Guide to the Human Genome
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Search of human proteins with 169171347

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|169171347 PREDICTED: hypothetical protein [Homo sapiens]
         (1128 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|169171347 PREDICTED: hypothetical protein [Homo sapiens]          2347   0.0  
gi|169172209 PREDICTED: hypothetical protein [Homo sapiens]          1582   0.0  
gi|169170953 PREDICTED: hypothetical protein [Homo sapiens]          1582   0.0  
gi|239508753 PREDICTED: hypothetical protein [Homo sapiens]          1582   0.0  
gi|4826734 fusion (involved in t(12;16) in malignant liposarcoma...    57   1e-07
gi|239750574 PREDICTED: hypothetical protein [Homo sapiens]            55   4e-07
gi|169205732 PREDICTED: hypothetical protein [Homo sapiens]            55   4e-07
gi|111118976 collagen, type II, alpha 1 isoform 1 precursor [Hom...    54   6e-07
gi|111118974 collagen, type II, alpha 1 isoform 2 precursor [Hom...    54   6e-07
gi|57864582 hornerin [Homo sapiens]                                    53   1e-06
gi|40068464 AT rich interactive domain 1B (SWI1-like) isoform 2 ...    53   2e-06
gi|40068466 AT rich interactive domain 1B (SWI1-like) isoform 1 ...    53   2e-06
gi|40068462 AT rich interactive domain 1B (SWI1-like) isoform 3 ...    53   2e-06
gi|239755920 PREDICTED: hypothetical protein XP_002344746 [Homo ...    52   3e-06
gi|239750393 PREDICTED: hypothetical protein [Homo sapiens]            52   3e-06
gi|239744740 PREDICTED: hypothetical protein XP_002343259 [Homo ...    52   3e-06
gi|239744694 PREDICTED: hypothetical protein [Homo sapiens]            52   3e-06
gi|169204930 PREDICTED: hypothetical protein [Homo sapiens]            51   7e-06
gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens]      50   9e-06
gi|48762934 alpha 2 type I collagen [Homo sapiens]                     50   1e-05
gi|239758013 PREDICTED: hypothetical protein [Homo sapiens]            50   2e-05
gi|11386161 alpha 2 type IX collagen [Homo sapiens]                    49   2e-05
gi|4504733 insulin receptor substrate 4 [Homo sapiens]                 49   3e-05
gi|109452587 family with sequence similarity 98, member B isofor...    49   3e-05
gi|4502951 collagen type III alpha 1 preproprotein [Homo sapiens]      48   5e-05
gi|187828892 calcium channel, alpha 1A subunit isoform 4 [Homo s...    48   6e-05
gi|89363017 alpha 2 type V collagen preproprotein [Homo sapiens]       47   8e-05
gi|51702521 POU domain, class 3, transcription factor 2 [Homo sa...    47   8e-05
gi|239750438 PREDICTED: hypothetical protein [Homo sapiens]            47   1e-04
gi|25777671 protein phosphatase 1, regulatory subunit 10 [Homo s...    46   2e-04

>gi|169171347 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 1128

 Score = 2347 bits (6083), Expect = 0.0
 Identities = 1128/1128 (100%), Positives = 1128/1128 (100%)

Query: 1    MVDHMGWVCTDNESSLGLSASKFIILSDSAGPNPLTQKTESNPVVWALPHDPRGWRLRPL 60
            MVDHMGWVCTDNESSLGLSASKFIILSDSAGPNPLTQKTESNPVVWALPHDPRGWRLRPL
Sbjct: 1    MVDHMGWVCTDNESSLGLSASKFIILSDSAGPNPLTQKTESNPVVWALPHDPRGWRLRPL 60

Query: 61   QTAASLPFFPASHSLSLSQGVATVCYKFYLSSVQERREEALSQLRACLSPRTPIKGTNWT 120
            QTAASLPFFPASHSLSLSQGVATVCYKFYLSSVQERREEALSQLRACLSPRTPIKGTNWT
Sbjct: 61   QTAASLPFFPASHSLSLSQGVATVCYKFYLSSVQERREEALSQLRACLSPRTPIKGTNWT 120

Query: 121  AIHQSRSREGASHGKGSGPEGREATRARFPSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQ 180
            AIHQSRSREGASHGKGSGPEGREATRARFPSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQ
Sbjct: 121  AIHQSRSREGASHGKGSGPEGREATRARFPSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQ 180

Query: 181  SPEATSNLCRARNEAFRLQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDVLQSASGGSL 240
            SPEATSNLCRARNEAFRLQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDVLQSASGGSL
Sbjct: 181  SPEATSNLCRARNEAFRLQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDVLQSASGGSL 240

Query: 241  FLGLPSPGHTRPLPARGRREPEAGESEARPESPPQPQPRRRLARRGPSASPGSWGESHPQ 300
            FLGLPSPGHTRPLPARGRREPEAGESEARPESPPQPQPRRRLARRGPSASPGSWGESHPQ
Sbjct: 241  FLGLPSPGHTRPLPARGRREPEAGESEARPESPPQPQPRRRLARRGPSASPGSWGESHPQ 300

Query: 301  DDFQYEDNSDQDDPNQGAFLPAVLHPQVQTQFDQKTQVSALSSGVSGQLHGDHYYTFNIH 360
            DDFQYEDNSDQDDPNQGAFLPAVLHPQVQTQFDQKTQVSALSSGVSGQLHGDHYYTFNIH
Sbjct: 301  DDFQYEDNSDQDDPNQGAFLPAVLHPQVQTQFDQKTQVSALSSGVSGQLHGDHYYTFNIH 360

Query: 361  KPSSHTSLANQGARSEERGARLAESRGRGVTPRASWSRQPAGGPLSSEGHLLPLVQRDGG 420
            KPSSHTSLANQGARSEERGARLAESRGRGVTPRASWSRQPAGGPLSSEGHLLPLVQRDGG
Sbjct: 361  KPSSHTSLANQGARSEERGARLAESRGRGVTPRASWSRQPAGGPLSSEGHLLPLVQRDGG 420

Query: 421  GLAEHRGREGEEGVRAGGGGTGEVRGGGSPGRQPVGRAAVTGEAGAGAAGRGAQSVRGPG 480
            GLAEHRGREGEEGVRAGGGGTGEVRGGGSPGRQPVGRAAVTGEAGAGAAGRGAQSVRGPG
Sbjct: 421  GLAEHRGREGEEGVRAGGGGTGEVRGGGSPGRQPVGRAAVTGEAGAGAAGRGAQSVRGPG 480

Query: 481  VERRVAEGAQQFGPRVGLRQHAERVERAQRAAEGRGGGGGGGCGAQAHRRVVGQGQVRWE 540
            VERRVAEGAQQFGPRVGLRQHAERVERAQRAAEGRGGGGGGGCGAQAHRRVVGQGQVRWE
Sbjct: 481  VERRVAEGAQQFGPRVGLRQHAERVERAQRAAEGRGGGGGGGCGAQAHRRVVGQGQVRWE 540

Query: 541  GVGQAARGRRMAHHCSQGRNSQSRHQPGRDRPHHHHLELESLRERVPCEPPPPLPPLLLG 600
            GVGQAARGRRMAHHCSQGRNSQSRHQPGRDRPHHHHLELESLRERVPCEPPPPLPPLLLG
Sbjct: 541  GVGQAARGRRMAHHCSQGRNSQSRHQPGRDRPHHHHLELESLRERVPCEPPPPLPPLLLG 600

Query: 601  VSLPPFGLPTSASEPDPAQRVQSTGVYRHRHTNAIEVGLPGSDKVIWTSDRRANWSEGCS 660
            VSLPPFGLPTSASEPDPAQRVQSTGVYRHRHTNAIEVGLPGSDKVIWTSDRRANWSEGCS
Sbjct: 601  VSLPPFGLPTSASEPDPAQRVQSTGVYRHRHTNAIEVGLPGSDKVIWTSDRRANWSEGCS 660

Query: 661  TRAAQVGRNFTVLYGLLASAPPCLLHPASHKLPGSAFDLALAWGKCLPRAIEAFPEQLKH 720
            TRAAQVGRNFTVLYGLLASAPPCLLHPASHKLPGSAFDLALAWGKCLPRAIEAFPEQLKH
Sbjct: 661  TRAAQVGRNFTVLYGLLASAPPCLLHPASHKLPGSAFDLALAWGKCLPRAIEAFPEQLKH 720

Query: 721  WVLGVSFESPKSRTCIRPLSTPHSRHCCHPQSRQCQNTVGDPRQNADSRESCSVPLVTPL 780
            WVLGVSFESPKSRTCIRPLSTPHSRHCCHPQSRQCQNTVGDPRQNADSRESCSVPLVTPL
Sbjct: 721  WVLGVSFESPKSRTCIRPLSTPHSRHCCHPQSRQCQNTVGDPRQNADSRESCSVPLVTPL 780

Query: 781  GERKWINRNVCHSEDERKPAANGSAVMRQMALSFPQPGFILRWLFVQEVAFPFAWTSPAL 840
            GERKWINRNVCHSEDERKPAANGSAVMRQMALSFPQPGFILRWLFVQEVAFPFAWTSPAL
Sbjct: 781  GERKWINRNVCHSEDERKPAANGSAVMRQMALSFPQPGFILRWLFVQEVAFPFAWTSPAL 840

Query: 841  QSLPRGSGTCLQKWMAFEVEESEVAENALKQQSKTMFINLAWGRRQRDPEVESAEKVGGS 900
            QSLPRGSGTCLQKWMAFEVEESEVAENALKQQSKTMFINLAWGRRQRDPEVESAEKVGGS
Sbjct: 841  QSLPRGSGTCLQKWMAFEVEESEVAENALKQQSKTMFINLAWGRRQRDPEVESAEKVGGS 900

Query: 901  CVTVAGTVEHFLLQTGGNCGFWNSDFEECPLLSTLLEWRASPLPWGTISTLFHPCTWVGR 960
            CVTVAGTVEHFLLQTGGNCGFWNSDFEECPLLSTLLEWRASPLPWGTISTLFHPCTWVGR
Sbjct: 901  CVTVAGTVEHFLLQTGGNCGFWNSDFEECPLLSTLLEWRASPLPWGTISTLFHPCTWVGR 960

Query: 961  MRPLSPRAVSDAREPGEVGIRGARHEGRVAHREGPQGAATWRDCAIPAQKPGGESVRVSF 1020
            MRPLSPRAVSDAREPGEVGIRGARHEGRVAHREGPQGAATWRDCAIPAQKPGGESVRVSF
Sbjct: 961  MRPLSPRAVSDAREPGEVGIRGARHEGRVAHREGPQGAATWRDCAIPAQKPGGESVRVSF 1020

Query: 1021 RGCCLEPLEGPFPSWELVGRLVLSPRPLSAPSAPRRLGDKAQLPNCCLGAPPTADRQRRK 1080
            RGCCLEPLEGPFPSWELVGRLVLSPRPLSAPSAPRRLGDKAQLPNCCLGAPPTADRQRRK
Sbjct: 1021 RGCCLEPLEGPFPSWELVGRLVLSPRPLSAPSAPRRLGDKAQLPNCCLGAPPTADRQRRK 1080

Query: 1081 SRRVPASLLARIPRLCPEQRPQSPIPRGQPVPPGPMRPLSELDPKRDG 1128
            SRRVPASLLARIPRLCPEQRPQSPIPRGQPVPPGPMRPLSELDPKRDG
Sbjct: 1081 SRRVPASLLARIPRLCPEQRPQSPIPRGQPVPPGPMRPLSELDPKRDG 1128


>gi|169172209 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 801

 Score = 1582 bits (4096), Expect = 0.0
 Identities = 757/757 (100%), Positives = 757/757 (100%)

Query: 372  GARSEERGARLAESRGRGVTPRASWSRQPAGGPLSSEGHLLPLVQRDGGGLAEHRGREGE 431
            GARSEERGARLAESRGRGVTPRASWSRQPAGGPLSSEGHLLPLVQRDGGGLAEHRGREGE
Sbjct: 45   GARSEERGARLAESRGRGVTPRASWSRQPAGGPLSSEGHLLPLVQRDGGGLAEHRGREGE 104

Query: 432  EGVRAGGGGTGEVRGGGSPGRQPVGRAAVTGEAGAGAAGRGAQSVRGPGVERRVAEGAQQ 491
            EGVRAGGGGTGEVRGGGSPGRQPVGRAAVTGEAGAGAAGRGAQSVRGPGVERRVAEGAQQ
Sbjct: 105  EGVRAGGGGTGEVRGGGSPGRQPVGRAAVTGEAGAGAAGRGAQSVRGPGVERRVAEGAQQ 164

Query: 492  FGPRVGLRQHAERVERAQRAAEGRGGGGGGGCGAQAHRRVVGQGQVRWEGVGQAARGRRM 551
            FGPRVGLRQHAERVERAQRAAEGRGGGGGGGCGAQAHRRVVGQGQVRWEGVGQAARGRRM
Sbjct: 165  FGPRVGLRQHAERVERAQRAAEGRGGGGGGGCGAQAHRRVVGQGQVRWEGVGQAARGRRM 224

Query: 552  AHHCSQGRNSQSRHQPGRDRPHHHHLELESLRERVPCEPPPPLPPLLLGVSLPPFGLPTS 611
            AHHCSQGRNSQSRHQPGRDRPHHHHLELESLRERVPCEPPPPLPPLLLGVSLPPFGLPTS
Sbjct: 225  AHHCSQGRNSQSRHQPGRDRPHHHHLELESLRERVPCEPPPPLPPLLLGVSLPPFGLPTS 284

Query: 612  ASEPDPAQRVQSTGVYRHRHTNAIEVGLPGSDKVIWTSDRRANWSEGCSTRAAQVGRNFT 671
            ASEPDPAQRVQSTGVYRHRHTNAIEVGLPGSDKVIWTSDRRANWSEGCSTRAAQVGRNFT
Sbjct: 285  ASEPDPAQRVQSTGVYRHRHTNAIEVGLPGSDKVIWTSDRRANWSEGCSTRAAQVGRNFT 344

Query: 672  VLYGLLASAPPCLLHPASHKLPGSAFDLALAWGKCLPRAIEAFPEQLKHWVLGVSFESPK 731
            VLYGLLASAPPCLLHPASHKLPGSAFDLALAWGKCLPRAIEAFPEQLKHWVLGVSFESPK
Sbjct: 345  VLYGLLASAPPCLLHPASHKLPGSAFDLALAWGKCLPRAIEAFPEQLKHWVLGVSFESPK 404

Query: 732  SRTCIRPLSTPHSRHCCHPQSRQCQNTVGDPRQNADSRESCSVPLVTPLGERKWINRNVC 791
            SRTCIRPLSTPHSRHCCHPQSRQCQNTVGDPRQNADSRESCSVPLVTPLGERKWINRNVC
Sbjct: 405  SRTCIRPLSTPHSRHCCHPQSRQCQNTVGDPRQNADSRESCSVPLVTPLGERKWINRNVC 464

Query: 792  HSEDERKPAANGSAVMRQMALSFPQPGFILRWLFVQEVAFPFAWTSPALQSLPRGSGTCL 851
            HSEDERKPAANGSAVMRQMALSFPQPGFILRWLFVQEVAFPFAWTSPALQSLPRGSGTCL
Sbjct: 465  HSEDERKPAANGSAVMRQMALSFPQPGFILRWLFVQEVAFPFAWTSPALQSLPRGSGTCL 524

Query: 852  QKWMAFEVEESEVAENALKQQSKTMFINLAWGRRQRDPEVESAEKVGGSCVTVAGTVEHF 911
            QKWMAFEVEESEVAENALKQQSKTMFINLAWGRRQRDPEVESAEKVGGSCVTVAGTVEHF
Sbjct: 525  QKWMAFEVEESEVAENALKQQSKTMFINLAWGRRQRDPEVESAEKVGGSCVTVAGTVEHF 584

Query: 912  LLQTGGNCGFWNSDFEECPLLSTLLEWRASPLPWGTISTLFHPCTWVGRMRPLSPRAVSD 971
            LLQTGGNCGFWNSDFEECPLLSTLLEWRASPLPWGTISTLFHPCTWVGRMRPLSPRAVSD
Sbjct: 585  LLQTGGNCGFWNSDFEECPLLSTLLEWRASPLPWGTISTLFHPCTWVGRMRPLSPRAVSD 644

Query: 972  AREPGEVGIRGARHEGRVAHREGPQGAATWRDCAIPAQKPGGESVRVSFRGCCLEPLEGP 1031
            AREPGEVGIRGARHEGRVAHREGPQGAATWRDCAIPAQKPGGESVRVSFRGCCLEPLEGP
Sbjct: 645  AREPGEVGIRGARHEGRVAHREGPQGAATWRDCAIPAQKPGGESVRVSFRGCCLEPLEGP 704

Query: 1032 FPSWELVGRLVLSPRPLSAPSAPRRLGDKAQLPNCCLGAPPTADRQRRKSRRVPASLLAR 1091
            FPSWELVGRLVLSPRPLSAPSAPRRLGDKAQLPNCCLGAPPTADRQRRKSRRVPASLLAR
Sbjct: 705  FPSWELVGRLVLSPRPLSAPSAPRRLGDKAQLPNCCLGAPPTADRQRRKSRRVPASLLAR 764

Query: 1092 IPRLCPEQRPQSPIPRGQPVPPGPMRPLSELDPKRDG 1128
            IPRLCPEQRPQSPIPRGQPVPPGPMRPLSELDPKRDG
Sbjct: 765  IPRLCPEQRPQSPIPRGQPVPPGPMRPLSELDPKRDG 801


>gi|169170953 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 801

 Score = 1582 bits (4096), Expect = 0.0
 Identities = 757/757 (100%), Positives = 757/757 (100%)

Query: 372  GARSEERGARLAESRGRGVTPRASWSRQPAGGPLSSEGHLLPLVQRDGGGLAEHRGREGE 431
            GARSEERGARLAESRGRGVTPRASWSRQPAGGPLSSEGHLLPLVQRDGGGLAEHRGREGE
Sbjct: 45   GARSEERGARLAESRGRGVTPRASWSRQPAGGPLSSEGHLLPLVQRDGGGLAEHRGREGE 104

Query: 432  EGVRAGGGGTGEVRGGGSPGRQPVGRAAVTGEAGAGAAGRGAQSVRGPGVERRVAEGAQQ 491
            EGVRAGGGGTGEVRGGGSPGRQPVGRAAVTGEAGAGAAGRGAQSVRGPGVERRVAEGAQQ
Sbjct: 105  EGVRAGGGGTGEVRGGGSPGRQPVGRAAVTGEAGAGAAGRGAQSVRGPGVERRVAEGAQQ 164

Query: 492  FGPRVGLRQHAERVERAQRAAEGRGGGGGGGCGAQAHRRVVGQGQVRWEGVGQAARGRRM 551
            FGPRVGLRQHAERVERAQRAAEGRGGGGGGGCGAQAHRRVVGQGQVRWEGVGQAARGRRM
Sbjct: 165  FGPRVGLRQHAERVERAQRAAEGRGGGGGGGCGAQAHRRVVGQGQVRWEGVGQAARGRRM 224

Query: 552  AHHCSQGRNSQSRHQPGRDRPHHHHLELESLRERVPCEPPPPLPPLLLGVSLPPFGLPTS 611
            AHHCSQGRNSQSRHQPGRDRPHHHHLELESLRERVPCEPPPPLPPLLLGVSLPPFGLPTS
Sbjct: 225  AHHCSQGRNSQSRHQPGRDRPHHHHLELESLRERVPCEPPPPLPPLLLGVSLPPFGLPTS 284

Query: 612  ASEPDPAQRVQSTGVYRHRHTNAIEVGLPGSDKVIWTSDRRANWSEGCSTRAAQVGRNFT 671
            ASEPDPAQRVQSTGVYRHRHTNAIEVGLPGSDKVIWTSDRRANWSEGCSTRAAQVGRNFT
Sbjct: 285  ASEPDPAQRVQSTGVYRHRHTNAIEVGLPGSDKVIWTSDRRANWSEGCSTRAAQVGRNFT 344

Query: 672  VLYGLLASAPPCLLHPASHKLPGSAFDLALAWGKCLPRAIEAFPEQLKHWVLGVSFESPK 731
            VLYGLLASAPPCLLHPASHKLPGSAFDLALAWGKCLPRAIEAFPEQLKHWVLGVSFESPK
Sbjct: 345  VLYGLLASAPPCLLHPASHKLPGSAFDLALAWGKCLPRAIEAFPEQLKHWVLGVSFESPK 404

Query: 732  SRTCIRPLSTPHSRHCCHPQSRQCQNTVGDPRQNADSRESCSVPLVTPLGERKWINRNVC 791
            SRTCIRPLSTPHSRHCCHPQSRQCQNTVGDPRQNADSRESCSVPLVTPLGERKWINRNVC
Sbjct: 405  SRTCIRPLSTPHSRHCCHPQSRQCQNTVGDPRQNADSRESCSVPLVTPLGERKWINRNVC 464

Query: 792  HSEDERKPAANGSAVMRQMALSFPQPGFILRWLFVQEVAFPFAWTSPALQSLPRGSGTCL 851
            HSEDERKPAANGSAVMRQMALSFPQPGFILRWLFVQEVAFPFAWTSPALQSLPRGSGTCL
Sbjct: 465  HSEDERKPAANGSAVMRQMALSFPQPGFILRWLFVQEVAFPFAWTSPALQSLPRGSGTCL 524

Query: 852  QKWMAFEVEESEVAENALKQQSKTMFINLAWGRRQRDPEVESAEKVGGSCVTVAGTVEHF 911
            QKWMAFEVEESEVAENALKQQSKTMFINLAWGRRQRDPEVESAEKVGGSCVTVAGTVEHF
Sbjct: 525  QKWMAFEVEESEVAENALKQQSKTMFINLAWGRRQRDPEVESAEKVGGSCVTVAGTVEHF 584

Query: 912  LLQTGGNCGFWNSDFEECPLLSTLLEWRASPLPWGTISTLFHPCTWVGRMRPLSPRAVSD 971
            LLQTGGNCGFWNSDFEECPLLSTLLEWRASPLPWGTISTLFHPCTWVGRMRPLSPRAVSD
Sbjct: 585  LLQTGGNCGFWNSDFEECPLLSTLLEWRASPLPWGTISTLFHPCTWVGRMRPLSPRAVSD 644

Query: 972  AREPGEVGIRGARHEGRVAHREGPQGAATWRDCAIPAQKPGGESVRVSFRGCCLEPLEGP 1031
            AREPGEVGIRGARHEGRVAHREGPQGAATWRDCAIPAQKPGGESVRVSFRGCCLEPLEGP
Sbjct: 645  AREPGEVGIRGARHEGRVAHREGPQGAATWRDCAIPAQKPGGESVRVSFRGCCLEPLEGP 704

Query: 1032 FPSWELVGRLVLSPRPLSAPSAPRRLGDKAQLPNCCLGAPPTADRQRRKSRRVPASLLAR 1091
            FPSWELVGRLVLSPRPLSAPSAPRRLGDKAQLPNCCLGAPPTADRQRRKSRRVPASLLAR
Sbjct: 705  FPSWELVGRLVLSPRPLSAPSAPRRLGDKAQLPNCCLGAPPTADRQRRKSRRVPASLLAR 764

Query: 1092 IPRLCPEQRPQSPIPRGQPVPPGPMRPLSELDPKRDG 1128
            IPRLCPEQRPQSPIPRGQPVPPGPMRPLSELDPKRDG
Sbjct: 765  IPRLCPEQRPQSPIPRGQPVPPGPMRPLSELDPKRDG 801


>gi|239508753 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 801

 Score = 1582 bits (4096), Expect = 0.0
 Identities = 757/757 (100%), Positives = 757/757 (100%)

Query: 372  GARSEERGARLAESRGRGVTPRASWSRQPAGGPLSSEGHLLPLVQRDGGGLAEHRGREGE 431
            GARSEERGARLAESRGRGVTPRASWSRQPAGGPLSSEGHLLPLVQRDGGGLAEHRGREGE
Sbjct: 45   GARSEERGARLAESRGRGVTPRASWSRQPAGGPLSSEGHLLPLVQRDGGGLAEHRGREGE 104

Query: 432  EGVRAGGGGTGEVRGGGSPGRQPVGRAAVTGEAGAGAAGRGAQSVRGPGVERRVAEGAQQ 491
            EGVRAGGGGTGEVRGGGSPGRQPVGRAAVTGEAGAGAAGRGAQSVRGPGVERRVAEGAQQ
Sbjct: 105  EGVRAGGGGTGEVRGGGSPGRQPVGRAAVTGEAGAGAAGRGAQSVRGPGVERRVAEGAQQ 164

Query: 492  FGPRVGLRQHAERVERAQRAAEGRGGGGGGGCGAQAHRRVVGQGQVRWEGVGQAARGRRM 551
            FGPRVGLRQHAERVERAQRAAEGRGGGGGGGCGAQAHRRVVGQGQVRWEGVGQAARGRRM
Sbjct: 165  FGPRVGLRQHAERVERAQRAAEGRGGGGGGGCGAQAHRRVVGQGQVRWEGVGQAARGRRM 224

Query: 552  AHHCSQGRNSQSRHQPGRDRPHHHHLELESLRERVPCEPPPPLPPLLLGVSLPPFGLPTS 611
            AHHCSQGRNSQSRHQPGRDRPHHHHLELESLRERVPCEPPPPLPPLLLGVSLPPFGLPTS
Sbjct: 225  AHHCSQGRNSQSRHQPGRDRPHHHHLELESLRERVPCEPPPPLPPLLLGVSLPPFGLPTS 284

Query: 612  ASEPDPAQRVQSTGVYRHRHTNAIEVGLPGSDKVIWTSDRRANWSEGCSTRAAQVGRNFT 671
            ASEPDPAQRVQSTGVYRHRHTNAIEVGLPGSDKVIWTSDRRANWSEGCSTRAAQVGRNFT
Sbjct: 285  ASEPDPAQRVQSTGVYRHRHTNAIEVGLPGSDKVIWTSDRRANWSEGCSTRAAQVGRNFT 344

Query: 672  VLYGLLASAPPCLLHPASHKLPGSAFDLALAWGKCLPRAIEAFPEQLKHWVLGVSFESPK 731
            VLYGLLASAPPCLLHPASHKLPGSAFDLALAWGKCLPRAIEAFPEQLKHWVLGVSFESPK
Sbjct: 345  VLYGLLASAPPCLLHPASHKLPGSAFDLALAWGKCLPRAIEAFPEQLKHWVLGVSFESPK 404

Query: 732  SRTCIRPLSTPHSRHCCHPQSRQCQNTVGDPRQNADSRESCSVPLVTPLGERKWINRNVC 791
            SRTCIRPLSTPHSRHCCHPQSRQCQNTVGDPRQNADSRESCSVPLVTPLGERKWINRNVC
Sbjct: 405  SRTCIRPLSTPHSRHCCHPQSRQCQNTVGDPRQNADSRESCSVPLVTPLGERKWINRNVC 464

Query: 792  HSEDERKPAANGSAVMRQMALSFPQPGFILRWLFVQEVAFPFAWTSPALQSLPRGSGTCL 851
            HSEDERKPAANGSAVMRQMALSFPQPGFILRWLFVQEVAFPFAWTSPALQSLPRGSGTCL
Sbjct: 465  HSEDERKPAANGSAVMRQMALSFPQPGFILRWLFVQEVAFPFAWTSPALQSLPRGSGTCL 524

Query: 852  QKWMAFEVEESEVAENALKQQSKTMFINLAWGRRQRDPEVESAEKVGGSCVTVAGTVEHF 911
            QKWMAFEVEESEVAENALKQQSKTMFINLAWGRRQRDPEVESAEKVGGSCVTVAGTVEHF
Sbjct: 525  QKWMAFEVEESEVAENALKQQSKTMFINLAWGRRQRDPEVESAEKVGGSCVTVAGTVEHF 584

Query: 912  LLQTGGNCGFWNSDFEECPLLSTLLEWRASPLPWGTISTLFHPCTWVGRMRPLSPRAVSD 971
            LLQTGGNCGFWNSDFEECPLLSTLLEWRASPLPWGTISTLFHPCTWVGRMRPLSPRAVSD
Sbjct: 585  LLQTGGNCGFWNSDFEECPLLSTLLEWRASPLPWGTISTLFHPCTWVGRMRPLSPRAVSD 644

Query: 972  AREPGEVGIRGARHEGRVAHREGPQGAATWRDCAIPAQKPGGESVRVSFRGCCLEPLEGP 1031
            AREPGEVGIRGARHEGRVAHREGPQGAATWRDCAIPAQKPGGESVRVSFRGCCLEPLEGP
Sbjct: 645  AREPGEVGIRGARHEGRVAHREGPQGAATWRDCAIPAQKPGGESVRVSFRGCCLEPLEGP 704

Query: 1032 FPSWELVGRLVLSPRPLSAPSAPRRLGDKAQLPNCCLGAPPTADRQRRKSRRVPASLLAR 1091
            FPSWELVGRLVLSPRPLSAPSAPRRLGDKAQLPNCCLGAPPTADRQRRKSRRVPASLLAR
Sbjct: 705  FPSWELVGRLVLSPRPLSAPSAPRRLGDKAQLPNCCLGAPPTADRQRRKSRRVPASLLAR 764

Query: 1092 IPRLCPEQRPQSPIPRGQPVPPGPMRPLSELDPKRDG 1128
            IPRLCPEQRPQSPIPRGQPVPPGPMRPLSELDPKRDG
Sbjct: 765  IPRLCPEQRPQSPIPRGQPVPPGPMRPLSELDPKRDG 801


>gi|4826734 fusion (involved in t(12;16) in malignant liposarcoma)
           [Homo sapiens]
          Length = 526

 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 67/264 (25%), Positives = 104/264 (39%), Gaps = 42/264 (15%)

Query: 336 TQVSALSSGVSGQLHGDHYYTFNIHKPSSHTSLANQGARSEERGA--RLAESRGRGVTPR 393
           TQ +    G +G          +  + SS+     Q A S   G+    ++S   G    
Sbjct: 68  TQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQS 127

Query: 394 ASWSRQPA-GGPLSSEGHLLPLVQRDGGGLAEHRGREGEEGVRAGGGGTGEVRGGGSPGR 452
            S+S+QP+ GG   S G      Q+      +  G++ +    +GGGG     GGG  G 
Sbjct: 128 GSYSQQPSYGGQQQSYG------QQQSYNPPQGYGQQNQYNSSSGGGG-----GGGGGGN 176

Query: 453 QPVGRAAVTGEAGAGAAGRGAQSVRGPGVERRVAEGAQQFGPRVGLRQHAERVERAQRAA 512
               +++++   G+G  G G Q   G G       G+  +G +              R  
Sbjct: 177 YGQDQSSMSSGGGSGG-GYGNQDQSGGG-------GSGGYGQQ-------------DRGG 215

Query: 513 EGRGG-GGGGGCGAQAHRRVVGQGQVRWEGVGQAARG------RRMAHHCSQGRNSQSRH 565
            GRGG GGGGG G   + R  G  + R  G G+  RG      R   +     R+  SRH
Sbjct: 216 RGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFNKFGGPRDQGSRH 275

Query: 566 QPGRDRPHHHHLELESLRERVPCE 589
              +D   ++ + ++ L E V  E
Sbjct: 276 DSEQDNSDNNTIFVQGLGENVTIE 299



 Score = 30.4 bits (67), Expect = 9.9
 Identities = 37/125 (29%), Positives = 43/125 (34%), Gaps = 17/125 (13%)

