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Search of human proteins with 166362728
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|166362728 epidermal growth factor (beta-urogastrone) [Homo
sapiens]
(1207 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|166362728 epidermal growth factor (beta-urogastrone) [Homo sa... 2551 0.0
gi|157384998 low density lipoprotein receptor-related protein 4 ... 293 7e-79
gi|126012562 low density lipoprotein-related protein 1 [Homo sap... 271 3e-72
gi|119709832 low density lipoprotein receptor-related protein 5 ... 250 7e-66
gi|61744471 low density lipoprotein receptor-related protein 8 i... 240 5e-63
gi|61744467 low density lipoprotein receptor-related protein 8 i... 240 5e-63
gi|65301119 low density lipoprotein receptor-related protein 8 i... 240 5e-63
gi|148727288 low density lipoprotein receptor-related protein 6 ... 239 1e-62
gi|66082554 low density lipoprotein receptor-related protein 8 i... 239 1e-62
gi|126012573 low density lipoprotein-related protein 2 [Homo sap... 234 5e-61
gi|4504975 low density lipoprotein receptor precursor [Homo sapi... 229 2e-59
gi|93102379 low density lipoprotein-related protein 1B precursor... 227 6e-59
gi|65301164 very low density lipoprotein receptor isoform b [Hom... 217 6e-56
gi|65301167 very low density lipoprotein receptor isoform a [Hom... 217 6e-56
gi|115298674 nidogen 1 precursor [Homo sapiens] 164 5e-40
gi|144953895 nidogen 2 precursor [Homo sapiens] 145 2e-34
gi|32698824 low density lipoprotein receptor-related protein 5-l... 135 2e-31
gi|209447022 low density lipoprotein receptor-related protein 5-... 135 2e-31
gi|4507157 sortilin-related receptor containing LDLR class A rep... 123 9e-28
gi|66346695 fibrillin 2 precursor [Homo sapiens] 122 2e-27
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens] 121 4e-27
gi|62548862 matrilin 2 isoform b precursor [Homo sapiens] 121 5e-27
gi|62548860 matrilin 2 isoform a precursor [Homo sapiens] 121 5e-27
gi|24430141 fibrillin 1 precursor [Homo sapiens] 120 6e-27
gi|11321565 matrilin 3 precursor [Homo sapiens] 115 2e-25
gi|56237021 fibrillin 3 precursor [Homo sapiens] 108 2e-23
gi|10190748 CEGP1 protein [Homo sapiens] 104 4e-22
gi|13699830 matrilin 4 isoform 1 precursor [Homo sapiens] 104 4e-22
gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens] 101 5e-21
gi|118572606 hemicentin 1 [Homo sapiens] 99 2e-20
>gi|166362728 epidermal growth factor (beta-urogastrone) [Homo
sapiens]
Length = 1207
Score = 2551 bits (6613), Expect = 0.0
Identities = 1207/1207 (100%), Positives = 1207/1207 (100%)
Query: 1 MLLTLIILLPVVSKFSFVSLSAPQHWSCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRID 60
MLLTLIILLPVVSKFSFVSLSAPQHWSCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRID
Sbjct: 1 MLLTLIILLPVVSKFSFVSLSAPQHWSCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRID 60
Query: 61 TEGTNYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSG 120
TEGTNYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSG
Sbjct: 61 TEGTNYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSG 120
Query: 121 MAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAG 180
MAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAG
Sbjct: 121 MAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAG 180
Query: 181 SLYRADLDGVGVKALLETSEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHI 240
SLYRADLDGVGVKALLETSEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHI
Sbjct: 181 SLYRADLDGVGVKALLETSEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHI 240
Query: 241 SKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHP 300
SKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHP
Sbjct: 241 SKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHP 300
Query: 301 LAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNEC 360
LAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNEC
Sbjct: 301 LAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNEC 360
Query: 361 AFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPL 420
AFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPL
Sbjct: 361 AFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPL 420
Query: 421 CFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASG 480
CFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASG
Sbjct: 421 CFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASG 480
Query: 481 PQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERAN 540
PQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERAN
Sbjct: 481 PQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERAN 540
Query: 541 MDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQP 600
MDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQP
Sbjct: 541 MDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQP 600
Query: 601 RGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCD 660
RGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCD
Sbjct: 601 RGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCD 660
Query: 661 AKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVR 720
AKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVR
Sbjct: 661 AKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVR 720
Query: 721 LQGSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTC 780
LQGSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTC
Sbjct: 721 LQGSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTC 780
Query: 781 LALDGHQLLAGGEVDLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGC 840
LALDGHQLLAGGEVDLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGC
Sbjct: 781 LALDGHQLLAGGEVDLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGC 840
Query: 841 SMYARCISEGEDATCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCS 900
SMYARCISEGEDATCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCS
Sbjct: 841 SMYARCISEGEDATCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCS 900
Query: 901 EGYQGDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHL 960
EGYQGDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHL
Sbjct: 901 EGYQGDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHL 960
Query: 961 REDDHHYSVRNSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLKWW 1020
REDDHHYSVRNSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLKWW
Sbjct: 961 REDDHHYSVRNSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLKWW 1020
Query: 1021 ELRHAGHGQQQKVIVVAVCVVVLVMLLLLSLWGAHYYRTQKLLSKNPKNPYEESSRDVRS 1080
ELRHAGHGQQQKVIVVAVCVVVLVMLLLLSLWGAHYYRTQKLLSKNPKNPYEESSRDVRS
Sbjct: 1021 ELRHAGHGQQQKVIVVAVCVVVLVMLLLLSLWGAHYYRTQKLLSKNPKNPYEESSRDVRS 1080
Query: 1081 RRPADTEDGMSSCPQPWFVVIKEHQDLKNGGQPVAGEDGQAADGSMQPTSWRQEPQLCGM 1140
RRPADTEDGMSSCPQPWFVVIKEHQDLKNGGQPVAGEDGQAADGSMQPTSWRQEPQLCGM
Sbjct: 1081 RRPADTEDGMSSCPQPWFVVIKEHQDLKNGGQPVAGEDGQAADGSMQPTSWRQEPQLCGM 1140
Query: 1141 GTEQGCWIPVSSDKGSCPQVMERSFHMPSYGTQTLEGGVEKPHSLLSANPLWQQRALDPP 1200
GTEQGCWIPVSSDKGSCPQVMERSFHMPSYGTQTLEGGVEKPHSLLSANPLWQQRALDPP
Sbjct: 1141 GTEQGCWIPVSSDKGSCPQVMERSFHMPSYGTQTLEGGVEKPHSLLSANPLWQQRALDPP 1200
Query: 1201 HQMELTQ 1207
HQMELTQ
Sbjct: 1201 HQMELTQ 1207
>gi|157384998 low density lipoprotein receptor-related protein 4
[Homo sapiens]
Length = 1905
Score = 293 bits (750), Expect = 7e-79
Identities = 162/428 (37%), Positives = 235/428 (54%), Gaps = 14/428 (3%)
Query: 400 SCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSS-PDNGGCSQLCVPLSPVS 458
+C N C+ C + C C G L DG TC + + G CSQ C S +
Sbjct: 357 NCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTN-SEGA 415
Query: 459 WECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALD 518
++C C GY+L+ D +SC A GP+P LLFAN DIR + ++Y TLL + ALD
Sbjct: 416 FQCWCETGYELRPDRRSCKALGPEPVLLFANRIDIRQVLPHRSEY-TLLLNNLENAIALD 474
Query: 519 HDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSL 578
++++ L I RAN++GS E ++ G++ P GLAVDW+ + YWTD G S
Sbjct: 475 FHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSR 534
Query: 579 IGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIAS 638
I ++L+G K++ +N+ +PR IA+HPM ++WTD G PRIE+SS+ G GR +IA
Sbjct: 535 IEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIAD 594
Query: 639 SDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVW 698
+ L WP+G+TID+ ++YW DAK VIE ANLDGS R+ + + HPFA+ VFED ++
Sbjct: 595 THLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLY 654
Query: 699 FSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAKP-GADPCLYQNGGCEHICK 757
++DW S+ NK TGK++ ++ + P + +HP +P G + C NGGC H+C
Sbjct: 655 WTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCL 714
Query: 758 KRLGTAWCSCREGFMKASDGKTCLALDGHQLLAG---------GEVDLKNQVTPL-DILS 807
C+C GF K S +LD L A DL + V PL D+ S
Sbjct: 715 PSGQNYTCACPTGFRKISSHACAQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADVRS 774
Query: 808 KTRVSEDN 815
+ D+
Sbjct: 775 AVALDWDS 782
Score = 246 bits (627), Expect = 1e-64
Identities = 192/762 (25%), Positives = 320/762 (41%), Gaps = 144/762 (18%)
Query: 27 SCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRI--DTEGTNYEQL-VVDAGVSVIMDFHY 83
+CP G + ++ FL+F+ I RI DTE + + + + D +V +D+
Sbjct: 723 ACPTGFRKISSHACAQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSAVALDWDS 782
Query: 84 NEKRIYWVDLERQLLQRVFLNGSRQERVCNIE-KNVSGMAINWINEEVIWSNQQEGIITV 142
+ +YW D+ + R +G+ QE V + ++ +G+AI+W+ ++ W++ I V
Sbjct: 783 RDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEV 842
Query: 143 TDMKGNNSHILL-SALKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALLETSEK 201
+ G+ +L+ L P ++ V+P+ +++W+ A S K
Sbjct: 843 ANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGA-------------------SPK 883
Query: 202 ITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFY 261
I +D G V IS + T N A+ R+++
Sbjct: 884 IERAGMDA------------------------SGRQVIISSNLTWPNGLAIDYGSQRLYW 919
Query: 262 STWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLR 321
+ MKTI A K V I ++ HP + + + + ++
Sbjct: 920 ADAGMKTIEFAGLDGSKRKVLIGS----------QLPHPFGLTLYGERIYWTDWQTKSIQ 969
Query: 322 KGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCT 381
+ + + + LQ +L + + R R CA N GC+ C +P
Sbjct: 970 SADRLTGLDRETLQENLENLMDIHVFHRRRPPVS--TPCAMENGGCSHLCLRSPN----- 1022
Query: 382 CPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSS 441
P GF C CP G L DGKTCS
Sbjct: 1023 -PSGFS---------------------------------CTCPTGINLLSDGKTCS---- 1044
Query: 442 PDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFD-- 499
G FL+FA DIR + D
Sbjct: 1045 -------------------------------------PGMNSFLIFARRIDIRMVSLDIP 1067
Query: 500 -GTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPE 558
D ++ M A+ DP E K+Y++ + L I RAN+DGSQ E +I G+ +
Sbjct: 1068 YFADVVVPINITMKNTIAIGVDPQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTD 1127
Query: 559 GLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTG 618
GLAVD IGR+ YWTD G + I +L+G K++ +N+ PR I ++ ++WTD G
Sbjct: 1128 GLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWG 1187
Query: 619 INPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRR 678
N ++E S + G R V+ +++L WP+G+T+D + +L W DA IE A+L+G+ R
Sbjct: 1188 ENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHT 1247
Query: 679 LTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVVVHPLA 738
L + V HP+ + + + Y++++DW S+ R +K TG + + ++ ++ + V
Sbjct: 1248 LV-SPVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAVDRAQ 1306
Query: 739 KPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTC 780
G + C +NGGC H+C R C+C G DGKTC
Sbjct: 1307 PLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTC 1348
Score = 244 bits (623), Expect = 4e-64
Identities = 129/384 (33%), Positives = 208/384 (54%), Gaps = 17/384 (4%)
Query: 443 DNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTD 502
+NGGC+ LC+P S ++ C C G+ ++ +CA S + FLLFA DIR + FD D
Sbjct: 705 NNGGCTHLCLP-SGQNYTCACPTGFR-KISSHACAQSLDK-FLLFARRMDIRRISFDTED 761
Query: 503 YG--TLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGL 560
+ + ALD D ++ +Y+ + I RA DG+ +E +++ ++ P GL
Sbjct: 762 LSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGL 821
Query: 561 AVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGIN 620
A+DW+ + YWTD G I ++ +G ++ EN+ +PR I V PM ++WTD G +
Sbjct: 822 AIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGAS 881
Query: 621 PRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLT 680
P+IE + + GR VI SS+L WP+G+ ID+ + +LYW DA IE A LDGSKR+ L
Sbjct: 882 PKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLI 941
Query: 681 QNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAKP 740
+ + HPF + ++ + ++++DW S+ ++ TG DR LQ ++ + V H P
Sbjct: 942 GSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPP 1001
Query: 741 GADPCLYQNGGCEHICKKRLGTAW--CSCREGFMKASDGKTCLALDGHQLLAGGEVDLK- 797
+ PC +NGGC H+C + + C+C G SDGKTC L+ +D++
Sbjct: 1002 VSTPCAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTCSPGMNSFLIFARRIDIRM 1061
Query: 798 ---------NQVTPLDILSKTRVS 812
+ V P++I K ++
Sbjct: 1062 VSLDIPYFADVVVPINITMKNTIA 1085
Score = 239 bits (610), Expect = 1e-62
Identities = 124/344 (36%), Positives = 200/344 (58%), Gaps = 9/344 (2%)
Query: 444 NGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDY 503
NGGCS LC+P P + C C G L+ D K+C S P+ +LLF++ IR + D +D+
Sbjct: 1317 NGGCSHLCLP-RPSGFSCACPTGIQLKGDGKTCDPS-PETYLLFSSRGSIRRISLDTSDH 1374
Query: 504 GTLLSQ--QMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLA 561
+ ++ V +LD+D V+ K+Y+ L I RA+++GS E +I G+ +GLA
Sbjct: 1375 TDVHVPVPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLA 1434
Query: 562 VDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINP 621
VDW+ R YWTD G++ I S L+G K++ ++ +PR IAV P LFWTD G
Sbjct: 1435 VDWVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIA 1494
Query: 622 RIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQ 681
+IE ++L G R V+ ++DL WP+G+T+D+ T ++YW DA IE A+L+G K R++
Sbjct: 1495 KIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNG-KLRQVLV 1553
Query: 682 NDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAKPG 741
+ V HPFA+ + +++++DW S+ RV+K +G+++ + ++ ++VV P + G
Sbjct: 1554 SHVSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQTG 1613
Query: 742 ADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDG 785
+ C NGGC H+C R C+C + D + C + G
Sbjct: 1614 TNACGVNNGGCTHLCFARASDFVCACPD----EPDSRPCSLVPG 1653
Score = 111 bits (277), Expect = 5e-24
Identities = 74/310 (23%), Positives = 154/310 (49%), Gaps = 23/310 (7%)
Query: 42 VGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRV 101
+GP P L+F++ I ++ + Y L+ + ++ +DFH+ + ++W D+ + R
Sbjct: 436 LGPEPVLLFANRIDIRQVLPHRSEYTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRA 495
Query: 102 FLNGSRQERVCNIE-KNVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILL-SALKY 159
LNGS E V + ++ G+A++W+++++ W++ I V ++ G + +LL L+
Sbjct: 496 NLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEK 555
Query: 160 PANVAVDPVERFIFWSS-EVAGSLYRADLDGVGVKALLETS-EKITAVSLDVLDKRLFWI 217
P +A+ P+E I+W+ + + +DG G + + +T +++D +R++W+
Sbjct: 556 PRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWV 615
Query: 218 QYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTG 277
+ + +I + DG + FA+++F D ++++ W K+I ANK TG
Sbjct: 616 ----DAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTG 671
Query: 278 K--DMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQ 335
K +++R LH ++ +HP QP ++ C G C+ +C Q
Sbjct: 672 KNQEIIRNKLHFPM----DIHTLHPQRQPAGKN--------RCGDNNGGCTH-LCLPSGQ 718
Query: 336 SHLCMCAEGY 345
++ C C G+
Sbjct: 719 NYTCACPTGF 728
Score = 93.2 bits (230), Expect = 1e-18
Identities = 83/340 (24%), Positives = 157/340 (46%), Gaps = 31/340 (9%)
Query: 16 SFVSLSAPQHWSC--PEGT-LAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYEQL--- 69
S + L P +SC P G L G+G + P +L+FS SI RI + +++ +
Sbjct: 1321 SHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLDTSDHTDVHVP 1380
Query: 70 VVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIE-KNVSGMAINWINE 128
V + + +D+ + ++Y+ D+ +++R LNGS E V K G+A++W+
Sbjct: 1381 VPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVAR 1440
Query: 129 EVIWSNQQEGIITVTDMKGNNSHILL-SALKYPANVAVDPVERFIFWSS-EVAGSLYRAD 186
+ W++ I + + G+ +L+ ++L P +AV P + ++FW+ + RA+
Sbjct: 1441 NLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERAN 1500
Query: 187 LDGVGVKALLETS-EKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPT 245
LDG K L+ T ++LD +R++W+ + + I S D +G +
Sbjct: 1501 LDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLD----RIESADLNGKLRQVLVSHV 1556
Query: 246 QHNLFAMSLFGDRIFYSTWKMKTIWIANKHTG--KDMVRINLHSSFVPLGELKVVHPLAQ 303
H FA++ I+++ W+ K+I +K++G K+ V N+ L ++ VV P Q
Sbjct: 1557 SHP-FALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEG----LMDIIVVSPQRQ 1611
Query: 304 PKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAE 343
C + G C+ +C +C C +
Sbjct: 1612 TGT---------NACGVNNGGCTH-LCFARASDFVCACPD 1641
Score = 82.0 bits (201), Expect = 3e-15
Identities = 78/338 (23%), Positives = 147/338 (43%), Gaps = 26/338 (7%)
Query: 27 SCPEG-TLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGVS----VIMDF 81
+CP G L +G + G FLIF+ I + + + +VV ++ + +
Sbjct: 1029 TCPTGINLLSDGKTCSPGMNSFLIFARRIDIRMVSLDIPYFADVVVPINITMKNTIAIGV 1088
Query: 82 HYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIE-KNVSGMAINWINEEVIWSNQQEGII 140
E ++YW D + R L+GS+ E + + G+A++ I +V W++ I
Sbjct: 1089 DPQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRI 1148
Query: 141 TVTDMKGNNSHILL-SALKYPANVAVDPVERFIFWSSEVAGS-LYRADLDGVGVKALLET 198
V ++ G+ +L+ L P + + F++W+ + L R+ +DG L+
Sbjct: 1149 EVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLINN 1208
Query: 199 SEKI-TAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGD 257
+ +++D +L W + E I + D +G + H P QH + ++L
Sbjct: 1209 NLGWPNGLTVDKASSQLLWADAHTER----IEAADLNGANRHTLVSPVQHP-YGLTLLDS 1263
Query: 258 RIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKL 317
I+++ W+ ++I A+K TG +++ + S+ L +++ V AQP +
Sbjct: 1264 YIYWTDWQTRSIHRADKGTGSNVILV--RSNLPGLMDMQAV-DRAQPLGFNK-------- 1312
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCE 355
C R G CS +C C C G L D K C+
Sbjct: 1313 CGSRNGGCSH-LCLPRPSGFSCACPTGIQLKGDGKTCD 1349
Score = 65.5 bits (158), Expect = 3e-10
Identities = 36/99 (36%), Positives = 52/99 (52%), Gaps = 9/99 (9%)
Query: 308 DDTWEPEQKLCKLRKG----NCSSTVCGQDLQ----SHLCMCAEGYALSRDRKYCEDVNE 359
D++ E Q+ C+ R G N ++ C Q Q + C C GY L+ D C+DVNE
Sbjct: 339 DNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNE 398
Query: 360 CAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQL 398
CA + C+ GC N+ G++ C C G+ L PD + C L
Sbjct: 399 CAEEGY-CSQGCTNSEGAFQCWCETGYELRPDRRSCKAL 436
Score = 45.8 bits (107), Expect = 2e-04
Identities = 30/98 (30%), Positives = 41/98 (41%), Gaps = 23/98 (23%)
Query: 863 GDGKLCSDIDEC-----EMGVPVCPP-------------ASSKCINTEGGYVCRCSEGYQ 904
G KLC+ +++C E C P + KC G C C GY+
Sbjct: 326 GQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYR 385
Query: 905 --GDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMC 940
DG C D++EC E C + CTN+EG + C C
Sbjct: 386 LTEDGHTCQDVNECA-EEGYCSQG--CTNSEGAFQCWC 420
Score = 41.6 bits (96), Expect = 0.005
Identities = 21/67 (31%), Positives = 29/67 (43%), Gaps = 6/67 (8%)
Query: 839 GCSMYARCISEGEDATCQCLKGFAGDGKLCSDIDEC-EMGVPVCPPASSKCINTEGGYVC 897
GC+ + + TC DG C D++EC E G S C N+EG + C
Sbjct: 364 GCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGY-----CSQGCTNSEGAFQC 418
Query: 898 RCSEGYQ 904
C GY+
Sbjct: 419 WCETGYE 425
Score = 39.7 bits (91), Expect = 0.018
Identities = 15/42 (35%), Positives = 20/42 (47%)
Query: 739 KPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTC 780
+ G + C NGGC C+ G C+C G+ DG TC
Sbjct: 352 RTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTC 393
>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
Length = 4544
Score = 271 bits (693), Expect = 3e-72
Identities = 194/629 (30%), Positives = 279/629 (44%), Gaps = 99/629 (15%)
Query: 341 CAEGYALSRDRKYCEDVNEC------AFWNHGCTLGCKNTPGSYYCTCPVGFVLLP---- 390
CA G LS + C+ N+C A N CT S C G +
Sbjct: 2865 CANGRCLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLC 2924
Query: 391 ----------DGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSG-- 438
D + CH R +S CS DC G C C G L+ DG+TC+
Sbjct: 2925 NGQDDCGDSSDERGCHINECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVD 2984
Query: 439 -CSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQL-DEKSC-AASGPQPFLLFANSQDIRH 495
CS+ CSQ C+ S++C C GY + D SC A + +PFL+FAN +R
Sbjct: 2985 ECST--TFPCSQRCINTHG-SYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRK 3041
Query: 496 MHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALK--WIERANMDGSQRERLIEEG 553
++ DG++Y TLL Q + ALD D E IY+ + I R +++GS + L G
Sbjct: 3042 LNLDGSNY-TLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTG 3100
Query: 554 VDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLF 613
+ P+GLAVDW+G YW D+G+ I S LNG ++ + +PR + V L+
Sbjct: 3101 LSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLY 3160
Query: 614 WTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDG 673
WTD G + I + G R VI + + WP+G+T+D++T+++YW DA++ IE A+LDG
Sbjct: 3161 WTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDG 3220
Query: 674 SKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVV 733
S R + D+ H FA+ +FEDYV+++DW S+ R +K TG ++ L ++ +P L V
Sbjct: 3221 SNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHV 3280
Query: 734 VHPLAKPGA--DPCLYQNGGCEHICKKRLGTAW-CSCREGFMKASDGKTCLALDGHQLLA 790
H L +P PC NGGC ++C G C+C F SDG+TC++
Sbjct: 3281 FHALRQPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTCVS-------- 3332
Query: 791 GGEVDLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMV------SDQDDCA-----PVG 839
N T SQ + + + +DDC P
Sbjct: 3333 ------------------------NCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPD 3368
Query: 840 CSMYARCISEGEDATCQCLKGFA--------GDGKLCSDIDECEMGVPVCPPASSKCINT 891
C + +C QC G GD + DE + VC P+ KC NT
Sbjct: 3369 CPEF-KC----RPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNT 3423
Query: 892 EGGYVCRCSEGYQGDGIHCLDIDECQLGE 920
RC G C D C GE
Sbjct: 3424 N-----RCIPGI----FRCNGQDNCGDGE 3443
Score = 216 bits (551), Expect = 8e-56
Identities = 129/367 (35%), Positives = 195/367 (53%), Gaps = 11/367 (2%)
Query: 429 LERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFA 488
++ D K + CS +NG CSQLC+P S + C C GY L+ +++C G FLL++
Sbjct: 1840 IQLDHKGTNPCSV-NNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGS--FLLYS 1896
Query: 489 NSQDIRHMHFDGTDYGTLLSQQMG--MVYALDHDPVENKIYFAHTALKWIERANMDGSQR 546
+ IR + D D L G + +D + IY+ L I RA D + R
Sbjct: 1897 VHEGIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWR 1956
Query: 547 ERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVH 606
E ++ G+ EG+AVDWI YWTD+G +I + LNG ++ + + +PR I VH
Sbjct: 1957 EDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVH 2016
Query: 607 PMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVI 666
P LFWT+ G PRIE S L G R+V+ + + WP+GI++D+ KLYWCDA+ I
Sbjct: 2017 PEKGYLFWTEWGQYPRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKI 2076
Query: 667 EMANLD-GSKRRRLTQNDVGHPFAVAVFEDYVWFSD--WAMPSVMRVNKRTGKDRVRLQ- 722
E +L+ G R + ++ F+V+VFED++++SD A S+ R +K D V L+
Sbjct: 2077 ERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRT 2136
Query: 723 GSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHICKKR-LGTAWCSCREGFMKASDGKTCL 781
G ++ + V + + G + C NGGC+ +C R G C+C G M A DG +C
Sbjct: 2137 GIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRGRGQRACACAHG-MLAEDGASCR 2195
Query: 782 ALDGHQL 788
G+ L
Sbjct: 2196 EYAGYLL 2202
Score = 198 bits (503), Expect = 3e-50
Identities = 145/461 (31%), Positives = 217/461 (47%), Gaps = 47/461 (10%)
Query: 354 CEDVNECAFWNHGC-TLGCKNTPGSYYCTCPVGFVLLPD---------------GKRCHQ 397
CED ++ C +L C+ P S+ C L PD G+ C Q
Sbjct: 1131 CEDNSD----EENCESLACR--PPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQ 1184
Query: 398 LVSCPRNVSECSHDC-VLTSEGPLCFCPEGSVLERDGKTC---SGCSSPDNGGCSQLCVP 453
C N CSH+C V EG +C CP G L D TC S C+ + CSQ C
Sbjct: 1185 ---CSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAK--HLKCSQKC-D 1238
Query: 454 LSPVSWECDCFPGYDLQLDEKSCAASGP-QPFLLFANSQDIRHMHFDGTDYGTLLSQQMG 512
+ S +C C+ G+ L+ D +SC + P +PF++F+N +IR + DY L+
Sbjct: 1239 QNKFSVKCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRN 1298
Query: 513 MVYALDHDPVENKIYFAHTALKWIERANM--DGSQR--ERLIEEGVDVPEGLAVDWIGRR 568
+ ALD ++ +Y+ I R + +G+ E +I+ G+ PEGLAVDWI
Sbjct: 1299 TI-ALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGN 1357
Query: 569 FYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGIN-PRIESSS 627
YW + I + L+G + +I PR IA+ P LFWTD + PRIE++S
Sbjct: 1358 IYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAAS 1417
Query: 628 LQGLGRLVI--ASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQND-- 683
+ G GR + + WP+G+T+D+L ++ W DA+ I A DGS + +
Sbjct: 1418 MSGAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEF 1477
Query: 684 VGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAKPGAD 743
+ HPFAV ++ V+++DW ++ + NK TG + +Q + +P L V HP +P A
Sbjct: 1478 LSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAP 1537
Query: 744 PCLYQNGG---CEHICKKRLG-TAWCSCREGFMKASDGKTC 780
NGG C H+C T C+C D TC
Sbjct: 1538 NPCEANGGQGPCSHLCLINYNRTVSCACPHLMKLHKDNTTC 1578
Score = 176 bits (447), Expect = 9e-44
Identities = 127/422 (30%), Positives = 189/422 (44%), Gaps = 38/422 (9%)
Query: 391 DGKRCHQLV-SCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSG---CSSPDNGG 446
+G C +L +C R C H CV T +GP C+C L+ DGKTC CS G
Sbjct: 104 EGPHCRELQGNCSR--LGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSV--YGT 159
Query: 447 CSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQ----PFLLFANSQDIRHMHFDGTD 502
CSQLC S+ C C GY LQ D +SC A P LL ANSQ+I + G
Sbjct: 160 CSQLCTNTDG-SFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQ 218
Query: 503 YGTLLSQQMGMVYALDHDPVENKIYFAH-------TALKWIERANMDGSQRERLIEEGVD 555
T+ A+D + + H T LK + G E I +
Sbjct: 219 VSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINISLS 278
Query: 556 VP--EGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLF 613
+ E +A+DW+ FY+ D I + NG + + P+GIA+ P ++F
Sbjct: 279 LHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVF 338
Query: 614 WTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDG 673
+TD G P++E + G R + S +++P GIT+D ++ +YW DA IE+ + +G
Sbjct: 339 FTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEG 398
Query: 674 SKRRRLTQND-VGHPFAVAVFEDYVWFSD------WAMPSVMRVNKRTGKDRVRLQGSML 726
R+ + Q + H + + VFE+Y++ ++ SV+RVN R ++ +
Sbjct: 399 KGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVN-RFNSTEYQVVTRVD 457
Query: 727 KPSSLVVVHPLAKPGADPCLYQN------GGCEHIC--KKRLGTAWCSCREGFMKASDGK 778
K +L + H +P +N GGC IC C CR GF SDGK
Sbjct: 458 KGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGK 517
Query: 779 TC 780
+C
