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Search of human proteins with 11225258
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|11225258 myelin associated glycoprotein isoform a precursor
[Homo sapiens]
(626 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|11225258 myelin associated glycoprotein isoform a precursor [... 1270 0.0
gi|18104957 myelin associated glycoprotein isoform b precursor [... 1167 0.0
gi|31377639 sialic acid binding Ig-like lectin 10 [Homo sapiens] 190 3e-48
gi|205830470 sialic acid binding Ig-like lectin 11 isoform 1 [Ho... 171 2e-42
gi|13489095 sialoadhesin precursor [Homo sapiens] 143 4e-34
gi|205830473 sialic acid binding Ig-like lectin 11 isoform 2 [Ho... 139 1e-32
gi|7657570 sialic acid binding Ig-like lectin 7 isoform 1 [Homo ... 128 1e-29
gi|94538343 sialic acid binding Ig-like lectin 8 [Homo sapiens] 127 4e-29
gi|4502659 sialic acid binding Ig-like lectin 5 [Homo sapiens] 121 2e-27
gi|23943856 sialic acid binding Ig-like lectin 9 [Homo sapiens] 119 8e-27
gi|16506826 sialic acid binding immunoglobulin-like lectin-like ... 118 1e-26
gi|16506828 sialic acid binding immunoglobulin-like lectin-like ... 118 1e-26
gi|193794821 sialic acid binding Ig-like lectin 6 isoform 1 prec... 115 9e-26
gi|157168355 CD22 molecule [Homo sapiens] 115 1e-25
gi|193794819 sialic acid binding Ig-like lectin 6 isoform 2 prec... 114 3e-25
gi|148762980 sialic acid binding Ig-like lectin 14 [Homo sapiens] 110 5e-24
gi|193794817 sialic acid binding Ig-like lectin 6 isoform 3 prec... 109 9e-24
gi|118572606 hemicentin 1 [Homo sapiens] 99 1e-20
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 96 1e-19
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 96 1e-19
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 96 1e-19
gi|130979981 CD33 antigen isoform 1 precursor [Homo sapiens] 94 5e-19
gi|109150416 peroxidasin [Homo sapiens] 90 5e-18
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 88 3e-17
gi|4507875 vascular cell adhesion molecule 1 isoform a precursor... 87 6e-17
gi|18201909 vascular cell adhesion molecule 1 isoform b precurso... 86 1e-16
gi|145275174 kin of IRRE-like 2 isoform c [Homo sapiens] 85 2e-16
gi|145275172 kin of IRRE-like 2 isoform b [Homo sapiens] 85 2e-16
gi|145275170 kin of IRRE-like 2 isoform a [Homo sapiens] 85 2e-16
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo... 84 5e-16
>gi|11225258 myelin associated glycoprotein isoform a precursor
[Homo sapiens]
Length = 626
Score = 1270 bits (3287), Expect = 0.0
Identities = 626/626 (100%), Positives = 626/626 (100%)
Query: 1 MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWY 60
MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWY
Sbjct: 1 MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWY 60
Query: 61 FNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGD 120
FNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGD
Sbjct: 61 FNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGD 120
Query: 121 LGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGL 180
LGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGL
Sbjct: 121 LGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGL 180
Query: 181 GEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP 240
GEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP
Sbjct: 181 GEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP 240
Query: 241 VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAED 300
VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAED
Sbjct: 241 VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAED 300
Query: 301 GVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIF 360
GVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIF
Sbjct: 301 GVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIF 360
Query: 361 KEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESH 420
KEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESH
Sbjct: 361 KEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESH 420
Query: 421 CAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQA 480
CAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQA
Sbjct: 421 CAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQA 480
Query: 481 QAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKK 540
QAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKK
Sbjct: 481 QAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKK 540
Query: 541 NVTESPSFSAGDNPPVLFSSDFRISGAPEKYESERRLGSERRLLGLRGEPPELDLSYSHS 600
NVTESPSFSAGDNPPVLFSSDFRISGAPEKYESERRLGSERRLLGLRGEPPELDLSYSHS
Sbjct: 541 NVTESPSFSAGDNPPVLFSSDFRISGAPEKYESERRLGSERRLLGLRGEPPELDLSYSHS 600
Query: 601 DLGKRPTKDSYTLTEELAEYAEIRVK 626
DLGKRPTKDSYTLTEELAEYAEIRVK
Sbjct: 601 DLGKRPTKDSYTLTEELAEYAEIRVK 626
>gi|18104957 myelin associated glycoprotein isoform b precursor
[Homo sapiens]
Length = 582
Score = 1167 bits (3019), Expect = 0.0
Identities = 573/574 (99%), Positives = 574/574 (100%)
Query: 1 MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWY 60
MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWY
Sbjct: 1 MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWY 60
Query: 61 FNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGD 120
FNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGD
Sbjct: 61 FNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGD 120
Query: 121 LGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGL 180
LGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGL
Sbjct: 121 LGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGL 180
Query: 181 GEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP 240
GEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP
Sbjct: 181 GEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP 240
Query: 241 VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAED 300
VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAED
Sbjct: 241 VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAED 300
Query: 301 GVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIF 360
GVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIF
Sbjct: 301 GVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIF 360
Query: 361 KEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESH 420
KEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESH
Sbjct: 361 KEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESH 420
Query: 421 CAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQA 480
CAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQA
Sbjct: 421 CAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQA 480
Query: 481 QAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKK 540
QAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKK
Sbjct: 481 QAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKK 540
Query: 541 NVTESPSFSAGDNPPVLFSSDFRISGAPEKYESE 574
NVTESPSFSAGDNPPVLFSSDFRISGAPEKYES+
Sbjct: 541 NVTESPSFSAGDNPPVLFSSDFRISGAPEKYESK 574
>gi|31377639 sialic acid binding Ig-like lectin 10 [Homo sapiens]
Length = 697
Score = 190 bits (483), Expect = 3e-48
Identities = 164/587 (27%), Positives = 256/587 (43%), Gaps = 63/587 (10%)
Query: 15 SASRGGHWGAWMPSSISAFEGTCVSIPCRFDFP--DELRPAVVHGVWYFNSPYPKNYPPV 72
S + G + + S+ EG C+S+PC F +P D +G W+ PV
Sbjct: 14 SQAMDGRFWIRVQESVMVPEGLCISVPCSFSYPRQDWTGSTPAYGYWFKAVTETTKGAPV 73
Query: 73 VFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYNQYTFSEH 132
+++ V S +GR +L GD NC+L++ + + +Y+FR + G Y +Y F
Sbjct: 74 ATNHQSREVEMSTRGRFQLTGDPAKGNCSLVIRDAQMQDESQYFFRVERGSYVRYNFMND 133
Query: 133 ----SVLDIVNTPNIVVPPEVVAGTEVEVSCMVP---DNCPELRPELSWLGHEGLGEPAV 185
V + P++ +P + G V V C+ + CP P SW G A
Sbjct: 134 GFFLKVTALTQKPDVYIPETLEPGQPVTVICVFNWAFEECPP--PSFSWTG-------AA 184
Query: 186 LGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEM 245
L + + T S+L F P + + L C F + + + V Y P + +
Sbjct: 185 LSS-QGTKPTTSHFSVLSFTPRPQDHNTDLTCHVDFSRKGVSAQRTVRLRVAYAPRDLVI 243
Query: 246 NSS-----------------VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA---VA 285
+ S +EA +G + LLC ADS PP L+W+ VL +
Sbjct: 244 SISRDNTPALEPQPQGNVPYLEAQKGQFLRLLCAADSQPPATLSWVLQNRVLSSSHPWGP 303
Query: 286 ESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTV-------------- 331
L LEL V + G Y C AEN G R + LSV Y P V
Sbjct: 304 RPLGLELPGVKAGDSGRYTCRAENRLGSQQRALDLSVQYPPENLRVMVSQANRTVLENLG 363
Query: 332 NGTMVAV-EGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEY 390
NGT + V EG+++ ++C T S+P L+ + Q+LS LELP V E +GE+
Sbjct: 364 NGTSLPVLEGQSLCLVCVTHSSPPARLSWTQRGQVLSPSQPSDPGVLELPRVQVEHEGEF 423
Query: 391 WCVAENQYGQRATAFNLSVEFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRN 450
C A + G + + +LSV ++P LL S C+ + + C C +++P PS+ + L
Sbjct: 424 TCHARHPLGSQHVSLSLSVHYSPKLLGPS-CSWEAEGLHCSCSSQASPAPSLRWWLGEEL 482
Query: 451 VTVNESEREF-VYSERSGLVLTSILTLRGQAQAPPRVICTARNLYGAKS---LELP-FQG 505
+ N S+ F V +G S L+L G + R+ C A N++GA+S L+LP +G
Sbjct: 483 LEGNSSQDSFEVTPSSAGPWANSSLSLHGGLSSGLRLRCEAWNVHGAQSGSILQLPDKKG 542
Query: 506 AHRLMWAKIGPVG---AVVAFAILIAIVCYITQTRRKKNVTESPSFS 549
++ +G + F L I+ I RR + T P FS
Sbjct: 543 LISTAFSNGAFLGIGITALLFLCLALIIMKILPKRRTQTETPRPRFS 589
>gi|205830470 sialic acid binding Ig-like lectin 11 isoform 1 [Homo
sapiens]
Length = 698
Score = 171 bits (432), Expect = 2e-42
Identities = 143/510 (28%), Positives = 226/510 (44%), Gaps = 58/510 (11%)
Query: 34 EGTCVSIPCRFDFP----DELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRS 89
EG CV + C +P DE A +G W+ PK PV ++++ V S + R
Sbjct: 46 EGLCVIVSCNLSYPRDGWDESTAA--YGYWFKGRTSPKTGAPVATNNQSREVEMSTRDRF 103
Query: 90 RLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYNQYTFSEHS----VLDIVNTPNIVV 145
+L GD G +C+L++ + E Y+FR + G +++F ++ V + P++ +
Sbjct: 104 QLTGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTALTKKPDVYI 163
Query: 146 PPEVVAGTEVEVSCMVP---DNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLL 202
P + G V V C+ CP P SW G A L R T S+L
Sbjct: 164 PETLEPGQPVTVICVFNWAFKKCP--APSFSWTG-------AALSPRRTRPST-SHFSVL 213
Query: 203 HFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP---VIVEMNSSVEAIE------ 253
F P+ + + L C F + + + V Y P +I + + A+E
Sbjct: 214 SFTPSPQDHDTDLTCHVDFSRKGVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVI 273
Query: 254 ------GSHVSLLCGADSNPPPLLTWMRDGTVLREA---VAESLLLELEEVTPAEDGVYA 304
G + LLC ADS PP L+W+ VL + +L LEL V + G Y
Sbjct: 274 YLEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYT 333
Query: 305 CLAENAYGQDNRTVGLSVMYAPWKPTV--------------NGTMVAV-EGETVSILCST 349
C AEN G + + LSV Y P V NGT + V EG+++ ++C T
Sbjct: 334 CRAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVT 393
Query: 350 QSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSV 409
S+P L+ + Q + LELP + E +GE+ C A++ G + + +LSV
Sbjct: 394 HSSPPARLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQHPLGSQHVSLSLSV 453
Query: 410 EFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREF-VYSERSGL 468
+ P LL S C+ + + C C +++P PS+ + L + N S+ F V +G
Sbjct: 454 HYPPQLLGPS-CSWEAEGLHCSCSSQASPAPSLRWWLGEELLEGNSSQGSFEVTPSSAGP 512
Query: 469 VLTSILTLRGQAQAPPRVICTARNLYGAKS 498
S L+L G + R+ C A N++GA+S
Sbjct: 513 WANSSLSLHGGLSSGLRLRCKAWNVHGAQS 542
>gi|13489095 sialoadhesin precursor [Homo sapiens]
Length = 1709
Score = 143 bits (361), Expect = 4e-34
Identities = 111/422 (26%), Positives = 200/422 (47%), Gaps = 26/422 (6%)
Query: 7 LPLFWIMISASRGGH--WGAWMPSSISAFEGTCVSIPCRFDFPDELR-PAVVHGVWYFNS 63
LP ++ S G WG P + +G+C+ IPC F FP ++ P + +WY++
Sbjct: 4 LPKLLLLASFFPAGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYD- 62
Query: 64 PYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGG 123
Y V + ++V F+GR+ +G+ R C LLL ++ PE G Y FR ++
Sbjct: 63 -YSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISE 121
Query: 124 YNQYTFSEHSVLDIV---NTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGL 180
N+++ + +++ + P I P E++ GTEV+ +C P C + + L W G +
Sbjct: 122 VNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPA 181
Query: 181 GEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP 240
+ E G + LH + + +G L CQ S N Q E + VKY P
Sbjct: 182 RSVTFNSQKFEPTGVG-HLETLHMAMSWQDHGRILRCQLSVANHRAQSE--IHLQVKYAP 238
Query: 241 VIVEM---NSSVEAIEGSHVSLLCGADSNPPPL--LTWMRDGTVLREAVAESLLLELEEV 295
V++ S + G V+L C +S+ P + + W++DG L+ ++ +L L +
Sbjct: 239 KGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQ---TKTGVLHLPQA 295
Query: 296 TPAEDGVYACLAENAYGQ-DNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSN-P 353
++ GVY C AEN G + + L + A + + G + +E +TV+++C+T + P
Sbjct: 296 AWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPI--LENQTVTLVCNTPNEAP 353
Query: 354 DPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYG-QRATAFNLSVEFA 412
+ + + +L + L+L L + D G Y+C +N +G +R+ ++ V
Sbjct: 354 SDLRYSWYKNHVLLEDAHSHTLRLHL--ATRADTGFYFCEVQNVHGSERSGPVSVVVNHP 411
Query: 413 PV 414
P+
Sbjct: 412 PL 413
Score = 61.6 bits (148), Expect = 2e-09
Identities = 51/218 (23%), Positives = 89/218 (40%), Gaps = 18/218 (8%)
Query: 243 VEMNSSVEAIEGSHVSLLCGADSNPPPLL--TWMRDGTVLREAVAESLLLELEEVTPAED 300
V+++ + +E V+L+C + P L +W ++ +L +A + +L L L T A+
Sbjct: 328 VQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHL--ATRADT 385
Query: 301 GVYACLAENAYGQDNR-TVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTI 359
G Y C +N +G + V + V + P P + + G + CS S P L +
Sbjct: 386 GFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVL 445
Query: 360 FKEKQILSTVIYESE-------------LQLELPAVSPEDDGEYWCVAENQYGQRATAFN 406
IL++ +S+ L+LE+ + D GEY C A N G + +
Sbjct: 446 SHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLD 505
Query: 407 LSVEFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVAF 444
A +L+ + V C +P P F
Sbjct: 506 FHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARF 543
Score = 59.7 bits (143), Expect = 8e-09
Identities = 64/237 (27%), Positives = 99/237 (41%), Gaps = 34/237 (14%)
Query: 187 GRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMN 246
G + EDEG ++ C+AS NT Q A D + V V
Sbjct: 1056 GAMLEDEGVYI-------------------CEAS--NTLGQASASADFDAQAVNVQVWPG 1094
Query: 247 SSVEAIEGSHVSLLCGADSNPPPLLT--WMRDGTVLREAVAESLLLELEEVTPAEDGVYA 304
++V EG V+L C + P LT W +DG +A + + L VT + Y
Sbjct: 1095 ATVR--EGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHS----IPLPNVTVRDATSYR 1148
Query: 305 CLA--ENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKE 362
C + +R + L V+YAP + + + G+ +LC+ S P L +
Sbjct: 1149 CGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHA 1208
Query: 363 KQILSTVIYES---ELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL 416
++L++ S L+LEL P D+G Y C A + GQ T+ L +E V+L
Sbjct: 1209 GRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVIL 1265
Score = 59.3 bits (142), Expect = 1e-08
Identities = 95/388 (24%), Positives = 150/388 (38%), Gaps = 59/388 (15%)
Query: 194 GTWVQ---VSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVE 250
G W+Q + L F+ A+ CQA T A++ V Y P ++S +
Sbjct: 1298 GRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRP-AALQVLYAPQDAVLSSFRD 1356
Query: 251 AIEGSHVSLLCGADSNPPPLLTWMRDGTVLR---------------EAVAESLLLELEEV 295
+ S + C DS PP L DG VL + +L L++++V
Sbjct: 1357 SRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV 1416
Query: 296 TPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDP 355
PA D Y C A+N G + L V A + + EG +++ C P P
Sbjct: 1417 -PAGDDTYVCTAQNLLGSISTIGRLQVEGA--RVVAEPGLDVPEGAALNLSCRLLGGPGP 1473
Query: 356 I-----LTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATA-FNLSV 409
+ + ++++ + E L V+ G Y C+AE G A+A L V
Sbjct: 1474 VGNSTFAWFWNDRRLHA----EPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRV 1529
Query: 410 EFAP----VLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSER 465
+ P +++ R + C V S P S+ L SR V S+ + +E
Sbjct: 1530 LYPPKTPTMMVFVEPEGGLRGILDCR--VDSEPLASLTLHLGSR--LVASSQPQGAPAEP 1585
Query: 466 SGLVLTSILTLRGQAQA-----PPRVICTARNLYGAKSLELPF--QGAHR------LMWA 512
VL S LR +A IC+A N+ G+ S F + HR L+W
Sbjct: 1586 HIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVRALHRLHQFQQLLWV 1645
Query: 513 KIGPVGAVVAFAILIAIV--CYITQTRR 538
+G +V +L+ + CY + RR
Sbjct: 1646 ----LGLLVGLLLLLLGLGACYTWRRRR 1669
Score = 58.9 bits (141), Expect = 1e-08
Identities = 58/249 (23%), Positives = 98/249 (39%), Gaps = 22/249 (8%)
Query: 253 EGSHVSLLCGAD---SNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDGVYAC-LAE 308
EG+ +L C + P +W R+G + + E++ L V + +YAC +
Sbjct: 721 EGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETVTLL--PVARTDAALYACRILT 778
Query: 309 NAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILST 368
A Q + V LSV+Y P +P ++ + +G +C+ S P +L +F + +L+T
Sbjct: 779 EAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLAT 838
Query: 369 VI--------------YESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPV 414
+ + L+LE+ + D G Y C A N G T+ V A V
Sbjct: 839 SLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWV 898
Query: 415 LLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSIL 474
+ S V C V + ++ + ES + + + LT
Sbjct: 899 QVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATL--RFAAITLTQAG 956
Query: 475 TLRGQAQAP 483
QAQAP
Sbjct: 957 AYHCQAQAP 965
Score = 57.4 bits (137), Expect = 4e-08
Identities = 58/249 (23%), Positives = 95/249 (38%), Gaps = 37/249 (14%)
Query: 243 VEMNSSVEAIEGSHVSLLCGADSNPPPLLT--WMRDGTVLREAVAESLLLELEEVTPAED 300
V+++ S E EG V L C + P + W RDG L+E+ S L +T +
Sbjct: 898 VQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST--SATLRFAAITLTQA 955
Query: 301 GVYACLAE---NAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPIL 357
G Y C A+ +A + L V YAP T+ M G +LC S+P L
Sbjct: 956 GAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQL 1015
Query: 358 TIFKEKQILSTVIY-----------------ESELQLELPAVSPEDDGEYWCVAENQYGQ 400
+ +++++ + + L+LE+ ED+G Y C A N GQ
Sbjct: 1016 RLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQ 1075
Query: 401 RATAFNLSVEFAPVLLLESHCAAARDTVQCLCVV-------------KSNPEPSVAFELP 447
+ + + + V + V C+V + + A +P
Sbjct: 1076 ASASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSIP 1135
Query: 448 SRNVTVNES 456
NVTV ++
Sbjct: 1136 LPNVTVRDA 1144
Score = 55.1 bits (131), Expect = 2e-07
Identities = 52/228 (22%), Positives = 89/228 (39%), Gaps = 31/228 (13%)
Query: 245 MNSSVEAIEGSHVSLLCGADSNPPP--LLTWMRDGTVLREAVAESLLLELEEVTPAEDGV 302
++ + E +EG V+L C + +P P +W +G +L E SLLL T A G
Sbjct: 515 ISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSSLLLPAASSTDA--GS 572
Query: 303 YACLAENAYGQDNRT--VGLSVMYAPWKPTVNGTMV-----AVEGETVSILCSTQSNPDP 355
Y C A + + + L+V+Y P +PT + A G +LC S+P
Sbjct: 573 YHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPA 632
Query: 356 ILTIFKEKQILSTVIYESE--------------------LQLELPAVSPEDDGEYWCVAE 395
L + + ++++T + L++E+ E++G Y C A
Sbjct: 633 RLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEAS 692
Query: 396 NQYGQRATAFNLSVEFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVA 443
N G +T+ + + + + SH C V S A
Sbjct: 693 NALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPA 740
Score = 54.3 bits (129), Expect = 3e-07
Identities = 95/398 (23%), Positives = 144/398 (36%), Gaps = 70/398 (17%)
Query: 147 PEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVP 206
PE+ G V +SC V PE W + + LR T Q H
Sbjct: 904 PELQEGQAVVLSCQVHTGVPE-GTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYH--- 959
Query: 207 TREANGHRLGCQASFPNT-TLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADS 265
CQA P + T S+ V Y P V + + ++ G LLC DS
Sbjct: 960 ----------CQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDS 1009
Query: 266 NPPPLLTWMR---------------DGTVLREAVA---ESLLLELEEVTPAEDGVYACLA 307
+PP L + +G+ R VA +L LE+ ++GVY C A
Sbjct: 1010 DPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEA 1069
Query: 308 ENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILS 367
N GQ + + + T+ EG+ V++ C ++ Q+
Sbjct: 1070 SNTLGQASASADFDAQAVNVQVWPGATV--REGQLVNLTC--------LVWTTHPAQLTY 1119
Query: 368 TVIYESELQLE-----LPAVSPEDDGEYWCVA--ENQYGQRATAFNLSVEFAP-----VL 415
T + + +L+ LP V+ D Y C + + + L V +AP
Sbjct: 1120 TWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTY 1179
Query: 416 LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILT 475
LLESH LC V S P +A ++ + R S + + T L
Sbjct: 1180 LLESH---GGQLALVLCTVDSRPPAQLA---------LSHAGRLLASSTAASVPNTLRLE 1227
Query: 476 LRG-QAQAPPRVICTARNLYGA--KSLELPFQGAHRLM 510
LRG Q + C+AR+ G SLEL +G ++
Sbjct: 1228 LRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVIL 1265
Score = 47.8 bits (112), Expect = 3e-05
Identities = 44/182 (24%), Positives = 71/182 (39%), Gaps = 19/182 (10%)
Query: 230 GYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAE--- 286
G S+ V +PP+ + + +E G L C S P L G +L +
Sbjct: 402 GPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDH 461
Query: 287 -----------SLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTM 335
SL LE+ ++ + G Y C A N+ G T+ A + ++
Sbjct: 462 SPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAA--RLLISPAA 519
Query: 336 VAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESE-LQLELPAVSPEDDGEYWCVA 394
VEG+ V++ C + +P P + +++E L LPA S D G Y C A
Sbjct: 520 EVVEGQAVTLSCRSGLSPTPDARF--SWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRA 577
Query: 395 EN 396
+
Sbjct: 578 RD 579
Score = 45.8 bits (107), Expect = 1e-04
Identities = 63/282 (22%), Positives = 100/282 (35%), Gaps = 39/282 (13%)
Query: 152 GTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSL--LHFVPTRE 209
GTE ++C V E G PA R W Q L + +P
Sbjct: 722 GTEANLTCNV--------------SREAAGSPANFSWFRNGV-LWAQGPLETVTLLPVAR 766
Query: 210 ANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPP 269
+ C+ Q + V YPP ++++ ++ +G +C DS P
Sbjct: 767 TDAALYACRI-LTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLA 825
Query: 270 LLTWMR---------------DGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQD 314
LL G +A A SL LE+ E+ + G Y C A N G
Sbjct: 826 LLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSS 885
Query: 315 NRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESE 374
N ++ V A W V+ + EG+ V + C + P T ++ + + +
Sbjct: 886 NTSLFFQVRGA-W-VQVSPSPELQEGQAVVLSCQVHTGV-PEGTSYRWYRDGQPLQESTS 942
Query: 375 LQLELPAVSPEDDGEYWCVAE---NQYGQRATAFNLSVEFAP 413
L A++ G Y C A+ + A +L V +AP
Sbjct: 943 ATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAP 984
>gi|205830473 sialic acid binding Ig-like lectin 11 isoform 2 [Homo
sapiens]
Length = 602
Score = 139 bits (349), Expect = 1e-32
Identities = 116/422 (27%), Positives = 182/422 (43%), Gaps = 56/422 (13%)
Query: 34 EGTCVSIPCRFDFP----DELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRS 89
EG CV + C +P DE A +G W+ PK PV ++++ V S + R
Sbjct: 46 EGLCVIVSCNLSYPRDGWDESTAA--YGYWFKGRTSPKTGAPVATNNQSREVEMSTRDRF 103
Query: 90 RLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYNQYTFSEHS----VLDIVNTPNIVV 145
+L GD G +C+L++ + E Y+FR + G +++F ++ V + P++ +
Sbjct: 104 QLTGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTALTKKPDVYI 163
Query: 146 PPEVVAGTEVEVSCMVP---DNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLL 202
P + G V V C+ CP P SW G A L R T S+L
Sbjct: 164 PETLEPGQPVTVICVFNWAFKKCP--APSFSWTG-------AALSPRRTRPST-SHFSVL 213
