Guide to the Human Genome
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Search of human proteins with 11225258

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|11225258 myelin associated glycoprotein isoform a precursor
[Homo sapiens]
         (626 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|11225258 myelin associated glycoprotein isoform a precursor [...  1270   0.0  
gi|18104957 myelin associated glycoprotein isoform b precursor [...  1167   0.0  
gi|31377639 sialic acid binding Ig-like lectin 10 [Homo sapiens]      190   3e-48
gi|205830470 sialic acid binding Ig-like lectin 11 isoform 1 [Ho...   171   2e-42
gi|13489095 sialoadhesin precursor [Homo sapiens]                     143   4e-34
gi|205830473 sialic acid binding Ig-like lectin 11 isoform 2 [Ho...   139   1e-32
gi|7657570 sialic acid binding Ig-like lectin 7 isoform 1 [Homo ...   128   1e-29
gi|94538343 sialic acid binding Ig-like lectin 8 [Homo sapiens]       127   4e-29
gi|4502659 sialic acid binding Ig-like lectin 5 [Homo sapiens]        121   2e-27
gi|23943856 sialic acid binding Ig-like lectin 9 [Homo sapiens]       119   8e-27
gi|16506826 sialic acid binding immunoglobulin-like lectin-like ...   118   1e-26
gi|16506828 sialic acid binding immunoglobulin-like lectin-like ...   118   1e-26
gi|193794821 sialic acid binding Ig-like lectin 6 isoform 1 prec...   115   9e-26
gi|157168355 CD22 molecule [Homo sapiens]                             115   1e-25
gi|193794819 sialic acid binding Ig-like lectin 6 isoform 2 prec...   114   3e-25
gi|148762980 sialic acid binding Ig-like lectin 14 [Homo sapiens]     110   5e-24
gi|193794817 sialic acid binding Ig-like lectin 6 isoform 3 prec...   109   9e-24
gi|118572606 hemicentin 1 [Homo sapiens]                               99   1e-20
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]                    96   1e-19
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]                    96   1e-19
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]                    96   1e-19
gi|130979981 CD33 antigen isoform 1 precursor [Homo sapiens]           94   5e-19
gi|109150416 peroxidasin [Homo sapiens]                                90   5e-18
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]         88   3e-17
gi|4507875 vascular cell adhesion molecule 1 isoform a precursor...    87   6e-17
gi|18201909 vascular cell adhesion molecule 1 isoform b precurso...    86   1e-16
gi|145275174 kin of IRRE-like 2 isoform c [Homo sapiens]               85   2e-16
gi|145275172 kin of IRRE-like 2 isoform b [Homo sapiens]               85   2e-16
gi|145275170 kin of IRRE-like 2 isoform a [Homo sapiens]               85   2e-16
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo...    84   5e-16

>gi|11225258 myelin associated glycoprotein isoform a precursor
           [Homo sapiens]
          Length = 626

 Score = 1270 bits (3287), Expect = 0.0
 Identities = 626/626 (100%), Positives = 626/626 (100%)

Query: 1   MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWY 60
           MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWY
Sbjct: 1   MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWY 60

Query: 61  FNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGD 120
           FNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGD
Sbjct: 61  FNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGD 120

Query: 121 LGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGL 180
           LGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGL
Sbjct: 121 LGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGL 180

Query: 181 GEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP 240
           GEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP
Sbjct: 181 GEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP 240

Query: 241 VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAED 300
           VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAED
Sbjct: 241 VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAED 300

Query: 301 GVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIF 360
           GVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIF
Sbjct: 301 GVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIF 360

Query: 361 KEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESH 420
           KEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESH
Sbjct: 361 KEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESH 420

Query: 421 CAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQA 480
           CAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQA
Sbjct: 421 CAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQA 480

Query: 481 QAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKK 540
           QAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKK
Sbjct: 481 QAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKK 540

Query: 541 NVTESPSFSAGDNPPVLFSSDFRISGAPEKYESERRLGSERRLLGLRGEPPELDLSYSHS 600
           NVTESPSFSAGDNPPVLFSSDFRISGAPEKYESERRLGSERRLLGLRGEPPELDLSYSHS
Sbjct: 541 NVTESPSFSAGDNPPVLFSSDFRISGAPEKYESERRLGSERRLLGLRGEPPELDLSYSHS 600

Query: 601 DLGKRPTKDSYTLTEELAEYAEIRVK 626
           DLGKRPTKDSYTLTEELAEYAEIRVK
Sbjct: 601 DLGKRPTKDSYTLTEELAEYAEIRVK 626


>gi|18104957 myelin associated glycoprotein isoform b precursor
           [Homo sapiens]
          Length = 582

 Score = 1167 bits (3019), Expect = 0.0
 Identities = 573/574 (99%), Positives = 574/574 (100%)

Query: 1   MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWY 60
           MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWY
Sbjct: 1   MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWY 60

Query: 61  FNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGD 120
           FNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGD
Sbjct: 61  FNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGD 120

Query: 121 LGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGL 180
           LGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGL
Sbjct: 121 LGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGL 180

Query: 181 GEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP 240
           GEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP
Sbjct: 181 GEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP 240

Query: 241 VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAED 300
           VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAED
Sbjct: 241 VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAED 300

Query: 301 GVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIF 360
           GVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIF
Sbjct: 301 GVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIF 360

Query: 361 KEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESH 420
           KEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESH
Sbjct: 361 KEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESH 420

Query: 421 CAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQA 480
           CAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQA
Sbjct: 421 CAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQA 480

Query: 481 QAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKK 540
           QAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKK
Sbjct: 481 QAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKK 540

Query: 541 NVTESPSFSAGDNPPVLFSSDFRISGAPEKYESE 574
           NVTESPSFSAGDNPPVLFSSDFRISGAPEKYES+
Sbjct: 541 NVTESPSFSAGDNPPVLFSSDFRISGAPEKYESK 574


>gi|31377639 sialic acid binding Ig-like lectin 10 [Homo sapiens]
          Length = 697

 Score =  190 bits (483), Expect = 3e-48
 Identities = 164/587 (27%), Positives = 256/587 (43%), Gaps = 63/587 (10%)

Query: 15  SASRGGHWGAWMPSSISAFEGTCVSIPCRFDFP--DELRPAVVHGVWYFNSPYPKNYPPV 72
           S +  G +   +  S+   EG C+S+PC F +P  D       +G W+          PV
Sbjct: 14  SQAMDGRFWIRVQESVMVPEGLCISVPCSFSYPRQDWTGSTPAYGYWFKAVTETTKGAPV 73

Query: 73  VFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYNQYTFSEH 132
               +++ V  S +GR +L GD    NC+L++ +   +   +Y+FR + G Y +Y F   
Sbjct: 74  ATNHQSREVEMSTRGRFQLTGDPAKGNCSLVIRDAQMQDESQYFFRVERGSYVRYNFMND 133

Query: 133 ----SVLDIVNTPNIVVPPEVVAGTEVEVSCMVP---DNCPELRPELSWLGHEGLGEPAV 185
                V  +   P++ +P  +  G  V V C+     + CP   P  SW G       A 
Sbjct: 134 GFFLKVTALTQKPDVYIPETLEPGQPVTVICVFNWAFEECPP--PSFSWTG-------AA 184

Query: 186 LGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEM 245
           L   +  + T    S+L F P  + +   L C   F    +  +    + V Y P  + +
Sbjct: 185 LSS-QGTKPTTSHFSVLSFTPRPQDHNTDLTCHVDFSRKGVSAQRTVRLRVAYAPRDLVI 243

Query: 246 NSS-----------------VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA---VA 285
           + S                 +EA +G  + LLC ADS PP  L+W+    VL  +     
Sbjct: 244 SISRDNTPALEPQPQGNVPYLEAQKGQFLRLLCAADSQPPATLSWVLQNRVLSSSHPWGP 303

Query: 286 ESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTV-------------- 331
             L LEL  V   + G Y C AEN  G   R + LSV Y P    V              
Sbjct: 304 RPLGLELPGVKAGDSGRYTCRAENRLGSQQRALDLSVQYPPENLRVMVSQANRTVLENLG 363

Query: 332 NGTMVAV-EGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEY 390
           NGT + V EG+++ ++C T S+P   L+  +  Q+LS         LELP V  E +GE+
Sbjct: 364 NGTSLPVLEGQSLCLVCVTHSSPPARLSWTQRGQVLSPSQPSDPGVLELPRVQVEHEGEF 423

Query: 391 WCVAENQYGQRATAFNLSVEFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRN 450
            C A +  G +  + +LSV ++P LL  S C+   + + C C  +++P PS+ + L    
Sbjct: 424 TCHARHPLGSQHVSLSLSVHYSPKLLGPS-CSWEAEGLHCSCSSQASPAPSLRWWLGEEL 482

Query: 451 VTVNESEREF-VYSERSGLVLTSILTLRGQAQAPPRVICTARNLYGAKS---LELP-FQG 505
           +  N S+  F V    +G    S L+L G   +  R+ C A N++GA+S   L+LP  +G
Sbjct: 483 LEGNSSQDSFEVTPSSAGPWANSSLSLHGGLSSGLRLRCEAWNVHGAQSGSILQLPDKKG 542

Query: 506 AHRLMWAKIGPVG---AVVAFAILIAIVCYITQTRRKKNVTESPSFS 549
                ++    +G     + F  L  I+  I   RR +  T  P FS
Sbjct: 543 LISTAFSNGAFLGIGITALLFLCLALIIMKILPKRRTQTETPRPRFS 589


>gi|205830470 sialic acid binding Ig-like lectin 11 isoform 1 [Homo
           sapiens]
          Length = 698

 Score =  171 bits (432), Expect = 2e-42
 Identities = 143/510 (28%), Positives = 226/510 (44%), Gaps = 58/510 (11%)

Query: 34  EGTCVSIPCRFDFP----DELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRS 89
           EG CV + C   +P    DE   A  +G W+     PK   PV   ++++ V  S + R 
Sbjct: 46  EGLCVIVSCNLSYPRDGWDESTAA--YGYWFKGRTSPKTGAPVATNNQSREVEMSTRDRF 103

Query: 90  RLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYNQYTFSEHS----VLDIVNTPNIVV 145
           +L GD G  +C+L++ +   E    Y+FR + G   +++F  ++    V  +   P++ +
Sbjct: 104 QLTGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTALTKKPDVYI 163

Query: 146 PPEVVAGTEVEVSCMVP---DNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLL 202
           P  +  G  V V C+       CP   P  SW G       A L   R    T    S+L
Sbjct: 164 PETLEPGQPVTVICVFNWAFKKCP--APSFSWTG-------AALSPRRTRPST-SHFSVL 213

Query: 203 HFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP---VIVEMNSSVEAIE------ 253
            F P+ + +   L C   F    +  +    + V Y P   +I   + +  A+E      
Sbjct: 214 SFTPSPQDHDTDLTCHVDFSRKGVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVI 273

Query: 254 ------GSHVSLLCGADSNPPPLLTWMRDGTVLREA---VAESLLLELEEVTPAEDGVYA 304
                 G  + LLC ADS PP  L+W+    VL  +      +L LEL  V   + G Y 
Sbjct: 274 YLEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYT 333

Query: 305 CLAENAYGQDNRTVGLSVMYAPWKPTV--------------NGTMVAV-EGETVSILCST 349
           C AEN  G   + + LSV Y P    V              NGT + V EG+++ ++C T
Sbjct: 334 CRAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVT 393

Query: 350 QSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSV 409
            S+P   L+  +  Q +          LELP +  E +GE+ C A++  G +  + +LSV
Sbjct: 394 HSSPPARLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQHPLGSQHVSLSLSV 453

Query: 410 EFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREF-VYSERSGL 468
            + P LL  S C+   + + C C  +++P PS+ + L    +  N S+  F V    +G 
Sbjct: 454 HYPPQLLGPS-CSWEAEGLHCSCSSQASPAPSLRWWLGEELLEGNSSQGSFEVTPSSAGP 512

Query: 469 VLTSILTLRGQAQAPPRVICTARNLYGAKS 498
              S L+L G   +  R+ C A N++GA+S
Sbjct: 513 WANSSLSLHGGLSSGLRLRCKAWNVHGAQS 542


>gi|13489095 sialoadhesin precursor [Homo sapiens]
          Length = 1709

 Score =  143 bits (361), Expect = 4e-34
 Identities = 111/422 (26%), Positives = 200/422 (47%), Gaps = 26/422 (6%)

Query: 7   LPLFWIMISASRGGH--WGAWMPSSISAFEGTCVSIPCRFDFPDELR-PAVVHGVWYFNS 63
           LP   ++ S    G   WG   P  +   +G+C+ IPC F FP ++  P  +  +WY++ 
Sbjct: 4   LPKLLLLASFFPAGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYD- 62

Query: 64  PYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGG 123
            Y      V   +  ++V   F+GR+  +G+   R C LLL ++ PE  G Y FR ++  
Sbjct: 63  -YSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISE 121

Query: 124 YNQYTFSEHSVLDIV---NTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGL 180
            N+++  + +++ +      P I  P E++ GTEV+ +C  P  C + +  L W G +  
Sbjct: 122 VNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPA 181

Query: 181 GEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP 240
                  +  E  G    +  LH   + + +G  L CQ S  N   Q E    + VKY P
Sbjct: 182 RSVTFNSQKFEPTGVG-HLETLHMAMSWQDHGRILRCQLSVANHRAQSE--IHLQVKYAP 238

Query: 241 VIVEM---NSSVEAIEGSHVSLLCGADSNPPPL--LTWMRDGTVLREAVAESLLLELEEV 295
             V++    S    + G  V+L C  +S+ P +  + W++DG  L+    ++ +L L + 
Sbjct: 239 KGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQ---TKTGVLHLPQA 295

Query: 296 TPAEDGVYACLAENAYGQ-DNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSN-P 353
             ++ GVY C AEN  G   +  + L +  A  + +  G +  +E +TV+++C+T +  P
Sbjct: 296 AWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPI--LENQTVTLVCNTPNEAP 353

Query: 354 DPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYG-QRATAFNLSVEFA 412
             +   + +  +L    +   L+L L   +  D G Y+C  +N +G +R+   ++ V   
Sbjct: 354 SDLRYSWYKNHVLLEDAHSHTLRLHL--ATRADTGFYFCEVQNVHGSERSGPVSVVVNHP 411

Query: 413 PV 414
           P+
Sbjct: 412 PL 413



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 51/218 (23%), Positives = 89/218 (40%), Gaps = 18/218 (8%)

Query: 243 VEMNSSVEAIEGSHVSLLCGADSNPPPLL--TWMRDGTVLREAVAESLLLELEEVTPAED 300
           V+++ +   +E   V+L+C   +  P  L  +W ++  +L +A + +L L L   T A+ 
Sbjct: 328 VQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHL--ATRADT 385

Query: 301 GVYACLAENAYGQDNR-TVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTI 359
           G Y C  +N +G +    V + V + P  P +   +    G    + CS  S P   L +
Sbjct: 386 GFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVL 445

Query: 360 FKEKQILSTVIYESE-------------LQLELPAVSPEDDGEYWCVAENQYGQRATAFN 406
                IL++   +S+             L+LE+  +   D GEY C A N  G   +  +
Sbjct: 446 SHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLD 505

Query: 407 LSVEFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVAF 444
                A +L+  +        V   C    +P P   F
Sbjct: 506 FHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARF 543



 Score = 59.7 bits (143), Expect = 8e-09
 Identities = 64/237 (27%), Positives = 99/237 (41%), Gaps = 34/237 (14%)

Query: 187  GRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMN 246
            G + EDEG ++                   C+AS  NT  Q    A  D +   V V   
Sbjct: 1056 GAMLEDEGVYI-------------------CEAS--NTLGQASASADFDAQAVNVQVWPG 1094

Query: 247  SSVEAIEGSHVSLLCGADSNPPPLLT--WMRDGTVLREAVAESLLLELEEVTPAEDGVYA 304
            ++V   EG  V+L C   +  P  LT  W +DG    +A +    + L  VT  +   Y 
Sbjct: 1095 ATVR--EGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHS----IPLPNVTVRDATSYR 1148

Query: 305  CLA--ENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKE 362
            C         + +R + L V+YAP    +   + +  G+   +LC+  S P   L +   
Sbjct: 1149 CGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHA 1208

Query: 363  KQILSTVIYES---ELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL 416
             ++L++    S    L+LEL    P D+G Y C A +  GQ  T+  L +E   V+L
Sbjct: 1209 GRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVIL 1265



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 95/388 (24%), Positives = 150/388 (38%), Gaps = 59/388 (15%)

Query: 194  GTWVQ---VSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVE 250
            G W+Q    + L F+    A+     CQA     T      A++ V Y P    ++S  +
Sbjct: 1298 GRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRP-AALQVLYAPQDAVLSSFRD 1356

Query: 251  AIEGSHVSLLCGADSNPPPLLTWMRDGTVLR---------------EAVAESLLLELEEV 295
            +   S   + C  DS PP  L    DG VL                +    +L L++++V
Sbjct: 1357 SRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV 1416

Query: 296  TPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDP 355
             PA D  Y C A+N  G  +    L V  A  +      +   EG  +++ C     P P
Sbjct: 1417 -PAGDDTYVCTAQNLLGSISTIGRLQVEGA--RVVAEPGLDVPEGAALNLSCRLLGGPGP 1473

Query: 356  I-----LTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATA-FNLSV 409
            +        + ++++ +    E    L    V+    G Y C+AE   G  A+A   L V
Sbjct: 1474 VGNSTFAWFWNDRRLHA----EPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRV 1529

Query: 410  EFAP----VLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSER 465
             + P    +++        R  + C   V S P  S+   L SR   V  S+ +   +E 
Sbjct: 1530 LYPPKTPTMMVFVEPEGGLRGILDCR--VDSEPLASLTLHLGSR--LVASSQPQGAPAEP 1585

Query: 466  SGLVLTSILTLRGQAQA-----PPRVICTARNLYGAKSLELPF--QGAHR------LMWA 512
               VL S   LR   +A         IC+A N+ G+ S    F  +  HR      L+W 
Sbjct: 1586 HIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVRALHRLHQFQQLLWV 1645

Query: 513  KIGPVGAVVAFAILIAIV--CYITQTRR 538
                +G +V   +L+  +  CY  + RR
Sbjct: 1646 ----LGLLVGLLLLLLGLGACYTWRRRR 1669



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 58/249 (23%), Positives = 98/249 (39%), Gaps = 22/249 (8%)

Query: 253 EGSHVSLLCGAD---SNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDGVYAC-LAE 308
           EG+  +L C      +  P   +W R+G +  +   E++ L    V   +  +YAC +  
Sbjct: 721 EGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETVTLL--PVARTDAALYACRILT 778

Query: 309 NAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILST 368
            A  Q +  V LSV+Y P +P ++  +   +G     +C+  S P  +L +F  + +L+T
Sbjct: 779 EAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLAT 838

Query: 369 VI--------------YESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPV 414
            +                + L+LE+  +   D G Y C A N  G   T+    V  A V
Sbjct: 839 SLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWV 898

Query: 415 LLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSIL 474
            +  S        V   C V +      ++        + ES    +    + + LT   
Sbjct: 899 QVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATL--RFAAITLTQAG 956

Query: 475 TLRGQAQAP 483
               QAQAP
Sbjct: 957 AYHCQAQAP 965



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 58/249 (23%), Positives = 95/249 (38%), Gaps = 37/249 (14%)

Query: 243  VEMNSSVEAIEGSHVSLLCGADSNPPPLLT--WMRDGTVLREAVAESLLLELEEVTPAED 300
            V+++ S E  EG  V L C   +  P   +  W RDG  L+E+   S  L    +T  + 
Sbjct: 898  VQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST--SATLRFAAITLTQA 955

Query: 301  GVYACLAE---NAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPIL 357
            G Y C A+   +A       + L V YAP   T+   M    G    +LC   S+P   L
Sbjct: 956  GAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQL 1015

Query: 358  TIFKEKQILSTVIY-----------------ESELQLELPAVSPEDDGEYWCVAENQYGQ 400
             +    +++++ +                   + L+LE+     ED+G Y C A N  GQ
Sbjct: 1016 RLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQ 1075

Query: 401  RATAFNLSVEFAPVLLLESHCAAARDTVQCLCVV-------------KSNPEPSVAFELP 447
             + + +   +   V +           V   C+V             +   +   A  +P
Sbjct: 1076 ASASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSIP 1135

Query: 448  SRNVTVNES 456
              NVTV ++
Sbjct: 1136 LPNVTVRDA 1144



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 52/228 (22%), Positives = 89/228 (39%), Gaps = 31/228 (13%)

Query: 245 MNSSVEAIEGSHVSLLCGADSNPPP--LLTWMRDGTVLREAVAESLLLELEEVTPAEDGV 302
           ++ + E +EG  V+L C +  +P P    +W  +G +L E    SLLL     T A  G 
Sbjct: 515 ISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSSLLLPAASSTDA--GS 572

Query: 303 YACLAENAYGQDNRT--VGLSVMYAPWKPTVNGTMV-----AVEGETVSILCSTQSNPDP 355
           Y C A + +     +    L+V+Y P +PT    +      A  G    +LC   S+P  
Sbjct: 573 YHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPA 632

Query: 356 ILTIFKEKQILSTVIYESE--------------------LQLELPAVSPEDDGEYWCVAE 395
            L +  + ++++T +                        L++E+     E++G Y C A 
Sbjct: 633 RLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEAS 692

Query: 396 NQYGQRATAFNLSVEFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVA 443
           N  G  +T+   + +   + +  SH           C V      S A
Sbjct: 693 NALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPA 740



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 95/398 (23%), Positives = 144/398 (36%), Gaps = 70/398 (17%)

Query: 147  PEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVP 206
            PE+  G  V +SC V    PE      W       + +    LR    T  Q    H   
Sbjct: 904  PELQEGQAVVLSCQVHTGVPE-GTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYH--- 959

Query: 207  TREANGHRLGCQASFPNT-TLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADS 265
                      CQA  P + T       S+ V Y P  V + + ++   G    LLC  DS
Sbjct: 960  ----------CQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDS 1009

Query: 266  NPPPLLTWMR---------------DGTVLREAVA---ESLLLELEEVTPAEDGVYACLA 307
            +PP  L  +                +G+  R  VA    +L LE+      ++GVY C A
Sbjct: 1010 DPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEA 1069

Query: 308  ENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILS 367
             N  GQ + +          +     T+   EG+ V++ C        ++      Q+  
Sbjct: 1070 SNTLGQASASADFDAQAVNVQVWPGATV--REGQLVNLTC--------LVWTTHPAQLTY 1119

Query: 368  TVIYESELQLE-----LPAVSPEDDGEYWCVA--ENQYGQRATAFNLSVEFAP-----VL 415
            T   + + +L+     LP V+  D   Y C      +  + +    L V +AP       
Sbjct: 1120 TWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTY 1179

Query: 416  LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILT 475
            LLESH          LC V S P   +A         ++ + R    S  + +  T  L 
Sbjct: 1180 LLESH---GGQLALVLCTVDSRPPAQLA---------LSHAGRLLASSTAASVPNTLRLE 1227

Query: 476  LRG-QAQAPPRVICTARNLYGA--KSLELPFQGAHRLM 510
            LRG Q +      C+AR+  G    SLEL  +G   ++
Sbjct: 1228 LRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVIL 1265



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 44/182 (24%), Positives = 71/182 (39%), Gaps = 19/182 (10%)

Query: 230 GYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAE--- 286
           G  S+ V +PP+   + + +E   G    L C   S P   L     G +L     +   
Sbjct: 402 GPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDH 461

Query: 287 -----------SLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTM 335
                      SL LE+ ++   + G Y C A N+ G    T+      A  +  ++   
Sbjct: 462 SPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAA--RLLISPAA 519

Query: 336 VAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESE-LQLELPAVSPEDDGEYWCVA 394
             VEG+ V++ C +  +P P         +   +++E     L LPA S  D G Y C A
Sbjct: 520 EVVEGQAVTLSCRSGLSPTPDARF--SWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRA 577

Query: 395 EN 396
            +
Sbjct: 578 RD 579



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 63/282 (22%), Positives = 100/282 (35%), Gaps = 39/282 (13%)

Query: 152 GTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSL--LHFVPTRE 209
           GTE  ++C V                E  G PA     R     W Q  L  +  +P   
Sbjct: 722 GTEANLTCNV--------------SREAAGSPANFSWFRNGV-LWAQGPLETVTLLPVAR 766

Query: 210 ANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPP 269
            +     C+        Q      + V YPP   ++++ ++  +G     +C  DS P  
Sbjct: 767 TDAALYACRI-LTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLA 825

Query: 270 LLTWMR---------------DGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQD 314
           LL                    G    +A A SL LE+ E+   + G Y C A N  G  
Sbjct: 826 LLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSS 885

Query: 315 NRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESE 374
           N ++   V  A W   V+ +    EG+ V + C   +   P  T ++  +    +   + 
Sbjct: 886 NTSLFFQVRGA-W-VQVSPSPELQEGQAVVLSCQVHTGV-PEGTSYRWYRDGQPLQESTS 942

Query: 375 LQLELPAVSPEDDGEYWCVAE---NQYGQRATAFNLSVEFAP 413
             L   A++    G Y C A+   +     A   +L V +AP
Sbjct: 943 ATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAP 984


>gi|205830473 sialic acid binding Ig-like lectin 11 isoform 2 [Homo
           sapiens]
          Length = 602

 Score =  139 bits (349), Expect = 1e-32
 Identities = 116/422 (27%), Positives = 182/422 (43%), Gaps = 56/422 (13%)

Query: 34  EGTCVSIPCRFDFP----DELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRS 89
           EG CV + C   +P    DE   A  +G W+     PK   PV   ++++ V  S + R 
Sbjct: 46  EGLCVIVSCNLSYPRDGWDESTAA--YGYWFKGRTSPKTGAPVATNNQSREVEMSTRDRF 103

Query: 90  RLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYNQYTFSEHS----VLDIVNTPNIVV 145
           +L GD G  +C+L++ +   E    Y+FR + G   +++F  ++    V  +   P++ +
Sbjct: 104 QLTGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTALTKKPDVYI 163

Query: 146 PPEVVAGTEVEVSCMVP---DNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLL 202
           P  +  G  V V C+       CP   P  SW G       A L   R    T    S+L
Sbjct: 164 PETLEPGQPVTVICVFNWAFKKCP--APSFSWTG-------AALSPRRTRPST-SHFSVL 213

Query: 203 HFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP---VIVEMNSSVEAIE------ 253
            F P+ + +   L C   F    +  +    + V Y P   +I   + +  A+E      
Sbjct: 214 SFTPSPQDHDTDLTCHVDFSRKGVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVI 273

Query: 254 ------GSHVSLLCGADSNPPPLLTWMRDGTVLREA---VAESLLLELEEVTPAEDGVYA 304
                 G  + LLC ADS PP  L+W+    VL  +      +L LEL  V   + G Y 
Sbjct: 274 YLEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYT 333

Query: 305 CLAENAYGQDNRTVGLSVMYAPWKPTV--------------NGTMVAV-EGETVSILCST 349
           C AEN  G   + + LSV Y P    V              NGT + V EG+++ ++C T
Sbjct: 334 CRAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVT 393

Query: 350 QSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSV 409
            S+P   L+  +  Q +          LELP +  E +GE+ C A++  G +  + +LSV
Sbjct: 394 HSSPPARLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQHPLGSQHVSLSLSV 453

Query: 410 EF 411
            +
Sbjct: 454 HW 455



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 36/115 (31%), Positives = 55/115 (47%), Gaps = 17/115 (14%)

Query: 316 RTVGLSVMYAPWKPTVN------------GTMVAVE---GETVSILCSTQSNPDPILTIF 360
           RTV L V YAP    ++            G ++ +E   G+ + +LC+  S P   L+  
Sbjct: 241 RTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFLRLLCAADSQPPATLSWV 300

Query: 361 KEKQILSTVIY--ESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAP 413
            + ++LS+        L LEL  V   D G Y C AEN+ G +  A +LSV++ P
Sbjct: 301 LQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTCRAENRLGSQQQALDLSVQYPP 355


>gi|7657570 sialic acid binding Ig-like lectin 7 isoform 1 [Homo
           sapiens]
          Length = 467

 Score =  128 bits (322), Expect = 1e-29
 Identities = 98/368 (26%), Positives = 163/368 (44%), Gaps = 39/368 (10%)

