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Search of human proteins with 166795254
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|166795254 ankyrin repeat domain 13C [Homo sapiens]
(541 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|166795254 ankyrin repeat domain 13C [Homo sapiens] 1092 0.0
gi|38683799 ankyrin repeat domain 13 [Homo sapiens] 253 4e-67
gi|124517699 ankyrin repeat domain 13B [Homo sapiens] 236 4e-62
gi|46409340 ankyrin repeat domain 13 family, member D [Homo sapi... 176 4e-44
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 55 1e-07
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 54 3e-07
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 52 1e-06
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 52 1e-06
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 52 1e-06
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 52 1e-06
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 52 1e-06
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 52 1e-06
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 52 1e-06
gi|22208957 ankyrin repeat and SOCS box-containing protein 13 [H... 52 2e-06
gi|140161500 ankyrin repeat and sterile alpha motif domain conta... 52 2e-06
gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2... 52 2e-06
gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1... 52 2e-06
gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3... 52 2e-06
gi|62177127 myosin heavy chain Myr 8 [Homo sapiens] 50 4e-06
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 50 5e-06
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 50 5e-06
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 49 1e-05
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens] 48 2e-05
gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens] 48 2e-05
gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens] 48 2e-05
gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens] 48 2e-05
gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens] 48 2e-05
gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens] 48 2e-05
gi|51972284 NOTCH-regulated ankyrin repeat protein [Homo sapiens] 48 2e-05
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 48 2e-05
>gi|166795254 ankyrin repeat domain 13C [Homo sapiens]
Length = 541
Score = 1092 bits (2824), Expect = 0.0
Identities = 541/541 (100%), Positives = 541/541 (100%)
Query: 1 MTGEKIRSLRRDHKPSKEEGDLLEPGDEEAAAALGGTFTRSRIGKGGKACHKIFSNHHHR 60
MTGEKIRSLRRDHKPSKEEGDLLEPGDEEAAAALGGTFTRSRIGKGGKACHKIFSNHHHR
Sbjct: 1 MTGEKIRSLRRDHKPSKEEGDLLEPGDEEAAAALGGTFTRSRIGKGGKACHKIFSNHHHR 60
Query: 61 LQLKAAPASSNPPGAPALPLHNSSVTANSQSPALLAGTNPVAVVADGGSCPAHYPVHECV 120
LQLKAAPASSNPPGAPALPLHNSSVTANSQSPALLAGTNPVAVVADGGSCPAHYPVHECV
Sbjct: 61 LQLKAAPASSNPPGAPALPLHNSSVTANSQSPALLAGTNPVAVVADGGSCPAHYPVHECV 120
Query: 121 FKGDVRRLSSLIRTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSP 180
FKGDVRRLSSLIRTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSP
Sbjct: 121 FKGDVRRLSSLIRTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSP 180
Query: 181 LAEAISYGDRQMITALLRKLKQQSRESVEEKRPRLLKALKELGDFYLELHWDFQSWVPLL 240
LAEAISYGDRQMITALLRKLKQQSRESVEEKRPRLLKALKELGDFYLELHWDFQSWVPLL
Sbjct: 181 LAEAISYGDRQMITALLRKLKQQSRESVEEKRPRLLKALKELGDFYLELHWDFQSWVPLL 240
Query: 241 SRILPSDACKIYKQGINIRLDTTLIDFTDMKCQRGDLSFIFNGDAAPSESFVVLDNEQKV 300
SRILPSDACKIYKQGINIRLDTTLIDFTDMKCQRGDLSFIFNGDAAPSESFVVLDNEQKV
Sbjct: 241 SRILPSDACKIYKQGINIRLDTTLIDFTDMKCQRGDLSFIFNGDAAPSESFVVLDNEQKV 300
Query: 301 YQRIHHEESEMETEEEVDILMSSDIYSATLSTKSISFTRAQTGWLFREDKTERVGNFLAD 360
YQRIHHEESEMETEEEVDILMSSDIYSATLSTKSISFTRAQTGWLFREDKTERVGNFLAD
Sbjct: 301 YQRIHHEESEMETEEEVDILMSSDIYSATLSTKSISFTRAQTGWLFREDKTERVGNFLAD 360
Query: 361 FYLVNGLVLESRKRREHLSEEDILRNKAIMESLSKGGNIMEQNFEPIRRQSLTPPPQNTI 420
FYLVNGLVLESRKRREHLSEEDILRNKAIMESLSKGGNIMEQNFEPIRRQSLTPPPQNTI
Sbjct: 361 FYLVNGLVLESRKRREHLSEEDILRNKAIMESLSKGGNIMEQNFEPIRRQSLTPPPQNTI 420
Query: 421 TWEEYISAENGKAPHLGRELVCKESKKTFKATIAMSQEFPLGIELLLNVLEVVAPFKHFN 480
TWEEYISAENGKAPHLGRELVCKESKKTFKATIAMSQEFPLGIELLLNVLEVVAPFKHFN
Sbjct: 421 TWEEYISAENGKAPHLGRELVCKESKKTFKATIAMSQEFPLGIELLLNVLEVVAPFKHFN 480
Query: 481 KLREFVQMKLPPGFPVKLDIPVFPTITATVTFQEFRYDEFDGSIFTIPDDYKEDPSRFPD 540
KLREFVQMKLPPGFPVKLDIPVFPTITATVTFQEFRYDEFDGSIFTIPDDYKEDPSRFPD
Sbjct: 481 KLREFVQMKLPPGFPVKLDIPVFPTITATVTFQEFRYDEFDGSIFTIPDDYKEDPSRFPD 540
Query: 541 L 541
L
Sbjct: 541 L 541
>gi|38683799 ankyrin repeat domain 13 [Homo sapiens]
Length = 590
Score = 253 bits (645), Expect = 4e-67
Identities = 151/416 (36%), Positives = 233/416 (56%), Gaps = 16/416 (3%)
Query: 113 HYPVHECVFKGDVRRLSSLIRTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKV 172
HYP+H V+K D R+L ++ N+ D G T LHLAV LG+ E A +LL H A V
Sbjct: 10 HYPLHLLVWKNDYRQLEKELQGQNVEAVDPRGRTLLHLAVSLGHLESARVLLRHKADVTK 69
Query: 173 KNAQGWSPLAEAISYGDRQMITALLRKLKQQSRESVEEKRPRLLKALKELGDFYLELHWD 232
+N QGW+ L EA+S GD +M+ +L+ + E P LL+ + E DFY+++ W+
Sbjct: 70 ENRQGWTVLHEAVSTGDPEMVYTVLQHRDYHNTSMALEGVPELLQKILEAPDFYVQMKWE 129
Query: 233 FQSWVPLLSRILPSDACKIYKQGINIRLDTTLIDFTDMKCQRGDLSFIFNGDAAPSESFV 292
F SWVPL+SRI P+D C+I+K G +R+D TL+ F +M RG SFIF G+ +E
Sbjct: 130 FTSWVPLVSRICPNDVCRIWKSGAKLRVDITLLGFENMSWIRGRRSFIFKGEDNWAELME 189
Query: 293 VLDNEQKVYQRIHHEESEME---------TEEEVDILMSSDIYSATLSTKSISFTRAQTG 343
V +++ V EME EV+ ++S + + +L TK+I+F R ++G
Sbjct: 190 VNHDDKVVTTERFDLSQEMERLTLDLMKPKSREVERRLTSPVINTSLDTKNIAFERTKSG 249
Query: 344 -WLFREDKTERVGNFLADFYLVNGLVLESRKRREHLSEEDILRNKAIMESLSKGGNIMEQ 402
W +R DK E V + A Y VN + + ++ R EHL+EE+ R KA L +E
Sbjct: 250 FWGWRTDKAEVVNGYEAKVYTVNNVNVITKIRTEHLTEEEKKRYKADRNPLESLLGTVEH 309
Query: 403 NF---EPIRRQSLTPPPQNTITWEEYISAE-NGKAPHLGRELVCKESKKTFKATIAMSQE 458
F + + T IT +EY + E + K +GR + FKA + M +E
Sbjct: 310 QFGAQGDLTTECATANNPTAITPDEYFNEEFDLKDRDIGRPKELTIRTQKFKAMLWMCEE 369
Query: 459 FPLG-IELLLNVLEVVA-PFKHFNKLREFVQMKLPPGFPVKLDIPVFPTITATVTF 512
FPL +E ++ +++++A HF +LR+F++++ PPGFPVK++IP+F + A +TF
Sbjct: 370 FPLSLVEQVIPIIDLMARTSAHFARLRDFIKLEFPPGFPVKIEIPLFHVLNARITF 425
>gi|124517699 ankyrin repeat domain 13B [Homo sapiens]
Length = 626
Score = 236 bits (602), Expect = 4e-62
Identities = 153/419 (36%), Positives = 232/419 (55%), Gaps = 21/419 (5%)
Query: 114 YPVHECVFKGDVRRLSSLIRTH--NIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVK 171
YP+H V+ R L +R +I Q D G TPLHLA LG+ ECA +LLAH A V
Sbjct: 16 YPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVG 75
Query: 172 VKNAQGWSPLAEAISYGDRQMITALLRKLKQQSRESVEEKRPRLLKALKELGDFYLELHW 231
+N GW+ L EA+S D +++ +LR Q P LL+ L++ DFY+E+ W
Sbjct: 76 RENRSGWTVLQEAVSTRDLELVQLVLRYRDYQRVVKRLAGIPVLLEKLRKAQDFYVEMKW 135
Query: 232 DFQSWVPLLSRILPSDACKIYKQGINIRLDTTLIDFTDMKCQRGDLSFIFNGDAAPSESF 291
+F SWVPL+S+I PSD K++K G N+R+DTTL+ F M QRG+ SF+F G +
Sbjct: 136 EFTSWVPLVSKICPSDTYKVWKSGQNLRVDTTLLGFDHMTWQRGNRSFVFRGQDTSAVVM 195
Query: 292 VVLDNEQKVYQR---IHHEESEM------ETEEEVDILMSSDIYSATLSTKSISFTRAQT 342
+ + + VY + ++ E+ TEE+V +++ + + L TK+ISF R +T
Sbjct: 196 EIDHDRRVVYTETLALAGQDRELLLAAAQPTEEQVLSRLTAPVVTTQLDTKNISFERNKT 255
Query: 343 GWL-FREDKTERVGNFLADFYLVNGLVLESRKRREHLSEEDILRNKAIMESLSKGGNIME 401
G L +R +KTE V + A Y + + L +R R EHLSE+ + K L I E
Sbjct: 256 GILGWRSEKTEMVNGYEAKVYGASNVELITRTRTEHLSEQHKGKVKGCKTPLQSFLGIAE 315
Query: 402 QNFEP----IRRQSLTPPPQNTITWEEYISA--ENGKAPHLGRELVCKESKKTFKATIAM 455
Q+ P + Q+L+ IT EEY + E G +GR + + FKA + +
Sbjct: 316 QHGGPQNGTLITQTLSQANPTAITAEEYFNPNFELGNR-DMGRPMELTTKTQKFKAKLWL 374
Query: 456 SQEFPLGI-ELLLNVLEVVAPFKH-FNKLREFVQMKLPPGFPVKLDIPVFPTITATVTF 512
+E PL + E + +++++A F KLR+F+ ++LPPGFPVK++IP+F + A +TF
Sbjct: 375 CEEHPLSLCEQVAPIIDLMAVSNALFAKLRDFITLRLPPGFPVKIEIPIFHILNARITF 433
>gi|46409340 ankyrin repeat domain 13 family, member D [Homo
sapiens]
Length = 518
Score = 176 bits (447), Expect = 4e-44
Identities = 109/317 (34%), Positives = 182/317 (57%), Gaps = 18/317 (5%)
Query: 213 PRLLKALKELGDFYLELHWDFQSWVPLLSRILPSDACKIYKQGINIRLDTTLIDFTDMKC 272
P LL L++ DFY+E+ W+F SWVPL+S++ PSD +++K+G ++R+DT+L+ F +
Sbjct: 22 PELLNKLRQAPDFYVEMKWEFTSWVPLVSKMCPSDVYRVWKRGESLRVDTSLLGFEHVTW 81
Query: 273 QRGDLSFIFNGDAAPSESFVVLDNEQKVY-QRIHHEESEMET--------EEEVDILMSS 323
QRG SFIF G A + V + Q V+ + + E ET EE V ++S
Sbjct: 82 QRGRRSFIFKGQEAGALVMEVDHDRQVVHVETLGLTLQEPETLLAAMRPSEEHVASRLTS 141
Query: 324 DIYSATLSTKSISFTRAQTG-WLFREDKTERVGNFLADFYLVNGLVLESRKRREHLSEED 382
I S L T++++F R + G W +R +K E V + A Y + L +R R EHLS++D
Sbjct: 142 PIVSTHLDTRNVAFERNKCGIWGWRSEKMETVSGYEAKVYSATNVELVTRTRTEHLSDQD 201
Query: 383 ILRNKAIMESLSKGGNIMEQNFE----PIRRQSLTPPPQNTITWEEYISAE-NGKAPHLG 437
R+KA + +Q+ P+ +Q+ +P I+ EEY + ++ ++G
Sbjct: 202 KSRSKAGKTPFQSFLGMAQQHSSHTGAPV-QQAASPTNPTAISPEEYFDPNFSLESRNIG 260
Query: 438 RELVCKESKKTFKATIAMSQEFPLGI-ELLLNVLEVVA-PFKHFNKLREFVQMKLPPGFP 495
R + + FKAT+ +S+E PL + + + +++++A HF KLR+F+ ++LPPGFP
Sbjct: 261 RPIEMSSKVQRFKATLWLSEEHPLSLGDQVTPIIDLMAISNAHFAKLRDFITLRLPPGFP 320
Query: 496 VKLDIPVFPTITATVTF 512
VK++IP+F + A +TF
Sbjct: 321 VKIEIPLFHVLNARITF 337
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 55.5 bits (132), Expect = 1e-07
Identities = 43/149 (28%), Positives = 67/149 (44%), Gaps = 16/149 (10%)
Query: 65 AAPASSNPPGAPALPLHNSSVTANSQSPALL-----AGTNPVAVVADGGSCP-------- 111
A S+N P + + P +SS + +S +L AG + A + G + P
Sbjct: 121 AGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVS 180
Query: 112 -AHYPVHECVFKGDVRRLSSLIRTHNIGQKDNHG--NTPLHLAVMLGNKECAHLLLAHNA 168
A + E GDV R+ L+ N+ KD G ++PLH A G K+ LL A
Sbjct: 181 GALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGA 240
Query: 169 PVKVKNAQGWSPLAEAISYGDRQMITALL 197
V ++ G PL A S+G ++++ LL
Sbjct: 241 NVHARDDGGLIPLHNACSFGHAEVVSLLL 269
Score = 50.1 bits (118), Expect = 5e-06
Identities = 30/79 (37%), Positives = 39/79 (49%), Gaps = 2/79 (2%)
Query: 122 KGDVRRLSSLIRTHNIGQKDNHG--NTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWS 179
KG + R+ L NI +D G +TPLHLA N E A LL H A V ++ G
Sbjct: 813 KGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLI 872
Query: 180 PLAEAISYGDRQMITALLR 198
PL A SYG + L++
Sbjct: 873 PLHNAASYGHVDIAALLIK 891
Score = 45.1 bits (105), Expect = 2e-04
Identities = 28/83 (33%), Positives = 38/83 (45%), Gaps = 2/83 (2%)
Query: 118 ECVFKGDVRRLSSLIRTHNIG--QKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNA 175
E G+ +L +L+ N+ D +TPLHLA LLL H A V K+
Sbjct: 341 EAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDK 400
Query: 176 QGWSPLAEAISYGDRQMITALLR 198
G PL A SYG ++ LL+
Sbjct: 401 GGLVPLHNACSYGHYEVTELLLK 423
Score = 44.7 bits (104), Expect = 2e-04
Identities = 28/87 (32%), Positives = 39/87 (44%), Gaps = 2/87 (2%)
Query: 114 YPVHECVFKGDVRRLSSLIRTHNIGQKDNHG--NTPLHLAVMLGNKECAHLLLAHNAPVK 171
Y + E GD+ + L + N+ +D G +TPLH A LL H A V
Sbjct: 652 YRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVH 711
Query: 172 VKNAQGWSPLAEAISYGDRQMITALLR 198
K+ G PL A SYG ++ L+R
Sbjct: 712 AKDKGGLVPLHNACSYGHYEVAELLVR 738
Score = 42.0 bits (97), Expect = 0.001
Identities = 24/78 (30%), Positives = 40/78 (51%)
