BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|11225258 myelin associated glycoprotein isoform a precursor [Homo sapiens] (626 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|11225258 myelin associated glycoprotein isoform a precursor [... 1270 0.0 gi|18104957 myelin associated glycoprotein isoform b precursor [... 1167 0.0 gi|31377639 sialic acid binding Ig-like lectin 10 [Homo sapiens] 190 3e-48 gi|205830470 sialic acid binding Ig-like lectin 11 isoform 1 [Ho... 171 2e-42 gi|13489095 sialoadhesin precursor [Homo sapiens] 143 4e-34 gi|205830473 sialic acid binding Ig-like lectin 11 isoform 2 [Ho... 139 1e-32 gi|7657570 sialic acid binding Ig-like lectin 7 isoform 1 [Homo ... 128 1e-29 gi|94538343 sialic acid binding Ig-like lectin 8 [Homo sapiens] 127 4e-29 gi|4502659 sialic acid binding Ig-like lectin 5 [Homo sapiens] 121 2e-27 gi|23943856 sialic acid binding Ig-like lectin 9 [Homo sapiens] 119 8e-27 gi|16506826 sialic acid binding immunoglobulin-like lectin-like ... 118 1e-26 gi|16506828 sialic acid binding immunoglobulin-like lectin-like ... 118 1e-26 gi|193794821 sialic acid binding Ig-like lectin 6 isoform 1 prec... 115 9e-26 gi|157168355 CD22 molecule [Homo sapiens] 115 1e-25 gi|193794819 sialic acid binding Ig-like lectin 6 isoform 2 prec... 114 3e-25 gi|148762980 sialic acid binding Ig-like lectin 14 [Homo sapiens] 110 5e-24 gi|193794817 sialic acid binding Ig-like lectin 6 isoform 3 prec... 109 9e-24 gi|118572606 hemicentin 1 [Homo sapiens] 99 1e-20 gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 96 1e-19 gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 96 1e-19 gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 96 1e-19 gi|130979981 CD33 antigen isoform 1 precursor [Homo sapiens] 94 5e-19 gi|109150416 peroxidasin [Homo sapiens] 90 5e-18 gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 88 3e-17 gi|4507875 vascular cell adhesion molecule 1 isoform a precursor... 87 6e-17 gi|18201909 vascular cell adhesion molecule 1 isoform b precurso... 86 1e-16 gi|145275174 kin of IRRE-like 2 isoform c [Homo sapiens] 85 2e-16 gi|145275172 kin of IRRE-like 2 isoform b [Homo sapiens] 85 2e-16 gi|145275170 kin of IRRE-like 2 isoform a [Homo sapiens] 85 2e-16 gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo... 84 5e-16 >gi|11225258 myelin associated glycoprotein isoform a precursor [Homo sapiens] Length = 626 Score = 1270 bits (3287), Expect = 0.0 Identities = 626/626 (100%), Positives = 626/626 (100%) Query: 1 MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWY 60 MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWY Sbjct: 1 MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWY 60 Query: 61 FNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGD 120 FNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGD Sbjct: 61 FNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGD 120 Query: 121 LGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGL 180 LGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGL Sbjct: 121 LGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGL 180 Query: 181 GEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP 240 GEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP Sbjct: 181 GEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP 240 Query: 241 VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAED 300 VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAED Sbjct: 241 VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAED 300 Query: 301 GVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIF 360 GVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIF Sbjct: 301 GVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIF 360 Query: 361 KEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESH 420 KEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESH Sbjct: 361 KEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESH 420 Query: 421 CAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQA 480 CAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQA Sbjct: 421 CAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQA 480 Query: 481 QAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKK 540 QAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKK Sbjct: 481 QAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKK 540 Query: 541 NVTESPSFSAGDNPPVLFSSDFRISGAPEKYESERRLGSERRLLGLRGEPPELDLSYSHS 600 NVTESPSFSAGDNPPVLFSSDFRISGAPEKYESERRLGSERRLLGLRGEPPELDLSYSHS Sbjct: 541 NVTESPSFSAGDNPPVLFSSDFRISGAPEKYESERRLGSERRLLGLRGEPPELDLSYSHS 600 Query: 601 DLGKRPTKDSYTLTEELAEYAEIRVK 626 DLGKRPTKDSYTLTEELAEYAEIRVK Sbjct: 601 DLGKRPTKDSYTLTEELAEYAEIRVK 626 >gi|18104957 myelin associated glycoprotein isoform b precursor [Homo sapiens] Length = 582 Score = 1167 bits (3019), Expect = 0.0 Identities = 573/574 (99%), Positives = 574/574 (100%) Query: 1 MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWY 60 MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWY Sbjct: 1 MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWY 60 Query: 61 FNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGD 120 FNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGD Sbjct: 61 FNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGD 120 Query: 121 LGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGL 180 LGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGL Sbjct: 121 LGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGL 180 Query: 181 GEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP 240 GEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP Sbjct: 181 GEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP 240 Query: 241 VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAED 300 VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAED Sbjct: 241 VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAED 300 Query: 301 GVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIF 360 GVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIF Sbjct: 301 GVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIF 360 Query: 361 KEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESH 420 KEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESH Sbjct: 361 KEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESH 420 Query: 421 CAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQA 480 CAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQA Sbjct: 421 CAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQA 480 Query: 481 QAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKK 540 QAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKK Sbjct: 481 QAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKK 540 Query: 541 NVTESPSFSAGDNPPVLFSSDFRISGAPEKYESE 574 NVTESPSFSAGDNPPVLFSSDFRISGAPEKYES+ Sbjct: 541 NVTESPSFSAGDNPPVLFSSDFRISGAPEKYESK 574 >gi|31377639 sialic acid binding Ig-like lectin 10 [Homo sapiens] Length = 697 Score = 190 bits (483), Expect = 3e-48 Identities = 164/587 (27%), Positives = 256/587 (43%), Gaps = 63/587 (10%) Query: 15 SASRGGHWGAWMPSSISAFEGTCVSIPCRFDFP--DELRPAVVHGVWYFNSPYPKNYPPV 72 S + G + + S+ EG C+S+PC F +P D +G W+ PV Sbjct: 14 SQAMDGRFWIRVQESVMVPEGLCISVPCSFSYPRQDWTGSTPAYGYWFKAVTETTKGAPV 73 Query: 73 VFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYNQYTFSEH 132 +++ V S +GR +L GD NC+L++ + + +Y+FR + G Y +Y F Sbjct: 74 ATNHQSREVEMSTRGRFQLTGDPAKGNCSLVIRDAQMQDESQYFFRVERGSYVRYNFMND 133 Query: 133 ----SVLDIVNTPNIVVPPEVVAGTEVEVSCMVP---DNCPELRPELSWLGHEGLGEPAV 185 V + P++ +P + G V V C+ + CP P SW G A Sbjct: 134 GFFLKVTALTQKPDVYIPETLEPGQPVTVICVFNWAFEECPP--PSFSWTG-------AA 184 Query: 186 LGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEM 245 L + + T S+L F P + + L C F + + + V Y P + + Sbjct: 185 LSS-QGTKPTTSHFSVLSFTPRPQDHNTDLTCHVDFSRKGVSAQRTVRLRVAYAPRDLVI 243 Query: 246 NSS-----------------VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA---VA 285 + S +EA +G + LLC ADS PP L+W+ VL + Sbjct: 244 SISRDNTPALEPQPQGNVPYLEAQKGQFLRLLCAADSQPPATLSWVLQNRVLSSSHPWGP 303 Query: 286 ESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTV-------------- 331 L LEL V + G Y C AEN G R + LSV Y P V Sbjct: 304 RPLGLELPGVKAGDSGRYTCRAENRLGSQQRALDLSVQYPPENLRVMVSQANRTVLENLG 363 Query: 332 NGTMVAV-EGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEY 390 NGT + V EG+++ ++C T S+P L+ + Q+LS LELP V E +GE+ Sbjct: 364 NGTSLPVLEGQSLCLVCVTHSSPPARLSWTQRGQVLSPSQPSDPGVLELPRVQVEHEGEF 423 Query: 391 WCVAENQYGQRATAFNLSVEFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRN 450 C A + G + + +LSV ++P LL S C+ + + C C +++P PS+ + L Sbjct: 424 TCHARHPLGSQHVSLSLSVHYSPKLLGPS-CSWEAEGLHCSCSSQASPAPSLRWWLGEEL 482 Query: 451 VTVNESEREF-VYSERSGLVLTSILTLRGQAQAPPRVICTARNLYGAKS---LELP-FQG 505 + N S+ F V +G S L+L G + R+ C A N++GA+S L+LP +G Sbjct: 483 LEGNSSQDSFEVTPSSAGPWANSSLSLHGGLSSGLRLRCEAWNVHGAQSGSILQLPDKKG 542 Query: 506 AHRLMWAKIGPVG---AVVAFAILIAIVCYITQTRRKKNVTESPSFS 549 ++ +G + F L I+ I RR + T P FS Sbjct: 543 LISTAFSNGAFLGIGITALLFLCLALIIMKILPKRRTQTETPRPRFS 589 >gi|205830470 sialic acid binding Ig-like lectin 11 isoform 1 [Homo sapiens] Length = 698 Score = 171 bits (432), Expect = 2e-42 Identities = 143/510 (28%), Positives = 226/510 (44%), Gaps = 58/510 (11%) Query: 34 EGTCVSIPCRFDFP----DELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRS 89 EG CV + C +P DE A +G W+ PK PV ++++ V S + R Sbjct: 46 EGLCVIVSCNLSYPRDGWDESTAA--YGYWFKGRTSPKTGAPVATNNQSREVEMSTRDRF 103 Query: 90 RLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYNQYTFSEHS----VLDIVNTPNIVV 145 +L GD G +C+L++ + E Y+FR + G +++F ++ V + P++ + Sbjct: 104 QLTGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTALTKKPDVYI 163 Query: 146 PPEVVAGTEVEVSCMVP---DNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLL 202 P + G V V C+ CP P SW G A L R T S+L Sbjct: 164 PETLEPGQPVTVICVFNWAFKKCP--APSFSWTG-------AALSPRRTRPST-SHFSVL 213 Query: 203 HFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP---VIVEMNSSVEAIE------ 253 F P+ + + L C F + + + V Y P +I + + A+E Sbjct: 214 SFTPSPQDHDTDLTCHVDFSRKGVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVI 273 Query: 254 ------GSHVSLLCGADSNPPPLLTWMRDGTVLREA---VAESLLLELEEVTPAEDGVYA 304 G + LLC ADS PP L+W+ VL + +L LEL V + G Y Sbjct: 274 YLEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYT 333 Query: 305 CLAENAYGQDNRTVGLSVMYAPWKPTV--------------NGTMVAV-EGETVSILCST 349 C AEN G + + LSV Y P V NGT + V EG+++ ++C T Sbjct: 334 CRAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVT 393 Query: 350 QSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSV 409 S+P L+ + Q + LELP + E +GE+ C A++ G + + +LSV Sbjct: 394 HSSPPARLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQHPLGSQHVSLSLSV 453 Query: 410 EFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREF-VYSERSGL 468 + P LL S C+ + + C C +++P PS+ + L + N S+ F V +G Sbjct: 454 HYPPQLLGPS-CSWEAEGLHCSCSSQASPAPSLRWWLGEELLEGNSSQGSFEVTPSSAGP 512 Query: 469 VLTSILTLRGQAQAPPRVICTARNLYGAKS 498 S L+L G + R+ C A N++GA+S Sbjct: 513 WANSSLSLHGGLSSGLRLRCKAWNVHGAQS 542 >gi|13489095 sialoadhesin precursor [Homo sapiens] Length = 1709 Score = 143 bits (361), Expect = 4e-34 Identities = 111/422 (26%), Positives = 200/422 (47%), Gaps = 26/422 (6%) Query: 7 LPLFWIMISASRGGH--WGAWMPSSISAFEGTCVSIPCRFDFPDELR-PAVVHGVWYFNS 63 LP ++ S G WG P + +G+C+ IPC F FP ++ P + +WY++ Sbjct: 4 LPKLLLLASFFPAGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYD- 62 Query: 64 PYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGG 123 Y V + ++V F+GR+ +G+ R C LLL ++ PE G Y FR ++ Sbjct: 63 -YSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISE 121 Query: 124 YNQYTFSEHSVLDIV---NTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGL 180 N+++ + +++ + P I P E++ GTEV+ +C P C + + L W G + Sbjct: 122 VNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPA 181 Query: 181 GEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP 240 + E G + LH + + +G L CQ S N Q E + VKY P Sbjct: 182 RSVTFNSQKFEPTGVG-HLETLHMAMSWQDHGRILRCQLSVANHRAQSE--IHLQVKYAP 238 Query: 241 VIVEM---NSSVEAIEGSHVSLLCGADSNPPPL--LTWMRDGTVLREAVAESLLLELEEV 295 V++ S + G V+L C +S+ P + + W++DG L+ ++ +L L + Sbjct: 239 KGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQ---TKTGVLHLPQA 295 Query: 296 TPAEDGVYACLAENAYGQ-DNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSN-P 353 ++ GVY C AEN G + + L + A + + G + +E +TV+++C+T + P Sbjct: 296 AWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPI--LENQTVTLVCNTPNEAP 353 Query: 354 DPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYG-QRATAFNLSVEFA 412 + + + +L + L+L L + D G Y+C +N +G +R+ ++ V Sbjct: 354 SDLRYSWYKNHVLLEDAHSHTLRLHL--ATRADTGFYFCEVQNVHGSERSGPVSVVVNHP 411 Query: 413 PV 414 P+ Sbjct: 412 PL 413 Score = 61.6 bits (148), Expect = 2e-09 Identities = 51/218 (23%), Positives = 89/218 (40%), Gaps = 18/218 (8%) Query: 243 VEMNSSVEAIEGSHVSLLCGADSNPPPLL--TWMRDGTVLREAVAESLLLELEEVTPAED 300 V+++ + +E V+L+C + P L +W ++ +L +A + +L L L T A+ Sbjct: 328 VQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHL--ATRADT 385 Query: 301 GVYACLAENAYGQDNR-TVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTI 359 G Y C +N +G + V + V + P P + + G + CS S P L + Sbjct: 386 GFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVL 445 Query: 360 FKEKQILSTVIYESE-------------LQLELPAVSPEDDGEYWCVAENQYGQRATAFN 406 IL++ +S+ L+LE+ + D GEY C A N G + + Sbjct: 446 SHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLD 505 Query: 407 LSVEFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVAF 444 A +L+ + V C +P P F Sbjct: 506 FHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARF 543 Score = 59.7 bits (143), Expect = 8e-09 Identities = 64/237 (27%), Positives = 99/237 (41%), Gaps = 34/237 (14%) Query: 187 GRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMN 246 G + EDEG ++ C+AS NT Q A D + V V Sbjct: 1056 GAMLEDEGVYI-------------------CEAS--NTLGQASASADFDAQAVNVQVWPG 1094 Query: 247 SSVEAIEGSHVSLLCGADSNPPPLLT--WMRDGTVLREAVAESLLLELEEVTPAEDGVYA 304 ++V EG V+L C + P LT W +DG +A + + L VT + Y Sbjct: 1095 ATVR--EGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHS----IPLPNVTVRDATSYR 1148 Query: 305 CLA--ENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKE 362 C + +R + L V+YAP + + + G+ +LC+ S P L + Sbjct: 1149 CGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHA 1208 Query: 363 KQILSTVIYES---ELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL 416 ++L++ S L+LEL P D+G Y C A + GQ T+ L +E V+L Sbjct: 1209 GRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVIL 1265 Score = 59.3 bits (142), Expect = 1e-08 Identities = 95/388 (24%), Positives = 150/388 (38%), Gaps = 59/388 (15%) Query: 194 GTWVQ---VSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVE 250 G W+Q + L F+ A+ CQA T A++ V Y P ++S + Sbjct: 1298 GRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRP-AALQVLYAPQDAVLSSFRD 1356 Query: 251 AIEGSHVSLLCGADSNPPPLLTWMRDGTVLR---------------EAVAESLLLELEEV 295 + S + C DS PP L DG VL + +L L++++V Sbjct: 1357 SRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV 1416 Query: 296 TPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDP 355 PA D Y C A+N G + L V A + + EG +++ C P P Sbjct: 1417 -PAGDDTYVCTAQNLLGSISTIGRLQVEGA--RVVAEPGLDVPEGAALNLSCRLLGGPGP 1473 Query: 356 I-----LTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATA-FNLSV 409 + + ++++ + E L V+ G Y C+AE G A+A L V Sbjct: 1474 VGNSTFAWFWNDRRLHA----EPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRV 1529 Query: 410 EFAP----VLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSER 465 + P +++ R + C V S P S+ L SR V S+ + +E Sbjct: 1530 LYPPKTPTMMVFVEPEGGLRGILDCR--VDSEPLASLTLHLGSR--LVASSQPQGAPAEP 1585 Query: 466 SGLVLTSILTLRGQAQA-----PPRVICTARNLYGAKSLELPF--QGAHR------LMWA 512 VL S LR +A IC+A N+ G+ S F + HR L+W Sbjct: 1586 HIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVRALHRLHQFQQLLWV 1645 Query: 513 KIGPVGAVVAFAILIAIV--CYITQTRR 538 +G +V +L+ + CY + RR Sbjct: 1646 ----LGLLVGLLLLLLGLGACYTWRRRR 1669 Score = 58.9 bits (141), Expect = 1e-08 Identities = 58/249 (23%), Positives = 98/249 (39%), Gaps = 22/249 (8%) Query: 253 EGSHVSLLCGAD---SNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDGVYAC-LAE 308 EG+ +L C + P +W R+G + + E++ L V + +YAC + Sbjct: 721 EGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETVTLL--PVARTDAALYACRILT 778 Query: 309 NAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILST 368 A Q + V LSV+Y P +P ++ + +G +C+ S P +L +F + +L+T Sbjct: 779 EAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLAT 838 Query: 369 VI--------------YESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPV 414 + + L+LE+ + D G Y C A N G T+ V A V Sbjct: 839 SLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWV 898 Query: 415 LLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSIL 474 + S V C V + ++ + ES + + + LT Sbjct: 899 QVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATL--RFAAITLTQAG 956 Query: 475 TLRGQAQAP 483 QAQAP Sbjct: 957 AYHCQAQAP 965 Score = 57.4 bits (137), Expect = 4e-08 Identities = 58/249 (23%), Positives = 95/249 (38%), Gaps = 37/249 (14%) Query: 243 VEMNSSVEAIEGSHVSLLCGADSNPPPLLT--WMRDGTVLREAVAESLLLELEEVTPAED 300 V+++ S E EG V L C + P + W RDG L+E+ S L +T + Sbjct: 898 VQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQEST--SATLRFAAITLTQA 955 Query: 301 GVYACLAE---NAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPIL 357 G Y C A+ +A + L V YAP T+ M G +LC S+P L Sbjct: 956 GAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQL 1015 Query: 358 TIFKEKQILSTVIY-----------------ESELQLELPAVSPEDDGEYWCVAENQYGQ 400 + +++++ + + L+LE+ ED+G Y C A N GQ Sbjct: 1016 RLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQ 1075 Query: 401 RATAFNLSVEFAPVLLLESHCAAARDTVQCLCVV-------------KSNPEPSVAFELP 447 + + + + V + V C+V + + A +P Sbjct: 1076 ASASADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSIP 1135 Query: 448 SRNVTVNES 456 NVTV ++ Sbjct: 1136 LPNVTVRDA 1144 Score = 55.1 bits (131), Expect = 2e-07 Identities = 52/228 (22%), Positives = 89/228 (39%), Gaps = 31/228 (13%) Query: 245 MNSSVEAIEGSHVSLLCGADSNPPP--LLTWMRDGTVLREAVAESLLLELEEVTPAEDGV 302 ++ + E +EG V+L C + +P P +W +G +L E SLLL T A G Sbjct: 515 ISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSSLLLPAASSTDA--GS 572 Query: 303 YACLAENAYGQDNRT--VGLSVMYAPWKPTVNGTMV-----AVEGETVSILCSTQSNPDP 355 Y C A + + + L+V+Y P +PT + A G +LC S+P Sbjct: 573 YHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPA 632 Query: 356 ILTIFKEKQILSTVIYESE--------------------LQLELPAVSPEDDGEYWCVAE 395 L + + ++++T + L++E+ E++G Y C A Sbjct: 633 RLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEAS 692 Query: 396 NQYGQRATAFNLSVEFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVA 443 N G +T+ + + + + SH C V S A Sbjct: 693 NALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPA 740 Score = 54.3 bits (129), Expect = 3e-07 Identities = 95/398 (23%), Positives = 144/398 (36%), Gaps = 70/398 (17%) Query: 147 PEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVP 206 PE+ G V +SC V PE W + + LR T Q H Sbjct: 904 PELQEGQAVVLSCQVHTGVPE-GTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYH--- 959 Query: 207 TREANGHRLGCQASFPNT-TLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADS 265 CQA P + T S+ V Y P V + + ++ G LLC DS Sbjct: 960 ----------CQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDS 1009 Query: 266 NPPPLLTWMR---------------DGTVLREAVA---ESLLLELEEVTPAEDGVYACLA 307 +PP L + +G+ R VA +L LE+ ++GVY C A Sbjct: 1010 DPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEA 1069 Query: 308 ENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILS 367 N GQ + + + T+ EG+ V++ C ++ Q+ Sbjct: 1070 SNTLGQASASADFDAQAVNVQVWPGATV--REGQLVNLTC--------LVWTTHPAQLTY 1119 Query: 368 TVIYESELQLE-----LPAVSPEDDGEYWCVA--ENQYGQRATAFNLSVEFAP-----VL 415 T + + +L+ LP V+ D Y C + + + L V +AP Sbjct: 1120 TWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTY 1179 Query: 416 LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILT 475 LLESH LC V S P +A ++ + R S + + T L Sbjct: 1180 LLESH---GGQLALVLCTVDSRPPAQLA---------LSHAGRLLASSTAASVPNTLRLE 1227 Query: 476 LRG-QAQAPPRVICTARNLYGA--KSLELPFQGAHRLM 510 LRG Q + C+AR+ G SLEL +G ++ Sbjct: 1228 LRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVIL 1265 Score = 47.8 bits (112), Expect = 3e-05 Identities = 44/182 (24%), Positives = 71/182 (39%), Gaps = 19/182 (10%) Query: 230 GYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAE--- 286 G S+ V +PP+ + + +E G L C S P L G +L + Sbjct: 402 GPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDH 461 Query: 287 -----------SLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTM 335 SL LE+ ++ + G Y C A N+ G T+ A + ++ Sbjct: 462 SPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAA--RLLISPAA 519 Query: 336 VAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESE-LQLELPAVSPEDDGEYWCVA 394 VEG+ V++ C + +P P + +++E L LPA S D G Y C A Sbjct: 520 EVVEGQAVTLSCRSGLSPTPDARF--SWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRA 577 Query: 395 EN 396 + Sbjct: 578 RD 579 Score = 45.8 bits (107), Expect = 1e-04 Identities = 63/282 (22%), Positives = 100/282 (35%), Gaps = 39/282 (13%) Query: 152 GTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSL--LHFVPTRE 209 GTE ++C V E G PA R W Q L + +P Sbjct: 722 GTEANLTCNV--------------SREAAGSPANFSWFRNGV-LWAQGPLETVTLLPVAR 766 Query: 210 ANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPP 269 + C+ Q + V YPP ++++ ++ +G +C DS P Sbjct: 767 TDAALYACRI-LTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLA 825 Query: 270 LLTWMR---------------DGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQD 314 LL G +A A SL LE+ E+ + G Y C A N G Sbjct: 826 LLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSS 885 Query: 315 NRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESE 374 N ++ V A W V+ + EG+ V + C + P T ++ + + + Sbjct: 886 NTSLFFQVRGA-W-VQVSPSPELQEGQAVVLSCQVHTGV-PEGTSYRWYRDGQPLQESTS 942 Query: 375 LQLELPAVSPEDDGEYWCVAE---NQYGQRATAFNLSVEFAP 413 L A++ G Y C A+ + A +L V +AP Sbjct: 943 ATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAP 984 >gi|205830473 sialic acid binding Ig-like lectin 11 isoform 2 [Homo sapiens] Length = 602 Score = 139 bits (349), Expect = 1e-32 Identities = 116/422 (27%), Positives = 182/422 (43%), Gaps = 56/422 (13%) Query: 34 EGTCVSIPCRFDFP----DELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRS 89 EG CV + C +P DE A +G W+ PK PV ++++ V S + R Sbjct: 46 EGLCVIVSCNLSYPRDGWDESTAA--YGYWFKGRTSPKTGAPVATNNQSREVEMSTRDRF 103 Query: 90 RLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYNQYTFSEHS----VLDIVNTPNIVV 145 +L GD G +C+L++ + E Y+FR + G +++F ++ V + P++ + Sbjct: 104 QLTGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTALTKKPDVYI 163 Query: 146 PPEVVAGTEVEVSCMVP---DNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLL 202 P + G V V C+ CP P SW G A L R T S+L Sbjct: 164 PETLEPGQPVTVICVFNWAFKKCP--APSFSWTG-------AALSPRRTRPST-SHFSVL 213 Query: 203 HFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP---VIVEMNSSVEAIE------ 