Query: 417 RDGGGLAEHRGREGEEGVRAGGGGTG--EVRGGGSPGRQPVG------------RAAVTG 462
           R G G     GR G  G  +GGGG G     GGG  G+Q  G              +   
Sbjct: 383 RGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRN 442

Query: 463 EAGAGAAGRGAQSVRGPGVERRVAE-GAQQFGPRVGLRQHAERVERAQRAA--EGRGGGG 519
           E     A +      GPG        G  + G R G  +   R     R     GRGGG 
Sbjct: 443 ECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGGYRGRGGDRGGFRGGRGGGD 502

Query: 520 GGGCG 524
            GG G
Sbjct: 503 RGGFG 507


>gi|239750574 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 1297

 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 64/208 (30%), Positives = 80/208 (38%), Gaps = 25/208 (12%)

Query: 367  SLANQGARSEERGARLAESRGRGVTPRASWSRQPAGGPLSSEGHLLPLVQRDGGGLAEHR 426
            S+A +GA+    GA L +    GV   A      AGGPL+         +R   G     
Sbjct: 801  SVAAEGAQVAWAGAVLVQGHEAGVAGGARGGGAAAGGPLAGAVVQRMRQRRVRAGRRRVG 860

Query: 427  GR----EGEEGVRAGGGGT----GEVRGGGSPGRQPVGRAAVTGEAGAGAAGRGAQSVRG 478
             R     G +G  AGGGG     G   G     R P  +      A A AA +G ++ +G
Sbjct: 861  ARAVAAAGRQGAGAGGGGRRVRHGHGHGAAVLQRAPCRQQRHLAPAAAAAAAQGVRAAQG 920

Query: 479  PGVERRVAEGAQQFGPRVGLRQHAERVERA---------QRAAEGRGGGGGGGCGAQ-AH 528
                R  A+GA     R G R    R   A          RAA GR  GGG   GA+ AH
Sbjct: 921  -RAHRPGAQGAPSHRHRPGARGRRSRRRAAVALAGGAHPARAALGRRRGGGQAVGARAAH 979

Query: 529  RRVVGQGQV------RWEGVGQAARGRR 550
            +  +  GQV         G     RGRR
Sbjct: 980  QARLAGGQVDQVVVAARAGDADGVRGRR 1007



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 65/217 (29%), Positives = 80/217 (36%), Gaps = 45/217 (20%)

Query: 386 RGRGVTPRASWS--------RQPAGGPLSS-----EGHLLPLVQRDGGGLAEHRGREGEE 432
           RG+GV P A  S        R PA G  +       GH+   V+         RGR  + 
Sbjct: 738 RGQGVGPLAQPSVQVLGRVPRDPAVGAATVAQGPVHGHVP--VELTAAAAVSGRGRLRD- 794

Query: 433 GVRAGGGGTGEVRGGGSPGRQPVGRAAVT---GEAGAGAAGRGAQSVRGPGVERRVAEGA 489
                  G G V    + G Q     AV     EAG     RG  +  G  +   V +  
Sbjct: 795 -------GLGRVASVAAEGAQVAWAGAVLVQGHEAGVAGGARGGGAAAGGPLAGAVVQRM 847

Query: 490 QQFGPRVGLRQHAERVERAQRAAEGRGGGGGGGCGAQAHRRVVGQGQVRWEGVGQAARGR 549
           +Q   R G R    RV     AA GR G G GG G     R V  G      V Q A  R
Sbjct: 848 RQRRVRAGRR----RVGARAVAAAGRQGAGAGGGG-----RRVRHGHGHGAAVLQRAPCR 898

Query: 550 RMAH-------HCSQG-RNSQSR-HQPG-RDRPHHHH 576
           +  H         +QG R +Q R H+PG +  P H H
Sbjct: 899 QQRHLAPAAAAAAAQGVRAAQGRAHRPGAQGAPSHRH 935



 Score = 34.7 bits (78), Expect = 0.52
 Identities = 106/395 (26%), Positives = 132/395 (33%), Gaps = 75/395 (18%)

Query: 208 GQTQARGYEPRTGRDGDPG---TNWDVLQSASGGSLFLGLPSPGHT-RPLP--ARGRREP 261
           G+ + R    R  R   PG    + DVL  A G      L   G   +PL   ARG   P
Sbjct: 373 GRGRRRQQGRRGRRQAGPGLAKVDVDVLAGALGLRWQWVLVHAGQAGQPLQGQARGPHRP 432

Query: 262 EAGESEARPESPPQPQPRRRLARRG-PSASPGSWGE-SHPQDDFQYEDNSDQDDPNQGAF 319
            A   EA   +  +P  RR    RG   A P   G  + P    + +    QD P+ GA 
Sbjct: 433 AALAQEALRAAAARPHGRRHYRVRGLRGAGPEGAGRLAGPWRGLRLQTLLLQDAPHGGAH 492

Query: 320 LPAVLHPQVQTQFDQKTQVSALSSGVSGQLHGDHYYTFNIHKPSSHTSLANQGARSEE-R 378
                         +   V+  ++GV G +                     QG   E  R
Sbjct: 493 --------------EHVLVAVPATGVGGLVGAGQGAVAAAGNAPERLPAGVQGCGEEVGR 538

Query: 379 GAR-----------------LAESRGRGVTPRASWSRQPA--GGPLSSEGHLL------- 412
           GAR                 LA     G    A  +  P   GG L     L+       
Sbjct: 539 GARGDRVAGGHVEVVPVGQQLAICMLHGQLGTAPHAHVPTVLGGALGGRAGLVAAPARRE 598

Query: 413 -PLVQRDGGGLAEHRGREGEEGVRAGGGGTG--EVRG----GGSPGRQPVGRAAVTGEAG 465
            P  +R G      R R G  G   GGGG G  ++ G    GG+ G   V  AA    A 
Sbjct: 599 CPARRRGGCWPRRPRRRHGGGG---GGGGPGLQDLLGGGHAGGAHGHVVVAPAAAAPTAR 655

Query: 466 AGAAGR-GAQSVRGPGVERRVAEGAQ---QFGPRVGLRQHAERVERAQRAAEGRGGGGGG 521
            G AGR G  +V  P V      GA         VG+  H  R   A RA   R    GG
Sbjct: 656 EGRAGRHGHVAVVCPQVAAGAPVGADLDVSVVLWVGVVGHLGRGRGAGRAEAARAAREGG 715

Query: 522 ---------GCGAQAHRRVVGQGQVRWEGVGQAAR 547
                    G G   HR + G    R +GVG  A+
Sbjct: 716 PHQGVFIQRGRGGLGHRPLPGW---RGQGVGPLAQ 747



 Score = 34.3 bits (77), Expect = 0.69
 Identities = 85/361 (23%), Positives = 121/361 (33%), Gaps = 55/361 (15%)

Query: 248 GHTRPLPARGRREPEAGESEA-------RPESPPQPQPRRRLA--------------RRG 286
           G +  L A G R P++G SE        RP  PP  + +  L                 G
Sbjct: 46  GASARLSASGSRSPKSGSSETQEAPSAPRPSFPPDAKAKGLLTFHDGGLLQVVGQEVNAG 105

Query: 287 PSASPGSWGESHPQDDFQ--YEDNSDQDDPNQGAFLPAVLHPQVQTQFDQKTQVSALSSG 344
                G    + P        + +S  + P      P  L  +++ +  ++ ++     G
Sbjct: 106 VGVGRGQGTGTRPPAPAAGAADAHSADETPEASGPAPGALVSRLRKRRRRRLRLG-WQPG 164

Query: 345 VSGQLHGDHYYTF-------NIHKPSSHTSLANQGARSEERGARLAESRGRGVTPRASWS 397
           +   + GD   T        + H  S+     +Q A    RG R A    RG   + SW 
Sbjct: 165 LLPHVDGDVVETILEAGRGLSAHGRSTAPRTTDQ-APGLTRGPRPALRCQRGRRLQLSWG 223

Query: 398 RQPAGGPLSSEGH--LLPLVQRDGGGLAEHRGREGEEGVRAGGGGTGEVRGGGSPGRQPV 455
                 P  ++ H  L    +RD      H GR    GV   G G G  R GG  G   V
Sbjct: 224 GGRLVAPSRADTHAALAAFPERD----IFHGGRVVALGVVGEGRGHGGDRRGGGEGLGTV 279

Query: 456 GRAA----VTGEAGAGAAGRGAQSVRGPGVERRVAEGAQQFGPRVGLRQHAERVERAQRA 511
             AA       + GA    RG   ++     R +   AQ    R           R  R 
Sbjct: 280 AAAAPLRVCADDLGAAVGVRGLAGLQEGLDSRHLLHEAQPLHARRRAGHAGSFWLRGGRD 339

Query: 512 AEGRGGGGGGGCGAQAHRRVV----GQGQVRWEGVGQAARGRRMAHHCSQGRNSQSRHQP 567
              RGGG       ++H  VV    G+      G  +  RGRR      QGR  + +  P
Sbjct: 340 RLRRGGG-----HTKSHLGVVTIVPGRRGRAAGGQERGGRGRRR----QQGRRGRRQAGP 390

Query: 568 G 568
           G
Sbjct: 391 G 391



 Score = 31.2 bits (69), Expect = 5.8
 Identities = 46/141 (32%), Positives = 56/141 (39%), Gaps = 29/141 (20%)

Query: 434 VRAGGGGT---GEVRGGGSPGRQPVGRAAVTGEAGAGAAGR--GAQSVRGPGVERRVAEG 488
           V AG  G    G+ RG   P       AA+  EA   AA R  G +  R  G+     EG
Sbjct: 413 VHAGQAGQPLQGQARGPHRP-------AALAQEALRAAAARPHGRRHYRVRGLRGAGPEG 465

Query: 489 AQQF-GPRVGLRQHAERVERAQRA-----------AEGRGGGGGGGCGA-----QAHRRV 531
           A +  GP  GLR     ++ A              A G GG  G G GA      A  R+
Sbjct: 466 AGRLAGPWRGLRLQTLLLQDAPHGGAHEHVLVAVPATGVGGLVGAGQGAVAAAGNAPERL 525

Query: 532 VGQGQVRWEGVGQAARGRRMA 552
               Q   E VG+ ARG R+A
Sbjct: 526 PAGVQGCGEEVGRGARGDRVA 546


>gi|169205732 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 1297

 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 64/208 (30%), Positives = 80/208 (38%), Gaps = 25/208 (12%)

Query: 367  SLANQGARSEERGARLAESRGRGVTPRASWSRQPAGGPLSSEGHLLPLVQRDGGGLAEHR 426
            S+A +GA+    GA L +    GV   A      AGGPL+         +R   G     
Sbjct: 801  SVAAEGAQVAWAGAVLVQGHEAGVAGGARGGGAAAGGPLAGAVVQRMRQRRVRAGRRRVG 860

Query: 427  GR----EGEEGVRAGGGGT----GEVRGGGSPGRQPVGRAAVTGEAGAGAAGRGAQSVRG 478
             R     G +G  AGGGG     G   G     R P  +      A A AA +G ++ +G
Sbjct: 861  ARAVAAAGRQGAGAGGGGRRVRHGHGHGAAVLQRAPCRQQRHLAPAAAAAAAQGVRAAQG 920

Query: 479  PGVERRVAEGAQQFGPRVGLRQHAERVERA---------QRAAEGRGGGGGGGCGAQ-AH 528
                R  A+GA     R G R    R   A          RAA GR  GGG   GA+ AH
Sbjct: 921  -RAHRPGAQGAPSHRHRPGARGRRSRRRAAVALAGGAHPARAALGRRRGGGQAVGARAAH 979

Query: 529  RRVVGQGQV------RWEGVGQAARGRR 550
            +  +  GQV         G     RGRR
Sbjct: 980  QARLAGGQVDQVVVAARAGDADGVRGRR 1007



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 65/217 (29%), Positives = 80/217 (36%), Gaps = 45/217 (20%)

Query: 386 RGRGVTPRASWS--------RQPAGGPLSS-----EGHLLPLVQRDGGGLAEHRGREGEE 432
           RG+GV P A  S        R PA G  +       GH+   V+         RGR  + 
Sbjct: 738 RGQGVGPLAQPSVQVLGRVPRDPAVGAATVAQGPVHGHVP--VELTAAAAVSGRGRLRD- 794

Query: 433 GVRAGGGGTGEVRGGGSPGRQPVGRAAVT---GEAGAGAAGRGAQSVRGPGVERRVAEGA 489
                  G G V    + G Q     AV     EAG     RG  +  G  +   V +  
Sbjct: 795 -------GLGRVASVAAEGAQVAWAGAVLVQGHEAGVAGGARGGGAAAGGPLAGAVVQRM 847

Query: 490 QQFGPRVGLRQHAERVERAQRAAEGRGGGGGGGCGAQAHRRVVGQGQVRWEGVGQAARGR 549
           +Q   R G R    RV     AA GR G G GG G     R V  G      V Q A  R
Sbjct: 848 RQRRVRAGRR----RVGARAVAAAGRQGAGAGGGG-----RRVRHGHGHGAAVLQRAPCR 898

Query: 550 RMAH-------HCSQG-RNSQSR-HQPG-RDRPHHHH 576
           +  H         +QG R +Q R H+PG +  P H H
Sbjct: 899 QQRHLAPAAAAAAAQGVRAAQGRAHRPGAQGAPSHRH 935



 Score = 34.7 bits (78), Expect = 0.52
 Identities = 106/395 (26%), Positives = 132/395 (33%), Gaps = 75/395 (18%)

Query: 208 GQTQARGYEPRTGRDGDPG---TNWDVLQSASGGSLFLGLPSPGHT-RPLP--ARGRREP 261
           G+ + R    R  R   PG    + DVL  A G      L   G   +PL   ARG   P
Sbjct: 373 GRGRRRQQGRRGRRQAGPGLAKVDVDVLAGALGLRWQWVLVHAGQAGQPLQGQARGPHRP 432

Query: 262 EAGESEARPESPPQPQPRRRLARRG-PSASPGSWGE-SHPQDDFQYEDNSDQDDPNQGAF 319
            A   EA   +  +P  RR    RG   A P   G  + P    + +    QD P+ GA 
Sbjct: 433 AALAQEALRAAAARPHGRRHYRVRGLRGAGPEGAGRLAGPWRGLRLQTLLLQDAPHGGAH 492

Query: 320 LPAVLHPQVQTQFDQKTQVSALSSGVSGQLHGDHYYTFNIHKPSSHTSLANQGARSEE-R 378
                         +   V+  ++GV G +                     QG   E  R
Sbjct: 493 --------------EHVLVAVPATGVGGLVGAGQGAVAAAGNAPERLPAGVQGCGEEVGR 538

Query: 379 GAR-----------------LAESRGRGVTPRASWSRQPA--GGPLSSEGHLL------- 412
           GAR                 LA     G    A  +  P   GG L     L+       
Sbjct: 539 GARGDRVAGGHVEVVPVGQQLAICMLHGQLGTAPHAHVPTVLGGALGGRAGLVAAPARRE 598

Query: 413 -PLVQRDGGGLAEHRGREGEEGVRAGGGGTG--EVRG----GGSPGRQPVGRAAVTGEAG 465
            P  +R G      R R G  G   GGGG G  ++ G    GG+ G   V  AA    A 
Sbjct: 599 CPARRRGGCWPRRPRRRHGGGG---GGGGPGLQDLLGGGHAGGAHGHVVVAPAAAAPTAR 655

Query: 466 AGAAGR-GAQSVRGPGVERRVAEGAQ---QFGPRVGLRQHAERVERAQRAAEGRGGGGGG 521
            G AGR G  +V  P V      GA         VG+  H  R   A RA   R    GG
Sbjct: 656 EGRAGRHGHVAVVCPQVAAGAPVGADLDVSVVLWVGVVGHLGRGRGAGRAEAARAAREGG 715

Query: 522 ---------GCGAQAHRRVVGQGQVRWEGVGQAAR 547
                    G G   HR + G    R +GVG  A+
Sbjct: 716 PHQGVFIQRGRGGLGHRPLPGW---RGQGVGPLAQ 747



 Score = 34.3 bits (77), Expect = 0.69
 Identities = 85/361 (23%), Positives = 121/361 (33%), Gaps = 55/361 (15%)

Query: 248 GHTRPLPARGRREPEAGESEA-------RPESPPQPQPRRRLA--------------RRG 286
           G +  L A G R P++G SE        RP  PP  + +  L                 G
Sbjct: 46  GASARLSASGSRSPKSGSSETQEAPSAPRPSFPPDAKAKGLLTFHDGGLLQVVGQEVNAG 105

Query: 287 PSASPGSWGESHPQDDFQ--YEDNSDQDDPNQGAFLPAVLHPQVQTQFDQKTQVSALSSG 344
                G    + P        + +S  + P      P  L  +++ +  ++ ++     G
Sbjct: 106 VGVGRGQGTGTRPPAPAAGAADAHSADETPEASGPAPGALVSRLRKRRRRRLRLG-WQPG 164

Query: 345 VSGQLHGDHYYTF-------NIHKPSSHTSLANQGARSEERGARLAESRGRGVTPRASWS 397
           +   + GD   T        + H  S+     +Q A    RG R A    RG   + SW 
Sbjct: 165 LLPHVDGDVVETILEAGRGLSAHGRSTAPRTTDQ-APGLTRGPRPALRCQRGRRLQLSWG 223

Query: 398 RQPAGGPLSSEGH--LLPLVQRDGGGLAEHRGREGEEGVRAGGGGTGEVRGGGSPGRQPV 455
                 P  ++ H  L    +RD      H GR    GV   G G G  R GG  G   V
Sbjct: 224 GGRLVAPSRADTHAALAAFPERD----IFHGGRVVALGVVGEGRGHGGDRRGGGEGLGTV 279

Query: 456 GRAA----VTGEAGAGAAGRGAQSVRGPGVERRVAEGAQQFGPRVGLRQHAERVERAQRA 511
             AA       + GA    RG   ++     R +   AQ    R           R  R 
Sbjct: 280 AAAAPLRVCADDLGAAVGVRGLAGLQEGLDSRHLLHEAQPLHARRRAGHAGSFWLRGGRD 339

Query: 512 AEGRGGGGGGGCGAQAHRRVV----GQGQVRWEGVGQAARGRRMAHHCSQGRNSQSRHQP 567
              RGGG       ++H  VV    G+      G  +  RGRR      QGR  + +  P
Sbjct: 340 RLRRGGG-----HTKSHLGVVTIVPGRRGRAAGGQERGGRGRRR----QQGRRGRRQAGP 390

Query: 568 G 568
           G
Sbjct: 391 G 391



 Score = 31.2 bits (69), Expect = 5.8
 Identities = 46/141 (32%), Positives = 56/141 (39%), Gaps = 29/141 (20%)

Query: 434 VRAGGGGT---GEVRGGGSPGRQPVGRAAVTGEAGAGAAGR--GAQSVRGPGVERRVAEG 488
           V AG  G    G+ RG   P       AA+  EA   AA R  G +  R  G+     EG
Sbjct: 413 VHAGQAGQPLQGQARGPHRP-------AALAQEALRAAAARPHGRRHYRVRGLRGAGPEG 465

Query: 489 AQQF-GPRVGLRQHAERVERAQRA-----------AEGRGGGGGGGCGA-----QAHRRV 531
           A +  GP  GLR     ++ A              A G GG  G G GA      A  R+
Sbjct: 466 AGRLAGPWRGLRLQTLLLQDAPHGGAHEHVLVAVPATGVGGLVGAGQGAVAAAGNAPERL 525

Query: 532 VGQGQVRWEGVGQAARGRRMA 552
               Q   E VG+ ARG R+A
Sbjct: 526 PAGVQGCGEEVGRGARGDRVA 546


>gi|111118976 collagen, type II, alpha 1 isoform 1 precursor [Homo
            sapiens]
          Length = 1487

 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 111/401 (27%), Positives = 138/401 (34%), Gaps = 79/401 (19%)

Query: 138  GPEGREATRARFPSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQSPEATSNLCRARNEAFR 197
            GPEG        P  +G R  +G +   G   A G +G      P  ++    A  E   
Sbjct: 774  GPEGA-------PGKDGGRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGARGAPGERGE 826

Query: 198  LQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDVLQSASGGSLFLGLPSP----GHTRPL 253
                 P    G   A G     G  G+ G   D    A G     G P P    G T P 
Sbjct: 827  TGPPGPAGFAGPPGADGQPGAKGEQGEAGQKGDA--GAPGPQGPSGAPGPQGPTGVTGPK 884

Query: 254  PARGRREPEAGE-------------SEARPESPPQPQPRRR---LARRGPSASPGSWGES 297
             ARG + P                 S   P  P  P P  +      RG S  PG  GE 
Sbjct: 885  GARGAQGPPGATGFPGAAGRVGPPGSNGNPGPPGPPGPSGKDGPKGARGDSGPPGRAGEP 944

Query: 298  HPQDDF--QYEDNSDQDDPNQGAFLPAVLHPQVQTQFDQKTQVSALSSGVSGQLHGDHYY 355
              Q       E     DD   GA  P    P  Q    Q+  V     G+ GQ  G+  +
Sbjct: 945  GLQGPAGPPGEKGEPGDDGPSGAEGP----PGPQGLAGQRGIV-----GLPGQ-RGERGF 994

Query: 356  TFNIHKPSSHTSLANQGARSEERGARLAESRGRGVTPRASWSRQPAGGPLSSEGHLLPLV 415
               +  PS       QGA                  P AS  R P G P+   G   P  
Sbjct: 995  P-GLPGPSGEPG--KQGA------------------PGASGDRGPPG-PVGPPGLTGPAG 1032

Query: 416  Q--RDGG-GLAEHRGREGEEGVRAGGGGTGEVRGGGSPG-------RQPVGRAAVTGEAG 465
            +  R+G  G     GR+G  GV+   G TG V   G+PG         P G+    GEAG
Sbjct: 1033 EPGREGSPGADGPPGRDGAAGVKGDRGETGAVGAPGAPGPPGSPGPAGPTGKQGDRGEAG 1092

Query: 466  A----GAAG-RGAQSVRGPGVERRVAEGAQQFGPRVGLRQH 501
            A    G +G  GA+ ++GP   R     A + G R GL+ H
Sbjct: 1093 AQGPMGPSGPAGARGIQGPQGPRGDKGEAGEPGER-GLKGH 1132



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 107/415 (25%), Positives = 141/415 (33%), Gaps = 74/415 (17%)

Query: 137 SGPEGREATR--ARFPSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQSPEATSNLCRARNE 194
           +GP+G    R  +    P G     G+  + G   A GL GRP    P+       A  E
Sbjct: 524 AGPKGAPGERGPSGLAGPKGANGDPGRPGEPGLPGARGLTGRPGDAGPQGKVGPSGAPGE 583

Query: 195 AFRLQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDVLQSASGGSLFLGLPSPGHTRPLP 254
             R     PQ   GQ    G+    G +G+PG   +  +   G     GL  PG      
Sbjct: 584 DGRPGPPGPQGARGQPGVMGFPGPKGANGEPGKAGE--KGLPGAPGLRGL--PGKDGETG 639

Query: 255 ARGRREPEAGESEARPESPPQPQPRRRLARRGPSASPGSWGESHPQDDFQYEDNSDQDDP 314
           A G   P     E   +  P P   + L   GP   PG  G+             DQ  P
Sbjct: 640 AAGPPGPAGPAGERGEQGAPGPSGFQGLP--GPPGPPGEGGKP-----------GDQGVP 686

Query: 315 NQGAFLPAVLHPQVQTQFDQKTQVSALSSGVSGQLHGDHYYTFNIHKPSSHTSLANQGAR 374
            + A  P ++ P+ +  F                             P    S   QG +
Sbjct: 687 GE-AGAPGLVGPRGERGF-----------------------------PGERGSPGAQGLQ 716

Query: 375 SEERGARLAESRGRGVTPRASWSRQPAG--GPLSSEGHLLPLVQRDGGGLAEHRGREGEE 432
              RG  L  + G      AS    P G  GP   +G  +P  +R   G+A  +G  G+ 
Sbjct: 717 G-PRG--LPGTPGTDGPKGASGPAGPPGAQGPPGLQG--MP-GERGAAGIAGPKGDRGDV 770

Query: 433 GVRAGGGGTGEVRGGGSPGR-QPVGRAAVTGEAG-------AGAAG-RGAQSVRGPGVER 483
           G +   G  G+  G G  G   P G A   GE G       AG+AG RGA   RG   E 
Sbjct: 771 GEKGPEGAPGKDGGRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGARGAPGERG---ET 827

Query: 484 RVAEGAQQFGPRVGLRQHAERVERAQRAAEGRGG-----GGGGGCGAQAHRRVVG 533
                A   GP     Q   + E+ +   +G  G     G  G  G Q    V G
Sbjct: 828 GPPGPAGFAGPPGADGQPGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTG 882



 Score = 43.9 bits (102), Expect = 9e-04
 Identities = 94/362 (25%), Positives = 118/362 (32%), Gaps = 73/362 (20%)

Query: 144 ATRARFPSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQSPEATSNLCRARNEAFRLQLQRP 203
           AT +  P P G++   G +        +G +G P  Q P                  Q P
Sbjct: 94  ATASGQPGPKGQKGEPGDIKD-----IVGPKGPPGPQGPAGE---------------QGP 133

Query: 204 QRPVGQTQARGYEPRTGRDGDPGTNWDVLQSASGGSLFLGLPSPGHTRPLPARGRREPEA 263
           +   G    +G     GRDG+PGT  +       G    G P  G        G  + +A
Sbjct: 134 RGDRGDKGEKGAPGPRGRDGEPGTPGNPGPPGPPGPP--GPPGLGGNFAAQMAGGFDEKA 191

Query: 264 GESEARPESPPQPQPRRRLARRGPSASPGSWGESHPQDDFQYEDNSDQDDPNQGAFLPAV 323
           G ++      P       +   GP   PG  G   PQ  FQ     +  +P +    P V
Sbjct: 192 GGAQLGVMQGP-------MGPMGPRGPPGPAGAPGPQG-FQ----GNPGEPGE----PGV 235

Query: 324 LHPQVQTQFDQKTQVSALSSGVSGQLHGDHYYTFNIHKPSSHTSLANQGARSEERGARLA 383
             P                 G  G+  GD        K         QGAR       L 
Sbjct: 236 SGPMGPRG----------PPGPPGK-PGDDGEAGKPGKAGERGPPGPQGARGFPGTPGLP 284

Query: 384 ESRGRGVTPRASWSRQPAGGP--------LSSEGHLLPLVQRDGGGLAEHRGREGEEGVR 435
             +G    P    ++  AG P            G   P+  R   GL   RGR G  G  
Sbjct: 285 GVKGHRGYPGLDGAKGEAGAPGVKGESGSPGENGSPGPMGPR---GLPGERGRTGPAGAA 341

Query: 436 AGGGGTGEVRGGGSPGRQPVGRAAVTGEAGA-GAAGR-GAQSVRGPGVERRVAEGAQQFG 493
              G  G+    G PG  PVG A   G  GA GA G  G    RGP       EGAQ  G
Sbjct: 342 GARGNDGQPGPAGPPG--PVGPAGGPGFPGAPGAKGEAGPTGARGP-------EGAQ--G 390

Query: 494 PR 495
           PR
Sbjct: 391 PR 392



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 52/184 (28%), Positives = 67/184 (36%), Gaps = 25/184 (13%)

Query: 137  SGPEGREATRARFPSPNGKRRGSGKLWKRGSFPAIGLEGRP---SLQSPEATSNLCRARN 193
            +G  GRE +      P G+   +G    RG   A+G  G P       P   +     R 
Sbjct: 1031 AGEPGREGSPGA-DGPPGRDGAAGVKGDRGETGAVGAPGAPGPPGSPGPAGPTGKQGDRG 1089

Query: 194  EAFRLQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDV----LQSASGGSLFLGLPSP-- 247
            EA     Q P  P G   ARG +   G  GD G   +     L+   G +   GLP P  
Sbjct: 1090 EA---GAQGPMGPSGPAGARGIQGPQGPRGDKGEAGEPGERGLKGHRGFTGLQGLPGPPG 1146

Query: 248  -----GHTRPLPARGRREP-----EAGESEAR--PESPPQPQPRRRLARRGPSASPGSWG 295
                 G + P    G R P      +G+  A   P     P PR R    GP+  PG+ G
Sbjct: 1147 PSGDQGASGPAGPSGPRGPPGPVGPSGKDGANGIPGPIGPPGPRGRSGETGPAGPPGNPG 1206

Query: 296  ESHP 299
               P
Sbjct: 1207 PPGP 1210



 Score = 36.6 bits (83), Expect = 0.14
 Identities = 120/525 (22%), Positives = 166/525 (31%), Gaps = 81/525 (15%)

Query: 138  GPEGREATRARFPSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQSPEATSNLCRARNEAFR 197
            GP G   T    P  +G +  SG     G+    GL+G P        + +   + +   
Sbjct: 717  GPRGLPGT----PGTDGPKGASGPAGPPGAQGPPGLQGMPG---ERGAAGIAGPKGDRGD 769

Query: 198  LQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDVLQSASGGSLFLGLPSPGHTRPLPARG 257
            +  + P+   G+   RG    TG  G PG        A+G    +G P P  +    A  
Sbjct: 770  VGEKGPEGAPGKDGGRGL---TGPIGPPGP-----AGANGEKGEVGPPGPAGS----AGA 817

Query: 258  RREP-EAGESEARPESPPQPQPRRRLARRGPSASPGSWGESHPQDDFQYEDNSDQDDPNQ 316
            R  P E GE+      PP P         GP  + G  G    Q +   + ++    P  
Sbjct: 818  RGAPGERGET-----GPPGPA-----GFAGPPGADGQPGAKGEQGEAGQKGDAGAPGPQG 867

Query: 317  GAFLPAVLHPQVQT--QFDQKTQVSALSSGVSGQLHGDHYYTFNIHKPSSHTSLANQG-- 372
             +  P    P   T  +  +  Q    ++G  G           +  P S+ +    G  
Sbjct: 868  PSGAPGPQGPTGVTGPKGARGAQGPPGATGFPGAAG-------RVGPPGSNGNPGPPGPP 920

Query: 373  ---ARSEERGARLAESR-GRGVTPRASWSRQPAG--------GPLSSEGHLLPLVQRDGG 420
                +   +GAR      GR   P       P G        GP  +EG   P       
Sbjct: 921  GPSGKDGPKGARGDSGPPGRAGEPGLQGPAGPPGEKGEPGDDGPSGAEGPPGPQGLAGQR 980

Query: 421  GLAEHRGREGEEGVRAGGGGTGEVRGGGSPGRQ-------PVGRAAVTGEAGA------- 466
            G+    G+ GE G     G +GE    G+PG         PVG   +TG AG        
Sbjct: 981  GIVGLPGQRGERGFPGLPGPSGEPGKQGAPGASGDRGPPGPVGPPGLTGPAGEPGREGSP 1040

Query: 467  ---GAAGR-GAQSVRGPGVERRVAEGAQQFGPRVGLRQHAERVERAQRAAEGRGG--GGG 520
               G  GR GA  V+G   E          GP           ++  R   G  G  G  
Sbjct: 1041 GADGPPGRDGAAGVKGDRGETGAVGAPGAPGPPGSPGPAGPTGKQGDRGEAGAQGPMGPS 1100