Query: 136 NIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITA 195
++ KD G PLH A G+ E A LL+ H A V V + ++PL EA + G ++
Sbjct: 709 DVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKL 768
Query: 196 LLRKLKQQSRESVEEKRP 213
LL+ ++++ + P
Sbjct: 769 LLKHGADPTKKNRDGNTP 786
Score = 42.0 bits (97), Expect = 0.001
Identities = 44/165 (26%), Positives = 62/165 (37%), Gaps = 16/165 (9%)
Query: 21 DLLEPGDEEAAAALGGTFTRSRIGKGGKACHKIFSNHHHRLQLKAAPASSN---PPGAPA 77
DL++ GD + L G K G R+Q P + N G +
Sbjct: 788 DLVKEGDTDIQDLLRGDAALLDAAKKGCLA---------RVQKLCTPENINCRDTQGRNS 838
Query: 78 LPLHNSSVTANSQSPALLAGTNPVAVVADGGSCPAHYPVHECVFKGDVRRLSSLIRTHN- 136
PLH ++ N + L D G P+H G V + LI+ +
Sbjct: 839 TPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGL---IPLHNAASYGHVDIAALLIKYNTC 895
Query: 137 IGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPL 181
+ D TPLH A G + LLLAH A +KN +G +PL
Sbjct: 896 VNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPL 940
Score = 40.0 bits (92), Expect = 0.005
Identities = 42/154 (27%), Positives = 59/154 (38%), Gaps = 17/154 (11%)
Query: 61 LQLKAAPASSNPPGAPALPLHNSSVTA----------------NSQSPALLAGTNPVAVV 104
LQ A P N G AL L + S A + L+A P+ V
Sbjct: 302 LQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVN 361
Query: 105 ADGGSCPAHYPVHECVFKGDVRRLSSLIRTH-NIGQKDNHGNTPLHLAVMLGNKECAHLL 163
P+H VR + L++ ++ KD G PLH A G+ E LL
Sbjct: 362 CHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELL 421
Query: 164 LAHNAPVKVKNAQGWSPLAEAISYGDRQMITALL 197
L H A V + ++PL EA S ++ + LL
Sbjct: 422 LKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLL 455
Score = 39.7 bits (91), Expect = 0.007
Identities = 21/52 (40%), Positives = 26/52 (50%), Gaps = 10/52 (19%)
Query: 56 NHHHRLQLKAAPASSNPPGAPALPLHNSSVTANSQSPALLAGTNPVAVVADG 107
+HHH+ QL+ AP +S PP P PL SP L GT P + A G
Sbjct: 11 HHHHQQQLQPAPGASAPPPPPPPPL----------SPGLAPGTTPASPTASG 52
Score = 39.3 bits (90), Expect = 0.009
Identities = 37/121 (30%), Positives = 55/121 (45%), Gaps = 16/121 (13%)
Query: 106 DGGSCPAHYPVHECVFKGDVRRLSSLI-RTHNIGQKDNHGNTPLHLAVMLGNKECAHLLL 164
DGG P H + C F G +S L+ + + +DN TPLH A + G + +LL
Sbjct: 247 DGGLIPLH---NACSF-GHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLL 302
Query: 165 AHNAPVKVKNAQGWS------PLAEAISYGDRQMITALLRKLKQQSRESVEEKRPRLLKA 218
H A ++N G S P A+A+ G+ + +L + +R EEK LL
Sbjct: 303 QHGADPNIRNTDGKSALDLADPSAKAVLTGEYKK-----DELLEAARSGNEEKLMALLTP 357
Query: 219 L 219
L
Sbjct: 358 L 358
Score = 37.7 bits (86), Expect = 0.027
Identities = 22/78 (28%), Positives = 37/78 (47%)
Query: 136 NIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITA 195
++ +D G PLH A G+ + A LL+ +N V + ++PL EA G Q+
Sbjct: 862 DVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCAL 921
Query: 196 LLRKLKQQSRESVEEKRP 213
LL + ++ E + P
Sbjct: 922 LLAHGADPTMKNQEGQTP 939
Score = 33.5 bits (75), Expect = 0.51
Identities = 29/85 (34%), Positives = 36/85 (42%), Gaps = 3/85 (3%)
Query: 115 PVHECVFKGDVRRLSSLIRTH-NIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVK 173
P+H G L+R ++ D TPLH A G E LLL H A K
Sbjct: 720 PLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKK 779
Query: 174 NAQGWSPLAEAISYGDRQMITALLR 198
N G +PL + + GD I LLR
Sbjct: 780 NRDGNTPL-DLVKEGDTD-IQDLLR 802
Score = 31.6 bits (70), Expect = 1.9
Identities = 45/192 (23%), Positives = 72/192 (37%), Gaps = 17/192 (8%)
Query: 23 LEPGDEEAAAALGGTFTRSRIGKGGKACHKIFSNHHHRLQLKAAPASSN---PPGAPALP 79
L+ D A A L G + + + + + S + +L P + N G + P
Sbjct: 319 LDLADPSAKAVLTGEYKKDELLEAAR------SGNEEKLMALLTPLNVNCHASDGRKSTP 372
Query: 80 LHNSSVTANSQSPALLAGTNPVAVVADGGSCPAHYPVHECVFKGDVRRLSSLIRTHN--I 137
LH ++ + LL D G P+H G ++ L+ H +
Sbjct: 373 LHLAAGYNRVRIVQLLLQHGADVHAKDKGGL---VPLHNACSYGHYE-VTELLLKHGACV 428
Query: 138 GQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALL 197
D TPLH A E LLL+H A + N G S + A + R+ +T
Sbjct: 429 NAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEF 488
Query: 198 R--KLKQQSRES 207
+ L Q +RE+
Sbjct: 489 KGHSLLQAAREA 500
Score = 29.3 bits (64), Expect = 9.6
Identities = 17/62 (27%), Positives = 27/62 (43%)
Query: 136 NIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITA 195
N+ +K+ TPLH+A + + +L H A + + G + L A G Q
Sbjct: 550 NVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRL 609
Query: 196 LL 197
LL
Sbjct: 610 LL 611
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 54.3 bits (129), Expect = 3e-07
Identities = 30/90 (33%), Positives = 45/90 (50%), Gaps = 2/90 (2%)
Query: 111 PAHYPVHECVFKGDVRRLSSLIRTHNIGQKDNHG--NTPLHLAVMLGNKECAHLLLAHNA 168
PA + E GDV R+ L+ + +D G +TPLH A G K+ LL + A
Sbjct: 23 PAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGA 82
Query: 169 PVKVKNAQGWSPLAEAISYGDRQMITALLR 198
V+ ++ G PL A S+G +++ LLR
Sbjct: 83 NVQARDDGGLIPLHNACSFGHAEVVNLLLR 112
Score = 49.7 bits (117), Expect = 7e-06
Identities = 34/109 (31%), Positives = 49/109 (44%), Gaps = 7/109 (6%)
Query: 97 GTNPVAVVADGGS-----CPAHYPVHECVFKGDVRRLSSLIRTHNIGQKDNHG--NTPLH 149
G P+ +V DG + + + KG + R+ L N+ +D G +TPLH
Sbjct: 625 GNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLH 684
Query: 150 LAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALLR 198
LA N E A LL H A V ++ G PL A SYG + L++
Sbjct: 685 LAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIK 733
Score = 43.5 bits (101), Expect = 5e-04
Identities = 28/93 (30%), Positives = 40/93 (43%), Gaps = 2/93 (2%)
Query: 108 GSCPAHYPVHECVFKGDVRRLSSLIRTHNIGQKDNHG--NTPLHLAVMLGNKECAHLLLA 165
G+ A + E GDV + L ++ +D G +TPLH A LL
Sbjct: 488 GNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQ 547
Query: 166 HNAPVKVKNAQGWSPLAEAISYGDRQMITALLR 198
H A V K+ G PL A SYG ++ L++
Sbjct: 548 HGADVHAKDKGGLVPLHNACSYGHYEVAELLVK 580
Score = 41.2 bits (95), Expect = 0.002
Identities = 24/78 (30%), Positives = 40/78 (51%)
Query: 136 NIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITA 195
++ KD G PLH A G+ E A LL+ H A V V + ++PL EA + G ++
Sbjct: 551 DVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKL 610
Query: 196 LLRKLKQQSRESVEEKRP 213
LL+ ++++ + P
Sbjct: 611 LLQHGADPTKKNRDGNTP 628
Score = 40.4 bits (93), Expect = 0.004
Identities = 25/83 (30%), Positives = 38/83 (45%), Gaps = 2/83 (2%)
Query: 118 ECVFKGDVRRLSSLIRTHNIG--QKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNA 175
E G+ ++ +L+ N+ D +TPLHLA + LLL H A V K+
Sbjct: 183 ESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDK 242
Query: 176 QGWSPLAEAISYGDRQMITALLR 198
PL A SYG ++ L++
Sbjct: 243 GDLVPLHNACSYGHYEVTELLVK 265
Score = 40.4 bits (93), Expect = 0.004
Identities = 48/181 (26%), Positives = 73/181 (40%), Gaps = 20/181 (11%)
Query: 21 DLLEPGDEEAAAALGGTFTRSRIGKGGKACHKIFSNHHHRLQLKAAPASSN---PPGAPA 77
DL++ GD + L G K G R++ ++P + N G +
Sbjct: 630 DLVKDGDTDIQDLLRGDAALLDAAKKGCLA---------RVKKLSSPDNVNCRDTQGRHS 680
Query: 78 LPLHNSSVTANSQSPALLAGTNPVAVVADGGSCPAHYPVHECVFKGDVRRLSSLIRTHN- 136
PLH ++ N + L D G P+H G V + LI+ +
Sbjct: 681 TPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGL---IPLHNAASYGHVDVAALLIKYNAC 737
Query: 137 IGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITAL 196
+ D TPLH A G + LLLAH A +KN +G +PL + +S D ++AL
Sbjct: 738 VNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPL-DLVSADD---VSAL 793
Query: 197 L 197
L
Sbjct: 794 L 794
Score = 39.3 bits (90), Expect = 0.009
Identities = 45/160 (28%), Positives = 68/160 (42%), Gaps = 19/160 (11%)
Query: 69 SSNPPGAPALPLHNSSVTANSQSPALLA--GTNPVAVVADGGSCPAHYPVHECVFKGDVR 126
S + G + PLH ++ L G N V DGG P H + C F G
Sbjct: 51 SRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGAN-VQARDDGGLIPLH---NACSF-GHAE 105
Query: 127 RLSSLIRTH-NIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWS------ 179
++ L+R + +DN TPLH A + G + +LL H A ++N G +
Sbjct: 106 VVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLAD 165
Query: 180 PLAEAISYGDRQMITALLRKLKQQSRESVEEKRPRLLKAL 219
P A+A+ G+ + +L + +R EEK LL L
Sbjct: 166 PSAKAVLTGEYKK-----DELLESARSGNEEKMMALLTPL 200
Score = 38.9 bits (89), Expect = 0.012
Identities = 23/78 (29%), Positives = 38/78 (48%)
Query: 136 NIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITA 195
++ +D G PLH A G+ + A LL+ +NA V + ++PL EA G Q+
Sbjct: 704 DVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCAL 763
Query: 196 LLRKLKQQSRESVEEKRP 213
LL + ++ E + P
Sbjct: 764 LLAHGADPTLKNQEGQTP 781
Score = 35.4 bits (80), Expect = 0.13
Identities = 38/154 (24%), Positives = 58/154 (37%), Gaps = 17/154 (11%)
Query: 61 LQLKAAPASSNPPGAPALPLHNSSVTA----------------NSQSPALLAGTNPVAVV 104
LQ A P N G AL L + S A + ++A P+ V
Sbjct: 144 LQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVN 203
Query: 105 ADGGSCPAHYPVHECVFKGDVRRLSSLIRTH-NIGQKDNHGNTPLHLAVMLGNKECAHLL 163
P+H V+ + L++ ++ KD PLH A G+ E LL
Sbjct: 204 CHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELL 263
Query: 164 LAHNAPVKVKNAQGWSPLAEAISYGDRQMITALL 197
+ H A V + ++PL EA S ++ + LL
Sbjct: 264 VKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLL 297
Score = 33.9 bits (76), Expect = 0.39
Identities = 29/110 (26%), Positives = 45/110 (40%), Gaps = 21/110 (19%)
Query: 112 AHYPVHECVFKGDVRRLSSLIRTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVK 171
AH V E V K + + + DN G T LH A G+ + LLL++
Sbjct: 411 AHNDVVEVVVKHEAK----------VNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPN 460
Query: 172 VKNAQGWSP-----------LAEAISYGDRQMITALLRKLKQQSRESVEE 210
+ + QG++ L E IS G+ + LL K E+V++
Sbjct: 461 IISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKK 510
Score = 32.3 bits (72), Expect = 1.1
Identities = 23/53 (43%), Positives = 26/53 (49%), Gaps = 2/53 (3%)
Query: 146 TPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALLR 198
TPLH A G E LLL H A KN G +PL + + GD I LLR
Sbjct: 594 TPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPL-DLVKDGDTD-IQDLLR 644
Score = 29.3 bits (64), Expect = 9.6
Identities = 18/62 (29%), Positives = 27/62 (43%)
Query: 136 NIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITA 195
NI +K TPLH+A + + +++ H A V + G + L A G Q
Sbjct: 392 NINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRL 451
Query: 196 LL 197
LL
Sbjct: 452 LL 453
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 52.4 bits (124), Expect = 1e-06
Identities = 34/109 (31%), Positives = 55/109 (50%), Gaps = 1/109 (0%)
Query: 115 PVHECVFKGDVRRLSSLIRTH-NIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVK 173
P+H +GDV+++ LI N+ KD G TPLH A +G + A +L+A A V +
Sbjct: 165 PLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQ 224
Query: 174 NAQGWSPLAEAISYGDRQMITALLRKLKQQSRESVEEKRPRLLKALKEL 222
+PL ++ S G R ++ LLR + + +RP + +EL
Sbjct: 225 GLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEEL 273
Score = 44.3 bits (103), Expect = 3e-04
Identities = 23/85 (27%), Positives = 44/85 (51%)
Query: 129 SSLIRTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYG 188
SS + + +++ G TPLH+A + G+ + L++ A V VK+ GW+PL EA + G
Sbjct: 147 SSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVG 206
