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Search of human proteins with 110735443
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110735443 delta-like 1 [Homo sapiens]
(723 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110735443 delta-like 1 [Homo sapiens] 1597 0.0
gi|9506545 delta-like 4 protein precursor [Homo sapiens] 707 0.0
gi|4557679 jagged 1 precursor [Homo sapiens] 504 e-142
gi|21704279 jagged 2 isoform b precursor [Homo sapiens] 489 e-138
gi|21704277 jagged 2 isoform a precursor [Homo sapiens] 481 e-136
gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens] 343 2e-94
gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens] 343 2e-94
gi|148833508 notch1 preproprotein [Homo sapiens] 285 1e-76
gi|24041035 notch 2 preproprotein [Homo sapiens] 271 2e-72
gi|134244285 Notch homolog 3 [Homo sapiens] 268 1e-71
gi|112420992 crumbs homolog 2 [Homo sapiens] 243 3e-64
gi|224451128 eyes shut homolog isoform 1 [Homo sapiens] 237 2e-62
gi|41327708 crumbs homolog 1 precursor [Homo sapiens] 236 4e-62
gi|148886654 polydom [Homo sapiens] 236 4e-62
gi|55770876 notch4 preproprotein [Homo sapiens] 230 4e-60
gi|188528675 slit homolog 1 [Homo sapiens] 226 7e-59
gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens] 225 1e-58
gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens] 225 1e-58
gi|116235485 delta-notch-like EGF repeat-containing transmembran... 224 2e-58
gi|74136023 delta-like 1 homolog [Homo sapiens] 224 2e-58
gi|122937283 6720455I24Rik homolog [Homo sapiens] 205 1e-52
gi|4759146 slit homolog 2 [Homo sapiens] 199 7e-51
gi|11321571 slit homolog 3 [Homo sapiens] 191 3e-48
gi|209571555 von Willebrand factor D and EGF domains [Homo sapiens] 164 3e-40
gi|181336739 multiple EGF-like-domains 11 [Homo sapiens] 159 1e-38
gi|126091152 cubilin [Homo sapiens] 155 1e-37
gi|224451131 eyes shut homolog isoform 2 [Homo sapiens] 155 2e-37
gi|38093661 eyes shut homolog isoform 3 [Homo sapiens] 155 2e-37
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 154 4e-37
gi|46397353 Notch homolog 2 N-terminal like protein [Homo sapiens] 152 8e-37
>gi|110735443 delta-like 1 [Homo sapiens]
Length = 723
Score = 1597 bits (4136), Expect = 0.0
Identities = 723/723 (100%), Positives = 723/723 (100%)
Query: 1 MGSRCALALAVLSALLCQVWSSGVFELKLQEFVNKKGLLGNRNCCRGGAGPPPCACRTFF 60
MGSRCALALAVLSALLCQVWSSGVFELKLQEFVNKKGLLGNRNCCRGGAGPPPCACRTFF
Sbjct: 1 MGSRCALALAVLSALLCQVWSSGVFELKLQEFVNKKGLLGNRNCCRGGAGPPPCACRTFF 60
Query: 61 RVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSLPDGGGADSAFSNPIRFPFGFTWPGTF 120
RVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSLPDGGGADSAFSNPIRFPFGFTWPGTF
Sbjct: 61 RVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSLPDGGGADSAFSNPIRFPFGFTWPGTF 120
Query: 121 SLIIEALHTDSPDDLATENPERLISRLATQRHLTVGEEWSQDLHSSGRTDLKYSYRFVCD 180
SLIIEALHTDSPDDLATENPERLISRLATQRHLTVGEEWSQDLHSSGRTDLKYSYRFVCD
Sbjct: 121 SLIIEALHTDSPDDLATENPERLISRLATQRHLTVGEEWSQDLHSSGRTDLKYSYRFVCD 180
Query: 181 EHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKP 240
EHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKP
Sbjct: 181 EHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKP 240
Query: 241 GECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKN 300
GECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKN
Sbjct: 241 GECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKN 300
Query: 301 GATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYG 360
GATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYG
Sbjct: 301 GATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYG 360
Query: 361 KICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKC 420
KICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKC
Sbjct: 361 KICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKC 420
Query: 421 VDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSA 480
VDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSA
Sbjct: 421 VDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSA 480
Query: 481 PVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVDLTEKLEGQG 540
PVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVDLTEKLEGQG
Sbjct: 481 PVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVDLTEKLEGQG 540
Query: 541 GPFPWVAVCAGVILVLMLLLGCAAVVVCVRLRLQKHRPPADPCRGETETMNNLANCQREK 600
GPFPWVAVCAGVILVLMLLLGCAAVVVCVRLRLQKHRPPADPCRGETETMNNLANCQREK
Sbjct: 541 GPFPWVAVCAGVILVLMLLLGCAAVVVCVRLRLQKHRPPADPCRGETETMNNLANCQREK 600
Query: 601 DISVSIIGATQIKNTNKKADFHGDHSADKNGFKARYPAVDYNLVQDLKGDDTAVRDAHSK 660
DISVSIIGATQIKNTNKKADFHGDHSADKNGFKARYPAVDYNLVQDLKGDDTAVRDAHSK
Sbjct: 601 DISVSIIGATQIKNTNKKADFHGDHSADKNGFKARYPAVDYNLVQDLKGDDTAVRDAHSK 660
Query: 661 RDTKCQPQGSSGEEKGTPTTLRGGEASERKRPDSGCSTSKDTKYQSVYVISEEKDECVIA 720
RDTKCQPQGSSGEEKGTPTTLRGGEASERKRPDSGCSTSKDTKYQSVYVISEEKDECVIA
Sbjct: 661 RDTKCQPQGSSGEEKGTPTTLRGGEASERKRPDSGCSTSKDTKYQSVYVISEEKDECVIA 720
Query: 721 TEV 723
TEV
Sbjct: 721 TEV 723
>gi|9506545 delta-like 4 protein precursor [Homo sapiens]
Length = 685
Score = 707 bits (1824), Expect = 0.0
Identities = 361/738 (48%), Positives = 460/738 (62%), Gaps = 74/738 (10%)
Query: 3 SRCALALAVLSALLCQVWS-----SGVFELKLQEFVNKKGLLGNRNCCRGGAGPPPCACR 57
SR A A+L LL +W SGVF+L+LQEF+N++G+L + C G CR
Sbjct: 5 SRSASGWALL--LLVALWQQRAAGSGVFQLQLQEFINERGVLASGRPCEPG-------CR 55
Query: 58 TFFRVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSLPD---GGGADSAFSNPIRFPFGF 114
TFFRVCLKH+QA VSP P CT+G+ TPVLG +SF++ D GGG NP++ PF F
Sbjct: 56 TFFRVCLKHFQAVVSPGP-CTFGTVSTPVLGTNSFAVRDDSSGGGR-----NPLQLPFNF 109
Query: 115 TWPGTFSLIIEALHTDSPDDLATEN--PERLISRLATQRHLTVGEEWSQDLHSSGRTDLK 172
TWPGTFSLIIEA H DDL E P+ LIS++A Q L VG+ W D +S T L+
Sbjct: 110 TWPGTFSLIIEAWHAPG-DDLRPEALPPDALISKIAIQGSLAVGQNWLLDEQTSTLTRLR 168
Query: 173 YSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDE 232
YSYR +C ++YYG+ CS C+ R+D FGH+ C G C PGW G YC +PICL GC E
Sbjct: 169 YSYRVICSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHE 228
Query: 233 QHGFCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYC 292
Q+G+C KP EC CR GWQGR C+ECI + GC HGTC PWQC C EGWGGLFC+QDLNYC
Sbjct: 229 QNGYCSKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYC 288
Query: 293 THHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSC 352
THH PCKNGATC+N+GQ SYTC+CRPGYTG CEL + ECD +PC+NGGSC D E+ Y C
Sbjct: 289 THHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHC 348
Query: 353 TCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDG-GYSCRCPVGYSGFNCEKKIDYCSS 411
CPPG+YG CE S ++CAD PCFNGG C + G Y+C CP ++G NCEKK+D C+S
Sbjct: 349 LCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTS 408
Query: 412 SPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPP 471
+PC+NG +C++ G + +CRC+ GF+G +C+ +V DCA +PCA+GGTC D N CTCP
Sbjct: 409 NPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPA 468
Query: 472 GYTGRNCS--APVSRCEHAPCHNGATCHE--RGHRYVCECARGYGGPNCQFLLPELPPGP 527
G++GR C + C +PC N ATC+ +VC C G+ G C+F + LPP
Sbjct: 469 GFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPV-GLPPS- 526
Query: 528 AVVDLTEKLEGQGGPFPWVAVCAGV-ILVLMLLLGCAAVVVCVRLRLQKHRPPADPCRGE 586
FPWVAV GV + VL++LLG AV V +LRL++ P G
Sbjct: 527 ---------------FPWVAVSLGVGLAVLLVLLGMVAVAV-RQLRLRR------PDDGS 564
Query: 587 TETMNNLANCQREKDISVSIIGATQIKNTNKKADFHGDHSADK-NGFKARYPAVDYNLVQ 645
E MNNL++ Q++ ++I A Q+KNTN+K + D DK N K + +DYNL
Sbjct: 565 REAMNNLSDFQKD-----NLIPAAQLKNTNQKKELEVDCGLDKSNCGKQQNHTLDYNLAP 619
Query: 646 DLKGDDTAVRDAHSKRDTKCQPQGSSGEEKGTPTTLRGGEASERKRPDSGCSTSKDTKYQ 705
G R T S + G LR R + CS +D+ YQ
Sbjct: 620 GPLG-----------RGTMPGKFPHSDKSLGEKAPLRLHSEKPECRISAICS-PRDSMYQ 667
Query: 706 SVYVISEEKDECVIATEV 723
SV +ISEE++ECVIATEV
Sbjct: 668 SVCLISEERNECVIATEV 685
>gi|4557679 jagged 1 precursor [Homo sapiens]
Length = 1218
Score = 504 bits (1297), Expect = e-142
Identities = 233/562 (41%), Positives = 310/562 (55%), Gaps = 53/562 (9%)
Query: 2 GSRCALALAVLSALLCQVW-SSGVFELKLQEFVNKKGLLGNRNCCRGGAGPPP--CA--- 55
G +L LA+L AL +V +SG FEL++ N G L N NCC G P C
Sbjct: 11 GRPLSLLLALLCALRAKVCGASGQFELEILSMQNVNGELQNGNCCGGARNPGDRKCTRDE 70
Query: 56 CRTFFRVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSLPDGGGADSAFSNPIRFPFGFT 115
C T+F+VCLK YQ+ V+ PC++GS TPV+G ++F+L G D N I PF F
Sbjct: 71 CDTYFKVCLKEYQSRVTAGGPCSFGSGSTPVIGGNTFNLKASRGNDR---NRIVLPFSFA 127
Query: 116 WPGTFSLIIEALHTDSPDDLATENPERLISRLATQRHLTVGEEWSQDLHSSGRTDLKYSY 175
WP +++L++EA DS +D T P+ +I + + + +W ++G +Y
Sbjct: 128 WPRSYTLLVEAW--DSSND--TVQPDSIIEKASHSGMINPSRQWQTLKQNTGVAHFEYQI 183
Query: 176 RFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHG 235
R CD++YYG GC+ FCRPRDD FGH+ C + G K C GW GP C IC GC +HG
Sbjct: 184 RVTCDDYYYGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHG 243
Query: 236 FCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHH 295
C PG+C+C+ GWQG YCD+CI +PGC+HG C +PWQC C+ WGG C++DLNYC H
Sbjct: 244 SCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTH 303
Query: 296 KPCKNGATCTNTGQGSYTCS--------------------------------------CR 317
+PC NG TC+NTG Y CS C
Sbjct: 304 QPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECS 363
Query: 318 PGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFN 377
PG+TG TC ID+C P+ C +GG+C DL N + C CPP + GK C+L A C PC N
Sbjct: 364 PGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVN 423
Query: 378 GGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSG 437
C + Y C C G+ G NC+ I+ C C N A C DL + Y C C G++G
Sbjct: 424 AKSCKNL-IASYYCDCLPGWMGQNCDININDCLGQ-CQNDASCRDLVNGYRCICPPGYAG 481
Query: 438 RHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCH 497
HC+ ++D+CAS+PC NGG C++ +N F C CP G++G C + CE PC NGA C+
Sbjct: 482 DHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCY 541
Query: 498 ERGHRYVCECARGYGGPNCQFL 519
R Y C+C Y G NC L
Sbjct: 542 NRASDYFCKCPEDYEGKNCSHL 563
Score = 241 bits (616), Expect = 1e-63
Identities = 135/426 (31%), Positives = 186/426 (43%), Gaps = 89/426 (20%)
Query: 175 YRFVCDEHYYGEGCSVFCRP--RDDAFGHFTCGERG---EKVCNPGWKGPYCTEPI--CL 227
Y+ C E Y G C + D +C E E C+PGW GP C+ I C
Sbjct: 320 YQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCS 379
Query: 228 PGCDEQHGFCD----------------------------KPGE-------------CKCR 246
P G C KP C C
Sbjct: 380 PNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCL 439
Query: 247 VGWQGRYCDECIRYPGCLHGTCQQP---------WQCNCQEGWGGLFCNQDLNYCTHHKP 297
GW G+ CD I CL G CQ ++C C G+ G C +D++ C + P
Sbjct: 440 PGWMGQNCD--ININDCL-GQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASN-P 495
Query: 298 CKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPG 357
C NG C N + C C G++G C+L ID C+P+PC+NG C + + Y C CP
Sbjct: 496 CLNGGHCQNE-INRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPED 554
Query: 358 FYGKICE-----------------LSAMTCADGP----------CFNGGRCSDSPDGGYS 390
+ GK C AM D P C G+C G ++
Sbjct: 555 YEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFT 614
Query: 391 CRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASS 450
C C G++G C + I+ C S+PC NG C+D ++Y C C G+ G +C+ N++DC+ +
Sbjct: 615 CDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQN 674
Query: 451 PCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARG 510
PC NGGTCRD VNDF C C G+ G+ C + S+C+ A C+NG TC++ G + C C G
Sbjct: 675 PCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGG 734
Query: 511 YGGPNC 516
+ G C
Sbjct: 735 WEGTTC 740
Score = 239 bits (611), Expect = 5e-63
Identities = 131/394 (33%), Positives = 182/394 (46%), Gaps = 49/394 (12%)
Query: 170 DLKYSYRFVCDEHYYGEGCSVF---CRPRDDAFGHFTCGE--RGEKVCNPGWKGPYCTEP 224
DL YR +C Y G+ C C G E R + +C G+ G C
Sbjct: 466 DLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLD 525
Query: 225 I--CLPGCDEQHGFCDKPGE---CKCRVGWQGRYC----DECIRYP-----GCL------ 264
I C P + C CKC ++G+ C D C P C
Sbjct: 526 IDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASN 585
Query: 265 ----------------HGTCQQP----WQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATC 304
HG C+ + C+C +G+ G +C++++N C + PC+NG TC
Sbjct: 586 DTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESN-PCRNGGTC 644
Query: 305 TNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICE 364
+ G SY C C G+ GA CE I++C +PC NGG+C DL N + C C G+ GK C
Sbjct: 645 ID-GVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCH 703
Query: 365 LSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCE-KKIDYCSSSPCSNGAKCVDL 423
C + C NGG C D D + C CP G+ G C + C +PC NG CV
Sbjct: 704 SRDSQCDEATCNNGGTCYDEGDA-FKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVN 762
Query: 424 GDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVS 483
G+++ C C+ G+ G C N +DC+ PC N GTC DG N + C C PG+ G +C ++
Sbjct: 763 GESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININ 822
Query: 484 RCEHAPCHNGATCHERGHRYVCECARGYGGPNCQ 517
C+ +PC GATC + + Y C C G+ G CQ
Sbjct: 823 ECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQ 856
Score = 223 bits (569), Expect = 4e-58
Identities = 133/457 (29%), Positives = 181/457 (39%), Gaps = 94/457 (20%)
Query: 164 HSSGRTDLKYSYRFVCDEHYYGEGCS-----------VFCRPRDDAFGHFTCGERGEKVC 212
H DL ++ VC + G+ C V + + + C C
Sbjct: 385 HGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCD------C 438
Query: 213 NPGWKGPYCTEPI--CLPGCDEQHGFCDKPG--ECKCRVGWQGRYC----DECIRYPGCL 264
PGW G C I CL C D C C G+ G +C DEC P
Sbjct: 439 LPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLN 498
Query: 265 HGTCQQP---WQCNCQEGWGGLFCNQDLNY------------------------------ 291
G CQ +QC C G+ G C D++Y
Sbjct: 499 GGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGK 558
Query: 292 -CTHHK------PCKNGATCT---------------------------NTGQGSYTCSCR 317
C+H K PC+ +CT + G +TC C
Sbjct: 559 NCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCN 618
Query: 318 PGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFN 377
G+TG C I++C+ +PC+NGG+C D NSY C C G+ G CE + C+ PC N
Sbjct: 619 KGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHN 678
Query: 378 GGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSG 437
GG C D + Y C C G+ G C + C + C+NG C D GDA+ C C G+ G
Sbjct: 679 GGTCRDLVNDFY-CDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEG 737
Query: 438 RHCD-DNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATC 496
C+ C +PC NGGTC F+C C G+ G C+ + C PC+N TC
Sbjct: 738 TTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTC 797
Query: 497 HERGHRYVCECARGYGGPNCQFLLPELPPGPAVVDLT 533
+ + Y CECA G+ GP+C+ + E P T
Sbjct: 798 VDGDNWYRCECAPGFAGPDCRININECQSSPCAFGAT 834
Score = 179 bits (453), Expect = 1e-44
Identities = 109/323 (33%), Positives = 147/323 (45%), Gaps = 31/323 (9%)
Query: 188 CSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPI--CLPGCDEQHGFCD---KPGE 242
C + + + G FTC CN G+ G YC E I C G C +
Sbjct: 599 CGPHGKCKSQSGGKFTCD------CNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYK 652
Query: 243 CKCRVGWQGRYCD----ECIRYPGCLHGTCQQ---PWQCNCQEGWGGLFCNQDLNYCTHH 295
C C GW+G YC+ +C + P GTC+ + C+C+ GW G C+ + C
Sbjct: 653 CICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDE- 711
Query: 296 KPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDE-CDPSPCKNGGSCTDLENSYSCTC 354
C NG TC + G ++ C C G+ G TC + + C P+PC NGG+C S++C C
Sbjct: 712 ATCNNGGTCYDEGD-AFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVC 770
Query: 355 PPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPC 414
G+ G IC + C+ PC+N G C D D Y C C G++G +C I+ C SSPC
Sbjct: 771 KEGWEGPICAQNTNDCSPHPCYNSGTCVDG-DNWYRCECAPGFAGPDCRININECQSSPC 829
Query: 415 SNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCAN-GGTCRDGVN-DFSCTCPPG 472
+ GA CVD + Y C C G SG C + + PC G DG D C
Sbjct: 830 AFGATCVDEINGYRCVCPPGHSGAKC----QEVSGRPCITMGSVIPDGAKWDDDCNTCQC 885
Query: 473 YTGRNCSAPVSRCEHAPC--HNG 493
GR + V C PC H G
Sbjct: 886 LNGRIACSKV-WCGPRPCLLHKG 907
Score = 156 bits (394), Expect = 7e-38
Identities = 97/294 (32%), Positives = 124/294 (42%), Gaps = 55/294 (18%)
Query: 211 VCNPGWKGPYCTEPI--CLPGCDEQHGFC-DKPGE--CKCRVGWQGRYCDECIRYPGCLH 265
+C+ GW+G YC I C G C D + C C+ GW+G+ C R C
Sbjct: 654 ICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHS--RDSQCDE 711
Query: 266 GTCQQ---------PWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSC 316
TC ++C C GW G CN N PC NG TC G+ S+TC C
Sbjct: 712 ATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGE-SFTCVC 770
Query: 317 RPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCF 376
+ G+ G C ++C P PC N G+C D +N Y C C PGF G C ++ C PC
Sbjct: 771 KEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCA 830
Query: 377 NGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPC-------SNGAKCVDLGDAYLC 429
G C D +G Y C CP G+SG C++ S PC +GAK D D C
Sbjct: 831 FGATCVDEING-YRCVCPPGHSGAKCQE----VSGRPCITMGSVIPDGAKWDD--DCNTC 883
Query: 430 RCQAGF-----------------------SGRHCDDNVDD-CASSPCANGGTCR 459
+C G SG+ C +DD C PC G CR
Sbjct: 884 QCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQCFVHPCTGVGECR 937
Score = 125 bits (315), Expect = 1e-28
Identities = 76/256 (29%), Positives = 107/256 (41%), Gaps = 22/256 (8%)
Query: 276 CQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPS 335
C + + G CN+ +C C G + C G+ G C I S
Sbjct: 187 CDDYYYGFGCNK---FCRPRDDFFGHYACDQNGNKT----CMEGWMGPECNRAICRQGCS 239
Query: 336 PCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPV 395
P GSC + C C G+ G C+ C P G C++ + C C
Sbjct: 240 P--KHGSC---KLPGDCRCQYGWQGLYCD----KCIPHPGCVHGICNEP----WQCLCET 286
Query: 396 GYSGFNCEKKIDYCSS-SPCSNGAKCVDLG-DAYLCRCQAGFSGRHCDDNVDDCASSPCA 453
+ G C+K ++YC + PC NG C + G D Y C C G+SG +C+ C S PC
Sbjct: 287 NWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCH 346
Query: 454 NGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGG 513
N G+C++ F C C PG+TG CS + C C +G TC + + + C C + G
Sbjct: 347 NRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTG 406
Query: 514 PNCQFLLPELPPGPAV 529
CQ E P V
Sbjct: 407 KTCQLDANECEAKPCV 422
>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
Length = 1200
Score = 489 bits (1260), Expect = e-138
Identities = 237/541 (43%), Positives = 295/541 (54%), Gaps = 29/541 (5%)
Query: 23 GVFELKLQEFVNKKGLLGNRNCCRG------GAGPPPCACRTFFRVCLKHYQASVSPEPP 76
G FEL+L N G L + CC G G C T+ RVCLK YQA V+P P
Sbjct: 28 GYFELQLSALRNVNGELLSGACCDGDGRTTRAGGCGHDECDTYVRVCLKEYQAKVTPTGP 87
Query: 77 CTYGSAVTPVLGVDSFSLPDGGGADSAFSNPIR-----------FPFGFTWPGTFSLIIE 125
C+YG TPVLG +SF LP G A R PF F WP +F+LI+E
Sbjct: 88 CSYGHGATPVLGGNSFYLPPAGAAGDRARARARAGGDQDPGLVVIPFQFAWPRSFTLIVE 147
Query: 126 ALHTDSPDDLATENPERLISRLATQRHLTVGEEWSQDLHSSGRT-DLKYSYRFVCDEHYY 184
A D+ T N E LI R++ + + W + LH SG L+ R CDE+YY
Sbjct: 148 AWDWDND---TTPNEELLIERVSHAGMINPEDRW-KSLHFSGHVAHLELQIRVRCDENYY 203
Query: 185 GEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKPGECK 244
C+ FCRPR+D FGH+TC + G K C GW G C E +C GC+ HG C PGEC+
Sbjct: 204 SATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECR 263
Query: 245 CRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATC 304
C GWQGR+CDEC+ YPGC+HG+C +PWQCNC+ WGGL C++DLNYC H PC NG TC
Sbjct: 264 CSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTC 323
Query: 305 TNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICE 364
N Y C+C GY+G CE C +PC NGGSC ++ + + C CP G+ G C
Sbjct: 324 INAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCA 383
Query: 365 LSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLG 424
L CA PC GG C D D G+ C CP + G C+ ++ C C +G C DL
Sbjct: 384 LDIDECASNPCAAGGTCVDQVD-GFECICPEQWVGATCQLDVNDCRGQ-CQHGGTCKDLV 441
Query: 425 DAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSR 484
+ Y C C GF GRHC+ D+CASSPC +GG C D + F C CP G++G C V
Sbjct: 442 NGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDL 501
Query: 485 CEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELP-PGPA--VVDLTEKLEGQGG 541
CE +PC NGA C+ Y C C +GG NC +P P PG A V+D G G
Sbjct: 502 CEPSPCRNGARCYNLEGDYYCACPDDFGGKNCS--VPREPCPGGACRVIDGCGSDAGPGM 559
Query: 542 P 542
P
Sbjct: 560 P 560
Score = 241 bits (616), Expect = 1e-63
Identities = 134/387 (34%), Positives = 173/387 (44%), Gaps = 53/387 (13%)
Query: 175 YRFVCDEHYYGEGCSVF---CRPRDDAFGHFTCGERG---EKVCNPGWKGPYCTEPI--- 225
YR C + Y G C C A G +C E E C GW GP C I
Sbjct: 331 YRCTCPDGYSGRNCEKAEHACTSNPCANGG-SCHEVPSGFECHCPSGWSGPTCALDIDEC 389
Query: 226 ----CLPG---CDEQHGFCDKPGECKCRVGWQGRYCDECIR--YPGCLHG-TCQQ---PW 272
C G D+ GF EC C W G C + C HG TC+ +
Sbjct: 390 ASNPCAAGGTCVDQVDGF-----ECICPEQWVGATCQLDVNDCRGQCQHGGTCKDLVNGY 444
Query: 273 QCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDEC 332
QC C G+GG C + + C PC +G C + G + C C G++G CE+ +D C
Sbjct: 445 QCVCPRGFGGRHCELERDECAS-SPCHSGGLCEDLADG-FHCHCPQGFSGPLCEVDVDLC 502
Query: 333 DPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTC---------------------- 370
+PSPC+NG C +LE Y C CP F GK C + C
Sbjct: 503 EPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGT 562
Query: 371 -ADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLC 429
A G C GRC P G +SC C G++G C + ID C PC NG C+D DA+ C
Sbjct: 563 AASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRC 622
Query: 430 RCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAP 489
C +G+ G CD N +DC PC + G C D VNDF C C G+ G+ C + +C+
Sbjct: 623 FCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYT 682
Query: 490 CHNGATCHERGHRYVCECARGYGGPNC 516
C NG TC++ G + C C G+ G C
Sbjct: 683 CSNGGTCYDSGDTFRCACPPGWKGSTC 709
Score = 225 bits (574), Expect = 1e-58
Identities = 140/447 (31%), Positives = 187/447 (41%), Gaps = 67/447 (14%)
Query: 153 LTVGEEWSQDLHSSGRTDLKYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERG---- 208
L V + Q H DL Y+ VC + G C + D C G
Sbjct: 422 LDVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCEL----ERDECASSPCHSGGLCED 477
Query: 209 -----EKVCNPGWKGPYCTEPI--CLPGCDEQHGFC-DKPGE--CKCRVGWQGRYCD--- 255
C G+ GP C + C P C + G+ C C + G+ C
Sbjct: 478 LADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPR 537
Query: 256 ------ECIRYPGC------------------LHGTC-QQP---WQCNCQEGWGGLFCNQ 287
C GC HG C QP + C C G+ G +C++
Sbjct: 538 EPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHE 597
Query: 288 DLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLE 347
+++ C +PC+NG TC + ++ C C G+ G C+ ++C P PC + G C DL
Sbjct: 598 NIDDCLG-QPCRNGGTCIDEVD-AFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLV 655
Query: 348 NSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCE-KKI 406
N + C C G+ GK C C C NGG C DS D + C CP G+ G C K
Sbjct: 656 NDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDT-FRCACPPGWKGSTCAVAKN 714
Query: 407 DYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFS 466
C +PC NG CV G ++ C C+ G+ GR C N +DC PC NGG C DGVN F
Sbjct: 715 SSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFR 774
Query: 467 CTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPG 526
C C PG+ G +C + C+ +PC GATC + + Y C C G GP CQ
Sbjct: 775 CECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQ--------- 825
Query: 527 PAVVDLTEKLEGQGGPFP----WVAVC 549
V+ +G PFP WV C
Sbjct: 826 -EVIGFGRSCWSRGTPFPHGSSWVEDC 851
>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
Length = 1238
Score = 481 bits (1239), Expect = e-136
Identities = 240/578 (41%), Positives = 296/578 (51%), Gaps = 65/578 (11%)
Query: 23 GVFELKLQEFVNKKGLLGNRNCCRG------GAGPPPCACRTFFRVCLKHYQASVSPEPP 76
G FEL+L N G L + CC G G C T+ RVCLK YQA V+P P
Sbjct: 28 GYFELQLSALRNVNGELLSGACCDGDGRTTRAGGCGHDECDTYVRVCLKEYQAKVTPTGP 87
Query: 77 CTYGSAVTPVLGVDSFSLPDGGGADSAFSNPIR-----------FPFGFTWPGTFSLIIE 125
C+YG TPVLG +SF LP G A R PF F WP +F+LI+E
Sbjct: 88 CSYGHGATPVLGGNSFYLPPAGAAGDRARARARAGGDQDPGLVVIPFQFAWPRSFTLIVE 147
Query: 126 ALHTDSPDDLATENPERLISRLATQRHLTVGEEWSQDLHSSGRT-DLKYSYRFVCDEHYY 184
A D+ T N E LI R++ + + W + LH SG L+ R CDE+YY
Sbjct: 148 AWDWDND---TTPNEELLIERVSHAGMINPEDRW-KSLHFSGHVAHLELQIRVRCDENYY 203
Query: 185 GEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKPGECK 244
C+ FCRPR+D FGH+TC + G K C GW G C E +C GC+ HG C PGEC+
Sbjct: 204 SATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECR 263
Query: 245 CRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATC 304
C GWQGR+CDEC+ YPGC+HG+C +PWQCNC+ WGGL C++DLNYC H PC NG TC
Sbjct: 264 CSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTC 323
Query: 305 TNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICE 364
N Y C+C GY+G CE C +PC NGGSC ++ + + C CP G+ G C
Sbjct: 324 INAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCA 383
Query: 365 LSAMTCADGPCFNGGRCSDSPD-------------------------------------G 387
L CA PC GG C D D G
Sbjct: 384 LDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIG 443
Query: 388 GYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDC 447
GY C C G+ G NC ++ C C +G C DL + Y C C GF GRHC+ D+C
Sbjct: 444 GYYCDCIPGWKGINCHINVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDEC 502
Query: 448 ASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCEC 507
ASSPC +GG C D + F C CP G++G C V CE +PC NGA C+ Y C C
Sbjct: 503 ASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCAC 562
Query: 508 ARGYGGPNCQFLLPELP-PGPA--VVDLTEKLEGQGGP 542
+GG NC +P P PG A V+D G G P
Sbjct: 563 PDDFGGKNCS--VPREPCPGGACRVIDGCGSDAGPGMP 598
Score = 232 bits (592), Expect = 8e-61
Identities = 137/422 (32%), Positives = 179/422 (42%), Gaps = 85/422 (20%)
Query: 175 YRFVCDEHYYGEGCSVF---CRPRDDAFGHFTCGERG---EKVCNPGWKGPYCTEPI--- 225
YR C + Y G C C A G +C E E C GW GP C I
Sbjct: 331 YRCTCPDGYSGRNCEKAEHACTSNPCANGG-SCHEVPSGFECHCPSGWSGPTCALDIDEC 389
Query: 226 ----CLPG---CDEQHGF-CDKPGE--------------------------------CKC 245
C G D+ GF C P + C C
Sbjct: 390 ASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDC 449
Query: 246 RVGWQGRYC----DECIRYPGCLHG-TCQQ---PWQCNCQEGWGGLFCNQDLNYCTHHKP 297
GW+G C ++C C HG TC+ +QC C G+GG C + + C P
Sbjct: 450 IPGWKGINCHINVNDCRGQ--CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECAS-SP 506
Query: 298 CKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPG 357
C +G C + G + C C G++G CE+ +D C+PSPC+NG C +LE Y C CP
Sbjct: 507 CHSGGLCEDLADG-FHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDD 565
Query: 358 FYGKICELSAMTC-----------------------ADGPCFNGGRCSDSPDGGYSCRCP 394
F GK C + C A G C GRC P G +SC C
Sbjct: 566 FGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICD 625
Query: 395 VGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCAN 454
G++G C + ID C PC NG C+D DA+ C C +G+ G CD N +DC PC +
Sbjct: 626 SGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHS 685
Query: 455 GGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGP 514
G C D VNDF C C G+ G+ C + +C+ C NG TC++ G + C C G+ G
Sbjct: 686 RGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGS 745
Query: 515 NC 516
C
Sbjct: 746 TC 747
Score = 228 bits (581), Expect = 2e-59
Identities = 140/448 (31%), Positives = 188/448 (41%), Gaps = 67/448 (14%)
Query: 152 HLTVGEEWSQDLHSSGRTDLKYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERG--- 208
H+ V + Q H DL Y+ VC + G C + D C G
Sbjct: 459 HINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCEL----ERDECASSPCHSGGLCE 514
Query: 209 ------EKVCNPGWKGPYCTEPI--CLPGCDEQHGFC-DKPGE--CKCRVGWQGRYCD-- 255
C G+ GP C + C P C + G+ C C + G+ C
Sbjct: 515 DLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVP 574
Query: 256 -------ECIRYPGC------------------LHGTC-QQP---WQCNCQEGWGGLFCN 286
C GC HG C QP + C C G+ G +C+
Sbjct: 575 REPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCH 634
Query: 287 QDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDL 346
++++ C +PC+NG TC + ++ C C G+ G C+ ++C P PC + G C DL
Sbjct: 635 ENIDDCLG-QPCRNGGTCIDEVD-AFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDL 692
Query: 347 ENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCE-KK 405
N + C C G+ GK C C C NGG C DS D + C CP G+ G C K
Sbjct: 693 VNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDT-FRCACPPGWKGSTCAVAK 751
Query: 406 IDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDF 465
C +PC NG CV G ++ C C+ G+ GR C N +DC PC NGG C DGVN F
Sbjct: 752 NSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWF 811
Query: 466 SCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPP 525
C C PG+ G +C + C+ +PC GATC + + Y C C G GP CQ
Sbjct: 812 RCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQ-------- 863
Query: 526 GPAVVDLTEKLEGQGGPFP----WVAVC 549
V+ +G PFP WV C
Sbjct: 864 --EVIGFGRSCWSRGTPFPHGSSWVEDC 889
>gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens]
Length = 618
Score = 343 bits (881), Expect = 2e-94
Identities = 209/585 (35%), Positives = 274/585 (46%), Gaps = 95/585 (16%)
Query: 7 LALAVLSAL--LCQVWSSGVFELKLQEFVNKKGLLGNRNCCRGGAGPPPCA----CRTFF 60
L+ V+ AL L Q +GVFEL++ F G GA PC+ CR FF
Sbjct: 10 LSQTVILALIFLPQTRPAGVFELQIHSFGPGPG---------PGAPRSPCSARLPCRLFF 60
Query: 61 RVCLKHYQASVSPEPPCTYGSAVT---------PVLGVDSFSLPDGGGADSAFSNPIRFP 111
RVCLK + + E PC G+A++ P LPDG ++ P
Sbjct: 61 RVCLKPGLSEEAAESPCALGAALSARGPVYTEQPGAPAPDLPLPDG---------LLQVP 111
Query: 112 FGFTWPGTFSLIIEALHTDSPDDLATENPERLISRLATQRHLTVGEEWSQDLHSSGRTDL 171
F WPGTFS IIE + D + L++R+A +R L G W++D+ +G +L
Sbjct: 112 FRDAWPGTFSFIIETWREELGDQIGGP-AWSLLARVAGRRRLAAGGPWARDIQRAGAWEL 170
Query: 172 KYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCD 231
++SYR C+ G C+ CRPR C PG + C P D
Sbjct: 171 RFSYRARCEPPAVGTACTRLCRPRS-----------APSRCGPGLRP-------CAPLED 212
Query: 232 EQHGFCDKPGECKCRVGWQGRYCDECIRYPGCL--HGTCQQPWQCNCQEGWGGLFCNQDL 289
E C+ P C+ GC HG C+QP +C C EGW G C
Sbjct: 213 E----CEAPLVCRA----------------GCSPEHGFCEQPGECRCLEGWTGPLCTV-- 250
Query: 290 NYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENS 349
P + + G S T C G CD +PC NGGSC++ S
Sbjct: 251 -------PVSTSSCLSPRGPSSATTGCLVPGPGP--------CDGNPCANGGSCSETPRS 295
Query: 350 YSCTCPPGFYGKICELSAMTCADGPCFNGGRC--SDSPDGGYSCRCPVGYSGFNCEKKID 407
+ CTCP GFYG CE+S +TCADGPCFNGG C PD Y C CP G+ G NCEK++D
Sbjct: 296 FECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVD 355
Query: 408 YCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSC 467
CS PC NG C+DLG A CRC+AGF+G C+ ++DDCA CANGGTC +G C
Sbjct: 356 RCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRC 415
Query: 468 TCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGP 527
+C G+ GR+C C PC +G C+ VC CA GY G C+F P P G
Sbjct: 416 SCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEF--PVHPDGA 473
Query: 528 AVVDLTEKLEGQGGPFPWVAVCAGVILVLMLLLGCAAVVVCVRLR 572
+ + G P ++ A +LV + G A ++V VR R
Sbjct: 474 SALPAAPPGLRPGDPQRYLLPPALGLLVAAGVAGAALLLVHVRRR 518
>gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens]
Length = 587
Score = 343 bits (881), Expect = 2e-94
Identities = 209/585 (35%), Positives = 274/585 (46%), Gaps = 95/585 (16%)
