED: similar to Fc fragment of IgG binding pr...    45   5e-04

>gi|112382233 mucin 4 isoform d [Homo sapiens]
          Length = 1176

 Score = 2485 bits (6441), Expect = 0.0
 Identities = 1176/1176 (100%), Positives = 1176/1176 (100%)

Query: 1    MKGARWRRVPWVSLSCLCLCLLPHVVPGMTTPSLKTDGGRRTATSPPPTTSQTIISTIPS 60
            MKGARWRRVPWVSLSCLCLCLLPHVVPGMTTPSLKTDGGRRTATSPPPTTSQTIISTIPS
Sbjct: 1    MKGARWRRVPWVSLSCLCLCLLPHVVPGMTTPSLKTDGGRRTATSPPPTTSQTIISTIPS 60

Query: 61   TAMHTRSTAAPIPILPERGVSLFPYGAGAGDLEFVRRTVDFTSPLFKPATGFPLGSSLRD 120
            TAMHTRSTAAPIPILPERGVSLFPYGAGAGDLEFVRRTVDFTSPLFKPATGFPLGSSLRD
Sbjct: 61   TAMHTRSTAAPIPILPERGVSLFPYGAGAGDLEFVRRTVDFTSPLFKPATGFPLGSSLRD 120

Query: 121  SLYFTDNGQIIFPESDYQIFSYPNPLPTGFTGRDPVALVAPFWDDADFSTGRGTTFYQEY 180
            SLYFTDNGQIIFPESDYQIFSYPNPLPTGFTGRDPVALVAPFWDDADFSTGRGTTFYQEY
Sbjct: 121  SLYFTDNGQIIFPESDYQIFSYPNPLPTGFTGRDPVALVAPFWDDADFSTGRGTTFYQEY 180

Query: 181  ETFYGEHSLLVQQAESWIRKMTNNGGYKARWALKVTWVNAHAYPAQWTLGSNTYQAILST 240
            ETFYGEHSLLVQQAESWIRKMTNNGGYKARWALKVTWVNAHAYPAQWTLGSNTYQAILST
Sbjct: 181  ETFYGEHSLLVQQAESWIRKMTNNGGYKARWALKVTWVNAHAYPAQWTLGSNTYQAILST 240

Query: 241  DGSRSYALFLYQSGGMQWDVAQRSGNPVLMGFSSGDGYFENSPLMSQPVWERYRPDRFLN 300
            DGSRSYALFLYQSGGMQWDVAQRSGNPVLMGFSSGDGYFENSPLMSQPVWERYRPDRFLN
Sbjct: 241  DGSRSYALFLYQSGGMQWDVAQRSGNPVLMGFSSGDGYFENSPLMSQPVWERYRPDRFLN 300

Query: 301  SNSGLQGLQFYRLHREERPNYRLECLQWLKSQPRWPSWGWNQVSCPCSWQQGRRDLRFQP 360
            SNSGLQGLQFYRLHREERPNYRLECLQWLKSQPRWPSWGWNQVSCPCSWQQGRRDLRFQP
Sbjct: 301  SNSGLQGLQFYRLHREERPNYRLECLQWLKSQPRWPSWGWNQVSCPCSWQQGRRDLRFQP 360

Query: 361  VSIGRWGLGSRQLCSFTSWRGGVCCSYGPWGEFREGWHVQRPWQLAQELEPQSWCCRWND 420
            VSIGRWGLGSRQLCSFTSWRGGVCCSYGPWGEFREGWHVQRPWQLAQELEPQSWCCRWND
Sbjct: 361  VSIGRWGLGSRQLCSFTSWRGGVCCSYGPWGEFREGWHVQRPWQLAQELEPQSWCCRWND 420

Query: 421  KPYLCALYQQRRPHVGCATYRPPQPAWMFGDPHITTLDGVSYTFNGLGDFLLVGAQDGNS 480
            KPYLCALYQQRRPHVGCATYRPPQPAWMFGDPHITTLDGVSYTFNGLGDFLLVGAQDGNS
Sbjct: 421  KPYLCALYQQRRPHVGCATYRPPQPAWMFGDPHITTLDGVSYTFNGLGDFLLVGAQDGNS 480

Query: 481  SFLLQGRTAQTGSAQATNFIAFAAQYRSSSLGPVTVQWLLEPHDAIRVLLDNQTVTFQPD 540
            SFLLQGRTAQTGSAQATNFIAFAAQYRSSSLGPVTVQWLLEPHDAIRVLLDNQTVTFQPD
Sbjct: 481  SFLLQGRTAQTGSAQATNFIAFAAQYRSSSLGPVTVQWLLEPHDAIRVLLDNQTVTFQPD 540

Query: 541  HEDGGGQETFNATGVLLSRNGSEVSASFDGWATVSVIALSNILHASASLPPEYQNRTEGL 600
            HEDGGGQETFNATGVLLSRNGSEVSASFDGWATVSVIALSNILHASASLPPEYQNRTEGL
Sbjct: 541  HEDGGGQETFNATGVLLSRNGSEVSASFDGWATVSVIALSNILHASASLPPEYQNRTEGL 600

Query: 601  LGVWNNNPEDDFRMPNGSTIPPGSPEEMLFHFGMTWQINGTGLLGKRNDQLPSNFTPVFY 660
            LGVWNNNPEDDFRMPNGSTIPPGSPEEMLFHFGMTWQINGTGLLGKRNDQLPSNFTPVFY
Sbjct: 601  LGVWNNNPEDDFRMPNGSTIPPGSPEEMLFHFGMTWQINGTGLLGKRNDQLPSNFTPVFY 660

Query: 661  SQLQKNSSWAEHLISNCDGDSSCIYDTLALRNASIGLHTREVSKNYEQANATLNQYPPSI 720
            SQLQKNSSWAEHLISNCDGDSSCIYDTLALRNASIGLHTREVSKNYEQANATLNQYPPSI
Sbjct: 661  SQLQKNSSWAEHLISNCDGDSSCIYDTLALRNASIGLHTREVSKNYEQANATLNQYPPSI 720

Query: 721  NGGRVIEAYKGQTTLIQYTSNAEDANFTLRDSCTDLELFENGTLLWTPKSLEPFTLEILA 780
            NGGRVIEAYKGQTTLIQYTSNAEDANFTLRDSCTDLELFENGTLLWTPKSLEPFTLEILA
Sbjct: 721  NGGRVIEAYKGQTTLIQYTSNAEDANFTLRDSCTDLELFENGTLLWTPKSLEPFTLEILA 780

Query: 781  RSAKIGLASALQPRTVVCHCNAESQCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSED 840
            RSAKIGLASALQPRTVVCHCNAESQCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSED
Sbjct: 781  RSAKIGLASALQPRTVVCHCNAESQCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSED 840

Query: 841  ACEEPCFPSVHCVPGKGCEACPPNLTGDGRHCAALGSSFLCQNQSCPVNYCYNQGHCYIS 900
            ACEEPCFPSVHCVPGKGCEACPPNLTGDGRHCAALGSSFLCQNQSCPVNYCYNQGHCYIS
Sbjct: 841  ACEEPCFPSVHCVPGKGCEACPPNLTGDGRHCAALGSSFLCQNQSCPVNYCYNQGHCYIS 900

Query: 901  QTLGCQPMCTCPPAFTDSRCFLAGNNFSPTVNLELPLRVIQLLLSEEENASMAEVNASVA 960
            QTLGCQPMCTCPPAFTDSRCFLAGNNFSPTVNLELPLRVIQLLLSEEENASMAEVNASVA
Sbjct: 901  QTLGCQPMCTCPPAFTDSRCFLAGNNFSPTVNLELPLRVIQLLLSEEENASMAEVNASVA 960

Query: 961  YRLGTLDMRAFLRNSQVERIDSAAPASGSPIQHWMVISEFQYRPRGPVIDFLNNQLLAAV 1020
            YRLGTLDMRAFLRNSQVERIDSAAPASGSPIQHWMVISEFQYRPRGPVIDFLNNQLLAAV
Sbjct: 961  YRLGTLDMRAFLRNSQVERIDSAAPASGSPIQHWMVISEFQYRPRGPVIDFLNNQLLAAV 1020

Query: 1021 VEAFLYHVPRRSEEPRNDVVFQPISGEDVRDVTALNVSTLKAYFRCDGYKGYDLVYSPQS 1080
            VEAFLYHVPRRSEEPRNDVVFQPISGEDVRDVTALNVSTLKAYFRCDGYKGYDLVYSPQS
Sbjct: 1021 VEAFLYHVPRRSEEPRNDVVFQPISGEDVRDVTALNVSTLKAYFRCDGYKGYDLVYSPQS 1080

Query: 1081 GFTCVSPCSRGYCDHGGQCQHLPSGPRCSCVSFSIYTAWGEHCEHLSMKLDAFFGIFFGA 1140
            GFTCVSPCSRGYCDHGGQCQHLPSGPRCSCVSFSIYTAWGEHCEHLSMKLDAFFGIFFGA
Sbjct: 1081 GFTCVSPCSRGYCDHGGQCQHLPSGPRCSCVSFSIYTAWGEHCEHLSMKLDAFFGIFFGA 1140

Query: 1141 LGGLLLLGVGTFVVLRFWGCSGARFSYFLNSAEALP 1176
            LGGLLLLGVGTFVVLRFWGCSGARFSYFLNSAEALP
Sbjct: 1141 LGGLLLLGVGTFVVLRFWGCSGARFSYFLNSAEALP 1176


>gi|167736355 mucin 4 isoform a [Homo sapiens]
          Length = 5284

 Score = 2427 bits (6291), Expect = 0.0
 Identities = 1150/1150 (100%), Positives = 1150/1150 (100%)

Query: 27   PGMTTPSLKTDGGRRTATSPPPTTSQTIISTIPSTAMHTRSTAAPIPILPERGVSLFPYG 86
            PGMTTPSLKTDGGRRTATSPPPTTSQTIISTIPSTAMHTRSTAAPIPILPERGVSLFPYG
Sbjct: 4135 PGMTTPSLKTDGGRRTATSPPPTTSQTIISTIPSTAMHTRSTAAPIPILPERGVSLFPYG 4194

Query: 87   AGAGDLEFVRRTVDFTSPLFKPATGFPLGSSLRDSLYFTDNGQIIFPESDYQIFSYPNPL 146
            AGAGDLEFVRRTVDFTSPLFKPATGFPLGSSLRDSLYFTDNGQIIFPESDYQIFSYPNPL
Sbjct: 4195 AGAGDLEFVRRTVDFTSPLFKPATGFPLGSSLRDSLYFTDNGQIIFPESDYQIFSYPNPL 4254

Query: 147  PTGFTGRDPVALVAPFWDDADFSTGRGTTFYQEYETFYGEHSLLVQQAESWIRKMTNNGG 206
            PTGFTGRDPVALVAPFWDDADFSTGRGTTFYQEYETFYGEHSLLVQQAESWIRKMTNNGG
Sbjct: 4255 PTGFTGRDPVALVAPFWDDADFSTGRGTTFYQEYETFYGEHSLLVQQAESWIRKMTNNGG 4314

Query: 207  YKARWALKVTWVNAHAYPAQWTLGSNTYQAILSTDGSRSYALFLYQSGGMQWDVAQRSGN 266
            YKARWALKVTWVNAHAYPAQWTLGSNTYQAILSTDGSRSYALFLYQSGGMQWDVAQRSGN
Sbjct: 4315 YKARWALKVTWVNAHAYPAQWTLGSNTYQAILSTDGSRSYALFLYQSGGMQWDVAQRSGN 4374

Query: 267  PVLMGFSSGDGYFENSPLMSQPVWERYRPDRFLNSNSGLQGLQFYRLHREERPNYRLECL 326
            PVLMGFSSGDGYFENSPLMSQPVWERYRPDRFLNSNSGLQGLQFYRLHREERPNYRLECL
Sbjct: 4375 PVLMGFSSGDGYFENSPLMSQPVWERYRPDRFLNSNSGLQGLQFYRLHREERPNYRLECL 4434

Query: 327  QWLKSQPRWPSWGWNQVSCPCSWQQGRRDLRFQPVSIGRWGLGSRQLCSFTSWRGGVCCS 386
            QWLKSQPRWPSWGWNQVSCPCSWQQGRRDLRFQPVSIGRWGLGSRQLCSFTSWRGGVCCS
Sbjct: 4435 QWLKSQPRWPSWGWNQVSCPCSWQQGRRDLRFQPVSIGRWGLGSRQLCSFTSWRGGVCCS 4494

Query: 387  YGPWGEFREGWHVQRPWQLAQELEPQSWCCRWNDKPYLCALYQQRRPHVGCATYRPPQPA 446
            YGPWGEFREGWHVQRPWQLAQELEPQSWCCRWNDKPYLCALYQQRRPHVGCATYRPPQPA
Sbjct: 4495 YGPWGEFREGWHVQRPWQLAQELEPQSWCCRWNDKPYLCALYQQRRPHVGCATYRPPQPA 4554

Query: 447  WMFGDPHITTLDGVSYTFNGLGDFLLVGAQDGNSSFLLQGRTAQTGSAQATNFIAFAAQY 506
            WMFGDPHITTLDGVSYTFNGLGDFLLVGAQDGNSSFLLQGRTAQTGSAQATNFIAFAAQY
Sbjct: 4555 WMFGDPHITTLDGVSYTFNGLGDFLLVGAQDGNSSFLLQGRTAQTGSAQATNFIAFAAQY 4614

Query: 507  RSSSLGPVTVQWLLEPHDAIRVLLDNQTVTFQPDHEDGGGQETFNATGVLLSRNGSEVSA 566
            RSSSLGPVTVQWLLEPHDAIRVLLDNQTVTFQPDHEDGGGQETFNATGVLLSRNGSEVSA
Sbjct: 4615 RSSSLGPVTVQWLLEPHDAIRVLLDNQTVTFQPDHEDGGGQETFNATGVLLSRNGSEVSA 4674

Query: 567  SFDGWATVSVIALSNILHASASLPPEYQNRTEGLLGVWNNNPEDDFRMPNGSTIPPGSPE 626
            SFDGWATVSVIALSNILHASASLPPEYQNRTEGLLGVWNNNPEDDFRMPNGSTIPPGSPE
Sbjct: 4675 SFDGWATVSVIALSNILHASASLPPEYQNRTEGLLGVWNNNPEDDFRMPNGSTIPPGSPE 4734

Query: 627  EMLFHFGMTWQINGTGLLGKRNDQLPSNFTPVFYSQLQKNSSWAEHLISNCDGDSSCIYD 686
            EMLFHFGMTWQINGTGLLGKRNDQLPSNFTPVFYSQLQKNSSWAEHLISNCDGDSSCIYD
Sbjct: 4735 EMLFHFGMTWQINGTGLLGKRNDQLPSNFTPVFYSQLQKNSSWAEHLISNCDGDSSCIYD 4794

Query: 687  TLALRNASIGLHTREVSKNYEQANATLNQYPPSINGGRVIEAYKGQTTLIQYTSNAEDAN 746
            TLALRNASIGLHTREVSKNYEQANATLNQYPPSINGGRVIEAYKGQTTLIQYTSNAEDAN
Sbjct: 4795 TLALRNASIGLHTREVSKNYEQANATLNQYPPSINGGRVIEAYKGQTTLIQYTSNAEDAN 4854

Query: 747  FTLRDSCTDLELFENGTLLWTPKSLEPFTLEILARSAKIGLASALQPRTVVCHCNAESQC 806
            FTLRDSCTDLELFENGTLLWTPKSLEPFTLEILARSAKIGLASALQPRTVVCHCNAESQC
Sbjct: 4855 FTLRDSCTDLELFENGTLLWTPKSLEPFTLEILARSAKIGLASALQPRTVVCHCNAESQC 4914

Query: 807  LYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSEDACEEPCFPSVHCVPGKGCEACPPNLT 866
            LYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSEDACEEPCFPSVHCVPGKGCEACPPNLT
Sbjct: 4915 LYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSEDACEEPCFPSVHCVPGKGCEACPPNLT 4974

Query: 867  GDGRHCAALGSSFLCQNQSCPVNYCYNQGHCYISQTLGCQPMCTCPPAFTDSRCFLAGNN 926
            GDGRHCAALGSSFLCQNQSCPVNYCYNQGHCYISQTLGCQPMCTCPPAFTDSRCFLAGNN
Sbjct: 4975 GDGRHCAALGSSFLCQNQSCPVNYCYNQGHCYISQTLGCQPMCTCPPAFTDSRCFLAGNN 5034

Query: 927  FSPTVNLELPLRVIQLLLSEEENASMAEVNASVAYRLGTLDMRAFLRNSQVERIDSAAPA 986
            FSPTVNLELPLRVIQLLLSEEENASMAEVNASVAYRLGTLDMRAFLRNSQVERIDSAAPA
Sbjct: 5035 FSPTVNLELPLRVIQLLLSEEENASMAEVNASVAYRLGTLDMRAFLRNSQVERIDSAAPA 5094

Query: 987  SGSPIQHWMVISEFQYRPRGPVIDFLNNQLLAAVVEAFLYHVPRRSEEPRNDVVFQPISG 1046
            SGSPIQHWMVISEFQYRPRGPVIDFLNNQLLAAVVEAFLYHVPRRSEEPRNDVVFQPISG
Sbjct: 5095 SGSPIQHWMVISEFQYRPRGPVIDFLNNQLLAAVVEAFLYHVPRRSEEPRNDVVFQPISG 5154

Query: 1047 EDVRDVTALNVSTLKAYFRCDGYKGYDLVYSPQSGFTCVSPCSRGYCDHGGQCQHLPSGP 1106
            EDVRDVTALNVSTLKAYFRCDGYKGYDLVYSPQSGFTCVSPCSRGYCDHGGQCQHLPSGP
Sbjct: 5155 EDVRDVTALNVSTLKAYFRCDGYKGYDLVYSPQSGFTCVSPCSRGYCDHGGQCQHLPSGP 5214

Query: 1107 RCSCVSFSIYTAWGEHCEHLSMKLDAFFGIFFGALGGLLLLGVGTFVVLRFWGCSGARFS 1166
            RCSCVSFSIYTAWGEHCEHLSMKLDAFFGIFFGALGGLLLLGVGTFVVLRFWGCSGARFS
Sbjct: 5215 RCSCVSFSIYTAWGEHCEHLSMKLDAFFGIFFGALGGLLLLGVGTFVVLRFWGCSGARFS 5274

Query: 1167 YFLNSAEALP 1176
            YFLNSAEALP
Sbjct: 5275 YFLNSAEALP 5284



 Score = 77.8 bits (190), Expect = 6e-14
 Identities = 41/68 (60%), Positives = 46/68 (67%), Gaps = 2/68 (2%)

Query: 1  MKGARWRRVPWVSLSCLCLCLLPHVVPGMTTPSLKTDGGRRTATSPPPTTSQTIISTIPS 60
          MKGARWRRVPWVSLSCLCLCLLPHVVPG T  +L T  G +TA     T S T      S
Sbjct: 1  MKGARWRRVPWVSLSCLCLCLLPHVVPGTTEDTLIT--GSKTAAPVTSTGSTTATLEGQS 58

Query: 61 TAMHTRST 68
          TA  +R++
Sbjct: 59 TAASSRTS 66


>gi|112382231 mucin 4 isoform e [Homo sapiens]
          Length = 1125

 Score = 2361 bits (6118), Expect = 0.0
 Identities = 1125/1176 (95%), Positives = 1125/1176 (95%), Gaps = 51/1176 (4%)

Query: 1    MKGARWRRVPWVSLSCLCLCLLPHVVPGMTTPSLKTDGGRRTATSPPPTTSQTIISTIPS 60
            MKGARWRRVPWVSLSCLCLCLLPHVVP                                 
Sbjct: 1    MKGARWRRVPWVSLSCLCLCLLPHVVP--------------------------------- 27

Query: 61   TAMHTRSTAAPIPILPERGVSLFPYGAGAGDLEFVRRTVDFTSPLFKPATGFPLGSSLRD 120
                              GVSLFPYGAGAGDLEFVRRTVDFTSPLFKPATGFPLGSSLRD
Sbjct: 28   ------------------GVSLFPYGAGAGDLEFVRRTVDFTSPLFKPATGFPLGSSLRD 69

Query: 121  SLYFTDNGQIIFPESDYQIFSYPNPLPTGFTGRDPVALVAPFWDDADFSTGRGTTFYQEY 180
            SLYFTDNGQIIFPESDYQIFSYPNPLPTGFTGRDPVALVAPFWDDADFSTGRGTTFYQEY
Sbjct: 70   SLYFTDNGQIIFPESDYQIFSYPNPLPTGFTGRDPVALVAPFWDDADFSTGRGTTFYQEY 129

Query: 181  ETFYGEHSLLVQQAESWIRKMTNNGGYKARWALKVTWVNAHAYPAQWTLGSNTYQAILST 240
            ETFYGEHSLLVQQAESWIRKMTNNGGYKARWALKVTWVNAHAYPAQWTLGSNTYQAILST
Sbjct: 130  ETFYGEHSLLVQQAESWIRKMTNNGGYKARWALKVTWVNAHAYPAQWTLGSNTYQAILST 189

Query: 241  DGSRSYALFLYQSGGMQWDVAQRSGNPVLMGFSSGDGYFENSPLMSQPVWERYRPDRFLN 300
            DGSRSYALFLYQSGGMQWDVAQRSGNPVLMGFSSGDGYFENSPLMSQPVWERYRPDRFLN
Sbjct: 190  DGSRSYALFLYQSGGMQWDVAQRSGNPVLMGFSSGDGYFENSPLMSQPVWERYRPDRFLN 249