Query: 189 DRQMITALLRKLKQQSRESVEEKRP 213
+ L+ + + +++ P
Sbjct: 207 YYDVAKILIAAGADVNTQGLDDDTP 231
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 52.4 bits (124), Expect = 1e-06
Identities = 34/109 (31%), Positives = 55/109 (50%), Gaps = 1/109 (0%)
Query: 115 PVHECVFKGDVRRLSSLIRTH-NIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVK 173
P+H +GDV+++ LI N+ KD G TPLH A +G + A +L+A A V +
Sbjct: 188 PLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQ 247
Query: 174 NAQGWSPLAEAISYGDRQMITALLRKLKQQSRESVEEKRPRLLKALKEL 222
+PL ++ S G R ++ LLR + + +RP + +EL
Sbjct: 248 GLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEEL 296
Score = 44.3 bits (103), Expect = 3e-04
Identities = 23/85 (27%), Positives = 44/85 (51%)
Query: 129 SSLIRTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYG 188
SS + + +++ G TPLH+A + G+ + L++ A V VK+ GW+PL EA + G
Sbjct: 170 SSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVG 229
Query: 189 DRQMITALLRKLKQQSRESVEEKRP 213
+ L+ + + +++ P
Sbjct: 230 YYDVAKILIAAGADVNTQGLDDDTP 254
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 52.4 bits (124), Expect = 1e-06
Identities = 45/157 (28%), Positives = 65/157 (41%), Gaps = 28/157 (17%)
Query: 79 PLHNSSVTANSQSPALL------------AGTNPVAVVADGGSCPAHYPVHECVFKGDVR 126
PLH ++ +++ ALL +G P+ +VA G H PV + + K V
Sbjct: 671 PLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEG----HVPVADVLIKHGVM 726
Query: 127 RLSSLIRTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAIS 186
+ G TPLH+A GN + LL H A V K G+SPL +A
Sbjct: 727 ----------VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQ 776
Query: 187 YGDRQMITALLRKLKQQSRESVEEKRPRLLKALKELG 223
G ++T LL+ + S + P L K LG
Sbjct: 777 QGHTDIVTLLLKNGASPNEVSSDGTTP--LAIAKRLG 811
Score = 40.4 bits (93), Expect = 0.004
Identities = 50/188 (26%), Positives = 72/188 (38%), Gaps = 19/188 (10%)
Query: 22 LLEPGDEEAAAALGGTFTRSRIGKGGKACHKIFSNHHH--RLQLKAAPASSNPPGAPALP 79
LL+ G + + AL G FT I AC K NH L LK + + P
Sbjct: 390 LLDKGAKPNSRALNG-FTPLHI-----ACKK---NHVRVMELLLKTGASIDAVTESGLTP 440
Query: 80 LHNSSVTANSQ--SPALLAGTNPVAVVADGGSCPAHYPVHECVFKGDVRRLSSLIRTH-N 136
LH +S + L G +P + + P+H G L++
Sbjct: 441 LHVASFMGHLPIVKNLLQRGASP-----NVSNVKVETPLHMAARAGHTEVAKYLLQNKAK 495
Query: 137 IGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITAL 196
+ K TPLH A +G+ LLL +NA + G +PL A G + + AL
Sbjct: 496 VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLAL 555
Query: 197 LRKLKQQS 204
L K Q+
Sbjct: 556 LEKEASQA 563
Score = 39.7 bits (91), Expect = 0.007
Identities = 29/112 (25%), Positives = 48/112 (42%), Gaps = 7/112 (6%)
Query: 93 ALLAGTNPVAVVADGGSCP------AHYPVHECVFKGDVRRLSSLIRTH-NIGQKDNHGN 145
A + TN V ++ + + P H P+H +G V + +L+ + G
Sbjct: 511 ARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF 570
Query: 146 TPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALL 197
TPLH+A G A LLL +A G +PL A+ + + ++ LL
Sbjct: 571 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 622
Score = 39.3 bits (90), Expect = 0.009
Identities = 28/84 (33%), Positives = 40/84 (47%), Gaps = 2/84 (2%)
Query: 115 PVHECVFKGDVRRLSSLI-RTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVK 173
P+H +G+V + L+ R I K TPLH A G+ + +LL H AP++ K
Sbjct: 275 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 334
Query: 174 NAQGWSPLAEAISYGDRQMITALL 197
G SP+ A + GD LL
Sbjct: 335 TKNGLSPIHMA-AQGDHLDCVRLL 357
Score = 38.5 bits (88), Expect = 0.016
Identities = 27/100 (27%), Positives = 47/100 (47%), Gaps = 1/100 (1%)
Query: 115 PVHECVFKGDVRRLSSLIRTH-NIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVK 173
P+H K VR + L++T +I G TPLH+A +G+ LL A V
Sbjct: 407 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 466
Query: 174 NAQGWSPLAEAISYGDRQMITALLRKLKQQSRESVEEKRP 213
N + +PL A G ++ LL+ + + ++ +++ P
Sbjct: 467 NVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTP 506
Score = 38.1 bits (87), Expect = 0.021
Identities = 20/57 (35%), Positives = 28/57 (49%)
Query: 143 HGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALLRK 199
+G TPLH+A E A LL + ++ QG +PL A G +M+ LL K
Sbjct: 634 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 690
Score = 36.6 bits (83), Expect = 0.060
Identities = 18/62 (29%), Positives = 30/62 (48%)
Query: 136 NIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITA 195
N+ + G TPL++A + E LL + A V G++PLA A+ G ++
Sbjct: 136 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 195
Query: 196 LL 197
L+
Sbjct: 196 LI 197
Score = 36.6 bits (83), Expect = 0.060
Identities = 25/87 (28%), Positives = 41/87 (47%), Gaps = 3/87 (3%)
Query: 115 PVHECVFKGDVRRLSSLIRTHN--IGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKV 172
P+H G VR +S ++ H I K +G +P+H+A + +C LLL ++A +
Sbjct: 308 PLHCAARNGHVR-ISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 366
Query: 173 KNAQGWSPLAEAISYGDRQMITALLRK 199
+PL A G ++ LL K
Sbjct: 367 ITLDHLTPLHVAAHCGHHRVAKVLLDK 393
Score = 35.4 bits (80), Expect = 0.13
Identities = 37/142 (26%), Positives = 57/142 (40%), Gaps = 10/142 (7%)
Query: 61 LQLKAAPASSNPPGAPALPLHNSSVTANSQ-SPALLAGTNPVAVVADGGSCPAHYPVHEC 119
LQ A+P SN PLH ++ +++ + LL V A P H C
Sbjct: 457 LQRGASPNVSNVK--VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLH-----C 509
Query: 120 VFKGDVRRLSSLIRTHNIGQK--DNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQG 177
+ + L+ +N G+TPLH+A G+ E LL A +G
Sbjct: 510 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 569
Query: 178 WSPLAEAISYGDRQMITALLRK 199
++PL A YG ++ LL +
Sbjct: 570 FTPLHVAAKYGKVRVAELLLER 591
Score = 35.0 bits (79), Expect = 0.17
Identities = 18/61 (29%), Positives = 31/61 (50%)
Query: 144 GNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALLRKLKQQ 203
GNT LH+A + G E L+ + A V ++ +G++PL A +++ LL Q
Sbjct: 111 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 170
Query: 204 S 204
+
Sbjct: 171 N 171
Score = 34.7 bits (78), Expect = 0.23
Identities = 24/70 (34%), Positives = 32/70 (45%)
Query: 144 GNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALLRKLKQQ 203
G TPLH+A N A LLL A V G +PL A G+ M+ LL + Q
Sbjct: 239 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 298
Query: 204 SRESVEEKRP 213
++ +E P
Sbjct: 299 ETKTKDELTP 308
Score = 34.7 bits (78), Expect = 0.23
Identities = 30/105 (28%), Positives = 44/105 (41%), Gaps = 1/105 (0%)
Query: 115 PVHECVFKGDVRRLSSLI-RTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVK 173
P+H G VR L+ R + +G TPLH+AV N + LLL
Sbjct: 572 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 631
Query: 174 NAQGWSPLAEAISYGDRQMITALLRKLKQQSRESVEEKRPRLLKA 218
G++PL A ++ +LL+ + ESV+ P L A
Sbjct: 632 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA 676
Score = 33.9 bits (76), Expect = 0.39
Identities = 22/68 (32%), Positives = 32/68 (47%), Gaps = 1/68 (1%)
Query: 115 PVHECVFKGDVRRLSSLIRTHNIGQKDN-HGNTPLHLAVMLGNKECAHLLLAHNAPVKVK 173
P+H + V SL++ ++ G TPLHLA G+ E LLL+ A +
Sbjct: 638 PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 697
Query: 174 NAQGWSPL 181
N G +PL
Sbjct: 698 NKSGLTPL 705
Score = 33.5 bits (75), Expect = 0.51
Identities = 36/126 (28%), Positives = 57/126 (45%), Gaps = 5/126 (3%)
Query: 74 GAPALP-LHNSSVTANSQSPALLAGTNPVA-VVADGGSCPAHYPVHECVFKGDVRRLSSL 131
G LP LH ++ ++++ A+L +P V++ G P H H +V +L L
Sbjct: 203 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAH--YENLNVAQLL-L 259
Query: 132 IRTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQ 191
R ++ +G TPLH+A GN LLL A ++ K +PL A G +
Sbjct: 260 NRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 319
Query: 192 MITALL 197
+ LL
Sbjct: 320 ISEILL 325
Score = 30.4 bits (67), Expect = 4.3
Identities = 27/103 (26%), Positives = 43/103 (41%), Gaps = 7/103 (6%)
Query: 115 PVHECVFKGDVRRLSSLIRTHNIGQKDN----HGNTPLHLAVMLGNKECAHLLLAHNAPV 170
P+H G R L+ + G K N +G TPLH+A + LLL A +
Sbjct: 374 PLHVAAHCGHHRVAKVLL---DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI 430
Query: 171 KVKNAQGWSPLAEAISYGDRQMITALLRKLKQQSRESVEEKRP 213
G +PL A G ++ LL++ + +V+ + P
Sbjct: 431 DAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 473
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 52.4 bits (124), Expect = 1e-06
Identities = 45/157 (28%), Positives = 65/157 (41%), Gaps = 28/157 (17%)
Query: 79 PLHNSSVTANSQSPALL------------AGTNPVAVVADGGSCPAHYPVHECVFKGDVR 126
PLH ++ +++ ALL +G P+ +VA G H PV + + K V
Sbjct: 638 PLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEG----HVPVADVLIKHGVM 693
Query: 127 RLSSLIRTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAIS 186
+ G TPLH+A GN + LL H A V K G+SPL +A
Sbjct: 694 ----------VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQ 743
Query: 187 YGDRQMITALLRKLKQQSRESVEEKRPRLLKALKELG 223
G ++T LL+ + S + P L K LG
Sbjct: 744 QGHTDIVTLLLKNGASPNEVSSDGTTP--LAIAKRLG 778
Score = 40.4 bits (93), Expect = 0.004
Identities = 50/188 (26%), Positives = 72/188 (38%), Gaps = 19/188 (10%)
Query: 22 LLEPGDEEAAAALGGTFTRSRIGKGGKACHKIFSNHHH--RLQLKAAPASSNPPGAPALP 79
LL+ G + + AL G FT I AC K NH L LK + + P
Sbjct: 357 LLDKGAKPNSRALNG-FTPLHI-----ACKK---NHVRVMELLLKTGASIDAVTESGLTP 407
Query: 80 LHNSSVTANSQ--SPALLAGTNPVAVVADGGSCPAHYPVHECVFKGDVRRLSSLIRTH-N 136
LH +S + L G +P + + P+H G L++
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASP-----NVSNVKVETPLHMAARAGHTEVAKYLLQNKAK 462
Query: 137 IGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITAL 196
+ K TPLH A +G+ LLL +NA + G +PL A G + + AL
Sbjct: 463 VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLAL 522
Query: 197 LRKLKQQS 204
L K Q+
Sbjct: 523 LEKEASQA 530
Score = 39.7 bits (91), Expect = 0.007
Identities = 29/112 (25%), Positives = 48/112 (42%), Gaps = 7/112 (6%)
Query: 93 ALLAGTNPVAVVADGGSCP------AHYPVHECVFKGDVRRLSSLIRTH-NIGQKDNHGN 145
A + TN V ++ + + P H P+H +G V + +L+ + G
Sbjct: 478 ARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF 537
Query: 146 TPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALL 197
TPLH+A G A LLL +A G +PL A+ + + ++ LL
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589
Score = 39.3 bits (90), Expect = 0.009
Identities = 28/84 (33%), Positives = 40/84 (47%), Gaps = 2/84 (2%)
Query: 115 PVHECVFKGDVRRLSSLI-RTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVK 173
P+H +G+V + L+ R I K TPLH A G+ + +LL H AP++ K
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 301
Query: 174 NAQGWSPLAEAISYGDRQMITALL 197
G SP+ A + GD LL
Sbjct: 302 TKNGLSPIHMA-AQGDHLDCVRLL 324
Score = 38.5 bits (88), Expect = 0.016
Identities = 27/100 (27%), Positives = 47/100 (47%), Gaps = 1/100 (1%)
Query: 115 PVHECVFKGDVRRLSSLIRTH-NIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVK 173
P+H K VR + L++T +I G TPLH+A +G+ LL A V
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433
Query: 174 NAQGWSPLAEAISYGDRQMITALLRKLKQQSRESVEEKRP 213
N + +PL A G ++ LL+ + + ++ +++ P
Sbjct: 434 NVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTP 473
Score = 38.1 bits (87), Expect = 0.021