Query: 7 LALAVLSAL--LCQVWSSGVFELKLQEFVNKKGLLGNRNCCRGGAGPPPCA----CRTFF 60
L+ V+ AL L Q +GVFEL++ F G GA PC+ CR FF
Sbjct: 10 LSQTVILALIFLPQTRPAGVFELQIHSFGPGPG---------PGAPRSPCSARLPCRLFF 60
Query: 61 RVCLKHYQASVSPEPPCTYGSAVT---------PVLGVDSFSLPDGGGADSAFSNPIRFP 111
RVCLK + + E PC G+A++ P LPDG ++ P
Sbjct: 61 RVCLKPGLSEEAAESPCALGAALSARGPVYTEQPGAPAPDLPLPDG---------LLQVP 111
Query: 112 FGFTWPGTFSLIIEALHTDSPDDLATENPERLISRLATQRHLTVGEEWSQDLHSSGRTDL 171
F WPGTFS IIE + D + L++R+A +R L G W++D+ +G +L
Sbjct: 112 FRDAWPGTFSFIIETWREELGDQIGGP-AWSLLARVAGRRRLAAGGPWARDIQRAGAWEL 170
Query: 172 KYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCD 231
++SYR C+ G C+ CRPR C PG + C P D
Sbjct: 171 RFSYRARCEPPAVGTACTRLCRPRS-----------APSRCGPGLRP-------CAPLED 212
Query: 232 EQHGFCDKPGECKCRVGWQGRYCDECIRYPGCL--HGTCQQPWQCNCQEGWGGLFCNQDL 289
E C+ P C+ GC HG C+QP +C C EGW G C
Sbjct: 213 E----CEAPLVCRA----------------GCSPEHGFCEQPGECRCLEGWTGPLCTV-- 250
Query: 290 NYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENS 349
P + + G S T C G CD +PC NGGSC++ S
Sbjct: 251 -------PVSTSSCLSPRGPSSATTGCLVPGPGP--------CDGNPCANGGSCSETPRS 295
Query: 350 YSCTCPPGFYGKICELSAMTCADGPCFNGGRC--SDSPDGGYSCRCPVGYSGFNCEKKID 407
+ CTCP GFYG CE+S +TCADGPCFNGG C PD Y C CP G+ G NCEK++D
Sbjct: 296 FECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVD 355
Query: 408 YCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSC 467
CS PC NG C+DLG A CRC+AGF+G C+ ++DDCA CANGGTC +G C
Sbjct: 356 RCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRC 415
Query: 468 TCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGP 527
+C G+ GR+C C PC +G C+ VC CA GY G C+F P P G
Sbjct: 416 SCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEF--PVHPDGA 473
Query: 528 AVVDLTEKLEGQGGPFPWVAVCAGVILVLMLLLGCAAVVVCVRLR 572
+ + G P ++ A +LV + G A ++V VR R
Sbjct: 474 SALPAAPPGLRPGDPQRYLLPPALGLLVAAGVAGAALLLVHVRRR 518
>gi|148833508 notch1 preproprotein [Homo sapiens]
Length = 2555
Score = 285 bits (728), Expect = 1e-76
Identities = 155/408 (37%), Positives = 196/408 (48%), Gaps = 71/408 (17%)
Query: 175 YRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCT------EPICLP 228
Y C+ Y G C++ D+ G+ C G C G G C +P CL
Sbjct: 662 YECACEPGYTGSMCNINI---DECAGN-PCHNGG--TCEDGINGFTCRCPEGYHDPTCLS 715
Query: 229 GCDE------QHGFCDKP---GECKCRVGWQGRYCD----ECIRYPGCLHGTCQQP---W 272
+E HG C +C C GW G CD EC P GTC+ +
Sbjct: 716 EVNECNSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGY 775
Query: 273 QCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDEC 332
C C+EG+ G C ++N C + PC N TC + G Y C+C YTGATCE+ + C
Sbjct: 776 VCTCREGFSGPNCQTNINECASN-PCLNQGTCIDDVAG-YKCNCLLPYTGATCEVVLAPC 833
Query: 333 DPSPCKNGGSCTDLEN--SYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYS 390
PSPC+NGG C E+ S+SC CP G+ G+ CE+ C PC +G C ++ GGY
Sbjct: 834 APSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNT-HGGYR 892
Query: 391 CRCPVGYSGFNCEKKID--------------------------------------YCSSS 412
C C GYSG NCE ID C+S
Sbjct: 893 CHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASD 952
Query: 413 PCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPG 472
PC NGA C D D+Y C C AGFSG HC++N DC S C NGGTC DG+N F+C CPPG
Sbjct: 953 PCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPG 1012
Query: 473 YTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLL 520
+TG C V+ C+ PC +G TC + Y C C +GY GPNCQ L+
Sbjct: 1013 FTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLV 1060
Score = 281 bits (718), Expect = 2e-75
Identities = 146/374 (39%), Positives = 189/374 (50%), Gaps = 25/374 (6%)
Query: 163 LHSSGRTDLKYSYRFVCDEHYYGEGCSVF---CRPRDDAFGHFTCGERGEK---VCNPGW 216
+H + R L Y+ CD + G C + C G TC + C G+
Sbjct: 726 VHGACRDSLN-GYKCDCDPGWSGTNCDINNNECESNPCVNGG-TCKDMTSGYVCTCREGF 783
Query: 217 KGPYCTEPI--CLPGCDEQHGFC--DKPG-ECKCRVGWQGRYCD----ECIRYPGCLHGT 267
GP C I C G C D G +C C + + G C+ C P G
Sbjct: 784 SGPNCQTNINECASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGE 843
Query: 268 CQQP-----WQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTG 322
C+Q + C C GW G C D+N C PC++GA+C NT G Y C C+ GY+G
Sbjct: 844 CRQSEDYESFSCVCPTGWQGQTCEVDINECVL-SPCRHGASCQNT-HGGYRCHCQAGYSG 901
Query: 323 ATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCS 382
CE ID+C P+PC NGGSCTD N+ C C PGF G CE CA PC NG C+
Sbjct: 902 RNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCT 961
Query: 383 DSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDD 442
D D Y+C CP G+SG +CE C+ S C NG CVD +++ C C GF+G +C
Sbjct: 962 DCVDS-YTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQH 1020
Query: 443 NVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHR 502
+V++C S PC +GGTC+DG + CTCP GYTG NC V C+ +PC NG C + +
Sbjct: 1021 DVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQ 1080
Query: 503 YVCECARGYGGPNC 516
Y CEC G+ G C
Sbjct: 1081 YRCECPSGWTGLYC 1094
Score = 275 bits (702), Expect = 1e-73
Identities = 151/398 (37%), Positives = 197/398 (49%), Gaps = 68/398 (17%)
Query: 188 CSVFCRPRDDA------FGHFTCGERGEKVCNPGWKGPYCTEPI--CLPGCDEQHGFC-D 238
CS+ P + A G F C C G+ GP C + C+ + C D
Sbjct: 416 CSLGANPCEHAGKCINTLGSFECQ------CLQGYTGPRCEIDVNECVSNPCQNDATCLD 469
Query: 239 KPGE--CKCRVGWQGRYC----DECIRYPGCLH-GTCQQP---WQCNCQEGWGGLFCNQD 288
+ GE C C G++G +C DEC P CLH G C +QC C G+ G C D
Sbjct: 470 QIGEFQCICMPGYEGVHCEVNTDECASSP-CLHNGRCLDKINEFQCECPTGFTGHLCQYD 528
Query: 289 LNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLEN 348
++ C PCKNGA C + G +YTC C GYTG CE+ IDECDP PC + GSC D
Sbjct: 529 VDECAS-TPCKNGAKCLD-GPNTYTCVCTEGYTGTHCEVDIDECDPDPC-HYGSCKDGVA 585
Query: 349 SYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDY 408
+++C C PG+ G CE + C+ PC +GG C D D Y C C G +G NCE +D
Sbjct: 586 TFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDR-DNAYLCFCLKGTTGPNCEINLDD 644
Query: 409 CSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCT 468
C+SSPC +G C+D D Y C C+ G++G C+ N+D+CA +PC NGGTC DG+N F+C
Sbjct: 645 CASSPCDSGT-CLDKIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCR 703
Query: 469 CP-------------------------------------PGYTGRNCSAPVSRCEHAPCH 491
CP PG++G NC + CE PC
Sbjct: 704 CPEGYHDPTCLSEVNECNSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCV 763
Query: 492 NGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAV 529
NG TC + YVC C G+ GPNCQ + E P +
Sbjct: 764 NGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCL 801
Score = 273 bits (699), Expect = 3e-73
Identities = 147/413 (35%), Positives = 192/413 (46%), Gaps = 78/413 (18%)
Query: 192 CRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPI-------CLPG--CDEQHGFCDKPGE 242
CR +D + F+C VC GW+G C I C G C HG
Sbjct: 844 CRQSED-YESFSC------VCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGY----R 892
Query: 243 CKCRVGWQGRYC----DECIRYPGCLHGTCQQPWQ---CNCQEGWGGLFCNQDLNYCTHH 295
C C+ G+ GR C D+C P G+C C+C G+ G FC +D+N C
Sbjct: 893 CHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASD 952
Query: 296 KPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCP 355
PC+NGA CT+ SYTC+C G++G CE +C S C NGG+C D NS++C CP
Sbjct: 953 -PCRNGANCTDCVD-SYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCP 1010
Query: 356 PGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCS 415
PGF G C+ C PC +GG C D G Y C CP GY+G NC+ + +C SSPC
Sbjct: 1011 PGFTGSYCQHDVNECDSQPCLHGGTCQDGC-GSYRCTCPQGYTGPNCQNLVHWCDSSPCK 1069
Query: 416 NGAKC------------------------------------------------VDLGDAY 427
NG KC VD G+ +
Sbjct: 1070 NGGKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTH 1129
Query: 428 LCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEH 487
CRCQAG++G +C+D VD+C+ SPC NG TC D + +SC C GY G NCS + C
Sbjct: 1130 HCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLS 1189
Query: 488 APCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVDLTEKLEGQG 540
PC NG TC + + Y C C RG G +C+ + + P V + K G
Sbjct: 1190 HPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNG 1242
Score = 266 bits (679), Expect = 7e-71
Identities = 126/327 (38%), Positives = 170/327 (51%), Gaps = 16/327 (4%)
Query: 209 EKVCNPGWKGPYCTEPI--CLPGCDEQHGFCD---KPGECKCRVGWQGRYC----DECIR 259
E C PG+ G C I C G C+ C+C G+ C +EC
Sbjct: 663 ECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNS 722
Query: 260 YPGCLHGTCQQP---WQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSC 316
P C+HG C+ ++C+C GW G C+ + N C + PC NG TC + G Y C+C
Sbjct: 723 NP-CVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESN-PCVNGGTCKDMTSG-YVCTC 779
Query: 317 RPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCF 376
R G++G C+ I+EC +PC N G+C D Y C C + G CE+ CA PC
Sbjct: 780 REGFSGPNCQTNINECASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCR 839
Query: 377 NGGRCSDSPD-GGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGF 435
NGG C S D +SC CP G+ G CE I+ C SPC +GA C + Y C CQAG+
Sbjct: 840 NGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGY 899
Query: 436 SGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGAT 495
SGR+C+ ++DDC +PC NGG+C DG+N C C PG+ G C ++ C PC NGA
Sbjct: 900 SGRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGAN 959
Query: 496 CHERGHRYVCECARGYGGPNCQFLLPE 522
C + Y C C G+ G +C+ P+
Sbjct: 960 CTDCVDSYTCTCPAGFSGIHCENNTPD 986
Score = 250 bits (638), Expect = 4e-66
Identities = 128/370 (34%), Positives = 168/370 (45%), Gaps = 57/370 (15%)
Query: 212 CNPGWKGPYCTEPI----CLPGCDEQHGFCDKPG---ECKCRVGWQGRYCDECI---RYP 261
C P W G YCTE + +P + G C C C GW G C E I
Sbjct: 283 CPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASA 342
Query: 262 GCLHG-TCQQ---PWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATC-TNTGQGSYTCSC 316
C HG TC + C C G GL C+ LN PC G+ C TN G C+C
Sbjct: 343 ACFHGATCHDRVASFYCECPHGRTGLLCH--LNDACISNPCNEGSNCDTNPVNGKAICTC 400
Query: 317 RPGYTGATCELGIDECD--PSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGP 374
GYTG C +DEC +PC++ G C + S+ C C G+ G CE+ C P
Sbjct: 401 PSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNP 460
Query: 375 CFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAG 434
C N C D G + C C GY G +CE D C+SSPC + +C+D + + C C G
Sbjct: 461 CQNDATCLDQI-GEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTG 519
Query: 435 FSGRHCDDNVDDCASSPCANG-------------------------------------GT 457
F+G C +VD+CAS+PC NG G+
Sbjct: 520 FTGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGS 579
Query: 458 CRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQ 517
C+DGV F+C C PGYTG +C ++ C PC +G TC +R + Y+C C +G GPNC+
Sbjct: 580 CKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCE 639
Query: 518 FLLPELPPGP 527
L + P
Sbjct: 640 INLDDCASSP 649
Score = 247 bits (630), Expect = 3e-65
Identities = 138/379 (36%), Positives = 183/379 (48%), Gaps = 30/379 (7%)
Query: 174 SYRFVCDEHYYGEGCS---VFCRPRDDAFGHFTCGERG----EKVCNPGWKGPYCTEPIC 226
SYR VC + G C V C P G TC G E C PG+ G C E I
Sbjct: 201 SYRCVCRATHTGPNCERPYVPCSPSPCQNGG-TCRPTGDVTHECACLPGFTGQNCEENID 259
Query: 227 -LPGCDEQHGFCDKPG----ECKCRVGWQGRYC----DECIRYPGCLH--GTCQQP---W 272
PG + ++G G C+C W G+YC DEC P GTC +
Sbjct: 260 DCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGY 319
Query: 273 QCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDEC 332
C C GW G C+++++ C C +GATC + S+ C C G TG C L D C
Sbjct: 320 NCVCVNGWTGEDCSENIDDCAS-AACFHGATCHDR-VASFYCECPHGRTGLLCHLN-DAC 376
Query: 333 DPSPCKNGGSC--TDLENSYSCTCPPGFYGKICELSAMTCADG--PCFNGGRCSDSPDGG 388
+PC G +C + CTCP G+ G C C+ G PC + G+C ++ G
Sbjct: 377 ISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTL-GS 435
Query: 389 YSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCA 448
+ C+C GY+G CE ++ C S+PC N A C+D + C C G+ G HC+ N D+CA
Sbjct: 436 FECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECA 495
Query: 449 SSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECA 508
SSPC + G C D +N+F C CP G+TG C V C PC NGA C + + Y C C
Sbjct: 496 SSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCT 555
Query: 509 RGYGGPNCQFLLPELPPGP 527
GY G +C+ + E P P
Sbjct: 556 EGYTGTHCEVDIDECDPDP 574
Score = 246 bits (629), Expect = 4e-65
Identities = 141/436 (32%), Positives = 186/436 (42%), Gaps = 86/436 (19%)
Query: 164 HSSGRTDLKYSYRFVCDEHYYGEGCSVF---CRPRDDAFGHFTCGERGEKVCN--PGWKG 218
H + + YR C Y G C CRP G C+ PG++G
Sbjct: 880 HGASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRG 939
Query: 219 PYCTEPI-------CLPGCDEQHGFCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQ- 270
+C E I C G + C C C G+ G +C+ P C +C
Sbjct: 940 TFCEEDINECASDPCRNGANCTD--CVDSYTCTCPAGFSGIHCEN--NTPDCTESSCFNG 995
Query: 271 --------PWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTG 322
+ C C G+ G +C D+N C +PC +G TC + G GSY C+C GYTG
Sbjct: 996 GTCVDGINSFTCLCPPGFTGSYCQHDVNECDS-QPCLHGGTCQD-GCGSYRCTCPQGYTG 1053
Query: 323 ATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTC------------ 370
C+ + CD SPCKNGG C Y C CP G+ G C++ +++C
Sbjct: 1054 PNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVA 1113
Query: 371 ------------------------------------ADGPCFNGGRCSDSPDGGYSCRCP 394
+ PC NG C+D GGYSC+C
Sbjct: 1114 RLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYL-GGYSCKCV 1172
Query: 395 VGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDC------- 447
GY G NC ++ID C S PC NG C+DL + Y C C G G HC+ NVDDC
Sbjct: 1173 AGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPV 1232
Query: 448 -ASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGAT--CHERGHRYV 504
S C N GTC D V +SCTCPPG+ G C V+ C PC T C +R + +
Sbjct: 1233 SRSPKCFNNGTCVDQVGGYSCTCPPGFVGERCEGDVNECLSNPCDARGTQNCVQRVNDFH 1292
Query: 505 CECARGYGGPNCQFLL 520
CEC G+ G C+ ++
Sbjct: 1293 CECRAGHTGRRCESVI 1308
Score = 233 bits (594), Expect = 5e-61
Identities = 118/326 (36%), Positives = 158/326 (48%), Gaps = 39/326 (11%)
Query: 217 KGPYCTEP--ICLPGCDEQHGFCDKPGECKCRVGWQGRYC------------DECIRYPG 262
+GP C++P CL G G+C+ G + C + C+ P
Sbjct: 20 RGPRCSQPGETCLNG-----------GKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPC 68
Query: 263 CLHGTCQ-------QPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCS 315
GTC + C+C G+ G C L+ PC+NG TC Y C
Sbjct: 69 KNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCR 128
Query: 316 CRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGP- 374
C PG++G +C+ D C +PC NGG C E SY C CPP F+G C C P
Sbjct: 129 CPPGWSGKSCQQA-DPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPG 187
Query: 375 -CFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGD-AYLCRCQ 432
C +GG C + G Y C C ++G NCE+ CS SPC NG C GD + C C
Sbjct: 188 LCRHGGTCHNEV-GSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACL 246
Query: 433 AGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAP--C 490
GF+G++C++N+DDC + C NGG C DGVN ++C CPP +TG+ C+ V C+ P C
Sbjct: 247 PGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNAC 306
Query: 491 HNGATCHERGHRYVCECARGYGGPNC 516
NG TCH Y C C G+ G +C
Sbjct: 307 QNGGTCHNTHGGYNCVCVNGWTGEDC 332
Score = 231 bits (589), Expect = 2e-60
Identities = 119/327 (36%), Positives = 164/327 (50%), Gaps = 24/327 (7%)
Query: 211 VCNPGWKGPYCTEPI-CLPGCDEQHGFC---DKPG----ECKCRVGWQGRYC-----DEC 257
VC + GP C +P CL + G C D+ G C C +G+ G C + C
Sbjct: 47 VCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNAC 106
Query: 258 IRYPGCLHGTCQ----QPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYT 313
+ P GTC ++C C GW G C Q + C + PC NG C + SY
Sbjct: 107 LTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQ-ADPCASN-PCANGGQCLPF-EASYI 163
Query: 314 CSCRPGYTGATCELGIDECDPSP--CKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCA 371
C C P + G TC ++EC P C++GG+C + SY C C G CE + C+
Sbjct: 164 CHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCS 223
Query: 372 DGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRC 431
PC NGG C + D + C C G++G NCE+ ID C + C NG CVD + Y CRC
Sbjct: 224 PSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRC 283
Query: 432 QAGFSGRHCDDNVDDCASSP--CANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAP 489
++G++C ++VD+C P C NGGTC + ++C C G+TG +CS + C A
Sbjct: 284 PPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAA 343
Query: 490 CHNGATCHERGHRYVCECARGYGGPNC 516
C +GATCH+R + CEC G G C
Sbjct: 344 CFHGATCHDRVASFYCECPHGRTGLLC 370
Score = 227 bits (579), Expect = 3e-59
Identities = 131/380 (34%), Positives = 175/380 (46%), Gaps = 60/380 (15%)
Query: 212 CNPGWKGPYCTEPI---CLPGCDEQHGFCD----KPGECKCRVGWQGRYC---DECIRYP 261
C G+ GP C P+ CL G CD +C+C GW G+ C D C P
Sbjct: 89 CALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCASNP 148
Query: 262 GCLHGTC---QQPWQCNCQEGWGGLFCNQDLNYC-------------------------- 292
G C + + C+C + G C QD+N C
Sbjct: 149 CANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRCVCRA 208
Query: 293 THH-------------KPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKN 339
TH PC+NG TC TG ++ C+C PG+TG CE ID+C + CKN
Sbjct: 209 THTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKN 268
Query: 340 GGSCTDLENSYSCTCPPGFYGKICELSAMTCADGP--CFNGGRCSDSPDGGYSCRCPVGY 397
GG+C D N+Y+C CPP + G+ C C P C NGG C ++ GGY+C C G+
Sbjct: 269 GGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNT-HGGYNCVCVNGW 327
Query: 398 SGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGT 457
+G +C + ID C+S+ C +GA C D ++ C C G +G C N D C S+PC G
Sbjct: 328 TGEDCSENIDDCASAACFHGATCHDRVASFYCECPHGRTGLLCHLN-DACISNPCNEGSN 386
Query: 458 C-RDGVNDFS-CTCPPGYTGRNCSAPVSRCEHA--PCHNGATCHERGHRYVCECARGYGG 513
C + VN + CTCP GYTG CS V C PC + C + C+C +GY G
Sbjct: 387 CDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTG 446
Query: 514 PNCQFLLPELPPGPAVVDLT 533
P C+ + E P D T
Sbjct: 447 PRCEIDVNECVSNPCQNDAT 466
Score = 214 bits (546), Expect = 2e-55
Identities = 136/406 (33%), Positives = 176/406 (43%), Gaps = 57/406 (14%)
Query: 163 LHSSGRTDLKYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEK---------VCN 213
LH D SYR C + Y G C D + C G+ C
Sbjct: 1031 LHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSS----PCKNGGKCWQTHTQYRCECP 1086
Query: 214 PGWKGPYCTEPICL-------PGCDE----QHG-FCDKPGE---CKCRVGWQGRYC---- 254
GW G YC P G D QHG C G C+C+ G+ G YC
Sbjct: 1087 SGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLV 1146
Query: 255 DECIRYPGCLHG-TCQQ---PWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQG 310
DEC P C +G TC + C C G+ G+ C+++++ C H PC+NG TC +
Sbjct: 1147 DECSPSP-CQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSH-PCQNGGTCLDL-PN 1203
Query: 311 SYTCSCRPGYTGATCELGIDECDP-------SP-CKNGGSCTDLENSYSCTCPPGFYGKI 362
+Y CSC G G CE+ +D+C+P SP C N G+C D YSCTCPPGF G+
Sbjct: 1204 TYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGER 1263
Query: 363 CELSAMTCADGPCFNGG--RCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKC 420
CE C PC G C + + C C G++G CE I+ C PC NG C
Sbjct: 1264 CEGDVNECLSNPCDARGTQNCVQRVND-FHCECRAGHTGRRCESVINGCKGKPCKNGGTC 1322
Query: 421 V---DLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRN 477
+ ++C+C AGF G C+++ C S C NGGTC G +C C +TG
Sbjct: 1323 AVASNTARGFICKCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGPFTGPE 1382
Query: 478 CSAPVSR--CEHAPCHNGATCHERGHR--YVCECARGYGGPNCQFL 519
C P S PC+N TC Y C C + G C L
Sbjct: 1383 CQFPASSPCLGGNPCYNQGTCEPTSESPFYRCLCPAKFNGLLCHIL 1428
Score = 140 bits (354), Expect = 3e-33
Identities = 75/199 (37%), Positives = 95/199 (47%), Gaps = 11/199 (5%)
Query: 337 CKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGG---YSCRC 393
C NGG C + +C C F G C+ C PC N G C G Y+C C
Sbjct: 31 CLNGGKCEAANGTEACVCGGAFVGPRCQ-DPNPCLSTPCKNAGTCHVVDRRGVADYACSC 89
Query: 394 PVGYSGFNCEKKIDY-CSSSPCSNGAKCVDLG-DAYLCRCQAGFSGRHCDDNVDDCASSP 451
+G+SG C +D C ++PC NG C L Y CRC G+SG+ C D CAS+P
Sbjct: 90 ALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQ-ADPCASNP 148
Query: 452 CANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAP--CHNGATCHERGHRYVCECAR 509
CANGG C + C CPP + G C V+ C P C +G TCH Y C C
Sbjct: 149 CANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRCVCRA 208
Query: 510 GYGGPNCQFLLPELPPGPA 528
+ GPNC+ P +P P+
Sbjct: 209 THTGPNCE--RPYVPCSPS 225
>gi|24041035 notch 2 preproprotein [Homo sapiens]
Length = 2471
Score = 271 bits (692), Expect = 2e-72
Identities = 141/363 (38%), Positives = 184/363 (50%), Gaps = 19/363 (5%)
Query: 175 YRFVCDEHYYGEGCSVF---CRPRDDAFGHFTCGERGEK-VCNPGWKGPYCT--EPICLP 228
+R +C E + C C G+ T G G K +C+ GW G C + CL
Sbjct: 704 FRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLS 763
Query: 229 GCDEQHGFCDK---PGECKCRVGWQGRYC----DECIRYPGCLHGTCQQP---WQCNCQE 278
+ G CD C C+ G++G C DEC P GTC + C+C
Sbjct: 764 NPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVL 823
Query: 279 GWGGLFCNQDLNYCTHHKPCKNGATCTNTGQ-GSYTCSCRPGYTGATCELGIDECDPSPC 337
+ G C L C+ + PC+N A C + SYTC C PG+ G C + IDEC PC
Sbjct: 824 PYTGKNCQTVLAPCSPN-PCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPC 882
Query: 338 KNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGY 397
N G C + + SY C CPPGF G CE C PC NGG C D + +SC C G+
Sbjct: 883 MNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNT-FSCLCLPGF 941
Query: 398 SGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGT 457
+G C+ ++ C S PC NG C D ++Y C+CQAGF G HC++N+++C S C NGGT
Sbjct: 942 TGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGT 1001
Query: 458 CRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQ 517
C DG+N FSC CP G+TG C ++ C PC N TC + Y C C GY G NCQ
Sbjct: 1002 CVDGINSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQ 1061
Query: 518 FLL 520
L+
Sbjct: 1062 TLV 1064
Score = 257 bits (656), Expect = 3e-68
Identities = 135/403 (33%), Positives = 189/403 (46%), Gaps = 69/403 (17%)
Query: 199 FGHFTCGERGEKVCNPGWKGPYCTEPI--CLPGCDEQHGFCDKPGE---CKCRVGWQGRY 253
F +TC +C PGW+G CT I C+ HG C C+C G+ G
Sbjct: 854 FESYTC------LCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMD 907
Query: 254 C----DECIRYPGCLHGTCQQ---PWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTN 306
C D+C+ P G+C + C C G+ G C D+N C +PCKNG TC++
Sbjct: 908 CEEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLS-EPCKNGGTCSD 966
Query: 307 TGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELS 366
SYTC C+ G+ G CE I+EC S C NGG+C D NS+SC CP GF G C
Sbjct: 967 Y-VNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHE 1025
Query: 367 AMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCV----- 421
C+ PC N G C D G Y C CP+GY+G NC+ ++ CS SPC N CV
Sbjct: 1026 INECSSHPCLNEGTCVDGL-GTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAE 1084
Query: 422 -------------------------------------------DLGDAYLCRCQAGFSGR 438
+ G+ + C+C G++G
Sbjct: 1085 SQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYTGS 1144
Query: 439 HCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHE 498
+C++ +D+CAS+PC +G TC D + + C C PGY G NC V C++ PC NG TC +
Sbjct: 1145 YCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCID 1204
Query: 499 RGHRYVCECARGYGGPNCQFLLPELPPGPAVVDLTEKLEGQGG 541
+ + C C G G C+ + + GP ++ + ++ GG
Sbjct: 1205 LVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGG 1247
Score = 246 bits (629), Expect = 4e-65
Identities = 137/390 (35%), Positives = 182/390 (46%), Gaps = 70/390 (17%)
Query: 197 DAFGHFTCGERGEKVCNPGWKGPYCTEPI--CLPGCDEQHGFCDKP---GECKCRVGWQG 251
D G + C C G+ G C + C + G C + +C C GW G
Sbjct: 1042 DGLGTYRCS------CPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAG 1095
Query: 252 RYCD--------ECIRYPGCLHGTCQQPW---------QCNCQEGWGGLFCNQDLNYCTH 294
YCD R + CQ C C G+ G +C + L+ C
Sbjct: 1096 AYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYTGSYCEEQLDECAS 1155
Query: 295 HKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTC 354
+ PC++GATC++ G Y C C PGY G CE +DEC PC+NGG+C DL N + C+C
Sbjct: 1156 N-PCQHGATCSDF-IGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSC 1213
Query: 355 PPGFYGKICELSAMTCADGP-CFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSP 413
PPG G +CE + CA GP C NGG+C D GGYSCRC G++G CE I+ C S+P
Sbjct: 1214 PPGTRGLLCEENIDDCARGPHCLNGGQCMDRI-GGYSCRCLPGFAGERCEGDINECLSNP 1272
Query: 414 CSNGAK--CVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVN---DFSCT 468
CS+ C+ L + YLC C++ F+GRHC+ VD C PC NGGTC N F C
Sbjct: 1273 CSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICR 1332
Query: 469 CPPGYTGRNCSAPV-----------------------------SRCEHAPCHNGATCHER 499
CPPG++G C + S C +PC +G +CH +
Sbjct: 1333 CPPGFSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASSPCQHGGSCHPQ 1392
Query: 500 GH--RYVCECARGYGGPNCQFLL--PELPP 525
Y C+CA + G C+ P PP
Sbjct: 1393 RQPPYYSCQCAPPFSGSRCELYTAPPSTPP 1422
Score = 243 bits (619), Expect = 6e-64
Identities = 124/344 (36%), Positives = 174/344 (50%), Gaps = 32/344 (9%)
Query: 197 DAFGHFTCGERGEKVCNPGWKGPYCTEPI--CLPGCDEQHGFCD---KPGECKCRVGWQG 251
D F+C +C PG+ G C + CL + G C CKC+ G+ G
Sbjct: 928 DGVNTFSC------LCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDG 981
Query: 252 RYCD----ECIRYPGCLHGTCQQ---PWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATC 304
+C+ EC GTC + C C G+ G FC ++N C+ H PC N TC
Sbjct: 982 VHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECSSH-PCLNEGTC 1040
Query: 305 TNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICE 364
+ G G+Y CSC GYTG C+ ++ C SPCKN G+C + C CP G+ G C+
Sbjct: 1041 VD-GLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCD 1099
Query: 365 LSAMTC----------ADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPC 414
+ ++C + C + G C ++ + Y C+CP+GY+G CE+++D C+S+PC
Sbjct: 1100 VPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHY-CQCPLGYTGSYCEEQLDECASNPC 1158
Query: 415 SNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYT 474
+GA C D Y C C G+ G +C+ VD+C + PC NGGTC D VN F C+CPPG
Sbjct: 1159 QHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTR 1218
Query: 475 GRNCSAPVSRCEHAP-CHNGATCHERGHRYVCECARGYGGPNCQ 517
G C + C P C NG C +R Y C C G+ G C+
Sbjct: 1219 GLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCE 1262
Score = 240 bits (612), Expect = 4e-63
Identities = 134/390 (34%), Positives = 182/390 (46%), Gaps = 31/390 (7%)
Query: 164 HSSGRTDLKYSYRFVCDEHYYGEGCS---VFCRPRDDAFGHFTCGERGEKV----CNPGW 216
H +L SY+ C + + G+ C V C P G TC + G+ C PG+
Sbjct: 194 HGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSPCVNGG-TCRQTGDFTFECNCLPGF 252
Query: 217 KGPYCTEPI--CLPGCDEQHGFCD---KPGECKCRVGWQGRYC----DECIRYPGCLH-- 265
+G C I C + G C C+C W G++C DEC+ P
Sbjct: 253 EGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNG 312
Query: 266 GTCQQP---WQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTG 322
GTC + C C GW G C+++++ C C G+TC + S++C C G G
Sbjct: 313 GTCANRNGGYGCVCVNGWSGDDCSENIDDCAFAS-CTPGSTCIDR-VASFSCMCPEGKAG 370
Query: 323 ATCELGIDECDPSPCKNGGSC--TDLENSYSCTCPPGFYGKICELSAMTCA---DGPCFN 377
C L D C +PC G C L Y CTCP G+ G C CA PC +
Sbjct: 371 LLCHLD-DACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEH 429
Query: 378 GGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSG 437
G+C ++ DG + C C GY+G CE I+ C S PC N A C+D + C C GF G
Sbjct: 430 AGKCVNT-DGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKG 488
Query: 438 RHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCH 497
HC+ +++C S+PC N G C D VN F C CPPG+TG C + C PC NGA C
Sbjct: 489 VHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCI 548
Query: 498 ERGHRYVCECARGYGGPNCQFLLPELPPGP 527
+ + Y C+CA G+ G C+ + P P
Sbjct: 549 DHPNGYECQCATGFTGVLCEENIDNCDPDP 578
Score = 239 bits (611), Expect = 5e-63
Identities = 139/434 (32%), Positives = 196/434 (45%), Gaps = 65/434 (14%)
Query: 155 VGEEWSQDLHSSGRT-DLKYSYRFVCDEHYYGEGCSV-FCRPRDDAFGHFTCGE---RGE 209
+ E +S + GR DL Y+ C G C + F + H C + R
Sbjct: 608 IDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGICMDGINRYS 667
Query: 210 KVCNPGWKGPYCTEPI-------CLPGCDEQHGFCDKPGECKCRVGWQGRYC----DECI 258
VC+PG+ G C I C G +G C C G C +EC+
Sbjct: 668 CVCSPGFTGQRCNIDIDECASNPCRKGATCINGV--NGFRCICPEGPHHPSCYSQVNECL 725
Query: 259 RYPGCLHGTCQ---QPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCS 315
P C+HG C ++C C GW G+ C D N C + PC+NG TC N G Y C+
Sbjct: 726 SNP-CIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSN-PCQNGGTCDNLVNG-YRCT 782
Query: 316 CRPGYTGATCELGIDECDPSPCKNGGSCTD-----------------------------L 346
C+ G+ G C++ IDEC +PC N G+C D
Sbjct: 783 CKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPC 842
Query: 347 EN-----------SYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPV 395
EN SY+C C PG+ G+ C + C PC N G C ++ G Y C CP
Sbjct: 843 ENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNT-QGSYMCECPP 901
Query: 396 GYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANG 455
G+SG +CE+ ID C ++PC NG C+D + + C C GF+G C ++++C S PC NG
Sbjct: 902 GFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNG 961
Query: 456 GTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPN 515
GTC D VN ++C C G+ G +C ++ C + C NG TC + + + C C G+ G
Sbjct: 962 GTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSF 1021
Query: 516 CQFLLPELPPGPAV 529
C + E P +
Sbjct: 1022 CLHEINECSSHPCL 1035
Score = 236 bits (603), Expect = 4e-62
Identities = 124/338 (36%), Positives = 167/338 (49%), Gaps = 22/338 (6%)
Query: 212 CNPGWKGPYCTEPI--CL--PGCDEQHGFCDKPGE---CKCRVGWQGRYCDECI---RYP 261
C P W G +CTE + CL P + G C C C GW G C E I +
Sbjct: 286 CPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFA 345
Query: 262 GCLHG-TCQQ---PWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATC-TNTGQGSYTCSC 316
C G TC + C C EG GL C+ D + C + PC GA C TN G Y C+C
Sbjct: 346 SCTPGSTCIDRVASFSCMCPEGKAGLLCHLD-DACISN-PCHKGALCDTNPLNGQYICTC 403
Query: 317 RPGYTGATCELGIDEC---DPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADG 373
GY GA C +DEC + +PC++ G C + + ++ C C G+ G CE+ C
Sbjct: 404 PQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSD 463
Query: 374 PCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQA 433
PC N C D GG++C C G+ G +CE +I+ C S+PC N +CVD + + C C
Sbjct: 464 PCQNDATCLDKI-GGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPP 522
Query: 434 GFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNG 493
GF+G C ++DDC+S+PC NG C D N + C C G+TG C + C+ PCH+G
Sbjct: 523 GFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHG 582
Query: 494 ATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVD 531
C + Y C C GY G C + E P + D
Sbjct: 583 -QCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLND 619
Score = 236 bits (602), Expect = 6e-62
Identities = 137/385 (35%), Positives = 178/385 (46%), Gaps = 70/385 (18%)
Query: 197 DAFGHFTCGERGEKVCNPGWKGPYCTEPI--CLPGCDEQHGFC-DKPG--ECKCRVGWQG 251
D G FTC +C PG+KG +C I C +G C DK +C C G+ G
Sbjct: 473 DKIGGFTC------LCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTG 526
Query: 252 RYC----DECIRYPGCLHGT--CQQP--WQCNCQEGWGGLFCNQDLNYCT----HHKPCK 299