Query: 301  SNSGLQGLQFYRLHREERPNYRLECLQWLKSQPRWPSWGWNQVSCPCSWQQGRRDLRFQP 360
            SNSGLQGLQFYRLHREERPNYRLECLQWLKSQPRWPSWGWNQVSCPCSWQQGRRDLRFQP
Sbjct: 250  SNSGLQGLQFYRLHREERPNYRLECLQWLKSQPRWPSWGWNQVSCPCSWQQGRRDLRFQP 309

Query: 361  VSIGRWGLGSRQLCSFTSWRGGVCCSYGPWGEFREGWHVQRPWQLAQELEPQSWCCRWND 420
            VSIGRWGLGSRQLCSFTSWRGGVCCSYGPWGEFREGWHVQRPWQLAQELEPQSWCCRWND
Sbjct: 310  VSIGRWGLGSRQLCSFTSWRGGVCCSYGPWGEFREGWHVQRPWQLAQELEPQSWCCRWND 369

Query: 421  KPYLCALYQQRRPHVGCATYRPPQPAWMFGDPHITTLDGVSYTFNGLGDFLLVGAQDGNS 480
            KPYLCALYQQRRPHVGCATYRPPQPAWMFGDPHITTLDGVSYTFNGLGDFLLVGAQDGNS
Sbjct: 370  KPYLCALYQQRRPHVGCATYRPPQPAWMFGDPHITTLDGVSYTFNGLGDFLLVGAQDGNS 429

Query: 481  SFLLQGRTAQTGSAQATNFIAFAAQYRSSSLGPVTVQWLLEPHDAIRVLLDNQTVTFQPD 540
            SFLLQGRTAQTGSAQATNFIAFAAQYRSSSLGPVTVQWLLEPHDAIRVLLDNQTVTFQPD
Sbjct: 430  SFLLQGRTAQTGSAQATNFIAFAAQYRSSSLGPVTVQWLLEPHDAIRVLLDNQTVTFQPD 489

Query: 541  HEDGGGQETFNATGVLLSRNGSEVSASFDGWATVSVIALSNILHASASLPPEYQNRTEGL 600
            HEDGGGQETFNATGVLLSRNGSEVSASFDGWATVSVIALSNILHASASLPPEYQNRTEGL
Sbjct: 490  HEDGGGQETFNATGVLLSRNGSEVSASFDGWATVSVIALSNILHASASLPPEYQNRTEGL 549

Query: 601  LGVWNNNPEDDFRMPNGSTIPPGSPEEMLFHFGMTWQINGTGLLGKRNDQLPSNFTPVFY 660
            LGVWNNNPEDDFRMPNGSTIPPGSPEEMLFHFGMTWQINGTGLLGKRNDQLPSNFTPVFY
Sbjct: 550  LGVWNNNPEDDFRMPNGSTIPPGSPEEMLFHFGMTWQINGTGLLGKRNDQLPSNFTPVFY 609

Query: 661  SQLQKNSSWAEHLISNCDGDSSCIYDTLALRNASIGLHTREVSKNYEQANATLNQYPPSI 720
            SQLQKNSSWAEHLISNCDGDSSCIYDTLALRNASIGLHTREVSKNYEQANATLNQYPPSI
Sbjct: 610  SQLQKNSSWAEHLISNCDGDSSCIYDTLALRNASIGLHTREVSKNYEQANATLNQYPPSI 669

Query: 721  NGGRVIEAYKGQTTLIQYTSNAEDANFTLRDSCTDLELFENGTLLWTPKSLEPFTLEILA 780
            NGGRVIEAYKGQTTLIQYTSNAEDANFTLRDSCTDLELFENGTLLWTPKSLEPFTLEILA
Sbjct: 670  NGGRVIEAYKGQTTLIQYTSNAEDANFTLRDSCTDLELFENGTLLWTPKSLEPFTLEILA 729

Query: 781  RSAKIGLASALQPRTVVCHCNAESQCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSED 840
            RSAKIGLASALQPRTVVCHCNAESQCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSED
Sbjct: 730  RSAKIGLASALQPRTVVCHCNAESQCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSED 789

Query: 841  ACEEPCFPSVHCVPGKGCEACPPNLTGDGRHCAALGSSFLCQNQSCPVNYCYNQGHCYIS 900
            ACEEPCFPSVHCVPGKGCEACPPNLTGDGRHCAALGSSFLCQNQSCPVNYCYNQGHCYIS
Sbjct: 790  ACEEPCFPSVHCVPGKGCEACPPNLTGDGRHCAALGSSFLCQNQSCPVNYCYNQGHCYIS 849

Query: 901  QTLGCQPMCTCPPAFTDSRCFLAGNNFSPTVNLELPLRVIQLLLSEEENASMAEVNASVA 960
            QTLGCQPMCTCPPAFTDSRCFLAGNNFSPTVNLELPLRVIQLLLSEEENASMAEVNASVA
Sbjct: 850  QTLGCQPMCTCPPAFTDSRCFLAGNNFSPTVNLELPLRVIQLLLSEEENASMAEVNASVA 909

Query: 961  YRLGTLDMRAFLRNSQVERIDSAAPASGSPIQHWMVISEFQYRPRGPVIDFLNNQLLAAV 1020
            YRLGTLDMRAFLRNSQVERIDSAAPASGSPIQHWMVISEFQYRPRGPVIDFLNNQLLAAV
Sbjct: 910  YRLGTLDMRAFLRNSQVERIDSAAPASGSPIQHWMVISEFQYRPRGPVIDFLNNQLLAAV 969

Query: 1021 VEAFLYHVPRRSEEPRNDVVFQPISGEDVRDVTALNVSTLKAYFRCDGYKGYDLVYSPQS 1080
            VEAFLYHVPRRSEEPRNDVVFQPISGEDVRDVTALNVSTLKAYFRCDGYKGYDLVYSPQS
Sbjct: 970  VEAFLYHVPRRSEEPRNDVVFQPISGEDVRDVTALNVSTLKAYFRCDGYKGYDLVYSPQS 1029

Query: 1081 GFTCVSPCSRGYCDHGGQCQHLPSGPRCSCVSFSIYTAWGEHCEHLSMKLDAFFGIFFGA 1140
            GFTCVSPCSRGYCDHGGQCQHLPSGPRCSCVSFSIYTAWGEHCEHLSMKLDAFFGIFFGA
Sbjct: 1030 GFTCVSPCSRGYCDHGGQCQHLPSGPRCSCVSFSIYTAWGEHCEHLSMKLDAFFGIFFGA 1089

Query: 1141 LGGLLLLGVGTFVVLRFWGCSGARFSYFLNSAEALP 1176
            LGGLLLLGVGTFVVLRFWGCSGARFSYFLNSAEALP
Sbjct: 1090 LGGLLLLGVGTFVVLRFWGCSGARFSYFLNSAEALP 1125


>gi|10092665 sushi domain containing 2 [Homo sapiens]
          Length = 822

 Score =  140 bits (354), Expect = 5e-33
 Identities = 130/477 (27%), Positives = 189/477 (39%), Gaps = 70/477 (14%)

Query: 322 RLECLQWLKSQPRWPSWGWNQVSCPCSWQQGRRD-----------------LRFQPVSI- 363
           R +C  W + + + P++      CPC+  Q R D                   + P ++ 
Sbjct: 290 RTQCQAWEELEDQLPNFLEELPDCPCTLTQARADSGRFFTDYGCDMEQGSVCTYHPGAVH 349

Query: 364 ------GRWGLGSRQLCSFTS---------WRGGVCCSYG-PWGE--FREGWHVQRPWQL 405
                      GS Q C +T+           GG     G  WG   FR    V      
Sbjct: 350 CVRSVQASLRYGSGQQCCYTADGTQLLTADSSGGSTPDRGHDWGAPPFRTPPRVPSMSHW 409

Query: 406 AQELEPQSWCCRWNDKPYLCALYQQRRPHVGCATYRPPQPAWMFGDPHITTLDGVSYTFN 465
             ++    +CC W      C  Y QRRP   C  YRPP+ A  FGDPH  T DG ++TFN
Sbjct: 410 LYDVLSFYYCCLWAPD---CPRYMQRRPSNDCRNYRPPRLASAFGDPHFVTFDGTNFTFN 466

Query: 466 GLGDFLLVGA--QDGNSSFLLQGRTAQTGS-AQATNFIAFAAQYRSSSLGPVTVQWLLEP 522
           G G+++L+ A   D       Q  T   G+  + T   A A Q  +S +  V    L   
Sbjct: 467 GRGEYVLLEAALTDLRVQARAQPGTMSNGTETRGTGLTAVAVQEGNSDVVEVR---LANR 523

Query: 523 HDAIRVLLDNQTVTFQPDHEDGGGQETFNATGVLLS-RNGSEVSASFDGWATVSVIALSN 581
              + VLL+ + ++F         Q   +  G+ LS   G  VS      A + V     
Sbjct: 524 TGGLEVLLNQEVLSFTE-------QSWMDLKGMFLSVAAGDRVSIMLASGAGLEVSVQGP 576

Query: 582 ILHASASLPPEYQNRTEGLLGVWNNNPEDDFRMPNGSTIPPGSPEEMLFHFGMTWQI-NG 640
            L  S  LP ++   T GLLG  NN+P DDF + +G  +PPG+  + LF FG  W + N 
Sbjct: 577 FLSVSVLLPEKFLTHTHGLLGTLNNDPTDDFTLHSGRVLPPGTSPQELFLFGANWTVHNA 636

Query: 641 TGLLGKRNDQLPSN----------FTPVFYSQLQKNSSWAEHLISNCDGDSSCIYDTLAL 690
           + LL   +  L  N          F P+F S+   N S A+     C  D  C +D  A 
Sbjct: 637 SSLLTYDSWFLVHNFLYQPKHDPTFEPLFPSETTLNPSLAQEAAKLCGDDHFCNFDVAAT 696

Query: 691 RNASIGLHTREVSKNYEQANATLNQ------YPPSINGGRVIEAYKGQTTLIQYTSN 741
            + S G  TR   + +++   +L          P  NG +    Y   +T+  +  N
Sbjct: 697 GSLSTGTATRVAHQLHQRRMQSLQPVVSCGWLAPPPNGQKEGNRYLAGSTIYFHCDN 753


>gi|115298674 nidogen 1 precursor [Homo sapiens]
          Length = 1247

 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 76/267 (28%), Positives = 116/267 (43%), Gaps = 46/267 (17%)

Query: 69  AAPIPILPERGVSLFPYGAGAGDLEFVRRTVDFTSPLFKPATGFPLGSSLR-------DS 121
           A P+  L  +   LFP+G G GDLE +    DF SP  +      L  +LR       D+
Sbjct: 23  AGPVGCLSRQ--ELFPFGPGQGDLE-LEDGDDFVSPALE------LSGALRFYDRSDIDA 73

Query: 122 LYFTDNGQIIFPESDYQIFSYPNPLPTGFTGRDPVALVAPFWDDADFSTGRGTTFYQEYE 181
           +Y T NG I   E   +  S+P   P  F        VAPF  D D + G G  +Y+E  
Sbjct: 74  VYVTTNGIIATSEPPAKE-SHPGLFPPTF------GAVAPFLADLDTTDGLGKVYYREDL 126

Query: 182 TFYGEHSLLVQQAESWIRKMTNNGGYKARWALKVTWVNAHAYPA-----QWTLGSNTYQA 236
           +       + Q+A   + +      ++   A+ VTW +   Y             NT+QA
Sbjct: 127 S-----PSITQRAAECVHRGFPEISFQPSSAVVVTWESVAPYQGPSRDPDQKGKRNTFQA 181

Query: 237 ILSTDGSRSYALFLYQSGGMQWDV--AQRSGN--PVLMGFSSGDGYFENSPLMSQPVWER 292
           +L++  S SYA+FLY   G+Q+    +++  N  P ++ FS G   F      S   +  
Sbjct: 182 VLASSDSSSYAIFLYPEDGLQFHTTFSKKENNQVPAVVAFSQGSVGF---LWKSNGAYNI 238

Query: 293 YRPDR------FLNSNSGLQGLQFYRL 313
           +  DR        +SNSG QG+  + +
Sbjct: 239 FANDRESVENLAKSSNSGQQGVWVFEI 265



 Score = 39.3 bits (90), Expect = 0.022
 Identities = 44/163 (26%), Positives = 56/163 (34%), Gaps = 62/163 (38%)

Query: 807 LYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSEDACEEPCFPSVH-------CVPGK--- 856
           LYNQ  ++   +L          + G   EGS DA + PC+   H       C PG    
Sbjct: 641 LYNQEEKILRYALS--------NSIGPVREGSPDALQNPCYIGTHGCDTNAACRPGPRTQ 692

Query: 857 -GCEACPPNLTGDGRHC----------AALGSSFLCQNQ------------------SC- 886
             CE C     GDGR C          +  GS  +C N                   +C 
Sbjct: 693 FTCE-CSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGTCV 751

Query: 887 ------PVNYCYNQGH-CYISQ------TLGCQPMCTCPPAFT 916
                 P+NYC    H C I Q      T G    C+C P F+
Sbjct: 752 AVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGFS 794



 Score = 32.7 bits (73), Expect = 2.1
 Identities = 23/79 (29%), Positives = 29/79 (36%), Gaps = 12/79 (15%)

Query: 798 CHCNAESQCLYNQTSRVGNSSLEVAGCKCDGGTFG--RYCEGSEDACEEPCFPSVHC--V 853
           C     +QC+Y      G SS     C C  G  G  + C+  ++     C P   C   
Sbjct: 769 CDIPQRAQCIYT-----GGSSYT---CSCLPGFSGDGQACQDVDECQPSRCHPDAFCYNT 820

Query: 854 PGKGCEACPPNLTGDGRHC 872
           PG     C P   GDG  C
Sbjct: 821 PGSFTCQCKPGYQGDGFRC 839



 Score = 32.0 bits (71), Expect = 3.6
 Identities = 23/78 (29%), Positives = 32/78 (41%), Gaps = 12/78 (15%)

Query: 834 YCEGSEDACEEPCFPSVHCVPGKGCE---ACPPNLTGDGRHCAALGSSFLCQNQSC-PVN 889
           YCE     C+ P      C+   G     +C P  +GDG+ C  +     CQ   C P  
Sbjct: 761 YCETGLHNCDIP--QRAQCIYTGGSSYTCSCLPGFSGDGQACQDVDE---CQPSRCHPDA 815

Query: 890 YCYNQGHCYISQTLGCQP 907
           +CYN    +  Q   C+P
Sbjct: 816 FCYNTPGSFTCQ---CKP 830


>gi|144953895 nidogen 2 precursor [Homo sapiens]
          Length = 1375

 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 72/251 (28%), Positives = 109/251 (43%), Gaps = 35/251 (13%)

Query: 82  LFPYGAGAGDLEFVRRTVDFTSPLFKPATGFPLGSSLRDSLYFTDNGQII---FP-ESDY 137
           LFP+G   GD + ++   D +S + K A       +   +LY   NG I    FP E+ Y
Sbjct: 36  LFPHGESWGD-QLLQEGDDESSAVVKLANPLHFYEARFSNLYVGTNGIISTQDFPRETQY 94

Query: 138 QIFSYPNPLPTGFTGRDPVALVAPFWDDADFSTGRGTTFYQEYETFYGEHSLLVQQAESW 197
             + +P   P           +APF  D D S GRG   Y+E  +       ++  A  +
Sbjct: 95  VDYDFPTDFPA----------IAPFLADIDTSHGRGRVLYREDTS-----PAVLGLAARY 139

Query: 198 IRK-MTNNGGYKARWALKVTWVNAHAYPA--QWTLGS---NTYQAILSTDGSRSYALFLY 251
           +R     +  +    A   TW    AY    +  L S   NT+QA+L++DGS SYALFLY
Sbjct: 140 VRAGFPRSARFTPTHAFLATWEQVGAYEEVKRGALPSGELNTFQAVLASDGSDSYALFLY 199

Query: 252 QSGGMQW--DVAQRSGN-----PVLMGFSSG--DGYFENSPLMSQPVWERYRPDRFLNSN 302
            + G+Q+     + S N     P  +GF  G  D      P  S    E+   + +  SN
Sbjct: 200 PANGLQFLGTRPKESYNVQLQLPARVGFCRGEADDLKSEGPYFSLTSTEQSVKNLYQLSN 259

Query: 303 SGLQGLQFYRL 313
            G+ G+  + +
Sbjct: 260 LGIPGVWAFHI 270



 Score = 33.1 bits (74), Expect = 1.6
 Identities = 22/76 (28%), Positives = 28/76 (36%), Gaps = 6/76 (7%)

Query: 832 GRYCEGSEDACEEPCFPSVHC--VPGKGCEACPPNLTGDGRHCAALGSSFL--CQNQS-- 885
           G  C   ++  E  C P+  C   PG     C P   GDG  C    +S L  C+ Q   
Sbjct: 887 GHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPGYYGDGFQCIPDSTSSLTPCEQQQRH 946

Query: 886 CPVNYCYNQGHCYISQ 901
               Y Y     +I Q
Sbjct: 947 AQAQYAYPGARFHIPQ 962


>gi|134268640 tectorin alpha precursor [Homo sapiens]
          Length = 2155

 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 48/153 (31%), Positives = 66/153 (43%), Gaps = 17/153 (11%)

Query: 121 SLYFTDNGQIIFPESDYQIFSYPNPLPTGFTGRDPVALVAPFWDDADFSTG-RGTTFYQE 179
           ++Y  +NG + F     Q        P  F   D  A VAPFW  AD   G RG  +Y+E
Sbjct: 64  TVYVNNNGVVSFNVLVSQF------TPESFPLTDGRAFVAPFW--ADVHNGIRGEIYYRE 115

Query: 180 YETFYGEHSLLVQQAESWIRKMTNN-GGYKARWALKVTWVNAHAYPAQWTLGSNTYQAIL 238
                     ++++A   IRK   +   + A W   VTW     Y    T   NT+QA+L
Sbjct: 116 TM-----EPAILKRATKDIRKYFKDMATFSATWVFIVTWEEVTFYGGSSTTPVNTFQAVL 170

Query: 239 STDGSRSYALFLYQSGGMQWDVAQRSGNPVLMG 271
            +DGS ++ LF Y    + W     SG   L G
Sbjct: 171 VSDGSYTFTLFNYYE--INWTTGTASGGDPLTG 201



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 50/198 (25%), Positives = 76/198 (38%), Gaps = 36/198 (18%)

Query: 448 MFGDPHITTLDGVSYTFNGLGDFLLVGAQDGNSSFLLQGRTAQTGSAQATNFIAFAAQYR 507
           +FG+PH  T DG  + F G            + ++LL  +  QT S    +  A     R
Sbjct: 324 VFGEPHYHTFDGFLFHFQG------------SCAYLLARQCLQTSSLPFFSVEAKNEHRR 371

Query: 508 SSSLG-------PVTVQWLLEPHDAIRVLLDNQTVTFQPDHEDGGGQETFNATGVLLSRN 560
            S++         V    +L P  +   +  N  VT  P   D G  + + +        
Sbjct: 372 GSAVSWVKELSVEVNGYKILIPKGSYGRVKVNDLVTSLPVTLDLGTVKIYQSGISTAVET 431

Query: 561 GSEVSASFDGWATVSVIALSNILHASASLPPEYQNRTEGLLGVWNNNPEDDFRMPNGSTI 620
              +  +FDG             +AS S+P  Y N T GL G +N NP DDF  P+    
Sbjct: 432 DFGLLVTFDGQH-----------YASISVPGSYINSTCGLCGNYNKNPLDDFLRPD---- 476

Query: 621 PPGSPEEMLFHFGMTWQI 638
             G P   +   G +W++
Sbjct: 477 --GRPAMSVLDLGESWRV 492



 Score = 40.8 bits (94), Expect = 0.008
 Identities = 78/312 (25%), Positives = 111/312 (35%), Gaps = 48/312 (15%)

Query: 586  SASLPPEYQNRTEGLLGVWNNNPEDDFRMPNGSTIPPGSPEEMLFHFGMTWQINGTGLLG 645
            S ++P   QN T GL G +N NP+DD  MP G  +   S  E    FG +W    T    
Sbjct: 1226 SITVPRSMQNSTYGLCGRYNGNPDDDLEMPMG--LLASSVNE----FGQSWVKRDTFCQV 1279

Query: 646  KRNDQLPSNFTPVFYSQLQKNSSWAEHLISNCDGDSSCIYDTLALRNASIGLHTREVSKN 705
               D+ PS      +S++Q+  S    LI N              +NA+      +V+  
Sbjct: 1280 GCGDRCPSCAKVEGFSKVQQLCS----LIPN--------------QNAAFSKCHSKVNPT 1321

Query: 706  YEQANATLNQYPPSINGGRVIEAYKGQTTLIQYTSNAEDANFTLRDSCTDLELFENGTLL 765
            +   N     +   I+GG V  A    + L  Y S  +    T+    T    + + T+ 
Sbjct: 1322 FFYKNCL---FDSCIDGGAVQTAC---SWLQNYASTCQTQGITV----TGWRNYTSCTVT 1371

Query: 766  WTPKS-LEPFTLEILARSAKIGLASALQPRTVV-CHCNAESQCLYNQTSRVGNSSLEVAG 823
              P S  E        R A I L S      V  CHC+A    L  ++  + +S     G
Sbjct: 1372 CPPNSHYESCVSVCQPRCAAIRLKSDCSHYCVEGCHCDA-GYVLNGKSCILPHS----CG 1426

Query: 824  CKCDGGTFGRYCEGSEDACEEPCFPSVHCVPGKGCEACPPNLTGDGRHCAALGSSFLCQN 883
            C  D    G+Y E  +      C     C   +    C P        CA       C  
Sbjct: 1427 CYSD----GKYYEPKQLFWNSDCTRRCRCF-RRNVIQCDPRQCKSDEECALRNGVRGC-- 1479