Identities = 20/57 (35%), Positives = 28/57 (49%)
Query: 143 HGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALLRK 199
+G TPLH+A E A LL + ++ QG +PL A G +M+ LL K
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 657
Score = 36.6 bits (83), Expect = 0.060
Identities = 18/62 (29%), Positives = 30/62 (48%)
Query: 136 NIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITA 195
N+ + G TPL++A + E LL + A V G++PLA A+ G ++
Sbjct: 103 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 162
Query: 196 LL 197
L+
Sbjct: 163 LI 164
Score = 36.6 bits (83), Expect = 0.060
Identities = 25/87 (28%), Positives = 41/87 (47%), Gaps = 3/87 (3%)
Query: 115 PVHECVFKGDVRRLSSLIRTHN--IGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKV 172
P+H G VR +S ++ H I K +G +P+H+A + +C LLL ++A +
Sbjct: 275 PLHCAARNGHVR-ISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 173 KNAQGWSPLAEAISYGDRQMITALLRK 199
+PL A G ++ LL K
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Score = 35.4 bits (80), Expect = 0.13
Identities = 37/142 (26%), Positives = 57/142 (40%), Gaps = 10/142 (7%)
Query: 61 LQLKAAPASSNPPGAPALPLHNSSVTANSQ-SPALLAGTNPVAVVADGGSCPAHYPVHEC 119
LQ A+P SN PLH ++ +++ + LL V A P H C
Sbjct: 424 LQRGASPNVSNVK--VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLH-----C 476
Query: 120 VFKGDVRRLSSLIRTHNIGQK--DNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQG 177
+ + L+ +N G+TPLH+A G+ E LL A +G
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 178 WSPLAEAISYGDRQMITALLRK 199
++PL A YG ++ LL +
Sbjct: 537 FTPLHVAAKYGKVRVAELLLER 558
Score = 35.0 bits (79), Expect = 0.17
Identities = 18/61 (29%), Positives = 31/61 (50%)
Query: 144 GNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALLRKLKQQ 203
GNT LH+A + G E L+ + A V ++ +G++PL A +++ LL Q
Sbjct: 78 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137
Query: 204 S 204
+
Sbjct: 138 N 138
Score = 34.7 bits (78), Expect = 0.23
Identities = 24/70 (34%), Positives = 32/70 (45%)
Query: 144 GNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALLRKLKQQ 203
G TPLH+A N A LLL A V G +PL A G+ M+ LL + Q
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 204 SRESVEEKRP 213
++ +E P
Sbjct: 266 ETKTKDELTP 275
Score = 34.7 bits (78), Expect = 0.23
Identities = 30/105 (28%), Positives = 44/105 (41%), Gaps = 1/105 (0%)
Query: 115 PVHECVFKGDVRRLSSLI-RTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVK 173
P+H G VR L+ R + +G TPLH+AV N + LLL
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 598
Query: 174 NAQGWSPLAEAISYGDRQMITALLRKLKQQSRESVEEKRPRLLKA 218
G++PL A ++ +LL+ + ESV+ P L A
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA 643
Score = 33.9 bits (76), Expect = 0.39
Identities = 22/68 (32%), Positives = 32/68 (47%), Gaps = 1/68 (1%)
Query: 115 PVHECVFKGDVRRLSSLIRTHNIGQKDN-HGNTPLHLAVMLGNKECAHLLLAHNAPVKVK 173
P+H + V SL++ ++ G TPLHLA G+ E LLL+ A +
Sbjct: 605 PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664
Query: 174 NAQGWSPL 181
N G +PL
Sbjct: 665 NKSGLTPL 672
Score = 33.5 bits (75), Expect = 0.51
Identities = 36/126 (28%), Positives = 57/126 (45%), Gaps = 5/126 (3%)
Query: 74 GAPALP-LHNSSVTANSQSPALLAGTNPVA-VVADGGSCPAHYPVHECVFKGDVRRLSSL 131
G LP LH ++ ++++ A+L +P V++ G P H H +V +L L
Sbjct: 170 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAH--YENLNVAQLL-L 226
Query: 132 IRTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQ 191
R ++ +G TPLH+A GN LLL A ++ K +PL A G +
Sbjct: 227 NRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 286
Query: 192 MITALL 197
+ LL
Sbjct: 287 ISEILL 292
Score = 30.4 bits (67), Expect = 4.3
Identities = 27/103 (26%), Positives = 43/103 (41%), Gaps = 7/103 (6%)
Query: 115 PVHECVFKGDVRRLSSLIRTHNIGQKDN----HGNTPLHLAVMLGNKECAHLLLAHNAPV 170
P+H G R L+ + G K N +G TPLH+A + LLL A +
Sbjct: 341 PLHVAAHCGHHRVAKVLL---DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI 397
Query: 171 KVKNAQGWSPLAEAISYGDRQMITALLRKLKQQSRESVEEKRP 213
G +PL A G ++ LL++ + +V+ + P
Sbjct: 398 DAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 440
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 52.4 bits (124), Expect = 1e-06
Identities = 45/157 (28%), Positives = 65/157 (41%), Gaps = 28/157 (17%)
Query: 79 PLHNSSVTANSQSPALL------------AGTNPVAVVADGGSCPAHYPVHECVFKGDVR 126
PLH ++ +++ ALL +G P+ +VA G H PV + + K V
Sbjct: 638 PLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEG----HVPVADVLIKHGVM 693
Query: 127 RLSSLIRTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAIS 186
+ G TPLH+A GN + LL H A V K G+SPL +A
Sbjct: 694 ----------VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQ 743
Query: 187 YGDRQMITALLRKLKQQSRESVEEKRPRLLKALKELG 223
G ++T LL+ + S + P L K LG
Sbjct: 744 QGHTDIVTLLLKNGASPNEVSSDGTTP--LAIAKRLG 778
Score = 40.4 bits (93), Expect = 0.004
Identities = 50/188 (26%), Positives = 72/188 (38%), Gaps = 19/188 (10%)
Query: 22 LLEPGDEEAAAALGGTFTRSRIGKGGKACHKIFSNHHH--RLQLKAAPASSNPPGAPALP 79
LL+ G + + AL G FT I AC K NH L LK + + P
Sbjct: 357 LLDKGAKPNSRALNG-FTPLHI-----ACKK---NHVRVMELLLKTGASIDAVTESGLTP 407
Query: 80 LHNSSVTANSQ--SPALLAGTNPVAVVADGGSCPAHYPVHECVFKGDVRRLSSLIRTH-N 136
LH +S + L G +P + + P+H G L++
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASP-----NVSNVKVETPLHMAARAGHTEVAKYLLQNKAK 462
Query: 137 IGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITAL 196
+ K TPLH A +G+ LLL +NA + G +PL A G + + AL
Sbjct: 463 VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLAL 522
Query: 197 LRKLKQQS 204
L K Q+
Sbjct: 523 LEKEASQA 530
Score = 39.7 bits (91), Expect = 0.007
Identities = 29/112 (25%), Positives = 48/112 (42%), Gaps = 7/112 (6%)
Query: 93 ALLAGTNPVAVVADGGSCP------AHYPVHECVFKGDVRRLSSLIRTH-NIGQKDNHGN 145
A + TN V ++ + + P H P+H +G V + +L+ + G
Sbjct: 478 ARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF 537
Query: 146 TPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALL 197
TPLH+A G A LLL +A G +PL A+ + + ++ LL
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589
Score = 39.3 bits (90), Expect = 0.009
Identities = 28/84 (33%), Positives = 40/84 (47%), Gaps = 2/84 (2%)
Query: 115 PVHECVFKGDVRRLSSLI-RTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVK 173
P+H +G+V + L+ R I K TPLH A G+ + +LL H AP++ K
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 301
Query: 174 NAQGWSPLAEAISYGDRQMITALL 197
G SP+ A + GD LL
Sbjct: 302 TKNGLSPIHMA-AQGDHLDCVRLL 324
Score = 38.5 bits (88), Expect = 0.016
Identities = 27/100 (27%), Positives = 47/100 (47%), Gaps = 1/100 (1%)
Query: 115 PVHECVFKGDVRRLSSLIRTH-NIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVK 173
P+H K VR + L++T +I G TPLH+A +G+ LL A V
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433
Query: 174 NAQGWSPLAEAISYGDRQMITALLRKLKQQSRESVEEKRP 213
N + +PL A G ++ LL+ + + ++ +++ P
Sbjct: 434 NVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTP 473
Score = 38.1 bits (87), Expect = 0.021
Identities = 20/57 (35%), Positives = 28/57 (49%)
Query: 143 HGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALLRK 199
+G TPLH+A E A LL + ++ QG +PL A G +M+ LL K
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 657
Score = 36.6 bits (83), Expect = 0.060
Identities = 18/62 (29%), Positives = 30/62 (48%)
Query: 136 NIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITA 195
N+ + G TPL++A + E LL + A V G++PLA A+ G ++
Sbjct: 103 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 162
Query: 196 LL 197
L+
Sbjct: 163 LI 164
Score = 36.6 bits (83), Expect = 0.060
Identities = 25/87 (28%), Positives = 41/87 (47%), Gaps = 3/87 (3%)
Query: 115 PVHECVFKGDVRRLSSLIRTHN--IGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKV 172
P+H G VR +S ++ H I K +G +P+H+A + +C LLL ++A +
Sbjct: 275 PLHCAARNGHVR-ISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 173 KNAQGWSPLAEAISYGDRQMITALLRK 199
+PL A G ++ LL K
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Score = 35.4 bits (80), Expect = 0.13
Identities = 37/142 (26%), Positives = 57/142 (40%), Gaps = 10/142 (7%)
Query: 61 LQLKAAPASSNPPGAPALPLHNSSVTANSQ-SPALLAGTNPVAVVADGGSCPAHYPVHEC 119
LQ A+P SN PLH ++ +++ + LL V A P H C
Sbjct: 424 LQRGASPNVSNVK--VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLH-----C 476
Query: 120 VFKGDVRRLSSLIRTHNIGQK--DNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQG 177
+ + L+ +N G+TPLH+A G+ E LL A +G
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 178 WSPLAEAISYGDRQMITALLRK 199
++PL A YG ++ LL +
Sbjct: 537 FTPLHVAAKYGKVRVAELLLER 558
Score = 35.0 bits (79), Expect = 0.17
Identities = 18/61 (29%), Positives = 31/61 (50%)
Query: 144 GNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALLRKLKQQ 203
GNT LH+A + G E L+ + A V ++ +G++PL A +++ LL Q
Sbjct: 78 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137
Query: 204 S 204
+
Sbjct: 138 N 138
Score = 34.7 bits (78), Expect = 0.23
Identities = 24/70 (34%), Positives = 32/70 (45%)
Query: 144 GNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALLRKLKQQ 203
G TPLH+A N A LLL A V G +PL A G+ M+ LL + Q
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 204 SRESVEEKRP 213
++ +E P
Sbjct: 266 ETKTKDELTP 275
Score = 34.7 bits (78), Expect = 0.23
Identities = 30/105 (28%), Positives = 44/105 (41%), Gaps = 1/105 (0%)
Query: 115 PVHECVFKGDVRRLSSLI-RTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVK 173
P+H G VR L+ R + +G TPLH+AV N + LLL
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 598
Query: 174 NAQGWSPLAEAISYGDRQMITALLRKLKQQSRESVEEKRPRLLKA 218
G++PL A ++ +LL+ + ESV+ P L A
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA 643
Score = 33.9 bits (76), Expect = 0.39
Identities = 22/68 (32%), Positives = 32/68 (47%), Gaps = 1/68 (1%)
Query: 115 PVHECVFKGDVRRLSSLIRTHNIGQKDN-HGNTPLHLAVMLGNKECAHLLLAHNAPVKVK 173
P+H + V SL++ ++ G TPLHLA G+ E LLL+ A +
Sbjct: 605 PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664
Query: 174 NAQGWSPL 181
N G +PL
Sbjct: 665 NKSGLTPL 672
Score = 33.5 bits (75), Expect = 0.51
Identities = 36/126 (28%), Positives = 57/126 (45%), Gaps = 5/126 (3%)
Query: 74 GAPALP-LHNSSVTANSQSPALLAGTNPVA-VVADGGSCPAHYPVHECVFKGDVRRLSSL 131
G LP LH ++ ++++ A+L +P V++ G P H H +V +L L
Sbjct: 170 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAH--YENLNVAQLL-L 226
Query: 132 IRTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQ 191
R ++ +G TPLH+A GN LLL A ++ K +PL A G +
Sbjct: 227 NRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 286
Query: 192 MITALL 197
+ LL
Sbjct: 287 ISEILL 292
Score = 30.4 bits (67), Expect = 4.3
Identities = 27/103 (26%), Positives = 43/103 (41%), Gaps = 7/103 (6%)
Query: 115 PVHECVFKGDVRRLSSLIRTHNIGQKDN----HGNTPLHLAVMLGNKECAHLLLAHNAPV 170
P+H G R L+ + G K N +G TPLH+A + LLL A +
Sbjct: 341 PLHVAAHCGHHRVAKVLL---DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI 397
Query: 171 KVKNAQGWSPLAEAISYGDRQMITALLRKLKQQSRESVEEKRP 213
G +PL A G ++ LL++ + +V+ + P
Sbjct: 398 DAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 440