C D+C P CL+G P ++C C G+ G+ C ++++ C HH C+
Sbjct: 527 PVCQIDIDDCSSTP-CLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQ 585
Query: 300 NGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFY 359
+G SYTC C PGY GA C IDEC SPC N G C DL N Y C C PG
Sbjct: 586 DGID-------SYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTS 638
Query: 360 GKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAK 419
G CE++ CA PC + G C D + YSC C G++G C ID C+S+PC GA
Sbjct: 639 GVNCEINFDDCASNPCIH-GICMDGIN-RYSCVCSPGFTGQRCNIDIDECASNPCRKGAT 696
Query: 420 CVD-----------------------------------LG--DAYLCRCQAGFSGRHCDD 442
C++ G Y C C AG+ G +C+
Sbjct: 697 CINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCEV 756
Query: 443 NVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHR 502
+ ++C S+PC NGGTC + VN + CTC G+ G NC + C PC N TC +
Sbjct: 757 DKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISG 816
Query: 503 YVCECARGYGGPNCQFLLPELPPGP 527
Y C C Y G NCQ +L P P
Sbjct: 817 YTCHCVLPYTGKNCQTVLAPCSPNP 841
Score = 232 bits (591), Expect = 1e-60
Identities = 119/324 (36%), Positives = 164/324 (50%), Gaps = 22/324 (6%)
Query: 212 CNPGWKGPYCTE-PICLPGCDEQHGFCDKPG-----ECKCRVGWQGRYCDECIRYP---- 261
C G+ G YC C + G C C+C G+ G C +P
Sbjct: 53 CPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVS 112
Query: 262 -GCLHG-TC----QQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCS 315
CL+G TC + ++C CQ G+ G C Q + C H PC NG+TCT T ++C
Sbjct: 113 RPCLNGGTCHMLSRDTYECTCQVGFTGKEC-QWTDACLSH-PCANGSTCT-TVANQFSCK 169
Query: 316 CRPGYTGATCELGIDECD-PSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGP 374
C G+TG CE ++ECD P C++GG+C +L SY C CP GF G+ C+ + CA P
Sbjct: 170 CLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSP 229
Query: 375 CFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAG 434
C NGG C + D + C C G+ G CE+ ID C + C NG CVD + Y CRC
Sbjct: 230 CVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQ 289
Query: 435 FSGRHCDDNVDDCASSP--CANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHN 492
++G+ C ++VD+C P C NGGTC + + C C G++G +CS + C A C
Sbjct: 290 WTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTP 349
Query: 493 GATCHERGHRYVCECARGYGGPNC 516
G+TC +R + C C G G C
Sbjct: 350 GSTCIDRVASFSCMCPEGKAGLLC 373
Score = 231 bits (590), Expect = 1e-60
Identities = 119/318 (37%), Positives = 159/318 (50%), Gaps = 23/318 (7%)
Query: 212 CNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYC---DECIRYPGCLHGTC 268
C G++ P E +C+ + + G CKC G+ G YC D C + GTC
Sbjct: 28 CRDGYE-PCVNEGMCVT-------YHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTC 79
Query: 269 QQPWQ-----CNCQEGWGGLFCNQDLNY-CTHHKPCKNGATCTNTGQGSYTCSCRPGYTG 322
C C G+ G C ++ C +PC NG TC + +Y C+C+ G+TG
Sbjct: 80 VAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTG 139
Query: 323 ATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTC-ADGPCFNGGRC 381
C+ D C PC NG +CT + N +SC C GF G+ CE C G C +GG C
Sbjct: 140 KECQ-WTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTC 198
Query: 382 SDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGD-AYLCRCQAGFSGRHC 440
+ P G Y C+CP G++G C+ C+ SPC NG C GD + C C GF G C
Sbjct: 199 LNLP-GSYQCQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTC 257
Query: 441 DDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAP--CHNGATCHE 498
+ N+DDC + C NGG C DGVN ++C CPP +TG+ C+ V C P C NG TC
Sbjct: 258 ERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCAN 317
Query: 499 RGHRYVCECARGYGGPNC 516
R Y C C G+ G +C
Sbjct: 318 RNGGYGCVCVNGWSGDDC 335
Score = 227 bits (579), Expect = 3e-59
Identities = 123/349 (35%), Positives = 166/349 (47%), Gaps = 37/349 (10%)
Query: 197 DAFGHFTCGERGEKVCNPGWKGPYCTEPI--CLPGCDEQHGFC-DKPG--ECKCRVGWQG 251
D F+C +C G+ G +C I C G C D G C C +G+ G
Sbjct: 1004 DGINSFSC------LCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTG 1057
Query: 252 RYCDE----CIRYPGCLHGTCQQPW---QCNCQEGWGGLFCNQDLNYC----------TH 294
+ C C R P GTC Q QC C GW G +C+ C
Sbjct: 1058 KNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVE 1117
Query: 295 HKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTC 354
H C++ C N G Y C C GYTG+ CE +DEC +PC++G +C+D Y C C
Sbjct: 1118 HL-CQHSGVCINAGNTHY-CQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCEC 1175
Query: 355 PPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSP- 413
PG+ G CE C + PC NGG C D + + C CP G G CE+ ID C+ P
Sbjct: 1176 VPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNH-FKCSCPPGTRGLLCEENIDDCARGPH 1234
Query: 414 CSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGT--CRDGVNDFSCTCPP 471
C NG +C+D Y CRC GF+G C+ ++++C S+PC++ G+ C ND+ C C
Sbjct: 1235 CLNGGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRS 1294
Query: 472 GYTGRNCSAPVSRCEHAPCHNGATCHERGHR---YVCECARGYGGPNCQ 517
+TGR+C V C PC NG TC + ++C C G+ G CQ
Sbjct: 1295 AFTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQ 1343
Score = 226 bits (575), Expect = 7e-59
Identities = 124/353 (35%), Positives = 170/353 (48%), Gaps = 24/353 (6%)
Query: 201 HFTCGERGEKVCNPGWKGPYCT-EPICLPGCDEQHGFCDKPGE---CKCRVGWQGRYCD- 255
H + E C G+ G C CL C CKC G+ G+ C+
Sbjct: 122 HMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCET 181
Query: 256 ---ECIRYPGCLHG-TCQQ---PWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTG 308
EC C HG TC +QC C +G+ G +C+ C PC NG TC TG
Sbjct: 182 DVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAP-SPCVNGGTCRQTG 240
Query: 309 QGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAM 368
++ C+C PG+ G+TCE ID+C C+NGG C D N+Y+C CPP + G+ C
Sbjct: 241 DFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVD 300
Query: 369 TCADGP--CFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDA 426
C P C NGG C++ +GGY C C G+SG +C + ID C+ + C+ G+ C+D +
Sbjct: 301 ECLLQPNACQNGGTCANR-NGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVAS 359
Query: 427 YLCRCQAGFSGRHCDDNVDD-CASSPCANGGTCRDGV--NDFSCTCPPGYTGRNCSAPVS 483
+ C C G +G C ++DD C S+PC G C + CTCP GY G +C+ V
Sbjct: 360 FSCMCPEGKAGLLC--HLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVD 417
Query: 484 RCEHA---PCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVDLT 533
C A PC + C + CEC +GY GP C+ + E P D T
Sbjct: 418 ECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDAT 470
Score = 169 bits (428), Expect = 8e-42
Identities = 79/236 (33%), Positives = 120/236 (50%), Gaps = 8/236 (3%)
Query: 295 HKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCT--DLENSYSC 352
++PC N C G+ C C G+ G C+ D C+ + C+NGG+C + +C
Sbjct: 32 YEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATC 90
Query: 353 TCPPGFYGKICELSAM--TCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCS 410
C GF G+ C+ S PC NGG C Y C C VG++G C+ D C
Sbjct: 91 RCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQ-WTDACL 149
Query: 411 SSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDC-ASSPCANGGTCRDGVNDFSCTC 469
S PC+NG+ C + + + C+C GF+G+ C+ +V++C C +GGTC + + C C
Sbjct: 150 SHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQC 209
Query: 470 PPGYTGRNCSAPVSRCEHAPCHNGATCHERG-HRYVCECARGYGGPNCQFLLPELP 524
P G+TG+ C + C +PC NG TC + G + C C G+ G C+ + + P
Sbjct: 210 PQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCP 265
Score = 132 bits (333), Expect = 9e-31
Identities = 95/313 (30%), Positives = 128/313 (40%), Gaps = 49/313 (15%)
Query: 212 CNPGWKGPYCTEPICLPGCDE-QHGFCDKPG---------ECKCRVGWQGRYC----DEC 257
C PG++G C + DE Q+ C G +C C G +G C D+C
Sbjct: 1175 CVPGYQGVNCEYEV-----DECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDC 1229
Query: 258 IRYPGCLHG-TCQQP---WQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYT 313
R P CL+G C + C C G+ G C D+N C + G+ Y
Sbjct: 1230 ARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYL 1289
Query: 314 CSCRPGYTGATCELGIDECDPSPCKNGGSC---TDLENSYSCTCPPGFYGKICELSAMTC 370
C CR +TG CE +D C PC NGG+C +++ + + C CPPGF G C+ S C
Sbjct: 1290 CVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSS---C 1346
Query: 371 ADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDA--YL 428
C G +C + G C CP S +CE C+SSPC +G C Y
Sbjct: 1347 GQVKCRKGEQCVHTASGP-RCFCP---SPRDCESG---CASSPCQHGGSCHPQRQPPYYS 1399
Query: 429 CRCQAGFSGRHCD-------DNVDDCASSPCAN---GGTCRDGVNDFSCTCPPGYTGRNC 478
C+C FSG C+ C S CA+ G C + N +C G
Sbjct: 1400 CQCAPPFSGSRCELYTAPPSTPPATCLSQYCADKARDGVCDEACNSHACQWDGGDCSLTM 1459
Query: 479 SAPVSRCEH-APC 490
P + C PC
Sbjct: 1460 ENPWANCSSPLPC 1472
Score = 118 bits (296), Expect = 2e-26
Identities = 69/209 (33%), Positives = 86/209 (41%), Gaps = 48/209 (22%)
Query: 367 AMTCADG--PCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVD-- 422
A+ C DG PC N G C +G C+CP G+ G C+ + D C + C NG CV
Sbjct: 25 ALQCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQA 83
Query: 423 -LG----------------------------------------DAYLCRCQAGFSGRHCD 441
LG D Y C CQ GF+G+ C
Sbjct: 84 MLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKEC- 142
Query: 442 DNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCE-HAPCHNGATCHERG 500
D C S PCANG TC N FSC C G+TG+ C V+ C+ C +G TC
Sbjct: 143 QWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLP 202
Query: 501 HRYVCECARGYGGPNCQFLLPELPPGPAV 529
Y C+C +G+ G C L P P V
Sbjct: 203 GSYQCQCPQGFTGQYCDSLYVPCAPSPCV 231
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 268 bits (685), Expect = 1e-71
Identities = 140/356 (39%), Positives = 179/356 (50%), Gaps = 29/356 (8%)
Query: 197 DAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQH----GFCDKPG---ECKCRVGW 249
DA G F C VC PGW GP C++ + C+ Q G C G C C G
Sbjct: 711 DAPGGFRC------VCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGV 764
Query: 250 QGRYCD---ECIRYPGCLHG-TCQQ-PWQ---CNCQEGWGGLFCNQDLNYCTHHKPCKNG 301
QGR C+ C P C HG C+ P Q C+C +GW G C QD++ C PC
Sbjct: 765 QGRQCELLSPCTPNP-CEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPH 823
Query: 302 ATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGK 361
CTN GS++C+C GYTG +C+ I++CDP+PC NGGSC D S+SC+C PGF G
Sbjct: 824 GICTNLA-GSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGP 882
Query: 362 ICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCV 421
C C PC G C+D ++C CP GY GF+CE+ + CS S C NG CV
Sbjct: 883 RCARDVDECLSNPC-GPGTCTDHV-ASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCV 940
Query: 422 DLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAP 481
D +++ C C+ G++G HC D C S PC +GG C F CTC +TG C
Sbjct: 941 DGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTL 1000
Query: 482 VSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVDLTEKLE 537
V C PC NG C + G C C G+ G C + LP A + +LE
Sbjct: 1001 VDWCSRQPCQNGGRCVQTG--AYCLCPPGWSGRLCD--IRSLPCREAAAQIGVRLE 1052
Score = 267 bits (682), Expect = 3e-71
Identities = 148/420 (35%), Positives = 187/420 (44%), Gaps = 76/420 (18%)
Query: 174 SYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKV---------CNPGWKGPYCTEP 224
+Y C + G+ C V DD GH C G V C P W G +CTE
Sbjct: 219 TYDCACLPGFEGQNCEVNV---DDCPGH-RCLNGGTCVDGVNTYNCQCPPEWTGQFCTED 274
Query: 225 ICLPGCDEQHGFCDKPG---------ECKCRVGWQGRYC----DECIRYPGCLHGT---- 267
+ C Q C G C C GW G C D+C C HG
Sbjct: 275 V--DECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAV-CFHGATCHD 331
Query: 268 ------CQQPWQ---------------------------------CNCQEGWGGLFCNQD 288
C P C C G+ G C+QD
Sbjct: 332 RVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQD 391
Query: 289 LNYCT-HHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLE 347
++ C+ PC++ C NT QGS+ C C GYTG CE ++EC PC+N +C D
Sbjct: 392 VDECSIGANPCEHLGRCVNT-QGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRI 450
Query: 348 NSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKID 407
++C C GF G CE+ C PC NGG C D +G +SC CP G+SG C+ +D
Sbjct: 451 GQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNG-FSCTCPSGFSGSTCQLDVD 509
Query: 408 YCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSC 467
C+S+PC NGAKCVD D Y CRC GF G CD NVDDC+ PC +G C DG+ FSC
Sbjct: 510 ECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHG-RCVDGIASFSC 568
Query: 468 TCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGP 527
C PGYTG C + V C PC +G C + +Y+C C G G NC+ + + P
Sbjct: 569 ACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNP 628
Score = 264 bits (674), Expect = 2e-70
Identities = 151/407 (37%), Positives = 192/407 (47%), Gaps = 71/407 (17%)
Query: 178 VCDEHYYGEGCSVFCRPRDDA-----FGHFTCGERGEK---VCNPGWKGPYC-TEPICLP 228
VC + GE CS + DD F TC +R C G G C + C+
Sbjct: 301 VCVNGWTGESCS---QNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVS 357
Query: 229 GCDEQHGFCDKP-----GECKCRVGWQGRYCD----EC-IRYPGCLH-GTC---QQPWQC 274
+ CD C C G+ G CD EC I C H G C Q + C
Sbjct: 358 NPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLC 417
Query: 275 NCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDP 334
C G+ G C D+N C PC+N ATC + G +TC C G+TG CE+ IDEC
Sbjct: 418 QCGRGYTGPRCETDVNECLSG-PCRNQATCLDR-IGQFTCICMAGFTGTYCEVDIDECQS 475
Query: 335 SPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDG------- 387
SPC NGG C D N +SCTCP GF G C+L CA PC NG +C D PDG
Sbjct: 476 SPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAE 535
Query: 388 -----------------------------GYSCRCPVGYSGFNCEKKIDYCSSSPCSNGA 418
+SC C GY+G CE ++D C S PC +G
Sbjct: 536 GFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGG 595
Query: 419 KCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNC 478
KC+DL D YLCRC +G +G +C+ N+DDCAS+PC G CRDG+N + C C PG+TG C
Sbjct: 596 KCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPC-TFGVCRDGINRYDCVCQPGFTGPLC 654
Query: 479 SAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPP 525
+ ++ C +PC G +C + + + C C G P C LPP
Sbjct: 655 NVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLC------LPP 695
Score = 251 bits (641), Expect = 2e-66
Identities = 136/356 (38%), Positives = 178/356 (50%), Gaps = 32/356 (8%)
Query: 179 CDEHYYGEGCSVFCRPRD------DAFGHFTCGERGEKVCNPGWKGPYCTEPI--CLPG- 229
CD+ + CS+ P + + G F C C G+ GP C + CL G
Sbjct: 388 CDQDV--DECSIGANPCEHLGRCVNTQGSFLCQ------CGRGYTGPRCETDVNECLSGP 439
Query: 230 CDEQHGFCDKPGE--CKCRVGWQGRYC----DECIRYPGCLHGTCQQP---WQCNCQEGW 280
C Q D+ G+ C C G+ G YC DEC P G C+ + C C G+
Sbjct: 440 CRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGF 499
Query: 281 GGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNG 340
G C D++ C PC+NGA C + G Y C C G+ G C+ +D+C P PC +G
Sbjct: 500 SGSTCQLDVDECAS-TPCRNGAKCVDQPDG-YECRCAEGFEGTLCDRNVDDCSPDPCHHG 557
Query: 341 GSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGF 400
C D S+SC C PG+ G CE C PC +GG+C D D Y CRCP G +G
Sbjct: 558 -RCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDK-YLCRCPSGTTGV 615
Query: 401 NCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRD 460
NCE ID C+S+PC+ G C D + Y C CQ GF+G C+ +++CASSPC GG+C D
Sbjct: 616 NCEVNIDDCASNPCTFGV-CRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVD 674
Query: 461 GVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNC 516
G N F C CPPG C P C H PC +G C++ + C C G+ GP C
Sbjct: 675 GENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHG-ICYDAPGGFRCVCEPGWSGPRC 729
Score = 250 bits (638), Expect = 4e-66
Identities = 133/374 (35%), Positives = 180/374 (48%), Gaps = 63/374 (16%)
Query: 212 CNPGWKGPYCTEPI--CLPGCDEQHGFCDKPGE----CKCRVGWQGRYC----DECIRYP 261
C G+ GP C P C P G C + G+ C C G++G+ C D+C P
Sbjct: 185 CPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDC---P 241
Query: 262 G--CLHG-TCQQ---PWQCNCQEGWGGLFCNQDLNYCT-HHKPCKNGATCTNTGQGSYTC 314
G CL+G TC + C C W G FC +D++ C C NG TC NT G ++C
Sbjct: 242 GHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNT-LGGHSC 300
Query: 315 SCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSC---------------------- 352
C G+TG +C ID+C + C +G +C D S+ C
Sbjct: 301 VCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPC 360
Query: 353 -----------------TCPPGFYGKICELSAMTCADG--PCFNGGRCSDSPDGGYSCRC 393
TCPPGF G C+ C+ G PC + GRC ++ G + C+C
Sbjct: 361 HEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNT-QGSFLCQC 419
Query: 394 PVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCA 453
GY+G CE ++ C S PC N A C+D + C C AGF+G +C+ ++D+C SSPC
Sbjct: 420 GRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCV 479
Query: 454 NGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGG 513
NGG C+D VN FSCTCP G++G C V C PC NGA C ++ Y C CA G+ G
Sbjct: 480 NGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEG 539
Query: 514 PNCQFLLPELPPGP 527
C + + P P
Sbjct: 540 TLCDRNVDDCSPDP 553
Score = 238 bits (608), Expect = 1e-62
Identities = 135/380 (35%), Positives = 176/380 (46%), Gaps = 40/380 (10%)
Query: 179 CDEHYYGEGCSVFCRPRDDAFGHFTCGERG---------EKVCNPGWKGPYCTEPI--CL 227
C + + G C + D+ G CG G C+ G+ GP C + I C
Sbjct: 798 CPQGWQGPRCQ---QDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCD 854
Query: 228 PGCDEQHGFC-DKPGE--CKCRVGWQGRYC----DECIRYPGCLHGTCQQ---PWQCNCQ 277
P G C D G C C G+ G C DEC+ P C GTC + C C
Sbjct: 855 PNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNP-CGPGTCTDHVASFTCTCP 913
Query: 278 EGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPC 337
G+GG C QDL C+ C NG TC + G S++C CRPGYTGA C+ D C PC
Sbjct: 914 PGYGGFHCEQDLPDCSPSS-CFNGGTCVD-GVNSFSCLCRPGYTGAHCQHEADPCLSRPC 971
Query: 338 KNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGY 397
+GG C+ + CTC F G C+ C+ PC NGGRC + G C CP G+
Sbjct: 972 LHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQT---GAYCLCPPGW 1028
Query: 398 SGFNCEKKIDYCSSSP----------CSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDC 447
SG C+ + C + C G +CVD ++ C C G +G HC+ VD C
Sbjct: 1029 SGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPC 1088
Query: 448 ASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCEC 507
+ PC +GGTCR + + C C PGY G NC V C PC +G +C + RY+C C
Sbjct: 1089 LAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSC 1148
Query: 508 ARGYGGPNCQFLLPELPPGP 527
G G C+ + PGP
Sbjct: 1149 PPGTLGVLCEINEDDCGPGP 1168
Score = 235 bits (600), Expect = 9e-62
Identities = 119/317 (37%), Positives = 156/317 (49%), Gaps = 20/317 (6%)
Query: 218 GPYCTEPICLPGCDEQHG-----FCDKPGECKCRVGWQGRYC---DECIRYPGCLHGTCQ 269
GP P CL G +G + C C GW G C D C P G CQ
Sbjct: 35 GPGAAAPPCLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQ 94
Query: 270 QP-------WQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTG 322
+ C C G+ G C+ + C PC +GA C+ G + CSC PGY G
Sbjct: 95 SSVVAGTARFSCRCPRGFRGPDCSLP-DPCLS-SPCAHGARCSVGPDGRFLCSCPPGYQG 152
Query: 323 ATCELGIDECDPS-PCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRC 381
+C +DEC PC++GG+C + S+ C CP G+ G +CE A+ CA PC NGG C
Sbjct: 153 RSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTC 212
Query: 382 SDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCD 441
S D Y C C G+ G NCE +D C C NG CVD + Y C+C ++G+ C
Sbjct: 213 RQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCT 272
Query: 442 DNVDDCASSP--CANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHER 499
++VD+C P C NGGTC + + SC C G+TG +CS + C A C +GATCH+R
Sbjct: 273 EDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDR 332
Query: 500 GHRYVCECARGYGGPNC 516
+ C C G G C
Sbjct: 333 VASFYCACPMGKTGLLC 349
Score = 227 bits (579), Expect = 3e-59
Identities = 127/377 (33%), Positives = 170/377 (45%), Gaps = 63/377 (16%)
Query: 211 VCNPGWKGPYC-TEPICLPGCDEQHGFCDKP-------GECKCRVGWQGRYC---DECIR 259
+C PGW G C E C G G C C+C G++G C D C+
Sbjct: 66 LCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLPDPCLS 125
Query: 260 YPGCLHGT-C----QQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTC 314
P C HG C + C+C G+ G C D++ C +PC++G TC NT GS+ C
Sbjct: 126 SP-CAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNT-PGSFRC 183
Query: 315 SCRPGYTGATCELGIDECDPSPCKNGGSCTDL-ENSYSCTCPPGFYGKICELSAMTCADG 373
C GYTG CE C PSPC+NGG+C + +Y C C PGF G+ CE++ C
Sbjct: 184 QCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGH 243
Query: 374 PCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSP--CSNGAKCVDLGDAYLCRC 431
C NGG C D + Y+C+CP ++G C + +D C P C NG C + + C C
Sbjct: 244 RCLNGGTCVDGVN-TYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVC 302
Query: 432 QAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDF-------------------------- 465
G++G C N+DDCA++ C +G TC D V F
Sbjct: 303 VNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHE 362
Query: 466 -------------SCTCPPGYTGRNCSAPVSRCEHA--PCHNGATCHERGHRYVCECARG 510
CTCPPG+TG C V C PC + C ++C+C RG
Sbjct: 363 DAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRG 422
Query: 511 YGGPNCQFLLPELPPGP 527
Y GP C+ + E GP
Sbjct: 423 YTGPRCETDVNECLSGP 439
Score = 217 bits (553), Expect = 3e-56
Identities = 126/352 (35%), Positives = 158/352 (44%), Gaps = 43/352 (12%)
Query: 212 CNPGWKGPYCTEPI--CLPGCDEQHGFCDKPGE-CKCRVGWQGRYCDECIRYPGC----- 263
C + GP C + C + G C + G C C GW GR CD IR C
Sbjct: 988 CLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCD--IRSLPCREAAA 1045
Query: 264 -----LHGTCQQPWQCN---------CQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQ 309
L CQ QC C EG G C Q+++ C +PC++G TC
Sbjct: 1046 QIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLA-QPCQHGGTCRGY-M 1103
Query: 310 GSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMT 369
G Y C C PGY G CE +DEC PC++GGSC DL Y C+CPPG G +CE++
Sbjct: 1104 GGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDD 1163
Query: 370 CADGP-------CFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPC--SNGAKC 420
C GP C + G C D GG+ C CP GY+G CE I+ C S C ++ C
Sbjct: 1164 CGPGPPLDSGPRCLHNGTCVDLV-GGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDC 1222
Query: 421 V-DLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCR-----DGVNDFSCTCPPGYT 474
+ D G + C C AGFSG C + C S PC +GG CR G F+C C +
Sbjct: 1223 LQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFW 1282
Query: 475 GRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPG 526
G C C C G C + C C G GP+C+ P PPG
Sbjct: 1283 GPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCR-SFPGSPPG 1333
Score = 171 bits (432), Expect = 3e-42
Identities = 122/438 (27%), Positives = 162/438 (36%), Gaps = 107/438 (24%)
Query: 175 YRFVCDEHYYGEGCSVFCR--PRDDAFGHFTCGERGEK-VCNPGWKGPYCT--------- 222
+R C E + G C R C + G +C PGW G C
Sbjct: 984 FRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREA 1043
Query: 223 --------EPICLPGCDEQHGFC---DKPGECKCRVGWQGRYC----DECIRYPGCLHG- 266
E +C G G C D C C G G +C D C+ P C HG
Sbjct: 1044 AAQIGVRLEQLCQAG-----GQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQP-CQHGG 1097
Query: 267 TCQQ---PWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGA 323
TC+ + C C G+ G C D++ C +PC++G +C + Y CSC PG G
Sbjct: 1098 TCRGYMGGYMCECLPGYNGDNCEDDVDECAS-QPCQHGGSCIDL-VARYLCSCPPGTLGV 1155
Query: 324 TCELGIDECDPSP-------CKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCF 376
CE+ D+C P P C + G+C DL + CTCPPG+ G CE C G C
Sbjct: 1156 LCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACH 1215
Query: 377 NGGR--CSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDL-----GDAYLC 429
C P GG+ C C G+SG C+ + C S PC +G +C G + C
Sbjct: 1216 AAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTC 1275
Query: 430 RCQAGFSGRHCDD----------------------------------------------N 443
C F G C+ +
Sbjct: 1276 HCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGAS 1335
Query: 444 VDDCASSPCANGGTCRDG--VNDFSCTCPPGYTGRNCSAPVSR---CEHAPCHNGATCHE 498
CA++PC +GG+CR F C C G+TG C AP + E C A +
Sbjct: 1336 NASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAK 1395
Query: 499 RGHRYVCECARGYGGPNC 516
RG + C R P C
Sbjct: 1396 RGDQ---RCDRECNSPGC 1410
Score = 129 bits (325), Expect = 7e-30
Identities = 71/170 (41%), Positives = 90/170 (52%), Gaps = 11/170 (6%)
Query: 366 SAMTCADG-PCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKC---V 421
+A C DG PC NGGRC+ P +C CP G+ G C+ + D C S PC+ C V
Sbjct: 39 AAPPCLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLE-DPCHSGPCAGRGVCQSSV 97
Query: 422 DLGDA-YLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVND-FSCTCPPGYTGRNCS 479
G A + CRC GF G C D C SSPCA+G C G + F C+CPPGY GR+C
Sbjct: 98 VAGTARFSCRCPRGFRGPDCS-LPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCR 156
Query: 480 APVSRCEHA-PCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPA 528
+ V C PC +G TC + C+C GY GP C+ P +P P+
Sbjct: 157 SDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCE--NPAVPCAPS 204
Score = 120 bits (301), Expect = 4e-27
Identities = 116/443 (26%), Positives = 162/443 (36%), Gaps = 86/443 (19%)
Query: 155 VGEEWSQDLHSSGR-TDLKYSYRFVCDEHYYGEGCSVF---CRPRDDAFGHFTCGERGEK 210
+G Q + G+ D S+ VC E G C C + G G G
Sbjct: 1047 IGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGY 1106
Query: 211 VCN--PGWKGPYCTEPI--CLPGCDEQHGFC-DKPGE--CKCRVGWQGRYC----DEC-- 257
+C PG+ G C + + C + G C D C C G G C D+C
Sbjct: 1107 MCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGP 1166
Query: 258 ----IRYPGCLH-GTCQQ---PWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGAT--CTNT 307
P CLH GTC ++C C G+ GL C D+N C C T C
Sbjct: 1167 GPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINEC-RSGACHAAHTRDCLQD 1225
Query: 308 GQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLEN-----SYSCTCPPGFYGKI 362
G + C C G++G C+ + C+ PC++GG C +++C C F+G
Sbjct: 1226 PGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPR 1285
Query: 363 CELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEK--------KIDYCSSSPC 414
CE A +C + C G C +P G C CP G SG +C C+++PC
Sbjct: 1286 CERVARSCRELQCPVGVPCQQTPRGP-RCACPPGLSGPSCRSFPGSPPGASNASCAAAPC 1344
Query: 415 SNGAKC--VDLGDAYLCRCQAGFSGRHC-------------------------DDNVD-D 446
+G C L + C C G++G C D D +
Sbjct: 1345 LHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRE 1404
Query: 447 CASSPCA-NGGTCRDGVNDFSCTCPPGYTGR---------NCSAPVSRCEHAPCHNGA-- 494
C S C +GG C V D C R CS+P ++ CH G
Sbjct: 1405 CNSPGCGWDGGDCSLSVGDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGRE 1464
Query: 495 -TCHERGHRYVCECARGYGGPNC 516
TC+ +Y CA + C
Sbjct: 1465 RTCNPVYEKY---CADHFADGRC 1484
>gi|112420992 crumbs homolog 2 [Homo sapiens]
Length = 1285
Score = 243 bits (621), Expect = 3e-64
Identities = 129/356 (36%), Positives = 171/356 (48%), Gaps = 52/356 (14%)
Query: 200 GHFTCGERGEKVCNPGWKGPYCTEP-----ICLPGCDEQHGFCDKPGECKCRVGWQGRYC 254
G +TCG + C T+P +C+P + GF C C G+QG C
Sbjct: 59 GGYTCGPMEPRGC--------ATQPCHHGALCVPQGPDPTGF-----RCYCVPGFQGPRC 105
Query: 255 ----DECIRYPGCLHG-TCQQ---PWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTN 306
DEC P C HG TC+ ++C+C G+ G+ C +++ C PC +G +C +
Sbjct: 106 ELDIDECASRP-CHHGATCRNLADRYECHCPLGYAGVTCEMEVDECAS-APCLHGGSCLD 163
Query: 307 TGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCP-PGFYGKICEL 365
G GS+ C C PGY G C+L +DEC PC +GG+C DL N + C C G+ G CE
Sbjct: 164 -GVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGFRCDCAGTGYEGTHCER 222
Query: 366 SAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGD 425
+ CA PC + C + G + C C GYSG CE D C+SSPC +G +C+ D
Sbjct: 223 EVLECASAPCEHNASCLEGL-GSFRCLCWPGYSGELCEVDEDECASSPCQHGGRCLQRSD 281
Query: 426 ---------------------AYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVND 464
+LC C GF G C VD+CAS PC NGG C+D N
Sbjct: 282 PALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDECASRPCLNGGHCQDLPNG 341
Query: 465 FSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLL 520
F C CP GY G C V C PC +G TC + Y+C C +GG +C L
Sbjct: 342 FQCHCPDGYAGPTCEEDVDECLSDPCLHGGTCSDTVAGYICRCPETWGGRDCSVQL 397
Score = 220 bits (561), Expect = 3e-57
Identities = 116/330 (35%), Positives = 158/330 (47%), Gaps = 48/330 (14%)
Query: 221 CTEPICLPGCD----EQHGFCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQP----- 271
C C PG + E G+ P E + C P C HG P
Sbjct: 42 CASDPCAPGTECQATESGGYTCGPMEPR-----------GCATQP-CHHGALCVPQGPDP 89
Query: 272 --WQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGI 329
++C C G+ G C D++ C +PC +GATC N Y C C GY G TCE+ +
Sbjct: 90 TGFRCYCVPGFQGPRCELDIDECAS-RPCHHGATCRNLAD-RYECHCPLGYAGVTCEMEV 147
Query: 330 DECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGY 389
DEC +PC +GGSC D S+ C C PG+ G C+L C PC +GG C D +G +
Sbjct: 148 DECASAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNG-F 206
Query: 390 SCRCP-VGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCA 448
C C GY G +CE+++ C+S+PC + A C++ ++ C C G+SG C+ + D+CA
Sbjct: 207 RCDCAGTGYEGTHCEREVLECASAPCEHNASCLEGLGSFRCLCWPGYSGELCEVDEDECA 266
Query: 449 SSPCANGGTCRD--------GVN-------------DFSCTCPPGYTGRNCSAPVSRCEH 487
SSPC +GG C GV F C CPPG+ G +C V C
Sbjct: 267 SSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDECAS 326
Query: 488 APCHNGATCHERGHRYVCECARGYGGPNCQ 517
PC NG C + + + C C GY GP C+
Sbjct: 327 RPCLNGGHCQDLPNGFQCHCPDGYAGPTCE 356
Score = 127 bits (319), Expect = 4e-29
Identities = 62/161 (38%), Positives = 81/161 (50%), Gaps = 13/161 (8%)
Query: 370 CADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGD---A 426
CA PC G C + GGY+C P+ G C++ PC +GA CV G
Sbjct: 42 CASDPCAPGTECQATESGGYTCG-PMEPRG---------CATQPCHHGALCVPQGPDPTG 91
Query: 427 YLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCE 486
+ C C GF G C+ ++D+CAS PC +G TCR+ + + C CP GY G C V C
Sbjct: 92 FRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVDECA 151
Query: 487 HAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGP 527
APC +G +C + + C CA GYGG CQ L E P
Sbjct: 152 SAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQP 192
Score = 119 bits (299), Expect = 8e-27
Identities = 57/154 (37%), Positives = 77/154 (50%), Gaps = 4/154 (2%)
Query: 328 GIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDG 387
G C PSPC + G+C DL ++++C C PG+ G CE C PC GRC PDG
Sbjct: 1056 GAPVCAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCAR-GRCHTHPDG 1114
Query: 388 GYSCRCPVGYSGFNCEKKI--DYCS-SSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNV 444
+ CRCP G+ G C + CS + C +G+ C A C C G +G+ C
Sbjct: 1115 RFECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPT 1174
Query: 445 DDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNC 478
C ++PC NGGTCR C C ++G+ C
Sbjct: 1175 LPCEANPCLNGGTCRAAGGVSECICNARFSGQFC 1208
Score = 99.8 bits (247), Expect = 8e-21
Identities = 51/154 (33%), Positives = 70/154 (45%), Gaps = 17/154 (11%)
Query: 297 PCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPP 356
PC + C + ++ C+C PG+ G CE +D C +PC G T + + C CPP
Sbjct: 1064 PCLHDGACRDLFD-AFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFECRCPP 1122
Query: 357 GFYGKICELSA--------MTCADG-PCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKID 407
GF G C L +TC DG PC G + +C C G +G C+