253 F P+ + + L C F + + + V Y P +I + + A+E Sbjct: 214 SFTPSPQDHDTDLTCHVDFSRKGVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVI 273 Query: 254 ------GSHVSLLCGADSNPPPLLTWMRDGTVLREA---VAESLLLELEEVTPAEDGVYA 304 G + LLC ADS PP L+W+ VL + +L LEL V + G Y Sbjct: 274 YLEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYT 333 Query: 305 CLAENAYGQDNRTVGLSVMYAPWKPTV--------------NGTMVAV-EGETVSILCST 349 C AEN G + + LSV Y P V NGT + V EG+++ ++C T Sbjct: 334 CRAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVT 393 Query: 350 QSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSV 409 S+P L+ + Q + LELP + E +GE+ C A++ G + + +LSV Sbjct: 394 HSSPPARLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQHPLGSQHVSLSLSV 453 Query: 410 EF 411 + Sbjct: 454 HW 455 Score = 47.8 bits (112), Expect = 3e-05 Identities = 36/115 (31%), Positives = 55/115 (47%), Gaps = 17/115 (14%) Query: 316 RTVGLSVMYAPWKPTVN------------GTMVAVE---GETVSILCSTQSNPDPILTIF 360 RTV L V YAP ++ G ++ +E G+ + +LC+ S P L+ Sbjct: 241 RTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFLRLLCAADSQPPATLSWV 300 Query: 361 KEKQILSTVIY--ESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAP 413 + ++LS+ L LEL V D G Y C AEN+ G + A +LSV++ P Sbjct: 301 LQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTCRAENRLGSQQQALDLSVQYPP 355 >gi|7657570 sialic acid binding Ig-like lectin 7 isoform 1 [Homo sapiens] Length = 467 Score = 128 bits (322), Expect = 1e-29 Identities = 98/368 (26%), Positives = 163/368 (44%), Gaps = 39/368 (10%) Query: 1 MIFLTALPLFW----IMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFP--DELRPAV 54 M+ L LPL W + S + M SS++ EG CV + C F +P + Sbjct: 1 MLLLLLLPLLWGRERVEGQKSNRKDYSLTMQSSVTVQEGMCVHVRCSFSYPVDSQTDSDP 60 Query: 55 VHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGK 114 VHG W+ PV + V E + R LLGD +NCTL + + G+ Sbjct: 61 VHGYWFRAGNDISWKAPVATNNPAWAVQEETRDRFHLLGDPQTKNCTLSIRDARMSDAGR 120 Query: 115 YYFRGDLGGYN-QYTFSEHSV--LDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPE-LRP 170 Y+FR + G Y + + SV + + PNI++P + +G ++C VP C + P Sbjct: 121 YFFRMEKGNIKWNYKYDQLSVNVTALTHRPNILIPGTLESGCFQNLTCSVPWACEQGTPP 180 Query: 171 ELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEG 230 +SW+G + + + S+L +P + +G L CQ + P + Sbjct: 181 MISWMGTS----------VSPLHPSTTRSSVLTLIPQPQHHGTSLTCQVTLPGAGVTTNR 230 Query: 231 YASMDVKYPPVIVEM---------------NSSVEAIEGSHVSLLCGADSNPPPLLTW-M 274 ++V YPP + + +SS+ +EG + L+C DSNPP L+W Sbjct: 231 TIQLNVSYPPQNLTVTVFQGEGTASTALGNSSSLSVLEGQSLRLVCAVDSNPPARLSWTW 290 Query: 275 RDGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVM--YAPWKPTVN 332 R T+ + L+LEL +V ++G + C A+N+ G + ++ LS+ Y V+ Sbjct: 291 RSLTLYPSQPSNPLVLEL-QVHLGDEGEFTCRAQNSLGSQHVSLNLSLQQEYTGKMRPVS 349 Query: 333 GTMVAVEG 340 G ++ G Sbjct: 350 GVLLGAVG 357 Score = 47.8 bits (112), Expect = 3e-05 Identities = 42/165 (25%), Positives = 70/165 (42%), Gaps = 19/165 (11%) Query: 264 DSNPPPLLTWMRDG-TVLREAVAESLLLELEEVTPAEDGVYACLAE--NAYGQDNRTVGL 320 + PP+++WM + L + S +L L C A NRT+ L Sbjct: 175 EQGTPPMISWMGTSVSPLHPSTTRSSVLTLIPQPQHHGTSLTCQVTLPGAGVTTNRTIQL 234 Query: 321 SVMYAPWKPTV---------------NGTMVAVEGETVSILCSTQSNPDPILTIFKEKQI 365 +V Y P TV + ++ +EG+++ ++C+ SNP L+ Sbjct: 235 NVSYPPQNLTVTVFQGEGTASTALGNSSSLSVLEGQSLRLVCAVDSNPPARLSWTWRSLT 294 Query: 366 LSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVE 410 L + L LEL V D+GE+ C A+N G + + NLS++ Sbjct: 295 LYPSQPSNPLVLELQ-VHLGDEGEFTCRAQNSLGSQHVSLNLSLQ 338 >gi|94538343 sialic acid binding Ig-like lectin 8 [Homo sapiens] Length = 499 Score = 127 bits (318), Expect = 4e-29 Identities = 99/381 (25%), Positives = 160/381 (41%), Gaps = 45/381 (11%) Query: 1 MIFLTALPLFWIMISASRGGHWG----AWMPSSISAFEGTCVSIPCRFDFPDE--LRPAV 54 ++ L LPL W +G + ++ EG CV +PC F +P + Sbjct: 2 LLLLLLLPLLWGTKGMEGDRQYGDGYLLQVQELVTVQEGLCVHVPCSFSYPQDGWTDSDP 61 Query: 55 VHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGK 114 VHG W+ P PV + + V QGR +LLGD+ +C+L + + G Sbjct: 62 VHGYWFRAGDRPYQDAPVATNNPDREVQAETQGRFQLLGDIWSNDCSLSIRDARKRDKGS 121 Query: 115 YYFRGDLGGYN-------QYTFSEHSVL--DIVNTPNIVVPPEVVAGTEVEVSCMVPDNC 165 Y+FR + G Y + SV + + P+I++ + +G ++C VP C Sbjct: 122 YFFRLERGSMKWSYKSQLNYKTKQLSVFVTALTHRPDILILGTLESGHSRNLTCSVPWAC 181 Query: 166 PE-LRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNT 224 + P +SW+G + T + S+L P + +G L CQ + P T Sbjct: 182 KQGTPPMISWIG----------ASVSSPGPTTARSSVLTLTPKPQDHGTSLTCQVTLPGT 231 Query: 225 TLQFEGYASMDVKYPPVIVEM---------------NSSVEAIEGSHVSLLCGADSNPPP 269 + +DV YPP + M SS+ +EG + L+C +SNPP Sbjct: 232 GVTTTSTVRLDVSYPPWNLTMTVFQGDATASTALGNGSSLSVLEGQSLRLVCAVNSNPPA 291 Query: 270 LLTWMRDG-TVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVM---YA 325 L+W R T+ + LLEL V ++G + C A+NA G + ++ LS+ Sbjct: 292 RLSWTRGSLTLCPSRSSNPGLLELPRVHVRDEGEFTCRAQNAQGSQHISLSLSLQNEGTG 351 Query: 326 PWKPTVNGTMVAVEGETVSIL 346 +P T+ AV G + L Sbjct: 352 TSRPVSQVTLAAVGGAGATAL 372 Score = 50.8 bits (120), Expect = 4e-06 Identities = 33/109 (30%), Positives = 54/109 (49%), Gaps = 15/109 (13%) Query: 317 TVGLSVMYAPWKPTV--------------NGTMVAV-EGETVSILCSTQSNPDPILTIFK 361 TV L V Y PW T+ NG+ ++V EG+++ ++C+ SNP L+ + Sbjct: 238 TVRLDVSYPPWNLTMTVFQGDATASTALGNGSSLSVLEGQSLRLVCAVNSNPPARLSWTR 297 Query: 362 EKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVE 410 L + LELP V D+GE+ C A+N G + + +LS++ Sbjct: 298 GSLTLCPSRSSNPGLLELPRVHVRDEGEFTCRAQNAQGSQHISLSLSLQ 346 >gi|4502659 sialic acid binding Ig-like lectin 5 [Homo sapiens] Length = 551 Score = 121 bits (303), Expect = 2e-27 Identities = 111/435 (25%), Positives = 181/435 (41%), Gaps = 48/435 (11%) Query: 1 MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFP--DELRPAVVHGV 58 M+ L LPL W S + + S++ EG CV +PC F +P ++ Sbjct: 1 MLPLLLLPLLWGG-SLQEKPVYELQVQKSVTVQEGLCVLVPCSFSYPWRSWYSSPPLYVY 59 Query: 59 WYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFR 118 W+ + P V + + V QGR RLLGD+ +NC+L + + E G Y+FR Sbjct: 60 WFRDGEIPYYAEVVATNNPDRRVKPETQGRFRLLGDVQKKNCSLSIGDARMEDTGSYFFR 119 Query: 119 GDLGGYNQYTFSEH----SVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPEL-- 172 + G +Y++ ++ V ++ P+I + +G +SC +P +C E P L Sbjct: 120 VERGRDVKYSYQQNKLNLEVTALIEKPDIHFLEPLESGRPTRLSCSLPGSC-EAGPPLTF 178 Query: 173 SWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYA 232 SW G+ L + + S L P E +G L CQ + E Sbjct: 179 SWTGN----------ALSPLDPETTRSSELTLTPRPEDHGTNLTCQMKRQGAQVTTERTV 228 Query: 233 SMDVKYPP------------VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVL 280 ++V Y P I++ S + +EG + LLC A SNPP L+W + L Sbjct: 229 QLNVSYAPQTITIFRNGIALEILQNTSYLPVLEGQALRLLCDAPSNPPAHLSWFQGSPAL 288 Query: 281 REA-VAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVE 339 ++ + +LEL V AE+G + C A++ G + LSV P + G + E Sbjct: 289 NATPISNTGILELRRVRSAEEGGFTCRAQHPLGFLQIFLNLSVYSL---PQLLGPSCSWE 345 Query: 340 GETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSP------------EDD 387 E + CS ++ P P L E++ L + ++ + P D Sbjct: 346 AEGLHCRCSFRARPAPSLCWRLEEKPLEGNSSQGSFKVNSSSAGPWANSSLILHGGLSSD 405 Query: 388 GEYWCVAENQYGQRA 402 + C A N YG ++ Sbjct: 406 LKVSCKAWNIYGSQS 420 Score = 89.7 bits (221), Expect = 7e-18 Identities = 101/392 (25%), Positives = 161/392 (41%), Gaps = 33/392 (8%) Query: 258 SLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDGVYACLA-----ENAYG 312 SL ++ PP +W G L E+ +TP + L + A Sbjct: 165 SLPGSCEAGPPLTFSWT--GNALSPLDPETTRSSELTLTPRPEDHGTNLTCQMKRQGAQV 222 Query: 313 QDNRTVGLSVMYAPWKPTV--NGTMVAV----------EGETVSILCSTQSNPDPILTIF 360 RTV L+V YAP T+ NG + + EG+ + +LC SNP L+ F Sbjct: 223 TTERTVQLNVSYAPQTITIFRNGIALEILQNTSYLPVLEGQALRLLCDAPSNPPAHLSWF 282 Query: 361 KEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESH 420 + L+ + LEL V ++G + C A++ G NLSV P LL S Sbjct: 283 QGSPALNATPISNTGILELRRVRSAEEGGFTCRAQHPLGFLQIFLNLSVYSLPQLLGPS- 341 Query: 421 CAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREF-VYSERSGLVLTSILTLRGQ 479 C+ + + C C ++ P PS+ + L + + N S+ F V S +G S L L G Sbjct: 342 CSWEAEGLHCRCSFRARPAPSLCWRLEEKPLEGNSSQGSFKVNSSSAGPWANSSLILHGG 401 Query: 480 AQAPPRVICTARNLYGAKS-LELPFQGAHRL----MWAKIGPVGAVVAFAILIAIVCYIT 534 + +V C A N+YG++S L QG L + A +G G + I + ++ ++ Sbjct: 402 LSSDLKVSCKAWNIYGSQSGSVLLLQGRSNLGTGVVPAALGGAGVMALLCICLCLIFFLI 461 Query: 535 QTRRKKNVTESPSFSAGDNPPVL--FSSDFRISGAPEKYESERRLGSERRLLGLRGEPPE 592 R+K P D P++ +S R P+ + + L + E Sbjct: 462 VKARRKQAAGRPE-KMDDEDPIMGTITSGSRKKPWPDSPGDQASPPGDAPPLEEQKELHY 520 Query: 593 LDLSYSHSDLGKRPTKDSYTLTEELAEYAEIR 624 LS+ S++ R KD EY+EI+ Sbjct: 521 ASLSF--SEMKSREPKDQE--APSTTEYSEIK 548 >gi|23943856 sialic acid binding Ig-like lectin 9 [Homo sapiens] Length = 463 Score = 119 bits (298), Expect = 8e-27 Identities = 98/375 (26%), Positives = 159/375 (42%), Gaps = 41/375 (10%) Query: 2 IFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDE--LRPA-VVHGV 58 + L LPL W A M SS++ EG CV +PC F +P + P VVHG Sbjct: 1 MLLLLLPLLWGRERAEGQTSKLLTMQSSVTVQEGLCVHVPCSFSYPSHGWIYPGPVVHGY 60 Query: 59 WYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFR 118 W+ PV + + V E + R LLGD +NCTL + + G+Y+FR Sbjct: 61 WFREGANTDQDAPVATNNPARAVWEETRDRFHLLGDPHTKNCTLSIRDARRSDAGRYFFR 120 Query: 119 GDLGGYNQYTFSEH----SVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPE-LRPELS 173 + G ++ + H +V + + PNI++P + +G ++C VP C + P +S Sbjct: 121 MEKGSI-KWNYKHHRLSVNVTALTHRPNILIPGTLESGCPQNLTCSVPWACEQGTPPMIS 179 Query: 174 WLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYAS 233 W+G + + + + S+L +P + +G L CQ +FP ++ Sbjct: 180 WIGTS----------VSPLDPSTTRSSVLTLIPQPQDHGTSLTCQVTFPGASVTTNKTVH 229 Query: 234 MDVKYPP---------------VIVEMNSSVEAIEGSHVSLLC---GADSNPPP--LLTW 273 ++V YPP ++ SS+ EG + L+C DSNPP L+W Sbjct: 230 LNVSYPPQNLTMTVFQGDGTVSTVLGNGSSLSLPEGQSLRLVCAVDAVDSNPPARLSLSW 289 Query: 274 MRDGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNG 333 R T+ + +LEL V + + C A+N G + +S+ G Sbjct: 290 -RGLTLCPSQPSNPGVLELPWVHLRDAAEFTCRAQNPLGSQQVYLNVSLQSKATSGVTQG 348 Query: 334 TMVAVEGETVSILCS 348 +V G T + S Sbjct: 349 -VVGGAGATALVFLS 362 Score = 38.5 bits (88), Expect = 0.019 Identities = 40/168 (23%), Positives = 70/168 (41%), Gaps = 21/168 (12%) Query: 264 DSNPPPLLTWMRDG-TVLREAVAESLLLELEEVTPAEDGVYACLAE--NAYGQDNRTVGL 320 + PP+++W+ + L + S +L L C A N+TV L Sbjct: 171 EQGTPPMISWIGTSVSPLDPSTTRSSVLTLIPQPQDHGTSLTCQVTFPGASVTTNKTVHL 230 Query: 321 SVMYAPWKPTV--------------NGTMVAV-EGETVSILCSTQ---SNPDPILTIFKE 362 +V Y P T+ NG+ +++ EG+++ ++C+ SNP L++ Sbjct: 231 NVSYPPQNLTMTVFQGDGTVSTVLGNGSSLSLPEGQSLRLVCAVDAVDSNPPARLSLSWR 290 Query: 363 KQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVE 410 L + LELP V D E+ C A+N G + N+S++ Sbjct: 291 GLTLCPSQPSNPGVLELPWVHLRDAAEFTCRAQNPLGSQQVYLNVSLQ 338 >gi|16506826 sialic acid binding immunoglobulin-like lectin-like protein 1 isoform b precursor [Homo sapiens] Length = 477 Score = 118 bits (296), Expect = 1e-26 Identities = 95/385 (24%), Positives = 162/385 (42%), Gaps = 41/385 (10%) Query: 26 MPSSISAFEGTCVSIPCRFDFP--DELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHE 83 +P S++ EG CVS+PC +P + + V+G W+ PV + + V E Sbjct: 37 VPESVTVQEGLCVSVPCSVLYPHYNWTASSPVYGSWFKEGADIPWDIPVATNTPSGKVQE 96 Query: 84 SFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYN-QYTFSEHS--VLDIVNT 140 GR LLGD NC+L + + GKYYF+ + G Y + + S V + + Sbjct: 97 DTHGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVERGSRKWNYIYDKLSVHVTALTHM 156 Query: 141 PNIVVPPEVVAGTEVEVSCMVPDNCPE-LRPELSWLGHEGLGEPAVLGRLREDEGTWVQV 199 P +P + +G ++C VP C + P ++W+G + + T + Sbjct: 157 PTFSIPGTLESGHPRNLTCSVPWACEQGTPPTITWMG----------ASVSSLDPTITRS 206 Query: 200 SLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEM-------------- 245 S+L +P + +G L CQ + P + +++ YPP + M Sbjct: 207 SMLSLIPQPQDHGTSLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLR 266 Query: 246 -NSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESL-LLELEEVTPAEDGVY 303 S++ +EG + L+C DSNPP L+W L + + +L +LEL V ++G + Sbjct: 267 NGSALSVLEGQSLHLVCAVDSNPPARLSWTWGSLTLSPSQSSNLGVLELPRVHVKDEGEF 326 Query: 304 ACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEK 363 C A+N G + ++ LS+ + G M + G T+ +F Sbjct: 327 TCRAQNPLGSQHISLSLSL-----QNEYTGKMRPISGVTLGAF----GGAGATALVFLYF 377 Query: 364 QILSTVIYESELQLELPAVSPEDDG 388 I+ V+ + PAV D G Sbjct: 378 CIIFVVVRSCRKKSARPAVGVGDTG 402 Score = 49.3 bits (116), Expect = 1e-05 Identities = 44/166 (26%), Positives = 73/166 (43%), Gaps = 20/166 (12%) Query: 264 DSNPPPLLTWMRDG-TVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQD---NRTVG 319 + PP +TWM + L + S +L L P + G G R V Sbjct: 182 EQGTPPTITWMGASVSSLDPTITRSSMLSLIP-QPQDHGTSLTCQVTLPGAGVTMTRAVR 240 Query: 320 LSVMYAPWKPTV--------------NGTMVAV-EGETVSILCSTQSNPDPILTIFKEKQ 364 L++ Y P T+ NG+ ++V EG+++ ++C+ SNP L+ Sbjct: 241 LNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVCAVDSNPPARLSWTWGSL 300 Query: 365 ILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVE 410 LS + LELP V +D+GE+ C A+N G + + +LS++ Sbjct: 301 TLSPSQSSNLGVLELPRVHVKDEGEFTCRAQNPLGSQHISLSLSLQ 346 >gi|16506828 sialic acid binding immunoglobulin-like lectin-like protein 1 isoform a precursor [Homo sapiens] Length = 595 Score = 118 bits (296), Expect = 1e-26 Identities = 95/385 (24%), Positives = 162/385 (42%), Gaps = 41/385 (10%) Query: 26 MPSSISAFEGTCVSIPCRFDFP--DELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHE 83 +P S++ EG CVS+PC +P + + V+G W+ PV + + V E Sbjct: 155 VPESVTVQEGLCVSVPCSVLYPHYNWTASSPVYGSWFKEGADIPWDIPVATNTPSGKVQE 214 Query: 84 SFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYN-QYTFSEHS--VLDIVNT 140 GR LLGD NC+L + + GKYYF+ + G Y + + S V + + Sbjct: 215 DTHGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVERGSRKWNYIYDKLSVHVTALTHM 274 Query: 141 PNIVVPPEVVAGTEVEVSCMVPDNCPE-LRPELSWLGHEGLGEPAVLGRLREDEGTWVQV 199 P +P + +G ++C VP C + P ++W+G + + T + Sbjct: 275 PTFSIPGTLESGHPRNLTCSVPWACEQGTPPTITWMG----------ASVSSLDPTITRS 324 Query: 200 SLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEM-------------- 245 S+L +P + +G L CQ + P + +++ YPP + M Sbjct: 325 SMLSLIPQPQDHGTSLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLR 384 Query: 246 -NSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESL-LLELEEVTPAEDGVY 303 S++ +EG + L+C DSNPP L+W L + + +L +LEL V ++G + Sbjct: 385 NGSALSVLEGQSLHLVCAVDSNPPARLSWTWGSLTLSPSQSSNLGVLELPRVHVKDEGEF 444 Query: 304 ACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEK 363 C A+N G + ++ LS+ + G M + G T+ +F Sbjct: 445 TCRAQNPLGSQHISLSLSL-----QNEYTGKMRPISGVTLGAF----GGAGATALVFLYF 495 Query: 364 QILSTVIYESELQLELPAVSPEDDG 388 I+ V+ + PAV D G Sbjct: 496 CIIFVVVRSCRKKSARPAVGVGDTG 520 Score = 83.2 bits (204), Expect = 7e-16 Identities = 111/469 (23%), Positives = 180/469 (38%), Gaps = 66/469 (14%) Query: 1 MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAV--VHGV 58 ++ L PL + A + M S++ EG CVS+ C F +P A VHG Sbjct: 3 LLLLLLPPLLCGRVGAKEQKDYLLTMQKSVTVQEGLCVSVLCSFSYPQNGWTASDPVHGY 62 Query: 59 WYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFR 118 W+ + PV + + V E + R LLGD ++CTL + + G Y F Sbjct: 63 WFRAGDHVSRNIPVATNNPARAVQEETRDRFHLLGDPQNKDCTLSIRDTRESDAGTYVFC 122 Query: 119 GDLGG------YNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPEL 172 + G Y+Q + + + D+++ + VP V V+ V C L P Sbjct: 123 VERGNMKWNYKYDQLSVNVTASQDLLSRYRLEVPESVT----VQEGLCVSVPCSVLYPHY 178 Query: 173 SWLG---------HEGLGEP--------AVLGRLREDEGTWVQVSLLHFVPTREAN-GHR 214 +W EG P G+++ED T + LL T + R Sbjct: 179 NWTASSPVYGSWFKEGADIPWDIPVATNTPSGKVQED--THGRFLLLGDPQTNNCSLSIR 236 Query: 215 LGCQASFPNTTLQFE-GYASMDVKYPPVIVEMNSSVE--------AIEGSHV-SLLC--- 261 + Q E G + Y + V + + +E H +L C Sbjct: 237 DARKGDSGKYYFQVERGSRKWNYIYDKLSVHVTALTHMPTFSIPGTLESGHPRNLTCSVP 296 Query: 262 -GADSNPPPLLTWM-RDGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQD---NR 316 + PP +TWM + L + S +L L P + G G R Sbjct: 297 WACEQGTPPTITWMGASVSSLDPTITRSSMLSLIP-QPQDHGTSLTCQVTLPGAGVTMTR 355 Query: 317 TVGLSVMYAPWKPTV--------------NGTMVAV-EGETVSILCSTQSNPDPILTIFK 361 V L++ Y P T+ NG+ ++V EG+++ ++C+ SNP L+ Sbjct: 356 AVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVCAVDSNPPARLSWTW 415 Query: 362 EKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVE 410 LS + LELP V +D+GE+ C A+N G + + +LS++ Sbjct: 416 GSLTLSPSQSSNLGVLELPRVHVKDEGEFTCRAQNPLGSQHISLSLSLQ 464 >gi|193794821 sialic acid binding Ig-like lectin 6 isoform 1 precursor [Homo sapiens] Length = 453 Score = 115 bits (289), Expect = 9e-26 Identities = 102/363 (28%), Positives = 159/363 (43%), Gaps = 43/363 (11%) Query: 7 LPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVV-HGVWYFNSPY 65 LPL W A + P S++ EG CV +PCR P L + +G W+ Sbjct: 17 LPLLWAGALAQER-RFQLEGPESLTVQEGLCVLVPCRL--PTTLPASYYGYGYWFLEGAD 73 Query: 66 PKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYN 125 PV + V E +GR LL D +NC+L + + Y+FR Sbjct: 74 V----PVATNDPDEEVQEETRGRFHLLWDPRRKNCSLSIRDARRRDNAAYFFRLKSKWMK 129 Query: 126 Q-YTFSEHS--VLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPEL-SWLGHEGLG 181 YT S+ S V+ + + PNI +P + +G ++C VP C + P + SW+ Sbjct: 130 YGYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQGTPPIFSWMS----A 185 Query: 182 EPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP- 240 P LG Q S+L P + + L CQ +FP + E ++V Y P Sbjct: 186 APTSLG------PRTTQSSVLTITPRPQDHSTNLTCQVTFPGAGVTMERTIQLNVSYAPQ 239 Query: 241 --------------VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-VA 285 I++ SS+ +EG + LLC AD NPP L+W + L ++ Sbjct: 240 KVAISIFQGNSAAFKILQNTSSLPVLEGQALRLLCDADGNPPAHLSWFQGFPALNATPIS 299 Query: 286 ESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKP--TVNGTMVAVEGETV 343 + +LEL +V AE+G + C A++ G + + LS ++ WKP G + AV G ++ Sbjct: 300 NTGVLELPQVGSAEEGDFTCRAQHPLG--SLQISLS-LFVHWKPEGRAGGVLGAVWGASI 356 Query: 344 SIL 346 + L Sbjct: 357 TTL 359 Score = 50.8 bits (120), Expect = 4e-06 Identities = 50/210 (23%), Positives = 84/210 (40%), Gaps = 26/210 (12%) Query: 230 GYAS--MDVKYPPVIVEMNSSVEA-IEGSHVS-LLCGA----DSNPPPLLTWMRDG-TVL 280 GY S + V+ + N S+ +E H S L C + PP+ +WM T L Sbjct: 131 GYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQGTPPIFSWMSAAPTSL 190 Query: 281 REAVAESLLLELEEVTPAEDGVYACLAE--NAYGQDNRTVGLSVMYAPWKPTVN------ 332 +S +L + C A RT+ L+V YAP K ++ Sbjct: 191 GPRTTQSSVLTITPRPQDHSTNLTCQVTFPGAGVTMERTIQLNVSYAPQKVAISIFQGNS 250 Query: 333 ---------GTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVS 383 ++ +EG+ + +LC NP L+ F+ L+ + LELP V Sbjct: 251 AAFKILQNTSSLPVLEGQALRLLCDADGNPPAHLSWFQGFPALNATPISNTGVLELPQVG 310 Query: 384 PEDDGEYWCVAENQYGQRATAFNLSVEFAP 413 ++G++ C A++ G + +L V + P Sbjct: 311 SAEEGDFTCRAQHPLGSLQISLSLFVHWKP 340 >gi|157168355 CD22 molecule [Homo sapiens] Length = 847 Score = 115 bits (288), Expect = 1e-25 Identities = 130/465 (27%), Positives = 198/465 (42%), Gaps = 38/465 (8%) Query: 14 ISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPD-ELRPAVVHGVWYFNSPYPKNYPPV 72 ++ S W P ++ A+EG CV IPC + D +L ++ + N Y KN Sbjct: 16 LAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFIL----FHNPEYNKNTSKF 71 Query: 73 ----VFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYNQYT 128 +++S S Q R + LGD +NCTL + V G+ R + Sbjct: 72 DGTRLYESTKDGKVPSEQKRVQFLGDKN-KNCTLSIHPVHLNDSGQLGLRMESKTEKWME 130 Query: 129 FSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEG--LGEPAVL 186 +V + P+I +PPE+ EV ++C++ +C +L WL EG + + AV Sbjct: 131 RIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWL-LEGVPMRQAAVT 189 Query: 187 GRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMN 246 + + + S L F P +G + CQ + ++VK+ P + Sbjct: 190 STSLTIKSVFTR-SELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKV 248 Query: 247 SSVEAI--EGSHVSLLCGADSNPPPLLT--WMRDGTVLREAVAESLLLELEEVTPAEDGV 302 + +AI EG V++ C S+ P T W++DGT L++ + L L EVT + G Sbjct: 249 TPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKK--QNTFTLNLREVTKDQSGK 306 Query: 303 YACLAENAYGQD-NRTVGLSVMYAPWKPTVNGT-MVAVEGETVSILCSTQSNPDPILTIF 360 Y C N G + V L V YAP TV AVEG V LC + +NP P T + Sbjct: 307 YCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLP--TNY 364 Query: 361 KEKQILSTVIYESELQLELPAVSPEDDGEYWCVAEN--QYGQRATAFNLSVEFAP----V 414 + +E ++ +P + P G Y CVAEN GQR L V++ P Sbjct: 365 TWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTT 424 Query: 415 LLLESHCAAARDTVQCLC-VVKSNP-------EPSVAFELPSRNV 451 ++ DTV C SNP +P A+E PS V Sbjct: 425 VIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGV 469 Score = 68.2 bits (165), Expect = 2e-11 Identities = 90/324 (27%), Positives = 136/324 (41%), Gaps = 34/324 (10%) Query: 101 TLLLSNVSPELGGKYYFR--GDLG-GYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEV 157 TL L V+ + GKY + D+G G ++ F + +T I+ P V G++VE Sbjct: 293 TLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSP-AVEGSQVEF 351 Query: 158 SCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGC 217 CM N L +W H G + GR E +H + C Sbjct: 352 LCMSLAN--PLPTNYTWY-HNG---KEMQGRTEEK---------VHIPKILPWHAGTYSC 396 Query: 218 QASFPNTTLQFEGYASMDVKYPP--VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLT--W 273 A T Q A +DV+YPP V + + + EG V+L C +S+ P + W Sbjct: 397 VAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEW 456 Query: 274 MRDGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNG 333 G ++ +L+++ V ++ AC A N++ V L+V YAP V Sbjct: 457 KPHGAWEEPSLG---VLKIQNVG-WDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRK 512 Query: 334 TMVAVE---GETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEY 390 E G +VS+ C S+ + F EK + + E QL ++SPED G Y Sbjct: 513 IKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEK---NGRLLGKESQLNFDSISPEDAGSY 569 Query: 391 WCVAENQYGQRAT-AFNLSVEFAP 413 C N GQ A+ A+ L V +AP Sbjct: 570 SCWVNNSIGQTASKAWTLEVLYAP 593 Score = 65.5 bits (158), Expect = 1e-10 Identities = 68/278 (24%), Positives = 119/278 (42%), Gaps = 35/278 (12%) Query: 146 PPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFV 205 P + G V +SC + P + W H EP+ LG L+ W ++ Sbjct: 429 PMPIREGDTVTLSCNYNSSNPSVT-RYEWKPHGAWEEPS-LGVLKIQNVGWDNTTI---- 482 Query: 206 PTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIE---GSHVSLLCG 262 C A N+ + +++V+Y P V + E G+ VSL C Sbjct: 483 ----------ACAAC--NSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCD 530 Query: 263 ADSNPPPLLT--WMRDGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQD-NRTVG 319 S+ P + W ++G +L + L + ++P + G Y+C N+ GQ ++ Sbjct: 531 FSSSHPKEVQFFWEKNGRLL----GKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWT 586 Query: 320 LSVMYAPWKPTVN---GTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQ 376 L V+YAP + V+ G V +EG++ ++ C + +NP + + S + +L+ Sbjct: 587 LEVLYAPRRLRVSMSPGDQV-MEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLR 645 Query: 377 LELPAVSPEDDGEYWCVAENQYGQ-RATAFNLSVEFAP 413 LE V + G YWC N G+ R+ L+V ++P Sbjct: 646 LE--PVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSP 681 Score = 40.0 bits (92), Expect = 0.006 Identities = 34/118 (28%), Positives = 52/118 (44%), Gaps = 8/118 (6%) Query: 233 SMDVKYPP--VIVEMNSSVEAIEGSHVSLLCGADSNPP-PLLTWMRDGTVLREAVAESLL 289 +++V Y P + V M+ + +EG +L C +D+NPP TW + S Sbjct: 586 TLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNN--QSLPYHSQK 643 Query: 290 LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVE-GETVSIL 