Query: 1   MIFLTALPLFW----IMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFP--DELRPAV 54
           M+ L  LPL W    +    S    +   M SS++  EG CV + C F +P   +     
Sbjct: 1   MLLLLLLPLLWGRERVEGQKSNRKDYSLTMQSSVTVQEGMCVHVRCSFSYPVDSQTDSDP 60

Query: 55  VHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGK 114
           VHG W+          PV   +    V E  + R  LLGD   +NCTL + +      G+
Sbjct: 61  VHGYWFRAGNDISWKAPVATNNPAWAVQEETRDRFHLLGDPQTKNCTLSIRDARMSDAGR 120

Query: 115 YYFRGDLGGYN-QYTFSEHSV--LDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPE-LRP 170
           Y+FR + G     Y + + SV    + + PNI++P  + +G    ++C VP  C +   P
Sbjct: 121 YFFRMEKGNIKWNYKYDQLSVNVTALTHRPNILIPGTLESGCFQNLTCSVPWACEQGTPP 180

Query: 171 ELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEG 230
            +SW+G            +     +  + S+L  +P  + +G  L CQ + P   +    
Sbjct: 181 MISWMGTS----------VSPLHPSTTRSSVLTLIPQPQHHGTSLTCQVTLPGAGVTTNR 230

Query: 231 YASMDVKYPPVIVEM---------------NSSVEAIEGSHVSLLCGADSNPPPLLTW-M 274
              ++V YPP  + +               +SS+  +EG  + L+C  DSNPP  L+W  
Sbjct: 231 TIQLNVSYPPQNLTVTVFQGEGTASTALGNSSSLSVLEGQSLRLVCAVDSNPPARLSWTW 290

Query: 275 RDGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVM--YAPWKPTVN 332
           R  T+     +  L+LEL +V   ++G + C A+N+ G  + ++ LS+   Y      V+
Sbjct: 291 RSLTLYPSQPSNPLVLEL-QVHLGDEGEFTCRAQNSLGSQHVSLNLSLQQEYTGKMRPVS 349

Query: 333 GTMVAVEG 340
           G ++   G
Sbjct: 350 GVLLGAVG 357



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 42/165 (25%), Positives = 70/165 (42%), Gaps = 19/165 (11%)

Query: 264 DSNPPPLLTWMRDG-TVLREAVAESLLLELEEVTPAEDGVYACLAE--NAYGQDNRTVGL 320
           +   PP+++WM    + L  +   S +L L            C      A    NRT+ L
Sbjct: 175 EQGTPPMISWMGTSVSPLHPSTTRSSVLTLIPQPQHHGTSLTCQVTLPGAGVTTNRTIQL 234

Query: 321 SVMYAPWKPTV---------------NGTMVAVEGETVSILCSTQSNPDPILTIFKEKQI 365
           +V Y P   TV               + ++  +EG+++ ++C+  SNP   L+       
Sbjct: 235 NVSYPPQNLTVTVFQGEGTASTALGNSSSLSVLEGQSLRLVCAVDSNPPARLSWTWRSLT 294

Query: 366 LSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVE 410
           L      + L LEL  V   D+GE+ C A+N  G +  + NLS++
Sbjct: 295 LYPSQPSNPLVLELQ-VHLGDEGEFTCRAQNSLGSQHVSLNLSLQ 338


>gi|94538343 sialic acid binding Ig-like lectin 8 [Homo sapiens]
          Length = 499

 Score =  127 bits (318), Expect = 4e-29
 Identities = 99/381 (25%), Positives = 160/381 (41%), Gaps = 45/381 (11%)

Query: 1   MIFLTALPLFWIMISASRGGHWG----AWMPSSISAFEGTCVSIPCRFDFPDE--LRPAV 54
           ++ L  LPL W          +G      +   ++  EG CV +PC F +P +       
Sbjct: 2   LLLLLLLPLLWGTKGMEGDRQYGDGYLLQVQELVTVQEGLCVHVPCSFSYPQDGWTDSDP 61

Query: 55  VHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGK 114
           VHG W+     P    PV   +  + V    QGR +LLGD+   +C+L + +      G 
Sbjct: 62  VHGYWFRAGDRPYQDAPVATNNPDREVQAETQGRFQLLGDIWSNDCSLSIRDARKRDKGS 121

Query: 115 YYFRGDLGGYN-------QYTFSEHSVL--DIVNTPNIVVPPEVVAGTEVEVSCMVPDNC 165
           Y+FR + G           Y   + SV    + + P+I++   + +G    ++C VP  C
Sbjct: 122 YFFRLERGSMKWSYKSQLNYKTKQLSVFVTALTHRPDILILGTLESGHSRNLTCSVPWAC 181

Query: 166 PE-LRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNT 224
            +   P +SW+G            +     T  + S+L   P  + +G  L CQ + P T
Sbjct: 182 KQGTPPMISWIG----------ASVSSPGPTTARSSVLTLTPKPQDHGTSLTCQVTLPGT 231

Query: 225 TLQFEGYASMDVKYPPVIVEM---------------NSSVEAIEGSHVSLLCGADSNPPP 269
            +       +DV YPP  + M                SS+  +EG  + L+C  +SNPP 
Sbjct: 232 GVTTTSTVRLDVSYPPWNLTMTVFQGDATASTALGNGSSLSVLEGQSLRLVCAVNSNPPA 291

Query: 270 LLTWMRDG-TVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVM---YA 325
            L+W R   T+     +   LLEL  V   ++G + C A+NA G  + ++ LS+      
Sbjct: 292 RLSWTRGSLTLCPSRSSNPGLLELPRVHVRDEGEFTCRAQNAQGSQHISLSLSLQNEGTG 351

Query: 326 PWKPTVNGTMVAVEGETVSIL 346
             +P    T+ AV G   + L
Sbjct: 352 TSRPVSQVTLAAVGGAGATAL 372



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 33/109 (30%), Positives = 54/109 (49%), Gaps = 15/109 (13%)

Query: 317 TVGLSVMYAPWKPTV--------------NGTMVAV-EGETVSILCSTQSNPDPILTIFK 361
           TV L V Y PW  T+              NG+ ++V EG+++ ++C+  SNP   L+  +
Sbjct: 238 TVRLDVSYPPWNLTMTVFQGDATASTALGNGSSLSVLEGQSLRLVCAVNSNPPARLSWTR 297

Query: 362 EKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVE 410
               L      +   LELP V   D+GE+ C A+N  G +  + +LS++
Sbjct: 298 GSLTLCPSRSSNPGLLELPRVHVRDEGEFTCRAQNAQGSQHISLSLSLQ 346


>gi|4502659 sialic acid binding Ig-like lectin 5 [Homo sapiens]
          Length = 551

 Score =  121 bits (303), Expect = 2e-27
 Identities = 111/435 (25%), Positives = 181/435 (41%), Gaps = 48/435 (11%)

Query: 1   MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFP--DELRPAVVHGV 58
           M+ L  LPL W   S      +   +  S++  EG CV +PC F +P         ++  
Sbjct: 1   MLPLLLLPLLWGG-SLQEKPVYELQVQKSVTVQEGLCVLVPCSFSYPWRSWYSSPPLYVY 59

Query: 59  WYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFR 118
           W+ +   P     V   +  + V    QGR RLLGD+  +NC+L + +   E  G Y+FR
Sbjct: 60  WFRDGEIPYYAEVVATNNPDRRVKPETQGRFRLLGDVQKKNCSLSIGDARMEDTGSYFFR 119

Query: 119 GDLGGYNQYTFSEH----SVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPEL-- 172
            + G   +Y++ ++     V  ++  P+I     + +G    +SC +P +C E  P L  
Sbjct: 120 VERGRDVKYSYQQNKLNLEVTALIEKPDIHFLEPLESGRPTRLSCSLPGSC-EAGPPLTF 178

Query: 173 SWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYA 232
           SW G+           L   +    + S L   P  E +G  L CQ       +  E   
Sbjct: 179 SWTGN----------ALSPLDPETTRSSELTLTPRPEDHGTNLTCQMKRQGAQVTTERTV 228

Query: 233 SMDVKYPP------------VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVL 280
            ++V Y P             I++  S +  +EG  + LLC A SNPP  L+W +    L
Sbjct: 229 QLNVSYAPQTITIFRNGIALEILQNTSYLPVLEGQALRLLCDAPSNPPAHLSWFQGSPAL 288

Query: 281 REA-VAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVE 339
               ++ + +LEL  V  AE+G + C A++  G     + LSV      P + G   + E
Sbjct: 289 NATPISNTGILELRRVRSAEEGGFTCRAQHPLGFLQIFLNLSVYSL---PQLLGPSCSWE 345

Query: 340 GETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSP------------EDD 387
            E +   CS ++ P P L    E++ L     +   ++   +  P              D
Sbjct: 346 AEGLHCRCSFRARPAPSLCWRLEEKPLEGNSSQGSFKVNSSSAGPWANSSLILHGGLSSD 405

Query: 388 GEYWCVAENQYGQRA 402
            +  C A N YG ++
Sbjct: 406 LKVSCKAWNIYGSQS 420



 Score = 89.7 bits (221), Expect = 7e-18
 Identities = 101/392 (25%), Positives = 161/392 (41%), Gaps = 33/392 (8%)

Query: 258 SLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDGVYACLA-----ENAYG 312
           SL    ++ PP   +W   G  L     E+       +TP  +     L      + A  
Sbjct: 165 SLPGSCEAGPPLTFSWT--GNALSPLDPETTRSSELTLTPRPEDHGTNLTCQMKRQGAQV 222

Query: 313 QDNRTVGLSVMYAPWKPTV--NGTMVAV----------EGETVSILCSTQSNPDPILTIF 360
              RTV L+V YAP   T+  NG  + +          EG+ + +LC   SNP   L+ F
Sbjct: 223 TTERTVQLNVSYAPQTITIFRNGIALEILQNTSYLPVLEGQALRLLCDAPSNPPAHLSWF 282

Query: 361 KEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESH 420
           +    L+     +   LEL  V   ++G + C A++  G      NLSV   P LL  S 
Sbjct: 283 QGSPALNATPISNTGILELRRVRSAEEGGFTCRAQHPLGFLQIFLNLSVYSLPQLLGPS- 341

Query: 421 CAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREF-VYSERSGLVLTSILTLRGQ 479
           C+   + + C C  ++ P PS+ + L  + +  N S+  F V S  +G    S L L G 
Sbjct: 342 CSWEAEGLHCRCSFRARPAPSLCWRLEEKPLEGNSSQGSFKVNSSSAGPWANSSLILHGG 401

Query: 480 AQAPPRVICTARNLYGAKS-LELPFQGAHRL----MWAKIGPVGAVVAFAILIAIVCYIT 534
             +  +V C A N+YG++S   L  QG   L    + A +G  G +    I + ++ ++ 
Sbjct: 402 LSSDLKVSCKAWNIYGSQSGSVLLLQGRSNLGTGVVPAALGGAGVMALLCICLCLIFFLI 461

Query: 535 QTRRKKNVTESPSFSAGDNPPVL--FSSDFRISGAPEKYESERRLGSERRLLGLRGEPPE 592
              R+K     P     D  P++   +S  R    P+    +     +   L  + E   
Sbjct: 462 VKARRKQAAGRPE-KMDDEDPIMGTITSGSRKKPWPDSPGDQASPPGDAPPLEEQKELHY 520

Query: 593 LDLSYSHSDLGKRPTKDSYTLTEELAEYAEIR 624
             LS+  S++  R  KD         EY+EI+
Sbjct: 521 ASLSF--SEMKSREPKDQE--APSTTEYSEIK 548


>gi|23943856 sialic acid binding Ig-like lectin 9 [Homo sapiens]
          Length = 463

 Score =  119 bits (298), Expect = 8e-27
 Identities = 98/375 (26%), Positives = 159/375 (42%), Gaps = 41/375 (10%)

Query: 2   IFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDE--LRPA-VVHGV 58
           + L  LPL W    A         M SS++  EG CV +PC F +P    + P  VVHG 
Sbjct: 1   MLLLLLPLLWGRERAEGQTSKLLTMQSSVTVQEGLCVHVPCSFSYPSHGWIYPGPVVHGY 60

Query: 59  WYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFR 118
           W+          PV   +  + V E  + R  LLGD   +NCTL + +      G+Y+FR
Sbjct: 61  WFREGANTDQDAPVATNNPARAVWEETRDRFHLLGDPHTKNCTLSIRDARRSDAGRYFFR 120

Query: 119 GDLGGYNQYTFSEH----SVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPE-LRPELS 173
            + G   ++ +  H    +V  + + PNI++P  + +G    ++C VP  C +   P +S
Sbjct: 121 MEKGSI-KWNYKHHRLSVNVTALTHRPNILIPGTLESGCPQNLTCSVPWACEQGTPPMIS 179

Query: 174 WLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYAS 233
           W+G            +   + +  + S+L  +P  + +G  L CQ +FP  ++       
Sbjct: 180 WIGTS----------VSPLDPSTTRSSVLTLIPQPQDHGTSLTCQVTFPGASVTTNKTVH 229

Query: 234 MDVKYPP---------------VIVEMNSSVEAIEGSHVSLLC---GADSNPPP--LLTW 273
           ++V YPP                ++   SS+   EG  + L+C     DSNPP    L+W
Sbjct: 230 LNVSYPPQNLTMTVFQGDGTVSTVLGNGSSLSLPEGQSLRLVCAVDAVDSNPPARLSLSW 289

Query: 274 MRDGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNG 333
            R  T+     +   +LEL  V   +   + C A+N  G     + +S+          G
Sbjct: 290 -RGLTLCPSQPSNPGVLELPWVHLRDAAEFTCRAQNPLGSQQVYLNVSLQSKATSGVTQG 348

Query: 334 TMVAVEGETVSILCS 348
            +V   G T  +  S
Sbjct: 349 -VVGGAGATALVFLS 362



 Score = 38.5 bits (88), Expect = 0.019
 Identities = 40/168 (23%), Positives = 70/168 (41%), Gaps = 21/168 (12%)

Query: 264 DSNPPPLLTWMRDG-TVLREAVAESLLLELEEVTPAEDGVYACLAE--NAYGQDNRTVGL 320
           +   PP+++W+    + L  +   S +L L            C      A    N+TV L
Sbjct: 171 EQGTPPMISWIGTSVSPLDPSTTRSSVLTLIPQPQDHGTSLTCQVTFPGASVTTNKTVHL 230

Query: 321 SVMYAPWKPTV--------------NGTMVAV-EGETVSILCSTQ---SNPDPILTIFKE 362
           +V Y P   T+              NG+ +++ EG+++ ++C+     SNP   L++   
Sbjct: 231 NVSYPPQNLTMTVFQGDGTVSTVLGNGSSLSLPEGQSLRLVCAVDAVDSNPPARLSLSWR 290

Query: 363 KQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVE 410
              L      +   LELP V   D  E+ C A+N  G +    N+S++
Sbjct: 291 GLTLCPSQPSNPGVLELPWVHLRDAAEFTCRAQNPLGSQQVYLNVSLQ 338


>gi|16506826 sialic acid binding immunoglobulin-like lectin-like
           protein 1 isoform b precursor [Homo sapiens]
          Length = 477

 Score =  118 bits (296), Expect = 1e-26
 Identities = 95/385 (24%), Positives = 162/385 (42%), Gaps = 41/385 (10%)

Query: 26  MPSSISAFEGTCVSIPCRFDFP--DELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHE 83
           +P S++  EG CVS+PC   +P  +    + V+G W+          PV   + +  V E
Sbjct: 37  VPESVTVQEGLCVSVPCSVLYPHYNWTASSPVYGSWFKEGADIPWDIPVATNTPSGKVQE 96

Query: 84  SFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYN-QYTFSEHS--VLDIVNT 140
              GR  LLGD    NC+L + +      GKYYF+ + G     Y + + S  V  + + 
Sbjct: 97  DTHGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVERGSRKWNYIYDKLSVHVTALTHM 156

Query: 141 PNIVVPPEVVAGTEVEVSCMVPDNCPE-LRPELSWLGHEGLGEPAVLGRLREDEGTWVQV 199
           P   +P  + +G    ++C VP  C +   P ++W+G            +   + T  + 
Sbjct: 157 PTFSIPGTLESGHPRNLTCSVPWACEQGTPPTITWMG----------ASVSSLDPTITRS 206

Query: 200 SLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEM-------------- 245
           S+L  +P  + +G  L CQ + P   +       +++ YPP  + M              
Sbjct: 207 SMLSLIPQPQDHGTSLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLR 266

Query: 246 -NSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESL-LLELEEVTPAEDGVY 303
             S++  +EG  + L+C  DSNPP  L+W      L  + + +L +LEL  V   ++G +
Sbjct: 267 NGSALSVLEGQSLHLVCAVDSNPPARLSWTWGSLTLSPSQSSNLGVLELPRVHVKDEGEF 326

Query: 304 ACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEK 363
            C A+N  G  + ++ LS+     +    G M  + G T+               +F   
Sbjct: 327 TCRAQNPLGSQHISLSLSL-----QNEYTGKMRPISGVTLGAF----GGAGATALVFLYF 377

Query: 364 QILSTVIYESELQLELPAVSPEDDG 388
            I+  V+     +   PAV   D G
Sbjct: 378 CIIFVVVRSCRKKSARPAVGVGDTG 402



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 44/166 (26%), Positives = 73/166 (43%), Gaps = 20/166 (12%)

Query: 264 DSNPPPLLTWMRDG-TVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQD---NRTVG 319
           +   PP +TWM    + L   +  S +L L    P + G          G      R V 
Sbjct: 182 EQGTPPTITWMGASVSSLDPTITRSSMLSLIP-QPQDHGTSLTCQVTLPGAGVTMTRAVR 240

Query: 320 LSVMYAPWKPTV--------------NGTMVAV-EGETVSILCSTQSNPDPILTIFKEKQ 364
           L++ Y P   T+              NG+ ++V EG+++ ++C+  SNP   L+      
Sbjct: 241 LNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVCAVDSNPPARLSWTWGSL 300

Query: 365 ILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVE 410
            LS     +   LELP V  +D+GE+ C A+N  G +  + +LS++
Sbjct: 301 TLSPSQSSNLGVLELPRVHVKDEGEFTCRAQNPLGSQHISLSLSLQ 346


>gi|16506828 sialic acid binding immunoglobulin-like lectin-like
           protein 1 isoform a precursor [Homo sapiens]
          Length = 595

 Score =  118 bits (296), Expect = 1e-26
 Identities = 95/385 (24%), Positives = 162/385 (42%), Gaps = 41/385 (10%)

Query: 26  MPSSISAFEGTCVSIPCRFDFP--DELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHE 83
           +P S++  EG CVS+PC   +P  +    + V+G W+          PV   + +  V E
Sbjct: 155 VPESVTVQEGLCVSVPCSVLYPHYNWTASSPVYGSWFKEGADIPWDIPVATNTPSGKVQE 214

Query: 84  SFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYN-QYTFSEHS--VLDIVNT 140
              GR  LLGD    NC+L + +      GKYYF+ + G     Y + + S  V  + + 
Sbjct: 215 DTHGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVERGSRKWNYIYDKLSVHVTALTHM 274

Query: 141 PNIVVPPEVVAGTEVEVSCMVPDNCPE-LRPELSWLGHEGLGEPAVLGRLREDEGTWVQV 199
           P   +P  + +G    ++C VP  C +   P ++W+G            +   + T  + 
Sbjct: 275 PTFSIPGTLESGHPRNLTCSVPWACEQGTPPTITWMG----------ASVSSLDPTITRS 324

Query: 200 SLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEM-------------- 245
           S+L  +P  + +G  L CQ + P   +       +++ YPP  + M              
Sbjct: 325 SMLSLIPQPQDHGTSLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLR 384

Query: 246 -NSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESL-LLELEEVTPAEDGVY 303
             S++  +EG  + L+C  DSNPP  L+W      L  + + +L +LEL  V   ++G +
Sbjct: 385 NGSALSVLEGQSLHLVCAVDSNPPARLSWTWGSLTLSPSQSSNLGVLELPRVHVKDEGEF 444

Query: 304 ACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEK 363
            C A+N  G  + ++ LS+     +    G M  + G T+               +F   
Sbjct: 445 TCRAQNPLGSQHISLSLSL-----QNEYTGKMRPISGVTLGAF----GGAGATALVFLYF 495

Query: 364 QILSTVIYESELQLELPAVSPEDDG 388
            I+  V+     +   PAV   D G
Sbjct: 496 CIIFVVVRSCRKKSARPAVGVGDTG 520



 Score = 83.2 bits (204), Expect = 7e-16
 Identities = 111/469 (23%), Positives = 180/469 (38%), Gaps = 66/469 (14%)

Query: 1   MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAV--VHGV 58
           ++ L   PL    + A     +   M  S++  EG CVS+ C F +P     A   VHG 
Sbjct: 3   LLLLLLPPLLCGRVGAKEQKDYLLTMQKSVTVQEGLCVSVLCSFSYPQNGWTASDPVHGY 62

Query: 59  WYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFR 118
           W+    +     PV   +  + V E  + R  LLGD   ++CTL + +      G Y F 
Sbjct: 63  WFRAGDHVSRNIPVATNNPARAVQEETRDRFHLLGDPQNKDCTLSIRDTRESDAGTYVFC 122

Query: 119 GDLGG------YNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPEL 172
            + G       Y+Q + +  +  D+++   + VP  V     V+    V   C  L P  
Sbjct: 123 VERGNMKWNYKYDQLSVNVTASQDLLSRYRLEVPESVT----VQEGLCVSVPCSVLYPHY 178

Query: 173 SWLG---------HEGLGEP--------AVLGRLREDEGTWVQVSLLHFVPTREAN-GHR 214
           +W            EG   P           G+++ED  T  +  LL    T   +   R
Sbjct: 179 NWTASSPVYGSWFKEGADIPWDIPVATNTPSGKVQED--THGRFLLLGDPQTNNCSLSIR 236

Query: 215 LGCQASFPNTTLQFE-GYASMDVKYPPVIVEMNSSVE--------AIEGSHV-SLLC--- 261
              +        Q E G    +  Y  + V + +            +E  H  +L C   
Sbjct: 237 DARKGDSGKYYFQVERGSRKWNYIYDKLSVHVTALTHMPTFSIPGTLESGHPRNLTCSVP 296

Query: 262 -GADSNPPPLLTWM-RDGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQD---NR 316
              +   PP +TWM    + L   +  S +L L    P + G          G      R
Sbjct: 297 WACEQGTPPTITWMGASVSSLDPTITRSSMLSLIP-QPQDHGTSLTCQVTLPGAGVTMTR 355

Query: 317 TVGLSVMYAPWKPTV--------------NGTMVAV-EGETVSILCSTQSNPDPILTIFK 361
            V L++ Y P   T+              NG+ ++V EG+++ ++C+  SNP   L+   
Sbjct: 356 AVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVCAVDSNPPARLSWTW 415

Query: 362 EKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVE 410
               LS     +   LELP V  +D+GE+ C A+N  G +  + +LS++
Sbjct: 416 GSLTLSPSQSSNLGVLELPRVHVKDEGEFTCRAQNPLGSQHISLSLSLQ 464


>gi|193794821 sialic acid binding Ig-like lectin 6 isoform 1
           precursor [Homo sapiens]
          Length = 453

 Score =  115 bits (289), Expect = 9e-26
 Identities = 102/363 (28%), Positives = 159/363 (43%), Gaps = 43/363 (11%)

Query: 7   LPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVV-HGVWYFNSPY 65
           LPL W    A     +    P S++  EG CV +PCR   P  L  +   +G W+     
Sbjct: 17  LPLLWAGALAQER-RFQLEGPESLTVQEGLCVLVPCRL--PTTLPASYYGYGYWFLEGAD 73

Query: 66  PKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYN 125
                PV      + V E  +GR  LL D   +NC+L + +        Y+FR       
Sbjct: 74  V----PVATNDPDEEVQEETRGRFHLLWDPRRKNCSLSIRDARRRDNAAYFFRLKSKWMK 129

Query: 126 Q-YTFSEHS--VLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPEL-SWLGHEGLG 181
             YT S+ S  V+ + + PNI +P  + +G    ++C VP  C +  P + SW+      
Sbjct: 130 YGYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQGTPPIFSWMS----A 185

Query: 182 EPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP- 240
            P  LG          Q S+L   P  + +   L CQ +FP   +  E    ++V Y P 
Sbjct: 186 APTSLG------PRTTQSSVLTITPRPQDHSTNLTCQVTFPGAGVTMERTIQLNVSYAPQ 239

Query: 241 --------------VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-VA 285
                          I++  SS+  +EG  + LLC AD NPP  L+W +    L    ++
Sbjct: 240 KVAISIFQGNSAAFKILQNTSSLPVLEGQALRLLCDADGNPPAHLSWFQGFPALNATPIS 299

Query: 286 ESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKP--TVNGTMVAVEGETV 343
            + +LEL +V  AE+G + C A++  G  +  + LS ++  WKP     G + AV G ++
Sbjct: 300 NTGVLELPQVGSAEEGDFTCRAQHPLG--SLQISLS-LFVHWKPEGRAGGVLGAVWGASI 356

Query: 344 SIL 346
           + L
Sbjct: 357 TTL 359



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 50/210 (23%), Positives = 84/210 (40%), Gaps = 26/210 (12%)

Query: 230 GYAS--MDVKYPPVIVEMNSSVEA-IEGSHVS-LLCGA----DSNPPPLLTWMRDG-TVL 280
           GY S  + V+   +    N S+   +E  H S L C      +   PP+ +WM    T L
Sbjct: 131 GYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQGTPPIFSWMSAAPTSL 190

Query: 281 REAVAESLLLELEEVTPAEDGVYACLAE--NAYGQDNRTVGLSVMYAPWKPTVN------ 332
                +S +L +            C      A     RT+ L+V YAP K  ++      
Sbjct: 191 GPRTTQSSVLTITPRPQDHSTNLTCQVTFPGAGVTMERTIQLNVSYAPQKVAISIFQGNS 250

Query: 333 ---------GTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVS 383
                     ++  +EG+ + +LC    NP   L+ F+    L+     +   LELP V 
Sbjct: 251 AAFKILQNTSSLPVLEGQALRLLCDADGNPPAHLSWFQGFPALNATPISNTGVLELPQVG 310

Query: 384 PEDDGEYWCVAENQYGQRATAFNLSVEFAP 413
             ++G++ C A++  G    + +L V + P
Sbjct: 311 SAEEGDFTCRAQHPLGSLQISLSLFVHWKP 340


>gi|157168355 CD22 molecule [Homo sapiens]
          Length = 847

 Score =  115 bits (288), Expect = 1e-25
 Identities = 130/465 (27%), Positives = 198/465 (42%), Gaps = 38/465 (8%)

Query: 14  ISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPD-ELRPAVVHGVWYFNSPYPKNYPPV 72
           ++ S    W    P ++ A+EG CV IPC +   D +L   ++    + N  Y KN    
Sbjct: 16  LAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFIL----FHNPEYNKNTSKF 71

Query: 73  ----VFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYNQYT 128
               +++S       S Q R + LGD   +NCTL +  V     G+   R +        
Sbjct: 72  DGTRLYESTKDGKVPSEQKRVQFLGDKN-KNCTLSIHPVHLNDSGQLGLRMESKTEKWME 130

Query: 129 FSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEG--LGEPAVL 186
               +V +    P+I +PPE+    EV ++C++  +C     +L WL  EG  + + AV 
Sbjct: 131 RIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWL-LEGVPMRQAAVT 189

Query: 187 GRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMN 246
                 +  + + S L F P    +G  + CQ    +          ++VK+ P +    
Sbjct: 190 STSLTIKSVFTR-SELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKV 248

Query: 247 SSVEAI--EGSHVSLLCGADSNPPPLLT--WMRDGTVLREAVAESLLLELEEVTPAEDGV 302
           +  +AI  EG  V++ C   S+ P   T  W++DGT L++    +  L L EVT  + G 
Sbjct: 249 TPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKK--QNTFTLNLREVTKDQSGK 306

Query: 303 YACLAENAYGQD-NRTVGLSVMYAPWKPTVNGT-MVAVEGETVSILCSTQSNPDPILTIF 360
           Y C   N  G   +  V L V YAP   TV      AVEG  V  LC + +NP P  T +
Sbjct: 307 YCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLP--TNY 364

Query: 361 KEKQILSTVIYESELQLELPAVSPEDDGEYWCVAEN--QYGQRATAFNLSVEFAP----V 414
                   +   +E ++ +P + P   G Y CVAEN    GQR     L V++ P     
Sbjct: 365 TWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTT 424