Query: 884  QSCPVNYCYNQG 895
             S   +YC   G
Sbjct: 1480 FSTKTSYCLAAG 1491



 Score = 33.1 bits (74), Expect = 1.6
 Identities = 27/77 (35%), Positives = 36/77 (46%), Gaps = 8/77 (10%)

Query: 546 GQET----FNATGVL-LSRNGSEVSASFDGWATVSVIALSNILHASASLPPEYQNRTEGL 600
           GQE     F+ +G L + RN +  +    G  TV     S+I      L   Y N T GL
Sbjct: 792 GQEVELPFFHPSGKLEIYRNKNSTTVESKGVVTVQY---SDIGLLYIRLSTTYFNCTGGL 848

Query: 601 LGVWNNNPEDDFRMPNG 617
            G +N N  D+F +PNG
Sbjct: 849 CGFYNANASDEFCLPNG 865


>gi|122937283 6720455I24Rik homolog [Homo sapiens]
          Length = 1413

 Score = 57.8 bits (138), Expect = 6e-08
 Identities = 54/205 (26%), Positives = 82/205 (40%), Gaps = 24/205 (11%)

Query: 83  FPYGAGAGDLEFVRRTVDFTSPLFKPATGFPLGSSLRDSLYFTDNGQIIFPESDYQIFSY 142
           +P+GA  GD    ++  D  S L   +  FP   +    LY  +NG I F +   Q    
Sbjct: 32  YPFGAERGDAVTPKQD-DGGSGLRPLSVPFPFFGAEHSGLYVNNNGIISFLKEVSQF--- 87

Query: 143 PNPLPTGFTGRDPVALVAPFWDDADFSTGRGTTFYQEYETFYGEHSLLVQQAESWIRKMT 202
               P  F       +VA FW D D +   G  +Y+E      + ++L +  E       
Sbjct: 88  ---TPVAFPIAKDRCVVAAFWADVD-NRRAGDVYYREAT----DPAMLRRATEDVRHYFP 139

Query: 203 NNGGYKARWALKVTWVNAHAYPAQWTLGSNTYQAILSTDGSRSYALFLYQSGGMQWDV-- 260
               + A W    TW     +    +   NT+Q +L TDG  S+ +F Y+S  + W    
Sbjct: 140 ELLDFNATWVFVATWYRVTFFGGSSSSPVNTFQTVLITDGKLSFTIFNYES--IVWTTGT 197

Query: 261 -AQRSGNPVLM-------GFSSGDG 277
            A   GN   +       GF++GDG
Sbjct: 198 HASSGGNATGLGGIAAQAGFNAGDG 222



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 39/136 (28%), Positives = 50/136 (36%), Gaps = 16/136 (11%)

Query: 799 HCNAESQCLYNQTSRVGNSSLEVAG---CKCDGGTFGRYCEGSEDACE-EPCFPSVHCVP 854
           HC  E         R G S   + G   C+C  G  G +CE   DAC+  PC     C  
Sbjct: 787 HCELERDECRAHPCRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCES 846

Query: 855 GKGCEACPPNLTGDGRHCAALGSSFLCQNQSCPVNYCYNQGHCYISQTLGCQPMCTCPPA 914
           G G   C    +  G HC  +       +  C  + C  +G+C  S        CTC   
Sbjct: 847 GGGAYLCVCPESFFGYHCETV-------SDPCFSSPCGGRGYCLASNG---SHSCTCKVG 896

Query: 915 FTDSRCFLAGNNFSPT 930
           +T   C  A   F PT
Sbjct: 897 YTGEDC--AKELFPPT 910



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 33/113 (29%), Positives = 46/113 (40%), Gaps = 13/113 (11%)

Query: 824 CKCDGGTFGRYCEGSED--ACEEPCFPSVHCVPGKGCEACPPNLTGDGRHCAALGSSFLC 881
           C+C  G  G++CE +        PC     C    G   C       GRHC       + 
Sbjct: 565 CECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCE------IG 618

Query: 882 QNQSCPVNYCYNQGHCYISQTLGCQPMCTCPPAFTDSRCFLAGNNF--SPTVN 932
           +  SC    C+N G C+    +G +  C CPP F+   C +A +    SP VN
Sbjct: 619 KPDSCASGPCHNGGTCF--HYIG-KYKCDCPPGFSGRHCEIAPSPCFRSPCVN 668



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 34/126 (26%), Positives = 46/126 (36%), Gaps = 17/126 (13%)

Query: 800 CNAESQCLYNQTSRVGNSSLEVAG--CKCDGGTFGRYCEGSEDACE-EPCFPSVHC--VP 854
           C    +C        G+    VAG  C C  G  G +CE   D C   PC     C  +P
Sbjct: 751 CLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDECRAHPCRNGGSCRNLP 810

Query: 855 GKGCEACPPNLTGDGRHCAALGSSFLCQNQSCPVNYCYNQGHCYISQTLGCQPMCTCPPA 914
           G     CP      G HC         +  +C  + C + G C   ++ G   +C CP +
Sbjct: 811 GAYVCRCPAGFV--GVHCET-------EVDACDSSPCQHGGRC---ESGGGAYLCVCPES 858

Query: 915 FTDSRC 920
           F    C
Sbjct: 859 FFGYHC 864



 Score = 37.7 bits (86), Expect = 0.065
 Identities = 35/134 (26%), Positives = 43/134 (32%), Gaps = 40/134 (29%)

Query: 798 CHCNAESQCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSEDACEEPCFPSVHCVPGKG 857
           C C    +CL   T+           C+C  G FG  CE    A   PC  +  C     
Sbjct: 472 CECRNGGRCLGANTTL----------CQCPLGFFGLLCEFEITAM--PCNMNTQC----- 514

Query: 858 CEACPPNLTGDGRHCAALGSSFLC-----QNQS------CPVNYCYNQGHCYISQTLGCQ 906
                     DG +C   G S+LC      N S      C  + C+N G C         
Sbjct: 515 ---------PDGGYCMEHGGSYLCVCHTDHNASHSLPSPCDSDPCFNGGSCDAHDD---S 562

Query: 907 PMCTCPPAFTDSRC 920
             C CP  F    C
Sbjct: 563 YTCECPRGFHGKHC 576



 Score = 32.0 bits (71), Expect = 3.6
 Identities = 19/50 (38%), Positives = 20/50 (40%), Gaps = 10/50 (20%)

Query: 1064 FRCDGYKGYDLVYSPQSGFTCV---SPCSRGYCDHGGQCQHLPSGPRCSC 1110
            FRC    G+        G TC    SPC    C HGGQCQ       C C
Sbjct: 333  FRCQCPAGF-------GGPTCETAQSPCDTKECQHGGQCQVENGSAVCVC 375



 Score = 32.0 bits (71), Expect = 3.6
 Identities = 15/37 (40%), Positives = 17/37 (45%), Gaps = 4/37 (10%)

Query: 1088 CSRGYCDHGGQCQHLPSGPRCSCVSFSIYTAWGEHCE 1124
            CS G C +GG C+       CSC     Y   G HCE
Sbjct: 584  CSSGPCRNGGTCKEAGGEYHCSCP----YRFTGRHCE 616



 Score = 30.8 bits (68), Expect = 7.9
 Identities = 31/128 (24%), Positives = 39/128 (30%), Gaps = 18/128 (14%)

Query: 798 CHCN----AESQCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSEDACE-EPCFPSVHC 852
           CH +    A   C    T   G +S     C+C  G  G  CE ++  C+ + C     C
Sbjct: 308 CHLDVNECASQPCQNGGTCTHGINSFR---CQCPAGFGGPTCETAQSPCDTKECQHGGQC 364

Query: 853 VPGKGCEACPPNLTGDGRHCAALGSSFLCQNQSCPVNYCYNQGHCYISQTLGCQPMCTCP 912
               G   C       G  C             C  + C N G C     L     C C 
Sbjct: 365 QVENGSAVCVCQAGYTGAACE-------MDVDDCSPDPCLNGGSCV---DLVGNYTCLCA 414

Query: 913 PAFTDSRC 920
             F   RC
Sbjct: 415 EPFKGLRC 422


>gi|24041035 notch 2 preproprotein [Homo sapiens]
          Length = 2471

 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 38/125 (30%), Positives = 52/125 (41%), Gaps = 19/125 (15%)

Query: 799  HCNAESQCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSEDAC-EEPCFP--SVHCVPG 855
            HC    QC+     R+G  S     C+C  G  G  CEG  + C   PC    S+ C+  
Sbjct: 1234 HCLNGGQCM----DRIGGYS-----CRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQL 1284

Query: 856  KGCEACPPNLTGDGRHCAALGSSFLCQNQSCPVNYCYNQGHCYISQTLGCQPMCTCPPAF 915
                 C       GRHC     +F+     CP   C N G C ++  +    +C CPP F
Sbjct: 1285 TNDYLCVCRSAFTGRHC----ETFV---DVCPQMPCLNGGTCAVASNMPDGFICRCPPGF 1337

Query: 916  TDSRC 920
            + +RC
Sbjct: 1338 SGARC 1342



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 37/122 (30%), Positives = 48/122 (39%), Gaps = 17/122 (13%)

Query: 804  SQCLYNQTSRVGNSSLEVAG--CKCDGGTFGRYCEGSEDAC-EEPCFPSVHCVPGKGCEA 860
            ++CL       G  S  V    CKC  G  G +CE + + C E  CF    CV G    +
Sbjct: 951  NECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFS 1010

Query: 861  --CPPNLTGDGRHCAALGSSFLCQNQSCPVNYCYNQGHCYISQTLGCQPMCTCPPAFTDS 918
              CP   T         GS  L +   C  + C N+G C     LG    C+CP  +T  
Sbjct: 1011 CLCPVGFT---------GSFCLHEINECSSHPCLNEGTCV--DGLGTY-RCSCPLGYTGK 1058

Query: 919  RC 920
             C
Sbjct: 1059 NC 1060



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 42/154 (27%), Positives = 58/154 (37%), Gaps = 39/154 (25%)

Query: 803 ESQCLYNQTSRVGNSSLEVAG--CKCDGGTFGRYCEGSEDAC-------EEPCFPSV--- 850
           +++CL N     G     V G  C C  G  G  C+ + D C       +  CF  +   
Sbjct: 758 KNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGY 817

Query: 851 --HCV---PGKGCEA----CPPNLTGDGRHCAALGS--SFLC------QNQSCPVNY--- 890
             HCV    GK C+     C PN   +   C    +  S+ C      Q Q C ++    
Sbjct: 818 TCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDEC 877

Query: 891 ----CYNQGHCYISQTLGCQPMCTCPPAFTDSRC 920
               C N G C+ +Q      MC CPP F+   C
Sbjct: 878 ISKPCMNHGLCHNTQG---SYMCECPPGFSGMDC 908



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 76/328 (23%), Positives = 114/328 (34%), Gaps = 64/328 (19%)

Query: 803  ESQCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSEDACEE-PCFPSVHCVPGKGCEAC 861
            ES C    T   G +S     C C  G  G +C    + C   PC     CV G G   C
Sbjct: 993  ESSCFNGGTCVDGINSFS---CLCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLGTYRC 1049

Query: 862  PPNLTGDGRHCAALGSSFLCQNQSCPVNYCYNQGHCYISQTLGCQPMCTCPPAFTDSRCF 921
               L   G++C  L +  LC    C      N+G C   +    +  C CP  +  + C 
Sbjct: 1050 SCPLGYTGKNCQTLVN--LCSRSPCK-----NKGTCVQKK---AESQCLCPSGWAGAYCD 1099

Query: 922  LAGNNFSPTVNLELPLRVIQLLLSEEENASMAEVNASVAYRLGTLDMRAFLRNSQVERID 981
            +      P V+ ++      +L+      S   +NA   +         +  +   E++D
Sbjct: 1100 V------PNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQC--PLGYTGSYCEEQLD 1151

Query: 982  SAAPASGSPIQHWMVISEFQYRPRGPVIDFLNNQLLAAVVEAFLYHVPRRSEEPRNDVVF 1041
              A    +P QH    S           DF+       V      +     +E +N    
Sbjct: 1152 ECA---SNPCQHGATCS-----------DFIGGYRCECVPGYQGVNCEYEVDECQN---- 1193

Query: 1042 QPISGEDVRDVTALNVSTLKAYFRCDGYKGYDLVYSPQSGFTC---VSPCSRG-YCDHGG 1097
            QP         T ++   L  +F+C    G         G  C   +  C+RG +C +GG
Sbjct: 1194 QPCQNGG----TCID---LVNHFKCSCPPG-------TRGLLCEENIDDCARGPHCLNGG 1239

Query: 1098 QCQHLPSGPRCSCV-SFSIYTAWGEHCE 1124
            QC     G  C C+  F+     GE CE
Sbjct: 1240 QCMDRIGGYSCRCLPGFA-----GERCE 1262



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 42/135 (31%), Positives = 53/135 (39%), Gaps = 29/135 (21%)

Query: 795 TVVCHCNAESQCLYNQTSRVGNSSLEVAG---CKCDGGTFGRYCEGSEDACEEPCFPSVH 851
           T V  C+    C +      G + L + G   C+C  G  G+YC    D+   PC PS  
Sbjct: 181 TDVNECDIPGHCQH------GGTCLNLPGSYQCQCPQGFTGQYC----DSLYVPCAPSP- 229

Query: 852 CVPGKGCEACPPNLTGDGR-HCAAL----GSSFLCQNQSCPVNYCYNQGHCYIS-QTLGC 905
           CV G  C       TGD    C  L    GS+       CP + C N G C     T  C
Sbjct: 230 CVNGGTCRQ-----TGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNC 284

Query: 906 QPMCTCPPAFTDSRC 920
           +    CPP +T   C
Sbjct: 285 R----CPPQWTGQFC 295



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 40/152 (26%), Positives = 56/152 (36%), Gaps = 37/152 (24%)

Query: 804  SQCLYNQTSRVGN-SSLEVAG---CKCDGGTFGRYCEGSEDACEE-PCFPSVHC-----V 853
            ++CL N  S  G+   +++     C C     GR+CE   D C + PC     C     +
Sbjct: 1266 NECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNM 1325

Query: 854  PGKGCEACPPNLTG-------------DGRHCA--ALGSSFLCQN-----QSCPVNYCYN 893
            P      CPP  +G              G  C   A G    C +       C  + C +
Sbjct: 1326 PDGFICRCPPGFSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASSPCQH 1385

Query: 894  QGHCYISQTLGCQP---MCTCPPAFTDSRCFL 922
             G C+  +    QP    C C P F+ SRC L
Sbjct: 1386 GGSCHPQR----QPPYYSCQCAPPFSGSRCEL 1413



 Score = 39.3 bits (90), Expect = 0.022
 Identities = 38/128 (29%), Positives = 50/128 (39%), Gaps = 19/128 (14%)

Query: 800 CNAESQCLYNQTSRVGNSSLEVAG---CKCDGGTFGRYCEGSEDACEEP--CFPSVHC-- 852
           C     CL +  +  G++   VA    CKC  G  G+ CE   + C+ P  C     C  
Sbjct: 142 CQWTDACLSHPCAN-GSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLN 200

Query: 853 VPGKGCEACPPNLTGDGRHCAALGSSFLCQNQSCPVNYCYNQGHCYISQTLGCQPMCTCP 912
           +PG     CP   T  G++C +L          C  + C N G C   QT      C C 
Sbjct: 201 LPGSYQCQCPQGFT--GQYCDSL-------YVPCAPSPCVNGGTC--RQTGDFTFECNCL 249

Query: 913 PAFTDSRC 920
           P F  S C
Sbjct: 250 PGFEGSTC 257



 Score = 39.3 bits (90), Expect = 0.022
 Identities = 30/108 (27%), Positives = 39/108 (36%), Gaps = 11/108 (10%)

Query: 824 CKCDGGTFGRYCEGSEDACE-EPCFPSVHCVPGKGCEACPPNLTGDGRHCAALGSSFLCQ 882
           C+C  G  G  CE   + C  +PC     C+   G   C       G HC         +
Sbjct: 442 CECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCEL-------E 494

Query: 883 NQSCPVNYCYNQGHCYISQTLGCQPMCTCPPAFTDSRCFLAGNNFSPT 930
              C  N C N G C        +  C CPP FT   C +  ++ S T
Sbjct: 495 INECQSNPCVNNGQCVDKVN---RFQCLCPPGFTGPVCQIDIDDCSST 539



 Score = 39.3 bits (90), Expect = 0.022
 Identities = 17/33 (51%), Positives = 18/33 (54%)

Query: 1080 SGFTCVSPCSRGYCDHGGQCQHLPSGPRCSCVS 1112
            SG  C S C +  C  G QC H  SGPRC C S
Sbjct: 1338 SGARCQSSCGQVKCRKGEQCVHTASGPRCFCPS 1370



 Score = 38.5 bits (88), Expect = 0.038
 Identities = 34/129 (26%), Positives = 44/129 (34%), Gaps = 35/129 (27%)

Query: 824  CKCDGGTFGRYCEGSEDAC-EEPCFPSVHCVPGKGCEA--CPPNLTGD------------ 868
            C+C  G  G  CE   D C   PC     C+ G    +  C P  TGD            
Sbjct: 897  CECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSE 956

Query: 869  ----GRHCAALGSSFLCQNQS-------------CPVNYCYNQGHCYISQTLGCQPMCTC 911
                G  C+   +S+ C+ Q+             C  + C+N G C           C C
Sbjct: 957  PCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGIN---SFSCLC 1013

Query: 912  PPAFTDSRC 920
            P  FT S C
Sbjct: 1014 PVGFTGSFC 1022



 Score = 37.7 bits (86), Expect = 0.065
 Identities = 49/207 (23%), Positives = 60/207 (28%), Gaps = 85/207 (41%)

Query: 788 ASALQPRTVVCHCNAESQCL--YNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSEDACEE- 844
           A ALQ R     C  E  C+  +N T            CKC  G  G YC+   D CE+ 
Sbjct: 23  AHALQCRDGYEPCVNEGMCVTYHNGTGY----------CKCPEGFLGEYCQ-HRDPCEKN 71

Query: 845 ------------------------------------PCFPSVHCVPGKGC---------- 858
                                               PCF S  C+ G  C          
Sbjct: 72  RCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYEC 131

Query: 859 --------------EACPPNLTGDGRHCAALGSSFLCQ------NQSC--PVNYCYNQGH 896
                         +AC  +   +G  C  + + F C+       Q C   VN C   GH
Sbjct: 132 TCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGH 191

Query: 897 CYISQTLGCQP---MCTCPPAFTDSRC 920
           C    T    P    C CP  FT   C
Sbjct: 192 CQHGGTCLNLPGSYQCQCPQGFTGQYC 218



 Score = 36.2 bits (82), Expect = 0.19
 Identities = 28/99 (28%), Positives = 38/99 (38%), Gaps = 10/99 (10%)

Query: 823 GCKCDGGTFGRYCEGSEDACEEPCFPSVHCVPGKGCEACPPNLTGDGRHCAALGSSFLCQ 882
           GC C  G  G  C  + D C    F S  C PG     C   +      C    +  LC 
Sbjct: 323 GCVCVNGWSGDDCSENIDDC---AFAS--CTPGS---TCIDRVASFSCMCPEGKAGLLCH 374

Query: 883 -NQSCPVNYCYNQGHCYISQTLGCQPMCTCPPAFTDSRC 920
            + +C  N C+    C  +   G Q +CTCP  +  + C
Sbjct: 375 LDDACISNPCHKGALCDTNPLNG-QYICTCPQGYKGADC 412



 Score = 33.9 bits (76), Expect = 0.94
 Identities = 21/70 (30%), Positives = 32/70 (45%), Gaps = 9/70 (12%)

Query: 1058 STLKAYFRCDGYKGYDLVYSPQSGFTCVSPCS-RGYCDHGGQCQHLPSGPRCSCVSFSIY 1116
            +T+   F C    G+    + Q   T V+ C   G+C HGG C +LP   +C C      
Sbjct: 160  TTVANQFSCKCLTGF----TGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQ---- 211

Query: 1117 TAWGEHCEHL 1126
               G++C+ L
Sbjct: 212  GFTGQYCDSL 221



 Score = 33.9 bits (76), Expect = 0.94
 Identities = 35/122 (28%), Positives = 47/122 (38%), Gaps = 18/122 (14%)

Query: 804 SQCLYNQTSRVGNSSLEVAG--CKCDGGTFGRYCEGSEDACEEPCFPSVHCVPGKGCEAC 861
           ++CL N     GN +  ++G  C CD G  G  CE  ++ C      S  C  G  C+  
Sbjct: 722 NECLSNPCIH-GNCTGGLSGYKCLCDAGWVGINCEVDKNEC-----LSNPCQNGGTCD-- 773

Query: 862 PPNLTGDGRHCAALG-SSFLCQ--NQSCPVNYCYNQGHCYISQTLGCQPMCTCPPAFTDS 918
             NL    R     G   + CQ     C  N C NQG C+   +      C C   +T  
Sbjct: 774 --NLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDIS---GYTCHCVLPYTGK 828

Query: 919 RC 920
            C
Sbjct: 829 NC 830



 Score = 33.5 bits (75), Expect = 1.2
 Identities = 29/98 (29%), Positives = 36/98 (36%), Gaps = 12/98 (12%)

Query: 824 CKCDGGTFGRYCEGSEDACE-EPCFPSVHCVPGKGCEACPPNLTGDGRHCAALGSSFLCQ 882
           C+C  G  G  CE + D C+ +PC     C  G     C  N    G  C+        Q
Sbjct: 556 CQCATGFTGVLCEENIDNCDPDPCHHG-QCQDGIDSYTCICNPGYMGAICSD-------Q 607