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 52.4 bits (124), Expect = 1e-06
Identities = 45/157 (28%), Positives = 65/157 (41%), Gaps = 28/157 (17%)
Query: 79 PLHNSSVTANSQSPALL------------AGTNPVAVVADGGSCPAHYPVHECVFKGDVR 126
PLH ++ +++ ALL +G P+ +VA G H PV + + K V
Sbjct: 638 PLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEG----HVPVADVLIKHGVM 693
Query: 127 RLSSLIRTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAIS 186
+ G TPLH+A GN + LL H A V K G+SPL +A
Sbjct: 694 ----------VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQ 743
Query: 187 YGDRQMITALLRKLKQQSRESVEEKRPRLLKALKELG 223
G ++T LL+ + S + P L K LG
Sbjct: 744 QGHTDIVTLLLKNGASPNEVSSDGTTP--LAIAKRLG 778
Score = 40.4 bits (93), Expect = 0.004
Identities = 50/188 (26%), Positives = 72/188 (38%), Gaps = 19/188 (10%)
Query: 22 LLEPGDEEAAAALGGTFTRSRIGKGGKACHKIFSNHHH--RLQLKAAPASSNPPGAPALP 79
LL+ G + + AL G FT I AC K NH L LK + + P
Sbjct: 357 LLDKGAKPNSRALNG-FTPLHI-----ACKK---NHVRVMELLLKTGASIDAVTESGLTP 407
Query: 80 LHNSSVTANSQ--SPALLAGTNPVAVVADGGSCPAHYPVHECVFKGDVRRLSSLIRTH-N 136
LH +S + L G +P + + P+H G L++
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASP-----NVSNVKVETPLHMAARAGHTEVAKYLLQNKAK 462
Query: 137 IGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITAL 196
+ K TPLH A +G+ LLL +NA + G +PL A G + + AL
Sbjct: 463 VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLAL 522
Query: 197 LRKLKQQS 204
L K Q+
Sbjct: 523 LEKEASQA 530
Score = 39.7 bits (91), Expect = 0.007
Identities = 29/112 (25%), Positives = 48/112 (42%), Gaps = 7/112 (6%)
Query: 93 ALLAGTNPVAVVADGGSCP------AHYPVHECVFKGDVRRLSSLIRTH-NIGQKDNHGN 145
A + TN V ++ + + P H P+H +G V + +L+ + G
Sbjct: 478 ARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF 537
Query: 146 TPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALL 197
TPLH+A G A LLL +A G +PL A+ + + ++ LL
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589
Score = 39.3 bits (90), Expect = 0.009
Identities = 28/84 (33%), Positives = 40/84 (47%), Gaps = 2/84 (2%)
Query: 115 PVHECVFKGDVRRLSSLI-RTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVK 173
P+H +G+V + L+ R I K TPLH A G+ + +LL H AP++ K
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 301
Query: 174 NAQGWSPLAEAISYGDRQMITALL 197
G SP+ A + GD LL
Sbjct: 302 TKNGLSPIHMA-AQGDHLDCVRLL 324
Score = 38.5 bits (88), Expect = 0.016
Identities = 27/100 (27%), Positives = 47/100 (47%), Gaps = 1/100 (1%)
Query: 115 PVHECVFKGDVRRLSSLIRTH-NIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVK 173
P+H K VR + L++T +I G TPLH+A +G+ LL A V
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433
Query: 174 NAQGWSPLAEAISYGDRQMITALLRKLKQQSRESVEEKRP 213
N + +PL A G ++ LL+ + + ++ +++ P
Sbjct: 434 NVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTP 473
Score = 38.1 bits (87), Expect = 0.021
Identities = 20/57 (35%), Positives = 28/57 (49%)
Query: 143 HGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALLRK 199
+G TPLH+A E A LL + ++ QG +PL A G +M+ LL K
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 657
Score = 36.6 bits (83), Expect = 0.060
Identities = 18/62 (29%), Positives = 30/62 (48%)
Query: 136 NIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITA 195
N+ + G TPL++A + E LL + A V G++PLA A+ G ++
Sbjct: 103 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 162
Query: 196 LL 197
L+
Sbjct: 163 LI 164
Score = 36.6 bits (83), Expect = 0.060
Identities = 25/87 (28%), Positives = 41/87 (47%), Gaps = 3/87 (3%)
Query: 115 PVHECVFKGDVRRLSSLIRTHN--IGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKV 172
P+H G VR +S ++ H I K +G +P+H+A + +C LLL ++A +
Sbjct: 275 PLHCAARNGHVR-ISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 173 KNAQGWSPLAEAISYGDRQMITALLRK 199
+PL A G ++ LL K
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Score = 35.4 bits (80), Expect = 0.13
Identities = 37/142 (26%), Positives = 57/142 (40%), Gaps = 10/142 (7%)
Query: 61 LQLKAAPASSNPPGAPALPLHNSSVTANSQ-SPALLAGTNPVAVVADGGSCPAHYPVHEC 119
LQ A+P SN PLH ++ +++ + LL V A P H C
Sbjct: 424 LQRGASPNVSNVK--VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLH-----C 476
Query: 120 VFKGDVRRLSSLIRTHNIGQK--DNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQG 177
+ + L+ +N G+TPLH+A G+ E LL A +G
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 178 WSPLAEAISYGDRQMITALLRK 199
++PL A YG ++ LL +
Sbjct: 537 FTPLHVAAKYGKVRVAELLLER 558
Score = 35.0 bits (79), Expect = 0.17
Identities = 18/61 (29%), Positives = 31/61 (50%)
Query: 144 GNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALLRKLKQQ 203
GNT LH+A + G E L+ + A V ++ +G++PL A +++ LL Q
Sbjct: 78 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137
Query: 204 S 204
+
Sbjct: 138 N 138
Score = 34.7 bits (78), Expect = 0.23
Identities = 24/70 (34%), Positives = 32/70 (45%)
Query: 144 GNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALLRKLKQQ 203
G TPLH+A N A LLL A V G +PL A G+ M+ LL + Q
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 204 SRESVEEKRP 213
++ +E P
Sbjct: 266 ETKTKDELTP 275
Score = 34.7 bits (78), Expect = 0.23
Identities = 30/105 (28%), Positives = 44/105 (41%), Gaps = 1/105 (0%)
Query: 115 PVHECVFKGDVRRLSSLI-RTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVK 173
P+H G VR L+ R + +G TPLH+AV N + LLL
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 598
Query: 174 NAQGWSPLAEAISYGDRQMITALLRKLKQQSRESVEEKRPRLLKA 218
G++PL A ++ +LL+ + ESV+ P L A
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA 643
Score = 33.9 bits (76), Expect = 0.39
Identities = 22/68 (32%), Positives = 32/68 (47%), Gaps = 1/68 (1%)
Query: 115 PVHECVFKGDVRRLSSLIRTHNIGQKDN-HGNTPLHLAVMLGNKECAHLLLAHNAPVKVK 173
P+H + V SL++ ++ G TPLHLA G+ E LLL+ A +
Sbjct: 605 PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664
Query: 174 NAQGWSPL 181
N G +PL
Sbjct: 665 NKSGLTPL 672
Score = 33.5 bits (75), Expect = 0.51
Identities = 36/126 (28%), Positives = 57/126 (45%), Gaps = 5/126 (3%)
Query: 74 GAPALP-LHNSSVTANSQSPALLAGTNPVA-VVADGGSCPAHYPVHECVFKGDVRRLSSL 131
G LP LH ++ ++++ A+L +P V++ G P H H +V +L L
Sbjct: 170 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAH--YENLNVAQLL-L 226
Query: 132 IRTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQ 191
R ++ +G TPLH+A GN LLL A ++ K +PL A G +
Sbjct: 227 NRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 286
Query: 192 MITALL 197
+ LL
Sbjct: 287 ISEILL 292
Score = 30.4 bits (67), Expect = 4.3
Identities = 27/103 (26%), Positives = 43/103 (41%), Gaps = 7/103 (6%)
Query: 115 PVHECVFKGDVRRLSSLIRTHNIGQKDN----HGNTPLHLAVMLGNKECAHLLLAHNAPV 170
P+H G R L+ + G K N +G TPLH+A + LLL A +
Sbjct: 341 PLHVAAHCGHHRVAKVLL---DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI 397
Query: 171 KVKNAQGWSPLAEAISYGDRQMITALLRKLKQQSRESVEEKRP 213
G +PL A G ++ LL++ + +V+ + P
Sbjct: 398 DAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 440
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 52.4 bits (124), Expect = 1e-06
Identities = 45/157 (28%), Positives = 65/157 (41%), Gaps = 28/157 (17%)
Query: 79 PLHNSSVTANSQSPALL------------AGTNPVAVVADGGSCPAHYPVHECVFKGDVR 126
PLH ++ +++ ALL +G P+ +VA G H PV + + K V
Sbjct: 638 PLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEG----HVPVADVLIKHGVM 693
Query: 127 RLSSLIRTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAIS 186
+ G TPLH+A GN + LL H A V K G+SPL +A
Sbjct: 694 ----------VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQ 743
Query: 187 YGDRQMITALLRKLKQQSRESVEEKRPRLLKALKELG 223
G ++T LL+ + S + P L K LG
Sbjct: 744 QGHTDIVTLLLKNGASPNEVSSDGTTP--LAIAKRLG 778
Score = 40.4 bits (93), Expect = 0.004
Identities = 50/188 (26%), Positives = 72/188 (38%), Gaps = 19/188 (10%)
Query: 22 LLEPGDEEAAAALGGTFTRSRIGKGGKACHKIFSNHHH--RLQLKAAPASSNPPGAPALP 79
LL+ G + + AL G FT I AC K NH L LK + + P
Sbjct: 357 LLDKGAKPNSRALNG-FTPLHI-----ACKK---NHVRVMELLLKTGASIDAVTESGLTP 407
Query: 80 LHNSSVTANSQ--SPALLAGTNPVAVVADGGSCPAHYPVHECVFKGDVRRLSSLIRTH-N 136
LH +S + L G +P + + P+H G L++
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASP-----NVSNVKVETPLHMAARAGHTEVAKYLLQNKAK 462
Query: 137 IGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITAL 196
+ K TPLH A +G+ LLL +NA + G +PL A G + + AL
Sbjct: 463 VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLAL 522
Query: 197 LRKLKQQS 204
L K Q+
Sbjct: 523 LEKEASQA 530
Score = 39.7 bits (91), Expect = 0.007
Identities = 29/112 (25%), Positives = 48/112 (42%), Gaps = 7/112 (6%)
Query: 93 ALLAGTNPVAVVADGGSCP------AHYPVHECVFKGDVRRLSSLIRTH-NIGQKDNHGN 145
A + TN V ++ + + P H P+H +G V + +L+ + G
Sbjct: 478 ARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF 537
Query: 146 TPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALL 197
TPLH+A G A LLL +A G +PL A+ + + ++ LL
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589
Score = 39.3 bits (90), Expect = 0.009
Identities = 28/84 (33%), Positives = 40/84 (47%), Gaps = 2/84 (2%)
Query: 115 PVHECVFKGDVRRLSSLI-RTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVK 173
P+H +G+V + L+ R I K TPLH A G+ + +LL H AP++ K
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 301
Query: 174 NAQGWSPLAEAISYGDRQMITALL 197
G SP+ A + GD LL
Sbjct: 302 TKNGLSPIHMA-AQGDHLDCVRLL 324
Score = 38.5 bits (88), Expect = 0.016
Identities = 27/100 (27%), Positives = 47/100 (47%), Gaps = 1/100 (1%)
Query: 115 PVHECVFKGDVRRLSSLIRTH-NIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVK 173
P+H K VR + L++T +I G TPLH+A +G+ LL A V
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433
Query: 174 NAQGWSPLAEAISYGDRQMITALLRKLKQQSRESVEEKRP 213
N + +PL A G ++ LL+ + + ++ +++ P
Sbjct: 434 NVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTP 473
Score = 38.1 bits (87), Expect = 0.021
Identities = 20/57 (35%), Positives = 28/57 (49%)
Query: 143 HGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALLRK 199
+G TPLH+A E A LL + ++ QG +PL A G +M+ LL K
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 657
Score = 36.6 bits (83), Expect = 0.060
Identities = 18/62 (29%), Positives = 30/62 (48%)
Query: 136 NIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITA 195
N+ + G TPL++A + E LL + A V G++PLA A+ G ++
Sbjct: 103 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 162
Query: 196 LL 197
L+
Sbjct: 163 LI 164
Score = 36.6 bits (83), Expect = 0.060
Identities = 25/87 (28%), Positives = 41/87 (47%), Gaps = 3/87 (3%)
Query: 115 PVHECVFKGDVRRLSSLIRTHN--IGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKV 172
P+H G VR +S ++ H I K +G +P+H+A + +C LLL ++A +
Sbjct: 275 PLHCAARNGHVR-ISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 173 KNAQGWSPLAEAISYGDRQMITALLRK 199
+PL A G ++ LL K
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Score = 35.4 bits (80), Expect = 0.13
Identities = 37/142 (26%), Positives = 57/142 (40%), Gaps = 10/142 (7%)
Query: 61 LQLKAAPASSNPPGAPALPLHNSSVTANSQ-SPALLAGTNPVAVVADGGSCPAHYPVHEC 119