Query: 415 LLLESHCAAARDTVQCLC-VVKSNP-------EPSVAFELPSRNV 451
           ++         DTV   C    SNP       +P  A+E PS  V
Sbjct: 425 VIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGV 469



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 90/324 (27%), Positives = 136/324 (41%), Gaps = 34/324 (10%)

Query: 101 TLLLSNVSPELGGKYYFR--GDLG-GYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEV 157
           TL L  V+ +  GKY  +   D+G G ++  F +       +T  I+  P  V G++VE 
Sbjct: 293 TLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSP-AVEGSQVEF 351

Query: 158 SCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGC 217
            CM   N   L    +W  H G     + GR  E          +H       +     C
Sbjct: 352 LCMSLAN--PLPTNYTWY-HNG---KEMQGRTEEK---------VHIPKILPWHAGTYSC 396

Query: 218 QASFPNTTLQFEGYASMDVKYPP--VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLT--W 273
            A     T Q    A +DV+YPP  V   + + +   EG  V+L C  +S+ P +    W
Sbjct: 397 VAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEW 456

Query: 274 MRDGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNG 333
              G     ++    +L+++ V   ++   AC A N++      V L+V YAP    V  
Sbjct: 457 KPHGAWEEPSLG---VLKIQNVG-WDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRK 512

Query: 334 TMVAVE---GETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEY 390
                E   G +VS+ C   S+    +  F EK   +  +   E QL   ++SPED G Y
Sbjct: 513 IKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEK---NGRLLGKESQLNFDSISPEDAGSY 569

Query: 391 WCVAENQYGQRAT-AFNLSVEFAP 413
            C   N  GQ A+ A+ L V +AP
Sbjct: 570 SCWVNNSIGQTASKAWTLEVLYAP 593



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 68/278 (24%), Positives = 119/278 (42%), Gaps = 35/278 (12%)

Query: 146 PPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFV 205
           P  +  G  V +SC    + P +     W  H    EP+ LG L+     W   ++    
Sbjct: 429 PMPIREGDTVTLSCNYNSSNPSVT-RYEWKPHGAWEEPS-LGVLKIQNVGWDNTTI---- 482

Query: 206 PTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIE---GSHVSLLCG 262
                      C A   N+   +    +++V+Y P  V +       E   G+ VSL C 
Sbjct: 483 ----------ACAAC--NSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCD 530

Query: 263 ADSNPPPLLT--WMRDGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQD-NRTVG 319
             S+ P  +   W ++G +L     +   L  + ++P + G Y+C   N+ GQ  ++   
Sbjct: 531 FSSSHPKEVQFFWEKNGRLL----GKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWT 586

Query: 320 LSVMYAPWKPTVN---GTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQ 376
           L V+YAP +  V+   G  V +EG++ ++ C + +NP      + +    S   +  +L+
Sbjct: 587 LEVLYAPRRLRVSMSPGDQV-MEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLR 645

Query: 377 LELPAVSPEDDGEYWCVAENQYGQ-RATAFNLSVEFAP 413
           LE   V  +  G YWC   N  G+ R+    L+V ++P
Sbjct: 646 LE--PVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSP 681



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 34/118 (28%), Positives = 52/118 (44%), Gaps = 8/118 (6%)

Query: 233 SMDVKYPP--VIVEMNSSVEAIEGSHVSLLCGADSNPP-PLLTWMRDGTVLREAVAESLL 289
           +++V Y P  + V M+   + +EG   +L C +D+NPP    TW       +     S  
Sbjct: 586 TLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNN--QSLPYHSQK 643

Query: 290 LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVE-GETVSIL 346
           L LE V     G Y C   N+ G+    +    +Y  + P   G  VAV  G  ++IL
Sbjct: 644 LRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVY--YSPETIGRRVAVGLGSCLAIL 699


>gi|193794819 sialic acid binding Ig-like lectin 6 isoform 2
           precursor [Homo sapiens]
          Length = 437

 Score =  114 bits (285), Expect = 3e-25
 Identities = 100/348 (28%), Positives = 157/348 (45%), Gaps = 29/348 (8%)

Query: 7   LPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVV-HGVWYFNSPY 65
           LPL W    A     +    P S++  EG CV +PCR   P  L  +   +G W+     
Sbjct: 17  LPLLWAGALAQER-RFQLEGPESLTVQEGLCVLVPCRL--PTTLPASYYGYGYWFLEGAD 73

Query: 66  PKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYN 125
                PV      + V E  +GR  LL D   +NC+L + +        Y+FR       
Sbjct: 74  V----PVATNDPDEEVQEETRGRFHLLWDPRRKNCSLSIRDARRRDNAAYFFRLKSKWMK 129

Query: 126 Q-YTFSEHS--VLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPEL-SWLGHEGLG 181
             YT S+ S  V+ + + PNI +P  + +G    ++C VP  C +  P + SW+      
Sbjct: 130 YGYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQGTPPIFSWMS----A 185

Query: 182 EPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPV 241
            P  LG          Q S+L   P  + +   L CQ +FP   +  E    ++V     
Sbjct: 186 APTSLG------PRTTQSSVLTITPRPQDHSTNLTCQVTFPGAGVTMERTIQLNVS-SFK 238

Query: 242 IVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-VAESLLLELEEVTPAED 300
           I++  SS+  +EG  + LLC AD NPP  L+W +    L    ++ + +LEL +V  AE+
Sbjct: 239 ILQNTSSLPVLEGQALRLLCDADGNPPAHLSWFQGFPALNATPISNTGVLELPQVGSAEE 298

Query: 301 GVYACLAENAYGQDNRTVGLSVMYAPWKP--TVNGTMVAVEGETVSIL 346
           G + C A++  G  +  + LS ++  WKP     G + AV G +++ L
Sbjct: 299 GDFTCRAQHPLG--SLQISLS-LFVHWKPEGRAGGVLGAVWGASITTL 343



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 49/196 (25%), Positives = 82/196 (41%), Gaps = 14/196 (7%)

Query: 230 GYAS--MDVKYPPVIVEMNSSVEA-IEGSHVS-LLCGA----DSNPPPLLTWMRDG-TVL 280
           GY S  + V+   +    N S+   +E  H S L C      +   PP+ +WM    T L
Sbjct: 131 GYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQGTPPIFSWMSAAPTSL 190

Query: 281 REAVAESLLLELEEVTPAEDGVYACLAE--NAYGQDNRTVGLSVMYAPWKPTVNGTMVAV 338
                +S +L +            C      A     RT+ L+V  + +K   N + + V
Sbjct: 191 GPRTTQSSVLTITPRPQDHSTNLTCQVTFPGAGVTMERTIQLNV--SSFKILQNTSSLPV 248

Query: 339 -EGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQ 397
            EG+ + +LC    NP   L+ F+    L+     +   LELP V   ++G++ C A++ 
Sbjct: 249 LEGQALRLLCDADGNPPAHLSWFQGFPALNATPISNTGVLELPQVGSAEEGDFTCRAQHP 308

Query: 398 YGQRATAFNLSVEFAP 413
            G    + +L V + P
Sbjct: 309 LGSLQISLSLFVHWKP 324


>gi|148762980 sialic acid binding Ig-like lectin 14 [Homo sapiens]
          Length = 396

 Score =  110 bits (274), Expect = 5e-24
 Identities = 93/348 (26%), Positives = 145/348 (41%), Gaps = 38/348 (10%)

Query: 1   MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFP--DELRPAVVHGV 58
           M+ L  LPL W   S      +   +  S++  EG CV +PC F +P         ++  
Sbjct: 1   MLPLLLLPLLWGG-SLQEKPVYELQVQKSVTVQEGLCVLVPCSFSYPWRSWYSSPPLYVY 59

Query: 59  WYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFR 118
           W+ +   P     V   +  + V    QGR RLLGD+  +NC+L + +   E  G Y+FR
Sbjct: 60  WFRDGEIPYYAEVVATNNPDRRVKPETQGRFRLLGDVQKKNCSLSIGDARMEDTGSYFFR 119

Query: 119 GDLGGYNQYTFSEH----SVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPEL-- 172
            + G   +Y++ ++     V  ++  P+I     + +G    +SC +P +C E  P L  
Sbjct: 120 VERGRDVKYSYQQNKLNLEVTALIEKPDIHFLEPLESGRPTRLSCSLPGSC-EAGPPLTF 178

Query: 173 SWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYA 232
           SW G+           L   +    + S L   P  E +G  L CQ       +  E   
Sbjct: 179 SWTGN----------ALSPLDPETTRSSELTLTPRPEDHGTNLTCQVKRQGAQVTTERTV 228

Query: 233 SMDVKYPPV-----------------IVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMR 275
            ++V Y P                  I+    SV   EG  + L C  DSNPP  L+W R
Sbjct: 229 QLNVSYAPQNLAISIFFRNGTGTALRILSNGMSVPIQEGQSLFLACTVDSNPPASLSWFR 288

Query: 276 DGTVLREA-VAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSV 322
           +G  L  +  + S  LEL  +   E G + C  ++  G  + +  LSV
Sbjct: 289 EGKALNPSQTSMSGTLELPNIGAREGGEFTCRVQHPLGSQHLSFILSV 336



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 50/200 (25%), Positives = 80/200 (40%), Gaps = 38/200 (19%)

Query: 258 SLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDGVYACLA-----ENAYG 312
           SL    ++ PP   +W   G  L     E+       +TP  +     L      + A  
Sbjct: 165 SLPGSCEAGPPLTFSWT--GNALSPLDPETTRSSELTLTPRPEDHGTNLTCQVKRQGAQV 222

Query: 313 QDNRTVGLSVMYAPWKPTV-----NGTMVAV------------EGETVSILCSTQSNPDP 355
              RTV L+V YAP    +     NGT  A+            EG+++ + C+  SNP  
Sbjct: 223 TTERTVQLNVSYAPQNLAISIFFRNGTGTALRILSNGMSVPIQEGQSLFLACTVDSNPPA 282

Query: 356 ILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL 415
            L+ F+E + L+         LELP +   + GE+ C  ++  G +  +F LSV+     
Sbjct: 283 SLSWFREGKALNPSQTSMSGTLELPNIGAREGGEFTCRVQHPLGSQHLSFILSVQ----- 337

Query: 416 LLESHCAAARDTVQCLCVVK 435
                    R +  C+CV +
Sbjct: 338 ---------RSSSSCICVTE 348


>gi|193794817 sialic acid binding Ig-like lectin 6 isoform 3
           precursor [Homo sapiens]
          Length = 353

 Score =  109 bits (272), Expect = 9e-24
 Identities = 94/340 (27%), Positives = 147/340 (43%), Gaps = 38/340 (11%)

Query: 7   LPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVV-HGVWYFNSPY 65
           LPL W    A     +    P S++  EG CV +PCR   P  L  +   +G W+     
Sbjct: 17  LPLLWAGALAQER-RFQLEGPESLTVQEGLCVLVPCRL--PTTLPASYYGYGYWFLEGAD 73

Query: 66  PKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYN 125
                PV      + V E  +GR  LL D   +NC+L + +        Y+FR       
Sbjct: 74  V----PVATNDPDEEVQEETRGRFHLLWDPRRKNCSLSIRDARRRDNAAYFFRLKSKWMK 129

Query: 126 Q-YTFSEHS--VLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPEL-SWLGHEGLG 181
             YT S+ S  V+ + + PNI +P  + +G    ++C VP  C +  P + SW+      
Sbjct: 130 YGYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQGTPPIFSWMS----A 185

Query: 182 EPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP- 240
            P  LG          Q S+L   P  + +   L CQ +FP   +  E    ++V Y P 
Sbjct: 186 APTSLG------PRTTQSSVLTITPRPQDHSTNLTCQVTFPGAGVTMERTIQLNVSYAPQ 239

Query: 241 --------------VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-VA 285
                          I++  SS+  +EG  + LLC AD NPP  L+W +    L    ++
Sbjct: 240 KVAISIFQGNSAAFKILQNTSSLPVLEGQALRLLCDADGNPPAHLSWFQGFPALNATPIS 299

Query: 286 ESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYA 325
            + +LEL +V  AE+G + C A++  G    ++ L V ++
Sbjct: 300 NTGVLELPQVGSAEEGDFTCRAQHPLGSLQISLSLFVHWS 339



 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 50/217 (23%), Positives = 87/217 (40%), Gaps = 26/217 (11%)

Query: 230 GYAS--MDVKYPPVIVEMNSSVEA-IEGSHVS-LLCGA----DSNPPPLLTWMRDG-TVL 280
           GY S  + V+   +    N S+   +E  H S L C      +   PP+ +WM    T L
Sbjct: 131 GYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQGTPPIFSWMSAAPTSL 190

Query: 281 REAVAESLLLELEEVTPAEDGVYACLAE--NAYGQDNRTVGLSVMYAPWKPTVN------ 332
                +S +L +            C      A     RT+ L+V YAP K  ++      
Sbjct: 191 GPRTTQSSVLTITPRPQDHSTNLTCQVTFPGAGVTMERTIQLNVSYAPQKVAISIFQGNS 250

Query: 333 ---------GTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVS 383
                     ++  +EG+ + +LC    NP   L+ F+    L+     +   LELP V 
Sbjct: 251 AAFKILQNTSSLPVLEGQALRLLCDADGNPPAHLSWFQGFPALNATPISNTGVLELPQVG 310

Query: 384 PEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESH 420
             ++G++ C A++  G    + +L V ++   + + H
Sbjct: 311 SAEEGDFTCRAQHPLGSLQISLSLFVHWSSAPVPDRH 347


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score = 99.0 bits (245), Expect = 1e-20
 Identities = 106/388 (27%), Positives = 162/388 (41%), Gaps = 48/388 (12%)

Query: 142  NIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGL-----GEPAV---LGRLRE-D 192
            NI VPP +    E+    ++  N   L  E S +    L     G P +   +GR+R   
Sbjct: 2190 NIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILS 2249

Query: 193  EGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAI 252
             G  +Q+S+       +++     C AS    T + E   ++ V   P I    S    I
Sbjct: 2250 GGRQLQISI-----AEKSDAALYSCVASNVAGTAKKE--YNLQVYIRPTITNSGSHPTEI 2302

Query: 253  ---EGSHVSLLCGADSNPPPLLTWMRDGTVLREA-----VAESLLLELEEVTPAEDGVYA 304
                G  +SL C     PPP +TWM+DG  L +A     + E  +L+L+ +  ++ G Y 
Sbjct: 2303 IVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYV 2362

Query: 305  CLAENAYGQDNRTVGLSVMYAPWKPTVNG------TMVAVEGETVSILCSTQSNPDPILT 358
            C+A N  G  ++   LSV +AP  P++ G       +  VE  +VS+ C     P P +T
Sbjct: 2363 CVAVNVAGMTDKKYDLSV-HAP--PSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSIT 2419

Query: 359  IFKEKQIL----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPV 414
             FK+   +    S  I      L L   + ED G+Y CV  N  G+    F LSV   P 
Sbjct: 2420 WFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPH 2479

Query: 415  LL----LESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVL 470
            ++    LE      + +V   C V  NP P + +    +   + E E   + S    L +
Sbjct: 2480 IVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQ--PLQEDEAHHIISGGRFLQI 2537

Query: 471  TSILTLRGQAQAPPRVICTARNLYGAKS 498
            T++     Q     R  C A +  G KS
Sbjct: 2538 TNV-----QVPHTGRYTCLASSPAGHKS 2560



 Score = 94.0 bits (232), Expect = 4e-19
 Identities = 95/367 (25%), Positives = 163/367 (44%), Gaps = 47/367 (12%)

Query: 142  NIVVPPEVVAGTEVEVSCMVPDNCPELR--------PELSWLGHEGLGEPAVLGR--LRE 191
            N+ VPP V+ G + E   +V +N   L         P+LSWL +E   +P  L    L  
Sbjct: 2959 NVHVPPSVI-GPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNE---QPIKLNTNTLIV 3014

Query: 192  DEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSS--- 248
              G  +Q+     +  + ++G    C A   N   + +   S+ V  PP I + +S    
Sbjct: 3015 PGGRTLQI-----IRAKVSDGGEYTCIAI--NQAGESKKKFSLTVYVPPSIKDHDSESLS 3067

Query: 249  -VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-----VAESLLLELEEVTPAEDGV 302
             V   EG+ VSL C +++ PPP++TW ++G ++ E+     +A+  +L +++   ++ G 
Sbjct: 3068 VVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQ 3127

Query: 303  YACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVS----ILCSTQSNPDPILT 358
            Y C A N  G+D++   L+V Y P  P++ G    V  ET+S    + C     P P + 
Sbjct: 3128 YVCRAINVAGRDDKNFHLNV-YVP--PSIEGPEREVIVETISNPVTLTCDATGIPPPTIA 3184

Query: 359  IFK-EKQI-----LSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFA 412
              K  K+I     L   I     +L++      D G Y C+A N  G+    + LS++  
Sbjct: 3185 WLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVP 3244

Query: 413  PVL----LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGL 468
            P +    +         + V+ +C     P P + +    + +   E+ER  V +  S L
Sbjct: 3245 PSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTL 3304

Query: 469  VLTSILT 475
             +   LT
Sbjct: 3305 NIYGALT 3311



 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 88/366 (24%), Positives = 141/366 (38%), Gaps = 37/366 (10%)

Query: 149  VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTR 208
            V+AG EV + C V    P   P ++W     L  P           T++    +    TR
Sbjct: 1091 VLAGEEVTLPCEVKSLPP---PIITWAKETQLISPF------SPRHTFLPSGSMKITETR 1141

Query: 209  EANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPP 268
             ++     C A+  N          ++V  PP I      ++   G  V + C A   P 
Sbjct: 1142 TSDSGMYLCVAT--NIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPL 1199

Query: 269  PLLTWMRDGTVL-----REAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVM 323
            P++TW + G+ +              L +++ TP++ G+Y C+A N  G D   + L V 
Sbjct: 1200 PVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQ 1259

Query: 324  YAPW----KPTVNGTMVA-VEGETVSILCSTQSNPDPILTIFKEKQILS-----TVIYES 373
              P     +P  N T    V  + +   C  +  P P +      + L+       I E 
Sbjct: 1260 EPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILED 1319

Query: 374  ELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL----LLESHCAAARDTVQ 429
               L + +V+P D+GEY CVA N+ G     +NL V   PV+     + +          
Sbjct: 1320 GTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTN 1379

Query: 430  CLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQAQAPPRVICT 489
              C V+  P P + +     NV V ES    + +  +G +L      R   +   R  C 
Sbjct: 1380 LFCEVEGTPSPIIMWY--KDNVQVTESST--IQTVNNGKILK---LFRATPEDAGRYSCK 1432

Query: 490  ARNLYG 495
            A N+ G
Sbjct: 1433 AINIAG 1438



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 91/370 (24%), Positives = 156/370 (42%), Gaps = 46/370 (12%)

Query: 70   PPVVFKSRTQVVHESFQGRSRLLG-------DLGLRNCTLLLSNVSPELGGKYYFRGDLG 122
            P +++K +   V     GR R+L         +  ++   L S V+  + G         
Sbjct: 2226 PNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKE---- 2281

Query: 123  GYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGE 182
             YN   +   ++ +  + P  ++   V  G  + + C V    P   P ++W+     G 
Sbjct: 2282 -YNLQVYIRPTITNSGSHPTEII---VTRGKSISLECEVQGIPP---PTVTWMKD---GH 2331

Query: 183  PAVLGRLRE--DEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP 240
            P +  +  E  DEG  +Q+  +H   T      R  C A   N     +    + V  PP
Sbjct: 2332 PLIKAKGVEILDEGHILQLKNIHVSDTG-----RYVCVAV--NVAGMTDKKYDLSVHAPP 2384

Query: 241  VIVEMNSSVE---AIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-----LEL 292
             I+  + S E    +E + VSL C A   P P +TW +DG  +  + +  +L     L L
Sbjct: 2385 SIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRILSGGRMLRL 2444

Query: 293  EEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPW---KPTVNGTMVAVEGETVSILCST 349
             + T  + G Y C+  NA G++ +  GLSV+  P    + T+    V  E ++V++ C  
Sbjct: 2445 MQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVK-EKQSVTLTCEV 2503

Query: 350  QSNPDPILTIFKEKQILSTV----IYESELQLELPAVSPEDDGEYWCVAENQYGQRATAF 405
              NP P +T  K+ Q L       I      L++  V     G Y C+A +  G ++ +F
Sbjct: 2504 TGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSF 2563

Query: 406  NLSVEFAPVL 415
            +L+V  +P +
Sbjct: 2564 SLNVFVSPTI 2573



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 72/272 (26%), Positives = 110/272 (40%), Gaps = 13/272 (4%)

Query: 234 MDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVL----REAVAESLL 289
           + V+ PP +  M  +     GS VS++C A   P P + W  +   +    R  +     
Sbjct: 606 LTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGT 665

Query: 290 LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCST 349
           L ++   P + G+Y CLA N+ G D +   L  + AP    V   ++   G+   + C T
Sbjct: 666 LFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGDITVMECKT 725

Query: 350 QSNPDPILTIFKEKQIL--STVIYESEL--QLELPAVSPEDDGEYWCVAENQYGQRATAF 405
              P P +  FK    L  ST +    L   L++      D G+Y CVA N+ G+     
Sbjct: 726 SGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKI 785

Query: 406 NLSVEFAPVLLLESHCAAAR--DTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYS 463
            L V   PV + E    +      V   C V+  PEP++ +    R   +    R F  S
Sbjct: 786 TLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWR---RLDNMPIFSRPFSVS 842

Query: 464 ERSGLVLTSILTLRGQAQAPPRVICTARNLYG 495
             S L   ++  L   A      IC A N +G
Sbjct: 843 SISQLRTGALFILNLWASDKGTYICEAENQFG 874



 Score = 83.6 bits (205), Expect = 5e-16
 Identities = 99/409 (24%), Positives = 163/409 (39%), Gaps = 59/409 (14%)

Query: 59   WYFNSPYPKNYPPVVFKSRTQVVH-ESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYF 117
            WY ++        + F +R Q++  ES Q     + D G+  C  + S  + EL      
Sbjct: 1954 WYKDNRLLSGSTSMTFLNRGQIIDIESAQ-----ISDAGIYKCVAINSAGATELF----- 2003

Query: 118  RGDLGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGH 177
                     Y+   H    I  + N+V    VV    V + C      P   P L+WL  
Sbjct: 2004 ---------YSLQVHVAPSISGSNNMVA---VVVNNPVRLECEAR-GIPA--PSLTWL-K 2047

Query: 178  EGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVK 237
            +G    +    L+   G      +L     + ++  R  C A   N   + +    + V 
Sbjct: 2048 DGSPVSSFSNGLQVLSGG----RILALTSAQISDTGRYTCVAV--NAAGEKQRDIDLRVY 2101

Query: 238  YPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESL-----LLEL 292
             PP I+    +V  +    V LLC +D+ PPP LTW++DG  L +    S+     +L++
Sbjct: 2102 VPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKI 2161

Query: 293  EEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGT-----MVAVEGETVSILC 347
            E+    + G Y C A N  G+  +   +++ + P  P + G+     +  +EG  +S+LC
Sbjct: 2162 EDAQVQDTGRYTCEATNVAGKTEKNYNVNI-WVP--PNIGGSDELTQLTVIEGNLISLLC 2218

Query: 348  STQSNPDPILTIFKEK-------QILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQ 400
             +   P P L I+K+K        +    I     QL++      D   Y CVA N  G 
Sbjct: 2219 ESSGIPPPNL-IWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGT 2277

Query: 401  RATAFNLSVEFAPVLLLE-SH----CAAARDTVQCLCVVKSNPEPSVAF 444
                +NL V   P +    SH          ++   C V+  P P+V +
Sbjct: 2278 AKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTW 2326



 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 98/422 (23%), Positives = 163/422 (38%), Gaps = 55/422 (13%)

Query: 101  TLLLSNVSPELGGKYYFRGDLGGYNQYTFSEHSVLDIVNTPNIVVPPE---VVAGTEVEV 157
            TL + N +P+  G Y   G L   +  T  ++S L  +  P ++V      V  G    +
Sbjct: 665  TLFIKNAAPKDAGIY---GCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGDITVM 721

Query: 158  SCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVS----LLHFVPTREANGH 213
             C      P   P++ W            G L     T++ +     LL    T++ +  
Sbjct: 722  ECKTSGIPP---PQVKWFK----------GDLELRPSTFLIIDPLLGLLKIQETQDLDAG 768

Query: 214  RLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTW 273
               C A   N   +  G  ++DV  PPV ++  + V    GS+V+L C     P P + W
Sbjct: 769  DYTCVAI--NEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKW 826

Query: 274  MR--DGTVLREAVAESLLLELE-------EVTPAEDGVYACLAENAYG--QDNRTVGLSV 322
             R  +  +     + S + +L         +  ++ G Y C AEN +G  Q   TV ++ 
Sbjct: 827  RRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTG 886

Query: 323  MYAPWKPTVNGTMVAVEGETVSILCSTQS-NPDPILTIFKEKQILSTVIY---ESELQLE 378
            + AP           +EG+ +++ C+  + NP P     K   +L    Y    S+  L 
Sbjct: 887  LVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLH 946

Query: 379  LPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAAARDTVQCL-----CV 433
            +  V  +D GEY CVA N  G      ++ V   P +    H      T++ +     C 
Sbjct: 947  IERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTI---QHGQQILSTIEGIPVTLPCK 1003

Query: 434  VKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQAQAPPRVICTARNL 493
               NP+PSV +    +   ++ S  +F       L + S        +     +CTA N 
Sbjct: 1004 ASGNPKPSVIWS--KKGELISTSSAKFSAGADGSLYVVS-----PGGEESGEYVCTATNT 1056

Query: 494  YG 495
             G
Sbjct: 1057 AG 1058



 Score = 79.7 bits (195), Expect = 7e-15
 Identities = 59/223 (26%), Positives = 100/223 (44%), Gaps = 12/223 (5%)

Query: 231  YASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVL-----REAVA 285
            + ++ V  PPVI    S +  I  + + L C A   P P +TW ++G  +       AV 
Sbjct: 3979 HVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVL 4038

Query: 286  ESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAP-WKPTVNGTMVAVEGETVS 344
             S  L++      + G Y C+A+N  G     + L+V   P   P +   ++AV+ + ++
Sbjct: 4039 PSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVD-KPIT 4097

Query: 345  ILCSTQSNPDPILTIFKEKQILSTVIYESEL---QLELPAVSPEDDGEYWCVAENQYGQR 401
            + C     P P +T  K+ + +   I +  L    L++  V P D G Y C+A N  G  
Sbjct: 4098 LSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSS 4157

Query: 402  ATAFNLSVEFAP-VLLLESHCAAARDTVQCL-CVVKSNPEPSV 442
            +T+  L+V   P +   E H     ++   L CV    P P++
Sbjct: 4158 STSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAI 4200



 Score = 79.7 bits (195), Expect = 7e-15
 Identities = 66/238 (27%), Positives = 96/238 (40%), Gaps = 14/238 (5%)

Query: 234  MDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL---- 289
            + V  PP I          E S   L C AD  P P + W +D  +L   + +       
Sbjct: 4163 LTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYG 4222

Query: 290  -LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCS 348
             L LE V   + G Y C+A NA G+D  TV L+V   P    + G +   +GE + + C 
Sbjct: 4223 ELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCK 4282

Query: 349  TQSNPDPILTIFKEKQIL----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATA 404
                P P LT      I+     +V   SEL +E   VS ED G Y C AEN  G     
Sbjct: 4283 ATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIE--RVSKEDSGTYVCTAENSVGFVKAI 4340

Query: 405  FNLSVEFAPVL---LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESERE 459
              + V+  PV       +            C VK +P P++ +     ++ ++   R+
Sbjct: 4341 GFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQ 4398



 Score = 77.0 bits (188), Expect = 5e-14
 Identities = 100/397 (25%), Positives = 151/397 (38%), Gaps = 66/397 (16%)

Query: 93   GDLGLRNCTLLLSNVSPELGG-KYYFRGDL--GGYNQYTFSEHS------VLDIVNTPNI 143
            GDL LR  T L+  + P LG  K     DL  G Y     +E         LD+ + P  
Sbjct: 738  GDLELRPSTFLI--IDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVF 795

Query: 144  VVPPEVVA---GTEVEVSCMVP------------DNCPEL-RP-ELSWLGHEGLGEPAVL 186
            +  P  V+   G+ V + C V             DN P   RP  +S +     G   +L
Sbjct: 796  IQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFIL 855