Query: 883 NQSCPVNYCYNQGHCYISQTLGCQPMCTCPPAFTDSRC 920
              C  + C N G C I    G Q  C C P  +   C
Sbjct: 608 IDECYSSPCLNDGRC-IDLVNGYQ--CNCQPGTSGVNC 642



 Score = 33.5 bits (75), Expect = 1.2
 Identities = 27/101 (26%), Positives = 34/101 (33%), Gaps = 18/101 (17%)

Query: 824 CKCDGGTFGRYCEGSEDAC-EEPCFPSVHCVP---GKGCEACPPNLTGDGRHCAALGSSF 879
           C C+ G  G  C    D C   PC     C+    G  C  C P  +G   +C       
Sbjct: 593 CICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCN-CQPGTSGV--NCEINFDD- 648

Query: 880 LCQNQSCPVNYCYNQGHCYISQTLGCQPMCTCPPAFTDSRC 920
            C +  C    C +  + Y          C C P FT  RC
Sbjct: 649 -CASNPCIHGICMDGINRY---------SCVCSPGFTGQRC 679


>gi|55770876 notch4 preproprotein [Homo sapiens]
          Length = 2003

 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 45/166 (27%), Positives = 69/166 (41%), Gaps = 24/166 (14%)

Query: 771 LEPFTLEILARSAKIGLASALQPRTVVCHCNAESQCLYNQTSRVGNSSLEVAGCKCDGGT 830
           ++P +L +L     +   S ++PR ++C    E  C    T    + SL    C+C  G 
Sbjct: 1   MQPPSLLLLLLLLLLLCVSVVRPRGLLCGSFPEP-CANGGTCL--SLSLGQGTCQCAPGF 57

Query: 831 FGRYCEGSEDACEEPCFPSVHCVPGKGCEACPPNLTGDGRHCAALGSSFLCQ-------- 882
            G  C+       +PC  +  C  G  C+A  P   G     + L  SFLC         
Sbjct: 58  LGETCQ-----FPDPCQNAQLCQNGGSCQALLPAPLGLPSSPSPLTPSFLCTCLPGFTGE 112

Query: 883 ------NQSCPVNYCYNQGHCYISQTLGCQPMCTCPPAFTDSRCFL 922
                    CP ++C  +G C+I Q  G +P C+C P +T  +C L
Sbjct: 113 RCQAKLEDPCPPSFCSKRGRCHI-QASG-RPQCSCMPGWTGEQCQL 156



 Score = 47.4 bits (111), Expect = 8e-05
 Identities = 38/143 (26%), Positives = 54/143 (37%), Gaps = 14/143 (9%)

Query: 786  GLASALQPRTVVCHCNAE-SQCLYNQTSRVGNSSLEVAG----CKCDGGTFGRYCEGSED 840
            G   A  P  V   C  +  +CL       G ++         C+C  G  G++CE   D
Sbjct: 989  GFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEID 1048

Query: 841  ACE-EPCFPSVHCVPGKGCEACPPNLTGDGRHCAALGSSFLCQNQ--SCPVNYCYNQGHC 897
             C  +PCF       G  CEA   +  G   HC        C ++  SC  ++C++ G C
Sbjct: 1049 PCHSQPCFH------GGTCEATAGSPLGFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLC 1102

Query: 898  YISQTLGCQPMCTCPPAFTDSRC 920
              S   G  P C C   +    C
Sbjct: 1103 LPSPKPGFPPRCACLSGYGGPDC 1125



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 60/254 (23%), Positives = 78/254 (30%), Gaps = 53/254 (20%)

Query: 718 PSINGGRVIEAYKGQTTLIQYTSNAEDANFTLRDSCTDLELFENG--------TLLWTPK 769
           P  NGG  +    GQ T  Q             D C + +L +NG          L  P 
Sbjct: 34  PCANGGTCLSLSLGQGTC-QCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAPLGLPS 92

Query: 770 SLEPFTLEILARSAKIGLASALQPRTVVCHCNAESQCLYNQTSRVGNSSLEVAG---CKC 826
           S  P T   L       L      R   C    E  C  +  S+ G   ++ +G   C C
Sbjct: 93  SPSPLTPSFLCTC----LPGFTGER---CQAKLEDPCPPSFCSKRGRCHIQASGRPQCSC 145

Query: 827 DGGTFGRYCEGSEDACEEPC---------FPSV--HCVPGKGCEACP---------PNLT 866
             G  G  C+  +     PC         +P +  HC PG    AC          P   
Sbjct: 146 MPGWTGEQCQLRDFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPC 205

Query: 867 GDGRHCAALGSSFLC-------------QNQSCPVNYCYNQGHCYISQTLGCQ-PMCTCP 912
             G  C     SF C             +   CP   C N G C +         +C CP
Sbjct: 206 PKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCP 265

Query: 913 PAFTDSRCFLAGNN 926
           P F    C +  +N
Sbjct: 266 PGFIGPDCEVNPDN 279



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 39/135 (28%), Positives = 51/135 (37%), Gaps = 27/135 (20%)

Query: 798 CHCNAESQCLYNQTS----RVGNSSLEVAG---CKCDGGTFGRYCEGSEDAC-EEPCFPS 849
           CH + + +CL  Q        G S L   G   C C  G  G  CE   + C  +PC P 
Sbjct: 429 CHQDLD-ECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNECLSQPCHPG 487

Query: 850 VHCVPGKGCE--ACPPNLTGDGRHCAALGSSFLCQNQS--CPVNYCYNQGHCYISQTLGC 905
             C+         CPP L G            LC+ ++  C    C N   C+     G 
Sbjct: 488 STCLDLLATFHCLCPPGLEGQ-----------LCEVETNECASAPCLNHADCH-DLLNGF 535

Query: 906 QPMCTCPPAFTDSRC 920
           Q  C C P F+ +RC
Sbjct: 536 Q--CICLPGFSGTRC 548



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 35/132 (26%), Positives = 46/132 (34%), Gaps = 36/132 (27%)

Query: 824  CKCDGGTFGRYCEGSEDACE-EPCFPSVHCVPGKG---CEACPPNLTG------------ 867
            C+C  G  G+ C    DAC+ +PC     C P  G   C ACPP   G            
Sbjct: 954  CQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHC-ACPPGFVGLRCEGDVDECLD 1012

Query: 868  ------DGRHCAALGSSFLCQ------NQSCPVNY-------CYNQGHCYISQTLGCQPM 908
                      C +L ++F CQ       Q C V         C++ G C  +       +
Sbjct: 1013 QPCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLGFI 1072

Query: 909  CTCPPAFTDSRC 920
            C CP  F    C
Sbjct: 1073 CHCPKGFEGPTC 1084



 Score = 40.4 bits (93), Expect = 0.010
 Identities = 36/129 (27%), Positives = 46/129 (35%), Gaps = 20/129 (15%)

Query: 796 VVCHCNAESQCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSEDACEEPCFPSVHC--- 852
           +   C   S C+     RVG+ S     C C  G  G  C   +    +PC     C   
Sbjct: 360 IAATCAPGSTCI----DRVGSFS-----CLCPPGRTGLLCHLEDMCLSQPCHGDAQCSTN 410

Query: 853 -VPGKGCEACPPNLTGDGRHCAALGSSFLCQNQSCPVNYCYNQGHCYISQTLGCQPMCTC 911
            + G     C P  +G   H   L    + Q    P   C + G C    T G    C C
Sbjct: 411 PLTGSTLCLCQPGYSGPTCH-QDLDECLMAQQGPSP---CEHGGSCL--NTPGSFN-CLC 463

Query: 912 PPAFTDSRC 920
           PP +T SRC
Sbjct: 464 PPGYTGSRC 472



 Score = 40.4 bits (93), Expect = 0.010
 Identities = 32/103 (31%), Positives = 38/103 (36%), Gaps = 17/103 (16%)

Query: 822 AGCKCDGGTFGRYCEGSEDAC-EEPCFPSVHCVP---GKGCEACPPNLTGDGRHCAALGS 877
           + C CD G  G  CE     C   PC     C P   G  C  CP   TG    C+    
Sbjct: 675 SSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNC-TCPTGYTGPT--CSE--- 728

Query: 878 SFLCQNQSCPVNYCYNQGHCYISQTLGCQPMCTCPPAFTDSRC 920
               +  +C    C N G C  S        CTCPP+ T  +C
Sbjct: 729 ----EMTACHSGPCLNGGSCNPSPG---GYYCTCPPSHTGPQC 764



 Score = 38.5 bits (88), Expect = 0.038
 Identities = 36/124 (29%), Positives = 48/124 (38%), Gaps = 12/124 (9%)

Query: 802 AESQCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSEDAC-EEPCFPSVHCV---PGKG 857
           A+S C    T +    S +   C C  G  G  C+   D C ++PC  + HC+   P   
Sbjct: 811 ADSPCRNRATCQ---DSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFH 867

Query: 858 CEACPPNLTGDGRHCAALGSSFLCQNQSCPVN-YCYNQGHCYISQTLGCQPMCTCPPAFT 916
           C  C    TG   +           +Q   V+  C+N G C  S   G    C CPP F 
Sbjct: 868 C-LCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDS---GPSYFCHCPPGFQ 923

Query: 917 DSRC 920
            S C
Sbjct: 924 GSLC 927



 Score = 34.3 bits (77), Expect = 0.72
 Identities = 26/92 (28%), Positives = 33/92 (35%), Gaps = 17/92 (18%)

Query: 824 CKCDGGTFGRYCEGSEDAC-EEPCFPSVHC--VPGKGCEACPPNLTGDGRHCAALGSSFL 880
           CKC  G  G  C+   D C  +PC     C  +PG     CP   TG            L
Sbjct: 575 CKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQ-----------L 623

Query: 881 CQNQSCPVNYCYNQGHCYISQTLGCQPMCTCP 912
           C+   C  N C  +  C   +    +  C CP
Sbjct: 624 CEVPLCAPNLCQPKQICKDQKD---KANCLCP 652


>gi|9506545 delta-like 4 protein precursor [Homo sapiens]
          Length = 685

 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 43/134 (32%), Positives = 53/134 (39%), Gaps = 26/134 (19%)

Query: 800 CNAE-SQCLYNQTSRVGNSSLEVAG--CKCDGGTFGRYCEGSEDAC-EEPCFPSVHCVPG 855
           C  E S+C  N     G+   +  G  C C  G +G +CE S  +C + PCF    C   
Sbjct: 321 CELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRER 380

Query: 856 K-----GCEACPPNLTGDGRHCAALGSSFLCQNQ--SCPVNYCYNQGHCYISQTLGCQPM 908
                  CE CPPN TG             C+ +   C  N C N G C      G   M
Sbjct: 381 NQGANYACE-CPPNFTGSN-----------CEKKVDRCTSNPCANGGQCL---NRGPSRM 425

Query: 909 CTCPPAFTDSRCFL 922
           C C P FT + C L
Sbjct: 426 CRCRPGFTGTYCEL 439



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 39/126 (30%), Positives = 44/126 (34%), Gaps = 17/126 (13%)

Query: 799 HCNAESQCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSEDACEE-PCFPSVHCVP--- 854
           +C   S C    T    NS      C C  G  G  CE     C+  PC     C     
Sbjct: 287 YCTHHSPCKNGATC--SNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQED 344

Query: 855 GKGCEACPPNLTGDGRHCAALGSSFLCQNQSCPVNYCYNQGHCYISQTLGCQPMCTCPPA 914
           G  C  CPP   G   HC            SC  + C+N G C   +  G    C CPP 
Sbjct: 345 GYHC-LCPPGYYG--LHCEH-------STLSCADSPCFNGGSCR-ERNQGANYACECPPN 393

Query: 915 FTDSRC 920
           FT S C
Sbjct: 394 FTGSNC 399



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 34/122 (27%), Positives = 43/122 (35%), Gaps = 16/122 (13%)

Query: 800 CNAESQCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCE-GSEDACEEPCFPSVHCVPGKGC 858
           C    QCL    SR+         C+C  G  G YCE    D    PC     C   +  
Sbjct: 411 CANGGQCLNRGPSRM---------CRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENG 461

Query: 859 EACPPNLTGDGRHCAALGSSFLCQNQSCPVNYCYNQGHCYISQTLGCQPMCTCPPAFTDS 918
             C       GR C    S       +C  + C+N+  CY   +     +C CP  F  S
Sbjct: 462 LMCTCPAGFSGRRCEVRTSI-----DACASSPCFNRATCYTDLSTDTF-VCNCPYGFVGS 515

Query: 919 RC 920
           RC
Sbjct: 516 RC 517



 Score = 35.4 bits (80), Expect = 0.32
 Identities = 18/41 (43%), Positives = 21/41 (51%), Gaps = 6/41 (14%)

Query: 1085 VSPCSRGYCDHGGQCQHLPSGPRCSC-VSFSIYTAWGEHCE 1124
            VS C+R  C HGG C  L +G  C+C   FS     G  CE
Sbjct: 441  VSDCARNPCAHGGTCHDLENGLMCTCPAGFS-----GRRCE 476



 Score = 32.0 bits (71), Expect = 3.6
 Identities = 19/65 (29%), Positives = 27/65 (41%), Gaps = 8/65 (12%)

Query: 1068 GYKGYDLVYSP-QSGFTC---VSPCSRGYCDHGGQCQHLPSGPRCSCVSFSIYTAWGEHC 1123
            G + Y     P  +G  C   +S C    C +GG C+    G  C C        +G HC
Sbjct: 304  GQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPP----GYYGLHC 359

Query: 1124 EHLSM 1128
            EH ++
Sbjct: 360  EHSTL 364



 Score = 30.8 bits (68), Expect = 7.9
 Identities = 33/137 (24%), Positives = 45/137 (32%), Gaps = 23/137 (16%)

Query: 797 VCHCNAESQCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSEDACEEPCFPSV---HCV 853
           VC  +    CL   T       + ++GC    G    YC    +    P +       C+
Sbjct: 199 VCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNG----YCSKPAECLCRPGWQGRLCNECI 254

Query: 854 PGKGCE----ACPPNLTGDGRHCAALGSSFLCQNQSCPVNYCYNQGHCYISQTLGCQPM- 908
           P  GC     + P   T D       G  F  Q+    +NYC +   C    T       
Sbjct: 255 PHNGCRHGTCSTPWQCTCD----EGWGGLFCDQD----LNYCTHHSPCKNGATCSNSGQR 306

Query: 909 ---CTCPPAFTDSRCFL 922
              CTC P +T   C L
Sbjct: 307 SYTCTCRPGYTGVDCEL 323


>gi|154146262 Fc fragment of IgG binding protein [Homo sapiens]
          Length = 5405

 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 68/275 (24%), Positives = 103/275 (37%), Gaps = 52/275 (18%)

Query: 381  GGVCCSYGPWGEFREGWHVQRPWQLAQELEPQSWC---CRWND------KPYLCALYQQR 431
            G  C   G  G      H  R + L Q   P   C   CR  +      +P  C  ++  
Sbjct: 2381 GDTCVPVGQCGCL----HDDRYYPLGQTFYPGPGCDSLCRCREGGEVSCEPSSCGPHETC 2436

Query: 432  RPH---VGCATYRPPQPAWMFGDPHITTLDGVSYTFNGLGDFLLV---GAQDGNSSFLLQ 485
            RP    +GC            GDPH TT DG  + F G   ++L    G + G   F + 
Sbjct: 2437 RPSGGSLGCVAVGSTT-CQASGDPHYTTFDGRRFDFMGTCVYVLAQTCGTRPGLHRFAVL 2495

Query: 486  GRTAQTGSAQATNFIAFAAQYRSSSLGPVTVQWLLEPHDA---IRVLLDNQTVTFQPDHE 542
                  G+ + +       Q  + +L     QW +  +     + V+L N          
Sbjct: 2496 QENVAWGNGRVSVTRVITVQVANFTLRLEQRQWKVTVNGVDMKLPVVLAN---------- 2545

Query: 543  DGGGQETFNATGVLLSRNGSEVSASFDGWATVSVIALSNILHASASLPPEYQNRTEGLLG 602
               GQ       +  S++GS+V    D    V   A   + +   ++P  Y     GL G
Sbjct: 2546 ---GQ-------IRASQHGSDVVIETDFGLRV---AYDLVYYVRVTVPGNYYQLMCGLCG 2592

Query: 603  VWNNNPEDDFRMPNGSTIPPGSPEEMLFHFGMTWQ 637
             +N +P+DDF+ PNGS    G+  E    FG +W+
Sbjct: 2593 NYNGDPKDDFQKPNGS--QAGNANE----FGNSWE 2621



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 68/275 (24%), Positives = 103/275 (37%), Gaps = 52/275 (18%)

Query: 381  GGVCCSYGPWGEFREGWHVQRPWQLAQELEPQSWC---CRWND------KPYLCALYQQR 431
            G  C   G  G      H  R + L Q   P   C   CR  +      +P  C  ++  
Sbjct: 3582 GDTCVPVGQCGCL----HDDRYYPLGQTFYPGPGCDSLCRCREGGEVSCEPSSCGPHETC 3637

Query: 432  RPH---VGCATYRPPQPAWMFGDPHITTLDGVSYTFNGLGDFLLV---GAQDGNSSFLLQ 485
            RP    +GC            GDPH TT DG  + F G   ++L    G + G   F + 
Sbjct: 3638 RPSGGSLGCVAVGSTT-CQASGDPHYTTFDGHRFDFMGTCVYVLAQTCGTRPGLHRFAVL 3696

Query: 486  GRTAQTGSAQATNFIAFAAQYRSSSLGPVTVQWLLEPHDA---IRVLLDNQTVTFQPDHE 542
                  G+ + +       Q  + +L     QW +  +     + V+L N          
Sbjct: 3697 QENVAWGNGRVSVTRVITVQVANFTLRLEQRQWKVTVNGVDMKLPVVLAN---------- 3746

Query: 543  DGGGQETFNATGVLLSRNGSEVSASFDGWATVSVIALSNILHASASLPPEYQNRTEGLLG 602
               GQ       +  S++GS+V    D    V   A   + +   ++P  Y     GL G
Sbjct: 3747 ---GQ-------IRASQHGSDVVIETDFGLRV---AYDLVYYVRVTVPGNYYQLMCGLCG 3793

Query: 603  VWNNNPEDDFRMPNGSTIPPGSPEEMLFHFGMTWQ 637
             +N +P+DDF+ PNGS    G+  E    FG +W+
Sbjct: 3794 NYNGDPKDDFQKPNGS--QAGNANE----FGNSWE 3822



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 50/194 (25%), Positives = 80/194 (41%), Gaps = 35/194 (18%)

Query: 450  GDPHITTLDGVSYTFNGLGDFLLV---GAQDGNSSFLLQGRTAQTGSAQATNFIAFAAQY 506
            GDPH TT DG  + F G   ++L    G + G   F +       G+ + +       Q 
Sbjct: 1256 GDPHYTTFDGRRFDFMGTCVYVLAQTCGTRPGLHRFAVLQENVAWGNGRVSVTRVITVQV 1315

Query: 507  RSSSLGPVTVQWLLEPHDA---IRVLLDNQTVTFQPDHEDGGGQETFNATGVLLSRNGSE 563
             + +L     QW +  +     + V+L N             GQ       +  S++GS+
Sbjct: 1316 ANFTLRLEQRQWKVTVNGVDMKLPVVLAN-------------GQ-------IRASQHGSD 1355

Query: 564  VSASFDGWATVSVIALSNILHASASLPPEYQNRTEGLLGVWNNNPEDDFRMPNGSTIPPG 623
            V    D    V   A   + +   ++P  Y  +  GL G +N +P+DDF+ PNGS    G
Sbjct: 1356 VVIETDFGLRV---AYDLVYYVRVTVPGNYYQQMCGLCGNYNGDPKDDFQKPNGS--QAG 1410

Query: 624  SPEEMLFHFGMTWQ 637
            +  E    FG +W+
Sbjct: 1411 NANE----FGNSWE 1420



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 50/198 (25%), Positives = 74/198 (37%), Gaps = 38/198 (19%)

Query: 450 GDPHITTLDGVSYTFNGLGDFLLV---GAQDGNSSFLLQGRTAQTGSAQATNFIAFAAQY 506
           GDPH TT DG  Y   G   + +V      D   +F ++ +    GS             
Sbjct: 476 GDPHYTTFDGRRYDMMGTCSYTMVELCSEDDTLPAFSVEAKNEHRGSR------------ 523

Query: 507 RSSSLGPVTVQWLLEPHDAIR-----VLLDNQTVTFQPDHEDGGGQETFNATGVLLSRNG 561
           R S +G VTV+         R     VL+DNQ         +G          V  S   
Sbjct: 524 RVSYVGLVTVRAYSHSVSLTRGEVGFVLVDNQRSRLPVSLSEG-------RLRVYQSGPR 576

Query: 562 SEVSASFDGWATVSVIALSNILHASASLPPEYQNRTEGLLGVWNNNPEDDFRMPNGSTIP 621
           + V   F       V+        + SLP  +Q++  GL G +N +P DDF  P+G+  P
Sbjct: 577 AVVELVFG-----LVVTYDWDCQLALSLPARFQDQVCGLCGNYNGDPADDFLTPDGALAP 631

Query: 622 PGSPEEMLFHFGMTWQIN 639
                     F  +W+++
Sbjct: 632 DA------VEFASSWKLD 643



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 49/196 (25%), Positives = 78/196 (39%), Gaps = 23/196 (11%)

Query: 447  WMFGDPHITTLDGVSYTFNGLGDFLLVGAQDGNSSFLLQGRTAQTGSAQATNFIAFAAQY 506
            W++GDPH  + DG  + F G  +++L  A  G      QG T  T + +  N    A  Y
Sbjct: 1674 WLWGDPHYHSFDGRKFDFQGTCNYVL--ATTGCPGVSTQGLTPFTVTTKNQNRGNPAVSY 1731