LQ A+P SN PLH ++ +++ + LL V A P H C
Sbjct: 424 LQRGASPNVSNVK--VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLH-----C 476
Query: 120 VFKGDVRRLSSLIRTHNIGQK--DNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQG 177
+ + L+ +N G+TPLH+A G+ E LL A +G
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 178 WSPLAEAISYGDRQMITALLRK 199
++PL A YG ++ LL +
Sbjct: 537 FTPLHVAAKYGKVRVAELLLER 558
Score = 35.0 bits (79), Expect = 0.17
Identities = 18/61 (29%), Positives = 31/61 (50%)
Query: 144 GNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALLRKLKQQ 203
GNT LH+A + G E L+ + A V ++ +G++PL A +++ LL Q
Sbjct: 78 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137
Query: 204 S 204
+
Sbjct: 138 N 138
Score = 34.7 bits (78), Expect = 0.23
Identities = 24/70 (34%), Positives = 32/70 (45%)
Query: 144 GNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALLRKLKQQ 203
G TPLH+A N A LLL A V G +PL A G+ M+ LL + Q
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 204 SRESVEEKRP 213
++ +E P
Sbjct: 266 ETKTKDELTP 275
Score = 34.7 bits (78), Expect = 0.23
Identities = 30/105 (28%), Positives = 44/105 (41%), Gaps = 1/105 (0%)
Query: 115 PVHECVFKGDVRRLSSLI-RTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVK 173
P+H G VR L+ R + +G TPLH+AV N + LLL
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 598
Query: 174 NAQGWSPLAEAISYGDRQMITALLRKLKQQSRESVEEKRPRLLKA 218
G++PL A ++ +LL+ + ESV+ P L A
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA 643
Score = 33.9 bits (76), Expect = 0.39
Identities = 22/68 (32%), Positives = 32/68 (47%), Gaps = 1/68 (1%)
Query: 115 PVHECVFKGDVRRLSSLIRTHNIGQKDN-HGNTPLHLAVMLGNKECAHLLLAHNAPVKVK 173
P+H + V SL++ ++ G TPLHLA G+ E LLL+ A +
Sbjct: 605 PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664
Query: 174 NAQGWSPL 181
N G +PL
Sbjct: 665 NKSGLTPL 672
Score = 33.5 bits (75), Expect = 0.51
Identities = 36/126 (28%), Positives = 57/126 (45%), Gaps = 5/126 (3%)
Query: 74 GAPALP-LHNSSVTANSQSPALLAGTNPVA-VVADGGSCPAHYPVHECVFKGDVRRLSSL 131
G LP LH ++ ++++ A+L +P V++ G P H H +V +L L
Sbjct: 170 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAH--YENLNVAQLL-L 226
Query: 132 IRTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQ 191
R ++ +G TPLH+A GN LLL A ++ K +PL A G +
Sbjct: 227 NRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 286
Query: 192 MITALL 197
+ LL
Sbjct: 287 ISEILL 292
Score = 30.4 bits (67), Expect = 4.3
Identities = 27/103 (26%), Positives = 43/103 (41%), Gaps = 7/103 (6%)
Query: 115 PVHECVFKGDVRRLSSLIRTHNIGQKDN----HGNTPLHLAVMLGNKECAHLLLAHNAPV 170
P+H G R L+ + G K N +G TPLH+A + LLL A +
Sbjct: 341 PLHVAAHCGHHRVAKVLL---DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI 397
Query: 171 KVKNAQGWSPLAEAISYGDRQMITALLRKLKQQSRESVEEKRP 213
G +PL A G ++ LL++ + +V+ + P
Sbjct: 398 DAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 440
>gi|22208957 ankyrin repeat and SOCS box-containing protein 13 [Homo
sapiens]
Length = 278
Score = 51.6 bits (122), Expect = 2e-06
Identities = 32/95 (33%), Positives = 45/95 (47%), Gaps = 1/95 (1%)
Query: 104 VADGGSCPAHYPVHECVFKGDVRRLSSLIRTHN-IGQKDNHGNTPLHLAVMLGNKECAHL 162
+ D G PVHE +G+ +L LI + + Q TPLH A + G C L
Sbjct: 11 LGDVGFWVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQL 70
Query: 163 LLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALL 197
LLA A V +N G +PL +A + G + + LL
Sbjct: 71 LLAAGAQVDARNIDGSTPLCDACASGSIECVKLLL 105
Score = 33.1 bits (74), Expect = 0.66
Identities = 33/124 (26%), Positives = 54/124 (43%), Gaps = 13/124 (10%)
Query: 79 PLHNSSVTANSQSPALL--AGTNPVAVVADGGSCPAHYPVHECVFKGDVRRLSSLIRTHN 136
PLH +S+ ++ LL AG A DG + P+ + G + + L+ +
Sbjct: 55 PLHAASLQGQARCVQLLLAAGAQVDARNIDGST-----PLCDACASGSIECVKLLL---S 106
Query: 137 IGQKDN---HGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMI 193
G K N + +PLH A M G+ EC LL+ A ++ + +PL A + +
Sbjct: 107 YGAKVNPPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCV 166
Query: 194 TALL 197
LL
Sbjct: 167 KVLL 170
Score = 30.0 bits (66), Expect = 5.6
Identities = 26/114 (22%), Positives = 46/114 (40%), Gaps = 5/114 (4%)
Query: 68 ASSNPPGAPALPLHNSSVTANSQSPALLAGTNPVAVVADGGSCPAHYPVHECVFKGDVRR 127
A NPP A PLH + ++ +S+ LL V + C P+H + +
Sbjct: 109 AKVNPPLYTASPLHEACMSGSSECVRLLI---DVGANLEAHDCHFGTPLHVACAREHLDC 165
Query: 128 LSSLIRT-HNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSP 180
+ L+ N+ H T LH A + N + +L+ + ++ +G P
Sbjct: 166 VKVLLNAGANVNAAKLH-ETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKP 218
>gi|140161500 ankyrin repeat and sterile alpha motif domain
containing 1 [Homo sapiens]
Length = 1134
Score = 51.6 bits (122), Expect = 2e-06
Identities = 34/123 (27%), Positives = 60/123 (48%), Gaps = 7/123 (5%)
Query: 79 PLHNSSVTANSQSPALLAGTNPVAVVADGGSCPAHYPVHECVFKGDVRRLSSLIR---TH 135
PLH++++ + +L + + VAD C YP+H +KGD + + LI +H
Sbjct: 83 PLHHAALNGHKDVVEVLLRNDALTNVADSKGC---YPLHLAAWKGDAQIVRLLIHQGPSH 139
Query: 136 N-IGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMIT 194
+ +++N T LH A G+ E +LL ++N + +PL A YG +++
Sbjct: 140 TRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVK 199
Query: 195 ALL 197
LL
Sbjct: 200 MLL 202
Score = 45.1 bits (105), Expect = 2e-04
Identities = 26/78 (33%), Positives = 43/78 (55%)
Query: 128 LSSLIRTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISY 187
L S+ R N+ D+ G TPLH A + G+K+ +LL ++A V +++G PL A
Sbjct: 64 LLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWK 123
Query: 188 GDRQMITALLRKLKQQSR 205
GD Q++ L+ + +R
Sbjct: 124 GDAQIVRLLIHQGPSHTR 141
Score = 30.0 bits (66), Expect = 5.6
Identities = 23/84 (27%), Positives = 36/84 (42%), Gaps = 2/84 (2%)
Query: 115 PVHECVFKGDVRRLSSLIRTH-NIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVK 173
P+ G + + L+ H N+ + +TPLHLA G+K +LL +
Sbjct: 185 PLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQ 244
Query: 174 NAQGWSPLAEAISYGDRQMITALL 197
G S L EA +G ++ LL
Sbjct: 245 TEMG-SALHEAALFGKTDVVQILL 267
>gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2
[Homo sapiens]
Length = 474
Score = 51.6 bits (122), Expect = 2e-06
Identities = 42/128 (32%), Positives = 60/128 (46%), Gaps = 12/128 (9%)
Query: 61 LQLKAAPASSNPPGAPALPLHNSSVTANSQSP--ALLAGTNPVAVVADGGSCPAHYPVHE 118
L+ +A P S+ P G AL H + ++ L+AG +P DG P+H
Sbjct: 181 LRRRARPDSA-PGGRTAL--HEACAAGHTACVHVLLVAGADPNIADQDGKR-----PLHL 232
Query: 119 CVFKGDVRRLSSLIR--THNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQ 176
C G + L+R G+ + TPLH+A LG+ E A LLL A +NA+
Sbjct: 233 CRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAE 292
Query: 177 GWSPLAEA 184
GW+PL A
Sbjct: 293 GWTPLLAA 300
Score = 41.6 bits (96), Expect = 0.002
Identities = 43/158 (27%), Positives = 58/158 (36%), Gaps = 15/158 (9%)
Query: 115 PVHECVFKGDVRRLSSLIRTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKN 174
P+H +G L L+R G T LH A G+ C H+LL A + +
Sbjct: 164 PLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIAD 223
Query: 175 AQGWSPLAEAISYGDRQMITALLRKLKQQSRESVEEKRPRLLKALK----ELGDFYLEL- 229
G PL G + LLR + S EE+ L A + EL D L
Sbjct: 224 QDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRG 283
Query: 230 ----HWDFQSWVPLLSRILPSDACKIYKQGINIRLDTT 263
+ + W PLL+ AC + Q I TT
Sbjct: 284 ACPDARNAEGWTPLLA------ACDVRCQSITDAEATT 315
>gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1
[Homo sapiens]
Length = 512
Score = 51.6 bits (122), Expect = 2e-06
Identities = 42/128 (32%), Positives = 60/128 (46%), Gaps = 12/128 (9%)
Query: 61 LQLKAAPASSNPPGAPALPLHNSSVTANSQSP--ALLAGTNPVAVVADGGSCPAHYPVHE 118
L+ +A P S+ P G AL H + ++ L+AG +P DG P+H
Sbjct: 181 LRRRARPDSA-PGGRTAL--HEACAAGHTACVHVLLVAGADPNIADQDGKR-----PLHL 232
Query: 119 CVFKGDVRRLSSLIR--THNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQ 176
C G + L+R G+ + TPLH+A LG+ E A LLL A +NA+
Sbjct: 233 CRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAE 292
Query: 177 GWSPLAEA 184
GW+PL A
Sbjct: 293 GWTPLLAA 300
Score = 41.6 bits (96), Expect = 0.002
Identities = 43/158 (27%), Positives = 58/158 (36%), Gaps = 15/158 (9%)
Query: 115 PVHECVFKGDVRRLSSLIRTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKN 174
P+H +G L L+R G T LH A G+ C H+LL A + +
Sbjct: 164 PLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIAD 223
Query: 175 AQGWSPLAEAISYGDRQMITALLRKLKQQSRESVEEKRPRLLKALK----ELGDFYLEL- 229
G PL G + LLR + S EE+ L A + EL D L
Sbjct: 224 QDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRG 283
Query: 230 ----HWDFQSWVPLLSRILPSDACKIYKQGINIRLDTT 263
+ + W PLL+ AC + Q I TT
Sbjct: 284 ACPDARNAEGWTPLLA------ACDVRCQSITDAEATT 315
>gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3
[Homo sapiens]
Length = 452
Score = 51.6 bits (122), Expect = 2e-06
Identities = 42/128 (32%), Positives = 60/128 (46%), Gaps = 12/128 (9%)
Query: 61 LQLKAAPASSNPPGAPALPLHNSSVTANSQSP--ALLAGTNPVAVVADGGSCPAHYPVHE 118
L+ +A P S+ P G AL H + ++ L+AG +P DG P+H
Sbjct: 121 LRRRARPDSA-PGGRTAL--HEACAAGHTACVHVLLVAGADPNIADQDGKR-----PLHL 172
Query: 119 CVFKGDVRRLSSLIR--THNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQ 176
C G + L+R G+ + TPLH+A LG+ E A LLL A +NA+
Sbjct: 173 CRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAE 232
Query: 177 GWSPLAEA 184
GW+PL A
Sbjct: 233 GWTPLLAA 240
Score = 41.6 bits (96), Expect = 0.002
Identities = 43/158 (27%), Positives = 58/158 (36%), Gaps = 15/158 (9%)
Query: 115 PVHECVFKGDVRRLSSLIRTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKN 174
P+H +G L L+R G T LH A G+ C H+LL A + +
Sbjct: 104 PLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIAD 163
Query: 175 AQGWSPLAEAISYGDRQMITALLRKLKQQSRESVEEKRPRLLKALK----ELGDFYLEL- 229
G PL G + LLR + S EE+ L A + EL D L
Sbjct: 164 QDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRG 223
Query: 230 ----HWDFQSWVPLLSRILPSDACKIYKQGINIRLDTT 263
+ + W PLL+ AC + Q I TT
Sbjct: 224 ACPDARNAEGWTPLLA------ACDVRCQSITDAEATT 255
>gi|62177127 myosin heavy chain Myr 8 [Homo sapiens]
Length = 1858
Score = 50.4 bits (119), Expect = 4e-06
Identities = 30/114 (26%), Positives = 54/114 (47%), Gaps = 2/114 (1%)
Query: 136 NIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITA 195
N+ +K++ G T LH+A G KE L+L H + + + Q W+PL A YG ++
Sbjct: 214 NVNEKNDEGVTLLHMACASGYKEVVSLILEHGGDLNIVDDQYWTPLHLAAKYGQTNLVKL 273
Query: 196 LLRKLKQQSRESVEEKRPRLLKALKELGDFYL--ELHWDFQSWVPLLSRILPSD 247
LL + E++ + A + + + L E+ W+ + PL + L +
Sbjct: 274 LLMHQANPHLVNCNEEKASDIAASEFIEEMLLKAEIAWEEKMKEPLSASTLAQE 327
Score = 35.4 bits (80), Expect = 0.13
Identities = 34/132 (25%), Positives = 57/132 (43%), Gaps = 8/132 (6%)
Query: 94 LLAGTNPVAVVADGGSCPAHYPVHECVFKGDVRRLSSLI-RTHNIGQKDNHGNTPLHLAV 152
L G +P +V+ GGS +H C + LI R N+ +D TP+H+A
Sbjct: 80 LKEGADPHTLVSSGGSL-----LHLCARYDNAFIAEILIDRGVNVNHQDEDFWTPMHIAC 134
Query: 153 MLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALLRKLKQQSRESVEEKR 212
N + LL+ A V +++ G PL A+ + I LL L + + ++
Sbjct: 135 ACDNPDIVLLLVLAGANVLLQDVNGNIPLDYAVEGTESSSI--LLTYLDENGVDLTSLRQ 192
Query: 213 PRLLKALKELGD 224
+L + + L D