Sbjct: 518 SC 519
Score = 171 bits (434), Expect = 3e-42
Identities = 171/737 (23%), Positives = 289/737 (39%), Gaps = 140/737 (18%)
Query: 397 QLVSCPRNVSECSHD--CVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDN-GGCSQLCVP 453
+L SC N S C + CV T + C C G C + G CSQLC
Sbjct: 3781 KLTSCATNASICGDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQLCNN 3840
Query: 454 LSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLF-ANSQDIRHMHFDGTDYGTLLSQQMG 512
C C + +C A G + +L+ A+ +IR + F G + G
Sbjct: 3841 TKG-GHLCSCARNF--MKTHNTCKAEGSEYQVLYIADDNEIRSL-FPGHPHSAYEQAFQG 3896
Query: 513 ----MVYALDHDPVENKIYFAHTALKWIERANMD-------GSQRERLIEEGVD------ 555
+ A+D ++Y+ + I ++ ++ R I+ GV
Sbjct: 3897 DESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISG 3956
Query: 556 --VPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLF 613
+P G+A+DW+ YWTD G+ +I + + G+ K + I +P I V P+ ++
Sbjct: 3957 LKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMY 4016
Query: 614 WTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDG 673
W+D G +P+IE++++ G R + ++ WP+G+ +D+ ++LYW DAK SVI L+G
Sbjct: 4017 WSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNG 4076
Query: 674 SKR--RRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSL 731
+ ++ + HPF++ VFEDY++ + V +++K V L G + S +
Sbjct: 4077 TDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDV 4136
Query: 732 VVVHPLAKPG-ADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGH---- 786
V+ H +P +PC CE +C C+C G K D TC+ +
Sbjct: 4137 VLYHQHKQPEVTNPC--DRKKCEWLCLLSPSGPVCTCPNG--KRLDNGTCVPVPSPTPPP 4192
Query: 787 ----------QLLAGGEVDLKNQVTPLDILSKTRVSEDNITESQ------HMLVAEIMVS 830
Q GG L + P + R + D Q + S
Sbjct: 4193 DAPRPGTCNLQCFNGGSCFLNARRQP-KCRCQPRYTGDKCELDQCWEHCRNGGTCAASPS 4251
Query: 831 DQDDC-APVG--------------CSMYARC-ISEGEDATCQCLKGFAGD-------GKL 867
C P G C+ + C +++G C+CL GF GD
Sbjct: 4252 GMPTCRCPTGFTGPKCTQQVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGY 4311
Query: 868 CSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCLDIDECQLGEHSCGENA 927
C + C+M +G CRC+ ++G C ++++C C E A
Sbjct: 4312 CENFGTCQMA-------------ADGSRQCRCTAYFEGS--RC-EVNKCS----RCLEGA 4351
Query: 928 SCTNTEGG-YTCMCA-GRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCL 985
N + G TC C GR++ L C G+C
Sbjct: 4352 CVVNKQSGDVTCNCTDGRVAPSCLTCV-----------------------------GHCS 4382
Query: 986 HDGVCMYIEALDKYACNCVVGYIGERCQYRDLKWWELRHAGHGQQQKVIVVAVCVVVLVM 1045
+ G C + + C C G RC+ H QQQ + ++ + +L++
Sbjct: 4383 NGGSCT-MNSKMMPECQCPPHMTGPRCE---------EHV-FSQQQPGHIASILIPLLLL 4431
Query: 1046 LLLLSLWGAHYYRTQKL 1062
LLL+ + G ++ +++
Sbjct: 4432 LLLVLVAGVVFWYKRRV 4448
Score = 158 bits (399), Expect = 3e-38
Identities = 105/358 (29%), Positives = 176/358 (49%), Gaps = 20/358 (5%)
Query: 445 GGCSQLCVPL-SPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQD--IRHMHFDGT 501
GGCS +C+ S + C C G+ L D KSC + FL++ + IR M
Sbjct: 487 GGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAK 546
Query: 502 --DYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEG 559
D + + + ALD IYFA T I R +DG++RE ++++G+ EG
Sbjct: 547 VPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEG 606
Query: 560 LAVDWIGRRFYWTDRGKS---LIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTD 616
+AVDW+G YWTD G + R + + K + + ++ PR I V P+ ++WTD
Sbjct: 607 VAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTD 666
Query: 617 TGINP------RIESSSLQGLGR-LVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMA 669
+P R+E + + G R + + S ++WP+G+++D +LYW DA IE
Sbjct: 667 WEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETI 726
Query: 670 NLDGSKRRRLTQN-DVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTG--KDRVRLQGSML 726
L+G+ R+ + + ++ H F + +Y++++++ SV R+ + G V L S
Sbjct: 727 LLNGTDRKIVYEGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSER 786
Query: 727 KPSSLVVVHPLAKP--GADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLA 782
P + ++ + G + C NGGC +C G+ C+C E + +DG TCLA
Sbjct: 787 PPIFEIRMYDAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLA 844
Score = 144 bits (364), Expect = 4e-34
Identities = 100/352 (28%), Positives = 161/352 (45%), Gaps = 28/352 (7%)
Query: 445 GGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDYG 504
G CS LC+ + C C L D +C + FLL+A +IR + D Y
Sbjct: 1547 GPCSHLCLINYNRTVSCACPHLMKLHKDNTTCYEF--KKFLLYARQMEIRGVDLDAPYYN 1604
Query: 505 TLLS---QQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLA 561
++S + V LD+D E ++Y++ + I+RA ++G+ E ++ + GLA
Sbjct: 1605 YIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLA 1664
Query: 562 VDWIGRRFYWT--DRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGI 619
VDW+ R +WT D K I + L+G + + + QP G+ VHP+ +L+WTD
Sbjct: 1665 VDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVV-QGLEQPHGLVVHPLRGKLYWTD--- 1720
Query: 620 NPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRL 679
I +++ G R ++ S P G+ IDF KLYW + I NLDGS +
Sbjct: 1721 GDNISMANMDGSNRTLLFSGQK-GPVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVI 1779
Query: 680 --TQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVVVH-- 735
++ +G A+A+ D +W++D + +K G V +L+ S+ +V+H
Sbjct: 1780 DAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSV-----VLRNSTTLVMHMK 1834
Query: 736 ------PLAKPGADPCLYQNGGCEHICKKRLGTA-WCSCREGFMKASDGKTC 780
L G +PC NG C +C T C C G+ S + C
Sbjct: 1835 VYDESIQLDHKGTNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQAC 1886
Score = 134 bits (338), Expect = 4e-31
Identities = 151/581 (25%), Positives = 232/581 (39%), Gaps = 61/581 (10%)
Query: 394 RCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVP 453
R H S R + + D V G + V RD + + + NGGC QLC+
Sbjct: 2113 RTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLY 2172
Query: 454 LSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDYGTLLS----- 508
C C G L D SC +LL++ ++ +H +D L +
Sbjct: 2173 RGRGQRACACAHGM-LAEDGASCREYAG--YLLYSERTILKSIHL--SDERNLNAPVQPF 2227
Query: 509 ---QQMGMVYALDHD-------PVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPE 558
+ M V AL D N+I+F+ I++ N DGS+R ++E V E
Sbjct: 2228 EDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRITIVEN-VGSVE 2286
Query: 559 GLAVDWIGRRFYWTDRGKSLIGRSDLNG------KRSKIITKENISQPRGIAVHPMAKRL 612
GLA YWT S I R ++ +R +IT PR + +
Sbjct: 2287 GLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFVLDECQNLM 2346
Query: 613 FWTDTGI-NPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANL 671
FWT+ +P I ++L G L + D+ P+G+ ID +KLY+ DA IE
Sbjct: 2347 FWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEY 2406
Query: 672 DGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSM-LKPSS 730
DGS R + +++ HPF +AV+ ++++++DW +V R NK G + L+ + +P
Sbjct: 2407 DGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMG 2466
Query: 731 LV-VVHPLAKPGADPCLYQNGGCEHIC-KKRLGTAWCSCREGFMKASDGKTCLALDGHQL 788
++ V + PC NGGC+ +C G CSCR G + D TC A++
Sbjct: 2467 IIAVANDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRI-LQDDLTCRAVNS-SC 2524
Query: 789 LAGGEVDLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCIS 848
A E + N L+ V D+ D P C+ RC
Sbjct: 2525 RAQDEFECANGECINFSLTCDGVPH---------------CKDKSDEKPSYCNS-RRC-- 2566
Query: 849 EGEDATCQCLKGFAGDGKL-CSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEG-YQGD 906
+ QC G L C+ D+C G P + C G RC +G G+
Sbjct: 2567 --KKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNKTAC----GVGEFRCRDGTCIGN 2620
Query: 907 GIHCLDIDECQLGEHSCGENASCTNTEGGYTCMCAGRLSEP 947
C +C+ + S N S T+ + G L +P
Sbjct: 2621 SSRCNQFVDCE--DASDEMNCSATDCSSYFRLGVKGVLFQP 2659
Score = 127 bits (319), Expect = 6e-29
Identities = 90/325 (27%), Positives = 159/325 (48%), Gaps = 29/325 (8%)
Query: 46 PFLIFSHGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQ--LLQRVFL 103
PFLIF++ + +++ +G+NY L +V +DF Y E+ IYW D+ Q +++R+ L
Sbjct: 3029 PFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHL 3088
Query: 104 NGSRQERVCNIE-KNVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSA-LKYPA 161
NGS + + N G+A++W+ + W ++ I V+ + G +L+S+ L+ P
Sbjct: 3089 NGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPR 3148
Query: 162 NVAVDPVERFIFWSSEVAGSLY-RADLDGVGVKALLETSEKIT---AVSLDVLDKRLFWI 217
+ VD +++W+ SL R +DG +++T KIT ++LD + +R++W
Sbjct: 3149 ALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDT--KITWPNGLTLDYVTERIYW- 3205
Query: 218 QYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTG 277
+ I DG + H+ ++FA++LF D ++++ W+ K+I A+K TG
Sbjct: 3206 ---ADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTG 3262
Query: 278 --KDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQ 335
K ++ LH +L V H L QP + CK+ G CS+
Sbjct: 3263 TNKTLLISTLHRPM----DLHVFHALRQPDVPNHP-------CKVNNGGCSNLCLLSPGG 3311
Query: 336 SHLCMCAEGYALSRDRKYCEDVNEC 360
H C C + L D + C V+ C
Sbjct: 3312 GHKCACPTNFYLGSDGRTC--VSNC 3334
Score = 112 bits (279), Expect = 3e-24
Identities = 74/343 (21%), Positives = 153/343 (44%), Gaps = 29/343 (8%)
Query: 27 SCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYEQL----VVDAGVSVIMDFH 82
+CP N+TC FL+++ I +D + Y + V D ++D+
Sbjct: 1564 ACPHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVLDYD 1623
Query: 83 YNEKRIYWVDLERQLLQRVFLNGSRQERVCNIE-KNVSGMAINWINEEVIWS--NQQEGI 139
E+R+YW D+ Q ++R F+NG+ E V + + N G+A++W++ + W+ + +
Sbjct: 1624 AREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQ 1683
Query: 140 ITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALLETS 199
I V + G+ + ++ L+ P + V P+ ++W+ ++ A++DG L
Sbjct: 1684 INVARLDGSFKNAVVQGLEQPHGLVVHPLRGKLYWTD--GDNISMANMDGSNRTLLFSGQ 1741
Query: 200 EKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHI--SKHPTQHNLFAMSLFGD 257
+ +++D + +L+WI N I C+ DG + + + A+++ GD
Sbjct: 1742 KGPVGLAIDFPESKLYWI----SSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAIMGD 1797
Query: 258 RIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQK- 316
+++++ + + +K G V + ++ V K D++ + + K
Sbjct: 1798 KLWWADQVSEKMGTCSKADGSGSVVLRNSTTLV-----------MHMKVYDESIQLDHKG 1846
Query: 317 --LCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDV 357
C + G+CS + CMC GY+L ++ CE V
Sbjct: 1847 TNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQACEGV 1889
Score = 108 bits (271), Expect = 2e-23
Identities = 90/344 (26%), Positives = 159/344 (46%), Gaps = 28/344 (8%)
Query: 27 SCPEGTLAGNGNSTC--VGP-APFLIFSHGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHY 83
SC EG + +C + P PF+IFS+ + I RID +Y LV ++ +DFH
Sbjct: 1247 SCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALDFHL 1306
Query: 84 NEKRIYWVDLERQLLQRVFL--NGSRQERVCNIEKNVS---GMAINWINEEVIWSNQQEG 138
++ +YW D+ + R L NG+ I+ ++ G+A++WI + W
Sbjct: 1307 SQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLD 1366
Query: 139 IITVTDMKGN-NSHILLSALKYPANVAVDPVERFIFWSSEVAG--SLYRADLDGVGVKAL 195
I V + G + +L +++P +A+DP + +FW+ A + A + G G + +
Sbjct: 1367 QIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTV 1426
Query: 196 LETSEK---ITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDG-GSVHISK-HPTQHNLF 250
+ +++D L+KR+ WI + + I S YDG G + + + H + F
Sbjct: 1427 HRETGSGGWPNGLTVDYLEKRILWI----DARSDAIYSARYDGSGHMEVLRGHEFLSHPF 1482
Query: 251 AMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDT 310
A++L+G ++++ W+ T+ ANK TG + V + ++ P +L+V HP QP A
Sbjct: 1483 AVTLYGGEVYWTDWRTNTLAKANKWTGHN-VTVVQRTNTQPF-DLQVYHPSRQPMA---- 1536
Query: 311 WEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYC 354
P +G CS ++ C C L +D C
Sbjct: 1537 --PNPCEANGGQGPCSHLCLINYNRTVSCACPHLMKLHKDNTTC 1578
Score = 85.1 bits (209), Expect = 4e-16
Identities = 79/338 (23%), Positives = 141/338 (41%), Gaps = 23/338 (6%)
Query: 28 CPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAG---VSVIMDFHYN 84
C G +G C G FL++S I I + + +V ++V +DFH
Sbjct: 1873 CTAGYSLRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAE 1932
Query: 85 EKRIYWVDLERQLLQRVFLNGS-RQERVCNIEKNVSGMAINWINEEVIWSNQQEGIITVT 143
IYWVD+ + R + + R++ V N V G+A++WI + W++Q +I V
Sbjct: 1933 NDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVA 1992
Query: 144 DMKGNNSHILLS-ALKYPANVAVDPVERFIFWSS-EVAGSLYRADLDGVGVKALLETS-E 200
+ G+ ++++S L P + V P + ++FW+ + R+ LDG L+ S
Sbjct: 1993 RLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVNVSIS 2052
Query: 201 KITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIF 260
+S+D D +L+W + + G + + ++F++S+F D I+
Sbjct: 2053 WPNGISVDYQDGKLYWCDARTDKIERIDLE---TGENREVVLSSNNMDMFSVSVFEDFIY 2109
Query: 261 YS--TWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLC 318
+S T +I +K D V + V L ++KV + Q +C
Sbjct: 2110 WSDRTHANGSIKRGSKDNATDSVPLRTGIG-VQLKDIKVFNRDRQKGT---------NVC 2159
Query: 319 KLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCED 356
+ G C + C CA G L+ D C +
Sbjct: 2160 AVANGGCQQLCLYRGRGQRACACAHG-MLAEDGASCRE 2196
Score = 79.3 bits (194), Expect = 2e-14
Identities = 94/396 (23%), Positives = 162/396 (40%), Gaps = 62/396 (15%)
Query: 87 RIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSGMAINWINEEVIWSNQQEGIITVTDMK 146
RI++ D+ +Q++ +GSR+ + +V G+A + + + W++ IT +
Sbjct: 2254 RIFFSDIHFGNIQQINDDGSRRITIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVD 2313
Query: 147 GNN-------SHILLSALKYPANVAVDPVERFIFWSS--EVAGSLYRADLDGVGVKALLE 197
+ I +S +P +D + +FW++ E S+ RA L G V L+E
Sbjct: 2314 QTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIE 2373
Query: 198 TSEKI-TAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFG 256
+ +++D ++L++ + + I C+YDG ++ + F ++++G
Sbjct: 2374 KDIRTPNGLAIDHRAEKLYF----SDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYG 2429
Query: 257 DRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQK 316
+ IF++ W + + ANKH G +M + + P+G + V +DT E
Sbjct: 2430 EHIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVA---------NDTNSCELS 2480
Query: 317 LCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVN---------ECAFWNHGC 367
C++ G C +C Q H+ G + +D C VN ECA N C
Sbjct: 2481 PCRINNGGCQD-LCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFECA--NGEC 2537
Query: 368 ---TLGCKNTP--------GSYYCT---CPVGFVLLPDGKRCHQLVSCPRNVSEC--SHD 411
+L C P YC C F +G+ C N+ C + D
Sbjct: 2538 INFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGR-------CVSNMLWCNGADD 2590
Query: 412 CVLTSEGPLC---FCPEGSVLERDGKTCSGCSSPDN 444
C S+ C C G RDG TC G SS N
Sbjct: 2591 CGDGSDEIPCNKTACGVGEFRCRDG-TCIGNSSRCN 2625
Score = 77.0 bits (188), Expect = 1e-13
Identities = 109/496 (21%), Positives = 199/496 (40%), Gaps = 75/496 (15%)
Query: 28 CPEGTLAGNGNSTCVGPAP--FLIFSHGN-SIFRIDTEGTNYEQLVVDAGVSVI------ 78
C G G+ +C P FL++ G I R G + V D + I
Sbjct: 506 CRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIR----GMDMGAKVPDEHMIPIENLMNP 561
Query: 79 --MDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIE-KNVSGMAINWINEEVIWSNQ 135
+DFH IY+ D L+ R ++G+ +E + NV G+A++W+ + + W++
Sbjct: 562 RALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDD 621
Query: 136 -QEGIITVTDMK---GNNSHILLSALKYPANVAVDPVERFIFWS-------SEVAGSLYR 184
+ I+V ++ ++ + +P + VDP+ +++W+ G L R
Sbjct: 622 GPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLER 681
Query: 185 ADLDGVGVKALLETSEKI---TAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHIS 241
A +DG + + TS+ + +SLD+ RL+W+ + +++ + D V+
Sbjct: 682 AWMDG-SHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLN-GTDRKIVY-- 737
Query: 242 KHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRIN-LHSSFVPLGELKVVHP 300
+ P ++ F + G+ +F++ ++ +++ + G + L S P+ E+++
Sbjct: 738 EGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDA 797
Query: 301 LAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNEC 360
Q + C++ G CSS +C S C CAE L D C
Sbjct: 798 QQQQVGTNK--------CRVNNGGCSS-LCLATPGSRQCACAEDQVLDADGVTC------ 842
Query: 361 AFWNHGCTLGCKNTPGSYYCT----------CPVGFVLLPDGKR----CHQLVSCPRNVS 406
N + PG + C C L + CHQ +CP +
Sbjct: 843 -LANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQ-HTCPSDRF 900
Query: 407 ECSHDCVLTSEGPLCFCPE--GSVLERDGKTCSGCSSPDN--GGCSQLCVPLSPVSWECD 462
+C ++ + + LC G+ + TCS + P N S C+ P+SW CD
Sbjct: 901 KCENNRCIPNRW-LCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCI---PISWTCD 956
Query: 463 CFPGYDLQLDEK-SCA 477
+ DE SCA
Sbjct: 957 LDDDCGDRSDESASCA 972
Score = 66.6 bits (161), Expect = 1e-10
Identities = 94/418 (22%), Positives = 163/418 (38%), Gaps = 53/418 (12%)
Query: 79 MDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEK----------NVSGM------A 122
MD H R+YW + + L + N + N+SG+ A
Sbjct: 3905 MDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIA 3964
Query: 123 INWINEEVIWSNQQEGIITVTDMKGNNSHILLSA-LKYPANVAVDPVERFIFWSS-EVAG 180
I+W+ V W++ +I V MKG N L+S + P + VDP+ ++WS
Sbjct: 3965 IDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHP 4024
Query: 181 SLYRADLDGVGVKALLETS-EKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVH 239
+ A +DG + L++ + + T +++D ++RL+W + S+I S +G
Sbjct: 4025 KIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYW----ADAKLSVIGSIRLNGTDPI 4080
Query: 240 I---SKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELK 296
+ SK H F++ +F D I+ T+ ++ +K +V NL ++
Sbjct: 4081 VAADSKRGLSHP-FSIDVFEDYIYGVTYINNRVFKIHKFGHSPLV--NLTGGLSHASDVV 4137
Query: 297 VVHPLAQPKAEDDTWEPEQKLCK-LRKGNCSSTVC----GQDLQSHLCMCAEGYALSRDR 351
+ H QP+ + ++K C+ L + S VC G+ L + C+ D
Sbjct: 4138 LYHQHKQPEVTNPC---DRKKCEWLCLLSPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDA 4194
Query: 352 KYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHD 411
N F C L + P C C + G +C +L C +
Sbjct: 4195 PRPGTCNLQCFNGGSCFLNARRQP---KCRCQPRYT----GDKC-ELDQCWEHCRNGGTC 4246
Query: 412 CVLTSEGPLCFCPEGSVLER-DGKTCSG-CSSPDNGGCSQLCVPLSPVSWECDCFPGY 467
S P C CP G + + C+G C++ +Q P +C C PG+
Sbjct: 4247 AASPSGMPTCRCPTGFTGPKCTQQVCAGYCANNSTCTVNQGNQP------QCRCLPGF 4298
Score = 63.5 bits (153), Expect = 1e-09
Identities = 84/379 (22%), Positives = 144/379 (37%), Gaps = 47/379 (12%)
Query: 28 CPEGTLAGNGNSTC------VGPAPFLIFSHGNSIFRIDTEGTNYEQLV-VDAGVSVIMD 80
C EG L N +C V P L+ ++ +I G + + MD
Sbjct: 175 CVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMD 234
Query: 81 FHYNEKRIYWVDLERQLLQRVF-------LNGSRQERVCNIE---KNVSGMAINWINEEV 130
F Y + + WV + Q L G E NI +V MAI+W+
Sbjct: 235 FSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNF 294
Query: 131 IWSNQQEGIITVTDMKGNNSHILLSALKY-PANVAVDPVERFIFWSSE-VAGSLYRADLD 188
+ + + I V + G+ LL Y P +A+DP +F++ + R D+D
Sbjct: 295 YFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMD 354
Query: 189 GVGVKALLETSEKIT-AVSLDVLDKRLFWIQYNREGSNSLICSCDYDG-GSVHISKHPTQ 246
G L+++ ++LD++ + ++W + I DY+G G I +
Sbjct: 355 GQNRTKLVDSKIVFPHGITLDLVSRLVYWA----DAYLDYIEVVDYEGKGRQTIIQGILI 410
Query: 247 HNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPL--------GELKVV 298
+L+ +++F + Y+T AN ++R+N +S G L +
Sbjct: 411 EHLYGLTVF-ENYLYATNSDN----ANAQQKTSVIRVNRFNSTEYQVVTRVDKGGALHIY 465
Query: 299 HPLAQPKAEDDTWEPEQKLCKLRKGNCSST-VCGQDLQSHLCMCAEGYALSRDRKYCEDV 357
H QP+ E +Q + G CS + ++ C C G++L D K C+
Sbjct: 466 HQRRQPRVRSHACENDQYG---KPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKP 522
Query: 358 NECAFWNHGCTLGCKNTPG 376
F +G K PG
Sbjct: 523 EHELFLVYG-----KGRPG 536
Score = 60.5 bits (145), Expect = 1e-08
Identities = 29/82 (35%), Positives = 41/82 (50%), Gaps = 5/82 (6%)
Query: 318 CKLRKGNCSSTVCGQD----LQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKN 373
C+ +GNCS C L C C + L D K C+D +EC+ + C+ C N
Sbjct: 108 CRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGT-CSQLCTN 166
Query: 374 TPGSYYCTCPVGFVLLPDGKRC 395
T GS+ C C G++L PD + C
Sbjct: 167 TDGSFICGCVEGYLLQPDNRSC 188
Score = 57.0 bits (136), Expect = 1e-07
Identities = 31/83 (37%), Positives = 40/83 (48%), Gaps = 10/83 (12%)
Query: 832 QDDCAPVGCSMYARCISEGEDATCQCLKGFA--GDGKLCSDIDECEMGVPVCPPASSKCI 889
Q +C+ +GC + C+ + TC C F DGK C D DEC V S C
Sbjct: 112 QGNCSRLGCQHH--CVPTLDGPTCYCNSSFQLQADGKTCKDFDECS----VYGTCSQLCT 165
Query: 890 NTEGGYVCRCSEGY--QGDGIHC 910
NT+G ++C C EGY Q D C
Sbjct: 166 NTDGSFICGCVEGYLLQPDNRSC 188
Score = 48.1 bits (113), Expect = 5e-05
Identities = 33/99 (33%), Positives = 47/99 (47%), Gaps = 10/99 (10%)
Query: 845 RCISEGEDATCQCLKGFAGDGKLCSDIDEC-EMGVPVCPPASSKCINTEGGYVCRCSEGY 903
RC++E Q G + D + C I+EC + C S C + + G+ CRC G+
Sbjct: 2916 RCVAEALLCNGQDDCGDSSDERGCH-INECLSRKLSGC---SQDCEDLKIGFKCRCRPGF 2971
Query: 904 Q--GDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMC 940
+ DG C D+DEC C + C NT G Y C+C
Sbjct: 2972 RLKDDGRTCADVDECST-TFPCSQR--CINTHGSYKCLC 3007
Score = 47.0 bits (110), Expect = 1e-04
Identities = 26/81 (32%), Positives = 35/81 (43%), Gaps = 1/81 (1%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGS 377
C L G CS + +C C G L D C+ + CA + C+ C S
Sbjct: 1185 CSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCA-KHLKCSQKCDQNKFS 1243
Query: 378 YYCTCPVGFVLLPDGKRCHQL 398
C+C G+VL PDG+ C L
Sbjct: 1244 VKCSCYEGWVLEPDGESCRSL 1264
Score = 45.1 bits (105), Expect = 4e-04
Identities = 36/132 (27%), Positives = 52/132 (39%), Gaps = 18/132 (13%)
Query: 831 DQDDCAPVGCSMYARCISEGEDATCQCLKGFAGDGKLCSDIDECEMGV---PVCPPASSK 887
D D AP C + + C + +LC+ + +C G P C
Sbjct: 55 DGSDEAPEICPQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGN 114
Query: 888 C---------INTEGGYVCRCSEGYQ--GDGIHCLDIDECQLGEHSCGENASCTNTEGGY 936
C + T G C C+ +Q DG C D DEC + +C + CTNT+G +
Sbjct: 115 CSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSV-YGTCSQ--LCTNTDGSF 171
Query: 937 TCMCA-GRLSEP 947
C C G L +P
Sbjct: 172 ICGCVEGYLLQP 183
Score = 45.1 bits (105), Expect = 4e-04
Identities = 31/104 (29%), Positives = 45/104 (43%), Gaps = 16/104 (15%)
Query: 840 CSMYARCISEGEDATCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRC 899
C+M+ C ++ C D KL S C +C ++C+ TE C C
Sbjct: 3761 CNMFDDCGDGSDEEDCSI------DPKLTS----CATNASICGD-EARCVRTEKAAYCAC 3809
Query: 900 SEGYQG--DGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMCA 941
G+ C DI+EC L +C + C NT+GG+ C CA
Sbjct: 3810 RSGFHTVPGQPGCQDINEC-LRFGTCSQ--LCNNTKGGHLCSCA 3850
Score = 43.5 bits (101), Expect = 0.001
Identities = 22/82 (26%), Positives = 37/82 (45%), Gaps = 2/82 (2%)
Query: 307 EDDTWEPEQKLCKLRKGNCSSTV-CGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNH 365
ED + +P+ C C C + ++ C C G+ + C+D+NEC +
Sbjct: 3774 EDCSIDPKLTSCATNASICGDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFG- 3832
Query: 366 GCTLGCKNTPGSYYCTCPVGFV 387
C+ C NT G + C+C F+
Sbjct: 3833 TCSQLCNNTKGGHLCSCARNFM 3854
Score = 42.0 bits (97), Expect = 0.004
Identities = 27/87 (31%), Positives = 39/87 (44%), Gaps = 17/87 (19%)
Query: 830 SDQDDCA-----------PVGCSMYARCISEGEDATCQCLKGF--AGDGKLCSDIDECEM 876
SD++DC+ C ARC+ + A C C GF C DI+EC +
Sbjct: 3771 SDEEDCSIDPKLTSCATNASICGDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINEC-L 3829
Query: 877 GVPVCPPASSKCINTEGGYVCRCSEGY 903
C S C NT+GG++C C+ +
Sbjct: 3830 RFGTC---SQLCNNTKGGHLCSCARNF 3853
Score = 34.7 bits (78), Expect = 0.56
Identities = 14/34 (41%), Positives = 16/34 (47%)
Query: 751 GCEHICKKRLGTAWCSCREGFMKASDGKTCLALD 784
GC+H C L C C F +DGKTC D
Sbjct: 119 GCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFD 152
Score = 33.5 bits (75), Expect = 1.3
Identities = 30/114 (26%), Positives = 45/114 (39%), Gaps = 20/114 (17%)
Query: 885 SSKCINTEGGYVCRCSEG--YQGDGIHCL------DIDECQLGEHSCGENASCTNTEGGY 936
SS C+ T G C C+E DG+ CL +CQ GE +C N+ C +
Sbjct: 815 SSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACA-NSRCIQER--W 871
Query: 937 TC----MCAGRLSEPGLICPDSTPPPHLREDDHHYSVRN-----SDSECPLSHD 981
C C E +C T P + +++ + N D++C S D
Sbjct: 872 KCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSED 925
Score = 31.6 bits (70), Expect = 4.8
Identities = 15/37 (40%), Positives = 19/37 (51%), Gaps = 1/37 (2%)
Query: 323 GNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNE 359
G CS +C S +C C EGY L D + C+ NE
Sbjct: 158 GTCSQ-LCTNTDGSFICGCVEGYLLQPDNRSCKAKNE 193
Score = 31.2 bits (69), Expect = 6.2
Identities = 12/33 (36%), Positives = 19/33 (57%)
Query: 752 CEHICKKRLGTAWCSCREGFMKASDGKTCLALD 784
C C + + CSC EG++ DG++C +LD
Sbjct: 1233 CSQKCDQNKFSVKCSCYEGWVLEPDGESCRSLD 1265
Score = 30.8 bits (68), Expect = 8.1
Identities = 15/37 (40%), Positives = 21/37 (56%), Gaps = 1/37 (2%)
Query: 443 DNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAAS 479
+NGGCS LC+ +P S +C C L D +C A+
Sbjct: 810 NNGGCSSLCL-ATPGSRQCACAEDQVLDADGVTCLAN 845
>gi|119709832 low density lipoprotein receptor-related protein 5
[Homo sapiens]
Length = 1615
Score = 250 bits (638), Expect = 7e-66
Identities = 187/755 (24%), Positives = 325/755 (43%), Gaps = 152/755 (20%)
Query: 41 CVGPA---PFLIFSHGNSIFRIDTEGTNYEQLVVDAGV--SVIMDFHYNEKRIYWVDLER 95
C PA P L+F++ + +D G E +V +G+ + +DF +++ +YW D+
Sbjct: 25 CPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSE 84
Query: 96 QLLQRVFLNGSRQERVCNIEKNVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILLS 155
+ +++ +LN + G A+ ++++S
Sbjct: 85 EAIKQTYLNQT-------------GAAVQ--------------------------NVVIS 105
Query: 156 ALKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALL-ETSEKITAVSLDVLDKRL 214
L P +A D V + ++W+ + A+L+G K L + ++ A++LD +
Sbjct: 106 GLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYM 165
Query: 215 FWIQYNREGSNSLICSCDYDGGS--VHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIA 272
+W + G I DG + + + N + L +++++ K+ I
Sbjct: 166 YWTDW---GETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIH-- 220
Query: 273 NKHTGKDMVRINLHSSF-VPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVCG 331
R NL SF + E + HP A + D + + + + N +
Sbjct: 221 ---------RANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGKR 271
Query: 332 QDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPD 391
+++ S L + LS++R+ ++ T
Sbjct: 272 KEILSALYSPMDIQVLSQERQ------------------------PFFHT---------- 297
Query: 392 GKRCHQLVSCPRNVSECSHDCVLTSEGPL--CFCPEGSVLERDGKTCSGCSSPDNGGCSQ 449
C + CSH C+L+ P C CP G L+ +G+TC
Sbjct: 298 --------RCEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCK------------ 337
Query: 450 LCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDYGTLLSQ 509
+G + LL A D+R + D D+ ++ Q
Sbjct: 338 -----------------------------AGAEEVLLLARRTDLRRISLDTPDFTDIVLQ 368
Query: 510 --QMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGR 567
+ A+D+DP+E +Y+ ++ I RA +DGS + L+ ++ P+G+AVDW+ R
Sbjct: 369 VDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVAR 428
Query: 568 RFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSS 627
YWTD G I + LNG KI+ E++ +PR IA+HP+ ++WTD G NP+IE ++
Sbjct: 429 NLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECAN 488
Query: 628 LQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQNDVGHP 687
L G R V+ ++ L WP+G+ +D KLYW DAK IE+ N+DG+KRR L ++ + H
Sbjct: 489 LDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHI 548
Query: 688 FAVAVFEDYVWFSDWAMPSVMRVNK-RTGKDRVRLQGSMLKPSSLVVVHPLAKPGADPCL 746
F + D+++++DW S+ RV+K + +D + Q L L V+ G +PC
Sbjct: 549 FGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQLPDL--MGLKAVNVAKVVGTNPCA 606
Query: 747 YQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCL 781
