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Search of human proteins with 110815834
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110815834 F-box and WD-40 domain protein 10 [Homo sapiens]
(1051 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110815834 F-box and WD-40 domain protein 10 [Homo sapiens] 2128 0.0
gi|157694487 CMT1A duplicated region transcript 1 [Homo sapiens] 1363 0.0
gi|239756740 PREDICTED: similar to CMT1A duplicated region trans... 761 0.0
gi|169210888 PREDICTED: similar to FBXW10 protein [Homo sapiens] 474 e-133
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 125 2e-28
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 125 2e-28
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 125 2e-28
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 99 2e-20
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 99 2e-20
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 99 2e-20
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 96 2e-19
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 96 2e-19
gi|16554629 WD repeat domain 5 [Homo sapiens] 91 4e-18
gi|16554627 WD repeat domain 5 [Homo sapiens] 91 4e-18
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 91 6e-18
gi|23199987 WD repeat domain 5B [Homo sapiens] 91 6e-18
gi|157266266 WD repeat domain 86 [Homo sapiens] 86 1e-16
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 81 5e-15
gi|21071067 TBP-associated factor 5 [Homo sapiens] 81 5e-15
gi|19913369 transducin beta-like 3 [Homo sapiens] 79 3e-14
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 77 1e-13
gi|32189425 WD repeat domain 69 [Homo sapiens] 76 1e-13
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 75 3e-13
gi|18874090 WD repeat domain 48 [Homo sapiens] 74 7e-13
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 74 9e-13
gi|113865883 WD repeat domain 38 [Homo sapiens] 72 2e-12
gi|4759276 RNA, U3 small nucleolar interacting protein 2 [Homo s... 71 6e-12
gi|45594312 TNF receptor-associated factor 7 [Homo sapiens] 70 1e-11
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 70 1e-11
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 69 2e-11
>gi|110815834 F-box and WD-40 domain protein 10 [Homo sapiens]
Length = 1051
Score = 2128 bits (5515), Expect = 0.0
Identities = 1051/1051 (100%), Positives = 1051/1051 (100%)
Query: 1 MENLESRLKNAPYFRCEKGTDSIPLCRKCETCVLAWKIFSTKEWFCRINDISQRRFLVGI 60
MENLESRLKNAPYFRCEKGTDSIPLCRKCETCVLAWKIFSTKEWFCRINDISQRRFLVGI
Sbjct: 1 MENLESRLKNAPYFRCEKGTDSIPLCRKCETCVLAWKIFSTKEWFCRINDISQRRFLVGI 60
Query: 61 LKQLNSLYLLHYFQNILQTTQGKDFIYNRSRINLSKKEGKVVKSSLNQMLDKTVEQKMKE 120
LKQLNSLYLLHYFQNILQTTQGKDFIYNRSRINLSKKEGKVVKSSLNQMLDKTVEQKMKE
Sbjct: 61 LKQLNSLYLLHYFQNILQTTQGKDFIYNRSRINLSKKEGKVVKSSLNQMLDKTVEQKMKE 120
Query: 121 ILYWFANSTQWTKANYTLLLLQMCNPKLLLTAANVIRVLFLREENNISGLNQDITDVCFS 180
ILYWFANSTQWTKANYTLLLLQMCNPKLLLTAANVIRVLFLREENNISGLNQDITDVCFS
Sbjct: 121 ILYWFANSTQWTKANYTLLLLQMCNPKLLLTAANVIRVLFLREENNISGLNQDITDVCFS 180
Query: 181 PEKDHSSKSATSQVYWTAKTQHTSLPLSKAPENEHLLGAASNPEEPWRNSLRCISEMNRL 240
PEKDHSSKSATSQVYWTAKTQHTSLPLSKAPENEHLLGAASNPEEPWRNSLRCISEMNRL
Sbjct: 181 PEKDHSSKSATSQVYWTAKTQHTSLPLSKAPENEHLLGAASNPEEPWRNSLRCISEMNRL 240
Query: 241 FSGKGDITKPGYDPCNLLVDLDDIRDLSSGFSKYRDFIRYLPIHLSKYILRMLDRHTLNK 300
FSGKGDITKPGYDPCNLLVDLDDIRDLSSGFSKYRDFIRYLPIHLSKYILRMLDRHTLNK
Sbjct: 241 FSGKGDITKPGYDPCNLLVDLDDIRDLSSGFSKYRDFIRYLPIHLSKYILRMLDRHTLNK 300
Query: 301 CASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQGSYTRGIDPNYANKVSIPVPKMVDDGK 360
CASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQGSYTRGIDPNYANKVSIPVPKMVDDGK
Sbjct: 301 CASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQGSYTRGIDPNYANKVSIPVPKMVDDGK 360
Query: 361 SMRVKHPKWKLRTKNEYNLWTAYQNEETQQVLIEERNVFCGTYNVRILSDTWDQNRVIHY 420
SMRVKHPKWKLRTKNEYNLWTAYQNEETQQVLIEERNVFCGTYNVRILSDTWDQNRVIHY
Sbjct: 361 SMRVKHPKWKLRTKNEYNLWTAYQNEETQQVLIEERNVFCGTYNVRILSDTWDQNRVIHY 420
Query: 421 SGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYW 480
SGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYW
Sbjct: 421 SGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYW 480
Query: 481 DLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDPILAT 540
DLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDPILAT
Sbjct: 481 DLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDPILAT 540
Query: 541 RINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWS 600
RINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWS
Sbjct: 541 RINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWS 600
Query: 601 MVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRIYNFLNGNCMKVLKANGRGDPV 660
MVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRIYNFLNGNCMKVLKANGRGDPV
Sbjct: 601 MVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRIYNFLNGNCMKVLKANGRGDPV 660
Query: 661 LSFFIQGNRMVVNTESNVLMFQFEHIKWQYAVEKTKQKKNKEKEEEKEENSLMEILSKCN 720
LSFFIQGNRMVVNTESNVLMFQFEHIKWQYAVEKTKQKKNKEKEEEKEENSLMEILSKCN
Sbjct: 661 LSFFIQGNRMVVNTESNVLMFQFEHIKWQYAVEKTKQKKNKEKEEEKEENSLMEILSKCN 720
Query: 721 IQVHSPRESVSSKQTVIQELLPGKPPKSRVLLKPAKFSSAVLIEELQSQGKSKSPRRDDD 780
IQVHSPRESVSSKQTVIQELLPGKPPKSRVLLKPAKFSSAVLIEELQSQGKSKSPRRDDD
Sbjct: 721 IQVHSPRESVSSKQTVIQELLPGKPPKSRVLLKPAKFSSAVLIEELQSQGKSKSPRRDDD 780
Query: 781 VEKAQKQGQLETPGKLPSHPKKKSWKIPMSPDQFLLTVSALQHAHNSGEFAYPCRPQTEI 840
VEKAQKQGQLETPGKLPSHPKKKSWKIPMSPDQFLLTVSALQHAHNSGEFAYPCRPQTEI
Sbjct: 781 VEKAQKQGQLETPGKLPSHPKKKSWKIPMSPDQFLLTVSALQHAHNSGEFAYPCRPQTEI 840
Query: 841 TDVWGPSISYPRKVLNFKGKSIQRAVDRLRLSNPPIDVKRTSIPLEIQKLQPNLKISLHS 900
TDVWGPSISYPRKVLNFKGKSIQRAVDRLRLSNPPIDVKRTSIPLEIQKLQPNLKISLHS
Sbjct: 841 TDVWGPSISYPRKVLNFKGKSIQRAVDRLRLSNPPIDVKRTSIPLEIQKLQPNLKISLHS 900
Query: 901 PRVQSTIPQPMIIRSRFSGSLKGGDQVTSSIERAVCSTGPLTSMQVIKPNRMLAPQVGTA 960
PRVQSTIPQPMIIRSRFSGSLKGGDQVTSSIERAVCSTGPLTSMQVIKPNRMLAPQVGTA
Sbjct: 901 PRVQSTIPQPMIIRSRFSGSLKGGDQVTSSIERAVCSTGPLTSMQVIKPNRMLAPQVGTA 960
Query: 961 TLSLKKERPRIYTALDPFRVNTEFVLLTVKEEKEHQEAKMKEYQARESTGVVDPGKVSKA 1020
TLSLKKERPRIYTALDPFRVNTEFVLLTVKEEKEHQEAKMKEYQARESTGVVDPGKVSKA
Sbjct: 961 TLSLKKERPRIYTALDPFRVNTEFVLLTVKEEKEHQEAKMKEYQARESTGVVDPGKVSKA 1020
Query: 1021 AWIRKIKGLPIDNFTKQGKTAAPELGQNVFI 1051
AWIRKIKGLPIDNFTKQGKTAAPELGQNVFI
Sbjct: 1021 AWIRKIKGLPIDNFTKQGKTAAPELGQNVFI 1051
>gi|157694487 CMT1A duplicated region transcript 1 [Homo sapiens]
Length = 752
Score = 1363 bits (3528), Expect = 0.0
Identities = 663/672 (98%), Positives = 667/672 (99%)
Query: 1 MENLESRLKNAPYFRCEKGTDSIPLCRKCETCVLAWKIFSTKEWFCRINDISQRRFLVGI 60
MENLESRLKNAPYFRCEKGTDSIPLCRKCET VLAWKIFSTKEWFCRINDISQRRFLVGI
Sbjct: 1 MENLESRLKNAPYFRCEKGTDSIPLCRKCETRVLAWKIFSTKEWFCRINDISQRRFLVGI 60
Query: 61 LKQLNSLYLLHYFQNILQTTQGKDFIYNRSRINLSKKEGKVVKSSLNQMLDKTVEQKMKE 120
LKQLNSLYLLHYFQNILQTTQGKDFIYNRSRI+LSKKEGKVVKSSLNQMLDKTVEQKMKE
Sbjct: 61 LKQLNSLYLLHYFQNILQTTQGKDFIYNRSRIDLSKKEGKVVKSSLNQMLDKTVEQKMKE 120
Query: 121 ILYWFANSTQWTKANYTLLLLQMCNPKLLLTAANVIRVLFLREENNISGLNQDITDVCFS 180
ILYWFANSTQWTKANYTLLLLQMCNPKLLLTAANVIRVLFLREENNISGLNQDITDVCFS
Sbjct: 121 ILYWFANSTQWTKANYTLLLLQMCNPKLLLTAANVIRVLFLREENNISGLNQDITDVCFS 180
Query: 181 PEKDHSSKSATSQVYWTAKTQHTSLPLSKAPENEHLLGAASNPEEPWRNSLRCISEMNRL 240
PEKDHSSKSATSQVYWTAKTQHTSLPLSKAPENEH LGAASNPEEPWRNSLRCISEMNRL
Sbjct: 181 PEKDHSSKSATSQVYWTAKTQHTSLPLSKAPENEHFLGAASNPEEPWRNSLRCISEMNRL 240
Query: 241 FSGKGDITKPGYDPCNLLVDLDDIRDLSSGFSKYRDFIRYLPIHLSKYILRMLDRHTLNK 300
FSGK DITKPGYDPCNLLVDLDDIRDLSSGFSKYRDFIRYLPIHLSKYILRMLDRHTLNK
Sbjct: 241 FSGKADITKPGYDPCNLLVDLDDIRDLSSGFSKYRDFIRYLPIHLSKYILRMLDRHTLNK 300
Query: 301 CASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQGSYTRGIDPNYANKVSIPVPKMVDDGK 360
CASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQGSYTRGIDPNYANKVSIPVPKMVDDGK
Sbjct: 301 CASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQGSYTRGIDPNYANKVSIPVPKMVDDGK 360
Query: 361 SMRVKHPKWKLRTKNEYNLWTAYQNEETQQVLIEERNVFCGTYNVRILSDTWDQNRVIHY 420
SMRVKHPKWKLRTKNEYNLWTAYQNEETQQVL+EERNVFCGTYNVRILSDTWDQNRVIHY
Sbjct: 361 SMRVKHPKWKLRTKNEYNLWTAYQNEETQQVLMEERNVFCGTYNVRILSDTWDQNRVIHY 420
Query: 421 SGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYW 480
SGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYW
Sbjct: 421 SGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYW 480
Query: 481 DLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDPILAT 540
DLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDPILAT
Sbjct: 481 DLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDPILAT 540
Query: 541 RINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWS 600
RINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWS
Sbjct: 541 RINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWS 600
Query: 601 MVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRIYNFLNGNCMKVLKANGRGDPV 660
MVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRIYNF NGNCMKV+KANGRGDPV
Sbjct: 601 MVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRIYNFFNGNCMKVIKANGRGDPV 660
Query: 661 LSFFIQGNRMVV 672
LSFFIQGNR+ V
Sbjct: 661 LSFFIQGNRISV 672
>gi|239756740 PREDICTED: similar to CMT1A duplicated region
transcript 1 [Homo sapiens]
Length = 433
Score = 761 bits (1965), Expect = 0.0
Identities = 371/374 (99%), Positives = 371/374 (99%)
Query: 1 MENLESRLKNAPYFRCEKGTDSIPLCRKCETCVLAWKIFSTKEWFCRINDISQRRFLVGI 60
MENLESRLKNAPYFRCEKGTDS PLCRKCETCVLAWKIFSTKEWFCRINDISQRRFLVGI
Sbjct: 3 MENLESRLKNAPYFRCEKGTDSNPLCRKCETCVLAWKIFSTKEWFCRINDISQRRFLVGI 62
Query: 61 LKQLNSLYLLHYFQNILQTTQGKDFIYNRSRINLSKKEGKVVKSSLNQMLDKTVEQKMKE 120
LKQLNSLYLLHYFQNILQTTQGKDFIYNRSRINLSKKEGKVVKSSLNQMLDKTVEQKMKE
Sbjct: 63 LKQLNSLYLLHYFQNILQTTQGKDFIYNRSRINLSKKEGKVVKSSLNQMLDKTVEQKMKE 122
Query: 121 ILYWFANSTQWTKANYTLLLLQMCNPKLLLTAANVIRVLFLREENNISGLNQDITDVCFS 180
ILYWFANSTQWTKANYTLLLLQMCNPKLLLTAANVIRVLFLREENNISGLNQDITDVCFS
Sbjct: 123 ILYWFANSTQWTKANYTLLLLQMCNPKLLLTAANVIRVLFLREENNISGLNQDITDVCFS 182
Query: 181 PEKDHSSKSATSQVYWTAKTQHTSLPLSKAPENEHLLGAASNPEEPWRNSLRCISEMNRL 240
PEKDHSSKSATSQVYWTAKTQHTSLPLSKAPENEH LGAASNPEEPWRNSLRCISEMNRL
Sbjct: 183 PEKDHSSKSATSQVYWTAKTQHTSLPLSKAPENEHFLGAASNPEEPWRNSLRCISEMNRL 242
Query: 241 FSGKGDITKPGYDPCNLLVDLDDIRDLSSGFSKYRDFIRYLPIHLSKYILRMLDRHTLNK 300
FSGK DITKPGYDPCNLLVDLDDIRDLSSGFSKYRDFIRYLPIHLSKYILRMLDRHTLNK
Sbjct: 243 FSGKADITKPGYDPCNLLVDLDDIRDLSSGFSKYRDFIRYLPIHLSKYILRMLDRHTLNK 302