Query: 507  -RSSSLGPVTVQWLLEPHDAIRVLLDNQTVTFQPDHEDGGGQETFNATGVLLSRN-GSEV 564
             R  ++  +     +   +  +V ++           DG    T  A+  LL  + G +V
Sbjct: 1732 VRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVTQGASKALLVADFGLQV 1791

Query: 565  SASFDGWATVSVIALSNILHASASLPPEYQNRTEGLLGVWNNNPEDDFRMPNGSTIPPGS 624
            S  ++ W                +LP  Y     GL G  + NP +D   PNG T+ P  
Sbjct: 1792 SYDWN-W------------RVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNG-TLAPSI 1837

Query: 625  PEEMLFHFGMTWQING 640
            P      +G +W+  G
Sbjct: 1838 P-----IWGGSWRAPG 1848



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 49/196 (25%), Positives = 78/196 (39%), Gaps = 23/196 (11%)

Query: 447  WMFGDPHITTLDGVSYTFNGLGDFLLVGAQDGNSSFLLQGRTAQTGSAQATNFIAFAAQY 506
            W++GDPH  + DG  + F G  +++L  A  G      QG T  T + +  N    A  Y
Sbjct: 2875 WLWGDPHYHSFDGRKFDFQGTCNYVL--ATTGCPGVSTQGLTPFTVTTKNQNRGNPAVSY 2932

Query: 507  -RSSSLGPVTVQWLLEPHDAIRVLLDNQTVTFQPDHEDGGGQETFNATGVLLSRN-GSEV 564
             R  ++  +     +   +  +V ++           DG    T  A+  LL  + G +V
Sbjct: 2933 VRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVTQGASKALLVADFGLQV 2992

Query: 565  SASFDGWATVSVIALSNILHASASLPPEYQNRTEGLLGVWNNNPEDDFRMPNGSTIPPGS 624
            S  ++ W                +LP  Y     GL G  + NP +D   PNG T+ P  
Sbjct: 2993 SYDWN-W------------RVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNG-TLAPSI 3038

Query: 625  PEEMLFHFGMTWQING 640
            P      +G +W+  G
Sbjct: 3039 P-----IWGGSWRAPG 3049



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 48/196 (24%), Positives = 77/196 (39%), Gaps = 23/196 (11%)

Query: 447  WMFGDPHITTLDGVSYTFNGLGDFLLVGAQDGNSSFLLQGRTAQTGSAQATNFIAFAAQY 506
            W++GDPH  + DG  + F G  +++L  A  G      QG T  T + +  N    A  Y
Sbjct: 4076 WLWGDPHYHSFDGRKFDFQGTCNYVL--ATTGCPGVSTQGLTPFTVTTKNQNRGNPAVSY 4133

Query: 507  -RSSSLGPVTVQWLLEPHDAIRVLLDNQTVTFQPDHEDGGGQETFNATGVLLSRN-GSEV 564
             R  ++  +     +   +  +V ++           DG       A+  LL  + G +V
Sbjct: 4134 VRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVAQGASKALLVADFGLQV 4193

Query: 565  SASFDGWATVSVIALSNILHASASLPPEYQNRTEGLLGVWNNNPEDDFRMPNGSTIPPGS 624
            S  ++ W                +LP  Y     GL G  + NP +D   PNG T+ P  
Sbjct: 4194 SYDWN-W------------RVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNG-TLAPSI 4239

Query: 625  PEEMLFHFGMTWQING 640
            P      +G +W+  G
Sbjct: 4240 P-----IWGGSWRAPG 4250



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 45/188 (23%), Positives = 76/188 (40%), Gaps = 22/188 (11%)

Query: 450  GDPHITTLDGVSYTFNGLGDFLLVGAQDGNSSFLLQGRTAQTGSAQATNFIAFAAQYRSS 509
            GDPH  + DG  + F G   +LLVG+  G ++ L   R       + +  +++    R  
Sbjct: 868  GDPHYVSFDGRRFDFMGTCTYLLVGS-CGQNAALPAFRVLVENEHRGSQTVSYTRAVRVE 926

Query: 510  SLGPVTVQWLLEPHDAIRVLLDNQTVTFQPDHEDGGGQETFNATGVLLSRNGSEVSASFD 569
            + G   V+  +      +VL+D+  + + P     G  + F      + R    ++ ++D
Sbjct: 927  ARG---VKVAVRREYPGQVLVDD-VLQYLPFQAADGQVQVFRQGRDAVVRTDFGLTVTYD 982

Query: 570  GWATVSVIALSNILHASASLPPEYQNRTEGLLGVWNNNPEDDFRMPNGSTIPPGSPEEML 629
              A V           +A +P  Y     GL G +N +P DD  +  G     G     L
Sbjct: 983  WNARV-----------TAKVPSSYAEALCGLCGNFNGDPADDLALRGG-----GQAANAL 1026

Query: 630  FHFGMTWQ 637
              FG +WQ
Sbjct: 1027 -AFGNSWQ 1033



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 55/218 (25%), Positives = 81/218 (37%), Gaps = 43/218 (19%)

Query: 446  AWMFGDPHITTLDGVSYTFNGLGDFLLV----GAQDGNSSFLLQGRTAQTGSAQATNFIA 501
            AW  GDPH  TLDG  + F G  ++LL     G   G  +F +       GS   +   +
Sbjct: 2074 AW--GDPHYVTLDGHRFNFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAVSYTRS 2131

Query: 502  FAAQYRSSSLGPVTVQWLLEPH-DAIRVLLDNQTVTFQPDHEDGGGQETFNATGVLLSRN 560
               Q  + SL  ++ +W  +   D + V L  Q  +    H  G        +G      
Sbjct: 2132 VTLQIYNHSL-TLSARWPRKLQVDGVFVTLPFQLDSLLHAHLSGADVVVTTTSG------ 2184

Query: 561  GSEVSASFDGWATVSVIALSNILHASASLPPEYQNRTEGLLGVWNNNPEDDFRMPNGSTI 620
               +S +FDG + V +            +P  Y     GL G +N +P DD +   G   
Sbjct: 2185 ---LSLAFDGDSFVRL-----------RVPAAYAGSLCGLCGNYNQDPADDLKAVGGK-- 2228

Query: 621  PPGSPEEMLFHFGMTWQINGTGLLGK-RNDQLPSNFTP 657
            P G            WQ+ G    G+  +   PS  TP
Sbjct: 2229 PAG------------WQVGGAQGCGECVSKPCPSPCTP 2254



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 55/218 (25%), Positives = 81/218 (37%), Gaps = 43/218 (19%)

Query: 446  AWMFGDPHITTLDGVSYTFNGLGDFLLV----GAQDGNSSFLLQGRTAQTGSAQATNFIA 501
            AW  GDPH  TLDG  + F G  ++LL     G   G  +F +       GS   +   +
Sbjct: 3275 AW--GDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAVSYTRS 3332

Query: 502  FAAQYRSSSLGPVTVQWLLEPH-DAIRVLLDNQTVTFQPDHEDGGGQETFNATGVLLSRN 560
               Q  + SL  ++ +W  +   D + V L  Q  +    H  G        +G      
Sbjct: 3333 VTLQIYNHSL-TLSARWPRKLQVDGVFVTLPFQLDSLLHAHLSGADVVVTTTSG------ 3385

Query: 561  GSEVSASFDGWATVSVIALSNILHASASLPPEYQNRTEGLLGVWNNNPEDDFRMPNGSTI 620
               +S +FDG + V +            +P  Y     GL G +N +P DD +   G   
Sbjct: 3386 ---LSLAFDGDSFVRL-----------RVPAAYAGSLCGLCGNYNQDPADDLKAVGGK-- 3429

Query: 621  PPGSPEEMLFHFGMTWQINGTGLLGK-RNDQLPSNFTP 657
            P G            WQ+ G    G+  +   PS  TP
Sbjct: 3430 PAG------------WQVGGAQGCGECVSKPCPSPCTP 3455



 Score = 40.8 bits (94), Expect = 0.008
 Identities = 55/218 (25%), Positives = 81/218 (37%), Gaps = 43/218 (19%)

Query: 446  AWMFGDPHITTLDGVSYTFNGLGDFLLV----GAQDGNSSFLLQGRTAQTGSAQATNFIA 501
            AW  GDPH  TLDG  + F G  ++LL     G   G  +F +       GS   +   +
Sbjct: 4476 AW--GDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAVSYTRS 4533

Query: 502  FAAQYRSSSLGPVTVQWLLEPH-DAIRVLLDNQTVTFQPDHEDGGGQETFNATGVLLSRN 560
               Q  + SL  ++ +W  +   D + V L  Q  +    H  G        +G      
Sbjct: 4534 VTLQIYNHSL-TLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSG------ 4586

Query: 561  GSEVSASFDGWATVSVIALSNILHASASLPPEYQNRTEGLLGVWNNNPEDDFRMPNGSTI 620
               +S +FDG + V +            +P  Y     GL G +N +P DD +   G   
Sbjct: 4587 ---LSLAFDGDSFVRL-----------RVPAAYAASLCGLCGNYNQDPADDLKAVGGK-- 4630

Query: 621  PPGSPEEMLFHFGMTWQINGTGLLGK-RNDQLPSNFTP 657
            P G            WQ+ G    G+  +   PS  TP
Sbjct: 4631 PAG------------WQVGGAQGCGECVSKPCPSPCTP 4656



 Score = 37.0 bits (84), Expect = 0.11
 Identities = 20/58 (34%), Positives = 28/58 (48%), Gaps = 6/58 (10%)

Query: 584  HASASLPPEYQNRTEGLLGVWNNNPEDDFRMPNGSTIPPGSPEEMLFHFGMTWQINGT 641
            H   S+P  ++ R  GL G +N N  DDF +PNGS          +  FG  W+  G+
Sbjct: 4969 HLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSA------ASSVETFGAAWRAPGS 5020



 Score = 30.8 bits (68), Expect = 7.9
 Identities = 24/76 (31%), Positives = 26/76 (34%), Gaps = 19/76 (25%)

Query: 821  VAGCKCDGGTF------------------GRYCE-GSEDACEEPCFPSVHCVPGKGCEAC 861
            V GC+CD G                    G Y E GSE   +  C     C PG G   C
Sbjct: 1984 VEGCQCDAGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVC 2043

Query: 862  PPNLTGDGRHCAALGS 877
             P   G G  C  L S
Sbjct: 2044 TPASCGLGEVCGLLPS 2059



 Score = 30.8 bits (68), Expect = 7.9
 Identities = 24/76 (31%), Positives = 26/76 (34%), Gaps = 19/76 (25%)

Query: 821  VAGCKCDGGTF------------------GRYCE-GSEDACEEPCFPSVHCVPGKGCEAC 861
            V GC+CD G                    G Y E GSE   +  C     C PG G   C
Sbjct: 3185 VEGCQCDAGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVC 3244

Query: 862  PPNLTGDGRHCAALGS 877
             P   G G  C  L S
Sbjct: 3245 TPASCGLGEVCGLLPS 3260



 Score = 30.8 bits (68), Expect = 7.9
 Identities = 24/76 (31%), Positives = 26/76 (34%), Gaps = 19/76 (25%)

Query: 821  VAGCKCDGGTF------------------GRYCE-GSEDACEEPCFPSVHCVPGKGCEAC 861
            V GC+CD G                    G Y E GSE   +  C     C PG G   C
Sbjct: 4386 VEGCQCDAGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVC 4445

Query: 862  PPNLTGDGRHCAALGS 877
             P   G G  C  L S
Sbjct: 4446 TPASCGLGEVCGLLPS 4461


>gi|126091152 cubilin [Homo sapiens]
          Length = 3623

 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 37/104 (35%), Positives = 45/104 (43%), Gaps = 20/104 (19%)

Query: 835 CEGSEDACEEPCFPSVHCV--PGKG-CEACPPNLTGDGRHCAALGSSFLCQNQSCPVNYC 891
           CE +   C     P V CV  PG   C+ACPP   GDGR C       L    S     C
Sbjct: 309 CEINNGGCSVA--PPVECVNTPGSSHCQACPPGYQGDGRVCT------LTDICSVSNGGC 360

Query: 892 YNQGHCYISQTLGCQPMCTCPPAFTDSRCFLAGNNFSPTVNLEL 935
           +    C  S TLG  P+CTC P +T       GN + P   ++L
Sbjct: 361 HPDASC--SSTLGSLPLCTCLPGYT-------GNGYGPNGCVQL 395



 Score = 31.6 bits (70), Expect = 4.7
 Identities = 19/60 (31%), Positives = 22/60 (36%), Gaps = 10/60 (16%)

Query: 824 CKCDGGTFGRYC-EGSEDACEEPCFPSVHCVPGKGCEACPPNLTGDGRHCAALGSSFLCQ 882
           CKCD G  G  C E   +    PC     CV G    +C          C  L +  LCQ
Sbjct: 418 CKCDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSC---------ECTRLWTGALCQ 468


>gi|61743978 stabilin 1 precursor [Homo sapiens]
          Length = 2570

 Score = 51.2 bits (121), Expect = 6e-06
 Identities = 43/148 (29%), Positives = 52/148 (35%), Gaps = 27/148 (18%)

Query: 777  EILARSAKIGLA------SALQPRTVVCHCNAESQCLYNQTSRVGNSSLEVAGCKCDGGT 830
            + L RS   G A       A  P    C C    +C       +G S      C CD G 
Sbjct: 1994 QCLCRSGFAGTACELCAPGAFGPHCQACRCTVHGRC----DEGLGGSG----SCFCDEGW 2045

Query: 831  FGRYCEGS---EDACEEPCFPSVHCVPGKGCEACPPNLTGDGRHCAALGSSFLCQNQSCP 887
             G  CE     +  C  PC P   C  G  CE C     GDGR C     + LCQ+    
Sbjct: 2046 TGPRCEVQLELQPVCTPPCAPEAVCRAGNSCE-CSLGYEGDGRVCTV---ADLCQDGH-- 2099

Query: 888  VNYCYNQGHCYISQTLGCQPMCTCPPAF 915
               C    +C     +G    CTC P +
Sbjct: 2100 -GGCSEHANC---SQVGTMVTCTCLPDY 2123



 Score = 38.1 bits (87), Expect = 0.050
 Identities = 41/167 (24%), Positives = 56/167 (33%), Gaps = 54/167 (32%)

Query: 793 PRTVVCHCNAESQCLYNQTSRVGNSSLEVAGCKC-DGGTFGRYCEGSEDACEEP----CF 847
           P  +  HC+  ++C+         S   VA C+C DG     +     + C  P    C 
Sbjct: 824 PTGLAQHCHLHARCV---------SQEGVARCRCLDGFEGDGFSCTPSNPCSHPDRGGCS 874

Query: 848 PSVHCVPGK----GCEACPPNLTGDGRHCAALGSSFLCQNQSC----------------- 886
            +  CVPG      C  C    +GDGR C A+    L     C                 
Sbjct: 875 ENAECVPGSLGTHHC-TCHKGWSGDGRVCVAIDECELDMRGGCHTDALCSYVGPGQSRCT 933

Query: 887 -------------PVNYCY-NQGHCYISQTL----GCQPMCTCPPAF 915
                        P++ C    G C+   T     G Q +CTCPP F
Sbjct: 934 CKLGFAGDGYQCSPIDPCRAGNGGCHGLATCRAVGGGQRVCTCPPGF 980



 Score = 33.1 bits (74), Expect = 1.6
 Identities = 41/132 (31%), Positives = 49/132 (37%), Gaps = 35/132 (26%)

Query: 799 HCNAESQ-CLYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSEDACEEPCFPS-----VHC 852
           HC+ E   C   +  +    S E   C+C  G      +GSE     PC+PS       C
Sbjct: 191 HCDQELPVCQELRCPQNTQCSAEAPSCRCLPGYTQ---QGSECRAPNPCWPSPCSLLAQC 247

Query: 853 -VPGKG---CEACPPNLTGDGRHCAALGSSFLCQNQSCPVNYCY-NQGHCYISQTLGC-- 905
            V  KG   C  CP N  GDG  C              P + C  N G C  + TL C  
Sbjct: 248 SVSPKGQAQCH-CPENYHGDGMVC-------------LPKDPCTDNLGGCPSNSTL-CVY 292

Query: 906 ----QPMCTCPP 913
               Q  CTC P
Sbjct: 293 QKPGQAFCTCRP 304


>gi|239751787 PREDICTED: hypothetical protein XP_002348012 [Homo
            sapiens]
          Length = 3003

 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 50/194 (25%), Positives = 80/194 (41%), Gaps = 35/194 (18%)

Query: 450  GDPHITTLDGVSYTFNGLGDFLLV---GAQDGNSSFLLQGRTAQTGSAQATNFIAFAAQY 506
            GDPH TT DG  + F G   ++L    G + G   F +       G+ + +       Q 
Sbjct: 1256 GDPHYTTFDGRRFDFMGTCVYVLAQTCGTRPGLHRFAVLQENVAWGNGRVSVTRVITVQV 1315

Query: 507  RSSSLGPVTVQWLLEPHDA---IRVLLDNQTVTFQPDHEDGGGQETFNATGVLLSRNGSE 563
             + +L     QW +  +     + V+L N             GQ       +  S++GS+
Sbjct: 1316 ANFTLRLEQRQWKVTVNGVDMKLPVVLAN-------------GQ-------IRASQHGSD 1355

Query: 564  VSASFDGWATVSVIALSNILHASASLPPEYQNRTEGLLGVWNNNPEDDFRMPNGSTIPPG 623
            V    D    V   A   + +   ++P  Y  +  GL G +N +P+DDF+ PNGS    G
Sbjct: 1356 VVIETDFGLRV---AYDLVYYVRVTVPGNYYQQMCGLCGNYNGDPKDDFQKPNGS--QAG 1410

Query: 624  SPEEMLFHFGMTWQ 637
            +  E    FG +W+
Sbjct: 1411 NANE----FGNSWE 1420



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 50/198 (25%), Positives = 74/198 (37%), Gaps = 38/198 (19%)

Query: 450 GDPHITTLDGVSYTFNGLGDFLLV---GAQDGNSSFLLQGRTAQTGSAQATNFIAFAAQY 506
           GDPH TT DG  Y   G   + +V      D   +F ++ +    GS             
Sbjct: 476 GDPHYTTFDGRRYDMMGTCSYTMVELCSEDDTLPAFSVEAKNEHRGSR------------ 523

Query: 507 RSSSLGPVTVQWLLEPHDAIR-----VLLDNQTVTFQPDHEDGGGQETFNATGVLLSRNG 561
           R S +G VTV+         R     VL+DNQ         +G          V  S   
Sbjct: 524 RVSYVGLVTVRAYSHSVSLTRGEVGFVLVDNQRSRLPVSLSEG-------RLRVYQSGPR 576

Query: 562 SEVSASFDGWATVSVIALSNILHASASLPPEYQNRTEGLLGVWNNNPEDDFRMPNGSTIP 621
           + V   F       V+        + SLP  +Q++  GL G +N +P DDF  P+G+  P
Sbjct: 577 AVVELVFG-----LVVTYDWDCQLALSLPARFQDQVCGLCGNYNGDPADDFLTPDGALAP 631

Query: 622 PGSPEEMLFHFGMTWQIN 639
                     F  +W+++
Sbjct: 632 DA------VEFASSWKLD 643



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 48/199 (24%), Positives = 79/199 (39%), Gaps = 27/199 (13%)

Query: 447  WMFGDPHITTLDGVSYTFNGLGDFLLVGAQDGNSSFLLQGRTAQTGSAQATN----FIAF 502
            W++GDPH  + DG  + F G  +++L  A  G      QG T  T + +  N     +++
Sbjct: 1674 WLWGDPHYHSFDGRKFDFQGTCNYVL--ATTGCPGVSTQGLTPFTVTTKNQNRGNPAVSY 1731

Query: 503  AAQYRSSSLGPVTVQWLLEPHDAIRVLLDNQTVTFQPDHEDGGGQETFNATGVLLSRN-G 561
                  ++LG   +    +    +RV ++           DG       A+  LL  + G
Sbjct: 1732 VRVVTVAALG-TNISIHKDEIGKVRVCVNGVLTALPVSVADGRISVAQGASKALLVADFG 1790

Query: 562  SEVSASFDGWATVSVIALSNILHASASLPPEYQNRTEGLLGVWNNNPEDDFRMPNGSTIP 621
             +VS  ++ W                +LP  Y     GL G  + NP +D   PNG T+ 
Sbjct: 1791 LQVSYDWN-W------------RVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNG-TLA 1836

Query: 622  PGSPEEMLFHFGMTWQING 640
            P  P      +G +W+  G
Sbjct: 1837 PSIP-----IWGGSWRAPG 1850



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 45/188 (23%), Positives = 76/188 (40%), Gaps = 22/188 (11%)

Query: 450  GDPHITTLDGVSYTFNGLGDFLLVGAQDGNSSFLLQGRTAQTGSAQATNFIAFAAQYRSS 509
            GDPH  + DG  + F G   +LLVG+  G ++ L   R       + +  +++    R  
Sbjct: 868  GDPHYVSFDGRRFDFMGTCTYLLVGS-CGQNAALPAFRVLVENEHRGSQTVSYTRAVRVE 926

Query: 510  SLGPVTVQWLLEPHDAIRVLLDNQTVTFQPDHEDGGGQETFNATGVLLSRNGSEVSASFD 569
            + G   V+  +      +VL+D+  + + P     G  + F      + R    ++ ++D
Sbjct: 927  ARG---VKVAVRREYPGQVLVDD-VLQYLPFQAADGQVQVFRQGRDAVVRTDFGLTVTYD 982