346 L LE V G Y C N+ G+ + +Y + P G VAV G ++IL Sbjct: 644 LRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVY--YSPETIGRRVAVGLGSCLAIL 699 >gi|193794819 sialic acid binding Ig-like lectin 6 isoform 2 precursor [Homo sapiens] Length = 437 Score = 114 bits (285), Expect = 3e-25 Identities = 100/348 (28%), Positives = 157/348 (45%), Gaps = 29/348 (8%) Query: 7 LPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVV-HGVWYFNSPY 65 LPL W A + P S++ EG CV +PCR P L + +G W+ Sbjct: 17 LPLLWAGALAQER-RFQLEGPESLTVQEGLCVLVPCRL--PTTLPASYYGYGYWFLEGAD 73 Query: 66 PKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYN 125 PV + V E +GR LL D +NC+L + + Y+FR Sbjct: 74 V----PVATNDPDEEVQEETRGRFHLLWDPRRKNCSLSIRDARRRDNAAYFFRLKSKWMK 129 Query: 126 Q-YTFSEHS--VLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPEL-SWLGHEGLG 181 YT S+ S V+ + + PNI +P + +G ++C VP C + P + SW+ Sbjct: 130 YGYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQGTPPIFSWMS----A 185 Query: 182 EPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPV 241 P LG Q S+L P + + L CQ +FP + E ++V Sbjct: 186 APTSLG------PRTTQSSVLTITPRPQDHSTNLTCQVTFPGAGVTMERTIQLNVS-SFK 238 Query: 242 IVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-VAESLLLELEEVTPAED 300 I++ SS+ +EG + LLC AD NPP L+W + L ++ + +LEL +V AE+ Sbjct: 239 ILQNTSSLPVLEGQALRLLCDADGNPPAHLSWFQGFPALNATPISNTGVLELPQVGSAEE 298 Query: 301 GVYACLAENAYGQDNRTVGLSVMYAPWKP--TVNGTMVAVEGETVSIL 346 G + C A++ G + + LS ++ WKP G + AV G +++ L Sbjct: 299 GDFTCRAQHPLG--SLQISLS-LFVHWKPEGRAGGVLGAVWGASITTL 343 Score = 45.1 bits (105), Expect = 2e-04 Identities = 49/196 (25%), Positives = 82/196 (41%), Gaps = 14/196 (7%) Query: 230 GYAS--MDVKYPPVIVEMNSSVEA-IEGSHVS-LLCGA----DSNPPPLLTWMRDG-TVL 280 GY S + V+ + N S+ +E H S L C + PP+ +WM T L Sbjct: 131 GYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQGTPPIFSWMSAAPTSL 190 Query: 281 REAVAESLLLELEEVTPAEDGVYACLAE--NAYGQDNRTVGLSVMYAPWKPTVNGTMVAV 338 +S +L + C A RT+ L+V + +K N + + V Sbjct: 191 GPRTTQSSVLTITPRPQDHSTNLTCQVTFPGAGVTMERTIQLNV--SSFKILQNTSSLPV 248 Query: 339 -EGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQ 397 EG+ + +LC NP L+ F+ L+ + LELP V ++G++ C A++ Sbjct: 249 LEGQALRLLCDADGNPPAHLSWFQGFPALNATPISNTGVLELPQVGSAEEGDFTCRAQHP 308 Query: 398 YGQRATAFNLSVEFAP 413 G + +L V + P Sbjct: 309 LGSLQISLSLFVHWKP 324 >gi|148762980 sialic acid binding Ig-like lectin 14 [Homo sapiens] Length = 396 Score = 110 bits (274), Expect = 5e-24 Identities = 93/348 (26%), Positives = 145/348 (41%), Gaps = 38/348 (10%) Query: 1 MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFP--DELRPAVVHGV 58 M+ L LPL W S + + S++ EG CV +PC F +P ++ Sbjct: 1 MLPLLLLPLLWGG-SLQEKPVYELQVQKSVTVQEGLCVLVPCSFSYPWRSWYSSPPLYVY 59 Query: 59 WYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFR 118 W+ + P V + + V QGR RLLGD+ +NC+L + + E G Y+FR Sbjct: 60 WFRDGEIPYYAEVVATNNPDRRVKPETQGRFRLLGDVQKKNCSLSIGDARMEDTGSYFFR 119 Query: 119 GDLGGYNQYTFSEH----SVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPEL-- 172 + G +Y++ ++ V ++ P+I + +G +SC +P +C E P L Sbjct: 120 VERGRDVKYSYQQNKLNLEVTALIEKPDIHFLEPLESGRPTRLSCSLPGSC-EAGPPLTF 178 Query: 173 SWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYA 232 SW G+ L + + S L P E +G L CQ + E Sbjct: 179 SWTGN----------ALSPLDPETTRSSELTLTPRPEDHGTNLTCQVKRQGAQVTTERTV 228 Query: 233 SMDVKYPPV-----------------IVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMR 275 ++V Y P I+ SV EG + L C DSNPP L+W R Sbjct: 229 QLNVSYAPQNLAISIFFRNGTGTALRILSNGMSVPIQEGQSLFLACTVDSNPPASLSWFR 288 Query: 276 DGTVLREA-VAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSV 322 +G L + + S LEL + E G + C ++ G + + LSV Sbjct: 289 EGKALNPSQTSMSGTLELPNIGAREGGEFTCRVQHPLGSQHLSFILSV 336 Score = 52.4 bits (124), Expect = 1e-06 Identities = 50/200 (25%), Positives = 80/200 (40%), Gaps = 38/200 (19%) Query: 258 SLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDGVYACLA-----ENAYG 312 SL ++ PP +W G L E+ +TP + L + A Sbjct: 165 SLPGSCEAGPPLTFSWT--GNALSPLDPETTRSSELTLTPRPEDHGTNLTCQVKRQGAQV 222 Query: 313 QDNRTVGLSVMYAPWKPTV-----NGTMVAV------------EGETVSILCSTQSNPDP 355 RTV L+V YAP + NGT A+ EG+++ + C+ SNP Sbjct: 223 TTERTVQLNVSYAPQNLAISIFFRNGTGTALRILSNGMSVPIQEGQSLFLACTVDSNPPA 282 Query: 356 ILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL 415 L+ F+E + L+ LELP + + GE+ C ++ G + +F LSV+ Sbjct: 283 SLSWFREGKALNPSQTSMSGTLELPNIGAREGGEFTCRVQHPLGSQHLSFILSVQ----- 337 Query: 416 LLESHCAAARDTVQCLCVVK 435 R + C+CV + Sbjct: 338 ---------RSSSSCICVTE 348 >gi|193794817 sialic acid binding Ig-like lectin 6 isoform 3 precursor [Homo sapiens] Length = 353 Score = 109 bits (272), Expect = 9e-24 Identities = 94/340 (27%), Positives = 147/340 (43%), Gaps = 38/340 (11%) Query: 7 LPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVV-HGVWYFNSPY 65 LPL W A + P S++ EG CV +PCR P L + +G W+ Sbjct: 17 LPLLWAGALAQER-RFQLEGPESLTVQEGLCVLVPCRL--PTTLPASYYGYGYWFLEGAD 73 Query: 66 PKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYN 125 PV + V E +GR LL D +NC+L + + Y+FR Sbjct: 74 V----PVATNDPDEEVQEETRGRFHLLWDPRRKNCSLSIRDARRRDNAAYFFRLKSKWMK 129 Query: 126 Q-YTFSEHS--VLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPEL-SWLGHEGLG 181 YT S+ S V+ + + PNI +P + +G ++C VP C + P + SW+ Sbjct: 130 YGYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQGTPPIFSWMS----A 185 Query: 182 EPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP- 240 P LG Q S+L P + + L CQ +FP + E ++V Y P Sbjct: 186 APTSLG------PRTTQSSVLTITPRPQDHSTNLTCQVTFPGAGVTMERTIQLNVSYAPQ 239 Query: 241 --------------VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-VA 285 I++ SS+ +EG + LLC AD NPP L+W + L ++ Sbjct: 240 KVAISIFQGNSAAFKILQNTSSLPVLEGQALRLLCDADGNPPAHLSWFQGFPALNATPIS 299 Query: 286 ESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYA 325 + +LEL +V AE+G + C A++ G ++ L V ++ Sbjct: 300 NTGVLELPQVGSAEEGDFTCRAQHPLGSLQISLSLFVHWS 339 Score = 50.1 bits (118), Expect = 6e-06 Identities = 50/217 (23%), Positives = 87/217 (40%), Gaps = 26/217 (11%) Query: 230 GYAS--MDVKYPPVIVEMNSSVEA-IEGSHVS-LLCGA----DSNPPPLLTWMRDG-TVL 280 GY S + V+ + N S+ +E H S L C + PP+ +WM T L Sbjct: 131 GYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQGTPPIFSWMSAAPTSL 190 Query: 281 REAVAESLLLELEEVTPAEDGVYACLAE--NAYGQDNRTVGLSVMYAPWKPTVN------ 332 +S +L + C A RT+ L+V YAP K ++ Sbjct: 191 GPRTTQSSVLTITPRPQDHSTNLTCQVTFPGAGVTMERTIQLNVSYAPQKVAISIFQGNS 250 Query: 333 ---------GTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVS 383 ++ +EG+ + +LC NP L+ F+ L+ + LELP V Sbjct: 251 AAFKILQNTSSLPVLEGQALRLLCDADGNPPAHLSWFQGFPALNATPISNTGVLELPQVG 310 Query: 384 PEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESH 420 ++G++ C A++ G + +L V ++ + + H Sbjct: 311 SAEEGDFTCRAQHPLGSLQISLSLFVHWSSAPVPDRH 347 >gi|118572606 hemicentin 1 [Homo sapiens] Length = 5635 Score = 99.0 bits (245), Expect = 1e-20 Identities = 106/388 (27%), Positives = 162/388 (41%), Gaps = 48/388 (12%) Query: 142 NIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGL-----GEPAV---LGRLRE-D 192 NI VPP + E+ ++ N L E S + L G P + +GR+R Sbjct: 2190 NIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILS 2249 Query: 193 EGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAI 252 G +Q+S+ +++ C AS T + E ++ V P I S I Sbjct: 2250 GGRQLQISI-----AEKSDAALYSCVASNVAGTAKKE--YNLQVYIRPTITNSGSHPTEI 2302 Query: 253 ---EGSHVSLLCGADSNPPPLLTWMRDGTVLREA-----VAESLLLELEEVTPAEDGVYA 304 G +SL C PPP +TWM+DG L +A + E +L+L+ + ++ G Y Sbjct: 2303 IVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYV 2362 Query: 305 CLAENAYGQDNRTVGLSVMYAPWKPTVNG------TMVAVEGETVSILCSTQSNPDPILT 358 C+A N G ++ LSV +AP P++ G + VE +VS+ C P P +T Sbjct: 2363 CVAVNVAGMTDKKYDLSV-HAP--PSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSIT 2419 Query: 359 IFKEKQIL----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPV 414 FK+ + S I L L + ED G+Y CV N G+ F LSV P Sbjct: 2420 WFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPH 2479 Query: 415 LL----LESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVL 470 ++ LE + +V C V NP P + + + + E E + S L + Sbjct: 2480 IVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQ--PLQEDEAHHIISGGRFLQI 2537 Query: 471 TSILTLRGQAQAPPRVICTARNLYGAKS 498 T++ Q R C A + G KS Sbjct: 2538 TNV-----QVPHTGRYTCLASSPAGHKS 2560 Score = 94.0 bits (232), Expect = 4e-19 Identities = 95/367 (25%), Positives = 163/367 (44%), Gaps = 47/367 (12%) Query: 142 NIVVPPEVVAGTEVEVSCMVPDNCPELR--------PELSWLGHEGLGEPAVLGR--LRE 191 N+ VPP V+ G + E +V +N L P+LSWL +E +P L L Sbjct: 2959 NVHVPPSVI-GPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNE---QPIKLNTNTLIV 3014 Query: 192 DEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSS--- 248 G +Q+ + + ++G C A N + + S+ V PP I + +S Sbjct: 3015 PGGRTLQI-----IRAKVSDGGEYTCIAI--NQAGESKKKFSLTVYVPPSIKDHDSESLS 3067 Query: 249 -VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-----VAESLLLELEEVTPAEDGV 302 V EG+ VSL C +++ PPP++TW ++G ++ E+ +A+ +L +++ ++ G Sbjct: 3068 VVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQ 3127 Query: 303 YACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVS----ILCSTQSNPDPILT 358 Y C A N G+D++ L+V Y P P++ G V ET+S + C P P + Sbjct: 3128 YVCRAINVAGRDDKNFHLNV-YVP--PSIEGPEREVIVETISNPVTLTCDATGIPPPTIA 3184 Query: 359 IFK-EKQI-----LSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFA 412 K K+I L I +L++ D G Y C+A N G+ + LS++ Sbjct: 3185 WLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVP 3244 Query: 413 PVL----LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGL 468 P + + + V+ +C P P + + + + E+ER V + S L Sbjct: 3245 PSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTL 3304 Query: 469 VLTSILT 475 + LT Sbjct: 3305 NIYGALT 3311 Score = 91.7 bits (226), Expect = 2e-18 Identities = 88/366 (24%), Positives = 141/366 (38%), Gaps = 37/366 (10%) Query: 149 VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTR 208 V+AG EV + C V P P ++W L P T++ + TR Sbjct: 1091 VLAGEEVTLPCEVKSLPP---PIITWAKETQLISPF------SPRHTFLPSGSMKITETR 1141 Query: 209 EANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPP 268 ++ C A+ N ++V PP I ++ G V + C A P Sbjct: 1142 TSDSGMYLCVAT--NIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPL 1199 Query: 269 PLLTWMRDGTVL-----REAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVM 323 P++TW + G+ + L +++ TP++ G+Y C+A N G D + L V Sbjct: 1200 PVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQ 1259 Query: 324 YAPW----KPTVNGTMVA-VEGETVSILCSTQSNPDPILTIFKEKQILS-----TVIYES 373 P +P N T V + + C + P P + + L+ I E Sbjct: 1260 EPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILED 1319 Query: 374 ELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL----LLESHCAAARDTVQ 429 L + +V+P D+GEY CVA N+ G +NL V PV+ + + Sbjct: 1320 GTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTN 1379 Query: 430 CLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQAQAPPRVICT 489 C V+ P P + + NV V ES + + +G +L R + R C Sbjct: 1380 LFCEVEGTPSPIIMWY--KDNVQVTESST--IQTVNNGKILK---LFRATPEDAGRYSCK 1432 Query: 490 ARNLYG 495 A N+ G Sbjct: 1433 AINIAG 1438 Score = 85.5 bits (210), Expect = 1e-16 Identities = 91/370 (24%), Positives = 156/370 (42%), Gaps = 46/370 (12%) Query: 70 PPVVFKSRTQVVHESFQGRSRLLG-------DLGLRNCTLLLSNVSPELGGKYYFRGDLG 122 P +++K + V GR R+L + ++ L S V+ + G Sbjct: 2226 PNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKE---- 2281 Query: 123 GYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGE 182 YN + ++ + + P ++ V G + + C V P P ++W+ G Sbjct: 2282 -YNLQVYIRPTITNSGSHPTEII---VTRGKSISLECEVQGIPP---PTVTWMKD---GH 2331 Query: 183 PAVLGRLRE--DEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP 240 P + + E DEG +Q+ +H T R C A N + + V PP Sbjct: 2332 PLIKAKGVEILDEGHILQLKNIHVSDTG-----RYVCVAV--NVAGMTDKKYDLSVHAPP 2384 Query: 241 VIVEMNSSVE---AIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-----LEL 292 I+ + S E +E + VSL C A P P +TW +DG + + + +L L L Sbjct: 2385 SIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRILSGGRMLRL 2444 Query: 293 EEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPW---KPTVNGTMVAVEGETVSILCST 349 + T + G Y C+ NA G++ + GLSV+ P + T+ V E ++V++ C Sbjct: 2445 MQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVK-EKQSVTLTCEV 2503 Query: 350 QSNPDPILTIFKEKQILSTV----IYESELQLELPAVSPEDDGEYWCVAENQYGQRATAF 405 NP P +T K+ Q L I L++ V G Y C+A + G ++ +F Sbjct: 2504 TGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSF 2563 Query: 406 NLSVEFAPVL 415 +L+V +P + Sbjct: 2564 SLNVFVSPTI 2573 Score = 85.1 bits (209), Expect = 2e-16 Identities = 72/272 (26%), Positives = 110/272 (40%), Gaps = 13/272 (4%) Query: 234 MDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVL----REAVAESLL 289 + V+ PP + M + GS VS++C A P P + W + + R + Sbjct: 606 LTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGT 665 Query: 290 LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCST 349 L ++ P + G+Y CLA N+ G D + L + AP V ++ G+ + C T Sbjct: 666 LFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGDITVMECKT 725 Query: 350 QSNPDPILTIFKEKQIL--STVIYESEL--QLELPAVSPEDDGEYWCVAENQYGQRATAF 405 P P + FK L ST + L L++ D G+Y CVA N+ G+ Sbjct: 726 SGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKI 785 Query: 406 NLSVEFAPVLLLESHCAAAR--DTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYS 463 L V PV + E + V C V+ PEP++ + R + R F S Sbjct: 786 TLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWR---RLDNMPIFSRPFSVS 842 Query: 464 ERSGLVLTSILTLRGQAQAPPRVICTARNLYG 495 S L ++ L A IC A N +G Sbjct: 843 SISQLRTGALFILNLWASDKGTYICEAENQFG 874 Score = 83.6 bits (205), Expect = 5e-16 Identities = 99/409 (24%), Positives = 163/409 (39%), Gaps = 59/409 (14%) Query: 59 WYFNSPYPKNYPPVVFKSRTQVVH-ESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYF 117 WY ++ + F +R Q++ ES Q + D G+ C + S + EL Sbjct: 1954 WYKDNRLLSGSTSMTFLNRGQIIDIESAQ-----ISDAGIYKCVAINSAGATELF----- 2003 Query: 118 RGDLGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGH 177 Y+ H I + N+V VV V + C P P L+WL Sbjct: 2004 ---------YSLQVHVAPSISGSNNMVA---VVVNNPVRLECEAR-GIPA--PSLTWL-K 2047 Query: 178 EGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVK 237 +G + L+ G +L + ++ R C A N + + + V Sbjct: 2048 DGSPVSSFSNGLQVLSGG----RILALTSAQISDTGRYTCVAV--NAAGEKQRDIDLRVY 2101 Query: 238 YPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESL-----LLEL 292 PP I+ +V + V LLC +D+ PPP LTW++DG L + S+ +L++ Sbjct: 2102 VPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKI 2161 Query: 293 EEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGT-----MVAVEGETVSILC 347 E+ + G Y C A N G+ + +++ + P P + G+ + +EG +S+LC Sbjct: 2162 EDAQVQDTGRYTCEATNVAGKTEKNYNVNI-WVP--PNIGGSDELTQLTVIEGNLISLLC 2218 Query: 348 STQSNPDPILTIFKEK-------QILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQ 400 + P P L I+K+K + I QL++ D Y CVA N G Sbjct: 2219 ESSGIPPPNL-IWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGT 2277 Query: 401 RATAFNLSVEFAPVLLLE-SH----CAAARDTVQCLCVVKSNPEPSVAF 444 +NL V P + SH ++ C V+ P P+V + Sbjct: 2278 AKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTW 2326 Score = 80.9 bits (198), Expect = 3e-15 Identities = 98/422 (23%), Positives = 163/422 (38%), Gaps = 55/422 (13%) Query: 101 TLLLSNVSPELGGKYYFRGDLGGYNQYTFSEHSVLDIVNTPNIVVPPE---VVAGTEVEV 157 TL + N +P+ G Y G L + T ++S L + P ++V V G + Sbjct: 665 TLFIKNAAPKDAGIY---GCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGDITVM 721 Query: 158 SCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVS----LLHFVPTREANGH 213 C P P++ W G L T++ + LL T++ + Sbjct: 722 ECKTSGIPP---PQVKWFK----------GDLELRPSTFLIIDPLLGLLKIQETQDLDAG 768 Query: 214 RLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTW 273 C A N + G ++DV PPV ++ + V GS+V+L C P P + W Sbjct: 769 DYTCVAI--NEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKW 826 Query: 274 MR--DGTVLREAVAESLLLELE-------EVTPAEDGVYACLAENAYG--QDNRTVGLSV 322 R + + + S + +L + ++ G Y C AEN +G Q TV ++ Sbjct: 827 RRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTG 886 Query: 323 MYAPWKPTVNGTMVAVEGETVSILCSTQS-NPDPILTIFKEKQILSTVIY---ESELQLE 378 + AP +EG+ +++ C+ + NP P K +L Y S+ L Sbjct: 887 LVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLH 946 Query: 379 LPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAAARDTVQCL-----CV 433 + V +D GEY CVA N G ++ V P + H T++ + C Sbjct: 947 IERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTI---QHGQQILSTIEGIPVTLPCK 1003 Query: 434 VKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQAQAPPRVICTARNL 493 NP+PSV + + ++ S +F L + S + +CTA N Sbjct: 1004 ASGNPKPSVIWS--KKGELISTSSAKFSAGADGSLYVVS-----PGGEESGEYVCTATNT 1056 Query: 494 YG 495 G Sbjct: 1057 AG 1058 Score = 79.7 bits (195), Expect = 7e-15 Identities = 59/223 (26%), Positives = 100/223 (44%), Gaps = 12/223 (5%) Query: 231 YASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVL-----REAVA 285 + ++ V PPVI S + I + + L C A P P +TW ++G + AV Sbjct: 3979 HVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVL 4038 Query: 286 ESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAP-WKPTVNGTMVAVEGETVS 344 S L++ + G Y C+A+N G + L+V P P + ++AV+ + ++ Sbjct: 4039 PSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVD-KPIT 4097 Query: 345 ILCSTQSNPDPILTIFKEKQILSTVIYESEL---QLELPAVSPEDDGEYWCVAENQYGQR 401 + C P P +T K+ + + I + L L++ V P D G Y C+A N G Sbjct: 4098 LSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSS 4157 Query: 402 ATAFNLSVEFAP-VLLLESHCAAARDTVQCL-CVVKSNPEPSV 442 +T+ L+V P + E H ++ L CV P P++ Sbjct: 4158 STSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAI 4200 Score = 79.7 bits (195), Expect = 7e-15 Identities = 66/238 (27%), Positives = 96/238 (40%), Gaps = 14/238 (5%) Query: 234 MDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL---- 289 + V PP I E S L C AD P P + W +D +L + + Sbjct: 4163 LTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYG 4222 Query: 290 -LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCS 348 L LE V + G Y C+A NA G+D TV L+V P + G + +GE + + C Sbjct: 4223 ELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCK 4282 Query: 349 TQSNPDPILTIFKEKQIL----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATA 404 P P LT I+ +V SEL +E VS ED G Y C AEN G Sbjct: 4283 ATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIE--RVSKEDSGTYVCTAENSVGFVKAI 4340 Query: 405 FNLSVEFAPVL---LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESERE 459 + V+ PV + C VK +P P++ + ++ ++ R+ Sbjct: 4341 GFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQ 4398 Score = 77.0 bits (188), Expect = 5e-14 Identities = 100/397 (25%), Positives = 151/397 (38%), Gaps = 66/397 (16%) Query: 93 GDLGLRNCTLLLSNVSPELGG-KYYFRGDL--GGYNQYTFSEHS------VLDIVNTPNI 143 GDL LR T L+ + P LG K DL G Y +E LD+ + P Sbjct: 738 GDLELRPSTFLI--IDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVF 795 Query: 144 VVPPEVVA---GTEVEVSCMVP------------DNCPEL-RP-ELSWLGHEGLGEPAVL 186 + P V+ G+ V + C V DN P RP +S + G +L Sbjct: 796 IQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFIL 855 Query: 187 GRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMN 246 D+GT++ C+A +Q E ++ P+I Sbjct: 856 NLWASDKGTYI-------------------CEAENQFGKIQSETTVTVTGLVAPLIGISP 896 Query: 247 SSVEAIEGSHVSLLCGA-DSNPPPLLTWMRDGTVLRE----AVAESLLLELEEVTPAEDG 301 S IEG ++L C NP P W+++ +L + V L +E V + G Sbjct: 897 SVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQLQDGG 956 Query: 302 VYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFK 361 Y C+A N G +N+T + V P + +EG V++ C NP P + K Sbjct: 957 EYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSK 1016 Query: 362 EKQILST--VIYESELQLELPAVSP--EDDGEYWCVAENQYGQRATAFNLSVEFAPVLLL 417 + +++ST + + L VSP E+ GEY C A N G L+V P + Sbjct: 1017 KGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFG 1076 Query: 418 ESH----------CAAARDTVQCLCVVKSNPEPSVAF 444 + A + V C VKS P P + + Sbjct: 1077 DQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITW 1113 Score = 76.3 bits (186), Expect = 8e-14 Identities = 94/408 (23%), Positives = 161/408 (39%), Gaps = 43/408 (10%) Query: 120 DLGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPEL--------RPE 171 D G Y S +I +++VPP + G E ++ +N EL P Sbjct: 1706 DRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPT 1765 Query: 172 LSWLGHEGLGEPAVLGRLREDEGTWVQVS--LLHFVPTREANGHRLGCQASFPNTTLQFE 229 + WL L + E +G + ++ L + +N C A+ NT + Sbjct: 1766 IMWLKDGQL--------IDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAA--NTAGDHK 1815 Query: 230 GYASMDVKYPPVIVEMNSSVE-AIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA----- 283 + V PP I S ++ V+L C A+ P P +TW++D + A Sbjct: 1816 KEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLK 1875 Query: 284 -VAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTM--VAVEG 340 + +L++ + + G Y C+A NA G+ + + L V P + + Sbjct: 1876 IQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVS 1935 Query: 341 ETVSILCSTQSNPDPILTIFKEKQILS-----TVIYESELQLELPAVSPEDDGEYWCVAE 395 V + C NP P++T +K+ ++LS T + ++ +++ + D G Y CVA Sbjct: 1936 NPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQI-IDIESAQISDAGIYKCVAI 1994 Query: 396 NQYGQRATAFNLSVEFAPVLLLESHCAA--ARDTVQCLCVVKSNPEPSVAFELPSRNVTV 453 N G ++L V AP + ++ A + V+ C + P PS+ + L + Sbjct: 1995 NSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTW-LKDGSPVS 2053 Query: 454 NESEREFVYSERSGLVLTSILTLRGQAQAPPRVICTARNLYGAKSLEL 501 + S V S L LTS Q R C A N G K ++ Sbjct: 2054 SFSNGLQVLSGGRILALTS-----AQISDTGRYTCVAVNAAGEKQRDI 2096 Score = 76.3 bits (186), Expect = 8e-14 Identities = 63/260 (24%), Positives = 110/260 (42%), Gaps = 20/260 (7%) Query: 201 LLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVE--AIEGSHVS 258 +L T + R C A+ N + + + + V PP + + + + + V Sbjct: 1882 VLQIAKTLLEDAGRYTCVAT--NAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQ 1939 Query: 259 LLCGADSNPPPLLTWMRDGTVLREAVAESLL-----LELEEVTPAEDGVYACLAENAYGQ 313 L C A NP P++TW +D +L + + + L +++E ++ G+Y C+A N+ G Sbjct: 1940 LECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGA 1999 Query: 314 DNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYES 373 L V AP N + V V + C + P P LT K+ +S+ + + Sbjct: 2000 TELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSS--FSN 2057 Query: 374 ELQ-------LELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAAA-- 424 LQ L L + D G Y CVA N G++ +L V P ++ E + Sbjct: 2058 GLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLI 2117 Query: 425 RDTVQCLCVVKSNPEPSVAF 444 V+ LC + P P++ + Sbjct: 2118 SQAVELLCQSDAIPPPTLTW 2137 Score = 75.5 bits (184), Expect = 1e-13 Identities = 78/339 (23%), Positives = 133/339 (39%), Gaps = 51/339 (15%) Query: 142 NIVVPPEVVAGTEVEVSCMVPDNCPELR--------PELSWLGHEGLGEPAVLGRLREDE 193 N+ VPP + G E EV N L P ++WL + R+ + Sbjct: 3146 NVYVPPSI-EGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHK--------RIENSD 3196 Query: 194 GTWVQV----SLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIV--EMNS 247 V++ S L ++ ++ C AS N + + Y + ++ PP + E+ S Sbjct: 3197 SLEVRILSGGSKLQIARSQHSDSGNYTCIAS--NMEGKAQKYYFLSIQVPPSVAGAEIPS 3254 Query: 248 SVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESL-------LLELEEVTPAED 300 V + G +V L+C A+ P PL+ W++DG + E + L + ++ Sbjct: 3255 DVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDT 3314 Query: 301 GVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGT------MVAVEGETVSILCSTQSNPD 354 G Y C+A N G+++R L+V PT+ G ++ + +++I C P Sbjct: 3315 GKYTCVATNPAGEEDRIFNLNVYVT---PTIRGNKDEAEKLMTLVDTSINIECRATGTPP 3371 Query: 355 PILTIFKEKQILSTVIYESELQ----LELPAVSPEDDGEYWCVAENQYGQRATAFNLSVE 410 P + K L + L + + D Y CVA N+ G +NL V Sbjct: 3372 PQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQV- 3430 Query: 411 FAPVLL-----LESHCAAARDTVQCLCVVKSNPEPSVAF 444 FAP + E + C+ P PS+A+ Sbjct: 3431 FAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAW 3469 Score = 75.1 bits (183), Expect = 2e-13 Identities = 59/226 (26%), Positives = 96/226 (42%), Gaps = 22/226 (9%) Query: 249 VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVL-----REAVAESLLLELEEVTPAEDGVY 303 + + G V+L C S PPP++TW ++ ++ R S +++ E ++ G+Y Sbjct: 1089 ISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMY 1148 Query: 304 ACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEK 363 C+A N G + V L+V P + G+ V I C+ Q P P++T K Sbjct: 1149 LCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGG 1208 Query: 364 QILSTVIYESELQ-------LELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL 416 ST++ + E L + +P D G Y CVA N G T L V+ P + Sbjct: 1209 ---STMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVE 1265 Query: 417 -LES------HCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNE 455 LE A ++ C K P+P++ + R +T E Sbjct: 1266 DLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGRE 1311 Score = 75.1 bits (183), Expect = 2e-13 Identities = 73/330 (22%), Positives = 138/330 (41%), Gaps = 44/330 (13%) Query: 202 LHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMN--------SSVEAIE 253 L + +E N R C A+ N + + + V PP+I + + V+ Sbjct: 2631 LQILNAQEDNAGRYSCVAT--NEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKV 2688 Query: 254 GSHVSLLCGADSNPPPLLTWMRDGTVLRE-----AVAESLLLELEEVTPAEDGVYACLAE 308 + ++L C A + P L+W +DG L+ A L+++E ++ G Y C+A Sbjct: 2689 NNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVAS 2748 Query: 309 NAYGQDNRTVGLSVMYAP--WKPTVNGTMV----------AVEGETVSILCSTQSNPDPI 356 N G+D +++ P K G M+ + +S+ C T + P P Sbjct: 2749 NIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPT 2808 Query: 357 LTIFKEKQILST----VIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFA 412 LT +K+ L++ +I L++P ED G Y CVA N+ G+ + +++ V Sbjct: 2809 LTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVP 2868 Query: 413 PVL------LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERS 466 P++ L E + C+ +P P +++ + + + + +F+ + R Sbjct: 2869 PIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPL-LEDDHHKFLSNGRI 2927 Query: 467 GLVLTSILTLRGQAQAPPRVICTARNLYGA 496 +L + +T G R +C A N G+ Sbjct: 2928 LQILNTQITDIG------RYVCVAENTAGS 2951 Score = 71.6 bits (174), Expect = 2e-12 Identities = 61/235 (25%), Positives = 93/235 (39%), Gaps = 29/235 (12%) Query: 233 SMDVKYPPVIVEMNSSV-----EAIEGSHVSLLCGADSNPPPLLTWMRDGTVLR------ 281 ++ V+ PP + ++ E + + C A P P + W+ +G L Sbjct: 1255 TLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGI 1314 Query: 282 EAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPW---KPTVNGTMVAV 338 + + LL + VTP ++G Y C+A N G R L V P K V V + Sbjct: 1315 SILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLL 1374 Query: 339 EGETVSILCSTQSNPDPILTIFK------EKQILSTVIYESELQLELPAVSPEDDGEYWC 392 + ++ C + P PI+ +K E + TV + L+L +PED G Y C Sbjct: 1375 N-QLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTV--NNGKILKLFRATPEDAGRYSC 1431 Query: 393 VAENQYGQRATAFNLSVEFAPVLL-----LESHCAAARDTVQCLCVVKSNPEPSV 442 A N G FN+ V P ++ E RD V C VK P P + Sbjct: 1432 KAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRD-VALECQVKGTPFPDI 1485 Score = 68.9 bits (167), Expect = 1e-11 Identities = 63/280 (22%), Positives = 114/280 (40%), Gaps = 19/280 (6%) Query: 233 SMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLR---EAVAESLL 289 S+ V P E+ V +G + L C A P P LTW + ++ ++V Sbjct: 4253 SLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSE 4312 Query: 290 LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAP--WKPTVNGTMVAVEGETVSILC 347 L +E V+ + G Y C AEN+ G + +G + P +K + G + C Sbjct: 4313 LVIERVSKEDSGTYVCTAENSVGFV-KAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNC 4371 Query: 348 STQSNPDPILTIFKEK---QILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATA 404 + +P P + ++ +I + L + ED G+Y CVA N+ G + Sbjct: 4372 EVKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERS 4431 Query: 405 FNLSVEFAPVLLLE--SHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVY 462 +L+++ P++ LE A + C P+P++ + +++ + +R V Sbjct: 4432 MSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWD--DRVNVL 4489 Query: 463 SERSGLVLTSILTLRGQAQAPPRVICTARNLYGAKSLELP 502 S S+ Q + C ARNL G+ + +P Sbjct: 4490 SN------NSLYIADAQKEDTSEFECVARNLMGSVLVRVP 4523 Score = 68.6 bits (166), Expect = 2e-11 Identities = 69/285 (24%), Positives = 115/285 (40%), Gaps = 34/285 (11%) Query: 148 EVVAGTEVEVSCMVPDNCPELRPELSWL--GHEGLGEPAVLGRLREDEGTWVQVSLLHFV 205 E VA +E C +P + WL G E G + L ++GT + ++ + Sbjct: 1277 ERVANQRIEFPCPAKGTP---KPTIKWLHNGRELTGREPGISIL--EDGTLLVIASV--- 1328 Query: 206 PTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIV--EMNSSVEAIEGSHVSLLCGA 263 T NG + + TT E ++ V PPVI E ++V + +L C Sbjct: 1329 -TPYDNGEYICVAVNEAGTT---ERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEV 1384 Query: 264 DSNPPPLLTWMRDGTVLREA-----VAESLLLELEEVTPAEDGVYACLAENAYGQDNRTV 318 + P P++ W +D + E+ V +L+L TP + G Y+C A N G + Sbjct: 1385 EGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYF 1444 Query: 319 GLSVMYAPWKPTVNGT-----MVAVEGETVSILCSTQSNPDPILTIFKEKQIL-----ST 368 + V+ P T+ GT + V V++ C + P P + FK+ + L + Sbjct: 1445 NIDVLVPP---TIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNV 1501 Query: 369 VIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAP 413 + + L L D G Y C N G++A L++ P Sbjct: 1502 ELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPP 1546 Score = 68.2 bits (165), Expect = 2e-11 Identities = 78/309 (25%), Positives = 130/309 (42%), Gaps = 52/309 (16%) Query: 142 NIVVPPEVVAGTEVE-----------VSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLR 190 +++VPP +V +E ++C V N PE++W H+ G+P L+ Sbjct: 2473 SVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPV---PEITW--HKD-GQP-----LQ 2521 Query: 191 EDEGTWVQVS--LLHFVPTREANGHRLGCQASFP--NTTLQFEGYASMDVKYPPVIVEMN 246 EDE + L + + R C AS P + + F S++V P I + Sbjct: 2522 EDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSF----SLNVFVSPTIAGVG 2577 Query: 247 SS-----VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-----LELEEVT 296 S V I S SL+C A S PP +TW +DGT L +L L++ Sbjct: 2578 SDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQ 2637 Query: 297 PAEDGVYACLAENAYGQDNRTVGLSVMYAP-------WKPTVNGTMVAVE-GETVSILCS 348 G Y+C+A N G+ + + V P W P ++ V ++ T+++ C Sbjct: 2638 EDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECE 2697 Query: 349 TQSNPDPILTIFKEKQILST----VIYESELQLELPAVSPEDDGEYWCVAENQYGQRATA 404 + P L+ +K+ Q L + I + L++ D G Y CVA N G+ Sbjct: 2698 AYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELD 2757 Query: 405 FNLSVEFAP 413 F+++++ P Sbjct: 2758 FDVNIQVPP 2766 Score = 68.2 bits (165), Expect = 2e-11 Identities = 79/363 (21%), Positives = 146/363 (40%), Gaps = 33/363 (9%) Query: 130 SEHSVLDIVNTPNIVVPPE-----VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPA 184 S+H +L ++ P+I E V+ +E++C + P P+++W+ +G P Sbjct: 3516 SKHFILKVLEPPHINGSEEHEEISVIVNNPLELTC-IASGIPA--PKMTWM-KDGRPLPQ 3571 Query: 185 VLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVE 244 G +++S T R C AS P E + V PP I Sbjct: 3572 TDQVQTLGGGEVLRISTAQVEDTG-----RYTCLASSPAGDDDKEYLVRVHV--PPNIAG 3624 Query: 245 MNS--SVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-----LELEEVTP 297 + + + V+L C +D+ PPP++TW+R+G L+ +L L++ Sbjct: 3625 TDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRILSGGRYLQINNADL 3684 Query: 298 AEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPIL 357 + Y C+A N G+ R L+V P ++V + ++ + C + P P + Sbjct: 3685 GDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRI 3744 Query: 358 TIFKEKQILS------TVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEF 411 T K+ +L+ +++ L ++ V+ D G Y C+A N G +L V Sbjct: 3745 TWRKDGAVLAGNHARYSILENGFLHIQSAHVT--DTGRYLCMATNAAGTDRRRIDLQVHV 3802 Query: 412 APVLLLESHCAAARDTVQ--CLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLV 469 P + VQ C P+PS+ + + V++++ + LV Sbjct: 3803 PPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLV 3862 Query: 470 LTS 472 + S Sbjct: 3863 IIS 3865 Score = 67.0 bits (162), Expect = 5e-11 Identities = 54/221 (24%), Positives = 93/221 (42%), Gaps = 16/221 (7%) Query: 250 EAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-----LELEEVTPAEDGVYA 304 + I + +SL C ++ PPP LTW +DG L + +L L++ + G Y Sbjct: 2788 DVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYT 2847 Query: 305 CLAENAYGQDNRTVGLSVMYAPWKPTVNGTM----VAVEGETVSILCSTQSNPDPILTIF 360 C+A N G+D+ + V+ P N + + ++ I C + +P P + Sbjct: 2848 CVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQ 2907 Query: 361 KEKQILSTVIYESELQ----LELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL 416 K+ Q L + L L++ D G Y CVAEN G FNL+V P ++ Sbjct: 2908 KDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVI 2967 Query: 417 ---LESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVN 454 E+ + + C V P P +++ + + +N Sbjct: 2968 GPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLN 3008 Score = 67.0 bits (162), Expect = 5e-11 Identities = 56/227 (24%), Positives = 87/227 (38%), Gaps = 23/227 (10%) Query: 234 MDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVL-----REAVAESL 288 + V PP I S+ + L C A+ P P +TW +DG VL R ++ E+ Sbjct: 3707 LTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENG 3766 Query: 289 LLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCS 348 L ++ + G Y C+A NA G D R + L V P M + ++ C Sbjct: 3767 FLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACE 3826 Query: 349 TQSNPDPILTIFKEKQILSTVIYESELQL----ELPAVSP--EDDGEYWCVAENQYGQRA 402 P P + K +L+ ++ +L L +SP +D Y C N G Sbjct: 3827 ATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDK 3886 Query: 403 TAFNLSVEFAPVL-------LLESHCAAARDTVQCLCVVKSNPEPSV 442 +L+V+ P + L+ H A C P PS+ Sbjct: 3887 RTVDLTVQVPPSIADEPTDFLVTKHAPAV-----ITCTASGVPFPSI 3928 Score = 64.7 bits (156), Expect = 2e-10 Identities = 84/382 (21%), Positives = 144/382 (37%), Gaps = 47/382 (12%) Query: 143 IVVPPEVVAGT-----EVEVSCMVPDNCPELR----PELSWLGHEGLGEPAVLGR--LRE 191 I +PP + G V ++ ++ C E R P ++W G+P + L Sbjct: 1542 IYIPPSIKGGNVTTDISVLINSLIKLEC-ETRGLPMPAITWYKD---GQPIMSSSQALYI 1597 Query: 192 DEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSV-- 249 D+G + LH + ++ C + N E +DV PP+I E N + Sbjct: 1598 DKGQY-----LHIPRAQVSDSATYTCHVA--NVAGTAEKSFHVDVYVPPMI-EGNLATPL 1649 Query: 250 --EAIEGSHVSLLCGADSNPPPLLTWMRDGTVLR-----EAVAESLLLELEEVTPAEDGV 302 + + ++L C A NP P+LTW++DG ++ A LE+ + G Sbjct: 1650 NKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQ 1709 Query: 303 YACLAENAYGQDNRTVGLSVMYAPWKPTVNGT--MVAVEGETVSILCSTQSNPDPILTIF 360 Y C+A + G+ + V+ P + T + + + + C +P P + Sbjct: 1710 YICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWL 1769 Query: 361 KEKQILST----VIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL 416 K+ Q++ I + +L + + G Y C+A N G F ++V P + Sbjct: 1770 KDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIK 1829 Query: 417 ---LESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSI 473 L V C+ P PS+ + + V + + + SG VL Sbjct: 1830 SSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKI---QSSGRVLQIA 1886 Query: 474 LTLRGQAQAPPRVICTARNLYG 495 TL A R C A N G Sbjct: 1887 KTLLEDA---GRYTCVATNAAG 1905 Score = 61.6 bits (148), Expect = 2e-09 Identities = 59/219 (26%), Positives = 86/219 (39%), Gaps = 11/219 (5%) Query: 235 DVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA------VAESL 288 DV PP ++++ ++V G L C S LTW R+ +R A +L Sbjct: 515 DVSEPPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANL 574 Query: 289 LLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCS 348 LEL+ V + G Y C+ + G +V L+V P + G VSI+CS Sbjct: 575 SLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCS 634 Query: 349 TQSNPDP-ILTIFKEKQILSTVIYE--SELQLELPAVSPEDDGEYWCVAENQYGQRATAF 405 P P I + I+ + Y S+ L + +P+D G Y C+A N G Sbjct: 635 ATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNS 694 Query: 406 NLSVEFAPVLLL--ESHCAAARDTVQCLCVVKSNPEPSV 442 L AP L++ A D C P P V Sbjct: 695 TLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQV 733 Score = 58.2 bits (139), Expect = 2e-08 Identities = 42/179 (23%), Positives = 72/179 (40%), Gaps = 17/179 (9%) Query: 249 VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVL-----REAVAESLLLELEEVTPAEDGVY 303 + ++GS S+ C D P P + W+RDG L ++L+L + + G Y Sbjct: 3445 ITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKY 3504 Query: 304 ACLAENAYGQDNRTVGLSVMYAPWKPTVNGT-----MVAVEGETVSILCSTQSNPDPILT 358 C+A N G+ ++ L V+ P +NG+ + + + + C P P +T Sbjct: 3505 TCIASNEAGEVSKHFILKVLE---PPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMT 3561 Query: 359 IFKEKQILSTVIYESEL----QLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAP 413 K+ + L L L + ED G Y C+A + G + + V P Sbjct: 3562 WMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPP 3620 Score = 57.0 bits (136), Expect = 5e-08 Identities = 47/195 (24%), Positives = 85/195 (43%), Gaps = 11/195 (5%) Query: 261 CGADSNPPPLLTWMRDGTVLRE----AVAESLLLELEEVTPAEDGVYACLAENAYGQDNR 316 C DS P L+++R+G L + S+ L++ +VT +++G Y C+A ++ G Sbjct: 451 CSVDSLLPFTLSFVRNGVTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRA 510 Query: 317 TVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQIL-----STVIY 371 V P V + GE + C S D LT + + + + + Sbjct: 511 QTFFDVSEPPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRT 570 Query: 372 ESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAP--VLLLESHCAAARDTVQ 429 + L LEL +V D GEY C+ ++ G A + L+V+ P ++ ++ V Sbjct: 571 LANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVS 630 Query: 430 CLCVVKSNPEPSVAF 444 +C P+P +A+ Sbjct: 631 IMCSATGYPKPKIAW 645 Score = 54.7 bits (130), Expect = 3e-07 Identities = 63/276 (22%), Positives = 96/276 (34%), Gaps = 22/276 (7%) Query: 234 MDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELE 293 + V PP I +++ I +L C A P P + W ++G +L ++ L Sbjct: 3798 LQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLS 3857 Query: 294 E-----VTPAED--GVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSIL 346 ++P+ D Y C N G D RTV L+V P + + I Sbjct: 3858 SGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVIT 3917 Query: 347 CSTQSNPDPILTIFKEKQIL----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRA 402 C+ P P + K L S +E+ A G Y CVA N G Sbjct: 3918 CTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAH 3977 Query: 403 TAFNLSVEFAPVLL---LESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESERE 459 L V PV+ E H + + C P P + ++ + VN S R Sbjct: 3978 RHVTLHVHEPPVIQPQPSELH-VILNNPILLPCEATGTPSPFITWQ--KEGINVNTSGRN 4034 Query: 460 FVYSERSGLVLTSILTLRGQAQAPPRVICTARNLYG 495 GL ++ R + +C A+N G Sbjct: 4035 HAVLPSGGLQIS-----RAVREDAGTYMCVAQNPAG 4065 >gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] Length = 3874 Score = 95.9 bits (237), Expect = 1e-19 Identities = 93/353 (26%), Positives = 155/353 (43%), Gaps = 33/353 (9%) Query: 131 EHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLR 190 +H L + +P + P VV E + + RP ++W EGL + Sbjct: 2747 KHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQ-KEGLNVATGVSTQV 2805 Query: 191 EDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVE 250 G Q+ + H P E G+ L C A N+ G + V+ PPVI + Sbjct: 2806 LPGG---QLRIAHASP--EDAGNYL-CIAK--NSAGSAMGKTRLVVQVPPVIENGLPDLS 2857 Query: 251 AIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-----VAESLLLELEEVTPAEDGVYAC 305 EGSH L C A +P P +TW +DG + A + S L ++ + + G Y C Sbjct: 2858 TTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTC 2917 Query: 306 LAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQI 365 AENA G+ R V L+++ P T+ G G+ + + C+ + +P P + + Sbjct: 2918 TAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRP 2977 Query: 366 LSTVIYESE--LQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAA 423 ++ + E + L+ AVS ED G Y C AEN+ G+ + V+ APVL E+ Sbjct: 2978 VTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYL 3037 Query: 424 AR---DTVQCLCVVKSNPEPSVAF--------------ELPSRNVTVNESERE 459 ++Q CVV+ +P P + + +L + ++T++ +ER+ Sbjct: 3038 VEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERD 3090 Score = 92.0 bits (227), Expect = 1e-18 Identities = 93/329 (28%), Positives = 138/329 (41%), Gaps = 35/329 (10%) Query: 143 IVVPPEVVAGTE-------VEVSCMVPDNCPELR---PELSWLGHEGLGEPAVLGRLRED 192 ++ PP ++ TE V S V CP L P +SWL + P+ ++ ED Sbjct: 1647 VLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLED 1706 Query: 193 EGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMN-SSVEA 251 G +QVS A+ C A N E ++ V+ PP I ++ V A Sbjct: 1707 -GQVLQVSTAEV-----ADAASYMCVAE--NQAGSAEKLFTLRVQVPPRIAGLDLEQVTA 1758 Query: 252 IEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-----LELEEVTPAEDGVYACL 306 I S VSL C ++P P +TW +D L LL L+L ++ G+Y C Sbjct: 1759 ILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCE 1818 Query: 307 AENAYGQDNRTVGLSVMYAP-WKPTVNGTMVAV---EGETVSILCSTQSNPDPILTIFKE 362 A NA G+D + V LSV+ P ++ G AV G+ + C T + P+P +T +K+ Sbjct: 1819 ALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKD 1878 Query: 363 KQIL----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL--- 415 Q L T +LE+ D G Y C N G+ F L+V+ P Sbjct: 1879 GQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENP 1938 Query: 416 LLESHCAAARDTVQCLCVVKSNPEPSVAF 444 E+ A + C V P P+V + Sbjct: 1939 KTETVSQVAGSPLVLTCDVSGVPAPTVTW 1967 Score = 83.2 bits (204), Expect = 7e-16 Identities = 70/270 (25%), Positives = 112/270 (41%), Gaps = 17/270 (6%) Query: 236 VKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-----VAESLLL 290 V PP I + + + V L C + P P ++W + G L V+ S L Sbjct: 2662 VHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGAL 2721 Query: 291 ELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQ 350 E+ + P G Y C A N+ G ++ V L+V +P + + AV E V + C Sbjct: 2722 EIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEAS 2781 Query: 351 SNPDPILTIFKEKQILSTVIYESEL---QLELPAVSPEDDGEYWCVAENQYGQRATAFNL 407 P P +T KE ++T + L QL + SPED G Y C+A+N G L Sbjct: 2782 GIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRL 2841 Query: 408 SVEFAPVLL--LESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSER 465 V+ PV+ L C + +PEP++ ++ + V+ +E +F Sbjct: 2842 VVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQ--PVSGAEGKFTIQPS 2899 Query: 466 SGLVLTSILTLRGQAQAPPRVICTARNLYG 495 L++ ++ + Q CTA N G Sbjct: 2900 GELLVKNL-----EGQDAGTYTCTAENAVG 2924 Score = 81.6 bits (200), Expect = 2e-15 Identities = 93/419 (22%), Positives = 163/419 (38%), Gaps = 51/419 (12%) Query: 142 NIVVPPEVVAGTEVEVSCMVPDNCPELR---------PELSWLGHEGLGEPAVLGRLRED 192 +++VPPE++ + + + P P + W E EP G ED Sbjct: 1154 SVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGE---EPVSPG---ED 1207 Query: 193 EGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIV--EMNSSVE 250 +L T+E + C AS N + S++V PP I ++ ++ Sbjct: 1208 TYLLAGGWMLKMTQTQEQDSGLYSCLAS--NEAGEARRNFSVEVLVPPSIENEDLEEVIK 1265 Query: 251 AIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVA-----ESLLLELEEVTPAEDGVYAC 305 ++G L+C +P P LTW +DG L A + +LL++ + + G Y+C Sbjct: 1266 VLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSC 1325 Query: 306 LAENAYGQDNRTVGLSVMYAPW-----KPTVNGTMVAVEGETVSILCSTQSNPDPILTIF 360 +A NA G+ + LSV+ AP + + + + +S++C + P P +T Sbjct: 1326 IAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWM 1385 Query: 361 KE----KQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL 416 K+ + + + L++ ED G+Y CV N+ G+ +++ V P + Sbjct: 1386 KDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSIS 1445 Query: 417 LESHC---------AAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSG 467 + T+ C + P P++ + + VT S R V E Sbjct: 1446 KDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVT--PSSRLQVLGEGRL 1503 Query: 468 LVLTSILTLRGQAQAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAIL 526 L + Q R +C A N+ G + M+ K+G A AF IL Sbjct: 1504 LQIQPT-----QVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSA--AFEIL 1555 Score = 80.9 bits (198), Expect = 3e-15 Identities = 70/286 (24%), Positives = 117/286 (40%), Gaps = 30/286 (10%) Query: 234 MDVKYPPVIV---EMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL- 289 ++V PP I E + V ++ +L C A PPP +TW RDG + + L Sbjct: 1059 LEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQN 1118 Query: 290 ----LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAP-----WKPTVNGTMVAVEG 340 L +E A G Y+C+AEN G+ R LSV+ P P N + A Sbjct: 1119 QGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTN--ITAALH 1176 Query: 341 ETVSILCSTQSNPDPILTIFKEKQILS----TVIYESELQLELPAVSPEDDGEYWCVAEN 396 +++LC P P + F+ ++ +S T + L++ +D G Y C+A N Sbjct: 1177 SPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASN 1236 Query: 397 QYGQRATAFNLSVEFAPVL----LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVT 452 + G+ F++ V P + L E T +C V +P+P + + R + Sbjct: 1237 EAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLA 1296 Query: 453 VNESEREFVYSERSGLVLTSILTLRGQAQAPPRVICTARNLYGAKS 498 ++ + G++L L+ + C A N G K+ Sbjct: 1297 RGDAH----HISPDGVLLQ---VLQANLSSAGHYSCIAANAVGEKT 1335 Score = 80.1 bits (196), Expect = 6e-15 Identities = 87/368 (23%), Positives = 153/368 (41%), Gaps = 42/368 (11%) Query: 149 VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSL----LHF 204 V+ G EV + C P P+++WL G P L +D G ++ L L Sbjct: 2038 VLEGQEVRLDCEADGQPP---PDVAWLKD---GSP-----LGQDMGPHLRFYLDGGSLVL 2086 Query: 205 VPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVI---VEMNSSVEAIEGSHVSLLC 261 R ++ C A N + +++V PP I + + ++ + G V+++C Sbjct: 2087 KGLRASDAGAYTCVAH--NPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVC 2144 Query: 262 GADSNPPPLLTWMRDGTVLREAVAESL-----LLELEEVTPAEDGVYACLAENAYGQDNR 316 +PP ++W++DG L + L L + +V A+ G++ C+A + G +R Sbjct: 2145 PVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADR 2204 Query: 317 TVGLSVMYAPWKPTVN--GTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESE 374 L V P V +V V G V + C + P P+++ K+ + L + E Sbjct: 2205 NFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQG 2264 Query: 375 LQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAAARDT----VQC 430 L+L AV D G Y CVA ++ G+ F L+V P + T ++ Sbjct: 2265 PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMEL 2324 Query: 431 LCVVKSNPEPSVAFELPSRNVT--VNESEREFVYSERSGLVLTSIL---------TLRGQ 479 LC + P+P++ + + +T N S V R + T + + R + Sbjct: 2325 LCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVR 2384 Query: 480 AQAPPRVI 487 QAPP ++ Sbjct: 2385 VQAPPNIV 