Query: 301 CASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQGSYTRGIDPNYANKVSIPVPKMVDDGK 360
CASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQGSYTRGIDPNYANKVSIPVPKMVDDGK
Sbjct: 303 CASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQGSYTRGIDPNYANKVSIPVPKMVDDGK 362
Query: 361 SMRVKHPKWKLRTK 374
SMRVKHPKWKLRTK
Sbjct: 363 SMRVKHPKWKLRTK 376
>gi|169210888 PREDICTED: similar to FBXW10 protein [Homo sapiens]
Length = 243
Score = 474 bits (1219), Expect = e-133
Identities = 238/243 (97%), Positives = 239/243 (98%)
Query: 809 MSPDQFLLTVSALQHAHNSGEFAYPCRPQTEITDVWGPSISYPRKVLNFKGKSIQRAVDR 868
MSPDQFLLTVSALQHA NSGEFAYPCRPQTEITDVWGPSISYPRKVLNFKGKSIQRAVDR
Sbjct: 1 MSPDQFLLTVSALQHARNSGEFAYPCRPQTEITDVWGPSISYPRKVLNFKGKSIQRAVDR 60
Query: 869 LRLSNPPIDVKRTSIPLEIQKLQPNLKISLHSPRVQSTIPQPMIIRSRFSGSLKGGDQVT 928
LRLSNPPIDVKRTSIPLEIQKLQPNLKISLHSPR QSTIP+PMIIRSRFSGSLKGGDQVT
Sbjct: 61 LRLSNPPIDVKRTSIPLEIQKLQPNLKISLHSPRAQSTIPEPMIIRSRFSGSLKGGDQVT 120
Query: 929 SSIERAVCSTGPLTSMQVIKPNRMLAPQVGTATLSLKKERPRIYTALDPFRVNTEFVLLT 988
SSIERAVCSTGPLTSMQVIKPNRMLAPQVGTATLSLKKERPRIYTALDPFRVN EFVLLT
Sbjct: 121 SSIERAVCSTGPLTSMQVIKPNRMLAPQVGTATLSLKKERPRIYTALDPFRVNAEFVLLT 180
Query: 989 VKEEKEHQEAKMKEYQARESTGVVDPGKVSKAAWIRKIKGLPIDNFTKQGKTAAPELGQN 1048
VKEEKEHQEAKMKEYQARESTGVVDPGK SKAAWIRKIKGLPIDNFTKQGKTAAPELGQN
Sbjct: 181 VKEEKEHQEAKMKEYQARESTGVVDPGKASKAAWIRKIKGLPIDNFTKQGKTAAPELGQN 240
Query: 1049 VFI 1051
VFI
Sbjct: 241 VFI 243
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 125 bits (314), Expect = 2e-28
Identities = 95/410 (23%), Positives = 178/410 (43%), Gaps = 52/410 (12%)
Query: 275 RDFIRYLPIHLSKYILRMLDRHTLNKCASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQG 334
RDFI LP L+ Y+L L+ L + A ++W +A+ + + + +
Sbjct: 160 RDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAE-------------DNLLWREK 206
Query: 335 SYTRGID-PNYANKVSIPVPKMVDDGKSMRVKHPKWKLRTKNEYNLWTAYQNEETQQVLI 393
GID P + + + P + H WK ++ + T ++ E + +
Sbjct: 207 CKEEGIDEPLHIKRRKVIKPGFI---------HSPWKSAYIRQHRIDTNWRRGELKSPKV 257
Query: 394 ----EERNVFCGTYNVRILSDTWDQNRVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEF 449
++ + C + + G +++ S + + + + K +
Sbjct: 258 LKGHDDHVITC-----------------LQFCGNRIVSGSDDNTLKVWSAVTGKCLRT-L 299
Query: 450 RGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLV 509
GH G V + + +N ++SGS D +++ W+ ++G C GH T+ CM L + R+V
Sbjct: 300 VGHTGGVWSSQM--RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVV 357
Query: 510 SGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVK 568
SG RD ++VWD++TG+CL H + + + +VS +VKVW +
Sbjct: 358 SGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLH 417
Query: 569 TLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYERCLMAFK-HPKEVLDVSLLFLR 627
TL GH V L FD H++SGS D + W + + C+ H + L
Sbjct: 418 TLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDV--ETGNCIHTLTGHQSLTSGMELKDNI 475
Query: 628 VISACADGKIRIYNFLNGNCMKVLKANGRGDPVLSFFIQGNRMVVNTESN 677
++S AD ++I++ G C++ L+ + ++ +Q N+ V T S+
Sbjct: 476 LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVT-CLQFNKNFVITSSD 524
Score = 91.3 bits (225), Expect = 4e-18
Identities = 57/203 (28%), Positives = 100/203 (49%), Gaps = 17/203 (8%)
Query: 416 RVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDL 475
R + Y G +++ + + + + D + + +GH V +L + ++SGS D
Sbjct: 387 RCVQYDGRRVVSGAYDFMVKVWDP-ETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDT 443
Query: 476 SIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTF---- 531
SIR WD+++G C GHQ + M+L N LVSG D VK+WD+ TG+CL+T
Sbjct: 444 SIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 503
Query: 532 RHKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTL----SGHEGAVKCLFFDQWHL 587
+H+ + + N ++++S + G VK+W + + ++ L SG G V W +
Sbjct: 504 KHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGV------VWRI 557
Query: 588 LSGSTDGLVMAWSMVGKYERCLM 610
+ +T + S G E L+
Sbjct: 558 RASNTKLVCAVGSRNGTEETKLL 580
Score = 62.0 bits (149), Expect = 3e-09
Identities = 42/157 (26%), Positives = 74/157 (47%), Gaps = 23/157 (14%)
Query: 391 VLIEERNVFCGTYNVRILSDTWDQ-------------NRV--IHYSGGDLIAVSSNRKIH 435
V + R V G Y+ + WD NRV + + G +++ S + I
Sbjct: 389 VQYDGRRVVSGAYDFMV--KVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIR 446
Query: 436 LLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGG-- 493
+ D+ I GH + L ++N L+SG+ D +++ WD+K+G C + G
Sbjct: 447 VWDVETGNCIHT-LTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 503
Query: 494 -HQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLK 529
HQ +TC+ KN +++ D VK+WD+ TG+ ++
Sbjct: 504 KHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIR 540
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 125 bits (314), Expect = 2e-28
Identities = 95/410 (23%), Positives = 178/410 (43%), Gaps = 52/410 (12%)
Query: 275 RDFIRYLPIHLSKYILRMLDRHTLNKCASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQG 334
RDFI LP L+ Y+L L+ L + A ++W +A+ + + + +
Sbjct: 278 RDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAE-------------DNLLWREK 324
Query: 335 SYTRGID-PNYANKVSIPVPKMVDDGKSMRVKHPKWKLRTKNEYNLWTAYQNEETQQVLI 393
GID P + + + P + H WK ++ + T ++ E + +
Sbjct: 325 CKEEGIDEPLHIKRRKVIKPGFI---------HSPWKSAYIRQHRIDTNWRRGELKSPKV 375
Query: 394 ----EERNVFCGTYNVRILSDTWDQNRVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEF 449
++ + C + + G +++ S + + + + K +
Sbjct: 376 LKGHDDHVITC-----------------LQFCGNRIVSGSDDNTLKVWSAVTGKCLRT-L 417
Query: 450 RGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLV 509
GH G V + + +N ++SGS D +++ W+ ++G C GH T+ CM L + R+V
Sbjct: 418 VGHTGGVWSSQM--RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVV 475
Query: 510 SGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVK 568
SG RD ++VWD++TG+CL H + + + +VS +VKVW +
Sbjct: 476 SGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLH 535
Query: 569 TLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYERCLMAFK-HPKEVLDVSLLFLR 627
TL GH V L FD H++SGS D + W + + C+ H + L
Sbjct: 536 TLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDV--ETGNCIHTLTGHQSLTSGMELKDNI 593
Query: 628 VISACADGKIRIYNFLNGNCMKVLKANGRGDPVLSFFIQGNRMVVNTESN 677
++S AD ++I++ G C++ L+ + ++ +Q N+ V T S+
Sbjct: 594 LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVT-CLQFNKNFVITSSD 642
Score = 91.3 bits (225), Expect = 4e-18
Identities = 57/203 (28%), Positives = 100/203 (49%), Gaps = 17/203 (8%)
Query: 416 RVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDL 475
R + Y G +++ + + + + D + + +GH V +L + ++SGS D
Sbjct: 505 RCVQYDGRRVVSGAYDFMVKVWDP-ETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDT 561
Query: 476 SIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTF---- 531
SIR WD+++G C GHQ + M+L N LVSG D VK+WD+ TG+CL+T
Sbjct: 562 SIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 621
Query: 532 RHKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTL----SGHEGAVKCLFFDQWHL 587
+H+ + + N ++++S + G VK+W + + ++ L SG G V W +
Sbjct: 622 KHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGV------VWRI 675
Query: 588 LSGSTDGLVMAWSMVGKYERCLM 610
+ +T + S G E L+
Sbjct: 676 RASNTKLVCAVGSRNGTEETKLL 698
Score = 62.0 bits (149), Expect = 3e-09
Identities = 42/157 (26%), Positives = 74/157 (47%), Gaps = 23/157 (14%)
Query: 391 VLIEERNVFCGTYNVRILSDTWDQ-------------NRV--IHYSGGDLIAVSSNRKIH 435
V + R V G Y+ + WD NRV + + G +++ S + I
Sbjct: 507 VQYDGRRVVSGAYDFMV--KVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIR 564
Query: 436 LLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGG-- 493
+ D+ I GH + L ++N L+SG+ D +++ WD+K+G C + G
Sbjct: 565 VWDVETGNCIHT-LTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 621
Query: 494 -HQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLK 529
HQ +TC+ KN +++ D VK+WD+ TG+ ++
Sbjct: 622 KHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIR 658
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 125 bits (314), Expect = 2e-28
Identities = 95/410 (23%), Positives = 178/410 (43%), Gaps = 52/410 (12%)
Query: 275 RDFIRYLPIHLSKYILRMLDRHTLNKCASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQG 334
RDFI LP L+ Y+L L+ L + A ++W +A+ + + + +
Sbjct: 198 RDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAE-------------DNLLWREK 244
Query: 335 SYTRGID-PNYANKVSIPVPKMVDDGKSMRVKHPKWKLRTKNEYNLWTAYQNEETQQVLI 393
GID P + + + P + H WK ++ + T ++ E + +
Sbjct: 245 CKEEGIDEPLHIKRRKVIKPGFI---------HSPWKSAYIRQHRIDTNWRRGELKSPKV 295
Query: 394 ----EERNVFCGTYNVRILSDTWDQNRVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEF 449
++ + C + + G +++ S + + + + K +
Sbjct: 296 LKGHDDHVITC-----------------LQFCGNRIVSGSDDNTLKVWSAVTGKCLRT-L 337
Query: 450 RGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLV 509
GH G V + + +N ++SGS D +++ W+ ++G C GH T+ CM L + R+V
Sbjct: 338 VGHTGGVWSSQM--RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVV 395
Query: 510 SGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVK 568
SG RD ++VWD++TG+CL H + + + +VS +VKVW +
Sbjct: 396 SGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLH 455
Query: 569 TLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYERCLMAFK-HPKEVLDVSLLFLR 627
TL GH V L FD H++SGS D + W + + C+ H + L
Sbjct: 456 TLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDV--ETGNCIHTLTGHQSLTSGMELKDNI 513
Query: 628 VISACADGKIRIYNFLNGNCMKVLKANGRGDPVLSFFIQGNRMVVNTESN 677
++S AD ++I++ G C++ L+ + ++ +Q N+ V T S+
Sbjct: 514 LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVT-CLQFNKNFVITSSD 562
Score = 91.3 bits (225), Expect = 4e-18
Identities = 57/203 (28%), Positives = 100/203 (49%), Gaps = 17/203 (8%)
Query: 416 RVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDL 475
R + Y G +++ + + + + D + + +GH V +L + ++SGS D
Sbjct: 425 RCVQYDGRRVVSGAYDFMVKVWDP-ETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDT 481
Query: 476 SIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTF---- 531
SIR WD+++G C GHQ + M+L N LVSG D VK+WD+ TG+CL+T
Sbjct: 482 SIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 541
Query: 532 RHKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTL----SGHEGAVKCLFFDQWHL 587
+H+ + + N ++++S + G VK+W + + ++ L SG G V W +
Sbjct: 542 KHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGV------VWRI 595
Query: 588 LSGSTDGLVMAWSMVGKYERCLM 610
+ +T + S G E L+
Sbjct: 596 RASNTKLVCAVGSRNGTEETKLL 618