Query: 187  GRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMN 246
                 D+GT++                   C+A      +Q E   ++     P+I    
Sbjct: 856  NLWASDKGTYI-------------------CEAENQFGKIQSETTVTVTGLVAPLIGISP 896

Query: 247  SSVEAIEGSHVSLLCGA-DSNPPPLLTWMRDGTVLRE----AVAESLLLELEEVTPAEDG 301
            S    IEG  ++L C     NP P   W+++  +L +     V     L +E V   + G
Sbjct: 897  SVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQLQDGG 956

Query: 302  VYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFK 361
             Y C+A N  G +N+T  + V   P        +  +EG  V++ C    NP P +   K
Sbjct: 957  EYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSK 1016

Query: 362  EKQILST--VIYESELQLELPAVSP--EDDGEYWCVAENQYGQRATAFNLSVEFAPVLLL 417
            + +++ST    + +     L  VSP  E+ GEY C A N  G       L+V   P +  
Sbjct: 1017 KGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFG 1076

Query: 418  ESH----------CAAARDTVQCLCVVKSNPEPSVAF 444
            +               A + V   C VKS P P + +
Sbjct: 1077 DQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITW 1113



 Score = 76.3 bits (186), Expect = 8e-14
 Identities = 94/408 (23%), Positives = 161/408 (39%), Gaps = 43/408 (10%)

Query: 120  DLGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPEL--------RPE 171
            D G Y     S     +I    +++VPP +  G E     ++ +N  EL         P 
Sbjct: 1706 DRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPT 1765

Query: 172  LSWLGHEGLGEPAVLGRLREDEGTWVQVS--LLHFVPTREANGHRLGCQASFPNTTLQFE 229
            + WL    L        + E +G  + ++   L     + +N     C A+  NT    +
Sbjct: 1766 IMWLKDGQL--------IDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAA--NTAGDHK 1815

Query: 230  GYASMDVKYPPVIVEMNSSVE-AIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA----- 283
                + V  PP I     S    ++   V+L C A+  P P +TW++D   +  A     
Sbjct: 1816 KEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLK 1875

Query: 284  -VAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTM--VAVEG 340
              +   +L++ +    + G Y C+A NA G+  + + L V   P        +    +  
Sbjct: 1876 IQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVS 1935

Query: 341  ETVSILCSTQSNPDPILTIFKEKQILS-----TVIYESELQLELPAVSPEDDGEYWCVAE 395
              V + C    NP P++T +K+ ++LS     T +   ++ +++ +    D G Y CVA 
Sbjct: 1936 NPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQI-IDIESAQISDAGIYKCVAI 1994

Query: 396  NQYGQRATAFNLSVEFAPVLLLESHCAA--ARDTVQCLCVVKSNPEPSVAFELPSRNVTV 453
            N  G     ++L V  AP +   ++  A    + V+  C  +  P PS+ + L   +   
Sbjct: 1995 NSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTW-LKDGSPVS 2053

Query: 454  NESEREFVYSERSGLVLTSILTLRGQAQAPPRVICTARNLYGAKSLEL 501
            + S    V S    L LTS      Q     R  C A N  G K  ++
Sbjct: 2054 SFSNGLQVLSGGRILALTS-----AQISDTGRYTCVAVNAAGEKQRDI 2096



 Score = 76.3 bits (186), Expect = 8e-14
 Identities = 63/260 (24%), Positives = 110/260 (42%), Gaps = 20/260 (7%)

Query: 201  LLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVE--AIEGSHVS 258
            +L    T   +  R  C A+  N   + + +  + V  PP + +    +    +  + V 
Sbjct: 1882 VLQIAKTLLEDAGRYTCVAT--NAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQ 1939

Query: 259  LLCGADSNPPPLLTWMRDGTVLREAVAESLL-----LELEEVTPAEDGVYACLAENAYGQ 313
            L C A  NP P++TW +D  +L  + + + L     +++E    ++ G+Y C+A N+ G 
Sbjct: 1940 LECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGA 1999

Query: 314  DNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYES 373
                  L V  AP     N  +  V    V + C  +  P P LT  K+   +S+  + +
Sbjct: 2000 TELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSS--FSN 2057

Query: 374  ELQ-------LELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAAA-- 424
             LQ       L L +    D G Y CVA N  G++    +L V   P ++ E    +   
Sbjct: 2058 GLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLI 2117

Query: 425  RDTVQCLCVVKSNPEPSVAF 444
               V+ LC   + P P++ +
Sbjct: 2118 SQAVELLCQSDAIPPPTLTW 2137



 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 78/339 (23%), Positives = 133/339 (39%), Gaps = 51/339 (15%)

Query: 142  NIVVPPEVVAGTEVEVSCMVPDNCPELR--------PELSWLGHEGLGEPAVLGRLREDE 193
            N+ VPP +  G E EV      N   L         P ++WL +          R+   +
Sbjct: 3146 NVYVPPSI-EGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHK--------RIENSD 3196

Query: 194  GTWVQV----SLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIV--EMNS 247
               V++    S L    ++ ++     C AS  N   + + Y  + ++ PP +   E+ S
Sbjct: 3197 SLEVRILSGGSKLQIARSQHSDSGNYTCIAS--NMEGKAQKYYFLSIQVPPSVAGAEIPS 3254

Query: 248  SVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESL-------LLELEEVTPAED 300
             V  + G +V L+C A+  P PL+ W++DG  +     E +        L +     ++ 
Sbjct: 3255 DVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDT 3314

Query: 301  GVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGT------MVAVEGETVSILCSTQSNPD 354
            G Y C+A N  G+++R   L+V      PT+ G       ++ +   +++I C     P 
Sbjct: 3315 GKYTCVATNPAGEEDRIFNLNVYVT---PTIRGNKDEAEKLMTLVDTSINIECRATGTPP 3371

Query: 355  PILTIFKEKQILSTVIYESELQ----LELPAVSPEDDGEYWCVAENQYGQRATAFNLSVE 410
            P +   K    L    +   L     + +      D   Y CVA N+ G     +NL V 
Sbjct: 3372 PQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQV- 3430

Query: 411  FAPVLL-----LESHCAAARDTVQCLCVVKSNPEPSVAF 444
            FAP  +      E        +    C+    P PS+A+
Sbjct: 3431 FAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAW 3469



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 59/226 (26%), Positives = 96/226 (42%), Gaps = 22/226 (9%)

Query: 249  VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVL-----REAVAESLLLELEEVTPAEDGVY 303
            +  + G  V+L C   S PPP++TW ++  ++     R     S  +++ E   ++ G+Y
Sbjct: 1089 ISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMY 1148

Query: 304  ACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEK 363
             C+A N  G   + V L+V   P        +    G+ V I C+ Q  P P++T  K  
Sbjct: 1149 LCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGG 1208

Query: 364  QILSTVIYESELQ-------LELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL 416
               ST++ + E         L +   +P D G Y CVA N  G   T   L V+  P + 
Sbjct: 1209 ---STMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVE 1265

Query: 417  -LES------HCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNE 455
             LE           A   ++  C  K  P+P++ +    R +T  E
Sbjct: 1266 DLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGRE 1311



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 73/330 (22%), Positives = 138/330 (41%), Gaps = 44/330 (13%)

Query: 202  LHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMN--------SSVEAIE 253
            L  +  +E N  R  C A+  N   +   +  + V  PP+I + +          V+   
Sbjct: 2631 LQILNAQEDNAGRYSCVAT--NEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKV 2688

Query: 254  GSHVSLLCGADSNPPPLLTWMRDGTVLRE-----AVAESLLLELEEVTPAEDGVYACLAE 308
             + ++L C A + P   L+W +DG  L+        A    L+++E   ++ G Y C+A 
Sbjct: 2689 NNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVAS 2748

Query: 309  NAYGQDNRTVGLSVMYAP--WKPTVNGTMV----------AVEGETVSILCSTQSNPDPI 356
            N  G+D     +++   P   K    G M+           +    +S+ C T + P P 
Sbjct: 2749 NIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPT 2808

Query: 357  LTIFKEKQILST----VIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFA 412
            LT +K+   L++    +I      L++P    ED G Y CVA N+ G+ +  +++ V   
Sbjct: 2809 LTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVP 2868

Query: 413  PVL------LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERS 466
            P++      L E        +    C+   +P P  +++   + + + +   +F+ + R 
Sbjct: 2869 PIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPL-LEDDHHKFLSNGRI 2927

Query: 467  GLVLTSILTLRGQAQAPPRVICTARNLYGA 496
              +L + +T  G      R +C A N  G+
Sbjct: 2928 LQILNTQITDIG------RYVCVAENTAGS 2951



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 61/235 (25%), Positives = 93/235 (39%), Gaps = 29/235 (12%)

Query: 233  SMDVKYPPVIVEMNSSV-----EAIEGSHVSLLCGADSNPPPLLTWMRDGTVLR------ 281
            ++ V+ PP + ++         E +    +   C A   P P + W+ +G  L       
Sbjct: 1255 TLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGI 1314

Query: 282  EAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPW---KPTVNGTMVAV 338
              + +  LL +  VTP ++G Y C+A N  G   R   L V   P    K  V    V +
Sbjct: 1315 SILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLL 1374

Query: 339  EGETVSILCSTQSNPDPILTIFK------EKQILSTVIYESELQLELPAVSPEDDGEYWC 392
              +  ++ C  +  P PI+  +K      E   + TV   +   L+L   +PED G Y C
Sbjct: 1375 N-QLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTV--NNGKILKLFRATPEDAGRYSC 1431

Query: 393  VAENQYGQRATAFNLSVEFAPVLL-----LESHCAAARDTVQCLCVVKSNPEPSV 442
             A N  G     FN+ V   P ++      E      RD V   C VK  P P +
Sbjct: 1432 KAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRD-VALECQVKGTPFPDI 1485



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 63/280 (22%), Positives = 114/280 (40%), Gaps = 19/280 (6%)

Query: 233  SMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLR---EAVAESLL 289
            S+ V   P   E+   V   +G  + L C A   P P LTW  +  ++    ++V     
Sbjct: 4253 SLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSE 4312

Query: 290  LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAP--WKPTVNGTMVAVEGETVSILC 347
            L +E V+  + G Y C AEN+ G   + +G   +  P  +K       +   G    + C
Sbjct: 4313 LVIERVSKEDSGTYVCTAENSVGFV-KAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNC 4371

Query: 348  STQSNPDPILTIFKEK---QILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATA 404
              + +P P +   ++    +I   +       L +     ED G+Y CVA N+ G    +
Sbjct: 4372 EVKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERS 4431

Query: 405  FNLSVEFAPVLLLE--SHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVY 462
             +L+++  P++ LE       A   +   C     P+P++ +     +++ +  +R  V 
Sbjct: 4432 MSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWD--DRVNVL 4489

Query: 463  SERSGLVLTSILTLRGQAQAPPRVICTARNLYGAKSLELP 502
            S        S+     Q +      C ARNL G+  + +P
Sbjct: 4490 SN------NSLYIADAQKEDTSEFECVARNLMGSVLVRVP 4523



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 69/285 (24%), Positives = 115/285 (40%), Gaps = 34/285 (11%)

Query: 148  EVVAGTEVEVSCMVPDNCPELRPELSWL--GHEGLGEPAVLGRLREDEGTWVQVSLLHFV 205
            E VA   +E  C         +P + WL  G E  G    +  L  ++GT + ++ +   
Sbjct: 1277 ERVANQRIEFPCPAKGTP---KPTIKWLHNGRELTGREPGISIL--EDGTLLVIASV--- 1328

Query: 206  PTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIV--EMNSSVEAIEGSHVSLLCGA 263
             T   NG  +    +   TT   E   ++ V  PPVI   E  ++V  +     +L C  
Sbjct: 1329 -TPYDNGEYICVAVNEAGTT---ERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEV 1384

Query: 264  DSNPPPLLTWMRDGTVLREA-----VAESLLLELEEVTPAEDGVYACLAENAYGQDNRTV 318
            +  P P++ W +D   + E+     V    +L+L   TP + G Y+C A N  G   +  
Sbjct: 1385 EGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYF 1444

Query: 319  GLSVMYAPWKPTVNGT-----MVAVEGETVSILCSTQSNPDPILTIFKEKQIL-----ST 368
             + V+  P   T+ GT     +  V    V++ C  +  P P +  FK+ + L     + 
Sbjct: 1445 NIDVLVPP---TIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNV 1501

Query: 369  VIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAP 413
             + +    L L      D G Y C   N  G++A    L++   P
Sbjct: 1502 ELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPP 1546



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 78/309 (25%), Positives = 130/309 (42%), Gaps = 52/309 (16%)

Query: 142  NIVVPPEVVAGTEVE-----------VSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLR 190
            +++VPP +V    +E           ++C V  N     PE++W  H+  G+P     L+
Sbjct: 2473 SVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPV---PEITW--HKD-GQP-----LQ 2521

Query: 191  EDEGTWVQVS--LLHFVPTREANGHRLGCQASFP--NTTLQFEGYASMDVKYPPVIVEMN 246
            EDE   +      L     +  +  R  C AS P  + +  F    S++V   P I  + 
Sbjct: 2522 EDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSF----SLNVFVSPTIAGVG 2577

Query: 247  SS-----VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-----LELEEVT 296
            S      V  I  S  SL+C A S PP  +TW +DGT L       +L     L++    
Sbjct: 2578 SDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQ 2637

Query: 297  PAEDGVYACLAENAYGQDNRTVGLSVMYAP-------WKPTVNGTMVAVE-GETVSILCS 348
                G Y+C+A N  G+  +   + V   P       W P ++   V ++   T+++ C 
Sbjct: 2638 EDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECE 2697

Query: 349  TQSNPDPILTIFKEKQILST----VIYESELQLELPAVSPEDDGEYWCVAENQYGQRATA 404
              + P   L+ +K+ Q L +     I  +   L++      D G Y CVA N  G+    
Sbjct: 2698 AYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELD 2757

Query: 405  FNLSVEFAP 413
            F+++++  P
Sbjct: 2758 FDVNIQVPP 2766



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 79/363 (21%), Positives = 146/363 (40%), Gaps = 33/363 (9%)

Query: 130  SEHSVLDIVNTPNIVVPPE-----VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPA 184
            S+H +L ++  P+I    E     V+    +E++C +    P   P+++W+  +G   P 
Sbjct: 3516 SKHFILKVLEPPHINGSEEHEEISVIVNNPLELTC-IASGIPA--PKMTWM-KDGRPLPQ 3571

Query: 185  VLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVE 244
                     G  +++S      T      R  C AS P      E    + V  PP I  
Sbjct: 3572 TDQVQTLGGGEVLRISTAQVEDTG-----RYTCLASSPAGDDDKEYLVRVHV--PPNIAG 3624

Query: 245  MNS--SVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-----LELEEVTP 297
             +    +  +    V+L C +D+ PPP++TW+R+G  L+      +L     L++     
Sbjct: 3625 TDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRILSGGRYLQINNADL 3684

Query: 298  AEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPIL 357
             +   Y C+A N  G+  R   L+V   P       ++V +  ++  + C  +  P P +
Sbjct: 3685 GDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRI 3744

Query: 358  TIFKEKQILS------TVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEF 411
            T  K+  +L+      +++    L ++   V+  D G Y C+A N  G      +L V  
Sbjct: 3745 TWRKDGAVLAGNHARYSILENGFLHIQSAHVT--DTGRYLCMATNAAGTDRRRIDLQVHV 3802

Query: 412  APVLLLESHCAAARDTVQ--CLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLV 469
             P +            VQ    C     P+PS+ +      + V++++  +       LV
Sbjct: 3803 PPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLV 3862

Query: 470  LTS 472
            + S
Sbjct: 3863 IIS 3865



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 54/221 (24%), Positives = 93/221 (42%), Gaps = 16/221 (7%)

Query: 250  EAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-----LELEEVTPAEDGVYA 304
            + I  + +SL C  ++ PPP LTW +DG  L  +    +L     L++      + G Y 
Sbjct: 2788 DVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYT 2847

Query: 305  CLAENAYGQDNRTVGLSVMYAPWKPTVNGTM----VAVEGETVSILCSTQSNPDPILTIF 360
            C+A N  G+D+    + V+  P     N  +      +  ++  I C +  +P P  +  
Sbjct: 2848 CVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQ 2907

Query: 361  KEKQILSTVIYESELQ----LELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL 416
            K+ Q L    +   L     L++      D G Y CVAEN  G     FNL+V   P ++
Sbjct: 2908 KDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVI 2967

Query: 417  ---LESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVN 454
                E+      + +   C V   P P +++    + + +N
Sbjct: 2968 GPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLN 3008



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 56/227 (24%), Positives = 87/227 (38%), Gaps = 23/227 (10%)

Query: 234  MDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVL-----REAVAESL 288
            + V  PP I     S+  +      L C A+  P P +TW +DG VL     R ++ E+ 
Sbjct: 3707 LTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENG 3766

Query: 289  LLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCS 348
             L ++     + G Y C+A NA G D R + L V   P        M  +     ++ C 
Sbjct: 3767 FLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACE 3826

Query: 349  TQSNPDPILTIFKEKQILSTVIYESELQL----ELPAVSP--EDDGEYWCVAENQYGQRA 402
                P P +   K   +L+    ++  +L     L  +SP  +D   Y C   N  G   
Sbjct: 3827 ATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDK 3886

Query: 403  TAFNLSVEFAPVL-------LLESHCAAARDTVQCLCVVKSNPEPSV 442
               +L+V+  P +       L+  H  A        C     P PS+
Sbjct: 3887 RTVDLTVQVPPSIADEPTDFLVTKHAPAV-----ITCTASGVPFPSI 3928



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 84/382 (21%), Positives = 144/382 (37%), Gaps = 47/382 (12%)

Query: 143  IVVPPEVVAGT-----EVEVSCMVPDNCPELR----PELSWLGHEGLGEPAVLGR--LRE 191
            I +PP +  G       V ++ ++   C E R    P ++W      G+P +     L  
Sbjct: 1542 IYIPPSIKGGNVTTDISVLINSLIKLEC-ETRGLPMPAITWYKD---GQPIMSSSQALYI 1597

Query: 192  DEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSV-- 249
            D+G +     LH    + ++     C  +  N     E    +DV  PP+I E N +   
Sbjct: 1598 DKGQY-----LHIPRAQVSDSATYTCHVA--NVAGTAEKSFHVDVYVPPMI-EGNLATPL 1649

Query: 250  --EAIEGSHVSLLCGADSNPPPLLTWMRDGTVLR-----EAVAESLLLELEEVTPAEDGV 302
              + +    ++L C A  NP P+LTW++DG  ++        A    LE+      + G 
Sbjct: 1650 NKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQ 1709

Query: 303  YACLAENAYGQDNRTVGLSVMYAPWKPTVNGT--MVAVEGETVSILCSTQSNPDPILTIF 360
            Y C+A +  G+      + V+  P     + T   + +    + + C    +P P +   
Sbjct: 1710 YICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWL 1769

Query: 361  KEKQILST----VIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL 416
            K+ Q++       I  +  +L +      + G Y C+A N  G     F ++V   P + 
Sbjct: 1770 KDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIK 1829

Query: 417  ---LESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSI 473
               L          V   C+    P PS+ +    + V   +   +    + SG VL   
Sbjct: 1830 SSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKI---QSSGRVLQIA 1886

Query: 474  LTLRGQAQAPPRVICTARNLYG 495
             TL   A    R  C A N  G
Sbjct: 1887 KTLLEDA---GRYTCVATNAAG 1905



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 59/219 (26%), Positives = 86/219 (39%), Gaps = 11/219 (5%)

Query: 235 DVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA------VAESL 288
           DV  PP ++++ ++V    G    L C   S     LTW R+   +R A         +L
Sbjct: 515 DVSEPPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANL 574

Query: 289 LLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCS 348
            LEL+ V   + G Y C+  +  G    +V L+V   P    +        G  VSI+CS
Sbjct: 575 SLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCS 634

Query: 349 TQSNPDP-ILTIFKEKQILSTVIYE--SELQLELPAVSPEDDGEYWCVAENQYGQRATAF 405
               P P I     +  I+ +  Y   S+  L +   +P+D G Y C+A N  G      
Sbjct: 635 ATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNS 694

Query: 406 NLSVEFAPVLLL--ESHCAAARDTVQCLCVVKSNPEPSV 442
            L    AP L++       A  D     C     P P V
Sbjct: 695 TLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQV 733



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 42/179 (23%), Positives = 72/179 (40%), Gaps = 17/179 (9%)

Query: 249  VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVL-----REAVAESLLLELEEVTPAEDGVY 303
            +  ++GS  S+ C  D  P P + W+RDG  L            ++L+L +    + G Y
Sbjct: 3445 ITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKY 3504

Query: 304  ACLAENAYGQDNRTVGLSVMYAPWKPTVNGT-----MVAVEGETVSILCSTQSNPDPILT 358
             C+A N  G+ ++   L V+     P +NG+     +  +    + + C     P P +T
Sbjct: 3505 TCIASNEAGEVSKHFILKVLE---PPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMT 3561

Query: 359  IFKEKQILSTVIYESEL----QLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAP 413
              K+ + L        L     L +     ED G Y C+A +  G     + + V   P
Sbjct: 3562 WMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPP 3620



 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 47/195 (24%), Positives = 85/195 (43%), Gaps = 11/195 (5%)

Query: 261 CGADSNPPPLLTWMRDGTVLRE----AVAESLLLELEEVTPAEDGVYACLAENAYGQDNR 316
           C  DS  P  L+++R+G  L        + S+ L++ +VT +++G Y C+A ++ G    
Sbjct: 451 CSVDSLLPFTLSFVRNGVTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRA 510

Query: 317 TVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQIL-----STVIY 371
                V   P    V   +    GE   + C   S  D  LT  +  + +     + +  
Sbjct: 511 QTFFDVSEPPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRT 570

Query: 372 ESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAP--VLLLESHCAAARDTVQ 429
            + L LEL +V   D GEY C+  ++ G  A +  L+V+  P   ++ ++        V 
Sbjct: 571 LANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVS 630

Query: 430 CLCVVKSNPEPSVAF 444
            +C     P+P +A+
Sbjct: 631 IMCSATGYPKPKIAW 645



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 63/276 (22%), Positives = 96/276 (34%), Gaps = 22/276 (7%)

Query: 234  MDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELE 293
            + V  PP I    +++  I     +L C A   P P + W ++G +L     ++    L 
Sbjct: 3798 LQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLS 3857

Query: 294  E-----VTPAED--GVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSIL 346
                  ++P+ D    Y C   N  G D RTV L+V   P         +  +     I 
Sbjct: 3858 SGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVIT 3917

Query: 347  CSTQSNPDPILTIFKEKQIL----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRA 402
            C+    P P +   K    L          S   +E+ A      G Y CVA N  G   
Sbjct: 3918 CTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAH 3977

Query: 403  TAFNLSVEFAPVLL---LESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESERE 459
                L V   PV+     E H     + +   C     P P + ++     + VN S R 
Sbjct: 3978 RHVTLHVHEPPVIQPQPSELH-VILNNPILLPCEATGTPSPFITWQ--KEGINVNTSGRN 4034

Query: 460  FVYSERSGLVLTSILTLRGQAQAPPRVICTARNLYG 495
                   GL ++     R   +     +C A+N  G
Sbjct: 4035 HAVLPSGGLQIS-----RAVREDAGTYMCVAQNPAG 4065


>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3874

 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 93/353 (26%), Positives = 155/353 (43%), Gaps = 33/353 (9%)

Query: 131  EHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLR 190
            +H  L +  +P +   P VV     E   +  +     RP ++W   EGL     +    
Sbjct: 2747 KHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQ-KEGLNVATGVSTQV 2805

Query: 191  EDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVE 250
               G   Q+ + H  P  E  G+ L C A   N+     G   + V+ PPVI      + 
Sbjct: 2806 LPGG---QLRIAHASP--EDAGNYL-CIAK--NSAGSAMGKTRLVVQVPPVIENGLPDLS 2857

Query: 251  AIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-----VAESLLLELEEVTPAEDGVYAC 305
              EGSH  L C A  +P P +TW +DG  +  A     +  S  L ++ +   + G Y C
Sbjct: 2858 TTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTC 2917

Query: 306  LAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQI 365
             AENA G+  R V L+++  P   T+ G      G+ + + C+ + +P P +      + 
Sbjct: 2918 TAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRP 2977

Query: 366  LSTVIYESE--LQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAA 423
            ++  + E +    L+  AVS ED G Y C AEN+ G+      + V+ APVL  E+    
Sbjct: 2978 VTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYL 3037

Query: 424  AR---DTVQCLCVVKSNPEPSVAF--------------ELPSRNVTVNESERE 459
                  ++Q  CVV+ +P P + +              +L + ++T++ +ER+
Sbjct: 3038 VEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERD 3090



 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 93/329 (28%), Positives = 138/329 (41%), Gaps = 35/329 (10%)

Query: 143  IVVPPEVVAGTE-------VEVSCMVPDNCPELR---PELSWLGHEGLGEPAVLGRLRED 192
            ++ PP ++  TE       V  S  V   CP L    P +SWL +     P+   ++ ED
Sbjct: 1647 VLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLED 1706

Query: 193  EGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMN-SSVEA 251
             G  +QVS         A+     C A   N     E   ++ V+ PP I  ++   V A
Sbjct: 1707 -GQVLQVSTAEV-----ADAASYMCVAE--NQAGSAEKLFTLRVQVPPRIAGLDLEQVTA 1758

Query: 252  IEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-----LELEEVTPAEDGVYACL 306
            I  S VSL C   ++P P +TW +D   L       LL     L+L     ++ G+Y C 
Sbjct: 1759 ILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCE 1818

Query: 307  AENAYGQDNRTVGLSVMYAP-WKPTVNGTMVAV---EGETVSILCSTQSNPDPILTIFKE 362
            A NA G+D + V LSV+  P ++    G   AV    G+   + C T + P+P +T +K+
Sbjct: 1819 ALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKD 1878

Query: 363  KQIL----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL--- 415
             Q L     T       +LE+      D G Y C   N  G+    F L+V+  P     
Sbjct: 1879 GQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENP 1938

Query: 416  LLESHCAAARDTVQCLCVVKSNPEPSVAF 444
              E+    A   +   C V   P P+V +
Sbjct: 1939 KTETVSQVAGSPLVLTCDVSGVPAPTVTW 1967



 Score = 83.2 bits (204), Expect = 7e-16
 Identities = 70/270 (25%), Positives = 112/270 (41%), Gaps = 17/270 (6%)

Query: 236  VKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-----VAESLLL 290
            V  PP I +  +       + V L C +   P P ++W + G  L        V+ S  L
Sbjct: 2662 VHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGAL 2721

Query: 291  ELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQ 350
            E+ +  P   G Y C A N+ G  ++ V L+V  +P    +   + AV  E V + C   
Sbjct: 2722 EIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEAS 2781

Query: 351  SNPDPILTIFKEKQILSTVIYESEL---QLELPAVSPEDDGEYWCVAENQYGQRATAFNL 407
              P P +T  KE   ++T +    L   QL +   SPED G Y C+A+N  G       L
Sbjct: 2782 GIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRL 2841

Query: 408  SVEFAPVLL--LESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSER 465
             V+  PV+   L              C  + +PEP++ ++   +   V+ +E +F     
Sbjct: 2842 VVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQ--PVSGAEGKFTIQPS 2899

Query: 466  SGLVLTSILTLRGQAQAPPRVICTARNLYG 495
              L++ ++     + Q      CTA N  G
Sbjct: 2900 GELLVKNL-----EGQDAGTYTCTAENAVG 2924



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 93/419 (22%), Positives = 163/419 (38%), Gaps = 51/419 (12%)

Query: 142  NIVVPPEVVAGTEVEVSCMVPDNCPELR---------PELSWLGHEGLGEPAVLGRLRED 192
            +++VPPE++   +   +     + P            P + W   E   EP   G   ED
Sbjct: 1154 SVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGE---EPVSPG---ED 1207

Query: 193  EGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIV--EMNSSVE 250
                    +L    T+E +     C AS  N   +     S++V  PP I   ++   ++
Sbjct: 1208 TYLLAGGWMLKMTQTQEQDSGLYSCLAS--NEAGEARRNFSVEVLVPPSIENEDLEEVIK 1265

Query: 251  AIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVA-----ESLLLELEEVTPAEDGVYAC 305
             ++G    L+C    +P P LTW +DG  L    A     + +LL++ +   +  G Y+C
Sbjct: 1266 VLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSC 1325