Query: 203 HFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP---VIVEMNSSVEAIE------ 253
F P+ + + L C F + + + V Y P +I + + A+E
Sbjct: 214 SFTPSPQDHDTDLTCHVDFSRKGVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVI 273
Query: 254 ------GSHVSLLCGADSNPPPLLTWMRDGTVLREA---VAESLLLELEEVTPAEDGVYA 304
G + LLC ADS PP L+W+ VL + +L LEL V + G Y
Sbjct: 274 YLEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYT 333
Query: 305 CLAENAYGQDNRTVGLSVMYAPWKPTV--------------NGTMVAV-EGETVSILCST 349
C AEN G + + LSV Y P V NGT + V EG+++ ++C T
Sbjct: 334 CRAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVT 393
Query: 350 QSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSV 409
S+P L+ + Q + LELP + E +GE+ C A++ G + + +LSV
Sbjct: 394 HSSPPARLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQHPLGSQHVSLSLSV 453
Query: 410 EF 411
+
Sbjct: 454 HW 455
Score = 47.8 bits (112), Expect = 3e-05
Identities = 36/115 (31%), Positives = 55/115 (47%), Gaps = 17/115 (14%)
Query: 316 RTVGLSVMYAPWKPTVN------------GTMVAVE---GETVSILCSTQSNPDPILTIF 360
RTV L V YAP ++ G ++ +E G+ + +LC+ S P L+
Sbjct: 241 RTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFLRLLCAADSQPPATLSWV 300
Query: 361 KEKQILSTVIY--ESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAP 413
+ ++LS+ L LEL V D G Y C AEN+ G + A +LSV++ P
Sbjct: 301 LQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTCRAENRLGSQQQALDLSVQYPP 355
>gi|7657570 sialic acid binding Ig-like lectin 7 isoform 1 [Homo
sapiens]
Length = 467
Score = 128 bits (322), Expect = 1e-29
Identities = 98/368 (26%), Positives = 163/368 (44%), Gaps = 39/368 (10%)
Query: 1 MIFLTALPLFW----IMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFP--DELRPAV 54
M+ L LPL W + S + M SS++ EG CV + C F +P +
Sbjct: 1 MLLLLLLPLLWGRERVEGQKSNRKDYSLTMQSSVTVQEGMCVHVRCSFSYPVDSQTDSDP 60
Query: 55 VHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGK 114
VHG W+ PV + V E + R LLGD +NCTL + + G+
Sbjct: 61 VHGYWFRAGNDISWKAPVATNNPAWAVQEETRDRFHLLGDPQTKNCTLSIRDARMSDAGR 120
Query: 115 YYFRGDLGGYN-QYTFSEHSV--LDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPE-LRP 170
Y+FR + G Y + + SV + + PNI++P + +G ++C VP C + P
Sbjct: 121 YFFRMEKGNIKWNYKYDQLSVNVTALTHRPNILIPGTLESGCFQNLTCSVPWACEQGTPP 180
Query: 171 ELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEG 230
+SW+G + + + S+L +P + +G L CQ + P +
Sbjct: 181 MISWMGTS----------VSPLHPSTTRSSVLTLIPQPQHHGTSLTCQVTLPGAGVTTNR 230
Query: 231 YASMDVKYPPVIVEM---------------NSSVEAIEGSHVSLLCGADSNPPPLLTW-M 274
++V YPP + + +SS+ +EG + L+C DSNPP L+W
Sbjct: 231 TIQLNVSYPPQNLTVTVFQGEGTASTALGNSSSLSVLEGQSLRLVCAVDSNPPARLSWTW 290
Query: 275 RDGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVM--YAPWKPTVN 332
R T+ + L+LEL +V ++G + C A+N+ G + ++ LS+ Y V+
Sbjct: 291 RSLTLYPSQPSNPLVLEL-QVHLGDEGEFTCRAQNSLGSQHVSLNLSLQQEYTGKMRPVS 349
Query: 333 GTMVAVEG 340
G ++ G
Sbjct: 350 GVLLGAVG 357
Score = 47.8 bits (112), Expect = 3e-05
Identities = 42/165 (25%), Positives = 70/165 (42%), Gaps = 19/165 (11%)
Query: 264 DSNPPPLLTWMRDG-TVLREAVAESLLLELEEVTPAEDGVYACLAE--NAYGQDNRTVGL 320
+ PP+++WM + L + S +L L C A NRT+ L
Sbjct: 175 EQGTPPMISWMGTSVSPLHPSTTRSSVLTLIPQPQHHGTSLTCQVTLPGAGVTTNRTIQL 234
Query: 321 SVMYAPWKPTV---------------NGTMVAVEGETVSILCSTQSNPDPILTIFKEKQI 365
+V Y P TV + ++ +EG+++ ++C+ SNP L+
Sbjct: 235 NVSYPPQNLTVTVFQGEGTASTALGNSSSLSVLEGQSLRLVCAVDSNPPARLSWTWRSLT 294
Query: 366 LSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVE 410
L + L LEL V D+GE+ C A+N G + + NLS++
Sbjct: 295 LYPSQPSNPLVLELQ-VHLGDEGEFTCRAQNSLGSQHVSLNLSLQ 338
>gi|94538343 sialic acid binding Ig-like lectin 8 [Homo sapiens]
Length = 499
Score = 127 bits (318), Expect = 4e-29
Identities = 99/381 (25%), Positives = 160/381 (41%), Gaps = 45/381 (11%)
Query: 1 MIFLTALPLFWIMISASRGGHWG----AWMPSSISAFEGTCVSIPCRFDFPDE--LRPAV 54
++ L LPL W +G + ++ EG CV +PC F +P +
Sbjct: 2 LLLLLLLPLLWGTKGMEGDRQYGDGYLLQVQELVTVQEGLCVHVPCSFSYPQDGWTDSDP 61
Query: 55 VHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGK 114
VHG W+ P PV + + V QGR +LLGD+ +C+L + + G
Sbjct: 62 VHGYWFRAGDRPYQDAPVATNNPDREVQAETQGRFQLLGDIWSNDCSLSIRDARKRDKGS 121
Query: 115 YYFRGDLGGYN-------QYTFSEHSVL--DIVNTPNIVVPPEVVAGTEVEVSCMVPDNC 165
Y+FR + G Y + SV + + P+I++ + +G ++C VP C
Sbjct: 122 YFFRLERGSMKWSYKSQLNYKTKQLSVFVTALTHRPDILILGTLESGHSRNLTCSVPWAC 181
Query: 166 PE-LRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNT 224
+ P +SW+G + T + S+L P + +G L CQ + P T
Sbjct: 182 KQGTPPMISWIG----------ASVSSPGPTTARSSVLTLTPKPQDHGTSLTCQVTLPGT 231
Query: 225 TLQFEGYASMDVKYPPVIVEM---------------NSSVEAIEGSHVSLLCGADSNPPP 269
+ +DV YPP + M SS+ +EG + L+C +SNPP
Sbjct: 232 GVTTTSTVRLDVSYPPWNLTMTVFQGDATASTALGNGSSLSVLEGQSLRLVCAVNSNPPA 291
Query: 270 LLTWMRDG-TVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVM---YA 325
L+W R T+ + LLEL V ++G + C A+NA G + ++ LS+
Sbjct: 292 RLSWTRGSLTLCPSRSSNPGLLELPRVHVRDEGEFTCRAQNAQGSQHISLSLSLQNEGTG 351
Query: 326 PWKPTVNGTMVAVEGETVSIL 346
+P T+ AV G + L
Sbjct: 352 TSRPVSQVTLAAVGGAGATAL 372
Score = 50.8 bits (120), Expect = 4e-06
Identities = 33/109 (30%), Positives = 54/109 (49%), Gaps = 15/109 (13%)
Query: 317 TVGLSVMYAPWKPTV--------------NGTMVAV-EGETVSILCSTQSNPDPILTIFK 361
TV L V Y PW T+ NG+ ++V EG+++ ++C+ SNP L+ +
Sbjct: 238 TVRLDVSYPPWNLTMTVFQGDATASTALGNGSSLSVLEGQSLRLVCAVNSNPPARLSWTR 297
Query: 362 EKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVE 410
L + LELP V D+GE+ C A+N G + + +LS++
Sbjct: 298 GSLTLCPSRSSNPGLLELPRVHVRDEGEFTCRAQNAQGSQHISLSLSLQ 346
>gi|4502659 sialic acid binding Ig-like lectin 5 [Homo sapiens]
Length = 551
Score = 121 bits (303), Expect = 2e-27
Identities = 111/435 (25%), Positives = 181/435 (41%), Gaps = 48/435 (11%)
Query: 1 MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFP--DELRPAVVHGV 58
M+ L LPL W S + + S++ EG CV +PC F +P ++
Sbjct: 1 MLPLLLLPLLWGG-SLQEKPVYELQVQKSVTVQEGLCVLVPCSFSYPWRSWYSSPPLYVY 59
Query: 59 WYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFR 118
W+ + P V + + V QGR RLLGD+ +NC+L + + E G Y+FR
Sbjct: 60 WFRDGEIPYYAEVVATNNPDRRVKPETQGRFRLLGDVQKKNCSLSIGDARMEDTGSYFFR 119
Query: 119 GDLGGYNQYTFSEH----SVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPEL-- 172
+ G +Y++ ++ V ++ P+I + +G +SC +P +C E P L
Sbjct: 120 VERGRDVKYSYQQNKLNLEVTALIEKPDIHFLEPLESGRPTRLSCSLPGSC-EAGPPLTF 178
Query: 173 SWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYA 232
SW G+ L + + S L P E +G L CQ + E
Sbjct: 179 SWTGN----------ALSPLDPETTRSSELTLTPRPEDHGTNLTCQMKRQGAQVTTERTV 228
Query: 233 SMDVKYPP------------VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVL 280
++V Y P I++ S + +EG + LLC A SNPP L+W + L
Sbjct: 229 QLNVSYAPQTITIFRNGIALEILQNTSYLPVLEGQALRLLCDAPSNPPAHLSWFQGSPAL 288
Query: 281 REA-VAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVE 339
++ + +LEL V AE+G + C A++ G + LSV P + G + E
Sbjct: 289 NATPISNTGILELRRVRSAEEGGFTCRAQHPLGFLQIFLNLSVYSL---PQLLGPSCSWE 345
Query: 340 GETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSP------------EDD 387
E + CS ++ P P L E++ L + ++ + P D
Sbjct: 346 AEGLHCRCSFRARPAPSLCWRLEEKPLEGNSSQGSFKVNSSSAGPWANSSLILHGGLSSD 405
Query: 388 GEYWCVAENQYGQRA 402
+ C A N YG ++
Sbjct: 406 LKVSCKAWNIYGSQS 420
Score = 89.7 bits (221), Expect = 7e-18
Identities = 101/392 (25%), Positives = 161/392 (41%), Gaps = 33/392 (8%)
Query: 258 SLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDGVYACLA-----ENAYG 312
SL ++ PP +W G L E+ +TP + L + A
Sbjct: 165 SLPGSCEAGPPLTFSWT--GNALSPLDPETTRSSELTLTPRPEDHGTNLTCQMKRQGAQV 222
Query: 313 QDNRTVGLSVMYAPWKPTV--NGTMVAV----------EGETVSILCSTQSNPDPILTIF 360
RTV L+V YAP T+ NG + + EG+ + +LC SNP L+ F
Sbjct: 223 TTERTVQLNVSYAPQTITIFRNGIALEILQNTSYLPVLEGQALRLLCDAPSNPPAHLSWF 282
Query: 361 KEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESH 420
+ L+ + LEL V ++G + C A++ G NLSV P LL S
Sbjct: 283 QGSPALNATPISNTGILELRRVRSAEEGGFTCRAQHPLGFLQIFLNLSVYSLPQLLGPS- 341
Query: 421 CAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREF-VYSERSGLVLTSILTLRGQ 479
C+ + + C C ++ P PS+ + L + + N S+ F V S +G S L L G
Sbjct: 342 CSWEAEGLHCRCSFRARPAPSLCWRLEEKPLEGNSSQGSFKVNSSSAGPWANSSLILHGG 401
Query: 480 AQAPPRVICTARNLYGAKS-LELPFQGAHRL----MWAKIGPVGAVVAFAILIAIVCYIT 534
+ +V C A N+YG++S L QG L + A +G G + I + ++ ++
Sbjct: 402 LSSDLKVSCKAWNIYGSQSGSVLLLQGRSNLGTGVVPAALGGAGVMALLCICLCLIFFLI 461
Query: 535 QTRRKKNVTESPSFSAGDNPPVL--FSSDFRISGAPEKYESERRLGSERRLLGLRGEPPE 592
R+K P D P++ +S R P+ + + L + E
Sbjct: 462 VKARRKQAAGRPE-KMDDEDPIMGTITSGSRKKPWPDSPGDQASPPGDAPPLEEQKELHY 520
Query: 593 LDLSYSHSDLGKRPTKDSYTLTEELAEYAEIR 624
LS+ S++ R KD EY+EI+
Sbjct: 521 ASLSF--SEMKSREPKDQE--APSTTEYSEIK 548
>gi|23943856 sialic acid binding Ig-like lectin 9 [Homo sapiens]
Length = 463
Score = 119 bits (298), Expect = 8e-27
Identities = 98/375 (26%), Positives = 159/375 (42%), Gaps = 41/375 (10%)
Query: 2 IFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDE--LRPA-VVHGV 58
+ L LPL W A M SS++ EG CV +PC F +P + P VVHG
Sbjct: 1 MLLLLLPLLWGRERAEGQTSKLLTMQSSVTVQEGLCVHVPCSFSYPSHGWIYPGPVVHGY 60
Query: 59 WYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFR 118
W+ PV + + V E + R LLGD +NCTL + + G+Y+FR
Sbjct: 61 WFREGANTDQDAPVATNNPARAVWEETRDRFHLLGDPHTKNCTLSIRDARRSDAGRYFFR 120
Query: 119 GDLGGYNQYTFSEH----SVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPE-LRPELS 173
+ G ++ + H +V + + PNI++P + +G ++C VP C + P +S
Sbjct: 121 MEKGSI-KWNYKHHRLSVNVTALTHRPNILIPGTLESGCPQNLTCSVPWACEQGTPPMIS 179
Query: 174 WLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYAS 233
W+G + + + + S+L +P + +G L CQ +FP ++
Sbjct: 180 WIGTS----------VSPLDPSTTRSSVLTLIPQPQDHGTSLTCQVTFPGASVTTNKTVH 229
Query: 234 MDVKYPP---------------VIVEMNSSVEAIEGSHVSLLC---GADSNPPP--LLTW 273
++V YPP ++ SS+ EG + L+C DSNPP L+W
Sbjct: 230 LNVSYPPQNLTMTVFQGDGTVSTVLGNGSSLSLPEGQSLRLVCAVDAVDSNPPARLSLSW 289
Query: 274 MRDGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNG 333
R T+ + +LEL V + + C A+N G + +S+ G
Sbjct: 290 -RGLTLCPSQPSNPGVLELPWVHLRDAAEFTCRAQNPLGSQQVYLNVSLQSKATSGVTQG 348
Query: 334 TMVAVEGETVSILCS 348
+V G T + S
Sbjct: 349 -VVGGAGATALVFLS 362
Score = 38.5 bits (88), Expect = 0.019
Identities = 40/168 (23%), Positives = 70/168 (41%), Gaps = 21/168 (12%)
Query: 264 DSNPPPLLTWMRDG-TVLREAVAESLLLELEEVTPAEDGVYACLAE--NAYGQDNRTVGL 320
+ PP+++W+ + L + S +L L C A N+TV L
Sbjct: 171 EQGTPPMISWIGTSVSPLDPSTTRSSVLTLIPQPQDHGTSLTCQVTFPGASVTTNKTVHL 230
Query: 321 SVMYAPWKPTV--------------NGTMVAV-EGETVSILCSTQ---SNPDPILTIFKE 362
+V Y P T+ NG+ +++ EG+++ ++C+ SNP L++
Sbjct: 231 NVSYPPQNLTMTVFQGDGTVSTVLGNGSSLSLPEGQSLRLVCAVDAVDSNPPARLSLSWR 290
Query: 363 KQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVE 410
L + LELP V D E+ C A+N G + N+S++
Sbjct: 291 GLTLCPSQPSNPGVLELPWVHLRDAAEFTCRAQNPLGSQQVYLNVSLQ 338
>gi|16506826 sialic acid binding immunoglobulin-like lectin-like
protein 1 isoform b precursor [Homo sapiens]
Length = 477
Score = 118 bits (296), Expect = 1e-26
Identities = 95/385 (24%), Positives = 162/385 (42%), Gaps = 41/385 (10%)
Query: 26 MPSSISAFEGTCVSIPCRFDFP--DELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHE 83
+P S++ EG CVS+PC +P + + V+G W+ PV + + V E
Sbjct: 37 VPESVTVQEGLCVSVPCSVLYPHYNWTASSPVYGSWFKEGADIPWDIPVATNTPSGKVQE 96
Query: 84 SFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYN-QYTFSEHS--VLDIVNT 140
GR LLGD NC+L + + GKYYF+ + G Y + + S V + +
Sbjct: 97 DTHGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVERGSRKWNYIYDKLSVHVTALTHM 156
Query: 141 PNIVVPPEVVAGTEVEVSCMVPDNCPE-LRPELSWLGHEGLGEPAVLGRLREDEGTWVQV 199
P +P + +G ++C VP C + P ++W+G + + T +
Sbjct: 157 PTFSIPGTLESGHPRNLTCSVPWACEQGTPPTITWMG----------ASVSSLDPTITRS 206
Query: 200 SLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEM-------------- 245
S+L +P + +G L CQ + P + +++ YPP + M
Sbjct: 207 SMLSLIPQPQDHGTSLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLR 266
Query: 246 -NSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESL-LLELEEVTPAEDGVY 303
S++ +EG + L+C DSNPP L+W L + + +L +LEL V ++G +
Sbjct: 267 NGSALSVLEGQSLHLVCAVDSNPPARLSWTWGSLTLSPSQSSNLGVLELPRVHVKDEGEF 326
Query: 304 ACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEK 363
C A+N G + ++ LS+ + G M + G T+ +F
Sbjct: 327 TCRAQNPLGSQHISLSLSL-----QNEYTGKMRPISGVTLGAF----GGAGATALVFLYF 377
Query: 364 QILSTVIYESELQLELPAVSPEDDG 388
I+ V+ + PAV D G
Sbjct: 378 CIIFVVVRSCRKKSARPAVGVGDTG 402
Score = 49.3 bits (116), Expect = 1e-05
Identities = 44/166 (26%), Positives = 73/166 (43%), Gaps = 20/166 (12%)
Query: 264 DSNPPPLLTWMRDG-TVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQD---NRTVG 319
+ PP +TWM + L + S +L L P + G G R V
Sbjct: 182 EQGTPPTITWMGASVSSLDPTITRSSMLSLIP-QPQDHGTSLTCQVTLPGAGVTMTRAVR 240
Query: 320 LSVMYAPWKPTV--------------NGTMVAV-EGETVSILCSTQSNPDPILTIFKEKQ 364
L++ Y P T+ NG+ ++V EG+++ ++C+ SNP L+
Sbjct: 241 LNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVCAVDSNPPARLSWTWGSL 300
Query: 365 ILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVE 410
LS + LELP V +D+GE+ C A+N G + + +LS++
Sbjct: 301 TLSPSQSSNLGVLELPRVHVKDEGEFTCRAQNPLGSQHISLSLSLQ 346
>gi|16506828 sialic acid binding immunoglobulin-like lectin-like
protein 1 isoform a precursor [Homo sapiens]
Length = 595
Score = 118 bits (296), Expect = 1e-26
Identities = 95/385 (24%), Positives = 162/385 (42%), Gaps = 41/385 (10%)
Query: 26 MPSSISAFEGTCVSIPCRFDFP--DELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHE 83
+P S++ EG CVS+PC +P + + V+G W+ PV + + V E
Sbjct: 155 VPESVTVQEGLCVSVPCSVLYPHYNWTASSPVYGSWFKEGADIPWDIPVATNTPSGKVQE 214
Query: 84 SFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYN-QYTFSEHS--VLDIVNT 140
GR LLGD NC+L + + GKYYF+ + G Y + + S V + +
Sbjct: 215 DTHGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVERGSRKWNYIYDKLSVHVTALTHM 274
Query: 141 PNIVVPPEVVAGTEVEVSCMVPDNCPE-LRPELSWLGHEGLGEPAVLGRLREDEGTWVQV 199
P +P + +G ++C VP C + P ++W+G + + T +
Sbjct: 275 PTFSIPGTLESGHPRNLTCSVPWACEQGTPPTITWMG----------ASVSSLDPTITRS 324
Query: 200 SLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEM-------------- 245
S+L +P + +G L CQ + P + +++ YPP + M
Sbjct: 325 SMLSLIPQPQDHGTSLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLR 384
Query: 246 -NSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESL-LLELEEVTPAEDGVY 303
S++ +EG + L+C DSNPP L+W L + + +L +LEL V ++G +
Sbjct: 385 NGSALSVLEGQSLHLVCAVDSNPPARLSWTWGSLTLSPSQSSNLGVLELPRVHVKDEGEF 444
Query: 304 ACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEK 363
C A+N G + ++ LS+ + G M + G T+ +F
Sbjct: 445 TCRAQNPLGSQHISLSLSL-----QNEYTGKMRPISGVTLGAF----GGAGATALVFLYF 495
Query: 364 QILSTVIYESELQLELPAVSPEDDG 388
I+ V+ + PAV D G
Sbjct: 496 CIIFVVVRSCRKKSARPAVGVGDTG 520
Score = 83.2 bits (204), Expect = 7e-16
Identities = 111/469 (23%), Positives = 180/469 (38%), Gaps = 66/469 (14%)
Query: 1 MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAV--VHGV 58
++ L PL + A + M S++ EG CVS+ C F +P A VHG
Sbjct: 3 LLLLLLPPLLCGRVGAKEQKDYLLTMQKSVTVQEGLCVSVLCSFSYPQNGWTASDPVHGY 62
Query: 59 WYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFR 118
W+ + PV + + V E + R LLGD ++CTL + + G Y F
Sbjct: 63 WFRAGDHVSRNIPVATNNPARAVQEETRDRFHLLGDPQNKDCTLSIRDTRESDAGTYVFC 122
Query: 119 GDLGG------YNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPEL 172
+ G Y+Q + + + D+++ + VP V V+ V C L P
Sbjct: 123 VERGNMKWNYKYDQLSVNVTASQDLLSRYRLEVPESVT----VQEGLCVSVPCSVLYPHY 178
Query: 173 SWLG---------HEGLGEP--------AVLGRLREDEGTWVQVSLLHFVPTREAN-GHR 214
+W EG P G+++ED T + LL T + R
Sbjct: 179 NWTASSPVYGSWFKEGADIPWDIPVATNTPSGKVQED--THGRFLLLGDPQTNNCSLSIR 236
Query: 215 LGCQASFPNTTLQFE-GYASMDVKYPPVIVEMNSSVE--------AIEGSHV-SLLC--- 261
+ Q E G + Y + V + + +E H +L C
Sbjct: 237 DARKGDSGKYYFQVERGSRKWNYIYDKLSVHVTALTHMPTFSIPGTLESGHPRNLTCSVP 296
Query: 262 -GADSNPPPLLTWM-RDGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQD---NR 316
+ PP +TWM + L + S +L L P + G G R
Sbjct: 297 WACEQGTPPTITWMGASVSSLDPTITRSSMLSLIP-QPQDHGTSLTCQVTLPGAGVTMTR 355
Query: 317 TVGLSVMYAPWKPTV--------------NGTMVAV-EGETVSILCSTQSNPDPILTIFK 361
V L++ Y P T+ NG+ ++V EG+++ ++C+ SNP L+
Sbjct: 356 AVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVCAVDSNPPARLSWTW 415
Query: 362 EKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVE 410
LS + LELP V +D+GE+ C A+N G + + +LS++
Sbjct: 416 GSLTLSPSQSSNLGVLELPRVHVKDEGEFTCRAQNPLGSQHISLSLSLQ 464
>gi|193794821 sialic acid binding Ig-like lectin 6 isoform 1
precursor [Homo sapiens]
Length = 453
Score = 115 bits (289), Expect = 9e-26
Identities = 102/363 (28%), Positives = 159/363 (43%), Gaps = 43/363 (11%)
Query: 7 LPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVV-HGVWYFNSPY 65
LPL W A + P S++ EG CV +PCR P L + +G W+
Sbjct: 17 LPLLWAGALAQER-RFQLEGPESLTVQEGLCVLVPCRL--PTTLPASYYGYGYWFLEGAD 73
Query: 66 PKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYN 125
PV + V E +GR LL D +NC+L + + Y+FR
Sbjct: 74 V----PVATNDPDEEVQEETRGRFHLLWDPRRKNCSLSIRDARRRDNAAYFFRLKSKWMK 129
Query: 126 Q-YTFSEHS--VLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPEL-SWLGHEGLG 181
YT S+ S V+ + + PNI +P + +G ++C VP C + P + SW+
Sbjct: 130 YGYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQGTPPIFSWMS----A 185
Query: 182 EPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP- 240
P LG Q S+L P + + L CQ +FP + E ++V Y P
Sbjct: 186 APTSLG------PRTTQSSVLTITPRPQDHSTNLTCQVTFPGAGVTMERTIQLNVSYAPQ 239
Query: 241 --------------VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-VA 285
I++ SS+ +EG + LLC AD NPP L+W + L ++
Sbjct: 240 KVAISIFQGNSAAFKILQNTSSLPVLEGQALRLLCDADGNPPAHLSWFQGFPALNATPIS 299
Query: 286 ESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKP--TVNGTMVAVEGETV 343
+ +LEL +V AE+G + C A++ G + + LS ++ WKP G + AV G ++
Sbjct: 300 NTGVLELPQVGSAEEGDFTCRAQHPLG--SLQISLS-LFVHWKPEGRAGGVLGAVWGASI 356
Query: 344 SIL 346
+ L
Sbjct: 357 TTL 359
Score = 50.8 bits (120), Expect = 4e-06
Identities = 50/210 (23%), Positives = 84/210 (40%), Gaps = 26/210 (12%)
Query: 230 GYAS--MDVKYPPVIVEMNSSVEA-IEGSHVS-LLCGA----DSNPPPLLTWMRDG-TVL 280
GY S + V+ + N S+ +E H S L C + PP+ +WM T L
Sbjct: 131 GYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQGTPPIFSWMSAAPTSL 190
Query: 281 REAVAESLLLELEEVTPAEDGVYACLAE--NAYGQDNRTVGLSVMYAPWKPTVN------ 332
+S +L + C A RT+ L+V YAP K ++
Sbjct: 191 GPRTTQSSVLTITPRPQDHSTNLTCQVTFPGAGVTMERTIQLNVSYAPQKVAISIFQGNS 250
Query: 333 ---------GTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVS 383
++ +EG+ + +LC NP L+ F+ L+ + LELP V
Sbjct: 251 AAFKILQNTSSLPVLEGQALRLLCDADGNPPAHLSWFQGFPALNATPISNTGVLELPQVG 310
Query: 384 PEDDGEYWCVAENQYGQRATAFNLSVEFAP 413
++G++ C A++ G + +L V + P
Sbjct: 311 SAEEGDFTCRAQHPLGSLQISLSLFVHWKP 340
>gi|157168355 CD22 molecule [Homo sapiens]
Length = 847
Score = 115 bits (288), Expect = 1e-25
Identities = 130/465 (27%), Positives = 198/465 (42%), Gaps = 38/465 (8%)
Query: 14 ISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPD-ELRPAVVHGVWYFNSPYPKNYPPV 72
++ S W P ++ A+EG CV IPC + D +L ++ + N Y KN
Sbjct: 16 LAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFIL----FHNPEYNKNTSKF 71
Query: 73 ----VFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYNQYT 128
+++S S Q R + LGD +NCTL + V G+ R +
Sbjct: 72 DGTRLYESTKDGKVPSEQKRVQFLGDKN-KNCTLSIHPVHLNDSGQLGLRMESKTEKWME 130
Query: 129 FSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEG--LGEPAVL 186
+V + P+I +PPE+ EV ++C++ +C +L WL EG + + AV
Sbjct: 131 RIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWL-LEGVPMRQAAVT 189
Query: 187 GRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMN 246
+ + + S L F P +G + CQ + ++VK+ P +
Sbjct: 190 STSLTIKSVFTR-SELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKV 248
Query: 247 SSVEAI--EGSHVSLLCGADSNPPPLLT--WMRDGTVLREAVAESLLLELEEVTPAEDGV 302
+ +AI EG V++ C S+ P T W++DGT L++ + L L EVT + G
Sbjct: 249 TPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKK--QNTFTLNLREVTKDQSGK 306
Query: 303 YACLAENAYGQD-NRTVGLSVMYAPWKPTVNGT-MVAVEGETVSILCSTQSNPDPILTIF 360
Y C N G + V L V YAP TV AVEG V LC + +NP P T +
Sbjct: 307 YCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLP--TNY 364
Query: 361 KEKQILSTVIYESELQLELPAVSPEDDGEYWCVAEN--QYGQRATAFNLSVEFAP----V 414
+ +E ++ +P + P G Y CVAEN GQR L V++ P
Sbjct: 365 TWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTT 424
Query: 415 LLLESHCAAARDTVQCLC-VVKSNP-------EPSVAFELPSRNV 451
++ DTV C SNP +P A+E PS V
Sbjct: 425 VIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGV 469
Score = 68.2 bits (165), Expect = 2e-11
Identities = 90/324 (27%), Positives = 136/324 (41%), Gaps = 34/324 (10%)
Query: 101 TLLLSNVSPELGGKYYFR--GDLG-GYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEV 157
TL L V+ + GKY + D+G G ++ F + +T I+ P V G++VE
Sbjct: 293 TLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSP-AVEGSQVEF 351
Query: 158 SCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGC 217
CM N L +W H G + GR E +H + C
Sbjct: 352 LCMSLAN--PLPTNYTWY-HNG---KEMQGRTEEK---------VHIPKILPWHAGTYSC 396
Query: 218 QASFPNTTLQFEGYASMDVKYPP--VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLT--W 273
A T Q A +DV+YPP V + + + EG V+L C +S+ P + W
Sbjct: 397 VAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEW 456
Query: 274 MRDGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNG 333
G ++ +L+++ V ++ AC A N++ V L+V YAP V
Sbjct: 457 KPHGAWEEPSLG---VLKIQNVG-WDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRK 512
Query: 334 TMVAVE---GETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEY 390
E G +VS+ C S+ + F EK + + E QL ++SPED G Y
Sbjct: 513 IKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEK---NGRLLGKESQLNFDSISPEDAGSY 569
Query: 391 WCVAENQYGQRAT-AFNLSVEFAP 413
C N GQ A+ A+ L V +AP
Sbjct: 570 SCWVNNSIGQTASKAWTLEVLYAP 593
Score = 65.5 bits (158), Expect = 1e-10
Identities = 68/278 (24%), Positives = 119/278 (42%), Gaps = 35/278 (12%)
Query: 146 PPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFV 205
P + G V +SC + P + W H EP+ LG L+ W ++
Sbjct: 429 PMPIREGDTVTLSCNYNSSNPSVT-RYEWKPHGAWEEPS-LGVLKIQNVGWDNTTI---- 482
Query: 206 PTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIE---GSHVSLLCG 262
C A N+ + +++V+Y P V + E G+ VSL C
Sbjct: 483 ----------ACAAC--NSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCD 530
Query: 263 ADSNPPPLLT--WMRDGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQD-NRTVG 319
S+ P + W ++G +L + L + ++P + G Y+C N+ GQ ++
Sbjct: 531 FSSSHPKEVQFFWEKNGRLL----GKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWT 586
Query: 320 LSVMYAPWKPTVN---GTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQ 376
L V+YAP + V+ G V +EG++ ++ C + +NP + + S + +L+
Sbjct: 587 LEVLYAPRRLRVSMSPGDQV-MEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLR 645
Query: 377 LELPAVSPEDDGEYWCVAENQYGQ-RATAFNLSVEFAP 413
LE V + G YWC N G+ R+ L+V ++P
Sbjct: 646 LE--PVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSP 681
Score = 40.0 bits (92), Expect = 0.006
Identities = 34/118 (28%), Positives = 52/118 (44%), Gaps = 8/118 (6%)
Query: 233 SMDVKYPP--VIVEMNSSVEAIEGSHVSLLCGADSNPP-PLLTWMRDGTVLREAVAESLL 289
+++V Y P + V M+ + +EG +L C +D+NPP TW + S