Query: 570  GWATVSVIALSNILHASASLPPEYQNRTEGLLGVWNNNPEDDFRMPNGSTIPPGSPEEML 629
              A V           +A +P  Y     GL G +N +P DD  +  G     G     L
Sbjct: 983  WNARV-----------TAKVPSSYAEALCGLCGNFNGDPADDLALRGG-----GQAANAL 1026

Query: 630  FHFGMTWQ 637
              FG +WQ
Sbjct: 1027 -AFGNSWQ 1033



 Score = 40.8 bits (94), Expect = 0.008
 Identities = 55/218 (25%), Positives = 81/218 (37%), Gaps = 43/218 (19%)

Query: 446  AWMFGDPHITTLDGVSYTFNGLGDFLLV----GAQDGNSSFLLQGRTAQTGSAQATNFIA 501
            AW  GDPH  TLDG  + F G  ++LL     G   G  +F +       GS   +   +
Sbjct: 2076 AW--GDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAVSYTRS 2133

Query: 502  FAAQYRSSSLGPVTVQWLLEPH-DAIRVLLDNQTVTFQPDHEDGGGQETFNATGVLLSRN 560
               Q  + SL  ++ +W  +   D + V L  Q  +    H  G        +G      
Sbjct: 2134 VTLQIYNHSL-TLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSG------ 2186

Query: 561  GSEVSASFDGWATVSVIALSNILHASASLPPEYQNRTEGLLGVWNNNPEDDFRMPNGSTI 620
               +S +FDG + V +            +P  Y     GL G +N +P DD +   G   
Sbjct: 2187 ---LSLAFDGDSFVRL-----------RVPAAYAASLCGLCGNYNQDPADDLKAVGGK-- 2230

Query: 621  PPGSPEEMLFHFGMTWQINGTGLLGK-RNDQLPSNFTP 657
            P G            WQ+ G    G+  +   PS  TP
Sbjct: 2231 PAG------------WQVGGAQGCGECVSKPCPSPCTP 2256



 Score = 37.0 bits (84), Expect = 0.11
 Identities = 20/58 (34%), Positives = 28/58 (48%), Gaps = 6/58 (10%)

Query: 584  HASASLPPEYQNRTEGLLGVWNNNPEDDFRMPNGSTIPPGSPEEMLFHFGMTWQINGT 641
            H   S+P  ++ R  GL G +N N  DDF +PNGS          +  FG  W+  G+
Sbjct: 2569 HLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSA------ASSVETFGAAWRAPGS 2620



 Score = 30.8 bits (68), Expect = 7.9
 Identities = 24/76 (31%), Positives = 26/76 (34%), Gaps = 19/76 (25%)

Query: 821  VAGCKCDGGTF------------------GRYCE-GSEDACEEPCFPSVHCVPGKGCEAC 861
            V GC+CD G                    G Y E GSE   +  C     C PG G   C
Sbjct: 1986 VEGCQCDAGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVC 2045

Query: 862  PPNLTGDGRHCAALGS 877
             P   G G  C  L S
Sbjct: 2046 TPASCGLGEVCGLLPS 2061


>gi|11321571 slit homolog 3 [Homo sapiens]
          Length = 1523

 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 32/101 (31%), Positives = 37/101 (36%), Gaps = 10/101 (9%)

Query: 824  CKCDGGTFGRYCEGSEDAC-EEPCFPSVHCVP---GKGCEACPPNLTGDGRHCAALGSSF 879
            C+C  G  G+ CE   D C    C     CV    G  C  CP   +G    C       
Sbjct: 1060 CECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTC-TCPQGFSGP--FCEHPPPMV 1116

Query: 880  LCQNQSCPVNYCYNQGHCYISQTLGCQPMCTCPPAFTDSRC 920
            L Q   C    C N   C + Q    +P C CPP F   RC
Sbjct: 1117 LLQTSPCDQYECQNGAQCIVVQQ---EPTCRCPPGFAGPRC 1154



 Score = 44.3 bits (103), Expect = 7e-04
 Identities = 40/161 (24%), Positives = 57/161 (35%), Gaps = 39/161 (24%)

Query: 795  TVVCHCNAESQCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSEDACEE-PCFPSVHCV 853
            TV  +   ++ C +  T  + +S  +   C C  G  G+ CE + D CE+  C  +  CV
Sbjct: 953  TVPINTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCV 1012

Query: 854  PGKG---CEACPPNLTGD------------------GRHCAALGSSFLCQ---------- 882
             G     C  CPPN TG+                     C  L   F C+          
Sbjct: 1013 DGINNYVC-ICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLC 1071

Query: 883  ---NQSCPVNYCYNQGHCYISQTLGCQPMCTCPPAFTDSRC 920
               N  C  + C +   C +    G    CTCP  F+   C
Sbjct: 1072 ETDNDDCVAHKCRHGAQC-VDTINGY--TCTCPQGFSGPFC 1109



 Score = 37.7 bits (86), Expect = 0.065
 Identities = 29/101 (28%), Positives = 38/101 (37%), Gaps = 14/101 (13%)

Query: 824  CKCDGGTFGRYCEGSEDACEEPCFPSVHCVPGKGCEACPPNLTGDGRHCAALGSSFLCQN 883
            C+C  G  G  C+       +PC     C  GK    C    T     CA      LC N
Sbjct: 1353 CECRPGWTGPLCD---QEARDPCLGH-RCHHGK----CVATGTSYMCKCAEGYGGDLCDN 1404

Query: 884  QSCPVNYCY----NQGHCYISQTLGCQPMCTCPPAFTDSRC 920
            ++   N C     + G C+IS     +P C C P F+   C
Sbjct: 1405 KNDSANACSAFKCHHGQCHISDQ--GEPYCLCQPGFSGEHC 1443



 Score = 34.3 bits (77), Expect = 0.72
 Identities = 38/147 (25%), Positives = 52/147 (35%), Gaps = 24/147 (16%)

Query: 796  VVCHCNA--ESQCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSEDAC-EEPCFPSVHC 852
            +V  CNA   S C  N T       +E+  C C     G+ C    + C + PC     C
Sbjct: 913  IVAKCNACLSSPCKNNGTCT--QDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTC 970

Query: 853  ------VPGKGCEACPPNLTGDGRHCAALGSSFLCQNQSCPVNYCYNQGHCYISQTLGCQ 906
                    G  C +CP  L  +G+ C             C  N C N   C         
Sbjct: 971  HLSDSHKDGFSC-SCP--LGFEGQRCEI-------NPDDCEDNDCENNATCVDGIN---N 1017

Query: 907  PMCTCPPAFTDSRCFLAGNNFSPTVNL 933
             +C CPP +T   C    ++  P +NL
Sbjct: 1018 YVCICPPNYTGELCDEVIDHCVPELNL 1044


>gi|134031945 SCO-spondin [Homo sapiens]
          Length = 5147

 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 114/501 (22%), Positives = 166/501 (33%), Gaps = 84/501 (16%)

Query: 450  GDPHITTLDGVSYTFNGLGDFLLVGAQDGNSSFLLQGRTAQTGSAQATNFIAFAAQYRSS 509
            G PH  T DG+++T+ G  ++LLV  ++ +  F +  +    G++  T   A A +    
Sbjct: 1018 GAPHYVTFDGLAFTYPGACEYLLV--REASGLFTVSAQNLPCGASGLTCTKALAVRLEG- 1074

Query: 510  SLGPVTVQWLLEPHDAIRVLLDNQTVTFQPDHEDGGGQETFNATGVLLSRNGSEVSASFD 569
                 TV  +L      R +  N      P    G G     A   LL      ++  +D
Sbjct: 1075 -----TVVHMLRG----RAVTVNGVSVTPPKVYTGPGLSLRRAGLFLLLSTHLGLTLLWD 1125

Query: 570  GWATVSVIALSNILHASASLPPEYQNRTEGLLGVWNNNPEDDFRMPNGSTIP-------- 621
            G   V V            L P+++ R  GL G ++ +  +D R   G   P        
Sbjct: 1126 GGTRVLV-----------QLSPQFRGRVAGLCGDFDGDASNDLRSRQGVLEPTAELAAHS 1174

Query: 622  ----PGSPEEMLFHFGMTWQINGTGLLGKRNDQLPSNFTPVFYSQL--QKNSSWAEHLIS 675
                P  PE        T   +  G    R   L      + ++++  Q++  W  +   
Sbjct: 1175 WRLSPLCPEPGDLPHPCTMNTHRAGWARARCGALLQPLFTLCHAEVPPQQHYEWCLYDAC 1234

Query: 676  NCD--GDSSCIYDTLALRNASIGLHTREVSKNYEQANATLNQYPPSINGGRVIEAYKGQT 733
             CD  GD  C+   +A        H   V    ++  +          GG+V EA     
Sbjct: 1235 GCDSGGDCECLCSAIATYADECARHGHHVRWRSQELCSL------QCEGGQVYEACGPTC 1288

Query: 734  TLIQYTSNAEDANFTLRDSCTDLELFENGTLLWTPKSLEPFTLEILARSAKIGLASALQP 793
                +  + E        +C +      GTLL     LEP +             S LQ 
Sbjct: 1289 PPTCHEQHPEPGWHCQVVACVEGCFCPEGTLLHGGACLEPASCPCEWGRNSFPPGSVLQK 1348

Query: 794  RTVVCHCNAESQCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSEDACEEP---CFPSV 850
                C C  E Q                  C  DGG    +CE    AC E    C  + 
Sbjct: 1349 DCGNCTCQ-EGQW----------------HCGGDGG----HCEELVPACAEGEALCQENG 1387

Query: 851  HCVPGKGCEACPPNLTGDG---RHCAALG---SSFLCQNQSC-PVN-YCYNQGHCYISQT 902
            HCVP  G      +  GDG     CAA G       C +  C P+   C  Q  C     
Sbjct: 1388 HCVP-HGWLCDNQDDCGDGSDEEGCAAPGCGEGQMTCSSGHCLPLALLCDRQDDCGDGTD 1446

Query: 903  LGCQPMCTCPP---AFTDSRC 920
               +P   CP    A  D RC
Sbjct: 1447 ---EPSYPCPQGLLACADGRC 1464



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 53/215 (24%), Positives = 80/215 (37%), Gaps = 46/215 (21%)

Query: 429 QQRRPHVGCATYRPPQPAWMFGDPHITTLDGVSYTFNGLGDFLLVGAQDGNSSFLLQ--G 486
           Q +RP   CA++            H  T DG  Y F G   +LL GA D   +  L    
Sbjct: 187 QHQRPSATCASW---------SGFHYRTFDGRHYHFLGRCTYLLAGAADSTWAVHLTPGD 237

Query: 487 RTAQTGSAQATNFIAFAAQYRSSSLGPVTVQWLLEPHDAIRVLLDNQTVTFQPDHEDGGG 546
           R  Q G  Q    +    +      G V+V+  L P +    LL   ++ +  D      
Sbjct: 238 RCPQPGHCQR---VTMGPEEVLIQAGNVSVKGQLVP-EGQSWLLHGLSLQWLGDW----- 288

Query: 547 QETFNATGVLLSRNGSEVSASFDGWATVSVIALSNILHASASLPPEYQNRTEGLLGVWNN 606
                    L+   G  V    D   ++S+           S+  E   +T+GL G++N 
Sbjct: 289 ---------LVLSGGLGVVVRLDRTGSISI-----------SVDHELWGQTQGLCGLYNG 328

Query: 607 NPEDDFRMPNGSTIPPGSPEEMLFHFGMTWQINGT 641
            PEDDF  P G          +   FG +W++ G+
Sbjct: 329 WPEDDFMEPGGGL------AMLAATFGNSWRLPGS 357



 Score = 39.3 bits (90), Expect = 0.022
 Identities = 51/223 (22%), Positives = 80/223 (35%), Gaps = 34/223 (15%)

Query: 437 CATYRPPQPAWMFGDPHITTLDGVSYTFNGLGDFLLVGAQD---GNSSFLLQGRTAQTGS 493
           CA    P    + GD H  T DG SY+F G         QD   G    LL+      GS
Sbjct: 555 CAQALCPAECAVGGDGHYLTFDGRSYSFWGGQGCRYSLVQDYVKGQLLILLEHGACDAGS 614

Query: 494 AQATNFIAFAAQYRSSSLGPVTVQWLLEPHDAIRVLLDNQTVTFQPDHEDGGGQETFNAT 553
                 ++    +             ++  D+  VL++ Q V       +G      ++ 
Sbjct: 615 CLHAISVSLEDTH-------------IQLRDSGAVLVNGQDVGLPWIGAEGLSVRRASSA 661

Query: 554 GVLLSRNGSEVSASFDGWATVSVIALSNILHASASLPPEYQNRTEGLLGVWNNNPEDDFR 613
            +LL   G++V      W     +A         +L P + ++ +GL G +  N +DDF 
Sbjct: 662 FLLLRWPGAQVL-----WGLSDPVAY-------ITLDPRHAHQVQGLCGTFTQNQQDDF- 708

Query: 614 MPNGSTIPPGSPEEMLFHFGMTWQINGTGLLGKRNDQLPSNFT 656
                  P G  E  +  F   +Q+ G G     +  L S  T
Sbjct: 709 -----LTPAGDVETSIAAFASKFQVAGKGRCPSEDSALLSPCT 746



 Score = 32.7 bits (73), Expect = 2.1
 Identities = 29/94 (30%), Positives = 34/94 (36%), Gaps = 15/94 (15%)

Query: 826  CDGG--TFGRYCEG---SEDACEEPCFPSVHCVPGKGCEACPPNLTGDGRHCAALGSSFL 880
            CDGG  T GR C      +  C  P   +  C        CP N+           S+  
Sbjct: 2846 CDGGIQTRGRSCSSLAPGDTTCPGPHSQTRDCNTQPCTAQCPENML--------FRSAEQ 2897

Query: 881  CQNQSCPV-NYCYNQGHCYISQTLGCQPMCTCPP 913
            C  +  P    C  QG   I  T  C P CTCPP
Sbjct: 2898 CHQEGGPCPRLCLTQGPG-IECTGFCAPGCTCPP 2930



 Score = 32.0 bits (71), Expect = 3.6
 Identities = 25/79 (31%), Positives = 35/79 (44%), Gaps = 16/79 (20%)

Query: 836  EGSEDACEEPCFPSVHCVPGKGCEACPPNLTGDGRHCAAL-GSSFLCQNQSCPVNYCYNQ 894
            +G  D CE P         G+ C+A P  +T    +C A+ G+ +      CP + C + 
Sbjct: 3285 QGLGDYCEGPR------AQGEVCQALPCPVT----NCTAIEGAEYSPCGPPCPRS-CDDL 3333

Query: 895  GHCYISQTLGCQPMCTCPP 913
             HC       CQP C CPP
Sbjct: 3334 VHC----VWRCQPGCYCPP 3348


>gi|110735443 delta-like 1 [Homo sapiens]
          Length = 723

 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 35/130 (26%), Positives = 46/130 (35%), Gaps = 36/130 (27%)

Query: 824 CKCDGGTFGRYCEGSEDACEE-PCFPSVHC---------------VPGKGCEA----CPP 863
           C C  G +G+ CE S   C + PCF    C                 G  CE     C  
Sbjct: 352 CTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSS 411

Query: 864 NLTGDGRHCAALGSSFLCQNQS-------------CPVNYCYNQGHCYISQTLGCQPMCT 910
           +   +G  C  LG ++LC+ Q+             C  + C N G C           CT
Sbjct: 412 SPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVN---DFSCT 468

Query: 911 CPPAFTDSRC 920
           CPP +T   C
Sbjct: 469 CPPGYTGRNC 478



 Score = 44.3 bits (103), Expect = 7e-04
 Identities = 31/102 (30%), Positives = 43/102 (42%), Gaps = 19/102 (18%)

Query: 824 CKCDGGTFGRYCEGSEDAC-EEPCFPSVHCVPGK---GCEACPPNLTGDGRHCAALGSSF 879
           C+C  G  GR+C+ + D C   PC     C  G     C  CPP  T  GR+C+A  S  
Sbjct: 429 CRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSC-TCPPGYT--GRNCSAPVSR- 484

Query: 880 LCQNQSCPVN-YCYNQGHCYISQTLGCQPMCTCPPAFTDSRC 920
            C++  C     C+ +GH Y+         C C   +    C
Sbjct: 485 -CEHAPCHNGATCHERGHRYV---------CECARGYGGPNC 516



 Score = 34.3 bits (77), Expect = 0.72
 Identities = 34/129 (26%), Positives = 44/129 (34%), Gaps = 34/129 (26%)

Query: 824 CKCDGGTFGRYCEGS-------EDACEEPCFPSVHCVPGKGCEACPPNLT--------GD 868
           CKC  G  GRYC+            C++P     +C  G G   C  +L          +
Sbjct: 243 CKCRVGWQGRYCDECIRYPGCLHGTCQQPW--QCNCQEGWGGLFCNQDLNYCTHHKPCKN 300

Query: 869 GRHCAALG-SSFLCQNQ-------------SCPVNYCYNQGHCYISQTLGCQPMCTCPPA 914
           G  C   G  S+ C  +              C  + C N G C     L     CTCPP 
Sbjct: 301 GATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSC---TDLENSYSCTCPPG 357

Query: 915 FTDSRCFLA 923
           F    C L+
Sbjct: 358 FYGKICELS 366


>gi|148833508 notch1 preproprotein [Homo sapiens]
          Length = 2555

 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 37/123 (30%), Positives = 46/123 (37%), Gaps = 22/123 (17%)

Query: 803  ESQCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSEDACE-EPCFPSVHCVPGKGCE-- 859
            ES C    T   G +S     C C  G  G YC+   + C+ +PC     C  G G    
Sbjct: 989  ESSCFNGGTCVDGINSFT---CLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRC 1045

Query: 860  ACPPNLTGDGRHCAALGSSFLCQN--QSCPVNYCYNQGHCYISQTLGCQPMCTCPPAFTD 917
             CP   TG             CQN    C  + C N G C+ + T   Q  C CP  +T 
Sbjct: 1046 TCPQGYTGPN-----------CQNLVHWCDSSPCKNGGKCWQTHT---QYRCECPSGWTG 1091

Query: 918  SRC 920
              C
Sbjct: 1092 LYC 1094



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 39/137 (28%), Positives = 49/137 (35%), Gaps = 25/137 (18%)

Query: 798  CHCNAE----------SQCLYNQTSRVGNSS--LEVAGCKCDGGTFGRYCEGSEDACEEP 845
            CHC A             C  N     G+ +  +  A C C  G  G +CE   + C   
Sbjct: 893  CHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECA-- 950

Query: 846  CFPSVHCVPGKGCEACPPNLTGDGRHCAALGSSFLCQNQS--CPVNYCYNQGHCYISQTL 903
               S  C  G  C  C  + T     C A  S   C+N +  C  + C+N G C      
Sbjct: 951  ---SDPCRNGANCTDCVDSYTCT---CPAGFSGIHCENNTPDCTESSCFNGGTCVDGIN- 1003

Query: 904  GCQPMCTCPPAFTDSRC 920
                 C CPP FT S C
Sbjct: 1004 --SFTCLCPPGFTGSYC 1018



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 36/137 (26%), Positives = 47/137 (34%), Gaps = 43/137 (31%)

Query: 824  CKCDGGTFGRYCEGSEDACE-EPCFPSVHC---VPGKGC---------------EACPPN 864
            C+C  G  G YCE   D C   PC     C   + G  C               + C  +
Sbjct: 1131 CRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSH 1190

Query: 865  LTGDGRHCAALGSSFLC------QNQSCPVNY---------------CYNQGHCYISQTL 903
               +G  C  L +++ C      Q   C +N                C+N G C + Q  
Sbjct: 1191 PCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTC-VDQVG 1249

Query: 904  GCQPMCTCPPAFTDSRC 920
            G    CTCPP F   RC
Sbjct: 1250 GYS--CTCPPGFVGERC 1264



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 37/144 (25%), Positives = 52/144 (36%), Gaps = 21/144 (14%)

Query: 806  CLYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSEDACEEPCFPSVHCVPGKGCEACPPNL 865
            C    T  V +++     CKC  G  G  CE     C      S+ C+ G  C + P + 
Sbjct: 1316 CKNGGTCAVASNTARGFICKCPAGFEGATCENDARTC-----GSLRCLNGGTCISGPRSP 1370

Query: 866  TGDGRHCAALG------SSFLCQNQSCPVNYCYNQGHCYISQTLGCQPM--CTCPPAFTD 917
            T     C  LG        F   +     N CYNQG C   +     P   C CP  F  
Sbjct: 1371 T-----CLCLGPFTGPECQFPASSPCLGGNPCYNQGTC---EPTSESPFYRCLCPAKFNG 1422

Query: 918  SRCFLAGNNFSPTVNLELPLRVIQ 941
              C +   +F      ++P  +I+
Sbjct: 1423 LLCHILDYSFGGGAGRDIPPPLIE 1446



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 37/168 (22%), Positives = 58/168 (34%), Gaps = 47/168 (27%)

Query: 799  HCNAESQCLYNQTSRVGNSSLEVAG---CKCDGGTFGRYCEGSEDACEEP---------C 846
            +C+ E     +   + G + L++     C C  GT G +CE + D C  P         C
Sbjct: 1179 NCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKC 1238

Query: 847  FPSVHCVP---GKGCEACPPNLTGD------------------GRHCAALGSSFLCQNQS 885
            F +  CV    G  C  CPP   G+                   ++C    + F C+ ++
Sbjct: 1239 FNNGTCVDQVGGYSC-TCPPGFVGERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRA 1297

Query: 886  -------------CPVNYCYNQGHCYISQTLGCQPMCTCPPAFTDSRC 920
                         C    C N G C ++       +C CP  F  + C
Sbjct: 1298 GHTGRRCESVINGCKGKPCKNGGTCAVASNTARGFICKCPAGFEGATC 1345