Score = 62.0 bits (149), Expect = 3e-09
Identities = 42/157 (26%), Positives = 74/157 (47%), Gaps = 23/157 (14%)
Query: 391 VLIEERNVFCGTYNVRILSDTWDQ-------------NRV--IHYSGGDLIAVSSNRKIH 435
V + R V G Y+ + WD NRV + + G +++ S + I
Sbjct: 427 VQYDGRRVVSGAYDFMV--KVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIR 484
Query: 436 LLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGG-- 493
+ D+ I GH + L ++N L+SG+ D +++ WD+K+G C + G
Sbjct: 485 VWDVETGNCIHT-LTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 541
Query: 494 -HQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLK 529
HQ +TC+ KN +++ D VK+WD+ TG+ ++
Sbjct: 542 KHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIR 578
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 99.0 bits (245), Expect = 2e-20
Identities = 58/196 (29%), Positives = 103/196 (52%), Gaps = 7/196 (3%)
Query: 464 EENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVD 523
++ ++SG D SI+ WD S C ++ GH G++ C+ + +V+G D V+VWDV+
Sbjct: 249 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVN 308
Query: 524 TGKCLKT-FRHKDPILATRINDTYIVSSCERGLVKVWHIAMA---QLVKTLSGHEGAVKC 579
TG+ L T H + +L R ++ +V+ + + VW +A A L + L GH AV
Sbjct: 309 TGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNV 368
Query: 580 LFFDQWHLLSGSTDGLVMAWS-MVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIR 638
+ FD +++S S D + WS ++ R L H + + + V+S +D IR
Sbjct: 369 VDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNG--HKRGIACLQYRDRLVVSGSSDNTIR 426
Query: 639 IYNFLNGNCMKVLKAN 654
+++ G C++VL+ +
Sbjct: 427 LWDIECGACLRVLEGH 442
Score = 95.1 bits (235), Expect = 3e-19
Identities = 64/261 (24%), Positives = 125/261 (47%), Gaps = 13/261 (4%)
Query: 389 QQVLIEERNVFCGTYNVRILSDTWDQNRVIH---YSGGDLIAVSSNRKIHLLDIIQVKAI 445
Q + E N CG +N++ + + ++ ++ Y +I+ + I + D ++ +
Sbjct: 214 QDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECL 273
Query: 446 PVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCK 505
V GH GSV L L +E +++GS D ++R WD+ +G H + +
Sbjct: 274 KV-LTGHTGSV--LCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSN 330
Query: 506 NRLVSGGRDCQVKVWDVDTGKCLKTFR----HKDPILATRINDTYIVSSCERGLVKVWHI 561
+V+ +D + VWD+ + + R H+ + +D YIVS+ +KVW
Sbjct: 331 GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWST 390
Query: 562 AMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYERCLMAFK-HPKEVLD 620
+ + V+TL+GH+ + CL + ++SGS+D + W + + CL + H + V
Sbjct: 391 STCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDI--ECGACLRVLEGHEELVRC 448
Query: 621 VSLLFLRVISACADGKIRIYN 641
+ R++S DGKI++++
Sbjct: 449 IRFDNKRIVSGAYDGKIKVWD 469
Score = 67.0 bits (162), Expect = 9e-11
Identities = 45/186 (24%), Positives = 78/186 (41%), Gaps = 33/186 (17%)
Query: 417 VIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLS 476
V+ + +++ S +R I + + + GH + L + ++SGS D +
Sbjct: 368 VVDFDDKYIVSASGDRTIKVWSTSTCEFVRT-LNGHKRGIACLQY--RDRLVVSGSSDNT 424
Query: 477 IRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDP 536
IR WD++ G C R+ GH+ + C+ R+VSG D ++KVWD+ DP
Sbjct: 425 IRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAA--------LDP 476
Query: 537 ILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLV 596
A ++TL H G V L FD++ ++S S D +
Sbjct: 477 RAP----------------------ASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTI 514
Query: 597 MAWSMV 602
+ W +
Sbjct: 515 LIWDFL 520
Score = 47.8 bits (112), Expect = 6e-05
Identities = 32/137 (23%), Positives = 59/137 (43%), Gaps = 12/137 (8%)
Query: 537 ILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLV 596
+ + +D I+S +K+W + +K L+GH G+V CL +D+ +++GS+D V
Sbjct: 243 VYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTV 302
Query: 597 MAWSMVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRIYNFLNGNCMKVLKANGR 656
W V E H + VL + +++ D I +++ +
Sbjct: 303 RVWD-VNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASAT---------- 351
Query: 657 GDPVLSFFIQGNRMVVN 673
D L + G+R VN
Sbjct: 352 -DITLRRVLVGHRAAVN 367
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 99.0 bits (245), Expect = 2e-20
Identities = 58/196 (29%), Positives = 103/196 (52%), Gaps = 7/196 (3%)
Query: 464 EENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVD 523
++ ++SG D SI+ WD S C ++ GH G++ C+ + +V+G D V+VWDV+
Sbjct: 215 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVN 274
Query: 524 TGKCLKT-FRHKDPILATRINDTYIVSSCERGLVKVWHIAMA---QLVKTLSGHEGAVKC 579
TG+ L T H + +L R ++ +V+ + + VW +A A L + L GH AV
Sbjct: 275 TGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNV 334
Query: 580 LFFDQWHLLSGSTDGLVMAWS-MVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIR 638
+ FD +++S S D + WS ++ R L H + + + V+S +D IR
Sbjct: 335 VDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNG--HKRGIACLQYRDRLVVSGSSDNTIR 392
Query: 639 IYNFLNGNCMKVLKAN 654
+++ G C++VL+ +
Sbjct: 393 LWDIECGACLRVLEGH 408
Score = 95.1 bits (235), Expect = 3e-19
Identities = 64/261 (24%), Positives = 125/261 (47%), Gaps = 13/261 (4%)
Query: 389 QQVLIEERNVFCGTYNVRILSDTWDQNRVIH---YSGGDLIAVSSNRKIHLLDIIQVKAI 445
Q + E N CG +N++ + + ++ ++ Y +I+ + I + D ++ +
Sbjct: 180 QDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECL 239
Query: 446 PVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCK 505
V GH GSV L L +E +++GS D ++R WD+ +G H + +
Sbjct: 240 KV-LTGHTGSV--LCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSN 296
Query: 506 NRLVSGGRDCQVKVWDVDTGKCLKTFR----HKDPILATRINDTYIVSSCERGLVKVWHI 561
+V+ +D + VWD+ + + R H+ + +D YIVS+ +KVW
Sbjct: 297 GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWST 356
Query: 562 AMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYERCLMAFK-HPKEVLD 620
+ + V+TL+GH+ + CL + ++SGS+D + W + + CL + H + V
Sbjct: 357 STCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDI--ECGACLRVLEGHEELVRC 414
Query: 621 VSLLFLRVISACADGKIRIYN 641
+ R++S DGKI++++
Sbjct: 415 IRFDNKRIVSGAYDGKIKVWD 435
Score = 67.0 bits (162), Expect = 9e-11
Identities = 45/186 (24%), Positives = 78/186 (41%), Gaps = 33/186 (17%)
Query: 417 VIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLS 476
V+ + +++ S +R I + + + GH + L + ++SGS D +
Sbjct: 334 VVDFDDKYIVSASGDRTIKVWSTSTCEFVRT-LNGHKRGIACLQY--RDRLVVSGSSDNT 390
Query: 477 IRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDP 536
IR WD++ G C R+ GH+ + C+ R+VSG D ++KVWD+ DP
Sbjct: 391 IRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAA--------LDP 442
Query: 537 ILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLV 596
A ++TL H G V L FD++ ++S S D +
Sbjct: 443 RAP----------------------ASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTI 480
Query: 597 MAWSMV 602
+ W +
Sbjct: 481 LIWDFL 486
Score = 47.8 bits (112), Expect = 6e-05
Identities = 32/137 (23%), Positives = 59/137 (43%), Gaps = 12/137 (8%)
Query: 537 ILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLV 596
+ + +D I+S +K+W + +K L+GH G+V CL +D+ +++GS+D V
Sbjct: 209 VYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTV 268
Query: 597 MAWSMVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRIYNFLNGNCMKVLKANGR 656
W V E H + VL + +++ D I +++ +
Sbjct: 269 RVWD-VNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASAT---------- 317
Query: 657 GDPVLSFFIQGNRMVVN 673
D L + G+R VN
Sbjct: 318 -DITLRRVLVGHRAAVN 333
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 99.0 bits (245), Expect = 2e-20
Identities = 58/196 (29%), Positives = 103/196 (52%), Gaps = 7/196 (3%)
Query: 464 EENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVD 523
++ ++SG D SI+ WD S C ++ GH G++ C+ + +V+G D V+VWDV+
Sbjct: 236 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVN 295
Query: 524 TGKCLKT-FRHKDPILATRINDTYIVSSCERGLVKVWHIAMA---QLVKTLSGHEGAVKC 579
TG+ L T H + +L R ++ +V+ + + VW +A A L + L GH AV
Sbjct: 296 TGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNV 355
Query: 580 LFFDQWHLLSGSTDGLVMAWS-MVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIR 638
+ FD +++S S D + WS ++ R L H + + + V+S +D IR
Sbjct: 356 VDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNG--HKRGIACLQYRDRLVVSGSSDNTIR 413
Query: 639 IYNFLNGNCMKVLKAN 654
+++ G C++VL+ +
Sbjct: 414 LWDIECGACLRVLEGH 429
Score = 95.1 bits (235), Expect = 3e-19
Identities = 64/261 (24%), Positives = 125/261 (47%), Gaps = 13/261 (4%)
Query: 389 QQVLIEERNVFCGTYNVRILSDTWDQNRVIH---YSGGDLIAVSSNRKIHLLDIIQVKAI 445
Q + E N CG +N++ + + ++ ++ Y +I+ + I + D ++ +
Sbjct: 201 QDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECL 260
Query: 446 PVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCK 505
V GH GSV L L +E +++GS D ++R WD+ +G H + +
Sbjct: 261 KV-LTGHTGSV--LCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSN 317
Query: 506 NRLVSGGRDCQVKVWDVDTGKCLKTFR----HKDPILATRINDTYIVSSCERGLVKVWHI 561
+V+ +D + VWD+ + + R H+ + +D YIVS+ +KVW
Sbjct: 318 GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWST 377
Query: 562 AMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYERCLMAFK-HPKEVLD 620
+ + V+TL+GH+ + CL + ++SGS+D + W + + CL + H + V
Sbjct: 378 STCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDI--ECGACLRVLEGHEELVRC 435
Query: 621 VSLLFLRVISACADGKIRIYN 641
+ R++S DGKI++++
Sbjct: 436 IRFDNKRIVSGAYDGKIKVWD 456
Score = 67.0 bits (162), Expect = 9e-11
Identities = 45/186 (24%), Positives = 78/186 (41%), Gaps = 33/186 (17%)
Query: 417 VIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLS 476
V+ + +++ S +R I + + + GH + L + ++SGS D +
Sbjct: 355 VVDFDDKYIVSASGDRTIKVWSTSTCEFVRT-LNGHKRGIACLQY--RDRLVVSGSSDNT 411
Query: 477 IRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDP 536
IR WD++ G C R+ GH+ + C+ R+VSG D ++KVWD+ DP
Sbjct: 412 IRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAA--------LDP 463
Query: 537 ILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLV 596
A ++TL H G V L FD++ ++S S D +
Sbjct: 464 RAP----------------------ASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTI 501
Query: 597 MAWSMV 602
+ W +
Sbjct: 502 LIWDFL 507
Score = 47.8 bits (112), Expect = 6e-05
Identities = 32/137 (23%), Positives = 59/137 (43%), Gaps = 12/137 (8%)
Query: 537 ILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLV 596
+ + +D I+S +K+W + +K L+GH G+V CL +D+ +++GS+D V
Sbjct: 230 VYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTV 289