Query: 306  LAENAYGQDNRTVGLSVMYAPW-----KPTVNGTMVAVEGETVSILCSTQSNPDPILTIF 360
            +A NA G+  +   LSV+ AP      + + +  +       +S++C   + P P +T  
Sbjct: 1326 IAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWM 1385

Query: 361  KE----KQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL 416
            K+    +   +  +      L++     ED G+Y CV  N+ G+    +++ V   P + 
Sbjct: 1386 KDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSIS 1445

Query: 417  LESHC---------AAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSG 467
             +                 T+   C   + P P++ +    + VT   S R  V  E   
Sbjct: 1446 KDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVT--PSSRLQVLGEGRL 1503

Query: 468  LVLTSILTLRGQAQAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAIL 526
            L +        Q     R +C A N+ G    +         M+ K+G   A  AF IL
Sbjct: 1504 LQIQPT-----QVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSA--AFEIL 1555



 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 70/286 (24%), Positives = 117/286 (40%), Gaps = 30/286 (10%)

Query: 234  MDVKYPPVIV---EMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL- 289
            ++V  PP I    E  + V  ++    +L C A   PPP +TW RDG  +   +   L  
Sbjct: 1059 LEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQN 1118

Query: 290  ----LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAP-----WKPTVNGTMVAVEG 340
                L +E    A  G Y+C+AEN  G+  R   LSV+  P       P  N  + A   
Sbjct: 1119 QGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTN--ITAALH 1176

Query: 341  ETVSILCSTQSNPDPILTIFKEKQILS----TVIYESELQLELPAVSPEDDGEYWCVAEN 396
              +++LC     P P +  F+ ++ +S    T +      L++     +D G Y C+A N
Sbjct: 1177 SPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASN 1236

Query: 397  QYGQRATAFNLSVEFAPVL----LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVT 452
            + G+    F++ V   P +    L E        T   +C V  +P+P + +    R + 
Sbjct: 1237 EAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLA 1296

Query: 453  VNESEREFVYSERSGLVLTSILTLRGQAQAPPRVICTARNLYGAKS 498
              ++     +    G++L     L+    +     C A N  G K+
Sbjct: 1297 RGDAH----HISPDGVLLQ---VLQANLSSAGHYSCIAANAVGEKT 1335



 Score = 80.1 bits (196), Expect = 6e-15
 Identities = 87/368 (23%), Positives = 153/368 (41%), Gaps = 42/368 (11%)

Query: 149  VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSL----LHF 204
            V+ G EV + C      P   P+++WL     G P     L +D G  ++  L    L  
Sbjct: 2038 VLEGQEVRLDCEADGQPP---PDVAWLKD---GSP-----LGQDMGPHLRFYLDGGSLVL 2086

Query: 205  VPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVI---VEMNSSVEAIEGSHVSLLC 261
               R ++     C A   N   +     +++V  PP I    + + ++ +  G  V+++C
Sbjct: 2087 KGLRASDAGAYTCVAH--NPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVC 2144

Query: 262  GADSNPPPLLTWMRDGTVLREAVAESL-----LLELEEVTPAEDGVYACLAENAYGQDNR 316
                +PP  ++W++DG  L  +    L      L + +V  A+ G++ C+A +  G  +R
Sbjct: 2145 PVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADR 2204

Query: 317  TVGLSVMYAPWKPTVN--GTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESE 374
               L V   P    V     +V V G  V + C  +  P P+++  K+ + L +   E  
Sbjct: 2205 NFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQG 2264

Query: 375  LQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAAARDT----VQC 430
              L+L AV   D G Y CVA ++ G+    F L+V   P +           T    ++ 
Sbjct: 2265 PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMEL 2324

Query: 431  LCVVKSNPEPSVAFELPSRNVT--VNESEREFVYSERSGLVLTSIL---------TLRGQ 479
            LC  +  P+P++ +    + +T   N S    V   R   + T +          + R +
Sbjct: 2325 LCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVR 2384

Query: 480  AQAPPRVI 487
             QAPP ++
Sbjct: 2385 VQAPPNIV 2392



 Score = 79.7 bits (195), Expect = 7e-15
 Identities = 60/225 (26%), Positives = 96/225 (42%), Gaps = 35/225 (15%)

Query: 255  SHVSLLCGADSNPPPLLTWMRDGTVLR-----EAVAESLLLELEEVTPAEDGVYACLAEN 309
            S ++L C + + PPP + W +DG  +      + + E  LL+++    ++ G Y C+A N
Sbjct: 1464 STLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATN 1523

Query: 310  AYGQDNRTVGLSVMYAPWKPTVNGTMVA--------------------VEGETVSILCST 349
              G+D++   + +   P    V     A                    VE     + C T
Sbjct: 1524 VAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDT 1583

Query: 350  QSNPDPILTIFKEKQILSTVIYESELQ----LELPAVSPEDDGEYWCVAENQYGQRATAF 405
             + P P LT ++E Q LS     S LQ    L++P V  E+ G Y C A N+ G+    +
Sbjct: 1584 NAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHY 1643

Query: 406  NLSVEFAPVL------LLESHCAAARDTVQCLCVVKSNPEPSVAF 444
             L V   PV+      L+E     A  TV   C    NP P++++
Sbjct: 1644 ELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISW 1688



 Score = 77.0 bits (188), Expect = 5e-14
 Identities = 94/383 (24%), Positives = 143/383 (37%), Gaps = 51/383 (13%)

Query: 141  PNIVVPPE----VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTW 196
            P I +PP     V+  T V ++C      P   P L WL       PA    L+   G  
Sbjct: 786  PRITLPPSLPGPVLVNTPVRLTCNAT-GAPS--PTLMWLKDGNPVSPAGTPGLQVFPGGR 842

Query: 197  VQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSH 256
            V    L     R ++  R  C A   +   +      + V  PP I+    +V  +    
Sbjct: 843  V----LTLASARASDSGRYSCVAV--SAVGEDRQDVVLQVHMPPSILGEELNVSVVANES 896

Query: 257  VSLLCGADSNPPPLLTWMRDGTVLR-----EAVAESLLLELEEVTPAEDGVYACLAENAY 311
            V+L C + + PPP+L+W +DG  L         A+  LL+++     + G Y C A N  
Sbjct: 897  VALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQA 956

Query: 312  GQDNRTVGLSVMYAPWKP-TVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQIL---- 366
            G+  +   L+V  AP  P   + T+   EG   S+ C  +  P P ++  K+ Q L    
Sbjct: 957  GRSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEG 1016

Query: 367  ---------STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL- 416
                       ++Y  + QL         +G Y C   N  G  +    L V   P +  
Sbjct: 1017 AGLQHVSAVGRLLYLGQAQL-------AQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAG 1069

Query: 417  ---LESHCAAARDTVQCL-CVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTS 472
                 +  +  +D V  L C     P P+V +E   + V         +  +  G    S
Sbjct: 1070 PREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELG----LQLQNQG---QS 1122

Query: 473  ILTLRGQAQAPPRVICTARNLYG 495
            +   R QA    R  C A NL G
Sbjct: 1123 LHVERAQAAHTGRYSCVAENLAG 1145



 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 86/332 (25%), Positives = 125/332 (37%), Gaps = 38/332 (11%)

Query: 172 LSWLGHE-GLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTL---- 226
           L W G+   LG   V G    DEG       LHF   +     R G QA     T     
Sbjct: 141 LGWAGYGWDLGWGQVGGHRLLDEG-----QSLHFPRIQPGRSGRRGAQAGGSAQTKAPWX 195

Query: 227 -------QFEGYASMDVKYPPVIVEMNSSVEAI--EGSHVSLLCGADSNPPPLLTWMRD- 276
                  QF    +     PP ++   ++ E +   G+ V L C     P P + W +D 
Sbjct: 196 AGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDR 255

Query: 277 -----GTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAP--WKP 329
                G    +   +  +L +      ++G Y C+A +  GQ  R   L V   P  W  
Sbjct: 256 QPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGS 315

Query: 330 TVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILST---VIY-ESELQLELPAVSPE 385
              G +  +E   V +LC  +  P P +T FK+  +L T   V+Y     QL+L      
Sbjct: 316 NETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSS 375

Query: 386 DDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESH-----CAAARDTVQCLCVVKSNPEP 440
           D G Y C A N  G    A  L V   P +           A A   V   CV + +P P
Sbjct: 376 DAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSP 435

Query: 441 SVAFELPSRNVTVNESEREFVYSERSGLVLTS 472
           ++++      + V ES    + ++ S L L S
Sbjct: 436 TLSWH--HEGLPVAESNESRLETDGSVLRLES 465



 Score = 72.8 bits (177), Expect = 9e-13
 Identities = 63/224 (28%), Positives = 92/224 (41%), Gaps = 20/224 (8%)

Query: 250  EAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-----LELEEVTPAEDGVYA 304
            E +E +   L C  ++ PPP LTW R+   L      S+L     L++  V     G Y+
Sbjct: 1570 EIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYS 1629

Query: 305  CLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVE------GETVSILCSTQSNPDPILT 358
            C A N  G+D     L V+  P    +  T   VE        TVS+ C    NP P ++
Sbjct: 1630 CKASNEVGEDWLHYELLVLTPP--VILGDTEELVEEVTVNASSTVSLQCPALGNPVPTIS 1687

Query: 359  IFKEKQILS----TVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPV 414
              +     S      + E    L++      D   Y CVAENQ G     F L V+  P 
Sbjct: 1688 WLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPR 1747

Query: 415  LL---LESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNE 455
            +    LE   A    +V   C V ++P P V +   S+ +++ E
Sbjct: 1748 IAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGE 1791



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 63/229 (27%), Positives = 97/229 (42%), Gaps = 26/229 (11%)

Query: 236 VKYPPVIVEMNSS--VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-----VAESL 288
           V  PP I   N +  V  +E   V LLC A   P P +TW +DG +L  +          
Sbjct: 306 VHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGR 365

Query: 289 LLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNG------TMVAVEGET 342
            L+L     ++ GVY C A NA G   +   L V Y P  PT+ G       + AV G  
Sbjct: 366 QLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV-YVP--PTIEGAGGRPYVVKAVAGRP 422

Query: 343 VSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGE-----YWCVAENQ 397
           V++ C  + +P P L+ +  + +      ES L+ +   +  E  GE     Y CVA + 
Sbjct: 423 VALECVARGHPSPTLS-WHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSP 481

Query: 398 YGQRATAFNLSVEFAPVLLLESHCAAARDTV----QCLCVVKSNPEPSV 442
            G+    +++ V+  P LL+          V    +  C    +P P++
Sbjct: 482 AGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTI 530



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 95/381 (24%), Positives = 143/381 (37%), Gaps = 53/381 (13%)

Query: 134  VLDIVNTPNIVVPPEVVAGTEVEVSCM---VPDNCPELRPELSWLGHEGLGEPAVLGRLR 190
            VL+ V   N VV   VV G+ VE+ C    VP       P +SW+     GEP +   L 
Sbjct: 2215 VLEPVEFQNDVV---VVRGSLVELPCEARGVP------LPLVSWMKD---GEPLLSQSLE 2262

Query: 191  EDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYA----SMDVKYPPVIVEMN 246
            +              P+ +      G   ++    +   G A     + V  PP I +  
Sbjct: 2263 QG-------------PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSG 2309

Query: 247  SSVEA--IEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDGVYA 304
               E     G+ + LLC A   P P +TW +DG  L      S    +  V  A  G+Y 
Sbjct: 2310 QPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDA--GLYT 2367

Query: 305  CLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAV---EGETVSILCSTQSNPDPILTIFK 361
            CLAE+  G   ++  + V   P      G    V    G+ V + CS ++ P P +T  +
Sbjct: 2368 CLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLV-LECSVEAEPAPKITWHR 2426

Query: 362  EKQILS----TVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLL 417
            +  +L     T   E    L+L A+S  D G+Y C A N  G  + AF + +   P +  
Sbjct: 2427 DGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRS 2486

Query: 418  ESHC--AAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILT 475
                   +   T    C     P P V++      V ++     F       L +  +L 
Sbjct: 2487 GPPAVNVSVNQTALLPCQADGVPAPLVSWR--KDRVPLDPRSPRFEILPEGSLRIQPVL- 2543

Query: 476  LRGQAQAPPRVICTARNLYGA 496
                AQ     +C A N  G+
Sbjct: 2544 ----AQDAGHYLCLASNSAGS 2560



 Score = 69.7 bits (169), Expect = 8e-12
 Identities = 50/200 (25%), Positives = 86/200 (43%), Gaps = 20/200 (10%)

Query: 233  SMDVKYPPVIVEMNS-SVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-- 289
            ++ V+ PP      + +V  + GS + L C     P P +TW++D   +  +    ++  
Sbjct: 1926 TLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSR 1985

Query: 290  ---LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVA-----VEGE 341
               L+L  + PA+ G Y C+AEN   +  +   ++V+ A   P +  + VA     +EG+
Sbjct: 1986 GGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVA---PRIRSSGVAREHHVLEGQ 2042

Query: 342  TVSILCSTQSNPDPILTIFKEKQILSTVI------YESELQLELPAVSPEDDGEYWCVAE 395
             V + C     P P +   K+   L   +      Y     L L  +   D G Y CVA 
Sbjct: 2043 EVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAH 2102

Query: 396  NQYGQRATAFNLSVEFAPVL 415
            N  G+ A    ++V   P +
Sbjct: 2103 NPAGEDARLHTVNVLVPPTI 2122



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 64/291 (21%), Positives = 117/291 (40%), Gaps = 27/291 (9%)

Query: 141  PNIVVP--PEVVAGT---EVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGT 195
            PNIV P  P  V G    ++ + C V     E  P+++W   +G+           + G 
Sbjct: 2389 PNIVGPRGPRFVVGLAPGQLVLECSVE---AEPAPKITW-HRDGIVLQEDAHTQFPERGR 2444

Query: 196  WVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGS 255
            ++Q+  L    T ++  +    + +  +T++ F     +++   P I     +V      
Sbjct: 2445 FLQLQALS---TADSGDYSCTARNAAGSTSVAFR----VEIHTVPTIRSGPPAVNVSVNQ 2497

Query: 256  HVSLLCGADSNPPPLLTWMRDGTVL-----REAVAESLLLELEEVTPAEDGVYACLAENA 310
               L C AD  P PL++W +D   L     R  +     L ++ V   + G Y CLA N+
Sbjct: 2498 TALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNS 2557

Query: 311  YGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVI 370
             G D +   L V+  P        +         + C    +P P++  +K+ Q L   +
Sbjct: 2558 AGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRL 2617

Query: 371  YESELQ------LELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL 415
             +   +      L L A  P+D  ++ CV  N+ G+    + ++V   P +
Sbjct: 2618 QQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTI 2668



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 53/201 (26%), Positives = 84/201 (41%), Gaps = 15/201 (7%)

Query: 254  GSHVSLLCGADSNPPPLLTWMRDGTVLREAVAES---LLLELEEVTPAEDGVYACLAENA 310
            G  + L C A  +P P + W  +   + E V+E      L+   V+  + G Y C AEN 
Sbjct: 2952 GDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENR 3011

Query: 311  YGQDNRTVGLSVMYAPWKPTVNGT----MVAVEGETVSILCSTQSNPDPILTIFKEKQIL 366
             G   RT  +S ++    P + G     +V   G ++ + C  + +P P +   K+   L
Sbjct: 3012 VG---RTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPL 3068

Query: 367  STVIYESELQ---LELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAA 423
                   +LQ   L +     +D G Y C+AEN+ G       L ++ APV  +E     
Sbjct: 3069 RGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMT 3128

Query: 424  AR--DTVQCLCVVKSNPEPSV 442
             R  D V   C     P P++
Sbjct: 3129 VRSGDDVALRCQATGEPTPTI 3149



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 80/322 (24%), Positives = 123/322 (38%), Gaps = 43/322 (13%)

Query: 150 VAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVS----LLHFV 205
           + G  +E+ C    +     P + WL +   G PA       +E   VQV+     LH  
Sbjct: 511 IVGQPLELPCQASGSPV---PTIQWLQN---GRPA-------EELAGVQVASQGTTLHID 557

Query: 206 PTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEM-----------NSSVEAIEG 254
                +     CQA+    T   E   S+  ++ P ++E+           +SS  A   
Sbjct: 558 HVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACD 617

Query: 255 SHVSLLCGADSNPPPLLTWMRDGTVLREA----VAESLL--LELEEVTPAEDGVYACLAE 308
             V    GA   PP +  W   G++  E     VA SL   L++E+V   ++G+Y C A 
Sbjct: 618 PPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAAT 677

Query: 309 NAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILS- 367
           N  G+  R V L V+  P           +E  +V++ C     P P ++ FK  Q +S 
Sbjct: 678 NLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSS 737

Query: 368 ----TVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHC-- 421
               TV  +  + L +      D G Y CVA N  G     + L V   P + L      
Sbjct: 738 WMGVTVSVDGRV-LRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPG 796

Query: 422 -AAARDTVQCLCVVKSNPEPSV 442
                  V+  C     P P++
Sbjct: 797 PVLVNTPVRLTCNATGAPSPTL 818



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 81/332 (24%), Positives = 128/332 (38%), Gaps = 54/332 (16%)

Query: 148 EVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPT 207
           + VAG  V + C+   +     P LSW  HEGL          E +G     S+L     
Sbjct: 416 KAVAGRPVALECVARGHPS---PTLSW-HHEGLPVAESNESRLETDG-----SVLRLESP 466

Query: 208 REANGHRLGCQASFP--NTTLQFEGYASMDVKYPP--VIVEMNSSVEAIEGSHVSLLCGA 263
            EA+     C AS P     LQ+    S++V+ PP  ++ E    V  I G  + L C A
Sbjct: 467 GEASSGLYSCVASSPAGEAVLQY----SVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQA 522

Query: 264 DSNPPPLLTWMRDGTVLRE-----AVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTV 318
             +P P + W+++G    E       ++   L ++ V     G++AC A N  G     V
Sbjct: 523 SGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEV 582

Query: 319 GLSVMYAPWKPTVNGTMVA------VEGETVSILCSTQ------SNPDPIL--------T 358
            +SV +  W P V    +           +    C         ++P P L        +
Sbjct: 583 EVSV-HGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGS 641

Query: 359 IFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQ--RATAFNL----SVEFA 412
           ++ E   +  V Y     L++  V   D+G Y C A N  G+  R  A  +    ++E  
Sbjct: 642 LWGEPTGI-PVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPG 700

Query: 413 PVLLLESHCAAARDTVQCLCVVKSNPEPSVAF 444
           PV    +       +V   C+    P P V++
Sbjct: 701 PV----NKAVLENASVTLECLASGVPPPDVSW 728



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 68/255 (26%), Positives = 102/255 (40%), Gaps = 24/255 (9%)

Query: 170  PELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFE 229
            P + W  ++    P   G   +D G+ +Q + +    +RE +G  + C A   N   + +
Sbjct: 2967 PRIGWTVND---RPVTEGVSEQDGGSTLQRAAV----SREDSGTYV-CWAE--NRVGRTQ 3016

Query: 230  GYASMDVKYPPVIVEMNSS--VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAES 287
              + + VK  PV+     S  VE + GS + L C    +P P + W++DG  LR +    
Sbjct: 3017 AVSFVHVKEAPVLQGEAFSYLVEPVGGS-IQLDCVVRGDPVPDIHWIKDGLPLRGSHLRH 3075

Query: 288  LL----LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETV 343
             L    L +      + G Y CLAEN  G   + V L +  AP        M    G+ V
Sbjct: 3076 QLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDV 3135

Query: 344  SILCSTQSNPDPILTIFKEKQILST-----VIYESELQLELPAVSPEDDGEYWCVAENQY 398
            ++ C     P P +   +  Q L        + +  L LE   V   D G Y CVA N  
Sbjct: 3136 ALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLE--NVETGDAGTYDCVAHNLL 3193

Query: 399  GQRATAFNLSVEFAP 413
            G       L V   P
Sbjct: 3194 GSATARAFLVVRGEP 3208



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 54/231 (23%), Positives = 83/231 (35%), Gaps = 13/231 (5%)

Query: 239  PPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAE-------SLLLE 291
            PP I    S++     +   L C A  +P PL+ W +DG  L   + +       S  L 
Sbjct: 2572 PPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALL 2631

Query: 292  LEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQS 351
            L    P +   + C+  N  G+ +R   ++V   P                V + C +  
Sbjct: 2632 LTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTG 2691

Query: 352  NPDPILTIFKEKQIL----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNL 407
             P P ++  K    L    S         LE+    P   G Y C A N  G       L
Sbjct: 2692 IPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFL 2751

Query: 408  SVEFAPVL--LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNES 456
            +V+ +PV+  L     A A + V   C     P P++ ++    NV    S
Sbjct: 2752 TVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVS 2802



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 65/280 (23%), Positives = 100/280 (35%), Gaps = 60/280 (21%)

Query: 217 CQASFPNTTLQFEGYASMDVKYPPVIVE--MNSSVEAIEGSHVSLLCGADSNPPPLLTWM 274
           CQA+  N        A + V  PP I E    ++V  + G  ++L C A+  P P + W+
Sbjct: 74  CQAT--NEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWL 131

Query: 275 RDGTVL--------------------REAVAESLLLELEEVTPAEDGVYACLA-ENAYGQ 313
           +D  ++                       + E   L    + P   G     A  +A  +
Sbjct: 132 KDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTK 191

Query: 314 DNRTVGLS---------VMYAPWKPTVNGTMVAVE-----GETVSILCSTQSNPDPILTI 359
                GL+             P  P+V G   A E     G  V + C T   P P +  
Sbjct: 192 APWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEW 251

Query: 360 FKEKQIL-----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAP- 413
            K++Q +        + E    L +      D+G Y CVA +  GQ+A  F L V   P 
Sbjct: 252 TKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPT 311

Query: 414 ---------VLLLESHCAAARDTVQCLCVVKSNPEPSVAF 444
                    V ++E H       VQ LC  +  P P++ +
Sbjct: 312 IWGSNETGEVAVMEDH------LVQLLCEARGVPTPNITW 345



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 35/116 (30%), Positives = 50/116 (43%), Gaps = 12/116 (10%)

Query: 261 CGADSNPPPLLTWMRDGTVLRE-------AVAESLLLELEEVTPAEDGVYACLAENAYGQ 313
           CG    P P +TW R G            AV E   L L  V+PA+ G Y C A N  G 
Sbjct: 24  CGTHGTPKPQVTW-RKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGS 82

Query: 314 DNRTVGLSVMYAPWKPTVNGTMVAVE---GETVSILCSTQSNPDPILTIFKEKQIL 366
            +R   L V+Y P     +G    V    G+++++ C     P P +   K+ Q++
Sbjct: 83  TSRRAKL-VVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLV 137



 Score = 30.8 bits (68), Expect = 3.9
 Identities = 23/72 (31%), Positives = 28/72 (38%), Gaps = 5/72 (6%)

Query: 347 CSTQSNPDPILTIFKEKQILST-----VIYESELQLELPAVSPEDDGEYWCVAENQYGQR 401
           C T   P P +T  K            V    E  L L +VSP D G+Y C A N+ G  
Sbjct: 24  CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGST 83

Query: 402 ATAFNLSVEFAP 413
           +    L V   P
Sbjct: 84  SRRAKLVVYVPP 95


>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 5065

 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 93/353 (26%), Positives = 155/353 (43%), Gaps = 33/353 (9%)

Query: 131  EHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLR 190
            +H  L +  +P +   P VV     E   +  +     RP ++W   EGL     +    
Sbjct: 3938 KHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQ-KEGLNVATGVSTQV 3996

Query: 191  EDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVE 250
               G   Q+ + H  P  E  G+ L C A   N+     G   + V+ PPVI      + 
Sbjct: 3997 LPGG---QLRIAHASP--EDAGNYL-CIAK--NSAGSAMGKTRLVVQVPPVIENGLPDLS 4048

Query: 251  AIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-----VAESLLLELEEVTPAEDGVYAC 305
              EGSH  L C A  +P P +TW +DG  +  A     +  S  L ++ +   + G Y C
Sbjct: 4049 TTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTC 4108

Query: 306  LAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQI 365
             AENA G+  R V L+++  P   T+ G      G+ + + C+ + +P P +      + 
Sbjct: 4109 TAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRP 4168

Query: 366  LSTVIYESE--LQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAA 423
            ++  + E +    L+  AVS ED G Y C AEN+ G+      + V+ APVL  E+    
Sbjct: 4169 VTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYL 4228

Query: 424  AR---DTVQCLCVVKSNPEPSVAF--------------ELPSRNVTVNESERE 459
                  ++Q  CVV+ +P P + +              +L + ++T++ +ER+
Sbjct: 4229 VEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERD 4281



 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 93/329 (28%), Positives = 138/329 (41%), Gaps = 35/329 (10%)

Query: 143  IVVPPEVVAGTE-------VEVSCMVPDNCPELR---PELSWLGHEGLGEPAVLGRLRED 192
            ++ PP ++  TE       V  S  V   CP L    P +SWL +     P+   ++ ED
Sbjct: 2838 VLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLED 2897

Query: 193  EGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMN-SSVEA 251
             G  +QVS         A+     C A   N     E   ++ V+ PP I  ++   V A
Sbjct: 2898 -GQVLQVSTAEV-----ADAASYMCVAE--NQAGSAEKLFTLRVQVPPRIAGLDLEQVTA 2949

Query: 252  IEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-----LELEEVTPAEDGVYACL 306
            I  S VSL C   ++P P +TW +D   L       LL     L+L     ++ G+Y C 
Sbjct: 2950 ILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCE 3009

Query: 307  AENAYGQDNRTVGLSVMYAP-WKPTVNGTMVAV---EGETVSILCSTQSNPDPILTIFKE 362
            A NA G+D + V LSV+  P ++    G   AV    G+   + C T + P+P +T +K+
Sbjct: 3010 ALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKD 3069

Query: 363  KQIL----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL--- 415
             Q L     T       +LE+      D G Y C   N  G+    F L+V+  P     
Sbjct: 3070 GQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENP 3129

Query: 416  LLESHCAAARDTVQCLCVVKSNPEPSVAF 444
              E+    A   +   C V   P P+V +
Sbjct: 3130 KTETVSQVAGSPLVLTCDVSGVPAPTVTW 3158



 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 93/374 (24%), Positives = 151/374 (40%), Gaps = 29/374 (7%)

Query: 137 IVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTW 196
           +V  PN+ V P    G    +SC V    P     L+W+  +    PA  GR+ +     
Sbjct: 520 LVPAPNVTVSP----GETAVLSCRVLGEAPY---NLTWV-RDWRVLPASTGRVAQLADLS 571

Query: 197 VQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSH 256
           +++S +  +PT   +G R  C AS  N   +   +  + V+  P +    SS    +G  
Sbjct: 572 LEISGI--IPT---DGGRYQCVASNANGVTRASVW--LLVREAPQVSIHTSSQHFSQGVE 624

Query: 257 VSLLCGADSNPPPLLTWMRDGTVLREA----VAESLLLELEEVTPAEDGVYACLAENAYG 312
           V + C A   P P ++W R+   L+E     V     L ++ V P + G Y+C A N  G
Sbjct: 625 VKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVG 684

Query: 313 QDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFK-EKQILSTVIY 371
            D  TV L     P    VN  ++   GE   ++C     P P +  ++   +++     
Sbjct: 685 TDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEG 744

Query: 372 ESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL--LLESHCAAARDTVQ 429
            S  +L +PA    D G Y C A N+ G  +    L+V  AP L  L          +  
Sbjct: 745 SSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSAL 804

Query: 430 CLCVVKSNPEPSVAF---ELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQAQAPPRV 486
             C     P P+V +   +     + +            SG++     ++  + QAP   
Sbjct: 805 LACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFE--SVAPEDQAP--Y 860

Query: 487 ICTARNLYGAKSLE 500
           +C ARN++G    E
Sbjct: 861 VCEARNVFGKVQAE 874



 Score = 83.2 bits (204), Expect = 7e-16
 Identities = 70/270 (25%), Positives = 112/270 (41%), Gaps = 17/270 (6%)

Query: 236  VKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-----VAESLLL 290
            V  PP I +  +       + V L C +   P P ++W + G  L        V+ S  L
Sbjct: 3853 VHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGAL 3912

Query: 291  ELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQ 350
            E+ +  P   G Y C A N+ G  ++ V L+V  +P    +   + AV  E V + C   
Sbjct: 3913 EIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEAS 3972

Query: 351  SNPDPILTIFKEKQILSTVIYESEL---QLELPAVSPEDDGEYWCVAENQYGQRATAFNL 407
              P P +T  KE   ++T +    L   QL +   SPED G Y C+A+N  G       L
Sbjct: 3973 GIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRL 4032