Sbjct: 586 TLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNN--QSLPYHSQK 643
Query: 290 LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVE-GETVSIL 346
L LE V G Y C N+ G+ + +Y + P G VAV G ++IL
Sbjct: 644 LRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVY--YSPETIGRRVAVGLGSCLAIL 699
>gi|193794819 sialic acid binding Ig-like lectin 6 isoform 2
precursor [Homo sapiens]
Length = 437
Score = 114 bits (285), Expect = 3e-25
Identities = 100/348 (28%), Positives = 157/348 (45%), Gaps = 29/348 (8%)
Query: 7 LPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVV-HGVWYFNSPY 65
LPL W A + P S++ EG CV +PCR P L + +G W+
Sbjct: 17 LPLLWAGALAQER-RFQLEGPESLTVQEGLCVLVPCRL--PTTLPASYYGYGYWFLEGAD 73
Query: 66 PKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYN 125
PV + V E +GR LL D +NC+L + + Y+FR
Sbjct: 74 V----PVATNDPDEEVQEETRGRFHLLWDPRRKNCSLSIRDARRRDNAAYFFRLKSKWMK 129
Query: 126 Q-YTFSEHS--VLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPEL-SWLGHEGLG 181
YT S+ S V+ + + PNI +P + +G ++C VP C + P + SW+
Sbjct: 130 YGYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQGTPPIFSWMS----A 185
Query: 182 EPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPV 241
P LG Q S+L P + + L CQ +FP + E ++V
Sbjct: 186 APTSLG------PRTTQSSVLTITPRPQDHSTNLTCQVTFPGAGVTMERTIQLNVS-SFK 238
Query: 242 IVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-VAESLLLELEEVTPAED 300
I++ SS+ +EG + LLC AD NPP L+W + L ++ + +LEL +V AE+
Sbjct: 239 ILQNTSSLPVLEGQALRLLCDADGNPPAHLSWFQGFPALNATPISNTGVLELPQVGSAEE 298
Query: 301 GVYACLAENAYGQDNRTVGLSVMYAPWKP--TVNGTMVAVEGETVSIL 346
G + C A++ G + + LS ++ WKP G + AV G +++ L
Sbjct: 299 GDFTCRAQHPLG--SLQISLS-LFVHWKPEGRAGGVLGAVWGASITTL 343
Score = 45.1 bits (105), Expect = 2e-04
Identities = 49/196 (25%), Positives = 82/196 (41%), Gaps = 14/196 (7%)
Query: 230 GYAS--MDVKYPPVIVEMNSSVEA-IEGSHVS-LLCGA----DSNPPPLLTWMRDG-TVL 280
GY S + V+ + N S+ +E H S L C + PP+ +WM T L
Sbjct: 131 GYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQGTPPIFSWMSAAPTSL 190
Query: 281 REAVAESLLLELEEVTPAEDGVYACLAE--NAYGQDNRTVGLSVMYAPWKPTVNGTMVAV 338
+S +L + C A RT+ L+V + +K N + + V
Sbjct: 191 GPRTTQSSVLTITPRPQDHSTNLTCQVTFPGAGVTMERTIQLNV--SSFKILQNTSSLPV 248
Query: 339 -EGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQ 397
EG+ + +LC NP L+ F+ L+ + LELP V ++G++ C A++
Sbjct: 249 LEGQALRLLCDADGNPPAHLSWFQGFPALNATPISNTGVLELPQVGSAEEGDFTCRAQHP 308
Query: 398 YGQRATAFNLSVEFAP 413
G + +L V + P
Sbjct: 309 LGSLQISLSLFVHWKP 324
>gi|148762980 sialic acid binding Ig-like lectin 14 [Homo sapiens]
Length = 396
Score = 110 bits (274), Expect = 5e-24
Identities = 93/348 (26%), Positives = 145/348 (41%), Gaps = 38/348 (10%)
Query: 1 MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFP--DELRPAVVHGV 58
M+ L LPL W S + + S++ EG CV +PC F +P ++
Sbjct: 1 MLPLLLLPLLWGG-SLQEKPVYELQVQKSVTVQEGLCVLVPCSFSYPWRSWYSSPPLYVY 59
Query: 59 WYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFR 118
W+ + P V + + V QGR RLLGD+ +NC+L + + E G Y+FR
Sbjct: 60 WFRDGEIPYYAEVVATNNPDRRVKPETQGRFRLLGDVQKKNCSLSIGDARMEDTGSYFFR 119
Query: 119 GDLGGYNQYTFSEH----SVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPEL-- 172
+ G +Y++ ++ V ++ P+I + +G +SC +P +C E P L
Sbjct: 120 VERGRDVKYSYQQNKLNLEVTALIEKPDIHFLEPLESGRPTRLSCSLPGSC-EAGPPLTF 178
Query: 173 SWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYA 232
SW G+ L + + S L P E +G L CQ + E
Sbjct: 179 SWTGN----------ALSPLDPETTRSSELTLTPRPEDHGTNLTCQVKRQGAQVTTERTV 228
Query: 233 SMDVKYPPV-----------------IVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMR 275
++V Y P I+ SV EG + L C DSNPP L+W R
Sbjct: 229 QLNVSYAPQNLAISIFFRNGTGTALRILSNGMSVPIQEGQSLFLACTVDSNPPASLSWFR 288
Query: 276 DGTVLREA-VAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSV 322
+G L + + S LEL + E G + C ++ G + + LSV
Sbjct: 289 EGKALNPSQTSMSGTLELPNIGAREGGEFTCRVQHPLGSQHLSFILSV 336
Score = 52.4 bits (124), Expect = 1e-06
Identities = 50/200 (25%), Positives = 80/200 (40%), Gaps = 38/200 (19%)
Query: 258 SLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDGVYACLA-----ENAYG 312
SL ++ PP +W G L E+ +TP + L + A
Sbjct: 165 SLPGSCEAGPPLTFSWT--GNALSPLDPETTRSSELTLTPRPEDHGTNLTCQVKRQGAQV 222
Query: 313 QDNRTVGLSVMYAPWKPTV-----NGTMVAV------------EGETVSILCSTQSNPDP 355
RTV L+V YAP + NGT A+ EG+++ + C+ SNP
Sbjct: 223 TTERTVQLNVSYAPQNLAISIFFRNGTGTALRILSNGMSVPIQEGQSLFLACTVDSNPPA 282
Query: 356 ILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL 415
L+ F+E + L+ LELP + + GE+ C ++ G + +F LSV+
Sbjct: 283 SLSWFREGKALNPSQTSMSGTLELPNIGAREGGEFTCRVQHPLGSQHLSFILSVQ----- 337
Query: 416 LLESHCAAARDTVQCLCVVK 435
R + C+CV +
Sbjct: 338 ---------RSSSSCICVTE 348
>gi|193794817 sialic acid binding Ig-like lectin 6 isoform 3
precursor [Homo sapiens]
Length = 353
Score = 109 bits (272), Expect = 9e-24
Identities = 94/340 (27%), Positives = 147/340 (43%), Gaps = 38/340 (11%)
Query: 7 LPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVV-HGVWYFNSPY 65
LPL W A + P S++ EG CV +PCR P L + +G W+
Sbjct: 17 LPLLWAGALAQER-RFQLEGPESLTVQEGLCVLVPCRL--PTTLPASYYGYGYWFLEGAD 73
Query: 66 PKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYN 125
PV + V E +GR LL D +NC+L + + Y+FR
Sbjct: 74 V----PVATNDPDEEVQEETRGRFHLLWDPRRKNCSLSIRDARRRDNAAYFFRLKSKWMK 129
Query: 126 Q-YTFSEHS--VLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPEL-SWLGHEGLG 181
YT S+ S V+ + + PNI +P + +G ++C VP C + P + SW+
Sbjct: 130 YGYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQGTPPIFSWMS----A 185
Query: 182 EPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP- 240
P LG Q S+L P + + L CQ +FP + E ++V Y P
Sbjct: 186 APTSLG------PRTTQSSVLTITPRPQDHSTNLTCQVTFPGAGVTMERTIQLNVSYAPQ 239
Query: 241 --------------VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-VA 285
I++ SS+ +EG + LLC AD NPP L+W + L ++
Sbjct: 240 KVAISIFQGNSAAFKILQNTSSLPVLEGQALRLLCDADGNPPAHLSWFQGFPALNATPIS 299
Query: 286 ESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYA 325
+ +LEL +V AE+G + C A++ G ++ L V ++
Sbjct: 300 NTGVLELPQVGSAEEGDFTCRAQHPLGSLQISLSLFVHWS 339
Score = 50.1 bits (118), Expect = 6e-06
Identities = 50/217 (23%), Positives = 87/217 (40%), Gaps = 26/217 (11%)
Query: 230 GYAS--MDVKYPPVIVEMNSSVEA-IEGSHVS-LLCGA----DSNPPPLLTWMRDG-TVL 280
GY S + V+ + N S+ +E H S L C + PP+ +WM T L
Sbjct: 131 GYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQGTPPIFSWMSAAPTSL 190
Query: 281 REAVAESLLLELEEVTPAEDGVYACLAE--NAYGQDNRTVGLSVMYAPWKPTVN------ 332
+S +L + C A RT+ L+V YAP K ++
Sbjct: 191 GPRTTQSSVLTITPRPQDHSTNLTCQVTFPGAGVTMERTIQLNVSYAPQKVAISIFQGNS 250
Query: 333 ---------GTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVS 383
++ +EG+ + +LC NP L+ F+ L+ + LELP V
Sbjct: 251 AAFKILQNTSSLPVLEGQALRLLCDADGNPPAHLSWFQGFPALNATPISNTGVLELPQVG 310
Query: 384 PEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESH 420
++G++ C A++ G + +L V ++ + + H
Sbjct: 311 SAEEGDFTCRAQHPLGSLQISLSLFVHWSSAPVPDRH 347
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 99.0 bits (245), Expect = 1e-20
Identities = 106/388 (27%), Positives = 162/388 (41%), Gaps = 48/388 (12%)
Query: 142 NIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGL-----GEPAV---LGRLRE-D 192
NI VPP + E+ ++ N L E S + L G P + +GR+R
Sbjct: 2190 NIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILS 2249
Query: 193 EGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAI 252
G +Q+S+ +++ C AS T + E ++ V P I S I
Sbjct: 2250 GGRQLQISI-----AEKSDAALYSCVASNVAGTAKKE--YNLQVYIRPTITNSGSHPTEI 2302
Query: 253 ---EGSHVSLLCGADSNPPPLLTWMRDGTVLREA-----VAESLLLELEEVTPAEDGVYA 304
G +SL C PPP +TWM+DG L +A + E +L+L+ + ++ G Y
Sbjct: 2303 IVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYV 2362
Query: 305 CLAENAYGQDNRTVGLSVMYAPWKPTVNG------TMVAVEGETVSILCSTQSNPDPILT 358
C+A N G ++ LSV +AP P++ G + VE +VS+ C P P +T
Sbjct: 2363 CVAVNVAGMTDKKYDLSV-HAP--PSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSIT 2419
Query: 359 IFKEKQIL----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPV 414
FK+ + S I L L + ED G+Y CV N G+ F LSV P
Sbjct: 2420 WFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPH 2479
Query: 415 LL----LESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVL 470
++ LE + +V C V NP P + + + + E E + S L +
Sbjct: 2480 IVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQ--PLQEDEAHHIISGGRFLQI 2537
Query: 471 TSILTLRGQAQAPPRVICTARNLYGAKS 498
T++ Q R C A + G KS
Sbjct: 2538 TNV-----QVPHTGRYTCLASSPAGHKS 2560
Score = 94.0 bits (232), Expect = 4e-19
Identities = 95/367 (25%), Positives = 163/367 (44%), Gaps = 47/367 (12%)
Query: 142 NIVVPPEVVAGTEVEVSCMVPDNCPELR--------PELSWLGHEGLGEPAVLGR--LRE 191
N+ VPP V+ G + E +V +N L P+LSWL +E +P L L
Sbjct: 2959 NVHVPPSVI-GPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNE---QPIKLNTNTLIV 3014
Query: 192 DEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSS--- 248
G +Q+ + + ++G C A N + + S+ V PP I + +S
Sbjct: 3015 PGGRTLQI-----IRAKVSDGGEYTCIAI--NQAGESKKKFSLTVYVPPSIKDHDSESLS 3067
Query: 249 -VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-----VAESLLLELEEVTPAEDGV 302
V EG+ VSL C +++ PPP++TW ++G ++ E+ +A+ +L +++ ++ G
Sbjct: 3068 VVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQ 3127
Query: 303 YACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVS----ILCSTQSNPDPILT 358
Y C A N G+D++ L+V Y P P++ G V ET+S + C P P +
Sbjct: 3128 YVCRAINVAGRDDKNFHLNV-YVP--PSIEGPEREVIVETISNPVTLTCDATGIPPPTIA 3184
Query: 359 IFK-EKQI-----LSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFA 412
K K+I L I +L++ D G Y C+A N G+ + LS++
Sbjct: 3185 WLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVP 3244
Query: 413 PVL----LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGL 468
P + + + V+ +C P P + + + + E+ER V + S L
Sbjct: 3245 PSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTL 3304
Query: 469 VLTSILT 475
+ LT
Sbjct: 3305 NIYGALT 3311
Score = 91.7 bits (226), Expect = 2e-18
Identities = 88/366 (24%), Positives = 141/366 (38%), Gaps = 37/366 (10%)
Query: 149 VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTR 208
V+AG EV + C V P P ++W L P T++ + TR
Sbjct: 1091 VLAGEEVTLPCEVKSLPP---PIITWAKETQLISPF------SPRHTFLPSGSMKITETR 1141
Query: 209 EANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPP 268
++ C A+ N ++V PP I ++ G V + C A P
Sbjct: 1142 TSDSGMYLCVAT--NIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPL 1199
Query: 269 PLLTWMRDGTVL-----REAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVM 323
P++TW + G+ + L +++ TP++ G+Y C+A N G D + L V
Sbjct: 1200 PVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQ 1259
Query: 324 YAPW----KPTVNGTMVA-VEGETVSILCSTQSNPDPILTIFKEKQILS-----TVIYES 373
P +P N T V + + C + P P + + L+ I E
Sbjct: 1260 EPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILED 1319
Query: 374 ELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL----LLESHCAAARDTVQ 429
L + +V+P D+GEY CVA N+ G +NL V PV+ + +
Sbjct: 1320 GTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTN 1379
Query: 430 CLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQAQAPPRVICT 489
C V+ P P + + NV V ES + + +G +L R + R C
Sbjct: 1380 LFCEVEGTPSPIIMWY--KDNVQVTESST--IQTVNNGKILK---LFRATPEDAGRYSCK 1432
Query: 490 ARNLYG 495
A N+ G
Sbjct: 1433 AINIAG 1438
Score = 85.5 bits (210), Expect = 1e-16
Identities = 91/370 (24%), Positives = 156/370 (42%), Gaps = 46/370 (12%)
Query: 70 PPVVFKSRTQVVHESFQGRSRLLG-------DLGLRNCTLLLSNVSPELGGKYYFRGDLG 122
P +++K + V GR R+L + ++ L S V+ + G
Sbjct: 2226 PNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKE---- 2281
Query: 123 GYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGE 182
YN + ++ + + P ++ V G + + C V P P ++W+ G
Sbjct: 2282 -YNLQVYIRPTITNSGSHPTEII---VTRGKSISLECEVQGIPP---PTVTWMKD---GH 2331
Query: 183 PAVLGRLRE--DEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP 240
P + + E DEG +Q+ +H T R C A N + + V PP
Sbjct: 2332 PLIKAKGVEILDEGHILQLKNIHVSDTG-----RYVCVAV--NVAGMTDKKYDLSVHAPP 2384
Query: 241 VIVEMNSSVE---AIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-----LEL 292
I+ + S E +E + VSL C A P P +TW +DG + + + +L L L
Sbjct: 2385 SIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRILSGGRMLRL 2444
Query: 293 EEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPW---KPTVNGTMVAVEGETVSILCST 349
+ T + G Y C+ NA G++ + GLSV+ P + T+ V E ++V++ C
Sbjct: 2445 MQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVK-EKQSVTLTCEV 2503
Query: 350 QSNPDPILTIFKEKQILSTV----IYESELQLELPAVSPEDDGEYWCVAENQYGQRATAF 405
NP P +T K+ Q L I L++ V G Y C+A + G ++ +F
Sbjct: 2504 TGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSF 2563
Query: 406 NLSVEFAPVL 415
+L+V +P +
Sbjct: 2564 SLNVFVSPTI 2573
Score = 85.1 bits (209), Expect = 2e-16
Identities = 72/272 (26%), Positives = 110/272 (40%), Gaps = 13/272 (4%)
Query: 234 MDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVL----REAVAESLL 289
+ V+ PP + M + GS VS++C A P P + W + + R +
Sbjct: 606 LTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGT 665
Query: 290 LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCST 349
L ++ P + G+Y CLA N+ G D + L + AP V ++ G+ + C T
Sbjct: 666 LFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGDITVMECKT 725
Query: 350 QSNPDPILTIFKEKQIL--STVIYESEL--QLELPAVSPEDDGEYWCVAENQYGQRATAF 405
P P + FK L ST + L L++ D G+Y CVA N+ G+
Sbjct: 726 SGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKI 785
Query: 406 NLSVEFAPVLLLESHCAAAR--DTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYS 463
L V PV + E + V C V+ PEP++ + R + R F S
Sbjct: 786 TLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWR---RLDNMPIFSRPFSVS 842
Query: 464 ERSGLVLTSILTLRGQAQAPPRVICTARNLYG 495
S L ++ L A IC A N +G
Sbjct: 843 SISQLRTGALFILNLWASDKGTYICEAENQFG 874
Score = 83.6 bits (205), Expect = 5e-16
Identities = 99/409 (24%), Positives = 163/409 (39%), Gaps = 59/409 (14%)
Query: 59 WYFNSPYPKNYPPVVFKSRTQVVH-ESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYF 117
WY ++ + F +R Q++ ES Q + D G+ C + S + EL
Sbjct: 1954 WYKDNRLLSGSTSMTFLNRGQIIDIESAQ-----ISDAGIYKCVAINSAGATELF----- 2003
Query: 118 RGDLGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGH 177
Y+ H I + N+V VV V + C P P L+WL
Sbjct: 2004 ---------YSLQVHVAPSISGSNNMVA---VVVNNPVRLECEAR-GIPA--PSLTWL-K 2047
Query: 178 EGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVK 237
+G + L+ G +L + ++ R C A N + + + V
Sbjct: 2048 DGSPVSSFSNGLQVLSGG----RILALTSAQISDTGRYTCVAV--NAAGEKQRDIDLRVY 2101
Query: 238 YPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESL-----LLEL 292
PP I+ +V + V LLC +D+ PPP LTW++DG L + S+ +L++
Sbjct: 2102 VPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKI 2161
Query: 293 EEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGT-----MVAVEGETVSILC 347
E+ + G Y C A N G+ + +++ + P P + G+ + +EG +S+LC
Sbjct: 2162 EDAQVQDTGRYTCEATNVAGKTEKNYNVNI-WVP--PNIGGSDELTQLTVIEGNLISLLC 2218
Query: 348 STQSNPDPILTIFKEK-------QILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQ 400
+ P P L I+K+K + I QL++ D Y CVA N G
Sbjct: 2219 ESSGIPPPNL-IWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGT 2277
Query: 401 RATAFNLSVEFAPVLLLE-SH----CAAARDTVQCLCVVKSNPEPSVAF 444
+NL V P + SH ++ C V+ P P+V +
Sbjct: 2278 AKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTW 2326
Score = 80.9 bits (198), Expect = 3e-15
Identities = 98/422 (23%), Positives = 163/422 (38%), Gaps = 55/422 (13%)
Query: 101 TLLLSNVSPELGGKYYFRGDLGGYNQYTFSEHSVLDIVNTPNIVVPPE---VVAGTEVEV 157
TL + N +P+ G Y G L + T ++S L + P ++V V G +
Sbjct: 665 TLFIKNAAPKDAGIY---GCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGDITVM 721
Query: 158 SCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVS----LLHFVPTREANGH 213
C P P++ W G L T++ + LL T++ +
Sbjct: 722 ECKTSGIPP---PQVKWFK----------GDLELRPSTFLIIDPLLGLLKIQETQDLDAG 768
Query: 214 RLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTW 273
C A N + G ++DV PPV ++ + V GS+V+L C P P + W
Sbjct: 769 DYTCVAI--NEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKW 826
Query: 274 MR--DGTVLREAVAESLLLELE-------EVTPAEDGVYACLAENAYG--QDNRTVGLSV 322
R + + + S + +L + ++ G Y C AEN +G Q TV ++
Sbjct: 827 RRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTG 886
Query: 323 MYAPWKPTVNGTMVAVEGETVSILCSTQS-NPDPILTIFKEKQILSTVIY---ESELQLE 378
+ AP +EG+ +++ C+ + NP P K +L Y S+ L
Sbjct: 887 LVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLH 946
Query: 379 LPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAAARDTVQCL-----CV 433
+ V +D GEY CVA N G ++ V P + H T++ + C
Sbjct: 947 IERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTI---QHGQQILSTIEGIPVTLPCK 1003
Query: 434 VKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQAQAPPRVICTARNL 493
NP+PSV + + ++ S +F L + S + +CTA N
Sbjct: 1004 ASGNPKPSVIWS--KKGELISTSSAKFSAGADGSLYVVS-----PGGEESGEYVCTATNT 1056
Query: 494 YG 495
G
Sbjct: 1057 AG 1058
Score = 79.7 bits (195), Expect = 7e-15
Identities = 59/223 (26%), Positives = 100/223 (44%), Gaps = 12/223 (5%)
Query: 231 YASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVL-----REAVA 285
+ ++ V PPVI S + I + + L C A P P +TW ++G + AV
Sbjct: 3979 HVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVL 4038
Query: 286 ESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAP-WKPTVNGTMVAVEGETVS 344
S L++ + G Y C+A+N G + L+V P P + ++AV+ + ++
Sbjct: 4039 PSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVD-KPIT 4097
Query: 345 ILCSTQSNPDPILTIFKEKQILSTVIYESEL---QLELPAVSPEDDGEYWCVAENQYGQR 401
+ C P P +T K+ + + I + L L++ V P D G Y C+A N G
Sbjct: 4098 LSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSS 4157
Query: 402 ATAFNLSVEFAP-VLLLESHCAAARDTVQCL-CVVKSNPEPSV 442
+T+ L+V P + E H ++ L CV P P++
Sbjct: 4158 STSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAI 4200
Score = 79.7 bits (195), Expect = 7e-15
Identities = 66/238 (27%), Positives = 96/238 (40%), Gaps = 14/238 (5%)
Query: 234 MDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL---- 289
+ V PP I E S L C AD P P + W +D +L + +
Sbjct: 4163 LTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYG 4222
Query: 290 -LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCS 348
L LE V + G Y C+A NA G+D TV L+V P + G + +GE + + C
Sbjct: 4223 ELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCK 4282
Query: 349 TQSNPDPILTIFKEKQIL----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATA 404
P P LT I+ +V SEL +E VS ED G Y C AEN G
Sbjct: 4283 ATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIE--RVSKEDSGTYVCTAENSVGFVKAI 4340
Query: 405 FNLSVEFAPVL---LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESERE 459
+ V+ PV + C VK +P P++ + ++ ++ R+
Sbjct: 4341 GFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQ 4398
Score = 77.0 bits (188), Expect = 5e-14
Identities = 100/397 (25%), Positives = 151/397 (38%), Gaps = 66/397 (16%)
Query: 93 GDLGLRNCTLLLSNVSPELGG-KYYFRGDL--GGYNQYTFSEHS------VLDIVNTPNI 143
GDL LR T L+ + P LG K DL G Y +E LD+ + P
Sbjct: 738 GDLELRPSTFLI--IDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVF 795
Query: 144 VVPPEVVA---GTEVEVSCMVP------------DNCPEL-RP-ELSWLGHEGLGEPAVL 186
+ P V+ G+ V + C V DN P RP +S + G +L
Sbjct: 796 IQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFIL 855
Query: 187 GRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMN 246
D+GT++ C+A +Q E ++ P+I
Sbjct: 856 NLWASDKGTYI-------------------CEAENQFGKIQSETTVTVTGLVAPLIGISP 896
Query: 247 SSVEAIEGSHVSLLCGA-DSNPPPLLTWMRDGTVLRE----AVAESLLLELEEVTPAEDG 301
S IEG ++L C NP P W+++ +L + V L +E V + G
Sbjct: 897 SVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQLQDGG 956
Query: 302 VYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFK 361
Y C+A N G +N+T + V P + +EG V++ C NP P + K
Sbjct: 957 EYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSK 1016
Query: 362 EKQILST--VIYESELQLELPAVSP--EDDGEYWCVAENQYGQRATAFNLSVEFAPVLLL 417
+ +++ST + + L VSP E+ GEY C A N G L+V P +
Sbjct: 1017 KGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFG 1076
Query: 418 ESH----------CAAARDTVQCLCVVKSNPEPSVAF 444
+ A + V C VKS P P + +
Sbjct: 1077 DQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITW 1113
Score = 76.3 bits (186), Expect = 8e-14
Identities = 94/408 (23%), Positives = 161/408 (39%), Gaps = 43/408 (10%)
Query: 120 DLGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPEL--------RPE 171
D G Y S +I +++VPP + G E ++ +N EL P
Sbjct: 1706 DRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPT 1765
Query: 172 LSWLGHEGLGEPAVLGRLREDEGTWVQVS--LLHFVPTREANGHRLGCQASFPNTTLQFE 229
+ WL L + E +G + ++ L + +N C A+ NT +
Sbjct: 1766 IMWLKDGQL--------IDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAA--NTAGDHK 1815
Query: 230 GYASMDVKYPPVIVEMNSSVE-AIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA----- 283
+ V PP I S ++ V+L C A+ P P +TW++D + A
Sbjct: 1816 KEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLK 1875
Query: 284 -VAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTM--VAVEG 340
+ +L++ + + G Y C+A NA G+ + + L V P + +
Sbjct: 1876 IQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVS 1935
Query: 341 ETVSILCSTQSNPDPILTIFKEKQILS-----TVIYESELQLELPAVSPEDDGEYWCVAE 395
V + C NP P++T +K+ ++LS T + ++ +++ + D G Y CVA
Sbjct: 1936 NPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQI-IDIESAQISDAGIYKCVAI 1994
Query: 396 NQYGQRATAFNLSVEFAPVLLLESHCAA--ARDTVQCLCVVKSNPEPSVAFELPSRNVTV 453
N G ++L V AP + ++ A + V+ C + P PS+ + L +
Sbjct: 1995 NSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTW-LKDGSPVS 2053
Query: 454 NESEREFVYSERSGLVLTSILTLRGQAQAPPRVICTARNLYGAKSLEL 501
+ S V S L LTS Q R C A N G K ++
Sbjct: 2054 SFSNGLQVLSGGRILALTS-----AQISDTGRYTCVAVNAAGEKQRDI 2096
Score = 76.3 bits (186), Expect = 8e-14
Identities = 63/260 (24%), Positives = 110/260 (42%), Gaps = 20/260 (7%)
Query: 201 LLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVE--AIEGSHVS 258
+L T + R C A+ N + + + + V PP + + + + + V
Sbjct: 1882 VLQIAKTLLEDAGRYTCVAT--NAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQ 1939
Query: 259 LLCGADSNPPPLLTWMRDGTVLREAVAESLL-----LELEEVTPAEDGVYACLAENAYGQ 313
L C A NP P++TW +D +L + + + L +++E ++ G+Y C+A N+ G
Sbjct: 1940 LECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGA 1999
Query: 314 DNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYES 373
L V AP N + V V + C + P P LT K+ +S+ + +
Sbjct: 2000 TELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSS--FSN 2057
Query: 374 ELQ-------LELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAAA-- 424
LQ L L + D G Y CVA N G++ +L V P ++ E +
Sbjct: 2058 GLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLI 2117
Query: 425 RDTVQCLCVVKSNPEPSVAF 444
V+ LC + P P++ +
Sbjct: 2118 SQAVELLCQSDAIPPPTLTW 2137
Score = 75.5 bits (184), Expect = 1e-13
Identities = 78/339 (23%), Positives = 133/339 (39%), Gaps = 51/339 (15%)
Query: 142 NIVVPPEVVAGTEVEVSCMVPDNCPELR--------PELSWLGHEGLGEPAVLGRLREDE 193
N+ VPP + G E EV N L P ++WL + R+ +
Sbjct: 3146 NVYVPPSI-EGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHK--------RIENSD 3196
Query: 194 GTWVQV----SLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIV--EMNS 247
V++ S L ++ ++ C AS N + + Y + ++ PP + E+ S