Query: 597 MAWSMVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRIYNFLNGNCMKVLKANGR 656
W V E H + VL + +++ D I +++ +
Sbjct: 290 RVWD-VNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASAT---------- 338
Query: 657 GDPVLSFFIQGNRMVVN 673
D L + G+R VN
Sbjct: 339 -DITLRRVLVGHRAAVN 354
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 95.5 bits (236), Expect = 2e-19
Identities = 56/196 (28%), Positives = 102/196 (52%), Gaps = 7/196 (3%)
Query: 464 EENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVD 523
++ ++SG D +I+ WD + C RI GH G++ C+ + +++G D V+VWDV+
Sbjct: 276 DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVN 335
Query: 524 TGKCLKT-FRHKDPILATRINDTYIVSSCERGLVKVWHIAM---AQLVKTLSGHEGAVKC 579
TG+ L T H + +L R N+ +V+ + + VW +A L + L GH AV
Sbjct: 336 TGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNV 395
Query: 580 LFFDQWHLLSGSTDGLVMAW-SMVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIR 638
+ FD +++S S D + W + ++ R L H + + + V+S +D IR
Sbjct: 396 VDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNG--HKRGIACLQYRDRLVVSGSSDNTIR 453
Query: 639 IYNFLNGNCMKVLKAN 654
+++ G C++VL+ +
Sbjct: 454 LWDIECGACLRVLEGH 469
Score = 90.9 bits (224), Expect = 6e-18
Identities = 98/424 (23%), Positives = 168/424 (39%), Gaps = 71/424 (16%)
Query: 275 RDFIRYLPI----HLSKYILRMLDRHTLNKCASVSQHWAAMA-----------QQVKMDL 319
RDFI LP H+++ IL LD +L V + W + + V+ D
Sbjct: 142 RDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDS 201
Query: 320 SAHGFIQN----QITFLQGSYTRGIDPNYANKVSIPVPKMVDDGKSMRVKHPKWKLRTKN 375
G + Q F PN + P K++ D +++ W+
Sbjct: 202 LWRGLAERRGWGQYLFKNKPPDGNAPPNSFYRALYP--KIIQDIETIE---SNWRC---G 253
Query: 376 EYNLWTAYQNEETQQVLIEERNVFCGTYN----VRILSDT----WDQNRV---------- 417
++L + ET + V+C Y+ V L D WD+N +
Sbjct: 254 RHSLQRIHCRSETS------KGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHT 307
Query: 418 -----IHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGS 472
+ Y +I SS+ + + D+ + + H +V L L +++ S
Sbjct: 308 GSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIH-HCEAV--LHLRFNNGMMVTCS 364
Query: 473 YDLSIRYWDLKSGV---CTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLK 529
D SI WD+ S R+ GH+ + +D +VS D +KVW+ T + ++
Sbjct: 365 KDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVR 424
Query: 530 TFR-HKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLL 588
T HK I + D +VS +++W I ++ L GHE V+C+ FD ++
Sbjct: 425 TLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIV 484
Query: 589 SGSTDGLVMAWSMVGKYE-------RCLMAF-KHPKEVLDVSLLFLRVISACADGKIRIY 640
SG+ DG + W +V + CL +H V + +++S+ D I I+
Sbjct: 485 SGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIW 544
Query: 641 NFLN 644
+FLN
Sbjct: 545 DFLN 548
Score = 66.6 bits (161), Expect = 1e-10
Identities = 45/185 (24%), Positives = 88/185 (47%), Gaps = 10/185 (5%)
Query: 498 ITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRINDTYIVSSCERGLV 556
+ C+ ++VSG RD +K+WD +T +C + H +L + ++ I++ V
Sbjct: 270 VYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTV 329
Query: 557 KVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYE----RCLMAF 612
+VW + +++ TL H AV L F+ +++ S D + W M + R L+
Sbjct: 330 RVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGH 389
Query: 613 KHPKEVLDVSLLFLRVISACADGKIRIYNFLNGNCMKVLKANGRGDPVLSFFIQGNRMVV 672
+ V+D + ++SA D I+++N ++ L + RG L + +R+VV
Sbjct: 390 RAAVNVVDFDDKY--IVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQY---RDRLVV 444
Query: 673 NTESN 677
+ S+
Sbjct: 445 SGSSD 449
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 95.5 bits (236), Expect = 2e-19
Identities = 56/196 (28%), Positives = 102/196 (52%), Gaps = 7/196 (3%)
Query: 464 EENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVD 523
++ ++SG D +I+ WD + C RI GH G++ C+ + +++G D V+VWDV+
Sbjct: 312 DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVN 371
Query: 524 TGKCLKT-FRHKDPILATRINDTYIVSSCERGLVKVWHIAM---AQLVKTLSGHEGAVKC 579
TG+ L T H + +L R N+ +V+ + + VW +A L + L GH AV
Sbjct: 372 TGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNV 431
Query: 580 LFFDQWHLLSGSTDGLVMAW-SMVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIR 638
+ FD +++S S D + W + ++ R L H + + + V+S +D IR
Sbjct: 432 VDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNG--HKRGIACLQYRDRLVVSGSSDNTIR 489
Query: 639 IYNFLNGNCMKVLKAN 654
+++ G C++VL+ +
Sbjct: 490 LWDIECGACLRVLEGH 505
Score = 90.9 bits (224), Expect = 6e-18
Identities = 98/424 (23%), Positives = 168/424 (39%), Gaps = 71/424 (16%)
Query: 275 RDFIRYLPI----HLSKYILRMLDRHTLNKCASVSQHWAAMA-----------QQVKMDL 319
RDFI LP H+++ IL LD +L V + W + + V+ D
Sbjct: 178 RDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDS 237
Query: 320 SAHGFIQN----QITFLQGSYTRGIDPNYANKVSIPVPKMVDDGKSMRVKHPKWKLRTKN 375
G + Q F PN + P K++ D +++ W+
Sbjct: 238 LWRGLAERRGWGQYLFKNKPPDGNAPPNSFYRALYP--KIIQDIETIE---SNWRC---G 289
Query: 376 EYNLWTAYQNEETQQVLIEERNVFCGTYN----VRILSDT----WDQNRV---------- 417
++L + ET + V+C Y+ V L D WD+N +
Sbjct: 290 RHSLQRIHCRSETS------KGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHT 343
Query: 418 -----IHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGS 472
+ Y +I SS+ + + D+ + + H +V L L +++ S
Sbjct: 344 GSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIH-HCEAV--LHLRFNNGMMVTCS 400
Query: 473 YDLSIRYWDLKSGV---CTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLK 529
D SI WD+ S R+ GH+ + +D +VS D +KVW+ T + ++
Sbjct: 401 KDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVR 460
Query: 530 TFR-HKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLL 588
T HK I + D +VS +++W I ++ L GHE V+C+ FD ++
Sbjct: 461 TLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIV 520
Query: 589 SGSTDGLVMAWSMVGKYE-------RCLMAF-KHPKEVLDVSLLFLRVISACADGKIRIY 640
SG+ DG + W +V + CL +H V + +++S+ D I I+
Sbjct: 521 SGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIW 580
Query: 641 NFLN 644
+FLN
Sbjct: 581 DFLN 584
Score = 66.6 bits (161), Expect = 1e-10
Identities = 45/185 (24%), Positives = 88/185 (47%), Gaps = 10/185 (5%)
Query: 498 ITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRINDTYIVSSCERGLV 556
+ C+ ++VSG RD +K+WD +T +C + H +L + ++ I++ V
Sbjct: 306 VYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTV 365
Query: 557 KVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYE----RCLMAF 612
+VW + +++ TL H AV L F+ +++ S D + W M + R L+
Sbjct: 366 RVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGH 425
Query: 613 KHPKEVLDVSLLFLRVISACADGKIRIYNFLNGNCMKVLKANGRGDPVLSFFIQGNRMVV 672
+ V+D + ++SA D I+++N ++ L + RG L + +R+VV
Sbjct: 426 RAAVNVVDFDDKY--IVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQY---RDRLVV 480
Query: 673 NTESN 677
+ S+
Sbjct: 481 SGSSD 485
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 91.3 bits (225), Expect = 4e-18
Identities = 52/192 (27%), Positives = 99/192 (51%), Gaps = 14/192 (7%)
Query: 425 LIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKS 484
L++ S ++ + + D+ K + +GH+ V + N ++SGS+D S+R WD+K+
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKT-LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160
Query: 485 GVCTRIFGGHQGTITCMDLCK--NRLVSGGRDCQVKVWDVDTGKCLKTFRHKD--PILAT 540
G C + H ++ + + + +VS D ++WD +G+CLKT D P+
Sbjct: 161 GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV 220
Query: 541 RI--NDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFD------QWHLLSGST 592
+ N YI+++ +K+W + + +KT +GH+ C+F + +W ++SGS
Sbjct: 221 KFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKW-IVSGSE 279
Query: 593 DGLVMAWSMVGK 604
D LV W++ K
Sbjct: 280 DNLVYIWNLQTK 291
Score = 90.5 bits (223), Expect = 7e-18
Identities = 67/224 (29%), Positives = 103/224 (45%), Gaps = 14/224 (6%)
Query: 451 GHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDL--CKNRL 508
GH + + + N L+S S D +++ WD+ SG C + GH + C + N +
Sbjct: 85 GHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLI 144
Query: 509 VSGGRDCQVKVWDVDTGKCLKTF-RHKDPILATRIN--DTYIVSSCERGLVKVWHIAMAQ 565
VSG D V++WDV TGKCLKT H DP+ A N + IVSS GL ++W A Q
Sbjct: 145 VSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ 204
Query: 566 LVKTLSGHEG-AVKCLFF--DQWHLLSGSTDGLVMAWS-MVGKYERCLMAFKHPKEVLDV 621
+KTL + V + F + ++L+ + D + W GK + K+ K +
Sbjct: 205 CLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFA 264
Query: 622 SLLFLR---VISACADGKIRIYNFLNGNCMKVLKANGRGDPVLS 662
+ ++S D + I+N V K G D V+S
Sbjct: 265 NFSVTGGKWIVSGSEDNLVYIWNLQTKEI--VQKLQGHTDVVIS 306
Score = 81.6 bits (200), Expect = 3e-15
Identities = 63/251 (25%), Positives = 107/251 (42%), Gaps = 15/251 (5%)
Query: 444 AIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTIT--CM 501
A+ GH +V ++ +L S S D I+ W G + GH+ I+
Sbjct: 36 ALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAW 95
Query: 502 DLCKNRLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRIN--DTYIVSSCERGLVKV 558
N LVS D +K+WDV +GKCLKT + H + + N IVS V++
Sbjct: 96 SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRI 155
Query: 559 WHIAMAQLVKTLSGHEGAVKCLFF--DQWHLLSGSTDGLVMAWSMVGKYERCLMAF---- 612
W + + +KTL H V + F D ++S S DGL W +CL
Sbjct: 156 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS--GQCLKTLIDDD 213
Query: 613 KHPKEVLDVSLLFLRVISACADGKIRIYNFLNGNCMKVLKA--NGRGDPVLSFFIQGNRM 670
P + S +++A D ++++++ G C+K N + +F + G +
Sbjct: 214 NPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKW 273
Query: 671 VVNTESNVLMF 681
+V+ + L++
Sbjct: 274 IVSGSEDNLVY 284
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 91.3 bits (225), Expect = 4e-18
Identities = 52/192 (27%), Positives = 99/192 (51%), Gaps = 14/192 (7%)
Query: 425 LIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKS 484
L++ S ++ + + D+ K + +GH+ V + N ++SGS+D S+R WD+K+
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKT-LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160
Query: 485 GVCTRIFGGHQGTITCMDLCK--NRLVSGGRDCQVKVWDVDTGKCLKTFRHKD--PILAT 540
G C + H ++ + + + +VS D ++WD +G+CLKT D P+
Sbjct: 161 GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV 220
Query: 541 RI--NDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFD------QWHLLSGST 592
+ N YI+++ +K+W + + +KT +GH+ C+F + +W ++SGS
Sbjct: 221 KFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKW-IVSGSE 279
Query: 593 DGLVMAWSMVGK 604
D LV W++ K
Sbjct: 280 DNLVYIWNLQTK 291
Score = 90.5 bits (223), Expect = 7e-18