Sbjct: 1123 GFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAA-------NCSCLEGLAGQRCQVPTL 1175
Query: 408 YCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCD 441
C ++PC NG C G C C A FSG+ C+
Sbjct: 1176 PCEANPCLNGGTCRAAGGVSECICNARFSGQFCE 1209
Score = 94.7 bits (234), Expect = 3e-19
Identities = 63/196 (32%), Positives = 82/196 (41%), Gaps = 32/196 (16%)
Query: 409 CSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCT 468
C+ SPC + C DL DA+ C C G+ G C+ +VD C S+PCA G F C
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFECR 1119
Query: 469 CPPGYTGRNCSAPVSRCE---HAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELP- 524
CPPG+ G C PV E + C +G+ C C C G G CQ +P LP
Sbjct: 1120 CPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQ--VPTLPC 1177
Query: 525 --------------PGPAVVDLTEKLEGQ------GGPFPW------VAVCAGVILVLML 558
G + + GQ G P P VAV A +L+L
Sbjct: 1178 EANPCLNGGTCRAAGGVSECICNARFSGQFCEVAKGLPLPLPFPLLEVAVPAACACLLLL 1237
Query: 559 LLGCAAVVVCVRLRLQ 574
LLG + ++ R R Q
Sbjct: 1238 LLGLLSGILAARKRRQ 1253
Score = 82.8 bits (203), Expect = 1e-15
Identities = 42/126 (33%), Positives = 56/126 (44%), Gaps = 16/126 (12%)
Query: 409 CSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDD--CASSPCANGGTCRDGVND-- 464
C+S PC+ G +C QA SG + ++ CA+ PC +G C D
Sbjct: 42 CASDPCAPGTEC-----------QATESGGYTCGPMEPRGCATQPCHHGALCVPQGPDPT 90
Query: 465 -FSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPEL 523
F C C PG+ G C + C PCH+GATC RY C C GY G C+ + E
Sbjct: 91 GFRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVDEC 150
Query: 524 PPGPAV 529
P +
Sbjct: 151 ASAPCL 156
Score = 80.9 bits (198), Expect = 4e-15
Identities = 47/156 (30%), Positives = 67/156 (42%), Gaps = 15/156 (9%)
Query: 224 PICLPGCDEQHGFCDKPGE---CKCRVGWQGRYC----DECIRYPGCLHGTCQQP----W 272
P+C P G C + C C GW+G C D C P C G C +
Sbjct: 1058 PVCAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAP-CARGRCHTHPDGRF 1116
Query: 273 QCNCQEGWGGLFCNQDL--NYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGID 330
+C C G+GG C + C+ + C +G+ C G + CSC G G C++
Sbjct: 1117 ECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEG-GSPAANCSCLEGLAGQRCQVPTL 1175
Query: 331 ECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELS 366
C+ +PC NGG+C C C F G+ CE++
Sbjct: 1176 PCEANPCLNGGTCRAAGGVSECICNARFSGQFCEVA 1211
Score = 61.6 bits (148), Expect = 2e-09
Identities = 44/132 (33%), Positives = 53/132 (40%), Gaps = 14/132 (10%)
Query: 280 WGGLF--CNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPC 337
WGG F C QDL H P N+ Q S + A C + D C P PC
Sbjct: 759 WGGPFRGCLQDLRLDGCHLPFFP-LPLDNSSQPSELGGRQSWNLTAGC-VSEDMCSPDPC 816
Query: 338 KNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRC---- 393
NGG+C N + CTCP F G C + C PC C + PD G+ C
Sbjct: 817 FNGGTCLVTWNDFHCTCPANFTGPTC-AQQLWCPGQPCLPPATCEEVPD-GFVCVAEATF 874
Query: 394 ----PVGYSGFN 401
P +SG N
Sbjct: 875 REGPPAAFSGHN 886
Score = 60.8 bits (146), Expect = 4e-09
Identities = 34/93 (36%), Positives = 42/93 (45%), Gaps = 7/93 (7%)
Query: 413 PCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPG 472
P N ++ +LG AG D C+ PC NGGTC NDF CTCP
Sbjct: 783 PLDNSSQPSELGGRQSWNLTAGCVSE------DMCSPDPCFNGGTCLVTWNDFHCTCPAN 836
Query: 473 YTGRNCSAPVSRCEHAPCHNGATCHERGHRYVC 505
+TG C+ + C PC ATC E +VC
Sbjct: 837 FTGPTCAQQL-WCPGQPCLPPATCEEVPDGFVC 868
Score = 56.2 bits (134), Expect = 1e-07
Identities = 33/120 (27%), Positives = 54/120 (45%), Gaps = 12/120 (10%)
Query: 320 YTGATCELGIDECD----PSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPC 375
+ G +L +D C P P N ++L S G +S C+ PC
Sbjct: 763 FRGCLQDLRLDGCHLPFFPLPLDNSSQPSELGGRQSWNLTAGC------VSEDMCSPDPC 816
Query: 376 FNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGF 435
FNGG C + + + C CP ++G C +++ +C PC A C ++ D ++C +A F
Sbjct: 817 FNGGTCLVTWND-FHCTCPANFTGPTCAQQL-WCPGQPCLPPATCEEVPDGFVCVAEATF 874
Score = 49.7 bits (117), Expect = 1e-05
Identities = 25/82 (30%), Positives = 35/82 (42%), Gaps = 9/82 (10%)
Query: 407 DYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFS 466
D CS PC NG C+ + + C C A F+G C + C PC TC + + F
Sbjct: 809 DMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPPATCEEVPDGFV 867
Query: 467 CTC--------PPGYTGRNCSA 480
C P ++G N S+
Sbjct: 868 CVAEATFREGPPAAFSGHNASS 889
Score = 39.3 bits (90), Expect = 0.013
Identities = 27/98 (27%), Positives = 36/98 (36%), Gaps = 20/98 (20%)
Query: 212 CNPGWKGPYCTEPI--CLPGCDEQHGFCDKPGE---CKCRVGWQGRYCDECIRYPGCLHG 266
C G+ GP C E + CL G C C+C W GR C ++ GC
Sbjct: 346 CPDGYAGPTCEEDVDECLSDPCLHGGTCSDTVAGYICRCPETWGGRDCS--VQLTGCQGH 403
Query: 267 TCQ-------------QPWQCNCQEGWGGLFCNQDLNY 291
TC + C+C G G FC Q+ +
Sbjct: 404 TCPLAATCIPIFESGVHSYVCHCPPGTHGPFCGQNTTF 441
Score = 38.1 bits (87), Expect = 0.029
Identities = 17/42 (40%), Positives = 22/42 (52%), Gaps = 2/42 (4%)
Query: 330 DECDPSPCKNGGSCTDLENSYSCTCPPGFYGKIC--ELSAMT 369
++C P PC +GGSC DL + C C G C E+ A T
Sbjct: 607 EQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADEIPAAT 648
Score = 35.8 bits (81), Expect = 0.14
Identities = 13/38 (34%), Positives = 21/38 (55%)
Query: 484 RCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLP 521
+C PC +G +C + + C+CAR + GP C +P
Sbjct: 608 QCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADEIP 645
Score = 35.4 bits (80), Expect = 0.19
Identities = 15/43 (34%), Positives = 21/43 (48%), Gaps = 1/43 (2%)
Query: 402 CEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNV 444
CE++ + C PC +G CVDL + C C G C D +
Sbjct: 603 CERR-EQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADEI 644
Score = 34.7 bits (78), Expect = 0.32
Identities = 31/108 (28%), Positives = 39/108 (36%), Gaps = 35/108 (32%)
Query: 422 DLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAP 481
DLG+ L C+ + C PC +GG+C D F C C
Sbjct: 594 DLGENVLLGCERR----------EQCRPLPCVHGGSCVDLWTHFRCDC------------ 631
Query: 482 VSRCEHAPCHNGATCHERGHRYVCECARGYGG--PNCQFLLPELPPGP 527
A H G TC + + G GG + FLL EL PGP
Sbjct: 632 ------ARPHRGPTCADE----IPAATFGLGGAPSSASFLLQEL-PGP 668
Score = 34.7 bits (78), Expect = 0.32
Identities = 17/46 (36%), Positives = 20/46 (43%), Gaps = 5/46 (10%)
Query: 485 CEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLL-----PELPP 525
C PC NG TC + + C C + GP C L P LPP
Sbjct: 811 CSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQLWCPGQPCLPP 856
>gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]
Length = 3144
Score = 237 bits (605), Expect = 2e-62
Identities = 126/379 (33%), Positives = 182/379 (48%), Gaps = 32/379 (8%)
Query: 164 HSSGRTDLKYSYRFVCDEHYYGEGC---SVFCRPRDDAFGHFTCGERGEKV---CNPGWK 217
H+S DL SY+ VC + G C S C+ + + TC + + C GW
Sbjct: 744 HNSTCKDLHLSYQCVCLSDWEGNFCEQESNECK-MNPCKNNSTCTDLYKSYRCECTSGWT 802
Query: 218 GPYCTEPICLPGCDE----QHGFCDK---PGE--CKCRVGWQGRYCDECIRYPGCLHGTC 268
G C+E I CD G C + PG+ C C + G++C + LH C
Sbjct: 803 GQNCSEEI--NECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPC 860
Query: 269 QQ----------PWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRP 318
+ C C+E + G C D+ C C++ C + ++ C CRP
Sbjct: 861 RNNSTCLALVDANQHCICREEFEGKNCEIDVKDCL-FLSCQDYGDCEDM-VNNFRCICRP 918
Query: 319 GYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNG 378
G++G+ CE+ I+EC PCKN G+C DL N + C C P ++G CEL C PC +
Sbjct: 919 GFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCKISPCLDE 978
Query: 379 GRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGR 438
C D GY+C C GY+G NCE +D C S PC + C+D + Y C C++GF G
Sbjct: 979 ENCVYRTD-GYNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGFFGT 1037
Query: 439 HCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHE 498
HC+ N +DC S+PC + G C + +N++ C+C T C ++ C PC N C +
Sbjct: 1038 HCETNANDCLSNPCLH-GRCTELINEYPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQK 1096
Query: 499 RGHRYVCECARGYGGPNCQ 517
H + C C RGY G C+
Sbjct: 1097 SAHGFTCICPRGYTGAYCE 1115
Score = 222 bits (565), Expect = 1e-57
Identities = 116/332 (34%), Positives = 168/332 (50%), Gaps = 22/332 (6%)
Query: 211 VCNPGWKGPYCTEPI--CLPGCDEQHGFCD---KPGECKCRVGWQGRYCD----ECIRYP 261
+C ++G C + CL + +G C+ C CR G+ G C+ EC P
Sbjct: 877 ICREEFEGKNCEIDVKDCLFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECSSEP 936
Query: 262 GCLHGTC---QQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRP 318
+GTC + CNC+ + G FC D+N C PC + C G Y C C P
Sbjct: 937 CKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCKI-SPCLDEENCVYRTDG-YNCLCAP 994
Query: 319 GYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNG 378
GYTG CE+ +DEC PC + G C D N Y+C C GF+G CE +A C PC +G
Sbjct: 995 GYTGINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLSNPCLHG 1054
Query: 379 GRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGR 438
RC++ + Y C C + C+ KI+ C+S PC N C + C C G++G
Sbjct: 1055 -RCTELINE-YPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQKSAHGFTCICPRGYTGA 1112
Query: 439 HCDDNVDDCA-----SSPCANGGTCRDGV-NDFSCTCPPGYTGRNCSAPVSRCEHAPCHN 492
+C+ ++D+CA S C NGG C DG + F C C PG++G+ C ++ C +PC +
Sbjct: 1113 YCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCEININECSSSPCLH 1172
Query: 493 GATCHERGHRYVCECARGYGGPNCQFLLPELP 524
GA C + + YVC+C G+ G +C+ L +P
Sbjct: 1173 GADCEDHINGYVCKCQPGWSGHHCENELECIP 1204
Score = 218 bits (556), Expect = 1e-56
Identities = 126/351 (35%), Positives = 163/351 (46%), Gaps = 34/351 (9%)
Query: 212 CNPGWKGPYCTEPI-------CLPG--CDEQHG--FCD--------KPGECKCRVGWQGR 252
C PG+KG C I C G C +Q G FC C C G+ G
Sbjct: 669 CVPGFKGTQCEIDIDECASHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGI 728
Query: 253 YC----DECIRYPGCLHG-TCQQ---PWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATC 304
C D+CI C H TC+ +QC C W G FC Q+ N C + PCKN +TC
Sbjct: 729 RCEQDIDDCI-LNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQESNECKMN-PCKNNSTC 786
Query: 305 TNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTD--LENSYSCTCPPGFYGKI 362
T+ + SY C C G+TG C I+ECD PC NGG C + + + C CPP + G+
Sbjct: 787 TDLYK-SYRCECTSGWTGQNCSEEINECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQF 845
Query: 363 CELSAMTC--ADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKC 420
C C PC N C D C C + G NCE + C C + C
Sbjct: 846 CHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLSCQDYGDC 905
Query: 421 VDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSA 480
D+ + + C C+ GFSG C+ +++C+S PC N GTC D N F C C P Y G C
Sbjct: 906 EDMVNNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCEL 965
Query: 481 PVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVD 531
V++C+ +PC + C R Y C CA GY G NC+ L E P + D
Sbjct: 966 DVNKCKISPCLDEENCVYRTDGYNCLCAPGYTGINCEINLDECLSEPCLHD 1016
Score = 213 bits (543), Expect = 4e-55
Identities = 112/342 (32%), Positives = 164/342 (47%), Gaps = 24/342 (7%)
Query: 192 CRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPI--CLPGCDEQHGFCDK---PGECKCR 246
C P F+C +CNPG+ G C + I C+ E + C +C C
Sbjct: 707 CVPPFKVVDGFSC------LCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCL 760
Query: 247 VGWQGRYCD----ECIRYPGCLHGTCQ---QPWQCNCQEGWGGLFCNQDLNYCTHHKPCK 299
W+G +C+ EC P + TC + ++C C GW G C++++N C PC
Sbjct: 761 SDWEGNFCEQESNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDSD-PCM 819
Query: 300 NGATC-TNTGQGSYTCSCRPGYTGATCELGIDECD--PSPCKNGGSCTDL-ENSYSCTCP 355
NG C +T G + C C P YTG C + CD +PC+N +C L + + C C
Sbjct: 820 NGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICR 879
Query: 356 PGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCS 415
F GK CE+ C C + G C D + + C C G+SG CE +I+ CSS PC
Sbjct: 880 EEFEGKNCEIDVKDCLFLSCQDYGDCEDMVNN-FRCICRPGFSGSLCEIEINECSSEPCK 938
Query: 416 NGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTG 475
N CVDL + + C C+ + G C+ +V+ C SPC + C + ++C C PGYTG
Sbjct: 939 NNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCKISPCLDEENCVYRTDGYNCLCAPGYTG 998
Query: 476 RNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQ 517
NC + C PC + C + + Y C+C G+ G +C+
Sbjct: 999 INCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCE 1040
Score = 212 bits (539), Expect = 1e-54
Identities = 105/334 (31%), Positives = 155/334 (46%), Gaps = 17/334 (5%)
Query: 211 VCNPGWKGPYCTEPI--CLPGCDEQHGFCD---KPGECKCRVGWQGRYCDE--------- 256
VC W+G +C + C + + C K C+C GW G+ C E
Sbjct: 758 VCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDSDP 817
Query: 257 CIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTH-HKPCKNGATCTNTGQGSYTCS 315
C+ C T + C C + G FC+Q N C H PC+N +TC + C
Sbjct: 818 CMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCI 877
Query: 316 CRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPC 375
CR + G CE+ + +C C++ G C D+ N++ C C PGF G +CE+ C+ PC
Sbjct: 878 CREEFEGKNCEIDVKDCLFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECSSEPC 937
Query: 376 FNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGF 435
N G C D + + C C Y G CE ++ C SPC + CV D Y C C G+
Sbjct: 938 KNNGTCVDLTNR-FFCNCEPEYHGPFCELDVNKCKISPCLDEENCVYRTDGYNCLCAPGY 996
Query: 436 SGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGAT 495
+G +C+ N+D+C S PC + G C DG+N ++C C G+ G +C + C PC +G
Sbjct: 997 TGINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLSNPCLHG-R 1055
Query: 496 CHERGHRYVCECARGYGGPNCQFLLPELPPGPAV 529
C E + Y C C C+ + + P +
Sbjct: 1056 CTELINEYPCSCDADGTSTQCKIKINDCTSIPCM 1089
Score = 181 bits (460), Expect = 2e-45
Identities = 107/327 (32%), Positives = 157/327 (48%), Gaps = 29/327 (8%)
Query: 170 DLKYSYRFVCDEHYYGEGCSVFCRP--RDDAFGHFTCGERGEKV---CNPGWKGPYCTEP 224
D+ ++R +C + G C + + + TC + + C P + GP+C
Sbjct: 907 DMVNNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELD 966
Query: 225 I----CLPGCDEQHGFCDKPG-ECKCRVGWQGRYC----DECIRYPGCLH-GTCQQP--- 271
+ P DE++ G C C G+ G C DEC+ P CLH G C
Sbjct: 967 VNKCKISPCLDEENCVYRTDGYNCLCAPGYTGINCEINLDECLSEP-CLHDGVCIDGINH 1025
Query: 272 WQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDE 331
+ C+C+ G+ G C + N C + PC +G CT Y CSC T C++ I++
Sbjct: 1026 YTCDCKSGFFGTHCETNANDCLSN-PCLHGR-CTEL-INEYPCSCDADGTSTQCKIKIND 1082
Query: 332 CDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGP-----CFNGGRCSDSPD 386
C PC N G C + ++C CP G+ G CE S CA+ C NGG C D P
Sbjct: 1083 CTSIPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPG 1142
Query: 387 GGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDD 446
+ CRC G+SG CE I+ CSSSPC +GA C D + Y+C+CQ G+SG HC++ + +
Sbjct: 1143 HTFDCRCLPGFSGQFCEININECSSSPCLHGADCEDHINGYVCKCQPGWSGHHCENEL-E 1201
Query: 447 CASSPCANGGTCRDGVNDFSCTCPPGY 473
C + C + C + +C C PG+
Sbjct: 1202 CIPNSCVH-ELCMENEPGSTCLCTPGF 1227
Score = 155 bits (391), Expect = 2e-37
Identities = 87/280 (31%), Positives = 123/280 (43%), Gaps = 15/280 (5%)
Query: 252 RYCDECIRYPGCL-HGTC-----QQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCT 305
++C E + C HG C + + C+CQ + G +C Q+L+ C+ KPCKN +C
Sbjct: 172 QFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYC-QELDACSF-KPCKNNGSCI 229
Query: 306 NTGQG----SYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGK 361
N + +Y C C P +TG C I +C P C +G NS+ C C F G
Sbjct: 230 NKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGP 289
Query: 362 ICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCV 421
CE+SA C + G C +S Y+ CP G S N E + S PC NG C+
Sbjct: 290 FCEVSAKPCVSLLFWKRGICPNS-SSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCI 348
Query: 422 DLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAP 481
+ + +C C F+ C C S P N TC+ D+ C+C G+T +NC
Sbjct: 349 KISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKA 408
Query: 482 VSRCE--HAPCHNGATCHERGHRYVCECARGYGGPNCQFL 519
+ C+ C N C R+ C G C FL
Sbjct: 409 IDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFL 448
Score = 108 bits (271), Expect = 1e-23
Identities = 85/349 (24%), Positives = 125/349 (35%), Gaps = 70/349 (20%)
Query: 225 ICLPGCDEQ----------------------HGFCDKPGECKCRVGWQGRYCDECIRYPG 262
+C+PGC + HG C G + WQ + + G
Sbjct: 435 VCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQ-------LGFAG 487
Query: 263 CLHGTCQQPWQC------NCQEGWGGLFCNQDLN---YCTHH---KPCKNGATCTNTGQG 310
CQ NC E + +D N + H + C NG +C +
Sbjct: 488 SEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEEDS 547
Query: 311 S-YTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMT 369
Y C + G + + C++ C D N C+C + G++C ++
Sbjct: 548 QEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRCSCSLSYIGRLCVVNVDY 607
Query: 370 CADGPCFNGGRCSDSPDG-----GYSCRCP--VGYSGFNCEKKIDYCSSSPCSNGAKCVD 422
C G S S G ++C C Y CE + C S+ C NG
Sbjct: 608 CL-------GNHSISVHGLCLALSHNCNCSGLQRYERNICEIDTEDCKSASCKNGTTSTH 660
Query: 423 LGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDG--------------VNDFSCT 468
L + +C GF G C+ ++D+CAS PC NG TC D V+ FSC
Sbjct: 661 LRGYFFRKCVPGFKGTQCEIDIDECASHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCL 720
Query: 469 CPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQ 517
C PGY G C + C C + +TC + Y C C + G C+
Sbjct: 721 CNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCE 769
Score = 77.0 bits (188), Expect = 6e-14
Identities = 98/435 (22%), Positives = 142/435 (32%), Gaps = 113/435 (25%)
Query: 179 CDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCD 238
CDE + G C V +P +RG +C P Y E C G Q+G D
Sbjct: 282 CDEQFSGPFCEVSAKP----CVSLLFWKRG--IC-PNSSSAYTYE--CPKGSSSQNGETD 332
Query: 239 --KPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHK 296
+ C+ G +CI+ + C C + L C C
Sbjct: 333 VSEFSLVPCQNG------TDCIKISNDV--------MCICSPIFTDLLCKSIQTSCESF- 377
Query: 297 PCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECD--PSPCKNGGSCTDLENSYSCTC 354
P +N ATC + Y CSC G+T CE ID C C N C ++ + C
Sbjct: 378 PLRNNATCKKC-EKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVC 436
Query: 355 PPG-------FYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSG-------- 399
PG F + + C G F+ G C D + +G++G
Sbjct: 437 IPGCTKNPCWFLKNVYLIHQHLCYCGVTFH-GICQDKGPAQFEYVWQLGFAGSEGEKCQG 495
Query: 400 ---------FNCEKKIDYCSSSP----------------CSNGAKCVDLGDA--YLCRCQ 432
NC + Y + C+NG C+ D+ Y C
Sbjct: 496 VIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEEDSQEYRYLCF 555
Query: 433 AGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGR---------------- 476
++G +N D + C + C+D +N C+C Y GR
Sbjct: 556 LRWAGNMYLENTTDDQENECQHEAVCKDEINRPRCSCSLSYIGRLCVVNVDYCLGNHSIS 615
Query: 477 ------------NCSA-----------PVSRCEHAPCHNGAT-CHERGHRYVCECARGYG 512
NCS C+ A C NG T H RG+ + +C G+
Sbjct: 616 VHGLCLALSHNCNCSGLQRYERNICEIDTEDCKSASCKNGTTSTHLRGY-FFRKCVPGFK 674
Query: 513 GPNCQFLLPELPPGP 527
G C+ + E P
Sbjct: 675 GTQCEIDIDECASHP 689
Score = 63.2 bits (152), Expect = 8e-10
Identities = 47/166 (28%), Positives = 61/166 (36%), Gaps = 36/166 (21%)
Query: 328 GIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDG 387
G E P NG D +N GF G I L T DG G P+
Sbjct: 2554 GYSEYTPDLLPNGA---DFKN--------GFQGCIFTLQVRTEKDGHFRGLGNPEGHPNA 2602
Query: 388 GYSCRCPVGYSGFNCEKKIDYCSSSPCS-----NGAKCVDLGDAYLCRCQAGFSGRHCDD 442
G S + C +SPCS NG C++ G + C C G+ G C +
Sbjct: 2603 GRS---------------VGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTE 2647
Query: 443 NVDDC-----ASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVS 483
V C C+ G TC + ++C CP G TG C +S
Sbjct: 2648 TVSTCDPEHDPPHHCSRGATCISLPHGYTCFCPLGTTGIYCEQALS 2693
Score = 61.2 bits (147), Expect = 3e-09
Identities = 45/139 (32%), Positives = 57/139 (41%), Gaps = 23/139 (16%)
Query: 300 NGATCTNTGQGS-YTCSCRPGYTGATCELG-----------IDECDPSPCK-----NGGS 342
NGA N QG +T R G LG + +C SPC NGG+
Sbjct: 2565 NGADFKNGFQGCIFTLQVRTEKDGHFRGLGNPEGHPNAGRSVGQCHASPCSLMKCGNGGT 2624
Query: 343 CTDLENSYSCTCPPGFYGKICELSAMTCA---DGP--CFNGGRCSDSPDGGYSCRCPVGY 397
C + S C C G+ G C + TC D P C G C P G Y+C CP+G
Sbjct: 2625 CIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHG-YTCFCPLGT 2683
Query: 398 SGFNCEKKIDYCSSSPCSN 416
+G CE+ + S SN
Sbjct: 2684 TGIYCEQALSISDPSFRSN 2702
Score = 60.8 bits (146), Expect = 4e-09
Identities = 33/85 (38%), Positives = 40/85 (47%), Gaps = 10/85 (11%)
Query: 443 NVDDCASSPCA-----NGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRC--EHAP---CHN 492
+V C +SPC+ NGGTC + C C G+ G C+ VS C EH P C
Sbjct: 2605 SVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSR 2664
Query: 493 GATCHERGHRYVCECARGYGGPNCQ 517
GATC H Y C C G G C+
Sbjct: 2665 GATCISLPHGYTCFCPLGTTGIYCE 2689
Score = 60.1 bits (144), Expect = 7e-09
Identities = 27/85 (31%), Positives = 41/85 (48%), Gaps = 1/85 (1%)
Query: 332 CDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSC 391
C + C+NGG CT ++SC C P + G C S ++C + C + C YSC
Sbjct: 2879 CGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQS-VSCLNNLCLHQSLCIPDQSFSYSC 2937
Query: 392 RCPVGYSGFNCEKKIDYCSSSPCSN 416
C +G+ G CE K + ++ N
Sbjct: 2938 LCTLGWVGRYCENKTSFSTAKFMGN 2962
Score = 59.7 bits (143), Expect = 9e-09
Identities = 30/71 (42%), Positives = 36/71 (50%), Gaps = 3/71 (4%)
Query: 447 CASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATC-HERGHRYVC 505
CA C N GTC + C CP Y+G+ C + CE+ PC NGATC + G VC
Sbjct: 2339 CAHHLCRNNGTCISDNENLFCECPRLYSGKLCQ--FASCENNPCGNGATCVPKSGTDIVC 2396
Query: 506 ECARGYGGPNC 516
C G GP C
Sbjct: 2397 LCPYGRSGPLC 2407
Score = 58.9 bits (141), Expect = 2e-08
Identities = 37/97 (38%), Positives = 44/97 (45%), Gaps = 13/97 (13%)
Query: 251 GRYCDECIRYPGCLH-----GTCQQPWQ---CNCQEGWGGLFCNQDLNYC-THHKP---C 298
GR +C P L GTC + CNC GW G FC + ++ C H P C
Sbjct: 2603 GRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHC 2662
Query: 299 KNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPS 335
GATC + G YTC C G TG CE + DPS
Sbjct: 2663 SRGATCISLPHG-YTCFCPLGTTGIYCEQALSISDPS 2698
Score = 54.7 bits (130), Expect = 3e-07
Identities = 25/76 (32%), Positives = 35/76 (46%), Gaps = 2/76 (2%)
Query: 332 CDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSC 391
C C+N G+C + C CP + GK+C+ + +C + PC NG C C
Sbjct: 2339 CAHHLCRNNGTCISDNENLFCECPRLYSGKLCQFA--SCENNPCGNGATCVPKSGTDIVC 2396
Query: 392 RCPVGYSGFNCEKKID 407
CP G SG C I+
Sbjct: 2397 LCPYGRSGPLCTDAIN 2412
Score = 52.8 bits (125), Expect = 1e-06
Identities = 26/85 (30%), Positives = 40/85 (47%), Gaps = 7/85 (8%)
Query: 401 NCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTC-- 458
NC + +C+ C N C+ + C C +SG+ C C ++PC NG TC
Sbjct: 2333 NCH--VPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLC--QFASCENNPCGNGATCVP 2388
Query: 459 RDGVNDFSCTCPPGYTGRNCSAPVS 483
+ G D C CP G +G C+ ++
Sbjct: 2389 KSG-TDIVCLCPYGRSGPLCTDAIN 2412
Score = 50.8 bits (120), Expect = 4e-06
Identities = 24/78 (30%), Positives = 32/78 (41%), Gaps = 2/78 (2%)
Query: 440 CDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHER 499
CD C + C NGG C FSC C P + G C+ VS + H ++
Sbjct: 2874 CDGTA--CGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQ 2931
Query: 500 GHRYVCECARGYGGPNCQ 517
Y C C G+ G C+
Sbjct: 2932 SFSYSCLCTLGWVGRYCE 2949
Score = 50.4 bits (119), Expect = 6e-06
Identities = 24/76 (31%), Positives = 36/76 (47%), Gaps = 2/76 (2%)
Query: 409 CSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTC-RDGVNDFSC 467
C + C NG +C G + CRC ++G C+ +V C ++ C + C D +SC
Sbjct: 2879 CGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSV-SCLNNLCLHQSLCIPDQSFSYSC 2937
Query: 468 TCPPGYTGRNCSAPVS 483
C G+ GR C S
Sbjct: 2938 LCTLGWVGRYCENKTS 2953
Score = 50.4 bits (119), Expect = 6e-06
Identities = 25/71 (35%), Positives = 36/71 (50%), Gaps = 3/71 (4%)
Query: 295 HKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSC-TDLENSYSCT 353
+ C+NG CT G +++C C P + G TC + C + C + C D SYSC
Sbjct: 2881 YNTCRNGGECTVNGT-TFSCRCLPDWAGNTCNQSV-SCLNNLCLHQSLCIPDQSFSYSCL 2938
Query: 354 CPPGFYGKICE 364
C G+ G+ CE
Sbjct: 2939 CTLGWVGRYCE 2949
Score = 48.1 bits (113), Expect = 3e-05
Identities = 23/74 (31%), Positives = 40/74 (54%), Gaps = 3/74 (4%)
Query: 370 CADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCV-DLGDAYL 428
C C NGG C+ + +SCRC ++G C + + C ++ C + + C+ D +Y
Sbjct: 2879 CGYNTCRNGGECTVNGTT-FSCRCLPDWAGNTCNQSVS-CLNNLCLHQSLCIPDQSFSYS 2936
Query: 429 CRCQAGFSGRHCDD 442
C C G+ GR+C++
Sbjct: 2937 CLCTLGWVGRYCEN 2950
Score = 43.5 bits (101), Expect = 7e-04
Identities = 31/91 (34%), Positives = 38/91 (41%), Gaps = 24/91 (26%)
Query: 203 TCGERGEKV---CNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCDECIR 259
TC E G V C GWKG +CTE + CD +H D P C CI
Sbjct: 2624 TCIESGTSVYCNCTTGWKGSFCTETVST--CDPEH---DPPHHCSRGA--------TCIS 2670
Query: 260 YPGCLHGTCQQPWQCNCQEGWGGLFCNQDLN 290
P HG + C C G G++C Q L+
Sbjct: 2671 LP---HG-----YTCFCPLGTTGIYCEQALS 2693
Score = 43.1 bits (100), Expect = 9e-04
Identities = 22/88 (25%), Positives = 36/88 (40%), Gaps = 8/88 (9%)
Query: 445 DDCASSPCANGGTCRDGV--NDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHR 502
+ +S C+ G C +SC C P ++G+ C + C PC N +C +
Sbjct: 176 ESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQE-LDACSFKPCKNNGSCINKREN 234
Query: 503 -----YVCECARGYGGPNCQFLLPELPP 525
Y C C + G NC ++ + P
Sbjct: 235 WDEQAYECVCHPPFTGKNCSEIIGQCQP 262
Score = 39.7 bits (91), Expect = 0.010
Identities = 20/49 (40%), Positives = 20/49 (40%), Gaps = 2/49 (4%)
Query: 477 NCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPP 525
NC P C H C N TC CEC R Y G CQF E P
Sbjct: 2333 NCHVPW--CAHHLCRNNGTCISDNENLFCECPRLYSGKLCQFASCENNP 2379
Score = 38.9 bits (89), Expect = 0.017
Identities = 21/73 (28%), Positives = 32/73 (43%), Gaps = 11/73 (15%)
Query: 263 CLHGTCQQ---------PWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYT 313
C + TC+ + C C W G CNQ ++ C ++ C + + C SY+
Sbjct: 2879 CGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVS-CLNNL-CLHQSLCIPDQSFSYS 2936
Query: 314 CSCRPGYTGATCE 326
C C G+ G CE
Sbjct: 2937 CLCTLGWVGRYCE 2949
Score = 37.4 bits (85), Expect = 0.049
Identities = 16/37 (43%), Positives = 18/37 (48%), Gaps = 5/37 (13%)
Query: 447 CASSPCANGGTCR-----DGVNDFSCTCPPGYTGRNC 478
C C NGGTC G+ F C CP +TGR C
Sbjct: 2103 CQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFC 2139
Score = 37.4 bits (85), Expect = 0.049
Identities = 27/93 (29%), Positives = 35/93 (37%), Gaps = 13/93 (13%)
Query: 251 GRYCDECIRYPGCLH------GTC---QQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNG 301
G+ + C P C H GTC + C C + G C C ++ PC NG
Sbjct: 2328 GKNIENC-HVPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQ--FASCENN-PCGNG 2383
Query: 302 ATCTNTGQGSYTCSCRPGYTGATCELGIDECDP 334
ATC C C G +G C I+ P
Sbjct: 2384 ATCVPKSGTDIVCLCPYGRSGPLCTDAINITQP 2416
Score = 35.8 bits (81), Expect = 0.14
Identities = 22/72 (30%), Positives = 27/72 (37%), Gaps = 14/72 (19%)
Query: 198 AFGHFTCGERGEKV---------CNPGWKGPYCTEPI-CLPGCDEQHGFCDKPGE----C 243
A G+ TC GE C P W G C + + CL C C
Sbjct: 2878 ACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSFSYSC 2937
Query: 244 KCRVGWQGRYCD 255
C +GW GRYC+
Sbjct: 2938 LCTLGWVGRYCE 2949
Score = 34.3 bits (77), Expect = 0.42
Identities = 20/59 (33%), Positives = 25/59 (42%), Gaps = 7/59 (11%)
Query: 332 CDPSPCKNGGSCTDLENS-----YSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSP 385
C C NGG+C + S + C CP F G+ CE A P FNG + P
Sbjct: 2103 CQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDAGLFF--PSFNGNSYLELP 2159
Score = 34.3 bits (77), Expect = 0.42
Identities = 16/58 (27%), Positives = 25/58 (43%), Gaps = 7/58 (12%)
Query: 243 CKCRVGWQGRYCDECIRYPG--CLHGTCQQP-----WQCNCQEGWGGLFCNQDLNYCT 293
C+C W G C++ + CLH + P + C C GW G +C ++ T
Sbjct: 2899 CRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYCENKTSFST 2956
Score = 30.8 bits (68), Expect = 4.6
Identities = 19/58 (32%), Positives = 25/58 (43%), Gaps = 6/58 (10%)
Query: 370 CADGPCFNGGRCS----DSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDL 423
C C NGG C S + C CP+ ++G CEK D P NG ++L
Sbjct: 2103 CQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEK--DAGLFFPSFNGNSYLEL 2158
>gi|41327708 crumbs homolog 1 precursor [Homo sapiens]
Length = 1406
Score = 236 bits (603), Expect = 4e-62
Identities = 113/272 (41%), Positives = 141/272 (51%), Gaps = 10/272 (3%)
Query: 257 CIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSC 316
C+ PG ++ + C C G+ G C + C + C++G C + C C
Sbjct: 85 CVNTPG------ERSFLCKCPPGYSGTICETTIGSCGKNS-CQHGGIC-HQDPIYPVCIC 136
Query: 317 RPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCF 376
GY G CE+ DEC SPC+NG C D + YSC C PG+ G+ C+L CA PC
Sbjct: 137 PAGYAGRFCEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPCK 196
Query: 377 NGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFS 436
N C + G Y+C CP YSG NCE +ID C S PC NGA C D AY C C GF
Sbjct: 197 NEATCLNE-IGRYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDALGAYFCDCAPGFL 255
Query: 437 GRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCP-PGYTGRNCSAPVSRCEHAPCHNGAT 495
G HC+ N D+CAS PC +GG C DG N +SC C G+TG +C + C PCHN AT
Sbjct: 256 GDHCELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWSKPCHNNAT 315
Query: 496 CHERGHRYVCECARGYGGPNCQFLLPELPPGP 527
C + Y C C GY G C+ L E P
Sbjct: 316 CEDSVDNYTCHCWPGYTGAQCEIDLNECNSNP 347
Score = 232 bits (592), Expect = 8e-61
Identities = 133/381 (34%), Positives = 180/381 (47%), Gaps = 64/381 (16%)
Query: 211 VCNPGWKGPYCT---EPICLPGCDEQHGFCDKPG----ECKCRVGWQGRYCD----ECIR 259
+C G+ G +C + C Q+G + G C C G+QGR+CD EC
Sbjct: 135 ICPAGYAGRFCEIDHDECASSPC--QNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECAS 192
Query: 260 YPGCLHGTCQQP---WQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSC 316
P TC + C C + G+ C +++ C +PC NGATC + G+Y C C
Sbjct: 193 DPCKNEATCLNEIGRYTCICPHNYSGVNCELEIDECWS-QPCLNGATCQDA-LGAYFCDC 250
Query: 317 RPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCP-PGFYGKICELSAMTCADGPC 375
PG+ G CEL DEC PC +GG C D EN YSC C GF G CE C PC
Sbjct: 251 APGFLGDHCELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWSKPC 310
Query: 376 FNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGD---------- 425
N C DS D Y+C C GY+G CE ++ C+S+PC + +CV+L
Sbjct: 311 HNNATCEDSVDN-YTCHCWPGYTGAQCEIDLNECNSNPCQSNGECVELSSEKQYGRITGL 369
Query: 426 ----------AYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCP----- 470
Y+C CQ GF+G HC+++V++C+S+PC NGGTC + +++C CP
Sbjct: 370 PSSFSYHEASGYVCICQPGFTGIHCEEDVNECSSNPCQNGGTCENLPGNYTCHCPFDNLS 429
Query: 471 -PGYTGRNCSAPVSRCEHAPCHNGATC----HERGHRYVCECARGYGGPNCQFLLPELPP 525
Y GR+CS + C H C N TC + H + C C GY G C+
Sbjct: 430 RTFYGGRDCSDILLGCTHQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCE-------- 481
Query: 526 GPAVVDLTEKLEGQGGPFPWV 546
+ T EG G F WV
Sbjct: 482 ----IATTLSFEGDG--FLWV 496
Score = 225 bits (573), Expect = 1e-58
Identities = 118/320 (36%), Positives = 153/320 (47%), Gaps = 35/320 (10%)
Query: 240 PGE----CKCRVGWQGRYCDECIRYPG---CLHG-TCQQPW---QCNCQEGWGGLFCNQD 288
PGE CKC G+ G C+ I G C HG C Q C C G+ G FC D
Sbjct: 89 PGERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRFCEID 148