Sbjct: 193 MKLQRPMSMLTD 204
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 50.1 bits (118), Expect = 5e-06
Identities = 33/106 (31%), Positives = 56/106 (52%), Gaps = 6/106 (5%)
Query: 94 LLAGTNPVAVVADGGSCPAHYPVHECVFKGDVRRLSSLIRTH-NIGQKDNHGNTPLHLAV 152
+L G P + +G + +H V+K + ++SL+ + +I Q G T LH+A
Sbjct: 88 MLKGLRPSRLTRNGFTA-----LHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIAT 142
Query: 153 MLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALLR 198
+ G+ E A +LL H A V +++A ++PL A YG Q+ LL+
Sbjct: 143 IAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLK 188
Score = 32.0 bits (71), Expect = 1.5
Identities = 19/53 (35%), Positives = 26/53 (49%)
Query: 136 NIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYG 188
N+ +D TPLH+A G+++ LLL A V V G PL A + G
Sbjct: 159 NVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKG 211
>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
Length = 936
Score = 50.1 bits (118), Expect = 5e-06
Identities = 33/106 (31%), Positives = 56/106 (52%), Gaps = 6/106 (5%)
Query: 94 LLAGTNPVAVVADGGSCPAHYPVHECVFKGDVRRLSSLIRTH-NIGQKDNHGNTPLHLAV 152
+L G P + +G + +H V+K + ++SL+ + +I Q G T LH+A
Sbjct: 189 MLKGLRPSRLTRNGFTA-----LHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIAT 243
Query: 153 MLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALLR 198
+ G+ E A +LL H A V +++A ++PL A YG Q+ LL+
Sbjct: 244 IAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLK 289
Score = 32.0 bits (71), Expect = 1.5
Identities = 19/53 (35%), Positives = 26/53 (49%)
Query: 136 NIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYG 188
N+ +D TPLH+A G+++ LLL A V V G PL A + G
Sbjct: 260 NVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKG 312
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 48.9 bits (115), Expect = 1e-05
Identities = 32/121 (26%), Positives = 57/121 (47%), Gaps = 1/121 (0%)
Query: 79 PLHNSSVTANSQSPALLAGTNPVAVVADGGSCPAHYPVHECVFKGDVRRLSSLI-RTHNI 137
P+H ++ +S+ LL G D P+ V G + SL+ + N+
Sbjct: 620 PIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANV 679
Query: 138 GQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALL 197
KD G T LH + G++EC LL H A +++++G +P+ + + G ++ ALL
Sbjct: 680 DAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALL 739
Query: 198 R 198
+
Sbjct: 740 Q 740
Score = 48.1 bits (113), Expect = 2e-05
Identities = 34/131 (25%), Positives = 60/131 (45%), Gaps = 8/131 (6%)
Query: 118 ECVFKGDVRRLSSLI-RTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQ 176
+ +F GD + +LI + ++ +DN TPLH A LG+ E LL+ A V K+++
Sbjct: 14 QAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSK 73
Query: 177 GWSPLAEAISYGDRQMITALLRKLKQQSRESVEEKRPRLLKALKELGDFYLELHWDFQSW 236
+PL A++ + + LL+ + + P + A + ++
Sbjct: 74 WLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKC-------AEAL 126
Query: 237 VPLLSRILPSD 247
VPLLS + SD
Sbjct: 127 VPLLSNVNVSD 137
Score = 46.2 bits (108), Expect = 8e-05
Identities = 29/89 (32%), Positives = 40/89 (44%), Gaps = 3/89 (3%)
Query: 112 AHYPVHECVFKGDVRRLSSLIRTHN---IGQKDNHGNTPLHLAVMLGNKECAHLLLAHNA 168
A P+H V + LI T + D+ G TPLH A + EC LLL+HNA
Sbjct: 788 AFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNA 847
Query: 169 PVKVKNAQGWSPLAEAISYGDRQMITALL 197
V ++ G +PL A G + L+
Sbjct: 848 QVNSVDSTGKTPLMMAAENGQTNTVEMLV 876
Score = 43.9 bits (102), Expect = 4e-04
Identities = 39/149 (26%), Positives = 59/149 (39%), Gaps = 14/149 (9%)
Query: 63 LKAAPASSNPPGAPALPLHNSSVTA---NSQSPALLAGTNPVAVVADG----------GS 109
L A AS + L H++ V A N Q+P +A N A+
Sbjct: 78 LHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSD 137
Query: 110 CPAHYPVHECVFKGDVRRLSSLI-RTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNA 168
+H F G + L+ R NI D +H A +G+ E LL++H A
Sbjct: 138 RAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGA 197
Query: 169 PVKVKNAQGWSPLAEAISYGDRQMITALL 197
V K+ + ++PL A S G ++ LL
Sbjct: 198 EVTCKDKKSYTPLHAAASSGMISVVKYLL 226
Score = 40.4 bits (93), Expect = 0.004
Identities = 31/137 (22%), Positives = 68/137 (49%), Gaps = 6/137 (4%)
Query: 89 SQSPA-LLAGTNPVAVVADGGSCPAHYPVHECVFKGDVRRLSSLIRTH-NIGQKDNHGNT 146
S++P +L T+ +++D + P+H + G + L L+++ ++ +++ G T
Sbjct: 526 SETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRT 585
Query: 147 PLHLAVMLGNKECAHLLLAHNAPVKVKN-AQGWSPLAEAISYGDRQMITALLRKLKQQSR 205
PL LA G+ EC +L+ A + VK+ +P+ A + G + + L+ + Q+
Sbjct: 586 PLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNA 645
Query: 206 ESVEE---KRPRLLKAL 219
+++ + P +L L
Sbjct: 646 VDIQDGNGQTPLMLSVL 662
Score = 38.5 bits (88), Expect = 0.016
Identities = 21/89 (23%), Positives = 37/89 (41%)
Query: 136 NIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITA 195
++ K G TPLH+ + G + ++ A + ++ G +PL A YG +I
Sbjct: 298 DVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINT 357
Query: 196 LLRKLKQQSRESVEEKRPRLLKALKELGD 224
L+ ++ + P L AL D
Sbjct: 358 LITSGADTAKRGIHGMFPLHLAALSGFSD 386
Score = 38.5 bits (88), Expect = 0.016
Identities = 28/85 (32%), Positives = 40/85 (47%), Gaps = 1/85 (1%)
Query: 114 YPVHECVFKGDVRRLSSLIRT-HNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKV 172
+P+H G L+ + +I D+ G T LH A GN EC +LLL A
Sbjct: 374 FPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNK 433
Query: 173 KNAQGWSPLAEAISYGDRQMITALL 197
K+ G SPL A + + Q + AL+
Sbjct: 434 KDKFGRSPLHYAAANCNYQCLFALV 458
Score = 35.8 bits (81), Expect = 0.10
Identities = 26/85 (30%), Positives = 41/85 (48%), Gaps = 2/85 (2%)
Query: 116 VHECVFKGDVRRLSSLIRTH-NIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKN 174
+H G++ L+ L+ T + +KD G +PLH A N +C L+ A V +
Sbjct: 409 LHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLD 468
Query: 175 AQGWSPL-AEAISYGDRQMITALLR 198
+G +PL A S D + + LLR
Sbjct: 469 ERGCTPLHYAATSDTDGKCLEYLLR 493
Score = 35.8 bits (81), Expect = 0.10
Identities = 30/111 (27%), Positives = 46/111 (41%), Gaps = 9/111 (8%)
Query: 80 LHNSSVTANSQSPALLAGTNPVAVVADGGSCPAHYPVHECVFKGDVRRLSSLIRTH---- 135
LH +VT + + L ++ D P+H G + L +L+++
Sbjct: 690 LHRGAVTGHEECVDALLQHGAKCLLRDSRG---RTPIHLSAACGHIGVLGALLQSAASMD 746
Query: 136 -NIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAI 185
N DNHG T LH A G++ C LLL K + +SPL A+
Sbjct: 747 ANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTE-GNAFSPLHCAV 796
Score = 35.4 bits (80), Expect = 0.13
Identities = 30/114 (26%), Positives = 51/114 (44%), Gaps = 7/114 (6%)
Query: 80 LHNSSVTANSQSPALLAGTNPVAVVADG-GSCPAHYPVHECVFKGDVRRLSSLIRTH-NI 137
LH ++ N + LL T D G P HY C ++ L +L+ + ++
Sbjct: 409 LHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQC----LFALVGSGASV 464
Query: 138 GQKDNHGNTPLHLAVMLGNK-ECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDR 190
D G TPLH A +C LL ++A +++ QG++ + + +YG R
Sbjct: 465 NDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHR 518
Score = 35.0 bits (79), Expect = 0.17
Identities = 23/80 (28%), Positives = 42/80 (52%), Gaps = 3/80 (3%)
Query: 112 AHYPVHECVFKGDVRRLSSLIRTH-NIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPV 170
++ P+H G + + L+ ++ + + +GNTPLH+A G + L+ A V
Sbjct: 206 SYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIV 265
Query: 171 KVKNAQGWSPL--AEAISYG 188
KN +G++PL A A ++G
Sbjct: 266 NQKNEKGFTPLHFAAASTHG 285
Score = 34.3 bits (77), Expect = 0.30
Identities = 22/86 (25%), Positives = 40/86 (46%), Gaps = 1/86 (1%)
Query: 115 PVHECVFKGDVRRLSSLIR-THNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVK 173
P+H V + L++ + ++ +D + TPLH+A +CA L+ + V V
Sbjct: 77 PLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVS 136
Query: 174 NAQGWSPLAEAISYGDRQMITALLRK 199
+ G + L A G +M+ LL +
Sbjct: 137 DRAGRTALHHAAFSGHGEMVKLLLSR 162
Score = 32.7 bits (73), Expect = 0.87
Identities = 22/84 (26%), Positives = 40/84 (47%), Gaps = 1/84 (1%)
Query: 115 PVHECVFKGDVRRLSSLIRTH-NIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVK 173
P+H G +++LI + + ++ HG PLHLA + G +C LL+ +
Sbjct: 342 PLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTP 401
Query: 174 NAQGWSPLAEAISYGDRQMITALL 197
+ G + L A + G+ + + LL
Sbjct: 402 DDFGRTCLHAAAAGGNLECLNLLL 425
Score = 30.0 bits (66), Expect = 5.6
Identities = 50/198 (25%), Positives = 70/198 (35%), Gaps = 47/198 (23%)
Query: 17 KEEGDLLEP------GDEEAAA-----ALGGTFTRSRIGKGGKACHKI-FSNHHHRLQLK 64
K EG+ P D E AA LG + + KG H F++H LQL
Sbjct: 783 KTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQL- 841
Query: 65 AAPASSNPPGAPALPLHNSSVTANSQSPALLAGTNPVAVVADGGSCPAHYPVHECVFKGD 124
L HN+ V + + G P+ + A+ G
Sbjct: 842 -------------LLSHNAQVNSVDST-----GKTPLMMAAENGQT------------NT 871
Query: 125 VRRLSSLIRTHNIGQKDNHGNTPLHLAVMLGNKECAHLLL---AHNAPVKVKNAQGWSPL 181
V L S + +DN NT LHLA G++ A L+L + NA +PL
Sbjct: 872 VEMLVSSASAE-LTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPL 930
Query: 182 AEAISYGDRQMITALLRK 199
A G ++ LL K
Sbjct: 931 HVAARNGLTMVVQELLGK 948
>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
Length = 983
Score = 48.1 bits (113), Expect = 2e-05
Identities = 35/107 (32%), Positives = 46/107 (42%), Gaps = 5/107 (4%)
Query: 94 LLAGTNPVAVVADGGSCPAHYPVHECVFKGDVRRLSSLIRTHN-IGQKDNHGNTPLHLAV 152
LL P V G HY + G ++ + L + I KD GN PL LAV
Sbjct: 108 LLQSKCPAESVDSSGKTALHYAAAQ----GCLQAVQILCEHKSPINLKDLDGNIPLLLAV 163
Query: 153 MLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALLRK 199
G+ E H LL H A V +N G + L A G + AL++K
Sbjct: 164 QNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKK 210
Score = 40.8 bits (94), Expect = 0.003
Identities = 23/83 (27%), Positives = 40/83 (48%), Gaps = 2/83 (2%)
Query: 118 ECVFKGDVRRLSSLI--RTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNA 175
+ V GD +++SL+ + + + D+ G T HLA G+ EC +++ H V ++
Sbjct: 28 QAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDT 87
Query: 176 QGWSPLAEAISYGDRQMITALLR 198
G S L A + I LL+
Sbjct: 88 TGHSALHLAAKNSHHECIRKLLQ 110
Score = 35.4 bits (80), Expect = 0.13
Identities = 28/102 (27%), Positives = 44/102 (43%), Gaps = 3/102 (2%)
Query: 117 HECVFKGDVRRLSSLIRTHNIG--QKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKN 174
H KG V L +I TH + +D G++ LHLA + EC LL P + +
Sbjct: 61 HLAAAKGHVECLRVMI-THGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVD 119
Query: 175 AQGWSPLAEAISYGDRQMITALLRKLKQQSRESVEEKRPRLL 216
+ G + L A + G Q + L + + ++ P LL
Sbjct: 120 SSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLL 161
>gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
Length = 972
Score = 48.1 bits (113), Expect = 2e-05
Identities = 35/107 (32%), Positives = 46/107 (42%), Gaps = 5/107 (4%)
Query: 94 LLAGTNPVAVVADGGSCPAHYPVHECVFKGDVRRLSSLIRTHN-IGQKDNHGNTPLHLAV 152
LL P V G HY + G ++ + L + I KD GN PL LAV
Sbjct: 97 LLQSKCPAESVDSSGKTALHYAAAQ----GCLQAVQILCEHKSPINLKDLDGNIPLLLAV 152
Query: 153 MLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALLRK 199
G+ E H LL H A V +N G + L A G + AL++K
Sbjct: 153 QNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKK 199
Score = 40.8 bits (94), Expect = 0.003