Identities = 67/224 (29%), Positives = 103/224 (45%), Gaps = 14/224 (6%)
Query: 451 GHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDL--CKNRL 508
GH + + + N L+S S D +++ WD+ SG C + GH + C + N +
Sbjct: 85 GHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLI 144
Query: 509 VSGGRDCQVKVWDVDTGKCLKTF-RHKDPILATRIN--DTYIVSSCERGLVKVWHIAMAQ 565
VSG D V++WDV TGKCLKT H DP+ A N + IVSS GL ++W A Q
Sbjct: 145 VSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ 204
Query: 566 LVKTLSGHEG-AVKCLFF--DQWHLLSGSTDGLVMAWS-MVGKYERCLMAFKHPKEVLDV 621
+KTL + V + F + ++L+ + D + W GK + K+ K +
Sbjct: 205 CLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFA 264
Query: 622 SLLFLR---VISACADGKIRIYNFLNGNCMKVLKANGRGDPVLS 662
+ ++S D + I+N V K G D V+S
Sbjct: 265 NFSVTGGKWIVSGSEDNLVYIWNLQTKEI--VQKLQGHTDVVIS 306
Score = 81.6 bits (200), Expect = 3e-15
Identities = 63/251 (25%), Positives = 107/251 (42%), Gaps = 15/251 (5%)
Query: 444 AIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTIT--CM 501
A+ GH +V ++ +L S S D I+ W G + GH+ I+
Sbjct: 36 ALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAW 95
Query: 502 DLCKNRLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRIN--DTYIVSSCERGLVKV 558
N LVS D +K+WDV +GKCLKT + H + + N IVS V++
Sbjct: 96 SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRI 155
Query: 559 WHIAMAQLVKTLSGHEGAVKCLFF--DQWHLLSGSTDGLVMAWSMVGKYERCLMAF---- 612
W + + +KTL H V + F D ++S S DGL W +CL
Sbjct: 156 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS--GQCLKTLIDDD 213
Query: 613 KHPKEVLDVSLLFLRVISACADGKIRIYNFLNGNCMKVLKA--NGRGDPVLSFFIQGNRM 670
P + S +++A D ++++++ G C+K N + +F + G +
Sbjct: 214 NPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKW 273
Query: 671 VVNTESNVLMF 681
+V+ + L++
Sbjct: 274 IVSGSEDNLVY 284
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 90.9 bits (224), Expect = 6e-18
Identities = 72/240 (30%), Positives = 109/240 (45%), Gaps = 42/240 (17%)
Query: 450 RGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKN--R 507
+GH SV+ + L S S D++I+ WD + C R GH ++ + + N
Sbjct: 147 KGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDH 206
Query: 508 LVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRIN-DTYIVSSCERG-LVKVWHIAMA 564
+VS RD +K+W+V TG C+KTF H++ + R N D +++SC V+VW +A
Sbjct: 207 IVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATK 266
Query: 565 QLVKTLSGHEGAVKCLFFDQW-------------------------HLLSGSTDGLVMAW 599
+ L HE V+C+ W LLSGS D + W
Sbjct: 267 ECKAELREHEHVVECI---SWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMW 323
Query: 600 SMVGKYERCLMAF-KHPKEVLDVSLLFL---RVISACADGK-IRIYNFLNGNCMKVLKAN 654
+ CLM H V V LF + I +CAD K +R++++ N CMK L A+
Sbjct: 324 DV--STGMCLMTLVGHDNWVRGV--LFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAH 379
Score = 63.2 bits (152), Expect = 1e-09
Identities = 49/206 (23%), Positives = 87/206 (42%), Gaps = 28/206 (13%)
Query: 421 SGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYW 480
+G +++ S ++ I + ++ Q F GH VR + ++ + S S D ++R W
Sbjct: 203 NGDHIVSASRDKTIKMWEV-QTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW 261
Query: 481 DLKSGVCTRIFGGHQGTITCMDLCKNR----------------------LVSGGRDCQVK 518
+ + C H+ + C+ L+SG RD +K
Sbjct: 262 VVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIK 321
Query: 519 VWDVDTGKCLKTFRHKDPILATRI---NDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEG 575
+WDV TG CL T D + + +I+S + ++VW + +KTL+ HE
Sbjct: 322 MWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEH 381
Query: 576 AVKCLFFDQW--HLLSGSTDGLVMAW 599
V L F + ++++GS D V W
Sbjct: 382 FVTSLDFHKTAPYVVTGSVDQTVKVW 407
Score = 59.3 bits (142), Expect = 2e-08
Identities = 54/251 (21%), Positives = 108/251 (43%), Gaps = 33/251 (13%)
Query: 420 YSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRY 479
+SG L + S++ I L D + I GH +V ++ + + ++S S D +I+
Sbjct: 160 HSGKLLASCSADMTIKLWDFQGFECIRT-MHGHDHNVSSVAIMPNGDHIVSASRDKTIKM 218
Query: 480 WDLKSGVCTRIFGGHQGTITCM--DLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDPI 537
W++++G C + F GH+ + + + + S D V+VW V T +C R + +
Sbjct: 219 WEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHV 278
Query: 538 LA----------TRINDT-------------YIVSSCERGLVKVWHIAMAQLVKTLSGHE 574
+ + I++ +++S +K+W ++ + TL GH+
Sbjct: 279 VECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHD 338
Query: 575 GAVKCLFFDQW--HLLSGSTDGLVMAWSMVGKYERC---LMAFKHPKEVLDVSLLFLRVI 629
V+ + F +LS + D + W K +RC L A +H LD V+
Sbjct: 339 NWVRGVLFHSGGKFILSCADDKTLRVWDY--KNKRCMKTLNAHEHFVTSLDFHKTAPYVV 396
Query: 630 SACADGKIRIY 640
+ D ++++
Sbjct: 397 TGSVDQTVKVW 407
Score = 46.2 bits (108), Expect = 2e-04
Identities = 29/102 (28%), Positives = 50/102 (49%), Gaps = 3/102 (2%)
Query: 422 GGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWD 481
G L++ S ++ I + D+ + + GH VR + F+LS + D ++R WD
Sbjct: 308 GPFLLSGSRDKTIKMWDVSTGMCL-MTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWD 366
Query: 482 LKSGVCTRIFGGHQGTITCMDLCKNR--LVSGGRDCQVKVWD 521
K+ C + H+ +T +D K +V+G D VKVW+
Sbjct: 367 YKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
Score = 43.5 bits (101), Expect = 0.001
Identities = 32/123 (26%), Positives = 54/123 (43%), Gaps = 7/123 (5%)
Query: 533 HKDPILATRINDTY--IVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWH--LL 588
H+ P+ + + +VS+ E +KVW +TL GH +V+ + FD L
Sbjct: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLA 166
Query: 589 SGSTDGLVMAWSMVGKYERCLMAFKHPKEVLDVSLL--FLRVISACADGKIRIYNFLNGN 646
S S D + W G +E H V V+++ ++SA D I+++ G
Sbjct: 167 SCSADMTIKLWDFQG-FECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGY 225
Query: 647 CMK 649
C+K
Sbjct: 226 CVK 228
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 90.9 bits (224), Expect = 6e-18
Identities = 56/214 (26%), Positives = 104/214 (48%), Gaps = 20/214 (9%)
Query: 403 YNVRILSDTWDQNRVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLC 462
+N+ I W + L++ S ++ + L D+ K + +GH+ V
Sbjct: 82 HNLEISDVAWSSD------SSRLVSASDDKTLKLWDVRSGKCLKT-LKGHSNYVFCCNFN 134
Query: 463 EEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDL-CKNRL-VSGGRDCQVKVW 520
N ++SGS+D +++ W++K+G C + H ++ + C L VSG D ++W
Sbjct: 135 PPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIW 194
Query: 521 DVDTGKCLKTFRHKD--PILATRI--NDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGA 576
D +G+CLKT D P+ + N YI+++ +K+W + + +KT +GH+
Sbjct: 195 DAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNE 254
Query: 577 VKCLFFD------QWHLLSGSTDGLVMAWSMVGK 604
C+F + +W ++SGS D LV W++ K
Sbjct: 255 KYCIFANFSVTGGKW-IVSGSEDNLVYIWNLQTK 287
Score = 85.5 bits (210), Expect = 2e-16
Identities = 66/226 (29%), Positives = 103/226 (45%), Gaps = 18/226 (7%)
Query: 451 GHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDL--CKNRL 508
GH + + + + L+S S D +++ WD++SG C + GH + C + N +
Sbjct: 81 GHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLI 140
Query: 509 VSGGRDCQVKVWDVDTGKCLKTF-RHKDPILATRIN--DTYIVSSCERGLVKVWHIAMAQ 565
+SG D VK+W+V TGKCLKT H DP+ A N + IVS GL ++W A Q
Sbjct: 141 ISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQ 200
Query: 566 LVKTLSGHEG-AVKCLFF--DQWHLLSGSTDGLVMAWSMVGKYERCLMAFK-HPKEVLDV 621
+KTL + V + F + ++L+ + D + W RCL + H E +
Sbjct: 201 CLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDY--SRGRCLKTYTGHKNEKYCI 258
Query: 622 SLLF-----LRVISACADGKIRIYNFLNGNCMKVLKANGRGDPVLS 662
F ++S D + I+N V K G D V+S
Sbjct: 259 FANFSVTGGKWIVSGSEDNLVYIWNLQTKEI--VQKLQGHTDVVIS 302
Score = 37.7 bits (86), Expect = 0.057
Identities = 41/179 (22%), Positives = 67/179 (37%), Gaps = 48/179 (26%)
Query: 487 CTRIFGGHQGTITCMDLCKNR--LVSGGRDCQVKVWDVDTGKCLKT-FRHKDPI--LATR 541
CT + GH ++ + N L S D + +W GK KT + H I +A
Sbjct: 35 CTLV--GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWS 92
Query: 542 INDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSM 601
+ + +VS+ + +K+W + + +KTL GH V C F+
Sbjct: 93 SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNP----------------- 135
Query: 602 VGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRIYNFLNGNCMKVLKANGRGDPV 660
P + +IS D ++I+ G C+K L A+ DPV
Sbjct: 136 -------------PSNL---------IISGSFDETVKIWEVKTGKCLKTLSAH--SDPV 170
>gi|157266266 WD repeat domain 86 [Homo sapiens]
Length = 376
Score = 86.3 bits (212), Expect = 1e-16
Identities = 46/155 (29%), Positives = 76/155 (49%), Gaps = 1/155 (0%)
Query: 450 RGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLV 509
RGH G+V L L + +GS D +IR WD+ SG R+F H+G++ C++L +
Sbjct: 190 RGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNRLVY 249
Query: 510 SGGRDCQVKVWDVDTGKCLKTF-RHKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVK 568
SG D VK W DTG+C++TF H+ + A + + + + + + +L +
Sbjct: 250 SGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAFDAQSGELRR 309
Query: 569 TLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSMVG 603
GH + C+ L + S DG + W + G
Sbjct: 310 VFRGHTFIINCIQVHGQVLYTASHDGALRLWDVRG 344
Score = 77.0 bits (188), Expect = 9e-14
Identities = 59/238 (24%), Positives = 97/238 (40%), Gaps = 21/238 (8%)
Query: 452 HAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSG 511
H G + L L + LL+GS D + R W G C + GH+ +T L +
Sbjct: 14 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTC 73
Query: 512 GRDCQVKVWDVDTGKCLKTFR-HKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTL 570
DC ++ WDV TG+CL+ +R H + + + + SS +VW + Q+ +
Sbjct: 74 SADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKGQMSREF 133
Query: 571 SGHEGAVKCLFFD-QWH---------------LLSGSTDGLVMAWSMV-GKYERCLMAFK 613
GH V L + W L++GSTDG W + G + L
Sbjct: 134 RGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHT 193
Query: 614 HPKEVLDVSLLFLRVISACADGKIRIYNFLNGNCMKVLKANGRGDPVLSFFIQGNRMV 671
L + + D IR ++ L+G ++V + + RG + + NR+V
Sbjct: 194 GAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREH-RGSVICLELV--NRLV 248
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 81.3 bits (199), Expect = 5e-15
Identities = 94/446 (21%), Positives = 179/446 (40%), Gaps = 59/446 (13%)
Query: 417 VIHYSGGDLIAVSSNR-KIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDL 475
V+ + G L+A + +++L I + I + GH V ++ L E +++GS
Sbjct: 27 VLGKASGRLLATGGDDCRVNLWSINKPNCI-MSLTGHTSPVESVRLNTPEELIVAGSQSG 85
Query: 476 SIRYWDLKSGVCTRIFGGHQGTITCMDL--CKNRLVSGGRDCQVKVWDVDTGKCLKTFR- 532
SIR WDL++ R GH+ I +D + SG +D +K+WD+ C+ +R