Query: 521  GGCGAQAHRRVVGQGQVRWEGVGQAARGRRMAHHCSQGRNSQSRHQPGRDRPHHHHLELE 580
            G  GA+  +   G    + E      RG +  H    G        PG   P        
Sbjct: 1101 GPAGARGIQGPQGPRGDKGEAGEPGERGLK-GHRGFTGLQG----LPGPPGPSGDQGASG 1155

Query: 581  SLRERVPCEPPPPLPPLLLGVSLPPFGLPTSASEPDPAQRVQSTG 625
                  P  PP P+ P          G+P     P P  R   TG
Sbjct: 1156 PAGPSGPRGPPGPVGP---SGKDGANGIPGPIGPPGPRGRSGETG 1197



 Score = 36.2 bits (82), Expect = 0.18
 Identities = 102/411 (24%), Positives = 135/411 (32%), Gaps = 68/411 (16%)

Query: 110 PRTP----IKG-TNWTAIHQSRSREGASHGKG-SGPEGREATRARFPSPNGKRRGSGKLW 163
           P TP    +KG   +  +  ++   GA   KG SG  G   +    P P G R   G+  
Sbjct: 278 PGTPGLPGVKGHRGYPGLDGAKGEAGAPGVKGESGSPGENGS----PGPMGPRGLPGERG 333

Query: 164 KRGSFPAIGLEGRPSLQSPEATSNLCRARNEAFRLQLQRPQRPVGQTQARGYEPRTGRDG 223
           + G   A G  G      P                     +   G T ARG E   G  G
Sbjct: 334 RTGPAGAAGARGNDGQPGPAGPPGPVGPAGGPGFPGAPGAKGEAGPTGARGPEGAQGPRG 393

Query: 224 DPGTNWDV-LQSASGGSLFLGLPSPGHTRPLPARGRREPEAGESEARPESPPQPQ-PRRR 281
           +PGT        ASG     G+P    +   P         G     P  PP PQ     
Sbjct: 394 EPGTPGSPGPAGASGNPGTDGIPGAKGSAGAPGIAGAPGFPG-----PRGPPGPQGATGP 448

Query: 282 LARRGPSASPGSWGESHPQDDFQYEDNSDQDDPN----QGAFLPAVLHPQVQTQFDQKTQ 337
           L  +G +  PG  G    Q          + +P     QGA  PA          ++  +
Sbjct: 449 LGPKGQTGEPGIAGFKGEQ--------GPKGEPGPAGPQGAPGPA---------GEEGKR 491

Query: 338 VSALSSGVSGQL--HGDHYYTFNIHKPSSHTSLANQGARSEERGARLAESRG-------- 387
            +    G  G +   G+     N   P        +GA  E   + LA  +G        
Sbjct: 492 GARGEPGGVGPIGPPGERGAPGNRGFPGQDGLAGPKGAPGERGPSGLAGPKGANGDPGRP 551

Query: 388 --------RGVTPRASWSRQ-----PAGGPLSSEGHLLPLVQRDGGGLAEHRGREGEEGV 434
                   RG+T R   +       P+G P   +G   P   +   G     G  G +G 
Sbjct: 552 GEPGLPGARGLTGRPGDAGPQGKVGPSGAP-GEDGRPGPPGPQGARGQPGVMGFPGPKGA 610

Query: 435 RAGGGGTGEVRGGGSPG-RQPVGRAAVTGEAG----AGAAG-RGAQSVRGP 479
               G  GE    G+PG R   G+   TG AG    AG AG RG Q   GP
Sbjct: 611 NGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGPPGPAGPAGERGEQGAPGP 661


>gi|111118974 collagen, type II, alpha 1 isoform 2 precursor [Homo
            sapiens]
          Length = 1418

 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 111/401 (27%), Positives = 138/401 (34%), Gaps = 79/401 (19%)

Query: 138  GPEGREATRARFPSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQSPEATSNLCRARNEAFR 197
            GPEG        P  +G R  +G +   G   A G +G      P  ++    A  E   
Sbjct: 705  GPEGA-------PGKDGGRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGARGAPGERGE 757

Query: 198  LQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDVLQSASGGSLFLGLPSP----GHTRPL 253
                 P    G   A G     G  G+ G   D    A G     G P P    G T P 
Sbjct: 758  TGPPGPAGFAGPPGADGQPGAKGEQGEAGQKGDA--GAPGPQGPSGAPGPQGPTGVTGPK 815

Query: 254  PARGRREPEAGE-------------SEARPESPPQPQPRRR---LARRGPSASPGSWGES 297
             ARG + P                 S   P  P  P P  +      RG S  PG  GE 
Sbjct: 816  GARGAQGPPGATGFPGAAGRVGPPGSNGNPGPPGPPGPSGKDGPKGARGDSGPPGRAGEP 875

Query: 298  HPQDDF--QYEDNSDQDDPNQGAFLPAVLHPQVQTQFDQKTQVSALSSGVSGQLHGDHYY 355
              Q       E     DD   GA  P    P  Q    Q+  V     G+ GQ  G+  +
Sbjct: 876  GLQGPAGPPGEKGEPGDDGPSGAEGP----PGPQGLAGQRGIV-----GLPGQ-RGERGF 925

Query: 356  TFNIHKPSSHTSLANQGARSEERGARLAESRGRGVTPRASWSRQPAGGPLSSEGHLLPLV 415
               +  PS       QGA                  P AS  R P G P+   G   P  
Sbjct: 926  P-GLPGPSGEPG--KQGA------------------PGASGDRGPPG-PVGPPGLTGPAG 963

Query: 416  Q--RDGG-GLAEHRGREGEEGVRAGGGGTGEVRGGGSPG-------RQPVGRAAVTGEAG 465
            +  R+G  G     GR+G  GV+   G TG V   G+PG         P G+    GEAG
Sbjct: 964  EPGREGSPGADGPPGRDGAAGVKGDRGETGAVGAPGAPGPPGSPGPAGPTGKQGDRGEAG 1023

Query: 466  A----GAAG-RGAQSVRGPGVERRVAEGAQQFGPRVGLRQH 501
            A    G +G  GA+ ++GP   R     A + G R GL+ H
Sbjct: 1024 AQGPMGPSGPAGARGIQGPQGPRGDKGEAGEPGER-GLKGH 1063



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 107/415 (25%), Positives = 141/415 (33%), Gaps = 74/415 (17%)

Query: 137 SGPEGREATR--ARFPSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQSPEATSNLCRARNE 194
           +GP+G    R  +    P G     G+  + G   A GL GRP    P+       A  E
Sbjct: 455 AGPKGAPGERGPSGLAGPKGANGDPGRPGEPGLPGARGLTGRPGDAGPQGKVGPSGAPGE 514

Query: 195 AFRLQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDVLQSASGGSLFLGLPSPGHTRPLP 254
             R     PQ   GQ    G+    G +G+PG   +  +   G     GL  PG      
Sbjct: 515 DGRPGPPGPQGARGQPGVMGFPGPKGANGEPGKAGE--KGLPGAPGLRGL--PGKDGETG 570

Query: 255 ARGRREPEAGESEARPESPPQPQPRRRLARRGPSASPGSWGESHPQDDFQYEDNSDQDDP 314
           A G   P     E   +  P P   + L   GP   PG  G+             DQ  P
Sbjct: 571 AAGPPGPAGPAGERGEQGAPGPSGFQGLP--GPPGPPGEGGKP-----------GDQGVP 617

Query: 315 NQGAFLPAVLHPQVQTQFDQKTQVSALSSGVSGQLHGDHYYTFNIHKPSSHTSLANQGAR 374
            + A  P ++ P+ +  F                             P    S   QG +
Sbjct: 618 GE-AGAPGLVGPRGERGF-----------------------------PGERGSPGAQGLQ 647

Query: 375 SEERGARLAESRGRGVTPRASWSRQPAG--GPLSSEGHLLPLVQRDGGGLAEHRGREGEE 432
              RG  L  + G      AS    P G  GP   +G  +P  +R   G+A  +G  G+ 
Sbjct: 648 G-PRG--LPGTPGTDGPKGASGPAGPPGAQGPPGLQG--MP-GERGAAGIAGPKGDRGDV 701

Query: 433 GVRAGGGGTGEVRGGGSPGR-QPVGRAAVTGEAG-------AGAAG-RGAQSVRGPGVER 483
           G +   G  G+  G G  G   P G A   GE G       AG+AG RGA   RG   E 
Sbjct: 702 GEKGPEGAPGKDGGRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGARGAPGERG---ET 758

Query: 484 RVAEGAQQFGPRVGLRQHAERVERAQRAAEGRGG-----GGGGGCGAQAHRRVVG 533
                A   GP     Q   + E+ +   +G  G     G  G  G Q    V G
Sbjct: 759 GPPGPAGFAGPPGADGQPGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTG 813



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 93/358 (25%), Positives = 116/358 (32%), Gaps = 73/358 (20%)

Query: 148 RFPSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQSPEATSNLCRARNEAFRLQLQRPQRPV 207
           R P P G++   G +        +G +G P  Q P                  Q P+   
Sbjct: 29  RQPGPKGQKGEPGDIKD-----IVGPKGPPGPQGPAGE---------------QGPRGDR 68

Query: 208 GQTQARGYEPRTGRDGDPGTNWDVLQSASGGSLFLGLPSPGHTRPLPARGRREPEAGESE 267
           G    +G     GRDG+PGT  +       G    G P  G        G  + +AG ++
Sbjct: 69  GDKGEKGAPGPRGRDGEPGTPGNPGPPGPPGPP--GPPGLGGNFAAQMAGGFDEKAGGAQ 126

Query: 268 ARPESPPQPQPRRRLARRGPSASPGSWGESHPQDDFQYEDNSDQDDPNQGAFLPAVLHPQ 327
                 P       +   GP   PG  G   PQ  FQ     +  +P +    P V  P 
Sbjct: 127 LGVMQGP-------MGPMGPRGPPGPAGAPGPQG-FQ----GNPGEPGE----PGVSGPM 170

Query: 328 VQTQFDQKTQVSALSSGVSGQLHGDHYYTFNIHKPSSHTSLANQGARSEERGARLAESRG 387
                           G  G+  GD        K         QGAR       L   +G
Sbjct: 171 GPRG----------PPGPPGK-PGDDGEAGKPGKAGERGPPGPQGARGFPGTPGLPGVKG 219

Query: 388 RGVTPRASWSRQPAGGP--------LSSEGHLLPLVQRDGGGLAEHRGREGEEGVRAGGG 439
               P    ++  AG P            G   P+  R   GL   RGR G  G     G
Sbjct: 220 HRGYPGLDGAKGEAGAPGVKGESGSPGENGSPGPMGPR---GLPGERGRTGPAGAAGARG 276

Query: 440 GTGEVRGGGSPGRQPVGRAAVTGEAGA-GAAGR-GAQSVRGPGVERRVAEGAQQFGPR 495
             G+    G PG  PVG A   G  GA GA G  G    RGP       EGAQ  GPR
Sbjct: 277 NDGQPGPAGPPG--PVGPAGGPGFPGAPGAKGEAGPTGARGP-------EGAQ--GPR 323



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 52/184 (28%), Positives = 67/184 (36%), Gaps = 25/184 (13%)

Query: 137  SGPEGREATRARFPSPNGKRRGSGKLWKRGSFPAIGLEGRP---SLQSPEATSNLCRARN 193
            +G  GRE +      P G+   +G    RG   A+G  G P       P   +     R 
Sbjct: 962  AGEPGREGSPGA-DGPPGRDGAAGVKGDRGETGAVGAPGAPGPPGSPGPAGPTGKQGDRG 1020

Query: 194  EAFRLQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDV----LQSASGGSLFLGLPSP-- 247
            EA     Q P  P G   ARG +   G  GD G   +     L+   G +   GLP P  
Sbjct: 1021 EA---GAQGPMGPSGPAGARGIQGPQGPRGDKGEAGEPGERGLKGHRGFTGLQGLPGPPG 1077

Query: 248  -----GHTRPLPARGRREP-----EAGESEAR--PESPPQPQPRRRLARRGPSASPGSWG 295
                 G + P    G R P      +G+  A   P     P PR R    GP+  PG+ G
Sbjct: 1078 PSGDQGASGPAGPSGPRGPPGPVGPSGKDGANGIPGPIGPPGPRGRSGETGPAGPPGNPG 1137

Query: 296  ESHP 299
               P
Sbjct: 1138 PPGP 1141



 Score = 36.6 bits (83), Expect = 0.14
 Identities = 120/525 (22%), Positives = 166/525 (31%), Gaps = 81/525 (15%)

Query: 138  GPEGREATRARFPSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQSPEATSNLCRARNEAFR 197
            GP G   T    P  +G +  SG     G+    GL+G P        + +   + +   
Sbjct: 648  GPRGLPGT----PGTDGPKGASGPAGPPGAQGPPGLQGMPG---ERGAAGIAGPKGDRGD 700

Query: 198  LQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDVLQSASGGSLFLGLPSPGHTRPLPARG 257
            +  + P+   G+   RG    TG  G PG        A+G    +G P P  +    A  
Sbjct: 701  VGEKGPEGAPGKDGGRGL---TGPIGPPGP-----AGANGEKGEVGPPGPAGS----AGA 748

Query: 258  RREP-EAGESEARPESPPQPQPRRRLARRGPSASPGSWGESHPQDDFQYEDNSDQDDPNQ 316
            R  P E GE+      PP P         GP  + G  G    Q +   + ++    P  
Sbjct: 749  RGAPGERGET-----GPPGPA-----GFAGPPGADGQPGAKGEQGEAGQKGDAGAPGPQG 798

Query: 317  GAFLPAVLHPQVQT--QFDQKTQVSALSSGVSGQLHGDHYYTFNIHKPSSHTSLANQG-- 372
             +  P    P   T  +  +  Q    ++G  G           +  P S+ +    G  
Sbjct: 799  PSGAPGPQGPTGVTGPKGARGAQGPPGATGFPGAAG-------RVGPPGSNGNPGPPGPP 851

Query: 373  ---ARSEERGARLAESR-GRGVTPRASWSRQPAG--------GPLSSEGHLLPLVQRDGG 420
                +   +GAR      GR   P       P G        GP  +EG   P       
Sbjct: 852  GPSGKDGPKGARGDSGPPGRAGEPGLQGPAGPPGEKGEPGDDGPSGAEGPPGPQGLAGQR 911

Query: 421  GLAEHRGREGEEGVRAGGGGTGEVRGGGSPGRQ-------PVGRAAVTGEAGA------- 466
            G+    G+ GE G     G +GE    G+PG         PVG   +TG AG        
Sbjct: 912  GIVGLPGQRGERGFPGLPGPSGEPGKQGAPGASGDRGPPGPVGPPGLTGPAGEPGREGSP 971

Query: 467  ---GAAGR-GAQSVRGPGVERRVAEGAQQFGPRVGLRQHAERVERAQRAAEGRGG--GGG 520
               G  GR GA  V+G   E          GP           ++  R   G  G  G  
Sbjct: 972  GADGPPGRDGAAGVKGDRGETGAVGAPGAPGPPGSPGPAGPTGKQGDRGEAGAQGPMGPS 1031

Query: 521  GGCGAQAHRRVVGQGQVRWEGVGQAARGRRMAHHCSQGRNSQSRHQPGRDRPHHHHLELE 580
            G  GA+  +   G    + E      RG +  H    G        PG   P        
Sbjct: 1032 GPAGARGIQGPQGPRGDKGEAGEPGERGLK-GHRGFTGLQG----LPGPPGPSGDQGASG 1086

Query: 581  SLRERVPCEPPPPLPPLLLGVSLPPFGLPTSASEPDPAQRVQSTG 625
                  P  PP P+ P          G+P     P P  R   TG
Sbjct: 1087 PAGPSGPRGPPGPVGP---SGKDGANGIPGPIGPPGPRGRSGETG 1128



 Score = 36.2 bits (82), Expect = 0.18
 Identities = 102/411 (24%), Positives = 135/411 (32%), Gaps = 68/411 (16%)

Query: 110 PRTP----IKG-TNWTAIHQSRSREGASHGKG-SGPEGREATRARFPSPNGKRRGSGKLW 163
           P TP    +KG   +  +  ++   GA   KG SG  G   +    P P G R   G+  
Sbjct: 209 PGTPGLPGVKGHRGYPGLDGAKGEAGAPGVKGESGSPGENGS----PGPMGPRGLPGERG 264

Query: 164 KRGSFPAIGLEGRPSLQSPEATSNLCRARNEAFRLQLQRPQRPVGQTQARGYEPRTGRDG 223
           + G   A G  G      P                     +   G T ARG E   G  G
Sbjct: 265 RTGPAGAAGARGNDGQPGPAGPPGPVGPAGGPGFPGAPGAKGEAGPTGARGPEGAQGPRG 324

Query: 224 DPGTNWDV-LQSASGGSLFLGLPSPGHTRPLPARGRREPEAGESEARPESPPQPQ-PRRR 281
           +PGT        ASG     G+P    +   P         G     P  PP PQ     
Sbjct: 325 EPGTPGSPGPAGASGNPGTDGIPGAKGSAGAPGIAGAPGFPG-----PRGPPGPQGATGP 379

Query: 282 LARRGPSASPGSWGESHPQDDFQYEDNSDQDDPN----QGAFLPAVLHPQVQTQFDQKTQ 337
           L  +G +  PG  G    Q          + +P     QGA  PA          ++  +
Sbjct: 380 LGPKGQTGEPGIAGFKGEQ--------GPKGEPGPAGPQGAPGPA---------GEEGKR 422

Query: 338 VSALSSGVSGQL--HGDHYYTFNIHKPSSHTSLANQGARSEERGARLAESRG-------- 387
            +    G  G +   G+     N   P        +GA  E   + LA  +G        
Sbjct: 423 GARGEPGGVGPIGPPGERGAPGNRGFPGQDGLAGPKGAPGERGPSGLAGPKGANGDPGRP 482

Query: 388 --------RGVTPRASWSRQ-----PAGGPLSSEGHLLPLVQRDGGGLAEHRGREGEEGV 434
                   RG+T R   +       P+G P   +G   P   +   G     G  G +G 
Sbjct: 483 GEPGLPGARGLTGRPGDAGPQGKVGPSGAP-GEDGRPGPPGPQGARGQPGVMGFPGPKGA 541

Query: 435 RAGGGGTGEVRGGGSPG-RQPVGRAAVTGEAG----AGAAG-RGAQSVRGP 479
               G  GE    G+PG R   G+   TG AG    AG AG RG Q   GP
Sbjct: 542 NGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGPPGPAGPAGERGEQGAPGP 592


>gi|57864582 hornerin [Homo sapiens]
          Length = 2850

 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 106/478 (22%), Positives = 152/478 (31%), Gaps = 53/478 (11%)

Query: 116  GTNWTAIHQSRSREGASHGKGSGPEGREATRARFPSPNGKRRGSGKLWKRGSFPAIGLEG 175
            G + +A H +  R     G G  P   +       SP+  R GSG     G   + G  G
Sbjct: 868  GQHESASHHASGRGRHGSGSGQSPGHGQRGSGSGQSPSYGRHGSGS----GRSSSSGRHG 923

Query: 176  RPSLQSPEATSNLCRARNEAFRLQLQRPQRPVGQTQARGYEPRTGRDG----------DP 225
              S QS          ++  +       Q   G   +  YE    R G            
Sbjct: 924  SGSGQSSGFGHKSSSGQSSGY------TQHGSGSGHSSSYEQHGSRSGQSSRSEQHGSSS 977

Query: 226  GTNWDVLQSASGGSLFLGLPSPGH---TRPLPARGRREPEAGESEARPESPPQPQPRRRL 282
            G++    Q  SG    LG    G      P P+RGR    +G+S +     P        
Sbjct: 978  GSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSS---YGPYRSGSGWS 1034

Query: 283  ARRGP--SASPGSWGESHPQDDFQYEDNSDQDDPNQGAFLPAVLHPQVQTQFDQKTQVSA 340
            + RGP  S S  S G  H +          Q   + G       H     Q     Q  A
Sbjct: 1035 SSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGA 1094

Query: 341  LSSGVSGQLHGDHYYTFNIHKPSSHTSLANQGARSEERGARLAESRGRGVTPRASWSRQP 400
             SSG S   HG H         S  +    QG+ S +        RG G     S+ R  
Sbjct: 1095 -SSGQSSS-HGQHG-----SGSSQSSGYGRQGSGSGQSPGH--GQRGSGSRQSPSYGRHG 1145

Query: 401  AGGPLSSEGHLLPLVQRDGGGLAEHRGREGE-EGVRAGGGGTGEVRGGGSPGRQPVGRAA 459
            +G   SS          +  G   H    G+       G G+G   G G  G +  G+++
Sbjct: 1146 SGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRS-GQSS 1204

Query: 460  VTGEAGAGAAGRGAQSVRGPGVERRVAEGAQQFGPRVGLRQHAERVERAQRAAEGRGGGG 519
                 G+ +         G G  +    G Q  G      +          ++ G+ G G
Sbjct: 1205 RGERHGSSSGSSSHYGQHGSGSRQSSGHGRQGSGSGHSPSRGRHGSGLGHSSSHGQHGSG 1264

Query: 520  GGGCGAQ-------AHRRVVGQGQVRWEGVGQAA----RGRRMAHHCSQGRNSQSRHQ 566
             G   ++        H  V GQ +    G G ++     G    H CSQG++  +  Q
Sbjct: 1265 SGRSSSRGPYESRSGHSSVFGQHE---SGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQ 1319



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 104/490 (21%), Positives = 162/490 (33%), Gaps = 61/490 (12%)

Query: 123 HQSRSREGASHGKGSGPEGREATRARFPSPNGKRRGSGKLWK-RGSFPAIGLE----GRP 177
           H S SR+ +S+G+        + R +  S +G+  G G+     G  P+ G      GR 
Sbjct: 390 HGSSSRQSSSYGQHESASRHSSGRGQHSSGSGQSPGHGQRGSGSGQSPSSGQHGTGFGRS 449

Query: 178 SLQSPEATSNLCRARNEAFRLQLQRPQRPVGQTQ---ARGYEPRTGRDGD---PGTNWDV 231
           S   P  + +     +  F       +   G TQ     G+    G+ G      +  + 
Sbjct: 450 SSSGPYVSGS---GYSSGFGHHESSSEHSSGYTQHGSGSGHSSGHGQHGSRSGQSSRGER 506

Query: 232 LQSASGGSLFLG------LPSPGHTR--------PLPARGRREPEAGESEARPESPPQPQ 277
             S++G S   G        S GH+R        P P+RGR E  + +S +     P   
Sbjct: 507 QGSSAGSSSSYGQHGSGSRQSLGHSRHGSGSGQSPSPSRGRHESGSRQSSS---YGPHGY 563

Query: 278 PRRRLARRGP--SASPGSWGESHPQDDFQYEDNSDQDDPNQGAFLPAVLHPQVQTQFDQK 335
              R + RGP  S S  S G  H +          Q   + G       H     Q    
Sbjct: 564 GSGRSSSRGPYESGSGHSSGLGHQESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSC 623

Query: 336 TQVSALSSGVSGQLHGDHYYTFNIHKPSSHTSLANQGARSEERGARLAESRGRG-----V 390
            Q  A S   S   HG             H S ++Q +R  ++G+   +S  RG      
Sbjct: 624 GQHGATSGQSSS--HG------------QHGSGSSQSSRYGQQGSGSGQSPSRGRHGSDF 669

Query: 391 TPRASWSRQPAGGPLSSEGHLLPLVQRDGGGLAEHRGREGEEGVRAGGGGTGEVRGGGSP 450
              +S+ +  +G   SS       V     G     G     G    G G+    G    
Sbjct: 670 GHSSSYGQHGSGSGWSSSNGPHGSVSGQSSGFGHKSGSGQSSGYSQHGSGSSHSSGYRKH 729

Query: 451 GRQPVGRAAVTGEAGAGAAGRGAQSVRGPGVERRVAEGAQQFGPRVGLRQHAERVERAQR 510
           G +  G+++ + + G+ +    +    G G  +    G Q  G      +          
Sbjct: 730 GSRS-GQSSRSEQHGSSSGLSSSYGQHGSGSHQSSGHGRQGSGSGHSPSRVRHGSSSGHS 788

Query: 511 AAEGRGGGGGGGCGAQAHRRVVGQGQV-------RWEGVGQAARGRRMAHHCSQGRNSQS 563
           ++ G+  G G  C +       G GQ           G G +  G    H  SQGR+  +
Sbjct: 789 SSHGQ-HGSGTSCSSSCGHYESGSGQASGFGQHESGSGQGYSQHGSASGHFSSQGRHGST 847

Query: 564 RHQPGRDRPH 573
             Q      H
Sbjct: 848 SGQSSSSGQH 857



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 103/458 (22%), Positives = 153/458 (33%), Gaps = 63/458 (13%)

Query: 125  SRSREGASHGKGSGPEGREATRARFPSPNGK-----RRGSGKLWKRGSFPAIGLEGRPSL 179
            S S + + +G+     G+  +R R  S +G      + GSG  W   S    G  G  S 
Sbjct: 1341 SGSSQSSGYGRHGAGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSS----GRHGSGSG 1396

Query: 180  QSPEATSNLCRARNEAFRLQLQR-PQRPVGQTQARGYEPRTGRDGDPGTNWDVLQSASGG 238
            QS           +E+   Q     Q   G   +  YE    R G   +  +   S+SG 
Sbjct: 1397 QSSGF------GHHESSSWQSSGCTQHGSGSGHSSSYEQHGSRSGQ-SSRGERHGSSSGS 1449

Query: 239  SLFLGLPSPGHTRPLPARGRREPEAGESEARPESPPQPQPRRRLARRGPSASPGSWGESH 298
            S   G    G  + L   G+    +G+S       P P   R  +  G S+S   +G   
Sbjct: 1450 SSSYGQHGSGSRQSL-GHGQHGSGSGQS-------PSPSRGRHGSGSGQSSSYSPYGSGS 1501

Query: 299  PQDDFQ--YEDNSDQDDPNQGAFLPAVLHPQVQTQFDQKTQVSALSSGVSGQLHGDHYYT 356
                 +  YE  S             + H + ++           SSG S   HG H  T
Sbjct: 1502 GWSSSRGPYESGSSHSS--------GLGHRESRSGQSSGYGQHGSSSGHSST-HGQHGST 1552

Query: 357  FNIHKP-SSHTSLANQGARSEERGARLAESRGRGVTPRASWSRQPAGGPLSSEGHLLPLV 415
                     H + + Q +   + G+  ++S G G     S  + P  G   S     P  
Sbjct: 1553 SGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGS-GQSPGHGQRGSGSRQSPSY 1611

Query: 416  QRDGGGLAEHRGREGEEGVRAGGGGTGEVRGGGSPGRQPVGRAAVTGEAGAGAAGRGAQS 475
             R G G     GR    G    G G GE  G G              E+ +G +   +Q 
Sbjct: 1612 GRHGSG----SGRSSSSGQH--GSGLGESSGFGHH------------ESSSGQSSSYSQH 1653

Query: 476  VRGPGVERRVAEGAQQFGPRVGLRQHAERVERAQRAAEGRGGGGGGGCGAQAHRRVVGQG 535
              G G     + G  Q G R G     ER   + R++   G  G G   +  H R   QG
Sbjct: 1654 GSGSGH----SSGYGQHGSRSGQSSRGERHGSSSRSSSRYGQHGSGSRQSSGHGR---QG 1706

Query: 536  QVRWEGVGQAARGRRMAHHCSQGRNSQSRHQPGRDRPH 573
                +   +   G  + H  S G++     +     P+
Sbjct: 1707 SGSGQSPSRGRHGSGLGHSSSHGQHGSGSGRSSSRGPY 1744



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 108/470 (22%), Positives = 150/470 (31%), Gaps = 85/470 (18%)

Query: 123  HQSRSREGASHGKGSGPEGREATRARFPSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQSP 182
            H S SR+   HG+     G+       PSP+  R GSG        P     G  S + P
Sbjct: 1456 HGSGSRQSLGHGQHGSGSGQS------PSPSRGRHGSGSGQSSSYSPYGSGSGWSSSRGP 1509

Query: 183  EATSNLCRARNEAFRLQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDVLQS------AS 236
              + +   + +     +  R  +  G  Q       +   G  G+      S      +S
Sbjct: 1510 YESGS---SHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGASS 1566

Query: 237  GGSLFLGLPSPGHTRPLPARGRREPEAGESEARPE----SPPQPQPRRRLARRGPSASPG 292
            G S   G    G ++     GR+   +G+S    +    S   P   R  +  G S+S G
Sbjct: 1567 GQSSSHGQHGSGSSQS-SGYGRQGSGSGQSPGHGQRGSGSRQSPSYGRHGSGSGRSSSSG 1625

Query: 293  SWGESHPQDD-FQYEDNSDQDDPNQGAFLPAVLHPQVQTQFDQKTQVSALSSGVSGQLHG 351
              G    +   F + ++S                           Q S+ S   SG  H 
Sbjct: 1626 QHGSGLGESSGFGHHESS-------------------------SGQSSSYSQHGSGSGHS 1660

Query: 352  DHYYTFNIHKPSSHTSLANQGARSEERGARLAESRGRGVTPRASWSRQPAG-GPLSSEGH 410
              Y          H S + Q +R E  G+    S   G     S SRQ +G G   S   
Sbjct: 1661 SGY--------GQHGSRSGQSSRGERHGSSSRSSSRYG--QHGSGSRQSSGHGRQGSGSG 1710

Query: 411  LLPLVQRDGGGLAEHRGREGEEGVRAGGGGTGEVRGGGSPGRQPVGRAAVTGEAGAGAAG 470
              P   R G GL    G     G    G G    RG   P     G ++V G+  +G+  
Sbjct: 1711 QSPSRGRHGSGL----GHSSSHGQHGSGSGRSSSRG---PYESRSGHSSVFGQHESGSGH 1763

Query: 471  RGAQSVRGPGVERRVAEGAQQFGPRVGLRQ--HAERVERAQRAAEGRGGGG--------- 519
              A S  G G     ++G  Q G   G       E     Q ++ G+ G G         
Sbjct: 1764 SSAYSQHGSGSGHFCSQG--QHGSTSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSSSYGQ 1821

Query: 520  -GGGCGAQAHRRVVGQGQVRWEGVGQAARGRRMAHHCSQGRNSQSRHQPG 568
             G G G    R   G G       GQ   G       S   +S  RH  G
Sbjct: 1822 QGSGSGQSPSRGRHGSGSGHSSSYGQHGSG-------SGWSSSSGRHGSG 1864



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 119/516 (23%), Positives = 167/516 (32%), Gaps = 85/516 (16%)

Query: 123  HQSRSREGASHGKGSGPEGREATRARFPSPNGK-----RRGSGKLWKRGSFPAIGLEGRP 177
            H S S + +S+G+     G+  +R R  S +G      + GSG  W   S    G  G  
Sbjct: 2279 HGSGSSQSSSYGQQGSGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSS----GRHGSG 2334

Query: 178  SLQSPEATSNLCRARNEAFRLQLQRPQRPVGQTQARGYEPRTGRDGDP----------GT 227
            S QS    S      + +++      Q   G   +  YE    R G            G+
Sbjct: 2335 SGQS----SGFGHHESSSWQSS-GYTQHGSGSGHSSSYEQHGSRSGQSSRGERHGSSSGS 2389