Query: 289 LNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLEN 348
+ C PC+NGA C + G Y+C C PGY G C+L +DEC PCKN +C +
Sbjct: 149 HDECAS-SPCQNGAVCQD-GIDGYSCFCVPGYQGRHCDLEVDECASDPCKNEATCLNEIG 206
Query: 349 SYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDY 408
Y+C CP + G CEL C PC NG C D+ G Y C C G+ G +CE D
Sbjct: 207 RYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDAL-GAYFCDCAPGFLGDHCELNTDE 265
Query: 409 CSSSPCSNGAKCVDLGDAYLCRCQ-AGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSC 467
C+S PC +G CVD + Y C C +GF+G HC+ + C S PC N TC D V++++C
Sbjct: 266 CASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWSKPCHNNATCEDSVDNYTC 325
Query: 468 TCPPGYTGRNCSAPVSRCEHAPCHNGATC--------------------HERGHRYVCEC 507
C PGYTG C ++ C PC + C + YVC C
Sbjct: 326 HCWPGYTGAQCEIDLNECNSNPCQSNGECVELSSEKQYGRITGLPSSFSYHEASGYVCIC 385
Query: 508 ARGYGGPNCQFLLPELPPGP 527
G+ G +C+ + E P
Sbjct: 386 QPGFTGIHCEEDVNECSSNP 405
Score = 214 bits (545), Expect = 2e-55
Identities = 101/271 (37%), Positives = 138/271 (50%), Gaps = 13/271 (4%)
Query: 263 CLHGTCQQPWQCNCQEGWGGLFCNQDLNY----CTHHK------PCKNGATCTNT-GQGS 311
CL +CQ C C+ N C + K PC+ ATC NT G+ S
Sbjct: 34 CLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSATCVNTPGERS 93
Query: 312 YTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCA 371
+ C C PGY+G CE I C + C++GG C C CP G+ G+ CE+ CA
Sbjct: 94 FLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRFCEIDHDECA 153
Query: 372 DGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRC 431
PC NG C D DG YSC C GY G +C+ ++D C+S PC N A C++ Y C C
Sbjct: 154 SSPCQNGAVCQDGIDG-YSCFCVPGYQGRHCDLEVDECASDPCKNEATCLNEIGRYTCIC 212
Query: 432 QAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCH 491
+SG +C+ +D+C S PC NG TC+D + + C C PG+ G +C C PC
Sbjct: 213 PHNYSGVNCELEIDECWSQPCLNGATCQDALGAYFCDCAPGFLGDHCELNTDECASQPCL 272
Query: 492 NGATCHERGHRYVCEC-ARGYGGPNCQFLLP 521
+G C + +RY C C G+ G +C+ L+P
Sbjct: 273 HGGLCVDGENRYSCNCTGSGFTGTHCETLMP 303
Score = 202 bits (514), Expect = 9e-52
Identities = 96/249 (38%), Positives = 131/249 (52%), Gaps = 5/249 (2%)
Query: 284 FCNQDLNYCTHHKPCKNGATCTNTGQGS-YTCSCRPGYTGATCELGIDECDPSPCKNGGS 342
FCN++ C + C+N +TC + + + +CS C+ D C +PC+ +
Sbjct: 26 FCNKNNTRCLSNS-CQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSAT 84
Query: 343 CTDL--ENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGF 400
C + E S+ C CPPG+ G ICE + +C C +GG C P C CP GY+G
Sbjct: 85 CVNTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPV-CICPAGYAGR 143
Query: 401 NCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRD 460
CE D C+SSPC NGA C D D Y C C G+ GRHCD VD+CAS PC N TC +
Sbjct: 144 FCEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPCKNEATCLN 203
Query: 461 GVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLL 520
+ ++C CP Y+G NC + C PC NGATC + Y C+CA G+ G +C+
Sbjct: 204 EIGRYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDALGAYFCDCAPGFLGDHCELNT 263
Query: 521 PELPPGPAV 529
E P +
Sbjct: 264 DECASQPCL 272
Score = 164 bits (414), Expect = 3e-40
Identities = 83/250 (33%), Positives = 121/250 (48%), Gaps = 27/250 (10%)
Query: 327 LGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPD 386
L ++ C+ +PC +GG+C D+ +SY C+CP G+ GK CEL+ C PC +G CSD
Sbjct: 1138 LQLNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGN-CSDRV- 1195
Query: 387 GGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNV-- 444
Y C C GY+G NCE ID C S C+NGA C+ + Y C C F+G+ C +
Sbjct: 1196 AAYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLP 1255
Query: 445 -----DDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHER 499
++ + C NGG C + + C C PG+TG C + C PC NG C +
Sbjct: 1256 STVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDL 1315
Query: 500 GHRYVCECARGYGGPNCQFLLPELPPGPAVVDLTEKLEGQGGPFPWVAVCAGVILVLMLL 559
+++ C C + G C+ VDL + L + G + V +LL
Sbjct: 1316 LNKFQCLCDVAFAGERCE------------VDLADDLISD------IFTTIGSVTVALLL 1357
Query: 560 LGCAAVVVCV 569
+ A+V V
Sbjct: 1358 ILLLAIVASV 1367
Score = 156 bits (394), Expect = 7e-38
Identities = 76/202 (37%), Positives = 104/202 (51%), Gaps = 11/202 (5%)
Query: 289 LNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLEN 348
LN C + PC +G C + SY CSC G++G CEL IDEC +PC +G +C+D
Sbjct: 1140 LNVCNSN-PCLHGGNCEDI-YSSYHCSCPLGWSGKHCELNIDECFSNPCIHG-NCSDRVA 1196
Query: 349 SYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKK--- 405
+Y CTC PG+ G CE+ C C NG C S GYSC C ++G C +
Sbjct: 1197 AYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCI-SHTNGYSCLCFGNFTGKFCRQSRLP 1255
Query: 406 IDYCSSSP----CSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDG 461
C + C NG C + C C+ GF+G C+ ++D+CAS PC NGG C+D
Sbjct: 1256 STVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDL 1315
Query: 462 VNDFSCTCPPGYTGRNCSAPVS 483
+N F C C + G C ++
Sbjct: 1316 LNKFQCLCDVAFAGERCEVDLA 1337
Score = 131 bits (329), Expect = 3e-30
Identities = 71/200 (35%), Positives = 95/200 (47%), Gaps = 26/200 (13%)
Query: 221 CTEPICLPGCDEQHGFCD---KPGECKCRVGWQGRYC----DECIRYPGCLHGTCQQ--- 270
C CL G G C+ C C +GW G++C DEC P C+HG C
Sbjct: 1143 CNSNPCLHG-----GNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNP-CIHGNCSDRVA 1196
Query: 271 PWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGI- 329
+ C C+ G+ G+ C D++ C H+ C NGATC + G Y+C C +TG C
Sbjct: 1197 AYHCTCEPGYTGVNCEVDIDNCQSHQ-CANGATCISHTNG-YSCLCFGNFTGKFCRQSRL 1254
Query: 330 ------DECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSD 383
+E C NGG+CT+ + C C PGF G+ CE CA PC NGG C D
Sbjct: 1255 PSTVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQD 1314
Query: 384 SPDGGYSCRCPVGYSGFNCE 403
+ + C C V ++G CE
Sbjct: 1315 LLN-KFQCLCDVAFAGERCE 1333
Score = 114 bits (285), Expect = 3e-25
Identities = 56/174 (32%), Positives = 74/174 (42%), Gaps = 3/174 (1%)
Query: 363 CELSAMTCADGPCFNGGRCSD-SPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCV 421
C + C C N C D S D SC +C+ D C S+PC A CV
Sbjct: 27 CNKNNTRCLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSATCV 86
Query: 422 DLGD--AYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCS 479
+ ++LC+C G+SG C+ + C + C +GG C C CP GY GR C
Sbjct: 87 NTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRFCE 146
Query: 480 APVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVDLT 533
C +PC NGA C + Y C C GY G +C + E P + T
Sbjct: 147 IDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPCKNEAT 200
Score = 57.0 bits (136), Expect = 6e-08
Identities = 27/75 (36%), Positives = 38/75 (50%), Gaps = 1/75 (1%)
Query: 445 DDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYV 504
+ C S+PC NGG C +DFSC+CP +G+ C V C +PC +GA C +
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGFE 947
Query: 505 CECARGYGGPNCQFL 519
C + G + Q L
Sbjct: 948 CIANAVFNGQSGQIL 962
Score = 56.6 bits (135), Expect = 8e-08
Identities = 27/70 (38%), Positives = 38/70 (54%), Gaps = 2/70 (2%)
Query: 369 TCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYL 428
+C PC NGG C D +SC CP SG CE+ + +C SPC +GA+C + +
Sbjct: 890 SCKSNPCHNGGVCHSRWDD-FSCSCPALTSGKACEE-VQWCGFSPCPHGAQCQPVLQGFE 947
Query: 429 CRCQAGFSGR 438
C A F+G+
Sbjct: 948 CIANAVFNGQ 957
Score = 53.9 bits (128), Expect = 5e-07
Identities = 24/69 (34%), Positives = 35/69 (50%), Gaps = 1/69 (1%)
Query: 409 CSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCT 468
C S+PC NG C D + C C A SG+ C++ V C SPC +G C+ + F C
Sbjct: 891 CKSNPCHNGGVCHSRWDDFSCSCPALTSGKACEE-VQWCGFSPCPHGAQCQPVLQGFECI 949
Query: 469 CPPGYTGRN 477
+ G++
Sbjct: 950 ANAVFNGQS 958
Score = 49.7 bits (117), Expect = 1e-05
Identities = 24/72 (33%), Positives = 34/72 (47%), Gaps = 2/72 (2%)
Query: 328 GIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDG 387
G + C +PC NGG C + +SC+CP GK CE C PC +G +C
Sbjct: 887 GDNSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQ- 944
Query: 388 GYSCRCPVGYSG 399
G+ C ++G
Sbjct: 945 GFECIANAVFNG 956
Score = 41.2 bits (95), Expect = 0.003
Identities = 20/65 (30%), Positives = 30/65 (46%), Gaps = 2/65 (3%)
Query: 297 PCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPP 356
PC NG C ++ ++CSC +G CE + C SPC +G C + + C
Sbjct: 895 PCHNGGVC-HSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGFECIANA 952
Query: 357 GFYGK 361
F G+
Sbjct: 953 VFNGQ 957
Score = 38.1 bits (87), Expect = 0.029
Identities = 14/39 (35%), Positives = 23/39 (58%), Gaps = 1/39 (2%)
Query: 402 CEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHC 440
C +K D+C S PC + +C++L +Y C C + G +C
Sbjct: 670 CVRK-DWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
Score = 36.6 bits (83), Expect = 0.084
Identities = 14/32 (43%), Positives = 16/32 (50%)
Query: 485 CEHAPCHNGATCHERGHRYVCECARGYGGPNC 516
CE PC + C Y C+C R Y GPNC
Sbjct: 676 CESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
Score = 33.5 bits (75), Expect = 0.71
Identities = 13/34 (38%), Positives = 18/34 (52%)
Query: 330 DECDPSPCKNGGSCTDLENSYSCTCPPGFYGKIC 363
D C+ PC++ G C +L SY C C + G C
Sbjct: 674 DWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
Score = 31.2 bits (69), Expect = 3.5
Identities = 13/34 (38%), Positives = 16/34 (47%)
Query: 445 DDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNC 478
D C S PC + G C + + C C Y G NC
Sbjct: 674 DWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 236 bits (603), Expect = 4e-62
Identities = 99/221 (44%), Positives = 125/221 (56%), Gaps = 2/221 (0%)
Query: 297 PCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPP 356
PC N TC G+G Y C C GYTG CE IDEC P PC N G C DL + C CP
Sbjct: 1201 PCHNSGTCQQLGRG-YVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPS 1259
Query: 357 GFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSN 416
G+ G+ CE + C+ PC N G C D GY C C G+ G +CE +++ C S+PC N
Sbjct: 1260 GYTGQRCEENINECSSSPCLNKGICVDGV-AGYRCTCVKGFVGLHCETEVNECQSNPCLN 1318
Query: 417 GAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGR 476
A C D +LC+C GF G C NVD+C S PC NG TC+DG N F C C G+TG
Sbjct: 1319 NAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGS 1378
Query: 477 NCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQ 517
+C ++ C+ PC N ATC + + Y C+C G+ G C+
Sbjct: 1379 HCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCE 1419
Score = 216 bits (549), Expect = 8e-56
Identities = 102/246 (41%), Positives = 129/246 (52%), Gaps = 6/246 (2%)
Query: 241 GECKCRVGWQGRYCDECIRYPGCLHGTCQQ---PWQCNCQEGWGGLFCNQDLNYCTHHKP 297
G K R + EC P GTCQQ + C C G+ GL C D++ C+ P
Sbjct: 1181 GHIKKRHEISSQVFHECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSP-LP 1239
Query: 298 CKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPG 357
C N C + G + C C GYTG CE I+EC SPC N G C D Y CTC G
Sbjct: 1240 CLNNGVCKDL-VGEFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKG 1298
Query: 358 FYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNG 417
F G CE C PC N C D GG+ C+CP G+ G C K +D C S PC NG
Sbjct: 1299 FVGLHCETEVNECQSNPCLNNAVCEDQV-GGFLCKCPPGFLGTRCGKNVDECLSQPCKNG 1357
Query: 418 AKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRN 477
A C D +++ C C AGF+G HC+ N+++C S+PC N TC D +N +SC C PG++G+
Sbjct: 1358 ATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKR 1417
Query: 478 CSAPVS 483
C S
Sbjct: 1418 CETEQS 1423
Score = 192 bits (488), Expect = 9e-49
Identities = 85/197 (43%), Positives = 105/197 (53%), Gaps = 1/197 (0%)
Query: 331 ECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYS 390
EC +PC N G+C L Y C CP G+ G CE C+ PC N G C D G +
Sbjct: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLV-GEFI 1254
Query: 391 CRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASS 450
C CP GY+G CE+ I+ CSSSPC N CVD Y C C GF G HC+ V++C S+
Sbjct: 1255 CECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSN 1314
Query: 451 PCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARG 510
PC N C D V F C CPPG+ G C V C PC NGATC + + + C CA G
Sbjct: 1315 PCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAG 1374
Query: 511 YGGPNCQFLLPELPPGP 527
+ G +C+ + E P
Sbjct: 1375 FTGSHCELNINECQSNP 1391
Score = 119 bits (298), Expect = 1e-26
Identities = 79/232 (34%), Positives = 106/232 (45%), Gaps = 36/232 (15%)
Query: 164 HSSGRTD-LKYSYRFVCDEHYYGEGCSVF---CRPRD--------DAFGHFTC------- 204
H+SG L Y +C Y G C C P D G F C
Sbjct: 1203 HNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYT 1262
Query: 205 GERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCD----ECIRY 260
G+R E+ N P + IC+ G G+ C C G+ G +C+ EC
Sbjct: 1263 GQRCEENINECSSSPCLNKGICVDGVA---GY-----RCTCVKGFVGLHCETEVNECQSN 1314
Query: 261 PGCLHGTCQQP---WQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCR 317
P + C+ + C C G+ G C ++++ C +PCKNGATC + G S+ C C
Sbjct: 1315 PCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLS-QPCKNGATCKD-GANSFRCLCA 1372
Query: 318 PGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMT 369
G+TG+ CEL I+EC +PC+N +C D NSYSC C PGF GK CE T
Sbjct: 1373 AGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQST 1424
Score = 117 bits (294), Expect = 3e-26
Identities = 73/223 (32%), Positives = 98/223 (43%), Gaps = 37/223 (16%)
Query: 203 TCGERGEK---VCNPGWKGPYCTEPI--CLPGCDEQHGFC-DKPGE--CKCRVGWQGRYC 254
TC + G +C G+ G C I C P +G C D GE C+C G+ G+ C
Sbjct: 1207 TCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGQRC 1266
Query: 255 DE----CIRYPGCLHGTCQQP---WQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNT 307
+E C P G C ++C C +G+ GL C ++N C + PC N A C +
Sbjct: 1267 EENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSN-PCLNNAVCEDQ 1325
Query: 308 GQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSA 367
G + C C PG+ G C +DEC PCKNG +C D NS+ C C GF G CEL+
Sbjct: 1326 -VGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNI 1384
Query: 368 MTCADGPC--------------------FNGGRCSDSPDGGYS 390
C PC F+G RC G++
Sbjct: 1385 NECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQSTGFN 1427
Score = 114 bits (285), Expect = 3e-25
Identities = 44/121 (36%), Positives = 66/121 (54%)
Query: 409 CSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCT 468
C +PC N C LG Y+C C G++G C+ ++D+C+ PC N G C+D V +F C
Sbjct: 1197 CFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICE 1256
Query: 469 CPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPA 528
CP GYTG+ C ++ C +PC N C + Y C C +G+ G +C+ + E P
Sbjct: 1257 CPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPC 1316
Query: 529 V 529
+
Sbjct: 1317 L 1317
Score = 78.2 bits (191), Expect = 3e-14
Identities = 82/311 (26%), Positives = 118/311 (37%), Gaps = 45/311 (14%)
Query: 245 CRVG--WQGRYCDECI--RYPGCLHGTCQQPWQCNCQEGWGGLFCNQ-DLNYCTHHKPCK 299
CR G +GR C C Y H TC+ + Q+ G L C T + +
Sbjct: 988 CRPGSVLRGRMCVNCPLGTYYNLEHFTCESCRIGSYQDEEGQLECKLCPSGMYTEYIHSR 1047
Query: 300 NGATC-TNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGF 358
N + C QG+Y+ S G++ C+ P G+ S SC P
Sbjct: 1048 NISDCKAQCKQGTYSYS------------GLETCESCPL---GTYQPKFGSRSCLSCPEN 1092
Query: 359 YGKI----CELSA--MTCADG--------PCFNGGRCSDSPDGG--YSCRCPV-GYSGFN 401
+ +SA + C +G PC R P+ G + CP G + F
Sbjct: 1093 TSTVKRGAVNISACGVPCPEGKFSRSGLMPCHPCPRDYYQPNAGKAFCLACPFYGTTPFA 1152
Query: 402 CEKKIDYCSS-SPCSNGAKCVDLGDAYLCRCQAGFSGRH--CDDNVDDCASSPCANGGTC 458
+ I CSS S + A+ + A L + RH +C +PC N GTC
Sbjct: 1153 GSRSITECSSFSSTFSAAEESVVPPASLGHIKK----RHEISSQVFHECFFNPCHNSGTC 1208
Query: 459 RDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQF 518
+ + C CP GYTG C + C PC N C + ++CEC GY G C+
Sbjct: 1209 QQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEE 1268
Query: 519 LLPELPPGPAV 529
+ E P +
Sbjct: 1269 NINECSSSPCL 1279
Score = 77.8 bits (190), Expect = 3e-14
Identities = 39/114 (34%), Positives = 49/114 (42%), Gaps = 10/114 (8%)
Query: 213 NPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCDECIRYPGCLH-GTCQQP 271
N W P +C C + G C +P C C GW GR C+E I CL+ G C P
Sbjct: 3459 NGTWTSPPICRAVCRFPC-QNGGICQRPNACSCPEGWMGRLCEEPICILPCLNGGRCVAP 3517
Query: 272 WQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATC 325
+QC+C GW G C+ PC NG C + C C +TG C
Sbjct: 3518 YQCDCPPGWTGSRCHT----AVCQSPCLNGGKCVRPNR----CHCLSSWTGHNC 3563
Score = 77.0 bits (188), Expect = 6e-14
Identities = 39/105 (37%), Positives = 53/105 (50%), Gaps = 16/105 (15%)
Query: 336 PCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPV 395
PC+NGG C + +C+CP G+ G++CE PC NGGRC Y C CP
Sbjct: 3475 PCQNGGIC---QRPNACSCPEGWMGRLCEEPICIL---PCLNGGRCV----APYQCDCPP 3524
Query: 396 GYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHC 440
G++G C + SPC NG KCV C C + ++G +C
Sbjct: 3525 GWTGSRCHTAV---CQSPCLNGGKCV---RPNRCHCLSSWTGHNC 3563
Score = 72.0 bits (175), Expect = 2e-12
Identities = 39/116 (33%), Positives = 49/116 (42%), Gaps = 14/116 (12%)
Query: 254 CDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYT 313
C R+P G CQ+P C+C EGW G C + + PC NG C Y
Sbjct: 3468 CRAVCRFPCQNGGICQRPNACSCPEGWMGRLCEEPICIL----PCLNGGRCV----APYQ 3519
Query: 314 CSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMT 369
C C PG+TG+ C + + SPC NGG C C C + G C T
Sbjct: 3520 CDCPPGWTGSRCHTAVCQ---SPCLNGGKCV---RPNRCHCLSSWTGHNCSRKRRT 3569
Score = 71.6 bits (174), Expect = 2e-12
Identities = 41/109 (37%), Positives = 50/109 (45%), Gaps = 17/109 (15%)
Query: 297 PCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPP 356
PC+NG C Q CSC G+ G CE I PC NGG C Y C CPP
Sbjct: 3475 PCQNGGIC----QRPNACSCPEGWMGRLCEEPICIL---PCLNGGRCVA---PYQCDCPP 3524
Query: 357 GFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKK 405
G+ G C + PC NGG+C P+ C C ++G NC +K
Sbjct: 3525 GWTGSRCHTAV---CQSPCLNGGKCV-RPN---RCHCLSSWTGHNCSRK 3566
Score = 70.9 bits (172), Expect = 4e-12
Identities = 43/106 (40%), Positives = 51/106 (48%), Gaps = 16/106 (15%)
Query: 374 PCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQA 433
PC NGG C P+ +C CP G+ G CE+ I PC NG +CV Y C C
Sbjct: 3475 PCQNGGICQ-RPN---ACSCPEGWMGRLCEEPICIL---PCLNGGRCVA---PYQCDCPP 3524
Query: 434 GFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCS 479
G++G C V SPC NGG C V C C +TG NCS
Sbjct: 3525 GWTGSRCHTAV---CQSPCLNGGKC---VRPNRCHCLSSWTGHNCS 3564
Score = 68.2 bits (165), Expect = 3e-11
Identities = 39/104 (37%), Positives = 49/104 (47%), Gaps = 15/104 (14%)
Query: 413 PCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPG 472
PC NG C C C G+ GR C++ + PC NGG C V + C CPPG
Sbjct: 3475 PCQNGGICQRPN---ACSCPEGWMGRLCEEPI---CILPCLNGGRC---VAPYQCDCPPG 3525
Query: 473 YTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNC 516
+TG C V + +PC NG C R +R C C + G NC
Sbjct: 3526 WTGSRCHTAVCQ---SPCLNGGKC-VRPNR--CHCLSSWTGHNC 3563
Score = 63.2 bits (152), Expect = 8e-10
Identities = 29/77 (37%), Positives = 38/77 (49%), Gaps = 2/77 (2%)
Query: 212 CNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCDECIRYPGCLH-GTCQQ 270
C GW G C EPIC+ C G C P +C C GW G C + CL+ G C +
Sbjct: 3490 CPEGWMGRLCEEPICILPC-LNGGRCVAPYQCDCPPGWTGSRCHTAVCQSPCLNGGKCVR 3548
Query: 271 PWQCNCQEGWGGLFCNQ 287
P +C+C W G C++
Sbjct: 3549 PNRCHCLSSWTGHNCSR 3565
Score = 40.8 bits (94), Expect = 0.004
Identities = 34/109 (31%), Positives = 52/109 (47%), Gaps = 16/109 (14%)
Query: 414 CSNGAKCVDLGDAYL-CRCQAGFSG--RHCDDNVDDCA-SSPCANGGTCRDGVNDFSCTC 469
C+NG LGD+ + C ++G C D VD+CA S C+ +C + + C+C
Sbjct: 1716 CNNGYYL--LGDSRMFCTDNGSWNGVSPSCLD-VDECAVGSDCSEHASCLNVDGSYICSC 1772
Query: 470 PPGYT--GRNCSAPVSRCEHAP-----CHNGATCHERGHRYVCECARGY 511
P YT G+NC+ P+ +C+ AP H+ + G C GY
Sbjct: 1773 VPPYTGDGKNCAEPI-KCK-APGNPENGHSSGEIYTVGAEVTFSCQEGY 1819
Score = 38.1 bits (87), Expect = 0.029
Identities = 34/146 (23%), Positives = 51/146 (34%), Gaps = 32/146 (21%)
Query: 282 GLFCNQDLNYCTHHKPCKNGATCTN--------TGQGSYTCSCRPGYTGATCEL------ 327
G F D+ +C++ C G C + T G + C C GY G +
Sbjct: 267 GSFIQDDMVHCSYL--CDEGKDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACP 324
Query: 328 -----------GIDECDPSPCKNGGSCTDLENSYSCTCPPGF--YGKICEL---SAMTCA 371
GI C P P +N S + C C G+ G+ CEL A+
Sbjct: 325 SGTYKPEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPP 384
Query: 372 DGPCFNGGRCSDSPDGGYSCRCPVGY 397
+ F C++ + RC G+
Sbjct: 385 ENGYFIQNTCNNHFNAACGVRCHPGF 410
Score = 37.0 bits (84), Expect = 0.064
Identities = 53/207 (25%), Positives = 67/207 (32%), Gaps = 49/207 (23%)
Query: 325 CELGIDECDP-SPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGR--- 380
C+ G D CD CK C + C C G+YGK + C G G
Sbjct: 281 CDEGKDCCDRMGSCK----CGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGG 336
Query: 381 ------CSD----SPDGGYS---CRCPVGY--SGFNCEKKIDYCSS-SPCSNGAKCVDLG 424
C D SP G S C C GY SG CE + +C + P NG
Sbjct: 337 ISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCE--LVHCPALKPPENGY------ 388
Query: 425 DAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPG--YTGRNCSAPV 482
F C+++ + C G D V C P ++G V
Sbjct: 389 ----------FIQNTCNNHFNAACGVRCHPG---FDLVGSSIILCLPNGLWSGSESYCRV 435
Query: 483 SRCEH--APCHNGATCHERGHRYVCEC 507
C H P H +C R Y C
Sbjct: 436 RTCPHLRQPKHGHISCSTREMLYKTTC 462
Score = 37.0 bits (84), Expect = 0.064
Identities = 35/136 (25%), Positives = 46/136 (33%), Gaps = 40/136 (29%)
Query: 230 CDEQHGFCDKPGECKCRV-----------GWQGR-------------YCDE--------C 257
CDE CD+ G CKC G+ G+ Y E C
Sbjct: 281 CDEGKDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGGISSC 340
Query: 258 IRYPGCLHGT---CQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTC 314
I P H + P C C+EG+ +L +C KP +NG NT +
Sbjct: 341 IPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNA 400
Query: 315 SCRPGYTGATCELGID 330
+C G C G D
Sbjct: 401 AC-----GVRCHPGFD 411
Score = 36.6 bits (83), Expect = 0.084
Identities = 41/165 (24%), Positives = 57/165 (34%), Gaps = 28/165 (16%)
Query: 298 CKNGATCTNTGQGSYTCSCRPGYTGATCE-LGIDECDP-SPCKNGGSCTDLENSYSCTCP 355
C NG G C+ + G + L +DEC S C SC +++ SY C+C
Sbjct: 1716 CNNGYYLL--GDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSCV 1773
Query: 356 PGFY--GKICELSAMTCADGPCFNGGRCSDSPDGG--YSCRCPVGYSGFNCEK------- 404
P + GK C A G NG + G + C GY K
Sbjct: 1774 PPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESG 1833
Query: 405 ----KIDYCSSSPCSNGA----KCVD-----LGDAYLCRCQAGFS 436
I YC + C A C++ G RC G++
Sbjct: 1834 EWNHLIPYCKAVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYT 1878
Score = 33.5 bits (75), Expect = 0.71
Identities = 32/129 (24%), Positives = 51/129 (39%), Gaps = 30/129 (23%)
Query: 334 PSPCKNGGSCTD---LENSYSCTCPPGFYGKICELSAMTCADGPCFNG--GRCSDSPDGG 388
P P +NG D ++ + C G+Y + S M C D +NG C D +
Sbjct: 1693 PPPLENGFHSADDFYAGSTVTYQCNNGYY--LLGDSRMFCTDNGSWNGVSPSCLDVDE-- 1748
Query: 389 YSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFS--GRHCDDNVDD 446
C VG S CS A C+++ +Y+C C ++ G++C + +
Sbjct: 1749 ----CAVG---------------SDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKC 1789
Query: 447 CASSPCANG 455
A NG
Sbjct: 1790 KAPGNPENG 1798
Score = 31.6 bits (70), Expect = 2.7
Identities = 54/256 (21%), Positives = 83/256 (32%), Gaps = 73/256 (28%)
Query: 175 YRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTE---PICLPGCD 231
+ +C++ YYG+G C C G P + C+P D
Sbjct: 303 FECICEKGYYGKGLQYEC-----------------TACPSGTYKPEGSPGGISSCIPCPD 345
Query: 232 EQHGF---CDKPGECKCRVGWQ--GRYCDECIRYPGC--------LHGTCQQPWQC---- 274
E H P +C CR G++ G+ C E + P + TC +
Sbjct: 346 ENHTSPPGSTSPEDCVCREGYRASGQTC-ELVHCPALKPPENGYFIQNTCNNHFNAACGV 404
Query: 275 NCQEG----------------WGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSY--TC-- 314
C G W G + C H + K+G +T + Y TC
Sbjct: 405 RCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLV 464
Query: 315 SCRPGY-----TGATCELGIDECDPSPCKNGGSCTDLE-------NSYSCTCPPGFYGKI 362
+C GY TC+ P P C+ + + ++C P +G I
Sbjct: 465 ACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTI 524
Query: 363 CELSAMTCADGPCFNG 378
C +S C G +G
Sbjct: 525 CYVS---CRQGFILSG 537
>gi|55770876 notch4 preproprotein [Homo sapiens]
Length = 2003
Score = 230 bits (586), Expect = 4e-60
Identities = 140/421 (33%), Positives = 173/421 (41%), Gaps = 63/421 (14%)
Query: 175 YRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPG--CDE 232
Y C Y G CS A C G CNP G YCT P G C
Sbjct: 713 YNCTCPTGYTGPTCS----EEMTACHSGPCLNGGS--CNPSPGGYYCTCPPSHTGPQCQT 766
Query: 233 QHGFC------------DKPG--ECKCRVGWQGRYCDECIRYPGCLHGTCQ--------- 269
+C ++PG C C +G+QG C+ +R P C C+
Sbjct: 767 STDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLR-PSCADSPCRNRATCQDSP 825
Query: 270 QPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGI 329
Q +C C G+ G C ++ C KPC + C TG S+ C C G+TG C L +
Sbjct: 826 QGPRCLCPTGYTGGSCQTLMDLCAQ-KPCPRNSHCLQTGP-SFHCLCLQGWTGPLCNLPL 883
Query: 330 DECDP----------SPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGG 379
C S C NGG C D SY C CPPGF G +C+ C PC NG
Sbjct: 884 SSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVNPCESRPCQNGA 943
Query: 380 RCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRH 439
C P G Y C+C GY G NC K++D C S PC N C + C C GF G
Sbjct: 944 TCMAQPSG-YLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLR 1002
Query: 440 CDDNVDDCASSPCANGGT--CRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCH 497
C+ +VD+C PC GT C N F C C PG+TG+ C + C PC +G TC
Sbjct: 1003 CEGDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCE 1062
Query: 498 ERGHR---YVCECARGYGGPNCQFLLPE------------LP-PGPAVVDLTEKLEGQGG 541
++C C +G+ GP C P LP P P L G GG
Sbjct: 1063 ATAGSPLGFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGG 1122
Query: 542 P 542
P
Sbjct: 1123 P 1123
Score = 227 bits (578), Expect = 3e-59
Identities = 133/404 (32%), Positives = 178/404 (44%), Gaps = 44/404 (10%)
Query: 160 SQDLH-SSGRTDLKYSYRFVCDEHYYGEGCSVFCRPRDDA--FGHFTCGER---GEKVCN 213
SQ H S DL ++ +C G+ C V A H C + + +C
Sbjct: 481 SQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICL 540
Query: 214 PGWKGPYCTEPI--CLPGCDEQHGFC-DKPG--ECKCRVGWQGRYC----DECIRYPGCL 264
PG+ G C E I C G C D+PG CKC G++G C DEC+ P +
Sbjct: 541 PGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECLSDPCPV 600
Query: 265 HGTCQQ---PWQCNCQEGWGGLFCNQDL---NYCTHHKPCKN------------------ 300
+C + C C G+ G C L N C + CK+
Sbjct: 601 GASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAP 660
Query: 301 ---GATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPG 357
TC + +C C G+TG CE + C +PC +GG+C + Y+CTCP G
Sbjct: 661 PEDNCTCHHGHCQRSSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTG 720
Query: 358 FYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNG 417
+ G C C GPC NGG C+ SP GGY C CP ++G C+ DYC S+PC NG
Sbjct: 721 YTGPTCSEEMTACHSGPCLNGGSCNPSP-GGYYCTCPPSHTGPQCQTSTDYCVSAPCFNG 779
Query: 418 AKCVDLGDAYLCRCQAGFSGRHCDDNV-DDCASSPCANGGTCRDGVNDFSCTCPPGYTGR 476
CV+ + C C GF G C+ + CA SPC N TC+D C CP GYTG
Sbjct: 780 GTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGG 839
Query: 477 NCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLL 520
+C + C PC + C + G + C C +G+ GP C L
Sbjct: 840 SCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPL 883
Score = 226 bits (576), Expect = 6e-59
Identities = 128/403 (31%), Positives = 178/403 (44%), Gaps = 75/403 (18%)
Query: 197 DAFGHFTCGERGEKVCNPGWKGPYCTEPI--CLPGCDEQHGFCDKPGE-------CKCRV 247
+ G F C +C G +GP C C P G C E C C
Sbjct: 213 NTLGSFQC------LCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPP 266
Query: 248 GWQGRYC----DECIRYPGCLHGTCQQ---PWQCNCQEGWGGLFCNQDLNYCTHHKP--C 298
G+ G C D C+ + GTCQ + C C E W G C++D++ C P C
Sbjct: 267 GFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHC 326
Query: 299 KNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGF 358
+NG TC N+ GS+ C C G+ G +CE +D+C + C G +C D S+SC CPPG
Sbjct: 327 RNGGTCQNSA-GSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGR 385
Query: 359 YGKICELSAM--------------------------------TC------------ADGP 374
G +C L M TC P
Sbjct: 386 TGLLCHLEDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSP 445
Query: 375 CFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAG 434
C +GG C ++P G ++C CP GY+G CE + C S PC G+ C+DL + C C G
Sbjct: 446 CEHGGSCLNTP-GSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPG 504
Query: 435 FSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGA 494
G+ C+ ++CAS+PC N C D +N F C C PG++G C + C +PC NG
Sbjct: 505 LEGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGG 564
Query: 495 TCHERGHRYVCECARGYGGPNCQFLLPE-----LPPGPAVVDL 532
C ++ + C+C G+ GP CQ + E P G + +DL
Sbjct: 565 QCQDQPGAFHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDL 607
Score = 223 bits (567), Expect = 6e-58
Identities = 122/363 (33%), Positives = 162/363 (44%), Gaps = 61/363 (16%)
Query: 200 GHFTCGERGEKVCNPGWKGPYC--------TEPICLPGC---DEQHGFCDKPGECKCRVG 248
G F C +C PG+ G C ++P C PG D F C C G
Sbjct: 457 GSFNC------LCPPGYTGSRCEADHNECLSQP-CHPGSTCLDLLATF-----HCLCPPG 504
Query: 249 WQGRYCD----ECIRYPGCLHGTCQQ---PWQCNCQEGWGGLFCNQDLNYCTHHKPCKNG 301
+G+ C+ EC P H C +QC C G+ G C +D++ C PC NG
Sbjct: 505 LEGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDEC-RSSPCANG 563
Query: 302 ATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGK 361
C + G++ C C PG+ G C+ +DEC PC G SC DL ++ C CP GF G+
Sbjct: 564 GQCQDQ-PGAFHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQ 622
Query: 362 ICELSAMTCADGPCFNGGRCSDS--------PDGG-------------------YSCRCP 394
+CE+ CA C C D PDG SC C
Sbjct: 623 LCEVPL--CAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCVCD 680
Query: 395 VGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCAN 454
VG++G CE ++ C S+PC++G C Y C C G++G C + + C S PC N
Sbjct: 681 VGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCLN 740
Query: 455 GGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGP 514
GG+C + CTCPP +TG C C APC NG TC R + C CA G+ GP
Sbjct: 741 GGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGP 800
Query: 515 NCQ 517
C+
Sbjct: 801 RCE 803
Score = 221 bits (564), Expect = 1e-57
Identities = 142/457 (31%), Positives = 187/457 (40%), Gaps = 115/457 (25%)
Query: 174 SYRFVCDEHYYGEGCSV-----------FCRPR---DDAFGHFTCGERGEKVCNPGWKGP 219
+Y +C E + G CS CR ++ G F C VC GW G
Sbjct: 297 TYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHC------VCVSGWGGT 350
Query: 220 YCTEPI-------CLPG--CDEQHGFCDKPGECKCRVGWQGRYC---DECIRYPGCLHGT 267
C E + C PG C ++ G C C G G C D C+ P HG
Sbjct: 351 SCEENLDDCIAATCAPGSTCIDRVGSFS----CLCPPGRTGLLCHLEDMCLSQP--CHGD 404
Query: 268 CQQPWQ-------CNCQEGWGGLFCNQDLNYCTHHK----PCKNGATCTNTGQGSYTCSC 316
Q C CQ G+ G C+QDL+ C + PC++G +C NT GS+ C C
Sbjct: 405 AQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNT-PGSFNCLC 463
Query: 317 RPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCF 376
PGYTG+ CE +EC PC G +C DL ++ C CPPG G++CE+ CA PC
Sbjct: 464 PPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECASAPCL 523
Query: 377 NGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFS 436