Sbjct: 86 SIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRG 145
Query: 533 HKDPILATRI--NDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFF--DQWHLL 588
H + R + ++ S+ + VK+W + +++ GH G V + F +++ L
Sbjct: 146 HSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLA 205
Query: 589 SGSTDGLVMAWSMVGKYERCLMAFKHPKEVLDVSLLF----LRVISACADGKIRIYNFLN 644
SGS+D + W + K++ P V S+LF + S C D +R+Y +
Sbjct: 206 SGSSDRTIRFWDL-EKFQVVSCIEGEPGPVR--SVLFNPDGCCLYSGCQD-SLRVYGWEP 261
Query: 645 GNCMKVLKANGRGDPVLSFFIQGNRMVVNTESNVLMFQFEHIKWQYAVEKTKQKKNKEKE 704
C V+ N L+ V ++SNV Y V+ T+ +
Sbjct: 262 ERCFDVVLVNWGKVADLAICNDQLIGVAFSQSNVS---------SYVVDLTRVTRT---- 308
Query: 705 EEKEENSLMEILSKCNIQVHSPRESVSSKQTVIQELLPGKPPKSRVLLKPAKFSSAVLIE 764
+++ +Q H P + Q L P R+ +P+ S
Sbjct: 309 ---------GTVARDPVQDHRP---------LAQPLPNPSAPLRRIYERPSTTCSKPQRV 350
Query: 765 ELQSQGKSKSPRRDDDVEKAQKQGQLET----------PGKLPSHPKKKSWKIPMSPDQF 814
+ S+ + +SP +DD ++ + + +++ + P ++S P P+
Sbjct: 351 KQNSESERRSPSSEDDRDERESRAEIQNAEDYNEIFQPKNSISRTPPRRSEPFPAPPEDD 410
Query: 815 LLTVSALQHAHNSGEFAYPCRPQTEI 840
T + + +P P E+
Sbjct: 411 AATAKEAAKPSPAMDVQFPV-PNLEV 435
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 81.3 bits (199), Expect = 5e-15
Identities = 80/319 (25%), Positives = 137/319 (42%), Gaps = 36/319 (11%)
Query: 334 GSYTRGIDPNYANKVSIPVPKMVDDGKS---MRVKHPKWKLRTKNE-------YNLWTAY 383
GS ++ DPN + IP+P++ D K M +K ++R + Y AY
Sbjct: 411 GSKSKKQDPNAPPQNRIPLPELKDSDKLDKIMNMKETTKRVRLGPDCLPSICFYTFLNAY 470
Query: 384 QNEETQQVLIEERNVFCGTY---NVRILSDTWDQNRVIHYSGGDLIAVSSNRKIHLLDII 440
Q V ++ ++ G + VR+ S T + R + + +++ +L+ I
Sbjct: 471 QGLTAVDVT-DDSSLIAGGFADSTVRVWSVTPKKLRSVKQASD--LSLIDKESDDVLERI 527
Query: 441 QVKAIPVEFR---GHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGT 497
+ E + GH+G V + N+LLS S D ++R W L++ C + GH
Sbjct: 528 MDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYP 587
Query: 498 I--TCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCE 552
+ T VSGG D ++W D + L+ F H + TR N Y+ +
Sbjct: 588 VWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSA 647
Query: 553 RGLVKVWHIAMAQLVKTLSGHEGAVKCLFF--DQWHLLSGSTDGLVMAWS-----MVGKY 605
V++W + V+ +GH+G + L F + L +G+TDG V+ W MVG+
Sbjct: 648 DRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGEL 707
Query: 606 ER-----CLMAFKHPKEVL 619
+ C + F E+L
Sbjct: 708 KGHTDTVCSLRFSRDGEIL 726
Score = 60.1 bits (144), Expect = 1e-08
Identities = 34/116 (29%), Positives = 55/116 (47%), Gaps = 5/116 (4%)
Query: 449 FRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNR- 507
F GH V N++ +GS D ++R WD+ +G C RIF GH+G I + N
Sbjct: 623 FAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGR 682
Query: 508 -LVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCERGLVKVW 559
L +G D +V +WD+ G + + H D + + R + + S V++W
Sbjct: 683 FLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
Score = 49.3 bits (116), Expect = 2e-05
Identities = 49/220 (22%), Positives = 83/220 (37%), Gaps = 45/220 (20%)
Query: 472 SYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLC--KNRLVSGGRDCQVKVWDVDTGKCLK 529
S D+ R D K+ +I GH G + +N L+S D V++W + T CL
Sbjct: 520 SDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLV 579
Query: 530 TFR-HKDPILATRINDT--YIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWH 586
++ H P+ T+ + Y VS + ++W Q ++ +GH V C F
Sbjct: 580 GYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRF---- 635
Query: 587 LLSGSTDGLVMAWSMVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRIYNFLNGN 646
HP V + AD +R+++ LNGN
Sbjct: 636 ---------------------------HPNSNY--------VATGSADRTVRLWDVLNGN 660
Query: 647 CMKVLKANGRGDPVLSFFIQGNRMVVN-TESNVLMFQFEH 685
C+++ + L+F G + T+ VL++ H
Sbjct: 661 CVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGH 700
Score = 30.4 bits (67), Expect = 9.1
Identities = 13/34 (38%), Positives = 19/34 (55%)
Query: 448 EFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWD 481
E +GH +V +L + L SGS D ++R WD
Sbjct: 706 ELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
>gi|19913369 transducin beta-like 3 [Homo sapiens]
Length = 808
Score = 78.6 bits (192), Expect = 3e-14
Identities = 76/313 (24%), Positives = 142/313 (45%), Gaps = 38/313 (12%)
Query: 426 IAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDL-KS 484
+ V+SN + +Q A + GH V AL + + S + D S+R W + K+
Sbjct: 350 VVVASNSPCLKVFELQTSACQI-LHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKA 408
Query: 485 G--VCTRIFGGHQ---GTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLK-TFRHKDPIL 538
G +C GH GT+ C L ++ LV+G +DC VK+W + K T PIL
Sbjct: 409 GQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPIL 468
Query: 539 -----------------ATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLF 581
A ND + + + K+W + QL+ SGH + C+
Sbjct: 469 LQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQ 528
Query: 582 FDQWH--LLSGSTDGLVMAWSMVGKYERCLMAFK-HPKEVLDVSLLF--LRVISACADGK 636
F L + S DG + W++ + CL F+ H VL V+ + +++S+ +DG
Sbjct: 529 FSPMDQVLATASADGTIKLWAL--QDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGL 586
Query: 637 IRIYNFLNGNCMKVLKANGRGDPVLSFF---IQGNRMVVNTESNVLMFQFEHIKWQYAVE 693
++++ N C++ L A+ D V + + + ++S V++++ + + + A E
Sbjct: 587 VKLWTIKNNECVRTLDAH--EDKVWGLHCSRLDDHALTGASDSRVILWK-DVTEAEQAEE 643
Query: 694 KTKQKKNKEKEEE 706
+ +Q++ +++E
Sbjct: 644 QARQEEQVVRQQE 656
Score = 51.6 bits (122), Expect = 4e-06
Identities = 65/300 (21%), Positives = 116/300 (38%), Gaps = 38/300 (12%)
Query: 421 SGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYW 480
+G L V R +++L++ + + + A L + L++ S L + W
Sbjct: 35 TGQHLFCVCGTR-VNILEVASGAVLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQW 93
Query: 481 DLKSGVCTRIFGG-HQGTITCM--DLCKNRLVSGGRDCQVKVWDVDTGKCLKTFR----- 532
+ G TR++ H + M D L +GG D V+VWD+ FR
Sbjct: 94 AWQEGSVTRLWKAIHTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGV 153
Query: 533 ------HKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFF--DQ 584
H DP TR+ + SS ++VW + + L+ H AV L F D
Sbjct: 154 VHLVAFHPDP---TRL---LLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADG 207
Query: 585 WHLLSGSTDGLVMAWSMVG-----------KYERCLMAFKHPKEVLDVSLLFLRVISACA 633
+LS D + + W + E ++ + P L V L ++A
Sbjct: 208 HTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGD 267
Query: 634 DGKIRIYNFLNGNCMKV-LKANGRGDPVLSFFIQGNRMVVNT---ESNVLMFQFEHIKWQ 689
G +R++ +G C+ + G G + + VV T + N+L+++ ++ Q
Sbjct: 268 QGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLLYEARSLRLQ 327
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 76.6 bits (187), Expect = 1e-13
Identities = 59/214 (27%), Positives = 91/214 (42%), Gaps = 20/214 (9%)
Query: 400 CG-TYNVRILSDTWDQNRVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRA 458
CG Y+ R L+D+ L++ S + I D+ V ++GHA V
Sbjct: 342 CGPVYSTRFLADS-----------SGLLSCSEDMSIRYWDLGSFTNT-VLYQGHAYPVWD 389
Query: 459 LFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDL--CKNRLVSGGRDCQ 516
L + + SGS+D + R W RI+ GH + C+ N L +G D
Sbjct: 390 LDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKT 449
Query: 517 VKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCERGLVKVWHIAMAQLVKTLSGH 573
V++W G ++ F H+ P+L+ N Y+ S+ E +K+W +A L K L GH
Sbjct: 450 VRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGH 509
Query: 574 EGAVKCLFF--DQWHLLSGSTDGLVMAWSMVGKY 605
+ L F D + S S D V W + Y
Sbjct: 510 TDNITSLTFSPDSGLIASASMDNSVRVWDIRNTY 543
Score = 36.6 bits (83), Expect = 0.13
Identities = 17/68 (25%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 421 SGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYW 480
+G L + ++++ L D+ + E RGH ++ +L + + S S D S+R W
Sbjct: 479 NGKYLASAGEDQRLKLWDLAS-GTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVW 537
Query: 481 DLKSGVCT 488
D+++ C+
Sbjct: 538 DIRNTYCS 545
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 76.3 bits (186), Expect = 1e-13
Identities = 65/267 (24%), Positives = 118/267 (44%), Gaps = 16/267 (5%)
Query: 423 GDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDL 482
GD IA S K L ++ FRGH + L + + +GS D + + WD+
Sbjct: 147 GDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDI 206
Query: 483 KSGVCTRIFGGHQGTITCM--DLCKNRLVSGGRDCQVKVWDVDTGKCLK-TFRHKDPILA 539
++G GH I + + +R+++G D V VWD DTG+ + H I +
Sbjct: 207 QNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISS 266
Query: 540 TRIN--DTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAV--KCLFFDQWHLLSGSTDGL 595
N + I++ K+W + V TL+GH+ + C + + + S DG
Sbjct: 267 ASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGT 326
Query: 596 VMAWSMVGKYERCLMAFK-HPKEVLDVSL--LFLRVISACADGKIRIYNFLNGNCMKVLK 652
+S + +C+ + H E+ +S +++ +D RI++ G C++VL+
Sbjct: 327 ARIFSAATR--KCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLE 384
Query: 653 ANGRGDPVLS--FFIQGNRMVVNTESN 677
G D + S F +GN ++ ++ N
Sbjct: 385 --GHTDEIFSCAFNYKGNIVITGSKDN 409
Score = 73.9 bits (180), Expect = 7e-13
Identities = 59/244 (24%), Positives = 106/244 (43%), Gaps = 24/244 (9%)
Query: 429 SSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCT 488
+SN +L +++ +P+ + L + + ++GSYD + + WD SG
Sbjct: 77 NSNHTFYLFKVLKAHILPLT---------NVALNKSGSCFITGSYDRTCKLWDTASGEEL 127
Query: 489 RIFGGHQGTITCMDLCK---NRLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRIN- 543
GH+ + + +++ +G D K+W V+TGKC TFR H I+ N
Sbjct: 128 NTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNP 187
Query: 544 -DTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQW--HLLSGSTDGLVMAWS 600
T + + K+W I + V TL GH + L F+ +++GS D V+ W
Sbjct: 188 QSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD 247
Query: 601 M-VGKYERCLMAFKHPKEVLDVSLLF--LRVISACADGKIRIYNFLNGNCMKVLKANGRG 657
G+ L+ H E+ S + +++ D ++++ NG C+ L G
Sbjct: 248 ADTGRKVNILIG--HCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATL--TGHD 303
Query: 658 DPVL 661
D +L
Sbjct: 304 DEIL 307
Score = 48.1 bits (113), Expect = 4e-05
Identities = 28/103 (27%), Positives = 50/103 (48%), Gaps = 3/103 (2%)
Query: 420 YSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRY 479
Y+G + S++ + K I + GH G + + + N LL+GS D + R
Sbjct: 313 YTGKLIATASADGTARIFSAATRKCI-AKLEGHEGEISKISFNPQGNHLLTGSSDKTARI 371
Query: 480 WDLKSGVCTRIFGGHQGTI-TCMDLCK-NRLVSGGRDCQVKVW 520
WD ++G C ++ GH I +C K N +++G +D ++W
Sbjct: 372 WDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 75.1 bits (183), Expect = 3e-13