+NGGC H+C C C G SD KTC+
Sbjct: 607 DRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTCI 641
Score = 204 bits (518), Expect = 5e-52
Identities = 110/327 (33%), Positives = 175/327 (53%), Gaps = 6/327 (1%)
Query: 477 AASGPQPFLLFANSQDIRHMHFDGTDY-GTLLSQQMGMVYALDHDPVENKIYFAHTALKW 535
A + P LLFAN +D+R + G T++ + A+D + +Y+ + +
Sbjct: 27 APAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEA 86
Query: 536 IERA--NMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIIT 593
I++ N G+ + ++ G+ P+GLA DW+G++ YWTD + I ++LNG K++
Sbjct: 87 IKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLF 146
Query: 594 KENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLT 653
+++ QPR IA+ P ++WTD G PRIE + + G R +I SD+ WP+G+TID
Sbjct: 147 WQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEE 206
Query: 654 DKLYWCDAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKR 713
KLYW DAK S I ANLDGS R+++ + + HPFA+ + D ++++DW S+ NKR
Sbjct: 207 QKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKR 266
Query: 714 TGKDRVRLQGSMLKPSSLVVVHPLAKPGADP-CLYQNGGCEHICKKRLGTAW--CSCREG 770
TG R + ++ P + V+ +P C NGGC H+C + C+C G
Sbjct: 267 TGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEPFYTCACPTG 326
Query: 771 FMKASDGKTCLALDGHQLLAGGEVDLK 797
+G+TC A LL DL+
Sbjct: 327 VQLQDNGRTCKAGAEEVLLLARRTDLR 353
Score = 198 bits (503), Expect = 3e-50
Identities = 106/339 (31%), Positives = 181/339 (53%), Gaps = 8/339 (2%)
Query: 444 NGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDY 503
NGGCS LC +P + C C G +L D K+C P+ FL+F + I + + T+
Sbjct: 609 NGGCSHLCF-FTPHATRCGCPIGLELLSDMKTCIV--PEAFLVFTSRAAIHRISLE-TNN 664
Query: 504 GTLLSQQMGM--VYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLA 561
+ G+ ALD D N IY+ +LK I RA M+GS E ++E G+D PEG+A
Sbjct: 665 NDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMA 724
Query: 562 VDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINP 621
VDW+G+ YW D G + I + L+G+ +++ ++ PR +A+ P ++WT+ G P
Sbjct: 725 VDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKP 784
Query: 622 RIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQ 681
RI + + G + + + + +TID+ +LYW D ++IE +N+ G + R +
Sbjct: 785 RIVRAFMDGTNCMTLVDK-VGRANDLTIDYADQRLYWTDLDTNMIESSNMLG-QERVVIA 842
Query: 682 NDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAKPG 741
+D+ HPF + + DY++++DW + S+ R +K +G++R +QG + ++V H + G
Sbjct: 843 DDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDG 902
Query: 742 ADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTC 780
+ C++ NG C +C G C C + + C
Sbjct: 903 LNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNC 941
Score = 144 bits (362), Expect = 7e-34
Identities = 105/349 (30%), Positives = 165/349 (47%), Gaps = 15/349 (4%)
Query: 443 DNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTD 502
+NG C QLC+ + P C C Y L ++C S P FLLF+ I M D
Sbjct: 909 NNGQCGQLCLAI-PGGHRCGCASHYTLDPSSRNC--SPPTTFLLFSQKSAISRMIPDDQH 965
Query: 503 YGTLLSQQMGM--VYALDHDPVENKIYFAHTALKWIERANMDGSQRERL--IEEGVDV-- 556
L+ G+ V A+D+DP++ IY+ I+RA DG+Q L + +G +
Sbjct: 966 SPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQN-IKRAKDDGTQPFVLTSLSQGQNPDR 1024
Query: 557 -PEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWT 615
P L++D R +WT + I L+G+ ++ + + +PR I V+ L++T
Sbjct: 1025 QPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFT 1084
Query: 616 DTGINP-RIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGS 674
+ +IE ++L G R V+ ++ LI P + +D KL+W DA IE +L G+
Sbjct: 1085 NMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGA 1144
Query: 675 KRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVVV 734
R L ++ P + + ++++ D + RV K TG R R+QG + + + V
Sbjct: 1145 NRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAV 1204
Query: 735 H--PLAKPGADPCLYQNGGCEHIC-KKRLGTAWCSCREGFMKASDGKTC 780
L + A PC NGGC HIC K GT CSC + + TC
Sbjct: 1205 EEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTC 1253
Score = 122 bits (306), Expect = 2e-27
Identities = 89/336 (26%), Positives = 150/336 (44%), Gaps = 30/336 (8%)
Query: 28 CPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGV--SVIMDFHYNE 85
CP G + TC+ P FL+F+ +I RI E N + + GV + +DF +
Sbjct: 627 CPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISLETNNNDVAIPLTGVKEASALDFDVSN 686
Query: 86 KRIYWVDLERQLLQRVFLNGSRQERVCNIEKNV-SGMAINWINEEVIWSNQQEGIITVTD 144
IYW D+ + + R F+NGS E V + GMA++W+ + + W++ I V
Sbjct: 687 NHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVAR 746
Query: 145 MKGNNSHILL-SALKYPANVAVDPVERFIFWSSEVAGS--LYRADLDGVGVKALLETSEK 201
+ G +L+ L P ++A+DP + +I+W +E G + RA +DG L++ +
Sbjct: 747 LDGQFRQVLVWRDLDNPRSLALDPTKGYIYW-TEWGGKPRIVRAFMDGTNCMTLVDKVGR 805
Query: 202 ITAVSLDVLDKRLFWIQYNR---EGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDR 258
+++D D+RL+W + E SN L G + + F ++ + D
Sbjct: 806 ANDLTIDYADQRLYWTDLDTNMIESSNML--------GQERVVIADDLPHPFGLTQYSDY 857
Query: 259 IFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLC 318
I+++ W + +I A+K +G++ I H FV ++ V H Q D C
Sbjct: 858 IYWTDWNLHSIERADKTSGRNRTLIQGHLDFVM--DILVFHSSRQDGLND---------C 906
Query: 319 KLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYC 354
G C +C H C CA Y L + C
Sbjct: 907 MHNNGQCGQ-LCLAIPGGHRCGCASHYTLDPSSRNC 941
Score = 67.4 bits (163), Expect = 8e-11
Identities = 96/457 (21%), Positives = 171/457 (37%), Gaps = 107/457 (23%)
Query: 41 CVGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDA-GVSVIMDFHYN--EKRIYWVDLERQL 97
C P FL+FS ++I R+ + + L++ G+ + Y+ +K IYWVD RQ
Sbjct: 941 CSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVD-GRQN 999
Query: 98 LQRVFLNGSRQ------ERVCNIEKNVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSH 151
++R +G++ + N ++ ++I+ + + W+ + I V + G
Sbjct: 1000 IKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMG 1059
Query: 152 ILLSALK-YPANVAVDPVERFIFWSS--EVAGSLYRADLDGVGVKALLETSE-KITAVSL 207
++L + P + V+ ++++++ + A + RA LDG + L T + A+ +
Sbjct: 1060 VVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVV 1119
Query: 208 DVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFYSTWKMK 267
D +LFW+ + I SCD G + + +++ G +++ + +
Sbjct: 1120 DNTLGKLFWV----DADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQ 1175
Query: 268 TIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSS 327
I K TG RI + L +H + + E+ + P C G CS
Sbjct: 1176 MIERVEKTTGDKRTRIQGR-----VAHLTGIHAVEEVSLEEFSAHP----CARDNGGCS- 1225
Query: 328 TVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFV 387
H+C+ A+G G+ C+CPV V
Sbjct: 1226 ---------HICI-AKG------------------------------DGTPRCSCPVHLV 1245
Query: 388 LLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDNGGC 447
LL L++C E P C SPD C
Sbjct: 1246 LL------QNLLTC--------------GEPPTC-------------------SPDQFAC 1266
Query: 448 SQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPF 484
+ + P +W CD FP D Q DE+ C F
Sbjct: 1267 ATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQF 1303
>gi|61744471 low density lipoprotein receptor-related protein 8
isoform 1 precursor [Homo sapiens]
Length = 963
Score = 240 bits (613), Expect = 5e-63
Identities = 145/420 (34%), Positives = 217/420 (51%), Gaps = 30/420 (7%)
Query: 382 CPVGFVLLPDGKRCHQ-LVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSG-- 438
CP G D C Q L C N CSH C G C CP G L D KTC
Sbjct: 324 CPDG----SDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGDID 378
Query: 439 -CSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC-AASGPQPFLLFANSQDIRHM 496
C PD CSQ+CV ++C+C+PGY++ L K+C AA+G P L+F N ++R +
Sbjct: 379 ECKDPD--ACSQICVNYKGY-FKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRI 435
Query: 497 HFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGS----QRERLIEE 552
+Y L+ +V ALD + N+IY+ + + I A MD + ++E LI+E
Sbjct: 436 DLVKRNYSRLIPMLKNVV-ALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDE 494
Query: 553 GVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRL 612
+ PEGLAVDW+ + YWTD G I + ++G R + + N+S+PR IAV P+ +
Sbjct: 495 QLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFM 554
Query: 613 FWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLD 672
+W+D G +IE S L G+ R + S ++ WP+GIT+D L+ +LYW D+K + +
Sbjct: 555 YWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFS 614
Query: 673 GSKRRRLTQND--VGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSS 730
G R+ L + + HPF +AVFED V+++D ++ N+ G + L ++ P
Sbjct: 615 GGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHD 674
Query: 731 LVVVHPLAKPGA-DPC---LYQNGGCEHIC------KKRLGTAWCSCREGFMKASDGKTC 780
+V+ H L +P A D C + NGGCE++C C+C + D K C
Sbjct: 675 IVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734
Score = 107 bits (268), Expect = 5e-23
Identities = 100/428 (23%), Positives = 189/428 (44%), Gaps = 66/428 (15%)
Query: 43 GPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVF 102
G +P LIF++ + + RID NY +L+ V +D RIYW DL + + +
Sbjct: 419 GKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAY 478
Query: 103 LNGS---RQERVCNIEK--NVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSA- 156
++ + +++ V E+ + G+A++W+++ + W++ I+V + G L S
Sbjct: 479 MDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRN 538
Query: 157 LKYPANVAVDPVERFIFWSS-EVAGSLYRADLDGVGVKALL-ETSEKITAVSLDVLDKRL 214
L P +AVDP+ F++WS + ++ L+GV + L+ + E ++LD+L +RL
Sbjct: 539 LSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRL 598
Query: 215 FWIQYNREGSNSLICSCDYDGGS--VHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIA 272
+W+ + + S D+ GG+ IS + F +++F D++F++ + + I+ A
Sbjct: 599 YWV----DSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSA 654
Query: 273 NKHTGKD--MVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVC 330
N+ G + ++ NL++ ++ + H L QP+A D +L G C
Sbjct: 655 NRLNGLEISILAENLNNPH----DIVIFHELKQPRAPDAC-----ELSVQPNGGC----- 700
Query: 331 GQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLP 390
+LC+ A + ++P Y C CP L P
Sbjct: 701 -----EYLCLPAPQIS-------------------------SHSP-KYTCACPDTMWLGP 729
Query: 391 DGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDNGGC--S 448
D KRC++ P++ S + +T P G+ + R +P S
Sbjct: 730 DMKRCYR---APQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPS 786
Query: 449 QLCVPLSP 456
+ VP +P
Sbjct: 787 SVSVPRAP 794
Score = 41.6 bits (96), Expect = 0.005
Identities = 27/70 (38%), Positives = 35/70 (50%), Gaps = 9/70 (12%)
Query: 839 GCSMYARCISEGEDATCQCLKGFAG-DGKLCSDIDECEMGVPVCPPASSK-CINTEGGYV 896
GCS + G + TC GF D K C DIDEC+ P A S+ C+N +G +
Sbjct: 346 GCSHICTDLKIGFECTCPA--GFQLLDQKTCGDIDECKD-----PDACSQICVNYKGYFK 398
Query: 897 CRCSEGYQGD 906
C C GY+ D
Sbjct: 399 CECYPGYEMD 408
Score = 36.6 bits (83), Expect = 0.15
Identities = 24/78 (30%), Positives = 33/78 (42%), Gaps = 3/78 (3%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGS 377
C G CS +C C C G+ L D+K C D++EC C+ C N G
Sbjct: 340 CLHNNGGCSH-ICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKD-PDACSQICVNYKGY 396
Query: 378 YYCTCPVGFVLLPDGKRC 395
+ C C G+ + K C
Sbjct: 397 FKCECYPGYEMDLLTKNC 414
>gi|61744467 low density lipoprotein receptor-related protein 8
isoform 3 precursor [Homo sapiens]
Length = 700
Score = 240 bits (613), Expect = 5e-63
Identities = 145/420 (34%), Positives = 217/420 (51%), Gaps = 30/420 (7%)
Query: 382 CPVGFVLLPDGKRCHQ-LVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSG-- 438
CP G D C Q L C N CSH C G C CP G L D KTC
Sbjct: 195 CPDG----SDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGDID 249
Query: 439 -CSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC-AASGPQPFLLFANSQDIRHM 496
C PD CSQ+CV ++C+C+PGY++ L K+C AA+G P L+F N ++R +
Sbjct: 250 ECKDPD--ACSQICVNYKGY-FKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRI 306
Query: 497 HFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGS----QRERLIEE 552
+Y L+ +V ALD + N+IY+ + + I A MD + ++E LI+E
Sbjct: 307 DLVKRNYSRLIPMLKNVV-ALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDE 365
Query: 553 GVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRL 612
+ PEGLAVDW+ + YWTD G I + ++G R + + N+S+PR IAV P+ +
Sbjct: 366 QLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFM 425
Query: 613 FWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLD 672
+W+D G +IE S L G+ R + S ++ WP+GIT+D L+ +LYW D+K + +
Sbjct: 426 YWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFS 485
Query: 673 GSKRRRLTQND--VGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSS 730
G R+ L + + HPF +AVFED V+++D ++ N+ G + L ++ P
Sbjct: 486 GGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHD 545
Query: 731 LVVVHPLAKPGA-DPC---LYQNGGCEHIC------KKRLGTAWCSCREGFMKASDGKTC 780
+V+ H L +P A D C + NGGCE++C C+C + D K C
Sbjct: 546 IVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 605
Score = 108 bits (269), Expect = 4e-23
Identities = 86/335 (25%), Positives = 162/335 (48%), Gaps = 31/335 (9%)
Query: 43 GPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVF 102
G +P LIF++ + + RID NY +L+ V +D RIYW DL + + +
Sbjct: 290 GKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAY 349
Query: 103 LNGS---RQERVCNIEK--NVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSA- 156
++ + +++ V E+ + G+A++W+++ + W++ I+V + G L S
Sbjct: 350 MDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRN 409
Query: 157 LKYPANVAVDPVERFIFWSS-EVAGSLYRADLDGVGVKALL-ETSEKITAVSLDVLDKRL 214
L P +AVDP+ F++WS + ++ L+GV + L+ + E ++LD+L +RL
Sbjct: 410 LSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRL 469
Query: 215 FWIQYNREGSNSLICSCDYDGGS--VHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIA 272
+W+ + + S D+ GG+ IS + F +++F D++F++ + + I+ A
Sbjct: 470 YWV----DSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSA 525
Query: 273 NKHTGKD--MVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCS-STV 329
N+ G + ++ NL++ ++ + H L QP+A D +L G C +
Sbjct: 526 NRLNGLEISILAENLNNPH----DIVIFHELKQPRAPDAC-----ELSVQPNGGCEYLCL 576
Query: 330 CGQDLQSH----LCMCAEGYALSRDRKYC-EDVNE 359
+ SH C C + L D K C D NE
Sbjct: 577 PAPQISSHSPKYTCACPDTMWLGPDMKRCYRDANE 611
Score = 41.6 bits (96), Expect = 0.005
Identities = 27/70 (38%), Positives = 35/70 (50%), Gaps = 9/70 (12%)
Query: 839 GCSMYARCISEGEDATCQCLKGFAG-DGKLCSDIDECEMGVPVCPPASSK-CINTEGGYV 896
GCS + G + TC GF D K C DIDEC+ P A S+ C+N +G +
Sbjct: 217 GCSHICTDLKIGFECTCPA--GFQLLDQKTCGDIDECKD-----PDACSQICVNYKGYFK 269
Query: 897 CRCSEGYQGD 906
C C GY+ D
Sbjct: 270 CECYPGYEMD 279
Score = 36.6 bits (83), Expect = 0.15
Identities = 24/78 (30%), Positives = 33/78 (42%), Gaps = 3/78 (3%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGS 377
C G CS +C C C G+ L D+K C D++EC C+ C N G
Sbjct: 211 CLHNNGGCSH-ICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKD-PDACSQICVNYKGY 267
Query: 378 YYCTCPVGFVLLPDGKRC 395
+ C C G+ + K C
Sbjct: 268 FKCECYPGYEMDLLTKNC 285
>gi|65301119 low density lipoprotein receptor-related protein 8
isoform 4 precursor [Homo sapiens]
Length = 904
Score = 240 bits (613), Expect = 5e-63
Identities = 145/420 (34%), Positives = 217/420 (51%), Gaps = 30/420 (7%)
Query: 382 CPVGFVLLPDGKRCHQ-LVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSG-- 438
CP G D C Q L C N CSH C G C CP G L D KTC
Sbjct: 324 CPDG----SDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGDID 378
Query: 439 -CSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC-AASGPQPFLLFANSQDIRHM 496
C PD CSQ+CV ++C+C+PGY++ L K+C AA+G P L+F N ++R +
Sbjct: 379 ECKDPD--ACSQICVNYKGY-FKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRI 435
Query: 497 HFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGS----QRERLIEE 552
+Y L+ +V ALD + N+IY+ + + I A MD + ++E LI+E
Sbjct: 436 DLVKRNYSRLIPMLKNVV-ALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDE 494
Query: 553 GVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRL 612
+ PEGLAVDW+ + YWTD G I + ++G R + + N+S+PR IAV P+ +
Sbjct: 495 QLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFM 554
Query: 613 FWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLD 672
+W+D G +IE S L G+ R + S ++ WP+GIT+D L+ +LYW D+K + +
Sbjct: 555 YWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFS 614
Query: 673 GSKRRRLTQND--VGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSS 730
G R+ L + + HPF +AVFED V+++D ++ N+ G + L ++ P
Sbjct: 615 GGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHD 674
Query: 731 LVVVHPLAKPGA-DPC---LYQNGGCEHIC------KKRLGTAWCSCREGFMKASDGKTC 780
+V+ H L +P A D C + NGGCE++C C+C + D K C
Sbjct: 675 IVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734
Score = 107 bits (268), Expect = 5e-23
Identities = 100/428 (23%), Positives = 189/428 (44%), Gaps = 66/428 (15%)
Query: 43 GPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVF 102
G +P LIF++ + + RID NY +L+ V +D RIYW DL + + +
Sbjct: 419 GKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAY 478
Query: 103 LNGS---RQERVCNIEK--NVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSA- 156
++ + +++ V E+ + G+A++W+++ + W++ I+V + G L S
Sbjct: 479 MDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRN 538
Query: 157 LKYPANVAVDPVERFIFWSS-EVAGSLYRADLDGVGVKALL-ETSEKITAVSLDVLDKRL 214
L P +AVDP+ F++WS + ++ L+GV + L+ + E ++LD+L +RL
Sbjct: 539 LSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRL 598
Query: 215 FWIQYNREGSNSLICSCDYDGGS--VHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIA 272
+W+ + + S D+ GG+ IS + F +++F D++F++ + + I+ A
Sbjct: 599 YWV----DSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSA 654
Query: 273 NKHTGKD--MVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVC 330
N+ G + ++ NL++ ++ + H L QP+A D +L G C
Sbjct: 655 NRLNGLEISILAENLNNPH----DIVIFHELKQPRAPDAC-----ELSVQPNGGC----- 700
Query: 331 GQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLP 390
+LC+ A + ++P Y C CP L P
Sbjct: 701 -----EYLCLPAPQIS-------------------------SHSP-KYTCACPDTMWLGP 729
Query: 391 DGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDNGGC--S 448
D KRC++ P++ S + +T P G+ + R +P S
Sbjct: 730 DMKRCYR---APQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPS 786
Query: 449 QLCVPLSP 456
+ VP +P
Sbjct: 787 SVSVPRAP 794
Score = 41.6 bits (96), Expect = 0.005
Identities = 27/70 (38%), Positives = 35/70 (50%), Gaps = 9/70 (12%)
Query: 839 GCSMYARCISEGEDATCQCLKGFAG-DGKLCSDIDECEMGVPVCPPASSK-CINTEGGYV 896
GCS + G + TC GF D K C DIDEC+ P A S+ C+N +G +
Sbjct: 346 GCSHICTDLKIGFECTCPA--GFQLLDQKTCGDIDECKD-----PDACSQICVNYKGYFK 398
Query: 897 CRCSEGYQGD 906
C C GY+ D
Sbjct: 399 CECYPGYEMD 408
Score = 36.6 bits (83), Expect = 0.15
Identities = 24/78 (30%), Positives = 33/78 (42%), Gaps = 3/78 (3%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGS 377
C G CS +C C C G+ L D+K C D++EC C+ C N G
Sbjct: 340 CLHNNGGCSH-ICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKD-PDACSQICVNYKGY 396
Query: 378 YYCTCPVGFVLLPDGKRC 395
+ C C G+ + K C
Sbjct: 397 FKCECYPGYEMDLLTKNC 414
>gi|148727288 low density lipoprotein receptor-related protein 6
[Homo sapiens]
Length = 1613
Score = 239 bits (610), Expect = 1e-62
Identities = 130/353 (36%), Positives = 199/353 (56%), Gaps = 9/353 (2%)
Query: 443 DNGGCSQLCVPLSPVS--WECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDG 500
DNGGCS LC+ +SPV ++C C G L + K+C G LL A D+R + D
Sbjct: 289 DNGGCSHLCL-MSPVKPFYQCACPTGVKLLENGKTCK-DGATELLLLARRTDLRRISLDT 346
Query: 501 TDYGTLLSQ--QMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPE 558
D+ ++ Q + A+D+DPVE IY+ ++ I R+ +DGS + ++ + P+
Sbjct: 347 PDFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPD 406
Query: 559 GLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTG 618
G+AVDW+ R YWTD G I + LNG KI+ E++ +PR I + PM ++WTD G
Sbjct: 407 GIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWG 466
Query: 619 INPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRR 678
P+IE ++L G R+V+ ++ L WP+G+ +D+ K+YW DAK IE+ N DG+ RR
Sbjct: 467 EIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRV 526
Query: 679 LTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRL-QGSMLKPSSLVVVHPL 737
L ++ + H F + DYV+++DW S+ RV+KR+ + V + Q L VH +
Sbjct: 527 LVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATNVHRV 586
Query: 738 AKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLA 790
G++PC +NGGC H+C R C+C GF SD KTC+ + L +
Sbjct: 587 I--GSNPCAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFS 637
Score = 220 bits (561), Expect = 6e-57
Identities = 116/343 (33%), Positives = 195/343 (56%), Gaps = 9/343 (2%)
Query: 443 DNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTD 502
+NGGCS LC+ P C C G++L D K+C P+ FLLF+ DIR + + T+
Sbjct: 595 ENGGCSHLCL-YRPQGLRCACPIGFELISDMKTCIV--PEAFLLFSRRADIRRISLE-TN 650
Query: 503 YGTLLSQQMGM--VYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGL 560
+ G+ ALD D +N+IY+ +LK I RA M+GS E ++E G+D PEG+
Sbjct: 651 NNNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGM 710
Query: 561 AVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGIN 620
AVDW+G+ YW D G + I S L+G+ +++ +++ PR +A+ P ++WT+ G
Sbjct: 711 AVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGK 770
Query: 621 PRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLT 680
P+I+ +++ G R + ++ +G+TID+ +LYW D ++IE +N+ G R +
Sbjct: 771 PKIDRAAMDGSERTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLG-LNREVI 828
Query: 681 QNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAKP 740
+D+ HPF + ++DY++++DW+ S+ R NK +G++R +QG + ++V H +
Sbjct: 829 ADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQS 888
Query: 741 GADPCLYQNGGCEHIC-KKRLGTAWCSCREGFMKASDGKTCLA 782
G + C NG C H+C +G C C + +D +TC A
Sbjct: 889 GWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSA 931
Score = 200 bits (508), Expect = 8e-51
Identities = 104/327 (31%), Positives = 178/327 (54%), Gaps = 5/327 (1%)
Query: 476 CAASGPQPFLLFANSQDIRHMHF-DGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALK 534
C P LL+AN +D+R + +G + T++ + A+D IY++ + +
Sbjct: 14 CVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEE 73
Query: 535 WIERANMDGSQR-ERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIIT 593
I+R + ++ + ++ G+ P+GLA DW+G + YWTD + I S+L+G K++
Sbjct: 74 AIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLF 133
Query: 594 KENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLT 653
+ + QPR IA+ P + ++WTD G P+IE + + G R +I +S++ WP+G+T+D+
Sbjct: 134 WQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEE 193
Query: 654 DKLYWCDAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKR 713
KLYW DAK + I +NLDG+ R+ + + + HPFA+ +FED ++++DW+ S++ NK
Sbjct: 194 QKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKY 253
Query: 714 TGKDRVRLQGSMLKPSSLVVVHPLAKPGA-DPCLYQNGGCEHICKKRLGTAW--CSCREG 770
TG+ + + P + +P A +PC NGGC H+C + C+C G
Sbjct: 254 TGEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTG 313
Query: 771 FMKASDGKTCLALDGHQLLAGGEVDLK 797
+GKTC LL DL+
Sbjct: 314 VKLLENGKTCKDGATELLLLARRTDLR 340
Score = 154 bits (389), Expect = 5e-37
Identities = 156/622 (25%), Positives = 259/622 (41%), Gaps = 81/622 (13%)
Query: 16 SFVSLSAPQ--HWSCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDA 73
S + L PQ +CP G + TC+ P FL+FS I RI E N +
Sbjct: 600 SHLCLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLT 659
Query: 74 GV--SVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNV-SGMAINWINEEV 130
GV + +DF + RIYW D+ + + R F+NGS E V + GMA++W+ + +
Sbjct: 660 GVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNL 719
Query: 131 IWSNQQEGIITVTDMKGNNSHILL-SALKYPANVAVDPVERFIFWSSEVAG--SLYRADL 187
W++ I V+ + G + +L+ L P +A+DP E F++W +E G + RA +
Sbjct: 720 YWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYW-TEWGGKPKIDRAAM 778
Query: 188 DGVGVKALLETSEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQH 247
DG L+ + +++D +RL+W + +LI S + G + + H
Sbjct: 779 DGSERTTLVPNVGRANGLTIDYAKRRLYWTDLD----TNLIESSNMLGLNREVIADDLPH 834
Query: 248 NLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAE 307
F ++ + D I+++ W ++I ANK +G++ I H +V ++ V H +
Sbjct: 835 P-FGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVM--DILVFH-----SSR 886
Query: 308 DDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGC 367
W C G+CS + +C C Y+L+ D + C ++
Sbjct: 887 QSGWNE----CASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKS 942
Query: 368 TLGC-----KNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCF 422
+ + +P ++LP H L RNV +D PL
Sbjct: 943 AINRMVIDEQQSPD----------IILP----IHSL----RNVRAIDYD-------PL-- 975
Query: 423 CPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKS------C 476
+ + D + + ++G V S S + P YDL +D S C
Sbjct: 976 --DKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQP-YDLSIDIYSRYIYWTC 1032
Query: 477 AASGPQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALK-- 534
A+ I DG G +L + A+ +P + +YF + +
Sbjct: 1033 EATNV-----------INVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSP 1081
Query: 535 WIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITK 594
IERA +DG++RE L G+ P LA+D + +W D I SDL+G ++
Sbjct: 1082 KIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLED 1141
Query: 595 ENISQPRGIAVHPMAKRLFWTD 616
NI QP G+ V L+W D
Sbjct: 1142 SNILQPVGLTV--FENWLYWID 1161
Score = 153 bits (387), Expect = 8e-37
Identities = 100/354 (28%), Positives = 172/354 (48%), Gaps = 15/354 (4%)
Query: 439 CSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHF 498
C+S NG CS LC+ + + C C Y L D ++C+A P FLLF+ I M
Sbjct: 893 CAS-SNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSA--PTTFLLFSQKSAINRMVI 949
Query: 499 DGTDYGTLLS--QQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDV 556
D ++ + V A+D+DP++ ++Y+ + I +A DGSQ ++ V
Sbjct: 950 DEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPS 1009
Query: 557 ------PEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAK 610
P L++D R YWT ++I + L+G+ ++ K +PR + V+P
Sbjct: 1010 QNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKG 1069
Query: 611 RLFWTDTGI-NPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMA 669
+++T+ +P+IE ++L G R V+ S L P + +D KL+W D+ IE +
Sbjct: 1070 YMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESS 1129
Query: 670 NLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPS 729
+L G+ R L +++ P + VFE+++++ D + +++ + R ++Q + + S
Sbjct: 1130 DLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLS 1189
Query: 730 SLVVVHP--LAKPGADPCLYQNGGCEHIC-KKRLGTAWCSCREGFMKASDGKTC 780
+ V L + PC NGGC HIC K GT CSC + D +C
Sbjct: 1190 DIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSC 1243
Score = 94.7 bits (234), Expect = 5e-19
Identities = 77/323 (23%), Positives = 152/323 (47%), Gaps = 28/323 (8%)
Query: 45 APFLIFSHGNSIFRIDTEGTNYEQLVVDAGV--SVIMDFHYNEKRIYWVDLERQLLQRVF 102
AP L++++ + +D +V G+ + +DF ++ IYW D+ + ++R
Sbjct: 20 APLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTE 79
Query: 103 LNGSR--QERVCNIEKNVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILL-SALKY 159
N + Q V + + G+A +W+ E++ W++ + I V+++ G+ +L L
Sbjct: 80 FNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQ 139