Sbjct: 3197 SLEVRILSGGSKLQIARSQHSDSGNYTCIAS--NMEGKAQKYYFLSIQVPPSVAGAEIPS 3254
Query: 248 SVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESL-------LLELEEVTPAED 300
V + G +V L+C A+ P PL+ W++DG + E + L + ++
Sbjct: 3255 DVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDT 3314
Query: 301 GVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGT------MVAVEGETVSILCSTQSNPD 354
G Y C+A N G+++R L+V PT+ G ++ + +++I C P
Sbjct: 3315 GKYTCVATNPAGEEDRIFNLNVYVT---PTIRGNKDEAEKLMTLVDTSINIECRATGTPP 3371
Query: 355 PILTIFKEKQILSTVIYESELQ----LELPAVSPEDDGEYWCVAENQYGQRATAFNLSVE 410
P + K L + L + + D Y CVA N+ G +NL V
Sbjct: 3372 PQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQV- 3430
Query: 411 FAPVLL-----LESHCAAARDTVQCLCVVKSNPEPSVAF 444
FAP + E + C+ P PS+A+
Sbjct: 3431 FAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAW 3469
Score = 75.1 bits (183), Expect = 2e-13
Identities = 59/226 (26%), Positives = 96/226 (42%), Gaps = 22/226 (9%)
Query: 249 VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVL-----REAVAESLLLELEEVTPAEDGVY 303
+ + G V+L C S PPP++TW ++ ++ R S +++ E ++ G+Y
Sbjct: 1089 ISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMY 1148
Query: 304 ACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEK 363
C+A N G + V L+V P + G+ V I C+ Q P P++T K
Sbjct: 1149 LCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGG 1208
Query: 364 QILSTVIYESELQ-------LELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL 416
ST++ + E L + +P D G Y CVA N G T L V+ P +
Sbjct: 1209 ---STMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVE 1265
Query: 417 -LES------HCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNE 455
LE A ++ C K P+P++ + R +T E
Sbjct: 1266 DLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGRE 1311
Score = 75.1 bits (183), Expect = 2e-13
Identities = 73/330 (22%), Positives = 138/330 (41%), Gaps = 44/330 (13%)
Query: 202 LHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMN--------SSVEAIE 253
L + +E N R C A+ N + + + V PP+I + + V+
Sbjct: 2631 LQILNAQEDNAGRYSCVAT--NEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKV 2688
Query: 254 GSHVSLLCGADSNPPPLLTWMRDGTVLRE-----AVAESLLLELEEVTPAEDGVYACLAE 308
+ ++L C A + P L+W +DG L+ A L+++E ++ G Y C+A
Sbjct: 2689 NNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVAS 2748
Query: 309 NAYGQDNRTVGLSVMYAP--WKPTVNGTMV----------AVEGETVSILCSTQSNPDPI 356
N G+D +++ P K G M+ + +S+ C T + P P
Sbjct: 2749 NIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPT 2808
Query: 357 LTIFKEKQILST----VIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFA 412
LT +K+ L++ +I L++P ED G Y CVA N+ G+ + +++ V
Sbjct: 2809 LTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVP 2868
Query: 413 PVL------LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERS 466
P++ L E + C+ +P P +++ + + + + +F+ + R
Sbjct: 2869 PIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPL-LEDDHHKFLSNGRI 2927
Query: 467 GLVLTSILTLRGQAQAPPRVICTARNLYGA 496
+L + +T G R +C A N G+
Sbjct: 2928 LQILNTQITDIG------RYVCVAENTAGS 2951
Score = 71.6 bits (174), Expect = 2e-12
Identities = 61/235 (25%), Positives = 93/235 (39%), Gaps = 29/235 (12%)
Query: 233 SMDVKYPPVIVEMNSSV-----EAIEGSHVSLLCGADSNPPPLLTWMRDGTVLR------ 281
++ V+ PP + ++ E + + C A P P + W+ +G L
Sbjct: 1255 TLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGI 1314
Query: 282 EAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPW---KPTVNGTMVAV 338
+ + LL + VTP ++G Y C+A N G R L V P K V V +
Sbjct: 1315 SILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLL 1374
Query: 339 EGETVSILCSTQSNPDPILTIFK------EKQILSTVIYESELQLELPAVSPEDDGEYWC 392
+ ++ C + P PI+ +K E + TV + L+L +PED G Y C
Sbjct: 1375 N-QLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTV--NNGKILKLFRATPEDAGRYSC 1431
Query: 393 VAENQYGQRATAFNLSVEFAPVLL-----LESHCAAARDTVQCLCVVKSNPEPSV 442
A N G FN+ V P ++ E RD V C VK P P +
Sbjct: 1432 KAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRD-VALECQVKGTPFPDI 1485
Score = 68.9 bits (167), Expect = 1e-11
Identities = 63/280 (22%), Positives = 114/280 (40%), Gaps = 19/280 (6%)
Query: 233 SMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLR---EAVAESLL 289
S+ V P E+ V +G + L C A P P LTW + ++ ++V
Sbjct: 4253 SLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSE 4312
Query: 290 LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAP--WKPTVNGTMVAVEGETVSILC 347
L +E V+ + G Y C AEN+ G + +G + P +K + G + C
Sbjct: 4313 LVIERVSKEDSGTYVCTAENSVGFV-KAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNC 4371
Query: 348 STQSNPDPILTIFKEK---QILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATA 404
+ +P P + ++ +I + L + ED G+Y CVA N+ G +
Sbjct: 4372 EVKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERS 4431
Query: 405 FNLSVEFAPVLLLE--SHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVY 462
+L+++ P++ LE A + C P+P++ + +++ + +R V
Sbjct: 4432 MSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWD--DRVNVL 4489
Query: 463 SERSGLVLTSILTLRGQAQAPPRVICTARNLYGAKSLELP 502
S S+ Q + C ARNL G+ + +P
Sbjct: 4490 SN------NSLYIADAQKEDTSEFECVARNLMGSVLVRVP 4523
Score = 68.6 bits (166), Expect = 2e-11
Identities = 69/285 (24%), Positives = 115/285 (40%), Gaps = 34/285 (11%)
Query: 148 EVVAGTEVEVSCMVPDNCPELRPELSWL--GHEGLGEPAVLGRLREDEGTWVQVSLLHFV 205
E VA +E C +P + WL G E G + L ++GT + ++ +
Sbjct: 1277 ERVANQRIEFPCPAKGTP---KPTIKWLHNGRELTGREPGISIL--EDGTLLVIASV--- 1328
Query: 206 PTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIV--EMNSSVEAIEGSHVSLLCGA 263
T NG + + TT E ++ V PPVI E ++V + +L C
Sbjct: 1329 -TPYDNGEYICVAVNEAGTT---ERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEV 1384
Query: 264 DSNPPPLLTWMRDGTVLREA-----VAESLLLELEEVTPAEDGVYACLAENAYGQDNRTV 318
+ P P++ W +D + E+ V +L+L TP + G Y+C A N G +
Sbjct: 1385 EGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYF 1444
Query: 319 GLSVMYAPWKPTVNGT-----MVAVEGETVSILCSTQSNPDPILTIFKEKQIL-----ST 368
+ V+ P T+ GT + V V++ C + P P + FK+ + L +
Sbjct: 1445 NIDVLVPP---TIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNV 1501
Query: 369 VIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAP 413
+ + L L D G Y C N G++A L++ P
Sbjct: 1502 ELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPP 1546
Score = 68.2 bits (165), Expect = 2e-11
Identities = 78/309 (25%), Positives = 130/309 (42%), Gaps = 52/309 (16%)
Query: 142 NIVVPPEVVAGTEVE-----------VSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLR 190
+++VPP +V +E ++C V N PE++W H+ G+P L+
Sbjct: 2473 SVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPV---PEITW--HKD-GQP-----LQ 2521
Query: 191 EDEGTWVQVS--LLHFVPTREANGHRLGCQASFP--NTTLQFEGYASMDVKYPPVIVEMN 246
EDE + L + + R C AS P + + F S++V P I +
Sbjct: 2522 EDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSF----SLNVFVSPTIAGVG 2577
Query: 247 SS-----VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-----LELEEVT 296
S V I S SL+C A S PP +TW +DGT L +L L++
Sbjct: 2578 SDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQ 2637
Query: 297 PAEDGVYACLAENAYGQDNRTVGLSVMYAP-------WKPTVNGTMVAVE-GETVSILCS 348
G Y+C+A N G+ + + V P W P ++ V ++ T+++ C
Sbjct: 2638 EDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECE 2697
Query: 349 TQSNPDPILTIFKEKQILST----VIYESELQLELPAVSPEDDGEYWCVAENQYGQRATA 404
+ P L+ +K+ Q L + I + L++ D G Y CVA N G+
Sbjct: 2698 AYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELD 2757
Query: 405 FNLSVEFAP 413
F+++++ P
Sbjct: 2758 FDVNIQVPP 2766
Score = 68.2 bits (165), Expect = 2e-11
Identities = 79/363 (21%), Positives = 146/363 (40%), Gaps = 33/363 (9%)
Query: 130 SEHSVLDIVNTPNIVVPPE-----VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPA 184
S+H +L ++ P+I E V+ +E++C + P P+++W+ +G P
Sbjct: 3516 SKHFILKVLEPPHINGSEEHEEISVIVNNPLELTC-IASGIPA--PKMTWM-KDGRPLPQ 3571
Query: 185 VLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVE 244
G +++S T R C AS P E + V PP I
Sbjct: 3572 TDQVQTLGGGEVLRISTAQVEDTG-----RYTCLASSPAGDDDKEYLVRVHV--PPNIAG 3624
Query: 245 MNS--SVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-----LELEEVTP 297
+ + + V+L C +D+ PPP++TW+R+G L+ +L L++
Sbjct: 3625 TDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRILSGGRYLQINNADL 3684
Query: 298 AEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPIL 357
+ Y C+A N G+ R L+V P ++V + ++ + C + P P +
Sbjct: 3685 GDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRI 3744
Query: 358 TIFKEKQILS------TVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEF 411
T K+ +L+ +++ L ++ V+ D G Y C+A N G +L V
Sbjct: 3745 TWRKDGAVLAGNHARYSILENGFLHIQSAHVT--DTGRYLCMATNAAGTDRRRIDLQVHV 3802
Query: 412 APVLLLESHCAAARDTVQ--CLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLV 469
P + VQ C P+PS+ + + V++++ + LV
Sbjct: 3803 PPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLV 3862
Query: 470 LTS 472
+ S
Sbjct: 3863 IIS 3865
Score = 67.0 bits (162), Expect = 5e-11
Identities = 54/221 (24%), Positives = 93/221 (42%), Gaps = 16/221 (7%)
Query: 250 EAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-----LELEEVTPAEDGVYA 304
+ I + +SL C ++ PPP LTW +DG L + +L L++ + G Y
Sbjct: 2788 DVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYT 2847
Query: 305 CLAENAYGQDNRTVGLSVMYAPWKPTVNGTM----VAVEGETVSILCSTQSNPDPILTIF 360
C+A N G+D+ + V+ P N + + ++ I C + +P P +
Sbjct: 2848 CVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQ 2907
Query: 361 KEKQILSTVIYESELQ----LELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL 416
K+ Q L + L L++ D G Y CVAEN G FNL+V P ++
Sbjct: 2908 KDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVI 2967
Query: 417 ---LESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVN 454
E+ + + C V P P +++ + + +N
Sbjct: 2968 GPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLN 3008
Score = 67.0 bits (162), Expect = 5e-11
Identities = 56/227 (24%), Positives = 87/227 (38%), Gaps = 23/227 (10%)
Query: 234 MDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVL-----REAVAESL 288
+ V PP I S+ + L C A+ P P +TW +DG VL R ++ E+
Sbjct: 3707 LTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENG 3766
Query: 289 LLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCS 348
L ++ + G Y C+A NA G D R + L V P M + ++ C
Sbjct: 3767 FLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACE 3826
Query: 349 TQSNPDPILTIFKEKQILSTVIYESELQL----ELPAVSP--EDDGEYWCVAENQYGQRA 402
P P + K +L+ ++ +L L +SP +D Y C N G
Sbjct: 3827 ATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDK 3886
Query: 403 TAFNLSVEFAPVL-------LLESHCAAARDTVQCLCVVKSNPEPSV 442
+L+V+ P + L+ H A C P PS+
Sbjct: 3887 RTVDLTVQVPPSIADEPTDFLVTKHAPAV-----ITCTASGVPFPSI 3928
Score = 64.7 bits (156), Expect = 2e-10
Identities = 84/382 (21%), Positives = 144/382 (37%), Gaps = 47/382 (12%)
Query: 143 IVVPPEVVAGT-----EVEVSCMVPDNCPELR----PELSWLGHEGLGEPAVLGR--LRE 191
I +PP + G V ++ ++ C E R P ++W G+P + L
Sbjct: 1542 IYIPPSIKGGNVTTDISVLINSLIKLEC-ETRGLPMPAITWYKD---GQPIMSSSQALYI 1597
Query: 192 DEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSV-- 249
D+G + LH + ++ C + N E +DV PP+I E N +
Sbjct: 1598 DKGQY-----LHIPRAQVSDSATYTCHVA--NVAGTAEKSFHVDVYVPPMI-EGNLATPL 1649
Query: 250 --EAIEGSHVSLLCGADSNPPPLLTWMRDGTVLR-----EAVAESLLLELEEVTPAEDGV 302
+ + ++L C A NP P+LTW++DG ++ A LE+ + G
Sbjct: 1650 NKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQ 1709
Query: 303 YACLAENAYGQDNRTVGLSVMYAPWKPTVNGT--MVAVEGETVSILCSTQSNPDPILTIF 360
Y C+A + G+ + V+ P + T + + + + C +P P +
Sbjct: 1710 YICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWL 1769
Query: 361 KEKQILST----VIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL 416
K+ Q++ I + +L + + G Y C+A N G F ++V P +
Sbjct: 1770 KDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIK 1829
Query: 417 ---LESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSI 473
L V C+ P PS+ + + V + + + SG VL
Sbjct: 1830 SSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKI---QSSGRVLQIA 1886
Query: 474 LTLRGQAQAPPRVICTARNLYG 495
TL A R C A N G
Sbjct: 1887 KTLLEDA---GRYTCVATNAAG 1905
Score = 61.6 bits (148), Expect = 2e-09
Identities = 59/219 (26%), Positives = 86/219 (39%), Gaps = 11/219 (5%)
Query: 235 DVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA------VAESL 288
DV PP ++++ ++V G L C S LTW R+ +R A +L
Sbjct: 515 DVSEPPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANL 574
Query: 289 LLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCS 348
LEL+ V + G Y C+ + G +V L+V P + G VSI+CS
Sbjct: 575 SLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCS 634
Query: 349 TQSNPDP-ILTIFKEKQILSTVIYE--SELQLELPAVSPEDDGEYWCVAENQYGQRATAF 405
P P I + I+ + Y S+ L + +P+D G Y C+A N G
Sbjct: 635 ATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNS 694
Query: 406 NLSVEFAPVLLL--ESHCAAARDTVQCLCVVKSNPEPSV 442
L AP L++ A D C P P V
Sbjct: 695 TLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQV 733
Score = 58.2 bits (139), Expect = 2e-08
Identities = 42/179 (23%), Positives = 72/179 (40%), Gaps = 17/179 (9%)
Query: 249 VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVL-----REAVAESLLLELEEVTPAEDGVY 303
+ ++GS S+ C D P P + W+RDG L ++L+L + + G Y
Sbjct: 3445 ITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKY 3504
Query: 304 ACLAENAYGQDNRTVGLSVMYAPWKPTVNGT-----MVAVEGETVSILCSTQSNPDPILT 358
C+A N G+ ++ L V+ P +NG+ + + + + C P P +T
Sbjct: 3505 TCIASNEAGEVSKHFILKVLE---PPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMT 3561
Query: 359 IFKEKQILSTVIYESEL----QLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAP 413
K+ + L L L + ED G Y C+A + G + + V P
Sbjct: 3562 WMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPP 3620
Score = 57.0 bits (136), Expect = 5e-08
Identities = 47/195 (24%), Positives = 85/195 (43%), Gaps = 11/195 (5%)
Query: 261 CGADSNPPPLLTWMRDGTVLRE----AVAESLLLELEEVTPAEDGVYACLAENAYGQDNR 316
C DS P L+++R+G L + S+ L++ +VT +++G Y C+A ++ G
Sbjct: 451 CSVDSLLPFTLSFVRNGVTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRA 510
Query: 317 TVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQIL-----STVIY 371
V P V + GE + C S D LT + + + + +
Sbjct: 511 QTFFDVSEPPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRT 570
Query: 372 ESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAP--VLLLESHCAAARDTVQ 429
+ L LEL +V D GEY C+ ++ G A + L+V+ P ++ ++ V
Sbjct: 571 LANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVS 630
Query: 430 CLCVVKSNPEPSVAF 444
+C P+P +A+
Sbjct: 631 IMCSATGYPKPKIAW 645
Score = 54.7 bits (130), Expect = 3e-07
Identities = 63/276 (22%), Positives = 96/276 (34%), Gaps = 22/276 (7%)
Query: 234 MDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELE 293
+ V PP I +++ I +L C A P P + W ++G +L ++ L
Sbjct: 3798 LQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLS 3857
Query: 294 E-----VTPAED--GVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSIL 346
++P+ D Y C N G D RTV L+V P + + I
Sbjct: 3858 SGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVIT 3917
Query: 347 CSTQSNPDPILTIFKEKQIL----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRA 402
C+ P P + K L S +E+ A G Y CVA N G
Sbjct: 3918 CTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAH 3977
Query: 403 TAFNLSVEFAPVLL---LESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESERE 459
L V PV+ E H + + C P P + ++ + VN S R
Sbjct: 3978 RHVTLHVHEPPVIQPQPSELH-VILNNPILLPCEATGTPSPFITWQ--KEGINVNTSGRN 4034
Query: 460 FVYSERSGLVLTSILTLRGQAQAPPRVICTARNLYG 495
GL ++ R + +C A+N G
Sbjct: 4035 HAVLPSGGLQIS-----RAVREDAGTYMCVAQNPAG 4065
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 95.9 bits (237), Expect = 1e-19
Identities = 93/353 (26%), Positives = 155/353 (43%), Gaps = 33/353 (9%)
Query: 131 EHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLR 190
+H L + +P + P VV E + + RP ++W EGL +
Sbjct: 2747 KHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQ-KEGLNVATGVSTQV 2805
Query: 191 EDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVE 250
G Q+ + H P E G+ L C A N+ G + V+ PPVI +
Sbjct: 2806 LPGG---QLRIAHASP--EDAGNYL-CIAK--NSAGSAMGKTRLVVQVPPVIENGLPDLS 2857
Query: 251 AIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-----VAESLLLELEEVTPAEDGVYAC 305
EGSH L C A +P P +TW +DG + A + S L ++ + + G Y C
Sbjct: 2858 TTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTC 2917
Query: 306 LAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQI 365
AENA G+ R V L+++ P T+ G G+ + + C+ + +P P + +
Sbjct: 2918 TAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRP 2977
Query: 366 LSTVIYESE--LQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAA 423
++ + E + L+ AVS ED G Y C AEN+ G+ + V+ APVL E+
Sbjct: 2978 VTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYL 3037
Query: 424 AR---DTVQCLCVVKSNPEPSVAF--------------ELPSRNVTVNESERE 459
++Q CVV+ +P P + + +L + ++T++ +ER+
Sbjct: 3038 VEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERD 3090
Score = 92.0 bits (227), Expect = 1e-18
Identities = 93/329 (28%), Positives = 138/329 (41%), Gaps = 35/329 (10%)
Query: 143 IVVPPEVVAGTE-------VEVSCMVPDNCPELR---PELSWLGHEGLGEPAVLGRLRED 192
++ PP ++ TE V S V CP L P +SWL + P+ ++ ED
Sbjct: 1647 VLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLED 1706
Query: 193 EGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMN-SSVEA 251
G +QVS A+ C A N E ++ V+ PP I ++ V A
Sbjct: 1707 -GQVLQVSTAEV-----ADAASYMCVAE--NQAGSAEKLFTLRVQVPPRIAGLDLEQVTA 1758
Query: 252 IEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-----LELEEVTPAEDGVYACL 306
I S VSL C ++P P +TW +D L LL L+L ++ G+Y C
Sbjct: 1759 ILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCE 1818
Query: 307 AENAYGQDNRTVGLSVMYAP-WKPTVNGTMVAV---EGETVSILCSTQSNPDPILTIFKE 362
A NA G+D + V LSV+ P ++ G AV G+ + C T + P+P +T +K+
Sbjct: 1819 ALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKD 1878
Query: 363 KQIL----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL--- 415
Q L T +LE+ D G Y C N G+ F L+V+ P
Sbjct: 1879 GQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENP 1938
Query: 416 LLESHCAAARDTVQCLCVVKSNPEPSVAF 444
E+ A + C V P P+V +
Sbjct: 1939 KTETVSQVAGSPLVLTCDVSGVPAPTVTW 1967
Score = 83.2 bits (204), Expect = 7e-16
Identities = 70/270 (25%), Positives = 112/270 (41%), Gaps = 17/270 (6%)
Query: 236 VKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-----VAESLLL 290
V PP I + + + V L C + P P ++W + G L V+ S L
Sbjct: 2662 VHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGAL 2721
Query: 291 ELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQ 350
E+ + P G Y C A N+ G ++ V L+V +P + + AV E V + C
Sbjct: 2722 EIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEAS 2781
Query: 351 SNPDPILTIFKEKQILSTVIYESEL---QLELPAVSPEDDGEYWCVAENQYGQRATAFNL 407
P P +T KE ++T + L QL + SPED G Y C+A+N G L
Sbjct: 2782 GIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRL 2841
Query: 408 SVEFAPVLL--LESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSER 465
V+ PV+ L C + +PEP++ ++ + V+ +E +F
Sbjct: 2842 VVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQ--PVSGAEGKFTIQPS 2899
Query: 466 SGLVLTSILTLRGQAQAPPRVICTARNLYG 495
L++ ++ + Q CTA N G
Sbjct: 2900 GELLVKNL-----EGQDAGTYTCTAENAVG 2924
Score = 81.6 bits (200), Expect = 2e-15
Identities = 93/419 (22%), Positives = 163/419 (38%), Gaps = 51/419 (12%)
Query: 142 NIVVPPEVVAGTEVEVSCMVPDNCPELR---------PELSWLGHEGLGEPAVLGRLRED 192
+++VPPE++ + + + P P + W E EP G ED
Sbjct: 1154 SVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGE---EPVSPG---ED 1207
Query: 193 EGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIV--EMNSSVE 250
+L T+E + C AS N + S++V PP I ++ ++
Sbjct: 1208 TYLLAGGWMLKMTQTQEQDSGLYSCLAS--NEAGEARRNFSVEVLVPPSIENEDLEEVIK 1265
Query: 251 AIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVA-----ESLLLELEEVTPAEDGVYAC 305
++G L+C +P P LTW +DG L A + +LL++ + + G Y+C
Sbjct: 1266 VLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSC 1325
Query: 306 LAENAYGQDNRTVGLSVMYAPW-----KPTVNGTMVAVEGETVSILCSTQSNPDPILTIF 360
+A NA G+ + LSV+ AP + + + + +S++C + P P +T
Sbjct: 1326 IAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWM 1385
Query: 361 KE----KQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL 416
K+ + + + L++ ED G+Y CV N+ G+ +++ V P +
Sbjct: 1386 KDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSIS 1445
Query: 417 LESHC---------AAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSG 467
+ T+ C + P P++ + + VT S R V E
Sbjct: 1446 KDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVT--PSSRLQVLGEGRL 1503
Query: 468 LVLTSILTLRGQAQAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAIL 526
L + Q R +C A N+ G + M+ K+G A AF IL
Sbjct: 1504 LQIQPT-----QVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSA--AFEIL 1555
Score = 80.9 bits (198), Expect = 3e-15
Identities = 70/286 (24%), Positives = 117/286 (40%), Gaps = 30/286 (10%)
Query: 234 MDVKYPPVIV---EMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL- 289
++V PP I E + V ++ +L C A PPP +TW RDG + + L
Sbjct: 1059 LEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQN 1118
Query: 290 ----LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAP-----WKPTVNGTMVAVEG 340
L +E A G Y+C+AEN G+ R LSV+ P P N + A
Sbjct: 1119 QGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTN--ITAALH 1176
Query: 341 ETVSILCSTQSNPDPILTIFKEKQILS----TVIYESELQLELPAVSPEDDGEYWCVAEN 396
+++LC P P + F+ ++ +S T + L++ +D G Y C+A N
Sbjct: 1177 SPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASN 1236
Query: 397 QYGQRATAFNLSVEFAPVL----LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVT 452
+ G+ F++ V P + L E T +C V +P+P + + R +
Sbjct: 1237 EAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLA 1296
Query: 453 VNESEREFVYSERSGLVLTSILTLRGQAQAPPRVICTARNLYGAKS 498
++ + G++L L+ + C A N G K+
Sbjct: 1297 RGDAH----HISPDGVLLQ---VLQANLSSAGHYSCIAANAVGEKT 1335
Score = 80.1 bits (196), Expect = 6e-15
Identities = 87/368 (23%), Positives = 153/368 (41%), Gaps = 42/368 (11%)
Query: 149 VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSL----LHF 204
V+ G EV + C P P+++WL G P L +D G ++ L L
Sbjct: 2038 VLEGQEVRLDCEADGQPP---PDVAWLKD---GSP-----LGQDMGPHLRFYLDGGSLVL 2086
Query: 205 VPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVI---VEMNSSVEAIEGSHVSLLC 261
R ++ C A N + +++V PP I + + ++ + G V+++C
Sbjct: 2087 KGLRASDAGAYTCVAH--NPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVC 2144
Query: 262 GADSNPPPLLTWMRDGTVLREAVAESL-----LLELEEVTPAEDGVYACLAENAYGQDNR 316
+PP ++W++DG L + L L + +V A+ G++ C+A + G +R
Sbjct: 2145 PVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADR 2204
Query: 317 TVGLSVMYAPWKPTVN--GTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESE 374
L V P V +V V G V + C + P P+++ K+ + L + E
Sbjct: 2205 NFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQG 2264
Query: 375 LQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAAARDT----VQC 430
L+L AV D G Y CVA ++ G+ F L+V P + T ++
Sbjct: 2265 PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMEL 2324
Query: 431 LCVVKSNPEPSVAFELPSRNVT--VNESEREFVYSERSGLVLTSIL---------TLRGQ 479
LC + P+P++ + + +T N S V R + T + + R +