 Score = 39.7 bits (91), Expect = 0.017
 Identities = 31/102 (30%), Positives = 38/102 (37%), Gaps = 18/102 (17%)

Query: 824 CKCDGGTFGRYC-EGSEDACEEPCFPSVHC---VPGKGCEACPPNLTGDGRHCAALGSSF 879
           C C  G  G  C E  +D     CF    C   V    CE CP   TG            
Sbjct: 321 CVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCE-CPHGRTG-----------L 368

Query: 880 LCQ-NQSCPVNYCYNQGHCYISQTLGCQPMCTCPPAFTDSRC 920
           LC  N +C  N C    +C  +   G + +CTCP  +T   C
Sbjct: 369 LCHLNDACISNPCNEGSNCDTNPVNG-KAICTCPSGYTGPAC 409



 Score = 36.6 bits (83), Expect = 0.14
 Identities = 37/161 (22%), Positives = 51/161 (31%), Gaps = 40/161 (24%)

Query: 797 VCHCNAESQCLYNQTSRVGNSSLEVAG---CKCDGGTFGRYCEGSEDACEEPCFPSVHCV 853
           +C    ++ CL N     G   L       C+C  G  G+ C+ ++     PC     C+
Sbjct: 97  LCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCL 156

Query: 854 PGKG---CEACPPNLTGDG---------------RH--------------CAALGSSFLC 881
           P +    C  CPP+  G                 RH              C A  +   C
Sbjct: 157 PFEASYICH-CPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNC 215

Query: 882 QNQ--SCPVNYCYNQGHCYISQTLGCQPMCTCPPAFTDSRC 920
           +     C  + C N G C    T      C C P FT   C
Sbjct: 216 ERPYVPCSPSPCQNGGTC--RPTGDVTHECACLPGFTGQNC 254



 Score = 36.2 bits (82), Expect = 0.19
 Identities = 29/104 (27%), Positives = 36/104 (34%), Gaps = 11/104 (10%)

Query: 818 SLEVAGCKCDGGTFGRYCEGSEDACE-EPCFPSVHCVPGKGCEACPPNLTGDGRHCAALG 876
           SL    C CD G  G  C+ + + CE  PC     C        C       G +C    
Sbjct: 733 SLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQT-- 790

Query: 877 SSFLCQNQSCPVNYCYNQGHCYISQTLGCQPMCTCPPAFTDSRC 920
                    C  N C NQG C I    G +  C C   +T + C
Sbjct: 791 -----NINECASNPCLNQGTC-IDDVAGYK--CNCLLPYTGATC 826



 Score = 35.4 bits (80), Expect = 0.32
 Identities = 39/150 (26%), Positives = 52/150 (34%), Gaps = 22/150 (14%)

Query: 778 ILARSAKIGLASALQPRTVVCHCNAESQCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCEG 837
           +LA    + L  AL  R   C    E+ CL        N +     C C G   G  C+ 
Sbjct: 4   LLAPLLCLALLPALAARGPRCSQPGET-CLNGGKCEAANGT---EACVCGGAFVGPRCQD 59

Query: 838 SEDACEEPC--FPSVHCVPGKGCE--ACPPNLTGDGRHCAALGSSFLC---QNQSCPVNY 890
                  PC    + H V  +G    AC          CA   S  LC    + +C  N 
Sbjct: 60  PNPCLSTPCKNAGTCHVVDRRGVADYAC---------SCALGFSGPLCLTPLDNACLTNP 110

Query: 891 CYNQGHCYISQTLGCQPMCTCPPAFTDSRC 920
           C N G C +      +  C CPP ++   C
Sbjct: 111 CRNGGTCDLLTL--TEYKCRCPPGWSGKSC 138



 Score = 35.0 bits (79), Expect = 0.42
 Identities = 28/120 (23%), Positives = 36/120 (30%), Gaps = 15/120 (12%)

Query: 802 AESQCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSEDAC-EEPCFPSVHCVPGKGCEA 860
           A S CL+N         +    C+C  G  G  C+   D C   PC     C+ G     
Sbjct: 495 ASSPCLHNGRCL---DKINEFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLDGPNTYT 551

Query: 861 CPPNLTGDGRHCAALGSSFLCQNQSCPVNYCYNQGHCYISQTLGCQPMCTCPPAFTDSRC 920
           C       G HC        C    C    C +    +          C C P +T   C
Sbjct: 552 CVCTEGYTGTHCEV--DIDECDPDPCHYGSCKDGVATF---------TCLCRPGYTGHHC 600



 Score = 35.0 bits (79), Expect = 0.42
 Identities = 39/142 (27%), Positives = 48/142 (33%), Gaps = 21/142 (14%)

Query: 799 HCNAESQCLYNQTSRVGNSSLEVAG---CKCDGGTFGRYCEGSEDACEEPCFPSVHC--- 852
           HC        +Q  R G +  +      C C  GT G  CE + D C      S  C   
Sbjct: 599 HCETNINECSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCDSGTCLDK 658

Query: 853 VPGKGCEACPPNLTGDGRHCAALGSSFLCQNQSCPVNYCYNQGHCYISQTLGCQPMCTCP 912
           + G  C AC P  T         GS        C  N C+N G C           C CP
Sbjct: 659 IDGYEC-ACEPGYT---------GSMCNINIDECAGNPCHNGGTCEDGIN---GFTCRCP 705

Query: 913 PAFTDSRCFLAGN--NFSPTVN 932
             + D  C    N  N +P V+
Sbjct: 706 EGYHDPTCLSEVNECNSNPCVH 727



 Score = 33.5 bits (75), Expect = 1.2
 Identities = 45/203 (22%), Positives = 60/203 (29%), Gaps = 26/203 (12%)

Query: 721 NGGRVIEAYKGQTTLIQYTSNAEDANFTLRDSCTDLELFENGTLLWTPKSLEPFTLEILA 780
           NGG     + G   +       ED +  + D C     F   T       +  F  E   
Sbjct: 308 NGGTCHNTHGGYNCVCVNGWTGEDCSENI-DDCASAACFHGATC---HDRVASFYCE--C 361

Query: 781 RSAKIGLASALQPRTVVCHCNAESQCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSED 840
              + GL   L    +   CN  S C    T+ V   ++    C C  G  G  C    D
Sbjct: 362 PHGRTGLLCHLNDACISNPCNEGSNC---DTNPVNGKAI----CTCPSGYTGPACSQDVD 414

Query: 841 ACE---EPCFPSVHCVPGKGCEACPPNLTGDGRHCAALGSSFLCQNQSCPVNYCYNQGHC 897
            C     PC  +  C+   G   C       G  C             C  N C N   C
Sbjct: 415 ECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCE-------IDVNECVSNPCQNDATC 467

Query: 898 YISQTLGCQPMCTCPPAFTDSRC 920
                +G +  C C P +    C
Sbjct: 468 L--DQIG-EFQCICMPGYEGVHC 487



 Score = 32.3 bits (72), Expect = 2.7
 Identities = 22/61 (36%), Positives = 31/61 (50%), Gaps = 9/61 (14%)

Query: 1068 GYKGYDLVYSPQSGFTC---VSPCSRGYCDHGGQCQHLPSGPRCSCVSFSIYTAW-GEHC 1123
            GYK   L+  P +G TC   ++PC+   C +GG+C+        SCV     T W G+ C
Sbjct: 812  GYKCNCLL--PYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCV---CPTGWQGQTC 866

Query: 1124 E 1124
            E
Sbjct: 867  E 867



 Score = 31.6 bits (70), Expect = 4.7
 Identities = 28/103 (27%), Positives = 34/103 (33%), Gaps = 21/103 (20%)

Query: 824 CKCDGGTFGRYCEGSEDAC-EEPCFPSVHCVPGKG---CEACPPNLTGDGRHCAALGSSF 879
           C C  G  G +CE + D C   PC  +  C+       CE CP   TG            
Sbjct: 476 CICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCE-CPTGFTG-----------H 523

Query: 880 LCQN--QSCPVNYCYNQGHCYISQTLGCQPMCTCPPAFTDSRC 920
           LCQ     C    C N   C           C C   +T + C
Sbjct: 524 LCQYDVDECASTPCKNGAKCLDGPN---TYTCVCTEGYTGTHC 563



 Score = 30.8 bits (68), Expect = 7.9
 Identities = 31/105 (29%), Positives = 41/105 (39%), Gaps = 23/105 (21%)

Query: 824 CKCDGGTFGRYCEGSEDACEEPCFPSVHCVPGKGCE--------ACPPNLTGDGRHCAAL 875
           C C  G  G+ CE + D C     P  +C  G  C          CPP  T  G++C   
Sbjct: 243 CACLPGFTGQNCEENIDDC-----PGNNCKNGGACVDGVNTYNCRCPPEWT--GQYC--- 292

Query: 876 GSSFLCQNQSCPVNYCYNQGHCYISQTLGCQPMCTCPPAFTDSRC 920
            +  + + Q  P N C N G C+   T G    C C   +T   C
Sbjct: 293 -TEDVDECQLMP-NACQNGGTCH--NTHGGY-NCVCVNGWTGEDC 332


>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
          Length = 4544

 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 44/169 (26%), Positives = 56/169 (33%), Gaps = 35/169 (20%)

Query: 752  SCTDLELFENGTLLWTPKSLEPFTLEILARSAKIGLASALQPRTVVCHCNAESQCLYNQT 811
            +C + +  +NGT +  P    P                A +P T    C     C  N  
Sbjct: 4170 TCPNGKRLDNGTCVPVPSPTPP--------------PDAPRPGTCNLQCFNGGSCFLNAR 4215

Query: 812  SRVGNSSLEVAGCKCDGGTFGRYCEGSEDACEEPCFPSVHCVPGKGCEACPPNLTGDGRH 871
             +          C+C     G  CE   D C E      HC  G  C A P  +      
Sbjct: 4216 RQ--------PKCRCQPRYTGDKCE--LDQCWE------HCRNGGTCAASPSGMPTC--R 4257

Query: 872  CAALGSSFLCQNQSCPVNYCYNQGHCYISQTLGCQPMCTCPPAFTDSRC 920
            C    +   C  Q C   YC N   C ++Q  G QP C C P F   RC
Sbjct: 4258 CPTGFTGPKCTQQVC-AGYCANNSTCTVNQ--GNQPQCRCLPGFLGDRC 4303



 Score = 34.3 bits (77), Expect = 0.72
 Identities = 35/138 (25%), Positives = 45/138 (32%), Gaps = 20/138 (14%)

Query: 799  HCNAESQCLYNQTSRVGNSSLE-VAGCKCDGGTFGRYCEGSEDACEEPCFPSVHC----- 852
            +C   S C  NQ ++     L    G +C       YCE     C+     S  C     
Sbjct: 4275 YCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGYCENF-GTCQMAADGSRQCRCTAY 4333

Query: 853  VPGKGCE----------ACPPNLTGDGRHCAALGSSFLCQNQSCPVNYCYNQGHCYISQT 902
              G  CE          AC  N       C            +C V +C N G C ++  
Sbjct: 4334 FEGSRCEVNKCSRCLEGACVVNKQSGDVTCNCTDGRVAPSCLTC-VGHCSNGGSCTMNSK 4392

Query: 903  LGCQPMCTCPPAFTDSRC 920
            +   P C CPP  T  RC
Sbjct: 4393 M--MPECQCPPHMTGPRC 4408



 Score = 32.0 bits (71), Expect = 3.6
 Identities = 12/32 (37%), Positives = 18/32 (56%), Gaps = 2/32 (6%)

Query: 891  CYNQGHCYISQTLGCQPMCTCPPAFTDSRCFL 922
            C+N G C+++     QP C C P +T  +C L
Sbjct: 4204 CFNGGSCFLNARR--QPKCRCQPRYTGDKCEL 4233


>gi|153945878 mucin 5, subtype B, tracheobronchial [Homo sapiens]
          Length = 5765

 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 51/178 (28%), Positives = 73/178 (41%), Gaps = 21/178 (11%)

Query: 448  MFGDPHITTLDGVSYTFNGLGDFLL---VGAQDGNSSFLLQGR--TAQTGSAQATNFIAF 502
            M+G  H +T DG SYTF G   ++L   + A+ GN S  L     TA   +A A    A 
Sbjct: 5080 MWGGSHYSTFDGTSYTFRGNCTYVLMREIHARFGNLSLYLDNHYCTASATAAAARCPRAL 5139

Query: 503  AAQYRSSSLGPVTVQWLLEPHDAIRVLLDNQTVTFQPDHEDGGGQETFNATGVLLSRNGS 562
            +  Y+S  +  V    ++   +   +L D   V+             F+  GVL+S  G+
Sbjct: 5140 SIHYKSMDI--VLTVTMVHGKEEGLILFDQIPVS-----------SGFSKNGVLVSVLGT 5186

Query: 563  EVSASFDGWATVSVIALSNILHASASLPPE-YQNRTEGLLGVWNNNPEDDFRMPNGST 619
                       VSV     +    A LP   + N TEG  G   NN  DD    +G+T
Sbjct: 5187 TTMRVDIPALGVSVTFNGQVF--QARLPYSLFHNNTEGQCGTCTNNQRDDCLQRDGTT 5242


>gi|4557679 jagged 1 precursor [Homo sapiens]
          Length = 1218

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 43/140 (30%), Positives = 51/140 (36%), Gaps = 21/140 (15%)

Query: 799 HCNAESQCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSEDAC-EEPCFPSVHCVP--- 854
           +C     CL   T    N+  +   C C  G  G  CE +E AC  +PC     C     
Sbjct: 299 YCGTHQPCLNGGTC--SNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSL 356

Query: 855 GKGCEACPPNLTGDGRHCAALGSSFLCQNQSCPVNYCYNQGHCYISQTLGCQPMCTCPPA 914
           G  CE C P  TG    C+            C  N C + G C   Q L     C CPP 
Sbjct: 357 GFECE-CSPGWTGPT--CST-------NIDDCSPNNCSHGGTC---QDLVNGFKCVCPPQ 403

Query: 915 FTDSRCFLAGN--NFSPTVN 932
           +T   C L  N     P VN
Sbjct: 404 WTGKTCQLDANECEAKPCVN 423



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 32/102 (31%), Positives = 39/102 (38%), Gaps = 16/102 (15%)

Query: 824 CKCDGGTFGRYCEGSEDACEEPCFPSVHC---VPGKGCEACPPNLTGDGRHCAALGSSFL 880
           C C  G  G+ C+ + + C   C     C   V G  C  CPP   GD  HC        
Sbjct: 436 CDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRC-ICPPGYAGD--HCER------ 486

Query: 881 CQNQSCPVNYCYNQGHCYISQTLGCQPMCTCPPAFTDSRCFL 922
                C  N C N GHC   Q    +  C CP  F+ + C L
Sbjct: 487 -DIDECASNPCLNGGHC---QNEINRFQCLCPTGFSGNLCQL 524



 Score = 40.0 bits (92), Expect = 0.013
 Identities = 34/135 (25%), Positives = 46/135 (34%), Gaps = 35/135 (25%)

Query: 824 CKCDGGTFGRYCEGSEDACE-EPCFPSVHCVPGKG--------------CEA----CPPN 864
           C C+ G  G YC  + + CE  PC     C+ G                CE     C  N
Sbjct: 615 CDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQN 674

Query: 865 LTGDGRHCAALGSSFLC-------------QNQSCPVNYCYNQGHCYISQTLGCQPMCTC 911
              +G  C  L + F C             ++  C    C N G CY     G    C C
Sbjct: 675 PCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDE---GDAFKCMC 731

Query: 912 PPAFTDSRCFLAGNN 926
           P  +  + C +A N+
Sbjct: 732 PGGWEGTTCNIARNS 746



 Score = 39.3 bits (90), Expect = 0.022
 Identities = 35/139 (25%), Positives = 47/139 (33%), Gaps = 36/139 (25%)

Query: 824 CKCDGGTFGRYCEGSEDACEE-PCFPSVHCVP--------------GKGCEA----CPPN 864
           C C  G  G YCE + + C + PC     C                GK C +    C   
Sbjct: 653 CICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEA 712

Query: 865 LTGDGRHCAALGSSFLC--------------QNQSCPVNYCYNQGHCYISQTLGCQPMCT 910
              +G  C   G +F C              +N SC  N C+N G C ++   G    C 
Sbjct: 713 TCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVN---GESFTCV 769

Query: 911 CPPAFTDSRCFLAGNNFSP 929
           C   +    C    N+ SP
Sbjct: 770 CKEGWEGPICAQNTNDCSP 788



 Score = 38.1 bits (87), Expect = 0.050
 Identities = 35/130 (26%), Positives = 48/130 (36%), Gaps = 21/130 (16%)

Query: 798 CHCNAESQCLYNQTSRVGNSSL--EVAGCKCDGGTFGRYC-EGSEDACEEPCFPSVHCVP 854
           C+    S CL N     G   +  E   C C  G  G  C + + D    PC+ S  CV 
Sbjct: 740 CNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVD 799

Query: 855 GKG---CEACPPNLTGDGRHCAALGSSFLCQNQSCPVN-YCYNQGHCYISQTLGCQPMCT 910
           G     CE C P   G    C    +   CQ+  C     C ++ + Y          C 
Sbjct: 800 GDNWYRCE-CAPGFAGP--DCRININE--CQSSPCAFGATCVDEINGY---------RCV 845

Query: 911 CPPAFTDSRC 920
           CPP  + ++C
Sbjct: 846 CPPGHSGAKC 855



 Score = 35.8 bits (81), Expect = 0.25
 Identities = 18/44 (40%), Positives = 24/44 (54%), Gaps = 4/44 (9%)

Query: 1071 GYDLVYSPQ-SGFTC---VSPCSRGYCDHGGQCQHLPSGPRCSC 1110
            G++   SP  +G TC   +  CS   C HGG CQ L +G +C C
Sbjct: 357  GFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVC 400



 Score = 32.3 bits (72), Expect = 2.7
 Identities = 34/148 (22%), Positives = 46/148 (31%), Gaps = 30/148 (20%)

Query: 799 HCNAE-SQCLYNQTSRVGNSSLEVAG--CKCDGGTFGRYCEGSEDACE-EPCFPSVHCVP 854
           HC  +  +C  N     G+   E+    C C  G  G  C+   D CE  PC     C  
Sbjct: 483 HCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYN 542

Query: 855 GKGCEACPPNLTGDGRHCAALGSSFLCQNQSCPV----------------------NYCY 892
                 C      +G++C+ L     C+   C V                      N C 
Sbjct: 543 RASDYFCKCPEDYEGKNCSHLKDH--CRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCG 600

Query: 893 NQGHCYISQTLGCQPMCTCPPAFTDSRC 920
             G C      G +  C C   FT + C
Sbjct: 601 PHGKC--KSQSGGKFTCDCNKGFTGTYC 626


>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
          Length = 1200

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 40/144 (27%), Positives = 52/144 (36%), Gaps = 38/144 (26%)

Query: 824 CKCDGGTFGRYC-EGSEDACEEPCFPSVHCV--------------PGKGCEACPPNLTGD 868
           C CD G  G YC E  +D   +PC     C+               G+ C+  P +   D
Sbjct: 584 CICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPD 643

Query: 869 GRH----CAALGSSFLC-------------QNQSCPVNYCYNQGHCYISQTLGCQPMCTC 911
             H    C  L + F C             +   C    C N G CY S   G    C C
Sbjct: 644 PCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDS---GDTFRCAC 700

Query: 912 PPAFTDSRCFLAGNNF---SPTVN 932
           PP +  S C +A N+    +P VN
Sbjct: 701 PPGWKGSTCAVAKNSSCLPNPCVN 724



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 37/130 (28%), Positives = 49/130 (37%), Gaps = 15/130 (11%)

Query: 799 HCNAESQCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSEDACEEPCFPSVHCVPGKGC 858
           +C +   C    T    N+  +   C C  G  GR CE +E AC      S  C  G  C
Sbjct: 310 YCGSHHPCTNGGTCI--NAEPDQYRCTCPDGYSGRNCEKAEHAC-----TSNPCANGGSC 362

Query: 859 EACPPNLTGDGRHCAALGSSFLC--QNQSCPVNYCYNQGHCYISQTLGCQPMCTCPPAFT 916
              P   +G   HC +  S   C      C  N C   G C + Q  G +  C CP  + 
Sbjct: 363 HEVP---SGFECHCPSGWSGPTCALDIDECASNPCAAGGTC-VDQVDGFE--CICPEQWV 416

Query: 917 DSRCFLAGNN 926
            + C L  N+
Sbjct: 417 GATCQLDVND 426



 Score = 39.3 bits (90), Expect = 0.022
 Identities = 36/130 (27%), Positives = 45/130 (34%), Gaps = 36/130 (27%)

Query: 824 CKCDGGTFGRYCEGSEDACEE-------PCFPS-----VHCVPG-KGC-------EACPP 863
           C CD G  G+ C   E  C+         C+ S       C PG KG         +C P
Sbjct: 660 CACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLP 719

Query: 864 NLTGDGRHCAALGSSFLC------QNQSCPVNY-------CYNQGHCYISQTLGCQPMCT 910
           N   +G  C   G+SF C      + ++C  N        CYN G C           C 
Sbjct: 720 NPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWF---RCE 776

Query: 911 CPPAFTDSRC 920
           C P F    C
Sbjct: 777 CAPGFAGPDC 786



 Score = 36.6 bits (83), Expect = 0.14
 Identities = 31/99 (31%), Positives = 34/99 (34%), Gaps = 13/99 (13%)

Query: 824 CKCDGGTFGRYCEGSEDACEEPCFPSVHCVPGKGCEACPPNLTGDGRHCAALGSSFLCQ- 882
           C C  G  GR+CE   D C      S  C  G  CE       G   HC    S  LC+ 
Sbjct: 446 CVCPRGFGGRHCELERDEC-----ASSPCHSGGLCEDL---ADGFHCHCPQGFSGPLCEV 497