2392 Score = 79.7 bits (195), Expect = 7e-15 Identities = 60/225 (26%), Positives = 96/225 (42%), Gaps = 35/225 (15%) Query: 255 SHVSLLCGADSNPPPLLTWMRDGTVLR-----EAVAESLLLELEEVTPAEDGVYACLAEN 309 S ++L C + + PPP + W +DG + + + E LL+++ ++ G Y C+A N Sbjct: 1464 STLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATN 1523 Query: 310 AYGQDNRTVGLSVMYAPWKPTVNGTMVA--------------------VEGETVSILCST 349 G+D++ + + P V A VE + C T Sbjct: 1524 VAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDT 1583 Query: 350 QSNPDPILTIFKEKQILSTVIYESELQ----LELPAVSPEDDGEYWCVAENQYGQRATAF 405 + P P LT ++E Q LS S LQ L++P V E+ G Y C A N+ G+ + Sbjct: 1584 NAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHY 1643 Query: 406 NLSVEFAPVL------LLESHCAAARDTVQCLCVVKSNPEPSVAF 444 L V PV+ L+E A TV C NP P++++ Sbjct: 1644 ELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISW 1688 Score = 77.0 bits (188), Expect = 5e-14 Identities = 94/383 (24%), Positives = 143/383 (37%), Gaps = 51/383 (13%) Query: 141 PNIVVPPE----VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTW 196 P I +PP V+ T V ++C P P L WL PA L+ G Sbjct: 786 PRITLPPSLPGPVLVNTPVRLTCNAT-GAPS--PTLMWLKDGNPVSPAGTPGLQVFPGGR 842 Query: 197 VQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSH 256 V L R ++ R C A + + + V PP I+ +V + Sbjct: 843 V----LTLASARASDSGRYSCVAV--SAVGEDRQDVVLQVHMPPSILGEELNVSVVANES 896 Query: 257 VSLLCGADSNPPPLLTWMRDGTVLR-----EAVAESLLLELEEVTPAEDGVYACLAENAY 311 V+L C + + PPP+L+W +DG L A+ LL+++ + G Y C A N Sbjct: 897 VALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQA 956 Query: 312 GQDNRTVGLSVMYAPWKP-TVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQIL---- 366 G+ + L+V AP P + T+ EG S+ C + P P ++ K+ Q L Sbjct: 957 GRSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEG 1016 Query: 367 ---------STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL- 416 ++Y + QL +G Y C N G + L V P + Sbjct: 1017 AGLQHVSAVGRLLYLGQAQL-------AQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAG 1069 Query: 417 ---LESHCAAARDTVQCL-CVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTS 472 + + +D V L C P P+V +E + V + + G S Sbjct: 1070 PREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELG----LQLQNQG---QS 1122 Query: 473 ILTLRGQAQAPPRVICTARNLYG 495 + R QA R C A NL G Sbjct: 1123 LHVERAQAAHTGRYSCVAENLAG 1145 Score = 75.5 bits (184), Expect = 1e-13 Identities = 86/332 (25%), Positives = 125/332 (37%), Gaps = 38/332 (11%) Query: 172 LSWLGHE-GLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTL---- 226 L W G+ LG V G DEG LHF + R G QA T Sbjct: 141 LGWAGYGWDLGWGQVGGHRLLDEG-----QSLHFPRIQPGRSGRRGAQAGGSAQTKAPWX 195 Query: 227 -------QFEGYASMDVKYPPVIVEMNSSVEAI--EGSHVSLLCGADSNPPPLLTWMRD- 276 QF + PP ++ ++ E + G+ V L C P P + W +D Sbjct: 196 AGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDR 255 Query: 277 -----GTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAP--WKP 329 G + + +L + ++G Y C+A + GQ R L V P W Sbjct: 256 QPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGS 315 Query: 330 TVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILST---VIY-ESELQLELPAVSPE 385 G + +E V +LC + P P +T FK+ +L T V+Y QL+L Sbjct: 316 NETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSS 375 Query: 386 DDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESH-----CAAARDTVQCLCVVKSNPEP 440 D G Y C A N G A L V P + A A V CV + +P P Sbjct: 376 DAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSP 435 Query: 441 SVAFELPSRNVTVNESEREFVYSERSGLVLTS 472 ++++ + V ES + ++ S L L S Sbjct: 436 TLSWH--HEGLPVAESNESRLETDGSVLRLES 465 Score = 72.8 bits (177), Expect = 9e-13 Identities = 63/224 (28%), Positives = 92/224 (41%), Gaps = 20/224 (8%) Query: 250 EAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-----LELEEVTPAEDGVYA 304 E +E + L C ++ PPP LTW R+ L S+L L++ V G Y+ Sbjct: 1570 EIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYS 1629 Query: 305 CLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVE------GETVSILCSTQSNPDPILT 358 C A N G+D L V+ P + T VE TVS+ C NP P ++ Sbjct: 1630 CKASNEVGEDWLHYELLVLTPP--VILGDTEELVEEVTVNASSTVSLQCPALGNPVPTIS 1687 Query: 359 IFKEKQILS----TVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPV 414 + S + E L++ D Y CVAENQ G F L V+ P Sbjct: 1688 WLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPR 1747 Query: 415 LL---LESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNE 455 + LE A +V C V ++P P V + S+ +++ E Sbjct: 1748 IAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGE 1791 Score = 72.4 bits (176), Expect = 1e-12 Identities = 63/229 (27%), Positives = 97/229 (42%), Gaps = 26/229 (11%) Query: 236 VKYPPVIVEMNSS--VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-----VAESL 288 V PP I N + V +E V LLC A P P +TW +DG +L + Sbjct: 306 VHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGR 365 Query: 289 LLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNG------TMVAVEGET 342 L+L ++ GVY C A NA G + L V Y P PT+ G + AV G Sbjct: 366 QLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV-YVP--PTIEGAGGRPYVVKAVAGRP 422 Query: 343 VSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGE-----YWCVAENQ 397 V++ C + +P P L+ + + + ES L+ + + E GE Y CVA + Sbjct: 423 VALECVARGHPSPTLS-WHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSP 481 Query: 398 YGQRATAFNLSVEFAPVLLLESHCAAARDTV----QCLCVVKSNPEPSV 442 G+ +++ V+ P LL+ V + C +P P++ Sbjct: 482 AGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTI 530 Score = 72.4 bits (176), Expect = 1e-12 Identities = 95/381 (24%), Positives = 143/381 (37%), Gaps = 53/381 (13%) Query: 134 VLDIVNTPNIVVPPEVVAGTEVEVSCM---VPDNCPELRPELSWLGHEGLGEPAVLGRLR 190 VL+ V N VV VV G+ VE+ C VP P +SW+ GEP + L Sbjct: 2215 VLEPVEFQNDVV---VVRGSLVELPCEARGVP------LPLVSWMKD---GEPLLSQSLE 2262 Query: 191 EDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYA----SMDVKYPPVIVEMN 246 + P+ + G ++ + G A + V PP I + Sbjct: 2263 QG-------------PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSG 2309 Query: 247 SSVEA--IEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDGVYA 304 E G+ + LLC A P P +TW +DG L S + V A G+Y Sbjct: 2310 QPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDA--GLYT 2367 Query: 305 CLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAV---EGETVSILCSTQSNPDPILTIFK 361 CLAE+ G ++ + V P G V G+ V + CS ++ P P +T + Sbjct: 2368 CLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLV-LECSVEAEPAPKITWHR 2426 Query: 362 EKQILS----TVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLL 417 + +L T E L+L A+S D G+Y C A N G + AF + + P + Sbjct: 2427 DGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRS 2486 Query: 418 ESHC--AAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILT 475 + T C P P V++ V ++ F L + +L Sbjct: 2487 GPPAVNVSVNQTALLPCQADGVPAPLVSWR--KDRVPLDPRSPRFEILPEGSLRIQPVL- 2543 Query: 476 LRGQAQAPPRVICTARNLYGA 496 AQ +C A N G+ Sbjct: 2544 ----AQDAGHYLCLASNSAGS 2560 Score = 69.7 bits (169), Expect = 8e-12 Identities = 50/200 (25%), Positives = 86/200 (43%), Gaps = 20/200 (10%) Query: 233 SMDVKYPPVIVEMNS-SVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-- 289 ++ V+ PP + +V + GS + L C P P +TW++D + + ++ Sbjct: 1926 TLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSR 1985 Query: 290 ---LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVA-----VEGE 341 L+L + PA+ G Y C+AEN + + ++V+ A P + + VA +EG+ Sbjct: 1986 GGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVA---PRIRSSGVAREHHVLEGQ 2042 Query: 342 TVSILCSTQSNPDPILTIFKEKQILSTVI------YESELQLELPAVSPEDDGEYWCVAE 395 V + C P P + K+ L + Y L L + D G Y CVA Sbjct: 2043 EVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAH 2102 Query: 396 NQYGQRATAFNLSVEFAPVL 415 N G+ A ++V P + Sbjct: 2103 NPAGEDARLHTVNVLVPPTI 2122 Score = 65.9 bits (159), Expect = 1e-10 Identities = 64/291 (21%), Positives = 117/291 (40%), Gaps = 27/291 (9%) Query: 141 PNIVVP--PEVVAGT---EVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGT 195 PNIV P P V G ++ + C V E P+++W +G+ + G Sbjct: 2389 PNIVGPRGPRFVVGLAPGQLVLECSVE---AEPAPKITW-HRDGIVLQEDAHTQFPERGR 2444 Query: 196 WVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGS 255 ++Q+ L T ++ + + + +T++ F +++ P I +V Sbjct: 2445 FLQLQALS---TADSGDYSCTARNAAGSTSVAFR----VEIHTVPTIRSGPPAVNVSVNQ 2497 Query: 256 HVSLLCGADSNPPPLLTWMRDGTVL-----REAVAESLLLELEEVTPAEDGVYACLAENA 310 L C AD P PL++W +D L R + L ++ V + G Y CLA N+ Sbjct: 2498 TALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNS 2557 Query: 311 YGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVI 370 G D + L V+ P + + C +P P++ +K+ Q L + Sbjct: 2558 AGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRL 2617 Query: 371 YESELQ------LELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL 415 + + L L A P+D ++ CV N+ G+ + ++V P + Sbjct: 2618 QQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTI 2668 Score = 65.9 bits (159), Expect = 1e-10 Identities = 53/201 (26%), Positives = 84/201 (41%), Gaps = 15/201 (7%) Query: 254 GSHVSLLCGADSNPPPLLTWMRDGTVLREAVAES---LLLELEEVTPAEDGVYACLAENA 310 G + L C A +P P + W + + E V+E L+ V+ + G Y C AEN Sbjct: 2952 GDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENR 3011 Query: 311 YGQDNRTVGLSVMYAPWKPTVNGT----MVAVEGETVSILCSTQSNPDPILTIFKEKQIL 366 G RT +S ++ P + G +V G ++ + C + +P P + K+ L Sbjct: 3012 VG---RTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPL 3068 Query: 367 STVIYESELQ---LELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAA 423 +LQ L + +D G Y C+AEN+ G L ++ APV +E Sbjct: 3069 RGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMT 3128 Query: 424 AR--DTVQCLCVVKSNPEPSV 442 R D V C P P++ Sbjct: 3129 VRSGDDVALRCQATGEPTPTI 3149 Score = 65.1 bits (157), Expect = 2e-10 Identities = 80/322 (24%), Positives = 123/322 (38%), Gaps = 43/322 (13%) Query: 150 VAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVS----LLHFV 205 + G +E+ C + P + WL + G PA +E VQV+ LH Sbjct: 511 IVGQPLELPCQASGSPV---PTIQWLQN---GRPA-------EELAGVQVASQGTTLHID 557 Query: 206 PTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEM-----------NSSVEAIEG 254 + CQA+ T E S+ ++ P ++E+ +SS A Sbjct: 558 HVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACD 617 Query: 255 SHVSLLCGADSNPPPLLTWMRDGTVLREA----VAESLL--LELEEVTPAEDGVYACLAE 308 V GA PP + W G++ E VA SL L++E+V ++G+Y C A Sbjct: 618 PPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAAT 677 Query: 309 NAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILS- 367 N G+ R V L V+ P +E +V++ C P P ++ FK Q +S Sbjct: 678 NLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSS 737 Query: 368 ----TVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHC-- 421 TV + + L + D G Y CVA N G + L V P + L Sbjct: 738 WMGVTVSVDGRV-LRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPG 796 Query: 422 -AAARDTVQCLCVVKSNPEPSV 442 V+ C P P++ Sbjct: 797 PVLVNTPVRLTCNATGAPSPTL 818 Score = 59.3 bits (142), Expect = 1e-08 Identities = 81/332 (24%), Positives = 128/332 (38%), Gaps = 54/332 (16%) Query: 148 EVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPT 207 + VAG V + C+ + P LSW HEGL E +G S+L Sbjct: 416 KAVAGRPVALECVARGHPS---PTLSW-HHEGLPVAESNESRLETDG-----SVLRLESP 466 Query: 208 REANGHRLGCQASFP--NTTLQFEGYASMDVKYPP--VIVEMNSSVEAIEGSHVSLLCGA 263 EA+ C AS P LQ+ S++V+ PP ++ E V I G + L C A Sbjct: 467 GEASSGLYSCVASSPAGEAVLQY----SVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQA 522 Query: 264 DSNPPPLLTWMRDGTVLRE-----AVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTV 318 +P P + W+++G E ++ L ++ V G++AC A N G V Sbjct: 523 SGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEV 582 Query: 319 GLSVMYAPWKPTVNGTMVA------VEGETVSILCSTQ------SNPDPIL--------T 358 +SV + W P V + + C ++P P L + Sbjct: 583 EVSV-HGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGS 641 Query: 359 IFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQ--RATAFNL----SVEFA 412 ++ E + V Y L++ V D+G Y C A N G+ R A + ++E Sbjct: 642 LWGEPTGI-PVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPG 700 Query: 413 PVLLLESHCAAARDTVQCLCVVKSNPEPSVAF 444 PV + +V C+ P P V++ Sbjct: 701 PV----NKAVLENASVTLECLASGVPPPDVSW 728 Score = 58.2 bits (139), Expect = 2e-08 Identities = 68/255 (26%), Positives = 102/255 (40%), Gaps = 24/255 (9%) Query: 170 PELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFE 229 P + W ++ P G +D G+ +Q + + +RE +G + C A N + + Sbjct: 2967 PRIGWTVND---RPVTEGVSEQDGGSTLQRAAV----SREDSGTYV-CWAE--NRVGRTQ 3016 Query: 230 GYASMDVKYPPVIVEMNSS--VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAES 287 + + VK PV+ S VE + GS + L C +P P + W++DG LR + Sbjct: 3017 AVSFVHVKEAPVLQGEAFSYLVEPVGGS-IQLDCVVRGDPVPDIHWIKDGLPLRGSHLRH 3075 Query: 288 LL----LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETV 343 L L + + G Y CLAEN G + V L + AP M G+ V Sbjct: 3076 QLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDV 3135 Query: 344 SILCSTQSNPDPILTIFKEKQILST-----VIYESELQLELPAVSPEDDGEYWCVAENQY 398 ++ C P P + + Q L + + L LE V D G Y CVA N Sbjct: 3136 ALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLE--NVETGDAGTYDCVAHNLL 3193 Query: 399 GQRATAFNLSVEFAP 413 G L V P Sbjct: 3194 GSATARAFLVVRGEP 3208 Score = 52.8 bits (125), Expect = 1e-06 Identities = 54/231 (23%), Positives = 83/231 (35%), Gaps = 13/231 (5%) Query: 239 PPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAE-------SLLLE 291 PP I S++ + L C A +P PL+ W +DG L + + S L Sbjct: 2572 PPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALL 2631 Query: 292 LEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQS 351 L P + + C+ N G+ +R ++V P V + C + Sbjct: 2632 LTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTG 2691 Query: 352 NPDPILTIFKEKQIL----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNL 407 P P ++ K L S LE+ P G Y C A N G L Sbjct: 2692 IPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFL 2751 Query: 408 SVEFAPVL--LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNES 456 +V+ +PV+ L A A + V C P P++ ++ NV S Sbjct: 2752 TVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVS 2802 Score = 48.1 bits (113), Expect = 2e-05 Identities = 65/280 (23%), Positives = 100/280 (35%), Gaps = 60/280 (21%) Query: 217 CQASFPNTTLQFEGYASMDVKYPPVIVE--MNSSVEAIEGSHVSLLCGADSNPPPLLTWM 274 CQA+ N A + V PP I E ++V + G ++L C A+ P P + W+ Sbjct: 74 CQAT--NEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWL 131 Query: 275 RDGTVL--------------------REAVAESLLLELEEVTPAEDGVYACLA-ENAYGQ 313 +D ++ + E L + P G A +A + Sbjct: 132 KDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTK 191 Query: 314 DNRTVGLS---------VMYAPWKPTVNGTMVAVE-----GETVSILCSTQSNPDPILTI 359 GL+ P P+V G A E G V + C T P P + Sbjct: 192 APWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEW 251 Query: 360 FKEKQIL-----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAP- 413 K++Q + + E L + D+G Y CVA + GQ+A F L V P Sbjct: 252 TKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPT 311 Query: 414 ---------VLLLESHCAAARDTVQCLCVVKSNPEPSVAF 444 V ++E H VQ LC + P P++ + Sbjct: 312 IWGSNETGEVAVMEDH------LVQLLCEARGVPTPNITW 345 Score = 45.4 bits (106), Expect = 2e-04 Identities = 35/116 (30%), Positives = 50/116 (43%), Gaps = 12/116 (10%) Query: 261 CGADSNPPPLLTWMRDGTVLRE-------AVAESLLLELEEVTPAEDGVYACLAENAYGQ 313 CG P P +TW R G AV E L L V+PA+ G Y C A N G Sbjct: 24 CGTHGTPKPQVTW-RKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGS 82 Query: 314 DNRTVGLSVMYAPWKPTVNGTMVAVE---GETVSILCSTQSNPDPILTIFKEKQIL 366 +R L V+Y P +G V G+++++ C P P + K+ Q++ Sbjct: 83 TSRRAKL-VVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLV 137 Score = 30.8 bits (68), Expect = 3.9 Identities = 23/72 (31%), Positives = 28/72 (38%), Gaps = 5/72 (6%) Query: 347 CSTQSNPDPILTIFKEKQILST-----VIYESELQLELPAVSPEDDGEYWCVAENQYGQR 401 C T P P +T K V E L L +VSP D G+Y C A N+ G Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGST 83 Query: 402 ATAFNLSVEFAP 413 + L V P Sbjct: 84 SRRAKLVVYVPP 95 >gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] Length = 5065 Score = 95.9 bits (237), Expect = 1e-19 Identities = 93/353 (26%), Positives = 155/353 (43%), Gaps = 33/353 (9%) Query: 131 EHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLR 190 +H L + +P + P VV E + + RP ++W EGL + Sbjct: 3938 KHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQ-KEGLNVATGVSTQV 3996 Query: 191 EDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVE 250 G Q+ + H P E G+ L C A N+ G + V+ PPVI + Sbjct: 3997 LPGG---QLRIAHASP--EDAGNYL-CIAK--NSAGSAMGKTRLVVQVPPVIENGLPDLS 4048 Query: 251 AIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-----VAESLLLELEEVTPAEDGVYAC 305 EGSH L C A +P P +TW +DG + A + S L ++ + + G Y C Sbjct: 4049 TTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTC 4108 Query: 306 LAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQI 365 AENA G+ R V L+++ P T+ G G+ + + C+ + +P P + + Sbjct: 4109 TAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRP 4168 Query: 366 LSTVIYESE--LQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAA 423 ++ + E + L+ AVS ED G Y C AEN+ G+ + V+ APVL E+ Sbjct: 4169 VTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYL 4228 Query: 424 AR---DTVQCLCVVKSNPEPSVAF--------------ELPSRNVTVNESERE 459 ++Q CVV+ +P P + + +L + ++T++ +ER+ Sbjct: 4229 VEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERD 4281 Score = 92.0 bits (227), Expect = 1e-18 Identities = 93/329 (28%), Positives = 138/329 (41%), Gaps = 35/329 (10%) Query: 143 IVVPPEVVAGTE-------VEVSCMVPDNCPELR---PELSWLGHEGLGEPAVLGRLRED 192 ++ PP ++ TE V S V CP L P +SWL + P+ ++ ED Sbjct: 2838 VLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLED 2897 Query: 193 EGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMN-SSVEA 251 G +QVS A+ C A N E ++ V+ PP I ++ V A Sbjct: 2898 -GQVLQVSTAEV-----ADAASYMCVAE--NQAGSAEKLFTLRVQVPPRIAGLDLEQVTA 2949 Query: 252 IEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-----LELEEVTPAEDGVYACL 306 I S VSL C ++P P +TW +D L LL L+L ++ G+Y C Sbjct: 2950 ILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCE 3009 Query: 307 AENAYGQDNRTVGLSVMYAP-WKPTVNGTMVAV---EGETVSILCSTQSNPDPILTIFKE 362 A NA G+D + V LSV+ P ++ G AV G+ + C T + P+P +T +K+ Sbjct: 3010 ALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKD 3069 Query: 363 KQIL----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL--- 415 Q L T +LE+ D G Y C N G+ F L+V+ P Sbjct: 3070 GQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENP 3129 Query: 416 LLESHCAAARDTVQCLCVVKSNPEPSVAF 444 E+ A + C V P P+V + Sbjct: 3130 KTETVSQVAGSPLVLTCDVSGVPAPTVTW 3158 Score = 87.8 bits (216), Expect = 3e-17 Identities = 93/374 (24%), Positives = 151/374 (40%), Gaps = 29/374 (7%) Query: 137 IVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTW 196 +V PN+ V P G +SC V P L+W+ + PA GR+ + Sbjct: 520 LVPAPNVTVSP----GETAVLSCRVLGEAPY---NLTWV-RDWRVLPASTGRVAQLADLS 571 Query: 197 VQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSH 256 +++S + +PT +G R C AS N + + + V+ P + SS +G Sbjct: 572 LEISGI--IPT---DGGRYQCVASNANGVTRASVW--LLVREAPQVSIHTSSQHFSQGVE 624 Query: 257 VSLLCGADSNPPPLLTWMRDGTVLREA----VAESLLLELEEVTPAEDGVYACLAENAYG 312 V + C A P P ++W R+ L+E V L ++ V P + G Y+C A N G Sbjct: 625 VKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVG 684 Query: 313 QDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFK-EKQILSTVIY 371 D TV L P VN ++ GE ++C P P + ++ +++ Sbjct: 685 TDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEG 744 Query: 372 ESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL--LLESHCAAARDTVQ 429 S +L +PA D G Y C A N+ G + L+V AP L L + Sbjct: 745 SSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSAL 804 Query: 430 CLCVVKSNPEPSVAF---ELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQAQAPPRV 486 C P P+V + + + + SG++ ++ + QAP Sbjct: 805 LACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFE--SVAPEDQAP--Y 860 Query: 487 ICTARNLYGAKSLE 500 +C ARN++G E Sbjct: 861 VCEARNVFGKVQAE 874 Score = 83.2 bits (204), Expect = 7e-16 Identities = 70/270 (25%), Positives = 112/270 (41%), Gaps = 17/270 (6%) Query: 236 VKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-----VAESLLL 290 V PP I + + + V L C + P P ++W + G L V+ S L Sbjct: 3853 VHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGAL 3912 Query: 291 ELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQ 350 E+ + P G Y C A N+ G ++ V L+V +P + + AV E V + C Sbjct: 3913 EIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEAS 3972 Query: 351 SNPDPILTIFKEKQILSTVIYESEL---QLELPAVSPEDDGEYWCVAENQYGQRATAFNL 407 P P +T KE ++T + L QL + SPED G Y C+A+N G L Sbjct: 3973 GIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRL 4032 Query: 408 SVEFAPVLL--LESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSER 465 V+ PV+ L C + +PEP++ ++ + V+ +E +F Sbjct: 4033 VVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQ--PVSGAEGKFTIQPS 4090 Query: 466 SGLVLTSILTLRGQAQAPPRVICTARNLYG 495 L++ ++ + Q CTA N G Sbjct: 4091 GELLVKNL-----EGQDAGTYTCTAENAVG 4115 Score = 81.6 bits (200), Expect = 2e-15 Identities = 93/419 (22%), Positives = 163/419 (38%), Gaps = 51/419 (12%) Query: 142 NIVVPPEVVAGTEVEVSCMVPDNCPELR---------PELSWLGHEGLGEPAVLGRLRED 192 +++VPPE++ + + + P P + W E EP G ED Sbjct: 2345 SVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGE---EPVSPG---ED 2398 Query: 193 EGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIV--EMNSSVE 250 +L T+E + C AS N + S++V PP I ++ ++ Sbjct: 2399 TYLLAGGWMLKMTQTQEQDSGLYSCLAS--NEAGEARRNFSVEVLVPPSIENEDLEEVIK 2456 Query: 251 AIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVA-----ESLLLELEEVTPAEDGVYAC 305 ++G L+C +P P LTW +DG L A + +LL++ + + G Y+C Sbjct: 2457 VLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSC 2516 Query: 306 LAENAYGQDNRTVGLSVMYAPW-----KPTVNGTMVAVEGETVSILCSTQSNPDPILTIF 360 +A NA G+ + LSV+ AP + + + + +S++C + P P +T Sbjct: 2517 IAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWM 2576 Query: 361 KE----KQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL 416 K+ + + + L++ ED G+Y CV N+ G+ +++ V P + Sbjct: 2577 KDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSIS 2636 Query: 417 LESHC---------AAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSG 467 + T+ C + P P++ + + VT S R V E Sbjct: 2637 KDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVT--PSSRLQVLGEGRL 2694 Query: 468 LVLTSILTLRGQAQAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAIL 526 L + Q R +C A N+ G + M+ K+G A AF IL Sbjct: 2695 LQIQPT-----QVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSA--AFEIL 2746 Score = 80.9 bits (198), Expect = 3e-15 Identities = 70/286 (24%), Positives = 117/286 (40%), Gaps = 30/286 (10%) Query: 234 MDVKYPPVIV---EMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL- 289 ++V PP I E + V ++ +L C A PPP +TW RDG + + L Sbjct: 2250 LEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQN 2309 Query: 290 ----LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAP-----WKPTVNGTMVAVEG 340 L +E A G Y+C+AEN G+ R LSV+ P P N + A Sbjct: 2310 QGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTN--ITAALH 2367 Query: 341 