Identities = 62/245 (25%), Positives = 108/245 (44%), Gaps = 13/245 (5%)
Query: 382 AYQNEETQQVLIEERNVFCGTYNVRILSDTWDQNRV----IHYSGGDLIAVSSNRKIHLL 437
A Q + T L++ C + I+ + + V H +G L + +R I L
Sbjct: 34 AGQQQATPGALLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLW 93
Query: 438 DIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGT 497
++ +GH+G+V L + + L S S D ++ WD ++G + GH
Sbjct: 94 NVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSF 153
Query: 498 I-TCMDLCK--NRLVSGGRDCQVKVWDVDTGKCLKTFRHKDPILATRINDT--YIVSSCE 552
+ +C + + +G D VK+WD+ ++TF++ +LA NDT I+S
Sbjct: 154 VNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGI 213
Query: 553 RGLVKVWHIAMAQLVKTLSGHEGAVK--CLFFDQWHLLSGSTDGLVMAWSM--VGKYERC 608
+KVW + +L T+ GH +V L + +LLS + D V W + ERC
Sbjct: 214 DNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERC 273
Query: 609 LMAFK 613
+ F+
Sbjct: 274 VKIFQ 278
Score = 49.7 bits (117), Expect = 1e-05
Identities = 48/187 (25%), Positives = 84/187 (44%), Gaps = 16/187 (8%)
Query: 422 GGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWD 481
G L+ S+ L I+ KA F+ + V A+ + + ++SG D I+ WD
Sbjct: 163 GPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWD 221
Query: 482 LKSGVCTRIFGGHQGTITCMDLCK--NRLVSGGRDCQVKVWDV----DTGKCLKTFR--- 532
L+ T GH ++T + L + L+S D V+VWDV +C+K F+
Sbjct: 222 LRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNV 281
Query: 533 ---HKDPILATRIND-TYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFF--DQWH 586
K+ + + D + I + V VW +++ L GH G++ + F D+
Sbjct: 282 HNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPI 341
Query: 587 LLSGSTD 593
++S S+D
Sbjct: 342 IISASSD 348
Score = 46.2 bits (108), Expect = 2e-04
Identities = 46/158 (29%), Positives = 73/158 (46%), Gaps = 27/158 (17%)
Query: 399 FCGTYNVRILS--DTWDQNRVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSV 456
F TY V ++ DT DQ +I+ + I + D+ Q K + RGHA SV
Sbjct: 190 FQNTYQVLAVTFNDTSDQ----------IISGGIDNDIKVWDLRQNK-LTYTMRGHADSV 238
Query: 457 RALFLCEEENFLLSGSYDLSIRYWDLKSGV----CTRIFGGH-----QGTITC-MDLCKN 506
L L E ++LLS + D ++R WD++ C +IF G+ + + C +
Sbjct: 239 TGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGS 298
Query: 507 RLVSGGRDCQVKVWDVDTGKCLKTFRHKDPILATRIND 544
++ +G D V VWD + + L +K P A IN+
Sbjct: 299 KIAAGSADRFVYVWDTTSRRIL----YKLPGHAGSINE 332
>gi|18874090 WD repeat domain 48 [Homo sapiens]
Length = 677
Score = 73.9 bits (180), Expect = 7e-13
Identities = 58/205 (28%), Positives = 88/205 (42%), Gaps = 21/205 (10%)
Query: 452 HAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNR--LV 509
H V + LC L+S S D +++ W+ G C H+ + + K++ +
Sbjct: 74 HTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVA 133
Query: 510 SGGRDCQVKVWDVDTGKCLKTFR----------HKDPILATRIND--TYIVSSCERGLVK 557
S G D Q+ +WDV+T L +KD I + +N T IVS +++
Sbjct: 134 SAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLR 193
Query: 558 VWHIAMAQLVKTLSGHEGAVKCLFF--DQWHLLSGSTDGLVMAWSMVGKYERCLMAFKHP 615
VW + L GH VK L D LSGS+DG + WS+ +RC+ ++
Sbjct: 194 VWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSL--GQQRCIATYRVH 251
Query: 616 KE---VLDVSLLFLRVISACADGKI 637
E L V+ F V S D KI
Sbjct: 252 DEGVWALQVNDAFTHVYSGGRDRKI 276
Score = 40.4 bits (93), Expect = 0.009
Identities = 28/102 (27%), Positives = 47/102 (46%), Gaps = 2/102 (1%)
Query: 423 GDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDL 482
G +I S K+ + + A ++ +GH +V+AL L + LSGS D +IR W L
Sbjct: 180 GTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSL 239
Query: 483 KSGVCTRIFGGHQGTITCMDL--CKNRLVSGGRDCQVKVWDV 522
C + H + + + + SGGRD ++ D+
Sbjct: 240 GQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDL 281
Score = 39.7 bits (91), Expect = 0.015
Identities = 30/116 (25%), Positives = 51/116 (43%), Gaps = 22/116 (18%)
Query: 501 MDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDPILATR------INDTY-------I 547
+D NRL + GRD +++W V+ K +DP +A+ +ND +
Sbjct: 38 LDPALNRLFTAGRDSIIRIWSVNQHK-------QDPYIASMEHHTDWVNDIVLCCNGKTL 90
Query: 548 VSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFF--DQWHLLSGSTDGLVMAWSM 601
+S+ VKVW+ + TL H+ VK L + D+ + S D + W +
Sbjct: 91 ISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDV 146
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 73.6 bits (179), Expect = 9e-13
Identities = 52/163 (31%), Positives = 79/163 (48%), Gaps = 12/163 (7%)
Query: 450 RGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKN--R 507
RGH+ V + + + F LSGS+D ++R WDL +G TR F GH + + + +
Sbjct: 60 RGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQ 119
Query: 508 LVSGGRDCQVKVWDVDTGKCLKTFR---HKDPILATRI----NDTYIVSSCERGLVKVWH 560
+VSG RD +K+W+ G C T + H + + R ++ IVS LVKVW+
Sbjct: 120 IVSGSRDKTIKLWNT-LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWN 178
Query: 561 IAMAQLVKTLSGHEGAVKCLFF--DQWHLLSGSTDGLVMAWSM 601
+A +L GH G + + D SG DG M W +
Sbjct: 179 LANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL 221
Score = 44.3 bits (103), Expect = 6e-04
Identities = 50/218 (22%), Positives = 90/218 (41%), Gaps = 17/218 (7%)
Query: 401 GTYNVRILSDTWDQNRVIHYSGG-DLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRAL 459
GT R + T D V S +++ S ++ I L + + V V+ H+ V +
Sbjct: 95 GTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCV 154
Query: 460 FLCEEEN--FLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLV--SGGRDC 515
+ ++S +D ++ W+L + GH G + + + + + SGG+D
Sbjct: 155 RFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDG 214
Query: 516 QVKVWDVDTGKCLKTFRHKDPILATRIN-DTYIVSSCERGLVKVWHI-------AMAQLV 567
Q +WD++ GK L T D I A + + Y + + +K+W + + Q V
Sbjct: 215 QAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEV 274
Query: 568 KTLSGHEGAVKCLFF----DQWHLLSGSTDGLVMAWSM 601
+ S +C D L +G TD LV W +
Sbjct: 275 ISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312
Score = 30.8 bits (68), Expect = 7.0
Identities = 24/124 (19%), Positives = 49/124 (39%), Gaps = 13/124 (10%)
Query: 493 GHQGTITCMDLCK---NRLVSGGRDCQVKVWDVDTG--------KCLKTFRHKDPILATR 541
GH G +T + + ++S RD + +W + + L+ H +
Sbjct: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVIS 72
Query: 542 INDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFF--DQWHLLSGSTDGLVMAW 599
+ + +S G +++W + + GH V + F D ++SGS D + W
Sbjct: 73 SDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLW 132
Query: 600 SMVG 603
+ +G
Sbjct: 133 NTLG 136
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 72.4 bits (176), Expect = 2e-12
Identities = 57/214 (26%), Positives = 96/214 (44%), Gaps = 14/214 (6%)
Query: 451 GHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLC--KNRL 508
GH G V+ + + S S D ++R WD+ C R+ GHQ ++ + +L
Sbjct: 61 GHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQL 120
Query: 509 VSGGRDCQVKVWDVDTGKCLKTF-RHKDPILATRINDTY--IVSSCERGLVKVWHIAM-- 563
SGG D +V +WDV +G+ L+ H+D I ++ + T + + V +W + M
Sbjct: 121 ASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVT 180
Query: 564 -AQLVKTLSGHEGAVKCLFFDQWHLL-SGSTDGLVMAWSMVGKYERCLMAFK-HPKEVLD 620
A + L GH + CL + LL SGS D + W L+ K H V
Sbjct: 181 PAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPT--TSSLLIQLKGHVTWVKS 238
Query: 621 VSLL--FLRVISACADGKIRIYNFLNGNCMKVLK 652
++ L + SA +++++ G C++ LK
Sbjct: 239 IAFSPDELWLASAGYSRMVKVWDCNTGKCLETLK 272
Score = 59.3 bits (142), Expect = 2e-08
Identities = 42/163 (25%), Positives = 71/163 (43%), Gaps = 13/163 (7%)
Query: 449 FRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCK--- 505
F H G V + + LL+GS D + W+ +SG GGH G + C+
Sbjct: 17 FGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPV---KFCRFSP 73
Query: 506 --NRLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPI--LATRINDTYIVSSCERGLVKVWH 560
+ S DC V++WDV KCL+ + H+ + ++ + + S V +W
Sbjct: 74 DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133
Query: 561 IAMAQLVKTLSGHEGAVKCLFFDQW--HLLSGSTDGLVMAWSM 601
+ Q+++ L GH +++ F L +GS D V W +
Sbjct: 134 VQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDL 176
Score = 58.5 bits (140), Expect = 3e-08
Identities = 56/223 (25%), Positives = 92/223 (41%), Gaps = 21/223 (9%)
Query: 427 AVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGV 486
+ S + + L D+ + K + V +GH SV + + L SG +D + WD++SG
Sbjct: 80 SASCDCTVRLWDVARAKCLRV-LKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQ 138
Query: 487 CTRIFGGHQGTITCMDLCK--NRLVSGGRDCQVKVWDVD------TGKCLKTFRHKDPIL 538
R+ GH+ +I D N L +G D V +WD+ + + L+ L
Sbjct: 139 MLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCL 198
Query: 539 ATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFF--DQWHLLSGSTDGLV 596
+ S ++ + +W + L+ L GH VK + F D+ L S +V
Sbjct: 199 CYSASGLLASGSWDK-TIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMV 257
Query: 597 MAWSMVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRI 639
W +CL K VLDV+ + DGKI +
Sbjct: 258 KVWDC--NTGKCLETL---KGVLDVA----HTCAFTPDGKILV 291
Score = 33.9 bits (76), Expect = 0.83
Identities = 30/100 (30%), Positives = 42/100 (42%), Gaps = 3/100 (3%)
Query: 567 VKTLSGHEGAVKCLFF--DQWHLLSGSTDGLVMAW-SMVGKYERCLMAFKHPKEVLDVSL 623
VK H G V F D LL+GS DG V W + G+ L P + S
Sbjct: 14 VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSP 73
Query: 624 LFLRVISACADGKIRIYNFLNGNCMKVLKANGRGDPVLSF 663
SA D +R+++ C++VLK + R +SF
Sbjct: 74 DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSF 113
>gi|4759276 RNA, U3 small nucleolar interacting protein 2 [Homo
sapiens]
Length = 475
Score = 70.9 bits (172), Expect = 6e-12
Identities = 65/249 (26%), Positives = 114/249 (45%), Gaps = 25/249 (10%)
Query: 450 RGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFG-----------GHQGTI 498
RGH S+ L + +++ + S + D SI W ++SG + GH +
Sbjct: 143 RGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHV 202
Query: 499 TCMDLCKNR--LVSGGRDCQVKVWDVDTGKCLKTFR-HKDPI--LATRINDTYIVSSCER 553
CM + + L SG R + +W+ + + L TF H+D + LA R + S+
Sbjct: 203 LCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHD 262
Query: 554 GLVKVWHIAMAQLVKTLSGHEGAVKCL--FFDQWHLLSGSTDGLVMAWSMVGKYERCLMA 611
VKVW++A V+TL GH+ AV L + + +G DG V W + E L+
Sbjct: 263 RSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKI--PEESQLVF 320
Query: 612 FKHPKEVLDVSLL-FLRVISACADGKIRIYNFLNGNCMKVLK-ANG-RGDPVLS--FFIQ 666
+ H + + L+ ++S DG + ++ + + + A+G RG+P L F+I
Sbjct: 321 YGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWIS 380