N C D +G + C C G+SG CE+ ID C SSPC+NG +C D A+ C+C GF
Sbjct: 524 NHADCHDLLNG-FQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFE 582
Query: 437 GRHCDDNVDD------------------------------------CASSPCANGGTCRD 460
G C VD+ CA + C C+D
Sbjct: 583 GPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKD 642
Query: 461 GVNDFSCTCPPG----------------------------YTGRNCSAPVSRCEHAPCHN 492
+ +C CP G +TG C A + C APC +
Sbjct: 643 QKDKANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCVCDVGWTGPECEAELGGCISAPCAH 702
Query: 493 GATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAV 529
G TC+ + Y C C GY GP C + GP +
Sbjct: 703 GGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCL 739
Score = 214 bits (546), Expect = 2e-55
Identities = 131/398 (32%), Positives = 168/398 (42%), Gaps = 63/398 (15%)
Query: 166 SGRTDLKYSYRFVCDEHYYGEGCSV---------FCRPRDDAFGHFTCGERGEKVCNPGW 216
S + L S+ C + GE C FC R H R + C PGW
Sbjct: 92 SSPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRC--HIQASGRPQCSCMPGW 149
Query: 217 KGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNC 276
G C + FC + C+ CL QC+C
Sbjct: 150 TGEQC----------QLRDFCS---------------ANPCVNGGVCL--ATYPQIQCHC 182
Query: 277 QEGWGGLFCNQDLNYCTHHK-PCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPS 335
G+ G C +D+N C PC G +C NT GS+ C C G G CEL C P
Sbjct: 183 PPGFEGHACERDVNECFQDPGPCPKGTSCHNT-LGSFQCLCPVGQEGPRCELRAGPCPPR 241
Query: 336 PCKNGGSCTDLENSYS----CTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSC 391
C NGG+C + S C CPPGF G CE++ C C NGG C D D Y+C
Sbjct: 242 GCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLD-TYTC 300
Query: 392 RCPVGYSGFNCEKKIDYCSSS---PCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCA 448
CP ++G++C + +D C + C NG C + ++ C C +G+ G C++N+DDC
Sbjct: 301 LCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCI 360
Query: 449 SSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATC--HERGHRYVCE 506
++ CA G TC D V FSC CPPG TG C C PCH A C + +C
Sbjct: 361 AATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLE-DMCLSQPCHGDAQCSTNPLTGSTLCL 419
Query: 507 CARGYGGPNCQFLLPELPPGPAVVDLTEKLEGQGGPFP 544
C GY GP C DL E L Q GP P
Sbjct: 420 CQPGYSGPTCH------------QDLDECLMAQQGPSP 445
Score = 205 bits (522), Expect = 1e-52
Identities = 127/415 (30%), Positives = 169/415 (40%), Gaps = 71/415 (17%)
Query: 200 GHFTCGERGEKVCNPGWKGPYCT---EPICLPGCDEQHGFC-DKPG--ECKCRVGWQGRY 253
G F+C +C G++GP C P C C D P C C G+ G
Sbjct: 787 GTFSC------LCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGS 840
Query: 254 C----DECIRYPGCLHGTCQQP---WQCNCQEGWGGLFCNQDLNYCTH---------HKP 297
C D C + P + C Q + C C +GW G CN L+ C
Sbjct: 841 CQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSL 900
Query: 298 CKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPG 357
C NG C ++G SY C C PG+ G+ C+ ++ C+ PC+NG +C + Y C C PG
Sbjct: 901 CHNGGLCVDSGP-SYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPG 959
Query: 358 FYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPC--S 415
+ G+ C C PC N G C+ P GG+ C CP G+ G CE +D C PC +
Sbjct: 960 YDGQNCSKELDACQSQPCHNHGTCTPKP-GGFHCACPPGFVGLRCEGDVDECLDQPCHPT 1018
Query: 416 NGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVND---FSCTCPPG 472
A C L +A+ C+C G +G+ C+ +D C S PC +GGTC F C CP G
Sbjct: 1019 GTAACHSLANAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLGFICHCPKG 1078
Query: 473 YTGRNCSAPVSRCEHAPCHNGATC---HERGHRYVCEC---------------------- 507
+ G CS C CH+G C + G C C
Sbjct: 1079 FEGPTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTPPAPKGCGPPS 1138
Query: 508 ----------ARGYGGPNCQFLLPELPPGPAVVDLTEK-LEGQGGPFPWVAVCAG 551
G GGP + P PGP K EG+ G A C+G
Sbjct: 1139 PCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQKPGAKGCEGRSGDGACDAGCSG 1193
Score = 163 bits (413), Expect = 5e-40
Identities = 83/244 (34%), Positives = 114/244 (46%), Gaps = 24/244 (9%)
Query: 296 KPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSP-CKNGGSC----------- 343
+PC NG TC + G TC C PG+ G TC+ D C + C+NGGSC
Sbjct: 33 EPCANGGTCLSLSLGQGTCQCAPGFLGETCQFP-DPCQNAQLCQNGGSCQALLPAPLGLP 91
Query: 344 ---TDLENSYSCTCPPGFYGKICELSAM-TCADGPCFNGGRCSDSPDGGYSCRCPVGYSG 399
+ L S+ CTC PGF G+ C+ C C GRC G C C G++G
Sbjct: 92 SSPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTG 151
Query: 400 FNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCAS--SPCANGGT 457
C+ + D+CS++PC NG C+ C C GF G C+ +V++C PC G +
Sbjct: 152 EQCQLR-DFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPKGTS 210
Query: 458 CRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHR----YVCECARGYGG 513
C + + F C CP G G C C C NG TC + ++C C G+ G
Sbjct: 211 CHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIG 270
Query: 514 PNCQ 517
P+C+
Sbjct: 271 PDCE 274
Score = 131 bits (329), Expect = 3e-30
Identities = 108/368 (29%), Positives = 138/368 (37%), Gaps = 62/368 (16%)
Query: 212 CNPGWKGPYCTE---PICLPGCDEQHGFCDKPGE--CKCRVGWQGRYC----DECIRYPG 262
C PG++G C + P C +P C+C G+ G+ C D C P
Sbjct: 918 CPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPC 977
Query: 263 CLHGTCQQP---WQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPG 319
HGTC + C C G+ GL C D++ C G ++ ++ C C PG
Sbjct: 978 HNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAFYCQCLPG 1037
Query: 320 YTGATCELGIDECDPSPCKNGGSCTDLENS---YSCTCPPGFYGKICELSAMTCADGPCF 376
+TG CE+ ID C PC +GG+C S + C CP GF G C A +C C
Sbjct: 1038 HTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRAPSCGFHHCH 1097
Query: 377 NGGRCSDSPDGGY--SCRCPVGYSGFNC--EKKIDYCS-SSPCSNGAKCVDL----GDAY 427
+GG C SP G+ C C GY G +C C SPC C + G +
Sbjct: 1098 HGGLCLPSPKPGFPPRCACLSGYGGPDCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPGF 1157
Query: 428 LC---------RCQ----AGFSGRHCDDNVDDCASSPCAN--GGTCRDGVNDFSCTCP-- 470
C RCQ G GR D D S P N GG C GV D CP
Sbjct: 1158 RCSCPHSSPGPRCQKPGAKGCEGRSGDGACDAGCSGPGGNWDGGDCSLGVPDPWKGCPSH 1217
Query: 471 -------------PGYTGRNCSAPVSRCEHAPCHNGA---TCHERGHRYVCE-----CAR 509
P C CE P A CH+ H CE
Sbjct: 1218 SRCWLLFRDGQCHPQCDSEECLFDGYDCETPPACTPAYDQYCHDHFHNGHCEKGCNTAEC 1277
Query: 510 GYGGPNCQ 517
G+ G +C+
Sbjct: 1278 GWDGGDCR 1285
Score = 129 bits (324), Expect = 1e-29
Identities = 70/210 (33%), Positives = 92/210 (43%), Gaps = 19/210 (9%)
Query: 334 PSPCKNGGSCTDLE-NSYSCTCPPGFYGKICELSAMTCADGPCFNGGRC----------- 381
P PC NGG+C L +C C PGF G+ C+ C NGG C
Sbjct: 32 PEPCANGGTCLSLSLGQGTCQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAPLGLP 91
Query: 382 -SDSP-DGGYSCRCPVGYSGFNCEKKI-DYCSSSPCSNGAKC-VDLGDAYLCRCQAGFSG 437
S SP + C C G++G C+ K+ D C S CS +C + C C G++G
Sbjct: 92 SSPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTG 151
Query: 438 RHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRC--EHAPCHNGAT 495
C D C+++PC NGG C C CPPG+ G C V+ C + PC G +
Sbjct: 152 EQCQLR-DFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPKGTS 210
Query: 496 CHERGHRYVCECARGYGGPNCQFLLPELPP 525
CH + C C G GP C+ PP
Sbjct: 211 CHNTLGSFQCLCPVGQEGPRCELRAGPCPP 240
Score = 38.5 bits (88), Expect = 0.022
Identities = 103/447 (23%), Positives = 143/447 (31%), Gaps = 95/447 (21%)
Query: 212 CNPGWKGPYCTEPICLPGCDEQH----GFC---DKPG---ECKCRVGWQGRYCDECIRYP 261
C G++GP C+ P C H G C KPG C C G+ G C
Sbjct: 1075 CPKGFEGPTCSHRA--PSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTPPAPK 1132
Query: 262 GC-------LHGTCQQP-------WQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNT 307
GC +G+C + ++C+C G C KP G +
Sbjct: 1133 GCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQ---------KPGAKGCE-GRS 1182
Query: 308 GQGSYTCSCR-PG--YTGATCELGIDECDPSPCKN------------GGSCTD------- 345
G G+ C PG + G C LG+ P P K G C
Sbjct: 1183 GDGACDAGCSGPGGNWDGGDCSLGV----PDPWKGCPSHSRCWLLFRDGQCHPQCDSEEC 1238
Query: 346 LENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKK 405
L + Y C PP + +G C G ++ G CR G +
Sbjct: 1239 LFDGYDCETPPACTPAYDQYCHDHFHNGHCEKGCNTAECGWDGGDCRPEDGDPEWGPSLA 1298
Query: 406 IDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDF 465
+ S P + + L + G R D D P A G D
Sbjct: 1299 LLVVLSPPALD-QQLFALARVLSLTLRVGLWVRKDRDGRDMVYPYPGARAEEKLGGTRDP 1357
Query: 466 SC-------TCPPGYTGRNCSA--------PVSRCEHAPCHNGATCH-ERGHRYVCECAR 509
+ T P G + SA +SRC P H + C + G A
Sbjct: 1358 TYQERAAPQTQPLGKETDSLSAGFVVVMGVDLSRC--GPDHPASRCPWDPGLLLRFLAAM 1415
Query: 510 GYGGPNCQFLLPELPPGPAVVDLTEKLEGQGGP---FPWVAVCAGVILVLMLLLGCAAVV 566
G L L PGP + G P PW +C+ V V++L LG V+
Sbjct: 1416 AAVGA-----LEPLLPGPLLA--VHPHAGTAPPANQLPWPVLCSPVAGVILLALGALLVL 1468
Query: 567 VCVRLRLQKH----RPPADPCRGETET 589
+R R ++H PP R T++
Sbjct: 1469 QLIRRRRREHGALWLPPGFTRRPRTQS 1495
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 226 bits (575), Expect = 7e-59
Identities = 101/235 (42%), Positives = 133/235 (56%), Gaps = 12/235 (5%)
Query: 297 PCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENS---YSCT 353
PC+N TC N Y C+C GY G CE+ +D C PC+NGG+C E ++C+
Sbjct: 933 PCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCS 992
Query: 354 CPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSS-- 411
CP GF G C ++ C D C NGG C D G Y+C+CP+ Y G CE+ +D CS
Sbjct: 993 CPTGFEGPTCGVNTDDCVDHACANGGVCVDGV-GNYTCQCPLQYEGKACEQLVDLCSPDL 1051
Query: 412 SPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPP 471
+PC + A+CV D C C G++G +C +N DDC C NG C D VN +SC C
Sbjct: 1052 NPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAE 1111
Query: 472 GYTGRNCS------APVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLL 520
GY+G+ C AP S CE C NGA C ++G+R VC+C G+GGP C+ LL
Sbjct: 1112 GYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEKLL 1166
Score = 169 bits (428), Expect = 8e-42
Identities = 88/244 (36%), Positives = 121/244 (49%), Gaps = 16/244 (6%)
Query: 254 CDECIRYPGCLHGTCQ----QPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATC-TNTG 308
CD C+ P GTC + ++C C G+ G C L+ C+ PC+NG TC G
Sbjct: 926 CDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSG-PCENGGTCHAQEG 984
Query: 309 QGS-YTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSA 367
+ + +TCSC G+ G TC + D+C C NGG C D +Y+C CP + GK CE
Sbjct: 985 EDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLV 1044
Query: 368 MTCAD--GPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGD 425
C+ PC + +C +PDG C C GY+G NC + D C C NGA+C+D +
Sbjct: 1045 DLCSPDLNPCQHEAQCVGTPDGP-RCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVN 1103
Query: 426 AYLCRCQAGFSGRHCD------DNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCS 479
+Y C C G+SG+ C+ C + C NG C D N C C PG+ G C
Sbjct: 1104 SYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECE 1163
Query: 480 APVS 483
+S
Sbjct: 1164 KLLS 1167
Score = 144 bits (364), Expect = 2e-34
Identities = 84/239 (35%), Positives = 110/239 (46%), Gaps = 25/239 (10%)
Query: 225 ICLPGCDEQHGFC-DKPGE---CKCRVGWQGRYC----DECIRYPGCLHGTC------QQ 270
+CL + G C + P E C C G++GR C D C P GTC
Sbjct: 928 LCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDA 987
Query: 271 PWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGID 330
P+ C+C G+ G C + + C H C NG C + G G+YTC C Y G CE +D
Sbjct: 988 PFTCSCPTGFEGPTCGVNTDDCVDH-ACANGGVCVD-GVGNYTCQCPLQYEGKACEQLVD 1045
Query: 331 ECDP--SPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGG 388
C P +PC++ C + C C PG+ G C + C D C NG +C D +
Sbjct: 1046 LCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVN-S 1104
Query: 389 YSCRCPVGYSGFNCE------KKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCD 441
YSC C GYSG CE C + C NGA CVD G+ +C+C GF G C+
Sbjct: 1105 YSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECE 1163
Score = 142 bits (359), Expect = 8e-34
Identities = 86/258 (33%), Positives = 104/258 (40%), Gaps = 50/258 (19%)
Query: 326 ELGIDEC-DPSPCKNGGSCTDLENSYSCTCPPGFYGKI-CELSAMTCADGPCFNGGRCSD 383
E GI C P + T + C PP + C+L C PC N G C +
Sbjct: 887 EPGIARCAGPQDMEGKLLLTTPAKKFECQGPPTLAVQAKCDL----CLSSPCQNQGTCHN 942
Query: 384 SPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKC-VDLGD--AYLCRCQAGFSGRHC 440
P Y C CP GY G +CE +D CSS PC NG C G+ + C C GF G C
Sbjct: 943 DPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTC 1002
Query: 441 DDNVDDCASSPCANGGTCRDGVNDFSCTCP------------------------------ 470
N DDC CANGG C DGV +++C CP
Sbjct: 1003 GVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVG 1062
Query: 471 ----------PGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLL 520
PGY G NCS C C NGA C + + Y C CA GY G C+ +
Sbjct: 1063 TPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCE-IP 1121
Query: 521 PELPPGPAVVDLTEKLEG 538
P LP + + TE G
Sbjct: 1122 PHLPAPKSPCEGTECQNG 1139
Score = 117 bits (294), Expect = 3e-26
Identities = 70/215 (32%), Positives = 93/215 (43%), Gaps = 24/215 (11%)
Query: 212 CNPGWKGPYCTEPI--CLPGCDEQHGFC------DKPGECKCRVGWQGRYC----DECIR 259
C G+KG C + C G E G C D P C C G++G C D+C+
Sbjct: 952 CPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVD 1011
Query: 260 YPGCLHGTCQQ---PWQCNCQEGWGGLFCNQDLNYCTHH-KPCKNGATCTNTGQGSYTCS 315
+ G C + C C + G C Q ++ C+ PC++ A C T G C
Sbjct: 1012 HACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGP-RCE 1070
Query: 316 CRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICEL------SAMT 369
C PGY G C D+C C+NG C D NSYSC C G+ G++CE+
Sbjct: 1071 CMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSP 1130
Query: 370 CADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEK 404
C C NG C D + C+C G+ G CEK
Sbjct: 1131 CEGTECQNGANCVDQGNRPV-CQCLPGFGGPECEK 1164
Score = 75.1 bits (183), Expect = 2e-13
Identities = 41/118 (34%), Positives = 54/118 (45%), Gaps = 9/118 (7%)
Query: 254 CDECIRYPGCLHGTCQQPW----QCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQ 309
C+ C R CLHG CQ C+C+ GW GL C+Q + H C +G C
Sbjct: 1339 CEPC-RKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHG-QCVPLDA 1396
Query: 310 GSYTCSCRPGYTGATCELG---IDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICE 364
SY+C C+ GY+GA C + C C +G C C PGF G++CE
Sbjct: 1397 LSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCE 1454
Score = 66.2 bits (160), Expect = 1e-10
Identities = 43/139 (30%), Positives = 59/139 (42%), Gaps = 26/139 (18%)
Query: 223 EPICLPGCDE------QHGFCDK---PGE-CKCRVGWQGRYCDECIRYP----GCLHGTC 268
+P +PGC+ HG C PG C C GW G +CD+ P C+HG C
Sbjct: 1332 KPGVVPGCEPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQC 1391
Query: 269 ----QQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKN----GATCTNTGQGSYTCSCRPGY 320
+ C CQ+G+ G CNQ +PC+ C +G C C PG+
Sbjct: 1392 VPLDALSYSCQCQDGYSGALCNQAGALA---EPCRGLQCLHGHCQASGTKGAHCVCDPGF 1448
Query: 321 TGATCELGIDECDPSPCKN 339
+G CE EC P ++
Sbjct: 1449 SGELCEQE-SECRGDPVRD 1466
Score = 52.8 bits (125), Expect = 1e-06
Identities = 43/165 (26%), Positives = 58/165 (35%), Gaps = 12/165 (7%)
Query: 328 GIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNG----GRCSD 383
G + C C +G + C C G+ G C+ A DGPC G+C
Sbjct: 1338 GCEPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPA----DGPCHGHKCVHGQCVP 1393
Query: 384 SPDGGYSCRCPVGYSGFNCEKK---IDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHC 440
YSC+C GYSG C + + C C +G C C GFSG C
Sbjct: 1394 LDALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELC 1453
Query: 441 DDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRC 485
+ +C P + + G T P + S P C
Sbjct: 1454 EQE-SECRGDPVRDFHQVQRGYAICQTTRPLSWVECRGSCPGQGC 1497
Score = 42.0 bits (97), Expect = 0.002
Identities = 27/81 (33%), Positives = 31/81 (38%), Gaps = 5/81 (6%)
Query: 465 FSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHR-YVCECARGYGGPNCQFLLPEL 523
F C PP A C +PC N TCH Y C C GY G +C+ L
Sbjct: 912 FECQGPPTLA---VQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSC 968
Query: 524 PPGPAVVDLT-EKLEGQGGPF 543
GP T EG+ PF
Sbjct: 969 SSGPCENGGTCHAQEGEDAPF 989
Score = 35.8 bits (81), Expect = 0.14
Identities = 20/77 (25%), Positives = 27/77 (35%), Gaps = 9/77 (11%)
Query: 445 DDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHER----- 499
+ C C +G + C C G+ G +C P PCH H +
Sbjct: 1340 EPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPAD----GPCHGHKCVHGQCVPLD 1395
Query: 500 GHRYVCECARGYGGPNC 516
Y C+C GY G C
Sbjct: 1396 ALSYSCQCQDGYSGALC 1412
>gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens]
Length = 383
Score = 225 bits (574), Expect = 1e-58
Identities = 98/236 (41%), Positives = 129/236 (54%), Gaps = 6/236 (2%)
Query: 211 VCNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQ 270
+C G G C CD HG C G C+C GW+G +C+ C+R PGC HGTC Q
Sbjct: 14 LCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQHGTCHQ 73
Query: 271 PWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGID 330
PWQC C GW G FC++D + CT PC+NG C G G Y C C PG+ G CE
Sbjct: 74 PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAG 133
Query: 331 ECDP--SPCKNGGSCTDLEN---SYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSP 385
C+ SPC+NGG C D + +++C C GF G CE++ C PC NG C D
Sbjct: 134 PCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGI 193
Query: 386 DGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCD 441
+ +SC CP G++G C +D C+S PC GA+C D + C C +G+ G+ C+
Sbjct: 194 N-RFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
Score = 192 bits (489), Expect = 7e-49
Identities = 98/246 (39%), Positives = 123/246 (50%), Gaps = 19/246 (7%)
Query: 292 CTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYS 351
C+ H +G C G +C C PG+ G CE C P G+C +
Sbjct: 29 CSSHCDLAHGC-CAPDG----SCRCDPGWEGLHCE----RCVRMPGCQHGTC---HQPWQ 76
Query: 352 CTCPPGFYGKICELSAMTCA-DGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYC- 409
C C G+ GK C+ C PC NGG+C G Y C C G+ G +CE+K C
Sbjct: 77 CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCE 136
Query: 410 -SSSPCSNGAKCVD---LGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDF 465
+ SPC NG +C D + CRC GF G C+ NVDDC PCANG TC DG+N F
Sbjct: 137 QAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRF 196
Query: 466 SCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPP 525
SC CP G+ GR C+ + C PC GA C +R H + C C GYGG C+ +LP +P
Sbjct: 197 SCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLP-VPD 255
Query: 526 GPAVVD 531
P VD
Sbjct: 256 PPTTVD 261
Score = 169 bits (427), Expect = 1e-41
Identities = 85/231 (36%), Positives = 114/231 (49%), Gaps = 22/231 (9%)
Query: 186 EGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKC 245
+ CS C H C G C+PGW+G +C + +PGC QHG C +P +C C
Sbjct: 27 DDCSSHCD-----LAHGCCAPDGSCRCDPGWEGLHCERCVRMPGC--QHGTCHQPWQCIC 79
Query: 246 RVGWQGRYCDE----CIRYPGCLH-GTCQQ----PWQCNCQEGWGGLFCNQDLNYCTH-H 295
GW G++CD+ C C + G C + C C G+ G C + C
Sbjct: 80 HSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAG 139
Query: 296 KPCKNGATCTNTGQG---SYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSC 352
PC+NG C + QG ++TC C G+ GA CE+ +D+C PC NG +C D N +SC
Sbjct: 140 SPCRNGGQCQD-DQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSC 198
Query: 353 TCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCE 403
CP GF G+ C ++ CA PC G RC D + C CP GY G CE
Sbjct: 199 LCPEGFAGRFCTINLDDCASRPCQRGARCRDRVH-DFDCLCPSGYGGKTCE 248
>gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens]
Length = 383
Score = 225 bits (574), Expect = 1e-58
Identities = 98/236 (41%), Positives = 129/236 (54%), Gaps = 6/236 (2%)
Query: 211 VCNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQ 270
+C G G C CD HG C G C+C GW+G +C+ C+R PGC HGTC Q
Sbjct: 14 LCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQHGTCHQ 73
Query: 271 PWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGID 330
PWQC C GW G FC++D + CT PC+NG C G G Y C C PG+ G CE
Sbjct: 74 PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAG 133
Query: 331 ECDP--SPCKNGGSCTDLEN---SYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSP 385
C+ SPC+NGG C D + +++C C GF G CE++ C PC NG C D
Sbjct: 134 PCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGI 193
Query: 386 DGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCD 441
+ +SC CP G++G C +D C+S PC GA+C D + C C +G+ G+ C+
Sbjct: 194 N-RFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCE 248
Score = 192 bits (489), Expect = 7e-49
Identities = 98/246 (39%), Positives = 123/246 (50%), Gaps = 19/246 (7%)
Query: 292 CTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYS 351
C+ H +G C G +C C PG+ G CE C P G+C +
Sbjct: 29 CSSHCDLAHGC-CAPDG----SCRCDPGWEGLHCE----RCVRMPGCQHGTC---HQPWQ 76
Query: 352 CTCPPGFYGKICELSAMTCA-DGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYC- 409
C C G+ GK C+ C PC NGG+C G Y C C G+ G +CE+K C
Sbjct: 77 CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCE 136
Query: 410 -SSSPCSNGAKCVD---LGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDF 465
+ SPC NG +C D + CRC GF G C+ NVDDC PCANG TC DG+N F
Sbjct: 137 QAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRF 196
Query: 466 SCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPP 525
SC CP G+ GR C+ + C PC GA C +R H + C C GYGG C+ +LP +P
Sbjct: 197 SCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLP-VPD 255
Query: 526 GPAVVD 531
P VD
Sbjct: 256 PPTTVD 261
Score = 169 bits (427), Expect = 1e-41
Identities = 85/231 (36%), Positives = 114/231 (49%), Gaps = 22/231 (9%)
Query: 186 EGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKC 245
+ CS C H C G C+PGW+G +C + +PGC QHG C +P +C C
Sbjct: 27 DDCSSHCD-----LAHGCCAPDGSCRCDPGWEGLHCERCVRMPGC--QHGTCHQPWQCIC 79
Query: 246 RVGWQGRYCDE----CIRYPGCLH-GTCQQ----PWQCNCQEGWGGLFCNQDLNYCTH-H 295
GW G++CD+ C C + G C + C C G+ G C + C
Sbjct: 80 HSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAG 139
Query: 296 KPCKNGATCTNTGQG---SYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSC 352
PC+NG C + QG ++TC C G+ GA CE+ +D+C PC NG +C D N +SC
Sbjct: 140 SPCRNGGQCQD-DQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSC 198
Query: 353 TCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCE 403
CP GF G+ C ++ CA PC G RC D + C CP GY G CE
Sbjct: 199 LCPEGFAGRFCTINLDDCASRPCQRGARCRDRVH-DFDCLCPSGYGGKTCE 248
>gi|116235485 delta-notch-like EGF repeat-containing transmembrane
[Homo sapiens]
Length = 737
Score = 224 bits (572), Expect = 2e-58
Identities = 125/362 (34%), Positives = 173/362 (47%), Gaps = 37/362 (10%)
Query: 226 CLPG--------CDEQHGFCDKPGE----CKCRVGWQGRYCDECIRYPGCLHGTCQQP-- 271
C+PG C + KP E C C + G +C+E Y C CQ
Sbjct: 307 CVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEE---YDACQRKPCQNNAS 363
Query: 272 ------------WQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPG 319
+ C C G+ G C ++YC PC+NGATC ++ G +TC C G
Sbjct: 364 CIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILD-PCRNGATCISSLSG-FTCQCPEG 421
Query: 320 YTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGG 379
Y G+ CE +D C SPC+N G+C ++C C PGF G C CA PC +G
Sbjct: 422 YFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG- 480
Query: 380 RCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRH 439
S Y C C GY G CE++ + C S+PC N A C DL + Y C C A + G H
Sbjct: 481 -TCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTH 539
Query: 440 CDDNVDDCASSPCANGGTC-RDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHE 498
C+ D CA+ C NG TC DG+N +C C PG+TG C ++ C+ PCH+G +C +
Sbjct: 540 CELYKDPCANVSCLNGATCDSDGLNG-TCICAPGFTGEECDIDINECDSNPCHHGGSCLD 598
Query: 499 RGHRYVCECARGYGGPNCQFLLPELPPGPAVVDLTEKLEGQGGPFPWVAVCAGVILVLML 558
+ + Y C C G+ G NC+ L + G LT + A+C IL+L++
Sbjct: 599 QPNGYNCHCPHGWVGANCEIHL-QWKSGHMAESLT-NMPRHSLYIIIGALCVAFILMLII 656
Query: 559 LL 560
L+
Sbjct: 657 LI 658
Score = 160 bits (405), Expect = 4e-39
Identities = 80/202 (39%), Positives = 105/202 (51%), Gaps = 10/202 (4%)
Query: 323 ATCELGIDECDPSPCKNGGSCT--DLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGR 380
+TC G + C G CT E ++SCTC + G CE C PC N
Sbjct: 305 STCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDACQRKPCQNNAS 363
Query: 381 CSDSPD----GGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFS 436
C D+ + ++C C GY+G C+ KIDYC PC NGA C+ + C+C G+
Sbjct: 364 CIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYF 423
Query: 437 GRHCDDNVDDCASSPCANGGTCR-DGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGAT 495
G C++ VD CASSPC N GTC DGV+ F+C C PG+TG C+ + C +PC +G T
Sbjct: 424 GSACEEKVDPCASSPCQNNGTCYVDGVH-FTCNCSPGFTGPTCAQLIDFCALSPCAHG-T 481
Query: 496 CHERGHRYVCECARGYGGPNCQ 517
C G Y C C GY G C+
Sbjct: 482 CRSVGTSYKCLCDPGYHGLYCE 503
Score = 100 bits (248), Expect = 6e-21
Identities = 62/196 (31%), Positives = 85/196 (43%), Gaps = 42/196 (21%)
Query: 179 CDEHYYGEGCSV---FCRPRDDAFGHFTCGERGEK---VCNPGWKGPYCTEPICLPGCDE 232
C + G C+ FC A G TC G +C+PG+ G YC E
Sbjct: 456 CSPGFTGPTCAQLIDFCALSPCAHG--TCRSVGTSYKCLCDPGYHGLYCEEEY------- 506
Query: 233 QHGFCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQ---QPWQCNCQEGWGGLFCNQDL 289
+EC+ P TC+ ++C C + G C
Sbjct: 507 ----------------------NECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYK 544
Query: 290 NYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENS 349
+ C + C NGATC + G TC C PG+TG C++ I+ECD +PC +GGSC D N
Sbjct: 545 DPCA-NVSCLNGATCDSDGLNG-TCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNG 602
Query: 350 YSCTCPPGFYGKICEL 365
Y+C CP G+ G CE+
Sbjct: 603 YNCHCPHGWVGANCEI 618
Score = 77.0 bits (188), Expect = 6e-14
Identities = 36/93 (38%), Positives = 44/93 (47%), Gaps = 15/93 (16%)
Query: 447 CASSPCANGGTCRD------------GVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNG- 493
CA+ PC NGG C G +SCTCP G +G NC C PCH+G
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
Query: 494 --ATCHERGHRYVCECARGYGGPNCQFLLPELP 524
++ Y+C C GY GPNC+ LP LP
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQALPSLP 140
Score = 72.4 bits (176), Expect = 1e-12
Identities = 37/89 (41%), Positives = 42/89 (47%), Gaps = 14/89 (15%)
Query: 332 CDPSPCKNGGSCTDL------------ENSYSCTCPPGFYGKICELSAMTCADGPCFNG- 378
C PC+NGG CT E YSCTCP G G C+L A CA PC +G
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
Query: 379 -GRCSDSPDGGYSCRCPVGYSGFNCEKKI 406
S S GY C C GY G NCE+ +
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQAL 136
Score = 72.0 bits (175), Expect = 2e-12
Identities = 34/86 (39%), Positives = 44/86 (51%), Gaps = 14/86 (16%)
Query: 370 CADGPCFNGGRCSDSPDG-----------GYSCRCPVGYSGFNCEKKIDYCSSSPCSNG- 417
CA PC NGG C+ P+ GYSC CP G SG NC+ D C+S+PC +G
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
Query: 418 --AKCVDLGDAYLCRCQAGFSGRHCD 441
+ D YLC C G+ G +C+
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133
Score = 60.8 bits (146), Expect = 4e-09
Identities = 28/83 (33%), Positives = 41/83 (49%), Gaps = 14/83 (16%)
Query: 296 KPCKNGATCTN-----------TGQGSYTCSCRPGYTGATCELGIDECDPSPCKNG---G 341
+PC+NG CT+ G+ Y+C+C G +GA C+L D C +PC +G
Sbjct: 51 QPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSS 110
Query: 342 SCTDLENSYSCTCPPGFYGKICE 364
S + + Y C C G+ G CE
Sbjct: 111 SSSSSSDGYLCICNEGYEGPNCE 133
Score = 57.4 bits (137), Expect = 5e-08
Identities = 46/162 (28%), Positives = 65/162 (40%), Gaps = 39/162 (24%)
Query: 174 SYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQ 233
SY+ +CD Y+G C E+ N P C D
Sbjct: 488 SYKCLCDPGYHGLYC--------------------EEEYNECLSAPCLNAATCR---DLV 524
Query: 234 HGFCDKPGECKCRVGWQGRYC----DECIRYPGCLHG-TCQQP---WQCNCQEGWGGLFC 285
+G+ EC C ++G +C D C CL+G TC C C G+ G C
Sbjct: 525 NGY-----ECVCLAEYKGTHCELYKDPCANV-SCLNGATCDSDGLNGTCICAPGFTGEEC 578
Query: 286 NQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCEL 327
+ D+N C + PC +G +C + G Y C C G+ GA CE+
Sbjct: 579 DIDINECDSN-PCHHGGSCLDQPNG-YNCHCPHGWVGANCEI 618
Score = 42.0 bits (97), Expect = 0.002
Identities = 40/144 (27%), Positives = 51/144 (35%), Gaps = 43/144 (29%)
Query: 163 LHSSGRTDLKYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCT 222
L+++ DL Y VC Y G C ++ P C
Sbjct: 515 LNAATCRDLVNGYECVCLAEYKGTHCELYKDP--------------------------CA 548
Query: 223 EPICLPGCDEQHGFCDKP---GECKCRVGWQGRYCD----ECIRYPGCLH-GTC-QQP-- 271
CL G CD G C C G+ G CD EC P C H G+C QP
Sbjct: 549 NVSCLNGAT-----CDSDGLNGTCICAPGFTGEECDIDINECDSNP-CHHGGSCLDQPNG 602
Query: 272 WQCNCQEGWGGLFCNQDLNYCTHH 295
+ C+C GW G C L + + H
Sbjct: 603 YNCHCPHGWVGANCEIHLQWKSGH 626
Score = 38.5 bits (88), Expect = 0.022
Identities = 35/111 (31%), Positives = 41/111 (36%), Gaps = 27/111 (24%)
Query: 205 GERGEKVCNP------GWKGPYCTEP-----ICL--PGCDEQHGF-CDKPG-ECKCRVGW 249
G RG + NP GP +P +C P D QH +PG C C G
Sbjct: 27 GPRGSSLANPVPAAPLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGI 86
Query: 250 QGRYC----DECIRYPGCLHGTCQQP-------WQCNCQEGWGGLFCNQDL 289
G C D C P C HG C + C C EG+ G C Q L
Sbjct: 87 SGANCQLVADPCASNP-CHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQAL 136
>gi|74136023 delta-like 1 homolog [Homo sapiens]
Length = 383
Score = 224 bits (571), Expect = 2e-58
Identities = 102/249 (40%), Positives = 135/249 (54%), Gaps = 26/249 (10%)
Query: 198 AFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCDEC 257
AFGH T G C P C+ Q+GFC+ C+C+ GWQG CD+C
Sbjct: 16 AFGHSTYGAE------------------CFPACNPQNGFCEDDNVCRCQPGWQGPLCDQC 57
Query: 258 IRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCR 317
+ PGCLHG C +P QC C +GW G C++D+ C+ PC N TC + G Y CSC
Sbjct: 58 VTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACS-SAPCANNGTCVSLDDGLYECSCA 116
Query: 318 PGYTGATCELGIDEC--DPSPCKNGGSCTDLE---NSYSCTCPPGFYGKICELSAMTCAD 372
PGY+G C+ C + SPC++GG+C D E + SC CPPGF G CE+ A +C
Sbjct: 117 PGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTP 176
Query: 373 GPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGD-AYLCRC 431
PC N G C+D G + CRCP G+ C + + C+SSPC NG C+ +Y C C
Sbjct: 177 NPCENDGVCTDI-GGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLC 235
Query: 432 QAGFSGRHC 440
+ F+G C
Sbjct: 236 KPEFTGLTC 244
Score = 172 bits (436), Expect = 1e-42
Identities = 89/234 (38%), Positives = 115/234 (49%), Gaps = 19/234 (8%)
Query: 253 YCDECIRYPGC--LHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQG 310
Y EC +P C +G C+ C CQ GW G C+Q C C +G C GQ
Sbjct: 22 YGAEC--FPACNPQNGFCEDDNVCRCQPGWQGPLCDQ----CVTSPGCLHGL-CGEPGQ- 73
Query: 311 SYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENS-YSCTCPPGFYGKICELSAMT 369
C C G+ G C+ + C +PC N G+C L++ Y C+C PG+ GK C+
Sbjct: 74 ---CICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGP 130
Query: 370 CA--DGPCFNGGRCSDSPDGGY--SCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGD 425
C PC +GG C D SC CP G+SG CE + C+ +PC N C D+G
Sbjct: 131 CVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGG 190
Query: 426 AYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVN-DFSCTCPPGYTGRNC 478
+ CRC AGF + C V +CASSPC NGGTC + C C P +TG C
Sbjct: 191 DFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
Score = 162 bits (409), Expect = 1e-39