Query: 160 PANVAVDPVERFIFWSS--EVAGSLYRADLDGVGVKALLETSEKI--TAVSLDVLDKRLF 215
P +A+DP F++W+ EV + RA +DG + ++ SE ++LD +++L+
Sbjct: 140 PRAIALDPSSGFMYWTDWGEVP-KIERAGMDGSS-RFIIINSEIYWPNGLTLDYEEQKLY 197
Query: 216 WIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKH 275
W + + I + DG + + + FA++LF D ++++ W +I NK+
Sbjct: 198 WA----DAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKY 253
Query: 276 TGKDMVRINLHSS-FVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDL 334
TG+ + I HS F P+ +H +Q + + T C + G CS +
Sbjct: 254 TGEGLREI--HSDIFSPMD----IHAFSQQRQPNAT-----NPCGIDNGGCSHLCLMSPV 302
Query: 335 QS-HLCMCAEGYALSRDRKYCED 356
+ + C C G L + K C+D
Sbjct: 303 KPFYQCACPTGVKLLENGKTCKD 325
Score = 92.4 bits (228), Expect = 2e-18
Identities = 81/338 (23%), Positives = 153/338 (45%), Gaps = 29/338 (8%)
Query: 27 SCPEGT-LAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYEQLVV---DAGVSVIMDFH 82
+CP G L NG + G L+ + + RI + ++ +V+ D ++ +D+
Sbjct: 309 ACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYD 368
Query: 83 YNEKRIYWVDLERQLLQRVFLNGSRQERVCNIE-KNVSGMAINWINEEVIWSNQQEGIIT 141
E IYW D E + ++R F++GS + V + + G+A++W+ + W++ I
Sbjct: 369 PVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIE 428
Query: 142 VTDMKGNNSHILLSA-LKYPANVAVDPVERFIFWS--SEVAGSLYRADLDGVGVKALLET 198
VT + G IL+S L+ P + +DP+ +++W+ E+ + RA LDG L+ T
Sbjct: 429 VTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIP-KIERAALDGSDRVVLVNT 487
Query: 199 S-EKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGD 257
S ++LD + +++W + I + DG + ++F +L GD
Sbjct: 488 SLGWPNGLALDYDEGKIYW----GDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGD 543
Query: 258 RIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPL-AQPKAEDDTWEPEQK 316
++++ W+ ++I +K + + V I+ + L V + + P AE++
Sbjct: 544 YVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATNVHRVIGSNPCAEEN------- 596
Query: 317 LCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYC 354
G CS +C Q C C G+ L D K C
Sbjct: 597 ------GGCSH-LCLYRPQGLRCACPIGFELISDMKTC 627
Score = 68.2 bits (165), Expect = 5e-11
Identities = 95/444 (21%), Positives = 183/444 (41%), Gaps = 51/444 (11%)
Query: 28 CPEGTLAGNGNSTCVGPAPFLIFSHGNSIFR--IDTEGTNYEQLVVDAGVSV-IMDFHYN 84
CP N TC P FL+FS ++I R ID + + L + + +V +D+
Sbjct: 916 CPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPL 975
Query: 85 EKRIYWVDLERQLLQRVFLNGSRQERVC-------NIEKNVSGMAINWINEEVIWSNQQE 137
+K++YW+D + ++++ +GS+ V N+E ++I+ + + W+ +
Sbjct: 976 DKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEAT 1035
Query: 138 GIITVTDMKGNNSHILLSALK-YPANVAVDPVERFIFWSS--EVAGSLYRADLDGVGVKA 194
+I VT + G + ++L + P V V+P + ++++++ E + + RA LDG +
Sbjct: 1036 NVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREV 1095
Query: 195 LLETS-EKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMS 253
L + K A++LD +LFW + I S D G + + + ++
Sbjct: 1096 LFFSGLSKPIALALDSRLGKLFW----ADSDLRRIESSDLSGANRIVLEDSNILQPVGLT 1151
Query: 254 LFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEP 313
+F + +++ + + I + TG++ R + + L ++ V L + E
Sbjct: 1152 VFENWLYWIDKQQQMIEKIDM-TGRE-GRTKVQARIAQLSDIHAVKEL-------NLQEY 1202
Query: 314 EQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKN 373
Q C G CS + + C C L +D C + C
Sbjct: 1203 RQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTC------------- 1249
Query: 374 TPGSYYCTCPVGFV-LLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERD 432
+P + TC G + +P RC C + E +C + SE C G ++
Sbjct: 1250 SPQQF--TCFTGEIDCIPVAWRCDGFTECEDHSDEL--NCPVCSESQF-QCASGQCID-G 1303
Query: 433 GKTCSGCSS----PDNGGCSQLCV 452
C+G ++ D C LC+
Sbjct: 1304 ALRCNGDANCQDKSDEKNCEVLCL 1327
Score = 43.5 bits (101), Expect = 0.001
Identities = 26/87 (29%), Positives = 37/87 (42%), Gaps = 3/87 (3%)
Query: 401 CPRNVSECSHDCVLTSEGPL-CFCPEGSVLERDGKTCSG--CSSPDNGGCSQLCVPLSPV 457
C ++ CSH C++ +G C CP VL +D +C SP C + PV
Sbjct: 1207 CAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPV 1266
Query: 458 SWECDCFPGYDLQLDEKSCAASGPQPF 484
+W CD F + DE +C F
Sbjct: 1267 AWRCDGFTECEDHSDELNCPVCSESQF 1293
>gi|66082554 low density lipoprotein receptor-related protein 8
isoform 2 precursor [Homo sapiens]
Length = 793
Score = 239 bits (610), Expect = 1e-62
Identities = 139/403 (34%), Positives = 211/403 (52%), Gaps = 25/403 (6%)
Query: 398 LVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSG---CSSPDNGGCSQLCVPL 454
L C N CSH C G C CP G L D KTC C PD CSQ+CV
Sbjct: 167 LNECLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGDIDECKDPD--ACSQICVNY 223
Query: 455 SPVSWECDCFPGYDLQLDEKSC-AASGPQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGM 513
++C+C+PGY++ L K+C AA+G P L+F N ++R + +Y L+ +
Sbjct: 224 KGY-FKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNV 282
Query: 514 VYALDHDPVENKIYFAHTALKWIERANMDGS----QRERLIEEGVDVPEGLAVDWIGRRF 569
V ALD + N+IY+ + + I A MD + ++E LI+E + PEGLAVDW+ +
Sbjct: 283 V-ALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 341
Query: 570 YWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQ 629
YWTD G I + ++G R + + N+S+PR IAV P+ ++W+D G +IE S L
Sbjct: 342 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 401
Query: 630 GLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQND--VGHP 687
G+ R + S ++ WP+GIT+D L+ +LYW D+K + + G R+ L + + HP
Sbjct: 402 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHP 461
Query: 688 FAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAKPGA-DPC- 745
F +AVFED V+++D ++ N+ G + L ++ P +V+ H L +P A D C
Sbjct: 462 FGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACE 521
Query: 746 --LYQNGGCEHIC------KKRLGTAWCSCREGFMKASDGKTC 780
+ NGGCE++C C+C + D K C
Sbjct: 522 LSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 564
Score = 107 bits (268), Expect = 5e-23
Identities = 100/428 (23%), Positives = 189/428 (44%), Gaps = 66/428 (15%)
Query: 43 GPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVF 102
G +P LIF++ + + RID NY +L+ V +D RIYW DL + + +
Sbjct: 249 GKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAY 308
Query: 103 LNGS---RQERVCNIEK--NVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSA- 156
++ + +++ V E+ + G+A++W+++ + W++ I+V + G L S
Sbjct: 309 MDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRN 368
Query: 157 LKYPANVAVDPVERFIFWSS-EVAGSLYRADLDGVGVKALL-ETSEKITAVSLDVLDKRL 214
L P +AVDP+ F++WS + ++ L+GV + L+ + E ++LD+L +RL
Sbjct: 369 LSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRL 428
Query: 215 FWIQYNREGSNSLICSCDYDGGS--VHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIA 272
+W+ + + S D+ GG+ IS + F +++F D++F++ + + I+ A
Sbjct: 429 YWV----DSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSA 484
Query: 273 NKHTGKD--MVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVC 330
N+ G + ++ NL++ ++ + H L QP+A D +L G C
Sbjct: 485 NRLNGLEISILAENLNNPH----DIVIFHELKQPRAPDAC-----ELSVQPNGGC----- 530
Query: 331 GQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLP 390
+LC+ A + ++P Y C CP L P
Sbjct: 531 -----EYLCLPAPQIS-------------------------SHSP-KYTCACPDTMWLGP 559
Query: 391 DGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDNGGC--S 448
D KRC++ P++ S + +T P G+ + R +P S
Sbjct: 560 DMKRCYR---APQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPS 616
Query: 449 QLCVPLSP 456
+ VP +P
Sbjct: 617 SVSVPRAP 624
Score = 41.6 bits (96), Expect = 0.005
Identities = 27/70 (38%), Positives = 35/70 (50%), Gaps = 9/70 (12%)
Query: 839 GCSMYARCISEGEDATCQCLKGFAG-DGKLCSDIDECEMGVPVCPPASSK-CINTEGGYV 896
GCS + G + TC GF D K C DIDEC+ P A S+ C+N +G +
Sbjct: 176 GCSHICTDLKIGFECTCPA--GFQLLDQKTCGDIDECKD-----PDACSQICVNYKGYFK 228
Query: 897 CRCSEGYQGD 906
C C GY+ D
Sbjct: 229 CECYPGYEMD 238
>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
Length = 4655
Score = 234 bits (596), Expect = 5e-61
Identities = 189/678 (27%), Positives = 294/678 (43%), Gaps = 84/678 (12%)
Query: 332 QDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPD 391
Q Q + C G +S+ C++ N+C + C +TP TCP +
Sbjct: 3030 QTCQQNQFTCQNGRCISKTF-VCDEDNDCGDGSDELMHLC-HTPEP---TCPPHEFKCDN 3084
Query: 392 G------KRCHQLVSCPRN---------------VSECSHDCVLTSEGPLCFCPEGSVLE 430
G K C+ L C N +S C H+C T C C G L
Sbjct: 3085 GRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLM 3144
Query: 431 RDGKTCSGCSSPDNGG--CSQLCVPLSPVSWECDCFPGYDLQLDEKSCAA-SGPQPFLLF 487
D +TC CSQ C + S+ C C PGY + D K+C S +P+L+F
Sbjct: 3145 SDKRTCVDIDECTEMPFVCSQKCENVIG-SYICKCAPGYLREPDGKTCRQNSNIEPYLIF 3203
Query: 488 ANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRE 547
+N +R++ DG Y +L + + V ALD D VE ++Y+ T + IER ++ + +E
Sbjct: 3204 SNRYYLRNLTIDGYFYSLIL-EGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKE 3262
Query: 548 RLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENIS--------Q 599
+I + E LAVDW+ R+ YW D + SDLNG +++ + +
Sbjct: 3263 TIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDN 3322
Query: 600 PRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWC 659
PRG+A+HP L+W D G I + G + VI S+ L WP+GITID+ D LYW
Sbjct: 3323 PRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWA 3382
Query: 660 DAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRV 719
DA IE ++L+G R + + HPFA+ +FED ++++DW +V + NK G +R
Sbjct: 3383 DAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQ 3442
Query: 720 RLQGSMLKPSSLVVVHPLAKP-GADPCLYQNGGCEHICKKRLGTA--WCSCREGF--MKA 774
L + +P + V HP +P ++PC NGGC H+C + G C C + F ++
Sbjct: 3443 TLVNTTHRPFDIHVYHPYRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQL 3502
Query: 775 SDGKTCLAL---------------------DGHQLLAGGEVDLKNQVTPLDILSKTRVSE 813
S C+ + DG + + G +L L + + S+
Sbjct: 3503 SGSTYCMPMCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSD 3562
Query: 814 DNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQCLK-----GFAGDGKLC 868
N T Q + A D D + C + +E + A +C+ D +
Sbjct: 3563 GNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQCDTFNDCEDN 3622
Query: 869 SDIDECEMGVPVCPPASSKCINTEGGYVCRC-SEGYQGD-----GIHCLD-IDECQLGEH 921
SD D C P +C N RC + ++ D G H + I+EC H
Sbjct: 3623 SDEDSSHCASRTCRPGQFRCANG------RCIPQAWKCDVDNDCGDHSDEPIEECMSSAH 3676
Query: 922 SCGENASCTNTEGGYTCM 939
C +N + + + Y C+
Sbjct: 3677 LC-DNFTEFSCKTNYRCI 3693
Score = 205 bits (522), Expect = 2e-52
Identities = 122/396 (30%), Positives = 198/396 (50%), Gaps = 14/396 (3%)
Query: 400 SCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDN-GGCSQLCVPLSPVS 458
SC C+H+CV G C CP G +L D KTC D G CSQ C + S
Sbjct: 1352 SCSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQHCYNMRG-S 1410
Query: 459 WECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDYGTLLS--QQMGMVYA 516
+ C C GY L+ D ++C + + LL SQ+ + + S + + A
Sbjct: 1411 FRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKIIADSVTSQVHNIYSLVENGSYIVA 1470
Query: 517 LDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGK 576
+D D + +I+++ A +G+ R + + + + E +A+DW+GR YWTD
Sbjct: 1471 VDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAIDWVGRNLYWTDYAL 1530
Query: 577 SLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKR--LFWTDTGINPRIESSSLQGLGRL 634
I S ++G ++ +N++ PRG+A+ P LFW+D G +PRIE +S+ G R
Sbjct: 1531 ETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASMDGSMRT 1590
Query: 635 VIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQND--VGHPFAVAV 692
VI + WP G+TID+ LY+ D+ ++ + +G RR++ +D + HP+A+ +
Sbjct: 1591 VIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPYALTL 1650
Query: 693 FEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAKPGA-DPCLYQNGG 751
FED V+++D A VMR NK G ++ + ++ P +V VHP +P + +PC +
Sbjct: 1651 FEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCAFSR-- 1708
Query: 752 CEHIC-KKRLGTAW--CSCREGFMKASDGKTCLALD 784
C H+C G + C C G+ + D CL D
Sbjct: 1709 CSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNCLRDD 1744
Score = 187 bits (476), Expect = 4e-47
Identities = 132/501 (26%), Positives = 223/501 (44%), Gaps = 52/501 (10%)
Query: 325 CSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYY----- 379
C+ CG + C G + ++ C+ ++C ++G GC++ P +
Sbjct: 217 CNYPTCG----GYQFTCPSGRCIYQNW-VCDGEDDCK--DNGDEDGCESGPHDVHKCSPR 269
Query: 380 -CTCPVGFVLLPDGKRCHQLVSCPRNVSE------------------CSHDCVLTSEGPL 420
+CP + K C ++ CP E C + C T G
Sbjct: 270 EWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMTLCSALNCQYQCHETPYGGA 329
Query: 421 CFCPEGSVLER-DGKTCSGCSSPDNGG-CSQLCVPLSPVSWECDCFPGYDLQLDEKSCAA 478
CFCP G ++ D +TC G C Q C P C C GY L+ + C A
Sbjct: 330 CFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCES-RPGRHLCHCEEGYILERGQY-CKA 387
Query: 479 SGP--QPFLLFANSQDIRHMHFDGTDYGTLL-SQQMGMVYALDHDPVENKIYFAHTALKW 535
+ + ++F+N +D+ G + L+ SQ G+ + ++++ T
Sbjct: 388 NDSFGEASIIFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNK 447
Query: 536 IERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKE 595
+ +++G + ++ V+ PE LAVDW+ + Y + + I +L+G + E
Sbjct: 448 VFSVDINGLNIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITE 507
Query: 596 NISQPRGIAVHPMAKRLF---WTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFL 652
N+ PRGIAV P LF W P++E + + G R + + L WP+G+T+D +
Sbjct: 508 NLGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMI 567
Query: 653 TDKLYWCDAKQSVIEMANLDGSKRRRLTQND--VGHPFAVAVFEDYVWFSDWAMPSVMRV 710
+ ++YW D++ IE DG +R+ + + HPF V++FE V+F+DW +V++
Sbjct: 568 SKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKA 627
Query: 711 NKRTGKDRVRLQGSMLKPSSLVVVHPLAKPGA-DPCLYQNGGCEHIC-------KKRLGT 762
NK T + + L+P + V H L +P A +PC NGGCE +C LG
Sbjct: 628 NKFTETNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDNNGGCEQVCVLSHRTDNDGLGF 687
Query: 763 AWCSCREGFMKASDGKTCLAL 783
C C GF +D + C+A+
Sbjct: 688 R-CKCTFGFQLDTDERHCIAV 707
Score = 170 bits (431), Expect = 7e-42
Identities = 112/356 (31%), Positives = 178/356 (50%), Gaps = 16/356 (4%)
Query: 443 DNGGCSQLCVPLSPVSW-ECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGT 501
+NGGCS LC L + +CDC G LQ D K+CA S + FL+FA S +R +H D
Sbjct: 2349 NNGGCSHLCFALPGLHTPKCDCAFG-TLQSDGKNCAIS-TENFLIFALSNSLRSLHLDPE 2406
Query: 502 DYGTLLS--QQMGMVYALDHDPVENKIYFAHTALKWIERANM----DGSQRERLIEEGVD 555
++ V +LD+D V ++IYF + + + G +I G+
Sbjct: 2407 NHSPPFQTINVERTVMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIG 2466
Query: 556 VPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWT 615
+G+A DWI RR Y++D +I +G +I + + +PR I + P L+W
Sbjct: 2467 TADGIAFDWITRRIYYSDYLNQMINSMAEDGSNRTVIAR--VPKPRAIVLDPCQGYLYWA 2524
Query: 616 DTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSK 675
D + +IE ++L G R+ I +S L+ PSG+T+D+ D LYW DA IE + L G
Sbjct: 2525 DWDTHAKIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVD 2584
Query: 676 RRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSML-KPSSL-VV 733
R + N H F + ++ Y++++D + R NK G ++ + ++L +P + V
Sbjct: 2585 REVIV-NAAVHAFGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTV 2643
Query: 734 VHPLAKPGADPCLYQNGGCEHICKKRLGTAWCSC-REG-FMKASDGKTCLALDGHQ 787
V + +PC NGGC HIC A C C EG + A++ K C+ +G +
Sbjct: 2644 VKNQKQQCNNPCEQFNGGCSHICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGER 2699
Score = 166 bits (421), Expect = 9e-41
Identities = 131/460 (28%), Positives = 215/460 (46%), Gaps = 68/460 (14%)
Query: 341 CAEGYALSRDRKYCEDVNECAFWNH--GCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQL 398
C G+ + D C+D ++C W+ GC G + T
Sbjct: 3935 CGNGHCIPHDN-VCDDADDCGDWSDELGCNKGKERT------------------------ 3969
Query: 399 VSCPRNVSECSHDCVLTSEGP-LCFCPEG---SVLERDGKTCSGCSSPDN-GGCSQLCVP 453
C N+ C +C +EG +C C G +V +R +C + + G C Q C
Sbjct: 3970 --CAENI--CEQNCTQLNEGGFICSCTAGFETNVFDRT--SCLDINECEQFGTCPQHCRN 4023
Query: 454 LSPVSWECDCFPGYDLQLDE--KSCAASGPQPFLLFANSQDIRHMHFDGTDYGTLLSQQM 511
S+EC C G+ D K CAA G P LL ++ IR + + L Q
Sbjct: 4024 TKG-SYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSERFSEYL-QDE 4081
Query: 512 GMVYALDHD--PVENKIYFAHTALKW-------IERANMDG--SQRERLIEEGVDV---- 556
+ A+D+D P + + + ++ I+RA + S R L++E VD+
Sbjct: 4082 EYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQE-VDLKLKY 4140
Query: 557 ---PEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLF 613
P+G+AVDW+GR YW+D I + L+G+ K + ++ QP IAV+P +F
Sbjct: 4141 VMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMF 4200
Query: 614 WTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFL-TDKLYWCDAKQSVIEMANLD 672
WTD G P+IES+ + G R ++ DL WP+G++ID+L D++YW D K+ VIE D
Sbjct: 4201 WTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYD 4260
Query: 673 GSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNK--RTGKDRVRLQGSMLKPSS 730
G+ RR + + + +P+++ +FED +++ V + NK + K++ + L +
Sbjct: 4261 GTDRRVIAK-EAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWL--TQ 4317
Query: 731 LVVVHPLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREG 770
+ + H L + P L + C H+C R G C+C +G
Sbjct: 4318 VRIFHQLRYNKSVPNLCKQ-ICSHLCLLRPGGYSCACPQG 4356
Score = 164 bits (416), Expect = 4e-40
Identities = 107/351 (30%), Positives = 168/351 (47%), Gaps = 16/351 (4%)
Query: 443 DNGGCSQLCV-----PLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMH 497
+NGGC Q+CV + + C C G+ L DE+ C A Q FL+F++ IR +
Sbjct: 666 NNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAV--QNFLIFSSQVAIRGIP 723
Query: 498 FDGT---DYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGV 554
F + D +S +D D ++ I+F+ + I + +DG+ RE L V
Sbjct: 724 FTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTGREILAANRV 783
Query: 555 DVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFW 614
+ E LA DWI + YWTD I L K + + + ++ PR + VHP A LF+
Sbjct: 784 ENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVV-QYLNNPRSVVVHPFAGYLFF 842
Query: 615 TDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGS 674
TD +I + G L + ++ L WP+G+ ID+ +LYW DA IE + DG
Sbjct: 843 TDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGL 902
Query: 675 KRRRLTQ-NDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVV 733
RRRL + HPF +A+F ++++F+DW + +++RV K G + ++ + L
Sbjct: 903 DRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKS 962
Query: 734 VHPLAKPGADPC---LYQNGGCEHICKKRLG-TAWCSCREGFMKASDGKTC 780
+ G++ C + NG C H C C C G AS+ TC
Sbjct: 963 YDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTC 1013
Score = 130 bits (328), Expect = 6e-30
Identities = 96/370 (25%), Positives = 160/370 (43%), Gaps = 27/370 (7%)
Query: 434 KTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDI 493
++ +GCS+ N C Q+C+P+ + C C G+ L D +SC S F++ + I
Sbjct: 2017 ESSNGCSNNMNA-CQQICLPVPGGLFSCACATGFKLNPDNRSC--SPYNSFIVVSMLSAI 2073
Query: 494 RHMHFDGTDYGTLLSQQMGM---VYALDHDPVENKIYFAHTALKW-----IERANMDGSQ 545
R + +D+ + G +D D IY+ + I R DGS
Sbjct: 2074 RGFSLELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASDNAIRRIKPDGSS 2133
Query: 546 RERLIEEGV--DVPEGLAVDWIGRRFYWTDR--GKSLIGRSDLNGKRSKIITKENISQPR 601
++ G+ + G+AVDW+ Y+T+ ++LI +N +++ K + PR
Sbjct: 2134 LMNIVTHGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPR 2193
Query: 602 GIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDA 661
I V P + LFW D G P+IE S L R V+ S ++ P G+ +D +YW D
Sbjct: 2194 HIVVDPKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDD 2253
Query: 662 KQSVIEMANLDGSKRRRLTQND-VGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTG----- 715
+I ++G + P+ + VFE+ + + D + + + +K
Sbjct: 2254 SLDIIARIRINGENSEVIRYGSRYPTPYGITVFENSIIWVDRNLKKIFQASKEPENTEPP 2313
Query: 716 ---KDRVRLQGSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHIC--KKRLGTAWCSCREG 770
+D + + V A+ +PCL NGGC H+C L T C C G
Sbjct: 2314 TVIRDNINWLRDVTIFDKQVQPRSPAEVNNNPCLENNGGCSHLCFALPGLHTPKCDCAFG 2373
Query: 771 FMKASDGKTC 780
++ SDGK C
Sbjct: 2374 TLQ-SDGKNC 2382
Score = 127 bits (318), Expect = 8e-29
Identities = 156/660 (23%), Positives = 257/660 (38%), Gaps = 84/660 (12%)
Query: 148 NNSHILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALLETSEKIT-AVS 206
+N + L+ Y V D + IFWS G + A +G + + ++S +T ++
Sbjct: 1456 HNIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIA 1515
Query: 207 LDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMS--LFGDRIFYSTW 264
+D + + L+W Y E + D +V ISK+ T A+ + +F+S W
Sbjct: 1516 IDWVGRNLYWTDYALETIE--VSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDW 1573
Query: 265 KMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGN 324
G I F P G L + +P + D++ C G+
Sbjct: 1574 GHHPRIERASMDGSMRTVIVQDKIFWPCG-LTIDYP-NRLLYFMDSYLDYMDFCDYN-GH 1630
Query: 325 CSSTVCGQDLQSHLCMCAEGYALS--RDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTC 382
V DL + YAL+ D Y D G + Y
Sbjct: 1631 HRRQVIASDL-----IIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQW 1685
Query: 383 PVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSP 442
P+G V + K+ + + C S CSH C+L+S+G
Sbjct: 1686 PLGIVAVHPSKQPNSVNPCA--FSRCSHLCLLSSQG------------------------ 1719
Query: 443 DNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTD 502
P + C C G+ L D +C QPFL+ +H+ F G
Sbjct: 1720 -------------PHFYSCVCPSGWSLSPDLLNCLRDD-QPFLITVR----QHIIF-GIS 1760
Query: 503 YGTLLSQQMGMV--------YALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGV 554
+ MV ++ D E IY+ + I R DG+ R +
Sbjct: 1761 LNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVENPGE-IHRVKTDGTNRTVFASISM 1819
Query: 555 DVPE-GLAVDWIGRRFYWTDRGKSLIGRSDLNGK---RSKIITKEN----ISQPRGIAVH 606
P LA+DWI R Y T+ I L+G R +I + + P GI V
Sbjct: 1820 VGPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVD 1879
Query: 607 PMAKRLFW----TDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAK 662
P +L+W TD+G+ +I S+++ G + + +L +T+D KLYW
Sbjct: 1880 PARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTG 1939
Query: 663 QSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQ 722
+ VIE N+DG+ R L + + HP+ +AV + +++++D + RV+K TG +++ L+
Sbjct: 1940 RGVIERGNVDGTDRMILV-HQLSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLR 1998
Query: 723 GSMLKPSSLVVVHPL-AKPGADPCLYQNGGCEHICKKRLGTAW-CSCREGFMKASDGKTC 780
++ L V H A ++ C C+ IC G + C+C GF D ++C
Sbjct: 1999 DNVPNLRGLQVYHRRNAAESSNGCSNNMNACQQICLPVPGGLFSCACATGFKLNPDNRSC 2058
Score = 117 bits (293), Expect = 7e-26
Identities = 119/499 (23%), Positives = 208/499 (41%), Gaps = 65/499 (13%)
Query: 16 SFVSLSAPQHWSCPEG-TLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAG 74
S++ AP + P+G T N N P+LIFS+ + + +G Y ++
Sbjct: 3173 SYICKCAPGYLREPDGKTCRQNSNIE-----PYLIFSNRYYLRNLTIDGYFYSLILEGLD 3227
Query: 75 VSVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIE-KNVSGMAINWINEEVIWS 133
V +DF EKR+YW+D +RQ+++R+FLN + +E + N +A++W++ ++ W
Sbjct: 3228 NVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWL 3287
Query: 134 NQQEGIITVTDMKGNNSHILLS---------ALKYPANVAVDPVERFIFWSS-EVAGSLY 183
+ + + V+D+ G + +L P +A+ P +++W+ +
Sbjct: 3288 DARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIG 3347
Query: 184 RADLDGVGVKALLETS-EKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISK 242
R +DG ++ T E +++D + L+W + I D +G H
Sbjct: 3348 RVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYW----ADAHLGYIEYSDLEGHHRHTVY 3403
Query: 243 HPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRI--NLHSSFVPLGELKVVHP 300
+ FA+++F D I+++ W +T+ NK+ G + + H F ++ V HP
Sbjct: 3404 DGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPF----DIHVYHP 3459
Query: 301 LAQPKAEDDTWEPEQKLCKLRKGNCSS-TVCGQDLQSHLCMCAEGYALSR--DRKYCEDV 357
QP + C G CS + + C C + + + YC +
Sbjct: 3460 YRQPIVSNP--------CGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPM 3511
Query: 358 NECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVS-----ECSHDC 412
C+ C K P + C G DG +L CP+ +CS D
Sbjct: 3512 --CSSTQFLCANNEKCIPIWWKCD---GQKDCSDGS--DELALCPQRFCRLGQFQCS-DG 3563
Query: 413 VLTSEGPLC----FCPEGSVLERDGKTCSG--CSSPDNGGCSQLCVPLSPVSWECDCFPG 466
TS LC CP+GS + D C C S + ++ C+ P SW+CD F
Sbjct: 3564 NCTSPQTLCNAHQNCPDGS--DEDRLLCENHHCDSNEWQCANKRCI---PESWQCDTFND 3618
Query: 467 YDLQLDEKS--CAASGPQP 483
+ DE S CA+ +P
Sbjct: 3619 CEDNSDEDSSHCASRTCRP 3637
Score = 109 bits (273), Expect = 1e-23
Identities = 98/353 (27%), Positives = 164/353 (46%), Gaps = 47/353 (13%)
Query: 28 CPEGTLAGNGNSTCVGPAPF----LIFSHGNSIFRIDTEGTNYEQLVV--DAGVSVIMDF 81
C EG + G C F +IFS+G + D G ++ LV + GV+V + F
Sbjct: 373 CEEGYILERGQY-CKANDSFGEASIIFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVAF 431
Query: 82 HYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIE-KNVSGMAINWINEEVIWSNQQEGII 140
HY+ +R++W D + + V +NG + V N+ + +A++W+N ++ + I
Sbjct: 432 HYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRI 491
Query: 141 TVTDMKGNNSHILLSA-LKYPANVAVDPVERFIFWS--SEVAG--SLYRADLDGVGVKAL 195
+ ++ G+ L++ L +P +AVDP ++F+S ++G L RA +DG K L
Sbjct: 492 DMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDL 551
Query: 196 LETSEKITA-VSLDVLDKRLFWIQYNREGSNSLICSCDYDG----GSVH---ISKHPTQH 247
++T A V+LD++ KR++W+ + I + YDG VH + HP
Sbjct: 552 VKTKLGWPAGVTLDMISKRVYWV----DSRFDYIETVTYDGIQRKTVVHGGSLIPHP--- 604
Query: 248 NLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAE 307
F +SLF ++F++ W + ANK T + ++ +S P G + V H L QP A
Sbjct: 605 --FGVSLFEGQVFFTDWTKMAVLKANKFT-ETNPQVYYQASLRPYG-VTVYHSLRQPYAT 660
Query: 308 DDTWEPEQKLCKLRKGNCSSTVC------GQDLQSHLCMCAEGYALSRDRKYC 354
+ CK G C VC D C C G+ L D ++C
Sbjct: 661 NP--------CKDNNGGCEQ-VCVLSHRTDNDGLGFRCKCTFGFQLDTDERHC 704
Score = 74.3 bits (181), Expect = 6e-13
Identities = 77/376 (20%), Positives = 150/376 (39%), Gaps = 44/376 (11%)
Query: 28 CPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGVS----VIMDFHY 83
C G C+ FLIFS +I I + E ++V + V +DF
Sbjct: 691 CTFGFQLDTDERHCIAVQNFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDA 750
Query: 84 NEKRIYWVDLERQLLQRVFLNGSRQERVC-NIEKNVSGMAINWINEEVIWSNQQEGIITV 142
+ I++ D+ + ++ + ++G+ +E + N +NV +A +WI++ + W++ I+V
Sbjct: 751 QDSTIFFSDMSKHMIFKQKIDGTGREILAANRVENVESLAFDWISKNLYWTDSHYKSISV 810
Query: 143 TDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEV-AGSLYRADLDGVGVKALLETS-E 200
+ ++ L P +V V P ++F++ + RA DG + ++ T+
Sbjct: 811 MRLADKTRRTVVQYLNNPRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLG 870
Query: 201 KITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDG------GSVHISKHPTQHNLFAMSL 254
+++D RL+W+ + I +DG G + HP F +++
Sbjct: 871 WPNGLAIDWAASRLYWV----DAYFDKIEHSTFDGLDRRRLGHIEQMTHP-----FGLAI 921
Query: 255 FGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPE 314
FG+ +F++ W++ I K G +M I +++ K+ D +
Sbjct: 922 FGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYI-----------LHLKSYDVNIQTG 970
Query: 315 QKLCKL---RKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCE-------DVNECAFWN 364
C G+CS +C C G L+ + CE +C ++
Sbjct: 971 SNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTCEGDPTNEPPTEQCGLFS 1030
Query: 365 HGCTLGCKNTPGSYYC 380
C G + P Y C
Sbjct: 1031 FPCKNG-RCVPNYYLC 1045
Score = 66.2 bits (160), Expect = 2e-10
Identities = 99/476 (20%), Positives = 175/476 (36%), Gaps = 72/476 (15%)
Query: 15 FSFVSLSAPQHWSCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYE---QLVV 71
F+ L P+ C GTL +G + + FLIF+ NS+ + + N+ Q +
Sbjct: 2358 FALPGLHTPK-CDCAFGTLQSDGKNCAISTENFLIFALSNSLRSLHLDPENHSPPFQTIN 2416