Query: 228  NWDVLQSASGGSLFLGLPSPGH---TRPLPARGRREPEAGESEARP--------ESPPQP 276
            +    Q  SG    LG    G      P P+RGR    +G+S +           S   P
Sbjct: 2390 SSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYSPYGSGSGWSSSRGP 2449

Query: 277  QPR---------RRLARRGPSASPGSWGES--HPQDDFQYEDNSDQDDP--NQGAFL-PA 322
                         R +R G S+  G  G S  H     Q+   S Q       GA    +
Sbjct: 2450 YESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGASSGQS 2509

Query: 323  VLHPQVQTQFDQKTQVSALSSGVSGQLHGDHYYTFNIHKPSS---HTSLANQGARSEERG 379
              H Q  +   Q +      SG SGQ  G         +  S   H S + + + S + G
Sbjct: 2510 SSHGQHGSGSSQSSGYGRQGSG-SGQSPGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHG 2568

Query: 380  ARLAESRGRGVTPRASWSRQPAGGPLSSEGHLLPLVQR--------------DGGGLAEH 425
            + L ES G G    +S          S  GH     Q                  G + H
Sbjct: 2569 SGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGERHGSSSGSSSH 2628

Query: 426  RGREGEEGVRAGGGGTGEVRGGGSPGR----QPVGRAAVTGEAGAGAAGRGAQSVRGPGV 481
             G+ G    ++ G G      G SP R      +G ++  G+ G+G+   G  S RGP  
Sbjct: 2629 YGQHGSGSRQSSGHGRQGSGSGQSPSRGRHGSGLGHSSSHGQHGSGS---GRSSSRGP-Y 2684

Query: 482  ERRVAEGAQQFGPRVGLRQHAERVERAQRAAEGRGGGGGGGCGAQAHRRVVGQGQVRWEG 541
            E R+   +  FG       H+        A    G G G  C    H    GQ     + 
Sbjct: 2685 ESRLGH-SSVFGQHESGSGHSS-------AYSQHGSGSGHFCSQGQHGSTSGQSSTFDQE 2736

Query: 542  VGQAARGRRMAHHCSQGRNSQ--SRHQPGRDRPHHH 575
                 +     H  S    S    RH  G  +   H
Sbjct: 2737 GSSTGQSSSYGHRGSGSSQSSGYGRHGAGSGQSLSH 2772



 Score = 47.4 bits (111), Expect = 8e-05
 Identities = 105/493 (21%), Positives = 161/493 (32%), Gaps = 61/493 (12%)

Query: 123  HQSRSREGASHGKGSGPEGREATRARFPSPNGKRRGSGKLWK-RGSFPAIGLEGRPSLQS 181
            H S S + +S G+     G+ ++  +  S + +  G G+     G  P  G  G  S QS
Sbjct: 2019 HGSASGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQS 2078

Query: 182  PEATSNLCRARNEAFRLQLQRPQRP-VGQTQARGYEPRTGRDGDPGTNWDVLQSASGGSL 240
            P    +  R  + + R        P +G++   G+      +   G +    Q  SG   
Sbjct: 2079 P----SYGRHGSGSGRSSSSGQHGPGLGESSGFGHH-----ESSSGQSSSYSQHGSGSGH 2129

Query: 241  FLGLPSPGHTRPLPARGRREPEAGESEAR-----PESPPQPQPRRRLARRGPSASPGSWG 295
              G    G      +RG R   +  S +R       S       R+ +  G S S G  G
Sbjct: 2130 SSGYGQHGSRSGQSSRGERHGSSSGSSSRYGQHGSGSRQSSGHGRQGSGSGHSPSRGRHG 2189

Query: 296  ES--HPQDDFQYEDNSDQDDPNQGAFLPAVLHPQVQTQFDQKTQVSALSSGVSGQLHGDH 353
                H     Q+   S +   ++G +     H  V   F Q    S  SS  S    G  
Sbjct: 2190 SGSGHSSSHGQHGSGSGRSS-SRGPYESRSGHSSV---FGQHESGSGHSSAYSQHGSGSG 2245

Query: 354  YYTFNIHKPSSHTSLANQGARSEERGARLAES-----RGRGVTPRASWSRQPAGGPLS-- 406
            ++         H S + Q +  ++ G+   +S      G G +  +S+ +Q +G   S  
Sbjct: 2246 HFC----SQGQHGSTSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSSSYGQQGSGSGQSPS 2301

Query: 407  ------SEGHLLPLVQR-DGGGLAEHRGREGEEGVRAGGGGTGEVRGGGSPGRQPVGRAA 459
                    GH     Q   G G +   GR G    ++ G G  E     S G    G  +
Sbjct: 2302 RGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGYTQHGSGS 2361

Query: 460  VTGEAGAGAAGRGAQSVRG------PGVERRVAEGAQQFGPRVGLRQHAERVERAQRAAE 513
                +      R  QS RG       G      +        +G  QH     ++   + 
Sbjct: 2362 GHSSSYEQHGSRSGQSSRGERHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSR 2421

Query: 514  GRGGGG----------GGGCGAQAHRRVVGQGQVRWEGVGQAARGRRMAHHCSQGRNSQS 563
            GR G G          G G G  + R     G     G+G   R  R       G++  S
Sbjct: 2422 GRHGSGSGQSSSYSPYGSGSGWSSSRGPYESGSGHSSGLGH--RESRSGQSSGYGQHGSS 2479

Query: 564  RHQPGRDRPHHHH 576
                G    H  H
Sbjct: 2480 ---SGHSSTHGQH 2489



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 103/492 (20%), Positives = 157/492 (31%), Gaps = 59/492 (11%)

Query: 123  HQSRSREGASHGKGSGPEGREATRARFPSPNGKRRGSGKLWK-RGSFPAIGLEGRPSLQS 181
            H S S + +S G+     G+ ++  +  S + +  G G+     G  P  G  G  S QS
Sbjct: 1549 HGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQS 1608

Query: 182  PEATSNLCRARNEAFRLQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDVLQSASGGSLF 241
            P    +   +   +        Q   G  ++ G+       G   +     Q  SG    
Sbjct: 1609 PSYGRHGSGSGRSS-----SSGQHGSGLGESSGFGHHESSSGQSSS---YSQHGSGSGHS 1660

Query: 242  LGLPSPGHTRPLPARGRREPEAGESEAR-----PESPPQPQPRRRLARRGPSASPGSWGE 296
             G    G      +RG R   +  S +R       S       R+ +  G S S G  G 
Sbjct: 1661 SGYGQHGSRSGQSSRGERHGSSSRSSSRYGQHGSGSRQSSGHGRQGSGSGQSPSRGRHGS 1720

Query: 297  S--HPQDDFQYEDNSDQDDPNQGAFLPAVLHPQVQTQFDQKTQVSALSSGVSGQLHGDHY 354
               H     Q+   S +   ++G +     H  V   F Q    S  SS  S    G  +
Sbjct: 1721 GLGHSSSHGQHGSGSGRSS-SRGPYESRSGHSSV---FGQHESGSGHSSAYSQHGSGSGH 1776

Query: 355  YTFNIHKPSSHTSLANQGARSEERGARLAES-----RGRGVTPRASWSRQPAGGPLS--- 406
            +         H S + Q +  ++ G+   +S      G G +  +S+ +Q +G   S   
Sbjct: 1777 FC----SQGQHGSTSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSSSYGQQGSGSGQSPSR 1832

Query: 407  -----SEGHLLPLVQR-DGGGLAEHRGREGEEGVRAGGGGTGEVRGGGSPGRQPVGRAAV 460
                   GH     Q   G G +   GR G    ++ G G  E     S G    G  + 
Sbjct: 1833 GRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGYTQHGSGSG 1892

Query: 461  TGEAGAGAAGRGAQSVRG------PGVERRVAEGAQQFGPRVGLRQHAERVERAQRAAEG 514
               +      R  QS RG       G      +        +G  QH     ++   + G
Sbjct: 1893 HSSSYEQHGSRSGQSSRGEQHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRG 1952

Query: 515  RGGGG----------GGGCGAQAHRRVVGQGQVRWEGVGQAARGRRMAHHCSQGRNSQSR 564
            R G G          G G G  + R     G     G+G   R  R       G++  S 
Sbjct: 1953 RHGSGSGQSSSYGPYGSGSGWSSSRGPYESGSGHSSGLGH--RESRSGQSSGYGQHGSS- 2009

Query: 565  HQPGRDRPHHHH 576
               G    H  H
Sbjct: 2010 --SGHSSTHGQH 2019



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 113/491 (23%), Positives = 163/491 (33%), Gaps = 68/491 (13%)

Query: 123  HQSRSREGASHGKGSGPEGREATRARFPSPNGKRRGSGKLWKR-GSFPAIGLEGRPSLQ- 180
            H+S SR+ +S+G      GR ++R  + S +G   G G    R G     G  G  S   
Sbjct: 548  HESGSRQSSSYGPHGYGSGRSSSRGPYESGSGHSSGLGHQESRSGQSSGYGQHGSSSGHS 607

Query: 181  -------SPEATSNLCRARNEAFRLQLQRPQRPVGQTQA---------RGYEPRTGRDGD 224
                   S    S+ C              Q   G +Q+          G  P  GR G 
Sbjct: 608  STHGQHGSTSGQSSSCGQHGATSGQSSSHGQHGSGSSQSSRYGQQGSGSGQSPSRGRHGS 667

Query: 225  ------------PGTNWDVLQ----SASGGSLFLGLPS-PGHTRPLPARGR-REPEAGES 266
                         G+ W        S SG S   G  S  G +      G      +G  
Sbjct: 668  DFGHSSSYGQHGSGSGWSSSNGPHGSVSGQSSGFGHKSGSGQSSGYSQHGSGSSHSSGYR 727

Query: 267  EARPESPPQPQPRRRLARRGPSASPGSWGE-SHPQDDFQYEDNSDQDDPNQGAFLPAVLH 325
            +    S    +  +  +  G S+S G  G  SH       + +     P++     +  H
Sbjct: 728  KHGSRSGQSSRSEQHGSSSGLSSSYGQHGSGSHQSSGHGRQGSGSGHSPSRVRHGSSSGH 787

Query: 326  PQVQTQFDQKTQVSA----LSSGVSGQLHGDHYYTFNIHKPSSHTSLANQGARSEERGAR 381
                 Q    T  S+      SG SGQ  G     F  H+  S    +  G+ S   G  
Sbjct: 788  SSSHGQHGSGTSCSSSCGHYESG-SGQASG-----FGQHESGSGQGYSQHGSAS---GHF 838

Query: 382  LAESRGRGVTPRASWSRQ--PAGGPLSSEGHLLPLVQRDGGGLAEHRGREGEEGVRAGGG 439
             ++ R    + ++S S Q   + G  SS G             A  RGR G    ++ G 
Sbjct: 839  SSQGRHGSTSGQSSSSGQHDSSSGQSSSYGQ-----HESASHHASGRGRHGSGSGQSPGH 893

Query: 440  GTGEVRGGGSP--GRQPVGRAAVTGEAGAGAAGRGAQSVRGPGVERRVAEGAQQFGPRVG 497
            G      G SP  GR   G +  +  +G   +G G  S  G       + G  Q G   G
Sbjct: 894  GQRGSGSGQSPSYGRHGSG-SGRSSSSGRHGSGSGQSSGFGHKSSSGQSSGYTQHGSGSG 952

Query: 498  ----LRQHAERVERAQRAAE-GRGGGGGGGCG--AQAHRRVVGQGQVRWEGVGQAARGRR 550
                  QH  R  ++ R+ + G   G     G      R+ +G GQ    G GQ+    R
Sbjct: 953  HSSSYEQHGSRSGQSSRSEQHGSSSGSSSSYGQHGSGSRQSLGHGQ-HGSGSGQSPSPSR 1011

Query: 551  MAHHCSQGRNS 561
              H    G++S
Sbjct: 1012 GRHGSGSGQSS 1022



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 125/544 (22%), Positives = 175/544 (32%), Gaps = 131/544 (24%)

Query: 123 HQSRSREGAS---HGKGSGPE---GREATRARFPSPNGKRRGSGKLWKRGSFPAIGLEGR 176
           H+S S   +    HG GSG     G+  +R+   S  G+R+GS      GS  + G  G 
Sbjct: 468 HESSSEHSSGYTQHGSGSGHSSGHGQHGSRSG-QSSRGERQGSSA----GSSSSYGQHGS 522

Query: 177 PSLQSPEATSNLCRARNEAFRLQLQRPQR---PVGQTQARGYEPR---TGRDGDPGTNWD 230
            S QS      L  +R+ +   Q   P R     G  Q+  Y P    +GR    G    
Sbjct: 523 GSRQS------LGHSRHGSGSGQSPSPSRGRHESGSRQSSSYGPHGYGSGRSSSRGP--- 573

Query: 231 VLQSASGGSLFLGLP---------------SPGHTRPLPARGRREPEA----------GE 265
             +S SG S  LG                 S GH+      G    ++          G+
Sbjct: 574 -YESGSGHSSGLGHQESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGATSGQ 632

Query: 266 SEARPESPPQPQPRRRLARRGPSASPGSWGESHPQDDFQYEDNSDQDDPNQGAFLPAVLH 325
           S +  +         R  ++G S S  S        DF +  +  Q     G       H
Sbjct: 633 SSSHGQHGSGSSQSSRYGQQG-SGSGQSPSRGRHGSDFGHSSSYGQHGSGSGWSSSNGPH 691

Query: 326 PQVQTQ---FDQKT---QVSALSSGVSGQLHGDHYYTFNIHKPSSHTSLANQGARSEERG 379
             V  Q   F  K+   Q S  S   SG  H   Y          H S + Q +RSE+ G
Sbjct: 692 GSVSGQSSGFGHKSGSGQSSGYSQHGSGSSHSSGY--------RKHGSRSGQSSRSEQHG 743

Query: 380 ARLAES-----RGRGVTPRASWSRQPAGGPLS--------SEGHLLPLVQRDGG------ 420
           +    S      G G    +   RQ +G   S        S GH     Q   G      
Sbjct: 744 SSSGLSSSYGQHGSGSHQSSGHGRQGSGSGHSPSRVRHGSSSGHSSSHGQHGSGTSCSSS 803

Query: 421 ------------GLAEHRGREGEEGVRAGGGGTGEVRGGGSPGRQPVGRAAVTGE----- 463
                       G  +H    G+ G    G  +G     G  G    G+++ +G+     
Sbjct: 804 CGHYESGSGQASGFGQHESGSGQ-GYSQHGSASGHFSSQGRHGSTS-GQSSSSGQHDSSS 861

Query: 464 -----------AGAGAAGRGAQ---SVRGPGVERRVAEGAQQFGPRVGLRQHAERVERAQ 509
                      A   A+GRG     S + PG  +R +   Q   P  G  +H     R+ 
Sbjct: 862 GQSSSYGQHESASHHASGRGRHGSGSGQSPGHGQRGSGSGQS--PSYG--RHGSGSGRS- 916

Query: 510 RAAEGRGGGGGGGCGAQAHRRVVGQGQVRWEGVGQAARGRRMAHHCSQGRNSQSRHQPGR 569
            ++ GR G G G      H+   GQ        G    G    H  S  ++     Q  R
Sbjct: 917 -SSSGRHGSGSGQSSGFGHKSSSGQSS------GYTQHGSGSGHSSSYEQHGSRSGQSSR 969

Query: 570 DRPH 573
              H
Sbjct: 970 SEQH 973



 Score = 39.7 bits (91), Expect = 0.016
 Identities = 115/517 (22%), Positives = 162/517 (31%), Gaps = 89/517 (17%)

Query: 123  HQSRSREGASHGKGSGPEGREATRARFPSPNGKRR-------GSGKLWKRGSFPAIGLEG 175
            H S SR+ + HG+     G+  +R R  S  G          GSG+   RG + +    G
Sbjct: 1692 HGSGSRQSSGHGRQGSGSGQSPSRGRHGSGLGHSSSHGQHGSGSGRSSSRGPYES--RSG 1749

Query: 176  RPSL----QSPEATSNLCRARNEAFRLQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDV 231
              S+    +S    S+              + Q      Q+  ++      G   ++   
Sbjct: 1750 HSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSHG-- 1807

Query: 232  LQSASGGSLFLGLPSPGH-TRPLPARGRREPEAGESEARPESPPQPQPRRRLARRGPSAS 290
             Q  SG S        G  +   P+RGR    +G S +  +            R G S S
Sbjct: 1808 -QHGSGSSQSSSYGQQGSGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHG-SGS 1865

Query: 291  PGSWGESHPQDDFQYEDNSDQDDPNQGAFLPAVLHPQVQTQFDQKTQVSALSSGVSGQLH 350
              S G  H +          Q     G            + ++Q    S  SS   G+ H
Sbjct: 1866 GQSSGFGHHESSSWQSSGYTQHGSGSGH----------SSSYEQHGSRSGQSS--RGEQH 1913

Query: 351  GDHY---YTFNIHKPSSHTSLANQGARSEERGARLAESRGR-GVTPRASWSRQPAG---- 402
            G       ++  H   S  SL + G      G   + SRGR G     S S  P G    
Sbjct: 1914 GSSSGSSSSYGQHGSGSRQSLGH-GQHGSGSGQSPSPSRGRHGSGSGQSSSYGPYGSGSG 1972

Query: 403  -----GPLSS-EGHLLPLVQRDG-----GGLAEHRGREG-------------------EE 432
                 GP  S  GH   L  R+       G  +H    G                   + 
Sbjct: 1973 WSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSASGQSSSCGQH 2032

Query: 433  GVRAGGGGTGEVRGGGSP-----GRQPVGRAAVTGEAGAGAAGRGAQSVRGPGVERRVAE 487
            G  +G   +    G GS      GRQ  G     G    G+  R + S    G     + 
Sbjct: 2033 GASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQSPSYGRHGSGSGRSS 2092

Query: 488  GAQQFGPRVGLRQ---HAERVERAQRAAEGRGGGGGGGCGAQAHRRVVGQ---GQVRWEG 541
             + Q GP +G      H E       +    G G G   G   H    GQ   G+     
Sbjct: 2093 SSGQHGPGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGERHGSS 2152

Query: 542  VGQAAR-------GRRMAHHCSQGRNSQSRHQPGRDR 571
             G ++R        R+ + H  QG  S S H P R R
Sbjct: 2153 SGSSSRYGQHGSGSRQSSGHGRQG--SGSGHSPSRGR 2187



 Score = 38.1 bits (87), Expect = 0.047
 Identities = 103/477 (21%), Positives = 160/477 (33%), Gaps = 46/477 (9%)

Query: 123 HQSRSREGASHGKGSGPEGREATRARFPSPNGK-----RRGSGKL-------WKRGSFPA 170
           H S SR+   HG+      +  +  R  S +G      + GSG         ++ GS   
Sbjct: 286 HGSGSRQSLGHGRQGSGSRQSPSHVRHGSGSGHSSSHGQHGSGSSYSYSRGHYESGSGQT 345

Query: 171 IGLEGRPSLQSPEATSNLCRARNEAFRLQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWD 230
            G  G+    S +++                +     GQ  + G    + R     +++ 
Sbjct: 346 SGF-GQHESGSGQSSGYSKHGSGSGHSSSQGQHGSTSGQASSSGQHGSSSRQ---SSSYG 401

Query: 231 VLQSASGGSLFLGLPSPGHTRPLPARGRREPEAGESEARPESPPQPQPRRRLARRGP--S 288
             +SAS  S   G  S G  +  P  G+R   +G+S   P S        R +  GP  S
Sbjct: 402 QHESASRHSSGRGQHSSGSGQS-PGHGQRGSGSGQS---PSSGQHGTGFGRSSSSGPYVS 457

Query: 289 ASPGSWGESHPQDDFQYEDNSDQDDPNQGAFLPAVLH--PQVQTQFDQKTQVSALSSGVS 346
            S  S G  H +   ++     Q     G       H     Q+   ++   SA SS   
Sbjct: 458 GSGYSSGFGHHESSSEHSSGYTQHGSGSGHSSGHGQHGSRSGQSSRGERQGSSAGSSSSY 517

Query: 347 GQLHGDHYYTFNIHKPSSHTSLANQGARS-EERGARLAESRG-RGVTPRASWSRQPAGGP 404
           GQ       +    +  S +  +   +R   E G+R + S G  G     S SR P    
Sbjct: 518 GQHGSGSRQSLGHSRHGSGSGQSPSPSRGRHESGSRQSSSYGPHGYGSGRSSSRGPYE-- 575

Query: 405 LSSEGHLLPLVQRDGGGLAEHRGREGE-EGVRAGGGGTGEVRGGGSPGRQPVGRAAVTGE 463
            S  GH          GL     R G+  G    G  +G     G  G    G+++  G+
Sbjct: 576 -SGSGH--------SSGLGHQESRSGQSSGYGQHGSSSGHSSTHGQHG-STSGQSSSCGQ 625

Query: 464 AGAGAAGRGAQSVRGPGVERRVAEGAQQFGPRVGLRQHAERVERAQRAAEGRGGGGGGGC 523
            GA +    +    G G  +    G Q  G      +     +    ++ G+ G G G  
Sbjct: 626 HGATSGQSSSHGQHGSGSSQSSRYGQQGSGSGQSPSRGRHGSDFGHSSSYGQHGSGSGWS 685

Query: 524 GAQA-HRRVVGQ--GQVRWEGVGQAA----RGRRMAHHCSQGRNSQSRHQPGRDRPH 573
            +   H  V GQ  G     G GQ++     G   +H     ++     Q  R   H
Sbjct: 686 SSNGPHGSVSGQSSGFGHKSGSGQSSGYSQHGSGSSHSSGYRKHGSRSGQSSRSEQH 742



 Score = 35.8 bits (81), Expect = 0.24
 Identities = 120/518 (23%), Positives = 174/518 (33%), Gaps = 105/518 (20%)

Query: 123  HQSRSREGASHGKGSGPEGREATRARFPSPNGK-----RRGSGKL-------WKRGSFPA 170
            H S S + + HG+     G   +R R  S +G      + GSG         ++ GS  A
Sbjct: 755  HGSGSHQSSGHGRQGSGSGHSPSRVRHGSSSGHSSSHGQHGSGTSCSSSCGHYESGSGQA 814

Query: 171  IGLEGRPSLQSPEATSNLCRARNEAFRLQLQRPQRPVGQTQARG-YEPRTGRDGDPGTNW 229
             G  G+    S +  S    A    F  Q  R     GQ+ + G ++  +G+    G + 
Sbjct: 815  SGF-GQHESGSGQGYSQHGSASGH-FSSQ-GRHGSTSGQSSSSGQHDSSSGQSSSYGQHE 871

Query: 230  DVLQSASG-GSLFLGL-PSPGHTRPLPARGRREPEAGESEARPESPPQPQPRRRLARRGP 287
                 ASG G    G   SPGH       G+R   +G+S         P   R  +  G 
Sbjct: 872  SASHHASGRGRHGSGSGQSPGH-------GQRGSGSGQS---------PSYGRHGSGSGR 915

Query: 288  SASPGSWGESHPQDD-FQYEDNSDQDDPNQGAFLPAVLHPQVQTQFDQKTQVSALSSGVS 346
            S+S G  G    Q   F ++ +S Q       +          + ++Q    S  SS   
Sbjct: 916  SSSSGRHGSGSGQSSGFGHKSSSGQSS----GYTQHGSGSGHSSSYEQHGSRSGQSS--R 969

Query: 347  GQLHGDHY---YTFNIHKPSSHTSLANQGARSEERGARLAESRGR---GVTPRASWSRQP 400
             + HG       ++  H   S  SL + G      G   + SRGR   G    +S+    
Sbjct: 970  SEQHGSSSGSSSSYGQHGSGSRQSLGH-GQHGSGSGQSPSPSRGRHGSGSGQSSSYGPYR 1028

Query: 401  AG-------GPLSS-EGHLLPLVQRDG-----GGLAEHRGREG----------------- 430
            +G       GP  S  GH   L  R+       G  +H    G                 
Sbjct: 1029 SGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSS 1088

Query: 431  --EEGVRAGGGGTGEVRGGGSP-----GRQPVGRAAVTGEAGAGAAGRGAQSV--RGPGV 481
              + G  +G   +    G GS      GRQ  G     G    G+  R + S    G G 
Sbjct: 1089 CGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQSPSYGRHGSGS 1148

Query: 482  ERRVAEG--AQQFGPRVGLRQH-AERVERAQRAAEGRGGGGGGGCGAQAHRRVVGQGQVR 538
             R  + G      G   G   H +   + +  +  G G G   G G    R         
Sbjct: 1149 GRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRS-------- 1200

Query: 539  WEGVGQAARGRRMAHHCSQGRNSQ-SRHQPGRDRPHHH 575
                GQ++RG R  H  S G +S   +H  G  +   H
Sbjct: 1201 ----GQSSRGER--HGSSSGSSSHYGQHGSGSRQSSGH 1232



 Score = 34.7 bits (78), Expect = 0.52
 Identities = 78/359 (21%), Positives = 123/359 (34%), Gaps = 65/359 (18%)

Query: 123  HQSRSREGASHGKGSGPEGREATRARFPSPNGKRRGSGKLWKRGS----FPAIGLEGRPS 178
            H + S + +SHG+      + +   R  S +G+  G G   +RGS     P+ G  G  S
Sbjct: 2502 HGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHG---QRGSGSRQSPSYGRHGSGS 2558

Query: 179  LQSPEA--------TSNLCRARNEAFRLQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWD 230
             +S  +         S+       +        Q   G   + GY     R G   +  +
Sbjct: 2559 GRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQ-SSRGE 2617

Query: 231  VLQSASGGSLFLGLPSPGHTRPLPARGRREPEAGESEARPESPPQPQPRRRLARRGPSAS 290
               S+SG S   G    G +R     GR+   +G+S         P   R  +  G S+S
Sbjct: 2618 RHGSSSGSSSHYGQHGSG-SRQSSGHGRQGSGSGQS---------PSRGRHGSGLGHSSS 2667

Query: 291  PGSWGESHPQDDFQYEDNSDQDDPNQGAFLPAVLHPQVQTQFDQKTQVSALSSGVSGQLH 350
             G  G    +              ++G +   + H  V   F Q    S  SS  S    
Sbjct: 2668 HGQHGSGSGRSS------------SRGPYESRLGHSSV---FGQHESGSGHSSAYSQHGS 2712

Query: 351  GDHYYTFNIHKPSSHTSLANQGARSEERGARLAES-----RGRGVTPRASWSRQPAGGPL 405
            G  ++         H S + Q +  ++ G+   +S     RG G +  + + R  AG   
Sbjct: 2713 GSGHFC----SQGQHGSTSGQSSTFDQEGSSTGQSSSYGHRGSGSSQSSGYGRHGAGSGQ 2768

Query: 406  --------SSEGHLLPLVQRDGG-----GLAEHRGREGEEGVRAGGGGTGEVRGGGSPG 451
                    S  G      Q   G     G ++H    G++G     GG+     GGS G
Sbjct: 2769 SLSHGRHGSGSGQSSSYGQHGSGSGQSSGYSQHGSGSGQDGYSYCKGGSN--HDGGSSG 2825


>gi|40068464 AT rich interactive domain 1B (SWI1-like) isoform 2
           [Homo sapiens]
          Length = 2191

 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 83/352 (23%), Positives = 116/352 (32%), Gaps = 60/352 (17%)

Query: 198 LQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDVLQSASGGSLFLGLPSPGHTRPLPARG 257
           LQ Q  Q    Q Q +  + +  +   P +N + L  A GG+     P PG     P  G
Sbjct: 48  LQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGA-----PQPGPDMEQPQHG 102

Query: 258 RREPEAGESEARPESPPQPQPRRRLARRGPSASPGSWGESHPQDDFQYEDNSDQDDPNQG 317
             +  A   +A P  PP              + PG   ++ P+            +P  G
Sbjct: 103 GAKDSAAGGQADPPGPPL------------LSKPGDEDDAPPK----------MGEPAGG 140

Query: 318 AFLPAVLHPQVQTQFDQKTQVSALSSGVSGQLHGDHYYTFNIHKPSSHTSLANQGARSEE 377
            +     HP +     Q+  V+    G       +    +    P+S       G   ++
Sbjct: 141 RY----EHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQ 196

Query: 378 RGARLAESRGRGVTPRASWSRQPAGGPL-----------SSEGHLLPLVQRDGGGLAEHR 426
            G +  +S G G+   AS +   A G +           +S+ +  P   R G G     
Sbjct: 197 HGGQ--QSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGG 254

Query: 427 GREGEEGVRAGGGGTGEVRGGGSPGRQPVGRAAVTGEAGAGAAGRGAQSVRGPGV--ERR 484
           G  G  G   GGGG G   GG   G      AA    AG G  G    S  G GV    R
Sbjct: 255 GGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPR 314

Query: 485 VAEGAQQFGPRVGLRQHAERVERAQRAAEGRGGGGGGGCGAQAHRRVVGQGQ 536
              G    GP  G            +AA G   GG         +R  GQ Q
Sbjct: 315 QQGGGMMMGPGGG------GAASLSKAAAGSAAGG--------FQRFAGQNQ 352



 Score = 38.9 bits (89), Expect = 0.028
 Identities = 58/216 (26%), Positives = 74/216 (34%), Gaps = 37/216 (17%)

Query: 360 HKPSSHTSLANQGARSEERGARLAESRGRGVTPRASWSR-QPAGGPLSS----EGHLLPL 414
           H  S++ SL   G  + + G  + + +  G    A+  +  P G PL S    E    P 
Sbjct: 74  HPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPK 133

Query: 415 VQRDGGGLAEHRG------REGEEGVRAGGGGTGEVR------GGGSPGRQPVGRAAVTG 462
           +    GG  EH G      ++    V  GGGG   V       G  +P     G     G
Sbjct: 134 MGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPG-----G 188

Query: 463 EAGAGAAGRGAQSVRGPGVERRV-AEGAQQFGPRVGLRQHAERVERAQ---------RAA 512
            AG      G Q   G G+     A  A   G    L+   E    +Q           A
Sbjct: 189 RAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGA 248

Query: 513 EGRGGGGGGGCGAQAHRRVVGQGQVRWEGVGQAARG 548
            G GGGGGGG G        G G     G G A  G
Sbjct: 249 GGGGGGGGGGGGGSG-----GGGGGGGAGAGGAGAG 279


>gi|40068466 AT rich interactive domain 1B (SWI1-like) isoform 1
           [Homo sapiens]
          Length = 2231

 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 83/352 (23%), Positives = 116/352 (32%), Gaps = 60/352 (17%)

Query: 198 LQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDVLQSASGGSLFLGLPSPGHTRPLPARG 257
           LQ Q  Q    Q Q +  + +  +   P +N + L  A GG+     P PG     P  G
Sbjct: 48  LQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGA-----PQPGPDMEQPQHG 102

Query: 258 RREPEAGESEARPESPPQPQPRRRLARRGPSASPGSWGESHPQDDFQYEDNSDQDDPNQG 317
             +  A   +A P  PP              + PG   ++ P+            +P  G
Sbjct: 103 GAKDSAAGGQADPPGPPL------------LSKPGDEDDAPPK----------MGEPAGG 140

Query: 318 AFLPAVLHPQVQTQFDQKTQVSALSSGVSGQLHGDHYYTFNIHKPSSHTSLANQGARSEE 377
            +     HP +     Q+  V+    G       +    +    P+S       G   ++
Sbjct: 141 RY----EHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQ 196