Query: 408  SVEFAPVLL--LESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSER 465
             V+  PV+   L              C  + +PEP++ ++   +   V+ +E +F     
Sbjct: 4033 VVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQ--PVSGAEGKFTIQPS 4090

Query: 466  SGLVLTSILTLRGQAQAPPRVICTARNLYG 495
              L++ ++     + Q      CTA N  G
Sbjct: 4091 GELLVKNL-----EGQDAGTYTCTAENAVG 4115



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 93/419 (22%), Positives = 163/419 (38%), Gaps = 51/419 (12%)

Query: 142  NIVVPPEVVAGTEVEVSCMVPDNCPELR---------PELSWLGHEGLGEPAVLGRLRED 192
            +++VPPE++   +   +     + P            P + W   E   EP   G   ED
Sbjct: 2345 SVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGE---EPVSPG---ED 2398

Query: 193  EGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIV--EMNSSVE 250
                    +L    T+E +     C AS  N   +     S++V  PP I   ++   ++
Sbjct: 2399 TYLLAGGWMLKMTQTQEQDSGLYSCLAS--NEAGEARRNFSVEVLVPPSIENEDLEEVIK 2456

Query: 251  AIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVA-----ESLLLELEEVTPAEDGVYAC 305
             ++G    L+C    +P P LTW +DG  L    A     + +LL++ +   +  G Y+C
Sbjct: 2457 VLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSC 2516

Query: 306  LAENAYGQDNRTVGLSVMYAPW-----KPTVNGTMVAVEGETVSILCSTQSNPDPILTIF 360
            +A NA G+  +   LSV+ AP      + + +  +       +S++C   + P P +T  
Sbjct: 2517 IAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWM 2576

Query: 361  KE----KQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL 416
            K+    +   +  +      L++     ED G+Y CV  N+ G+    +++ V   P + 
Sbjct: 2577 KDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSIS 2636

Query: 417  LESHC---------AAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSG 467
             +                 T+   C   + P P++ +    + VT   S R  V  E   
Sbjct: 2637 KDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVT--PSSRLQVLGEGRL 2694

Query: 468  LVLTSILTLRGQAQAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAIL 526
            L +        Q     R +C A N+ G    +         M+ K+G   A  AF IL
Sbjct: 2695 LQIQPT-----QVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSA--AFEIL 2746



 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 70/286 (24%), Positives = 117/286 (40%), Gaps = 30/286 (10%)

Query: 234  MDVKYPPVIV---EMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL- 289
            ++V  PP I    E  + V  ++    +L C A   PPP +TW RDG  +   +   L  
Sbjct: 2250 LEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQN 2309

Query: 290  ----LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAP-----WKPTVNGTMVAVEG 340
                L +E    A  G Y+C+AEN  G+  R   LSV+  P       P  N  + A   
Sbjct: 2310 QGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTN--ITAALH 2367

Query: 341  ETVSILCSTQSNPDPILTIFKEKQILS----TVIYESELQLELPAVSPEDDGEYWCVAEN 396
              +++LC     P P +  F+ ++ +S    T +      L++     +D G Y C+A N
Sbjct: 2368 SPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASN 2427

Query: 397  QYGQRATAFNLSVEFAPVL----LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVT 452
            + G+    F++ V   P +    L E        T   +C V  +P+P + +    R + 
Sbjct: 2428 EAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLA 2487

Query: 453  VNESEREFVYSERSGLVLTSILTLRGQAQAPPRVICTARNLYGAKS 498
              ++     +    G++L     L+    +     C A N  G K+
Sbjct: 2488 RGDAH----HISPDGVLLQ---VLQANLSSAGHYSCIAANAVGEKT 2526



 Score = 80.1 bits (196), Expect = 6e-15
 Identities = 87/368 (23%), Positives = 153/368 (41%), Gaps = 42/368 (11%)

Query: 149  VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSL----LHF 204
            V+ G EV + C      P   P+++WL     G P     L +D G  ++  L    L  
Sbjct: 3229 VLEGQEVRLDCEADGQPP---PDVAWLKD---GSP-----LGQDMGPHLRFYLDGGSLVL 3277

Query: 205  VPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVI---VEMNSSVEAIEGSHVSLLC 261
               R ++     C A   N   +     +++V  PP I    + + ++ +  G  V+++C
Sbjct: 3278 KGLRASDAGAYTCVAH--NPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVC 3335

Query: 262  GADSNPPPLLTWMRDGTVLREAVAESL-----LLELEEVTPAEDGVYACLAENAYGQDNR 316
                +PP  ++W++DG  L  +    L      L + +V  A+ G++ C+A +  G  +R
Sbjct: 3336 PVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADR 3395

Query: 317  TVGLSVMYAPWKPTVN--GTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESE 374
               L V   P    V     +V V G  V + C  +  P P+++  K+ + L +   E  
Sbjct: 3396 NFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQG 3455

Query: 375  LQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAAARDT----VQC 430
              L+L AV   D G Y CVA ++ G+    F L+V   P +           T    ++ 
Sbjct: 3456 PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMEL 3515

Query: 431  LCVVKSNPEPSVAFELPSRNVT--VNESEREFVYSERSGLVLTSIL---------TLRGQ 479
            LC  +  P+P++ +    + +T   N S    V   R   + T +          + R +
Sbjct: 3516 LCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVR 3575

Query: 480  AQAPPRVI 487
             QAPP ++
Sbjct: 3576 VQAPPNIV 3583



 Score = 79.7 bits (195), Expect = 7e-15
 Identities = 60/225 (26%), Positives = 96/225 (42%), Gaps = 35/225 (15%)

Query: 255  SHVSLLCGADSNPPPLLTWMRDGTVLR-----EAVAESLLLELEEVTPAEDGVYACLAEN 309
            S ++L C + + PPP + W +DG  +      + + E  LL+++    ++ G Y C+A N
Sbjct: 2655 STLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATN 2714

Query: 310  AYGQDNRTVGLSVMYAPWKPTVNGTMVA--------------------VEGETVSILCST 349
              G+D++   + +   P    V     A                    VE     + C T
Sbjct: 2715 VAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDT 2774

Query: 350  QSNPDPILTIFKEKQILSTVIYESELQ----LELPAVSPEDDGEYWCVAENQYGQRATAF 405
             + P P LT ++E Q LS     S LQ    L++P V  E+ G Y C A N+ G+    +
Sbjct: 2775 NAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHY 2834

Query: 406  NLSVEFAPVL------LLESHCAAARDTVQCLCVVKSNPEPSVAF 444
             L V   PV+      L+E     A  TV   C    NP P++++
Sbjct: 2835 ELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISW 2879



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 91/351 (25%), Positives = 138/351 (39%), Gaps = 57/351 (16%)

Query: 130  SEHSVLDIVNTPNIVVPP---EVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVL 186
            S   VL +   P +   P   +V+ G  ++++C+   N PE  P+LSW       +  V+
Sbjct: 1109 SHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGN-PE--PQLSW------SKDGVV 1159

Query: 187  GRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPV--IVE 244
             + R  +G+      +HF   R ++  R  C+AS       +E    + V  PP     E
Sbjct: 1160 LQGRGPQGS------VHFAAIRTSDAGRYRCEASNSAGVDAWE--VELRVLEPPHWGADE 1211

Query: 245  MNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLRE-------AVAESLLLELEEVTP 297
             +  +E + G + SL C A   P P +TW R G            AV E   L L  V+P
Sbjct: 1212 TSGLLERVAGENASLPCPARGTPKPQVTW-RKGPSSEPLHGQPGVAVLEEGSLFLASVSP 1270

Query: 298  AEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEG---ETVSILCSTQSNPD 354
            A+ G Y C A N  G  +R   L V+Y P     +G    V G   +++++ C     P 
Sbjct: 1271 ADSGDYECQATNEVGSTSRRAKL-VVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPV 1329

Query: 355  PILTIFKEKQILSTVI-------------------YESELQLELPAVSPEDDGEYWCVAE 395
            P +   K+ Q++   +                    +    L  P +   D G Y C AE
Sbjct: 1330 PEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAE 1389

Query: 396  NQYGQRATAFNLSVEFAPVLL----LESHCAAARDTVQCLCVVKSNPEPSV 442
            NQ G     F+L V   P +L     +     A   V+  C     P P V
Sbjct: 1390 NQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQV 1440



 Score = 76.6 bits (187), Expect = 6e-14
 Identities = 94/383 (24%), Positives = 142/383 (37%), Gaps = 51/383 (13%)

Query: 141  PNIVVPPE----VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTW 196
            P I +PP     V+  T V ++C      P   P L WL       PA    L+   G  
Sbjct: 1977 PRITLPPSLPGPVLVNTPVRLTCNAT-GAPS--PTLMWLKDGNPVSPAGTPGLQVFPGGR 2033

Query: 197  VQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSH 256
            V    L     R ++  R  C A   +   +      + V  PP I+    +V  +    
Sbjct: 2034 V----LTLASARASDSGRYSCVAV--SAVGEDRQDVVLQVHMPPSILGEELNVSVVANES 2087

Query: 257  VSLLCGADSNPPPLLTWMRDGTVLR-----EAVAESLLLELEEVTPAEDGVYACLAENAY 311
            V+L C + + PPP+L+W +DG  L         A+  LL+++     + G Y C A N  
Sbjct: 2088 VALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQA 2147

Query: 312  GQDNRTVGLSVMYAPWKP-TVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQIL---- 366
            G   +   L+V  AP  P   + T+   EG   S+ C  +  P P ++  K+ Q L    
Sbjct: 2148 GHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEG 2207

Query: 367  ---------STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL- 416
                       ++Y  + QL         +G Y C   N  G  +    L V   P +  
Sbjct: 2208 AGLQHVSAVGRLLYLGQAQL-------AQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAG 2260

Query: 417  ---LESHCAAARDTVQCL-CVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTS 472
                 +  +  +D V  L C     P P+V +E   + V         +  +  G    S
Sbjct: 2261 PREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELG----LQLQNQG---QS 2313

Query: 473  ILTLRGQAQAPPRVICTARNLYG 495
            +   R QA    R  C A NL G
Sbjct: 2314 LHVERAQAAHTGRYSCVAENLAG 2336



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 55/176 (31%), Positives = 77/176 (43%), Gaps = 8/176 (4%)

Query: 232 ASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVL-----REAVAE 286
           A + V  PP  +    +V    G    L C      P  LTW+RD  VL     R A   
Sbjct: 509 AQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLA 568

Query: 287 SLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSIL 346
            L LE+  + P + G Y C+A NA G    +V L V  AP       +    +G  V + 
Sbjct: 569 DLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVS 628

Query: 347 CSTQSNPDPILTIFKEKQIL---STVIYESELQLELPAVSPEDDGEYWCVAENQYG 399
           CS    P P ++  +E Q L   S +  +++  L +  V+PED G Y C A N+ G
Sbjct: 629 CSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVG 684



 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 67/239 (28%), Positives = 100/239 (41%), Gaps = 13/239 (5%)

Query: 186  LGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYAS----MDVKYPPV 241
            + RL   +  W +  LL     R A   ++G    +  T     G AS    + V+ PP 
Sbjct: 1063 VNRLALSKYVWEEYGLLPSGSLRLAQV-QVGDSGHYECTASNPAGSASHRYVLGVQVPPQ 1121

Query: 242  IVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDG 301
            +      ++ + G  + L C A+ NP P L+W +DG VL+    +   +    +  ++ G
Sbjct: 1122 VQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQGRGPQG-SVHFAAIRTSDAG 1180

Query: 302  VYACLAENAYGQDNRTVGLSVMYAP-W-KPTVNGTMVAVEGETVSILCSTQSNPDPILTI 359
             Y C A N+ G D   V L V+  P W     +G +  V GE  S+ C  +  P P +T 
Sbjct: 1181 RYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTW 1240

Query: 360  FKEKQI-----LSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAP 413
             K            V    E  L L +VSP D G+Y C A N+ G  +    L V   P
Sbjct: 1241 RKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPP 1299



 Score = 72.8 bits (177), Expect = 9e-13
 Identities = 63/224 (28%), Positives = 92/224 (41%), Gaps = 20/224 (8%)

Query: 250  EAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-----LELEEVTPAEDGVYA 304
            E +E +   L C  ++ PPP LTW R+   L      S+L     L++  V     G Y+
Sbjct: 2761 EIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYS 2820

Query: 305  CLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVE------GETVSILCSTQSNPDPILT 358
            C A N  G+D     L V+  P    +  T   VE        TVS+ C    NP P ++
Sbjct: 2821 CKASNEVGEDWLHYELLVLTPP--VILGDTEELVEEVTVNASSTVSLQCPALGNPVPTIS 2878

Query: 359  IFKEKQILS----TVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPV 414
              +     S      + E    L++      D   Y CVAENQ G     F L V+  P 
Sbjct: 2879 WLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPR 2938

Query: 415  LL---LESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNE 455
            +    LE   A    +V   C V ++P P V +   S+ +++ E
Sbjct: 2939 IAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGE 2982



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 63/229 (27%), Positives = 97/229 (42%), Gaps = 26/229 (11%)

Query: 236  VKYPPVIVEMNSS--VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-----VAESL 288
            V  PP I   N +  V  +E   V LLC A   P P +TW +DG +L  +          
Sbjct: 1497 VHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGR 1556

Query: 289  LLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNG------TMVAVEGET 342
             L+L     ++ GVY C A NA G   +   L V Y P  PT+ G       + AV G  
Sbjct: 1557 QLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV-YVP--PTIEGAGGRPYVVKAVAGRP 1613

Query: 343  VSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGE-----YWCVAENQ 397
            V++ C  + +P P L+ +  + +      ES L+ +   +  E  GE     Y CVA + 
Sbjct: 1614 VALECVARGHPSPTLS-WHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSP 1672

Query: 398  YGQRATAFNLSVEFAPVLLLESHCAAARDTV----QCLCVVKSNPEPSV 442
             G+    +++ V+  P LL+          V    +  C    +P P++
Sbjct: 1673 AGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTI 1721



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 95/381 (24%), Positives = 143/381 (37%), Gaps = 53/381 (13%)

Query: 134  VLDIVNTPNIVVPPEVVAGTEVEVSCM---VPDNCPELRPELSWLGHEGLGEPAVLGRLR 190
            VL+ V   N VV   VV G+ VE+ C    VP       P +SW+     GEP +   L 
Sbjct: 3406 VLEPVEFQNDVV---VVRGSLVELPCEARGVP------LPLVSWMKD---GEPLLSQSLE 3453

Query: 191  EDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYA----SMDVKYPPVIVEMN 246
            +              P+ +      G   ++    +   G A     + V  PP I +  
Sbjct: 3454 QG-------------PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSG 3500

Query: 247  SSVEA--IEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDGVYA 304
               E     G+ + LLC A   P P +TW +DG  L      S    +  V  A  G+Y 
Sbjct: 3501 QPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDA--GLYT 3558

Query: 305  CLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAV---EGETVSILCSTQSNPDPILTIFK 361
            CLAE+  G   ++  + V   P      G    V    G+ V + CS ++ P P +T  +
Sbjct: 3559 CLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLV-LECSVEAEPAPKITWHR 3617

Query: 362  EKQILS----TVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLL 417
            +  +L     T   E    L+L A+S  D G+Y C A N  G  + AF + +   P +  
Sbjct: 3618 DGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRS 3677

Query: 418  ESHC--AAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILT 475
                   +   T    C     P P V++      V ++     F       L +  +L 
Sbjct: 3678 GPPAVNVSVNQTALLPCQADGVPAPLVSWR--KDRVPLDPRSPRFEILPEGSLRIQPVL- 3734

Query: 476  LRGQAQAPPRVICTARNLYGA 496
                AQ     +C A N  G+
Sbjct: 3735 ----AQDAGHYLCLASNSAGS 3751



 Score = 69.7 bits (169), Expect = 8e-12
 Identities = 50/200 (25%), Positives = 86/200 (43%), Gaps = 20/200 (10%)

Query: 233  SMDVKYPPVIVEMNS-SVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-- 289
            ++ V+ PP      + +V  + GS + L C     P P +TW++D   +  +    ++  
Sbjct: 3117 TLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSR 3176

Query: 290  ---LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVA-----VEGE 341
               L+L  + PA+ G Y C+AEN   +  +   ++V+ A   P +  + VA     +EG+
Sbjct: 3177 GGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVA---PRIRSSGVAREHHVLEGQ 3233

Query: 342  TVSILCSTQSNPDPILTIFKEKQILSTVI------YESELQLELPAVSPEDDGEYWCVAE 395
             V + C     P P +   K+   L   +      Y     L L  +   D G Y CVA 
Sbjct: 3234 EVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAH 3293

Query: 396  NQYGQRATAFNLSVEFAPVL 415
            N  G+ A    ++V   P +
Sbjct: 3294 NPAGEDARLHTVNVLVPPTI 3313



 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 71/272 (26%), Positives = 100/272 (36%), Gaps = 16/272 (5%)

Query: 149  VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTR 208
            V  G    ++C      P   P ++W   +G      LG  R          +L F    
Sbjct: 797  VELGRSALLACRATGRPP---PTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVA 853

Query: 209  EANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPP 268
              +     C+A      +Q E    +    PP I     +V  +EG  VSL C   +  P
Sbjct: 854  PEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRP 913

Query: 269  -PLLTWMRDGTVL----REAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVM 323
             P   W++DG  L    R ++     L L+       G Y+C+A N  G  +R V L V 
Sbjct: 914  LPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQ 973

Query: 324  YAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILST------VIYESELQL 377
              P         +  EG   S+ C     P P +T  KE   L++      V  E  L +
Sbjct: 974  VPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLI 1033

Query: 378  ELPAVSPEDDGEYWCVAENQYGQRATAFNLSV 409
              P  S +D G Y C A N  G  +    LSV
Sbjct: 1034 AQP--SAQDAGAYVCTATNTVGFSSQEMRLSV 1063



 Score = 66.6 bits (161), Expect = 6e-11
 Identities = 68/270 (25%), Positives = 104/270 (38%), Gaps = 53/270 (19%)

Query: 217  CQASFPNTTLQFEGYASMDVKYPPVIVE--MNSSVEAIEGSHVSLLCGADSNPPPLLTWM 274
            CQA+  N        A + V  PP I E    ++V  + G  ++L C A+  P P + W+
Sbjct: 1278 CQAT--NEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWL 1335

Query: 275  RDGTVL--------------------REAVAESLLLELEEVTPAEDGVYACLAENAYGQD 314
            +D  ++                       + E   L    +   + G+Y+C AEN  G  
Sbjct: 1336 KDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTA 1395

Query: 315  NRTVGLSVMYAPWKPTVNGTMVAVE-----GETVSILCSTQSNPDPILTIFKEKQIL--- 366
             R   L V+  P   +V G   A E     G  V + C T   P P +   K++Q +   
Sbjct: 1396 QRDFHLLVLTPP---SVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPG 1452

Query: 367  --STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAP----------V 414
                 + E    L +      D+G Y CVA +  GQ+A  F L V   P          V
Sbjct: 1453 GPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEV 1512

Query: 415  LLLESHCAAARDTVQCLCVVKSNPEPSVAF 444
             ++E H       VQ LC  +  P P++ +
Sbjct: 1513 AVMEDH------LVQLLCEARGVPTPNITW 1536



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 103/422 (24%), Positives = 154/422 (36%), Gaps = 44/422 (10%)

Query: 101  TLLLSNVSPELGGKYYFRG--DLGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVS 158
            TL++  V+PE  G Y  +   ++G   +     ++    V+  N VV   V  G E  + 
Sbjct: 661  TLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVL--VAVGEEAVLV 718

Query: 159  CMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQ 218
            C      P   P + W  + G G   +L       G       L     +E +     C+
Sbjct: 719  CEASGVPP---PRVIW--YRG-GLEMILAPEGSSSGK------LRIPAAQERDAGTYTCR 766

Query: 219  ASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMR-DG 277
            A   N          + V + P + E+   V    G    L C A   PPP +TW R DG
Sbjct: 767  AV--NELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDG 824

Query: 278  TVL----------REAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVM-YAP 326
              L          R    +S +L  E V P +   Y C A N +G+      L V  +AP
Sbjct: 825  QPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAP 884

Query: 327  WKPTVNGTMVAV-EGETVSILCSTQSN-PDPILTIFKEKQIL---STVIYESELQLELPA 381
             +   +   V V EG+ VS+ C   +  P P     K+ + L   S     ++  L L  
Sbjct: 885  PQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDR 944

Query: 382  VSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL--LLESHCAAARDTVQCLCVVKSNPE 439
               E  G Y CVA N  G +     L V+  P +      H           CV    P 
Sbjct: 945  ALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPA 1004

Query: 440  PSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQAQAPPRVICTARNLYGAKSL 499
            P++ +   +  +T   S        + G    ++L  +  AQ     +CTA N  G  S 
Sbjct: 1005 PTITWTKETNALT---SRGPHYNVSKEG----TLLIAQPSAQDAGAYVCTATNTVGFSSQ 1057

Query: 500  EL 501
            E+
Sbjct: 1058 EM 1059



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 64/291 (21%), Positives = 117/291 (40%), Gaps = 27/291 (9%)

Query: 141  PNIVVP--PEVVAGT---EVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGT 195
            PNIV P  P  V G    ++ + C V     E  P+++W   +G+           + G 
Sbjct: 3580 PNIVGPRGPRFVVGLAPGQLVLECSVE---AEPAPKITW-HRDGIVLQEDAHTQFPERGR 3635

Query: 196  WVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGS 255
            ++Q+  L    T ++  +    + +  +T++ F     +++   P I     +V      
Sbjct: 3636 FLQLQALS---TADSGDYSCTARNAAGSTSVAFR----VEIHTVPTIRSGPPAVNVSVNQ 3688

Query: 256  HVSLLCGADSNPPPLLTWMRDGTVL-----REAVAESLLLELEEVTPAEDGVYACLAENA 310
               L C AD  P PL++W +D   L     R  +     L ++ V   + G Y CLA N+
Sbjct: 3689 TALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNS 3748

Query: 311  YGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVI 370
             G D +   L V+  P        +         + C    +P P++  +K+ Q L   +
Sbjct: 3749 AGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRL 3808

Query: 371  YESELQ------LELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL 415
             +   +      L L A  P+D  ++ CV  N+ G+    + ++V   P +
Sbjct: 3809 QQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTI 3859



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 53/201 (26%), Positives = 84/201 (41%), Gaps = 15/201 (7%)

Query: 254  GSHVSLLCGADSNPPPLLTWMRDGTVLREAVAES---LLLELEEVTPAEDGVYACLAENA 310
            G  + L C A  +P P + W  +   + E V+E      L+   V+  + G Y C AEN 
Sbjct: 4143 GDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENR 4202

Query: 311  YGQDNRTVGLSVMYAPWKPTVNGT----MVAVEGETVSILCSTQSNPDPILTIFKEKQIL 366
             G   RT  +S ++    P + G     +V   G ++ + C  + +P P +   K+   L
Sbjct: 4203 VG---RTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPL 4259

Query: 367  STVIYESELQ---LELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAA 423
                   +LQ   L +     +D G Y C+AEN+ G       L ++ APV  +E     
Sbjct: 4260 RGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMT 4319

Query: 424  AR--DTVQCLCVVKSNPEPSV 442
             R  D V   C     P P++
Sbjct: 4320 VRSGDDVALRCQATGEPTPTI 4340



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 80/322 (24%), Positives = 123/322 (38%), Gaps = 43/322 (13%)

Query: 150  VAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVS----LLHFV 205
            + G  +E+ C    +     P + WL +   G PA       +E   VQV+     LH  
Sbjct: 1702 IVGQPLELPCQASGSPV---PTIQWLQN---GRPA-------EELAGVQVASQGTTLHID 1748

Query: 206  PTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEM-----------NSSVEAIEG 254
                 +     CQA+    T   E   S+  ++ P ++E+           +SS  A   
Sbjct: 1749 HVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACD 1808

Query: 255  SHVSLLCGADSNPPPLLTWMRDGTVLREA----VAESLL--LELEEVTPAEDGVYACLAE 308
              V    GA   PP +  W   G++  E     VA SL   L++E+V   ++G+Y C A 
Sbjct: 1809 PPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAAT 1868

Query: 309  NAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILS- 367
            N  G+  R V L V+  P           +E  +V++ C     P P ++ FK  Q +S 
Sbjct: 1869 NLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSS 1928

Query: 368  ----TVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHC-- 421
                TV  +  + L +      D G Y CVA N  G     + L V   P + L      
Sbjct: 1929 WMGVTVSVDGRV-LRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPG 1987

Query: 422  -AAARDTVQCLCVVKSNPEPSV 442
                   V+  C     P P++
Sbjct: 1988 PVLVNTPVRLTCNATGAPSPTL 2009



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 81/332 (24%), Positives = 128/332 (38%), Gaps = 54/332 (16%)

Query: 148  EVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPT 207
            + VAG  V + C+   +     P LSW  HEGL          E +G     S+L     
Sbjct: 1607 KAVAGRPVALECVARGHPS---PTLSW-HHEGLPVAESNESRLETDG-----SVLRLESP 1657

Query: 208  REANGHRLGCQASFP--NTTLQFEGYASMDVKYPP--VIVEMNSSVEAIEGSHVSLLCGA 263
             EA+     C AS P     LQ+    S++V+ PP  ++ E    V  I G  + L C A
Sbjct: 1658 GEASSGLYSCVASSPAGEAVLQY----SVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQA 1713

Query: 264  DSNPPPLLTWMRDGTVLRE-----AVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTV 318
              +P P + W+++G    E       ++   L ++ V     G++AC A N  G     V
Sbjct: 1714 SGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEV 1773

Query: 319  GLSVMYAPWKPTVNGTMVA------VEGETVSILCSTQ------SNPDPIL--------T 358
             +SV +  W P V    +           +    C         ++P P L        +
Sbjct: 1774 EVSV-HGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGS 1832

Query: 359  IFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQ--RATAFNL----SVEFA 412
            ++ E   +  V Y     L++  V   D+G Y C A N  G+  R  A  +    ++E  
Sbjct: 1833 LWGEPTGI-PVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPG 1891

Query: 413  PVLLLESHCAAARDTVQCLCVVKSNPEPSVAF 444
            PV    +       +V   C+    P P V++
Sbjct: 1892 PV----NKAVLENASVTLECLASGVPPPDVSW 1919



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 68/255 (26%), Positives = 102/255 (40%), Gaps = 24/255 (9%)

Query: 170  PELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFE 229
            P + W  ++    P   G   +D G+ +Q + +    +RE +G  + C A   N   + +
Sbjct: 4158 PRIGWTVND---RPVTEGVSEQDGGSTLQRAAV----SREDSGTYV-CWAE--NRVGRTQ 4207

Query: 230  GYASMDVKYPPVIVEMNSS--VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAES 287
              + + VK  PV+     S  VE + GS + L C    +P P + W++DG  LR +    
Sbjct: 4208 AVSFVHVKEAPVLQGEAFSYLVEPVGGS-IQLDCVVRGDPVPDIHWIKDGLPLRGSHLRH 4266

Query: 288  LL----LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETV 343
             L    L +      + G Y CLAEN  G   + V L +  AP        M    G+ V
Sbjct: 4267 QLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDV 4326

Query: 344  SILCSTQSNPDPILTIFKEKQILST-----VIYESELQLELPAVSPEDDGEYWCVAENQY 398
            ++ C     P P +   +  Q L        + +  L LE   V   D G Y CVA N  
Sbjct: 4327 ALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLE--NVETGDAGTYDCVAHNLL 4384

Query: 399  GQRATAFNLSVEFAP 413
            G       L V   P
Sbjct: 4385 GSATARAFLVVRGEP 4399



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 54/231 (23%), Positives = 83/231 (35%), Gaps = 13/231 (5%)

Query: 239  PPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAE-------SLLLE 291
            PP I    S++     +   L C A  +P PL+ W +DG  L   + +       S  L 
Sbjct: 3763 PPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALL 3822

Query: 292  LEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQS 351
            L    P +   + C+  N  G+ +R   ++V   P                V + C +  
Sbjct: 3823 LTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTG 3882

Query: 352  NPDPILTIFKEKQIL----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNL 407
             P P ++  K    L    S         LE+    P   G Y C A N  G       L
Sbjct: 3883 IPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFL 3942

Query: 408  SVEFAPVL--LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNES 456
            +V+ +PV+  L     A A + V   C     P P++ ++    NV    S
Sbjct: 3943 TVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVS 3993