Query: 72 DAGVSVIMDFHYNEKRIYWVDL----ERQLLQRVFLNGSRQERV-CNIEKNVSGMAINWI 126
+ +D+ RIY+ Q+ +G V + G+A +WI
Sbjct: 2417 VERTVMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWI 2476
Query: 127 NEEVIWSNQQEGIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSS-EVAGSLYRA 185
+ +S+ +I G+N ++ K P + +DP + +++W+ + + RA
Sbjct: 2477 TRRIYYSDYLNQMINSMAEDGSNRTVIARVPK-PRAIVLDPCQGYLYWADWDTHAKIERA 2535
Query: 186 DLDGVGVKALLETSEKI-TAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHP 244
L G ++ +S + + ++LD + L+W+ + S I G + +
Sbjct: 2536 TLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWV----DASLQRIERSTLTGVDREVIVNA 2591
Query: 245 TQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQP 304
H F ++L+G I+++ + I+ ANK+ G + + + P G VV Q
Sbjct: 2592 AVH-AFGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQ 2650
Query: 305 KAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAE--GYALSRDRKYC--EDVNEC 360
C+ G CS +C C C + L+ +RK+C ++ C
Sbjct: 2651 C---------NNPCEQFNGGCSH-ICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGERC 2700
Query: 361 AFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPL 420
G+ TC G + + K C C E C L + P
Sbjct: 2701 ---------------GASSFTCSNGRCISEEWK-CDNDNDCGDGSDEMESVCALHTCSPT 2744
Query: 421 CFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
F TC+ NG C Q S+ CD + DE C
Sbjct: 2745 AF------------TCA------NGRCVQ-------YSYRCDYYNDCGDGSDEAGC 2775
Score = 66.2 bits (160), Expect = 2e-10
Identities = 28/68 (41%), Positives = 36/68 (52%)
Query: 330 CGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLL 389
C L S C C GY L D++ C D++EC C+ C+N GSY C C G++
Sbjct: 3126 CTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAPGYLRE 3185
Query: 390 PDGKRCHQ 397
PDGK C Q
Sbjct: 3186 PDGKTCRQ 3193
Score = 57.0 bits (136), Expect = 1e-07
Identities = 73/329 (22%), Positives = 128/329 (38%), Gaps = 76/329 (23%)
Query: 120 GMAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSA-LKYPANVAVDPVERFIFWSS-E 177
G+A++W+ + WS+ + I V + G L+S L PA +AV+P +FW+
Sbjct: 4146 GIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWG 4205
Query: 178 VAGSLYRADLDGVGVKALL-ETSEKITAVSLDVLDK-RLFWIQYNREGSNSLICSCDYDG 235
+ A ++G L+ E T +S+D L+ R++W + + +I + YDG
Sbjct: 4206 KEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKED----VIETIKYDG 4261
Query: 236 GSVHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKH-TGKDMVRINLHSSFVPLGE 294
+ N +++ +F D++++ + + +W NK GK + ++ L +
Sbjct: 4262 TDRRVIAKEAM-NPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPW---LTQ 4317
Query: 295 LKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYC 354
+++ H L K+ + LCK +C SHLC+
Sbjct: 4318 VRIFHQLRYNKSVPN-------LCK--------QIC-----SHLCLL------------- 4344
Query: 355 EDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDG-KRCHQLVSCPRNV---SECSH 410
PG Y C CP G + C + P N+ C H
Sbjct: 4345 -------------------RPGGYSCACPQGSSFIEGSTTECDAAIELPINLPPPCRCMH 4385
Query: 411 --DCVL-TSEGPLCFCPEGSVLERDGKTC 436
+C ++ P C CP G GK C
Sbjct: 4386 GGNCYFDETDLPKCKCPSGYT----GKYC 4410
Score = 54.3 bits (129), Expect = 7e-07
Identities = 74/352 (21%), Positives = 144/352 (40%), Gaps = 37/352 (10%)
Query: 27 SCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGV----SVIMDFH 82
+C G N +C F++ S ++I E +++ + +V ++ +D
Sbjct: 2044 ACATGFKLNPDNRSCSPYNSFIVVSMLSAIRGFSLELSDHSETMVPVAGQGRNALHVDVD 2103
Query: 83 YNEKRIYWVDLERQL-----LQRVFLNGSRQERVCNI---EKNVSGMAINWINEEVIWSN 134
+ IYW D + ++R+ +GS + E V G+A++W+ + ++N
Sbjct: 2104 VSSGFIYWCDFSSSVASDNAIRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLYFTN 2163
Query: 135 Q--QEGIITVTDMKGNNSHILLSA-LKYPANVAVDPVERFIFWSS-EVAGSLYRADLDGV 190
E +I V + +LL + P ++ VDP R++FW+ + R+ LD
Sbjct: 2164 AFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPKNRYLFWADYGQRPKIERSFLDCT 2223
Query: 191 GVKALLETSEKIT---AVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHI----SKH 243
L+ SE I +++D D ++W+ + S +I +G + + S++
Sbjct: 2224 NRTVLV--SEGIVTPRGLAVDRSDGYVYWV----DDSLDIIARIRINGENSEVIRYGSRY 2277
Query: 244 PTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQ 303
PT + +++F + I + +K I+ A+K + + L ++ + Q
Sbjct: 2278 PTP---YGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVIRDNINWLRDVTIFDKQVQ 2334
Query: 304 PKAEDDTWEPEQKLCKLRKGNCSSTVCG-QDLQSHLCMCAEGYALSRDRKYC 354
P++ E C G CS L + C CA G L D K C
Sbjct: 2335 PRSPA---EVNNNPCLENNGGCSHLCFALPGLHTPKCDCAFG-TLQSDGKNC 2382
Score = 53.1 bits (126), Expect = 2e-06
Identities = 44/135 (32%), Positives = 58/135 (42%), Gaps = 26/135 (19%)
Query: 866 KLCSDIDEC------------EMGVPVCPPASSKCINTEGGYVCRCSEGYQ--GDGIHCL 911
KLC+ +D+C E P C +T + C C GY+ D C+
Sbjct: 3092 KLCNHLDDCLDNSDEKGCGINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCV 3151
Query: 912 DIDECQLGEHSCGENASCTNTEGGYTCMCA-GRLSEP-GLIC-PDSTPPPHLREDDHHYS 968
DIDEC C + C N G Y C CA G L EP G C +S P+L + +Y
Sbjct: 3152 DIDECTEMPFVCSQK--CENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYY- 3208
Query: 969 VRNSDSECPLSHDGY 983
+RN L+ DGY
Sbjct: 3209 LRN------LTIDGY 3217
Score = 50.8 bits (120), Expect = 8e-06
Identities = 29/76 (38%), Positives = 35/76 (46%), Gaps = 10/76 (13%)
Query: 839 GCSMYARCISEGEDATCQCLKGF--AGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYV 896
GC+ C+ E A C C GF A D K C DIDEC+ + S C N G +
Sbjct: 1359 GCTH--ECVQEPFGAKCLCPLGFLLANDSKTCEDIDECD----ILGSCSQHCYNMRGSFR 1412
Query: 897 CRCSEGY--QGDGIHC 910
C C GY + DG C
Sbjct: 1413 CSCDTGYMLESDGRTC 1428
Score = 49.3 bits (116), Expect = 2e-05
Identities = 30/82 (36%), Positives = 43/82 (52%), Gaps = 12/82 (14%)
Query: 892 EGGYVCRCSEGYQG---DGIHCLDIDEC-QLGEHSCGENASCTNTEGGYTCMCAGRLS-- 945
EGG++C C+ G++ D CLDI+EC Q G +C ++ C NT+G Y C+CA +
Sbjct: 3984 EGGFICSCTAGFETNVFDRTSCLDINECEQFG--TCPQH--CRNTKGSYECVCADGFTSM 4039
Query: 946 --EPGLICPDSTPPPHLREDDH 965
PG C P L D+
Sbjct: 4040 SDRPGKRCAAEGSSPLLLLPDN 4061
Score = 42.7 bits (99), Expect = 0.002
Identities = 39/152 (25%), Positives = 57/152 (37%), Gaps = 41/152 (26%)
Query: 929 CTNTEGGYTCMCAGRLS---------EPGLICPDSTPPPHLREDDHHYSVRNSDSECPLS 979
C GGY+C C S + + P + PPP C
Sbjct: 4342 CLLRPGGYSCACPQGSSFIEGSTTECDAAIELPINLPPP-----------------CR-- 4382
Query: 980 HDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLKWWELRHAGHGQQQKVIVVAVC 1039
C+H G C Y + D C C GY G+ C+ K G + V +
Sbjct: 4383 ----CMHGGNC-YFDETDLPKCKCPSGYTGKYCEMAFSK-------GISPGTTAVAVLLT 4430
Query: 1040 VVVLVMLLLLSLWG-AHYYRTQKLLSKNPKNP 1070
++++V++ L++ G HY RT LL PK P
Sbjct: 4431 ILLIVVIGALAIAGFFHYRRTGSLLPALPKLP 4462
Score = 42.0 bits (97), Expect = 0.004
Identities = 26/72 (36%), Positives = 33/72 (45%), Gaps = 8/72 (11%)
Query: 835 CAPVGCSMYARCISEGEDATCQCLKGFAG---DGKLCSDIDECEMGVPVCPPASSKCINT 891
CA C ++EG C C GF D C DI+ECE CP C NT
Sbjct: 3970 CAENICEQNCTQLNEG-GFICSCTAGFETNVFDRTSCLDINECEQ-FGTCP---QHCRNT 4024
Query: 892 EGGYVCRCSEGY 903
+G Y C C++G+
Sbjct: 4025 KGSYECVCADGF 4036
Score = 39.3 bits (90), Expect = 0.023
Identities = 19/45 (42%), Positives = 24/45 (53%)
Query: 745 CLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLL 789
C NGGC H C + A C C GF+ A+D KTC +D +L
Sbjct: 1353 CSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDIL 1397
Score = 38.9 bits (89), Expect = 0.030
Identities = 21/72 (29%), Positives = 30/72 (41%), Gaps = 13/72 (18%)
Query: 750 GGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLDILSKT 809
G C C G+ CSC G+M SDG+TC LL L + S+
Sbjct: 1398 GSCSQHCYNMRGSFRCSCDTGYMLESDGRTCKVTASESLL-------------LLVASQN 1444
Query: 810 RVSEDNITESQH 821
++ D++T H
Sbjct: 1445 KIIADSVTSQVH 1456
Score = 36.2 bits (82), Expect = 0.19
Identities = 19/72 (26%), Positives = 32/72 (44%), Gaps = 9/72 (12%)
Query: 835 CAPVGCSMYARCISEGEDATCQCLKGFA---GDGKLCSDIDECEMGVPVCPPASSKCINT 891
C+ + C +C C C G+ D + C + D+C++ +C KC +
Sbjct: 312 CSALNCQY--QCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIW-GIC---DQKCESR 365
Query: 892 EGGYVCRCSEGY 903
G ++C C EGY
Sbjct: 366 PGRHLCHCEEGY 377
Score = 34.3 bits (77), Expect = 0.74
Identities = 58/247 (23%), Positives = 83/247 (33%), Gaps = 63/247 (25%)
Query: 792 GEVDLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQ-DDCAPV----GCSMYARC 846
G+VD + ++ SE+ T + + +I D+ +DC GC +Y C
Sbjct: 2974 GDVDCTDGYDENQNCTRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGC-LYQTC 3032
Query: 847 ISEGEDATCQ---CL-KGFAGD-GKLCSDIDE-----CEMGVPVCPPASSKCINTEGGYV 896
+ TCQ C+ K F D C D + C P CPP KC N
Sbjct: 3033 --QQNQFTCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNG----- 3085
Query: 897 CRCSEGYQGDGIHCLDIDEC--QLGEHSCGENA-----------SCTNTEGGYTCMCAGR 943
RC E + C +D+C E CG N +CT+T + C C
Sbjct: 3086 -RCIEMMK----LCNHLDDCLDNSDEKGCGINECHDPSISGCDHNCTDTLTSFYCSCR-- 3138
Query: 944 LSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCLHDGVCMYIEALDKYACNC 1003
P L D + +E P C + + Y C C
Sbjct: 3139 ------------PGYKLMSDKRTCVDIDECTEMPFVCSQKCEN--------VIGSYICKC 3178
Query: 1004 VVGYIGE 1010
GY+ E
Sbjct: 3179 APGYLRE 3185
Score = 31.2 bits (69), Expect = 6.2
Identities = 17/44 (38%), Positives = 20/44 (45%), Gaps = 2/44 (4%)
Query: 748 QNGGCEHICKKRLGTAWCSCREGFMKASD--GKTCLALDGHQLL 789
Q G C C+ G+ C C +GF SD GK C A LL
Sbjct: 4013 QFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLL 4056
>gi|4504975 low density lipoprotein receptor precursor [Homo
sapiens]
Length = 860
Score = 229 bits (583), Expect = 2e-59
Identities = 130/399 (32%), Positives = 208/399 (52%), Gaps = 22/399 (5%)
Query: 401 CPRNVSECSHDCVLTSEGPLCFCPEGS--VLERDGKTCSGCSSPDNGGCSQLCVPLSPVS 458
C N CSH C G C CP+G V +R + C PD CSQLCV L
Sbjct: 318 CLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDT--CSQLCVNLEG-G 374
Query: 459 WECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALD 518
++C C G+ L K+C A G +L F N ++R M D ++Y +L+ +V ALD
Sbjct: 375 YKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVV-ALD 433
Query: 519 HDPVENKIYFAHTALKWIERANMDG----SQRERLIEEGVDVPEGLAVDWIGRRFYWTDR 574
+ N+IY++ + + I +D S + +I + P+GLAVDWI YWTD
Sbjct: 434 TEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDS 493
Query: 575 GKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRL 634
+ +D G + K + +EN S+PR I V P+ ++WTD G +I+ L G+
Sbjct: 494 VLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIY 553
Query: 635 VIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQND--VGHPFAVAV 692
+ + ++ WP+GIT+D L+ +LYW D+K I +++G R+ + +++ + HPF++AV
Sbjct: 554 SLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAV 613
Query: 693 FEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAKP-GADPC---LYQ 748
FED V+++D ++ N+ TG D L ++L P +V+ H L +P G + C
Sbjct: 614 FEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLS 673
Query: 749 NGGCEHIC------KKRLGTAWCSCREGFMKASDGKTCL 781
NGGC+++C C+C +G + A D ++CL
Sbjct: 674 NGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCL 712
Score = 103 bits (257), Expect = 1e-21
Identities = 87/363 (23%), Positives = 163/363 (44%), Gaps = 32/363 (8%)
Query: 18 VSLSAPQHWSCPEGTLAGNGNSTC--VGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGV 75
V+L C EG C VG +L F++ + + ++ + + Y L+ +
Sbjct: 369 VNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRN 428
Query: 76 SVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVS-------GMAINWINE 128
V +D RIYW DL ++++ L+ R V + + +S G+A++WI+
Sbjct: 429 VVALDTEVASNRIYWSDLSQRMICSTQLD--RAHGVSSYDTVISRDIQAPDGLAVDWIHS 486
Query: 129 EVIWSNQQEGIITVTDMKGNNSHILLSAL-KYPANVAVDPVERFIFWSS-EVAGSLYRAD 186
+ W++ G ++V D KG L P + VDPV F++W+ + +
Sbjct: 487 NIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGG 546
Query: 187 LDGVGVKALL-ETSEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGS--VHISKH 243
L+GV + +L+ E + ++LD+L RL+W+ + I S D +GG+ +
Sbjct: 547 LNGVDIYSLVTENIQWPNGITLDLLSGRLYWV----DSKLHSISSIDVNGGNRKTILEDE 602
Query: 244 PTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQ 303
+ F++++F D++F++ + I+ AN+ TG D+ L + + ++ + H L Q
Sbjct: 603 KRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNL--LAENLLSPEDMVLFHNLTQ 660
Query: 304 PKAEDDTWEPEQKLCKLRKGNCS-STVCGQDLQSH----LCMCAEGYALSRDRKYCEDVN 358
P+ + W + L G C + + H C C +G L+RD + C
Sbjct: 661 PRGVN--W---CERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEA 715
Query: 359 ECA 361
E A
Sbjct: 716 EAA 718
Score = 72.0 bits (175), Expect = 3e-12
Identities = 86/350 (24%), Positives = 136/350 (38%), Gaps = 31/350 (8%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGS 377
C G CS VC + C+C +G+ L R+ CED++EC C+ C N G
Sbjct: 318 CLDNNGGCSH-VCNDLKIGYECLCPDGFQLVAQRR-CEDIDECQD-PDTCSQLCVNLEGG 374
Query: 378 YYCTCPVGFVLLPDGKRCHQLVSCP----RNVSECSHDCVLTSEGPLCFCPEGSVLERDG 433
Y C C GF L P K C + S N E + SE +V+ D
Sbjct: 375 YKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDT 434
Query: 434 KTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPG---YDLQLDEKSCAASGPQPFLLFANS 490
+ S + +C S + D G YD + A G + +N
Sbjct: 435 EVASNRIYWSDLSQRMIC------STQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNI 488
Query: 491 Q-------DIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAH--TALKWIERANM 541
+ G TL + A+ DPV +Y+ T K I++ +
Sbjct: 489 YWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAK-IKKGGL 547
Query: 542 DGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKE--NISQ 599
+G L+ E + P G+ +D + R YW D I D+NG K I ++ ++
Sbjct: 548 NGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAH 607
Query: 600 PRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITI 649
P +AV ++FWTD IN I S++ + + + +L+ P + +
Sbjct: 608 PFSLAV--FEDKVFWTDI-INEAIFSANRLTGSDVNLLAENLLSPEDMVL 654
Score = 47.0 bits (110), Expect = 1e-04
Identities = 28/69 (40%), Positives = 35/69 (50%), Gaps = 7/69 (10%)
Query: 839 GCSMYARCISEGEDATCQCLKGFAGDG-KLCSDIDECEMGVPVCPPASSKCINTEGGYVC 897
GCS + G + C C GF + C DIDEC+ C S C+N EGGY C
Sbjct: 324 GCSHVCNDLKIGYE--CLCPDGFQLVAQRRCEDIDECQ-DPDTC---SQLCVNLEGGYKC 377
Query: 898 RCSEGYQGD 906
+C EG+Q D
Sbjct: 378 QCEEGFQLD 386
Score = 46.2 bits (108), Expect = 2e-04
Identities = 43/141 (30%), Positives = 52/141 (36%), Gaps = 17/141 (12%)
Query: 812 SEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARC-------ISEGEDATCQCLKGFAGD 864
S+ N E D D VGC C GE T + A D
Sbjct: 244 SDGNCIHGSRQCDREYDCKDMSD--EVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARD 301
Query: 865 GKLCSDIDECEMGVPVCPP----ASSKCINTEGGYVCRCSEGYQGDGIH-CLDIDECQLG 919
+ SD E G C S C + + GY C C +G+Q C DIDECQ
Sbjct: 302 CRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQ-D 360
Query: 920 EHSCGENASCTNTEGGYTCMC 940
+C + C N EGGY C C
Sbjct: 361 PDTCSQ--LCVNLEGGYKCQC 379
Score = 35.8 bits (81), Expect = 0.25
Identities = 14/36 (38%), Positives = 19/36 (52%)
Query: 736 PLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREGF 771
P+ + G + CL NGGC H+C C C +GF
Sbjct: 309 PIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGF 344
>gi|93102379 low density lipoprotein-related protein 1B precursor
[Homo sapiens]
Length = 4599
Score = 227 bits (578), Expect = 6e-59
Identities = 138/406 (33%), Positives = 209/406 (51%), Gaps = 25/406 (6%)
Query: 391 DGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDNG-GCSQ 449
D + CH + VS CS DC C C G L+ DGKTC +G CSQ
Sbjct: 2921 DERNCHINECLSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQ 2980
Query: 450 LCVPLSPVSWECDCFPGYDLQLDEKS-CAA-SGPQPFLLFANSQDIRHMHFDGTDYGTLL 507
C+ +++C C GY++Q D + C + S +PFL+ A+ +IR + DG++Y TLL
Sbjct: 2981 QCINTYG-TYKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNY-TLL 3038
Query: 508 SQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVD--------VPEG 559
Q + V A+D D E IY WI+ + +GS+ R+ G D VP
Sbjct: 3039 KQGLNNVIAIDFDYREEFIY-------WIDSSRPNGSRINRMCLNGSDIKVVHNTAVPNA 3091
Query: 560 LAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGI 619
LAVDWIG+ YW+D K +I S LNG I+ + + PR +++ P A L+W D
Sbjct: 3092 LAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCE 3151
Query: 620 NPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRL 679
P I + G + V+ + + P +TID++ +LYW D ++ IE +N+DGS R ++
Sbjct: 3152 YPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWAD--ENHIEFSNMDGSHRHKV 3209
Query: 680 TQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAK 739
D+ A+ +FEDY++++D S+ R +K +G DR+ L S + + V H +
Sbjct: 3210 PNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQ 3269
Query: 740 PGADP--CLYQNGGCEHICKKRLG-TAWCSCREGFMKASDGKTCLA 782
P C+ NGGC H+C G T C+C F A+D +TCL+
Sbjct: 3270 PDVSKHLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTCLS 3315
Score = 214 bits (546), Expect = 3e-55
Identities = 128/371 (34%), Positives = 197/371 (53%), Gaps = 10/371 (2%)
Query: 428 VLERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLF 487
V +++ + S +NGGCSQLC+P S + C C GY LQ + SC G + FL++
Sbjct: 1826 VYDKEAQQGSNSCQLNNGGCSQLCLPTSETTRTCMCTVGYYLQKNRMSC--QGIESFLMY 1883
Query: 488 ANSQDIRHMHFDGTDYGTLLSQQMGMVYA--LDHDPVENKIYFAHTALKWIERANMDGSQ 545
+ + IR + + +D L G +A +D + IY+ I RA D +
Sbjct: 1884 SVHEGIRGIPLEPSDKMDALMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTW 1943
Query: 546 RERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAV 605
+E +I G+ EG+AVDWI YWTD G +LI + LNG +I + + QPR IAV
Sbjct: 1944 KEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAV 2003
Query: 606 HPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSV 665
HP LFWT+ G P I + L G ++V+ S + WP+GI+ID+ +KLYWCDA+
Sbjct: 2004 HPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDK 2063
Query: 666 IEMANLD-GSKRRRLTQNDVGHPFAVAVFEDYVWFSD--WAMPSVMRVNKRTGKDRVRLQ 722
IE +L+ G R + F+VAVF Y+++SD A SV R +K + + ++
Sbjct: 2064 IERIDLETGGNREMVLSGSNVDMFSVAVFGAYIYWSDRAHANGSVRRGHKNDATETITMR 2123
Query: 723 -GSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHICKKRLGT-AWCSCREGFMKASDGKTC 780
G + + + + + + G + C NGGC+ +C R + C+C G++ A DG TC
Sbjct: 2124 TGLGVNLKEVKIFNRVREKGTNVCARDNGGCKQLCLYRGNSRRTCACAHGYL-AEDGVTC 2182
Query: 781 LALDGHQLLAG 791
L +G+ L +G
Sbjct: 2183 LRHEGYLLYSG 2193
Score = 197 bits (500), Expect = 7e-50
Identities = 135/425 (31%), Positives = 204/425 (48%), Gaps = 24/425 (5%)
Query: 382 CPVGFVLLPDGKRCHQLVSCPRNVSECSHDC-VLTSEGPLCFCPEGSVLERDGKTCSGCS 440
CP G +G C + C N CS+ C V+ G +C CPEG L +D KTC
Sbjct: 1163 CPDGS---DEGYLCDE---CSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVD 1216
Query: 441 SPDNG-GCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGP-QPFLLFANSQDIRHMHF 498
N CSQ+C +C C+ G+ L +D +SC + P + F++F+ +IR +
Sbjct: 1217 YCSNHLKCSQVCEQHKHTV-KCSCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDL 1275
Query: 499 DGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQR----ERLIEEGV 554
DY +LL + ALD ++ +Y+ I R + S E ++E G+
Sbjct: 1276 HKRDY-SLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGL 1334
Query: 555 DVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFW 614
PEGL VDWI YW D I + L+G + + PR IA+ P LFW
Sbjct: 1335 ATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFW 1394
Query: 615 TDTGIN-PRIESSSLQGLGRLVIAS--SDLIWPSGITIDFLTDKLYWCDAKQSVIEMANL 671
TD N PRIES+S+ G GR I WP+G+T+D ++ W DA+ I A
Sbjct: 1395 TDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALY 1454
Query: 672 DGSKRRRLTQND--VGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPS 729
DG+ + + + HPFAV+++ V+++DW ++ + NK TG++ +Q + +P
Sbjct: 1455 DGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPF 1514
Query: 730 SLVVVHPLAKPGA-DPCLYQN--GGCEHICK-KRLGTAWCSCREGFMKASDGKTCLALDG 785
L + HP +P A +PC + G C H+C +A C+C +SD KTC +
Sbjct: 1515 DLQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHNRSAACACPHLMKLSSDKKTCYEMKK 1574
Query: 786 HQLLA 790
L A
Sbjct: 1575 FLLYA 1579
Score = 181 bits (458), Expect = 5e-45
Identities = 148/538 (27%), Positives = 240/538 (44%), Gaps = 68/538 (12%)
Query: 445 GGCSQLCVPLSPVSWE-CDCFPGYDLQLDEKSCAASGPQPFLLFANSQD--IRHMHFDG- 500
GGCS +C+ S C C G++L D +SC + FL + + +R M +
Sbjct: 484 GGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRPKNELFLFYGKGRPGIVRGMDLNTK 543
Query: 501 -TDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEG 559
D + + + ALD N IYFA T I R +DG++RE ++++ +D EG
Sbjct: 544 IADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEG 603
Query: 560 LAVDWIGRRFYWTDRG--KSL-IGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTD 616
+AVDWIG YWT+ G K++ + R + + K + + +S PRGI V P+ ++WTD
Sbjct: 604 IAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTD 663
Query: 617 TGINP------RIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMAN 670
+ RIE + + G R + +S ++WP+G+T+DF T+ LYWCDA IE
Sbjct: 664 WEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVF 723
Query: 671 LDGSKRRRL-TQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPS 729
L+G+ R+ + + ++ HPF ++ +YV+++D+ S+ +++ T + + L+
Sbjct: 724 LNGTHRKIVYSGRELNHPFGLSHHGNYVFWTDYMNGSIFQLDLITSEVTL-LRHERPPLF 782
Query: 730 SLVVVHPLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQL- 788
L + P + G + C NGGC +C G C+C + + +G TC G L
Sbjct: 783 GLQIYDPRKQQGDNMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFNPGEALP 842
Query: 789 --LAGGEVDLKNQVT---------PLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAP 837
GE KN+ D L + ED++ H + + C P
Sbjct: 843 HICKAGEFRCKNRHCIQARWKCDGDDDCLDGS--DEDSVNCFNHSCPDDQFKCQNNRCIP 900
Query: 838 VG--CSMYARCISEGEDA-------TCQCLKGFAGDGK------LCSDIDEC-----EMG 877
C C S +++ TCQ + G+G+ LC D+C EM
Sbjct: 901 KRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMA 960
Query: 878 ---VPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCLDIDECQLGE------HSCGEN 926
P C P + +VC+ HC D+C G HSC +N
Sbjct: 961 SCEFPTCEPLTQ--------FVCKSGRCISSKW-HCDSDDDCGDGSDEVGCVHSCFDN 1009
Score = 160 bits (405), Expect = 7e-39
Identities = 125/482 (25%), Positives = 200/482 (41%), Gaps = 54/482 (11%)
Query: 330 CGQDLQSHLCMCAEGYALSRDRKY--CEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFV 387
C D L C E + + C N+C + C + CP G+
Sbjct: 58 CPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCVHLSQLC---------NGVLDCPDGY- 107
Query: 388 LLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSS-PDNGG 446
+G C +L+S + ++ C + C + C+C +G + DG++C G
Sbjct: 108 --DEGVHCQELLSNCQQLN-CQYKCTMVRNSTRCYCEDGFEITEDGRSCKDQDECAVYGT 164
Query: 447 CSQLCVPLSPVSWECDCFPGYDLQLDEKSCAA----SGPQPFLLFANSQDIRHMHFDGTD 502
CSQ C S+ C C GY +Q D +SC A + P LL AN + I + +G+
Sbjct: 165 CSQTCRNTHG-SYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLNGSK 223
Query: 503 YGTLLSQQMGMVYALDHDPVENKIYFAHTA-----LKWIERANMDGSQRERLIE--EGVD 555
TL S ++ LD E+ I + + LK I+ G E I +
Sbjct: 224 MATLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQSFH 283
Query: 556 VPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWT 615
+ +A+DW+ R Y+ D I + NG + + P+ IAV P+A +LF+T
Sbjct: 284 NVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFFT 343
Query: 616 DTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSK 675
D G ++E + G+ R I S P+ + +D + +YW D + + + G
Sbjct: 344 DYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQGKN 403
Query: 676 RRRLTQ-NDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKD-----------RVRLQG 723
R + Q V H + + VFEDY++ ++ +++R+N+ G D +R+
Sbjct: 404 RHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIKIENAWGIRIYQ 463
Query: 724 SMLKP---SSLVVVHPLAKPGADPCLYQNGGCEHIC--KKRLGTAWCSCREGFMKASDGK 778
+P S V P P GGC HIC T C CR GF SDG+
Sbjct: 464 KRTQPTVRSHACEVDPYGMP---------GGCSHICLLSSSYKTRTCRCRTGFNLGSDGR 514
Query: 779 TC 780
+C
Sbjct: 515 SC 516
Score = 140 bits (354), Expect = 6e-33
Identities = 176/727 (24%), Positives = 268/727 (36%), Gaps = 109/727 (14%)
Query: 400 SCPRNVSECSHD--CVLTSEGPLCFCPEGSVLERDGKTCSGCSSP-DNGGCSQLCVPLSP 456
+C NV+ C D C C C G + C + G CS C+ +
Sbjct: 3804 TCEDNVNPCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFGTCSHQCINVEG 3863
Query: 457 VSWECDCFPGYDLQLDEKSCAASGPQPFLLF-ANSQDIRHMHFDGTDYGTLLSQQMGMVY 515
S++C C + Q +C A G + +L+ AN DI G Y S +
Sbjct: 3864 -SYKCVCDQNF--QERNNTCIAEGSEDQVLYIANDTDIL-----GFIYPFNYSGDHQQIS 3915
Query: 516 ALDHDP--VENKIYFAHTALKWIERANMDG-------SQRERLIEEGVDVPE-----GLA 561
++H+ +Y+ + W + N G + +R G+ PE +A
Sbjct: 3916 HIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFKRPRDIA 3975
Query: 562 VDWIGRRFYWTDRGKS---------------LIGRSDLNGKRSKIITKENISQPRGIAVH 606
VDW+ YWTD + I LNG + +P IAV+
Sbjct: 3976 VDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVN 4035
Query: 607 PMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVI 666
P ++WT G + IE +++ G R ++ +L P+G+ +D+ ++++YW D + S+I
Sbjct: 4036 PKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFELSII 4095
Query: 667 EMANLDGSKRRRLTQNDVG--HPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGS 724
DGS + G HP + +FEDY+ + V RV K L +
Sbjct: 4096 GSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYI-YGAGPKNGVFRVQKFGHGSVEYLALN 4154
Query: 725 MLKPSSLVVVHPLAKPG-ADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLAL 783
+ K +++ H + +PCL + CE +C A C C EG K TC
Sbjct: 4155 IDKTKGVLISHRYKQLDLPNPCL--DLACEFLCLLNPSGATCVCPEG--KYLINGTC--- 4207
Query: 784 DGHQLLAGGEVDLKNQVTPLDILSKTRVSEDN--ITESQHMLVAEIMVS-DQDDCAPVGC 840
N + LD K I + L S + C C
Sbjct: 4208 --------------NDDSLLDDSCKLTCENGGRCILNEKGDLRCHCWPSYSGERCEVNHC 4253
Query: 841 SMYAR----CI-SEGEDATCQCLKGFAGD--GK-LCSDIDECEMGVPVCPPASSKCINTE 892
S Y + C+ S TC C GF G GK +C D C+ G CI T
Sbjct: 4254 SNYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKTVCEDF--CQNG--------GTCIVTA 4303
Query: 893 GGY-VCRCSEGYQGDGIHCLDIDECQ--LGEHSCGENASCT-NTEGGYTCMCAGRLSEPG 948
G C C Y G D CQ + H C + SCT +G C+C R P
Sbjct: 4304 GNQPYCHCQPEYTG--------DRCQYYVCHHYCVNSESCTIGDDGSVECVCPTRYEGPK 4355
Query: 949 ------LICPDSTPPPHLREDDHHYSVRNSD--SECPLSHDGYCLHDGVCMYIEALDKYA 1000
+ C + +D + N S C L DGYC + G C +
Sbjct: 4356 CEVDKCVRCHGGHCIINKDSEDIFCNCTNGKIASSCQLC-DGYCYNGGTCQLDPETNVPV 4414
Query: 1001 CNCVVGYIGERCQYRDLKWWELRHAGHGQQQKVIVVAVCVVVLVMLLLLSLWGAHYYRTQ 1060
C C + G +C+ K + H + +IV V +V L+ L++ L R
Sbjct: 4415 CLCSTNWSGTQCERPAPKSSKSDHIS-TRSIAIIVPLVLLVTLITTLVIGLVLCKRKRRT 4473
Query: 1061 KLLSKNP 1067
K + + P
Sbjct: 4474 KTIRRQP 4480
Score = 134 bits (338), Expect = 4e-31
Identities = 93/326 (28%), Positives = 164/326 (50%), Gaps = 24/326 (7%)
Query: 36 NGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHYNEKRIYWVDLER 95
NG + PFLI + + I +I T+G+NY L + +DF Y E+ IYW+D R
Sbjct: 3005 NGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDFDYREEFIYWIDSSR 3064
Query: 96 ---QLLQRVFLNGSRQERVCNIEKNVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHI 152
+ R+ LNGS + V N + +A++WI + + WS+ ++ II V+ + G I
Sbjct: 3065 PNGSRINRMCLNGSDIKVVHNTAV-PNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTI 3123
Query: 153 LLS-ALKYPANVAVDPVERFIFWSSEVA-GSLYRADLDGVGVKALLETS-EKITAVSLDV 209
L+S LK+P ++++DP +++W + R +DG ++ET + A+++D
Sbjct: 3124 LVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDY 3183
Query: 210 LDKRLFWIQYNR-EGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFYSTWKMKT 268
+++RL+W N E SN DG H + + A++LF D I+++ K K+
Sbjct: 3184 VNRRLYWADENHIEFSN-------MDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKS 3236
Query: 269 IWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSST 328