Query: 378 RGARLAESRGRGVTPRASWSRQPAGGPL-----------SSEGHLLPLVQRDGGGLAEHR 426
            G +  +S G G+   AS +   A G +           +S+ +  P   R G G     
Sbjct: 197 HGGQ--QSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGG 254

Query: 427 GREGEEGVRAGGGGTGEVRGGGSPGRQPVGRAAVTGEAGAGAAGRGAQSVRGPGV--ERR 484
           G  G  G   GGGG G   GG   G      AA    AG G  G    S  G GV    R
Sbjct: 255 GGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPR 314

Query: 485 VAEGAQQFGPRVGLRQHAERVERAQRAAEGRGGGGGGGCGAQAHRRVVGQGQ 536
              G    GP  G            +AA G   GG         +R  GQ Q
Sbjct: 315 QQGGGMMMGPGGG------GAASLSKAAAGSAAGG--------FQRFAGQNQ 352



 Score = 38.9 bits (89), Expect = 0.028
 Identities = 58/216 (26%), Positives = 74/216 (34%), Gaps = 37/216 (17%)

Query: 360 HKPSSHTSLANQGARSEERGARLAESRGRGVTPRASWSR-QPAGGPLSS----EGHLLPL 414
           H  S++ SL   G  + + G  + + +  G    A+  +  P G PL S    E    P 
Sbjct: 74  HPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPK 133

Query: 415 VQRDGGGLAEHRG------REGEEGVRAGGGGTGEVR------GGGSPGRQPVGRAAVTG 462
           +    GG  EH G      ++    V  GGGG   V       G  +P     G     G
Sbjct: 134 MGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPG-----G 188

Query: 463 EAGAGAAGRGAQSVRGPGVERRV-AEGAQQFGPRVGLRQHAERVERAQ---------RAA 512
            AG      G Q   G G+     A  A   G    L+   E    +Q           A
Sbjct: 189 RAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGA 248

Query: 513 EGRGGGGGGGCGAQAHRRVVGQGQVRWEGVGQAARG 548
            G GGGGGGG G        G G     G G A  G
Sbjct: 249 GGGGGGGGGGGGGSG-----GGGGGGGAGAGGAGAG 279


>gi|40068462 AT rich interactive domain 1B (SWI1-like) isoform 3
           [Homo sapiens]
          Length = 2178

 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 83/352 (23%), Positives = 116/352 (32%), Gaps = 60/352 (17%)

Query: 198 LQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDVLQSASGGSLFLGLPSPGHTRPLPARG 257
           LQ Q  Q    Q Q +  + +  +   P +N + L  A GG+     P PG     P  G
Sbjct: 48  LQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGA-----PQPGPDMEQPQHG 102

Query: 258 RREPEAGESEARPESPPQPQPRRRLARRGPSASPGSWGESHPQDDFQYEDNSDQDDPNQG 317
             +  A   +A P  PP              + PG   ++ P+            +P  G
Sbjct: 103 GAKDSAAGGQADPPGPPL------------LSKPGDEDDAPPK----------MGEPAGG 140

Query: 318 AFLPAVLHPQVQTQFDQKTQVSALSSGVSGQLHGDHYYTFNIHKPSSHTSLANQGARSEE 377
            +     HP +     Q+  V+    G       +    +    P+S       G   ++
Sbjct: 141 RY----EHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQ 196

Query: 378 RGARLAESRGRGVTPRASWSRQPAGGPL-----------SSEGHLLPLVQRDGGGLAEHR 426
            G +  +S G G+   AS +   A G +           +S+ +  P   R G G     
Sbjct: 197 HGGQ--QSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGG 254

Query: 427 GREGEEGVRAGGGGTGEVRGGGSPGRQPVGRAAVTGEAGAGAAGRGAQSVRGPGV--ERR 484
           G  G  G   GGGG G   GG   G      AA    AG G  G    S  G GV    R
Sbjct: 255 GGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPR 314

Query: 485 VAEGAQQFGPRVGLRQHAERVERAQRAAEGRGGGGGGGCGAQAHRRVVGQGQ 536
              G    GP  G            +AA G   GG         +R  GQ Q
Sbjct: 315 QQGGGMMMGPGGG------GAASLSKAAAGSAAGG--------FQRFAGQNQ 352



 Score = 38.9 bits (89), Expect = 0.028
 Identities = 58/216 (26%), Positives = 74/216 (34%), Gaps = 37/216 (17%)

Query: 360 HKPSSHTSLANQGARSEERGARLAESRGRGVTPRASWSR-QPAGGPLSS----EGHLLPL 414
           H  S++ SL   G  + + G  + + +  G    A+  +  P G PL S    E    P 
Sbjct: 74  HPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPK 133

Query: 415 VQRDGGGLAEHRG------REGEEGVRAGGGGTGEVR------GGGSPGRQPVGRAAVTG 462
           +    GG  EH G      ++    V  GGGG   V       G  +P     G     G
Sbjct: 134 MGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPG-----G 188

Query: 463 EAGAGAAGRGAQSVRGPGVERRV-AEGAQQFGPRVGLRQHAERVERAQ---------RAA 512
            AG      G Q   G G+     A  A   G    L+   E    +Q           A
Sbjct: 189 RAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGA 248

Query: 513 EGRGGGGGGGCGAQAHRRVVGQGQVRWEGVGQAARG 548
            G GGGGGGG G        G G     G G A  G
Sbjct: 249 GGGGGGGGGGGGGSG-----GGGGGGGAGAGGAGAG 279


>gi|239755920 PREDICTED: hypothetical protein XP_002344746 [Homo
           sapiens]
          Length = 600

 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 69/218 (31%), Positives = 85/218 (38%), Gaps = 27/218 (12%)

Query: 382 LAESRGRGVTPRASWSRQPAGGPLSSEGHLLPLVQRDGGGLAEHRGREGEE--GVRAGGG 439
           L E  G+G   R   S + +G      GH   +  RD GG   +RG+EG    G  AG G
Sbjct: 371 LLEVEGQGGRGRPGQSLRRSG-----RGHGRGIQARDTGGGPRNRGQEGTHASGRHAGEG 425

Query: 440 GTGEVRGGGSPGRQPVGRAAVTGEAGAGAAGRGAQS-VRGPGV----ERR----VAEGAQ 490
                  G    R PV         G   A +GA   VRG  V    ERR      E A+
Sbjct: 426 APHGKLAGVQEERVPVEELLARQARGEAEARQGALGQVRGGRVRLHRERREGLLARERAR 485

Query: 491 QF--GPRVGLRQHAERVERAQRAAEGRGGGGGGG----CGAQAHRRVVGQG---QVRWEG 541
            F  G R  L   A  + RAQ A+ GR GGG        G Q   R  G G   Q+  + 
Sbjct: 486 LFHLGRRCALANRAPALLRAQAASAGRDGGGAMAPQMRLGPQGGERDAGLGRPHQLIHDR 545

Query: 542 VGQAARGRRMAHHCSQGRNSQSRHQPGRDRPHHHHLEL 579
           +GQ AR R      + GR  Q   +      H  H E+
Sbjct: 546 LGQGARQRERRR--AVGRQRQRGEERRLVTQHRAHGEV 581



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 53/182 (29%), Positives = 68/182 (37%), Gaps = 27/182 (14%)

Query: 425 HRGREGEEGVRAGGGGTGEVRGGGSPGRQPVGRAAVTGEAGAGAAGR----GAQSVRGPG 480
           HRGR G +G      G    R GG  G +           G GA  +    G Q   G  
Sbjct: 271 HRGRAGGQGGDFAVQGPRGRRHGGQGGGEQTAAVRDRHRDGVGAVAQPRAHGVQIEEGVA 330

Query: 481 VER----RVAEGAQQFGPRVGLRQHAERVERAQR--------AAEGRGGGGGGGCGAQAH 528
           V R    R   G +    RVG+R+ A      Q           EG+GG G  G   +  
Sbjct: 331 VHRAGGCRRGGGRRCGHVRVGVREQASERGHGQALGGQDVLLEVEGQGGRGRPGQSLRRS 390

Query: 529 RRVVGQG-QVRWEGVGQAARGRRMAHHCSQGRNSQSRHQPGRDRPHHHHLELESLRERVP 587
            R  G+G Q R  G G   RG+       +G ++  RH  G   PH     ++   ERVP
Sbjct: 391 GRGHGRGIQARDTGGGPRNRGQ-------EGTHASGRH-AGEGAPHGKLAGVQ--EERVP 440

Query: 588 CE 589
            E
Sbjct: 441 VE 442



 Score = 35.4 bits (80), Expect = 0.31
 Identities = 44/154 (28%), Positives = 56/154 (36%), Gaps = 21/154 (13%)

Query: 434 VRAGGGGTGEVRGGGSPGRQPVGRAAVTGEAGAGAAGRGAQSVRGPGVERRVAEGAQQ-- 491
           +RA  G  G   GG   G     RA V    G      G  +V+GP   R   +G  +  
Sbjct: 242 LRAEFGRQGHGAGGERGGAAVEFRARVHCHRGRAGGQGGDFAVQGPRGRRHGGQGGGEQT 301

Query: 492 ----------FGPRVGLRQHAERVER--AQRAAEGRGGGGGGGCGAQAHRRVVGQGQVRW 539
                      G     R H  ++E   A   A G   GGG  CG   H RV  + Q   
Sbjct: 302 AAVRDRHRDGVGAVAQPRAHGVQIEEGVAVHRAGGCRRGGGRRCG---HVRVGVREQASE 358

Query: 540 EGVGQAARGR----RMAHHCSQGRNSQSRHQPGR 569
            G GQA  G+     +     +GR  QS  + GR
Sbjct: 359 RGHGQALGGQDVLLEVEGQGGRGRPGQSLRRSGR 392



 Score = 31.2 bits (69), Expect = 5.8
 Identities = 35/126 (27%), Positives = 49/126 (38%), Gaps = 15/126 (11%)

Query: 464 AGAGAAGRGAQSVR-GPGVERRVAEGAQQFGPRVGLRQHAERVERAQRAAEGRGGGGGGG 522
           +G G  GR A  VR G     +  +  Q  G R+ LR    R         G GG  GG 
Sbjct: 207 SGTGLRGRAAGPVRLGFQAANQPLDALQFAGGRLFLRAEFGR------QGHGAGGERGGA 260

Query: 523 CGAQAHRRVVGQGQVRWEGVGQAARGRRMAHHCSQGRNSQS-----RHQPGRD---RPHH 574
                 R    +G+   +G   A +G R   H  QG   Q+     RH+ G     +P  
Sbjct: 261 AVEFRARVHCHRGRAGGQGGDFAVQGPRGRRHGGQGGGEQTAAVRDRHRDGVGAVAQPRA 320

Query: 575 HHLELE 580
           H +++E
Sbjct: 321 HGVQIE 326


>gi|239750393 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 373

 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 77/301 (25%), Positives = 100/301 (33%), Gaps = 58/301 (19%)

Query: 359 IHKPSSHTSLANQGARSEERGARLAESRG---RGVTPRASWSR---QPAGGPL------- 405
           I +    T L+    R      RLA   G   R   PRA   R   +PA G +       
Sbjct: 73  IRRNPLRTQLSGSPPRRPTSVLRLASPAGDLPRRPRPRAGGGRHSPRPAVGTIFRGGRKG 132

Query: 406 ---SSEGHLLPLVQRDGGGLAEHRGREGEEGVRAGGGGTGEVRGGGSPGRQPVG------ 456
                 G L    +R G GL   R R    G+ A  GG    RG G  G + +G      
Sbjct: 133 RLREGRGALRGSGKRRGWGLRPQRVRSRLAGLGAPRGGAAAPRGWGGQGAERLGVHQPGL 192

Query: 457 --RAAVTGEAGAGAAGRGAQSVRGPGVER-----------RVAEGAQQFGPRVGLRQHAE 503
              AA+ G  G    G G      P   +           R+   A++   R  L +H +
Sbjct: 193 PTHAALRGGGGGSEGGGGGARPSPPRARQPPSGRPRPRRTRLLGSAERHTGRAALARHGQ 252

Query: 504 RVERAQRAAEGRGGGGGGGC-----------GAQAHRRVVGQGQVRWEGVGQAARGRRMA 552
            + R   A      G G              GA+ HRR  G+ +    G  Q   G   A
Sbjct: 253 -LSRPHAAVRNSSRGRGAATSVSAAARPTRGGARGHRRADGRAR---GGCAQLRAGTPSA 308

Query: 553 HHCSQ---GRNSQSRHQPGRD----RPHHHHLELESLRERVPCEPPPPLPPLLLGVSLPP 605
               Q   GR  +    P R      PH H        + +P   PPP PP L    LPP
Sbjct: 309 PGGLQDCRGRQGEENAHPFRSGAPFSPHPHASRSTLAAQLLPLPQPPP-PPKLAPPPLPP 367

Query: 606 F 606
           +
Sbjct: 368 W 368


>gi|239744740 PREDICTED: hypothetical protein XP_002343259 [Homo
           sapiens]
          Length = 457

 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 69/218 (31%), Positives = 85/218 (38%), Gaps = 27/218 (12%)

Query: 382 LAESRGRGVTPRASWSRQPAGGPLSSEGHLLPLVQRDGGGLAEHRGREGEE--GVRAGGG 439
           L E  G+G   R   S + +G      GH   +  RD GG   +RG+EG    G  AG G
Sbjct: 228 LLEVEGQGGRGRPGQSLRRSG-----RGHGRGIQARDTGGGPRNRGQEGTHASGRHAGEG 282

Query: 440 GTGEVRGGGSPGRQPVGRAAVTGEAGAGAAGRGAQS-VRGPGV----ERR----VAEGAQ 490
                  G    R PV         G   A +GA   VRG  V    ERR      E A+
Sbjct: 283 APHGKLAGVQEERVPVEELLARQARGEAEARQGALGQVRGGRVRLHRERREGLLARERAR 342

Query: 491 QF--GPRVGLRQHAERVERAQRAAEGRGGGGGGG----CGAQAHRRVVGQG---QVRWEG 541
            F  G R  L   A  + RAQ A+ GR GGG        G Q   R  G G   Q+  + 
Sbjct: 343 LFHLGRRCALANRAPALLRAQAASAGRDGGGAMAPQMRLGPQGGERDAGLGRPHQLIHDR 402

Query: 542 VGQAARGRRMAHHCSQGRNSQSRHQPGRDRPHHHHLEL 579
           +GQ AR R      + GR  Q   +      H  H E+
Sbjct: 403 LGQGARQRERRR--AVGRQRQRGEERRLVTQHRAHGEV 438



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 53/182 (29%), Positives = 68/182 (37%), Gaps = 27/182 (14%)

Query: 425 HRGREGEEGVRAGGGGTGEVRGGGSPGRQPVGRAAVTGEAGAGAAGR----GAQSVRGPG 480
           HRGR G +G      G    R GG  G +           G GA  +    G Q   G  
Sbjct: 128 HRGRAGGQGGDFAVQGPRGRRHGGQGGGEQTAAVRDRHRDGVGAVAQPRAHGVQIEEGVA 187

Query: 481 VER----RVAEGAQQFGPRVGLRQHAERVERAQR--------AAEGRGGGGGGGCGAQAH 528
           V R    R   G +    RVG+R+ A      Q           EG+GG G  G   +  
Sbjct: 188 VHRAGGCRRGGGRRCGHVRVGVREQASERGHGQALGGQDVLLEVEGQGGRGRPGQSLRRS 247

Query: 529 RRVVGQG-QVRWEGVGQAARGRRMAHHCSQGRNSQSRHQPGRDRPHHHHLELESLRERVP 587
            R  G+G Q R  G G   RG+       +G ++  RH  G   PH     ++   ERVP
Sbjct: 248 GRGHGRGIQARDTGGGPRNRGQ-------EGTHASGRH-AGEGAPHGKLAGVQ--EERVP 297

Query: 588 CE 589
            E
Sbjct: 298 VE 299



 Score = 35.4 bits (80), Expect = 0.31
 Identities = 44/154 (28%), Positives = 56/154 (36%), Gaps = 21/154 (13%)

Query: 434 VRAGGGGTGEVRGGGSPGRQPVGRAAVTGEAGAGAAGRGAQSVRGPGVERRVAEGAQQ-- 491
           +RA  G  G   GG   G     RA V    G      G  +V+GP   R   +G  +  
Sbjct: 99  LRAEFGRQGHGAGGERGGAAVEFRARVHCHRGRAGGQGGDFAVQGPRGRRHGGQGGGEQT 158

Query: 492 ----------FGPRVGLRQHAERVER--AQRAAEGRGGGGGGGCGAQAHRRVVGQGQVRW 539
                      G     R H  ++E   A   A G   GGG  CG   H RV  + Q   
Sbjct: 159 AAVRDRHRDGVGAVAQPRAHGVQIEEGVAVHRAGGCRRGGGRRCG---HVRVGVREQASE 215

Query: 540 EGVGQAARGR----RMAHHCSQGRNSQSRHQPGR 569
            G GQA  G+     +     +GR  QS  + GR
Sbjct: 216 RGHGQALGGQDVLLEVEGQGGRGRPGQSLRRSGR 249



 Score = 31.2 bits (69), Expect = 5.8
 Identities = 35/126 (27%), Positives = 49/126 (38%), Gaps = 15/126 (11%)

Query: 464 AGAGAAGRGAQSVR-GPGVERRVAEGAQQFGPRVGLRQHAERVERAQRAAEGRGGGGGGG 522
           +G G  GR A  VR G     +  +  Q  G R+ LR    R         G GG  GG 
Sbjct: 64  SGTGLRGRAAGPVRLGFQAANQPLDALQFAGGRLFLRAEFGR------QGHGAGGERGGA 117

Query: 523 CGAQAHRRVVGQGQVRWEGVGQAARGRRMAHHCSQGRNSQS-----RHQPGRD---RPHH 574
                 R    +G+   +G   A +G R   H  QG   Q+     RH+ G     +P  
Sbjct: 118 AVEFRARVHCHRGRAGGQGGDFAVQGPRGRRHGGQGGGEQTAAVRDRHRDGVGAVAQPRA 177

Query: 575 HHLELE 580
           H +++E
Sbjct: 178 HGVQIE 183


>gi|239744694 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 373

 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 77/301 (25%), Positives = 100/301 (33%), Gaps = 58/301 (19%)

Query: 359 IHKPSSHTSLANQGARSEERGARLAESRG---RGVTPRASWSR---QPAGGPL------- 405
           I +    T L+    R      RLA   G   R   PRA   R   +PA G +       
Sbjct: 73  IRRNPLRTQLSGSPPRRPTSVLRLASPAGDLPRRPRPRAGGGRHSPRPAVGTIFRGGRKG 132

Query: 406 ---SSEGHLLPLVQRDGGGLAEHRGREGEEGVRAGGGGTGEVRGGGSPGRQPVG------ 456
                 G L    +R G GL   R R    G+ A  GG    RG G  G + +G      
Sbjct: 133 RLREGRGALRGSGKRRGWGLRPQRVRSRLAGLGAPRGGAAAPRGWGGQGAERLGVHQPGL 192

Query: 457 --RAAVTGEAGAGAAGRGAQSVRGPGVER-----------RVAEGAQQFGPRVGLRQHAE 503
              AA+ G  G    G G      P   +           R+   A++   R  L +H +
Sbjct: 193 PTHAALRGGGGGSEGGGGGARPSPPRARQPPSGRPRPRRTRLLGSAERHTGRAALARHGQ 252

Query: 504 RVERAQRAAEGRGGGGGGGC-----------GAQAHRRVVGQGQVRWEGVGQAARGRRMA 552
            + R   A      G G              GA+ HRR  G+ +    G  Q   G   A
Sbjct: 253 -LSRPHAAVRNSSRGRGAATSVSAAARPTRGGARGHRRADGRAR---GGCAQLRAGTPSA 308

Query: 553 HHCSQ---GRNSQSRHQPGRD----RPHHHHLELESLRERVPCEPPPPLPPLLLGVSLPP 605
               Q   GR  +    P R      PH H        + +P   PPP PP L    LPP
Sbjct: 309 PGGLQDCRGRQGEENAHPFRSGAPFSPHPHASRSTLAAQLLPLPQPPP-PPKLAPPPLPP 367

Query: 606 F 606
           +
Sbjct: 368 W 368


>gi|169204930 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 373

 Score = 50.8 bits (120), Expect = 7e-06
 Identities = 76/301 (25%), Positives = 100/301 (33%), Gaps = 58/301 (19%)

Query: 359 IHKPSSHTSLANQGARSEERGARLAESRG---RGVTPRASWSR---QPAGGPL------- 405
           I +    T L+    R      RLA   G   R   PRA   R   +PA G +       
Sbjct: 73  IRRNPLRTQLSGSPPRRPTSVLRLASPAGDLPRRPRPRAGGGRHSPRPAVGTIFRGGRKG 132

Query: 406 ---SSEGHLLPLVQRDGGGLAEHRGREGEEGVRAGGGGTGEVRGGGSPGRQPVG------ 456
                 G +    +R G GL   R R    G+ A  GG    RG G  G + +G      
Sbjct: 133 RLREGRGAVRGSGKRRGWGLRPQRVRSRLAGLGAPRGGAAAPRGWGGQGAERLGVHQPGL 192

Query: 457 --RAAVTGEAGAGAAGRGAQSVRGPGVER-----------RVAEGAQQFGPRVGLRQHAE 503
              AA+ G  G    G G      P   +           R+   A++   R  L +H +
Sbjct: 193 PTHAALRGGGGGSEGGGGGARPSPPRARQPPSGRPRPRRTRLLGSAERHTGRAALARHGQ 252

Query: 504 RVERAQRAAEGRGGGGGGGC-----------GAQAHRRVVGQGQVRWEGVGQAARGRRMA 552
            + R   A      G G              GA+ HRR  G+ +    G  Q   G   A
Sbjct: 253 -LSRPHAAVRNSSRGRGAATSVSAAARPTRGGARGHRRADGRAR---GGCAQLRAGTPSA 308

Query: 553 HHCSQ---GRNSQSRHQPGRD----RPHHHHLELESLRERVPCEPPPPLPPLLLGVSLPP 605
               Q   GR  +    P R      PH H        + +P   PPP PP L    LPP
Sbjct: 309 PGGLQDCRGRQGEENAHPFRSGAPFSPHPHASRSTLAAQLLPLPQPPP-PPKLAPPPLPP 367

Query: 606 F 606
           +
Sbjct: 368 W 368


>gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens]
          Length = 1464

 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 101/415 (24%), Positives = 130/415 (31%), Gaps = 78/415 (18%)

Query: 137  SGPEGREATRARFPSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQSPEATSNLCRARNEAF 196
            +GP+G + +    P  +G R  +G +   G   A G +G      P   +    A  +  
Sbjct: 748  AGPKGADGS----PGKDGVRGLTGPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRG 803

Query: 197  RLQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDVLQSASGGSLF-------LGLPS--- 246
                  P    G   A G     G  GD G   D       G          +G P    
Sbjct: 804  EPGPPGPAGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKG 863

Query: 247  -------PGHTRPLPARGRREPEAGESEARPESPPQPQPRR----RLARRGPSASPGSWG 295
                   PG T    A GR  P      A P  PP P  +          GP+  PG  G
Sbjct: 864  ARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGPAGKEGGKGPRGETGPAGRPGEVG 923

Query: 296  ESHPQDDFQYEDNSDQDDPNQGAFLPAVLHPQVQTQFDQKTQVSALSSGVSGQLHGDHYY 355
               P      + +   D P   A  P    P  Q    Q+  V     G+ GQ  G+  +
Sbjct: 924  PPGPPGPAGEKGSPGADGP---AGAPGT--PGPQGIAGQRGVV-----GLPGQ-RGERGF 972

Query: 356  TFNIHKPSSHTSLANQGARSEERGARLAESRGRGVTPRASWSRQPAGGPLSSEGHLLPLV 415
               +  PS           S ERG            P          GP    G      
Sbjct: 973  P-GLPGPSGEPGKQGPSGASGERG------------PPGPMGPPGLAGPPGESG------ 1013

Query: 416  QRDGGGLAE-HRGREGEEGVRAGGGGTGEVRGGGSPGRQ----PVGRAAVTGEAG----A 466
             R+G   AE   GR+G  G +   G TG     G+PG      PVG A  +G+ G    A
Sbjct: 1014 -REGAPGAEGSPGRDGSPGAKGDRGETGPAGPPGAPGAPGAPGPVGPAGKSGDRGETGPA 1072

Query: 467  GAAGR-GAQSVRGPGVERRVAEGAQQFGPRVGLRQHAERVERAQRAAEGRGGGGG 520
            G AG  G    RGP             GP+       E  E+  R  +G  G  G
Sbjct: 1073 GPAGPVGPVGARGPA------------GPQGPRGDKGETGEQGDRGIKGHRGFSG 1115



 Score = 47.4 bits (111), Expect = 8e-05
 Identities = 91/363 (25%), Positives = 114/363 (31%), Gaps = 75/363 (20%)

Query: 134 GKGSGPEGREATRARFPSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQSPEATSNLCRARN 193
           G+  GP  R      FP  +G     G   +RGS    G +G P        + L  A+ 
Sbjct: 485 GERGGPGSRG-----FPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKG 539

Query: 194 EAFRLQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDV-LQSASGGSLFLGLPSPGHTRP 252
                    P    G     G + R G  G PG      +    G     G P     R 
Sbjct: 540 LTGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERG 599

Query: 253 LPAR-GRREPEAGESEARPESPPQPQ-PRRRLARRGPSASPGSWGESHPQDDFQYEDNSD 310
           +P   G   P   + EA  + PP P  P      +GP+ SPG  G   P           
Sbjct: 600 VPGPPGAVGPAGKDGEAGAQGPPGPAGPAGERGEQGPAGSPGFQGLPGPAG--------- 650

Query: 311 QDDPNQGAFLPAVLHPQVQTQFDQKTQVSALSSGVSGQLHGDHYYTFNIHKPSSHTSLAN 370
              P   A  P                      GV G L            PS       
Sbjct: 651 ---PPGEAGKPG-------------------EQGVPGDLGAPG--------PS------- 673

Query: 371 QGARSE-----ERGAR----LAESRGRGVTPRASWSRQPAGGPLSSEGHLLPLVQRDGGG 421
            GAR E     ERG +     A  RG    P    ++  AG P +      P +Q    G
Sbjct: 674 -GARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGSQGAPGLQ----G 728

Query: 422 LAEHRGREGEEGVRAGGGGTGEVRGGGSPGRQPVGRAAVTGEAG----AGAAG-RGAQSV 476
           +   RG  G  G +   G  G     GSPG+   G   +TG  G    AGA G +G    
Sbjct: 729 MPGERGAAGLPGPKGDRGDAGPKGADGSPGKD--GVRGLTGPIGPPGPAGAPGDKGESGP 786

Query: 477 RGP 479
            GP
Sbjct: 787 SGP 789



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 57/185 (30%), Positives = 69/185 (37%), Gaps = 21/185 (11%)

Query: 130  GASHGKGS----GPEGREATRARFPSPNG--KRRG----SGKLWKRGSFPAI-GLEGRPS 178
            G +  KGS    GP G   T    P P G   +RG     G+  +RG FP + G  G P 
Sbjct: 929  GPAGEKGSPGADGPAGAPGT----PGPQGIAGQRGVVGLPGQRGERG-FPGLPGPSGEPG 983

Query: 179  LQSPEATSNLCRARNEAFRLQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDVLQSASGG 238
             Q P   S             L  P    G+  A G E   GRDG PG   D  ++   G
Sbjct: 984  KQGPSGASGERGPPGPMGPPGLAGPPGESGREGAPGAEGSPGRDGSPGAKGDRGETGPAG 1043

Query: 239  SLFLGLP-SPGHTRPLPARGRREPEAGESEARPESPPQPQPRRRLARRGPSASPGSWGES 297
                G P +PG   P+   G+         A P  P  P   R  A  GP    G  GE+
Sbjct: 1044 P--PGAPGAPGAPGPVGPAGKSGDRGETGPAGPAGPVGPVGARGPA--GPQGPRGDKGET 1099

Query: 298  HPQDD 302
              Q D
Sbjct: 1100 GEQGD 1104



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 93/352 (26%), Positives = 119/352 (33%), Gaps = 60/352 (17%)

Query: 138 GPEGREATR-----ARFPSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQSPEATSNLCRAR 192
           GP G +  R     A  P   G R  SG    +G     G +G P   SP       +  
Sbjct: 245 GPPGPQGARGLPGTAGLPGMKGHRGFSGLDGAKGDAGPAGPKGEPG--SPGENGAPGQMG 302

Query: 193 NEAFRLQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDVLQSASGGSLFLG-LPSPGHTR 251
                 +  RP  P G   ARG +  TG  G PG         +G   F G + + G   
Sbjct: 303 PRGLPGERGRPGAP-GPAGARGNDGATGAAGPPGPT-----GPAGPPGFPGAVGAKGEAG 356

Query: 252 PLPARGRREPEAGESEARPESPPQPQPRRRLARRGPSASPGSWGESHPQDDFQYEDNSDQ 311
           P   RG   P+    E  P  P            GP+ +PG+ G+   +       N   
Sbjct: 357 PQGPRGSEGPQGVRGEPGPPGP--------AGAAGPAGNPGADGQPGAKG-----ANGAP 403

Query: 312 DDPNQGAFLPAVLHPQVQTQFDQKTQVSALSSGVSGQLHGDHYYTFNIHKPSSHTSLANQ 371
                  F P    P                SG  G   G      N  +P +  S  + 
Sbjct: 404 GIAGAPGF-PGARGP----------------SGPQGP-GGPPGPKGNSGEPGAPGSKGDT 445

Query: 372 GARSEERGARLAESRGRGVTPRASWSRQPAGGPLSSEGHLLPLVQRDGGGLAEHRGREGE 431
           GA+ E     +    G    P     ++ A G     G   P  +R G G    RG  G 
Sbjct: 446 GAKGEPGPVGVQGPPG----PAGEEGKRGARGEPGPTGLPGPPGERGGPG---SRGFPGA 498

Query: 432 EGVRAGGGGTGEVRGGGSPGRQPVGRAAVTGEAG-AGAAG-RGAQSVRG-PG 480
           +GV    G  GE    GSPG  P G     GEAG  G AG  GA+ + G PG
Sbjct: 499 DGVAGPKGPAGE---RGSPG--PAGPKGSPGEAGRPGEAGLPGAKGLTGSPG 545



 Score = 40.0 bits (92), Expect = 0.012
 Identities = 50/205 (24%), Positives = 61/205 (29%), Gaps = 33/205 (16%)

Query: 138  GPEGREATRARFPSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQSPEATSNLCRARNEAFR 197
            G  G E +  R  SP  K    G   + G     G  G P    P   +     R E   
Sbjct: 1016 GAPGAEGSPGRDGSPGAK----GDRGETGPAGPPGAPGAPGAPGPVGPAGKSGDRGETGP 1071

Query: 198  LQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDVLQSASGGSLFLGLPSPGHTRPLPARG 257
                 P  PVG     G +   G  G+ G   D  +   G   F GL  P    P  + G
Sbjct: 1072 AGPAGPVGPVGARGPAGPQGPRGDKGETGEQGD--RGIKGHRGFSGLQGP--PGPPGSPG 1127