Sbjct: 2325 LCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVR 2384
Query: 480 AQAPPRVI 487
QAPP ++
Sbjct: 2385 VQAPPNIV 2392
Score = 79.7 bits (195), Expect = 7e-15
Identities = 60/225 (26%), Positives = 96/225 (42%), Gaps = 35/225 (15%)
Query: 255 SHVSLLCGADSNPPPLLTWMRDGTVLR-----EAVAESLLLELEEVTPAEDGVYACLAEN 309
S ++L C + + PPP + W +DG + + + E LL+++ ++ G Y C+A N
Sbjct: 1464 STLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATN 1523
Query: 310 AYGQDNRTVGLSVMYAPWKPTVNGTMVA--------------------VEGETVSILCST 349
G+D++ + + P V A VE + C T
Sbjct: 1524 VAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDT 1583
Query: 350 QSNPDPILTIFKEKQILSTVIYESELQ----LELPAVSPEDDGEYWCVAENQYGQRATAF 405
+ P P LT ++E Q LS S LQ L++P V E+ G Y C A N+ G+ +
Sbjct: 1584 NAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHY 1643
Query: 406 NLSVEFAPVL------LLESHCAAARDTVQCLCVVKSNPEPSVAF 444
L V PV+ L+E A TV C NP P++++
Sbjct: 1644 ELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISW 1688
Score = 77.0 bits (188), Expect = 5e-14
Identities = 94/383 (24%), Positives = 143/383 (37%), Gaps = 51/383 (13%)
Query: 141 PNIVVPPE----VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTW 196
P I +PP V+ T V ++C P P L WL PA L+ G
Sbjct: 786 PRITLPPSLPGPVLVNTPVRLTCNAT-GAPS--PTLMWLKDGNPVSPAGTPGLQVFPGGR 842
Query: 197 VQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSH 256
V L R ++ R C A + + + V PP I+ +V +
Sbjct: 843 V----LTLASARASDSGRYSCVAV--SAVGEDRQDVVLQVHMPPSILGEELNVSVVANES 896
Query: 257 VSLLCGADSNPPPLLTWMRDGTVLR-----EAVAESLLLELEEVTPAEDGVYACLAENAY 311
V+L C + + PPP+L+W +DG L A+ LL+++ + G Y C A N
Sbjct: 897 VALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQA 956
Query: 312 GQDNRTVGLSVMYAPWKP-TVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQIL---- 366
G+ + L+V AP P + T+ EG S+ C + P P ++ K+ Q L
Sbjct: 957 GRSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEG 1016
Query: 367 ---------STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL- 416
++Y + QL +G Y C N G + L V P +
Sbjct: 1017 AGLQHVSAVGRLLYLGQAQL-------AQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAG 1069
Query: 417 ---LESHCAAARDTVQCL-CVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTS 472
+ + +D V L C P P+V +E + V + + G S
Sbjct: 1070 PREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELG----LQLQNQG---QS 1122
Query: 473 ILTLRGQAQAPPRVICTARNLYG 495
+ R QA R C A NL G
Sbjct: 1123 LHVERAQAAHTGRYSCVAENLAG 1145
Score = 75.5 bits (184), Expect = 1e-13
Identities = 86/332 (25%), Positives = 125/332 (37%), Gaps = 38/332 (11%)
Query: 172 LSWLGHE-GLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTL---- 226
L W G+ LG V G DEG LHF + R G QA T
Sbjct: 141 LGWAGYGWDLGWGQVGGHRLLDEG-----QSLHFPRIQPGRSGRRGAQAGGSAQTKAPWX 195
Query: 227 -------QFEGYASMDVKYPPVIVEMNSSVEAI--EGSHVSLLCGADSNPPPLLTWMRD- 276
QF + PP ++ ++ E + G+ V L C P P + W +D
Sbjct: 196 AGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDR 255
Query: 277 -----GTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAP--WKP 329
G + + +L + ++G Y C+A + GQ R L V P W
Sbjct: 256 QPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGS 315
Query: 330 TVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILST---VIY-ESELQLELPAVSPE 385
G + +E V +LC + P P +T FK+ +L T V+Y QL+L
Sbjct: 316 NETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSS 375
Query: 386 DDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESH-----CAAARDTVQCLCVVKSNPEP 440
D G Y C A N G A L V P + A A V CV + +P P
Sbjct: 376 DAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSP 435
Query: 441 SVAFELPSRNVTVNESEREFVYSERSGLVLTS 472
++++ + V ES + ++ S L L S
Sbjct: 436 TLSWH--HEGLPVAESNESRLETDGSVLRLES 465
Score = 72.8 bits (177), Expect = 9e-13
Identities = 63/224 (28%), Positives = 92/224 (41%), Gaps = 20/224 (8%)
Query: 250 EAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-----LELEEVTPAEDGVYA 304
E +E + L C ++ PPP LTW R+ L S+L L++ V G Y+
Sbjct: 1570 EIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYS 1629
Query: 305 CLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVE------GETVSILCSTQSNPDPILT 358
C A N G+D L V+ P + T VE TVS+ C NP P ++
Sbjct: 1630 CKASNEVGEDWLHYELLVLTPP--VILGDTEELVEEVTVNASSTVSLQCPALGNPVPTIS 1687
Query: 359 IFKEKQILS----TVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPV 414
+ S + E L++ D Y CVAENQ G F L V+ P
Sbjct: 1688 WLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPR 1747
Query: 415 LL---LESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNE 455
+ LE A +V C V ++P P V + S+ +++ E
Sbjct: 1748 IAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGE 1791
Score = 72.4 bits (176), Expect = 1e-12
Identities = 63/229 (27%), Positives = 97/229 (42%), Gaps = 26/229 (11%)
Query: 236 VKYPPVIVEMNSS--VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-----VAESL 288
V PP I N + V +E V LLC A P P +TW +DG +L +
Sbjct: 306 VHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGR 365
Query: 289 LLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNG------TMVAVEGET 342
L+L ++ GVY C A NA G + L V Y P PT+ G + AV G
Sbjct: 366 QLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV-YVP--PTIEGAGGRPYVVKAVAGRP 422
Query: 343 VSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGE-----YWCVAENQ 397
V++ C + +P P L+ + + + ES L+ + + E GE Y CVA +
Sbjct: 423 VALECVARGHPSPTLS-WHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSP 481
Query: 398 YGQRATAFNLSVEFAPVLLLESHCAAARDTV----QCLCVVKSNPEPSV 442
G+ +++ V+ P LL+ V + C +P P++
Sbjct: 482 AGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTI 530
Score = 72.4 bits (176), Expect = 1e-12
Identities = 95/381 (24%), Positives = 143/381 (37%), Gaps = 53/381 (13%)
Query: 134 VLDIVNTPNIVVPPEVVAGTEVEVSCM---VPDNCPELRPELSWLGHEGLGEPAVLGRLR 190
VL+ V N VV VV G+ VE+ C VP P +SW+ GEP + L
Sbjct: 2215 VLEPVEFQNDVV---VVRGSLVELPCEARGVP------LPLVSWMKD---GEPLLSQSLE 2262
Query: 191 EDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYA----SMDVKYPPVIVEMN 246
+ P+ + G ++ + G A + V PP I +
Sbjct: 2263 QG-------------PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSG 2309
Query: 247 SSVEA--IEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDGVYA 304
E G+ + LLC A P P +TW +DG L S + V A G+Y
Sbjct: 2310 QPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDA--GLYT 2367
Query: 305 CLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAV---EGETVSILCSTQSNPDPILTIFK 361
CLAE+ G ++ + V P G V G+ V + CS ++ P P +T +
Sbjct: 2368 CLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLV-LECSVEAEPAPKITWHR 2426
Query: 362 EKQILS----TVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLL 417
+ +L T E L+L A+S D G+Y C A N G + AF + + P +
Sbjct: 2427 DGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRS 2486
Query: 418 ESHC--AAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILT 475
+ T C P P V++ V ++ F L + +L
Sbjct: 2487 GPPAVNVSVNQTALLPCQADGVPAPLVSWR--KDRVPLDPRSPRFEILPEGSLRIQPVL- 2543
Query: 476 LRGQAQAPPRVICTARNLYGA 496
AQ +C A N G+
Sbjct: 2544 ----AQDAGHYLCLASNSAGS 2560
Score = 69.7 bits (169), Expect = 8e-12
Identities = 50/200 (25%), Positives = 86/200 (43%), Gaps = 20/200 (10%)
Query: 233 SMDVKYPPVIVEMNS-SVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-- 289
++ V+ PP + +V + GS + L C P P +TW++D + + ++
Sbjct: 1926 TLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSR 1985
Query: 290 ---LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVA-----VEGE 341
L+L + PA+ G Y C+AEN + + ++V+ A P + + VA +EG+
Sbjct: 1986 GGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVA---PRIRSSGVAREHHVLEGQ 2042
Query: 342 TVSILCSTQSNPDPILTIFKEKQILSTVI------YESELQLELPAVSPEDDGEYWCVAE 395
V + C P P + K+ L + Y L L + D G Y CVA
Sbjct: 2043 EVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAH 2102
Query: 396 NQYGQRATAFNLSVEFAPVL 415
N G+ A ++V P +
Sbjct: 2103 NPAGEDARLHTVNVLVPPTI 2122
Score = 65.9 bits (159), Expect = 1e-10
Identities = 64/291 (21%), Positives = 117/291 (40%), Gaps = 27/291 (9%)
Query: 141 PNIVVP--PEVVAGT---EVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGT 195
PNIV P P V G ++ + C V E P+++W +G+ + G
Sbjct: 2389 PNIVGPRGPRFVVGLAPGQLVLECSVE---AEPAPKITW-HRDGIVLQEDAHTQFPERGR 2444
Query: 196 WVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGS 255
++Q+ L T ++ + + + +T++ F +++ P I +V
Sbjct: 2445 FLQLQALS---TADSGDYSCTARNAAGSTSVAFR----VEIHTVPTIRSGPPAVNVSVNQ 2497
Query: 256 HVSLLCGADSNPPPLLTWMRDGTVL-----REAVAESLLLELEEVTPAEDGVYACLAENA 310
L C AD P PL++W +D L R + L ++ V + G Y CLA N+
Sbjct: 2498 TALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNS 2557
Query: 311 YGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVI 370
G D + L V+ P + + C +P P++ +K+ Q L +
Sbjct: 2558 AGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRL 2617
Query: 371 YESELQ------LELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL 415
+ + L L A P+D ++ CV N+ G+ + ++V P +
Sbjct: 2618 QQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTI 2668
Score = 65.9 bits (159), Expect = 1e-10
Identities = 53/201 (26%), Positives = 84/201 (41%), Gaps = 15/201 (7%)
Query: 254 GSHVSLLCGADSNPPPLLTWMRDGTVLREAVAES---LLLELEEVTPAEDGVYACLAENA 310
G + L C A +P P + W + + E V+E L+ V+ + G Y C AEN
Sbjct: 2952 GDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENR 3011
Query: 311 YGQDNRTVGLSVMYAPWKPTVNGT----MVAVEGETVSILCSTQSNPDPILTIFKEKQIL 366
G RT +S ++ P + G +V G ++ + C + +P P + K+ L
Sbjct: 3012 VG---RTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPL 3068
Query: 367 STVIYESELQ---LELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAA 423
+LQ L + +D G Y C+AEN+ G L ++ APV +E
Sbjct: 3069 RGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMT 3128
Query: 424 AR--DTVQCLCVVKSNPEPSV 442
R D V C P P++
Sbjct: 3129 VRSGDDVALRCQATGEPTPTI 3149
Score = 65.1 bits (157), Expect = 2e-10
Identities = 80/322 (24%), Positives = 123/322 (38%), Gaps = 43/322 (13%)
Query: 150 VAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVS----LLHFV 205
+ G +E+ C + P + WL + G PA +E VQV+ LH
Sbjct: 511 IVGQPLELPCQASGSPV---PTIQWLQN---GRPA-------EELAGVQVASQGTTLHID 557
Query: 206 PTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEM-----------NSSVEAIEG 254
+ CQA+ T E S+ ++ P ++E+ +SS A
Sbjct: 558 HVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACD 617
Query: 255 SHVSLLCGADSNPPPLLTWMRDGTVLREA----VAESLL--LELEEVTPAEDGVYACLAE 308
V GA PP + W G++ E VA SL L++E+V ++G+Y C A
Sbjct: 618 PPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAAT 677
Query: 309 NAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILS- 367
N G+ R V L V+ P +E +V++ C P P ++ FK Q +S
Sbjct: 678 NLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSS 737
Query: 368 ----TVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHC-- 421
TV + + L + D G Y CVA N G + L V P + L
Sbjct: 738 WMGVTVSVDGRV-LRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPG 796
Query: 422 -AAARDTVQCLCVVKSNPEPSV 442
V+ C P P++
Sbjct: 797 PVLVNTPVRLTCNATGAPSPTL 818
Score = 59.3 bits (142), Expect = 1e-08
Identities = 81/332 (24%), Positives = 128/332 (38%), Gaps = 54/332 (16%)
Query: 148 EVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPT 207
+ VAG V + C+ + P LSW HEGL E +G S+L
Sbjct: 416 KAVAGRPVALECVARGHPS---PTLSW-HHEGLPVAESNESRLETDG-----SVLRLESP 466
Query: 208 REANGHRLGCQASFP--NTTLQFEGYASMDVKYPP--VIVEMNSSVEAIEGSHVSLLCGA 263
EA+ C AS P LQ+ S++V+ PP ++ E V I G + L C A
Sbjct: 467 GEASSGLYSCVASSPAGEAVLQY----SVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQA 522
Query: 264 DSNPPPLLTWMRDGTVLRE-----AVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTV 318
+P P + W+++G E ++ L ++ V G++AC A N G V
Sbjct: 523 SGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEV 582
Query: 319 GLSVMYAPWKPTVNGTMVA------VEGETVSILCSTQ------SNPDPIL--------T 358
+SV + W P V + + C ++P P L +
Sbjct: 583 EVSV-HGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGS 641
Query: 359 IFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQ--RATAFNL----SVEFA 412
++ E + V Y L++ V D+G Y C A N G+ R A + ++E
Sbjct: 642 LWGEPTGI-PVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPG 700
Query: 413 PVLLLESHCAAARDTVQCLCVVKSNPEPSVAF 444
PV + +V C+ P P V++
Sbjct: 701 PV----NKAVLENASVTLECLASGVPPPDVSW 728
Score = 58.2 bits (139), Expect = 2e-08
Identities = 68/255 (26%), Positives = 102/255 (40%), Gaps = 24/255 (9%)
Query: 170 PELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFE 229
P + W ++ P G +D G+ +Q + + +RE +G + C A N + +
Sbjct: 2967 PRIGWTVND---RPVTEGVSEQDGGSTLQRAAV----SREDSGTYV-CWAE--NRVGRTQ 3016
Query: 230 GYASMDVKYPPVIVEMNSS--VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAES 287
+ + VK PV+ S VE + GS + L C +P P + W++DG LR +
Sbjct: 3017 AVSFVHVKEAPVLQGEAFSYLVEPVGGS-IQLDCVVRGDPVPDIHWIKDGLPLRGSHLRH 3075
Query: 288 LL----LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETV 343
L L + + G Y CLAEN G + V L + AP M G+ V
Sbjct: 3076 QLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDV 3135
Query: 344 SILCSTQSNPDPILTIFKEKQILST-----VIYESELQLELPAVSPEDDGEYWCVAENQY 398
++ C P P + + Q L + + L LE V D G Y CVA N
Sbjct: 3136 ALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLE--NVETGDAGTYDCVAHNLL 3193
Query: 399 GQRATAFNLSVEFAP 413
G L V P
Sbjct: 3194 GSATARAFLVVRGEP 3208
Score = 52.8 bits (125), Expect = 1e-06
Identities = 54/231 (23%), Positives = 83/231 (35%), Gaps = 13/231 (5%)
Query: 239 PPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAE-------SLLLE 291
PP I S++ + L C A +P PL+ W +DG L + + S L
Sbjct: 2572 PPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALL 2631
Query: 292 LEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQS 351
L P + + C+ N G+ +R ++V P V + C +
Sbjct: 2632 LTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTG 2691
Query: 352 NPDPILTIFKEKQIL----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNL 407
P P ++ K L S LE+ P G Y C A N G L
Sbjct: 2692 IPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFL 2751
Query: 408 SVEFAPVL--LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNES 456
+V+ +PV+ L A A + V C P P++ ++ NV S
Sbjct: 2752 TVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVS 2802
Score = 48.1 bits (113), Expect = 2e-05
Identities = 65/280 (23%), Positives = 100/280 (35%), Gaps = 60/280 (21%)
Query: 217 CQASFPNTTLQFEGYASMDVKYPPVIVE--MNSSVEAIEGSHVSLLCGADSNPPPLLTWM 274
CQA+ N A + V PP I E ++V + G ++L C A+ P P + W+
Sbjct: 74 CQAT--NEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWL 131
Query: 275 RDGTVL--------------------REAVAESLLLELEEVTPAEDGVYACLA-ENAYGQ 313
+D ++ + E L + P G A +A +
Sbjct: 132 KDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTK 191
Query: 314 DNRTVGLS---------VMYAPWKPTVNGTMVAVE-----GETVSILCSTQSNPDPILTI 359
GL+ P P+V G A E G V + C T P P +
Sbjct: 192 APWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEW 251
Query: 360 FKEKQIL-----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAP- 413
K++Q + + E L + D+G Y CVA + GQ+A F L V P
Sbjct: 252 TKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPT 311
Query: 414 ---------VLLLESHCAAARDTVQCLCVVKSNPEPSVAF 444
V ++E H VQ LC + P P++ +
Sbjct: 312 IWGSNETGEVAVMEDH------LVQLLCEARGVPTPNITW 345
Score = 45.4 bits (106), Expect = 2e-04
Identities = 35/116 (30%), Positives = 50/116 (43%), Gaps = 12/116 (10%)
Query: 261 CGADSNPPPLLTWMRDGTVLRE-------AVAESLLLELEEVTPAEDGVYACLAENAYGQ 313
CG P P +TW R G AV E L L V+PA+ G Y C A N G
Sbjct: 24 CGTHGTPKPQVTW-RKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGS 82
Query: 314 DNRTVGLSVMYAPWKPTVNGTMVAVE---GETVSILCSTQSNPDPILTIFKEKQIL 366
+R L V+Y P +G V G+++++ C P P + K+ Q++
Sbjct: 83 TSRRAKL-VVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLV 137
Score = 30.8 bits (68), Expect = 3.9
Identities = 23/72 (31%), Positives = 28/72 (38%), Gaps = 5/72 (6%)
Query: 347 CSTQSNPDPILTIFKEKQILST-----VIYESELQLELPAVSPEDDGEYWCVAENQYGQR 401
C T P P +T K V E L L +VSP D G+Y C A N+ G
Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGST 83
Query: 402 ATAFNLSVEFAP 413
+ L V P
Sbjct: 84 SRRAKLVVYVPP 95
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 95.9 bits (237), Expect = 1e-19
Identities = 93/353 (26%), Positives = 155/353 (43%), Gaps = 33/353 (9%)
Query: 131 EHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLR 190
+H L + +P + P VV E + + RP ++W EGL +
Sbjct: 3938 KHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQ-KEGLNVATGVSTQV 3996
Query: 191 EDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVE 250
G Q+ + H P E G+ L C A N+ G + V+ PPVI +
Sbjct: 3997 LPGG---QLRIAHASP--EDAGNYL-CIAK--NSAGSAMGKTRLVVQVPPVIENGLPDLS 4048
Query: 251 AIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-----VAESLLLELEEVTPAEDGVYAC 305
EGSH L C A +P P +TW +DG + A + S L ++ + + G Y C
Sbjct: 4049 TTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTC 4108
Query: 306 LAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQI 365
AENA G+ R V L+++ P T+ G G+ + + C+ + +P P + +
Sbjct: 4109 TAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRP 4168
Query: 366 LSTVIYESE--LQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAA 423
++ + E + L+ AVS ED G Y C AEN+ G+ + V+ APVL E+
Sbjct: 4169 VTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYL 4228
Query: 424 AR---DTVQCLCVVKSNPEPSVAF--------------ELPSRNVTVNESERE 459
++Q CVV+ +P P + + +L + ++T++ +ER+
Sbjct: 4229 VEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERD 4281
Score = 92.0 bits (227), Expect = 1e-18
Identities = 93/329 (28%), Positives = 138/329 (41%), Gaps = 35/329 (10%)
Query: 143 IVVPPEVVAGTE-------VEVSCMVPDNCPELR---PELSWLGHEGLGEPAVLGRLRED 192
++ PP ++ TE V S V CP L P +SWL + P+ ++ ED
Sbjct: 2838 VLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLED 2897
Query: 193 EGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMN-SSVEA 251
G +QVS A+ C A N E ++ V+ PP I ++ V A
Sbjct: 2898 -GQVLQVSTAEV-----ADAASYMCVAE--NQAGSAEKLFTLRVQVPPRIAGLDLEQVTA 2949
Query: 252 IEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-----LELEEVTPAEDGVYACL 306
I S VSL C ++P P +TW +D L LL L+L ++ G+Y C
Sbjct: 2950 ILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCE 3009
Query: 307 AENAYGQDNRTVGLSVMYAP-WKPTVNGTMVAV---EGETVSILCSTQSNPDPILTIFKE 362
A NA G+D + V LSV+ P ++ G AV G+ + C T + P+P +T +K+
Sbjct: 3010 ALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKD 3069
Query: 363 KQIL----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL--- 415
Q L T +LE+ D G Y C N G+ F L+V+ P
Sbjct: 3070 GQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENP 3129
Query: 416 LLESHCAAARDTVQCLCVVKSNPEPSVAF 444
E+ A + C V P P+V +
Sbjct: 3130 KTETVSQVAGSPLVLTCDVSGVPAPTVTW 3158
Score = 87.8 bits (216), Expect = 3e-17
Identities = 93/374 (24%), Positives = 151/374 (40%), Gaps = 29/374 (7%)
Query: 137 IVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTW 196
+V PN+ V P G +SC V P L+W+ + PA GR+ +
Sbjct: 520 LVPAPNVTVSP----GETAVLSCRVLGEAPY---NLTWV-RDWRVLPASTGRVAQLADLS 571
Query: 197 VQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSH 256
+++S + +PT +G R C AS N + + + V+ P + SS +G
Sbjct: 572 LEISGI--IPT---DGGRYQCVASNANGVTRASVW--LLVREAPQVSIHTSSQHFSQGVE 624
Query: 257 VSLLCGADSNPPPLLTWMRDGTVLREA----VAESLLLELEEVTPAEDGVYACLAENAYG 312
V + C A P P ++W R+ L+E V L ++ V P + G Y+C A N G
Sbjct: 625 VKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVG 684
Query: 313 QDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFK-EKQILSTVIY 371
D TV L P VN ++ GE ++C P P + ++ +++
Sbjct: 685 TDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEG 744
Query: 372 ESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL--LLESHCAAARDTVQ 429
S +L +PA D G Y C A N+ G + L+V AP L L +
Sbjct: 745 SSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSAL 804
Query: 430 CLCVVKSNPEPSVAF---ELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQAQAPPRV 486
C P P+V + + + + SG++ ++ + QAP
Sbjct: 805 LACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFE--SVAPEDQAP--Y 860
Query: 487 ICTARNLYGAKSLE 500
+C ARN++G E
Sbjct: 861 VCEARNVFGKVQAE 874
Score = 83.2 bits (204), Expect = 7e-16
Identities = 70/270 (25%), Positives = 112/270 (41%), Gaps = 17/270 (6%)
Query: 236 VKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-----VAESLLL 290
V PP I + + + V L C + P P ++W + G L V+ S L
Sbjct: 3853 VHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGAL 3912
Query: 291 ELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQ 350
E+ + P G Y C A N+ G ++ V L+V +P + + AV E V + C
Sbjct: 3913 EIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEAS 3972
Query: 351 SNPDPILTIFKEKQILSTVIYESEL---QLELPAVSPEDDGEYWCVAENQYGQRATAFNL 407
P P +T KE ++T + L QL + SPED G Y C+A+N G L
Sbjct: 3973 GIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRL 4032
Query: 408 SVEFAPVLL--LESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSER 465
V+ PV+ L C + +PEP++ ++ + V+ +E +F
Sbjct: 4033 VVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQ--PVSGAEGKFTIQPS 4090
Query: 466 SGLVLTSILTLRGQAQAPPRVICTARNLYG 495
L++ ++ + Q CTA N G
Sbjct: 4091 GELLVKNL-----EGQDAGTYTCTAENAVG 4115
Score = 81.6 bits (200), Expect = 2e-15
Identities = 93/419 (22%), Positives = 163/419 (38%), Gaps = 51/419 (12%)
Query: 142 NIVVPPEVVAGTEVEVSCMVPDNCPELR---------PELSWLGHEGLGEPAVLGRLRED 192
+++VPPE++ + + + P P + W E EP G ED
Sbjct: 2345 SVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGE---EPVSPG---ED 2398
Query: 193 EGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIV--EMNSSVE 250
+L T+E + C AS N + S++V PP I ++ ++
Sbjct: 2399 TYLLAGGWMLKMTQTQEQDSGLYSCLAS--NEAGEARRNFSVEVLVPPSIENEDLEEVIK 2456
Query: 251 AIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVA-----ESLLLELEEVTPAEDGVYAC 305
++G L+C +P P LTW +DG L A + +LL++ + + G Y+C
Sbjct: 2457 VLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSC 2516
Query: 306 LAENAYGQDNRTVGLSVMYAPW-----KPTVNGTMVAVEGETVSILCSTQSNPDPILTIF 360
+A NA G+ + LSV+ AP + + + + +S++C + P P +T
Sbjct: 2517 IAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWM 2576
Query: 361 KE----KQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL 416
K+ + + + L++ ED G+Y CV N+ G+ +++ V P +
Sbjct: 2577 KDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSIS 2636
Query: 417 LESHC---------AAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSG 467
+ T+ C + P P++ + + VT S R V E
Sbjct: 2637 KDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVT--PSSRLQVLGEGRL 2694
Query: 468 LVLTSILTLRGQAQAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAIL 526
L + Q R +C A N+ G + M+ K+G A AF IL
Sbjct: 2695 LQIQPT-----QVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSA--AFEIL 2746
Score = 80.9 bits (198), Expect = 3e-15
Identities = 70/286 (24%), Positives = 117/286 (40%), Gaps = 30/286 (10%)
Query: 234 MDVKYPPVIV---EMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL- 289
++V PP I E + V ++ +L C A PPP +TW RDG + + L
Sbjct: 2250 LEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQN 2309
Query: 290 ----LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAP-----WKPTVNGTMVAVEG 340
L +E A G Y+C+AEN G+ R LSV+ P P N + A