ETVSILCSTQSNPDPILTIFKEKQILS----TVIYESELQLELPAVSPEDDGEYWCVAEN 396 +++LC P P + F+ ++ +S T + L++ +D G Y C+A N Sbjct: 2368 SPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASN 2427 Query: 397 QYGQRATAFNLSVEFAPVL----LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVT 452 + G+ F++ V P + L E T +C V +P+P + + R + Sbjct: 2428 EAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLA 2487 Query: 453 VNESEREFVYSERSGLVLTSILTLRGQAQAPPRVICTARNLYGAKS 498 ++ + G++L L+ + C A N G K+ Sbjct: 2488 RGDAH----HISPDGVLLQ---VLQANLSSAGHYSCIAANAVGEKT 2526 Score = 80.1 bits (196), Expect = 6e-15 Identities = 87/368 (23%), Positives = 153/368 (41%), Gaps = 42/368 (11%) Query: 149 VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSL----LHF 204 V+ G EV + C P P+++WL G P L +D G ++ L L Sbjct: 3229 VLEGQEVRLDCEADGQPP---PDVAWLKD---GSP-----LGQDMGPHLRFYLDGGSLVL 3277 Query: 205 VPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVI---VEMNSSVEAIEGSHVSLLC 261 R ++ C A N + +++V PP I + + ++ + G V+++C Sbjct: 3278 KGLRASDAGAYTCVAH--NPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVC 3335 Query: 262 GADSNPPPLLTWMRDGTVLREAVAESL-----LLELEEVTPAEDGVYACLAENAYGQDNR 316 +PP ++W++DG L + L L + +V A+ G++ C+A + G +R Sbjct: 3336 PVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADR 3395 Query: 317 TVGLSVMYAPWKPTVN--GTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESE 374 L V P V +V V G V + C + P P+++ K+ + L + E Sbjct: 3396 NFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQG 3455 Query: 375 LQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAAARDT----VQC 430 L+L AV D G Y CVA ++ G+ F L+V P + T ++ Sbjct: 3456 PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMEL 3515 Query: 431 LCVVKSNPEPSVAFELPSRNVT--VNESEREFVYSERSGLVLTSIL---------TLRGQ 479 LC + P+P++ + + +T N S V R + T + + R + Sbjct: 3516 LCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVR 3575 Query: 480 AQAPPRVI 487 QAPP ++ Sbjct: 3576 VQAPPNIV 3583 Score = 79.7 bits (195), Expect = 7e-15 Identities = 60/225 (26%), Positives = 96/225 (42%), Gaps = 35/225 (15%) Query: 255 SHVSLLCGADSNPPPLLTWMRDGTVLR-----EAVAESLLLELEEVTPAEDGVYACLAEN 309 S ++L C + + PPP + W +DG + + + E LL+++ ++ G Y C+A N Sbjct: 2655 STLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATN 2714 Query: 310 AYGQDNRTVGLSVMYAPWKPTVNGTMVA--------------------VEGETVSILCST 349 G+D++ + + P V A VE + C T Sbjct: 2715 VAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDT 2774 Query: 350 QSNPDPILTIFKEKQILSTVIYESELQ----LELPAVSPEDDGEYWCVAENQYGQRATAF 405 + P P LT ++E Q LS S LQ L++P V E+ G Y C A N+ G+ + Sbjct: 2775 NAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHY 2834 Query: 406 NLSVEFAPVL------LLESHCAAARDTVQCLCVVKSNPEPSVAF 444 L V PV+ L+E A TV C NP P++++ Sbjct: 2835 ELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISW 2879 Score = 78.2 bits (191), Expect = 2e-14 Identities = 91/351 (25%), Positives = 138/351 (39%), Gaps = 57/351 (16%) Query: 130 SEHSVLDIVNTPNIVVPP---EVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVL 186 S VL + P + P +V+ G ++++C+ N PE P+LSW + V+ Sbjct: 1109 SHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGN-PE--PQLSW------SKDGVV 1159 Query: 187 GRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPV--IVE 244 + R +G+ +HF R ++ R C+AS +E + V PP E Sbjct: 1160 LQGRGPQGS------VHFAAIRTSDAGRYRCEASNSAGVDAWE--VELRVLEPPHWGADE 1211 Query: 245 MNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLRE-------AVAESLLLELEEVTP 297 + +E + G + SL C A P P +TW R G AV E L L V+P Sbjct: 1212 TSGLLERVAGENASLPCPARGTPKPQVTW-RKGPSSEPLHGQPGVAVLEEGSLFLASVSP 1270 Query: 298 AEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEG---ETVSILCSTQSNPD 354 A+ G Y C A N G +R L V+Y P +G V G +++++ C P Sbjct: 1271 ADSGDYECQATNEVGSTSRRAKL-VVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPV 1329 Query: 355 PILTIFKEKQILSTVI-------------------YESELQLELPAVSPEDDGEYWCVAE 395 P + K+ Q++ + + L P + D G Y C AE Sbjct: 1330 PEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAE 1389 Query: 396 NQYGQRATAFNLSVEFAPVLL----LESHCAAARDTVQCLCVVKSNPEPSV 442 NQ G F+L V P +L + A V+ C P P V Sbjct: 1390 NQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQV 1440 Score = 76.6 bits (187), Expect = 6e-14 Identities = 94/383 (24%), Positives = 142/383 (37%), Gaps = 51/383 (13%) Query: 141 PNIVVPPE----VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTW 196 P I +PP V+ T V ++C P P L WL PA L+ G Sbjct: 1977 PRITLPPSLPGPVLVNTPVRLTCNAT-GAPS--PTLMWLKDGNPVSPAGTPGLQVFPGGR 2033 Query: 197 VQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSH 256 V L R ++ R C A + + + V PP I+ +V + Sbjct: 2034 V----LTLASARASDSGRYSCVAV--SAVGEDRQDVVLQVHMPPSILGEELNVSVVANES 2087 Query: 257 VSLLCGADSNPPPLLTWMRDGTVLR-----EAVAESLLLELEEVTPAEDGVYACLAENAY 311 V+L C + + PPP+L+W +DG L A+ LL+++ + G Y C A N Sbjct: 2088 VALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQA 2147 Query: 312 GQDNRTVGLSVMYAPWKP-TVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQIL---- 366 G + L+V AP P + T+ EG S+ C + P P ++ K+ Q L Sbjct: 2148 GHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEG 2207 Query: 367 ---------STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL- 416 ++Y + QL +G Y C N G + L V P + Sbjct: 2208 AGLQHVSAVGRLLYLGQAQL-------AQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAG 2260 Query: 417 ---LESHCAAARDTVQCL-CVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTS 472 + + +D V L C P P+V +E + V + + G S Sbjct: 2261 PREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELG----LQLQNQG---QS 2313 Query: 473 ILTLRGQAQAPPRVICTARNLYG 495 + R QA R C A NL G Sbjct: 2314 LHVERAQAAHTGRYSCVAENLAG 2336 Score = 74.3 bits (181), Expect = 3e-13 Identities = 55/176 (31%), Positives = 77/176 (43%), Gaps = 8/176 (4%) Query: 232 ASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVL-----REAVAE 286 A + V PP + +V G L C P LTW+RD VL R A Sbjct: 509 AQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLA 568 Query: 287 SLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSIL 346 L LE+ + P + G Y C+A NA G +V L V AP + +G V + Sbjct: 569 DLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVS 628 Query: 347 CSTQSNPDPILTIFKEKQIL---STVIYESELQLELPAVSPEDDGEYWCVAENQYG 399 CS P P ++ +E Q L S + +++ L + V+PED G Y C A N+ G Sbjct: 629 CSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVG 684 Score = 73.9 bits (180), Expect = 4e-13 Identities = 67/239 (28%), Positives = 100/239 (41%), Gaps = 13/239 (5%) Query: 186 LGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYAS----MDVKYPPV 241 + RL + W + LL R A ++G + T G AS + V+ PP Sbjct: 1063 VNRLALSKYVWEEYGLLPSGSLRLAQV-QVGDSGHYECTASNPAGSASHRYVLGVQVPPQ 1121 Query: 242 IVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDG 301 + ++ + G + L C A+ NP P L+W +DG VL+ + + + ++ G Sbjct: 1122 VQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQGRGPQG-SVHFAAIRTSDAG 1180 Query: 302 VYACLAENAYGQDNRTVGLSVMYAP-W-KPTVNGTMVAVEGETVSILCSTQSNPDPILTI 359 Y C A N+ G D V L V+ P W +G + V GE S+ C + P P +T Sbjct: 1181 RYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTW 1240 Query: 360 FKEKQI-----LSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAP 413 K V E L L +VSP D G+Y C A N+ G + L V P Sbjct: 1241 RKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPP 1299 Score = 72.8 bits (177), Expect = 9e-13 Identities = 63/224 (28%), Positives = 92/224 (41%), Gaps = 20/224 (8%) Query: 250 EAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-----LELEEVTPAEDGVYA 304 E +E + L C ++ PPP LTW R+ L S+L L++ V G Y+ Sbjct: 2761 EIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYS 2820 Query: 305 CLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVE------GETVSILCSTQSNPDPILT 358 C A N G+D L V+ P + T VE TVS+ C NP P ++ Sbjct: 2821 CKASNEVGEDWLHYELLVLTPP--VILGDTEELVEEVTVNASSTVSLQCPALGNPVPTIS 2878 Query: 359 IFKEKQILS----TVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPV 414 + S + E L++ D Y CVAENQ G F L V+ P Sbjct: 2879 WLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPR 2938 Query: 415 LL---LESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNE 455 + LE A +V C V ++P P V + S+ +++ E Sbjct: 2939 IAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGE 2982 Score = 72.4 bits (176), Expect = 1e-12 Identities = 63/229 (27%), Positives = 97/229 (42%), Gaps = 26/229 (11%) Query: 236 VKYPPVIVEMNSS--VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-----VAESL 288 V PP I N + V +E V LLC A P P +TW +DG +L + Sbjct: 1497 VHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGR 1556 Query: 289 LLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNG------TMVAVEGET 342 L+L ++ GVY C A NA G + L V Y P PT+ G + AV G Sbjct: 1557 QLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV-YVP--PTIEGAGGRPYVVKAVAGRP 1613 Query: 343 VSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGE-----YWCVAENQ 397 V++ C + +P P L+ + + + ES L+ + + E GE Y CVA + Sbjct: 1614 VALECVARGHPSPTLS-WHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSP 1672 Query: 398 YGQRATAFNLSVEFAPVLLLESHCAAARDTV----QCLCVVKSNPEPSV 442 G+ +++ V+ P LL+ V + C +P P++ Sbjct: 1673 AGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTI 1721 Score = 72.4 bits (176), Expect = 1e-12 Identities = 95/381 (24%), Positives = 143/381 (37%), Gaps = 53/381 (13%) Query: 134 VLDIVNTPNIVVPPEVVAGTEVEVSCM---VPDNCPELRPELSWLGHEGLGEPAVLGRLR 190 VL+ V N VV VV G+ VE+ C VP P +SW+ GEP + L Sbjct: 3406 VLEPVEFQNDVV---VVRGSLVELPCEARGVP------LPLVSWMKD---GEPLLSQSLE 3453 Query: 191 EDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYA----SMDVKYPPVIVEMN 246 + P+ + G ++ + G A + V PP I + Sbjct: 3454 QG-------------PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSG 3500 Query: 247 SSVEA--IEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDGVYA 304 E G+ + LLC A P P +TW +DG L S + V A G+Y Sbjct: 3501 QPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDA--GLYT 3558 Query: 305 CLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAV---EGETVSILCSTQSNPDPILTIFK 361 CLAE+ G ++ + V P G V G+ V + CS ++ P P +T + Sbjct: 3559 CLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLV-LECSVEAEPAPKITWHR 3617 Query: 362 EKQILS----TVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLL 417 + +L T E L+L A+S D G+Y C A N G + AF + + P + Sbjct: 3618 DGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRS 3677 Query: 418 ESHC--AAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILT 475 + T C P P V++ V ++ F L + +L Sbjct: 3678 GPPAVNVSVNQTALLPCQADGVPAPLVSWR--KDRVPLDPRSPRFEILPEGSLRIQPVL- 3734 Query: 476 LRGQAQAPPRVICTARNLYGA 496 AQ +C A N G+ Sbjct: 3735 ----AQDAGHYLCLASNSAGS 3751 Score = 69.7 bits (169), Expect = 8e-12 Identities = 50/200 (25%), Positives = 86/200 (43%), Gaps = 20/200 (10%) Query: 233 SMDVKYPPVIVEMNS-SVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-- 289 ++ V+ PP + +V + GS + L C P P +TW++D + + ++ Sbjct: 3117 TLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSR 3176 Query: 290 ---LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVA-----VEGE 341 L+L + PA+ G Y C+AEN + + ++V+ A P + + VA +EG+ Sbjct: 3177 GGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVA---PRIRSSGVAREHHVLEGQ 3233 Query: 342 TVSILCSTQSNPDPILTIFKEKQILSTVI------YESELQLELPAVSPEDDGEYWCVAE 395 V + C P P + K+ L + Y L L + D G Y CVA Sbjct: 3234 EVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAH 3293 Query: 396 NQYGQRATAFNLSVEFAPVL 415 N G+ A ++V P + Sbjct: 3294 NPAGEDARLHTVNVLVPPTI 3313 Score = 67.4 bits (163), Expect = 4e-11 Identities = 71/272 (26%), Positives = 100/272 (36%), Gaps = 16/272 (5%) Query: 149 VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTR 208 V G ++C P P ++W +G LG R +L F Sbjct: 797 VELGRSALLACRATGRPP---PTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVA 853 Query: 209 EANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPP 268 + C+A +Q E + PP I +V +EG VSL C + P Sbjct: 854 PEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRP 913 Query: 269 -PLLTWMRDGTVL----REAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVM 323 P W++DG L R ++ L L+ G Y+C+A N G +R V L V Sbjct: 914 LPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQ 973 Query: 324 YAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILST------VIYESELQL 377 P + EG S+ C P P +T KE L++ V E L + Sbjct: 974 VPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLI 1033 Query: 378 ELPAVSPEDDGEYWCVAENQYGQRATAFNLSV 409 P S +D G Y C A N G + LSV Sbjct: 1034 AQP--SAQDAGAYVCTATNTVGFSSQEMRLSV 1063 Score = 66.6 bits (161), Expect = 6e-11 Identities = 68/270 (25%), Positives = 104/270 (38%), Gaps = 53/270 (19%) Query: 217 CQASFPNTTLQFEGYASMDVKYPPVIVE--MNSSVEAIEGSHVSLLCGADSNPPPLLTWM 274 CQA+ N A + V PP I E ++V + G ++L C A+ P P + W+ Sbjct: 1278 CQAT--NEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWL 1335 Query: 275 RDGTVL--------------------REAVAESLLLELEEVTPAEDGVYACLAENAYGQD 314 +D ++ + E L + + G+Y+C AEN G Sbjct: 1336 KDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTA 1395 Query: 315 NRTVGLSVMYAPWKPTVNGTMVAVE-----GETVSILCSTQSNPDPILTIFKEKQIL--- 366 R L V+ P +V G A E G V + C T P P + K++Q + Sbjct: 1396 QRDFHLLVLTPP---SVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPG 1452 Query: 367 --STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAP----------V 414 + E L + D+G Y CVA + GQ+A F L V P V Sbjct: 1453 GPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEV 1512 Query: 415 LLLESHCAAARDTVQCLCVVKSNPEPSVAF 444 ++E H VQ LC + P P++ + Sbjct: 1513 AVMEDH------LVQLLCEARGVPTPNITW 1536 Score = 65.9 bits (159), Expect = 1e-10 Identities = 103/422 (24%), Positives = 154/422 (36%), Gaps = 44/422 (10%) Query: 101 TLLLSNVSPELGGKYYFRG--DLGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVS 158 TL++ V+PE G Y + ++G + ++ V+ N VV V G E + Sbjct: 661 TLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVL--VAVGEEAVLV 718 Query: 159 CMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQ 218 C P P + W + G G +L G L +E + C+ Sbjct: 719 CEASGVPP---PRVIW--YRG-GLEMILAPEGSSSGK------LRIPAAQERDAGTYTCR 766 Query: 219 ASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMR-DG 277 A N + V + P + E+ V G L C A PPP +TW R DG Sbjct: 767 AV--NELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDG 824 Query: 278 TVL----------REAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVM-YAP 326 L R +S +L E V P + Y C A N +G+ L V +AP Sbjct: 825 QPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAP 884 Query: 327 WKPTVNGTMVAV-EGETVSILCSTQSN-PDPILTIFKEKQIL---STVIYESELQLELPA 381 + + V V EG+ VS+ C + P P K+ + L S ++ L L Sbjct: 885 PQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDR 944 Query: 382 VSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL--LLESHCAAARDTVQCLCVVKSNPE 439 E G Y CVA N G + L V+ P + H CV P Sbjct: 945 ALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPA 1004 Query: 440 PSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQAQAPPRVICTARNLYGAKSL 499 P++ + + +T S + G ++L + AQ +CTA N G S Sbjct: 1005 PTITWTKETNALT---SRGPHYNVSKEG----TLLIAQPSAQDAGAYVCTATNTVGFSSQ 1057 Query: 500 EL 501 E+ Sbjct: 1058 EM 1059 Score = 65.9 bits (159), Expect = 1e-10 Identities = 64/291 (21%), Positives = 117/291 (40%), Gaps = 27/291 (9%) Query: 141 PNIVVP--PEVVAGT---EVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGT 195 PNIV P P V G ++ + C V E P+++W +G+ + G Sbjct: 3580 PNIVGPRGPRFVVGLAPGQLVLECSVE---AEPAPKITW-HRDGIVLQEDAHTQFPERGR 3635 Query: 196 WVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGS 255 ++Q+ L T ++ + + + +T++ F +++ P I +V Sbjct: 3636 FLQLQALS---TADSGDYSCTARNAAGSTSVAFR----VEIHTVPTIRSGPPAVNVSVNQ 3688 Query: 256 HVSLLCGADSNPPPLLTWMRDGTVL-----REAVAESLLLELEEVTPAEDGVYACLAENA 310 L C AD P PL++W +D L R + L ++ V + G Y CLA N+ Sbjct: 3689 TALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNS 3748 Query: 311 YGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVI 370 G D + L V+ P + + C +P P++ +K+ Q L + Sbjct: 3749 AGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRL 3808 Query: 371 YESELQ------LELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL 415 + + L L A P+D ++ CV N+ G+ + ++V P + Sbjct: 3809 QQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTI 3859 Score = 65.9 bits (159), Expect = 1e-10 Identities = 53/201 (26%), Positives = 84/201 (41%), Gaps = 15/201 (7%) Query: 254 GSHVSLLCGADSNPPPLLTWMRDGTVLREAVAES---LLLELEEVTPAEDGVYACLAENA 310 G + L C A +P P + W + + E V+E L+ V+ + G Y C AEN Sbjct: 4143 GDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENR 4202 Query: 311 YGQDNRTVGLSVMYAPWKPTVNGT----MVAVEGETVSILCSTQSNPDPILTIFKEKQIL 366 G RT +S ++ P + G +V G ++ + C + +P P + K+ L Sbjct: 4203 VG---RTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPL 4259 Query: 367 STVIYESELQ---LELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAA 423 +LQ L + +D G Y C+AEN+ G L ++ APV +E Sbjct: 4260 RGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMT 4319 Query: 424 AR--DTVQCLCVVKSNPEPSV 442 R D V C P P++ Sbjct: 4320 VRSGDDVALRCQATGEPTPTI 4340 Score = 65.1 bits (157), Expect = 2e-10 Identities = 80/322 (24%), Positives = 123/322 (38%), Gaps = 43/322 (13%) Query: 150 VAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVS----LLHFV 205 + G +E+ C + P + WL + G PA +E VQV+ LH Sbjct: 1702 IVGQPLELPCQASGSPV---PTIQWLQN---GRPA-------EELAGVQVASQGTTLHID 1748 Query: 206 PTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEM-----------NSSVEAIEG 254 + CQA+ T E S+ ++ P ++E+ +SS A Sbjct: 1749 HVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACD 1808 Query: 255 SHVSLLCGADSNPPPLLTWMRDGTVLREA----VAESLL--LELEEVTPAEDGVYACLAE 308 V GA PP + W G++ E VA SL L++E+V ++G+Y C A Sbjct: 1809 PPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAAT 1868 Query: 309 NAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILS- 367 N G+ R V L V+ P +E +V++ C P P ++ FK Q +S Sbjct: 1869 NLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSS 1928 Query: 368 ----TVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHC-- 421 TV + + L + D G Y CVA N G + L V P + L Sbjct: 1929 WMGVTVSVDGRV-LRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPG 1987 Query: 422 -AAARDTVQCLCVVKSNPEPSV 442 V+ C P P++ Sbjct: 1988 PVLVNTPVRLTCNATGAPSPTL 2009 Score = 59.3 bits (142), Expect = 1e-08 Identities = 81/332 (24%), Positives = 128/332 (38%), Gaps = 54/332 (16%) Query: 148 EVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPT 207 + VAG V + C+ + P LSW HEGL E +G S+L Sbjct: 1607 KAVAGRPVALECVARGHPS---PTLSW-HHEGLPVAESNESRLETDG-----SVLRLESP 1657 Query: 208 REANGHRLGCQASFP--NTTLQFEGYASMDVKYPP--VIVEMNSSVEAIEGSHVSLLCGA 263 EA+ C AS P LQ+ S++V+ PP ++ E V I G + L C A Sbjct: 1658 GEASSGLYSCVASSPAGEAVLQY----SVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQA 1713 Query: 264 DSNPPPLLTWMRDGTVLRE-----AVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTV 318 +P P + W+++G E ++ L ++ V G++AC A N G V Sbjct: 1714 SGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEV 1773 Query: 319 GLSVMYAPWKPTVNGTMVA------VEGETVSILCSTQ------SNPDPIL--------T 358 +SV + W P V + + C ++P P L + Sbjct: 1774 EVSV-HGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGS 1832 Query: 359 IFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQ--RATAFNL----SVEFA 412 ++ E + V Y L++ V D+G Y C A N G+ R A + ++E Sbjct: 1833 LWGEPTGI-PVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPG 1891 Query: 413 PVLLLESHCAAARDTVQCLCVVKSNPEPSVAF 444 PV + +V C+ P P V++ Sbjct: 1892 PV----NKAVLENASVTLECLASGVPPPDVSW 1919 Score = 58.2 bits (139), Expect = 2e-08 Identities = 68/255 (26%), Positives = 102/255 (40%), Gaps = 24/255 (9%) Query: 170 PELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFE 229 P + W ++ P G +D G+ +Q + + +RE +G + C A N + + Sbjct: 4158 PRIGWTVND---RPVTEGVSEQDGGSTLQRAAV----SREDSGTYV-CWAE--NRVGRTQ 4207 Query: 230 GYASMDVKYPPVIVEMNSS--VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAES 287 + + VK PV+ S VE + GS + L C +P P + W++DG LR + Sbjct: 4208 AVSFVHVKEAPVLQGEAFSYLVEPVGGS-IQLDCVVRGDPVPDIHWIKDGLPLRGSHLRH 4266 Query: 288 LL----LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETV 343 L L + + G Y CLAEN G + V L + AP M G+ V Sbjct: 4267 QLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDV 4326 Query: 344 SILCSTQSNPDPILTIFKEKQILST-----VIYESELQLELPAVSPEDDGEYWCVAENQY 398 ++ C P P + + Q L + + L LE V D G Y CVA N Sbjct: 4327 ALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLE--NVETGDAGTYDCVAHNLL 4384 Query: 399 GQRATAFNLSVEFAP 413 G L V P Sbjct: 4385 GSATARAFLVVRGEP 4399 Score = 52.8 bits (125), Expect = 1e-06 Identities = 54/231 (23%), Positives = 83/231 (35%), Gaps = 13/231 (5%) Query: 239 PPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAE-------SLLLE 291 PP I S++ + L C A +P PL+ W +DG L + + S L Sbjct: 3763 PPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALL 3822 Query: 292 LEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQS 351 L P + + C+ N G+ +R ++V P V + C + Sbjct: 3823 LTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTG 3882 Query: 352 NPDPILTIFKEKQIL----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNL 407 P P ++ K L S LE+ P G Y C A N G L Sbjct: 3883 IPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFL 3942 Query: 408 SVEFAPVL--LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNES 456 +V+ +PV+ L A A + V C P P++ ++ NV S Sbjct: 3943 TVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVS 3993 Score = 48.1 bits (113), Expect = 2e-05 Identities = 40/165 (24%), Positives = 65/165 (39%), Gaps = 6/165 (3%) Query: 291 ELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQ 350 E+ + AE+G Y C A + G + V P + + GET + C Sbjct: 482 EILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL 541 Query: 351 SNPDPILTIFKEKQIL----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFN 406 LT ++ ++L V ++L LE+ + P D G Y CVA N G + Sbjct: 542 GEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVW 601 Query: 407 LSVEFAPVLLL--ESHCAAARDTVQCLCVVKSNPEPSVAFELPSR 449 L V AP + + S + V+ C P P +++ S+ Sbjct: 602 LLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQ 646 Score = 46.6 bits (109), Expect = 7e-05 Identities = 41/162 (25%), Positives = 60/162 (37%), Gaps = 12/162 (7%) Query: 290 LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCST 349 L L +V + G Y C A N G + L V P + + GE + + C Sbjct: 1084 LRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVA 1143 Query: 350 QSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSV 409 + NP+P L+ K+ +L + + A+ D G Y C A N G A L V Sbjct: 1144 EGNPEPQLSWSKDGVVLQG--RGPQGSVHFAAIRTSDAGRYRCEASNSAGVDAWEVELRV 1201 Query: 410 EFAPVL-------LLESHCAAARDTVQCLCVVKSNPEPSVAF 444 P LLE A + C + P+P V + Sbjct: 1202 LEPPHWGADETSGLLE---RVAGENASLPCPARGTPKPQVTW 1240 >gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] Length = 3783 Score = 95.5 bits (236), Expect = 1e-19 Identities = 93/353 (26%), Positives = 154/353 (43%), Gaps = 33/353 (9%) Query: 131 EHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLR 190 +H L + +P + P VV E + + RP ++W EGL + Sbjct: 2656 KHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQ-KEGLNVATGVSTQV 2714 