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 40/165 (24%), Positives = 65/165 (39%), Gaps = 6/165 (3%)

Query: 291 ELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQ 350
           E+   + AE+G Y C A +  G       + V   P +      +    GET  + C   
Sbjct: 482 EILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL 541

Query: 351 SNPDPILTIFKEKQIL----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFN 406
                 LT  ++ ++L      V   ++L LE+  + P D G Y CVA N  G    +  
Sbjct: 542 GEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVW 601

Query: 407 LSVEFAPVLLL--ESHCAAARDTVQCLCVVKSNPEPSVAFELPSR 449
           L V  AP + +   S   +    V+  C     P P +++   S+
Sbjct: 602 LLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQ 646



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 41/162 (25%), Positives = 60/162 (37%), Gaps = 12/162 (7%)

Query: 290  LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCST 349
            L L +V   + G Y C A N  G  +    L V   P        +  + GE + + C  
Sbjct: 1084 LRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVA 1143

Query: 350  QSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSV 409
            + NP+P L+  K+  +L       +  +   A+   D G Y C A N  G  A    L V
Sbjct: 1144 EGNPEPQLSWSKDGVVLQG--RGPQGSVHFAAIRTSDAGRYRCEASNSAGVDAWEVELRV 1201

Query: 410  EFAPVL-------LLESHCAAARDTVQCLCVVKSNPEPSVAF 444
               P         LLE     A +     C  +  P+P V +
Sbjct: 1202 LEPPHWGADETSGLLE---RVAGENASLPCPARGTPKPQVTW 1240


>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3783

 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 93/353 (26%), Positives = 154/353 (43%), Gaps = 33/353 (9%)

Query: 131  EHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLR 190
            +H  L +  +P +   P VV     E   +  +     RP ++W   EGL     +    
Sbjct: 2656 KHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQ-KEGLNVATGVSTQV 2714

Query: 191  EDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVE 250
               G   Q+ + H  P  E  G+ L C A   N+     G   + V+ PPVI      + 
Sbjct: 2715 LPGG---QLRIAHASP--EDAGNYL-CIAK--NSAGSAMGKTRLVVQVPPVIENGLPDLS 2766

Query: 251  AIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-----VAESLLLELEEVTPAEDGVYAC 305
              EGSH  L C A  +P P +TW +DG  +  A     +  S  L ++ +   + G Y C
Sbjct: 2767 TTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTC 2826

Query: 306  LAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQI 365
             AENA G+  R V L+++  P   T+ G      G+ + + C+ + +P P +      + 
Sbjct: 2827 TAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRP 2886

Query: 366  LSTVIYESE--LQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAA 423
            ++  + E +    L+  AVS ED G Y C AEN+ G+      + V+ APVL  E+    
Sbjct: 2887 VTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYL 2946

Query: 424  AR---DTVQCLCVVKSNPEPSVAF--------------ELPSRNVTVNESERE 459
                  ++Q  CVV+ +P P + +              +L + ++T+  +ER+
Sbjct: 2947 VEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERD 2999



 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 93/329 (28%), Positives = 138/329 (41%), Gaps = 35/329 (10%)

Query: 143  IVVPPEVVAGTE-------VEVSCMVPDNCPELR---PELSWLGHEGLGEPAVLGRLRED 192
            ++ PP ++  TE       V  S  V   CP L    P +SWL +     P+   ++ ED
Sbjct: 1556 VLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLED 1615

Query: 193  EGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMN-SSVEA 251
             G  +QVS         A+     C A   N     E   ++ V+ PP I  ++   V A
Sbjct: 1616 -GQVLQVSTAEV-----ADAASYMCVAE--NQAGSAEKLFTLRVQVPPRIAGLDLEQVTA 1667

Query: 252  IEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-----LELEEVTPAEDGVYACL 306
            I  S VSL C   ++P P +TW +D   L       LL     L+L     ++ G+Y C 
Sbjct: 1668 ILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCE 1727

Query: 307  AENAYGQDNRTVGLSVMYAP-WKPTVNGTMVAV---EGETVSILCSTQSNPDPILTIFKE 362
            A NA G+D + V LSV+  P ++    G   AV    G+   + C T + P+P +T +K+
Sbjct: 1728 ALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKD 1787

Query: 363  KQIL----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL--- 415
             Q L     T       +LE+      D G Y C   N  G+    F L+V+  P     
Sbjct: 1788 GQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENP 1847

Query: 416  LLESHCAAARDTVQCLCVVKSNPEPSVAF 444
              E+    A   +   C V   P P+V +
Sbjct: 1848 KTETVSQVAGSPLVLTCDVSGVPAPTVTW 1876



 Score = 83.2 bits (204), Expect = 7e-16
 Identities = 94/419 (22%), Positives = 164/419 (39%), Gaps = 51/419 (12%)

Query: 142  NIVVPPEVVAGTEVEVSCMVPDNCPELR---------PELSWLGHEGLGEPAVLGRLRED 192
            +++VPPE++   +   +     + P            P + W   E   EP   G   ED
Sbjct: 1063 SVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGE---EPVSPG---ED 1116

Query: 193  EGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIV--EMNSSVE 250
                    +L    T+E +     C AS  N   +     S++V  PP I   ++   ++
Sbjct: 1117 TYLLAGGWMLKMTQTQEQDSGLYSCLAS--NEAGEARRNFSVEVLVPPSIENEDLEEVIK 1174

Query: 251  AIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVA-----ESLLLELEEVTPAEDGVYAC 305
             ++G    L+C    +P P LTW +DG  L    A     + +LL++ +   +  G Y+C
Sbjct: 1175 VLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSC 1234

Query: 306  LAENAYGQDNRTVGLSVMYAPW-----KPTVNGTMVAVEGETVSILCSTQSNPDPILTIF 360
            +A NA G+  +   LSV+ AP      + + +  +       +S++C   + P P +T  
Sbjct: 1235 IAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWM 1294

Query: 361  KE----KQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL 416
            K+    +   +  +      L++     ED G+Y CV  N+ G+    +++ V   P + 
Sbjct: 1295 KDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSIS 1354

Query: 417  LESHCA---------AARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSG 467
             +   A             T+   C   + P P++ +    + VT   S R  V  E   
Sbjct: 1355 KDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVT--PSSRLQVLGEGRL 1412

Query: 468  LVLTSILTLRGQAQAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAIL 526
            L +        Q     R +C A N+ G    +         M+ K+G   A  AF IL
Sbjct: 1413 LQIQPT-----QVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSA--AFEIL 1464



 Score = 83.2 bits (204), Expect = 7e-16
 Identities = 70/270 (25%), Positives = 112/270 (41%), Gaps = 17/270 (6%)

Query: 236  VKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-----VAESLLL 290
            V  PP I +  +       + V L C +   P P ++W + G  L        V+ S  L
Sbjct: 2571 VHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGAL 2630

Query: 291  ELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQ 350
            E+ +  P   G Y C A N+ G  ++ V L+V  +P    +   + AV  E V + C   
Sbjct: 2631 EIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEAS 2690

Query: 351  SNPDPILTIFKEKQILSTVIYESEL---QLELPAVSPEDDGEYWCVAENQYGQRATAFNL 407
              P P +T  KE   ++T +    L   QL +   SPED G Y C+A+N  G       L
Sbjct: 2691 GIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRL 2750

Query: 408  SVEFAPVLL--LESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSER 465
             V+  PV+   L              C  + +PEP++ ++   +   V+ +E +F     
Sbjct: 2751 VVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQ--PVSGAEGKFTIQPS 2808

Query: 466  SGLVLTSILTLRGQAQAPPRVICTARNLYG 495
              L++ ++     + Q      CTA N  G
Sbjct: 2809 GELLVKNL-----EGQDAGTYTCTAENAVG 2833



 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 70/286 (24%), Positives = 117/286 (40%), Gaps = 30/286 (10%)

Query: 234  MDVKYPPVIV---EMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL- 289
            ++V  PP I    E  + V  ++    +L C A   PPP +TW RDG  +   +   L  
Sbjct: 968  LEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQN 1027

Query: 290  ----LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAP-----WKPTVNGTMVAVEG 340
                L +E    A  G Y+C+AEN  G+  R   LSV+  P       P  N  + A   
Sbjct: 1028 QGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTN--ITAALH 1085

Query: 341  ETVSILCSTQSNPDPILTIFKEKQILS----TVIYESELQLELPAVSPEDDGEYWCVAEN 396
              +++LC     P P +  F+ ++ +S    T +      L++     +D G Y C+A N
Sbjct: 1086 SPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASN 1145

Query: 397  QYGQRATAFNLSVEFAPVL----LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVT 452
            + G+    F++ V   P +    L E        T   +C V  +P+P + +    R + 
Sbjct: 1146 EAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLA 1205

Query: 453  VNESEREFVYSERSGLVLTSILTLRGQAQAPPRVICTARNLYGAKS 498
              ++     +    G++L     L+    +     C A N  G K+
Sbjct: 1206 RGDAH----HISPDGVLLQ---VLQANLSSAGHYSCIAANAVGEKT 1244



 Score = 80.1 bits (196), Expect = 6e-15
 Identities = 89/371 (23%), Positives = 147/371 (39%), Gaps = 73/371 (19%)

Query: 130  SEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDN--CPELR---PELSWL--------- 175
            ++H  L ++  P I+   E  A  EV V+   P +  C  L    P ++W+         
Sbjct: 1244 TKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEAS 1303

Query: 176  -------GHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQF 228
                   G  GL    +L   +ED G +  V + + +     N H    +   P +  + 
Sbjct: 1304 RNIQLLPGTHGL---QILNAQKEDAGQYTCV-VTNELGEAVKNYH---VEVLIPPSISKD 1356

Query: 229  EGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLR-----EA 283
            +  A + VK           V+    S ++L C + + PPP + W +DG  +      + 
Sbjct: 1357 DPLAEVGVK----------EVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQV 1406

Query: 284  VAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVA------ 337
            + E  LL+++    ++ G Y C+A N  G+D++   + +   P    V     A      
Sbjct: 1407 LGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSR 1466

Query: 338  --------------VEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQ----LEL 379
                          VE     + C T + P P LT ++E Q LS     S LQ    L++
Sbjct: 1467 EEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQI 1526

Query: 380  PAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL------LLESHCAAARDTVQCLCV 433
            P V  E+ G Y C A N+ G+    + L V   PV+      L+E     A  TV   C 
Sbjct: 1527 PLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCP 1586

Query: 434  VKSNPEPSVAF 444
               NP P++++
Sbjct: 1587 ALGNPVPTISW 1597



 Score = 80.1 bits (196), Expect = 6e-15
 Identities = 87/368 (23%), Positives = 153/368 (41%), Gaps = 42/368 (11%)

Query: 149  VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSL----LHF 204
            V+ G EV + C      P   P+++WL     G P     L +D G  ++  L    L  
Sbjct: 1947 VLEGQEVRLDCEADGQPP---PDVAWLKD---GSP-----LGQDMGPHLRFYLDGGSLVL 1995

Query: 205  VPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVI---VEMNSSVEAIEGSHVSLLC 261
               R ++     C A   N   +     +++V  PP I    + + ++ +  G  V+++C
Sbjct: 1996 KGLRASDAGAYTCVAH--NPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVC 2053

Query: 262  GADSNPPPLLTWMRDGTVLREAVAESL-----LLELEEVTPAEDGVYACLAENAYGQDNR 316
                +PP  ++W++DG  L  +    L      L + +V  A+ G++ C+A +  G  +R
Sbjct: 2054 PVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADR 2113

Query: 317  TVGLSVMYAPWKPTVN--GTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESE 374
               L V   P    V     +V V G  V + C  +  P P+++  K+ + L +   E  
Sbjct: 2114 NFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQG 2173

Query: 375  LQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAAARDT----VQC 430
              L+L AV   D G Y CVA ++ G+    F L+V   P +           T    ++ 
Sbjct: 2174 PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMEL 2233

Query: 431  LCVVKSNPEPSVAFELPSRNVT--VNESEREFVYSERSGLVLTSIL---------TLRGQ 479
            LC  +  P+P++ +    + +T   N S    V   R   + T +          + R +
Sbjct: 2234 LCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVR 2293

Query: 480  AQAPPRVI 487
             QAPP ++
Sbjct: 2294 VQAPPNIV 2301



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 93/383 (24%), Positives = 141/383 (36%), Gaps = 51/383 (13%)

Query: 141  PNIVVPPE----VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTW 196
            P I +PP     V+  T V ++C      P   P L WL       PA    L+   G  
Sbjct: 695  PRITLPPSLPGPVLVNTPVRLTCNAT-GAPS--PTLMWLKDGNPVSPAGTPGLQVFPGGR 751

Query: 197  VQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSH 256
            V    L     R ++  R  C A   +   +      + V  PP I+    +V  +    
Sbjct: 752  V----LTLASARASDSGRYSCVAV--SAVGEDRQDVVLQVHMPPSILGEELNVSVVANES 805

Query: 257  VSLLCGADSNPPPLLTWMRDGTVLR-----EAVAESLLLELEEVTPAEDGVYACLAENAY 311
            V+L C + + PPP+L+W +DG  L         A+  LL+++     + G Y C A N  
Sbjct: 806  VALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQA 865

Query: 312  GQDNRTVGLSVMYAPWKP-TVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQIL---- 366
            G   +   L+V  AP  P   + T+   EG    + C  +  P P ++  K+ Q L    
Sbjct: 866  GHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEG 925

Query: 367  ---------STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL- 416
                       ++Y  + QL         +G Y C   N  G  +    L V   P +  
Sbjct: 926  AGLQHVSAVGRLLYLGQAQL-------AQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAG 978

Query: 417  ---LESHCAAARDTVQCL-CVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTS 472
                 +  +  +D V  L C     P P+V +E   + V         +  +  G    S
Sbjct: 979  PREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELG----LQLQNQG---QS 1031

Query: 473  ILTLRGQAQAPPRVICTARNLYG 495
            +   R QA    R  C A NL G
Sbjct: 1032 LHVERAQAAHTGRYSCVAENLAG 1054



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 63/229 (27%), Positives = 97/229 (42%), Gaps = 26/229 (11%)

Query: 236 VKYPPVIVEMNSS--VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-----VAESL 288
           V  PP I   N +  V  +E   V LLC A   P P +TW +DG +L  +          
Sbjct: 215 VHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGR 274

Query: 289 LLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNG------TMVAVEGET 342
            L+L     ++ GVY C A NA G   +   L V Y P  PT+ G       + AV G  
Sbjct: 275 QLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV-YVP--PTIEGAGGRPYVVKAVAGRP 331

Query: 343 VSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGE-----YWCVAENQ 397
           V++ C  + +P P L+ +  + +      ES L+ +   +  E  GE     Y CVA + 
Sbjct: 332 VALECVARGHPSPTLS-WHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSP 390

Query: 398 YGQRATAFNLSVEFAPVLLLESHCAAARDTV----QCLCVVKSNPEPSV 442
            G+    +++ V+  P LL+          V    +  C    +P P++
Sbjct: 391 AGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTI 439



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 95/381 (24%), Positives = 143/381 (37%), Gaps = 53/381 (13%)

Query: 134  VLDIVNTPNIVVPPEVVAGTEVEVSCM---VPDNCPELRPELSWLGHEGLGEPAVLGRLR 190
            VL+ V   N VV   VV G+ VE+ C    VP       P +SW+     GEP +   L 
Sbjct: 2124 VLEPVEFQNDVV---VVRGSLVELPCEARGVP------LPLVSWMKD---GEPLLSQSLE 2171

Query: 191  EDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYA----SMDVKYPPVIVEMN 246
            +              P+ +      G   ++    +   G A     + V  PP I +  
Sbjct: 2172 QG-------------PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSG 2218

Query: 247  SSVEA--IEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDGVYA 304
               E     G+ + LLC A   P P +TW +DG  L      S    +  V  A  G+Y 
Sbjct: 2219 QPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDA--GLYT 2276

Query: 305  CLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAV---EGETVSILCSTQSNPDPILTIFK 361
            CLAE+  G   ++  + V   P      G    V    G+ V + CS ++ P P +T  +
Sbjct: 2277 CLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLV-LECSVEAEPAPKITWHR 2335

Query: 362  EKQILS----TVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLL 417
            +  +L     T   E    L+L A+S  D G+Y C A N  G  + AF + +   P +  
Sbjct: 2336 DGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRS 2395

Query: 418  ESHC--AAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILT 475
                   +   T    C     P P V++      V ++     F       L +  +L 
Sbjct: 2396 GPPAVNVSVNQTALLPCQADGVPAPLVSWR--KDRVPLDPRSPRFEILPEGSLRIQPVL- 2452

Query: 476  LRGQAQAPPRVICTARNLYGA 496
                AQ     +C A N  G+
Sbjct: 2453 ----AQDAGHYLCLASNSAGS 2469



 Score = 69.7 bits (169), Expect = 8e-12
 Identities = 50/200 (25%), Positives = 86/200 (43%), Gaps = 20/200 (10%)

Query: 233  SMDVKYPPVIVEMNS-SVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-- 289
            ++ V+ PP      + +V  + GS + L C     P P +TW++D   +  +    ++  
Sbjct: 1835 TLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSR 1894

Query: 290  ---LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVA-----VEGE 341
               L+L  + PA+ G Y C+AEN   +  +   ++V+ A   P +  + VA     +EG+
Sbjct: 1895 GGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVA---PRIRSSGVAREHHVLEGQ 1951

Query: 342  TVSILCSTQSNPDPILTIFKEKQILSTVI------YESELQLELPAVSPEDDGEYWCVAE 395
             V + C     P P +   K+   L   +      Y     L L  +   D G Y CVA 
Sbjct: 1952 EVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAH 2011

Query: 396  NQYGQRATAFNLSVEFAPVL 415
            N  G+ A    ++V   P +
Sbjct: 2012 NPAGEDARLHTVNVLVPPTI 2031



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 64/291 (21%), Positives = 117/291 (40%), Gaps = 27/291 (9%)

Query: 141  PNIVVP--PEVVAGT---EVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGT 195
            PNIV P  P  V G    ++ + C V     E  P+++W   +G+           + G 
Sbjct: 2298 PNIVGPRGPRFVVGLAPGQLVLECSVE---AEPAPKITW-HRDGIVLQEDAHTQFPERGR 2353

Query: 196  WVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGS 255
            ++Q+  L    T ++  +    + +  +T++ F     +++   P I     +V      
Sbjct: 2354 FLQLQALS---TADSGDYSCTARNAAGSTSVAFR----VEIHTVPTIRSGPPAVNVSVNQ 2406

Query: 256  HVSLLCGADSNPPPLLTWMRDGTVL-----REAVAESLLLELEEVTPAEDGVYACLAENA 310
               L C AD  P PL++W +D   L     R  +     L ++ V   + G Y CLA N+
Sbjct: 2407 TALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNS 2466

Query: 311  YGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVI 370
             G D +   L V+  P        +         + C    +P P++  +K+ Q L   +
Sbjct: 2467 AGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRL 2526

Query: 371  YESELQ------LELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL 415
             +   +      L L A  P+D  ++ CV  N+ G+    + ++V   P +
Sbjct: 2527 QQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTI 2577



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 53/201 (26%), Positives = 84/201 (41%), Gaps = 15/201 (7%)

Query: 254  GSHVSLLCGADSNPPPLLTWMRDGTVLREAVAES---LLLELEEVTPAEDGVYACLAENA 310
            G  + L C A  +P P + W  +   + E V+E      L+   V+  + G Y C AEN 
Sbjct: 2861 GDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENR 2920

Query: 311  YGQDNRTVGLSVMYAPWKPTVNGT----MVAVEGETVSILCSTQSNPDPILTIFKEKQIL 366
             G   RT  +S ++    P + G     +V   G ++ + C  + +P P +   K+   L
Sbjct: 2921 VG---RTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPL 2977

Query: 367  STVIYESELQ---LELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAA 423
                   +LQ   L +     +D G Y C+AEN+ G       L ++ APV  +E     
Sbjct: 2978 RGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMT 3037

Query: 424  AR--DTVQCLCVVKSNPEPSV 442
             R  D V   C     P P++
Sbjct: 3038 VRSGDDVALRCQATGEPTPTI 3058



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 80/322 (24%), Positives = 123/322 (38%), Gaps = 43/322 (13%)

Query: 150 VAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVS----LLHFV 205
           + G  +E+ C    +     P + WL +   G PA       +E   VQV+     LH  
Sbjct: 420 IVGQPLELPCQASGSPV---PTIQWLQN---GRPA-------EELAGVQVASQGTTLHID 466

Query: 206 PTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEM-----------NSSVEAIEG 254
                +     CQA+    T   E   S+  ++ P ++E+           +SS  A   
Sbjct: 467 HVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACD 526

Query: 255 SHVSLLCGADSNPPPLLTWMRDGTVLREA----VAESLL--LELEEVTPAEDGVYACLAE 308
             V    GA   PP +  W   G++  E     VA SL   L++E+V   ++G+Y C A 
Sbjct: 527 PPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAAT 586

Query: 309 NAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILS- 367
           N  G+  R V L V+  P           +E  +V++ C     P P ++ FK  Q +S 
Sbjct: 587 NLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSS 646

Query: 368 ----TVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHC-- 421
               TV  +  + L +      D G Y CVA N  G     + L V   P + L      
Sbjct: 647 WMGVTVSVDGRV-LRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPG 705

Query: 422 -AAARDTVQCLCVVKSNPEPSV 442
                  V+  C     P P++
Sbjct: 706 PVLVNTPVRLTCNATGAPSPTL 727



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 62/248 (25%), Positives = 96/248 (38%), Gaps = 51/248 (20%)

Query: 239 PPVIVE--MNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVL---------------- 280
           PP I E    ++V  + G  ++L C A+  P P + W++D  ++                
Sbjct: 16  PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWG 75

Query: 281 ----REAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMV 336
                  + E   L    +   + G+Y+C AEN  G   R   L V+  P   +V G   
Sbjct: 76  QVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPP---SVLGAGA 132

Query: 337 AVE-----GETVSILCSTQSNPDPILTIFKEKQIL-----STVIYESELQLELPAVSPED 386
           A E     G  V + C T   P P +   K++Q +        + E    L +      D
Sbjct: 133 AQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGD 192

Query: 387 DGEYWCVAENQYGQRATAFNLSVEFAP----------VLLLESHCAAARDTVQCLCVVKS 436
           +G Y CVA +  GQ+A  F L V   P          V ++E H       VQ LC  + 
Sbjct: 193 EGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDH------LVQLLCEARG 246

Query: 437 NPEPSVAF 444
            P P++ +
Sbjct: 247 VPTPNITW 254



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 81/332 (24%), Positives = 128/332 (38%), Gaps = 54/332 (16%)

Query: 148 EVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPT 207
           + VAG  V + C+   +     P LSW  HEGL          E +G     S+L     
Sbjct: 325 KAVAGRPVALECVARGHPS---PTLSW-HHEGLPVAESNESRLETDG-----SVLRLESP 375

Query: 208 REANGHRLGCQASFP--NTTLQFEGYASMDVKYPP--VIVEMNSSVEAIEGSHVSLLCGA 263
            EA+     C AS P     LQ+    S++V+ PP  ++ E    V  I G  + L C A
Sbjct: 376 GEASSGLYSCVASSPAGEAVLQY----SVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQA 431

Query: 264 DSNPPPLLTWMRDGTVLRE-----AVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTV 318
             +P P + W+++G    E       ++   L ++ V     G++AC A N  G     V
Sbjct: 432 SGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEV 491

Query: 319 GLSVMYAPWKPTVNGTMVA------VEGETVSILCSTQ------SNPDPIL--------T 358
            +SV +  W P V    +           +    C         ++P P L        +
Sbjct: 492 EVSV-HGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGS 550

Query: 359 IFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQ--RATAFNL----SVEFA 412
           ++ E   +  V Y     L++  V   D+G Y C A N  G+  R  A  +    ++E  
Sbjct: 551 LWGEPTGI-PVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPG 609

Query: 413 PVLLLESHCAAARDTVQCLCVVKSNPEPSVAF 444
           PV    +       +V   C+    P P V++
Sbjct: 610 PV----NKAVLENASVTLECLASGVPPPDVSW 637



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 68/255 (26%), Positives = 102/255 (40%), Gaps = 24/255 (9%)

Query: 170  PELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFE 229
            P + W  ++    P   G   +D G+ +Q + +    +RE +G  + C A   N   + +
Sbjct: 2876 PRIGWTVND---RPVTEGVSEQDGGSTLQRAAV----SREDSGTYV-CWAE--NRVGRTQ 2925

Query: 230  GYASMDVKYPPVIVEMNSS--VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAES 287
              + + VK  PV+     S  VE + GS + L C    +P P + W++DG  LR +    
Sbjct: 2926 AVSFVHVKEAPVLQGEAFSYLVEPVGGS-IQLDCVVRGDPVPDIHWIKDGLPLRGSHLRH 2984

Query: 288  LL----LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETV 343
             L    L +      + G Y CLAEN  G   + V L +  AP        M    G+ V
Sbjct: 2985 QLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDV 3044

Query: 344  SILCSTQSNPDPILTIFKEKQILST-----VIYESELQLELPAVSPEDDGEYWCVAENQY 398
            ++ C     P P +   +  Q L        + +  L LE   V   D G Y CVA N  
Sbjct: 3045 ALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLE--NVETGDAGTYDCVAHNLL 3102

Query: 399  GQRATAFNLSVEFAP 413
            G       L V   P
Sbjct: 3103 GSATARAFLVVRGEP 3117



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 54/231 (23%), Positives = 83/231 (35%), Gaps = 13/231 (5%)

Query: 239  PPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAE-------SLLLE 291
            PP I    S++     +   L C A  +P PL+ W +DG  L   + +       S  L 
Sbjct: 2481 PPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALL 2540

Query: 292  LEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQS 351
            L    P +   + C+  N  G+ +R   ++V   P                V + C +  
Sbjct: 2541 LTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTG 2600

Query: 352  NPDPILTIFKEKQIL----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNL 407
             P P ++  K    L    S         LE+    P   G Y C A N  G       L
Sbjct: 2601 IPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFL 2660

Query: 408  SVEFAPVL--LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNES 456
            +V+ +PV+  L     A A + V   C     P P++ ++    NV    S
Sbjct: 2661 TVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVS 2711


>gi|130979981 CD33 antigen isoform 1 precursor [Homo sapiens]
          Length = 364

 Score = 93.6 bits (231), Expect = 5e-19
 Identities = 75/249 (30%), Positives = 101/249 (40%), Gaps = 23/249 (9%)

Query: 1   MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFP----DELRPAVVH 56
           M  L  LPL W    A     W   +  S++  EG CV +PC F  P    D+  P  VH
Sbjct: 1   MPLLLLLPLLWAGALAMDPNFW-LQVQESVTVQEGLCVLVPCTFFHPIPYYDKNSP--VH 57

Query: 57  GVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYY 116
           G W+          PV      Q V E  QGR RLLGD    NC+L + +      G Y+
Sbjct: 58  GYWFREGAIISRDSPVATNKLDQEVQEETQGRFRLLGDPSRNNCSLSIVDARRRDNGSYF 117

Query: 117 FRGDLG----GYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPEL 172
           FR + G     Y     S H V D+ + P I++P  +  G    ++C V   C +  P +
Sbjct: 118 FRMERGSTKYSYKSPQLSVH-VTDLTHRPKILIPGTLEPGHSKNLTCSVSWACEQGTPPI 176

Query: 173 -SWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGY 231
            SWL       P  LG            S+L   P  + +G  L CQ  F    +  E  
Sbjct: 177 FSWLS----AAPTSLG------PRTTHSSVLIITPRPQDHGTNLTCQVKFAGAGVTTERT 226

Query: 232 ASMDVKYPP 240
             ++V Y P
Sbjct: 227 IQLNVTYVP 235


>gi|109150416 peroxidasin [Homo sapiens]
          Length = 1479

 Score = 90.1 bits (222), Expect = 5e-18
 Identities = 103/384 (26%), Positives = 151/384 (39%), Gaps = 45/384 (11%)

Query: 141 PNIVVPPE---VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLRE-DEGTW 196
           P I   P+   V +G  V  +C    N    +PE+ WL +          RL   D+GT 
Sbjct: 246 PRITSEPQDADVTSGNTVYFTCRAEGNP---KPEIIWLRNNNELSMKTDSRLNLLDDGT- 301