Query: 883 -NQSCPVNYCYNQGHCYISQTLGCQPMCTCPPAFTDSRC 920
               C  + C N   CY    L     C CP  F    C
Sbjct: 498 DVDLCEPSPCRNGARCY---NLEGDYYCACPDDFGGKNC 533



 Score = 35.8 bits (81), Expect = 0.25
 Identities = 27/101 (26%), Positives = 36/101 (35%), Gaps = 22/101 (21%)

Query: 824 CKCDGGTFGRYCEGSEDACEEPCFPSVHCVPGKGCEACPPNLTGDGRHCAALGSSFLCQN 883
           C+C  G  GR+C        + C P   CV G   E    N       C       LC  
Sbjct: 262 CRCSYGWQGRFC--------DECVPYPGCVHGSCVEPWQCN-------CETNWGGLLCDK 306

Query: 884 QSCPVNYCYNQGHCYISQT-LGCQP---MCTCPPAFTDSRC 920
               +NYC +   C    T +  +P    CTCP  ++   C
Sbjct: 307 D---LNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNC 344



 Score = 35.8 bits (81), Expect = 0.25
 Identities = 23/62 (37%), Positives = 30/62 (48%), Gaps = 9/62 (14%)

Query: 1067 DGYKGYDLVYSPQ-SGFTC---VSPCSRGYCDHGGQCQHLPSGPRCSCVSFSIYTAWGEH 1122
            D   G++ +   Q  G TC   V+ C RG C HGG C+ L +G +C C         G H
Sbjct: 402  DQVDGFECICPEQWVGATCQLDVNDC-RGQCQHGGTCKDLVNGYQCVCPR----GFGGRH 456

Query: 1123 CE 1124
            CE
Sbjct: 457  CE 458



 Score = 33.9 bits (76), Expect = 0.94
 Identities = 36/129 (27%), Positives = 45/129 (34%), Gaps = 19/129 (14%)

Query: 798 CHCNAESQCLYNQTSRVGN--SSLEVAGCKCDGGTFGRYCEGSEDACEE-PCFPSVHCVP 854
           C     S CL N     G    S     C C  G  GR C  + + C   PC+    CV 
Sbjct: 709 CAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVD 768

Query: 855 GKG---CEACPPNLTGDGRHCAALGSSFLCQNQSCPVNYCYNQGHCYISQTLGCQPMCTC 911
           G     CE C P   G            + + QS P  Y    G   + +  G +  C+C
Sbjct: 769 GVNWFRCE-CAPGFAGPDCRIN------IDECQSSPCAY----GATCVDEINGYR--CSC 815

Query: 912 PPAFTDSRC 920
           PP     RC
Sbjct: 816 PPGRAGPRC 824



 Score = 32.7 bits (73), Expect = 2.1
 Identities = 17/52 (32%), Positives = 24/52 (46%), Gaps = 10/52 (19%)

Query: 1064 FRC---DGYKGYDLVYSPQSGFTCVSPCSRGYCDHGGQCQHLPSGPRCSCVS 1112
            +RC   DGY G +   +  +       C+   C +GG C  +PSG  C C S
Sbjct: 331  YRCTCPDGYSGRNCEKAEHA-------CTSNPCANGGSCHEVPSGFECHCPS 375


>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
          Length = 1238

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 40/144 (27%), Positives = 52/144 (36%), Gaps = 38/144 (26%)

Query: 824 CKCDGGTFGRYC-EGSEDACEEPCFPSVHCV--------------PGKGCEACPPNLTGD 868
           C CD G  G YC E  +D   +PC     C+               G+ C+  P +   D
Sbjct: 622 CICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPD 681

Query: 869 GRH----CAALGSSFLC-------------QNQSCPVNYCYNQGHCYISQTLGCQPMCTC 911
             H    C  L + F C             +   C    C N G CY S   G    C C
Sbjct: 682 PCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDS---GDTFRCAC 738

Query: 912 PPAFTDSRCFLAGNNF---SPTVN 932
           PP +  S C +A N+    +P VN
Sbjct: 739 PPGWKGSTCAVAKNSSCLPNPCVN 762



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 37/129 (28%), Positives = 48/129 (37%), Gaps = 15/129 (11%)

Query: 799 HCNAESQCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSEDACEEPCFPSVHCVPGKGC 858
           +C +   C    T    N+  +   C C  G  GR CE +E AC      S  C  G  C
Sbjct: 310 YCGSHHPCTNGGTCI--NAEPDQYRCTCPDGYSGRNCEKAEHAC-----TSNPCANGGSC 362

Query: 859 EACPPNLTGDGRHCAALGSSFLC--QNQSCPVNYCYNQGHCYISQTLGCQPMCTCPPAFT 916
              P   +G   HC +  S   C      C  N C   G C + Q  G +  C CP  + 
Sbjct: 363 HEVP---SGFECHCPSGWSGPTCALDIDECASNPCAAGGTC-VDQVDGFE--CICPEQWV 416

Query: 917 DSRCFLAGN 925
            + C L  N
Sbjct: 417 GATCQLDAN 425



 Score = 39.3 bits (90), Expect = 0.022
 Identities = 36/130 (27%), Positives = 45/130 (34%), Gaps = 36/130 (27%)

Query: 824 CKCDGGTFGRYCEGSEDACEE-------PCFPS-----VHCVPG-KGC-------EACPP 863
           C CD G  G+ C   E  C+         C+ S       C PG KG         +C P
Sbjct: 698 CACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLP 757

Query: 864 NLTGDGRHCAALGSSFLC------QNQSCPVNY-------CYNQGHCYISQTLGCQPMCT 910
           N   +G  C   G+SF C      + ++C  N        CYN G C           C 
Sbjct: 758 NPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWF---RCE 814

Query: 911 CPPAFTDSRC 920
           C P F    C
Sbjct: 815 CAPGFAGPDC 824



 Score = 38.1 bits (87), Expect = 0.050
 Identities = 37/128 (28%), Positives = 44/128 (34%), Gaps = 19/128 (14%)

Query: 798 CHCNAES---QCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSEDACEEPCFPSVHCVP 854
           CH N      QC +  T +   +  +   C C  G  GR+CE   D C      S  C  
Sbjct: 458 CHINVNDCRGQCQHGGTCKDLVNGYQ---CVCPRGFGGRHCELERDEC-----ASSPCHS 509

Query: 855 GKGCEACPPNLTGDGRHCAALGSSFLCQ--NQSCPVNYCYNQGHCYISQTLGCQPMCTCP 912
           G  CE       G   HC    S  LC+     C  + C N   CY    L     C CP
Sbjct: 510 GGLCEDL---ADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCY---NLEGDYYCACP 563

Query: 913 PAFTDSRC 920
             F    C
Sbjct: 564 DDFGGKNC 571



 Score = 35.8 bits (81), Expect = 0.25
 Identities = 27/101 (26%), Positives = 36/101 (35%), Gaps = 22/101 (21%)

Query: 824 CKCDGGTFGRYCEGSEDACEEPCFPSVHCVPGKGCEACPPNLTGDGRHCAALGSSFLCQN 883
           C+C  G  GR+C        + C P   CV G   E    N       C       LC  
Sbjct: 262 CRCSYGWQGRFC--------DECVPYPGCVHGSCVEPWQCN-------CETNWGGLLCDK 306

Query: 884 QSCPVNYCYNQGHCYISQT-LGCQP---MCTCPPAFTDSRC 920
               +NYC +   C    T +  +P    CTCP  ++   C
Sbjct: 307 D---LNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNC 344



 Score = 35.4 bits (80), Expect = 0.32
 Identities = 24/76 (31%), Positives = 32/76 (42%), Gaps = 15/76 (19%)

Query: 1052 VTALNVSTLKAYFRCDGYKGYDLVYSPQSGFTC---VSPCSRGYCDHGGQCQHLPSGPRC 1108
            + A +   L   + CD   G+        G  C   V+ C RG C HGG C+ L +G +C
Sbjct: 433  LNAFSCKNLIGGYYCDCIPGW-------KGINCHINVNDC-RGQCQHGGTCKDLVNGYQC 484

Query: 1109 SCVSFSIYTAWGEHCE 1124
             C         G HCE
Sbjct: 485  VCPR----GFGGRHCE 496



 Score = 33.9 bits (76), Expect = 0.94
 Identities = 36/129 (27%), Positives = 45/129 (34%), Gaps = 19/129 (14%)

Query: 798 CHCNAESQCLYNQTSRVGN--SSLEVAGCKCDGGTFGRYCEGSEDACEE-PCFPSVHCVP 854
           C     S CL N     G    S     C C  G  GR C  + + C   PC+    CV 
Sbjct: 747 CAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVD 806

Query: 855 GKG---CEACPPNLTGDGRHCAALGSSFLCQNQSCPVNYCYNQGHCYISQTLGCQPMCTC 911
           G     CE C P   G            + + QS P  Y    G   + +  G +  C+C
Sbjct: 807 GVNWFRCE-CAPGFAGPDCRIN------IDECQSSPCAY----GATCVDEINGYR--CSC 853

Query: 912 PPAFTDSRC 920
           PP     RC
Sbjct: 854 PPGRAGPRC 862



 Score = 32.7 bits (73), Expect = 2.1
 Identities = 17/52 (32%), Positives = 24/52 (46%), Gaps = 10/52 (19%)

Query: 1064 FRC---DGYKGYDLVYSPQSGFTCVSPCSRGYCDHGGQCQHLPSGPRCSCVS 1112
            +RC   DGY G +   +  +       C+   C +GG C  +PSG  C C S
Sbjct: 331  YRCTCPDGYSGRNCEKAEHA-------CTSNPCANGGSCHEVPSGFECHCPS 375


>gi|209571519 cysteine rich BMP regulator 2 isoform 1 [Homo sapiens]
          Length = 1503

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 55/199 (27%), Positives = 85/199 (42%), Gaps = 31/199 (15%)

Query: 443  PQPA--WMFGDPHITTLDGVSYTFNGLGDFLLVGAQDGNSSFLLQGRTAQTGSAQATNFI 500
            P+PA    FGDPH  T DG    F G   ++L  A+D +S          T   +  + +
Sbjct: 1145 PRPASCMAFGDPHYRTFDGRLLHFQGSCSYVL--AKDCHSGDF---SVHVTNDDRGRSGV 1199

Query: 501  AFAAQYRSSSLGPVTVQWLLEPHDAIRVLLDNQTVTFQPDHEDGGGQETFNATGVLLSRN 560
            A+  +  +  LG + V+ L +      V +D   V      E     E    T +L ++ 
Sbjct: 1200 AWTQEV-AVLLGDMAVRLLQDG----AVTVDGHPVALPFLQEPLLYVELRGHTVILHAQP 1254

Query: 561  GSEVSASFDGWATVSVIALSNILHASASLPPEYQNRTEGLLGVWNNNPEDDFRMPNGSTI 620
            G +V   +DG + V V           S+P  YQ RT GL G +N   +DD + P G  +
Sbjct: 1255 GLQVL--WDGQSQVEV-----------SVPGSYQGRTCGLCGNFNGFAQDDLQGPEGLLL 1301

Query: 621  PPGSPEEMLFHFGMTWQIN 639
            P  +       FG +WQ++
Sbjct: 1302 PSEAA------FGNSWQVS 1314



 Score = 35.8 bits (81), Expect = 0.25
 Identities = 31/98 (31%), Positives = 35/98 (35%), Gaps = 18/98 (18%)

Query: 824 CKCDGG--TFGRY-CEGSEDACEEPCFPSVHCVPG-KGC----------EACPPNLTGDG 869
           C C GG  T GR  CE     C  P  PS HC P  +GC          E  P  L    
Sbjct: 742 CTCLGGFVTCGRRPCE--PPGCSHPLIPSGHCCPTCQGCRYHGVTTASGETLPDPLDPTC 799

Query: 870 RHCAALGSSFLCQNQSCPVNYC--YNQGHCYISQTLGC 905
             C     S  CQ + CP   C   + G C+      C
Sbjct: 800 SLCTCQEGSMRCQKKPCPPALCPHPSPGPCFCPVCHSC 837


>gi|161019170 mucin 5AC [Homo sapiens]
          Length = 6207

 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 50/178 (28%), Positives = 70/178 (39%), Gaps = 19/178 (10%)

Query: 448  MFGDPHITTLDGVSYTFNGLGDFLL---VGAQDGNSSFLLQGR--TAQTGSAQATNFIAF 502
            M+G  H +T DG SYTF G   ++L   + A+ GN S  L     TA   +A A      
Sbjct: 5412 MWGGSHYSTFDGTSYTFRGNCTYVLMREIHARFGNLSLYLDNHYCTASATAAAAAARCPR 5471

Query: 503  AAQYRSSSLGPVTVQWLLEPHDAIRVLLDNQTVTFQPDHEDGGGQETFNATGVLLSRNGS 562
            A      S+  V    ++   +   +L D   V+             F+  GVL+S  G+
Sbjct: 5472 ALSIHYKSMDIVLTVTMVHGKEEGLILFDQIPVS-----------SGFSKNGVLVSVLGT 5520

Query: 563  EVSASFDGWATVSVIALSNILHASASLPPE-YQNRTEGLLGVWNNNPEDDFRMPNGST 619
                       VSV     +    A LP   + N TEG  G   NN  DD    +G+T
Sbjct: 5521 TTMRVDIPALGVSVTFNGQVF--QARLPYSLFHNNTEGQCGTCTNNQRDDCLQRDGTT 5576


>gi|239757286 PREDICTED: similar to Fc fragment of IgG binding
           protein [Homo sapiens]
          Length = 1472

 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 50/198 (25%), Positives = 74/198 (37%), Gaps = 38/198 (19%)

Query: 450 GDPHITTLDGVSYTFNGLGDFLLV---GAQDGNSSFLLQGRTAQTGSAQATNFIAFAAQY 506
           GDPH TT DG  Y   G   + +V      D   +F ++ +    GS             
Sbjct: 537 GDPHYTTFDGRRYDMMGTCSYTMVELCSEDDTLPAFSVEAKNEHRGSR------------ 584

Query: 507 RSSSLGPVTVQWLLEPHDAIR-----VLLDNQTVTFQPDHEDGGGQETFNATGVLLSRNG 561
           R S +G VTV+         R     VL+DNQ         +G          V  S   
Sbjct: 585 RVSYVGLVTVRAYSHSVSLTRGEVGFVLVDNQRSRLPVSLSEG-------RLRVYQSGPR 637

Query: 562 SEVSASFDGWATVSVIALSNILHASASLPPEYQNRTEGLLGVWNNNPEDDFRMPNGSTIP 621
           + V   F       V+        + SLP  +Q++  GL G +N +P DDF  P+G+  P
Sbjct: 638 AVVELVFG-----LVVTYDWDCQLALSLPARFQDQVCGLCGNYNGDPADDFLTPDGALAP 692

Query: 622 PGSPEEMLFHFGMTWQIN 639
                     F  +W+++
Sbjct: 693 DA------VEFASSWKLD 704



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 45/188 (23%), Positives = 76/188 (40%), Gaps = 22/188 (11%)

Query: 450  GDPHITTLDGVSYTFNGLGDFLLVGAQDGNSSFLLQGRTAQTGSAQATNFIAFAAQYRSS 509
            GDPH  + DG  + F G   +LLVG+  G ++ L   R       + +  +++    R  
Sbjct: 929  GDPHYVSFDGRRFDFMGTCTYLLVGS-CGQNAALPAFRVLVENEHRGSQTVSYTRAVRVE 987

Query: 510  SLGPVTVQWLLEPHDAIRVLLDNQTVTFQPDHEDGGGQETFNATGVLLSRNGSEVSASFD 569
            + G   V+  +      +VL+D+  + + P     G  + F      + R    ++ ++D
Sbjct: 988  ARG---VKVAVRREYPGQVLVDD-VLQYLPFQAADGQVQVFRQGRDAVVRTDFGLTVTYD 1043

Query: 570  GWATVSVIALSNILHASASLPPEYQNRTEGLLGVWNNNPEDDFRMPNGSTIPPGSPEEML 629
              A V           +A +P  Y     GL G +N +P DD  +  G     G     L
Sbjct: 1044 WNARV-----------TAKVPSSYAEALCGLCGNFNGDPADDLALRGG-----GQAANAL 1087

Query: 630  FHFGMTWQ 637
              FG +WQ
Sbjct: 1088 -AFGNSWQ 1094


>gi|62988324 tenascin N [Homo sapiens]
          Length = 1299

 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 41/144 (28%), Positives = 49/144 (34%), Gaps = 33/144 (22%)

Query: 800 CNAESQC-----LYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSEDACEEPCFPSVHCVP 854
           C+A+  C     L    S  G  SLE   C C+ G  G  CE    AC   C     CV 
Sbjct: 126 CSAQRCCQGVTDLSRHCSGHGTFSLETCSCHCEEGREGPACE--RLACPGACSGHGRCVD 183

Query: 855 GK------------GCEACPPNLTGDGR------HCAALGSSFLCQNQSCPVNYCYNQGH 896
           G+            G  ACP N +G G        C     S  C  + CP + C   G 
Sbjct: 184 GRCLCHEPYVGADCGYPACPENCSGHGECVRGVCQCHEDFMSEDCSEKRCPGD-CSGHGF 242

Query: 897 CYISQTLGCQPMCTCPPAFTDSRC 920
           C   +       C C   FT   C
Sbjct: 243 CDTGE-------CYCEEGFTGLDC 259


>gi|89191868 von Willebrand factor preproprotein [Homo sapiens]
          Length = 2813

 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 54/206 (26%), Positives = 82/206 (39%), Gaps = 29/206 (14%)

Query: 437 CATYRPPQPAWMFGDPHITTLDGVSYTFNGLGDFLLV-GAQDGNSSFLLQG-RTAQTGSA 494
           C+    P    + G  H  + D   +TF+G+  +LL    QD + S +++  + A    A
Sbjct: 379 CSNEECPGECLVTGQSHFKSFDNRYFTFSGICQYLLARDCQDHSFSIVIETVQCADDRDA 438

Query: 495 QATNFIAFAAQYRSSSLGPVTVQWLLEPHDAIRVLLDNQTVTFQPDHEDGGGQETFNATG 554
             T  +        +SL  +        H A  V +D Q V       D   Q T  A+ 
Sbjct: 439 VCTRSVTVRLPGLHNSLVKLK-------HGA-GVAMDGQDVQLPLLKGDLRIQHTVTAS- 489

Query: 555 VLLSRNGSEVSASFDGWATVSVIALSNILHASASLPPEYQNRTEGLLGVWNNNPEDDFRM 614
           V LS  G ++   +DG   + V            L P Y  +T GL G +N N  DDF  
Sbjct: 490 VRLSY-GEDLQMDWDGRGRLLV-----------KLSPVYAGKTCGLCGNYNGNQGDDFLT 537

Query: 615 PNGSTIPPGSPEEMLFHFGMTWQING 640
           P+G        E  +  FG  W+++G
Sbjct: 538 PSGLA------EPRVEDFGNAWKLHG 557


>gi|239757284 PREDICTED: similar to Fc fragment of IgG binding
           protein [Homo sapiens]
          Length = 593

 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 49/196 (25%), Positives = 78/196 (39%), Gaps = 23/196 (11%)

Query: 447 WMFGDPHITTLDGVSYTFNGLGDFLLVGAQDGNSSFLLQGRTAQTGSAQATNFIAFAAQY 506
           W++GDPH  + DG  + F G  +++L  A  G      QG T  T + +  N    A  Y
Sbjct: 373 WLWGDPHYHSFDGRKFDFQGTCNYVL--ATTGCPGVSTQGLTPFTVTTKNQNRGNPAVSY 430

Query: 507 -RSSSLGPVTVQWLLEPHDAIRVLLDNQTVTFQPDHEDGGGQETFNATGVLLSRN-GSEV 564
            R  ++  +     +   +  +V ++           DG    T  A+  LL  + G +V
Sbjct: 431 VRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVTQGASKALLVADFGLQV 490

Query: 565 SASFDGWATVSVIALSNILHASASLPPEYQNRTEGLLGVWNNNPEDDFRMPNGSTIPPGS 624
           S  ++ W                +LP  Y     GL G  + NP +D   PNG T+ P  
Sbjct: 491 SYDWN-W------------RVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNG-TLAPSI 536

Query: 625 PEEMLFHFGMTWQING 640
           P      +G +W+  G
Sbjct: 537 P-----IWGGSWRAPG 547



 Score = 40.4 bits (93), Expect = 0.010
 Identities = 26/80 (32%), Positives = 41/80 (51%), Gaps = 9/80 (11%)

Query: 558 SRNGSEVSASFDGWATVSVIALSNILHASASLPPEYQNRTEGLLGVWNNNPEDDFRMPNG 617
           S++GS+V    D    V   A   + +   ++P  Y  +  GL G +N +P+DDF+ PNG
Sbjct: 15  SQHGSDVVIETDFGLRV---AYDLVYYVRVTVPGNYYQQMCGLCGNYNGDPKDDFQKPNG 71

Query: 618 STIPPGSPEEMLFHFGMTWQ 637
           S    G+  E    FG +W+
Sbjct: 72  S--QAGNANE----FGNSWE 85


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.136    0.445 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,913,748
Number of Sequences: 37866
Number of extensions: 2699742
Number of successful extensions: 8092
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 54
Number of HSP's successfully gapped in prelim test: 189
Number of HSP's that attempted gapping in prelim test: 6453
Number of HSP's gapped (non-prelim): 1707
length of query: 1176
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1063
effective length of database: 13,968,660
effective search space: 14848685580
effective search space used: 14848685580
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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