Query: 191 EDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVE 250 G Q+ + H P E G+ L C A N+ G + V+ PPVI + Sbjct: 2715 LPGG---QLRIAHASP--EDAGNYL-CIAK--NSAGSAMGKTRLVVQVPPVIENGLPDLS 2766 Query: 251 AIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-----VAESLLLELEEVTPAEDGVYAC 305 EGSH L C A +P P +TW +DG + A + S L ++ + + G Y C Sbjct: 2767 TTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTC 2826 Query: 306 LAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQI 365 AENA G+ R V L+++ P T+ G G+ + + C+ + +P P + + Sbjct: 2827 TAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRP 2886 Query: 366 LSTVIYESE--LQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAA 423 ++ + E + L+ AVS ED G Y C AEN+ G+ + V+ APVL E+ Sbjct: 2887 VTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYL 2946 Query: 424 AR---DTVQCLCVVKSNPEPSVAF--------------ELPSRNVTVNESERE 459 ++Q CVV+ +P P + + +L + ++T+ +ER+ Sbjct: 2947 VEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERD 2999 Score = 92.0 bits (227), Expect = 1e-18 Identities = 93/329 (28%), Positives = 138/329 (41%), Gaps = 35/329 (10%) Query: 143 IVVPPEVVAGTE-------VEVSCMVPDNCPELR---PELSWLGHEGLGEPAVLGRLRED 192 ++ PP ++ TE V S V CP L P +SWL + P+ ++ ED Sbjct: 1556 VLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLED 1615 Query: 193 EGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMN-SSVEA 251 G +QVS A+ C A N E ++ V+ PP I ++ V A Sbjct: 1616 -GQVLQVSTAEV-----ADAASYMCVAE--NQAGSAEKLFTLRVQVPPRIAGLDLEQVTA 1667 Query: 252 IEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-----LELEEVTPAEDGVYACL 306 I S VSL C ++P P +TW +D L LL L+L ++ G+Y C Sbjct: 1668 ILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCE 1727 Query: 307 AENAYGQDNRTVGLSVMYAP-WKPTVNGTMVAV---EGETVSILCSTQSNPDPILTIFKE 362 A NA G+D + V LSV+ P ++ G AV G+ + C T + P+P +T +K+ Sbjct: 1728 ALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKD 1787 Query: 363 KQIL----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL--- 415 Q L T +LE+ D G Y C N G+ F L+V+ P Sbjct: 1788 GQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENP 1847 Query: 416 LLESHCAAARDTVQCLCVVKSNPEPSVAF 444 E+ A + C V P P+V + Sbjct: 1848 KTETVSQVAGSPLVLTCDVSGVPAPTVTW 1876 Score = 83.2 bits (204), Expect = 7e-16 Identities = 94/419 (22%), Positives = 164/419 (39%), Gaps = 51/419 (12%) Query: 142 NIVVPPEVVAGTEVEVSCMVPDNCPELR---------PELSWLGHEGLGEPAVLGRLRED 192 +++VPPE++ + + + P P + W E EP G ED Sbjct: 1063 SVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGE---EPVSPG---ED 1116 Query: 193 EGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIV--EMNSSVE 250 +L T+E + C AS N + S++V PP I ++ ++ Sbjct: 1117 TYLLAGGWMLKMTQTQEQDSGLYSCLAS--NEAGEARRNFSVEVLVPPSIENEDLEEVIK 1174 Query: 251 AIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVA-----ESLLLELEEVTPAEDGVYAC 305 ++G L+C +P P LTW +DG L A + +LL++ + + G Y+C Sbjct: 1175 VLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSC 1234 Query: 306 LAENAYGQDNRTVGLSVMYAPW-----KPTVNGTMVAVEGETVSILCSTQSNPDPILTIF 360 +A NA G+ + LSV+ AP + + + + +S++C + P P +T Sbjct: 1235 IAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWM 1294 Query: 361 KE----KQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL 416 K+ + + + L++ ED G+Y CV N+ G+ +++ V P + Sbjct: 1295 KDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSIS 1354 Query: 417 LESHCA---------AARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSG 467 + A T+ C + P P++ + + VT S R V E Sbjct: 1355 KDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVT--PSSRLQVLGEGRL 1412 Query: 468 LVLTSILTLRGQAQAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAIL 526 L + Q R +C A N+ G + M+ K+G A AF IL Sbjct: 1413 LQIQPT-----QVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSA--AFEIL 1464 Score = 83.2 bits (204), Expect = 7e-16 Identities = 70/270 (25%), Positives = 112/270 (41%), Gaps = 17/270 (6%) Query: 236 VKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-----VAESLLL 290 V PP I + + + V L C + P P ++W + G L V+ S L Sbjct: 2571 VHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGAL 2630 Query: 291 ELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQ 350 E+ + P G Y C A N+ G ++ V L+V +P + + AV E V + C Sbjct: 2631 EIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEAS 2690 Query: 351 SNPDPILTIFKEKQILSTVIYESEL---QLELPAVSPEDDGEYWCVAENQYGQRATAFNL 407 P P +T KE ++T + L QL + SPED G Y C+A+N G L Sbjct: 2691 GIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRL 2750 Query: 408 SVEFAPVLL--LESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSER 465 V+ PV+ L C + +PEP++ ++ + V+ +E +F Sbjct: 2751 VVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQ--PVSGAEGKFTIQPS 2808 Query: 466 SGLVLTSILTLRGQAQAPPRVICTARNLYG 495 L++ ++ + Q CTA N G Sbjct: 2809 GELLVKNL-----EGQDAGTYTCTAENAVG 2833 Score = 80.9 bits (198), Expect = 3e-15 Identities = 70/286 (24%), Positives = 117/286 (40%), Gaps = 30/286 (10%) Query: 234 MDVKYPPVIV---EMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL- 289 ++V PP I E + V ++ +L C A PPP +TW RDG + + L Sbjct: 968 LEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQN 1027 Query: 290 ----LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAP-----WKPTVNGTMVAVEG 340 L +E A G Y+C+AEN G+ R LSV+ P P N + A Sbjct: 1028 QGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTN--ITAALH 1085 Query: 341 ETVSILCSTQSNPDPILTIFKEKQILS----TVIYESELQLELPAVSPEDDGEYWCVAEN 396 +++LC P P + F+ ++ +S T + L++ +D G Y C+A N Sbjct: 1086 SPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASN 1145 Query: 397 QYGQRATAFNLSVEFAPVL----LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVT 452 + G+ F++ V P + L E T +C V +P+P + + R + Sbjct: 1146 EAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLA 1205 Query: 453 VNESEREFVYSERSGLVLTSILTLRGQAQAPPRVICTARNLYGAKS 498 ++ + G++L L+ + C A N G K+ Sbjct: 1206 RGDAH----HISPDGVLLQ---VLQANLSSAGHYSCIAANAVGEKT 1244 Score = 80.1 bits (196), Expect = 6e-15 Identities = 89/371 (23%), Positives = 147/371 (39%), Gaps = 73/371 (19%) Query: 130 SEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDN--CPELR---PELSWL--------- 175 ++H L ++ P I+ E A EV V+ P + C L P ++W+ Sbjct: 1244 TKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEAS 1303 Query: 176 -------GHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQF 228 G GL +L +ED G + V + + + N H + P + + Sbjct: 1304 RNIQLLPGTHGL---QILNAQKEDAGQYTCV-VTNELGEAVKNYH---VEVLIPPSISKD 1356 Query: 229 EGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLR-----EA 283 + A + VK V+ S ++L C + + PPP + W +DG + + Sbjct: 1357 DPLAEVGVK----------EVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQV 1406 Query: 284 VAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVA------ 337 + E LL+++ ++ G Y C+A N G+D++ + + P V A Sbjct: 1407 LGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSR 1466 Query: 338 --------------VEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQ----LEL 379 VE + C T + P P LT ++E Q LS S LQ L++ Sbjct: 1467 EEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQI 1526 Query: 380 PAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL------LLESHCAAARDTVQCLCV 433 P V E+ G Y C A N+ G+ + L V PV+ L+E A TV C Sbjct: 1527 PLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCP 1586 Query: 434 VKSNPEPSVAF 444 NP P++++ Sbjct: 1587 ALGNPVPTISW 1597 Score = 80.1 bits (196), Expect = 6e-15 Identities = 87/368 (23%), Positives = 153/368 (41%), Gaps = 42/368 (11%) Query: 149 VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSL----LHF 204 V+ G EV + C P P+++WL G P L +D G ++ L L Sbjct: 1947 VLEGQEVRLDCEADGQPP---PDVAWLKD---GSP-----LGQDMGPHLRFYLDGGSLVL 1995 Query: 205 VPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVI---VEMNSSVEAIEGSHVSLLC 261 R ++ C A N + +++V PP I + + ++ + G V+++C Sbjct: 1996 KGLRASDAGAYTCVAH--NPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVC 2053 Query: 262 GADSNPPPLLTWMRDGTVLREAVAESL-----LLELEEVTPAEDGVYACLAENAYGQDNR 316 +PP ++W++DG L + L L + +V A+ G++ C+A + G +R Sbjct: 2054 PVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADR 2113 Query: 317 TVGLSVMYAPWKPTVN--GTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESE 374 L V P V +V V G V + C + P P+++ K+ + L + E Sbjct: 2114 NFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQG 2173 Query: 375 LQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAAARDT----VQC 430 L+L AV D G Y CVA ++ G+ F L+V P + T ++ Sbjct: 2174 PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMEL 2233 Query: 431 LCVVKSNPEPSVAFELPSRNVT--VNESEREFVYSERSGLVLTSIL---------TLRGQ 479 LC + P+P++ + + +T N S V R + T + + R + Sbjct: 2234 LCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVR 2293 Query: 480 AQAPPRVI 487 QAPP ++ Sbjct: 2294 VQAPPNIV 2301 Score = 74.7 bits (182), Expect = 2e-13 Identities = 93/383 (24%), Positives = 141/383 (36%), Gaps = 51/383 (13%) Query: 141 PNIVVPPE----VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTW 196 P I +PP V+ T V ++C P P L WL PA L+ G Sbjct: 695 PRITLPPSLPGPVLVNTPVRLTCNAT-GAPS--PTLMWLKDGNPVSPAGTPGLQVFPGGR 751 Query: 197 VQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSH 256 V L R ++ R C A + + + V PP I+ +V + Sbjct: 752 V----LTLASARASDSGRYSCVAV--SAVGEDRQDVVLQVHMPPSILGEELNVSVVANES 805 Query: 257 VSLLCGADSNPPPLLTWMRDGTVLR-----EAVAESLLLELEEVTPAEDGVYACLAENAY 311 V+L C + + PPP+L+W +DG L A+ LL+++ + G Y C A N Sbjct: 806 VALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQA 865 Query: 312 GQDNRTVGLSVMYAPWKP-TVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQIL---- 366 G + L+V AP P + T+ EG + C + P P ++ K+ Q L Sbjct: 866 GHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEG 925 Query: 367 ---------STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLL- 416 ++Y + QL +G Y C N G + L V P + Sbjct: 926 AGLQHVSAVGRLLYLGQAQL-------AQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAG 978 Query: 417 ---LESHCAAARDTVQCL-CVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTS 472 + + +D V L C P P+V +E + V + + G S Sbjct: 979 PREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELG----LQLQNQG---QS 1031 Query: 473 ILTLRGQAQAPPRVICTARNLYG 495 + R QA R C A NL G Sbjct: 1032 LHVERAQAAHTGRYSCVAENLAG 1054 Score = 72.4 bits (176), Expect = 1e-12 Identities = 63/229 (27%), Positives = 97/229 (42%), Gaps = 26/229 (11%) Query: 236 VKYPPVIVEMNSS--VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREA-----VAESL 288 V PP I N + V +E V LLC A P P +TW +DG +L + Sbjct: 215 VHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGR 274 Query: 289 LLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNG------TMVAVEGET 342 L+L ++ GVY C A NA G + L V Y P PT+ G + AV G Sbjct: 275 QLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV-YVP--PTIEGAGGRPYVVKAVAGRP 331 Query: 343 VSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGE-----YWCVAENQ 397 V++ C + +P P L+ + + + ES L+ + + E GE Y CVA + Sbjct: 332 VALECVARGHPSPTLS-WHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSP 390 Query: 398 YGQRATAFNLSVEFAPVLLLESHCAAARDTV----QCLCVVKSNPEPSV 442 G+ +++ V+ P LL+ V + C +P P++ Sbjct: 391 AGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTI 439 Score = 72.4 bits (176), Expect = 1e-12 Identities = 95/381 (24%), Positives = 143/381 (37%), Gaps = 53/381 (13%) Query: 134 VLDIVNTPNIVVPPEVVAGTEVEVSCM---VPDNCPELRPELSWLGHEGLGEPAVLGRLR 190 VL+ V N VV VV G+ VE+ C VP P +SW+ GEP + L Sbjct: 2124 VLEPVEFQNDVV---VVRGSLVELPCEARGVP------LPLVSWMKD---GEPLLSQSLE 2171 Query: 191 EDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYA----SMDVKYPPVIVEMN 246 + P+ + G ++ + G A + V PP I + Sbjct: 2172 QG-------------PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSG 2218 Query: 247 SSVEA--IEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDGVYA 304 E G+ + LLC A P P +TW +DG L S + V A G+Y Sbjct: 2219 QPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDA--GLYT 2276 Query: 305 CLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAV---EGETVSILCSTQSNPDPILTIFK 361 CLAE+ G ++ + V P G V G+ V + CS ++ P P +T + Sbjct: 2277 CLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLV-LECSVEAEPAPKITWHR 2335 Query: 362 EKQILS----TVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLL 417 + +L T E L+L A+S D G+Y C A N G + AF + + P + Sbjct: 2336 DGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRS 2395 Query: 418 ESHC--AAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILT 475 + T C P P V++ V ++ F L + +L Sbjct: 2396 GPPAVNVSVNQTALLPCQADGVPAPLVSWR--KDRVPLDPRSPRFEILPEGSLRIQPVL- 2452 Query: 476 LRGQAQAPPRVICTARNLYGA 496 AQ +C A N G+ Sbjct: 2453 ----AQDAGHYLCLASNSAGS 2469 Score = 69.7 bits (169), Expect = 8e-12 Identities = 50/200 (25%), Positives = 86/200 (43%), Gaps = 20/200 (10%) Query: 233 SMDVKYPPVIVEMNS-SVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL-- 289 ++ V+ PP + +V + GS + L C P P +TW++D + + ++ Sbjct: 1835 TLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSR 1894 Query: 290 ---LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVA-----VEGE 341 L+L + PA+ G Y C+AEN + + ++V+ A P + + VA +EG+ Sbjct: 1895 GGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVA---PRIRSSGVAREHHVLEGQ 1951 Query: 342 TVSILCSTQSNPDPILTIFKEKQILSTVI------YESELQLELPAVSPEDDGEYWCVAE 395 V + C P P + K+ L + Y L L + D G Y CVA Sbjct: 1952 EVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAH 2011 Query: 396 NQYGQRATAFNLSVEFAPVL 415 N G+ A ++V P + Sbjct: 2012 NPAGEDARLHTVNVLVPPTI 2031 Score = 65.9 bits (159), Expect = 1e-10 Identities = 64/291 (21%), Positives = 117/291 (40%), Gaps = 27/291 (9%) Query: 141 PNIVVP--PEVVAGT---EVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGT 195 PNIV P P V G ++ + C V E P+++W +G+ + G Sbjct: 2298 PNIVGPRGPRFVVGLAPGQLVLECSVE---AEPAPKITW-HRDGIVLQEDAHTQFPERGR 2353 Query: 196 WVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGS 255 ++Q+ L T ++ + + + +T++ F +++ P I +V Sbjct: 2354 FLQLQALS---TADSGDYSCTARNAAGSTSVAFR----VEIHTVPTIRSGPPAVNVSVNQ 2406 Query: 256 HVSLLCGADSNPPPLLTWMRDGTVL-----REAVAESLLLELEEVTPAEDGVYACLAENA 310 L C AD P PL++W +D L R + L ++ V + G Y CLA N+ Sbjct: 2407 TALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNS 2466 Query: 311 YGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVI 370 G D + L V+ P + + C +P P++ +K+ Q L + Sbjct: 2467 AGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRL 2526 Query: 371 YESELQ------LELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL 415 + + L L A P+D ++ CV N+ G+ + ++V P + Sbjct: 2527 QQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTI 2577 Score = 65.9 bits (159), Expect = 1e-10 Identities = 53/201 (26%), Positives = 84/201 (41%), Gaps = 15/201 (7%) Query: 254 GSHVSLLCGADSNPPPLLTWMRDGTVLREAVAES---LLLELEEVTPAEDGVYACLAENA 310 G + L C A +P P + W + + E V+E L+ V+ + G Y C AEN Sbjct: 2861 GDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENR 2920 Query: 311 YGQDNRTVGLSVMYAPWKPTVNGT----MVAVEGETVSILCSTQSNPDPILTIFKEKQIL 366 G RT +S ++ P + G +V G ++ + C + +P P + K+ L Sbjct: 2921 VG---RTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPL 2977 Query: 367 STVIYESELQ---LELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAA 423 +LQ L + +D G Y C+AEN+ G L ++ APV +E Sbjct: 2978 RGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMT 3037 Query: 424 AR--DTVQCLCVVKSNPEPSV 442 R D V C P P++ Sbjct: 3038 VRSGDDVALRCQATGEPTPTI 3058 Score = 65.1 bits (157), Expect = 2e-10 Identities = 80/322 (24%), Positives = 123/322 (38%), Gaps = 43/322 (13%) Query: 150 VAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVS----LLHFV 205 + G +E+ C + P + WL + G PA +E VQV+ LH Sbjct: 420 IVGQPLELPCQASGSPV---PTIQWLQN---GRPA-------EELAGVQVASQGTTLHID 466 Query: 206 PTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEM-----------NSSVEAIEG 254 + CQA+ T E S+ ++ P ++E+ +SS A Sbjct: 467 HVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACD 526 Query: 255 SHVSLLCGADSNPPPLLTWMRDGTVLREA----VAESLL--LELEEVTPAEDGVYACLAE 308 V GA PP + W G++ E VA SL L++E+V ++G+Y C A Sbjct: 527 PPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAAT 586 Query: 309 NAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILS- 367 N G+ R V L V+ P +E +V++ C P P ++ FK Q +S Sbjct: 587 NLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSS 646 Query: 368 ----TVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHC-- 421 TV + + L + D G Y CVA N G + L V P + L Sbjct: 647 WMGVTVSVDGRV-LRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPG 705 Query: 422 -AAARDTVQCLCVVKSNPEPSV 442 V+ C P P++ Sbjct: 706 PVLVNTPVRLTCNATGAPSPTL 727 Score = 64.7 bits (156), Expect = 2e-10 Identities = 62/248 (25%), Positives = 96/248 (38%), Gaps = 51/248 (20%) Query: 239 PPVIVE--MNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVL---------------- 280 PP I E ++V + G ++L C A+ P P + W++D ++ Sbjct: 16 PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWG 75 Query: 281 ----REAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMV 336 + E L + + G+Y+C AEN G R L V+ P +V G Sbjct: 76 QVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPP---SVLGAGA 132 Query: 337 AVE-----GETVSILCSTQSNPDPILTIFKEKQIL-----STVIYESELQLELPAVSPED 386 A E G V + C T P P + K++Q + + E L + D Sbjct: 133 AQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGD 192 Query: 387 DGEYWCVAENQYGQRATAFNLSVEFAP----------VLLLESHCAAARDTVQCLCVVKS 436 +G Y CVA + GQ+A F L V P V ++E H VQ LC + Sbjct: 193 EGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDH------LVQLLCEARG 246 Query: 437 NPEPSVAF 444 P P++ + Sbjct: 247 VPTPNITW 254 Score = 59.3 bits (142), Expect = 1e-08 Identities = 81/332 (24%), Positives = 128/332 (38%), Gaps = 54/332 (16%) Query: 148 EVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPT 207 + VAG V + C+ + P LSW HEGL E +G S+L Sbjct: 325 KAVAGRPVALECVARGHPS---PTLSW-HHEGLPVAESNESRLETDG-----SVLRLESP 375 Query: 208 REANGHRLGCQASFP--NTTLQFEGYASMDVKYPP--VIVEMNSSVEAIEGSHVSLLCGA 263 EA+ C AS P LQ+ S++V+ PP ++ E V I G + L C A Sbjct: 376 GEASSGLYSCVASSPAGEAVLQY----SVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQA 431 Query: 264 DSNPPPLLTWMRDGTVLRE-----AVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTV 318 +P P + W+++G E ++ L ++ V G++AC A N G V Sbjct: 432 SGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEV 491 Query: 319 GLSVMYAPWKPTVNGTMVA------VEGETVSILCSTQ------SNPDPIL--------T 358 +SV + W P V + + C ++P P L + Sbjct: 492 EVSV-HGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGS 550 Query: 359 IFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQ--RATAFNL----SVEFA 412 ++ E + V Y L++ V D+G Y C A N G+ R A + ++E Sbjct: 551 LWGEPTGI-PVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPG 609 Query: 413 PVLLLESHCAAARDTVQCLCVVKSNPEPSVAF 444 PV + +V C+ P P V++ Sbjct: 610 PV----NKAVLENASVTLECLASGVPPPDVSW 637 Score = 58.2 bits (139), Expect = 2e-08 Identities = 68/255 (26%), Positives = 102/255 (40%), Gaps = 24/255 (9%) Query: 170 PELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFE 229 P + W ++ P G +D G+ +Q + + +RE +G + C A N + + Sbjct: 2876 PRIGWTVND---RPVTEGVSEQDGGSTLQRAAV----SREDSGTYV-CWAE--NRVGRTQ 2925 Query: 230 GYASMDVKYPPVIVEMNSS--VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAES 287 + + VK PV+ S VE + GS + L C +P P + W++DG LR + Sbjct: 2926 AVSFVHVKEAPVLQGEAFSYLVEPVGGS-IQLDCVVRGDPVPDIHWIKDGLPLRGSHLRH 2984 Query: 288 LL----LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETV 343 L L + + G Y CLAEN G + V L + AP M G+ V Sbjct: 2985 QLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDV 3044 Query: 344 SILCSTQSNPDPILTIFKEKQILST-----VIYESELQLELPAVSPEDDGEYWCVAENQY 398 ++ C P P + + Q L + + L LE V D G Y CVA N Sbjct: 3045 ALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLE--NVETGDAGTYDCVAHNLL 3102 Query: 399 GQRATAFNLSVEFAP 413 G L V P Sbjct: 3103 GSATARAFLVVRGEP 3117 Score = 52.8 bits (125), Expect = 1e-06 Identities = 54/231 (23%), Positives = 83/231 (35%), Gaps = 13/231 (5%) Query: 239 PPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAE-------SLLLE 291 PP I S++ + L C A +P PL+ W +DG L + + S L Sbjct: 2481 PPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALL 2540 Query: 292 LEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQS 351 L P + + C+ N G+ +R ++V P V + C + Sbjct: 2541 LTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTG 2600 Query: 352 NPDPILTIFKEKQIL----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNL 407 P P ++ K L S LE+ P G Y C A N G L Sbjct: 2601 IPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFL 2660 Query: 408 SVEFAPVL--LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNES 456 +V+ +PV+ L A A + V C P P++ ++ NV S Sbjct: 2661 TVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVS 2711 >gi|130979981 CD33 antigen isoform 1 precursor [Homo sapiens] Length = 364 Score = 93.6 bits (231), Expect = 5e-19 Identities = 75/249 (30%), Positives = 101/249 (40%), Gaps = 23/249 (9%) Query: 1 MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFP----DELRPAVVH 56 M L LPL W A W + S++ EG CV +PC F P D+ P VH Sbjct: 1 MPLLLLLPLLWAGALAMDPNFW-LQVQESVTVQEGLCVLVPCTFFHPIPYYDKNSP--VH 57 Query: 57 GVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYY 116 G W+ PV Q V E QGR RLLGD NC+L + + G Y+ Sbjct: 58 GYWFREGAIISRDSPVATNKLDQEVQEETQGRFRLLGDPSRNNCSLSIVDARRRDNGSYF 117 Query: 117 FRGDLG----GYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPEL 172 FR + G Y S H V D+ + P I++P + G ++C V C + P + Sbjct: 118 FRMERGSTKYSYKSPQLSVH-VTDLTHRPKILIPGTLEPGHSKNLTCSVSWACEQGTPPI 176 Query: 173 -SWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGY 231 SWL P LG S+L P + +G L CQ F + E Sbjct: 177 FSWLS----AAPTSLG------PRTTHSSVLIITPRPQDHGTNLTCQVKFAGAGVTTERT 226 Query: 232 ASMDVKYPP 240 ++V Y P Sbjct: 227 IQLNVTYVP 235 >gi|109150416 peroxidasin [Homo sapiens] Length = 1479 Score = 90.1 bits (222), Expect = 5e-18 Identities = 103/384 (26%), Positives = 151/384 (39%), Gaps = 45/384 (11%) Query: 141 PNIVVPPE---VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLRE-DEGTW 196 P I P+ V +G V +C N +PE+ WL + RL D+GT Sbjct: 246 PRITSEPQDADVTSGNTVYFTCRAEGNP---KPEIIWLRNNNELSMKTDSRLNLLDDGT- 301 Query: 197 VQVSLLHFVPTREANGHRLGCQAS-------FPNTTLQFEGYASMDVKYPPVIVEMNSSV 249 L T+E + C A TL++ G + P V + Sbjct: 302 -----LMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPAR-----PTFVIQPQNT 351 Query: 250 EAIEGSHVSLLCGADSNPPPLLTWMR-DGTVL----REAVAESLLLELEEVTPAEDGVYA 304 E + G V+L C A +PPP ++W R D T L R + S L ++ V + G YA Sbjct: 352 EVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYA 411 Query: 305 CLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQ 364 C A N + T + V P V +EG+TV C + NP P++ K Sbjct: 412 CSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGS 471 Query: 365 ILST---VIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVE--FAPVL--LL 417 LS + S L + V+ D G+Y C A N G + +L+V+ PV + Sbjct: 472 QLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIP 531 Query: 418 ESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLR 477 VQ C + PEP++ + V V ES + F S L + + Sbjct: 532 SDTTVEVGANVQLPCSSQGEPEPAITWN--KDGVQVTESGK-FHISPEGFLTINDV---- 