Query: 197 VQVSLLHFVPTREANGHRLGCQAS-------FPNTTLQFEGYASMDVKYPPVIVEMNSSV 249
                L    T+E +     C A            TL++ G  +      P  V    + 
Sbjct: 302 -----LMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPAR-----PTFVIQPQNT 351

Query: 250 EAIEGSHVSLLCGADSNPPPLLTWMR-DGTVL----REAVAESLLLELEEVTPAEDGVYA 304
           E + G  V+L C A  +PPP ++W R D T L    R  +  S  L ++ V   + G YA
Sbjct: 352 EVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYA 411

Query: 305 CLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQ 364
           C A N     + T  + V   P         V +EG+TV   C  + NP P++   K   
Sbjct: 412 CSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGS 471

Query: 365 ILST---VIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVE--FAPVL--LL 417
            LS     +  S   L +  V+  D G+Y C A N  G +    +L+V+    PV   + 
Sbjct: 472 QLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIP 531

Query: 418 ESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLR 477
                     VQ  C  +  PEP++ +      V V ES + F  S    L +  +    
Sbjct: 532 SDTTVEVGANVQLPCSSQGEPEPAITWN--KDGVQVTESGK-FHISPEGFLTINDV---- 584

Query: 478 GQAQAPPRVICTARNLYGAKSLEL 501
           G A A  R  C ARN  G+ S+ +
Sbjct: 585 GPADA-GRYECVARNTIGSASVSM 607



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 73/287 (25%), Positives = 109/287 (37%), Gaps = 25/287 (8%)

Query: 141 PNIVVPP---EVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPA-VLGRLREDEGTW 196
           P  V+ P   EV+ G  V + C    + P   P +SW   +    P      +    G +
Sbjct: 342 PTFVIQPQNTEVLVGESVTLECSATGHPP---PRISWTRGDRTPLPVDPRVNITPSGGLY 398

Query: 197 VQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSH 256
           +Q  +       + +     C A+  N        A + V+  P           IEG  
Sbjct: 399 IQNVV-------QGDSGEYACSAT--NNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQT 449

Query: 257 VSLLCGADSNPPPLLTWMRDGTVL----REAVAESLLLELEEVTPAEDGVYACLAENAYG 312
           V   C A  NPPP++ W + G+ L    R  V  S  L +  V   + G Y C A N  G
Sbjct: 450 VDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIG 509

Query: 313 QDNRTVGLSVM--YAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEK-QILSTV 369
                  L+V     P   ++        G  V + CS+Q  P+P +T  K+  Q+  + 
Sbjct: 510 SQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESG 569

Query: 370 IYESELQ--LELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPV 414
            +    +  L +  V P D G Y CVA N  G  + +  LSV    V
Sbjct: 570 KFHISPEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSVNVPDV 616


>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
          Length = 1215

 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 93/374 (24%), Positives = 151/374 (40%), Gaps = 29/374 (7%)

Query: 137 IVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTW 196
           +V  PN+ V P    G    +SC V    P     L+W+  +    PA  GR+ +     
Sbjct: 403 LVPAPNVTVSP----GETAVLSCRVLGEAPY---NLTWV-RDWRVLPASTGRVAQLADLS 454

Query: 197 VQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSH 256
           +++S +  +PT   +G R  C AS  N   +   +  + V+  P +    SS    +G  
Sbjct: 455 LEISGI--IPT---DGGRYQCVASNANGVTRASVW--LLVREAPQVSIHTSSQHFSQGVE 507

Query: 257 VSLLCGADSNPPPLLTWMRDGTVLREA----VAESLLLELEEVTPAEDGVYACLAENAYG 312
           V + C A   P P ++W R+   L+E     V     L ++ V P + G Y+C A N  G
Sbjct: 508 VKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVG 567

Query: 313 QDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFK-EKQILSTVIY 371
            D  TV L     P    VN  ++   GE   ++C     P P +  ++   +++     
Sbjct: 568 TDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEG 627

Query: 372 ESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL--LLESHCAAARDTVQ 429
            S  +L +PA    D G Y C A N+ G  +    L+V  AP L  L          +  
Sbjct: 628 SSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSAL 687

Query: 430 CLCVVKSNPEPSVAF---ELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQAQAPPRV 486
             C     P P+V +   +     + +            SG++     ++  + QAP   
Sbjct: 688 LACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFE--SVAPEDQAP--Y 743

Query: 487 ICTARNLYGAKSLE 500
           +C ARN++G    E
Sbjct: 744 VCEARNVFGKVQAE 757



 Score = 76.3 bits (186), Expect = 8e-14
 Identities = 95/371 (25%), Positives = 134/371 (36%), Gaps = 34/371 (9%)

Query: 149  VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTR 208
            V  G    ++C      P   P ++W   +G      LG  R          +L F    
Sbjct: 680  VELGRSALLACRATGRPP---PTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVA 736

Query: 209  EANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPP 268
              +     C+A      +Q E    +    PP I     +V  +EG  VSL C   +  P
Sbjct: 737  PEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRP 796

Query: 269  -PLLTWMRDGTVL----REAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVM 323
             P   W++DG  L    R ++     L L+       G Y+C+A N  G  +R V L V 
Sbjct: 797  LPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQ 856

Query: 324  YAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILST------VIYESELQL 377
              P         +  EG   S+ C     P P +T  KE   L++      V  E  L +
Sbjct: 857  VPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLI 916

Query: 378  ELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESH---------CAAARDTV 428
              P  S +D G Y C A N  G  +    LSV   P + +             A A + V
Sbjct: 917  AQP--SAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEV 974

Query: 429  QCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTL-RGQAQAPPRVI 487
               C  K +P P V +   SR V           + R GL+ +  L L + Q        
Sbjct: 975  TLDCEAKGSPPPLVTWTKDSRPVP--------PITNRYGLLPSGSLRLAQVQVGDSGHYE 1026

Query: 488  CTARNLYGAKS 498
            CTA N  G+ S
Sbjct: 1027 CTASNPAGSAS 1037



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 55/176 (31%), Positives = 77/176 (43%), Gaps = 8/176 (4%)

Query: 232 ASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVL-----REAVAE 286
           A + V  PP  +    +V    G    L C      P  LTW+RD  VL     R A   
Sbjct: 392 AQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLA 451

Query: 287 SLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSIL 346
            L LE+  + P + G Y C+A NA G    +V L V  AP       +    +G  V + 
Sbjct: 452 DLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVS 511

Query: 347 CSTQSNPDPILTIFKEKQIL---STVIYESELQLELPAVSPEDDGEYWCVAENQYG 399
           CS    P P ++  +E Q L   S +  +++  L +  V+PED G Y C A N+ G
Sbjct: 512 CSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVG 567



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 71/279 (25%), Positives = 110/279 (39%), Gaps = 29/279 (10%)

Query: 149  VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTR 208
            V+ G  V + C+V    P   PE  WL       P     +R D         LH     
Sbjct: 779  VLEGQPVSLPCIVLAGRP--LPERHWLKDGRPLPPGSRHSIRADGS-------LHLDRAL 829

Query: 209  EANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPP 268
            + +  R  C A+  NT         + V+ PP I    +     EG   SL C A   P 
Sbjct: 830  QEHAGRYSCVAT--NTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPA 887

Query: 269  PLLTWMRDGTVLREA-----VAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVM 323
            P +TW ++   L        V++   L + + +  + G Y C A N  G  ++ + LSV 
Sbjct: 888  PTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVN 947

Query: 324  YAPWKPTVNGT--------MVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESEL 375
              P +  +NG+        + A  GE V++ C  + +P P++T  K+ + +  +     L
Sbjct: 948  TKP-RIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGL 1006

Query: 376  ----QLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVE 410
                 L L  V   D G Y C A N  G  +  + L V+
Sbjct: 1007 LPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQ 1045



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 40/165 (24%), Positives = 65/165 (39%), Gaps = 6/165 (3%)

Query: 291 ELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQ 350
           E+   + AE+G Y C A +  G       + V   P +      +    GET  + C   
Sbjct: 365 EILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL 424

Query: 351 SNPDPILTIFKEKQIL----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFN 406
                 LT  ++ ++L      V   ++L LE+  + P D G Y CVA N  G    +  
Sbjct: 425 GEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVW 484

Query: 407 LSVEFAPVLLL--ESHCAAARDTVQCLCVVKSNPEPSVAFELPSR 449
           L V  AP + +   S   +    V+  C     P P +++   S+
Sbjct: 485 LLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQ 529



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 29/87 (33%), Positives = 39/87 (44%), Gaps = 6/87 (6%)

Query: 249  VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVL-----REAVAESLLLELEEVTPAEDGVY 303
            V A  G  V+L C A  +PPPL+TW +D   +     R  +  S  L L +V   + G Y
Sbjct: 966  VTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHY 1025

Query: 304  ACLAENAYGQDNRTVGLSVM-YAPWKP 329
             C A N  G  +    L V     W+P
Sbjct: 1026 ECTASNPAGSASHRYVLGVQGRTSWQP 1052


>gi|4507875 vascular cell adhesion molecule 1 isoform a precursor
           [Homo sapiens]
          Length = 739

 Score = 86.7 bits (213), Expect = 6e-17
 Identities = 95/366 (25%), Positives = 152/366 (41%), Gaps = 31/366 (8%)

Query: 74  FKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYNQYTFSEHS 133
           F  RTQ+      G+ R  G     N TL LS VS E    Y      G        +  
Sbjct: 345 FSWRTQI-DSPLSGKVRSEGT----NSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVE 399

Query: 134 VLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDE 193
           +      P I +   +V G+ V VSC VP   P  R E+  L  E + E        + +
Sbjct: 400 LYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMK 459

Query: 194 GTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEG---------YASMDVKYPPVIVE 244
               +   + F+PT E  G  L CQA      ++FE          Y ++  +   V+V 
Sbjct: 460 SLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVS 519

Query: 245 MNSSVEAIEGSHVSLLCGADSNPPPLLTWMR---DGTVLREAVAESLLLELEEVTPAEDG 301
            +S +E  EGS V++ C +   P P + W R   +G +  + ++E+  L L      + G
Sbjct: 520 PSSILE--EGSSVNMTCLSQGFPAPKILWSRQLPNGEL--QPLSENATLTLISTKMEDSG 575

Query: 302 VYACLAENAYGQDNRTVGLSVMYAPW--KPTVNGTMVAVEGETVSILCSTQSNPDPILTI 359
           VY C   N  G+  + V L +   P   K T   +    EG+TV I C+  + P+  + +
Sbjct: 576 VYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIIL 635

Query: 360 FKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVE--------F 411
            K+ +   TV+   +    +     +D G Y C ++N+ G +  +  L V+        F
Sbjct: 636 KKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYF 695

Query: 412 APVLLL 417
           +P LL+
Sbjct: 696 SPELLV 701



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 51/227 (22%), Positives = 93/227 (40%), Gaps = 14/227 (6%)

Query: 141 PNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVS 200
           P I +   + AG  + V C V D  P  R E+  L  + L +        + +    +  
Sbjct: 119 PEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSL 178

Query: 201 LLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPV-------IVEMNSSVEAIE 253
            + F P  E  G  L C+A      +         VK   V       ++ +N S +  E
Sbjct: 179 EVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQE 238

Query: 254 GSHVSLLCGADSNPPPLLTWMR---DGTVLREAVAESLLLELEEVTPAEDGVYACLAENA 310
           G  V++ C ++  P P + W +   +G +  + ++ +  L L  +   + G+Y C   N 
Sbjct: 239 GGSVTMTCSSEGLPAPEIFWSKKLDNGNL--QHLSGNATLTLIAMRMEDSGIYVCEGVNL 296

Query: 311 YGQDNRTVGLSVMYAPWKPTVN-GTMVAVE-GETVSILCSTQSNPDP 355
            G++ + V L V   P+   ++ G  +A + G++V + CS      P
Sbjct: 297 IGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESP 343



 Score = 34.7 bits (78), Expect = 0.27
 Identities = 31/119 (26%), Positives = 48/119 (40%), Gaps = 4/119 (3%)

Query: 330 TVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGE 389
           +VN +    EG +V++ CS++  P P +   K+    +         L L A+  ED G 
Sbjct: 229 SVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGI 288

Query: 390 YWCVAENQYGQRATAFNLSVEFAPVLLLESH----CAAARDTVQCLCVVKSNPEPSVAF 444
           Y C   N  G+      L V+  P  +  S      A   D+V   C V     PS ++
Sbjct: 289 YVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSW 347


>gi|18201909 vascular cell adhesion molecule 1 isoform b precursor
           [Homo sapiens]
          Length = 647

 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 91/342 (26%), Positives = 147/342 (42%), Gaps = 28/342 (8%)

Query: 99  NCTLLLSNVSPELGGKYYFRG-DLGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEV 157
           N TL L  +  E  G Y   G +L G N+    E  V      P I +   +V G+ V V
Sbjct: 273 NATLTLIAMRMEDSGIYVCEGVNLIGKNRKEV-ELIVQAFPRDPEIEMSGGLVNGSSVTV 331

Query: 158 SCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGC 217
           SC VP   P  R E+  L  E + E        + +    +   + F+PT E  G  L C
Sbjct: 332 SCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVC 391

Query: 218 QASFPNTTLQFEG---------YASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPP 268
           QA      ++FE          Y ++  +   V+V  +S +E  EGS V++ C +   P 
Sbjct: 392 QAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILE--EGSSVNMTCLSQGFPA 449

Query: 269 PLLTWMR---DGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYA 325
           P + W R   +G +  + ++E+  L L      + GVY C   N  G+  + V L +   
Sbjct: 450 PKILWSRQLPNGEL--QPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVT 507

Query: 326 PW--KPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVS 383
           P   K T   +    EG+TV I C+  + P+  + + K+ +   TV+   +    +    
Sbjct: 508 PKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQ 567

Query: 384 PEDDGEYWCVAENQYGQRATAFNLSVE--------FAPVLLL 417
            +D G Y C ++N+ G +  +  L V+        F+P LL+
Sbjct: 568 LKDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLV 609



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 111/506 (21%), Positives = 197/506 (38%), Gaps = 61/506 (12%)

Query: 141 PNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVS 200
           P I +   + AG  + V C V D  P  R E+  L  + L +        + +    +  
Sbjct: 119 PEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSL 178

Query: 201 LLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPV-------IVEMNSSVEAIE 253
            + F P  E  G  L C+A      +         VK   V       ++ +N S +  E
Sbjct: 179 EVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQE 238

Query: 254 GSHVSLLCGADSNPPPLLTWMR---DGTVLREAVAESLLLELEEVTPAEDGVYACLAENA 310
           G  V++ C ++  P P + W +   +G +  + ++ +  L L  +   + G+Y C   N 
Sbjct: 239 GGSVTMTCSSEGLPAPEIFWSKKLDNGNL--QHLSGNATLTLIAMRMEDSGIYVCEGVNL 296

Query: 311 YGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPI----LTIFKEKQIL 366
            G++ + V L V   P  P +  +   V G +V++ C   S   P+    + + K + IL
Sbjct: 297 IGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPS-VYPLDRLEIELLKGETIL 355

Query: 367 STVIYESELQLE-----------LPAVSPEDDGE-YWCVA-------ENQYGQRATAFNL 407
             + +  +  ++           +P +  ED G+   C A       E +  QR +   L
Sbjct: 356 ENIEFLEDTDMKSLENKSLEMTFIPTI--EDTGKALVCQAKLHIDDMEFEPKQRQSTQTL 413

Query: 408 SVEFAP----VLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYS 463
            V  AP    VL+  S       +V   C+ +  P P +   L SR +   E +     S
Sbjct: 414 YVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKI---LWSRQLPNGELQ---PLS 467

Query: 464 ERSGLVLTSILTLRGQAQAPPRVICTARNLYG--AKSLELPFQGAHRLMWAKIGPVGAV- 520
           E + L L S      + +     +C   N  G   K +EL  Q   + +     P  +V 
Sbjct: 468 ENATLTLIST-----KMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVK 522

Query: 521 VAFAILIAIVC-YITQT---RRKKNVTESPSFSAGDNPPVLFSSDFRISGAPEKYESERR 576
               ++I+  C  + +T    +KK  T      + D    +  +  + +G  E  ES+ +
Sbjct: 523 EGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYE-CESKNK 581

Query: 577 LGSERRLLGLRGEPPELDLSYSHSDL 602
           +GS+ R L L  +  E +  Y   +L
Sbjct: 582 VGSQLRSLTLDVQGRENNKDYFSPEL 607


>gi|145275174 kin of IRRE-like 2 isoform c [Homo sapiens]
          Length = 708

 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 122/467 (26%), Positives = 179/467 (38%), Gaps = 44/467 (9%)

Query: 142 NIVVPPE---VVAGTEVEVSCMVPDNCP-------ELRPELSWLGHEGLGEPAVLGRLRE 191
           +++VPPE   V+ G  V +   VP N            PEL W     L + A   +   
Sbjct: 118 HVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLL 177

Query: 192 DEGTWVQV-SLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVE 250
            EGT   V S L   P    +G    C+A         +   ++ ++YPP +    S   
Sbjct: 178 KEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHT 237

Query: 251 AIEGSHVSLLCGADSNPPPL-LTWMRDGTVLREAVAESLLLELEEVTPAEDGVYACLAEN 309
             EG  V  LC A + PP     W + G+ +  A    L +  +     E    +C   N
Sbjct: 238 VQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEP--VSCEVSN 295

Query: 310 AYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTV 369
           A G  NR+  L V++ P        +    GE  S  C+ + NP P +T  +        
Sbjct: 296 AVGSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG---GAQ 352

Query: 370 IYESELQLELPAVSPEDDGEYWCVAE-NQYGQR--ATAFNLSVEFAPVL-LLESHCAAAR 425
           +  S   L LP+V PED G+Y C AE    G R  A    L+V   PV+  L S  A  R
Sbjct: 353 VLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLR 412

Query: 426 DTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVY------SERSGL--VLTSILTLR 477
              +  C+V ++P P               S+  F+         R GL   L S+L + 
Sbjct: 413 GPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHIS 472

Query: 478 G--QAQAPPRVICTARNLYGAKSLELPFQGAHRLMWAKI--GPVGAVVAFAILI---AIV 530
           G  ++       C+ARN  G    +        L   +I  G   A     ++I   A+ 
Sbjct: 473 GTQESDFSRSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALC 532

Query: 531 CYITQTRRKKNVTESPSFSAGDN-PPVLFSSDFRISGAPEKYESERR 576
           C+       ++   S SFS   N   +  SSD   S  PE+ E+  R
Sbjct: 533 CW-------RHSKASASFSEQKNLMRIPGSSDGSSSRGPEEEETGSR 572


>gi|145275172 kin of IRRE-like 2 isoform b [Homo sapiens]
          Length = 583

 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 122/467 (26%), Positives = 179/467 (38%), Gaps = 44/467 (9%)

Query: 142 NIVVPPE---VVAGTEVEVSCMVPDNCP-------ELRPELSWLGHEGLGEPAVLGRLRE 191
           +++VPPE   V+ G  V +   VP N            PEL W     L + A   +   
Sbjct: 68  HVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLL 127

Query: 192 DEGTWVQV-SLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVE 250
            EGT   V S L   P    +G    C+A         +   ++ ++YPP +    S   
Sbjct: 128 KEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHT 187

Query: 251 AIEGSHVSLLCGADSNPPPL-LTWMRDGTVLREAVAESLLLELEEVTPAEDGVYACLAEN 309
             EG  V  LC A + PP     W + G+ +  A    L +  +     E    +C   N
Sbjct: 188 VQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEP--VSCEVSN 245

Query: 310 AYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTV 369
           A G  NR+  L V++ P        +    GE  S  C+ + NP P +T  +        
Sbjct: 246 AVGSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG---GAQ 302

Query: 370 IYESELQLELPAVSPEDDGEYWCVAE-NQYGQR--ATAFNLSVEFAPVL-LLESHCAAAR 425
           +  S   L LP+V PED G+Y C AE    G R  A    L+V   PV+  L S  A  R
Sbjct: 303 VLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLR 362

Query: 426 DTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVY------SERSGL--VLTSILTLR 477
              +  C+V ++P P               S+  F+         R GL   L S+L + 
Sbjct: 363 GPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHIS 422

Query: 478 G--QAQAPPRVICTARNLYGAKSLELPFQGAHRLMWAKI--GPVGAVVAFAILI---AIV 530
           G  ++       C+ARN  G    +        L   +I  G   A     ++I   A+ 
Sbjct: 423 GTQESDFSRSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALC 482

Query: 531 CYITQTRRKKNVTESPSFSAGDN-PPVLFSSDFRISGAPEKYESERR 576
           C+       ++   S SFS   N   +  SSD   S  PE+ E+  R
Sbjct: 483 CW-------RHSKASASFSEQKNLMRIPGSSDGSSSRGPEEEETGSR 522


>gi|145275170 kin of IRRE-like 2 isoform a [Homo sapiens]
          Length = 633

 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 122/467 (26%), Positives = 179/467 (38%), Gaps = 44/467 (9%)

Query: 142 NIVVPPE---VVAGTEVEVSCMVPDNCP-------ELRPELSWLGHEGLGEPAVLGRLRE 191
           +++VPPE   V+ G  V +   VP N            PEL W     L + A   +   
Sbjct: 118 HVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLL 177

Query: 192 DEGTWVQV-SLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVE 250
            EGT   V S L   P    +G    C+A         +   ++ ++YPP +    S   
Sbjct: 178 KEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHT 237

Query: 251 AIEGSHVSLLCGADSNPPPL-LTWMRDGTVLREAVAESLLLELEEVTPAEDGVYACLAEN 309
             EG  V  LC A + PP     W + G+ +  A    L +  +     E    +C   N
Sbjct: 238 VQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEP--VSCEVSN 295

Query: 310 AYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTV 369
           A G  NR+  L V++ P        +    GE  S  C+ + NP P +T  +        
Sbjct: 296 AVGSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG---GAQ 352

Query: 370 IYESELQLELPAVSPEDDGEYWCVAE-NQYGQR--ATAFNLSVEFAPVL-LLESHCAAAR 425
           +  S   L LP+V PED G+Y C AE    G R  A    L+V   PV+  L S  A  R
Sbjct: 353 VLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLR 412

Query: 426 DTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVY------SERSGL--VLTSILTLR 477
              +  C+V ++P P               S+  F+         R GL   L S+L + 
Sbjct: 413 GPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHIS 472

Query: 478 G--QAQAPPRVICTARNLYGAKSLELPFQGAHRLMWAKI--GPVGAVVAFAILI---AIV 530
           G  ++       C+ARN  G    +        L   +I  G   A     ++I   A+ 
Sbjct: 473 GTQESDFSRSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALC 532

Query: 531 CYITQTRRKKNVTESPSFSAGDN-PPVLFSSDFRISGAPEKYESERR 576
           C+       ++   S SFS   N   +  SSD   S  PE+ E+  R
Sbjct: 533 CW-------RHSKASASFSEQKNLMRIPGSSDGSSSRGPEEEETGSR 572


>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
           sapiens]
          Length = 1248

 Score = 83.6 bits (205), Expect = 5e-16
 Identities = 99/376 (26%), Positives = 154/376 (40%), Gaps = 44/376 (11%)

Query: 144 VVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEG-TWVQVSLL 202
           V P EV  G  V + C  P +   LR  + W+  + L        +++DE  T  Q   L
Sbjct: 138 VKPVEVEEGESVVLPCNPPPSAEPLR--IYWMNSKIL-------HIKQDERVTMGQNGNL 188

Query: 203 HFVPTREANGHR-LGCQASFPNTT---------LQFEGYASMDVKYPPVIVEMNSS--VE 250
           +F     ++ H    C A FP T          L+ +   SM  + P ++   NSS  + 
Sbjct: 189 YFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLV 248

Query: 251 AIEGSHVSLLCGADSNPPPLLTWMR-DGTVLREAVA---ESLLLELEEVTPAEDGVYACL 306
           A++G  + L C A+  P P + W+R  G +  + V     +  L+L +V   +DG Y CL
Sbjct: 249 ALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCL 308

Query: 307 AENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQIL 366
           AEN+ G       ++V  AP+      + +   GET  + C  Q  P P +T       +
Sbjct: 309 AENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPV 368

Query: 367 STVIYESELQLE-----LPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLL---- 417
             +  + + +++     L  V P D     C A N++G       + V   P  +L    
Sbjct: 369 EELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADN 428

Query: 418 ESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLR 477
           +++ A    T   LC     P PSV + L     TV + ER F Y+          L +R
Sbjct: 429 QTYMAVQGSTAYLLCKAFGAPVPSVQW-LDEDGTTVLQDERFFPYA-------NGTLGIR 480

Query: 478 G-QAQAPPRVICTARN 492
             QA    R  C A N
Sbjct: 481 DLQANDTGRYFCLAAN 496



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 48/167 (28%), Positives = 82/167 (49%), Gaps = 13/167 (7%)

Query: 335 MVAVEGETVSILCSTQSNPDPILTIFKEKQILST--VIYESELQ-LELPAVSPEDDGEYW 391
           +VA++G+ + + C  +  P P +   +    +    V Y++  + L+L  V  EDDGEY 
Sbjct: 247 LVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYR 306

Query: 392 CVAENQYGQRATAFNLSVEFAPVLL--LESHCAAARDTVQCLCVVKSNPEPSVAFELPSR 449
           C+AEN  G    A+ ++VE AP  L   +SH     +T +  C V+  P+P V + +   
Sbjct: 307 CLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRI--N 364

Query: 450 NVTVNESEREFVYS-ERSGLVLTSILTLRGQAQAPPRVICTARNLYG 495
            + V E  ++  Y  +R  L+L+++     Q        C ARN +G
Sbjct: 365 GIPVEELAKDQKYRIQRGALILSNV-----QPSDTMVTQCEARNRHG 406



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 59/241 (24%), Positives = 95/241 (39%), Gaps = 27/241 (11%)

Query: 254 GSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL------LELEEVTPAEDGVYACLA 307
           G    L C     P P +TW  +G  + E   +         L L  V P++  V  C A
Sbjct: 342 GETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEA 401

Query: 308 ENAYGQDNRTVGLSVMYAPWKPTV--NGTMVAVEGETVSILCSTQSNPDPILTIFKEKQI 365
            N +G       + V+  P K     N T +AV+G T  +LC     P P +    E   
Sbjct: 402 RNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDG- 460

Query: 366 LSTVIYESEL------QLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFA------P 413
            +TV+ +          L +  +   D G Y+C+A N         NL V+ A      P
Sbjct: 461 -TTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGP 519

Query: 414 VLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNV-TVNESEREFVYSERSGLVLTS 472
              +E     +R T  C      + +PS+ +    R++  + +S++ F+  E   LV+ S
Sbjct: 520 RSTIEK--KGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFI--EDGRLVIHS 575

Query: 473 I 473
           +
Sbjct: 576 L 576



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 57/247 (23%), Positives = 88/247 (35%), Gaps = 37/247 (14%)

Query: 239 PPVIVEMNSS-VEAIEGSHVSLLCGADSNPPPLLTWMRDG-----------TVLREAVAE 286
           PPVI E +   +       +SL C A   P     W RDG           TV +   + 
Sbjct: 29  PPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSG 88

Query: 287 SLLLELEEVTPAE--DGVYACLAENAYGQD-NRTVGLSVMYAP-WKPTVNGTMVAVEGET 342
           S  +       A+   G+Y C A N  G   +  + L    AP W       +   EGE+
Sbjct: 89  SFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGES 148

Query: 343 VSILCSTQSNPDPILTIFKEKQIL-----STVIYESELQLELPAVSPEDD-GEYWC---- 392
           V + C+   + +P+   +   +IL       V       L    V   D+  +Y C    
Sbjct: 149 VVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHF 208

Query: 393 ------VAENQYGQRATAFNLSVEFAPVLLL----ESHCAAARDTVQCL-CVVKSNPEPS 441
                 + +     R  A N  ++  P LL      SH  A +     L C+ +  P P+
Sbjct: 209 PGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPT 268

Query: 442 VAFELPS 448
           + +  PS
Sbjct: 269 IKWLRPS 275


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.135    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,332,778
Number of Sequences: 37866
Number of extensions: 1258121
Number of successful extensions: 6313
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 202
Number of HSP's successfully gapped in prelim test: 190
Number of HSP's that attempted gapping in prelim test: 2970
Number of HSP's gapped (non-prelim): 1760
length of query: 626
length of database: 18,247,518
effective HSP length: 108
effective length of query: 518
effective length of database: 14,157,990
effective search space: 7333838820
effective search space used: 7333838820
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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