Query: 258  RREPEAGESEARPESPP-------------------QPQPRRRLARRGPSASPGSWGESH 298
             + P      A P  PP                    P PR R    GP   PG  G   
Sbjct: 1128 EQGPSGASGPAGPRGPPGSAGAPGKDGLNGLPGPIGPPGPRGRTGDAGPVGPPGPPGPPG 1187

Query: 299  PQD------DFQYEDNSDQDDPNQG 317
            P        DF +     Q+  + G
Sbjct: 1188 PPGPPSAGFDFSFLPQPPQEKAHDG 1212



 Score = 39.3 bits (90), Expect = 0.021
 Identities = 88/357 (24%), Positives = 110/357 (30%), Gaps = 97/357 (27%)

Query: 138  GPEGREATRARFPSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQSPEATSNLCRARNEAFR 197
            GP G        P P GK  G G   + G  PA    GRP    P               
Sbjct: 887  GPSGNAGPPGP-PGPAGKEGGKGPRGETG--PA----GRPGEVGPPG------------- 926

Query: 198  LQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDVLQSASGGSLFLGLPS-------PGHT 250
                 P  P G+  + G +   G  G PG      Q  +G    +GLP        PG  
Sbjct: 927  -----PPGPAGEKGSPGADGPAGAPGTPGP-----QGIAGQRGVVGLPGQRGERGFPGLP 976

Query: 251  RPLPARGRREPEAGESEARPESPPQPQPRRRLARRGPSASPGSWGESHPQDDFQYEDNSD 310
             P    G++ P     E  P  P            GP    G  GES  ++     + S 
Sbjct: 977  GPSGEPGKQGPSGASGERGPPGP-----------MGPPGLAGPPGESG-REGAPGAEGSP 1024

Query: 311  QDDPNQGAFLPAVLHPQVQTQFDQKTQVSALSSGVSGQLHGDHYYTFNIHKPSSHTSLAN 370
              D + GA                                GD   T     P +  +   
Sbjct: 1025 GRDGSPGA-------------------------------KGDRGETGPAGPPGAPGAPGA 1053

Query: 371  QGARSEERGARLAESRGRGVTPRASWSRQPAG--GPLSSEGHLLPLVQRDGGGLAEHRGR 428
             G           +S  RG T  A     PAG  GP+ + G   P   R   G    +G 
Sbjct: 1054 PGPVGPA-----GKSGDRGETGPAG----PAGPVGPVGARGPAGPQGPRGDKGETGEQGD 1104

Query: 429  EGEEGVRAGGGGTGEVRGGGSPGRQ-PVGRAAVTGEAG----AGAAGR-GAQSVRGP 479
             G +G R   G  G     GSPG Q P G +   G  G    AGA G+ G   + GP
Sbjct: 1105 RGIKGHRGFSGLQGPPGPPGSPGEQGPSGASGPAGPRGPPGSAGAPGKDGLNGLPGP 1161



 Score = 38.9 bits (89), Expect = 0.028
 Identities = 92/372 (24%), Positives = 117/372 (31%), Gaps = 74/372 (19%)

Query: 125 SRSREGASHGKGS-GPEGREATRARFPSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQSPE 183
           +R  +GA+   G  GP G  A    FP   G +  +G    RGS    G+ G P    P 
Sbjct: 321 ARGNDGATGAAGPPGPTG-PAGPPGFPGAVGAKGEAGPQGPRGSEGPQGVRGEPGPPGPA 379

Query: 184 ATSNLCRARNEAFRLQLQRPQRPVGQTQARGYEPRTGRDGDPG-TNWDVLQSASGGSLFL 242
             +                   P G   A G     G +G PG         A G S   
Sbjct: 380 GAAG------------------PAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPS--- 418

Query: 243 GLPSPGHTRPLPARGRREPEA----GESEARPESPP-----QPQPRRRLARRGPSASPGS 293
           G   PG   P P     EP A    G++ A+ E  P      P P     +RG    PG 
Sbjct: 419 GPQGPGGP-PGPKGNSGEPGAPGSKGDTGAKGEPGPVGVQGPPGPAGEEGKRGARGEPGP 477

Query: 294 WGESHPQDDFQYEDNSDQDDPNQGAFLPAVLHPQVQTQFDQKTQVSALSSGVSGQLHGDH 353
            G   P          ++  P    F  A                 A   G +G+     
Sbjct: 478 TGLPGPP--------GERGGPGSRGFPGA--------------DGVAGPKGPAGERGSP- 514

Query: 354 YYTFNIHKPSSHTSLANQGARSEERGARLAESRGRGVTPRASWSRQPAG--GPLSSEGHL 411
                   P+       +  R  E G  L  ++G   +P +       G  GP   +G  
Sbjct: 515 -------GPAGPKGSPGEAGRPGEAG--LPGAKGLTGSPGSPGPDGKTGPPGPAGQDGRP 565

Query: 412 LPLVQRDGGGLAEHRGREGEEGVRAGGGGTGEVRGGGSPGRQPVGRAAVTGEAGAGAAGR 471
            P       G A   G  G +G     G  GE    G PG   VG A   GEAGA    +
Sbjct: 566 GPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPG--AVGPAGKDGEAGA----Q 619

Query: 472 GAQSVRGPGVER 483
           G     GP  ER
Sbjct: 620 GPPGPAGPAGER 631



 Score = 36.2 bits (82), Expect = 0.18
 Identities = 90/364 (24%), Positives = 109/364 (29%), Gaps = 54/364 (14%)

Query: 137 SGPEGREATRARFPSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQSPEATSNLCRARNEAF 196
           +GP G    +    SP G +   G     G     G +G P        S     R    
Sbjct: 625 AGPAGERGEQGPAGSP-GFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPG 683

Query: 197 RLQLQRPQRPVGQTQARGYEPRTGRDGDPGT-------NWDVLQSASGGSLFLGLPSP-- 247
              +Q P  P G   A G     G  GD G            LQ   G     GLP P  
Sbjct: 684 ERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGSQGAPGLQGMPGERGAAGLPGPKG 743

Query: 248 --GHTRPLPARGRREPEAGESEARPESPPQPQPRRRLARRGPSASPGSWGESHPQDDF-- 303
             G   P  A G    +       P  PP           GP+ +PG  GES P      
Sbjct: 744 DRGDAGPKGADGSPGKDGVRGLTGPIGPP-----------GPAGAPGDKGESGPSGPAGP 792

Query: 304 -----QYEDNSDQDDPNQGAFLPAVLHPQVQTQFDQKTQVSALSSGVSGQLHGDHYYTFN 358
                   D  +   P    F      P    Q   K +     +G  G   G       
Sbjct: 793 TGARGAPGDRGEPGPPGPAGFAGP---PGADGQPGAKGEPG--DAGAKGDA-GPPGPAGP 846

Query: 359 IHKPSSHTSLANQGARSEERGARLAESRGRGVTPRASWSRQPAG--GPLSSEGHLLPLVQ 416
              P    ++   GA+          +RG    P A+     AG  GP    G+  P   
Sbjct: 847 AGPPGPIGNVGAPGAKG---------ARGSAGPPGATGFPGAAGRVGPPGPSGNAGP--- 894

Query: 417 RDGGGLAEHRGREGEEGVRAGGGGTGEVRGGGSPGRQPVGRAAVTGEAG-AGAAGR-GAQ 474
               G A   G +G  G     G  GEV   G PG  P G     G  G AGA G  G Q
Sbjct: 895 PGPPGPAGKEGGKGPRGETGPAGRPGEVGPPGPPG--PAGEKGSPGADGPAGAPGTPGPQ 952

Query: 475 SVRG 478
            + G
Sbjct: 953 GIAG 956



 Score = 35.4 bits (80), Expect = 0.31
 Identities = 96/401 (23%), Positives = 130/401 (32%), Gaps = 39/401 (9%)

Query: 129 EGASHGKGSGPEGREATRARFPSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQSPEATSNL 188
           +G    KG+      A    FP   G R  SG     G     G  G P     +  +  
Sbjct: 391 DGQPGAKGANGAPGIAGAPGFP---GARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTG- 446

Query: 189 CRARNEAFRLQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDVLQSASGGSLFLGLP-SP 247
             A+ E   + +Q P  P G+   RG     G  G PG   +      GG    G P + 
Sbjct: 447 --AKGEPGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGE-----RGGPGSRGFPGAD 499

Query: 248 GHTRPL-PARGRREPEAGESEARPESPPQPQPRRRLARRGPSASPGSWGESHPQDDFQYE 306
           G   P  PA  R  P     +  P    +P        +G + SPGS G     D     
Sbjct: 500 GVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPGP----DGKTGP 555

Query: 307 DNSDQDDPNQGAFLPAVLHPQVQTQFDQKTQVSALSSGVSGQLHGDHYYTFNIHKPSSHT 366
                 D   G   P     Q         + +A   G +G+  G       +       
Sbjct: 556 PGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGE-RGVPGPPGAVGPAGKDG 614

Query: 367 SLANQGARSEERGARLAESRGRGVTPRASWSRQPAGGPLSS-----EGHLLPLVQRDGGG 421
               QG       A     +G   +P       PAG P  +     +G    L      G
Sbjct: 615 EAGAQGPPGPAGPAGERGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSG 674

Query: 422 LAEHRGREGEEGVRAGGGGTGEVRGGGSPGRQPVGRAAVTGEAGA-GAAG-RGAQSVRGP 479
               RG  GE GV+   G  G     G+PG          G+AGA GA G +GA  ++G 
Sbjct: 675 ARGERGFPGERGVQGPPGPAGPRGANGAPGND-----GAKGDAGAPGAPGSQGAPGLQGM 729

Query: 480 GVERRVAEGAQQFGPRVGLRQHAERVERAQRAAEGRGGGGG 520
             ER  A      GP+       +R +   + A+G  G  G
Sbjct: 730 PGERGAAGLP---GPK------GDRGDAGPKGADGSPGKDG 761



 Score = 33.1 bits (74), Expect = 1.5
 Identities = 73/296 (24%), Positives = 95/296 (32%), Gaps = 51/296 (17%)

Query: 243 GLPSP-GHTRPLPARGRREPEAGES-EARPESPPQPQPRRRLARRGPSASPGSWGESHPQ 300
           G+  P G T P   RG   P   +    +P  P  P P       GP   PG  G   PQ
Sbjct: 109 GVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPP------GPPGPPGLGGNFAPQ 162

Query: 301 DDFQYEDNSDQDDPNQGAFLPAVLHPQVQTQFDQKTQVSALSSGVSGQ--LHGDHYYTFN 358
             + Y++ S       G  +P  + P                 G+ G     G   +   
Sbjct: 163 LSYGYDEKS-----TGGISVPGPMGPSGPR-------------GLPGPPGAPGPQGFQGP 204

Query: 359 IHKPSSHTSLANQGARSEERGARLAESRGRGVTPRASWSRQPAGGPLSSEGHLLPLVQRD 418
             +P    +    G R            G    P     R P G P  + G     +   
Sbjct: 205 PGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPG-PQGARG-----LPGT 258

Query: 419 GG--GLAEHRGREGEEGVRAGGGGTGEVRGGGSPGRQ----PVGRAAVTGEAG------- 465
            G  G+  HRG  G +G +   G  G     GSPG       +G   + GE G       
Sbjct: 259 AGLPGMKGHRGFSGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGP 318

Query: 466 AGAAGR-GAQSVRGPGVERRVAEGAQQFGPRVGLRQHAERVERAQRAAEGRGGGGG 520
           AGA G  GA    GP      A G   F   VG +   E   +  R +EG  G  G
Sbjct: 319 AGARGNDGATGAAGPPGPTGPA-GPPGFPGAVGAK--GEAGPQGPRGSEGPQGVRG 371



 Score = 30.8 bits (68), Expect = 7.6
 Identities = 41/128 (32%), Positives = 46/128 (35%), Gaps = 13/128 (10%)

Query: 401 AGGPLSSEGHLLPLVQRDGGGLAEHRGREGEEGVRAGGGGTGEVRGGGSPGRQPVGRAAV 460
           A GP+   G   P  +    G A   GR GE G     G  G     G PG +  G    
Sbjct: 213 ASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMK--GHRGF 270

Query: 461 TGEAGA-GAAGRGAQSVRGPGVERRVAEGAQQFGPRVGLRQHAERVERAQRAAEGRGG-- 517
           +G  GA G AG               A G  Q GPR GL       ER +  A G  G  
Sbjct: 271 SGLDGAKGDAGPAGPKGEPGSPGENGAPG--QMGPR-GLPG-----ERGRPGAPGPAGAR 322

Query: 518 GGGGGCGA 525
           G  G  GA
Sbjct: 323 GNDGATGA 330


>gi|48762934 alpha 2 type I collagen [Homo sapiens]
          Length = 1366

 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 114/440 (25%), Positives = 149/440 (33%), Gaps = 75/440 (17%)

Query: 129 EGASHGKG----SGPEGREATRARFPSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQSPEA 184
           +G S  KG    +GP+G        P P+G+    GK    G   + G  G P L+    
Sbjct: 354 KGESGNKGEPGSAGPQGP-------PGPSGEE---GKRGPNGEAGSAGPPGPPGLRGSPG 403

Query: 185 TSNLCRARNEAFRLQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDVLQSASGGSLF--- 241
           +  L  A   A  +     +   G    RG     GR G+PG         S G++    
Sbjct: 404 SRGLPGADGRAGVMGPPGSRGASGPAGVRGPNGDAGRPGEPGLMGPRGLPGSPGNIGPAG 463

Query: 242 ----LGLPS----PGHTRPLPARGRREPEAGESEARPESPPQPQPRRRLA-------RRG 286
               +GLP     PG   P  ARG            P   P     +  A         G
Sbjct: 464 KEGPVGLPGIDGRPGPIGPAGARGEPGNIGFPGPKGPTGDPGKNGDKGHAGLAGARGAPG 523

Query: 287 PSASPGSWGESHPQDDFQYEDNSDQDDPNQGAF--LPAVLHPQVQTQFDQKTQVSALSSG 344
           P  + G+ G   PQ         +Q  P    F  LP    P  +              G
Sbjct: 524 PDGNNGAQGPPGPQG--VQGGKGEQGPPGPPGFQGLPGPSGPAGEV-------------G 568

Query: 345 VSGQ--LHGDHYYTFNIHKPSSHTSLANQGARSEERGAR-LAESRGRGVTPRASWSRQPA 401
             G+  LHG+    F +  P+           S   G      SRG    P    ++   
Sbjct: 569 KPGERGLHGE----FGLPGPAGPRGERGPPGESGAAGPTGPIGSRGPSGPPGPDGNKGEP 624

Query: 402 G--------GPLSSEGHLLPLVQRDGGGLAEHRGREGEEGVRAGGGGTGEVRGGGSPGRQ 453
           G        GP    G  LP  +R   G+   +G +GE G+R   G  G     G+PG  
Sbjct: 625 GVVGAVGTAGPSGPSG--LP-GERGAAGIPGGKGEKGEPGLRGEIGNPGRDGARGAPGAV 681

Query: 454 PV-GRAAVTGEAG-AGAAG-RGAQSVRG-PGVERRVA-EGAQQF-GPRVGLRQHAERVER 507
              G A  TG+ G AGAAG  G    RG PG    V   G   F GP     Q   + ER
Sbjct: 682 GAPGPAGATGDRGEAGAAGPAGPAGPRGSPGERGEVGPAGPNGFAGPAGAAGQPGAKGER 741

Query: 508 AQRAAEGRGG--GGGGGCGA 525
             +  +G  G  G  G  GA
Sbjct: 742 GAKGPKGENGVVGPTGPVGA 761



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 98/395 (24%), Positives = 127/395 (32%), Gaps = 57/395 (14%)

Query: 130 GASHGKG-SGPEGREATRARFPSPNGKRR--GS----GKLWKRGSFPAIGLEGRPSLQSP 182
           GAS   G  GP G +A R   P   G R   GS    G   K G     G++GRP    P
Sbjct: 424 GASGPAGVRGPNG-DAGRPGEPGLMGPRGLPGSPGNIGPAGKEGPVGLPGIDGRPGPIGP 482

Query: 183 EATSNLCRARNEAFRLQLQRPQRPV---GQTQARGYEPRTGRDGDPGTNWD-------VL 232
                   AR E   +    P+ P    G+   +G+    G  G PG + +         
Sbjct: 483 AG------ARGEPGNIGFPGPKGPTGDPGKNGDKGHAGLAGARGAPGPDGNNGAQGPPGP 536

Query: 233 QSASGGSLFLGLPSPGHTRPLPARGRREPEAGESEARPESPP--QPQPRRRLARRGPSAS 290
           Q   GG    G P P   + LP       E G+   R        P P      RGP   
Sbjct: 537 QGVQGGKGEQGPPGPPGFQGLPGPSGPAGEVGKPGERGLHGEFGLPGPAGPRGERGP--- 593

Query: 291 PGSWGESHPQDDFQYEDNSDQDDPNQGAFLPAVL------HPQVQTQFDQKTQVSALSSG 344
           PG  G + P         S    P+     P V+       P   +    +   + +  G
Sbjct: 594 PGESGAAGPTGPIGSRGPSGPPGPDGNKGEPGVVGAVGTAGPSGPSGLPGERGAAGIPGG 653

Query: 345 VSGQLHGDHYYTFNIHKPSSHTSLANQGA--------RSEERGARLAESRGRGVTPRASW 396
              +  G+      I  P    +    GA         + +RG   A        PR S 
Sbjct: 654 KGEK--GEPGLRGEIGNPGRDGARGAPGAVGAPGPAGATGDRGEAGAAGPAGPAGPRGSP 711

Query: 397 SRQPAGGPLSSEGHLLPLVQRDGGGLAEHRGREGEEGVRAGGGGTGEVRGGGSPG-RQPV 455
             +   GP    G   P       G    RG +G +G     G TG V   G  G   P 
Sbjct: 712 GERGEVGPAGPNGFAGPAGAAGQPGAKGERGAKGPKGENGVVGPTGPVGAAGPAGPNGPP 771

Query: 456 GRAAVTGEAG-------AGAAGR----GAQSVRGP 479
           G A   G+ G        GAAGR    G   + GP
Sbjct: 772 GPAGSRGDGGPPGMTGFPGAAGRTGPPGPSGISGP 806



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 117/469 (24%), Positives = 147/469 (31%), Gaps = 79/469 (16%)

Query: 129 EGASHGKGS-GPEGREATRARFPSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQSPEATSN 187
           +G   GKG  GP G    +   P P+G     GK  +RG     GL G    +       
Sbjct: 537 QGVQGGKGEQGPPGPPGFQG-LPGPSGPAGEVGKPGERGLHGEFGLPGPAGPRGERGPPG 595

Query: 188 LCRARNEAFRLQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDVLQSASGGSLFLGLPSP 247
              A           P  P+G     G     G  G+PG    V    +G S   GLP  
Sbjct: 596 ESGAAG---------PTGPIGSRGPSGPPGPDGNKGEPGVVGAV--GTAGPSGPSGLPGE 644

Query: 248 GHTRPLPARGRREPEAGESEARPESPPQPQPRRRLARRGPSASPGSWGESHPQDDFQYED 307
                +P     + E GE   R E            R G   +PG+ G   P        
Sbjct: 645 RGAAGIPGG---KGEKGEPGLRGEIGNP-------GRDGARGAPGAVGAPGPA------- 687

Query: 308 NSDQDDPNQGAFLPAVLHPQVQTQFDQKTQVSALSSGVSGQLHGDHYYTFNIHKPSSHTS 367
            +  D    GA  PA       +  ++     A  +G +G                    
Sbjct: 688 GATGDRGEAGAAGPAGPAGPRGSPGERGEVGPAGPNGFAGP-----------------AG 730

Query: 368 LANQGARSEERGARLAESRGRGVTPRASWSRQPAGGPLSSEGHLLPLVQR-DGG------ 420
            A Q     ERGA+  +     V P        A GP    G   P   R DGG      
Sbjct: 731 AAGQPGAKGERGAKGPKGENGVVGPTGPVG---AAGPAGPNGPPGPAGSRGDGGPPGMTG 787

Query: 421 --GLAEHRGREGEEGVRAGGGGTGEVRGGGSPG----RQPVGRAAVTGEAGAGAAGRGAQ 474
             G A   G  G  G+    G  G     G  G    + PVGR   TGE GA     G  
Sbjct: 788 FPGAAGRTGPPGPSGISGPPGPPGPAGKEGLRGPRGDQGPVGR---TGEVGA-VGPPGFA 843

Query: 475 SVRGPGVERRVAEGAQQFGPR--VG----LRQHAERVERAQRAAEGRGG-----GGGGGC 523
             +GP  E   A      GP+  +G    L     R ER      G  G     G  G  
Sbjct: 844 GEKGPSGEAGTAGPPGTPGPQGLLGAPGILGLPGSRGERGLPGVAGAVGEPGPLGIAGPP 903

Query: 524 GAQAHRRVVGQGQVRWEGVGQAARGRRMAHHCSQGRNSQSRHQPGRDRP 572
           GA+     VG   V     G+A R     +    GR+ Q  H+  R  P
Sbjct: 904 GARGPPGAVGSPGVN-GAPGEAGRDGNPGNDGPPGRDGQPGHKGERGYP 951



 Score = 39.3 bits (90), Expect = 0.021
 Identities = 96/372 (25%), Positives = 115/372 (30%), Gaps = 50/372 (13%)

Query: 137 SGPEGREATRARF--PSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQSPEATSNLCRARNE 194
           +G  G    R R   P P G R   G +   G    IG  G P             A   
Sbjct: 213 TGARGLPGERGRVGAPGPAGARGSDGSVGPVGPAGPIGSAGPPGFPGAPGPKGEIGAVGN 272

Query: 195 AFRLQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDVLQSASGGSLFLGLPSPGHTRPLP 254
           A       P  P G+    G     G  G+PG N   L  A G +   GLP       LP
Sbjct: 273 A---GPAGPAGPRGEVGLPGLSGPVGPPGNPGANG--LTGAKGAA---GLPGVAGAPGLP 324

Query: 255 A-RGRREP--EAGESEARPESPPQPQPRRRLARRGPSASPGSWGESHPQDDFQYEDNSDQ 311
             RG   P   AG + AR     +P P       G    PGS G   P      E     
Sbjct: 325 GPRGIPGPVGAAGATGAR-GLVGEPGPAGSKGESGNKGEPGSAGPQGPPGPSGEEGKRGP 383

Query: 312 DDPNQGAFLPAVLHPQVQTQFDQKTQVSALSSGVSGQLHGDHYYTFNIHKPSSHTSLANQ 371
           +     A  P                     S  S  L G       +  P S  +    
Sbjct: 384 NGEAGSAGPPG--------------PPGLRGSPGSRGLPGADGRAGVMGPPGSRGASGPA 429

Query: 372 GARSEERGARLAESRGRGVTPRASWSRQPAGGPLSSEGHLLPLVQRDGGGLAEHRGREGE 431
           G R     A      GR   P     R   G P    G++ P  +    GL    GR G 
Sbjct: 430 GVRGPNGDA------GRPGEPGLMGPRGLPGSP----GNIGPAGKEGPVGLPGIDGRPGP 479

Query: 432 EGVRAGGGGTGEVRGGGSPG-RQPVGRAAVTGEAG-AGAAG-RGA------QSVRGPGVE 482
            G     G  G +   G PG + P G     G+ G AG AG RGA         +GP   
Sbjct: 480 IGPAGARGEPGNI---GFPGPKGPTGDPGKNGDKGHAGLAGARGAPGPDGNNGAQGPPGP 536

Query: 483 RRVAEGAQQFGP 494
           + V  G  + GP
Sbjct: 537 QGVQGGKGEQGP 548



 Score = 33.1 bits (74), Expect = 1.5
 Identities = 48/176 (27%), Positives = 59/176 (33%), Gaps = 21/176 (11%)

Query: 128 REGASHGKGS----GPEGREATR--ARFPSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQS 181
           R+GA    G+    GP G    R  A    P G     G   +RG    +G  G      
Sbjct: 671 RDGARGAPGAVGAPGPAGATGDRGEAGAAGPAGPAGPRGSPGERGE---VGPAGPNGFAG 727

Query: 182 PEATSNLCRARNEAFRLQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDVLQSASGGSLF 241
           P   +    A+ E      +     VG T   G     G +G PG           GS  
Sbjct: 728 PAGAAGQPGAKGERGAKGPKGENGVVGPTGPVGAAGPAGPNGPPGP---------AGSRG 778

Query: 242 LGLPSPGHTRPLPARGRREPEAGESEARPESPPQPQPRRRLARRGPSASPGSWGES 297
            G P PG T    A GR  P      + P  PP P  +  L  RGP    G  G +
Sbjct: 779 DGGP-PGMTGFPGAAGRTGPPGPSGISGPPGPPGPAGKEGL--RGPRGDQGPVGRT 831



 Score = 32.3 bits (72), Expect = 2.6
 Identities = 102/416 (24%), Positives = 126/416 (30%), Gaps = 63/416 (15%)

Query: 110 PRTPIKGTNWTAIHQSRSREGASHGKGSGPEGREATRARFPSPNGKRRGSGKLWKRGSFP 169
           P  P  G N+ A +     +G   G G GP G          P G    +G    +G   
Sbjct: 68  PGPPGLGGNFAAQY-----DGKGVGLGPGPMG-------LMGPRGPPGAAGAPGPQGFQG 115

Query: 170 AIGLEGRPSLQSPEATSNLCRARNEAFRL-QLQRPQRP-----VGQTQARGYEPRTGRDG 223
             G  G P    P           +A       +P RP     VG   ARG+    G  G
Sbjct: 116 PAGEPGEPGQTGPAGARGPAGPPGKAGEDGHPGKPGRPGERGVVGPQGARGFPGTPGLPG 175

Query: 224 DPG----TNWDVLQSASGGSLFLGLP-------SPGHT--RPLPARGRREPEAGESEARP 270
             G       D L+   G     G P       +PG T  R LP    R    G + AR 
Sbjct: 176 FKGIRGHNGLDGLKGQPGAPGVKGEPGAPGENGTPGQTGARGLPGERGRVGAPGPAGARG 235

Query: 271 E--SPPQPQPRRRLARRGPSASPGSWGESHPQDDFQYEDNSDQDDPNQGAFLPAVLHPQV 328
              S     P   +   GP   PG+ G             +    P     LP +  P  
Sbjct: 236 SDGSVGPVGPAGPIGSAGPPGFPGAPGPKGEIGAVGNAGPAGPAGPRGEVGLPGLSGPVG 295

Query: 329 QTQFDQKTQVSALSS-----GVSGQ--LHGDHYYTFNIHKPSSHTSLANQGARSEERGAR 381
                    ++         GV+G   L G          P    +    GAR       
Sbjct: 296 PPGNPGANGLTGAKGAAGLPGVAGAPGLPGPRGI------PGPVGAAGATGARGLVGEPG 349

Query: 382 LAESRGRGVTPRASWSRQPAG--GPLSSEGHLLPLVQRDGGGLAEHRGREGEEGVRAGGG 439
            A S+G         S  P G  GP   EG      +R   G A   G  G  G+R   G
Sbjct: 350 PAGSKGESGNKGEPGSAGPQGPPGPSGEEG------KRGPNGEAGSAGPPGPPGLRGSPG 403

Query: 440 GTGEVRGGGSPGRQPVGRAAVTGEAGAGAAGRGAQSVRGPGVERRVAEGAQQFGPR 495
                   G PG    GRA V G  G+  A  G   VRGP  +          GPR
Sbjct: 404 SR------GLPGAD--GRAGVMGPPGSRGAS-GPAGVRGPNGDAGRPGEPGLMGPR 450



 Score = 30.8 bits (68), Expect = 7.6
 Identities = 44/174 (25%), Positives = 56/174 (32%), Gaps = 14/174 (8%)

Query: 130  GASHGKGSGPEGREATRARFPSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQSPEATSNLC 189
            G +  KG   E   A     P P G     G L   GS    GL G            + 
Sbjct: 841  GFAGEKGPSGEAGTAGPPGTPGPQGLLGAPGILGLPGSRGERGLPGVAGAVGEPGPLGIA 900

Query: 190  RARNEAFRLQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDVLQSASGGSLFLGLPSPGH 249
                       + P   VG     G     GRDG+PG +    +    G        PG+
Sbjct: 901  GPPGA------RGPPGAVGSPGVNGAPGEAGRDGNPGNDGPPGRDGQPGHKG-ERGYPGN 953

Query: 250  TRPLPARGRREPE-----AGESEARPESPPQPQ--PRRRLARRGPSASPGSWGE 296
              P+ A G   P      AG+   R E+ P     P   +  RGPS   G  G+
Sbjct: 954  IGPVGAAGAPGPHGPVGPAGKHGNRGETGPSGPVGPAGAVGPRGPSGPQGIRGD 1007


>gi|239758013 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 819

 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 52/218 (23%), Positives = 85/218 (38%), Gaps = 24/218 (11%)

Query: 367 SLANQGARSEERGARLAESRGRGVTPRASWSRQPAGGPLSSEGHLLPLVQRDGGGLAEHR 426
           S  ++  +  +R A+    + RG   +     +PA G   S        +R GG   + +
Sbjct: 197 SRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKS--------RRGGGKKPQKQ 248

Query: 427 GREGEEGVRAGGGGTGEVRGGGSPGRQPVGR-AAVTGEAGAGAAGRGAQSVRGPGVERRV 485
            R G++    G    G+ RGGG    +  G+ AA+ G    GAA  G +    P  + R 
Sbjct: 249 RRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEK----PAAKGRG 304

Query: 486 AEGAQQFG---PRVGL-----RQHAERVERAQRAAEGRGGGG---GGGCGAQAHRRVVGQ 534
             G +  G   PR G      R+  ++  +A  A   RGGGG       G ++ ++   +
Sbjct: 305 GRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRR 364

Query: 535 GQVRWEGVGQAARGRRMAHHCSQGRNSQSRHQPGRDRP 572
           G+        AA  +       +G     R   GR +P
Sbjct: 365 GKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKP 402



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 104/472 (22%), Positives = 159/472 (33%), Gaps = 61/472 (12%)

Query: 126 RSREGASHGKGSGPEGREATRARFPSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQSPEAT 185
           ++ + A+ G   G  G++           K+R  GK  +R    A G + R         
Sbjct: 331 KATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDK---- 386

Query: 186 SNLCRARNEAFRLQLQRPQRPVGQTQ-ARGYEPRTGRDGDPGTNWDVLQSASGGSLFLGL 244
             L  A+      +  R Q P  + Q A   +PR G    P         + GG    G 
Sbjct: 387 KGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSG- 445

Query: 245 PSPGHTRPLPARGRREPEAGESEARPESPPQPQPRRRLARRGPSASPGSWGESHPQDDFQ 304
              G  +P   RG++  +   +EA  ES    +  R+ A    + S G   +SH   +  
Sbjct: 446 ---GGKKPR-RRGQKARQKA-AEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLW 500

Query: 305 YEDNSDQDDPNQGAFLPAVLHPQVQTQFDQKTQVSALSSGVSGQLHGDHYYTFNIHKPSS 364
                 +    +     A    + Q +  QK  V+   S V G             K   
Sbjct: 501 RRGQKAEAAGEKATAAGAKSRGRKQPR-RQKPAVAGAKSRVGGS------------KSRQ 547

Query: 365 HTSLANQGARSEERGARLAESRGRGVTPRASWSRQPAGGPLSSEGHLLPLVQRDGGGLAE 424
                  GA S   G    +SRG G      W +  A       G   P  Q+   G+ +
Sbjct: 548 RQKAVAAGATSHGGGGN-KQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTK 606