Sbjct: 2310 QGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTN--ITAALH 2367
Query: 341 ETVSILCSTQSNPDPILTIFKEKQILS----TVIYESELQLELPAVSPEDDGEYWCVAEN 396
+++LC P P + F+ ++ +S T + L++ +D G Y C+A N
Sbjct: 2368 SPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASN 2427
Query: 397 QYGQRATAFNLSVEFAPVL----LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVT 452
+ G+ F++ V P + L E T +C V +P+P + + R +
Sbjct: 2428 EAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLA 2487
Query: 453 VNESEREFVYSERSGLVLTSILTLRGQAQAPPRVICTARNLYGAKS 498
++ + G++L L+ + C A N G K+
Sbjct: 2488 RGDAH----HISPDGVLLQ---VLQANLSSAGHYSCIAANAVGEKT 2526
Score = 80.1 bits (196), Expect = 6e-15
Identities = 87/368 (23%), Positives = 153/368 (41%), Gaps = 42/368 (11%)
Query: 149 VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSL----LHF 204
V+ G EV + C P P+++WL G P L +D G ++ L L
Sbjct: 3229 VLEGQEVRLDCEADGQPP---PDVAWLKD---GSP-----LGQDMGPHLRFYLDGGSLVL 3277
Query: 205 VPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVI---VEMNSSVEAIEGSHVSLLC 261
R ++ C A N + +++V PP I + + ++ + G V+++C
Sbjct: 3278 KGLRASDAGAYTCVAH--NPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVC 3335
Query: 262 GADSNPPPLLTWMRDGTVLREAVAESL-----LLELEEVTPAEDGVYACLAENAYGQDNR 316
+PP ++W++DG L + L L + +V A+ G++ C+A + G +R
Sbjct: 3336 PVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADR 3395
Query: 317 TVGLSVMYAPWKPTVN--GTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESE 374
L V P V +V V G V + C + P P+++ K+ + L + E
Sbjct: 3396 NFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQG 3455
Query: 375 LQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAAARDT----VQC 430
L+L AV D G Y CVA ++ G+ F L+V P + T ++
Sbjct: 3456 PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMEL 3515
Query: 431 LCVVKSNPEPSVAFELPSRNVT--VNESEREFVYSERSGLVLTSIL---------TLRGQ 479
LC + P+P++ + + +T N S V R + T + + R +
Sbjct: 3516 LCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVR 3575
Query: 480 AQAPPRVI 487
QAPP ++
Sbjct: 3576 VQAPPNIV 3583
Score = 79.7 bits (195), Expect = 7e-15
Identities = 60/225 (26%), Positives = 96/225 (42%), Gaps = 35/225 (15%)
Query: 255 SHVSLLCGADSNPPPLLTWMRDGTVLR-----EAVAESLLLELEEVTPAEDGVYACLAEN 309
S ++L C + + PPP + W +DG + + + E LL+++ ++ G Y C+A N
Sbjct: 2655 STLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATN 2714
Query: 310 AYGQDNRTVGLSVMYAPWKPTVNGTMVA--------------------VEGETVSILCST 349
G+D++ + + P V A VE + C T
Sbjct: 2715 VAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDT 2774
Query: 350 QSNPDPILTIFKEKQILSTVIYESELQ----LELPAVSPEDDGEYWCVAENQYGQRATAF 405
+ P P LT ++E Q LS S LQ L++P V E+ G Y C A N+ G+ +
Sbjct: 2775 NAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHY 2834
Query: 406 NLSVEFAPVL------LLESHCAAARDTVQCLCVVKSNPEPSVAF 444
L V PV+ L+E A TV C NP P++++
Sbjct: 2835 ELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISW 2879
Score = 78.2 bits (191), Expect = 2e-14
Identities = 91/351 (25%), Positives = 138/351 (39%), Gaps = 57/351 (16%)
Query: 130 SEHSVLDIVNTPNIVVPP---EVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVL 186
S VL + P + P +V+ G ++++C+ N PE P+LSW + V+
Sbjct: 1109 SHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGN-PE--PQLSW------SKDGVV 1159
Query: 187 GRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPV--IVE 244
+ R +G+ +HF R ++ R C+AS +E + V PP E
Sbjct: 1160 LQGRGPQGS------VHFAAIRTSDAGRYRCEASNSAGVDAWE--VELRVLEPPHWGADE 1211
Query: 245 MNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLRE-------AVAESLLLELEEVTP 297
+ +E + G + SL C A P P +TW R G AV E L L V+P
Sbjct: 1212 TSGLLERVAGENASLPCPARGTPKPQVTW-RKGPSSEPLHGQPGVAVLEEGSLFLASVSP 1270
Query: 298 AEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEG---ETVSILCSTQSNPD 354
A+ G Y C A N G +R L V+Y P +G V G +++++ C P
Sbjct: 1271 ADSGDYECQATNEVGSTSRRAKL-VVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPV 1329
Query: 355 PILTIFKEKQILSTVI-------------------YESELQLELPAVSPEDDGEYWCVAE 395
P + K+ Q++ + + L P + D G Y C AE
Sbjct: 1330 PEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAE 1389
Query: 396 NQYGQRATAFNLSVEFAPVLL----LESHCAAARDTVQCLCVVKSNPEPSV 442
NQ G F+L V P +L + A V+ C P P V
Sbjct: 1390 NQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQV 1440
Score = 76.6 bits (187), Expect = 6e-14
Identities = 94/383 (24%), Positives = 142/383 (37%), Gaps = 51/383 (13%)
Query: 141 PNIVVPPE----VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTW 196
P I +PP V+ T V ++C P P L WL PA L+ G
Sbjct: 1977 PRITLPPSLPGPVLVNTPVRLTCNAT-GAPS--PTLMWLKDGNPVSPAGTPGLQVFPGGR 2033
Query: 197 VQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSH 256
V L R ++ R C A + + + V PP I+ +V +
Sbjct: 2034 V----LTLASARASDSGRYSCVAV--SAVGEDRQDVVLQVHMPPSILGEELNVSVVANES 2087
Query: 257 VSLLCGADSNPPPLLTWMRDGTVLR-----EAVAESLLLELEEVTPAEDGVYACLAENAY 311
V+L C + + PPP+L+W +DG L A+ LL+++ + G Y C A N
Sbjct: 2088 VALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQA 2147
Query: 312 GQDNRTVGLSVMYAPWKP-TVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQIL---- 366
G + L+V AP P + T+ EG S+ C + P P ++ K+ Q L
Sbjct: 2148 GHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEG 2207
Query: 367 ---------STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL- 416
++Y + QL +G Y C N G + L V P +
Sbjct: 2208 AGLQHVSAVGRLLYLGQAQL-------AQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAG 2260
Query: 417 ---LESHCAAARDTVQCL-CVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTS 472
+ + +D V L C P P+V +E + V + + G S
Sbjct: 2261 PREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELG----LQLQNQG---QS 2313
Query: 473 ILTLRGQAQAPPRVICTARNLYG 495
+ R QA R C A NL G
Sbjct: 2314 LHVERAQAAHTGRYSCVAENLAG 2336
Score = 74.3 bits (181), Expect = 3e-13
Identities = 55/176 (31%), Positives = 77/176 (43%), Gaps = 8/176 (4%)
Query: 232 ASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVL-----REAVAE 286
A + V PP + +V G L C P LTW+RD VL R A
Sbjct: 509 AQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLA 568
Query: 287 SLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSIL 346
L LE+ + P + G Y C+A NA G +V L V AP + +G V +
Sbjct: 569 DLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVS 628
Query: 347 CSTQSNPDPILTIFKEKQIL---STVIYESELQLELPAVSPEDDGEYWCVAENQYG 399
CS P P ++ +E Q L S + +++ L + V+PED G Y C A N+ G
Sbjct: 629 CSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVG 684
Score = 73.9 bits (180), Expect = 4e-13
Identities = 67/239 (28%), Positives = 100/239 (41%), Gaps = 13/239 (5%)
Query: 186 LGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYAS----MDVKYPPV 241
+ RL + W + LL R A ++G + T G AS + V+ PP
Sbjct: 1063 VNRLALSKYVWEEYGLLPSGSLRLAQV-QVGDSGHYECTASNPAGSASHRYVLGVQVPPQ 1121
Query: 242 IVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDG 301
+ ++ + G + L C A+ NP P L+W +DG VL+ + + + ++ G
Sbjct: 1122 VQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQGRGPQG-SVHFAAIRTSDAG 1180
Query: 302 VYACLAENAYGQDNRTVGLSVMYAP-W-KPTVNGTMVAVEGETVSILCSTQSNPDPILTI 359
Y C A N+ G D V L V+ P W +G + V GE S+ C + P P +T
Sbjct: 1181 RYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTW 1240
Query: 360 FKEKQI-----LSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAP 413
K V E L L +VSP D G+Y C A N+ G + L V P
Sbjct: 1241 RKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPP 1299
Score = 72.8 bits (177), Expect = 9e-13
Identities = 63/224 (28%), Positives = 92/224 (41%), Gaps = 20/224 (8%)
Query: 250 EAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-----LELEEVTPAEDGVYA 304
E +E + L C ++ PPP LTW R+ L S+L L++ V G Y+
Sbjct: 2761 EIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYS 2820
Query: 305 CLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVE------GETVSILCSTQSNPDPILT 358
C A N G+D L V+ P + T VE TVS+ C NP P ++
Sbjct: 2821 CKASNEVGEDWLHYELLVLTPP--VILGDTEELVEEVTVNASSTVSLQCPALGNPVPTIS 2878
Query: 359 IFKEKQILS----TVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPV 414
+ S + E L++ D Y CVAENQ G F L V+ P
Sbjct: 2879 WLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPR 2938
Query: 415 LL---LESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNE 455
+ LE A +V C V ++P P V + S+ +++ E
Sbjct: 2939 IAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGE 2982
Score = 72.4 bits (176), Expect = 1e-12
Identities = 63/229 (27%), Positives = 97/229 (42%), Gaps = 26/229 (11%)
Query: 236 VKYPPVIVEMNSS--VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-----VAESL 288
V PP I N + V +E V LLC A P P +TW +DG +L +
Sbjct: 1497 VHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGR 1556
Query: 289 LLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNG------TMVAVEGET 342
L+L ++ GVY C A NA G + L V Y P PT+ G + AV G
Sbjct: 1557 QLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV-YVP--PTIEGAGGRPYVVKAVAGRP 1613
Query: 343 VSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGE-----YWCVAENQ 397
V++ C + +P P L+ + + + ES L+ + + E GE Y CVA +
Sbjct: 1614 VALECVARGHPSPTLS-WHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSP 1672
Query: 398 YGQRATAFNLSVEFAPVLLLESHCAAARDTV----QCLCVVKSNPEPSV 442
G+ +++ V+ P LL+ V + C +P P++
Sbjct: 1673 AGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTI 1721
Score = 72.4 bits (176), Expect = 1e-12
Identities = 95/381 (24%), Positives = 143/381 (37%), Gaps = 53/381 (13%)
Query: 134 VLDIVNTPNIVVPPEVVAGTEVEVSCM---VPDNCPELRPELSWLGHEGLGEPAVLGRLR 190
VL+ V N VV VV G+ VE+ C VP P +SW+ GEP + L
Sbjct: 3406 VLEPVEFQNDVV---VVRGSLVELPCEARGVP------LPLVSWMKD---GEPLLSQSLE 3453
Query: 191 EDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYA----SMDVKYPPVIVEMN 246
+ P+ + G ++ + G A + V PP I +
Sbjct: 3454 QG-------------PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSG 3500
Query: 247 SSVEA--IEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDGVYA 304
E G+ + LLC A P P +TW +DG L S + V A G+Y
Sbjct: 3501 QPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDA--GLYT 3558
Query: 305 CLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAV---EGETVSILCSTQSNPDPILTIFK 361
CLAE+ G ++ + V P G V G+ V + CS ++ P P +T +
Sbjct: 3559 CLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLV-LECSVEAEPAPKITWHR 3617
Query: 362 EKQILS----TVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLL 417
+ +L T E L+L A+S D G+Y C A N G + AF + + P +
Sbjct: 3618 DGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRS 3677
Query: 418 ESHC--AAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILT 475
+ T C P P V++ V ++ F L + +L
Sbjct: 3678 GPPAVNVSVNQTALLPCQADGVPAPLVSWR--KDRVPLDPRSPRFEILPEGSLRIQPVL- 3734
Query: 476 LRGQAQAPPRVICTARNLYGA 496
AQ +C A N G+
Sbjct: 3735 ----AQDAGHYLCLASNSAGS 3751
Score = 69.7 bits (169), Expect = 8e-12
Identities = 50/200 (25%), Positives = 86/200 (43%), Gaps = 20/200 (10%)
Query: 233 SMDVKYPPVIVEMNS-SVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-- 289
++ V+ PP + +V + GS + L C P P +TW++D + + ++
Sbjct: 3117 TLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSR 3176
Query: 290 ---LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVA-----VEGE 341
L+L + PA+ G Y C+AEN + + ++V+ A P + + VA +EG+
Sbjct: 3177 GGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVA---PRIRSSGVAREHHVLEGQ 3233
Query: 342 TVSILCSTQSNPDPILTIFKEKQILSTVI------YESELQLELPAVSPEDDGEYWCVAE 395
V + C P P + K+ L + Y L L + D G Y CVA
Sbjct: 3234 EVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAH 3293
Query: 396 NQYGQRATAFNLSVEFAPVL 415
N G+ A ++V P +
Sbjct: 3294 NPAGEDARLHTVNVLVPPTI 3313
Score = 67.4 bits (163), Expect = 4e-11
Identities = 71/272 (26%), Positives = 100/272 (36%), Gaps = 16/272 (5%)
Query: 149 VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTR 208
V G ++C P P ++W +G LG R +L F
Sbjct: 797 VELGRSALLACRATGRPP---PTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVA 853
Query: 209 EANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPP 268
+ C+A +Q E + PP I +V +EG VSL C + P
Sbjct: 854 PEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRP 913
Query: 269 -PLLTWMRDGTVL----REAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVM 323
P W++DG L R ++ L L+ G Y+C+A N G +R V L V
Sbjct: 914 LPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQ 973
Query: 324 YAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILST------VIYESELQL 377
P + EG S+ C P P +T KE L++ V E L +
Sbjct: 974 VPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLI 1033
Query: 378 ELPAVSPEDDGEYWCVAENQYGQRATAFNLSV 409
P S +D G Y C A N G + LSV
Sbjct: 1034 AQP--SAQDAGAYVCTATNTVGFSSQEMRLSV 1063
Score = 66.6 bits (161), Expect = 6e-11
Identities = 68/270 (25%), Positives = 104/270 (38%), Gaps = 53/270 (19%)
Query: 217 CQASFPNTTLQFEGYASMDVKYPPVIVE--MNSSVEAIEGSHVSLLCGADSNPPPLLTWM 274
CQA+ N A + V PP I E ++V + G ++L C A+ P P + W+
Sbjct: 1278 CQAT--NEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWL 1335
Query: 275 RDGTVL--------------------REAVAESLLLELEEVTPAEDGVYACLAENAYGQD 314
+D ++ + E L + + G+Y+C AEN G
Sbjct: 1336 KDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTA 1395
Query: 315 NRTVGLSVMYAPWKPTVNGTMVAVE-----GETVSILCSTQSNPDPILTIFKEKQIL--- 366
R L V+ P +V G A E G V + C T P P + K++Q +
Sbjct: 1396 QRDFHLLVLTPP---SVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPG 1452
Query: 367 --STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAP----------V 414
+ E L + D+G Y CVA + GQ+A F L V P V
Sbjct: 1453 GPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEV 1512
Query: 415 LLLESHCAAARDTVQCLCVVKSNPEPSVAF 444
++E H VQ LC + P P++ +
Sbjct: 1513 AVMEDH------LVQLLCEARGVPTPNITW 1536
Score = 65.9 bits (159), Expect = 1e-10
Identities = 103/422 (24%), Positives = 154/422 (36%), Gaps = 44/422 (10%)
Query: 101 TLLLSNVSPELGGKYYFRG--DLGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVS 158
TL++ V+PE G Y + ++G + ++ V+ N VV V G E +
Sbjct: 661 TLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVL--VAVGEEAVLV 718
Query: 159 CMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQ 218
C P P + W + G G +L G L +E + C+
Sbjct: 719 CEASGVPP---PRVIW--YRG-GLEMILAPEGSSSGK------LRIPAAQERDAGTYTCR 766
Query: 219 ASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMR-DG 277
A N + V + P + E+ V G L C A PPP +TW R DG
Sbjct: 767 AV--NELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDG 824
Query: 278 TVL----------REAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVM-YAP 326
L R +S +L E V P + Y C A N +G+ L V +AP
Sbjct: 825 QPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAP 884
Query: 327 WKPTVNGTMVAV-EGETVSILCSTQSN-PDPILTIFKEKQIL---STVIYESELQLELPA 381
+ + V V EG+ VS+ C + P P K+ + L S ++ L L
Sbjct: 885 PQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDR 944
Query: 382 VSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL--LLESHCAAARDTVQCLCVVKSNPE 439
E G Y CVA N G + L V+ P + H CV P
Sbjct: 945 ALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPA 1004
Query: 440 PSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQAQAPPRVICTARNLYGAKSL 499
P++ + + +T S + G ++L + AQ +CTA N G S
Sbjct: 1005 PTITWTKETNALT---SRGPHYNVSKEG----TLLIAQPSAQDAGAYVCTATNTVGFSSQ 1057
Query: 500 EL 501
E+
Sbjct: 1058 EM 1059
Score = 65.9 bits (159), Expect = 1e-10
Identities = 64/291 (21%), Positives = 117/291 (40%), Gaps = 27/291 (9%)
Query: 141 PNIVVP--PEVVAGT---EVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGT 195
PNIV P P V G ++ + C V E P+++W +G+ + G
Sbjct: 3580 PNIVGPRGPRFVVGLAPGQLVLECSVE---AEPAPKITW-HRDGIVLQEDAHTQFPERGR 3635
Query: 196 WVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGS 255
++Q+ L T ++ + + + +T++ F +++ P I +V
Sbjct: 3636 FLQLQALS---TADSGDYSCTARNAAGSTSVAFR----VEIHTVPTIRSGPPAVNVSVNQ 3688
Query: 256 HVSLLCGADSNPPPLLTWMRDGTVL-----REAVAESLLLELEEVTPAEDGVYACLAENA 310
L C AD P PL++W +D L R + L ++ V + G Y CLA N+
Sbjct: 3689 TALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNS 3748
Query: 311 YGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVI 370
G D + L V+ P + + C +P P++ +K+ Q L +
Sbjct: 3749 AGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRL 3808
Query: 371 YESELQ------LELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL 415
+ + L L A P+D ++ CV N+ G+ + ++V P +
Sbjct: 3809 QQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTI 3859
Score = 65.9 bits (159), Expect = 1e-10
Identities = 53/201 (26%), Positives = 84/201 (41%), Gaps = 15/201 (7%)
Query: 254 GSHVSLLCGADSNPPPLLTWMRDGTVLREAVAES---LLLELEEVTPAEDGVYACLAENA 310
G + L C A +P P + W + + E V+E L+ V+ + G Y C AEN
Sbjct: 4143 GDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENR 4202
Query: 311 YGQDNRTVGLSVMYAPWKPTVNGT----MVAVEGETVSILCSTQSNPDPILTIFKEKQIL 366
G RT +S ++ P + G +V G ++ + C + +P P + K+ L
Sbjct: 4203 VG---RTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPL 4259
Query: 367 STVIYESELQ---LELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAA 423
+LQ L + +D G Y C+AEN+ G L ++ APV +E
Sbjct: 4260 RGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMT 4319
Query: 424 AR--DTVQCLCVVKSNPEPSV 442
R D V C P P++
Sbjct: 4320 VRSGDDVALRCQATGEPTPTI 4340
Score = 65.1 bits (157), Expect = 2e-10
Identities = 80/322 (24%), Positives = 123/322 (38%), Gaps = 43/322 (13%)
Query: 150 VAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVS----LLHFV 205
+ G +E+ C + P + WL + G PA +E VQV+ LH
Sbjct: 1702 IVGQPLELPCQASGSPV---PTIQWLQN---GRPA-------EELAGVQVASQGTTLHID 1748
Query: 206 PTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEM-----------NSSVEAIEG 254
+ CQA+ T E S+ ++ P ++E+ +SS A
Sbjct: 1749 HVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACD 1808
Query: 255 SHVSLLCGADSNPPPLLTWMRDGTVLREA----VAESLL--LELEEVTPAEDGVYACLAE 308
V GA PP + W G++ E VA SL L++E+V ++G+Y C A
Sbjct: 1809 PPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAAT 1868
Query: 309 NAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILS- 367
N G+ R V L V+ P +E +V++ C P P ++ FK Q +S
Sbjct: 1869 NLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSS 1928
Query: 368 ----TVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHC-- 421
TV + + L + D G Y CVA N G + L V P + L
Sbjct: 1929 WMGVTVSVDGRV-LRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPG 1987
Query: 422 -AAARDTVQCLCVVKSNPEPSV 442
V+ C P P++
Sbjct: 1988 PVLVNTPVRLTCNATGAPSPTL 2009
Score = 59.3 bits (142), Expect = 1e-08
Identities = 81/332 (24%), Positives = 128/332 (38%), Gaps = 54/332 (16%)
Query: 148 EVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPT 207
+ VAG V + C+ + P LSW HEGL E +G S+L
Sbjct: 1607 KAVAGRPVALECVARGHPS---PTLSW-HHEGLPVAESNESRLETDG-----SVLRLESP 1657
Query: 208 REANGHRLGCQASFP--NTTLQFEGYASMDVKYPP--VIVEMNSSVEAIEGSHVSLLCGA 263
EA+ C AS P LQ+ S++V+ PP ++ E V I G + L C A
Sbjct: 1658 GEASSGLYSCVASSPAGEAVLQY----SVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQA 1713
Query: 264 DSNPPPLLTWMRDGTVLRE-----AVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTV 318
+P P + W+++G E ++ L ++ V G++AC A N G V
Sbjct: 1714 SGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEV 1773
Query: 319 GLSVMYAPWKPTVNGTMVA------VEGETVSILCSTQ------SNPDPIL--------T 358
+SV + W P V + + C ++P P L +
Sbjct: 1774 EVSV-HGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGS 1832
Query: 359 IFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQ--RATAFNL----SVEFA 412
++ E + V Y L++ V D+G Y C A N G+ R A + ++E
Sbjct: 1833 LWGEPTGI-PVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPG 1891
Query: 413 PVLLLESHCAAARDTVQCLCVVKSNPEPSVAF 444
PV + +V C+ P P V++
Sbjct: 1892 PV----NKAVLENASVTLECLASGVPPPDVSW 1919
Score = 58.2 bits (139), Expect = 2e-08
Identities = 68/255 (26%), Positives = 102/255 (40%), Gaps = 24/255 (9%)
Query: 170 PELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFE 229
P + W ++ P G +D G+ +Q + + +RE +G + C A N + +
Sbjct: 4158 PRIGWTVND---RPVTEGVSEQDGGSTLQRAAV----SREDSGTYV-CWAE--NRVGRTQ 4207
Query: 230 GYASMDVKYPPVIVEMNSS--VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAES 287
+ + VK PV+ S VE + GS + L C +P P + W++DG LR +
Sbjct: 4208 AVSFVHVKEAPVLQGEAFSYLVEPVGGS-IQLDCVVRGDPVPDIHWIKDGLPLRGSHLRH 4266
Query: 288 LL----LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETV 343
L L + + G Y CLAEN G + V L + AP M G+ V
Sbjct: 4267 QLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDV 4326
Query: 344 SILCSTQSNPDPILTIFKEKQILST-----VIYESELQLELPAVSPEDDGEYWCVAENQY 398
++ C P P + + Q L + + L LE V D G Y CVA N
Sbjct: 4327 ALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLE--NVETGDAGTYDCVAHNLL 4384
Query: 399 GQRATAFNLSVEFAP 413
G L V P
Sbjct: 4385 GSATARAFLVVRGEP 4399
Score = 52.8 bits (125), Expect = 1e-06
Identities = 54/231 (23%), Positives = 83/231 (35%), Gaps = 13/231 (5%)
Query: 239 PPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAE-------SLLLE 291
PP I S++ + L C A +P PL+ W +DG L + + S L
Sbjct: 3763 PPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALL 3822
Query: 292 LEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQS 351
L P + + C+ N G+ +R ++V P V + C +
Sbjct: 3823 LTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTG 3882
Query: 352 NPDPILTIFKEKQIL----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNL 407
P P ++ K L S LE+ P G Y C A N G L
Sbjct: 3883 IPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFL 3942
Query: 408 SVEFAPVL--LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNES 456
+V+ +PV+ L A A + V C P P++ ++ NV S
Sbjct: 3943 TVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVS 3993
Score = 48.1 bits (113), Expect = 2e-05
Identities = 40/165 (24%), Positives = 65/165 (39%), Gaps = 6/165 (3%)
Query: 291 ELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQ 350
E+ + AE+G Y C A + G + V P + + GET + C
Sbjct: 482 EILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL 541
Query: 351 SNPDPILTIFKEKQIL----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFN 406
LT ++ ++L V ++L LE+ + P D G Y CVA N G +
Sbjct: 542 GEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVW 601
Query: 407 LSVEFAPVLLL--ESHCAAARDTVQCLCVVKSNPEPSVAFELPSR 449
L V AP + + S + V+ C P P +++ S+
Sbjct: 602 LLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQ 646
Score = 46.6 bits (109), Expect = 7e-05
Identities = 41/162 (25%), Positives = 60/162 (37%), Gaps = 12/162 (7%)
Query: 290 LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCST 349
L L +V + G Y C A N G + L V P + + GE + + C
Sbjct: 1084 LRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVA 1143
Query: 350 QSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSV 409
+ NP+P L+ K+ +L + + A+ D G Y C A N G A L V
Sbjct: 1144 EGNPEPQLSWSKDGVVLQG--RGPQGSVHFAAIRTSDAGRYRCEASNSAGVDAWEVELRV 1201
Query: 410 EFAPVL-------LLESHCAAARDTVQCLCVVKSNPEPSVAF 444
P LLE A + C + P+P V +
Sbjct: 1202 LEPPHWGADETSGLLE---RVAGENASLPCPARGTPKPQVTW 1240
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 95.5 bits (236), Expect = 1e-19
Identities = 93/353 (26%), Positives = 154/353 (43%), Gaps = 33/353 (9%)
Query: 131 EHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLR 190
+H L + +P + P VV E + + RP ++W EGL +