Identities = 23/83 (27%), Positives = 40/83 (48%), Gaps = 2/83 (2%)
Query: 118 ECVFKGDVRRLSSLI--RTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNA 175
+ V GD +++SL+ + + + D+ G T HLA G+ EC +++ H V ++
Sbjct: 17 QAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDT 76
Query: 176 QGWSPLAEAISYGDRQMITALLR 198
G S L A + I LL+
Sbjct: 77 TGHSALHLAAKNSHHECIRKLLQ 99
Score = 35.4 bits (80), Expect = 0.13
Identities = 28/102 (27%), Positives = 44/102 (43%), Gaps = 3/102 (2%)
Query: 117 HECVFKGDVRRLSSLIRTHNIG--QKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKN 174
H KG V L +I TH + +D G++ LHLA + EC LL P + +
Sbjct: 50 HLAAAKGHVECLRVMI-THGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVD 108
Query: 175 AQGWSPLAEAISYGDRQMITALLRKLKQQSRESVEEKRPRLL 216
+ G + L A + G Q + L + + ++ P LL
Sbjct: 109 SSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLL 150
>gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]
Length = 951
Score = 48.1 bits (113), Expect = 2e-05
Identities = 35/107 (32%), Positives = 46/107 (42%), Gaps = 5/107 (4%)
Query: 94 LLAGTNPVAVVADGGSCPAHYPVHECVFKGDVRRLSSLIRTHN-IGQKDNHGNTPLHLAV 152
LL P V G HY + G ++ + L + I KD GN PL LAV
Sbjct: 105 LLQSKCPAESVDSSGKTALHYAAAQ----GCLQAVQILCEHKSPINLKDLDGNIPLLLAV 160
Query: 153 MLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALLRK 199
G+ E H LL H A V +N G + L A G + AL++K
Sbjct: 161 QNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKK 207
Score = 40.8 bits (94), Expect = 0.003
Identities = 23/83 (27%), Positives = 40/83 (48%), Gaps = 2/83 (2%)
Query: 118 ECVFKGDVRRLSSLI--RTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNA 175
+ V GD +++SL+ + + + D+ G T HLA G+ EC +++ H V ++
Sbjct: 25 QAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDT 84
Query: 176 QGWSPLAEAISYGDRQMITALLR 198
G S L A + I LL+
Sbjct: 85 TGHSALHLAAKNSHHECIRKLLQ 107
Score = 35.4 bits (80), Expect = 0.13
Identities = 28/102 (27%), Positives = 44/102 (43%), Gaps = 3/102 (2%)
Query: 117 HECVFKGDVRRLSSLIRTHNIG--QKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKN 174
H KG V L +I TH + +D G++ LHLA + EC LL P + +
Sbjct: 58 HLAAAKGHVECLRVMI-THGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVD 116
Query: 175 AQGWSPLAEAISYGDRQMITALLRKLKQQSRESVEEKRPRLL 216
+ G + L A + G Q + L + + ++ P LL
Sbjct: 117 SSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLL 158
>gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 48.1 bits (113), Expect = 2e-05
Identities = 35/107 (32%), Positives = 46/107 (42%), Gaps = 5/107 (4%)
Query: 94 LLAGTNPVAVVADGGSCPAHYPVHECVFKGDVRRLSSLIRTHN-IGQKDNHGNTPLHLAV 152
LL P V G HY + G ++ + L + I KD GN PL LAV
Sbjct: 105 LLQSKCPAESVDSSGKTALHYAAAQ----GCLQAVQILCEHKSPINLKDLDGNIPLLLAV 160
Query: 153 MLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALLRK 199
G+ E H LL H A V +N G + L A G + AL++K
Sbjct: 161 QNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKK 207
Score = 40.8 bits (94), Expect = 0.003
Identities = 23/83 (27%), Positives = 40/83 (48%), Gaps = 2/83 (2%)
Query: 118 ECVFKGDVRRLSSLI--RTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNA 175
+ V GD +++SL+ + + + D+ G T HLA G+ EC +++ H V ++
Sbjct: 25 QAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDT 84
Query: 176 QGWSPLAEAISYGDRQMITALLR 198
G S L A + I LL+
Sbjct: 85 TGHSALHLAAKNSHHECIRKLLQ 107
Score = 35.4 bits (80), Expect = 0.13
Identities = 28/102 (27%), Positives = 44/102 (43%), Gaps = 3/102 (2%)
Query: 117 HECVFKGDVRRLSSLIRTHNIG--QKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKN 174
H KG V L +I TH + +D G++ LHLA + EC LL P + +
Sbjct: 58 HLAAAKGHVECLRVMI-THGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVD 116
Query: 175 AQGWSPLAEAISYGDRQMITALLRKLKQQSRESVEEKRPRLL 216
+ G + L A + G Q + L + + ++ P LL
Sbjct: 117 SSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLL 158
>gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 48.1 bits (113), Expect = 2e-05
Identities = 35/107 (32%), Positives = 46/107 (42%), Gaps = 5/107 (4%)
Query: 94 LLAGTNPVAVVADGGSCPAHYPVHECVFKGDVRRLSSLIRTHN-IGQKDNHGNTPLHLAV 152
LL P V G HY + G ++ + L + I KD GN PL LAV
Sbjct: 105 LLQSKCPAESVDSSGKTALHYAAAQ----GCLQAVQILCEHKSPINLKDLDGNIPLLLAV 160
Query: 153 MLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALLRK 199
G+ E H LL H A V +N G + L A G + AL++K
Sbjct: 161 QNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKK 207
Score = 40.8 bits (94), Expect = 0.003
Identities = 23/83 (27%), Positives = 40/83 (48%), Gaps = 2/83 (2%)
Query: 118 ECVFKGDVRRLSSLI--RTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNA 175
+ V GD +++SL+ + + + D+ G T HLA G+ EC +++ H V ++
Sbjct: 25 QAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDT 84
Query: 176 QGWSPLAEAISYGDRQMITALLR 198
G S L A + I LL+
Sbjct: 85 TGHSALHLAAKNSHHECIRKLLQ 107
Score = 35.4 bits (80), Expect = 0.13
Identities = 28/102 (27%), Positives = 44/102 (43%), Gaps = 3/102 (2%)
Query: 117 HECVFKGDVRRLSSLIRTHNIG--QKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKN 174
H KG V L +I TH + +D G++ LHLA + EC LL P + +
Sbjct: 58 HLAAAKGHVECLRVMI-THGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVD 116
Query: 175 AQGWSPLAEAISYGDRQMITALLRKLKQQSRESVEEKRPRLL 216
+ G + L A + G Q + L + + ++ P LL
Sbjct: 117 SSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLL 158
>gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 48.1 bits (113), Expect = 2e-05
Identities = 35/107 (32%), Positives = 46/107 (42%), Gaps = 5/107 (4%)
Query: 94 LLAGTNPVAVVADGGSCPAHYPVHECVFKGDVRRLSSLIRTHN-IGQKDNHGNTPLHLAV 152
LL P V G HY + G ++ + L + I KD GN PL LAV
Sbjct: 105 LLQSKCPAESVDSSGKTALHYAAAQ----GCLQAVQILCEHKSPINLKDLDGNIPLLLAV 160
Query: 153 MLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALLRK 199
G+ E H LL H A V +N G + L A G + AL++K
Sbjct: 161 QNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKK 207
Score = 40.8 bits (94), Expect = 0.003
Identities = 23/83 (27%), Positives = 40/83 (48%), Gaps = 2/83 (2%)
Query: 118 ECVFKGDVRRLSSLI--RTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNA 175
+ V GD +++SL+ + + + D+ G T HLA G+ EC +++ H V ++
Sbjct: 25 QAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDT 84
Query: 176 QGWSPLAEAISYGDRQMITALLR 198
G S L A + I LL+
Sbjct: 85 TGHSALHLAAKNSHHECIRKLLQ 107
Score = 35.4 bits (80), Expect = 0.13
Identities = 28/102 (27%), Positives = 44/102 (43%), Gaps = 3/102 (2%)
Query: 117 HECVFKGDVRRLSSLIRTHNIG--QKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKN 174
H KG V L +I TH + +D G++ LHLA + EC LL P + +
Sbjct: 58 HLAAAKGHVECLRVMI-THGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVD 116
Query: 175 AQGWSPLAEAISYGDRQMITALLRKLKQQSRESVEEKRPRLL 216
+ G + L A + G Q + L + + ++ P LL
Sbjct: 117 SSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLL 158
>gi|51972284 NOTCH-regulated ankyrin repeat protein [Homo sapiens]
Length = 114
Score = 48.1 bits (113), Expect = 2e-05
Identities = 29/89 (32%), Positives = 44/89 (49%), Gaps = 5/89 (5%)
Query: 118 ECVFKGDVRRLSSLIRT-----HNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKV 172
E V KG+ + L SL++ N+ G T LH +V+ GN E LL+ A +++
Sbjct: 20 EAVRKGNTQELQSLLQNMTNCEFNVNSFGPEGQTALHQSVIDGNLELVKLLVKFGADIRL 79
Query: 173 KNAQGWSPLAEAISYGDRQMITALLRKLK 201
N GWS L A G + ++ L+ K K
Sbjct: 80 ANRDGWSALHIAAFGGHQDIVLYLITKAK 108
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 48.1 bits (113), Expect = 2e-05
Identities = 27/90 (30%), Positives = 49/90 (54%), Gaps = 1/90 (1%)
Query: 118 ECVFKGDVRRLSSLIRTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQG 177
+ + GD +L +++ ++ + G + LHLAV G +ECA LL +NA + N +G
Sbjct: 412 DAIVSGDTSKLMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRG 471
Query: 178 WSPLAEAISYGDRQMITALL-RKLKQQSRE 206
+PL A+ R ++ LL RK+ +++
Sbjct: 472 STPLHMAVERRVRGVVELLLARKISVNAKD 501
Score = 44.7 bits (104), Expect = 2e-04
Identities = 31/92 (33%), Positives = 44/92 (47%), Gaps = 3/92 (3%)
Query: 108 GSCPAHYPVHECVFKGDVRRLSSLIRTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHN 167
GS P H V V +G V L L R ++ KD T LH A G++ LLL N
Sbjct: 471 GSTPLHMAVERRV-RGVVELL--LARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKN 527
Query: 168 APVKVKNAQGWSPLAEAISYGDRQMITALLRK 199
A V + +G +P+ A +G ++ LLR+
Sbjct: 528 ASVNEVDFEGRTPMHVACQHGQENIVRILLRR 559
Score = 40.4 bits (93), Expect = 0.004
Identities = 25/83 (30%), Positives = 34/83 (40%)
Query: 131 LIRTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDR 190
L+ N + G+TPLH+AV + LLLA V K+ W+ L A GD
Sbjct: 458 LLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDE 517
Query: 191 QMITALLRKLKQQSRESVEEKRP 213
LL K + E + P
Sbjct: 518 SSTRLLLEKNASVNEVDFEGRTP 540
Score = 38.5 bits (88), Expect = 0.016
Identities = 41/179 (22%), Positives = 65/179 (36%), Gaps = 12/179 (6%)
Query: 22 LLEPGDEEAAAALGGTFTRSRIGKGGKACHKIFSNHHHRLQLKAAPASSNPPGAPALPLH 81
+L+P D + A G + + G + C K L A P SN G+ PLH
Sbjct: 425 ILQPQDVDLALDSGASLLHLAVEAGQEECAKWL------LLNNANPNLSNRRGST--PLH 476
Query: 82 NSSVTANSQSPALLAGTNPVAVVADGGSCPAHYPVHECVFKGDVRRLSSLIRTH-NIGQK 140
+ LL D A +H GD L+ + ++ +
Sbjct: 477 MAVERRVRGVVELLLARKISVNAKDEDQWTA---LHFAAQNGDESSTRLLLEKNASVNEV 533
Query: 141 DNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITALLRK 199
D G TP+H+A G + +LL V ++ W PL A G ++ L ++
Sbjct: 534 DFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQ 592
Score = 32.0 bits (71), Expect = 1.5
Identities = 32/123 (26%), Positives = 50/123 (40%), Gaps = 3/123 (2%)
Query: 78 LPLHNSSVTANSQSPALLAGTNPVAVVADGGSCPAHYPVHECVFKGDVRRLSSLIRT-HN 136
LPLH ++ + LLA V+V A + P+H +G R LI +
Sbjct: 572 LPLHYAAWQGHLPIVKLLAKQPGVSVNAQ--TLDGRTPLHLAAQRGHYRVARILIDLCSD 629
Query: 137 IGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMITAL 196
+ TPLH+A G+ A LLL A + + G++ L A G + L
Sbjct: 630 VNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLL 689
Query: 197 LRK 199
+ +
Sbjct: 690 VEE 692
Score = 31.2 bits (69), Expect = 2.5
Identities = 23/90 (25%), Positives = 39/90 (43%), Gaps = 2/90 (2%)
Query: 112 AHYPVHECVFKGDVRRLSSLIRTH--NIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAP 169
A P+H ++G + + L + ++ + G TPLHLA G+ A +L+ +
Sbjct: 570 AWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSD 629
Query: 170 VKVKNAQGWSPLAEAISYGDRQMITALLRK 199
V V + +PL A G LL +
Sbjct: 630 VNVCSLLAQTPLHVAAETGHTSTARLLLHR 659
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,696,021
Number of Sequences: 37866
Number of extensions: 1020556
Number of successful extensions: 5201
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 289
Number of HSP's successfully gapped in prelim test: 52
Number of HSP's that attempted gapping in prelim test: 3762
Number of HSP's gapped (non-prelim): 1300
length of query: 541
length of database: 18,247,518
effective HSP length: 107
effective length of query: 434
effective length of database: 14,195,856
effective search space: 6161001504
effective search space used: 6161001504
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.