Identities = 79/209 (37%), Positives = 101/209 (48%), Gaps = 13/209 (6%)
Query: 314 CSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADG 373
C C+PG+ G C D+C SP G C + C C G+ G++C+ C+
Sbjct: 43 CRCQPGWQGPLC----DQCVTSPGCLHGLCGE---PGQCICTDGWDGELCDRDVRACSSA 95
Query: 374 PCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYC--SSSPCSNGAKCVD---LGDAYL 428
PC N G C DG Y C C GYSG +C+KK C + SPC +G CVD
Sbjct: 96 PCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHAS 155
Query: 429 CRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHA 488
C C GFSG C+ + C +PC N G C D DF C CP G+ + CS PV+ C +
Sbjct: 156 CLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASS 215
Query: 489 PCHNGATCHERGH-RYVCECARGYGGPNC 516
PC NG TC + Y C C + G C
Sbjct: 216 PCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
Score = 92.0 bits (227), Expect = 2e-18
Identities = 53/150 (35%), Positives = 73/150 (48%), Gaps = 19/150 (12%)
Query: 391 CRCPVGYSGFNCEKKIDYCSSSP-CSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCAS 449
CRC G+ G C D C +SP C +G G+ C C G+ G CD +V C+S
Sbjct: 43 CRCQPGWQGPLC----DQCVTSPGCLHGL----CGEPGQCICTDGWDGELCDRDVRACSS 94
Query: 450 SPCANGGTC---RDGVNDFSCTCPPGYTGRNCSAPVSRC--EHAPCHNGATCHE---RGH 501
+PCAN GTC DG+ + C+C PGY+G++C C +PC +G TC + R
Sbjct: 95 APCANNGTCVSLDDGL--YECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRAS 152
Query: 502 RYVCECARGYGGPNCQFLLPELPPGPAVVD 531
C C G+ G C+ + P P D
Sbjct: 153 HASCLCPPGFSGNFCEIVANSCTPNPCEND 182
Score = 68.2 bits (165), Expect = 3e-11
Identities = 39/108 (36%), Positives = 47/108 (43%), Gaps = 13/108 (12%)
Query: 425 DAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSR 484
D +CRCQ G+ G CD C +SP G C + C C G+ G C V
Sbjct: 39 DDNVCRCQPGWQGPLCDQ----CVTSPGCLHGLCGE---PGQCICTDGWDGELCDRDVRA 91
Query: 485 CEHAPCHNGATCHERGHR-YVCECARGYGGPNCQFLLPELPPGPAVVD 531
C APC N TC Y C CA GY G +CQ GP V++
Sbjct: 92 CSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQ-----KKDGPCVIN 134
>gi|122937283 6720455I24Rik homolog [Homo sapiens]
Length = 1413
Score = 205 bits (521), Expect = 1e-52
Identities = 109/297 (36%), Positives = 147/297 (49%), Gaps = 26/297 (8%)
Query: 243 CKCRVGWQGRYC----DECIRYPGCLHGTCQQ---PWQCNCQEGWGGLFCNQDLNYCTHH 295
C C G+ GR C +EC P GTC ++C C G+GG C + C
Sbjct: 297 CSCLSGFTGRRCHLDVNECASQPCQNGGTCTHGINSFRCQCPAGFGGPTCETAQSPCDT- 355
Query: 296 KPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCP 355
K C++G C GS C C+ GYTGA CE+ +D+C P PC NGGSC DL +Y+C C
Sbjct: 356 KECQHGGQC-QVENGSAVCVCQAGYTGAACEMDVDDCSPDPCLNGGSCVDLVGNYTCLCA 414
Query: 356 PGFYGKICELSAM----TCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKI-DYCS 410
F G CE C PC NGG C D+ D GY C CP G+ G +C +++ D C
Sbjct: 415 EPFKGLRCETGDHPVPDACLSAPCHNGGTCVDA-DQGYVCECPEGFMGLDCRERVPDDCE 473
Query: 411 SSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCA---SSPCANGGTCRDGVNDFSC 467
C NG +C+ + LC+C GF G C+ + ++ C +GG C + + C
Sbjct: 474 ---CRNGGRCLG-ANTTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLC 529
Query: 468 TCPPGYTGRNCSAPV-SRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPEL 523
C +T N S + S C+ PC NG +C Y CEC RG+ G +C+ P L
Sbjct: 530 VC---HTDHNASHSLPSPCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHL 583
Score = 203 bits (517), Expect = 4e-52
Identities = 98/247 (39%), Positives = 126/247 (51%), Gaps = 11/247 (4%)
Query: 285 CNQDLNYCTHHKPCKNGATCTN---TGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGG 341
C + C +PC NG C + TG SYTCSC G+TG C L ++EC PC+NGG
Sbjct: 265 CGHTTSVCLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGG 324
Query: 342 SCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFN 401
+CT NS+ C CP GF G CE + C C +GG+C +G C C GY+G
Sbjct: 325 TCTHGINSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQC-QVENGSAVCVCQAGYTGAA 383
Query: 402 CEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDN----VDDCASSPCANGGT 457
CE +D CS PC NG CVDL Y C C F G C+ D C S+PC NGGT
Sbjct: 384 CEMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGT 443
Query: 458 CRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQ 517
C D + C CP G+ G +C V + C NG C + +C+C G+ G C+
Sbjct: 444 CVDADQGYVCECPEGFMGLDCRERVP--DDCECRNGGRC-LGANTTLCQCPLGFFGLLCE 500
Query: 518 FLLPELP 524
F + +P
Sbjct: 501 FEITAMP 507
Score = 203 bits (516), Expect = 5e-52
Identities = 149/451 (33%), Positives = 183/451 (40%), Gaps = 80/451 (17%)
Query: 133 DDLATENPERLISRLA----TQRHLTVGEEWSQDLHSSGR-TDLKYSYRFVCDEHYYGEG 187
DD T NP S L+ + HL V E SQ + G T S+R C + G
Sbjct: 286 DDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGGTCTHGINSFRCQCPAGFGGPT 345
Query: 188 CSVF---CRPRDDAFGHFTCGERGEKVC--NPGWKGPYCTEPI--CLPGCDEQHGFC-DK 239
C C ++ G E G VC G+ G C + C P G C D
Sbjct: 346 CETAQSPCDTKECQHGGQCQVENGSAVCVCQAGYTGAACEMDVDDCSPDPCLNGGSCVDL 405
Query: 240 PGE--CKCRVGWQGRYC--------DECIRYPGCLHGTC---QQPWQCNCQEGWGGLFCN 286
G C C ++G C D C+ P GTC Q + C C EG+ GL C
Sbjct: 406 VGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQGYVCECPEGFMGLDCR 465
Query: 287 QDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGI----------------- 329
+ + C+NG C G + C C G+ G CE I
Sbjct: 466 ERV---PDDCECRNGGRCL--GANTTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYC 520
Query: 330 ----------------------DECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELS- 366
CD PC NGGSC ++SY+C CP GF+GK CE +
Sbjct: 521 MEHGGSYLCVCHTDHNASHSLPSPCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKAR 580
Query: 367 AMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCE-KKIDYCSSSPCSNGAKCVDLGD 425
C+ GPC NGG C ++ G Y C CP ++G +CE K D C+S PC NG C
Sbjct: 581 PHLCSSGPCRNGGTCKEA-GGEYHCSCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIG 639
Query: 426 AYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSA----- 480
Y C C GFSGRHC+ C SPC NGGTC D DF C C GY GR C A
Sbjct: 640 KYKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTDFFCHCQAGYMGRRCQAEVDCG 699
Query: 481 PVSRCEHAPCHNGATCHERGHRYVCECARGY 511
P +HA T G + C RGY
Sbjct: 700 PPEEVKHATLRFNGT--RLGAVALYACDRGY 728
Score = 190 bits (483), Expect = 3e-48
Identities = 120/390 (30%), Positives = 163/390 (41%), Gaps = 55/390 (14%)
Query: 192 CRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEP---ICLPGCDEQHGFCDKPG---ECKC 245
C DD++ TC C G+ G +C + +C G G C + G C C
Sbjct: 556 CDAHDDSY---TCE------CPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHCSC 606
Query: 246 RVGWQGRYC-----DECIRYPGCLHGTCQQ---PWQCNCQEGWGGLFCNQDLNYCTHHKP 297
+ GR+C D C P GTC ++C+C G+ G C + C P
Sbjct: 607 PYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPC-FRSP 665
Query: 298 CKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGG-----------SCTDL 346
C NG TC + + C C+ GY G C+ +D P K+ +
Sbjct: 666 CVNGGTCEDRDT-DFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYAC 724
Query: 347 ENSYSCTCPPGFYGKICE-----------LSAMTCADGPCFNGGRCSDSPDGGYSCRCPV 395
+ YS + P ++C+ L C PC +GG C D GY C C
Sbjct: 725 DRGYSLSAPSRI--RVCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRV-AGYLCLCST 781
Query: 396 GYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANG 455
GY G +CE + D C + PC NG C +L AY+CRC AGF G HC+ VD C SSPC +G
Sbjct: 782 GYEGAHCELERDECRAHPCRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHG 841
Query: 456 GTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPN 515
G C G + C CP + G +C C +PC C + C C GY G +
Sbjct: 842 GRCESGGGAYLCVCPESFFGYHCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGED 901
Query: 516 CQFLLPELPPGPAVVDLTEKLEGQGGPFPW 545
C EL P A+ E++E G W
Sbjct: 902 C---AKELFPPTAL--KMERVEESGVSISW 926
Score = 115 bits (289), Expect = 1e-25
Identities = 49/121 (40%), Positives = 64/121 (52%), Gaps = 4/121 (3%)
Query: 413 PCSNGAKCVDL----GDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCT 468
PC NG KC+D +Y C C +GF+GR C +V++CAS PC NGGTC G+N F C
Sbjct: 277 PCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGGTCTHGINSFRCQ 336
Query: 469 CPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPA 528
CP G+ G C S C+ C +G C VC C GY G C+ + + P P
Sbjct: 337 CPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGYTGAACEMDVDDCSPDPC 396
Query: 529 V 529
+
Sbjct: 397 L 397
Score = 51.2 bits (121), Expect = 3e-06
Identities = 27/77 (35%), Positives = 36/77 (46%), Gaps = 17/77 (22%)
Query: 446 DCASSPCANGGTCRDGVNDFSCTCPPGYTGRNC-------SAPVSRC----EHAPCHNGA 494
+C+ +PC NGGTC G + SC C PG+ GR C S P +R + P G
Sbjct: 1310 NCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVWEGG 1369
Query: 495 TCHE------RGHRYVC 505
CH R H+ +C
Sbjct: 1370 VCHHVYKRVYRVHQDIC 1386
Score = 48.5 bits (114), Expect = 2e-05
Identities = 19/44 (43%), Positives = 28/44 (63%), Gaps = 1/44 (2%)
Query: 332 CDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPC 375
C +PC+NGG+C +++SC C PGF G+ CEL+ + PC
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIK-VSRPC 1353
Score = 45.4 bits (106), Expect = 2e-04
Identities = 17/33 (51%), Positives = 20/33 (60%)
Query: 409 CSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCD 441
CS +PC NG CV DA+ C C GF GR C+
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCE 1343
Score = 39.7 bits (91), Expect = 0.010
Identities = 15/31 (48%), Positives = 20/31 (64%), Gaps = 1/31 (3%)
Query: 297 PCKNGATCTNTGQGSYTCSCRPGYTGATCEL 327
PC+NG TC G +++C C PG+ G CEL
Sbjct: 1315 PCQNGGTCV-PGADAHSCDCGPGFKGRRCEL 1344
Score = 37.4 bits (85), Expect = 0.049
Identities = 15/34 (44%), Positives = 19/34 (55%), Gaps = 1/34 (2%)
Query: 370 CADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCE 403
C++ PC NGG C D +SC C G+ G CE
Sbjct: 1311 CSENPCQNGGTCVPGAD-AHSCDCGPGFKGRRCE 1343
Score = 36.2 bits (82), Expect = 0.11
Identities = 13/47 (27%), Positives = 20/47 (42%)
Query: 471 PGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQ 517
P + ++ C PC NG TC + C+C G+ G C+
Sbjct: 1297 PEHGSKDIGNVPGNCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCE 1343
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 199 bits (506), Expect = 7e-51
Identities = 103/294 (35%), Positives = 147/294 (50%), Gaps = 25/294 (8%)
Query: 239 KPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPC 298
+PG +C G D+ + TCQ P N CN L+ PC
Sbjct: 880 EPGIARC--AGPGEMADKLLLTTPSKKFTCQGPVDVNILAK-----CNPCLS-----NPC 927
Query: 299 KNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSC---TDLENSYSCTCP 355
KN TC + Y C+C G+ G C++ I C +PCK+GG+C E+ + C C
Sbjct: 928 KNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDGFWCICA 987
Query: 356 PGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSS--SP 413
GF G+ CE++ C D C N C D + Y+C CP Y+G CE+K+D+C+ +P
Sbjct: 988 DGFEGENCEVNVDDCEDNDCENNSTCVDGINN-YTCLCPPEYTGELCEEKLDFCAQDLNP 1046
Query: 414 CSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGY 473
C + +KC+ + C C G+ G HCD + DDC + C NG C D VN ++C CP GY
Sbjct: 1047 CQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGY 1106
Query: 474 TGRNC--SAPV-----SRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLL 520
+G C S P+ S C++ C NGA C R + +C+C GY G C+ L+
Sbjct: 1107 SGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCEKLV 1160
Score = 171 bits (432), Expect = 3e-42
Identities = 82/245 (33%), Positives = 120/245 (48%), Gaps = 17/245 (6%)
Query: 254 CDECIRYPGCLHGTCQQP----WQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATC--TNT 307
C+ C+ P GTC ++C C G+ G C+ ++ C + PCK+G TC
Sbjct: 919 CNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISN-PCKHGGTCHLKEG 977
Query: 308 GQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSA 367
+ + C C G+ G CE+ +D+C+ + C+N +C D N+Y+C CPP + G++CE
Sbjct: 978 EEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKL 1037
Query: 368 MTCAD--GPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGD 425
CA PC + +C +P G + C C GY G +C+ D C + C NGA C D +
Sbjct: 1038 DFCAQDLNPCQHDSKCILTPKG-FKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVN 1096
Query: 426 AYLCRCQAGFSGRHCD-------DNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNC 478
Y C C G+SG C+ C + C NG C +N+ C C PGY G C
Sbjct: 1097 GYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKC 1156
Query: 479 SAPVS 483
VS
Sbjct: 1157 EKLVS 1161
Score = 162 bits (409), Expect = 1e-39
Identities = 78/221 (35%), Positives = 112/221 (50%), Gaps = 13/221 (5%)
Query: 324 TCELGID-----ECDP---SPCKNGGSC-TDLENSYSCTCPPGFYGKICELSAMTCADGP 374
TC+ +D +C+P +PCKN G+C +D + Y CTCP GF G+ C++ C P
Sbjct: 906 TCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNP 965
Query: 375 CFNGGRC--SDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQ 432
C +GG C + + G+ C C G+ G NCE +D C + C N + CVD + Y C C
Sbjct: 966 CKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCP 1025
Query: 433 AGFSGRHCDDNVDDCAS--SPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPC 490
++G C++ +D CA +PC + C F C C PGY G +C C+ C
Sbjct: 1026 PEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKC 1085
Query: 491 HNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVD 531
NGA C + + Y C C GY G C+F P + P + D
Sbjct: 1086 KNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCD 1126
Score = 75.9 bits (185), Expect = 1e-13
Identities = 63/210 (30%), Positives = 81/210 (38%), Gaps = 34/210 (16%)
Query: 227 LPGCDE------QHGFCDKPGE----CKCRVGWQGRYCDECIRYP----GCLHGTCQQ-- 270
LPGC+ HG C + C+C+ GW G CD+ P C+HGTC
Sbjct: 1330 LPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPIN 1389
Query: 271 --PWQCNCQEGWGGLFCNQD---LNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATC 325
+ C C EG GG+ C+++ N C K CK+G C +G G C C GYTG
Sbjct: 1390 AFSYSCKCLEGHGGVLCDEEEDLFNPCQAIK-CKHG-KCRLSGLGQPYCECSSGYTG--- 1444
Query: 326 ELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAM-TCADGPCFNGGRCSDS 384
D CD G D K+ L CA G C R S
Sbjct: 1445 ----DSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLR---S 1497
Query: 385 PDGGYSCRCPVGYSGFNCEKKIDYCSSSPC 414
YS C G S + +K+ C + C
Sbjct: 1498 KRRKYSFECTDGSSFVDEVEKVVKCGCTRC 1527
Score = 66.6 bits (161), Expect = 8e-11
Identities = 41/148 (27%), Positives = 58/148 (39%), Gaps = 10/148 (6%)
Query: 379 GRCSDSPDGGYSCRCPVGYSGFNCEKKI-DYCSSSPCSNGAKCVDLGDAYLCRCQAGFSG 437
G C S G++C C G+ G C+++ D C + C +G +Y C+C G G
Sbjct: 1344 GTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSCKCLEGHGG 1403
Query: 438 RHCDDNVD---DCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVS------RCEHA 488
CD+ D C + C +G G+ C C GYTG +C +S R +
Sbjct: 1404 VLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREISCRGERIRDYYQ 1463
Query: 489 PCHNGATCHERGHRYVCECARGYGGPNC 516
A C EC G G C
Sbjct: 1464 KQQGYAACQTTKKVSRLECRGGCAGGQC 1491
Score = 65.1 bits (157), Expect = 2e-10
Identities = 49/193 (25%), Positives = 77/193 (39%), Gaps = 25/193 (12%)
Query: 328 GIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAM-TCADGPCFNGGRCSDSPD 386
G + C C +G + ++C C G+ G +C+ C C + G C
Sbjct: 1332 GCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVH-GTCLPINA 1390
Query: 387 GGYSCRCPVGYSGFNCEKKIDY---CSSSPCSNG-AKCVDLGDAYLCRCQAGFSGRHCDD 442
YSC+C G+ G C+++ D C + C +G + LG Y C C +G++G CD
Sbjct: 1391 FSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPY-CECSSGYTGDSCDR 1449
Query: 443 NVDDCASSPCANGGTCR-DGVNDFSCTCPPGYTGRNCSAPVSRCE-HAPCHNGATC---H 497
+ +CR + + D+ GY + VSR E C G C
Sbjct: 1450 EI------------SCRGERIRDY-YQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLR 1496
Query: 498 ERGHRYVCECARG 510
+ +Y EC G
Sbjct: 1497 SKRRKYSFECTDG 1509
Score = 55.8 bits (133), Expect = 1e-07
Identities = 34/124 (27%), Positives = 49/124 (39%), Gaps = 21/124 (16%)
Query: 402 CEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDD-CASSPCANGGTCRD 460
C KK+ C+ C ++ + C CQ G+ G CD +D C + C +G
Sbjct: 1336 CHKKV--CAHGTCQPSSQA-----GFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPI 1388
Query: 461 GVNDFSCTCPPGYTGRNCS--------APVSRCEHAPCHNGATCHERGHRYVCECARGYG 512
+SC C G+ G C +C+H C G Y CEC+ GY
Sbjct: 1389 NAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGL----GQPY-CECSSGYT 1443
Query: 513 GPNC 516
G +C
Sbjct: 1444 GDSC 1447
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 191 bits (484), Expect = 3e-48
Identities = 98/306 (32%), Positives = 144/306 (47%), Gaps = 30/306 (9%)
Query: 240 PGECKCRVGWQGRYCDECIRYPGCLHGTCQQP-------------WQCNCQEGWGGLFCN 286
P C C + W + + PG + +P +QC +G +
Sbjct: 858 PLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPTHRFQC---KGPVDINIV 914
Query: 287 QDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSC--- 343
N C PCKN TCT Y C+C Y G C + I+ C +PC++GG+C
Sbjct: 915 AKCNACLS-SPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLS 973
Query: 344 TDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCE 403
++ +SC+CP GF G+ CE++ C D C N C D + Y C CP Y+G C+
Sbjct: 974 DSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINN-YVCICPPNYTGELCD 1032
Query: 404 KKIDYC--SSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDG 461
+ ID+C + C + AKC+ L + C C G+SG+ C+ + DDC + C +G C D
Sbjct: 1033 EVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDT 1092
Query: 462 VNDFSCTCPPGYTGRNCSAP-------VSRCEHAPCHNGATCHERGHRYVCECARGYGGP 514
+N ++CTCP G++G C P S C+ C NGA C C C G+ GP
Sbjct: 1093 INGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGP 1152
Query: 515 NCQFLL 520
C+ L+
Sbjct: 1153 RCEKLI 1158
Score = 100 bits (248), Expect = 6e-21
Identities = 51/146 (34%), Positives = 69/146 (47%), Gaps = 7/146 (4%)
Query: 384 SPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCV-DLGDAYLCRCQAGFSGRHCDD 442
+P + C+ PV N K + C SSPC N C D + Y C C + G+ C
Sbjct: 898 TPTHRFQCKGPVD---INIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTV 954
Query: 443 NVDDCASSPCANGGTCR--DGVND-FSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHER 499
++ C +PC +GGTC D D FSC+CP G+ G+ C CE C N ATC +
Sbjct: 955 PINTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDG 1014
Query: 500 GHRYVCECARGYGGPNCQFLLPELPP 525
+ YVC C Y G C ++ P
Sbjct: 1015 INNYVCICPPNYTGELCDEVIDHCVP 1040
Score = 69.7 bits (169), Expect = 9e-12
Identities = 42/117 (35%), Positives = 55/117 (47%), Gaps = 20/117 (17%)
Query: 228 PGCDE----QHGFCDKPGE----CKCRVGWQGRYCDECIRYP----GCLHGTC---QQPW 272
PGC +HG C + C+CR GW G CD+ R P C HG C +
Sbjct: 1330 PGCKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTSY 1389
Query: 273 QCNCQEGWGGLFC---NQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCE 326
C C EG+GG C N N C+ K C +G C + QG C C+PG++G C+
Sbjct: 1390 MCKCAEGYGGDLCDNKNDSANACSAFK-CHHG-QCHISDQGEPYCLCQPGFSGEHCQ 1444
Score = 69.7 bits (169), Expect = 9e-12
Identities = 47/165 (28%), Positives = 68/165 (41%), Gaps = 25/165 (15%)
Query: 292 CTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCEL-GIDECDPSPCKNGGSCTDLENSY 350
C CK+G C + + S C CRPG+TG C+ D C C + G C SY
Sbjct: 1332 CKSCTVCKHGL-CRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHH-GKCVATGTSY 1389
Query: 351 SCTCPPGFYGKICEL---SAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKID 407
C C G+ G +C+ SA C+ C + G+C S G C C G+SG +C+++
Sbjct: 1390 MCKCAEGYGGDLCDNKNDSANACSAFKCHH-GQCHISDQGEPYCLCQPGFSGEHCQQE-- 1446
Query: 408 YCSSSPC------------SNGAKCVDLGDAYLCRCQAGFSGRHC 440
+PC A C + C+ G + C
Sbjct: 1447 ----NPCLGQVVREVIRRQKGYASCATASKVPIMECRGGCGPQCC 1487
Score = 56.6 bits (135), Expect = 8e-08
Identities = 35/114 (30%), Positives = 52/114 (45%), Gaps = 9/114 (7%)
Query: 410 SSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNV-DDCASSPCANGGTCRDGVNDFSCT 468
S + C +G D+ +C C+ G++G CD D C C +G G + + C
Sbjct: 1334 SCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTS-YMCK 1392
Query: 469 CPPGYTGRNC---SAPVSRCEHAPCHNGATCH--ERGHRYVCECARGYGGPNCQ 517
C GY G C + + C CH+G CH ++G Y C C G+ G +CQ
Sbjct: 1393 CAEGYGGDLCDNKNDSANACSAFKCHHG-QCHISDQGEPY-CLCQPGFSGEHCQ 1444
Score = 50.8 bits (120), Expect = 4e-06
Identities = 53/177 (29%), Positives = 66/177 (37%), Gaps = 46/177 (25%)
Query: 212 CNPGWKGPYCTEPI---CLPGCDEQHGFCDKPGE---CKCRVGWQGRYCDE-------CI 258
C PGW GP C + CL G HG C G CKC G+ G CD C
Sbjct: 1355 CRPGWTGPLCDQEARDPCL-GHRCHHGKCVATGTSYMCKCAEGYGGDLCDNKNDSANACS 1413
Query: 259 RYPGCLHGTCQ-----QPWQCNCQEGWGGLFCNQDLNYCTHH------KPCKNGATCTNT 307
+ C HG C +P+ C CQ G+ G C Q+ N C + K A+C T
Sbjct: 1414 AFK-CHHGQCHISDQGEPY-CLCQPGFSGEHCQQE-NPCLGQVVREVIRRQKGYASCA-T 1469
Query: 308 GQGSYTCSCRPGYTGATCELGIDECDPS---------PCKNGGS-CTDLENSYSCTC 354
CR G G C C P+ C +G S ++E C C
Sbjct: 1470 ASKVPIMECRGG-CGPQC------CQPTRSKRRKYVFQCTDGSSFVEEVERHLECGC 1519
>gi|209571555 von Willebrand factor D and EGF domains [Homo sapiens]
Length = 1590
Score = 164 bits (414), Expect = 3e-40
Identities = 112/323 (34%), Positives = 140/323 (43%), Gaps = 47/323 (14%)
Query: 202 FTCGERGEKV------CNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCD 255
+ CG+ E V C PG+ G C +C P C + HG C KP C+C G G CD
Sbjct: 1300 YPCGKSRECVAPNICKCKPGYIGSNCQTALCDPDC-KNHGKCIKPNICQCLPGHGGATCD 1358
Query: 256 ECIRYPGCLH-GTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTC 314
E P C H GTC C C G+ G C + C H C+NG C C
Sbjct: 1359 EEHCNPPCQHGGTCLAGNLCTCPYGFVGPRC--ETMVCNRH--CENGGQCLTPD----IC 1410
Query: 315 SCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGP 374
C+PG+ G TC + CDP C NGGSC +C CP GF+G+ C+ P
Sbjct: 1411 QCKPGWYGPTCSTAL--CDP-VCLNGGSC---NKPNTCLCPNGFFGEHCQ---NAFCHPP 1461
Query: 375 CFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAG 434
C NGG C + C C GY+G +K I C + C NG KCV C C +G
Sbjct: 1462 CKNGGHCMRN----NVCVCREGYTGRRFQKSI--CDPT-CMNGGKCV---GPSTCSCPSG 1511
Query: 435 FSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGA 494
+SG+ C N C C NGG C + C CP + G C P+ + C G
Sbjct: 1512 WSGKRC--NTPICLQK-CKNGGEC---IAPSICHCPSSWEGVRCQIPIC---NPKCLYGG 1562
Query: 495 TCHERGHRYVCECARGYGGPNCQ 517
C VC C Y G C+
Sbjct: 1563 RCI---FPNVCSCRTEYSGVKCE 1582
Score = 129 bits (323), Expect = 1e-29
Identities = 95/311 (30%), Positives = 126/311 (40%), Gaps = 38/311 (12%)
Query: 179 CDEHYYGEGC-SVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFC 237
C Y G C + C P D H C + C PG G C E C P C + G C
Sbjct: 1316 CKPGYIGSNCQTALCDP--DCKNHGKCIKPNICQCLPGHGGATCDEEHCNPPC-QHGGTC 1372
Query: 238 DKPGECKCRVGWQGRYCDECIRYPGCLH-GTCQQPWQCNCQEGWGGLFCNQDLNYCTHHK 296
C C G+ G C+ + C + G C P C C+ GW G C+ L C
Sbjct: 1373 LAGNLCTCPYGFVGPRCETMVCNRHCENGGQCLTPDICQCKPGWYGPTCSTAL--C--DP 1428
Query: 297 PCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPP 356
C NG +C TC C G+ G C+ C P PCKNGG C + N+ C C
Sbjct: 1429 VCLNGGSCNKPN----TCLCPNGFFGEHCQNAF--CHP-PCKNGGHC--MRNNV-CVCRE 1478
Query: 357 GFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSN 416
G+ G+ + S D C NGG+C G +C CP G+SG C I C N
Sbjct: 1479 GYTGRRFQKS---ICDPTCMNGGKCV----GPSTCSCPSGWSGKRCNTPI---CLQKCKN 1528
Query: 417 GAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGR 476
G +C+ +C C + + G C + + C GG C + C+C Y+G
Sbjct: 1529 GGECI---APSICHCPSSWEGVRCQIPI---CNPKCLYGGRC---IFPNVCSCRTEYSGV 1579
Query: 477 NCSAPVSRCEH 487
C + H
Sbjct: 1580 KCEKKIQIRRH 1590
Score = 124 bits (311), Expect = 3e-28
Identities = 88/288 (30%), Positives = 122/288 (42%), Gaps = 65/288 (22%)
Query: 259 RYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRP 318
+YP C P C C+ G+ G C L C CKN C C C P
Sbjct: 1299 KYPCGKSRECVAPNICKCKPGYIGSNCQTAL--C--DPDCKNHGKCIKPN----ICQCLP 1350
Query: 319 GYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAM---------- 368
G+ GATC+ + C+P PC++GG+C CTCP GF G CE
Sbjct: 1351 GHGGATCD--EEHCNP-PCQHGGTCL---AGNLCTCPYGFVGPRCETMVCNRHCENGGQC 1404
Query: 369 ---------------TCA----DGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYC 409
TC+ D C NGG C + P+ +C CP G+ G +C+ +C
Sbjct: 1405 LTPDICQCKPGWYGPTCSTALCDPVCLNGGSC-NKPN---TCLCPNGFFGEHCQNA--FC 1458
Query: 410 SSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTC 469
PC NG C+ +C C+ G++GR ++ D C NGG C V +C+C
Sbjct: 1459 -HPPCKNGGHCMRNN---VCVCREGYTGRRFQKSICD---PTCMNGGKC---VGPSTCSC 1508
Query: 470 PPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQ 517
P G++G+ C+ P+ C NG C +C C + G CQ
Sbjct: 1509 PSGWSGKRCNTPICL---QKCKNGGECIAPS---ICHCPSSWEGVRCQ 1550
Score = 109 bits (273), Expect = 8e-24
Identities = 76/266 (28%), Positives = 103/266 (38%), Gaps = 66/266 (24%)
Query: 298 CKNGATCTNT-----GQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSC 352
C NG +C + G G Y C C PG+ G+ CE+ I C +PC G + +SYSC
Sbjct: 1183 CLNGGSCVSDRNFSPGSGVYLCVCLPGFHGSLCEVDISGCQSNPCGLGSYISGF-HSYSC 1241
Query: 353 TCPPGF--------------------------------------YGKICELSAMTCADGP 374
CPP + K +A T P
Sbjct: 1242 DCPPELKVETQFVNQFTTQTVVLTRSDKSVNKEEDDKNAQGRKRHVKPTSGNAFTICKYP 1301
Query: 375 CFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAG 434
C C +P+ C+C GY G NC+ + C N KC+ +C+C G
Sbjct: 1302 CGKSRECV-APN---ICKCKPGYIGSNCQTAL---CDPDCKNHGKCIKPN---ICQCLPG 1351
Query: 435 FSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGA 494
G CD+ + + PC +GGTC G CTCP G+ G C V + C NG
Sbjct: 1352 HGGATCDE---EHCNPPCQHGGTCLAGN---LCTCPYGFVGPRCETMVC---NRHCENGG 1402
Query: 495 TCHERGHRYVCECARGYGGPNCQFLL 520
C +C+C G+ GP C L
Sbjct: 1403 QCLTPD---ICQCKPGWYGPTCSTAL 1425
Score = 86.7 bits (213), Expect = 7e-17
Identities = 66/244 (27%), Positives = 92/244 (37%), Gaps = 64/244 (26%)
Query: 321 TGATCELGIDECDPSPCKNGGSCTDLENS------YSCTCPPGFYGKICELSAMTCADGP 374
T T E+ + CD C NGGSC N Y C C PGF+G +CE+ C P
Sbjct: 1170 TRVTIEVTVKSCD---CLNGGSCVSDRNFSPGSGVYLCVCLPGFHGSLCEVDISGCQSNP 1226
Query: 375 CFNGGRCSDSPDGGYSCRCP-------------------VGYSGFNCEKKIDYCSSS--- 412
C G S YSC CP + S + K+ D ++
Sbjct: 1227 CGLGSYISGF--HSYSCDCPPELKVETQFVNQFTTQTVVLTRSDKSVNKEEDDKNAQGRK 1284
Query: 413 ----------------PCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGG 456
PC +CV +C+C+ G+ G +C + D C N G
Sbjct: 1285 RHVKPTSGNAFTICKYPCGKSRECV---APNICKCKPGYIGSNCQTALCD---PDCKNHG 1338
Query: 457 TCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNC 516
C + C C PG+ G C C + PC +G TC +C C G+ GP C
Sbjct: 1339 KC---IKPNICQCLPGHGGATCDE--EHC-NPPCQHGGTCLAGN---LCTCPYGFVGPRC 1389
Query: 517 QFLL 520
+ ++
Sbjct: 1390 ETMV 1393
Score = 65.5 bits (158), Expect = 2e-10
Identities = 40/123 (32%), Positives = 49/123 (39%), Gaps = 13/123 (10%)
Query: 178 VCDEHYYGEG-----CSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDE 232
VC E Y G C C G TC C GW G C PICL C +
Sbjct: 1475 VCREGYTGRRFQKSICDPTCMNGGKCVGPSTCS------CPSGWSGKRCNTPICLQKC-K 1527
Query: 233 QHGFCDKPGECKCRVGWQGRYCDECIRYPGCLHG-TCQQPWQCNCQEGWGGLFCNQDLNY 291
G C P C C W+G C I P CL+G C P C+C+ + G+ C + +
Sbjct: 1528 NGGECIAPSICHCPSSWEGVRCQIPICNPKCLYGGRCIFPNVCSCRTEYSGVKCEKKIQI 1587
Query: 292 CTH 294
H
Sbjct: 1588 RRH 1590
>gi|181336739 multiple EGF-like-domains 11 [Homo sapiens]
Length = 1044
Score = 159 bits (401), Expect = 1e-38
Identities = 136/459 (29%), Positives = 179/459 (38%), Gaps = 138/459 (30%)
Query: 178 VCDEHYYGEGCSVFCRPRDDAFGHFTCGER-GEKVCNPGWKGPYCTEPICLPGCDEQH-- 234
+C +G+GC + C+ R A +C R GE +C PG+ G YC E +C PG H
Sbjct: 175 LCAPGTHGKGCQLPCQCRHGA----SCDPRAGECLCAPGYTGVYCEE-LCPPGSHGAHCE 229
Query: 235 --------GFCDK-PGECKCRVGWQGRYCDE----------CIRYPGCLHG-TCQQ-PWQ 273
G C GEC C GW G C + C + C HG C Q
Sbjct: 230 LRCPCQNGGTCHHITGECACPPGWTGAVCAQPCPPGTFGQNCSQDCPCHHGGQCDHVTGQ 289
Query: 274 CNCQEGWGGLFCNQDLNY------CTHHKPCKNGATCTNT-------------------- 307
C+C G+ G C ++ + C+ H C NG C+ T
Sbjct: 290 CHCTAGYMGDRCQEECPFGSFGFQCSQHCDCHNGGQCSPTTGACECEPGYKGPRCQERLC 349
Query: 308 -----GQG------------------SYTCSCRPGYTG----ATCELGI--DECD-PSPC 337
G G + C+C+PG++G +C +G D C P C
Sbjct: 350 PEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPGWSGHHCNESCPVGYYGDGCQLPCTC 409
Query: 338 KNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGP-------CFNGGRCSDSPDGGYS 390
+NG C + CTC PGF G++C +S GP C NGG CS DG +
Sbjct: 410 QNGADCHSITGG--CTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNNGGTCSPV-DGSCT 466
Query: 391 CR-----------CPVGYSGFNCEKKIDYCSSSPCSNGAKC--VD---------LGDAYL 428
C+ CP G G NC + S C+NGA C +D LGD
Sbjct: 467 CKEGWQGLDCTLPCPSGTWGLNCNE------SCTCANGAACSPIDGSCSCTPGWLGDTCE 520
Query: 429 CRCQAGFSGRHCDDNVDDCASS----PCANGGTCRDGVNDFSC--TCPPGYTGRNCSAPV 482
C G G +C ++ D C+ + P C G C TCPPG G NCS
Sbjct: 521 LPCPDGTFGLNCSEHCD-CSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSC 579
Query: 483 SRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLP 521
S C NG +C CECA G+ GP CQ + P
Sbjct: 580 S------CENGGSCSPEDGS--CECAPGFRGPLCQRICP 610
Score = 155 bits (391), Expect = 2e-37
Identities = 129/411 (31%), Positives = 160/411 (38%), Gaps = 94/411 (22%)
Query: 178 VCDEHYYGEGCSVFCRPRDDAFGHFTCGE-RGEKVCNPGWKGPYCTE--PI------CLP 228
+C E +G GC++ C DA +C G C PGW G +C E P+ C
Sbjct: 348 LCPEGLHGPGCTLPCPC--DADNTISCHPVTGACTCQPGWSGHHCNESCPVGYYGDGCQL 405
Query: 229 GCDEQHGF-CDK-PGECKCRVGWQGRYC----------DECIRYPGCLHGTCQQP--WQC 274
C Q+G C G C C G+ G C C C +G P C
Sbjct: 406 PCTCQNGADCHSITGGCTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNNGGTCSPVDGSC 465
Query: 275 NCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSY---TCSCRPGYTGATCEL---- 327
C+EGW GL C T C TC N S +CSC PG+ G TCEL
Sbjct: 466 TCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDGSCSCTPGWLGDTCELPCPD 525
Query: 328 ---GIDECDPSPCKNGGSCTDLENSYSC-----------TCPPGFYGKICELSAMTCADG 373
G++ + C + C + C TCPPG +G C +S
Sbjct: 526 GTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCS----- 580
Query: 374 PCFNGGRCSDSPDGGYSCR-----------CPVGYSGFNCEKKIDYC--SSSPCSNGAKC 420
C NGG CS DG C CP G+ G C + C SS PC + +
Sbjct: 581 -CENGGSCSPE-DGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVHSSRPCHHISG- 637
Query: 421 VDLGDAYLCRCQAGFSGRHCDDNV------DDCAS-SPCANGGTCRDGVNDFSCTCPPGY 473
+C C GFSG C+ DCA CAN GTC D SC C PG+
Sbjct: 638 -------ICECLPGFSGALCNQVCAGGYFGQDCAQLCSCANNGTCSP--IDGSCQCFPGW 688
Query: 474 TGRNCSAPV------SRCEHA-PCHNGATCH-ERGHRYVCECARGYGGPNC 516
G++CS C HA CHNGA+C E G C C G+ G C
Sbjct: 689 IGKDCSQACPPGFWGPACFHACSCHNGASCSAEDG---ACHCTPGWTGLFC 736
Score = 149 bits (377), Expect = 7e-36
Identities = 118/386 (30%), Positives = 149/386 (38%), Gaps = 98/386 (25%)
Query: 207 RGEKVCNPGWKGPYCTEPICLPGCDEQ--HGFCDKPGECKCRVGWQGRYCD--------- 255
R C PG+ Y + C+P C E+ HG C P C C GW G C
Sbjct: 83 RRRSQCCPGY---YESGDFCIPLCTEECVHGRCVSPDTCHCEPGWGGPDCSSGCDSDHWG 139
Query: 256 -ECIRYPGCLHGTCQQP--WQCNCQEGWGGLFCNQDLNYCTHHK------PCKNGATC-T 305
C C +G P C C G+ G C + TH K C++GA+C
Sbjct: 140 PHCSNRCQCQNGALCNPITGACVCAAGFRGWRCEELCAPGTHGKGCQLPCQCRHGASCDP 199
Query: 306 NTGQGSYTCSCRPGYTGATCELGIDECDPS----------PCKNGGSCTDLENSYSCTCP 355
G+ C C PGYTG CE + C P PC+NGG+C + C CP
Sbjct: 200 RAGE----CLCAPGYTGVYCE---ELCPPGSHGAHCELRCPCQNGGTCHHITG--ECACP 250
Query: 356 PGFYGKICELSAMTCADG----------PCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKK 405
PG+ G +C A C G PC +GG+C D G C C GY G C+++
Sbjct: 251 PGWTGAVC---AQPCPPGTFGQNCSQDCPCHHGGQC-DHVTG--QCHCTAGYMGDRCQEE 304