Sbjct: 2656 KHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQ-KEGLNVATGVSTQV 2714
Query: 191 EDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVE 250
G Q+ + H P E G+ L C A N+ G + V+ PPVI +
Sbjct: 2715 LPGG---QLRIAHASP--EDAGNYL-CIAK--NSAGSAMGKTRLVVQVPPVIENGLPDLS 2766
Query: 251 AIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-----VAESLLLELEEVTPAEDGVYAC 305
EGSH L C A +P P +TW +DG + A + S L ++ + + G Y C
Sbjct: 2767 TTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTC 2826
Query: 306 LAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQI 365
AENA G+ R V L+++ P T+ G G+ + + C+ + +P P + +
Sbjct: 2827 TAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRP 2886
Query: 366 LSTVIYESE--LQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAA 423
++ + E + L+ AVS ED G Y C AEN+ G+ + V+ APVL E+
Sbjct: 2887 VTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYL 2946
Query: 424 AR---DTVQCLCVVKSNPEPSVAF--------------ELPSRNVTVNESERE 459
++Q CVV+ +P P + + +L + ++T+ +ER+
Sbjct: 2947 VEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERD 2999
Score = 92.0 bits (227), Expect = 1e-18
Identities = 93/329 (28%), Positives = 138/329 (41%), Gaps = 35/329 (10%)
Query: 143 IVVPPEVVAGTE-------VEVSCMVPDNCPELR---PELSWLGHEGLGEPAVLGRLRED 192
++ PP ++ TE V S V CP L P +SWL + P+ ++ ED
Sbjct: 1556 VLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLED 1615
Query: 193 EGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMN-SSVEA 251
G +QVS A+ C A N E ++ V+ PP I ++ V A
Sbjct: 1616 -GQVLQVSTAEV-----ADAASYMCVAE--NQAGSAEKLFTLRVQVPPRIAGLDLEQVTA 1667
Query: 252 IEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-----LELEEVTPAEDGVYACL 306
I S VSL C ++P P +TW +D L LL L+L ++ G+Y C
Sbjct: 1668 ILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCE 1727
Query: 307 AENAYGQDNRTVGLSVMYAP-WKPTVNGTMVAV---EGETVSILCSTQSNPDPILTIFKE 362
A NA G+D + V LSV+ P ++ G AV G+ + C T + P+P +T +K+
Sbjct: 1728 ALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKD 1787
Query: 363 KQIL----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL--- 415
Q L T +LE+ D G Y C N G+ F L+V+ P
Sbjct: 1788 GQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENP 1847
Query: 416 LLESHCAAARDTVQCLCVVKSNPEPSVAF 444
E+ A + C V P P+V +
Sbjct: 1848 KTETVSQVAGSPLVLTCDVSGVPAPTVTW 1876
Score = 83.2 bits (204), Expect = 7e-16
Identities = 94/419 (22%), Positives = 164/419 (39%), Gaps = 51/419 (12%)
Query: 142 NIVVPPEVVAGTEVEVSCMVPDNCPELR---------PELSWLGHEGLGEPAVLGRLRED 192
+++VPPE++ + + + P P + W E EP G ED
Sbjct: 1063 SVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGE---EPVSPG---ED 1116
Query: 193 EGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIV--EMNSSVE 250
+L T+E + C AS N + S++V PP I ++ ++
Sbjct: 1117 TYLLAGGWMLKMTQTQEQDSGLYSCLAS--NEAGEARRNFSVEVLVPPSIENEDLEEVIK 1174
Query: 251 AIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVA-----ESLLLELEEVTPAEDGVYAC 305
++G L+C +P P LTW +DG L A + +LL++ + + G Y+C
Sbjct: 1175 VLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSC 1234
Query: 306 LAENAYGQDNRTVGLSVMYAPW-----KPTVNGTMVAVEGETVSILCSTQSNPDPILTIF 360
+A NA G+ + LSV+ AP + + + + +S++C + P P +T
Sbjct: 1235 IAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWM 1294
Query: 361 KE----KQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL 416
K+ + + + L++ ED G+Y CV N+ G+ +++ V P +
Sbjct: 1295 KDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSIS 1354
Query: 417 LESHCA---------AARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSG 467
+ A T+ C + P P++ + + VT S R V E
Sbjct: 1355 KDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVT--PSSRLQVLGEGRL 1412
Query: 468 LVLTSILTLRGQAQAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAIL 526
L + Q R +C A N+ G + M+ K+G A AF IL
Sbjct: 1413 LQIQPT-----QVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSA--AFEIL 1464
Score = 83.2 bits (204), Expect = 7e-16
Identities = 70/270 (25%), Positives = 112/270 (41%), Gaps = 17/270 (6%)
Query: 236 VKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-----VAESLLL 290
V PP I + + + V L C + P P ++W + G L V+ S L
Sbjct: 2571 VHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGAL 2630
Query: 291 ELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQ 350
E+ + P G Y C A N+ G ++ V L+V +P + + AV E V + C
Sbjct: 2631 EIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEAS 2690
Query: 351 SNPDPILTIFKEKQILSTVIYESEL---QLELPAVSPEDDGEYWCVAENQYGQRATAFNL 407
P P +T KE ++T + L QL + SPED G Y C+A+N G L
Sbjct: 2691 GIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRL 2750
Query: 408 SVEFAPVLL--LESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSER 465
V+ PV+ L C + +PEP++ ++ + V+ +E +F
Sbjct: 2751 VVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQ--PVSGAEGKFTIQPS 2808
Query: 466 SGLVLTSILTLRGQAQAPPRVICTARNLYG 495
L++ ++ + Q CTA N G
Sbjct: 2809 GELLVKNL-----EGQDAGTYTCTAENAVG 2833
Score = 80.9 bits (198), Expect = 3e-15
Identities = 70/286 (24%), Positives = 117/286 (40%), Gaps = 30/286 (10%)
Query: 234 MDVKYPPVIV---EMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL- 289
++V PP I E + V ++ +L C A PPP +TW RDG + + L
Sbjct: 968 LEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQN 1027
Query: 290 ----LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAP-----WKPTVNGTMVAVEG 340
L +E A G Y+C+AEN G+ R LSV+ P P N + A
Sbjct: 1028 QGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTN--ITAALH 1085
Query: 341 ETVSILCSTQSNPDPILTIFKEKQILS----TVIYESELQLELPAVSPEDDGEYWCVAEN 396
+++LC P P + F+ ++ +S T + L++ +D G Y C+A N
Sbjct: 1086 SPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASN 1145
Query: 397 QYGQRATAFNLSVEFAPVL----LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVT 452
+ G+ F++ V P + L E T +C V +P+P + + R +
Sbjct: 1146 EAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLA 1205
Query: 453 VNESEREFVYSERSGLVLTSILTLRGQAQAPPRVICTARNLYGAKS 498
++ + G++L L+ + C A N G K+
Sbjct: 1206 RGDAH----HISPDGVLLQ---VLQANLSSAGHYSCIAANAVGEKT 1244
Score = 80.1 bits (196), Expect = 6e-15
Identities = 89/371 (23%), Positives = 147/371 (39%), Gaps = 73/371 (19%)
Query: 130 SEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDN--CPELR---PELSWL--------- 175
++H L ++ P I+ E A EV V+ P + C L P ++W+
Sbjct: 1244 TKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEAS 1303
Query: 176 -------GHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQF 228
G GL +L +ED G + V + + + N H + P + +
Sbjct: 1304 RNIQLLPGTHGL---QILNAQKEDAGQYTCV-VTNELGEAVKNYH---VEVLIPPSISKD 1356
Query: 229 EGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLR-----EA 283
+ A + VK V+ S ++L C + + PPP + W +DG + +
Sbjct: 1357 DPLAEVGVK----------EVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQV 1406
Query: 284 VAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVA------ 337
+ E LL+++ ++ G Y C+A N G+D++ + + P V A
Sbjct: 1407 LGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSR 1466
Query: 338 --------------VEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQ----LEL 379
VE + C T + P P LT ++E Q LS S LQ L++
Sbjct: 1467 EEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQI 1526
Query: 380 PAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL------LLESHCAAARDTVQCLCV 433
P V E+ G Y C A N+ G+ + L V PV+ L+E A TV C
Sbjct: 1527 PLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCP 1586
Query: 434 VKSNPEPSVAF 444
NP P++++
Sbjct: 1587 ALGNPVPTISW 1597
Score = 80.1 bits (196), Expect = 6e-15
Identities = 87/368 (23%), Positives = 153/368 (41%), Gaps = 42/368 (11%)
Query: 149 VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSL----LHF 204
V+ G EV + C P P+++WL G P L +D G ++ L L
Sbjct: 1947 VLEGQEVRLDCEADGQPP---PDVAWLKD---GSP-----LGQDMGPHLRFYLDGGSLVL 1995
Query: 205 VPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVI---VEMNSSVEAIEGSHVSLLC 261
R ++ C A N + +++V PP I + + ++ + G V+++C
Sbjct: 1996 KGLRASDAGAYTCVAH--NPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVC 2053
Query: 262 GADSNPPPLLTWMRDGTVLREAVAESL-----LLELEEVTPAEDGVYACLAENAYGQDNR 316
+PP ++W++DG L + L L + +V A+ G++ C+A + G +R
Sbjct: 2054 PVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADR 2113
Query: 317 TVGLSVMYAPWKPTVN--GTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESE 374
L V P V +V V G V + C + P P+++ K+ + L + E
Sbjct: 2114 NFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQG 2173
Query: 375 LQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAAARDT----VQC 430
L+L AV D G Y CVA ++ G+ F L+V P + T ++
Sbjct: 2174 PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMEL 2233
Query: 431 LCVVKSNPEPSVAFELPSRNVT--VNESEREFVYSERSGLVLTSIL---------TLRGQ 479
LC + P+P++ + + +T N S V R + T + + R +
Sbjct: 2234 LCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVR 2293
Query: 480 AQAPPRVI 487
QAPP ++
Sbjct: 2294 VQAPPNIV 2301
Score = 74.7 bits (182), Expect = 2e-13
Identities = 93/383 (24%), Positives = 141/383 (36%), Gaps = 51/383 (13%)
Query: 141 PNIVVPPE----VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTW 196
P I +PP V+ T V ++C P P L WL PA L+ G
Sbjct: 695 PRITLPPSLPGPVLVNTPVRLTCNAT-GAPS--PTLMWLKDGNPVSPAGTPGLQVFPGGR 751
Query: 197 VQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSH 256
V L R ++ R C A + + + V PP I+ +V +
Sbjct: 752 V----LTLASARASDSGRYSCVAV--SAVGEDRQDVVLQVHMPPSILGEELNVSVVANES 805
Query: 257 VSLLCGADSNPPPLLTWMRDGTVLR-----EAVAESLLLELEEVTPAEDGVYACLAENAY 311
V+L C + + PPP+L+W +DG L A+ LL+++ + G Y C A N
Sbjct: 806 VALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQA 865
Query: 312 GQDNRTVGLSVMYAPWKP-TVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQIL---- 366
G + L+V AP P + T+ EG + C + P P ++ K+ Q L
Sbjct: 866 GHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEG 925
Query: 367 ---------STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL- 416
++Y + QL +G Y C N G + L V P +
Sbjct: 926 AGLQHVSAVGRLLYLGQAQL-------AQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAG 978
Query: 417 ---LESHCAAARDTVQCL-CVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTS 472
+ + +D V L C P P+V +E + V + + G S
Sbjct: 979 PREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELG----LQLQNQG---QS 1031
Query: 473 ILTLRGQAQAPPRVICTARNLYG 495
+ R QA R C A NL G
Sbjct: 1032 LHVERAQAAHTGRYSCVAENLAG 1054
Score = 72.4 bits (176), Expect = 1e-12
Identities = 63/229 (27%), Positives = 97/229 (42%), Gaps = 26/229 (11%)
Query: 236 VKYPPVIVEMNSS--VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-----VAESL 288
V PP I N + V +E V LLC A P P +TW +DG +L +
Sbjct: 215 VHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGR 274
Query: 289 LLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNG------TMVAVEGET 342
L+L ++ GVY C A NA G + L V Y P PT+ G + AV G
Sbjct: 275 QLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV-YVP--PTIEGAGGRPYVVKAVAGRP 331
Query: 343 VSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGE-----YWCVAENQ 397
V++ C + +P P L+ + + + ES L+ + + E GE Y CVA +
Sbjct: 332 VALECVARGHPSPTLS-WHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSP 390
Query: 398 YGQRATAFNLSVEFAPVLLLESHCAAARDTV----QCLCVVKSNPEPSV 442
G+ +++ V+ P LL+ V + C +P P++
Sbjct: 391 AGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTI 439
Score = 72.4 bits (176), Expect = 1e-12
Identities = 95/381 (24%), Positives = 143/381 (37%), Gaps = 53/381 (13%)
Query: 134 VLDIVNTPNIVVPPEVVAGTEVEVSCM---VPDNCPELRPELSWLGHEGLGEPAVLGRLR 190
VL+ V N VV VV G+ VE+ C VP P +SW+ GEP + L
Sbjct: 2124 VLEPVEFQNDVV---VVRGSLVELPCEARGVP------LPLVSWMKD---GEPLLSQSLE 2171
Query: 191 EDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYA----SMDVKYPPVIVEMN 246
+ P+ + G ++ + G A + V PP I +
Sbjct: 2172 QG-------------PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSG 2218
Query: 247 SSVEA--IEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDGVYA 304
E G+ + LLC A P P +TW +DG L S + V A G+Y
Sbjct: 2219 QPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDA--GLYT 2276
Query: 305 CLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAV---EGETVSILCSTQSNPDPILTIFK 361
CLAE+ G ++ + V P G V G+ V + CS ++ P P +T +
Sbjct: 2277 CLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLV-LECSVEAEPAPKITWHR 2335
Query: 362 EKQILS----TVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLL 417
+ +L T E L+L A+S D G+Y C A N G + AF + + P +
Sbjct: 2336 DGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRS 2395
Query: 418 ESHC--AAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILT 475
+ T C P P V++ V ++ F L + +L
Sbjct: 2396 GPPAVNVSVNQTALLPCQADGVPAPLVSWR--KDRVPLDPRSPRFEILPEGSLRIQPVL- 2452
Query: 476 LRGQAQAPPRVICTARNLYGA 496
AQ +C A N G+
Sbjct: 2453 ----AQDAGHYLCLASNSAGS 2469
Score = 69.7 bits (169), Expect = 8e-12
Identities = 50/200 (25%), Positives = 86/200 (43%), Gaps = 20/200 (10%)
Query: 233 SMDVKYPPVIVEMNS-SVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-- 289
++ V+ PP + +V + GS + L C P P +TW++D + + ++
Sbjct: 1835 TLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSR 1894
Query: 290 ---LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVA-----VEGE 341
L+L + PA+ G Y C+AEN + + ++V+ A P + + VA +EG+
Sbjct: 1895 GGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVA---PRIRSSGVAREHHVLEGQ 1951
Query: 342 TVSILCSTQSNPDPILTIFKEKQILSTVI------YESELQLELPAVSPEDDGEYWCVAE 395
V + C P P + K+ L + Y L L + D G Y CVA
Sbjct: 1952 EVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAH 2011
Query: 396 NQYGQRATAFNLSVEFAPVL 415
N G+ A ++V P +
Sbjct: 2012 NPAGEDARLHTVNVLVPPTI 2031
Score = 65.9 bits (159), Expect = 1e-10
Identities = 64/291 (21%), Positives = 117/291 (40%), Gaps = 27/291 (9%)
Query: 141 PNIVVP--PEVVAGT---EVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGT 195
PNIV P P V G ++ + C V E P+++W +G+ + G
Sbjct: 2298 PNIVGPRGPRFVVGLAPGQLVLECSVE---AEPAPKITW-HRDGIVLQEDAHTQFPERGR 2353
Query: 196 WVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGS 255
++Q+ L T ++ + + + +T++ F +++ P I +V
Sbjct: 2354 FLQLQALS---TADSGDYSCTARNAAGSTSVAFR----VEIHTVPTIRSGPPAVNVSVNQ 2406
Query: 256 HVSLLCGADSNPPPLLTWMRDGTVL-----REAVAESLLLELEEVTPAEDGVYACLAENA 310
L C AD P PL++W +D L R + L ++ V + G Y CLA N+
Sbjct: 2407 TALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNS 2466
Query: 311 YGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVI 370
G D + L V+ P + + C +P P++ +K+ Q L +
Sbjct: 2467 AGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRL 2526
Query: 371 YESELQ------LELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL 415
+ + L L A P+D ++ CV N+ G+ + ++V P +
Sbjct: 2527 QQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTI 2577
Score = 65.9 bits (159), Expect = 1e-10
Identities = 53/201 (26%), Positives = 84/201 (41%), Gaps = 15/201 (7%)
Query: 254 GSHVSLLCGADSNPPPLLTWMRDGTVLREAVAES---LLLELEEVTPAEDGVYACLAENA 310
G + L C A +P P + W + + E V+E L+ V+ + G Y C AEN
Sbjct: 2861 GDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENR 2920
Query: 311 YGQDNRTVGLSVMYAPWKPTVNGT----MVAVEGETVSILCSTQSNPDPILTIFKEKQIL 366
G RT +S ++ P + G +V G ++ + C + +P P + K+ L
Sbjct: 2921 VG---RTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPL 2977
Query: 367 STVIYESELQ---LELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAA 423
+LQ L + +D G Y C+AEN+ G L ++ APV +E
Sbjct: 2978 RGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMT 3037
Query: 424 AR--DTVQCLCVVKSNPEPSV 442
R D V C P P++
Sbjct: 3038 VRSGDDVALRCQATGEPTPTI 3058
Score = 65.1 bits (157), Expect = 2e-10
Identities = 80/322 (24%), Positives = 123/322 (38%), Gaps = 43/322 (13%)
Query: 150 VAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVS----LLHFV 205
+ G +E+ C + P + WL + G PA +E VQV+ LH
Sbjct: 420 IVGQPLELPCQASGSPV---PTIQWLQN---GRPA-------EELAGVQVASQGTTLHID 466
Query: 206 PTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEM-----------NSSVEAIEG 254
+ CQA+ T E S+ ++ P ++E+ +SS A
Sbjct: 467 HVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACD 526
Query: 255 SHVSLLCGADSNPPPLLTWMRDGTVLREA----VAESLL--LELEEVTPAEDGVYACLAE 308
V GA PP + W G++ E VA SL L++E+V ++G+Y C A
Sbjct: 527 PPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAAT 586
Query: 309 NAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILS- 367
N G+ R V L V+ P +E +V++ C P P ++ FK Q +S
Sbjct: 587 NLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSS 646
Query: 368 ----TVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHC-- 421
TV + + L + D G Y CVA N G + L V P + L
Sbjct: 647 WMGVTVSVDGRV-LRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPG 705
Query: 422 -AAARDTVQCLCVVKSNPEPSV 442
V+ C P P++
Sbjct: 706 PVLVNTPVRLTCNATGAPSPTL 727
Score = 64.7 bits (156), Expect = 2e-10
Identities = 62/248 (25%), Positives = 96/248 (38%), Gaps = 51/248 (20%)
Query: 239 PPVIVE--MNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVL---------------- 280
PP I E ++V + G ++L C A+ P P + W++D ++
Sbjct: 16 PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWG 75
Query: 281 ----REAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMV 336
+ E L + + G+Y+C AEN G R L V+ P +V G
Sbjct: 76 QVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPP---SVLGAGA 132
Query: 337 AVE-----GETVSILCSTQSNPDPILTIFKEKQIL-----STVIYESELQLELPAVSPED 386
A E G V + C T P P + K++Q + + E L + D
Sbjct: 133 AQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGD 192
Query: 387 DGEYWCVAENQYGQRATAFNLSVEFAP----------VLLLESHCAAARDTVQCLCVVKS 436
+G Y CVA + GQ+A F L V P V ++E H VQ LC +
Sbjct: 193 EGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDH------LVQLLCEARG 246
Query: 437 NPEPSVAF 444
P P++ +
Sbjct: 247 VPTPNITW 254
Score = 59.3 bits (142), Expect = 1e-08
Identities = 81/332 (24%), Positives = 128/332 (38%), Gaps = 54/332 (16%)
Query: 148 EVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPT 207
+ VAG V + C+ + P LSW HEGL E +G S+L
Sbjct: 325 KAVAGRPVALECVARGHPS---PTLSW-HHEGLPVAESNESRLETDG-----SVLRLESP 375
Query: 208 REANGHRLGCQASFP--NTTLQFEGYASMDVKYPP--VIVEMNSSVEAIEGSHVSLLCGA 263
EA+ C AS P LQ+ S++V+ PP ++ E V I G + L C A
Sbjct: 376 GEASSGLYSCVASSPAGEAVLQY----SVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQA 431
Query: 264 DSNPPPLLTWMRDGTVLRE-----AVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTV 318
+P P + W+++G E ++ L ++ V G++AC A N G V
Sbjct: 432 SGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEV 491
Query: 319 GLSVMYAPWKPTVNGTMVA------VEGETVSILCSTQ------SNPDPIL--------T 358
+SV + W P V + + C ++P P L +
Sbjct: 492 EVSV-HGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGS 550
Query: 359 IFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQ--RATAFNL----SVEFA 412
++ E + V Y L++ V D+G Y C A N G+ R A + ++E
Sbjct: 551 LWGEPTGI-PVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPG 609
Query: 413 PVLLLESHCAAARDTVQCLCVVKSNPEPSVAF 444
PV + +V C+ P P V++
Sbjct: 610 PV----NKAVLENASVTLECLASGVPPPDVSW 637
Score = 58.2 bits (139), Expect = 2e-08
Identities = 68/255 (26%), Positives = 102/255 (40%), Gaps = 24/255 (9%)
Query: 170 PELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFE 229
P + W ++ P G +D G+ +Q + + +RE +G + C A N + +
Sbjct: 2876 PRIGWTVND---RPVTEGVSEQDGGSTLQRAAV----SREDSGTYV-CWAE--NRVGRTQ 2925
Query: 230 GYASMDVKYPPVIVEMNSS--VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAES 287
+ + VK PV+ S VE + GS + L C +P P + W++DG LR +
Sbjct: 2926 AVSFVHVKEAPVLQGEAFSYLVEPVGGS-IQLDCVVRGDPVPDIHWIKDGLPLRGSHLRH 2984
Query: 288 LL----LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETV 343
L L + + G Y CLAEN G + V L + AP M G+ V
Sbjct: 2985 QLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDV 3044
Query: 344 SILCSTQSNPDPILTIFKEKQILST-----VIYESELQLELPAVSPEDDGEYWCVAENQY 398
++ C P P + + Q L + + L LE V D G Y CVA N
Sbjct: 3045 ALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLE--NVETGDAGTYDCVAHNLL 3102
Query: 399 GQRATAFNLSVEFAP 413
G L V P
Sbjct: 3103 GSATARAFLVVRGEP 3117
Score = 52.8 bits (125), Expect = 1e-06
Identities = 54/231 (23%), Positives = 83/231 (35%), Gaps = 13/231 (5%)
Query: 239 PPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAE-------SLLLE 291
PP I S++ + L C A +P PL+ W +DG L + + S L
Sbjct: 2481 PPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALL 2540
Query: 292 LEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQS 351
L P + + C+ N G+ +R ++V P V + C +
Sbjct: 2541 LTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTG 2600
Query: 352 NPDPILTIFKEKQIL----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNL 407
P P ++ K L S LE+ P G Y C A N G L
Sbjct: 2601 IPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFL 2660
Query: 408 SVEFAPVL--LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNES 456
+V+ +PV+ L A A + V C P P++ ++ NV S
Sbjct: 2661 TVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVS 2711
>gi|130979981 CD33 antigen isoform 1 precursor [Homo sapiens]
Length = 364
Score = 93.6 bits (231), Expect = 5e-19
Identities = 75/249 (30%), Positives = 101/249 (40%), Gaps = 23/249 (9%)
Query: 1 MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFP----DELRPAVVH 56
M L LPL W A W + S++ EG CV +PC F P D+ P VH
Sbjct: 1 MPLLLLLPLLWAGALAMDPNFW-LQVQESVTVQEGLCVLVPCTFFHPIPYYDKNSP--VH 57
Query: 57 GVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYY 116
G W+ PV Q V E QGR RLLGD NC+L + + G Y+
Sbjct: 58 GYWFREGAIISRDSPVATNKLDQEVQEETQGRFRLLGDPSRNNCSLSIVDARRRDNGSYF 117
Query: 117 FRGDLG----GYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPEL 172
FR + G Y S H V D+ + P I++P + G ++C V C + P +
Sbjct: 118 FRMERGSTKYSYKSPQLSVH-VTDLTHRPKILIPGTLEPGHSKNLTCSVSWACEQGTPPI 176
Query: 173 -SWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGY 231
SWL P LG S+L P + +G L CQ F + E
Sbjct: 177 FSWLS----AAPTSLG------PRTTHSSVLIITPRPQDHGTNLTCQVKFAGAGVTTERT 226
Query: 232 ASMDVKYPP 240
++V Y P
Sbjct: 227 IQLNVTYVP 235
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 90.1 bits (222), Expect = 5e-18
Identities = 103/384 (26%), Positives = 151/384 (39%), Gaps = 45/384 (11%)
Query: 141 PNIVVPPE---VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLRE-DEGTW 196
P I P+ V +G V +C N +PE+ WL + RL D+GT
Sbjct: 246 PRITSEPQDADVTSGNTVYFTCRAEGNP---KPEIIWLRNNNELSMKTDSRLNLLDDGT- 301
Query: 197 VQVSLLHFVPTREANGHRLGCQAS-------FPNTTLQFEGYASMDVKYPPVIVEMNSSV 249
L T+E + C A TL++ G + P V +
Sbjct: 302 -----LMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPAR-----PTFVIQPQNT 351
Query: 250 EAIEGSHVSLLCGADSNPPPLLTWMR-DGTVL----REAVAESLLLELEEVTPAEDGVYA 304
E + G V+L C A +PPP ++W R D T L R + S L ++ V + G YA
Sbjct: 352 EVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYA 411
Query: 305 CLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQ 364
C A N + T + V P V +EG+TV C + NP P++ K
Sbjct: 412 CSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGS 471
Query: 365 ILST---VIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVE--FAPVL--LL 417
LS + S L + V+ D G+Y C A N G + +L+V+ PV +
Sbjct: 472 QLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIP 531
Query: 418 ESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLR 477
VQ C + PEP++ + V V ES + F S L + +