+ A+K +G D R++L S+ + +++V H QP + + LC + G CS
Sbjct: 3237 LSRAHKTSGAD--RLSLIYSWHAITDIQVYHSYRQP-------DVSKHLCMINNGGCSHL 3287
Query: 329 VCGQDLQSHLCMCAEGYALSRDRKYC 354
++H C C + L+ D + C
Sbjct: 3288 CLLAPGKTHTCACPTNFYLAADNRTC 3313
Score = 132 bits (333), Expect = 2e-30
Identities = 142/577 (24%), Positives = 231/577 (40%), Gaps = 79/577 (13%)
Query: 443 DNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHF-DGT 501
DNGGC QLC+ C C GY L E + +LL++ ++ +H D T
Sbjct: 2150 DNGGCKQLCLYRGNSRRTCACAHGY---LAEDGVTCLRHEGYLLYSGRTILKSIHLSDET 2206
Query: 502 DYGTLLSQQMGMVY-------ALDHDPVE---NKIYFAHTALKWIERANMDGSQRERLIE 551
+ + + Y A D++ N+I+++ I+ D + ++I
Sbjct: 2207 NLNSPIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYSDAHFGNIQLIK-DNWEDRQVIV 2265
Query: 552 EGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKR------SKIITKENISQPRGIAV 605
E V EGLA YWT S I R ++ R +IT P +A+
Sbjct: 2266 ENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLAL 2325
Query: 606 HPMAKRLFWTDTGI-NPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQS 664
+FWT+ +P I S+L G V+ S+D++ P+G+TID+ +KLY+ D
Sbjct: 2326 DECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLG 2385
Query: 665 VIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGS 724
IE DGS+R + ++ G ++AV+++Y+++SDW +++R NK TG D L+
Sbjct: 2386 KIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRSD 2445
Query: 725 M-LKPSSLV-VVHPLAKPGADPCLYQNGGCEHIC-KKRLGTAWCSCREGFMKASDGK--- 778
+ +P ++ V + PC NGGC +C G CSCR + D +
Sbjct: 2446 IPHQPMGIIAVANDTNSCELSPCALLNGGCHDLCLLTPNGRVNCSCRGDRILLEDNRCVT 2505
Query: 779 ---TCLALDGHQLLAGGEVDLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDC 835
+C A + G +D +++ D I + +++ + C
Sbjct: 2506 KNSSCNAYSEFECGNGECIDY-------------QLTCDGIPHCKDKSDEKLLYCENRSC 2552
Query: 836 APVGCSMY-ARCISEGEDATCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGG 894
Y RCI G+ C G+ + DE + V C +C +G
Sbjct: 2553 RRGFKPCYNRRCIPHGK--LCD------GENDCGDNSDELDCKVSTCATVEFRC--ADGT 2602
Query: 895 YVCRCSEGYQGDGIHCLDIDECQLGEHSCGENASCTN-------TEGGYTCMCAGRLSEP 947
+ R + Q I C D + E +C N CT+ T G C P
Sbjct: 2603 CIPRSARCNQ--NIDCADASD----EKNC-NNTDCTHFYKLGVKTTGFIRCNSTSLCVLP 2655
Query: 948 GLICPDSTPPPHLREDDHHYSVRNSDSECPLSHDGYC 984
IC S D YS + +CP+ + C
Sbjct: 2656 TWICDGS-------NDCGDYS---DELKCPVQNKHKC 2682
Score = 131 bits (329), Expect = 4e-30
Identities = 91/357 (25%), Positives = 164/357 (45%), Gaps = 20/357 (5%)
Query: 439 CSSPDNGG-CSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMH 497
C++ D G CS +C+ S C C L D+K+C + FLL+A +IR +
Sbjct: 1531 CAANDGKGPCSHMCLINHNRSAACACPHLMKLSSDKKTCYEM--KKFLLYARRSEIRGVD 1588
Query: 498 FDGTDYGTLLS---QQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGV 554
D + + + + V +D D E ++Y+ + I+RA ++G+ E +I +
Sbjct: 1589 IDNPYFNFITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFINGTGLETVISRDI 1648
Query: 555 DVPEGLAVDWIGRRFYWT----DRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAK 610
GLAVDW+ R YW D + + R D + K S I I +P+ +A HP+
Sbjct: 1649 QSIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSII---HGIDKPQCLAAHPVRG 1705
Query: 611 RLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMAN 670
+L+WTD I +++ G ++ + P G++ID++ +KLYW + I N
Sbjct: 1706 KLYWTD---GNTINMANMDGSNSKILFQNQK-EPVGLSIDYVENKLYWISSGNGTINRCN 1761
Query: 671 LDGSKRRRL--TQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKP 728
LDG + + ++ A+ + + +W++D + + +KR G++ L+
Sbjct: 1762 LDGGNLEVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPTILRNKTSGV 1821
Query: 729 SSLVVVHPLAKPGADPCLYQNGGCEHICKKRLGTA-WCSCREGFMKASDGKTCLALD 784
+ V A+ G++ C NGGC +C T C C G+ + +C ++
Sbjct: 1822 VHMKVYDKEAQQGSNSCQLNNGGCSQLCLPTSETTRTCMCTVGYYLQKNRMSCQGIE 1878
Score = 123 bits (308), Expect = 1e-27
Identities = 76/340 (22%), Positives = 158/340 (46%), Gaps = 26/340 (7%)
Query: 27 SCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYEQL----VVDAGVSVIMDFH 82
+CP + TC FL+++ + I +D + + + V D ++DF
Sbjct: 1555 ACPHLMKLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFD 1614
Query: 83 YNEKRIYWVDLERQLLQRVFLNGSRQERVCNIE-KNVSGMAINWINEEVIW--SNQQEGI 139
+E+R+YW D++ Q ++R F+NG+ E V + + +++ G+A++W++ + W S E
Sbjct: 1615 ASEERLYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQ 1674
Query: 140 ITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALLETS 199
I V + G+ ++ + P +A PV ++W+ ++ A++DG K L +
Sbjct: 1675 INVARLDGSLKTSIIHGIDKPQCLAAHPVRGKLYWTD--GNTINMANMDGSNSKILFQNQ 1732
Query: 200 EKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQH--NLFAMSLFGD 257
++ +S+D ++ +L+WI N I C+ DGG++ + + + A+++
Sbjct: 1733 KEPVGLSIDYVENKLYWI----SSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDK 1788
Query: 258 RIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKL 317
+++++ + + +K G++ + +S VVH K D +
Sbjct: 1789 KLWWADQNLAQLGTCSKRDGRNPTILRNKTS-------GVVH----MKVYDKEAQQGSNS 1837
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDV 357
C+L G CS + CMC GY L ++R C+ +
Sbjct: 1838 CQLNNGGCSQLCLPTSETTRTCMCTVGYYLQKNRMSCQGI 1877
Score = 121 bits (303), Expect = 5e-27
Identities = 96/351 (27%), Positives = 161/351 (45%), Gaps = 32/351 (9%)
Query: 27 SCPEGTLAGNGNSTCVGPAPF---LIFSHGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHY 83
SC EG +C PF +IFS + I RID +Y LV ++ +DFH+
Sbjct: 1238 SCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALDFHF 1297
Query: 84 NEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNV-------SGMAINWINEEVIWSNQQ 136
N+ +YW D+ + R L S V IE V G+ ++WI + W +
Sbjct: 1298 NQSLLYWTDVVEDRIYRGKL--SESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSN 1355
Query: 137 EGIITVTDMKGN-NSHILLSALKYPANVAVDPVERFIFWSSEVAG--SLYRADLDGVGVK 193
I V + G+ + ++ A+++P +A+DP +FW+ A + A + G G K
Sbjct: 1356 LDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRK 1415
Query: 194 AL---LETSEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSV--HISKHPTQHN 248
+ ++T +++D +KR+ W + + I S YDG ++ I H +
Sbjct: 1416 TIYKDMKTGAWPNGLTVDHFEKRIVW----TDARSDAIYSALYDGTNMIEIIRGHEYLSH 1471
Query: 249 LFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAED 308
FA+SL+G ++++ W+ T+ ANK TG++ V + +S P +L++ HP QP+A
Sbjct: 1472 PFAVSLYGSEVYWTDWRTNTLSKANKWTGQN-VSVIQKTSAQPF-DLQIYHPSRQPQA-- 1527
Query: 309 DTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNE 359
P KG CS +S C C LS D+K C ++ +
Sbjct: 1528 ----PNPCAANDGKGPCSHMCLINHNRSAACACPHLMKLSSDKKTCYEMKK 1574
Score = 79.7 bits (195), Expect = 2e-14
Identities = 76/343 (22%), Positives = 143/343 (41%), Gaps = 37/343 (10%)
Query: 28 CPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTN-YEQLVVDAGVS--VIMDFHYN 84
C G +C G FL++S I I E ++ + L+ +G S V +DFH
Sbjct: 1861 CTVGYYLQKNRMSCQGIESFLMYSVHEGIRGIPLEPSDKMDALMPISGTSFAVGIDFHAE 1920
Query: 85 EKRIYWVDLERQLLQRVFLNGS-RQERVCNIEKNVSGMAINWINEEVIWSNQQEGIITVT 143
IYW D+ + R + + +++ + N V G+A++WI + W++ +I V
Sbjct: 1921 NDTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVA 1980
Query: 144 DMKGNNSHILLS-ALKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALLETSEKI 202
+ G+ ++++S L P ++AV P + +FW+ + +G KA L+ SEK+
Sbjct: 1981 RLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTE-------WGQMPCIG-KARLDGSEKV 2032
Query: 203 ----------TAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAM 252
+S+D + +L+W + + GG+ + + ++F++
Sbjct: 2033 VLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLE---TGGNREMVLSGSNVDMFSV 2089
Query: 253 SLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSF-VPLGELKVVHPLAQPKAEDDTW 311
++FG I++S + H I + + V L E+K+ + +
Sbjct: 2090 AVFGAYIYWSDRAHANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRVR--------- 2140
Query: 312 EPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYC 354
E +C G C + C CA GY L+ D C
Sbjct: 2141 EKGTNVCARDNGGCKQLCLYRGNSRRTCACAHGY-LAEDGVTC 2182
Score = 72.4 bits (176), Expect = 2e-12
Identities = 102/458 (22%), Positives = 177/458 (38%), Gaps = 67/458 (14%)
Query: 27 SCPEGTLAGNGNSTCVGPAPFLIFSHGN---SIFRIDTEGTN-----YEQLVVDAGVSVI 78
+C G LA +G TC+ +L++S SI D N YE V +
Sbjct: 2169 ACAHGYLAEDG-VTCLRHEGYLLYSGRTILKSIHLSDETNLNSPIRPYENPRYFKNV-IA 2226
Query: 79 MDFHYNEKR-----IYWVDLERQLLQRVFLNGSRQERVCNIEKNVSGMAINWINEEVIWS 133
+ F YN++R I++ D +Q + N ++ + +V G+A + + + W+
Sbjct: 2227 LAFDYNQRRKGTNRIFYSDAHFGNIQLIKDNWEDRQVIVENVGSVEGLAYHRAWDTLYWT 2286
Query: 134 NQQEGIITVTDMK-------GNNSHILLSALKYPANVAVDPVERFIFWSS--EVAGSLYR 184
+ IT + + I +S +P +A+D + +FW++ E S+ R
Sbjct: 2287 SSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQHPSIMR 2346
Query: 185 ADLDGVGVKALLETSEKI-TAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKH 243
+ L G + ++ T +++D ++L++ +GS I C+YDG H+
Sbjct: 2347 STLTGKNAQVVVSTDILTPNGLTIDYRAEKLYF----SDGSLGKIERCEYDGSQRHVIVK 2402
Query: 244 PTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQ 303
+++++ + IF+S W + I +NK+TG D + P+G + V
Sbjct: 2403 SGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRSDIPHQPMGIIAVA----- 2457
Query: 304 PKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRK------YCEDV 357
+DT E C L G C C C L D + C
Sbjct: 2458 ----NDTNSCELSPCALLNGGCHDLCLLTPNGRVNCSCRGDRILLEDNRCVTKNSSCNAY 2513
Query: 358 NECAFWNHGC---TLGCKNTPGS--------YYC---TCPVGFV------LLPDGKRCHQ 397
+E N C L C P YC +C GF +P GK C
Sbjct: 2514 SEFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDG 2573
Query: 398 LVSCPRNVSECSHDCVLTSEGPLCF-CPEGSVLERDGK 434
C N E DC +++ + F C +G+ + R +
Sbjct: 2574 ENDCGDNSDEL--DCKVSTCATVEFRCADGTCIPRSAR 2609
Score = 69.7 bits (169), Expect = 2e-11
Identities = 83/371 (22%), Positives = 156/371 (42%), Gaps = 37/371 (9%)
Query: 27 SCPEGTLAGNGNSTC---VGPA---PFLIFSHGNSIFRIDTEGTNYEQLVVDAGVSV-IM 79
SC EG L N +C + P P L+ ++ +I G+ L G + +
Sbjct: 179 SCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLNGSKMATLSSVNGNEIHTL 238
Query: 80 DFHYNEKRIYWVDL-----ERQLLQRVFLNGSRQERVCNIEK---NVSGMAINWINEEVI 131
DF YNE I W++ + + +Q G E NI + NV MAI+W+ +
Sbjct: 239 DFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQSFHNVQQMAIDWLTRNLY 298
Query: 132 WSNQQEGIITVTDMKGNNSHILLS-ALKYPANVAVDPVERFIFWSS-EVAGSLYRADLDG 189
+ + I V + G+ L+ L P +AVDP+ +F++ + R D+DG
Sbjct: 299 FVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMDG 358
Query: 190 VGVKALLET-SEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQ-H 247
+ ++++ +E+ A++LD+++K ++W+ + + DY G + H Q
Sbjct: 359 MNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLD----YVGVVDYQGKNRHTVIQGRQVR 414
Query: 248 NLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDM-VRINLHSSFVPLGELKVVHPLAQPKA 306
+L+ +++F D ++ + I N+ G D+ I + +++ +++ QP
Sbjct: 415 HLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIKIENAW----GIRIYQKRTQPTV 470
Query: 307 EDDTWEPEQKLCKLRKGNCSS-TVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNH 365
E + G CS + ++ C C G+ L D + C+ F +
Sbjct: 471 RSHACEVDP---YGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRPKNELFLFY 527
Query: 366 GCTLGCKNTPG 376
G K PG
Sbjct: 528 G-----KGRPG 533
Score = 69.7 bits (169), Expect = 2e-11
Identities = 70/317 (22%), Positives = 129/317 (40%), Gaps = 45/317 (14%)
Query: 79 MDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIE-KNVSGMAINWINEEVIWSNQQE 137
+DFH IY+ D L+ R ++G+ +E + + NV G+A++WI + W+N
Sbjct: 561 LDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGH 620
Query: 138 ----GIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWS-------SEVAGSLYRAD 186
+ + + +L + +P + VDPV +++W+ + G + +A
Sbjct: 621 RKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAW 680
Query: 187 LDGVGVKALLETSEKI--TAVSLDVLDKRLFWI-----QYNREGSNSLICSCDYDGGSVH 239
+DG + + TS+ + ++LD L+W + N Y G ++
Sbjct: 681 MDGFN-RQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELN 739
Query: 240 ISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVH 299
HP F +S G+ +F++ + +I+ + T + + L PL L++
Sbjct: 740 ---HP-----FGLSHHGNYVFWTDYMNGSIFQLDLITSEVTL---LRHERPPLFGLQIYD 788
Query: 300 PLAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNE 359
P Q +C++ G C ST+C +C CA+ L + C N
Sbjct: 789 PRKQ---------QGDNMCRVNNGGC-STLCLAIPGGRVCACADNQLLDENGTTC-TFNP 837
Query: 360 CAFWNHGCTLG---CKN 373
H C G CKN
Sbjct: 838 GEALPHICKAGEFRCKN 854
Score = 55.5 bits (132), Expect = 3e-07
Identities = 26/52 (50%), Positives = 31/52 (59%), Gaps = 6/52 (11%)
Query: 855 CQCLKGFA--GDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQ 904
C+C GF DGK C DIDEC G P S +CINT G Y C C++GY+
Sbjct: 2951 CKCWPGFQLKDDGKTCVDIDECSSGFP----CSQQCINTYGTYKCLCTDGYE 2998
Score = 49.3 bits (116), Expect = 2e-05
Identities = 27/79 (34%), Positives = 40/79 (50%), Gaps = 3/79 (3%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNH-GCTLGCKNTPG 376
C L G CS+ + +C C EG L++D K CE V+ C+ NH C+ C+
Sbjct: 1176 CSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCS--NHLKCSQVCEQHKH 1233
Query: 377 SYYCTCPVGFVLLPDGKRC 395
+ C+C G+ L DG+ C
Sbjct: 1234 TVKCSCYEGWKLDVDGESC 1252
Score = 48.5 bits (114), Expect = 4e-05
Identities = 43/129 (33%), Positives = 53/129 (41%), Gaps = 14/129 (10%)
Query: 845 RCISEGEDATCQCLKGFAGDGKLCSDIDEC-EMGVPVCPPASSKCINTEGGYVCRCSEGY 903
RCI G + G D + C I+EC V C S C + Y C+C G+
Sbjct: 2902 RCIPSGGLCDNKDDCGDGSDERNCH-INECLSKKVSGC---SQDCQDLPVSYKCKCWPGF 2957
Query: 904 Q--GDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMCAG----RLSEPGLICPDSTPP 957
Q DG C+DIDEC G C + C NT G Y C+C + P S
Sbjct: 2958 QLKDDGKTCVDIDECSSG-FPCSQ--QCINTYGTYKCLCTDGYEIQPDNPNGCKSLSDEE 3014
Query: 958 PHLREDDHH 966
P L DHH
Sbjct: 3015 PFLILADHH 3023
Score = 47.8 bits (112), Expect = 6e-05
Identities = 29/81 (35%), Positives = 33/81 (40%), Gaps = 10/81 (12%)
Query: 834 DCAPVGCSMYARCISEGEDATCQCLKGF--AGDGKLCSDIDECEMGVPVCPPASSKCINT 891
+C + C +C C C GF DG+ C D DEC V S C NT
Sbjct: 119 NCQQLNCQY--KCTMVRNSTRCYCEDGFEITEDGRSCKDQDECA----VYGTCSQTCRNT 172
Query: 892 EGGYVCRCSEGY--QGDGIHC 910
G Y C C EGY Q D C
Sbjct: 173 HGSYTCSCVEGYLMQPDNRSC 193
Score = 47.4 bits (111), Expect = 8e-05
Identities = 24/75 (32%), Positives = 32/75 (42%), Gaps = 2/75 (2%)
Query: 313 PEQKLCKLRKGNCSSTV-CGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGC 371
P + C+ C C Q S C C G+ + + CED+NEC + C+ C
Sbjct: 3800 PTEYTCEDNVNPCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFG-TCSHQC 3858
Query: 372 KNTPGSYYCTCPVGF 386
N GSY C C F
Sbjct: 3859 INVEGSYKCVCDQNF 3873
Score = 43.5 bits (101), Expect = 0.001
Identities = 106/470 (22%), Positives = 166/470 (35%), Gaps = 97/470 (20%)
Query: 88 IYWVDL-ERQLLQRVFLNGSRQERVCNIEKNVS---GMAINWINEEVIWSNQQEGIITVT 143
+YW+D E + RV ++G+ Q V IE +S + I+++N + W+++ I +
Sbjct: 3144 LYWIDCCEYPHIGRVGMDGTNQSVV--IETKISRPMALTIDYVNRRLYWADENH--IEFS 3199
Query: 144 DMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAGSLYRAD-LDGVGVKALLETSEKI 202
+M G++ H + + P +A+ E +I+W+ SL RA G +L+ + I
Sbjct: 3200 NMDGSHRHKVPNQ-DIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAI 3258
Query: 203 TAVSL-------DVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFA---- 251
T + + DV K L I N G + L C G H PT L A
Sbjct: 3259 TDIQVYHSYRQPDV-SKHLCMI--NNGGCSHL---CLLAPGKTHTCACPTNFYLAADNRT 3312
Query: 252 ------MSLFG---DRIFYSTWKMKTIWIANKHTGK--DMVRINLHSSFVPLGELKVVHP 300
S F D+ WK T+ + + D G P
Sbjct: 3313 CLSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALP 3372
Query: 301 LAQPKAEDDTWEPEQKL------CKLRKGNCSSTV--------------CGQDLQSHLC- 339
E+D + +L C + C+ CG + C
Sbjct: 3373 AFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCP 3432
Query: 340 --MCAEGYALSRDRKYC-------EDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLP 390
C+ Y + K+C ++ +CA + K T G + C + P
Sbjct: 3433 ENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCD-KKTCGPHEFQCKNNNCI-P 3490
Query: 391 DGKRCHQLVSCPRNVSE--------------CSH-DCVLTS---EGPLCFCPEGSVLERD 432
D RC C N E C++ DCV + +G C +GS D
Sbjct: 3491 DHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFD-CADGS----D 3545
Query: 433 GKTCSGCSSPDNGGCSQ-LCVPLSPVSWECDCFPGYDLQLDEKSCAASGP 481
+ C S D CS C+P W+CD DEKSC + P
Sbjct: 3546 ERNCETSCSKDQFRCSNGQCIP---AKWKCDGHEDCKYGEDEKSCEPASP 3592
Score = 43.5 bits (101), Expect = 0.001
Identities = 28/97 (28%), Positives = 42/97 (43%), Gaps = 8/97 (8%)
Query: 817 TESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQCLKGFAGDGK--LCSDIDEC 874
++ Q +A + +D+ P G Y I C+C GF + K C D++EC
Sbjct: 3791 SDEQGCRIAPTEYTCEDNVNPCGDDAYCNQIKTS--VFCRCKPGFQRNMKNRQCEDLNEC 3848
Query: 875 EMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCL 911
V S +CIN EG Y C C + +Q C+
Sbjct: 3849 L----VFGTCSHQCINVEGSYKCVCDQNFQERNNTCI 3881
Score = 43.5 bits (101), Expect = 0.001
Identities = 85/392 (21%), Positives = 153/392 (39%), Gaps = 57/392 (14%)
Query: 109 ERVCNIEKN--VSGMAINWINEEVIWSNQ-QEGIITVTDMKGN-----NSHILLSALKYP 160
+++ +IE N ++GM + + + +IWS Q G I + G NS ++ K P
Sbjct: 3912 QQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFKRP 3971
Query: 161 ANVAVDPVERFIFWS---------------SEVAGSLYRADLDGVGVKALL-ETSEKITA 204
++AVD V I+W+ + + S+ L+G LL + + A
Sbjct: 3972 RDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYA 4031
Query: 205 VSLDVLDKRLFWIQYNREGSNSLICSCDYDG--GSVHISKHPTQHNLFAMSLFGDRIFYS 262
++++ ++W G +S I DG + + K+ + A+ F +RI+++
Sbjct: 4032 IAVNPKRGMMYWTVV---GDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWA 4088
Query: 263 TWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTW--EPEQKLCKL 320
+++ I +V ++ + ++HP ED + P+ + ++
Sbjct: 4089 DFELSIIGSVLYDGSNSVVSVS--------SKQGLLHPHRIDIFEDYIYGAGPKNGVFRV 4140
Query: 321 RK-GNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYY 379
+K G+ S ++ +G +S K + N C + C C P
Sbjct: 4141 QKFGHGSVEYLALNIDK-----TKGVLISHRYKQLDLPNPCL--DLACEFLCLLNPSGAT 4193
Query: 380 CTCPVGFVLLPDGKRCHQLV--SCPRNVSECSHDCVLTSEGPL-CFC-PEGSVLERDGKT 435
C CP G L+ L+ SC + E C+L +G L C C P S +
Sbjct: 4194 CVCPEGKYLINGTCNDDSLLDDSC-KLTCENGGRCILNEKGDLRCHCWPSYSGERCEVNH 4252
Query: 436 CSGCSSPDNGGCSQLCVPLSPVSWECDCFPGY 467
CS NGG CVP C C G+
Sbjct: 4253 CSNYC--QNGG---TCVPSVLGRPTCSCALGF 4279
Score = 43.1 bits (100), Expect = 0.002
Identities = 24/64 (37%), Positives = 32/64 (50%), Gaps = 6/64 (9%)
Query: 887 KCINTEGGYVCRCSEGYQ--GDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMCA-GR 943
KC C C +G++ DG C D DEC + +C + +C NT G YTC C G
Sbjct: 128 KCTMVRNSTRCYCEDGFEITEDGRSCKDQDECAV-YGTCSQ--TCRNTHGSYTCSCVEGY 184
Query: 944 LSEP 947
L +P
Sbjct: 185 LMQP 188
Score = 40.0 bits (92), Expect = 0.013
Identities = 36/141 (25%), Positives = 52/141 (36%), Gaps = 25/141 (17%)
Query: 830 SDQDDCAPVGCSMYARCISEGEDATCQCLKGFAGDGKLCSDIDEC-----EMGVPVCPPA 884
SD+D C G Y + ++ C K D + C +D+C E G + P
Sbjct: 3746 SDEDHCG--GKLTYKARPCKKDEFACSNKKCIPMDLQ-CDRLDDCGDGSDEQGCRIAPTE 3802
Query: 885 ------------SSKCINTEGGYVCRCSEGYQGD--GIHCLDIDECQLGEHSCGENASCT 930
+ C + CRC G+Q + C D++EC L +C C
Sbjct: 3803 YTCEDNVNPCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNEC-LVFGTCSHQ--CI 3859
Query: 931 NTEGGYTCMCAGRLSEPGLIC 951
N EG Y C+C E C
Sbjct: 3860 NVEGSYKCVCDQNFQERNNTC 3880
Score = 33.1 bits (74), Expect = 1.6
Identities = 12/33 (36%), Positives = 18/33 (54%)
Query: 750 GGCEHICKKRLGTAWCSCREGFMKASDGKTCLA 782
G C C+ G+ CSC EG++ D ++C A
Sbjct: 163 GTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKA 195
Score = 31.6 bits (70), Expect = 4.8
Identities = 13/34 (38%), Positives = 17/34 (50%)
Query: 751 GCEHICKKRLGTAWCSCREGFMKASDGKTCLALD 784
GC C+ + C C GF DGKTC+ +D
Sbjct: 2937 GCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDID 2970
Score = 30.8 bits (68), Expect = 8.1
Identities = 13/33 (39%), Positives = 17/33 (51%), Gaps = 1/33 (3%)
Query: 323 GNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCE 355
G CS T C S+ C C EGY + D + C+
Sbjct: 163 GTCSQT-CRNTHGSYTCSCVEGYLMQPDNRSCK 194
Score = 30.8 bits (68), Expect = 8.1
Identities = 20/81 (24%), Positives = 33/81 (40%), Gaps = 16/81 (19%)
Query: 401 CPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSG---------CSSPDNGGCSQLC 451
C N CS C+ G +C C + +L+ +G TC+ C + + ++ C
Sbjct: 798 CRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFNPGEALPHICKAGEFRCKNRHC 857
Query: 452 VPLSPVSWEC----DCFPGYD 468
+ W+C DC G D
Sbjct: 858 I---QARWKCDGDDDCLDGSD 875
>gi|65301164 very low density lipoprotein receptor isoform b [Homo
sapiens]
Length = 845
Score = 217 bits (552), Expect = 6e-56
Identities = 146/489 (29%), Positives = 231/489 (47%), Gaps = 43/489 (8%)
Query: 324 NCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNT-----PGSY 378
NC S C D C +G + R+ C + +C + + CKN PG +
Sbjct: 272 NCPSRTCRPDQFE----CEDGSCIHGSRQ-CNGIRDCV--DGSDEVNCKNVNQCLGPGKF 324
Query: 379 YCTC----PVGFVLLPDG----------KRCHQLVSCPRNVSECSHDCVLTSEGPLCFCP 424
C + V + K CH + C N CSH C G C C
Sbjct: 325 KCRSGECIDISKVCNQEQDCRDWSDEPLKECH-INECLVNNGGCSHICKDLVIGYECDCA 383
Query: 425 EGSVLERDGKTCSGCSSPDNGG-CSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQP 483
G L D KTC N G CSQ+C+ L ++C+C GY + L C A G +P
Sbjct: 384 AGFELI-DRKTCGDIDECQNPGICSQICINLKG-GYKCECSRGYQMDLATGVCKAVGKEP 441
Query: 484 FLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDG 543
L+F N +DIR + + +Y L+ Q V ALD D K+++A + K I A++D
Sbjct: 442 SLIFTNRRDIRKIGLERKEYIQLVEQLRNTV-ALDADIAAQKLFWADLSQKAIFSASIDD 500
Query: 544 SQ-RERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRG 602
R + + V P +AVDW+ + YWTD I + L+G + K + ++ +P
Sbjct: 501 KVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPAS 560
Query: 603 IAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAK 662
IAV P++ ++W+D G +IE + + G R + ++D+ WP+GIT+D + +LYW D+K
Sbjct: 561 IAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSK 620
Query: 663 QSVIEMANLDGSKRRRLTQN--DVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVR 720
++ +L+G RR + ++ + HP A+ +FED V++ D +V NK TG +
Sbjct: 621 LHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELAT 680
Query: 721 LQGSMLKPSSLVVVHPLAKP-GADPCL--YQNGGCEHIC------KKRLGTAWCSCREGF 771
L ++ ++V H L +P G + C +NGGCE++C CSC G+
Sbjct: 681 LVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGY 740
Query: 772 MKASDGKTC 780
+G+ C
Sbjct: 741 NVEENGRDC 749
Score = 108 bits (270), Expect = 3e-23
Identities = 82/360 (22%), Positives = 160/360 (44%), Gaps = 36/360 (10%)
Query: 18 VSLSAPQHWSCPEGTLAGNGNSTC--VGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGV 75
++L C G C VG P LIF++ I +I E Y QLV
Sbjct: 411 INLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRN 470
Query: 76 SVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEK--NVSGMAINWINEEVIWS 133
+V +D ++++W DL ++ + ++ V I+ N + +A++W+ + + W+
Sbjct: 471 TVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWT 530
Query: 134 NQQEGIITVTDMKGNNSHILL-SALKYPANVAVDPVERFIFWSS-EVAGSLYRADLDGVG 191
+ I+V + G L S L+ PA++AVDP+ F++WS + +A ++G
Sbjct: 531 DAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFD 590
Query: 192 VKALLETS-EKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDG-------GSVHISKH 243
+ L+ + ++LD++ RL+W+ + ++ S D +G S+ H
Sbjct: 591 RRPLVTADIQWPNGITLDLIKSRLYWL----DSKLHMLSSVDLNGQDRRIVLKSLEFLAH 646
Query: 244 PTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQ 303
P A+++F DR+++ + + ++ ANK TG ++ L ++ ++ V H L Q
Sbjct: 647 P-----LALTIFEDRVYWIDGENEAVYGANKFTGSELA--TLVNNLNDAQDIIVYHELVQ 699
Query: 304 PKAEDDTWEPEQKLCKLRKGNCS-----STVCGQDLQSHLCMCAEGYALSRDRKYCEDVN 358
P ++ W E + G C + + C C GY + + + C+ +N
Sbjct: 700 PSGKN--WCEED----MENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQRIN 753
Score = 53.5 bits (127), Expect = 1e-06
Identities = 31/69 (44%), Positives = 37/69 (53%), Gaps = 7/69 (10%)
Query: 839 GCSMYARCISEGEDATCQCLKGFAG-DGKLCSDIDECEMGVPVCPPASSKCINTEGGYVC 897
GCS + + G + C C GF D K C DIDEC+ +C S CIN +GGY C
Sbjct: 366 GCSHICKDLVIGYE--CDCAAGFELIDRKTCGDIDECQ-NPGIC---SQICINLKGGYKC 419
Query: 898 RCSEGYQGD 906
CS GYQ D
Sbjct: 420 ECSRGYQMD 428
Score = 42.7 bits (99), Expect = 0.002
Identities = 35/124 (28%), Positives = 52/124 (41%), Gaps = 21/124 (16%)
Query: 833 DDCAPVGCSMYARCISEGEDATCQCLKGFAGD-GKLCSDIDECE--MGVPVCPPASSKCI 889
D V C +C+ G+ +C G D K+C+ +C P+ ++C+
Sbjct: 305 DGSDEVNCKNVNQCLGPGK---FKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECL 361
Query: 890 NTEGG-----------YVCRCSEGYQG-DGIHCLDIDECQLGEHSCGENASCTNTEGGYT 937
GG Y C C+ G++ D C DIDECQ C + C N +GGY
Sbjct: 362 VNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQ-NPGICSQ--ICINLKGGYK 418
Query: 938 CMCA 941
C C+
Sbjct: 419 CECS 422
Score = 41.6 bits (96), Expect = 0.005
Identities = 21/49 (42%), Positives = 26/49 (53%), Gaps = 1/49 (2%)
Query: 736 PLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALD 784
PL + + CL NGGC HICK + C C GF + D KTC +D
Sbjct: 351 PLKECHINECLVNNGGCSHICKDLVIGYECDCAAGF-ELIDRKTCGDID 398
>gi|65301167 very low density lipoprotein receptor isoform a [Homo
sapiens]
Length = 873
Score = 217 bits (552), Expect = 6e-56
Identities = 146/489 (29%), Positives = 231/489 (47%), Gaps = 43/489 (8%)
Query: 324 NCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNT-----PGSY 378
NC S C D C +G + R+ C + +C + + CKN PG +
Sbjct: 272 NCPSRTCRPDQFE----CEDGSCIHGSRQ-CNGIRDCV--DGSDEVNCKNVNQCLGPGKF 324
Query: 379 YCTC----PVGFVLLPDG----------KRCHQLVSCPRNVSECSHDCVLTSEGPLCFCP 424
C + V + K CH + C N CSH C G C C
Sbjct: 325 KCRSGECIDISKVCNQEQDCRDWSDEPLKECH-INECLVNNGGCSHICKDLVIGYECDCA 383
Query: 425 EGSVLERDGKTCSGCSSPDNGG-CSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQP 483
G L D KTC N G CSQ+C+ L ++C+C GY + L C A G +P
Sbjct: 384 AGFELI-DRKTCGDIDECQNPGICSQICINLKG-GYKCECSRGYQMDLATGVCKAVGKEP 441
Query: 484 FLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDG 543
L+F N +DIR + + +Y L+ Q V ALD D K+++A + K I A++D
Sbjct: 442 SLIFTNRRDIRKIGLERKEYIQLVEQLRNTV-ALDADIAAQKLFWADLSQKAIFSASIDD 500
Query: 544 SQ-RERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRG 602
R + + V P +AVDW+ + YWTD I + L+G + K + ++ +P
Sbjct: 501 KVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPAS 560
Query: 603 IAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAK 662
IAV P++ ++W+D G +IE + + G R + ++D+ WP+GIT+D + +LYW D+K
Sbjct: 561 IAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSK 620
Query: 663 QSVIEMANLDGSKRRRLTQN--DVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVR 720
++ +L+G RR + ++ + HP A+ +FED V++ D +V NK TG +
Sbjct: 621 LHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELAT 680
Query: 721 LQGSMLKPSSLVVVHPLAKP-GADPCL--YQNGGCEHIC------KKRLGTAWCSCREGF 771
L ++ ++V H L +P G + C +NGGCE++C CSC G+
Sbjct: 681 LVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGY 740
Query: 772 MKASDGKTC 780
+G+ C
Sbjct: 741 NVEENGRDC 749
Score = 105 bits (263), Expect = 2e-22
Identities = 81/357 (22%), Positives = 158/357 (44%), Gaps = 36/357 (10%)
Query: 18 VSLSAPQHWSCPEGTLAGNGNSTC--VGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGV 75
++L C G C VG P LIF++ I +I E Y QLV
Sbjct: 411 INLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRN 470
Query: 76 SVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEK--NVSGMAINWINEEVIWS 133
+V +D ++++W DL ++ + ++ V I+ N + +A++W+ + + W+
Sbjct: 471 TVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWT 530