Query: 425 HR-GREGEEGVRAGGGGTGE------------------------VRGGGSPGRQPVGR-- 457
            R G  G++  R    GTG                             GS G+QP  +  
Sbjct: 607 SRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKP 666

Query: 458 -AAVTGEAGAGAAGRGAQSVRGPGVERRVAEGAQQFGPRVGLRQHAERVERAQRAAEGRG 516
            AA +  + A A G+ A++ + P   R  + G       VG+     R ++  R  + RG
Sbjct: 667 AAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKK-PRLGKSRG 725

Query: 517 GGGGGGCGAQAHRRVVGQGQVRWEGVGQAARGRRMAHHCSQGRNSQSRHQPG 568
           GGG       A  R  G  + R  G  ++  G++ A   S G     R + G
Sbjct: 726 GGG-------AKSRGSGGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGG 770



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 55/252 (21%), Positives = 89/252 (35%), Gaps = 30/252 (11%)

Query: 334 QKTQVSALSSGVSGQLHGDHYYTFNIHKPSSHTSLANQGARSEERGARLAESRG-RGVTP 392
           +K ++      V+G+    H+      K +      N+G   ++  A   +S G RG  P
Sbjct: 69  KKARLRGQKGAVAGKEARQHW-----QKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKP 123

Query: 393 RASWSRQPAGGPLSSEGHLLPLVQRDGGGLAEHRGREGEEGVRAGGGGTGEVRGGGSPGR 452
           R    +  A G            Q+     +++RG   ++   A G     V+  G    
Sbjct: 124 RRRGQKAAATGSKKPRWR----AQKSAAAGSKNRGAGAQKAAAAAG-----VKSQGGEKP 174

Query: 453 QPVGRAAVTGEAGAGAAGRGAQSVRGPGVERRVAEGAQQFG-PRVGLRQHAERVERAQRA 511
           Q    A     +G     RGA+S      + R  E   +FG  R G R+   R + A   
Sbjct: 175 QKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGG 234

Query: 512 AEGRGGGG--------------GGGCGAQAHRRVVGQGQVRWEGVGQAARGRRMAHHCSQ 557
           A+ R GGG               GG       R  G  ++R +G   A  G +     + 
Sbjct: 235 AKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATA 294

Query: 558 GRNSQSRHQPGR 569
           G    ++ + GR
Sbjct: 295 GEKPAAKGRGGR 306



 Score = 40.0 bits (92), Expect = 0.012
 Identities = 52/205 (25%), Positives = 74/205 (36%), Gaps = 22/205 (10%)

Query: 372 GARSEERGARLAESRGRGVTPRASWSRQPAGGPLSSEGHLLPLVQRDGGGLAEHRGREGE 431
           G +  ++  R  +    G   R   SR      L  +G    L      G A      GE
Sbjct: 241 GGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAAT----AGE 296

Query: 432 EGVRAGGGGTG-EVRGGGSP-----GRQPVGR---AAVTGEAGAGAAGRGAQSVRGPGVE 482
           +    G GG G +  GG +P     G++P  R   A     AG    G G Q     GV+
Sbjct: 297 KPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVK 356

Query: 483 RRVAEGAQQFGPRVGLRQHAERVERAQRAAEGRGGGGGGGCGAQAHRRVVGQGQVRWEGV 542
            R  +  +   PR        R + +   A+ RGGG   G   +A RR  G+ + RW+  
Sbjct: 357 SRKKQRRRGKKPR--------RQKASAAGAKSRGGGDKKGL-REAKRRGDGRKKPRWQNP 407

Query: 543 GQAARGRRMAHHCSQGRNSQSRHQP 567
            + A+    A     G     R  P
Sbjct: 408 RRRAQKAPAAKPRGGGSKKPRRRGP 432



 Score = 40.0 bits (92), Expect = 0.012
 Identities = 31/95 (32%), Positives = 37/95 (38%), Gaps = 7/95 (7%)

Query: 388 RGVTPRASWSRQPAGGPLSSEGHLLPLVQRDGGGLAEHRGREGEEGVRAGGGGTGEVRGG 447
           RG  PR   SR   G      G       R  GG     G++       GGGG    RGG
Sbjct: 714 RGKKPRLGKSRGGGGAKSRGSGGAK---SRGSGGAKSRSGKKAAASKSHGGGGAKRRRGG 770

Query: 448 GSPGRQPVGRAAVT--GEAGAGAAGRGAQSVRGPG 480
           G+  R   G  AVT  G+  A A G+    V+  G
Sbjct: 771 GAKSRS--GEKAVTAGGQKAAAAGGKKPPRVKSRG 803



 Score = 36.2 bits (82), Expect = 0.18
 Identities = 47/173 (27%), Positives = 65/173 (37%), Gaps = 32/173 (18%)

Query: 373 ARSEERGARLAESRGRGVTPRASWSRQPAGGPLSS---------EGHLLPLVQR-----D 418
           A +E+  A  A SRG G   +  W +  A G  SS         E    P  +R     D
Sbjct: 641 AAAEKAWATGATSRGSG-GKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGD 699

Query: 419 GGGLA-------EHRGREGEEGVRAGGGGTGEVRGGGSPGRQPVGRAAVTGE-------- 463
           GG  A       + RG++   G   GGGG      GG+  R   G  + +G+        
Sbjct: 700 GGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKSH 759

Query: 464 AGAGAAGRGAQSVRGPGVERRVAEGAQQFGPRVGLR--QHAERVERAQRAAEG 514
            G GA  R     +    E+ V  G Q+     G +  +   R  R Q+AA G
Sbjct: 760 GGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGRGQKAAAG 812



 Score = 32.7 bits (73), Expect = 2.0
 Identities = 37/123 (30%), Positives = 50/123 (40%), Gaps = 27/123 (21%)

Query: 361 KPSSHTSLANQGARSEERGARLAESRGRGVTPRASWSRQPAGGPLSSEGHLLPLVQRDGG 420
           KP    S    GA+S  RG+  A+SRG             +GG  S  G      +  GG
Sbjct: 717 KPRLGKSRGGGGAKS--RGSGGAKSRG-------------SGGAKSRSGKKAAASKSHGG 761

Query: 421 GLAEHR------GREGEEGVRAGGGGTGEVRGGGSPGRQPVGRAAVTGEAGAGAAGRGAQ 474
           G A+ R       R GE+ V AGG      +   + G++P  R    G  G  AA  G +
Sbjct: 762 GGAKRRRGGGAKSRSGEKAVTAGG-----QKAAAAGGKKP-PRVKSRGGRGQKAAAGGKK 815

Query: 475 SVR 477
            +R
Sbjct: 816 PLR 818


>gi|11386161 alpha 2 type IX collagen [Homo sapiens]
          Length = 689

 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 97/404 (24%), Positives = 141/404 (34%), Gaps = 73/404 (18%)

Query: 130 GASHGKG-SGPEGREATRARFPSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQSPEATSNL 188
           GAS  +G  GP G +  R  +P   G +  +G    +G   AIG  G P  + P      
Sbjct: 217 GASGEQGIPGPPGPQGIRG-YPGMAGPKGETGPHGYKGMVGAIGATGPPGEEGPRGPPGR 275

Query: 189 CRARNEAFRLQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDVLQSASGGSLFLGLP-SP 247
              + +     ++ PQ   G   A G     G+DG PGT         G +   G P SP
Sbjct: 276 AGEKGDEGSPGIRGPQGITGPKGATGPPGINGKDGTPGT-----PGMKGSAGQAGQPGSP 330

Query: 248 GHTRPLPARGRREPEAGESEARPESPPQPQPRRRLARRGPSASPGSWGESHPQDDFQYED 307
           GH       G+   + G  + + E  PQ  P       G S  PG  GE  P+ +     
Sbjct: 331 GHQGLAGVPGQPGTKGGPGD-QGEPGPQGLP-------GFSGPPGKEGEPGPRGE----- 377

Query: 308 NSDQDDPNQGAFLPAVLHPQVQTQFDQKTQVSALSSGVSGQLHGDHYYTFNIHKPSSHTS 367
                           + PQ                G+ GQ  GD      + +P     
Sbjct: 378 ----------------IGPQ----------------GIMGQ-KGDQGERGPVGQPGPQ-- 402

Query: 368 LANQGARSEERGARLAESRG-RGVT-PRASWSRQPAGGPLSSEGHLLPLVQRDGGGLAEH 425
              QG + E+    +   +G  GV   + S  +    G +   G      ++   G +  
Sbjct: 403 -GRQGPKGEQGPPGIPGPQGLPGVKGDKGSPGKTGPRGKVGDPGVAGLPGEKGEKGESGE 461

Query: 426 RGREGEEGVRAGGGGTGEVRGGGSPGRQ----PVGRAAVTGEAGA-GAAGRGAQSVRGPG 480
            G +G++GVR   G  G     G+PG Q    P G   + G  G  G  GR        G
Sbjct: 462 PGPKGQQGVRGEPGYPGPSGDAGAPGVQGYPGPPGPRGLAGNRGVPGQPGR-------QG 514

Query: 481 VERRVAEGAQQFGPRVGLRQHAERVERAQRAAEGRGGGGGGGCG 524
           VE R  +   Q    V L+   E++     +A+    G  G  G
Sbjct: 515 VEGR--DATDQHIVDVALKMLQEQLAEVAVSAKREALGAVGMMG 556


>gi|4504733 insulin receptor substrate 4 [Homo sapiens]
          Length = 1257

 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 58/277 (20%), Positives = 91/277 (32%), Gaps = 21/277 (7%)

Query: 329 QTQFDQKTQVSALSSGVSGQLHGDHYYTFNIHKPSSHTSLANQG------ARSEERGARL 382
           +++F+Q   + A+  G    L    + T     PS   + + +G       R   R   +
Sbjct: 374 RSRFEQFCHLRAIGDGEDEMLFTRRFVT-----PSEPVAHSRRGRLHLPRGRRSRRAVSV 428

Query: 383 AESRGRGVTPRASWSRQPAGGPLSSEGHLLPLVQRDGGGLAEHRGREGEEGVRAGGGGTG 442
             S  R + P  +  R PA  P +       +     G   E    +G+E     GG   
Sbjct: 429 PASFFRRLAPSPARPRHPAEAPNNGARLSSEVSGSGSGNFGEEGNPQGKEDQEGSGGDYM 488

Query: 443 EVRGGGSPGRQPVGRAAVTGEAGAGAAGRGAQSVRGPGVERRVAEGAQQFGPRVGLRQHA 502
            +   GS   +  G    +   G+ +   G     G G   R  +G+       G     
Sbjct: 489 PMNNWGSGNGRGSGGGQGSNGQGSSSHSSGGNQCSGEGQGSRGGQGSN------GQGSGG 542

Query: 503 ERVERAQRAAEGRGGGGGGGCGAQAHRRVVGQGQVRWEGVGQAARGRRMAHHCSQGRNSQ 562
            +  R  +   G  G GGG      H    GQG     G G   +          G+ S 
Sbjct: 543 NQCSRDGQGTAGGHGSGGGQRPGGGHGSGGGQGPGDGHGSG-GGKNSGGGKGSGSGKGSD 601

Query: 563 SRHQPGRD---RPHHHHLELESLRERVPCEPPPPLPP 596
              + G+    R +   L     ++  P  PPPP PP
Sbjct: 602 GDGERGKSLKKRSYFGKLTQSKQQQMPPPPPPPPPPP 638



 Score = 36.6 bits (83), Expect = 0.14
 Identities = 27/106 (25%), Positives = 43/106 (40%), Gaps = 1/106 (0%)

Query: 212  ARGYEPRTGRDGDPGTNWDVLQSASGGSLFLGLPSPGHTRPLPARGRREPEAGESEARPE 271
            A G++  + R   P  N    ++  G     G  +PG   P     R + +AG + A   
Sbjct: 1152 AAGFDSASARWFQPVANAADAEAVRGAQDVAGGSNPGAHNPSANLARGDNQAGGAAAAAA 1211

Query: 272  SPPQPQPRRRLARRGPSASPGSWGESHPQDDFQYEDNSDQDDPNQG 317
            +P  P   RR+ R        +  ++H + DF   DN   D P +G
Sbjct: 1212 APEPPPRSRRVPRPPEREDSDNDDDTHVRMDFARRDN-QFDSPKRG 1256


>gi|109452587 family with sequence similarity 98, member B isoform 1
           [Homo sapiens]
          Length = 433

 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 40/120 (33%), Positives = 43/120 (35%), Gaps = 21/120 (17%)

Query: 416 QRDGGGLAEHRGREGEEGVRAGGGGTGEVRGGGSPGRQPVGRAAVTGEAGAGAAGRGAQS 475
           Q  GGG     G  G  G   GGGG G    GG  G    G     G  G G  GRG   
Sbjct: 329 QEGGGGRGGWGGGGGGGGRGGGGGGGGRGGWGGGGGGWGGGGGGGGGWGGGGGGGRGGFQ 388

Query: 476 VRGP-----GVERRVAEGAQQFGPRVGLRQHAERVERAQRAAEGRGGGGGGGCGAQAHRR 530
            RG      G   R   G + +G   G                G GGGGGGG G   +RR
Sbjct: 389 GRGDYGGRGGYGGRGGYGGRGYGDPYG----------------GGGGGGGGGGGGGGYRR 432


>gi|4502951 collagen type III alpha 1 preproprotein [Homo sapiens]
          Length = 1466

 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 92/363 (25%), Positives = 114/363 (31%), Gaps = 86/363 (23%)

Query: 137  SGPEGREATRARFPSPN--GKRRGSGKLWKRGSFPAIGLEGRPSLQSPEATSNLCRARNE 194
            SGP+G         SP   G     G L   G   A GL G P +  P  +      + E
Sbjct: 920  SGPKGDAGQPGEKGSPGAQGPPGAPGPLGIAGITGARGLAGPPGMPGPRGSPGPQGVKGE 979

Query: 195  AFR-----LQLQR-PQRPVGQTQARGYEPRTGRDGDPGTNWDVLQSASGGSLFLGLPSPG 248
            + +     L  +R P  P G     G     GRDG+PG+  D L    G        SPG
Sbjct: 980  SGKPGANGLSGERGPPGPQGLPGLAGTAGEPGRDGNPGS--DGLPGRDG--------SPG 1029

Query: 249  HTRPLPARGRREPEAGESEARPESPPQPQPRRRLARRGPSASPGSWGESHPQDDFQYEDN 308
                    G+ +     S   P +P  P P   +   GP+   G  GES P         
Sbjct: 1030 --------GKGDRGENGSPGAPGAPGHPGPPGPV---GPAGKSGDRGESGPAGP------ 1072

Query: 309  SDQDDPNQGAFLPAVLHPQVQTQFDQKTQVSALSSGVSGQLHGDHYYTFNIHKPSSHTSL 368
                    GA  PA                     G  G              P      
Sbjct: 1073 -------AGAPGPA---------------------GSRGA-------------PGPQGPR 1091

Query: 369  ANQGARSEERGARLAESRGRGVTPRASWSRQPAG--------GPLSSEGHLLPLVQRDGG 420
             ++G   E   A +   RG    P A  S  PAG        GP    G + P       
Sbjct: 1092 GDKGETGERGAAGIKGHRGFPGNPGAPGSPGPAGQQGAIGSPGPAGPRGPVGPSGPPGKD 1151

Query: 421  GLAEHRGREGEEGVRAGGGGTGEVRGGGSPGRQPVGRAAVTGEAGAGAAGRGAQSVRGPG 480
            G + H G  G  G R   G  G     G PG QP G     G  G    G GA ++ G G
Sbjct: 1152 GTSGHPGPIGPPGPRGNRGERGSEGSPGHPG-QP-GPPGPPGAPGPCCGGVGAAAIAGIG 1209

Query: 481  VER 483
             E+
Sbjct: 1210 GEK 1212



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 47/170 (27%), Positives = 63/170 (37%), Gaps = 14/170 (8%)

Query: 138 GPEGREATRARFPSPNGKRRGSGKLWKRG--SFPAI-GLEGRPSLQSPEATSNLCRARNE 194
           GP G        P P G R  +G+  + G    P + G+ G P     +       ++ E
Sbjct: 504 GPAGERGA----PGPAGPRGAAGEPGRDGVPGGPGMRGMPGSPGGPGSDGKPGPPGSQGE 559

Query: 195 AFRLQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDVLQSASGGSLFLGLPSP-GHTRPL 253
           + R     P  P GQ    G+    G DG PG N +  +   GG    G P   G T P 
Sbjct: 560 SGRPGPPGPSGPRGQPGVMGFPGPKGNDGAPGKNGE--RGGPGGPGPQGPPGKNGETGPQ 617

Query: 254 PARGRREPEAGESEARPESPPQPQPRRRL-ARRGPSASPGSWGESHPQDD 302
              G   P   + +     PP PQ  + L    GP    G  GE  P+ D
Sbjct: 618 GPPGPTGPGGDKGDT---GPPGPQGLQGLPGTGGPPGENGKPGEPGPKGD 664



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 100/404 (24%), Positives = 129/404 (31%), Gaps = 83/404 (20%)

Query: 149 FPSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQSPEATSNLCRARNEAFRLQLQRPQRPVG 208
           FP   G R   G+  ++G   A GL+G   L            R      +  RP  P G
Sbjct: 259 FPGMKGHRGFDGRNGEKGETGAPGLKGENGLPGENGAPGPMGPRGAPG--ERGRPGLP-G 315

Query: 209 QTQARGYEPRTGRDGDPGTNWDVLQSASGGSLFLGLP-SPGHTRPLPARGRREPEAGESE 267
              ARG +   G DG PG          G + F G P + G   P  + G        S 
Sbjct: 316 AAGARGNDGARGSDGQPGP-----PGPPGTAGFPGSPGAKGEVGPAGSPG--------SN 362

Query: 268 ARPESPPQPQPRRRLARRGPSASPGSWGESHPQDDFQYEDNSDQDDPNQGAFLPAVLHPQ 327
             P    +P P+     +GP   PG  G                    +G   PA +   
Sbjct: 363 GAPGQRGEPGPQGHAGAQGPPGPPGING----------------SPGGKGEMGPAGIPGA 406

Query: 328 VQTQFDQKTQVSALSSGVSGQLHGDHYYTFNIHKPSSHTSLANQGARSEE--------RG 379
                 +     A ++G  G   G         +P  + +    G R E          G
Sbjct: 407 PGLMGARGPPGPAGANGAPGLRGG-------AGEPGKNGAKGEPGPRGERGEAGIPGVPG 459

Query: 380 ARLAESR-------GRGVTPRASWSRQPAG-----GPLSSEGHLLPLVQRDGGGLAEHRG 427
           A+  + +       G    P A+  R   G     GP    G   P  +R   G A  RG
Sbjct: 460 AKGEDGKDGSPGEPGANGLPGAAGERGAPGFRGPAGPNGIPGEKGPAGERGAPGPAGPRG 519

Query: 428 REGEEGVRAGGGGTGEVRGGGSPGRQPVGRAAVTGEAGA-GAAGR-GAQSVRGPGVERRV 485
             GE G     GG G     GSPG    G     G  G+ G +GR G     GP    R 
Sbjct: 520 AAGEPGRDGVPGGPGMRGMPGSPGGP--GSDGKPGPPGSQGESGRPGPPGPSGP----RG 573

Query: 486 AEGAQQF-GPRVGLRQHAERVERAQRAAEGRGG--GGGGGCGAQ 526
             G   F GP            +    A G+ G  GG GG G Q
Sbjct: 574 QPGVMGFPGP------------KGNDGAPGKNGERGGPGGPGPQ 605



 Score = 40.4 bits (93), Expect = 0.010
 Identities = 96/394 (24%), Positives = 117/394 (29%), Gaps = 67/394 (17%)

Query: 136  GSGPEGREATRARFPSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQSPEATSNLCRARNEA 195
            GSGP G        P P G +   G+    G   A G  G   L  P  ++        +
Sbjct: 847  GSGPAGP-------PGPQGVK---GERGSPGGPGAAGFPGARGLPGPPGSNGNPGPPGPS 896

Query: 196  FRLQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDVLQSASGGSLFLGLPSPGHTRPLPA 255
                   P  P G T A G    +G  GD G      Q    GS     P PG   PL  
Sbjct: 897  GSPGKDGPPGPAGNTGAPGSPGVSGPKGDAG------QPGEKGSPGAQGP-PGAPGPLGI 949

Query: 256  RGRREPEAGESEARPESPPQPQPRRRLARRGPSASPGSWGESHPQDDFQYEDNSDQDDPN 315
                   AG + AR  + P   P       GP  SPG  G             S +  P 
Sbjct: 950  -------AGITGARGLAGPPGMP-------GPRGSPGPQGVKGESGKPGANGLSGERGPP 995

Query: 316  QGAFLPAVLHPQVQTQFDQKTQVSALSSGVSGQLHGDHYYTFNIHKPSSHTSLANQGARS 375
                LP +               +A   G  G    D         P    S   +G R 
Sbjct: 996  GPQGLPGLAG-------------TAGEPGRDGNPGSDGL-------PGRDGSPGGKGDRG 1035

Query: 376  EERGARLAESRGRG-----VTPRASWSRQPAGGPLSSEGHLLPLVQRDGGGLAEHRGREG 430
            E        + G       V P      +   GP    G   P   R   G    RG +G
Sbjct: 1036 ENGSPGAPGAPGHPGPPGPVGPAGKSGDRGESGPAGPAGAPGPAGSRGAPGPQGPRGDKG 1095

Query: 431  EEGVRAGGGGTGEVRGGGSPGRQ----PVGRAAVTGEAGAGAAGRGAQSVRGPGVERRVA 486
            E G R   G  G     G+PG      P G+    G  G  A  RG     GP  +   +
Sbjct: 1096 ETGERGAAGIKGHRGFPGNPGAPGSPGPAGQQGAIGSPGP-AGPRGPVGPSGPPGKDGTS 1154

Query: 487  EGAQQFGPRVGLRQHAERVERAQRAAEGRGGGGG 520
                  GP         R  R +R +EG  G  G
Sbjct: 1155 GHPGPIGP------PGPRGNRGERGSEGSPGHPG 1182



 Score = 39.7 bits (91), Expect = 0.016
 Identities = 88/369 (23%), Positives = 109/369 (29%), Gaps = 80/369 (21%)

Query: 137 SGPEGREATRARFPSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQS---PEATSNLCRARN 193
           SGP G+      FP P G     GK  +RG     G +G P       P+          
Sbjct: 569 SGPRGQPGVMG-FPGPKGNDGAPGKNGERGGPGGPGPQGPPGKNGETGPQGPPGPTGPGG 627

Query: 194 EAFRLQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDV-LQSASGGSLFLGLPS----PG 248
           +        PQ   G     G     G+ G+PG   D     A GG    G P     PG
Sbjct: 628 DKGDTGPPGPQGLQGLPGTGGPPGENGKPGEPGPKGDAGAPGAPGGKGDAGAPGERGPPG 687

Query: 249 HTRPLPARGRREP---EAGESEARPESPPQPQPRRRLARRGPSASPGSWGESHPQDDFQY 305
                  RG   P   E G+  A P  PP       L  +G     G  G   P+     
Sbjct: 688 LAGAPGLRGGAGPPGPEGGKGAAGPPGPPGAAGTPGL--QGMPGERGGLGSPGPKG---- 741

Query: 306 EDNSDQDDPNQGAFLPAVLHPQVQTQFDQKTQVSALSSGVSGQLHGDHYYTFNIHKPSSH 365
            D  +   P                           + GV G+             P   
Sbjct: 742 -DKGEPGGPG--------------------------ADGVPGK-----------DGPRGP 763

Query: 366 TSLANQGARSEERGARLAESRGRGVTPRASWSRQPAGGPLSSEGHLLPLVQRDGGGLAEH 425
           T        + + G      +G G  P       P G P    G   P       G    
Sbjct: 764 TGPIGPPGPAGQPG-----DKGEGGAPGLPGIAGPRGSP-GERGETGP---PGPAGFPGA 814

Query: 426 RGREGEEGVRAGGGGTGEVRGGGSPG----------RQPVGRAAVTGEAGA----GAAG- 470
            G+ GE G +   G  GE   GG PG            P G   V GE G+    GAAG 
Sbjct: 815 PGQNGEPGGKGERGAPGEKGEGGPPGVAGPPGGSGPAGPPGPQGVKGERGSPGGPGAAGF 874

Query: 471 RGAQSVRGP 479
            GA+ + GP
Sbjct: 875 PGARGLPGP 883



 Score = 37.4 bits (85), Expect = 0.081
 Identities = 105/417 (25%), Positives = 132/417 (31%), Gaps = 64/417 (15%)

Query: 125 SRSREGASHGKGS-GPEGREATRARFPSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQSPE 183
           +R  +GA    G  GP G   T A FP   G +   G     GS  A G  G P  Q   
Sbjct: 319 ARGNDGARGSDGQPGPPGPPGT-AGFPGSPGAKGEVGPAGSPGSNGAPGQRGEPGPQGHA 377

Query: 184 ATSNLCRARNEAFRLQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDVLQSASGGSLFLG 243
                            Q P  P G   + G +   G  G PG        A G     G
Sbjct: 378 GA---------------QGPPGPPGINGSPGGKGEMGPAGIPG--------APGLMGARG 414

Query: 244 LPSPGHTRPLPARGRREPEAGESEARPESPPQPQPRRRLARRGPSASPGSWGESHPQDDF 303
            P P      P       E G++ A+ E    P PR      G    PG+ G        
Sbjct: 415 PPGPAGANGAPGLRGGAGEPGKNGAKGE----PGPRGERGEAGIPGVPGAKG-------- 462

Query: 304 QYEDNSDQDDPNQGA-FLPAVLHPQVQTQFDQKTQVSALSSGVSGQL--HGDHYYTFNIH 360
             ED  D      GA  LP     +    F    +  A  +G+ G+    G+        
Sbjct: 463 --EDGKDGSPGEPGANGLPGAAGERGAPGF----RGPAGPNGIPGEKGPAGER----GAP 512

Query: 361 KPSSHTSLANQGARSEERGARLAESRGRGVTPRASWSRQPAGGPLSS-----EGHLLPLV 415
            P+     A +  R    G      RG   +P    S    G P S       G   P  
Sbjct: 513 GPAGPRGAAGEPGRDGVPGG--PGMRGMPGSPGGPGSDGKPGPPGSQGESGRPGPPGPSG 570

Query: 416 QRDGGGLAEHRGREGEEGVRAGGGGTGEVRGGGSPGRQ-PVGRAAVTGEAG-AGAAGRGA 473
            R   G+    G +G +G     G  GE  G G PG Q P G+   TG  G  G  G G 
Sbjct: 571 PRGQPGVMGFPGPKGNDG---APGKNGERGGPGGPGPQGPPGKNGETGPQGPPGPTGPGG 627

Query: 474 -QSVRGPGVERRVAEGAQQFGPRVGLRQHAERVERAQRAAEGRGGGGGGGCGAQAHR 529
            +   GP   + +       GP     +  E   +    A G   GG G  GA   R
Sbjct: 628 DKGDTGPPGPQGLQGLPGTGGPPGENGKPGEPGPKGDAGAPG-APGGKGDAGAPGER 683



 Score = 32.0 bits (71), Expect = 3.4
 Identities = 35/127 (27%), Positives = 50/127 (39%), Gaps = 10/127 (7%)

Query: 137  SGPEGREATRARFPSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQSPEATSNLCRARNEAF 196
            SGP G++ T    P P G     G   +RGS  + G  G+P    P      C     A 
Sbjct: 1145 SGPPGKDGTSGH-PGPIGPPGPRGNRGERGSEGSPGHPGQPGPPGPPGAPGPCCGGVGAA 1203

Query: 197  RLQLQRPQRPVGQTQARGYEPRTGRDG-DPGTNWDVLQSA--SGGSLFLGLPSPGHTRPL 253
             +        +G  +A G+ P  G +  D   N D + ++  S       L SP  +R  
Sbjct: 1204 AI------AGIGGEKAGGFAPYYGDEPMDFKINTDEIMTSLKSVNGQIESLISPDGSRKN 1257

Query: 254  PARGRRE 260
            PAR  R+
Sbjct: 1258 PARNCRD 1264



 Score = 30.4 bits (67), Expect = 9.9
 Identities = 25/72 (34%), Positives = 31/72 (43%), Gaps = 12/72 (16%)

Query: 420 GGLAEHRGREGEEGVRAGGGGTGEVRGGGSPGRQ-PVGRAAVTGEAG----------AGA 468
           GGLA + G  G  G     G +G     GSPG Q P G     G +G          +G 
Sbjct: 167 GGLAGYPGPAGPPGPPGPPGTSGHPGSPGSPGYQGPPGEPGQAGPSGPPGPPGAIGPSGP 226

Query: 469 AGRGAQSVRGPG 480
           AG+  +S R PG
Sbjct: 227 AGKDGESGR-PG 237


>gi|187828892 calcium channel, alpha 1A subunit isoform 4 [Homo
            sapiens]
          Length = 2506

 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 95/390 (24%), Positives = 137/390 (35%), Gaps = 66/390 (16%)

Query: 140  EGREATRARFPSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQSPEATSNLCRARNEAFRLQ 199
            +GR A+  R P+ N +RRG      RG+  +   +  P  +S        R R + + L+
Sbjct: 2087 QGRAASMPRLPAENQRRRGR----PRGNNLSTISDTSPMKRSASVLGPKAR-RLDDYSLE 2141

Query: 200  LQRPQRPVGQTQA------RGYEPRTGR--DGDPGTNWDVLQSASGGSL-------FLGL 244
               P+      Q       R  E   GR  D D G   D+  +   G L         G 
Sbjct: 2142 RVPPEENQRHHQRRRDRSHRASERSLGRYTDVDTGLGTDLSMTTQSGDLPSKERDQERGR 2201

Query: 245  PSP------------GHTRPLPARGR---REPEAGESEARPE--SPPQPQPRRRLARRGP 287
            P               H  P P + R     P+ G + AR +  S    + R  +A R  
Sbjct: 2202 PKDRKHRQHHHHHHHHHHPPPPDKDRYAQERPDHGRARARDQRWSRSPSEGREHMAHRQG 2261

Query: 288  SAS------PGSWGESHPQDDFQYEDNSDQDDPNQGAFLPAVLH------PQVQTQFDQK 335
            S+S      P + G S P+   +    +        ++ P +        PQ Q Q  Q+
Sbjct: 2262 SSSVSGSPAPSTSGTSTPRRGRRQLPQTPSTPRPHVSYSPVIRKAGGSGPPQQQQQQQQQ 2321

Query: 336  TQVSALSSGVSGQLHGDHYYTFNIHKPSSHTSLANQGARS--EERGARLAESRGRGVTPR 393
             Q  A++        G   Y     +P +       G  S    R  R      R  +PR
Sbjct: 2322 QQQQAVARPGRAATSGPRRYPGPTAEPLAGDRPPTGGHSSGRSPRMERRVPGPARSESPR 2381

Query: 394  A---SWSRQPAGGPLSSEGHLLPLVQRDGGGLAEHRGREGEEGVRAGGGGTGEVRGGGSP 450
            A     +R PA GP  SEG   P   R  G    +RG + +E    G GG  E   G   
Sbjct: 2382 ACRHGGARWPASGPHVSEG---PPGPRHHG---YYRGSDYDEADGPGSGGGEEAMAGAYD 2435