Query: 667 GNRMVVNTE 675
++NT+
Sbjct: 381 SVAALLNTD 389
Score = 55.8 bits (133), Expect = 2e-07
Identities = 38/145 (26%), Positives = 63/145 (43%), Gaps = 3/145 (2%)
Query: 421 SGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYW 480
S G +A K+ L+ Q F GH +V L + L S S+D S++ W
Sbjct: 209 SDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVW 268
Query: 481 DLKSGVCTRIFGGHQGTITCMDLCKNR--LVSGGRDCQVKVWDVDTGKCLKTFRHKDPIL 538
++ GHQ + +D + +GGRD V+VW + L + H+ I
Sbjct: 269 NVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYGHQGSID 328
Query: 539 ATR-INDTYIVSSCERGLVKVWHIA 562
IN+ ++VS + G V +W ++
Sbjct: 329 CIHLINEEHMVSGADDGSVALWGLS 353
Score = 53.1 bits (126), Expect = 1e-06
Identities = 44/171 (25%), Positives = 70/171 (40%), Gaps = 19/171 (11%)
Query: 489 RIFGGHQGTITCMDLC--KNRLVSGGRDCQVKVWDVDTGKCL------------KTFRHK 534
R+ GHQ +ITC+ + + + S +DC + W V++G+ L K H
Sbjct: 140 RVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHS 199
Query: 535 DPILATRIND--TYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQ--WHLLSG 590
+L I+ Y+ S L+ +W Q + T +GH AV L F + L S
Sbjct: 200 SHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYST 259
Query: 591 STDGLVMAWSMV-GKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRIY 640
S D V W++ Y L + LD V + DG +R++
Sbjct: 260 SHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVW 310
>gi|45594312 TNF receptor-associated factor 7 [Homo sapiens]
Length = 670
Score = 70.1 bits (170), Expect = 1e-11
Identities = 46/146 (31%), Positives = 70/146 (47%), Gaps = 3/146 (2%)
Query: 449 FRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGV-CTRIFGGHQGTITCMDLCKNR 507
F GH G V L + + L SGS D +I+ WD + C + GH G + + + +
Sbjct: 392 FVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCK 451
Query: 508 LVSGGRDCQVKVWDVDTGKCLKTFRHKDPILATRINDTYIVSSCERGLVKVWHIAMAQ-- 565
L SG DC + VWD+ + + T R D + T ++ ++ S +KVW I +
Sbjct: 452 LYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSLKAIKVWDIVGTELK 511
Query: 566 LVKTLSGHEGAVKCLFFDQWHLLSGS 591
L K L+G V+ L Q +L SGS
Sbjct: 512 LKKELTGLNHWVRALVAAQSYLYSGS 537
Score = 64.3 bits (155), Expect = 6e-10
Identities = 45/150 (30%), Positives = 76/150 (50%), Gaps = 15/150 (10%)
Query: 385 NEETQQVLIEERNVFCGTYNVRILSD--TWDQNRVIHYSGGDL--IAVSSNR-------- 432
N + ++ + ++ G+Y + D T D V+ SGG + IAV+++
Sbjct: 520 NHWVRALVAAQSYLYSGSYQTIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYEN 579
Query: 433 KIHLLDIIQVKAIPVEFRGHAGSVRALFLCE--EENFLLSGSYDLSIRYWDLKSGVCTRI 490
IH+ DI + + GH G+V AL + ++ + S SYD S+R W + + +CT+
Sbjct: 580 LIHVWDIESKEQVRT-LTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQT 638
Query: 491 FGGHQGTITCMDLCKNRLVSGGRDCQVKVW 520
HQG++T + + + RL SG D VKVW
Sbjct: 639 LLRHQGSVTALAVSRGRLFSGAVDSTVKVW 668
Score = 61.6 bits (148), Expect = 4e-09
Identities = 45/186 (24%), Positives = 90/186 (48%), Gaps = 9/186 (4%)
Query: 421 SGGDLIAVSSNRKIHLLDIIQVKA-IPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRY 479
S +++ S + I + DI+ + + E G VRAL + ++L SGSY +I+
Sbjct: 487 SSHNVLFSGSLKAIKVWDIVGTELKLKKELTGLNHWVRALVAAQ--SYLYSGSYQ-TIKI 543
Query: 480 WDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPIL 538
WD+++ C + G++ + + + +V G + + VWD+++ + ++T H +
Sbjct: 544 WDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVY 603
Query: 539 ATRI----NDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDG 594
A + + T + S+ ++VW + +TL H+G+V L + L SG+ D
Sbjct: 604 ALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGAVDS 663
Query: 595 LVMAWS 600
V W+
Sbjct: 664 TVKVWT 669
Score = 40.0 bits (92), Expect = 0.012
Identities = 33/117 (28%), Positives = 43/117 (36%), Gaps = 40/117 (34%)
Query: 487 CTRIFGGHQGTITCMDLCK--NRLVSGGRDCQVKVWDVDTGKCLKTFRHKDPILATRIND 544
C F GHQG + C+ + + L SG D +KVWD T
Sbjct: 388 CKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCT-------------------- 427
Query: 545 TYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSM 601
TY C+ KTL GH+G V L L SGS D ++ W +
Sbjct: 428 TY---KCQ---------------KTLEGHDGIVLALCIQGCKLYSGSADCTIIVWDI 466
Score = 31.2 bits (69), Expect = 5.4
Identities = 24/88 (27%), Positives = 40/88 (45%), Gaps = 2/88 (2%)
Query: 569 TLSGHEGAVKCL-FFDQWHLL-SGSTDGLVMAWSMVGKYERCLMAFKHPKEVLDVSLLFL 626
T GH+G V CL + LL SGS+D + W Y+ H VL + +
Sbjct: 391 TFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGC 450
Query: 627 RVISACADGKIRIYNFLNGNCMKVLKAN 654
++ S AD I +++ N + ++A+
Sbjct: 451 KLYSGSADCTIIVWDIQNLQKVNTIRAH 478
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 70.1 bits (170), Expect = 1e-11
Identities = 52/181 (28%), Positives = 83/181 (45%), Gaps = 10/181 (5%)
Query: 451 GHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTI--TCMDLCKNRL 508
GH G VR + + + ++GS D +I+ WDL SG GH T+ + L
Sbjct: 202 GHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYL 261
Query: 509 VSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRINDTY-IVSSCER-GLVKVWHIAMAQ 565
S G D QVK WD++ K ++ + H + ++ T ++ +C R ++W +
Sbjct: 262 FSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKA 321
Query: 566 LVKTLSGHEGA---VKCLFFDQWHLLSGSTDGLVMAWSMVGKYERCLMAFKHPKEVLDVS 622
V TLSGH A V+C + +++GS D + W +V R + H K V V
Sbjct: 322 SVHTLSGHTNAVATVRCQAAEP-QIITGSHDTTIRLWDLVAGKTRVTLT-NHKKSVRAVV 379
Query: 623 L 623
L
Sbjct: 380 L 380
Score = 61.6 bits (148), Expect = 4e-09
Identities = 52/230 (22%), Positives = 100/230 (43%), Gaps = 15/230 (6%)
Query: 425 LIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKS 484
L + ++++ D+ K I + GH +V L L + L++ S D + R WD+++
Sbjct: 261 LFSCGEDKQVKCWDLEYNKVIR-HYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRT 319
Query: 485 GVCTRIFGGHQGTITCM--DLCKNRLVSGGRDCQVKVWDVDTGKCLKTF-RHKDPILATR 541
GH + + + ++++G D +++WD+ GK T HK + A
Sbjct: 320 KASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVV 379
Query: 542 INDT-YIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFD-QWHLLSGSTDGLVMAW 599
++ Y +S +K W ++ LSGH + L + L+SG+ +G + W
Sbjct: 380 LHPRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLW 439
Query: 600 SMVGKYE-RCLMAFKHPKEVLDVSLLFL--------RVISACADGKIRIY 640
Y + + A P + S +F R+++A AD I++Y
Sbjct: 440 DWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVY 489
Score = 61.2 bits (147), Expect = 5e-09
Identities = 42/174 (24%), Positives = 79/174 (45%), Gaps = 8/174 (4%)
Query: 429 SSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCT 488
S++R I + D+ K + + GH +VR + + +L S D ++ WDL+
Sbjct: 223 SADRTIKIWDLASGK-LKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVI 281
Query: 489 RIFGGHQGTITCMDL--CKNRLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRIN-- 543
R + GH + +DL + LV+ RD ++WDV T + T H + + R
Sbjct: 282 RHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAA 341
Query: 544 DTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWH--LLSGSTDGL 595
+ I++ +++W + + TL+ H+ +V+ + H SGS D +
Sbjct: 342 EPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDNI 395
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
[Homo sapiens]
Length = 340
Score = 68.9 bits (167), Expect = 2e-11
Identities = 48/197 (24%), Positives = 84/197 (42%), Gaps = 18/197 (9%)
Query: 413 DQNRVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGS 472
D N+++ SG A+ I+ F GH G V +L L + +SG+
Sbjct: 153 DDNQIVTSSGDTTCALWD---------IETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGA 203
Query: 473 YDLSIRYWDLKSGVCTRIFGGHQGTIT--CMDLCKNRLVSGGRDCQVKVWDVDTGKCLKT 530
D S + WD++ G+C + F GH+ I C N +G D +++D+ + L T
Sbjct: 204 CDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMT 263
Query: 531 FRHKDPI-----LATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFF--D 583
+ H + I ++ + +++ + VW A L+GH+ V CL D
Sbjct: 264 YSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDD 323
Query: 584 QWHLLSGSTDGLVMAWS 600
+ +GS D + W+
Sbjct: 324 GMAVATGSWDSFLKIWN 340
Score = 53.1 bits (126), Expect = 1e-06
Identities = 57/249 (22%), Positives = 107/249 (42%), Gaps = 28/249 (11%)
Query: 425 LIAVSSNRKIHLLDII---QVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWD 481
L++ S + K+ + D +V AIP+ + V N++ G D ++
Sbjct: 70 LVSASQDGKLIIWDSYTTNKVHAIPLR----SSWVMTCAYAPSGNYVACGGLDNICSIYN 125
Query: 482 LKSGV----CTRIFGGHQGTITCMD-LCKNRLVSGGRDCQVKVWDVDTGKCLKTFR-HKD 535
LK+ +R GH G ++C L N++V+ D +WD++TG+ TF H
Sbjct: 126 LKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTG 185
Query: 536 PILATRI-NDT--YIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVK--CLFFDQWHLLSG 590
+++ + DT ++ +C+ K+W + +T +GHE + C F + +G
Sbjct: 186 DVMSLSLAPDTRLFVSGACDAS-AKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATG 244
Query: 591 STDGLVMAWSMVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRI--YNFLNGNCM 648
S D + + E LM + H + ++ +S G++ + Y+ N N
Sbjct: 245 SDDATCRLFDLRADQE--LMTYSHDNIICGIT-----SVSFSKSGRLLLAGYDDFNCNVW 297
Query: 649 KVLKANGRG 657
LKA+ G
Sbjct: 298 DALKADRAG 306
Score = 35.0 bits (79), Expect = 0.37
Identities = 39/208 (18%), Positives = 82/208 (39%), Gaps = 31/208 (14%)
Query: 485 GVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDPILATRI-- 542
G +I+ H GT + + LVS +D ++ +WD T + H P+ ++ +
Sbjct: 53 GHLAKIYAMHWGTDSRL------LVSASQDGKLIIWDSYTTNKV----HAIPLRSSWVMT 102
Query: 543 -----NDTYIVSSCERGLVKVWHIAMAQ----LVKTLSGHEGAVKCL-FFDQWHLLSGST 592
+ Y+ + ++++ + + + L+GH G + C F D +++ S
Sbjct: 103 CAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSG 162
Query: 593 DGLVMAWSMVGKYERCLMAFKHPKEVLDVSL-----LFLRVISACADGKIRIYNFLNGNC 647
D W + + H +V+ +SL LF +S D ++++ G C
Sbjct: 163 DTTCALWDIETGQQTTTFT-GHTGDVMSLSLAPDTRLF---VSGACDASAKLWDVREGMC 218
Query: 648 MKVLKANGRGDPVLSFFIQGNRMVVNTE 675
+ + + FF GN ++
Sbjct: 219 RQTFTGHESDINAICFFPNGNAFATGSD 246
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,248,522
Number of Sequences: 37866
Number of extensions: 1828374
Number of successful extensions: 9601
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 162
Number of HSP's successfully gapped in prelim test: 170
Number of HSP's that attempted gapping in prelim test: 7685
Number of HSP's gapped (non-prelim): 1211
length of query: 1051
length of database: 18,247,518
effective HSP length: 113
effective length of query: 938
effective length of database: 13,968,660
effective search space: 13102603080
effective search space used: 13102603080
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.