Query: 134 NQQEGIITVTDMKGNNSHILL-SALKYPANVAVDPVERFIFWSS-EVAGSLYRADLDGVG 191
+ I+V + G L S L+ PA++AVDP+ F++WS + +A ++G
Sbjct: 531 DAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFD 590
Query: 192 VKALLETS-EKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDG-------GSVHISKH 243
+ L+ + ++LD++ RL+W+ + ++ S D +G S+ H
Sbjct: 591 RRPLVTADIQWPNGITLDLIKSRLYWL----DSKLHMLSSVDLNGQDRRIVLKSLEFLAH 646
Query: 244 PTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQ 303
P A+++F DR+++ + + ++ ANK TG ++ L ++ ++ V H L Q
Sbjct: 647 P-----LALTIFEDRVYWIDGENEAVYGANKFTGSELA--TLVNNLNDAQDIIVYHELVQ 699
Query: 304 PKAEDDTWEPEQKLCKLRKGNCS-----STVCGQDLQSHLCMCAEGYALSRDRKYCE 355
P ++ W E + G C + + C C GY + + + C+
Sbjct: 700 PSGKN--WCEED----MENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQ 750
Score = 53.5 bits (127), Expect = 1e-06
Identities = 31/69 (44%), Positives = 37/69 (53%), Gaps = 7/69 (10%)
Query: 839 GCSMYARCISEGEDATCQCLKGFAG-DGKLCSDIDECEMGVPVCPPASSKCINTEGGYVC 897
GCS + + G + C C GF D K C DIDEC+ +C S CIN +GGY C
Sbjct: 366 GCSHICKDLVIGYE--CDCAAGFELIDRKTCGDIDECQ-NPGIC---SQICINLKGGYKC 419
Query: 898 RCSEGYQGD 906
CS GYQ D
Sbjct: 420 ECSRGYQMD 428
Score = 42.7 bits (99), Expect = 0.002
Identities = 35/124 (28%), Positives = 52/124 (41%), Gaps = 21/124 (16%)
Query: 833 DDCAPVGCSMYARCISEGEDATCQCLKGFAGD-GKLCSDIDECE--MGVPVCPPASSKCI 889
D V C +C+ G+ +C G D K+C+ +C P+ ++C+
Sbjct: 305 DGSDEVNCKNVNQCLGPGK---FKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECL 361
Query: 890 NTEGG-----------YVCRCSEGYQG-DGIHCLDIDECQLGEHSCGENASCTNTEGGYT 937
GG Y C C+ G++ D C DIDECQ C + C N +GGY
Sbjct: 362 VNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQ-NPGICSQ--ICINLKGGYK 418
Query: 938 CMCA 941
C C+
Sbjct: 419 CECS 422
Score = 41.6 bits (96), Expect = 0.005
Identities = 21/49 (42%), Positives = 26/49 (53%), Gaps = 1/49 (2%)
Query: 736 PLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALD 784
PL + + CL NGGC HICK + C C GF + D KTC +D
Sbjct: 351 PLKECHINECLVNNGGCSHICKDLVIGYECDCAAGF-ELIDRKTCGDID 398
>gi|115298674 nidogen 1 precursor [Homo sapiens]
Length = 1247
Score = 164 bits (415), Expect = 5e-40
Identities = 128/469 (27%), Positives = 205/469 (43%), Gaps = 55/469 (11%)
Query: 336 SHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRC 395
S+ C C G+ S D + C+DV+EC C NTPGS+ C C G+ DG RC
Sbjct: 784 SYTCSCLPGF--SGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQ--GDGFRC 839
Query: 396 HQLVSCPRNVSECSHDC--VLTSEG---------PLCFCPE-------------GSV--- 428
V + C H+ +L + G P F PE GS
Sbjct: 840 ---VPGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYC 896
Query: 429 --LERDGKTCSGCSSPDNGGCSQLCVP-LSPVSWECDCFPGYDLQLDEKSCAASGPQPFL 485
++RDG+ G + G + C+ ++P + P + L P L
Sbjct: 897 WCVDRDGREVEGTRT--RPGMTPPCLSTVAPPIHQGPAVPTAVIPLP--------PGTHL 946
Query: 486 LFANSQDIRHMHFDG-----TDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERAN 540
LFA + I + +G T+ L ++ L D V+ +Y+ I RA+
Sbjct: 947 LFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRAS 1006
Query: 541 MDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQP 600
+ G + +I + + PEG+AVD +GR +WTD I + L+G + +++ + ++ P
Sbjct: 1007 LHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNP 1066
Query: 601 RGIAVHPMAKRLFWTD-TGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWC 659
RGI + L+WTD NP+IE+S + G R ++ DL P+G+T D + +L W
Sbjct: 1067 RGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWV 1126
Query: 660 DAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRV 719
DA + E N RR+ + + +PFAV + ++F+DW M SV+ ++ K+
Sbjct: 1127 DAGTNRAECLNPSQPSRRKALEG-LQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETD 1185
Query: 720 RLQ-GSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHICKKRLGTAWCSC 767
Q + + G + C NGGC H+C G+ C C
Sbjct: 1186 AFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRC 1234
Score = 78.6 bits (192), Expect = 3e-14
Identities = 68/234 (29%), Positives = 89/234 (38%), Gaps = 61/234 (26%)
Query: 743 DPCLYQNGGC--EHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQV 800
D C Q C IC GT C C EG+ + +G TC+A+ + + E L N
Sbjct: 712 DECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEG-TCVAVVDQRPINYCETGLHNCD 770
Query: 801 TPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCI-SEGEDATCQCLK 859
P A+CI + G TC CL
Sbjct: 771 IP---------------------------------------QRAQCIYTGGSSYTCSCLP 791
Query: 860 GFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHC----LDIDE 915
GF+GDG+ C D+DEC+ C P + C NT G + C+C GYQGDG C ++
Sbjct: 792 GFSGDGQACQDVDECQPS--RCHP-DAFCYNTPGSFTCQCKPGYQGDGFRCVPGEVEKTR 848
Query: 916 CQ-LGEHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHLREDDHHYS 968
CQ EH G A T+ + R PGL P+ H H S
Sbjct: 849 CQHEREHILGA-AGATDPQ---------RPIPPGLFVPECDAHGHYAPTQCHGS 892
Score = 76.6 bits (187), Expect = 1e-13
Identities = 61/187 (32%), Positives = 74/187 (39%), Gaps = 38/187 (20%)
Query: 839 GCSMYARCI-SEGEDATCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVC 897
GC A C TC+C GF GDG+ C DIDEC VC + + C N G + C
Sbjct: 678 GCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVC-GSHTICNNHPGTFRC 736
Query: 898 RCSEGYQ----GDGIHCLD---IDECQLGEHSCG--ENASCTNTEG-GYTCMCAGRLSEP 947
C EGYQ G + +D I+ C+ G H+C + A C T G YTC C S
Sbjct: 737 ECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGFSGD 796
Query: 948 GLICPDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGY 1007
G C D EC S C D C + C C GY
Sbjct: 797 GQACQDV-------------------DECQPSR---CHPDAFC--YNTPGSFTCQCKPGY 832
Query: 1008 IGE--RC 1012
G+ RC
Sbjct: 833 QGDGFRC 839
Score = 76.6 bits (187), Expect = 1e-13
Identities = 104/410 (25%), Positives = 153/410 (37%), Gaps = 67/410 (16%)
Query: 339 CMCAEGYALSRDRKYCEDVNECAFWNHGCTLG--CKNTPGSYYCTCPVGFVLLPDGKRCH 396
C C+ G+ D + C D++EC+ C C N PG++ C C G+ +G
Sbjct: 695 CECSIGFR--GDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGTCVA 752
Query: 397 QLVSCPRNVSECS-HDCVLTSEGP---------LCFCPEGSVLERDGKTCSGCSSPDNGG 446
+ P N E H+C + C C G DG+ C
Sbjct: 753 VVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPG--FSGDGQACQDVDECQPSR 810
Query: 447 C--SQLCVPLSPVSWECDCFPGYD--------LQLDEKSC-----------AASGPQ--- 482
C C +P S+ C C PGY ++++ C A+ PQ
Sbjct: 811 CHPDAFCYN-TPGSFTCQCKPGYQGDGFRCVPGEVEKTRCQHEREHILGAAGATDPQRPI 869
Query: 483 PFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMD 542
P LF D H H+ T G + +D D E + T R M
Sbjct: 870 PPGLFVPECD-AHGHYAPTQ----CHGSTGYCWCVDRDGRE--VEGTRT------RPGMT 916
Query: 543 G---SQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGK-RSKIITKENIS 598
S I +G VP + G + GK I R L G K K +
Sbjct: 917 PPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGK--IERLPLEGNTMRKTEAKAFLH 974
Query: 599 QPR----GIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTD 654
P G+A + K ++WTD P I +SL G I DL P GI +D L
Sbjct: 975 VPAKVIIGLAFDCVDKMVYWTDI-TEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGR 1033
Query: 655 KLYWCDAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAV--FEDYVWFSDW 702
++W D+ IE+A LDG++RR L + D+ +P + ++++DW
Sbjct: 1034 NIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDW 1083
Score = 68.9 bits (167), Expect = 3e-11
Identities = 70/351 (19%), Positives = 136/351 (38%), Gaps = 68/351 (19%)
Query: 44 PAPFLIFSHGNSIFRIDTEGTNYEQ------LVVDAGVSVIMDFHYNEKRIYWVDLERQL 97
P L+F+ I R+ EG + L V A V + + F +K +YW D+
Sbjct: 942 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS 1001
Query: 98 LQRVFLNGSRQERVCNIE-KNVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSA 156
+ R L+G + + + G+A++ + + W++ I V + G +L
Sbjct: 1002 IGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFET 1061
Query: 157 -LKYPANVAVDPVERFIFWS--SEVAGSLYRADLDGVGVKALLETSEKI-TAVSLDVLDK 212
L P + D V ++W+ + + + +DG + L++ + ++ D
Sbjct: 1062 DLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSS 1121
Query: 213 RLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIA 272
+L W+ + L S ++ ++P FA++ +G ++++ WKM ++
Sbjct: 1122 QLCWVDAGTNRAECLNPSQPSRRKALEGLQYP-----FAVTSYGKNLYFTDWKMNSV--- 1173
Query: 273 NKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQ 332
V ++L S E D ++P ++ + + G
Sbjct: 1174 --------VALDLAIS-----------------KETDAFQPHKQ----------TRLYG- 1197
Query: 333 DLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCP 383
+ + L C +G+ N C+ N GCT C TPGS C CP
Sbjct: 1198 -ITTALSQCPQGH------------NYCSVNNGGCTHLCLATPGSRTCRCP 1235
Score = 58.2 bits (139), Expect = 5e-08
Identities = 36/141 (25%), Positives = 56/141 (39%), Gaps = 20/141 (14%)
Query: 874 CEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCLDIDECQLGEHSCGENASCTNTE 933
C +G C ++ + C CS G++GDG C DIDEC CG + C N
Sbjct: 672 CYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHP 731
Query: 934 GGYTCMCAG--RLSEPG--LICPDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCLHDGV 989
G + C C + S+ G + D P + H+ C + C++ G
Sbjct: 732 GTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHN---------CDIPQRAQCIYTGG 782
Query: 990 CMYIEALDKYACNCVVGYIGE 1010
Y C+C+ G+ G+
Sbjct: 783 -------SSYTCSCLPGFSGD 796
Score = 45.1 bits (105), Expect = 4e-04
Identities = 35/131 (26%), Positives = 44/131 (33%), Gaps = 28/131 (21%)
Query: 358 NECAFWNHGCTLGCKNTPG---SYYCTCPVGFVLLPDGKRCHQLVSCPRNVSEC-SHDCV 413
N C HGC PG + C C +GF DG+ C+ + C S C SH
Sbjct: 670 NPCYIGTHGCDTNAACRPGPRTQFTCECSIGF--RGDGRTCYDIDECSEQPSVCGSHTIC 727
Query: 414 LTSEGPL-CFCPEGSVLERDGKTC----------------SGCSSPDNGGCSQLCVPLSP 456
G C C EG +G TC C P C+
Sbjct: 728 NNHPGTFRCECVEGYQFSDEG-TCVAVVDQRPINYCETGLHNCDIPQRA----QCIYTGG 782
Query: 457 VSWECDCFPGY 467
S+ C C PG+
Sbjct: 783 SSYTCSCLPGF 793
Score = 30.8 bits (68), Expect = 8.1
Identities = 10/29 (34%), Positives = 16/29 (55%)
Query: 840 CSMYARCISEGEDATCQCLKGFAGDGKLC 868
CS++A C C C+ G+ G+G+ C
Sbjct: 397 CSVHAECRDYATGFCCSCVAGYTGNGRQC 425
>gi|144953895 nidogen 2 precursor [Homo sapiens]
Length = 1375
Score = 145 bits (366), Expect = 2e-34
Identities = 82/240 (34%), Positives = 134/240 (55%), Gaps = 8/240 (3%)
Query: 484 FLLFANSQDIRHMHFDGTDYG-----TLLSQQMGMVYALDHDPVENKIYFAHTALKWIER 538
FLL+ Q I ++ +GT TLLS ++ +D+D E +Y+ A + I R
Sbjct: 1109 FLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVAGRTISR 1168
Query: 539 ANMD-GSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENI 597
A ++ G++ E ++ G+ PEGLA+D I R YWTD I + L+G K++ ++
Sbjct: 1169 AGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDL 1228
Query: 598 SQPRGIAVHPMAKRLFWTDTGIN-PRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKL 656
PR IAV P+ L+WTD P+IE+SSL G R ++ ++D+ P+G+T D + L
Sbjct: 1229 VNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLL 1288
Query: 657 YWCDAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGK 716
W DA +E DG+ RR+ QN++ +PF++ + D+ + +DW V+ VNK +G+
Sbjct: 1289 CWADAGTKKLECTLPDGT-GRRVIQNNLKYPFSIVSYADHFYHTDWRRDGVVSVNKHSGQ 1347
Score = 81.3 bits (199), Expect = 5e-15
Identities = 53/168 (31%), Positives = 64/168 (38%), Gaps = 55/168 (32%)
Query: 840 CSMYARCI-SEGEDATCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCR 898
C ARC G D TC+C G+ GDG+ C D +EC G C P +S CIN G Y C
Sbjct: 770 CDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCGP-NSVCINLPGSYRCE 828
Query: 899 CSEGYQ--------------------------------------------------GDGI 908
C GY+ GDG
Sbjct: 829 CRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYAGDGH 888
Query: 909 HCLDIDECQLGEHSCGENASCTNTEGGYTCMCAGRLSEPGLIC-PDST 955
C D+DEC E+ C A+C NT G ++C C G C PDST
Sbjct: 889 QCTDVDEC--SENRCHPAATCYNTPGSFSCRCQPGYYGDGFQCIPDST 934
Score = 81.3 bits (199), Expect = 5e-15
Identities = 64/236 (27%), Positives = 85/236 (36%), Gaps = 71/236 (30%)
Query: 751 GCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLDILSKTR 810
G +C G+ C CR G+ A D TC+ +TP
Sbjct: 813 GPNSVCINLPGSYRCECRSGYEFADDRHTCIL-----------------ITP-----PAN 850
Query: 811 VSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDA-TCQCLKGFAGDGKLCS 869
ED CAP G ARC+ G +C CL G+AGDG C+
Sbjct: 851 PCEDG----------------SHTCAPAG---QARCVHHGGSTFSCACLPGYAGDGHQCT 891
Query: 870 DIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCL-----DIDECQLGEH--- 921
D+DEC C PA++ C NT G + CRC GY GDG C+ + C+ +
Sbjct: 892 DVDECSEN--RCHPAAT-CYNTPGSFSCRCQPGYYGDGFQCIPDSTSSLTPCEQQQRHAQ 948
Query: 922 -------------SCGENAS-----CTNTEGGYTCMCAGRLSEPGLICPDSTPPPH 959
C E + C + G C+ PG P + PPH
Sbjct: 949 AQYAYPGARFHIPQCDEQGNFLPLQCHGSTGFCWCVDPDGHEVPGTQTPPGSTPPH 1004
Score = 80.5 bits (197), Expect = 9e-15
Identities = 46/146 (31%), Positives = 63/146 (43%), Gaps = 17/146 (11%)
Query: 874 CEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCLDIDECQLGEHSCGENASCTNTE 933
C G +C + T Y C C+ GYQGDG +C+D +EC G H CG N+ C N
Sbjct: 763 CYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCGPNSVCINLP 822
Query: 934 GGYTCMCAG--RLSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCLHDGVCM 991
G Y C C ++ C TPP + ED H C + C+H G
Sbjct: 823 GSYRCECRSGYEFADDRHTCILITPPANPCEDGSH--------TCAPAGQARCVHHGG-- 872
Query: 992 YIEALDKYACNCVVGYIGERCQYRDL 1017
++C C+ GY G+ Q D+
Sbjct: 873 -----STFSCACLPGYAGDGHQCTDV 893
Score = 70.1 bits (170), Expect = 1e-11
Identities = 57/247 (23%), Positives = 111/247 (44%), Gaps = 23/247 (9%)
Query: 47 FLIFSHGNSIFRIDTEGTNYEQ------LVVDAGVSVIMDFHYNEKRIYWVDLERQLLQR 100
FL+++ G I + GT ++ L + + V +D+ E+ +YW D+ + + R
Sbjct: 1109 FLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVAGRTISR 1168
Query: 101 VFLN-GSRQERVCNIEK-NVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILL-SAL 157
L G+ E + N + G+AI+ I + W++ I + G+ +L + L
Sbjct: 1169 AGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDL 1228
Query: 158 KYPANVAVDPVERFIFWS--SEVAGSLYRADLDGVGVKALLETSEKI-TAVSLDVLDKRL 214
P +AVDP+ ++W+ + A + + LDG + L+ T + ++ D K L
Sbjct: 1229 VNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLL 1288
Query: 215 FWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNL---FAMSLFGDRIFYSTWKMKTIWI 271
W G+ L C+ G + Q+NL F++ + D +++ W+ +
Sbjct: 1289 CWAD---AGTKKLECTLPDGTG-----RRVIQNNLKYPFSIVSYADHFYHTDWRRDGVVS 1340
Query: 272 ANKHTGK 278
NKH+G+
Sbjct: 1341 VNKHSGQ 1347
Score = 59.3 bits (142), Expect = 2e-08
Identities = 46/144 (31%), Positives = 55/144 (38%), Gaps = 18/144 (12%)
Query: 337 HLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLG--CKNTPGSYYCTCPVGFVLLPDGKR 394
+ C CA GY D + C D NECA H C C N PGSY C C G+ D
Sbjct: 784 YTCECASGY--QGDGRNCVDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHT 841
Query: 395 CHQLVSCPRNVSE-CSHDCVLTSEGPL---------CFCPEGSVLERDGKTCSGCSSPDN 444
C L++ P N E SH C + C C G DG C+
Sbjct: 842 C-ILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPG--YAGDGHQCTDVDECSE 898
Query: 445 GGCSQLCVPL-SPVSWECDCFPGY 467
C +P S+ C C PGY
Sbjct: 899 NRCHPAATCYNTPGSFSCRCQPGY 922
Score = 40.4 bits (93), Expect = 0.010
Identities = 36/132 (27%), Positives = 48/132 (36%), Gaps = 13/132 (9%)
Query: 327 STVCGQDLQSHLCMCAEGYALSRDRKYC----EDVNECAFWNHGCT----LGCKNTPGS- 377
++VC S+ C C GY + DR C N C +H C C + GS
Sbjct: 815 NSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGST 874
Query: 378 YYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCS 437
+ C C G+ DG +C + C N + C T C C G DG C
Sbjct: 875 FSCACLPGYA--GDGHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPG--YYGDGFQCI 930
Query: 438 GCSSPDNGGCSQ 449
S+ C Q
Sbjct: 931 PDSTSSLTPCEQ 942
Score = 30.8 bits (68), Expect = 8.1
Identities = 19/65 (29%), Positives = 29/65 (44%), Gaps = 7/65 (10%)
Query: 421 CFCPEGSVLERDGKTCSGCSSPDNG----GCSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
C C G + DG+ C + G G + +C+ L P S+ C+C GY+ D +C
Sbjct: 786 CECASG--YQGDGRNCVDENECATGFHRCGPNSVCINL-PGSYRCECRSGYEFADDRHTC 842
Query: 477 AASGP 481
P
Sbjct: 843 ILITP 847
>gi|32698824 low density lipoprotein receptor-related protein 5-like
[Homo sapiens]
Length = 252
Score = 135 bits (341), Expect = 2e-31
Identities = 76/239 (31%), Positives = 125/239 (52%), Gaps = 3/239 (1%)
Query: 522 VENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGR 581
+E +Y+ + I RA +DGS + LI ++ P+ +AV+W+ R YWT G I
Sbjct: 1 MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
Query: 582 SDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDL 641
+ LN KI+ E++ +PR IA+HP +W D G NP I+ ++L V+ ++ L
Sbjct: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
Query: 642 IWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSD 701
WP+G+ +D KLYW DAK IE ++D +KR+ L ++ + H F + D+++++
Sbjct: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTA 180
Query: 702 WAMPSVMRVNK-RTGKDRVRLQGSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHICKKR 759
W S+ RV+K + +D + Q L V V + G +P +NGG R
Sbjct: 181 WQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVV--GTNPHADRNGGAATCASSR 237
Score = 57.8 bits (138), Expect = 6e-08
Identities = 44/189 (23%), Positives = 86/189 (45%), Gaps = 8/189 (4%)
Query: 85 EKRIYWVDLERQLLQRVFLNGSRQERVCNIEKN-VSGMAINWINEEVIWSNQQEGIITVT 143
E +YW D E ++R +L+GS + + N + N +A+NW+ + W++ I VT
Sbjct: 2 EGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVT 61
Query: 144 DMKGNNSHILLSA-LKYPANVAVDPVERFIFWSSEVAG-SLYRADLDGVGVKALLETS-E 200
+ + IL+S + P +A+ P +W + RA+LD ++ L+ S
Sbjct: 62 CLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLG 121
Query: 201 KITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIF 260
++LD+ + +L+W + I + D ++F +L GD I+
Sbjct: 122 WPNGLALDLQEGKLYW----GDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIY 177
Query: 261 YSTWKMKTI 269
++ W+ +I
Sbjct: 178 WTAWQHHSI 186
>gi|209447022 low density lipoprotein receptor-related protein
5-like [Homo sapiens]
Length = 252
Score = 135 bits (341), Expect = 2e-31
Identities = 76/239 (31%), Positives = 125/239 (52%), Gaps = 3/239 (1%)
Query: 522 VENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGR 581
+E +Y+ + I RA +DGS + LI ++ P+ +AV+W+ R YWT G I
Sbjct: 1 MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
Query: 582 SDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDL 641
+ LN KI+ E++ +PR IA+HP +W D G NP I+ ++L V+ ++ L
Sbjct: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
Query: 642 IWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSD 701
WP+G+ +D KLYW DAK IE ++D +KR+ L ++ + H F + D+++++
Sbjct: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTA 180
Query: 702 WAMPSVMRVNK-RTGKDRVRLQGSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHICKKR 759
W S+ RV+K + +D + Q L V V + G +P +NGG R
Sbjct: 181 WQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVV--GTNPHADRNGGAATCASSR 237
Score = 57.8 bits (138), Expect = 6e-08
Identities = 44/189 (23%), Positives = 86/189 (45%), Gaps = 8/189 (4%)
Query: 85 EKRIYWVDLERQLLQRVFLNGSRQERVCNIEKN-VSGMAINWINEEVIWSNQQEGIITVT 143
E +YW D E ++R +L+GS + + N + N +A+NW+ + W++ I VT
Sbjct: 2 EGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVT 61
Query: 144 DMKGNNSHILLSA-LKYPANVAVDPVERFIFWSSEVAG-SLYRADLDGVGVKALLETS-E 200
+ + IL+S + P +A+ P +W + RA+LD ++ L+ S
Sbjct: 62 CLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLG 121
Query: 201 KITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIF 260
++LD+ + +L+W + I + D ++F +L GD I+
Sbjct: 122 WPNGLALDLQEGKLYW----GDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIY 177
Query: 261 YSTWKMKTI 269
++ W+ +I
Sbjct: 178 WTAWQHHSI 186
>gi|4507157 sortilin-related receptor containing LDLR class A repeats
preproprotein [Homo sapiens]
Length = 2214
Score = 123 bits (309), Expect = 9e-28
Identities = 125/478 (26%), Positives = 200/478 (41%), Gaps = 43/478 (8%)
Query: 476 CAASGPQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKW 535
C + F+L+A + I L + ALD D N +Y++ AL
Sbjct: 752 CPLAEENEFILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDV 811
Query: 536 IERANMDGSQ-RERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGK-RSKIIT 593
I+R ++GS +E +I G++ E LA + + + YW D G I ++ +G R I+
Sbjct: 812 IQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVN 871
Query: 594 KENISQPRGIAVHPMAKRLFWTDTG-INPRIESSSLQGLGRLVIASSDLIWPSGITIDFL 652
+ +PR + + P +FWTD G + P I S++ G + S D+ WP+GI++D
Sbjct: 872 SSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD-- 929
Query: 653 TDKLYWCDAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNK 712
+YW DA IE G +R + N + HP+A+AVF++ +++ DW+ S+ R +K
Sbjct: 930 DQWIYWTDAYLECIERITFSGQQRSVILDN-LPHPYAIAVFKNEIYWDDWSQLSIFRASK 988
Query: 713 RTGKDRVRLQGSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHIC-KKRLGTAWCSCREGF 771
+G L + + + + G++ C+ + C +C K + C C E
Sbjct: 989 YSGSQMEILANQLTGLMDMKIFYKGKNTGSNACVPR--PCSLLCLPKANNSRSCRCPEDV 1046
Query: 772 MKA---SDGKTCLALDGHQLLAGGEVDLKNQVTPLDILSKTRVSEDNITESQHMLVAEI- 827
+ S C G+QL V +N + ++ R S N S +
Sbjct: 1047 SSSVLPSGDLMCDCPQGYQLKNNTCVKEENTC----LRNQYRCSNGNCINSIWWCDFDND 1102
Query: 828 --MVSDQDDCAPVGCSM--YARCISEGEDATC-----QC-LKGFAGDGKLCSDIDECEMG 877
+SD+ +C C + RC E TC +C L+ GD SD CEM
Sbjct: 1103 CGDMSDERNCPTTICDLDTQFRC---QESGTCIPLSYKCDLEDDCGDN---SDESHCEM- 1155
Query: 878 VPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCLDIDE---CQLGEHSC-GENASCTN 931
S N G R S GD C D + C H+C N C N
Sbjct: 1156 ----HQCRSDEYNCSSGMCIRSSWVCDGDN-DCRDWSDEANCTAIYHTCEASNFQCRN 1208
Score = 93.2 bits (230), Expect = 1e-18
Identities = 109/463 (23%), Positives = 192/463 (41%), Gaps = 59/463 (12%)
Query: 47 FLIFSHGNSIFRIDTEGTNYEQL-VVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVFLNG 105
F++++ SI+R D EQL + +V +DF Y +YW DL ++QR+ LNG
Sbjct: 760 FILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCLNG 819
Query: 106 SR-QERVCNIE-KNVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILL--SALKYPA 161
S QE + N + V +A +++ + W + I V + G+ ++ S L P
Sbjct: 820 STGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPR 879
Query: 162 NVAVDPVERFIFWS--SEVAGSLYRADLDGVGVKALLETSEK-ITAVSLDVLDKRLFWIQ 218
+ + P E +FW+ ++ +YR+++DG L+ K +S+D D+ ++W
Sbjct: 880 ALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD--DQWIYWTD 937
Query: 219 YNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGK 278
E + S + HP +A+++F + I++ W +I+ A+K++G
Sbjct: 938 AYLECIERITFSGQQRSVILDNLPHP-----YAIAVFKNEIYWDDWSQLSIFRASKYSGS 992
Query: 279 DMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSH- 337
M L + L ++K+ + + P LC + N S C +D+ S
Sbjct: 993 QME--ILANQLTGLMDMKIFYKGKNTGSNACVPRPCSLLCLPKANNSRSCRCPEDVSSSV 1050
Query: 338 ------LCMCAEGYALSRDRKYCEDVNECAFWNHGCTLG-CKNTPGSYYC---------- 380
+C C +GY L ++ ++ N C + C+ G C N+ ++C
Sbjct: 1051 LPSGDLMCDCPQGYQL-KNNTCVKEENTCLRNQYRCSNGNCINS--IWWCDFDNDCGDMS 1107
Query: 381 ---TCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCS 437
CP L RC + +C S+ C L + C + S D C
Sbjct: 1108 DERNCPTTICDLDTQFRCQESGTC----IPLSYKCDLEDD-----CGDNS----DESHCE 1154
Query: 438 --GCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAA 478
C S + S +C+ SW CD DE +C A
Sbjct: 1155 MHQCRSDEYNCSSGMCI---RSSWVCDGDNDCRDWSDEANCTA 1194
>gi|66346695 fibrillin 2 precursor [Homo sapiens]
Length = 2912
Score = 122 bits (306), Expect = 2e-27
Identities = 78/269 (28%), Positives = 113/269 (42%), Gaps = 36/269 (13%)
Query: 743 DPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTP 802
D C+ NGGC+ C G+ CSC EG+ DG++C +D + D+ +
Sbjct: 1244 DECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECE----NNPDICDGGQC 1299
Query: 803 LDILSKTR-VSEDNITESQHMLVAEIMVSDQDDC-APVGCSMYARCISEGEDATCQCLKG 860
+I + R + D S M D ++C M+ C + C C G
Sbjct: 1300 TNIPGEYRCLCYDGFMASMDMKTC----IDVNECDLNSNICMFGECENTKGSFICHCQLG 1355
Query: 861 FAGDGKL--CSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCLDIDECQL 918
++ C+D+DECE+G C +S C+N G + C C EG+ G+GI C+D+DEC
Sbjct: 1356 YSVKKGTTGCTDVDECEIGAHNCDMHAS-CLNIPGSFKCSCREGWIGNGIKCIDLDECSN 1414
Query: 919 GEHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPL 978
G H C NA C NT G Y C C+ + G C D V L
Sbjct: 1415 GTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCSD---------------VDECAENINL 1459
Query: 979 SHDGYCLHDGVCMYIEALDKYACNCVVGY 1007
+G CL+ Y C C +G+
Sbjct: 1460 CENGQCLN--------VPGAYRCECEMGF 1480
Score = 97.1 bits (240), Expect = 9e-20
Identities = 55/163 (33%), Positives = 70/163 (42%), Gaps = 7/163 (4%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGS 377
CK+ C++ C + S C C GY C D++EC+ C CKNT GS
Sbjct: 2453 CKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGS 2512
Query: 378 YYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLER----DG 433
Y C+CP G+VL DGK C L C C CV T G C CP G D
Sbjct: 2513 YQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDN 2572
Query: 434 KTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
C S P G +C +P S+ C+C G+ L +C
Sbjct: 2573 NECG--SQPSLCGAKGIC-QNTPGSFSCECQRGFSLDATGLNC 2612
Score = 94.0 bits (232), Expect = 8e-19
Identities = 50/164 (30%), Positives = 73/164 (44%), Gaps = 7/164 (4%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGS 377
C L C + C + ++ C C GY + DR+ C D++EC N GC C N+ GS
Sbjct: 1204 CSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGS 1263
Query: 378 YYCTCPVGFVLLPDGKRCHQLVSCPRNVSEC-SHDCVLTSEGPLCFCPEGSVLERDGKTC 436
Y C+C G+ L+PDG+ C + C N C C C C +G + D KTC
Sbjct: 1264 YECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTC 1323
Query: 437 SGCSSPDNGGCSQLCV----PLSPVSWECDCFPGYDLQLDEKSC 476
+ D S +C+ + S+ C C GY ++ C
Sbjct: 1324 IDVNECDLN--SNICMFGECENTKGSFICHCQLGYSVKKGTTGC 1365
Score = 88.6 bits (218), Expect = 3e-17
Identities = 70/216 (32%), Positives = 95/216 (43%), Gaps = 35/216 (16%)
Query: 744 PCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPL 803
P + +NG C +I +G+ C C EGF +S G CL D Q L EV L
Sbjct: 2346 PGICENGRCVNI----IGSYRCECNEGFQSSSSGTECL--DNRQGLCFAEV--------L 2391
Query: 804 DILSKTRVSEDN-ITESQHMLVAEIMVSDQDDCAPV-GCSMYARCISEGEDATCQCLKGF 861
+ + S N +T+S+ Q + P+ G + Y + G G+
Sbjct: 2392 QTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGP--------GY 2443
Query: 862 AGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGD--GIHCLDIDECQLG 919
DG+ DIDEC++ +C + +CINT G + C C GY D G C+D+DEC
Sbjct: 2444 TTDGR---DIDECKVMPNLC--TNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQS 2498
Query: 920 EHSCGENASCTNTEGGYTCMCAGR--LSEPGLICPD 953
C N C NTEG Y C C L E G C D
Sbjct: 2499 PKPC--NYICKNTEGSYQCSCPRGYVLQEDGKTCKD 2532
Score = 87.0 bits (214), Expect = 1e-16
Identities = 54/168 (32%), Positives = 76/168 (45%), Gaps = 13/168 (7%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLG-CKNTPG 376
CK G C+ C + S C C G+AL + + C D++EC C G C NTPG
Sbjct: 1077 CKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPG 1136
Query: 377 SYYCTC----PVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPL-CFCPEGSVLER 431
S+ C C GF+++ K C + C RN C + +EG C CP G L
Sbjct: 1137 SFECECFEGYESGFMMM---KNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSP 1193
Query: 432 DGKTC---SGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
+ C + CS DN + CV + +++C C PGY D + C
Sbjct: 1194 SREDCVDINECSLSDNLCRNGKCVNMIG-TYQCSCNPGYQATPDRQGC 1240
Score = 87.0 bits (214), Expect = 1e-16
Identities = 64/215 (29%), Positives = 91/215 (42%), Gaps = 23/215 (10%)
Query: 745 CLYQNGGCEH-ICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPL 803