584 Query: 478 GQAQAPPRVICTARNLYGAKSLEL 501 G A A R C ARN G+ S+ + Sbjct: 585 GPADA-GRYECVARNTIGSASVSM 607 Score = 74.7 bits (182), Expect = 2e-13 Identities = 73/287 (25%), Positives = 109/287 (37%), Gaps = 25/287 (8%) Query: 141 PNIVVPP---EVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPA-VLGRLREDEGTW 196 P V+ P EV+ G V + C + P P +SW + P + G + Sbjct: 342 PTFVIQPQNTEVLVGESVTLECSATGHPP---PRISWTRGDRTPLPVDPRVNITPSGGLY 398 Query: 197 VQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSH 256 +Q + + + C A+ N A + V+ P IEG Sbjct: 399 IQNVV-------QGDSGEYACSAT--NNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQT 449 Query: 257 VSLLCGADSNPPPLLTWMRDGTVL----REAVAESLLLELEEVTPAEDGVYACLAENAYG 312 V C A NPPP++ W + G+ L R V S L + V + G Y C A N G Sbjct: 450 VDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIG 509 Query: 313 QDNRTVGLSVM--YAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEK-QILSTV 369 L+V P ++ G V + CS+Q P+P +T K+ Q+ + Sbjct: 510 SQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESG 569 Query: 370 IYESELQ--LELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPV 414 + + L + V P D G Y CVA N G + + LSV V Sbjct: 570 KFHISPEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSVNVPDV 616 >gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] Length = 1215 Score = 87.8 bits (216), Expect = 3e-17 Identities = 93/374 (24%), Positives = 151/374 (40%), Gaps = 29/374 (7%) Query: 137 IVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTW 196 +V PN+ V P G +SC V P L+W+ + PA GR+ + Sbjct: 403 LVPAPNVTVSP----GETAVLSCRVLGEAPY---NLTWV-RDWRVLPASTGRVAQLADLS 454 Query: 197 VQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSH 256 +++S + +PT +G R C AS N + + + V+ P + SS +G Sbjct: 455 LEISGI--IPT---DGGRYQCVASNANGVTRASVW--LLVREAPQVSIHTSSQHFSQGVE 507 Query: 257 VSLLCGADSNPPPLLTWMRDGTVLREA----VAESLLLELEEVTPAEDGVYACLAENAYG 312 V + C A P P ++W R+ L+E V L ++ V P + G Y+C A N G Sbjct: 508 VKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVG 567 Query: 313 QDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFK-EKQILSTVIY 371 D TV L P VN ++ GE ++C P P + ++ +++ Sbjct: 568 TDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEG 627 Query: 372 ESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVL--LLESHCAAARDTVQ 429 S +L +PA D G Y C A N+ G + L+V AP L L + Sbjct: 628 SSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSAL 687 Query: 430 CLCVVKSNPEPSVAF---ELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQAQAPPRV 486 C P P+V + + + + SG++ ++ + QAP Sbjct: 688 LACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFE--SVAPEDQAP--Y 743 Query: 487 ICTARNLYGAKSLE 500 +C ARN++G E Sbjct: 744 VCEARNVFGKVQAE 757 Score = 76.3 bits (186), Expect = 8e-14 Identities = 95/371 (25%), Positives = 134/371 (36%), Gaps = 34/371 (9%) Query: 149 VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTR 208 V G ++C P P ++W +G LG R +L F Sbjct: 680 VELGRSALLACRATGRPP---PTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVA 736 Query: 209 EANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPP 268 + C+A +Q E + PP I +V +EG VSL C + P Sbjct: 737 PEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRP 796 Query: 269 -PLLTWMRDGTVL----REAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVM 323 P W++DG L R ++ L L+ G Y+C+A N G +R V L V Sbjct: 797 LPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQ 856 Query: 324 YAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILST------VIYESELQL 377 P + EG S+ C P P +T KE L++ V E L + Sbjct: 857 VPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLI 916 Query: 378 ELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESH---------CAAARDTV 428 P S +D G Y C A N G + LSV P + + A A + V Sbjct: 917 AQP--SAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEV 974 Query: 429 QCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTL-RGQAQAPPRVI 487 C K +P P V + SR V + R GL+ + L L + Q Sbjct: 975 TLDCEAKGSPPPLVTWTKDSRPVP--------PITNRYGLLPSGSLRLAQVQVGDSGHYE 1026 Query: 488 CTARNLYGAKS 498 CTA N G+ S Sbjct: 1027 CTASNPAGSAS 1037 Score = 74.3 bits (181), Expect = 3e-13 Identities = 55/176 (31%), Positives = 77/176 (43%), Gaps = 8/176 (4%) Query: 232 ASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVL-----REAVAE 286 A + V PP + +V G L C P LTW+RD VL R A Sbjct: 392 AQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLA 451 Query: 287 SLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSIL 346 L LE+ + P + G Y C+A NA G +V L V AP + +G V + Sbjct: 452 DLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVS 511 Query: 347 CSTQSNPDPILTIFKEKQIL---STVIYESELQLELPAVSPEDDGEYWCVAENQYG 399 CS P P ++ +E Q L S + +++ L + V+PED G Y C A N+ G Sbjct: 512 CSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVG 567 Score = 68.6 bits (166), Expect = 2e-11 Identities = 71/279 (25%), Positives = 110/279 (39%), Gaps = 29/279 (10%) Query: 149 VVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTR 208 V+ G V + C+V P PE WL P +R D LH Sbjct: 779 VLEGQPVSLPCIVLAGRP--LPERHWLKDGRPLPPGSRHSIRADGS-------LHLDRAL 829 Query: 209 EANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPP 268 + + R C A+ NT + V+ PP I + EG SL C A P Sbjct: 830 QEHAGRYSCVAT--NTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPA 887 Query: 269 PLLTWMRDGTVLREA-----VAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVM 323 P +TW ++ L V++ L + + + + G Y C A N G ++ + LSV Sbjct: 888 PTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVN 947 Query: 324 YAPWKPTVNGT--------MVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESEL 375 P + +NG+ + A GE V++ C + +P P++T K+ + + + L Sbjct: 948 TKP-RIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGL 1006 Query: 376 ----QLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVE 410 L L V D G Y C A N G + + L V+ Sbjct: 1007 LPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQ 1045 Score = 48.1 bits (113), Expect = 2e-05 Identities = 40/165 (24%), Positives = 65/165 (39%), Gaps = 6/165 (3%) Query: 291 ELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQ 350 E+ + AE+G Y C A + G + V P + + GET + C Sbjct: 365 EILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL 424 Query: 351 SNPDPILTIFKEKQIL----STVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFN 406 LT ++ ++L V ++L LE+ + P D G Y CVA N G + Sbjct: 425 GEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVW 484 Query: 407 LSVEFAPVLLL--ESHCAAARDTVQCLCVVKSNPEPSVAFELPSR 449 L V AP + + S + V+ C P P +++ S+ Sbjct: 485 LLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQ 529 Score = 44.7 bits (104), Expect = 3e-04 Identities = 29/87 (33%), Positives = 39/87 (44%), Gaps = 6/87 (6%) Query: 249 VEAIEGSHVSLLCGADSNPPPLLTWMRDGTVL-----REAVAESLLLELEEVTPAEDGVY 303 V A G V+L C A +PPPL+TW +D + R + S L L +V + G Y Sbjct: 966 VTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHY 1025 Query: 304 ACLAENAYGQDNRTVGLSVM-YAPWKP 329 C A N G + L V W+P Sbjct: 1026 ECTASNPAGSASHRYVLGVQGRTSWQP 1052 >gi|4507875 vascular cell adhesion molecule 1 isoform a precursor [Homo sapiens] Length = 739 Score = 86.7 bits (213), Expect = 6e-17 Identities = 95/366 (25%), Positives = 152/366 (41%), Gaps = 31/366 (8%) Query: 74 FKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYNQYTFSEHS 133 F RTQ+ G+ R G N TL LS VS E Y G + Sbjct: 345 FSWRTQI-DSPLSGKVRSEGT----NSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVE 399 Query: 134 VLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDE 193 + P I + +V G+ V VSC VP P R E+ L E + E + + Sbjct: 400 LYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMK 459 Query: 194 GTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEG---------YASMDVKYPPVIVE 244 + + F+PT E G L CQA ++FE Y ++ + V+V Sbjct: 460 SLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVS 519 Query: 245 MNSSVEAIEGSHVSLLCGADSNPPPLLTWMR---DGTVLREAVAESLLLELEEVTPAEDG 301 +S +E EGS V++ C + P P + W R +G + + ++E+ L L + G Sbjct: 520 PSSILE--EGSSVNMTCLSQGFPAPKILWSRQLPNGEL--QPLSENATLTLISTKMEDSG 575 Query: 302 VYACLAENAYGQDNRTVGLSVMYAPW--KPTVNGTMVAVEGETVSILCSTQSNPDPILTI 359 VY C N G+ + V L + P K T + EG+TV I C+ + P+ + + Sbjct: 576 VYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIIL 635 Query: 360 FKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVE--------F 411 K+ + TV+ + + +D G Y C ++N+ G + + L V+ F Sbjct: 636 KKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYF 695 Query: 412 APVLLL 417 +P LL+ Sbjct: 696 SPELLV 701 Score = 51.6 bits (122), Expect = 2e-06 Identities = 51/227 (22%), Positives = 93/227 (40%), Gaps = 14/227 (6%) Query: 141 PNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVS 200 P I + + AG + V C V D P R E+ L + L + + + + Sbjct: 119 PEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSL 178 Query: 201 LLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPV-------IVEMNSSVEAIE 253 + F P E G L C+A + VK V ++ +N S + E Sbjct: 179 EVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQE 238 Query: 254 GSHVSLLCGADSNPPPLLTWMR---DGTVLREAVAESLLLELEEVTPAEDGVYACLAENA 310 G V++ C ++ P P + W + +G + + ++ + L L + + G+Y C N Sbjct: 239 GGSVTMTCSSEGLPAPEIFWSKKLDNGNL--QHLSGNATLTLIAMRMEDSGIYVCEGVNL 296 Query: 311 YGQDNRTVGLSVMYAPWKPTVN-GTMVAVE-GETVSILCSTQSNPDP 355 G++ + V L V P+ ++ G +A + G++V + CS P Sbjct: 297 IGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESP 343 Score = 34.7 bits (78), Expect = 0.27 Identities = 31/119 (26%), Positives = 48/119 (40%), Gaps = 4/119 (3%) Query: 330 TVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGE 389 +VN + EG +V++ CS++ P P + K+ + L L A+ ED G Sbjct: 229 SVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGI 288 Query: 390 YWCVAENQYGQRATAFNLSVEFAPVLLLESH----CAAARDTVQCLCVVKSNPEPSVAF 444 Y C N G+ L V+ P + S A D+V C V PS ++ Sbjct: 289 YVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSW 347 >gi|18201909 vascular cell adhesion molecule 1 isoform b precursor [Homo sapiens] Length = 647 Score = 85.5 bits (210), Expect = 1e-16 Identities = 91/342 (26%), Positives = 147/342 (42%), Gaps = 28/342 (8%) Query: 99 NCTLLLSNVSPELGGKYYFRG-DLGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEV 157 N TL L + E G Y G +L G N+ E V P I + +V G+ V V Sbjct: 273 NATLTLIAMRMEDSGIYVCEGVNLIGKNRKEV-ELIVQAFPRDPEIEMSGGLVNGSSVTV 331 Query: 158 SCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGC 217 SC VP P R E+ L E + E + + + + F+PT E G L C Sbjct: 332 SCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVC 391 Query: 218 QASFPNTTLQFEG---------YASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPP 268 QA ++FE Y ++ + V+V +S +E EGS V++ C + P Sbjct: 392 QAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILE--EGSSVNMTCLSQGFPA 449 Query: 269 PLLTWMR---DGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYA 325 P + W R +G + + ++E+ L L + GVY C N G+ + V L + Sbjct: 450 PKILWSRQLPNGEL--QPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVT 507 Query: 326 PW--KPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVS 383 P K T + EG+TV I C+ + P+ + + K+ + TV+ + + Sbjct: 508 PKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQ 567 Query: 384 PEDDGEYWCVAENQYGQRATAFNLSVE--------FAPVLLL 417 +D G Y C ++N+ G + + L V+ F+P LL+ Sbjct: 568 LKDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLV 609 Score = 54.7 bits (130), Expect = 3e-07 Identities = 111/506 (21%), Positives = 197/506 (38%), Gaps = 61/506 (12%) Query: 141 PNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVS 200 P I + + AG + V C V D P R E+ L + L + + + + Sbjct: 119 PEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSL 178 Query: 201 LLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPV-------IVEMNSSVEAIE 253 + F P E G L C+A + VK V ++ +N S + E Sbjct: 179 EVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQE 238 Query: 254 GSHVSLLCGADSNPPPLLTWMR---DGTVLREAVAESLLLELEEVTPAEDGVYACLAENA 310 G V++ C ++ P P + W + +G + + ++ + L L + + G+Y C N Sbjct: 239 GGSVTMTCSSEGLPAPEIFWSKKLDNGNL--QHLSGNATLTLIAMRMEDSGIYVCEGVNL 296 Query: 311 YGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPI----LTIFKEKQIL 366 G++ + V L V P P + + V G +V++ C S P+ + + K + IL Sbjct: 297 IGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPS-VYPLDRLEIELLKGETIL 355 Query: 367 STVIYESELQLE-----------LPAVSPEDDGE-YWCVA-------ENQYGQRATAFNL 407 + + + ++ +P + ED G+ C A E + QR + L Sbjct: 356 ENIEFLEDTDMKSLENKSLEMTFIPTI--EDTGKALVCQAKLHIDDMEFEPKQRQSTQTL 413 Query: 408 SVEFAP----VLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYS 463 V AP VL+ S +V C+ + P P + L SR + E + S Sbjct: 414 YVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKI---LWSRQLPNGELQ---PLS 467 Query: 464 ERSGLVLTSILTLRGQAQAPPRVICTARNLYG--AKSLELPFQGAHRLMWAKIGPVGAV- 520 E + L L S + + +C N G K +EL Q + + P +V Sbjct: 468 ENATLTLIST-----KMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVK 522 Query: 521 VAFAILIAIVC-YITQT---RRKKNVTESPSFSAGDNPPVLFSSDFRISGAPEKYESERR 576 ++I+ C + +T +KK T + D + + + +G E ES+ + Sbjct: 523 EGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYE-CESKNK 581 Query: 577 LGSERRLLGLRGEPPELDLSYSHSDL 602 +GS+ R L L + E + Y +L Sbjct: 582 VGSQLRSLTLDVQGRENNKDYFSPEL 607 >gi|145275174 kin of IRRE-like 2 isoform c [Homo sapiens] Length = 708 Score = 85.1 bits (209), Expect = 2e-16 Identities = 122/467 (26%), Positives = 179/467 (38%), Gaps = 44/467 (9%) Query: 142 NIVVPPE---VVAGTEVEVSCMVPDNCP-------ELRPELSWLGHEGLGEPAVLGRLRE 191 +++VPPE V+ G V + VP N PEL W L + A + Sbjct: 118 HVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLL 177 Query: 192 DEGTWVQV-SLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVE 250 EGT V S L P +G C+A + ++ ++YPP + S Sbjct: 178 KEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHT 237 Query: 251 AIEGSHVSLLCGADSNPPPL-LTWMRDGTVLREAVAESLLLELEEVTPAEDGVYACLAEN 309 EG V LC A + PP W + G+ + A L + + E +C N Sbjct: 238 VQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEP--VSCEVSN 295 Query: 310 AYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTV 369 A G NR+ L V++ P + GE S C+ + NP P +T + Sbjct: 296 AVGSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG---GAQ 352 Query: 370 IYESELQLELPAVSPEDDGEYWCVAE-NQYGQR--ATAFNLSVEFAPVL-LLESHCAAAR 425 + S L LP+V PED G+Y C AE G R A L+V PV+ L S A R Sbjct: 353 VLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLR 412 Query: 426 DTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVY------SERSGL--VLTSILTLR 477 + C+V ++P P S+ F+ R GL L S+L + Sbjct: 413 GPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHIS 472 Query: 478 G--QAQAPPRVICTARNLYGAKSLELPFQGAHRLMWAKI--GPVGAVVAFAILI---AIV 530 G ++ C+ARN G + L +I G A ++I A+ Sbjct: 473 GTQESDFSRSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALC 532 Query: 531 CYITQTRRKKNVTESPSFSAGDN-PPVLFSSDFRISGAPEKYESERR 576 C+ ++ S SFS N + SSD S PE+ E+ R Sbjct: 533 CW-------RHSKASASFSEQKNLMRIPGSSDGSSSRGPEEEETGSR 572 >gi|145275172 kin of IRRE-like 2 isoform b [Homo sapiens] Length = 583 Score = 85.1 bits (209), Expect = 2e-16 Identities = 122/467 (26%), Positives = 179/467 (38%), Gaps = 44/467 (9%) Query: 142 NIVVPPE---VVAGTEVEVSCMVPDNCP-------ELRPELSWLGHEGLGEPAVLGRLRE 191 +++VPPE V+ G V + VP N PEL W L + A + Sbjct: 68 HVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLL 127 Query: 192 DEGTWVQV-SLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVE 250 EGT V S L P +G C+A + ++ ++YPP + S Sbjct: 128 KEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHT 187 Query: 251 AIEGSHVSLLCGADSNPPPL-LTWMRDGTVLREAVAESLLLELEEVTPAEDGVYACLAEN 309 EG V LC A + PP W + G+ + A L + + E +C N Sbjct: 188 VQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEP--VSCEVSN 245 Query: 310 AYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTV 369 A G NR+ L V++ P + GE S C+ + NP P +T + Sbjct: 246 AVGSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG---GAQ 302 Query: 370 IYESELQLELPAVSPEDDGEYWCVAE-NQYGQR--ATAFNLSVEFAPVL-LLESHCAAAR 425 + S L LP+V PED G+Y C AE G R A L+V PV+ L S A R Sbjct: 303 VLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLR 362 Query: 426 DTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVY------SERSGL--VLTSILTLR 477 + C+V ++P P S+ F+ R GL L S+L + Sbjct: 363 GPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHIS 422 Query: 478 G--QAQAPPRVICTARNLYGAKSLELPFQGAHRLMWAKI--GPVGAVVAFAILI---AIV 530 G ++ C+ARN G + L +I G A ++I A+ Sbjct: 423 GTQESDFSRSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALC 482 Query: 531 CYITQTRRKKNVTESPSFSAGDN-PPVLFSSDFRISGAPEKYESERR 576 C+ ++ S SFS N + SSD S PE+ E+ R Sbjct: 483 CW-------RHSKASASFSEQKNLMRIPGSSDGSSSRGPEEEETGSR 522 >gi|145275170 kin of IRRE-like 2 isoform a [Homo sapiens] Length = 633 Score = 85.1 bits (209), Expect = 2e-16 Identities = 122/467 (26%), Positives = 179/467 (38%), Gaps = 44/467 (9%) Query: 142 NIVVPPE---VVAGTEVEVSCMVPDNCP-------ELRPELSWLGHEGLGEPAVLGRLRE 191 +++VPPE V+ G V + VP N PEL W L + A + Sbjct: 118 HVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLL 177 Query: 192 DEGTWVQV-SLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVE 250 EGT V S L P +G C+A + ++ ++YPP + S Sbjct: 178 KEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHT 237 Query: 251 AIEGSHVSLLCGADSNPPPL-LTWMRDGTVLREAVAESLLLELEEVTPAEDGVYACLAEN 309 EG V LC A + PP W + G+ + A L + + E +C N Sbjct: 238 VQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEP--VSCEVSN 295 Query: 310 AYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTV 369 A G NR+ L V++ P + GE S C+ + NP P +T + Sbjct: 296 AVGSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG---GAQ 352 Query: 370 IYESELQLELPAVSPEDDGEYWCVAE-NQYGQR--ATAFNLSVEFAPVL-LLESHCAAAR 425 + S L LP+V PED G+Y C AE G R A L+V PV+ L S A R Sbjct: 353 VLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLR 412 Query: 426 DTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVY------SERSGL--VLTSILTLR 477 + C+V ++P P S+ F+ R GL L S+L + Sbjct: 413 GPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHIS 472 Query: 478 G--QAQAPPRVICTARNLYGAKSLELPFQGAHRLMWAKI--GPVGAVVAFAILI---AIV 530 G ++ C+ARN G + L +I G A ++I A+ Sbjct: 473 GTQESDFSRSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALC 532 Query: 531 CYITQTRRKKNVTESPSFSAGDN-PPVLFSSDFRISGAPEKYESERR 576 C+ ++ S SFS N + SSD S PE+ E+ R Sbjct: 533 CW-------RHSKASASFSEQKNLMRIPGSSDGSSSRGPEEEETGSR 572 >gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo sapiens] Length = 1248 Score = 83.6 bits (205), Expect = 5e-16 Identities = 99/376 (26%), Positives = 154/376 (40%), Gaps = 44/376 (11%) Query: 144 VVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEG-TWVQVSLL 202 V P EV G V + C P + LR + W+ + L +++DE T Q L Sbjct: 138 VKPVEVEEGESVVLPCNPPPSAEPLR--IYWMNSKIL-------HIKQDERVTMGQNGNL 188 Query: 203 HFVPTREANGHR-LGCQASFPNTT---------LQFEGYASMDVKYPPVIVEMNSS--VE 250 +F ++ H C A FP T L+ + SM + P ++ NSS + Sbjct: 189 YFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLV 248 Query: 251 AIEGSHVSLLCGADSNPPPLLTWMR-DGTVLREAVA---ESLLLELEEVTPAEDGVYACL 306 A++G + L C A+ P P + W+R G + + V + L+L +V +DG Y CL Sbjct: 249 ALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCL 308 Query: 307 AENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQIL 366 AEN+ G ++V AP+ + + GET + C Q P P +T + Sbjct: 309 AENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPV 368 Query: 367 STVIYESELQLE-----LPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLL---- 417 + + + +++ L V P D C A N++G + V P +L Sbjct: 369 EELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADN 428 Query: 418 ESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLR 477 +++ A T LC P PSV + L TV + ER F Y+ L +R Sbjct: 429 QTYMAVQGSTAYLLCKAFGAPVPSVQW-LDEDGTTVLQDERFFPYA-------NGTLGIR 480 Query: 478 G-QAQAPPRVICTARN 492 QA R C A N Sbjct: 481 DLQANDTGRYFCLAAN 496 Score = 65.1 bits (157), Expect = 2e-10 Identities = 48/167 (28%), Positives = 82/167 (49%), Gaps = 13/167 (7%) Query: 335 MVAVEGETVSILCSTQSNPDPILTIFKEKQILST--VIYESELQ-LELPAVSPEDDGEYW 391 +VA++G+ + + C + P P + + + V Y++ + L+L V EDDGEY Sbjct: 247 LVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYR 306 Query: 392 CVAENQYGQRATAFNLSVEFAPVLL--LESHCAAARDTVQCLCVVKSNPEPSVAFELPSR 449 C+AEN G A+ ++VE AP L +SH +T + C V+ P+P V + + Sbjct: 307 CLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRI--N 364 Query: 450 NVTVNESEREFVYS-ERSGLVLTSILTLRGQAQAPPRVICTARNLYG 495 + V E ++ Y +R L+L+++ Q C ARN +G Sbjct: 365 GIPVEELAKDQKYRIQRGALILSNV-----QPSDTMVTQCEARNRHG 406 Score = 52.8 bits (125), Expect = 1e-06 Identities = 59/241 (24%), Positives = 95/241 (39%), Gaps = 27/241 (11%) Query: 254 GSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLL------LELEEVTPAEDGVYACLA 307 G L C P P +TW +G + E + L L V P++ V C A Sbjct: 342 GETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEA 401 Query: 308 ENAYGQDNRTVGLSVMYAPWKPTV--NGTMVAVEGETVSILCSTQSNPDPILTIFKEKQI 365 N +G + V+ P K N T +AV+G T +LC P P + E Sbjct: 402 RNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDG- 460 Query: 366 LSTVIYESEL------QLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFA------P 413 +TV+ + L + + D G Y+C+A N NL V+ A P Sbjct: 461 -TTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGP 519 Query: 414 VLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNV-TVNESEREFVYSERSGLVLTS 472 +E +R T C + +PS+ + R++ + +S++ F+ E LV+ S Sbjct: 520 RSTIEK--KGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFI--EDGRLVIHS 575 Query: 473 I 473 + Sbjct: 576 L 576 Score = 40.4 bits (93), Expect = 0.005 Identities = 57/247 (23%), Positives = 88/247 (35%), Gaps = 37/247 (14%) Query: 239 PPVIVEMNSS-VEAIEGSHVSLLCGADSNPPPLLTWMRDG-----------TVLREAVAE 286 PPVI E + + +SL C A P W RDG TV + + Sbjct: 29 PPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSG 88 Query: 287 SLLLELEEVTPAE--DGVYACLAENAYGQD-NRTVGLSVMYAP-WKPTVNGTMVAVEGET 342 S + A+ G+Y C A N G + + L AP W + EGE+ Sbjct: 89 SFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGES 148 Query: 343 VSILCSTQSNPDPILTIFKEKQIL-----STVIYESELQLELPAVSPEDD-GEYWC---- 392 V + C+ + +P+ + +IL V L V D+ +Y C Sbjct: 149 VVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHF 208 Query: 393 ------VAENQYGQRATAFNLSVEFAPVLLL----ESHCAAARDTVQCL-CVVKSNPEPS 441 + + R A N ++ P LL SH A + L C+ + P P+ Sbjct: 209 PGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPT 268 Query: 442 VAFELPS 448 + + PS Sbjct: 269 IKWLRPS 275 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.318 0.135 0.411 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 26,332,778 Number of Sequences: 37866 Number of extensions: 1258121 Number of successful extensions: 6313 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 202 Number of HSP's successfully gapped in prelim test: 190 Number of HSP's that attempted gapping in prelim test: 2970 Number of HSP's gapped (non-prelim): 1760 length of query: 626 length of database: 18,247,518 effective HSP length: 108 effective length of query: 518 effective length of database: 14,157,990 effective search space: 7333838820 effective search space used: 7333838820 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.