Query: 451  GRQPVGRAAVTGEAGAGAAGRGAQSVRGPG 480
               PV  A+      +GA GR  ++ R  G
Sbjct: 2436 APPPVRHAS------SGATGRSPRTPRASG 2459



 Score = 37.0 bits (84), Expect = 0.11
 Identities = 51/198 (25%), Positives = 72/198 (36%), Gaps = 17/198 (8%)

Query: 361  KPSSHTSLANQGARSEERGARLAESRGRGVTPRASW-SRQPAGGPLSSEGHLLPLVQRDG 419
            +P+    L  Q A    R       R R  +  A   +R+P  G   +E      + R+G
Sbjct: 842  EPTVDQRLGQQRAEDFLRKQARYHDRARDPSGSAGLDARRPWAGSQEAE------LSREG 895

Query: 420  --GGLAEHRGREGEEGVRAGGGGTGEVRGGGSPGRQPVGRAAVTGEAGAGAAGRGAQSVR 477
              G  ++H  REG         G  E    G P R+ V R   + E+ +G+   GA    
Sbjct: 896  PYGRESDHHAREGSLEQPGFWEGEAERGKAGDPHRRHVHRQGGSRESRSGSPRTGAD--- 952

Query: 478  GPGVERRVAEGAQQFGPRVGLRQHAERVE--RAQRAAEGRGGGGGGGCGAQAHRR---VV 532
            G     R      + GP     + A   E  R  R  EG G G  GG   + HR      
Sbjct: 953  GEHRRHRAHRRPGEEGPEDKAERRARHREGSRPARGGEGEGEGPDGGERRRRHRHGAPAT 1012

Query: 533  GQGQVRWEGVGQAARGRR 550
             +G  R E   +  R R+
Sbjct: 1013 YEGDARREDKERRHRRRK 1030



 Score = 35.4 bits (80), Expect = 0.31
 Identities = 61/260 (23%), Positives = 83/260 (31%), Gaps = 38/260 (14%)

Query: 211  QARGYEPRTGRDGDPGTNWDVLQSASGGSLFLGLPSPGHT-RPLPARGRREPEAGESEAR 269
            +AR  + R  R   P    + +    G S   G P+P  +    P RGRR+     S  R
Sbjct: 2237 RARARDQRWSRS--PSEGREHMAHRQGSSSVSGSPAPSTSGTSTPRRGRRQLPQTPSTPR 2294

Query: 270  PE-------------SPPQPQPRR-------------RLARRGPSASPGSWGESHPQDDF 303
            P               PPQ Q ++             R A  GP   PG   E    D  
Sbjct: 2295 PHVSYSPVIRKAGGSGPPQQQQQQQQQQQQQAVARPGRAATSGPRRYPGPTAEPLAGDRP 2354

Query: 304  QYEDNSDQDDPNQGAFLPAVLH---PQVQTQFDQKTQVSA--LSSGVSGQLHGDHYYTFN 358
                +S    P     +P       P+       +   S   +S G  G  H  +Y   +
Sbjct: 2355 PTGGHSSGRSPRMERRVPGPARSESPRACRHGGARWPASGPHVSEGPPGPRHHGYYRGSD 2414

Query: 359  IHKPSSHTSLANQ----GARSEERGARLAESRGRGVTPRASWSRQPAGGPLSSEGHLLPL 414
              +     S   +    GA       R A S   G +PR   +  PA    S  G  LP 
Sbjct: 2415 YDEADGPGSGGGEEAMAGAYDAPPPVRHASSGATGRSPRTPRASGPACASPSRHGRRLPN 2474

Query: 415  VQRDGGGLAEHRGREGEEGV 434
                  GLA  RG    +G+
Sbjct: 2475 GYYPAHGLARPRGPGSRKGL 2494



 Score = 31.2 bits (69), Expect = 5.8
 Identities = 59/248 (23%), Positives = 84/248 (33%), Gaps = 43/248 (17%)

Query: 368  LANQGARSEERGARLAESRGRGVTPRASWSRQPAGGPLSSEGHLL--PLVQRDGGG---- 421
            +A++   S   G+    + G   TPR    RQ    P +   H+   P++++ GG     
Sbjct: 2256 MAHRQGSSSVSGSPAPSTSGTS-TPRRG-RRQLPQTPSTPRPHVSYSPVIRKAGGSGPPQ 2313

Query: 422  --LAEHRGREGEEGVRAGGGGTGEVRGGGSPGRQPVGRAAVTGEAGAGAAGRGAQSVRGP 479
                + + ++ +   R G   T   R    P  +P+        AG      G  S R P
Sbjct: 2314 QQQQQQQQQQQQAVARPGRAATSGPRRYPGPTAEPL--------AGDRPPTGGHSSGRSP 2365

Query: 480  GVERRVAEGAQQFGPRV--------------------GLRQHAERVERAQRAAEGRGGGG 519
             +ERRV   A+   PR                     G R H          A+G G GG
Sbjct: 2366 RMERRVPGPARSESPRACRHGGARWPASGPHVSEGPPGPRHHGYYRGSDYDEADGPGSGG 2425

Query: 520  GGGCGAQAHRRVVGQGQVRWEGVGQAARGRRMAHHCSQGRNSQSRHQPGRDRPHHHHLEL 579
            G    A A+        VR    G   R  R          S SRH  GR  P+ ++   
Sbjct: 2426 GEEAMAGAYD---APPPVRHASSGATGRSPRTPRASGPACASPSRH--GRRLPNGYYPAH 2480

Query: 580  ESLRERVP 587
               R R P
Sbjct: 2481 GLARPRGP 2488


>gi|89363017 alpha 2 type V collagen preproprotein [Homo sapiens]
          Length = 1499

 Score = 47.4 bits (111), Expect = 8e-05
 Identities = 98/423 (23%), Positives = 128/423 (30%), Gaps = 85/423 (20%)

Query: 128  REGASHGKGSGPEGREATRARFPSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQSPEATSN 187
            R G       G  G +  R   P P G    +G   ++G     GL G P  +    +  
Sbjct: 779  RGGIGEKGAEGTAGNDGARG-LPGPLGPPGPAGPTGEKGEPGPRGLVGPPGSRGNPGSRG 837

Query: 188  LCRARNEAFRLQLQRPQRPVGQTQARGYEPRTGRDGDPGTNW-------------DVLQS 234
                      +    PQ P GQ   +G     G+ GD G+               + +  
Sbjct: 838  ---ENGPTGAVGFAGPQGPDGQPGVKGEPGEPGQKGDAGSPGPQGLAGSPGPHGPNGVPG 894

Query: 235  ASGGSLFLGLP-------SPGHTRPLPARGRREPEAGESEARPESPP----QPQPRRRLA 283
              GG    G P       S G   P    G   P     E   E PP     P    R+ 
Sbjct: 895  LKGGRGTQGPPGATGFPGSAGRVGPPGPAGAPGPAGPLGEPGKEGPPGLRGDPGSHGRVG 954

Query: 284  RRGPSASPGSWGESHPQDDFQYEDNSDQDDPNQGAFLPAVLHPQVQTQFDQKTQVSALSS 343
             RGP+  PG  G+         ED     D   G                         +
Sbjct: 955  DRGPAGPPGGPGDKGDPG----EDGQPGPDGPPG------------------------PA 986

Query: 344  GVSGQLHGDHYYTFNIHKPSSHTSLANQGARSEERGARLAESRGR--GVTPRASWSRQPA 401
            G +GQ                   +   G R E     L    G    V P  +   +  
Sbjct: 987  GTTGQ----------------RGIVGMPGQRGERGMPGLPGPAGTPGKVGPTGATGDKGP 1030

Query: 402  GGPLSSEGHLLPLVQRDGGGLAEHRGREGEEGVRAGGGGTGEVRGGGSPGRQPVGRAAVT 461
             GP+   G   P+ +    G A + G  G +G     G  G+    G PG Q  G     
Sbjct: 1031 PGPVGPPGSNGPVGEPGPEGPAGNDGTPGRDGAVGERGDRGDPGPAGLPGSQ--GAPGTP 1088

Query: 462  GEAGA-GAAG-RGAQSVRGP-----GVERRVAEGAQQFGPRVGLRQHAERVERAQRAAEG 514
            G  GA G AG RG    RGP        +R   G Q  GPR     H +R +R Q+   G
Sbjct: 1089 GPVGAPGDAGQRGDPGSRGPIGPPGRAGKRGLPGPQ--GPRGDKGDHGDRGDRGQKGHRG 1146

Query: 515  RGG 517
              G
Sbjct: 1147 FTG 1149



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 100/420 (23%), Positives = 134/420 (31%), Gaps = 65/420 (15%)

Query: 126 RSREGASHGKGS-GPEGREATRARFPSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQSPEA 184
           R R G +   GS GP G    + R P P G +   G+    G   A G  G PS   P+ 
Sbjct: 128 RGRPGPAGPPGSQGPRGERGPKGR-PGPRGPQGIDGEPGVPGQPGAPGPPGHPSHPGPDG 186

Query: 185 TSNLCRARNEAFRLQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDVLQSASGGSLFLGL 244
            S                  RP    Q  G + ++G     G                  
Sbjct: 187 LS------------------RPFS-AQMAGLDEKSGLGSQVGL----------------- 210

Query: 245 PSPGHTRPLPARGRREPEAGESEARPESPP----QPQPRRRLARRGPSASPGSWGE-SHP 299
             PG   P+  RG +  +  +  A P  PP     P P   +  RGP   PG  GE   P
Sbjct: 211 -MPGSVGPVGPRGPQGLQGQQGGAGPTGPPGEPGDPGPMGPIGSRGPEGPPGKPGEDGEP 269

Query: 300 QDDFQYEDNSDQDDPNQGAF-----LPAVL-HPQVQTQFDQKTQVSALSS----GVSGQL 349
             +    +      P    F     LP +  H   +     K +V A  S    G +G +
Sbjct: 270 GRNGNPGEVGFAGSPGARGFPGAPGLPGLKGHRGHKGLEGPKGEVGAPGSKGEAGPTGPM 329

Query: 350 HGDHYYTFNIHKPSSHTSLANQGARSEERGARLAESRGRGVTPRASWSRQPAGGPLSSEG 409
            G          P     L  QGA   +RGA     +   + P          G    +G
Sbjct: 330 -GAMGPLGPRGMPGERGRLGPQGAPG-QRGAHGMPGKPGPMGPLGIPGSSGFPGNPGMKG 387

Query: 410 HLLPLVQRDGGGLAEHRGREGEEGVRAGGGGTGEVRGGGSPG-RQPVGRAAVTGEAG-AG 467
              P   R   G    RG  G  G     G  G +   G+PG + P G    +G  G AG
Sbjct: 388 EAGPTGARGPEGPQGQRGETGPPGPVGSPGLPGAIGTDGTPGAKGPTGSPGTSGPPGSAG 447

Query: 468 AAG-------RGAQSVRGPGVERRVAEGAQQFGPRVGLRQHAERVERAQRAAEGRGGGGG 520
             G        G Q +RG   +  V     + GP+     H  +        EG+ G  G
Sbjct: 448 PPGSPGPQGSTGPQGIRGQPGDPGVPGFKGEAGPKGEPGPHGIQGPIGPPGEEGKRGPRG 507



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 92/379 (24%), Positives = 122/379 (32%), Gaps = 66/379 (17%)

Query: 138 GPEGREATRARFPS--PNGKRRGSGKLWKRGSFPAIGLEGRPSLQSPEATSNLCRARNEA 195
           GP+G +  R    S  P G +   G+  + G   A GL G P +Q PE       A  E 
Sbjct: 537 GPKGAQGERGPVGSSGPKGSQGDPGRPGEPGLPGARGLTGNPGVQGPEGKLGPLGAPGED 596

Query: 196 FRLQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDVLQSASGGSLFLGLP----SPGHTR 251
            R        P G    RG     G  G  G++ D  +    G+   G+P    +PG   
Sbjct: 597 GR------PGPPGSIGIRGQPGSMGLPGPKGSSGDPGKPGEAGN--AGVPGQRGAPGKDG 648

Query: 252 PLPARGRREPEAGESEARPESPPQPQPRRRLARRGPSASPGSWGESHPQDDFQYEDNSDQ 311
            +   G   P     E   + PP P   + L   GP   PG  G+             DQ
Sbjct: 649 EVGPSGPVGPPGLAGERGEQGPPGPTGFQGLP--GPPGPPGEGGKP-----------GDQ 695

Query: 312 DDPNQGAFLPAVLHPQVQTQFDQKTQVSALSSGVSGQLHGDHYYTFNIHKPSSHTSLANQ 371
             P      P  + P +  + ++         G++G L G+       H P         
Sbjct: 696 GVPGD----PGAVGP-LGPRGERGNPGERGEPGITG-LPGEKGMAGG-HGPDGPKGSPGP 748

Query: 372 GARSEERG----ARLAESRGRGVTPRASWSRQPAG-----------------GPLSSEGH 410
                + G      +   RG   TP     R   G                 GPL   G 
Sbjct: 749 SGTPGDTGPPGLQGMPGERGIAGTPGPKGDRGGIGEKGAEGTAGNDGARGLPGPLGPPGP 808

Query: 411 LLPLVQR---DGGGLAEHRGREGEEGVRAGGGGTGEVRGGGSPGRQPVGRAAVTGEAG-- 465
             P  ++      GL    G  G  G R   G TG V   G  G  P G+  V GE G  
Sbjct: 809 AGPTGEKGEPGPRGLVGPPGSRGNPGSRGENGPTGAVGFAGPQG--PDGQPGVKGEPGEP 866

Query: 466 ---AGAAGRGAQSVRG-PG 480
                A   G Q + G PG
Sbjct: 867 GQKGDAGSPGPQGLAGSPG 885



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 95/394 (24%), Positives = 123/394 (31%), Gaps = 88/394 (22%)

Query: 123  HQSRSREGASHGKGS-GPEGR-----EATRARFPSPNGKRRGSGKLWKRGSFPAIGLEGR 176
            H      G   G+G+ GP G       A R   P P G    +G L + G       EG 
Sbjct: 887  HGPNGVPGLKGGRGTQGPPGATGFPGSAGRVGPPGPAGAPGPAGPLGEPGK------EGP 940

Query: 177  PSLQSPEATSNLCRARNEAFRLQLQRPQRPVGQTQARGYEPRTGRDGDPGTNWDVLQSAS 236
            P L+    +      R  A       P    G     G + + G DG PG         +
Sbjct: 941  PGLRGDPGSHGRVGDRGPA------GPPGGPGDKGDPGEDGQPGPDGPPGP-----AGTT 989

Query: 237  GGSLFLGLPS-------PGHTRPLPARGRREPEAGESEARPESPPQPQPRRRLARRGPSA 289
            G    +G+P        PG   P    G+  P     +  P  P  P         GP  
Sbjct: 990  GQRGIVGMPGQRGERGMPGLPGPAGTPGKVGPTGATGDKGPPGPVGPP-----GSNGPVG 1044

Query: 290  SPGSWG----ESHPQDDFQYEDNSDQDDPNQGAFLPAVLHPQVQTQFDQKTQVSALSSGV 345
             PG  G    +  P  D    +  D+ DP   A LP        +Q    T     + G 
Sbjct: 1045 EPGPEGPAGNDGTPGRDGAVGERGDRGDPGP-AGLPG-------SQGAPGTPGPVGAPGD 1096

Query: 346  SGQLHGDHYYTFNIHKPSSHTSLANQGARSEERGARLAESRGRGVTPRASWSRQPAGGPL 405
            +GQ  GD         P S   +   G R+ +RG                       GP 
Sbjct: 1097 AGQ-RGD---------PGSRGPIGPPG-RAGKRGLP---------------------GPQ 1124

Query: 406  SSEGHLLPLVQRDGGGLAEHRGREGEEGVRAGGGGTGEVRGGGSPG----RQPVGRAAVT 461
               G       R   G   HRG  G +G+    G  GE    G PG    R P G    +
Sbjct: 1125 GPRGDKGDHGDRGDRGQKGHRGFTGLQGLPGPPGPNGEQGSAGIPGPFGPRGPPGPVGPS 1184

Query: 462  GEAG-AGAAGRGAQSVRGPGVERRVAEGAQQFGP 494
            G+ G  G  G     +  PGV   V E   +  P
Sbjct: 1185 GKEGNPGPLG----PIGPPGVRGSVGEAGPEGPP 1214



 Score = 32.7 bits (73), Expect = 2.0
 Identities = 39/160 (24%), Positives = 53/160 (33%), Gaps = 16/160 (10%)

Query: 150 PSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQSPEATSNLCRARNEAFRLQLQRPQRPVGQ 209
           P P G R G G+    G+    G  G P    P   +     + E     L  P    G 
Sbjct: 773 PGPKGDRGGIGEKGAEGTAGNDGARGLPGPLGPPGPAGPTGEKGEPGPRGLVGPPGSRGN 832

Query: 210 TQARGYEPRTGR---------DGDPGTNWDVLQSASGGSLFLGLPSP----GHTRPLPAR 256
             +RG    TG          DG PG   +  +    G    G P P    G   P    
Sbjct: 833 PGSRGENGPTGAVGFAGPQGPDGQPGVKGEPGEPGQKGD--AGSPGPQGLAGSPGPHGPN 890

Query: 257 GRREPEAGE-SEARPESPPQPQPRRRLARRGPSASPGSWG 295
           G    + G  ++  P +   P    R+   GP+ +PG  G
Sbjct: 891 GVPGLKGGRGTQGPPGATGFPGSAGRVGPPGPAGAPGPAG 930



 Score = 31.2 bits (69), Expect = 5.8
 Identities = 34/126 (26%), Positives = 42/126 (33%), Gaps = 3/126 (2%)

Query: 403 GPLSSEGHLLPLVQRDGGGLAEHRGREGEEGVRAGGGGTGEVRGGGSPGRQPVGRAAVTG 462
           GP    G   P+      G     G+ GE+G     G  GEV   GSPG +  G     G
Sbjct: 237 GPPGEPGDPGPMGPIGSRGPEGPPGKPGEDGEPGRNGNPGEVGFAGSPGAR--GFPGAPG 294

Query: 463 EAGAGAAGRGAQSVRGPGVERRVAEGAQQFGPRVGLRQHAERVERAQRAAEGRGGGGGGG 522
             G     RG + + GP  E        + GP   +        R      GR G  G  
Sbjct: 295 LPGL-KGHRGHKGLEGPKGEVGAPGSKGEAGPTGPMGAMGPLGPRGMPGERGRLGPQGAP 353

Query: 523 CGAQAH 528
               AH
Sbjct: 354 GQRGAH 359


>gi|51702521 POU domain, class 3, transcription factor 2 [Homo
           sapiens]
          Length = 443

 Score = 47.4 bits (111), Expect = 8e-05
 Identities = 63/252 (25%), Positives = 87/252 (34%), Gaps = 30/252 (11%)

Query: 363 SSHTSLANQGARSEERGARLAESRGRGVTPRASWSRQPAGGPLSSEGHLLPLVQRDGGGL 422
           S+H SL    A            +G G    A    Q   G L S GH L    +    L
Sbjct: 6   SNHYSLLTSSASIVHAEPPGGMQQGAGGYREAQSLVQGDYGALQSNGHPLSHAHQWITAL 65

Query: 423 AEHRGREGEEGVRAGGGGTGEVRGGGSP-GRQPVGRAAVTGEAGAGAAGRGAQSVRGPGV 481
           + H G  G  G   GGGG G   G GSP    P+G+  +         GRG   + GPG 
Sbjct: 66  S-HGGGGGGGGGGGGGGGGGGGGGDGSPWSTSPLGQPDIKPSVVVQQGGRG-DELHGPGA 123

Query: 482 ERRVAEGAQQFGPRVGLRQHAERVER-----AQRAAEGRGGGGGGGCGAQAHRRVVGQG- 535
            ++  +  QQ   +   +Q  ++ ++        AA    G G     A A       G 
Sbjct: 124 LQQQHQQQQQQQQQQQQQQQQQQQQQRPPHLVHHAANHHPGPGAWRSAAAAAHLPPSMGA 183

Query: 536 --------QVRWEGVGQAARGRRMA---HHCSQGRNSQSRHQPGRDRPHHHHLELESLRE 584
                   Q  +   G    G + A   HH  +  + +  H      PH H  +      
Sbjct: 184 SNGGLLYSQPSFTVNGMLGAGGQPAGLHHHGLRDAHDEPHHADHHPHPHSHPHQ------ 237

Query: 585 RVPCEPPPPLPP 596
               +PPPP PP
Sbjct: 238 ----QPPPPPPP 245



 Score = 37.7 bits (86), Expect = 0.062
 Identities = 47/198 (23%), Positives = 67/198 (33%), Gaps = 20/198 (10%)

Query: 130 GASHGKGSGPEGREATRARFPSPNGKRRGSGKLWKRGSFPAIGLEGRPSLQSPEATSNLC 189
           G   G G G +G   + +    P+ K     +   RG      L G  +LQ         
Sbjct: 79  GGGGGGGGGGDGSPWSTSPLGQPDIKPSVVVQQGGRGD----ELHGPGALQQQHQQQQQQ 134

Query: 190 RARNEAFRLQLQRPQRPVGQTQ-ARGYEPRTG--RDGDPGTNWDVLQSASGGSLFLGLPS 246
           + + +  + Q Q+ QRP      A  + P  G  R      +      AS G L    PS
Sbjct: 135 QQQQQQQQQQQQQQQRPPHLVHHAANHHPGPGAWRSAAAAAHLPPSMGASNGGLLYSQPS 194

Query: 247 ---------PGHTRPLPARGRR----EPEAGESEARPESPPQPQPRRRLARRGPSASPGS 293
                     G    L   G R    EP   +    P S P  QP      +GP   PG+
Sbjct: 195 FTVNGMLGAGGQPAGLHHHGLRDAHDEPHHADHHPHPHSHPHQQPPPPPPPQGPPGHPGA 254

Query: 294 WGESHPQDDFQYEDNSDQ 311
             + H  +D    D+ +Q
Sbjct: 255 HHDPHSDEDTPTSDDLEQ 272


>gi|239750438 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 510

 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 53/156 (33%), Positives = 63/156 (40%), Gaps = 18/156 (11%)

Query: 382 LAESRGRGVTPRASWSRQPAGGPLSSEGHLLPLVQRDGGGLAEHRGREGEE--GVRAGGG 439
           L E  G+G   R   S + +G      GH   +  RD GG   +RG+EG    G  AG G
Sbjct: 228 LLEVEGQGGRGRPGQSLRRSG-----RGHGRGIQARDTGGGPRNRGQEGTHASGRHAGEG 282

Query: 440 GTGEVRGGGSPGRQPVGRAAVTGEAGAGAAGRGAQS-VRGPGV----ERR----VAEGAQ 490
                  G    R PV         G   A +GA   VRG  V    ERR      E A+
Sbjct: 283 APHGKLAGVQEERVPVEELLARQARGEAEARQGALGQVRGGRVRLHRERREGLLARERAR 342

Query: 491 QF--GPRVGLRQHAERVERAQRAAEGRGGGGGGGCG 524
            F  G R  L   A  + RAQ A+ GR GGG    G
Sbjct: 343 LFHLGRRCALANRAPALLRAQAASAGRDGGGAMASG 378



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 53/182 (29%), Positives = 68/182 (37%), Gaps = 27/182 (14%)

Query: 425 HRGREGEEGVRAGGGGTGEVRGGGSPGRQPVGRAAVTGEAGAGAAGR----GAQSVRGPG 480
           HRGR G +G      G    R GG  G +           G GA  +    G Q   G  
Sbjct: 128 HRGRAGGQGGDFAVQGPRGRRHGGQGGGEQTAAVRDRHRDGVGAVAQPRAHGVQIEEGVA 187

Query: 481 VER----RVAEGAQQFGPRVGLRQHAERVERAQR--------AAEGRGGGGGGGCGAQAH 528
           V R    R   G +    RVG+R+ A      Q           EG+GG G  G   +  
Sbjct: 188 VHRAGGCRRGGGRRCGHVRVGVREQASERGHGQALGGQDVLLEVEGQGGRGRPGQSLRRS 247

Query: 529 RRVVGQG-QVRWEGVGQAARGRRMAHHCSQGRNSQSRHQPGRDRPHHHHLELESLRERVP 587
            R  G+G Q R  G G   RG+       +G ++  RH  G   PH     ++   ERVP
Sbjct: 248 GRGHGRGIQARDTGGGPRNRGQ-------EGTHASGRH-AGEGAPHGKLAGVQ--EERVP 297

Query: 588 CE 589
            E
Sbjct: 298 VE 299



 Score = 35.4 bits (80), Expect = 0.31
 Identities = 44/154 (28%), Positives = 56/154 (36%), Gaps = 21/154 (13%)

Query: 434 VRAGGGGTGEVRGGGSPGRQPVGRAAVTGEAGAGAAGRGAQSVRGPGVERRVAEGAQQ-- 491
           +RA  G  G   GG   G     RA V    G      G  +V+GP   R   +G  +  
Sbjct: 99  LRAEFGRQGHGAGGERGGAAVEFRARVHCHRGRAGGQGGDFAVQGPRGRRHGGQGGGEQT 158

Query: 492 ----------FGPRVGLRQHAERVER--AQRAAEGRGGGGGGGCGAQAHRRVVGQGQVRW 539
                      G     R H  ++E   A   A G   GGG  CG   H RV  + Q   
Sbjct: 159 AAVRDRHRDGVGAVAQPRAHGVQIEEGVAVHRAGGCRRGGGRRCG---HVRVGVREQASE 215

Query: 540 EGVGQAARGR----RMAHHCSQGRNSQSRHQPGR 569
            G GQA  G+     +     +GR  QS  + GR
Sbjct: 216 RGHGQALGGQDVLLEVEGQGGRGRPGQSLRRSGR 249



 Score = 31.2 bits (69), Expect = 5.8
 Identities = 35/126 (27%), Positives = 49/126 (38%), Gaps = 15/126 (11%)

Query: 464 AGAGAAGRGAQSVR-GPGVERRVAEGAQQFGPRVGLRQHAERVERAQRAAEGRGGGGGGG 522
           +G G  GR A  VR G     +  +  Q  G R+ LR    R         G GG  GG 
Sbjct: 64  SGTGLRGRAAGPVRLGFQAANQPLDALQFAGGRLFLRAEFGR------QGHGAGGERGGA 117

Query: 523 CGAQAHRRVVGQGQVRWEGVGQAARGRRMAHHCSQGRNSQS-----RHQPGRD---RPHH 574
                 R    +G+   +G   A +G R   H  QG   Q+     RH+ G     +P  
Sbjct: 118 AVEFRARVHCHRGRAGGQGGDFAVQGPRGRRHGGQGGGEQTAAVRDRHRDGVGAVAQPRA 177

Query: 575 HHLELE 580
           H +++E
Sbjct: 178 HGVQIE 183


>gi|25777671 protein phosphatase 1, regulatory subunit 10 [Homo
           sapiens]
          Length = 940

 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 49/143 (34%), Positives = 54/143 (37%), Gaps = 22/143 (15%)

Query: 400 PAGGPLSSEGHLLPLVQRDGGGLAE-HRGREGEEGVRAGGGG--TGEVRGGGSPGRQPVG 456
           P GG  +S GH     +  GGG+   HR  EG  G   GGGG    E  GGG  G    G
Sbjct: 757 PGGGMGNSSGHRPH--EGPGGGMGSGHRPHEGPGGSMGGGGGHRPHEGPGGGISGGS--G 812

Query: 457 RAAVTGEAGAGAAGRGAQSVRGPGVE------RRVAEGAQQFGPR-------VGLRQHAE 503
                G  G   AG G +   GPG         R  EG    GP         G R H  
Sbjct: 813 HRPHEGPGGGMGAGGGHRPHEGPGGSMGGSGGHRPHEGPGHGGPHGHRPHDVPGHRGHDH 872

Query: 504 R--VERAQRAAEGRGGGGGGGCG 524
           R       R  +G G GGGG  G
Sbjct: 873 RGPPPHEHRGHDGPGHGGGGHRG 895



 Score = 40.4 bits (93), Expect = 0.010
 Identities = 48/163 (29%), Positives = 53/163 (32%), Gaps = 36/163 (22%)

Query: 417 RDGGGLAEHRGREGEEGVRAGGGGTGEVRGGG---SPGRQPVGRAAVTGEAGAGAAGRGA 473
           R GGG    RG  G   V  GG    E  GGG   S G +P        E   G  G G 
Sbjct: 729 RSGGGPPNGRGGPGGGMVGGGGHRPHEGPGGGMGNSSGHRP-------HEGPGGGMGSGH 781

Query: 474 QSVRGPGVERRVAEGAQQFGPRVGLRQHAERVERAQRAAEGRGGGGGGGCGAQAHRRVVG 533
           +   GPG            G   G R H           EG GGG  GG G + H     
Sbjct: 782 RPHEGPG---------GSMGGGGGHRPH-----------EGPGGGISGGSGHRPH----- 816

Query: 534 QGQVRWEGVGQAARGRRMAHHCSQGRNSQSRHQ-PGRDRPHHH 575
           +G     G G   R          G      H+ PG   PH H
Sbjct: 817 EGPGGGMGAGGGHRPHEGPGGSMGGSGGHRPHEGPGHGGPHGH 859



 Score = 36.2 bits (82), Expect = 0.18
 Identities = 71/261 (27%), Positives = 86/261 (32%), Gaps = 71/261 (27%)

Query: 347 GQLHGDHYYTFNIHKPSSHTS--LANQGARSEERGARLAESRGRGVTPRASWSRQPAGGP 404
           G ++     T  +  P+SH S  L  Q   S++    L      G  P A+    P GGP
Sbjct: 577 GGINVQEILTSIMGSPNSHPSEELLKQPDYSDKIKQMLVPHGLLGPGPIANGF--PPGGP 634

Query: 405 LSSEG--HLLPLVQRDGGGL-AEHRGREGEEGVRAGG------GGT------------GE 443
              +G  H  P     GG +   H G  G  G R  G      GG             G 
Sbjct: 635 GGPKGMQHFPP---GPGGPMPGPHGGPGGPVGPRLLGPPPPPRGGDPFWDGPGDPMRGGP 691

Query: 444 VRGGGSPGRQPVGRAAVTGEAGAGAAGRGAQSVRGPGVERRVAEGAQQFGPRVGLRQHAE 503
           +RGG  PG  P  R         G  GRG      P    R A G +  G          
Sbjct: 692 MRGGPGPGPGPYHR---------GRGGRGGNEPPPPPPPFRGARGGRSGGG--------- 733

Query: 504 RVERAQRAAEGRGGGGGGGCGAQAHRRVVGQGQVRWEGVGQAARGRRMAHHCSQGRNSQS 563
                     GRGG GGG  G   HR   G G     G+G ++  R    H   G    S
Sbjct: 734 -------PPNGRGGPGGGMVGGGGHRPHEGPG----GGMGNSSGHR---PHEGPGGGMGS 779

Query: 564 RHQP-----------GRDRPH 573
            H+P           G  RPH
Sbjct: 780 GHRPHEGPGGSMGGGGGHRPH 800


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.134    0.426 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,861,203
Number of Sequences: 37866
Number of extensions: 3449685
Number of successful extensions: 29524
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 137
Number of HSP's successfully gapped in prelim test: 795
Number of HSP's that attempted gapping in prelim test: 21156
Number of HSP's gapped (non-prelim): 7217
length of query: 1128
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1015
effective length of database: 13,968,660
effective search space: 14178189900
effective search space used: 14178189900
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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