Query: 406 IDY------CSS-SPCSNGAKCVDLGDAYLCRCQAGFSGRHCD----------------- 441
+ CS C NG +C A C C+ G+ G C
Sbjct: 305 CPFGSFGFQCSQHCDCHNGGQCSPTTGA--CECEPGYKGPRCQERLCPEGLHGPGCTLPC 362
Query: 442 ----DNVDDCASSPCANGGTCRDGVNDFSC--TCPPGYTGRNCSAPVSRCEHAPCHN--- 492
DN C P TC+ G + C +CP GY G C P + A CH+
Sbjct: 363 PCDADNTISC--HPVTGACTCQPGWSGHHCNESCPVGYYGDGCQLPCTCQNGADCHSITG 420
Query: 493 GATCHERGHRYVC--ECARGYGGPNC 516
G TC VC CA G GPNC
Sbjct: 421 GCTCAPGFMGEVCAVSCAAGTYGPNC 446
Score = 149 bits (377), Expect = 7e-36
Identities = 125/413 (30%), Positives = 164/413 (39%), Gaps = 89/413 (21%)
Query: 179 CDEHYYGEGCSVFCRPRDDAF-----GHFTC-----GERGEKVCNPGWKGPYCTEPICLP 228
CD ++G CS C+ ++ A G C G R E++C PG G C P
Sbjct: 133 CDSDHWGPHCSNRCQCQNGALCNPITGACVCAAGFRGWRCEELCAPGTHGKGCQLP---- 188
Query: 229 GCDEQHG-FCD-KPGECKCRVGWQGRYCDEC-----------IRYPGCLHGTCQQ-PWQC 274
C +HG CD + GEC C G+ G YC+E +R P GTC +C
Sbjct: 189 -CQCRHGASCDPRAGECLCAPGYTGVYCEELCPPGSHGAHCELRCPCQNGGTCHHITGEC 247
Query: 275 NCQEGWGGLFCNQDL------NYCTHHKPCKNGATCTN-TGQGSYTCSCRPGYTGATCE- 326
C GW G C Q C+ PC +G C + TGQ C C GY G C+
Sbjct: 248 ACPPGWTGAVCAQPCPPGTFGQNCSQDCPCHHGGQCDHVTGQ----CHCTAGYMGDRCQE 303
Query: 327 ------LGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADG------- 373
G C NGG C+ + +C C PG+ G C+ C +G
Sbjct: 304 ECPFGSFGFQCSQHCDCHNGGQCS--PTTGACECEPGYKGPRCQ--ERLCPEGLHGPGCT 359
Query: 374 ---PCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKI------DYCS-SSPCSNGAKCVDL 423
PC S P G +C C G+SG +C + D C C NGA C +
Sbjct: 360 LPCPCDADNTISCHPVTG-ACTCQPGWSGHHCNESCPVGYYGDGCQLPCTCQNGADCHSI 418
Query: 424 GDAYLCRCQAGFSGRHCDDNV------DDCAS-SPCANGGTCRDGVNDFSCTCPPGYTGR 476
C C GF G C + +C+S C NGGTC D SCTC G+ G
Sbjct: 419 TGG--CTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNNGGTC--SPVDGSCTCKEGWQGL 474
Query: 477 NCSAP-------VSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPE 522
+C+ P ++ E C NGA C C C G+ G C+ P+
Sbjct: 475 DCTLPCPSGTWGLNCNESCTCANGAACSPIDGS--CSCTPGWLGDTCELPCPD 525
Score = 142 bits (359), Expect = 8e-34
Identities = 121/415 (29%), Positives = 157/415 (37%), Gaps = 103/415 (24%)
Query: 179 CDEHYYGEGCSVFCRPRDDA-FGHFTCGERGEKVCNPGWKGPYCTEPI--------CLPG 229
C +G+ CS C H T G+ C G+ G C E C
Sbjct: 262 CPPGTFGQNCSQDCPCHHGGQCDHVT----GQCHCTAGYMGDRCQEECPFGSFGFQCSQH 317
Query: 230 CDEQHGFCDKP--GECKCRVGWQG-----RYCDECIRYPGC-LHGTCQQP---------W 272
CD +G P G C+C G++G R C E + PGC L C
Sbjct: 318 CDCHNGGQCSPTTGACECEPGYKGPRCQERLCPEGLHGPGCTLPCPCDADNTISCHPVTG 377
Query: 273 QCNCQEGWGGLFCNQDL------NYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCE 326
C CQ GW G CN+ + C C+NGA C + G C+C PG+ G C
Sbjct: 378 ACTCQPGWSGHHCNESCPVGYYGDGCQLPCTCQNGADCHSITGG---CTCAPGFMGEVCA 434
Query: 327 LGIDECDPSP-------CKNGGSCTDLENSYSCTCPPGFYGKICELS------AMTCADG 373
+ P C NGG+C+ ++ SCTC G+ G C L + C +
Sbjct: 435 VSCAAGTYGPNCSSICSCNNGGTCSPVDG--SCTCKEGWQGLDCTLPCPSGTWGLNCNES 492
Query: 374 -PCFNGGRCSDSPDGGYSCR-----------CPVGYSGFNCEKKIDYCSSSPCSNGAKCV 421
C NG CS DG SC CP G G NC + D CS+ C
Sbjct: 493 CTCANGAACSPI-DGSCSCTPGWLGDTCELPCPDGTFGLNCSEHCD------CSHADGCD 545
Query: 422 DLGDAYLCRCQAGFSGRHCDDNV------DDCA-SSPCANGGTCRDGVNDFSCT------ 468
+ C C AG++G CD +C+ S C NGG+C C
Sbjct: 546 PVTGH--CCCLAGWTGIRCDSTCPPGRWGPNCSVSCSCENGGSCSPEDGSCECAPGFRGP 603
Query: 469 -----CPPGYTGRNCSAPVSRCEHA--PCHNGATCHERGHRYVCECARGYGGPNC 516
CPPG+ G C+ P C H+ PCH H G +CEC G+ G C
Sbjct: 604 LCQRICPPGFYGHGCAQPCPLCVHSSRPCH-----HISG---ICECLPGFSGALC 650
Score = 121 bits (304), Expect = 2e-27
Identities = 121/482 (25%), Positives = 162/482 (33%), Gaps = 155/482 (32%)
Query: 179 CDEHYYGEGCSVFCRPRDDAFGHFTCGE-RGEKVCNPGWKGPYCTEPI--------CLPG 229
C YG CS C + TC G C GW+G CT P C
Sbjct: 437 CAAGTYGPNCSSICSCNNGG----TCSPVDGSCTCKEGWQGLDCTLPCPSGTWGLNCNES 492
Query: 230 CDEQHGFCDKP--GECKCRVGWQGRYCD----------ECIRYPGCLHGTCQQP--WQCN 275
C +G P G C C GW G C+ C + C H P C
Sbjct: 493 CTCANGAACSPIDGSCSCTPGWLGDTCELPCPDGTFGLNCSEHCDCSHADGCDPVTGHCC 552
Query: 276 CQEGWGGLFCNQDLN------YCTHHKPCKNGATCTNT---------------------- 307
C GW G+ C+ C+ C+NG +C+
Sbjct: 553 CLAGWTGIRCDSTCPPGRWGPNCSVSCSCENGGSCSPEDGSCECAPGFRGPLCQRICPPG 612
Query: 308 --GQG------------------SYTCSCRPGYTGATCE-------LGIDECDPSPCKNG 340
G G S C C PG++GA C G D C N
Sbjct: 613 FYGHGCAQPCPLCVHSSRPCHHISGICECLPGFSGALCNQVCAGGYFGQDCAQLCSCANN 672
Query: 341 GSCTDLENSYSC-----------TCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGY 389
G+C+ ++ S C CPPGF+G C C+ C NG CS + DG
Sbjct: 673 GTCSPIDGSCQCFPGWIGKDCSQACPPGFWGPAC---FHACS---CHNGASCS-AEDG-- 723
Query: 390 SCRCPVGYSGFNCEKKI-------DYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDD 442
+C C G++G C ++ D C NGA C + C C+ GF+G+HC+
Sbjct: 724 ACHCTPGWTGLFCTQRCPAAFFGKDCGRVCQCQNGASCDHISGK--CTCRTGFTGQHCEQ 781
Query: 443 NVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATC-HERGH 501
C PG G C CE C N +TC H G
Sbjct: 782 R-------------------------CAPGTFGYGCQ---QLCE---CMNNSTCDHVTG- 809
Query: 502 RYVCECARGYGGPNCQ---FLLPELPPGPAVVDLTEKLEGQGGPFPWVAVCAGVILVLML 558
C C+ G+ G C ++ EL P T+ G V G++L+L L
Sbjct: 810 --TCYCSPGFKGIRCDQAALMMEELNP------YTKISPALGAERHSVGAVTGIMLLLFL 861
Query: 559 LL 560
++
Sbjct: 862 IV 863
Score = 87.0 bits (214), Expect = 5e-17
Identities = 68/232 (29%), Positives = 92/232 (39%), Gaps = 53/232 (22%)
Query: 178 VCDEHYYGEGCSVFC-------RPRDDAFGHFTC-----GERGEKVCNPGWKGPYCTEPI 225
+C +YG GC+ C RP G C G +VC G+ G C +
Sbjct: 608 ICPPGFYGHGCAQPCPLCVHSSRPCHHISGICECLPGFSGALCNQVCAGGYFGQDCAQ-- 665
Query: 226 CLPGCDEQHGFCDK-PGECKCRVGWQGRYCDECIRY----PGCLHG-------TCQ-QPW 272
L C +G C G C+C GW G+ C + P C H +C +
Sbjct: 666 -LCSC-ANNGTCSPIDGSCQCFPGWIGKDCSQACPPGFWGPACFHACSCHNGASCSAEDG 723
Query: 273 QCNCQEGWGGLFCNQDL------NYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCE 326
C+C GW GLFC Q C C+NGA+C + S C+CR G+TG CE
Sbjct: 724 ACHCTPGWTGLFCTQRCPAAFFGKDCGRVCQCQNGASCDHI---SGKCTCRTGFTGQHCE 780
Query: 327 LGIDECDPS----------PCKNGGSCTDLENSYSCTCPPGFYGKICELSAM 368
C P C N +C + +C C PGF G C+ +A+
Sbjct: 781 ---QRCAPGTFGYGCQQLCECMNNSTCDHVTG--TCYCSPGFKGIRCDQAAL 827
Score = 68.6 bits (166), Expect = 2e-11
Identities = 61/212 (28%), Positives = 77/212 (36%), Gaps = 78/212 (36%)
Query: 343 CTDLENSYSCT-----------------------CPPGFY--GKIC-ELSAMTCADGPCF 376
CTD+ N + CT C PG+Y G C L C G C
Sbjct: 54 CTDILNWFKCTRHRISYKTAYRRGLRTMYRRRSQCCPGYYESGDFCIPLCTEECVHGRCV 113
Query: 377 NGGRCSDSPDGGYSCRCPVGYSGFNCEKKID------YCSSS-PCSNGAKCVDLGDAYLC 429
SPD +C C G+ G +C D +CS+ C NGA C + A C
Sbjct: 114 -------SPD---TCHCEPGWGGPDCSSGCDSDHWGPHCSNRCQCQNGALCNPITGA--C 161
Query: 430 RCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAP 489
C AGF G C++ C PG G+ C P C+
Sbjct: 162 VCAAGFRGWRCEE-------------------------LCAPGTHGKGCQLP---CQ--- 190
Query: 490 CHNGATCHERGHRYVCECARGYGGPNCQFLLP 521
C +GA+C R C CA GY G C+ L P
Sbjct: 191 CRHGASCDPRAGE--CLCAPGYTGVYCEELCP 220
>gi|126091152 cubilin [Homo sapiens]
Length = 3623
Score = 155 bits (392), Expect = 1e-37
Identities = 103/326 (31%), Positives = 147/326 (45%), Gaps = 59/326 (18%)
Query: 211 VCNPGWKGPYCTEPICLPGCDEQHGF---CDKPGECKCRVGWQGRYC------------- 254
+C P WKGP C+ + C+ G C G C +G +C
Sbjct: 157 ICPPQWKGPLCSADV--NECEIYSGTPLSCQNGGTCVNTMGSYSCHCPPETYGPQCASKY 214
Query: 255 DECI--RYPGCLHGTCQQ---------PWQCNCQEGW----GGLFCNQDLNYCTHHK-PC 298
D+C C+HG C+ + C C GW C D + C+ PC
Sbjct: 215 DDCEGGSVARCVHGICEDLMREQAGEPKYSCVCDAGWMFSPNSPACTLDRDECSFQPGPC 274
Query: 299 KNGATCTNTGQGSYTC-SCRPGY--TGATCELGIDECDPSPCKNGG-------SCTDLEN 348
C NT QGS+ C +C G+ G CE I+EC+ NGG C +
Sbjct: 275 STLVQCFNT-QGSFYCGACPTGWQGNGYICE-DINECE---INNGGCSVAPPVECVNTPG 329
Query: 349 SYSC-TCPPGFYG--KICELSAM-TCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFN--- 401
S C CPPG+ G ++C L+ + + ++G C CS + C C GY+G
Sbjct: 330 SSHCQACPPGYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGP 389
Query: 402 --CEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCR 459
C + + C S PC NG +C+D Y C+C +G++G +C +N+++C S+PC NGGTC
Sbjct: 390 NGCVQLSNICLSHPCLNG-QCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCV 448
Query: 460 DGVNDFSCTCPPGYTGRNCSAPVSRC 485
DGV+ FSC C +TG C P C
Sbjct: 449 DGVDSFSCECTRLWTGALCQVPQQVC 474
Score = 132 bits (331), Expect = 1e-30
Identities = 104/362 (28%), Positives = 136/362 (37%), Gaps = 85/362 (23%)
Query: 266 GTC---QQPWQCNCQEGWGGLFCNQDLNYCTHHK----PCKNGATCTNTGQGSYTCSCRP 318
GTC + C C W G C+ D+N C + C+NG TC NT GSY+C C P
Sbjct: 145 GTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNT-MGSYSCHCPP 203
Query: 319 GYTGATCELGIDECDPSPCKN--GGSCTDL------ENSYSCTCPPGFY----GKICELS 366
G C D+C+ G C DL E YSC C G+ C L
Sbjct: 204 ETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVCDAGWMFSPNSPACTLD 263
Query: 367 AMTCA--DGPCFNGGRCSDSPDGGYSCRCPVGYSGFN--------CEKKIDYCSSSP--- 413
C+ GPC +C ++ Y CP G+ G CE CS +P
Sbjct: 264 RDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICEDINECEINNGGCSVAPPVE 323
Query: 414 ------------------------------------CSNGAKCVD-LGDAYLCRCQAGFS 436
C A C LG LC C G++
Sbjct: 324 CVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYT 383
Query: 437 GRH-----CDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCH 491
G C + C S PC NG C D V+ + C C G+TG NC+ ++ C PC
Sbjct: 384 GNGYGPNGCVQLSNICLSHPCLNG-QCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCL 442
Query: 492 NGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVDLTEKLEGQGGPFPWVAVCAG 551
NG TC + + CEC R + G CQ +P+ G E L G G F + + G
Sbjct: 443 NGGTCVDGVDSFSCECTRLWTGALCQ--VPQQVCG-------ESLSGINGSFSYRSPDVG 493
Query: 552 VI 553
+
Sbjct: 494 YV 495
Score = 112 bits (279), Expect = 2e-24
Identities = 82/265 (30%), Positives = 112/265 (42%), Gaps = 39/265 (14%)
Query: 282 GLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECD-----PSP 336
GL D C+ + PC+NG TC N S+ C C P + G C ++EC+ P
Sbjct: 126 GLQQTVDKKVCSSN-PCQNGGTCLNL-HDSFFCICPPQWKGPLCSADVNECEIYSGTPLS 183
Query: 337 CKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGP---CFNGGRCSD-----SPDGG 388
C+NGG+C + SYSC CPP YG C C G C + G C D + +
Sbjct: 184 CQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVH-GICEDLMREQAGEPK 242
Query: 389 YSCRCPVGY----SGFNCEKKIDYCS--SSPCSNGAKCVDLGDAYLC-RCQAGFSG---- 437
YSC C G+ + C D CS PCS +C + ++ C C G+ G
Sbjct: 243 YSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYI 302
Query: 438 ----RHCDDNVDDCASSPCANGGTCRDGVNDFSC-TCPPGY--TGRNCS-APVSRCEHAP 489
C+ N C+ +P C + C CPPGY GR C+ + +
Sbjct: 303 CEDINECEINNGGCSVAPPVE---CVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGG 359
Query: 490 CHNGATCHER-GHRYVCECARGYGG 513
CH A+C G +C C GY G
Sbjct: 360 CHPDASCSSTLGSLPLCTCLPGYTG 384
Score = 91.3 bits (225), Expect = 3e-18
Identities = 75/220 (34%), Positives = 93/220 (42%), Gaps = 40/220 (18%)
Query: 200 GHFTCGERGEKVCNPGWKGP-YCTEPICLPGCDEQHGFCD--KPGEC----------KCR 246
G F CG C GW+G Y E I C+ +G C P EC C
Sbjct: 285 GSFYCG-----ACPTGWQGNGYICEDI--NECEINNGGCSVAPPVECVNTPGSSHCQACP 337
Query: 247 VGWQG--RYC---DECIRYPGCLH--GTCQQPWQ----CNCQ-----EGWGGLFCNQDLN 290
G+QG R C D C G H +C C C G+G C Q N
Sbjct: 338 PGYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSN 397
Query: 291 YCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSY 350
C H PC NG C +T G Y C C G+TG C I+EC +PC NGG+C D +S+
Sbjct: 398 ICLSH-PCLNGQ-CIDTVSG-YFCKCDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSF 454
Query: 351 SCTCPPGFYGKICELSAMTCADG-PCFNGGRCSDSPDGGY 389
SC C + G +C++ C + NG SPD GY
Sbjct: 455 SCECTRLWTGALCQVPQQVCGESLSGINGSFSYRSPDVGY 494
Score = 70.9 bits (172), Expect = 4e-12
Identities = 50/176 (28%), Positives = 67/176 (38%), Gaps = 21/176 (11%)
Query: 358 FYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYC---SSSP- 413
F G + C+ PC NGG C + D + C CP + G C ++ C S +P
Sbjct: 124 FQGLQQTVDKKVCSSNPCQNGGTCLNLHD-SFFCICPPQWKGPLCSADVNECEIYSGTPL 182
Query: 414 -CSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCAN--GGTCRD------GVND 464
C NG CV+ +Y C C G C DDC A G C D G
Sbjct: 183 SCQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPK 242
Query: 465 FSCTCPPGY----TGRNCSAPVSRC--EHAPCHNGATC-HERGHRYVCECARGYGG 513
+SC C G+ C+ C + PC C + +G Y C G+ G
Sbjct: 243 YSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQG 298
Score = 68.2 bits (165), Expect = 3e-11
Identities = 32/75 (42%), Positives = 38/75 (50%), Gaps = 5/75 (6%)
Query: 447 CASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCE-----HAPCHNGATCHERGH 501
C+S+PC NGGTC + + F C CPP + G CSA V+ CE C NG TC
Sbjct: 136 CSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNTMG 195
Query: 502 RYVCECARGYGGPNC 516
Y C C GP C
Sbjct: 196 SYSCHCPPETYGPQC 210
>gi|224451131 eyes shut homolog isoform 2 [Homo sapiens]
Length = 619
Score = 155 bits (391), Expect = 2e-37
Identities = 87/280 (31%), Positives = 123/280 (43%), Gaps = 15/280 (5%)
Query: 252 RYCDECIRYPGCL-HGTC-----QQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCT 305
++C E + C HG C + + C+CQ + G +C Q+L+ C+ KPCKN +C
Sbjct: 172 QFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYC-QELDACSF-KPCKNNGSCI 229
Query: 306 NTGQG----SYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGK 361
N + +Y C C P +TG C I +C P C +G NS+ C C F G
Sbjct: 230 NKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGP 289
Query: 362 ICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCV 421
CE+SA C + G C +S Y+ CP G S N E + S PC NG C+
Sbjct: 290 FCEVSAKPCVSLLFWKRGICPNS-SSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCI 348
Query: 422 DLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAP 481
+ + +C C F+ C C S P N TC+ D+ C+C G+T +NC
Sbjct: 349 KISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKA 408
Query: 482 VSRCE--HAPCHNGATCHERGHRYVCECARGYGGPNCQFL 519
+ C+ C N C R+ C G C FL
Sbjct: 409 IDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFL 448
Score = 60.1 bits (144), Expect = 7e-09
Identities = 75/331 (22%), Positives = 111/331 (33%), Gaps = 72/331 (21%)
Query: 179 CDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCD 238
CDE + G C V +P +RG +C P Y E C G Q+G D
Sbjct: 282 CDEQFSGPFCEVSAKP----CVSLLFWKRG--IC-PNSSSAYTYE--CPKGSSSQNGETD 332
Query: 239 --KPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHK 296
+ C+ G +CI+ + C C + L C C
Sbjct: 333 VSEFSLVPCQNG------TDCIKISNDV--------MCICSPIFTDLLCKSIQTSCESF- 377
Query: 297 PCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECD--PSPCKNGGSCTDLENSYSCTC 354
P +N ATC + Y CSC G+T CE ID C C N C ++ + C
Sbjct: 378 PLRNNATCKKC-EKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVC 436
Query: 355 PPG-------FYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSG-------- 399
PG F + + C G F+ G C D + +G++G
Sbjct: 437 IPGCTKNPCWFLKNVYLIHQHLCYCGVTFH-GICQDKGPAQFEYVWQLGFAGSEGEKCQG 495
Query: 400 ---------FNCEKKIDYCSSSP----------------CSNGAKCVDLGDA--YLCRCQ 432
NC + Y + C+NG C+ D+ Y C
Sbjct: 496 VIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEEDSQEYRYLCF 555
Query: 433 AGFSGRHCDDNVDDCASSPCANGGTCRDGVN 463
++G +N D + C + C+D +N
Sbjct: 556 LRWAGNMYLENTTDDQENECQHEAVCKDEIN 586
Score = 43.1 bits (100), Expect = 9e-04
Identities = 22/88 (25%), Positives = 36/88 (40%), Gaps = 8/88 (9%)
Query: 445 DDCASSPCANGGTCRDGV--NDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHR 502
+ +S C+ G C +SC C P ++G+ C + C PC N +C +
Sbjct: 176 ESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQE-LDACSFKPCKNNGSCINKREN 234
Query: 503 -----YVCECARGYGGPNCQFLLPELPP 525
Y C C + G NC ++ + P
Sbjct: 235 WDEQAYECVCHPPFTGKNCSEIIGQCQP 262
>gi|38093661 eyes shut homolog isoform 3 [Homo sapiens]
Length = 594
Score = 155 bits (391), Expect = 2e-37
Identities = 87/280 (31%), Positives = 123/280 (43%), Gaps = 15/280 (5%)
Query: 252 RYCDECIRYPGCL-HGTC-----QQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCT 305
++C E + C HG C + + C+CQ + G +C Q+L+ C+ KPCKN +C
Sbjct: 172 QFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYC-QELDACSF-KPCKNNGSCI 229
Query: 306 NTGQG----SYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGK 361
N + +Y C C P +TG C I +C P C +G NS+ C C F G
Sbjct: 230 NKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGP 289
Query: 362 ICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCV 421
CE+SA C + G C +S Y+ CP G S N E + S PC NG C+
Sbjct: 290 FCEVSAKPCVSLLFWKRGICPNS-SSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCI 348
Query: 422 DLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAP 481
+ + +C C F+ C C S P N TC+ D+ C+C G+T +NC
Sbjct: 349 KISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKA 408
Query: 482 VSRCE--HAPCHNGATCHERGHRYVCECARGYGGPNCQFL 519
+ C+ C N C R+ C G C FL
Sbjct: 409 IDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFL 448
Score = 60.1 bits (144), Expect = 7e-09
Identities = 75/331 (22%), Positives = 111/331 (33%), Gaps = 72/331 (21%)
Query: 179 CDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCD 238
CDE + G C V +P +RG +C P Y E C G Q+G D
Sbjct: 282 CDEQFSGPFCEVSAKP----CVSLLFWKRG--IC-PNSSSAYTYE--CPKGSSSQNGETD 332
Query: 239 --KPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHK 296
+ C+ G +CI+ + C C + L C C
Sbjct: 333 VSEFSLVPCQNG------TDCIKISNDV--------MCICSPIFTDLLCKSIQTSCESF- 377
Query: 297 PCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECD--PSPCKNGGSCTDLENSYSCTC 354
P +N ATC + Y CSC G+T CE ID C C N C ++ + C
Sbjct: 378 PLRNNATCKKC-EKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVC 436
Query: 355 PPG-------FYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSG-------- 399
PG F + + C G F+ G C D + +G++G
Sbjct: 437 IPGCTKNPCWFLKNVYLIHQHLCYCGVTFH-GICQDKGPAQFEYVWQLGFAGSEGEKCQG 495
Query: 400 ---------FNCEKKIDYCSSSP----------------CSNGAKCVDLGDA--YLCRCQ 432
NC + Y + C+NG C+ D+ Y C
Sbjct: 496 VIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEEDSQEYRYLCF 555
Query: 433 AGFSGRHCDDNVDDCASSPCANGGTCRDGVN 463
++G +N D + C + C+D +N
Sbjct: 556 LRWAGNMYLENTTDDQENECQHEAVCKDEIN 586
Score = 43.1 bits (100), Expect = 9e-04
Identities = 22/88 (25%), Positives = 36/88 (40%), Gaps = 8/88 (9%)
Query: 445 DDCASSPCANGGTCRDGV--NDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHR 502
+ +S C+ G C +SC C P ++G+ C + C PC N +C +
Sbjct: 176 ESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQE-LDACSFKPCKNNGSCINKREN 234
Query: 503 -----YVCECARGYGGPNCQFLLPELPP 525
Y C C + G NC ++ + P
Sbjct: 235 WDEQAYECVCHPPFTGKNCSEIIGQCQP 262
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 154 bits (388), Expect = 4e-37
Identities = 67/170 (39%), Positives = 88/170 (51%), Gaps = 22/170 (12%)
Query: 295 HKPCKNGATC---------------------TNTGQGSYTCSCRPGYTGATCELGIDECD 333
H PC+NG +C N + C C PGY G+ CE+ IDEC
Sbjct: 3808 HGPCQNGGSCLRRLAVSSVLKSRESLPVIIVANEPLQPFLCKCLPGYAGSWCEIDIDECL 3867
Query: 334 PSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRC 393
PSPC +GG+C +L +SC+CP GF G+ CE C PC NG C + P G ++C C
Sbjct: 3868 PSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDINECLQSPCKNGAICQNFP-GSFNCVC 3926
Query: 394 PVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDN 443
GY+G CE ++YC +PC NG C D+Y C C G G+HC+ N
Sbjct: 3927 KTGYTGKMCESSVNYCECNPCFNGGSCQSGVDSYYCHCPFGVFGKHCELN 3976
Score = 140 bits (354), Expect = 3e-33
Identities = 62/171 (36%), Positives = 91/171 (53%), Gaps = 23/171 (13%)
Query: 330 DECDPSPCKNGGSC----------------------TDLENSYSCTCPPGFYGKICELSA 367
D C PC+NGGSC + + C C PG+ G CE+
Sbjct: 3804 DSCVHGPCQNGGSCLRRLAVSSVLKSRESLPVIIVANEPLQPFLCKCLPGYAGSWCEIDI 3863
Query: 368 MTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAY 427
C PC +GG C + GG+SC CP G++G CE+ I+ C SPC NGA C + ++
Sbjct: 3864 DECLPSPCHSGGTCHNLV-GGFSCSCPDGFTGRACERDINECLQSPCKNGAICQNFPGSF 3922
Query: 428 LCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNC 478
C C+ G++G+ C+ +V+ C +PC NGG+C+ GV+ + C CP G G++C
Sbjct: 3923 NCVCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVDSYYCHCPFGVFGKHC 3973
Score = 136 bits (343), Expect = 6e-32
Identities = 61/170 (35%), Positives = 85/170 (50%), Gaps = 21/170 (12%)
Query: 369 TCADGPCFNGGRC---------------------SDSPDGGYSCRCPVGYSGFNCEKKID 407
+C GPC NGG C ++ P + C+C GY+G CE ID
Sbjct: 3805 SCVHGPCQNGGSCLRRLAVSSVLKSRESLPVIIVANEPLQPFLCKCLPGYAGSWCEIDID 3864
Query: 408 YCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSC 467
C SPC +G C +L + C C GF+GR C+ ++++C SPC NG C++ F+C
Sbjct: 3865 ECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDINECLQSPCKNGAICQNFPGSFNC 3924
Query: 468 TCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQ 517
C GYTG+ C + V+ CE PC NG +C Y C C G G +C+
Sbjct: 3925 VCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVDSYYCHCPFGVFGKHCE 3974
Score = 134 bits (338), Expect = 2e-31
Identities = 66/179 (36%), Positives = 85/179 (47%), Gaps = 34/179 (18%)
Query: 256 ECIRYPGCLHGTCQ-------------------------------QPWQCNCQEGWGGLF 284
E + + C+HG CQ QP+ C C G+ G +
Sbjct: 3799 ESVDHDSCVHGPCQNGGSCLRRLAVSSVLKSRESLPVIIVANEPLQPFLCKCLPGYAGSW 3858
Query: 285 CNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCT 344
C D++ C PC +G TC N G ++CSC G+TG CE I+EC SPCKNG C
Sbjct: 3859 CEIDIDECLP-SPCHSGGTCHNL-VGGFSCSCPDGFTGRACERDINECLQSPCKNGAICQ 3916
Query: 345 DLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCE 403
+ S++C C G+ GK+CE S C PCFNGG C D Y C CP G G +CE
Sbjct: 3917 NFPGSFNCVCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVD-SYYCHCPFGVFGKHCE 3974
Score = 122 bits (306), Expect = 1e-27
Identities = 59/136 (43%), Positives = 79/136 (58%), Gaps = 9/136 (6%)
Query: 239 KPGECKCRVGWQGRYC----DECIRYPGCLHGTCQQ---PWQCNCQEGWGGLFCNQDLNY 291
+P CKC G+ G +C DEC+ P GTC + C+C +G+ G C +D+N
Sbjct: 3844 QPFLCKCLPGYAGSWCEIDIDECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDINE 3903
Query: 292 CTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYS 351
C PCKNGA C N GS+ C C+ GYTG CE ++ C+ +PC NGGSC +SY
Sbjct: 3904 CLQ-SPCKNGAICQNF-PGSFNCVCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVDSYY 3961
Query: 352 CTCPPGFYGKICELSA 367
C CP G +GK CEL++
Sbjct: 3962 CHCPFGVFGKHCELNS 3977
Score = 62.8 bits (151), Expect = 1e-09
Identities = 37/106 (34%), Positives = 50/106 (47%), Gaps = 19/106 (17%)
Query: 409 CSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVND-FSC 467
C+S+PC C++ AY C DCAS PC NGG+C G++ F+C
Sbjct: 4404 CASNPCWGDLLCINQWYAYRCVPPG------------DCASHPCQNGGSCEPGLHSGFTC 4451
Query: 468 TCPPGYTGRNCSAPVSRCEHAPCHNGATC---HERGHRYVCECARG 510
+CP +TGR C V+ C C G C GH VC ++G
Sbjct: 4452 SCPDSHTGRTCEMVVA-CLGVLCPQGKVCKAGSPAGH--VCVLSQG 4494
Score = 51.2 bits (121), Expect = 3e-06
Identities = 29/93 (31%), Positives = 38/93 (40%), Gaps = 13/93 (13%)
Query: 328 GIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDG 387
G + C +PC C + +Y C PPG CA PC NGG C
Sbjct: 4400 GPNICASNPCWGDLLCINQWYAYRCV-PPG-----------DCASHPCQNGGSCEPGLHS 4447
Query: 388 GYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKC 420
G++C CP ++G CE + C C G C
Sbjct: 4448 GFTCSCPDSHTGRTCEMVV-ACLGVLCPQGKVC 4479
Score = 50.4 bits (119), Expect = 6e-06
Identities = 75/334 (22%), Positives = 110/334 (32%), Gaps = 63/334 (18%)
Query: 200 GHFTCGERGEKVCNPGWKGPYCTEPI--CLPGCDEQHGFCDK-PGE--CKCRVGWQGRYC 254
G F+C C G+ G C I CL + C PG C C+ G+ G+ C
Sbjct: 3882 GGFSCS------CPDGFTGRACERDINECLQSPCKNGAICQNFPGSFNCVCKTGYTGKMC 3935
Query: 255 DECIRYPGCLH----GTCQQ---PWQCNCQEGWGGLFCN------QDLNYCTHHKPCKNG 301
+ + Y C G+CQ + C+C G G C ++L+Y N
Sbjct: 3936 ESSVNYCECNPCFNGGSCQSGVDSYYCHCPFGVFGKHCELNSYGFEELSYMEFPSLDPNN 3995
Query: 302 -------ATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTC 354
AT + Y + G L I E N GS T +
Sbjct: 3996 NYIYVKFATIKSHALLLYNYDNQTGDRAEFLALEIAEERLRFSYNLGSGTYKLTTMKKVS 4055
Query: 355 PPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPC 414
F+ I + M + CS++ + GY C V + + +D +
Sbjct: 4056 DGHFHTVIARRAGMAAS----LTVDSCSENQEPGY---CTVSNVAVSDDWTLDVQPNRVT 4108
Query: 415 SNGAKC----------VDLGDAYLCRCQAGFSGR---------------HCDDNVDDCAS 449
G + V+ D C + +GR C C
Sbjct: 4109 VGGIRSLEPILQRRGHVESHDFVGCIMEFAVNGRPLEPSQALAAQGILDQCPRLEGACTR 4168
Query: 450 SPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVS 483
SPC +GGTC D + C C G TG+ C V+
Sbjct: 4169 SPCQHGGTCMDYWSWQQCHCKEGLTGKYCEKSVT 4202
Score = 50.1 bits (118), Expect = 7e-06
Identities = 30/84 (35%), Positives = 37/84 (44%), Gaps = 10/84 (11%)
Query: 268 CQQPWQCNCQEGWGGLFC-NQDLNY-------CTHHKPCKNGATCTNTGQGSYTCSCRPG 319
C+ P C WG L C NQ Y C H PC+NG +C +TCSC
Sbjct: 4398 CRGPNICASNPCWGDLLCINQWYAYRCVPPGDCASH-PCQNGGSCEPGLHSGFTCSCPDS 4456
Query: 320 YTGATCELGIDECDPSPCKNGGSC 343
+TG TCE+ + C C G C
Sbjct: 4457 HTGRTCEM-VVACLGVLCPQGKVC 4479
Score = 42.0 bits (97), Expect = 0.002
Identities = 29/94 (30%), Positives = 37/94 (39%), Gaps = 17/94 (18%)
Query: 370 CADGPCFNGGRCSDSPDGGYSCRC-PVGYSGFNCEKKIDYCSSSPCSNGAKCVD-LGDAY 427
CA PC+ C + Y+ RC P G C+S PC NG C L +
Sbjct: 4404 CASNPCWGDLLCINQ---WYAYRCVPPGD-----------CASHPCQNGGSCEPGLHSGF 4449
Query: 428 LCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDG 461
C C +GR C + V C C G C+ G
Sbjct: 4450 TCSCPDSHTGRTC-EMVVACLGVLCPQGKVCKAG 4482
Score = 33.5 bits (75), Expect = 0.71
Identities = 17/65 (26%), Positives = 24/65 (36%), Gaps = 22/65 (33%)
Query: 485 CEHAPCHNGATC----------------------HERGHRYVCECARGYGGPNCQFLLPE 522
C H PC NG +C +E ++C+C GY G C+ + E
Sbjct: 3806 CVHGPCQNGGSCLRRLAVSSVLKSRESLPVIIVANEPLQPFLCKCLPGYAGSWCEIDIDE 3865
Query: 523 LPPGP 527
P P
Sbjct: 3866 CLPSP 3870
Score = 32.0 bits (71), Expect = 2.1
Identities = 18/63 (28%), Positives = 25/63 (39%), Gaps = 8/63 (12%)
Query: 478 CSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVDLTEKLE 537
C C +PC +G TC + C C G G C+ + P A+ LE
Sbjct: 4159 CPRLEGACTRSPCQHGGTCMDYWSWQQCHCKEGLTGKYCE---KSVTPDTAL-----SLE 4210
Query: 538 GQG 540
G+G
Sbjct: 4211 GKG 4213
>gi|46397353 Notch homolog 2 N-terminal like protein [Homo sapiens]
Length = 236
Score = 152 bits (385), Expect = 8e-37
Identities = 81/204 (39%), Positives = 110/204 (53%), Gaps = 10/204 (4%)
Query: 274 CNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQ-GSYTCSCRPGYTGATCELGIDE- 331
C C EG+ G +C Q + C ++ C+NG TC G TC C G+TG C+
Sbjct: 12 CKCPEGFLGEYC-QHRDPCEKNR-CQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHP 69
Query: 332 CDPS-PCKNGGSCTDLE-NSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGY 389
C S PC NGG+C L ++Y CTC GF GK C+ + C PC NG C+ + +
Sbjct: 70 CFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTD-ACLSHPCANGSTCTTVANQ-F 127
Query: 390 SCRCPVGYSGFNCEKKIDYCS-SSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCA 448
SC+C G++G CE ++ C C +G C++L +Y C+C GF+G++CD CA
Sbjct: 128 SCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCA 187
Query: 449 SSPCANGGTCRD-GVNDFSCTCPP 471
SPC NGGTCR G F C C P
Sbjct: 188 PSPCVNGGTCRQTGDFTFECNCLP 211
Score = 149 bits (375), Expect = 1e-35
Identities = 71/210 (33%), Positives = 106/210 (50%), Gaps = 8/210 (3%)
Query: 304 CTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTD--LENSYSCTCPPGFYGK 361
C G+ C C G+ G C+ D C+ + C+NGG+C + +C C GF G+
Sbjct: 2 CVTYHNGTGYCKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGE 60
Query: 362 ICELSAM--TCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAK 419
C+ S PC NGG C Y C C VG++G C+ D C S PC+NG+
Sbjct: 61 DCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGST 119
Query: 420 CVDLGDAYLCRCQAGFSGRHCDDNVDDC-ASSPCANGGTCRDGVNDFSCTCPPGYTGRNC 478
C + + + C+C GF+G+ C+ +V++C C +GGTC + + C C G+TG+ C
Sbjct: 120 CTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYC 179
Query: 479 SAPVSRCEHAPCHNGATCHERG-HRYVCEC 507
+ C +PC NG TC + G + C C
Sbjct: 180 DSLYVPCAPSPCVNGGTCRQTGDFTFECNC 209
Score = 138 bits (348), Expect = 2e-32
Identities = 74/202 (36%), Positives = 98/202 (48%), Gaps = 13/202 (6%)
Query: 241 GECKCRVGWQGRYC---DECIRYPGCLHGTCQQPWQ-----CNCQEGWGGLFCNQDLNY- 291
G CKC G+ G YC D C + GTC C C G+ G C ++
Sbjct: 10 GYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHP 69
Query: 292 CTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYS 351
C +PC NG TC + +Y C+C+ G+TG C+ D C PC NG +CT + N +S
Sbjct: 70 CFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQ-WTDACLSHPCANGSTCTTVANQFS 128
Query: 352 CTCPPGFYGKICELSAMTC-ADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCS 410
C C GF G+ CE C G C +GG C + P G Y C+C G++G C+ C+
Sbjct: 129 CKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLP-GSYQCQCLQGFTGQYCDSLYVPCA 187
Query: 411 SSPCSNGAKCVDLGD-AYLCRC 431
SPC NG C GD + C C
Sbjct: 188 PSPCVNGGTCRQTGDFTFECNC 209
Score = 137 bits (345), Expect = 3e-32
Identities = 71/183 (38%), Positives = 91/183 (49%), Gaps = 7/183 (3%)
Query: 352 CTCPPGFYGKICELSAMTCADGPCFNGGRC-SDSPDGGYSCRCPVGYSGFNCEKKIDYCS 410
C CP GF G+ C+ C C NGG C + + G +CRC G++G +C+ +
Sbjct: 12 CKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPC 70
Query: 411 --SSPCSNGAKCVDLG-DAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSC 467
S PC NG C L D Y C CQ GF+G+ C D C S PCANG TC N FSC
Sbjct: 71 FVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVANQFSC 129
Query: 468 TCPPGYTGRNCSAPVSRCE-HAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPG 526
C G+TG+ C V+ C+ C +G TC Y C+C +G+ G C L P
Sbjct: 130 KCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPS 189
Query: 527 PAV 529
P V
Sbjct: 190 PCV 192
Score = 127 bits (319), Expect = 4e-29
Identities = 71/199 (35%), Positives = 97/199 (48%), Gaps = 20/199 (10%)
Query: 212 CNPGWKGPYCTE-PICLPGCDEQHGFCDKPG-----ECKCRVGWQGRYCDECIRYP---- 261
C G+ G YC C + G C C+C G+ G C +P
Sbjct: 14 CPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVS 73
Query: 262 -GCLHG-TC----QQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCS 315
CL+G TC + ++C CQ G+ G C Q + C H PC NG+TCT T ++C
Sbjct: 74 RPCLNGGTCHMLSRDTYECTCQVGFTGKEC-QWTDACLSH-PCANGSTCT-TVANQFSCK 130
Query: 316 CRPGYTGATCELGIDECD-PSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGP 374
C G+TG CE ++ECD P C++GG+C +L SY C C GF G+ C+ + CA P
Sbjct: 131 CLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSP 190
Query: 375 CFNGGRCSDSPDGGYSCRC 393
C NGG C + D + C C
Sbjct: 191 CVNGGTCRQTGDFTFECNC 209
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.139 0.476
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,965,709
Number of Sequences: 37866
Number of extensions: 2252444
Number of successful extensions: 14747
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 211
Number of HSP's successfully gapped in prelim test: 257
Number of HSP's that attempted gapping in prelim test: 4905
Number of HSP's gapped (non-prelim): 3106
length of query: 723
length of database: 18,247,518
effective HSP length: 110
effective length of query: 613
effective length of database: 14,082,258
effective search space: 8632424154
effective search space used: 8632424154
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.