Sbjct: 532 SDTTVEVGANVQLPCSSQGEPEPAITWN--KDGVQVTESGK-FHISPEGFLTINDV---- 584
Query: 478 GQAQAPPRVICTARNLYGAKSLEL 501
G A A R C ARN G+ S+ +
Sbjct: 585 GPADA-GRYECVARNTIGSASVSM 607
Score = 74.7 bits (182), Expect = 2e-13
Identities = 73/287 (25%), Positives = 109/287 (37%), Gaps = 25/287 (8%)
Query: 141 PNIVVPP---EVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPA-VLGRLREDEGTW 196
P V+ P EV+ G V + C + P P +SW + P + G +
Sbjct: 342 PTFVIQPQNTEVLVGESVTLECSATGHPP---PRISWTRGDRTPLPVDPRVNITPSGGLY 398
Query: 197 VQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSH 256
+Q + + + C A+ N A + V+ P IEG
Sbjct: 399 IQNVV-------QGDSGEYACSAT--NNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQT 449
Query: 257 VSLLCGADSNPPPLLTWMRDGTVL----REAVAESLLLELEEVTPAEDGVYACLAENAYG 312
V C A NPPP++ W + G+ L R V S L + V + G Y C A N G
Sbjct: 450 VDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIG 509
Query: 313 QDNRTVGLSVM--YAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEK-QILSTV 369
L+V P ++ G V + CS+Q P+P +T K+ Q+ +
Sbjct: 510 SQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESG 569
Query: 370 IYESELQ--LELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPV 414
+ + L + V P D G Y CVA N G + + LSV V
Sbjct: 570 KFHISPEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSVNVPDV 616
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 87.8 bits (216), Expect = 3e-17
Identities = 93/374 (24%), Positives = 151/374 (40%), Gaps = 29/374 (7%)
Query: 137 IVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTW 196
+V PN+ V P G +SC V P L+W+ + PA GR+ +
Sbjct: 403 LVPAPNVTVSP----GETAVLSCRVLGEAPY---NLTWV-RDWRVLPASTGRVAQLADLS 454
Query: 197 VQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSH 256
+++S + +PT +G R C AS N + + + V+ P + SS +G
Sbjct: 455 LEISGI--IPT---DGGRYQCVASNANGVTRASVW--LLVREAPQVSIHTSSQHFSQGVE 507
Query: 257 VSLLCGADSNPPPLLTWMRDGTVLREA----VAESLLLELEEVTPAEDGVYACLAENAYG 312
V + C A P P ++W R+ L+E V L ++ V P + G Y+C A N G
Sbjct: 508 VKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVG 567
Query: 313 QDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFK-EKQILSTVIY 371
D TV L P VN ++ GE ++C P P + ++ +++
Sbjct: 568 TDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEG 627
Query: 372 ESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL--LLESHCAAARDTVQ 429
S +L +PA D G Y C A N+ G + L+V AP L L +
Sbjct: 628 SSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSAL 687
Query: 430 CLCVVKSNPEPSVAF---ELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQAQAPPRV 486
C P P+V + + + + SG++ ++ + QAP
Sbjct: 688 LACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFE--SVAPEDQAP--Y 743
Query: 487 ICTARNLYGAKSLE 500
+C ARN++G E
Sbjct: 744 VCEARNVFGKVQAE 757
Score = 76.3 bits (186), Expect = 8e-14
Identities = 95/371 (25%), Positives = 134/371 (36%), Gaps = 34/371 (9%)
Query: 149 VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTR 208
V G ++C P P ++W +G LG R +L F
Sbjct: 680 VELGRSALLACRATGRPP---PTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVA 736
Query: 209 EANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPP 268
+ C+A +Q E + PP I +V +EG VSL C + P
Sbjct: 737 PEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRP 796
Query: 269 -PLLTWMRDGTVL----REAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVM 323
P W++DG L R ++ L L+ G Y+C+A N G +R V L V
Sbjct: 797 LPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQ 856
Query: 324 YAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILST------VIYESELQL 377
P + EG S+ C P P +T KE L++ V E L +
Sbjct: 857 VPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLI 916
Query: 378 ELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESH---------CAAARDTV 428
P S +D G Y C A N G + LSV P + + A A + V
Sbjct: 917 AQP--SAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEV 974
Query: 429 QCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTL-RGQAQAPPRVI 487
C K +P P V + SR V + R GL+ + L L + Q
Sbjct: 975 TLDCEAKGSPPPLVTWTKDSRPVP--------PITNRYGLLPSGSLRLAQVQVGDSGHYE 1026
Query: 488 CTARNLYGAKS 498
CTA N G+ S
Sbjct: 1027 CTASNPAGSAS 1037
Score = 74.3 bits (181), Expect = 3e-13
Identities = 55/176 (31%), Positives = 77/176 (43%), Gaps = 8/176 (4%)
Query: 232 ASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVL-----REAVAE 286
A + V PP + +V G L C P LTW+RD VL R A
Sbjct: 392 AQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLA 451
Query: 287 SLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSIL 346
L LE+ + P + G Y C+A NA G +V L V AP + +G V +
Sbjct: 452 DLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVS 511
Query: 347 CSTQSNPDPILTIFKEKQIL---STVIYESELQLELPAVSPEDDGEYWCVAENQYG 399
CS P P ++ +E Q L S + +++ L + V+PED G Y C A N+ G
Sbjct: 512 CSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVG 567
Score = 68.6 bits (166), Expect = 2e-11
Identities = 71/279 (25%), Positives = 110/279 (39%), Gaps = 29/279 (10%)
Query: 149 VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTR 208
V+ G V + C+V P PE WL P +R D LH
Sbjct: 779 VLEGQPVSLPCIVLAGRP--LPERHWLKDGRPLPPGSRHSIRADGS-------LHLDRAL 829
Query: 209 EANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPP 268
+ + R C A+ NT + V+ PP I + EG SL C A P
Sbjct: 830 QEHAGRYSCVAT--NTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPA 887
Query: 269 PLLTWMRDGTVLREA-----VAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVM 323
P +TW ++ L V++ L + + + + G Y C A N G ++ + LSV
Sbjct: 888 PTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVN 947
Query: 324 YAPWKPTVNGT--------MVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESEL 375
P + +NG+ + A GE V++ C + +P P++T K+ + + + L
Sbjct: 948 TKP-RIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGL 1006
Query: 376 ----QLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVE 410
L L V D G Y C A N G + + L V+
Sbjct: 1007 LPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQ 1045
Score = 48.1 bits (113), Expect = 2e-05
Identities = 40/165 (24%), Positives = 65/165 (39%), Gaps = 6/165 (3%)
Query: 291 ELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQ 350
E+ + AE+G Y C A + G + V P + + GET + C
Sbjct: 365 EILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL 424
Query: 351 SNPDPILTIFKEKQIL----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFN 406
LT ++ ++L V ++L LE+ + P D G Y CVA N G +
Sbjct: 425 GEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVW 484
Query: 407 LSVEFAPVLLL--ESHCAAARDTVQCLCVVKSNPEPSVAFELPSR 449
L V AP + + S + V+ C P P +++ S+
Sbjct: 485 LLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQ 529
Score = 44.7 bits (104), Expect = 3e-04
Identities = 29/87 (33%), Positives = 39/87 (44%), Gaps = 6/87 (6%)
Query: 249 VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVL-----REAVAESLLLELEEVTPAEDGVY 303
V A G V+L C A +PPPL+TW +D + R + S L L +V + G Y
Sbjct: 966 VTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHY 1025
Query: 304 ACLAENAYGQDNRTVGLSVM-YAPWKP 329
C A N G + L V W+P
Sbjct: 1026 ECTASNPAGSASHRYVLGVQGRTSWQP 1052
>gi|4507875 vascular cell adhesion molecule 1 isoform a precursor
[Homo sapiens]
Length = 739
Score = 86.7 bits (213), Expect = 6e-17
Identities = 95/366 (25%), Positives = 152/366 (41%), Gaps = 31/366 (8%)
Query: 74 FKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYNQYTFSEHS 133
F RTQ+ G+ R G N TL LS VS E Y G +
Sbjct: 345 FSWRTQI-DSPLSGKVRSEGT----NSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVE 399
Query: 134 VLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDE 193
+ P I + +V G+ V VSC VP P R E+ L E + E + +
Sbjct: 400 LYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMK 459
Query: 194 GTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEG---------YASMDVKYPPVIVE 244
+ + F+PT E G L CQA ++FE Y ++ + V+V
Sbjct: 460 SLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVS 519
Query: 245 MNSSVEAIEGSHVSLLCGADSNPPPLLTWMR---DGTVLREAVAESLLLELEEVTPAEDG 301
+S +E EGS V++ C + P P + W R +G + + ++E+ L L + G
Sbjct: 520 PSSILE--EGSSVNMTCLSQGFPAPKILWSRQLPNGEL--QPLSENATLTLISTKMEDSG 575
Query: 302 VYACLAENAYGQDNRTVGLSVMYAPW--KPTVNGTMVAVEGETVSILCSTQSNPDPILTI 359
VY C N G+ + V L + P K T + EG+TV I C+ + P+ + +
Sbjct: 576 VYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIIL 635
Query: 360 FKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVE--------F 411
K+ + TV+ + + +D G Y C ++N+ G + + L V+ F
Sbjct: 636 KKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYF 695
Query: 412 APVLLL 417
+P LL+
Sbjct: 696 SPELLV 701
Score = 51.6 bits (122), Expect = 2e-06
Identities = 51/227 (22%), Positives = 93/227 (40%), Gaps = 14/227 (6%)
Query: 141 PNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVS 200
P I + + AG + V C V D P R E+ L + L + + + +
Sbjct: 119 PEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSL 178
Query: 201 LLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPV-------IVEMNSSVEAIE 253
+ F P E G L C+A + VK V ++ +N S + E
Sbjct: 179 EVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQE 238
Query: 254 GSHVSLLCGADSNPPPLLTWMR---DGTVLREAVAESLLLELEEVTPAEDGVYACLAENA 310
G V++ C ++ P P + W + +G + + ++ + L L + + G+Y C N
Sbjct: 239 GGSVTMTCSSEGLPAPEIFWSKKLDNGNL--QHLSGNATLTLIAMRMEDSGIYVCEGVNL 296
Query: 311 YGQDNRTVGLSVMYAPWKPTVN-GTMVAVE-GETVSILCSTQSNPDP 355
G++ + V L V P+ ++ G +A + G++V + CS P
Sbjct: 297 IGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESP 343
Score = 34.7 bits (78), Expect = 0.27
Identities = 31/119 (26%), Positives = 48/119 (40%), Gaps = 4/119 (3%)
Query: 330 TVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGE 389
+VN + EG +V++ CS++ P P + K+ + L L A+ ED G
Sbjct: 229 SVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGI 288
Query: 390 YWCVAENQYGQRATAFNLSVEFAPVLLLESH----CAAARDTVQCLCVVKSNPEPSVAF 444
Y C N G+ L V+ P + S A D+V C V PS ++
Sbjct: 289 YVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSW 347
>gi|18201909 vascular cell adhesion molecule 1 isoform b precursor
[Homo sapiens]
Length = 647
Score = 85.5 bits (210), Expect = 1e-16
Identities = 91/342 (26%), Positives = 147/342 (42%), Gaps = 28/342 (8%)
Query: 99 NCTLLLSNVSPELGGKYYFRG-DLGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEV 157
N TL L + E G Y G +L G N+ E V P I + +V G+ V V
Sbjct: 273 NATLTLIAMRMEDSGIYVCEGVNLIGKNRKEV-ELIVQAFPRDPEIEMSGGLVNGSSVTV 331
Query: 158 SCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGC 217
SC VP P R E+ L E + E + + + + F+PT E G L C
Sbjct: 332 SCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVC 391
Query: 218 QASFPNTTLQFEG---------YASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPP 268
QA ++FE Y ++ + V+V +S +E EGS V++ C + P
Sbjct: 392 QAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILE--EGSSVNMTCLSQGFPA 449
Query: 269 PLLTWMR---DGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYA 325
P + W R +G + + ++E+ L L + GVY C N G+ + V L +
Sbjct: 450 PKILWSRQLPNGEL--QPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVT 507
Query: 326 PW--KPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVS 383
P K T + EG+TV I C+ + P+ + + K+ + TV+ + +
Sbjct: 508 PKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQ 567
Query: 384 PEDDGEYWCVAENQYGQRATAFNLSVE--------FAPVLLL 417
+D G Y C ++N+ G + + L V+ F+P LL+
Sbjct: 568 LKDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLV 609
Score = 54.7 bits (130), Expect = 3e-07
Identities = 111/506 (21%), Positives = 197/506 (38%), Gaps = 61/506 (12%)
Query: 141 PNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVS 200
P I + + AG + V C V D P R E+ L + L + + + +
Sbjct: 119 PEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSL 178
Query: 201 LLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPV-------IVEMNSSVEAIE 253
+ F P E G L C+A + VK V ++ +N S + E
Sbjct: 179 EVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQE 238
Query: 254 GSHVSLLCGADSNPPPLLTWMR---DGTVLREAVAESLLLELEEVTPAEDGVYACLAENA 310
G V++ C ++ P P + W + +G + + ++ + L L + + G+Y C N
Sbjct: 239 GGSVTMTCSSEGLPAPEIFWSKKLDNGNL--QHLSGNATLTLIAMRMEDSGIYVCEGVNL 296
Query: 311 YGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPI----LTIFKEKQIL 366
G++ + V L V P P + + V G +V++ C S P+ + + K + IL
Sbjct: 297 IGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPS-VYPLDRLEIELLKGETIL 355
Query: 367 STVIYESELQLE-----------LPAVSPEDDGE-YWCVA-------ENQYGQRATAFNL 407
+ + + ++ +P + ED G+ C A E + QR + L
Sbjct: 356 ENIEFLEDTDMKSLENKSLEMTFIPTI--EDTGKALVCQAKLHIDDMEFEPKQRQSTQTL 413
Query: 408 SVEFAP----VLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYS 463
V AP VL+ S +V C+ + P P + L SR + E + S
Sbjct: 414 YVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKI---LWSRQLPNGELQ---PLS 467
Query: 464 ERSGLVLTSILTLRGQAQAPPRVICTARNLYG--AKSLELPFQGAHRLMWAKIGPVGAV- 520
E + L L S + + +C N G K +EL Q + + P +V
Sbjct: 468 ENATLTLIST-----KMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVK 522
Query: 521 VAFAILIAIVC-YITQT---RRKKNVTESPSFSAGDNPPVLFSSDFRISGAPEKYESERR 576
++I+ C + +T +KK T + D + + + +G E ES+ +
Sbjct: 523 EGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYE-CESKNK 581
Query: 577 LGSERRLLGLRGEPPELDLSYSHSDL 602
+GS+ R L L + E + Y +L
Sbjct: 582 VGSQLRSLTLDVQGRENNKDYFSPEL 607
>gi|145275174 kin of IRRE-like 2 isoform c [Homo sapiens]
Length = 708
Score = 85.1 bits (209), Expect = 2e-16
Identities = 122/467 (26%), Positives = 179/467 (38%), Gaps = 44/467 (9%)
Query: 142 NIVVPPE---VVAGTEVEVSCMVPDNCP-------ELRPELSWLGHEGLGEPAVLGRLRE 191
+++VPPE V+ G V + VP N PEL W L + A +
Sbjct: 118 HVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLL 177
Query: 192 DEGTWVQV-SLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVE 250
EGT V S L P +G C+A + ++ ++YPP + S
Sbjct: 178 KEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHT 237
Query: 251 AIEGSHVSLLCGADSNPPPL-LTWMRDGTVLREAVAESLLLELEEVTPAEDGVYACLAEN 309
EG V LC A + PP W + G+ + A L + + E +C N
Sbjct: 238 VQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEP--VSCEVSN 295
Query: 310 AYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTV 369
A G NR+ L V++ P + GE S C+ + NP P +T +
Sbjct: 296 AVGSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG---GAQ 352
Query: 370 IYESELQLELPAVSPEDDGEYWCVAE-NQYGQR--ATAFNLSVEFAPVL-LLESHCAAAR 425
+ S L LP+V PED G+Y C AE G R A L+V PV+ L S A R
Sbjct: 353 VLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLR 412
Query: 426 DTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVY------SERSGL--VLTSILTLR 477
+ C+V ++P P S+ F+ R GL L S+L +
Sbjct: 413 GPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHIS 472
Query: 478 G--QAQAPPRVICTARNLYGAKSLELPFQGAHRLMWAKI--GPVGAVVAFAILI---AIV 530
G ++ C+ARN G + L +I G A ++I A+
Sbjct: 473 GTQESDFSRSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALC 532
Query: 531 CYITQTRRKKNVTESPSFSAGDN-PPVLFSSDFRISGAPEKYESERR 576
C+ ++ S SFS N + SSD S PE+ E+ R
Sbjct: 533 CW-------RHSKASASFSEQKNLMRIPGSSDGSSSRGPEEEETGSR 572
>gi|145275172 kin of IRRE-like 2 isoform b [Homo sapiens]
Length = 583
Score = 85.1 bits (209), Expect = 2e-16
Identities = 122/467 (26%), Positives = 179/467 (38%), Gaps = 44/467 (9%)
Query: 142 NIVVPPE---VVAGTEVEVSCMVPDNCP-------ELRPELSWLGHEGLGEPAVLGRLRE 191
+++VPPE V+ G V + VP N PEL W L + A +
Sbjct: 68 HVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLL 127
Query: 192 DEGTWVQV-SLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVE 250
EGT V S L P +G C+A + ++ ++YPP + S
Sbjct: 128 KEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHT 187
Query: 251 AIEGSHVSLLCGADSNPPPL-LTWMRDGTVLREAVAESLLLELEEVTPAEDGVYACLAEN 309
EG V LC A + PP W + G+ + A L + + E +C N
Sbjct: 188 VQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEP--VSCEVSN 245
Query: 310 AYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTV 369
A G NR+ L V++ P + GE S C+ + NP P +T +
Sbjct: 246 AVGSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG---GAQ 302
Query: 370 IYESELQLELPAVSPEDDGEYWCVAE-NQYGQR--ATAFNLSVEFAPVL-LLESHCAAAR 425
+ S L LP+V PED G+Y C AE G R A L+V PV+ L S A R
Sbjct: 303 VLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLR 362
Query: 426 DTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVY------SERSGL--VLTSILTLR 477
+ C+V ++P P S+ F+ R GL L S+L +
Sbjct: 363 GPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHIS 422
Query: 478 G--QAQAPPRVICTARNLYGAKSLELPFQGAHRLMWAKI--GPVGAVVAFAILI---AIV 530
G ++ C+ARN G + L +I G A ++I A+
Sbjct: 423 GTQESDFSRSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALC 482
Query: 531 CYITQTRRKKNVTESPSFSAGDN-PPVLFSSDFRISGAPEKYESERR 576
C+ ++ S SFS N + SSD S PE+ E+ R
Sbjct: 483 CW-------RHSKASASFSEQKNLMRIPGSSDGSSSRGPEEEETGSR 522
>gi|145275170 kin of IRRE-like 2 isoform a [Homo sapiens]
Length = 633
Score = 85.1 bits (209), Expect = 2e-16
Identities = 122/467 (26%), Positives = 179/467 (38%), Gaps = 44/467 (9%)
Query: 142 NIVVPPE---VVAGTEVEVSCMVPDNCP-------ELRPELSWLGHEGLGEPAVLGRLRE 191
+++VPPE V+ G V + VP N PEL W L + A +
Sbjct: 118 HVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLL 177
Query: 192 DEGTWVQV-SLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVE 250
EGT V S L P +G C+A + ++ ++YPP + S
Sbjct: 178 KEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHT 237
Query: 251 AIEGSHVSLLCGADSNPPPL-LTWMRDGTVLREAVAESLLLELEEVTPAEDGVYACLAEN 309
EG V LC A + PP W + G+ + A L + + E +C N
Sbjct: 238 VQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEP--VSCEVSN 295
Query: 310 AYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTV 369
A G NR+ L V++ P + GE S C+ + NP P +T +
Sbjct: 296 AVGSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG---GAQ 352
Query: 370 IYESELQLELPAVSPEDDGEYWCVAE-NQYGQR--ATAFNLSVEFAPVL-LLESHCAAAR 425
+ S L LP+V PED G+Y C AE G R A L+V PV+ L S A R
Sbjct: 353 VLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLR 412
Query: 426 DTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVY------SERSGL--VLTSILTLR 477
+ C+V ++P P S+ F+ R GL L S+L +
Sbjct: 413 GPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHIS 472
Query: 478 G--QAQAPPRVICTARNLYGAKSLELPFQGAHRLMWAKI--GPVGAVVAFAILI---AIV 530
G ++ C+ARN G + L +I G A ++I A+
Sbjct: 473 GTQESDFSRSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALC 532
Query: 531 CYITQTRRKKNVTESPSFSAGDN-PPVLFSSDFRISGAPEKYESERR 576
C+ ++ S SFS N + SSD S PE+ E+ R
Sbjct: 533 CW-------RHSKASASFSEQKNLMRIPGSSDGSSSRGPEEEETGSR 572
>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
sapiens]
Length = 1248
Score = 83.6 bits (205), Expect = 5e-16
Identities = 99/376 (26%), Positives = 154/376 (40%), Gaps = 44/376 (11%)
Query: 144 VVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEG-TWVQVSLL 202
V P EV G V + C P + LR + W+ + L +++DE T Q L
Sbjct: 138 VKPVEVEEGESVVLPCNPPPSAEPLR--IYWMNSKIL-------HIKQDERVTMGQNGNL 188
Query: 203 HFVPTREANGHR-LGCQASFPNTT---------LQFEGYASMDVKYPPVIVEMNSS--VE 250
+F ++ H C A FP T L+ + SM + P ++ NSS +
Sbjct: 189 YFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLV 248
Query: 251 AIEGSHVSLLCGADSNPPPLLTWMR-DGTVLREAVA---ESLLLELEEVTPAEDGVYACL 306
A++G + L C A+ P P + W+R G + + V + L+L +V +DG Y CL
Sbjct: 249 ALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCL 308
Query: 307 AENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQIL 366
AEN+ G ++V AP+ + + GET + C Q P P +T +
Sbjct: 309 AENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPV 368
Query: 367 STVIYESELQLE-----LPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLL---- 417
+ + + +++ L V P D C A N++G + V P +L
Sbjct: 369 EELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADN 428
Query: 418 ESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLR 477
+++ A T LC P PSV + L TV + ER F Y+ L +R
Sbjct: 429 QTYMAVQGSTAYLLCKAFGAPVPSVQW-LDEDGTTVLQDERFFPYA-------NGTLGIR 480
Query: 478 G-QAQAPPRVICTARN 492
QA R C A N
Sbjct: 481 DLQANDTGRYFCLAAN 496
Score = 65.1 bits (157), Expect = 2e-10
Identities = 48/167 (28%), Positives = 82/167 (49%), Gaps = 13/167 (7%)
Query: 335 MVAVEGETVSILCSTQSNPDPILTIFKEKQILST--VIYESELQ-LELPAVSPEDDGEYW 391
+VA++G+ + + C + P P + + + V Y++ + L+L V EDDGEY
Sbjct: 247 LVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYR 306
Query: 392 CVAENQYGQRATAFNLSVEFAPVLL--LESHCAAARDTVQCLCVVKSNPEPSVAFELPSR 449
C+AEN G A+ ++VE AP L +SH +T + C V+ P+P V + +
Sbjct: 307 CLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRI--N 364
Query: 450 NVTVNESEREFVYS-ERSGLVLTSILTLRGQAQAPPRVICTARNLYG 495
+ V E ++ Y +R L+L+++ Q C ARN +G
Sbjct: 365 GIPVEELAKDQKYRIQRGALILSNV-----QPSDTMVTQCEARNRHG 406
Score = 52.8 bits (125), Expect = 1e-06
Identities = 59/241 (24%), Positives = 95/241 (39%), Gaps = 27/241 (11%)
Query: 254 GSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL------LELEEVTPAEDGVYACLA 307
G L C P P +TW +G + E + L L V P++ V C A
Sbjct: 342 GETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEA 401
Query: 308 ENAYGQDNRTVGLSVMYAPWKPTV--NGTMVAVEGETVSILCSTQSNPDPILTIFKEKQI 365
N +G + V+ P K N T +AV+G T +LC P P + E
Sbjct: 402 RNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDG- 460
Query: 366 LSTVIYESEL------QLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFA------P 413
+TV+ + L + + D G Y+C+A N NL V+ A P
Sbjct: 461 -TTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGP 519
Query: 414 VLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNV-TVNESEREFVYSERSGLVLTS 472
+E +R T C + +PS+ + R++ + +S++ F+ E LV+ S
Sbjct: 520 RSTIEK--KGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFI--EDGRLVIHS 575
Query: 473 I 473
+
Sbjct: 576 L 576
Score = 40.4 bits (93), Expect = 0.005
Identities = 57/247 (23%), Positives = 88/247 (35%), Gaps = 37/247 (14%)
Query: 239 PPVIVEMNSS-VEAIEGSHVSLLCGADSNPPPLLTWMRDG-----------TVLREAVAE 286
PPVI E + + +SL C A P W RDG TV + +
Sbjct: 29 PPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSG 88
Query: 287 SLLLELEEVTPAE--DGVYACLAENAYGQD-NRTVGLSVMYAP-WKPTVNGTMVAVEGET 342
S + A+ G+Y C A N G + + L AP W + EGE+
Sbjct: 89 SFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGES 148
Query: 343 VSILCSTQSNPDPILTIFKEKQIL-----STVIYESELQLELPAVSPEDD-GEYWC---- 392
V + C+ + +P+ + +IL V L V D+ +Y C
Sbjct: 149 VVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHF 208
Query: 393 ------VAENQYGQRATAFNLSVEFAPVLLL----ESHCAAARDTVQCL-CVVKSNPEPS 441
+ + R A N ++ P LL SH A + L C+ + P P+
Sbjct: 209 PGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPT 268
Query: 442 VAFELPS 448
+ + PS
Sbjct: 269 IKWLRPS 275
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,332,778
Number of Sequences: 37866
Number of extensions: 1258121
Number of successful extensions: 6313
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 202
Number of HSP's successfully gapped in prelim test: 190
Number of HSP's that attempted gapping in prelim test: 2970
Number of HSP's gapped (non-prelim): 1760
length of query: 626
length of database: 18,247,518
effective HSP length: 108
effective length of query: 518
effective length of database: 14,157,990
effective search space: 7333838820
effective search space used: 7333838820
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.