CL C H +C G+ C C GF + D C+ +D + G KN V
Sbjct: 1896 CLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECERHPCGNGTCKNTVGSY 1955
Query: 804 DILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMY--ARCISEGEDATCQCLKGF 861
+ L +T + L D D+C+ + RC +E C C +G+
Sbjct: 1956 NCLCYPGFE---LTHNNDCL-------DIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGY 2005
Query: 862 --AGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCLDIDECQLG 919
DGK C D +EC C P + C N EG + C C GY+ +C+DI+EC
Sbjct: 2006 ELTPDGKNCIDTNECVALPGSCSPGT--CQNLEGSFRCICPPGYEVKSENCIDINECDED 2063
Query: 920 EHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDS 954
+ C SCTNT GG+ C+C PG + D+
Sbjct: 2064 PNIC-LFGSCTNTPGGFQCLC-----PPGFVLSDN 2092
Score = 84.3 bits (207), Expect = 6e-16
Identities = 61/194 (31%), Positives = 85/194 (43%), Gaps = 34/194 (17%)
Query: 822 MLVAEIMVSDQDDC-APVGCSMYARCISEGEDATCQCLKGFAGD--GKLCSDIDECEMGV 878
+L D ++C A G Y +C + C+C GFA D + C+DIDEC +
Sbjct: 1064 VLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISP 1123
Query: 879 PVCPPASSKCINTEGGYVCRCSEGYQGDGI---HCLDIDECQLGEHSCGENASCTNTEGG 935
+C S C+NT G + C C EGY+ + +C+DIDEC+ C +C NTEG
Sbjct: 1124 DLC--GSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLC-RGGTCVNTEGS 1180
Query: 936 YTCMC--AGRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCLHDGVCMYI 993
+ C C LS C D +EC LS D C +G C +
Sbjct: 1181 FQCDCPLGHELSPSREDCVDI-------------------NECSLS-DNLC-RNGKC--V 1217
Query: 994 EALDKYACNCVVGY 1007
+ Y C+C GY
Sbjct: 1218 NMIGTYQCSCNPGY 1231
Score = 84.3 bits (207), Expect = 6e-16
Identities = 70/282 (24%), Positives = 115/282 (40%), Gaps = 44/282 (15%)
Query: 756 CKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLDILSKTRVSEDN 815
C+ +G+ C C GF + + C +D ++ DL ++
Sbjct: 1089 CRNTIGSFKCRCNSGFALDMEERNCTDIDECRI----SPDLCGSGICVNTPGSFECECFE 1144
Query: 816 ITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQCLKG--FAGDGKLCSDIDE 873
ES M++ M D+ + P+ C C++ C C G + + C DI+E
Sbjct: 1145 GYESGFMMMKNCMDIDECERNPLLC-RGGTCVNTEGSFQCDCPLGHELSPSREDCVDINE 1203
Query: 874 CEMGVPVCPPASSKCINTEGGYVCRCSEGYQG--DGIHCLDIDECQLGEHSCGENASCTN 931
C + +C + KC+N G Y C C+ GYQ D C DIDEC + C + CTN
Sbjct: 1204 CSLSDNLC--RNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGC--DTQCTN 1259
Query: 932 TEGGYTCMCAGRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSECP--------LSHDGY 983
+EG Y C C SE + PD + E +++ + + +C L +DG+
Sbjct: 1260 SEGSYECSC----SEGYALMPDGRSCADIDECENNPDICDG-GQCTNIPGEYRCLCYDGF 1314
Query: 984 C---------------LHDGVCMYIEALD---KYACNCVVGY 1007
L+ +CM+ E + + C+C +GY
Sbjct: 1315 MASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGY 1356
Score = 84.0 bits (206), Expect = 8e-16
Identities = 66/210 (31%), Positives = 89/210 (42%), Gaps = 24/210 (11%)
Query: 743 DPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTP 802
D C C +ICK G+ CSC G++ DGKTC LD Q Q
Sbjct: 2493 DECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHN-----CQFLC 2547
Query: 803 LDILSK-TRVSEDNITESQHMLVAEIMVSDQDDCA--PVGCSMYARCISEGEDATCQCLK 859
++ L T T+ + D ++C P C C + +C+C +
Sbjct: 2548 VNTLGGFTCKCPPGFTQHHTACI------DNNECGSQPSLCGAKGICQNTPGSFSCECQR 2601
Query: 860 GFAGD--GKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGY--QGDGIHCLDIDE 915
GF+ D G C D+DEC+ G C C N GGY C C +GY C+D +E
Sbjct: 2602 GFSLDATGLNCEDVDECD-GNHRCQHG---CQNILGGYRCGCPQGYIQHYQWNQCVDENE 2657
Query: 916 CQLGEHSCGENASCTNTEGGYTCMCAGRLS 945
C ++CG +ASC NT G Y C C S
Sbjct: 2658 CS-NPNACG-SASCYNTLGSYKCACPSGFS 2685
Score = 83.6 bits (205), Expect = 1e-15
Identities = 53/170 (31%), Positives = 74/170 (43%), Gaps = 20/170 (11%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTL--GCKNTP 375
C L C C S +C C GY++ + C DV+EC H C + C N P
Sbjct: 1329 CDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIP 1388
Query: 376 GSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECS--HDCVLTSEGPLCFCPEGSVLERDG 433
GS+ C+C G++ +G +C L C +CS CV T C C EG DG
Sbjct: 1389 GSFKCSCREGWI--GNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEG--FTGDG 1444
Query: 434 KTCSG---CSSP----DNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
TCS C+ +NG C + P ++ C+C G+ D +SC
Sbjct: 1445 FTCSDVDECAENINLCENGQCLNV-----PGAYRCECEMGFTPASDSRSC 1489
Score = 83.2 bits (204), Expect = 1e-15
Identities = 47/155 (30%), Positives = 70/155 (45%), Gaps = 4/155 (2%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGC--TLGCKNTP 375
CK G C++ VC + S C C G++ + CED++EC+ ++ C C N+P
Sbjct: 1812 CKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSP 1871
Query: 376 GSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPL-CFCPEGSVLERDGK 434
GSY C C GF L P+G C C + CSH + +G C C G +D
Sbjct: 1872 GSYRCECAAGFKLSPNG-ACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQT 1930
Query: 435 TCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDL 469
C + C + S+ C C+PG++L
Sbjct: 1931 MCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFEL 1965
Score = 82.0 bits (201), Expect = 3e-15
Identities = 50/162 (30%), Positives = 67/162 (41%), Gaps = 16/162 (9%)
Query: 325 CSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPV 384
C + C + S C C EG+ CED+NECA C C NT GSY CTCP+
Sbjct: 2223 CGNGTCTNVIGSFECNCNEGFEPG-PMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPI 2281
Query: 385 GFVLLPDGKRCHQLVSCPRNVSECSHD---CVLTSEGPLCFCPEGSVLERDGKTC---SG 438
G+ L D K C L C + +C C +C CP G DG+ C +
Sbjct: 2282 GYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENE 2341
Query: 439 CSSP----DNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
C + +NG C + S+ C+C G+ C
Sbjct: 2342 CRTKPGICENGRCVNII-----GSYRCECNEGFQSSSSGTEC 2378
Score = 81.6 bits (200), Expect = 4e-15
Identities = 56/168 (33%), Positives = 76/168 (45%), Gaps = 16/168 (9%)
Query: 317 LCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLG-CKNTP 375
+CK C + C + S+ C C GY + C DV+EC ++ CT G C NTP
Sbjct: 497 ICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGD-CIDVDECT--SNPCTNGDCVNTP 553
Query: 376 GSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHD-CVLTSEGPLCFCPEGSVLERDGK 434
GSYYC C GF P + C + C +N C + CV T C C G L DGK
Sbjct: 554 GSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGK 613
Query: 435 TC---SGCSSPD---NGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
C C++ + NG C S++C C PG+ L + + C
Sbjct: 614 NCVDHDECTTTNMCLNGMCIN-----EDGSFKCICKPGFVLAPNGRYC 656
Score = 79.7 bits (195), Expect = 2e-14
Identities = 57/184 (30%), Positives = 74/184 (40%), Gaps = 36/184 (19%)
Query: 831 DQDDCA--PVGCSMYARCISEGEDATCQCLKGFA--GDGKLCSDIDECEMGVPVCPPASS 886
D D+C+ P C+ C + C C +G+ DGK C D+DEC+ C
Sbjct: 2491 DLDECSQSPKPCNYI--CKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNC---QF 2545
Query: 887 KCINTEGGYVCRCSEGYQGDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMC--AGRL 944
C+NT GG+ C+C G+ C+D +EC CG C NT G ++C C L
Sbjct: 2546 LCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSL 2605
Query: 945 SEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCLHDGVCMYIEALDKYACNCV 1004
GL C D EC +H C H C I L Y C C
Sbjct: 2606 DATGLNCEDV-------------------DECDGNH--RCQHG--CQNI--LGGYRCGCP 2640
Query: 1005 VGYI 1008
GYI
Sbjct: 2641 QGYI 2644
Score = 79.0 bits (193), Expect = 3e-14
Identities = 46/132 (34%), Positives = 65/132 (49%), Gaps = 10/132 (7%)
Query: 325 CSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLG-CKNTPGSYYCTCP 383
C + C ++ S C+C EGY L+ D K C D NEC C+ G C+N GS+ C CP
Sbjct: 1985 CRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICP 2044
Query: 384 VGFVLLPDGKRCHQLVSCPRNVSECSH-DCVLTSEGPLCFCPEGSVLERDGKTC-----S 437
G+ + + C + C + + C C T G C CP G VL +G+ C S
Sbjct: 2045 PGYEV--KSENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQS 2102
Query: 438 GC-SSPDNGGCS 448
C ++ +NG CS
Sbjct: 2103 FCFTNFENGKCS 2114
Score = 75.5 bits (184), Expect = 3e-13
Identities = 46/145 (31%), Positives = 60/145 (41%), Gaps = 12/145 (8%)
Query: 329 VCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVL 388
+C S C C G++L CEDV+EC NH C GC+N G Y C CP G++
Sbjct: 2587 ICQNTPGSFSCECQRGFSLDATGLNCEDVDECD-GNHRCQHGCQNILGGYRCGCPQGYIQ 2645
Query: 389 LPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLER------DGKTCSGCSSP 442
+C C + S C T C CP G ++ D CS +P
Sbjct: 2646 HYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNP 2705
Query: 443 DNGGCSQLCVPLSPVSWECDCFPGY 467
N GCS + + C C PGY
Sbjct: 2706 CNYGCSN-----TEGGYLCGCPPGY 2725
Score = 73.6 bits (179), Expect = 1e-12
Identities = 38/109 (34%), Positives = 47/109 (43%)
Query: 330 CGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLL 389
C L + C C +GY C D NEC+ N + C NT GSY C CP GF
Sbjct: 2628 CQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGFSFD 2687
Query: 390 PDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSG 438
CH + C + + C++ C T G LC CP G G SG
Sbjct: 2688 QFSSACHDVNECSSSKNPCNYGCSNTEGGYLCGCPPGYYRVGQGHCVSG 2736
Score = 73.2 bits (178), Expect = 1e-12
Identities = 53/168 (31%), Positives = 72/168 (42%), Gaps = 9/168 (5%)
Query: 325 CSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPV 384
C + C S C+C G+ L+ D K C D +EC N C N GS+ C C
Sbjct: 586 CKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKP 645
Query: 385 GFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPL-CFCPEGSVLERDGKTC--SGCSS 441
GFVL P+G+ C + C + C + + SEG C CP G + DG+ C + S
Sbjct: 646 GFVLAPNGRYCTDVDEC-QTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRS 704
Query: 442 PDNGGCSQ-LCV---PLSPVSWECDCF-PGYDLQLDEKSCAASGPQPF 484
GG + +CV P + EC C P Y + C A F
Sbjct: 705 TCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEF 752
Score = 72.0 bits (175), Expect = 3e-12
Identities = 42/114 (36%), Positives = 55/114 (48%), Gaps = 10/114 (8%)
Query: 845 RCISEGEDATCQCLKGFAGDGKL-CSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGY 903
RCI C+C G+ D C D+DEC P + C+NT G Y C+C G+
Sbjct: 509 RCIPTVSSYRCECNMGYKQDANGDCIDVDECTSN----PCTNGDCVNTPGSYYCKCHAGF 564
Query: 904 QGDGIH--CLDIDECQLGEHSCGENASCTNTEGGYTCMC-AG-RLSEPGLICPD 953
Q C+DIDEC C +N C NT+G + C+C AG L+ G C D
Sbjct: 565 QRTPTKQACIDIDECIQNGVLC-KNGRCVNTDGSFQCICNAGFELTTDGKNCVD 617
Score = 72.0 bits (175), Expect = 3e-12
Identities = 40/121 (33%), Positives = 54/121 (44%), Gaps = 4/121 (3%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLG-CKNTPG 376
C L C++ +C S+ C C GY + C D++EC C G C+NTPG
Sbjct: 772 CALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPG 831
Query: 377 SYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPL-CFCPEGSVLERDGKT 435
SY CTCP G+V + + C + C N C + + G C C GS L G
Sbjct: 832 SYSCTCPPGYVFRTETETCEDINECESN--PCVNGACRNNLGSFNCECSPGSKLSSTGLI 889
Query: 436 C 436
C
Sbjct: 890 C 890
Score = 72.0 bits (175), Expect = 3e-12
Identities = 74/277 (26%), Positives = 102/277 (36%), Gaps = 59/277 (21%)
Query: 743 DPCLYQNGGC-EHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVT 801
D C G C C LG C C +M+ + G C+ D++
Sbjct: 1694 DECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCM-------------DMRKSFC 1740
Query: 802 PLDILSKTRVSE--DNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGE---DATCQ 856
T +E N+T+ + + C P C + G C
Sbjct: 1741 YRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEP--------CPTPGTADFKTICG 1792
Query: 857 CLKGFAGD---GKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIH--CL 911
+ GF D GK DIDEC+ +C A+ CIN G + C C G+ + + C
Sbjct: 1793 NIPGFTFDIHTGKAV-DIDECKEIPGIC--ANGVCINQIGSFRCECPTGFSYNDLLLVCE 1849
Query: 912 DIDECQLGEHSCGENASCTNTEGGYTCMC-AGRLSEPGLICPDSTPPPHLREDDHHYSVR 970
DIDEC G++ C NA C N+ G Y C C AG P C D R
Sbjct: 1850 DIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGACVD----------------R 1893
Query: 971 NSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGY 1007
N E P C H G+C+ ++ Y C C G+
Sbjct: 1894 NECLEIP----NVCSH-GLCVDLQG--SYQCICHNGF 1923
Score = 72.0 bits (175), Expect = 3e-12
Identities = 40/119 (33%), Positives = 58/119 (48%), Gaps = 10/119 (8%)
Query: 827 IMVSDQDDCAPVG--CSMYARCISEGEDATCQCLKGF-AGDGKLCSDIDECEMGVPVCPP 883
++ D D+C+ C A CI+ C+C GF C D +EC VC
Sbjct: 1846 LVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVC-- 1903
Query: 884 ASSKCINTEGGYVCRCSEGYQG--DGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMC 940
+ C++ +G Y C C G++ D C+D+DEC+ H CG N +C NT G Y C+C
Sbjct: 1904 SHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECE--RHPCG-NGTCKNTVGSYNCLC 1959
Score = 71.6 bits (174), Expect = 4e-12
Identities = 61/206 (29%), Positives = 86/206 (41%), Gaps = 22/206 (10%)
Query: 756 CKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLDILSKTRVSEDN 815
C G+ CSCREG++ +G C+ LD E ++
Sbjct: 1384 CLNIPGSFKCSCREGWI--GNGIKCIDLD--------ECSNGTHQCSINAQCVNTPGSYR 1433
Query: 816 ITESQHMLVAEIMVSDQDDCAP-VGCSMYARCISEGEDATCQCLKGF--AGDGKLCSDID 872
S+ SD D+CA + +C++ C+C GF A D + C DID
Sbjct: 1434 CACSEGFTGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDID 1493
Query: 873 ECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGD--GIHCLDIDECQLGEHSCGENASCT 930
EC +C C N G + C C +GY+ D G +C DIDEC +C N C
Sbjct: 1494 ECSF-QNIC--VFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDEC-ADPINC-VNGLCV 1548
Query: 931 NTEGGYTCMCAG--RLSEPGLICPDS 954
NT G Y C C +L+ G+ C D+
Sbjct: 1549 NTPGRYECNCPPDFQLNPTGVGCVDN 1574
Score = 71.2 bits (173), Expect = 5e-12
Identities = 63/222 (28%), Positives = 92/222 (41%), Gaps = 27/222 (12%)
Query: 745 CLYQNGGCEH-ICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQV--- 800
CL G C + C G+ C C G+ G C+ D E + N
Sbjct: 2175 CLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTD--------ECSIGNPCGNG 2226
Query: 801 TPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCA--PVGCSMYARCISEGEDATCQCL 858
T +++ + + E M+ E D ++CA P+ C+ RC++ C C
Sbjct: 2227 TCTNVIGSFECNCNEGFEPGPMMNCE----DINECAQNPLLCAF--RCMNTFGSYECTCP 2280
Query: 859 KGFA--GDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGY--QGDGIHCLDID 914
G+A D K+C D+DEC G+ C C N G ++C C G + DG C+D +
Sbjct: 2281 IGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDEN 2340
Query: 915 ECQLGEHSCGENASCTNTEGGYTCMC--AGRLSEPGLICPDS 954
EC+ C EN C N G Y C C + S G C D+
Sbjct: 2341 ECRTKPGIC-ENGRCVNIIGSYRCECNEGFQSSSSGTECLDN 2381
Score = 70.1 bits (170), Expect = 1e-11
Identities = 61/231 (26%), Positives = 90/231 (38%), Gaps = 45/231 (19%)
Query: 743 DPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTC----------LALDGHQLLAGG 792
D C N +C G+ C C+ GF+ A +G+ C + ++GH + + G
Sbjct: 619 DECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQTPGICMNGHCINSEG 678
Query: 793 E------------------VDLKNQVTPLDILSK---TRVSEDNITESQHMLVAEIMVSD 831
VD + T + K R +T+S+ A
Sbjct: 679 SFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSE-CCCANPDYGF 737
Query: 832 QDDCAPVGCSMYARCISEGEDATCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINT 891
+ C P A C G DG+ DI+EC + +C A+ C N
Sbjct: 738 GEPCQPCPAKNSAEF-----HGLCSSGVGITVDGR---DINECALDPDIC--ANGICENL 787
Query: 892 EGGYVCRCSEGYQGD--GIHCLDIDECQLGEHSCGENASCTNTEGGYTCMC 940
G Y C C+ GY+ D G +C+DIDEC + C +N C NT G Y+C C
Sbjct: 788 RGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLC-DNGLCRNTPGSYSCTC 837
Score = 68.2 bits (165), Expect = 5e-11
Identities = 52/165 (31%), Positives = 72/165 (43%), Gaps = 27/165 (16%)
Query: 855 CQCLKGFAGD--GKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGY--QGDGIHC 910
C C G+ D G+ C DIDEC + +C + C NT G Y C C GY + + C
Sbjct: 793 CNCNSGYEPDASGRNCIDIDECLVNRLLCD--NGLCRNTPGSYSCTCPPGYVFRTETETC 850
Query: 911 LDIDECQLGEHSCGENASCTNTEGGYTCMCA--GRLSEPGLICPDSTPPPHLREDDHHYS 968
DI+EC+ + C N +C N G + C C+ +LS GLIC DS
Sbjct: 851 EDINECE--SNPC-VNGACRNNLGSFNCECSPGSKLSSTGLICIDSLKGT--------CW 899
Query: 969 VRNSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQ 1013
+ DS C ++ +G L C + A C ERC+
Sbjct: 900 LNIQDSRCEVNINGATLKSECCATLGAAWGSPC--------ERCE 936
Score = 67.0 bits (162), Expect = 1e-10
Identities = 45/139 (32%), Positives = 57/139 (41%), Gaps = 8/139 (5%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLG-CKNTPG 376
C G+CS C S C+C GY + + C D+NEC + C G C NTPG
Sbjct: 2020 CVALPGSCSPGTCQNLEGSFRCICPPGYEVKSEN--CIDINECDEDPNICLFGSCTNTPG 2077
Query: 377 SYYCTCPVGFVLLPDGKRCHQLVS--CPRNV--SECSHDCVLTSEGPLCFCPEGSVLERD 432
+ C CP GFVL +G+RC C N +CS + C C + E
Sbjct: 2078 GFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSK-MPGEGW 2136
Query: 433 GKTCSGCSSPDNGGCSQLC 451
G C C D LC
Sbjct: 2137 GDPCELCPKDDEVAFQDLC 2155
Score = 66.6 bits (161), Expect = 1e-10
Identities = 45/161 (27%), Positives = 68/161 (42%), Gaps = 8/161 (4%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLG-CKNTPG 376
C+ G C C S C C +GY LS D + CED++EC C G C NT G
Sbjct: 1654 CQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLG 1713
Query: 377 SYYCTCPVGFVLLPDGKRCHQLVS--CPR--NVSECSHDCVLTSEGPLCFCPEGSVLERD 432
+Y C CP ++ + G C + C R N + C ++ +C C +V +
Sbjct: 1714 NYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTY-NVGKAW 1772
Query: 433 GKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDE 473
K C C +P +C + ++ D G + +DE
Sbjct: 1773 NKPCEPCPTPGTADFKTICGNIPGFTF--DIHTGKAVDIDE 1811
Score = 66.6 bits (161), Expect = 1e-10
Identities = 64/271 (23%), Positives = 89/271 (32%), Gaps = 82/271 (30%)
Query: 292 LGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDR 351
+G + P + D ++ C+ + G C + C + S+ C C EG+ S
Sbjct: 2316 IGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSG 2375
Query: 352 KYCED--------------------------VNECAF-----WNHGCTL----------- 369
C D +EC W H C L
Sbjct: 2376 TECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKK 2435
Query: 370 ----------------GCK------------NTPGSYYCTCPVGFVLLPDGKRCHQLVSC 401
CK NT GS+ C C VG+ G C L C
Sbjct: 2436 ICPHGPGYTTDGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDEC 2495
Query: 402 PRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSG---CSSPDNGGCSQLCVPLSPVS 458
++ C++ C T C CP G VL+ DGKTC C + + C LCV +
Sbjct: 2496 SQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQH-NCQFLCVN-TLGG 2553
Query: 459 WECDCFPGYDLQ----LDEKSCAASGPQPFL 485
+ C C PG+ +D C G QP L
Sbjct: 2554 FTCKCPPGFTQHHTACIDNNEC---GSQPSL 2581
Score = 66.2 bits (160), Expect = 2e-10
Identities = 31/79 (39%), Positives = 40/79 (50%), Gaps = 1/79 (1%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLG-CKNTPG 376
C+ G C C + S C C G+ S + CED++EC+ C G C NT G
Sbjct: 280 CQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVG 339
Query: 377 SYYCTCPVGFVLLPDGKRC 395
SY+C CP G+V DG RC
Sbjct: 340 SYFCVCPRGYVTSTDGSRC 358
Score = 66.2 bits (160), Expect = 2e-10
Identities = 70/281 (24%), Positives = 108/281 (38%), Gaps = 37/281 (13%)
Query: 742 ADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVT 801
++PC NG C + G+ +C C GF + + C+ +D + + G + +
Sbjct: 541 SNPCT--NGDCVNTP----GSYYCKCHAGFQRTPTKQACIDID--ECIQNGVLCKNGRCV 592
Query: 802 PLD--ILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQCLK 859
D + T+ ++ + D D+C + CI+E C C
Sbjct: 593 NTDGSFQCICNAGFELTTDGKNCV-------DHDECTTTNMCLNGMCINEDGSFKCICKP 645
Query: 860 GF--AGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQ--GDGIHCLDIDE 915
GF A +G+ C+D+DEC+ +C + CIN+EG + C C G DG C+D
Sbjct: 646 GFVLAPNGRYCTDVDECQT-PGIC--MNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHM 702
Query: 916 CQLGEHSCGENASCTNTEGGYT---CMCAG---RLSEPGLICP--DSTPPPHLREDDHHY 967
+ G T C CA EP CP +S L
Sbjct: 703 RSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGI 762
Query: 968 SVRNSD-SECPLSHDGYCLHDGVCMYIEALDKYACNCVVGY 1007
+V D +EC L D +G+C + Y CNC GY
Sbjct: 763 TVDGRDINECALDPD--ICANGICENLRG--SYRCNCNSGY 799
Score = 65.5 bits (158), Expect = 3e-10
Identities = 48/164 (29%), Positives = 61/164 (37%), Gaps = 7/164 (4%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGS 377
C G CS+ C S C C GY L C D +EC+ N C N GS
Sbjct: 2175 CLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGS 2234
Query: 378 YYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCS 437
+ C C GF P C + C +N C+ C+ T C CP G L D K C
Sbjct: 2235 FECNCNEGFEPGP-MMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCK 2293
Query: 438 GCSSPDNG-----GCSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
G +C L ++ C C PG + D + C
Sbjct: 2294 DLDECAEGLHDCESRGMMCKNLIG-TFMCICPPGMARRPDGEGC 2336
Score = 64.3 bits (155), Expect = 7e-10
Identities = 44/156 (28%), Positives = 64/156 (41%), Gaps = 7/156 (4%)
Query: 325 CSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLG-CKNTPGSYYCTCP 383
C + C ++ C C G+ + D + C+D++EC+F N C G C N PG ++C C
Sbjct: 1460 CENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNI-CVFGTCNNLPGMFHCICD 1518
Query: 384 VGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPD 443
G+ L G C + C ++ + CV T C CP L G GC
Sbjct: 1519 DGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTG---VGCVDNR 1575
Query: 444 NGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAAS 479
G C P S C+ G + + SC S
Sbjct: 1576 VGNCYLKFGPRGDGSLSCNTEIG--VGVSRSSCCCS 1609
Score = 63.9 bits (154), Expect = 9e-10
Identities = 40/142 (28%), Positives = 60/142 (42%), Gaps = 5/142 (3%)
Query: 340 MCAEGYALSRDRKYCEDVNECAFWNHGCTLG-CKNTPGSYYCTCPVGFVLLPDGKRCHQL 398
+C+ G ++ D + D+NECA C G C+N GSY C C G+ G+ C +
Sbjct: 755 LCSSGVGITVDGR---DINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDI 811
Query: 399 VSCPRNVSECSHDCVLTSEGPL-CFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPV 457
C N C + + G C CP G V + +TC + ++ C +
Sbjct: 812 DECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPCVNGACRNNLG 871
Query: 458 SWECDCFPGYDLQLDEKSCAAS 479
S+ C+C PG L C S
Sbjct: 872 SFNCECSPGSKLSSTGLICIDS 893
Score = 63.9 bits (154), Expect = 9e-10
Identities = 26/68 (38%), Positives = 34/68 (50%)
Query: 325 CSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPV 384
C S C L S+ C C G++ + C DVNEC+ + C GC NT G Y C CP
Sbjct: 2664 CGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGYLCGCPP 2723
Query: 385 GFVLLPDG 392
G+ + G
Sbjct: 2724 GYYRVGQG 2731
Score = 63.2 bits (152), Expect = 1e-09
Identities = 33/88 (37%), Positives = 45/88 (51%), Gaps = 7/88 (7%)
Query: 857 CLKGFAGDGKL--CSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGI--HCLD 912
C +GF + + C D+DEC+ +C CINT G + CRC G++ C D
Sbjct: 261 CRRGFIPNIRTGACQDVDECQAIPGICQ--GGNCINTVGSFECRCPAGHKQSETTQKCED 318
Query: 913 IDECQLGEHSCGENASCTNTEGGYTCMC 940
IDEC + C E C+NT G Y C+C
Sbjct: 319 IDECSIIPGIC-ETGECSNTVGSYFCVC 345
Score = 62.0 bits (149), Expect = 3e-09
Identities = 47/154 (30%), Positives = 64/154 (41%), Gaps = 30/154 (19%)
Query: 833 DDCAPVGCSMYARCISEGEDATCQCLKGFAGDGK--LCSDIDECEMGVPVCPPASSKCIN 890
+ C PV + Y GE GF + + DIDEC+ +C CIN
Sbjct: 1619 ETCPPVNSTEYYTLCPGGE--------GFRPNPITIILEDIDECQELPGLCQ--GGNCIN 1668
Query: 891 TEGGYVCRCSEGY--QGDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMCAGRLSEPG 948
T G + C C +GY D C DIDEC CG +C NT G YTC+C
Sbjct: 1669 TFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGP-GTCYNTLGNYTCIC-------- 1719
Query: 949 LICPDSTPPPHLREDDHHYSVRNSDSECPLSHDG 982
PP +++ + H + S C S++G
Sbjct: 1720 -------PPEYMQVNGGHNCMDMRKSFCYRSYNG 1746
Score = 60.1 bits (144), Expect = 1e-08
Identities = 48/174 (27%), Positives = 68/174 (39%), Gaps = 20/174 (11%)
Query: 341 CAEGYALSRDRKYCEDVNECAFWNHGCTLG-CKNTPGSYYCTCPVGFVLLPDGKRCHQLV 399
C G+ + C+DV+EC C G C NT GS+ C CP G ++C +
Sbjct: 261 CRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDID 320
Query: 400 SCPRNVSEC-SHDCVLTSEGPLCFCPEGSVLERDGKTCSG------CSSPDNGGCSQLCV 452
C C + +C T C CP G V DG C S NG C+Q +
Sbjct: 321 ECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQE-L 379
Query: 453 PLSPVSWECDCFPG--YDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDYG 504
P +C C PG + + ++C G S++ R + DG G
Sbjct: 380 PGRMTKMQCCCEPGRCWGIGTIPEACPVRG---------SEEYRRLCMDGLPMG 424
Score = 58.2 bits (139), Expect = 5e-08
Identities = 51/183 (27%), Positives = 79/183 (43%), Gaps = 41/183 (22%)
Query: 742 ADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCL-ALDGHQLLAGGEVDLKNQV 800
++PC+ NG C + LG+ C C G +S G C+ +L G L
Sbjct: 858 SNPCV--NGAC----RNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWL----------- 900
Query: 801 TPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQCLKG 860
NI +S+ + + CA +G + + C E + C +G
Sbjct: 901 --------------NIQDSRCEVNINGATLKSECCATLGAAWGSPC--ERCELDTACPRG 944
Query: 861 FAG-DGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEG--YQGDGIHCLDI--DE 915
A G C D++ECE+ VCP + +C+N++G + C C EG G G CLDI ++
Sbjct: 945 LARIKGVTCEDVNECEVFPGVCP--NGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQ 1002
Query: 916 CQL 918
C L
Sbjct: 1003 CYL 1005
Score = 55.5 bits (132), Expect = 3e-07
Identities = 50/179 (27%), Positives = 73/179 (40%), Gaps = 28/179 (15%)
Query: 741 GADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALD----GHQLLAGGEVDL 796
G+ P L G + IC+ G+ C C+ GF + G C +D H+ G +
Sbjct: 2576 GSQPSLC---GAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQ--- 2629
Query: 797 KNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQ 856
+IL R QH + + D+++C+ A C + C
Sbjct: 2630 -------NILGGYRCGCPQ-GYIQHYQWNQCV--DENECSNPNACGSASCYNTLGSYKCA 2679
Query: 857 CLKGFAGD--GKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQ--GDGIHCL 911
C GF+ D C D++EC C + C NTEGGY+C C GY G G HC+
Sbjct: 2680 CPSGFSFDQFSSACHDVNECSSSKNPC---NYGCSNTEGGYLCGCPPGYYRVGQG-HCV 2734
Score = 53.1 bits (126), Expect = 2e-06
Identities = 52/198 (26%), Positives = 79/198 (39%), Gaps = 25/198 (12%)
Query: 756 CKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLDILSKTRVS-ED 814
C G+ C+C EGF DG TC +D ++L L++ R E
Sbjct: 1425 CVNTPGSYRCACSEGF--TGDGFTCSDVDE----CAENINLCENGQCLNVPGAYRCECEM 1478
Query: 815 NITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQCLKGFAGD--GKLCSDID 872
T + + D D+C+ ++ C + C C G+ D G C+DID
Sbjct: 1479 GFTPASDSRSCQ----DIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDID 1534
Query: 873 ECEMGVPVCPPASSKCINTEGGYVCRCSEGYQ--GDGIHCLD--IDECQLGEHSCGENAS 928
EC + + C+NT G Y C C +Q G+ C+D + C L G+ +
Sbjct: 1535 ECADPINC---VNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSL 1591
Query: 929 CTNTEGGY-----TCMCA 941
NTE G +C C+
Sbjct: 1592 SCNTEIGVGVSRSSCCCS 1609
Score = 51.6 bits (122), Expect = 4e-06
Identities = 27/71 (38%), Positives = 36/71 (50%), Gaps = 6/71 (8%)
Query: 871 IDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGI-HCLDIDECQLGEHSCGENASC 929
ID C+ +C + +CI T Y C C+ GY+ D C+D+DEC + C N C
Sbjct: 495 IDICKHHANLC--LNGRCIPTVSSYRCECNMGYKQDANGDCIDVDECT--SNPC-TNGDC 549
Query: 930 TNTEGGYTCMC 940
NT G Y C C
Sbjct: 550 VNTPGSYYCKC 560
Score = 50.8 bits (120), Expect = 8e-06
Identities = 38/130 (29%), Positives = 49/130 (37%), Gaps = 8/130 (6%)
Query: 354 CEDVNECAFWNHGCTLG-CKNTPGSYYCTCPVGFVLLPDGKRC--HQLVSC--PRNVSEC 408
CEDVNEC + C G C N+ GS++C CP G L G+ C ++ C + EC
Sbjct: 953 CEDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDEC 1012
Query: 409 SHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYD 468
H C C G+ G C C P LC + + D G
Sbjct: 1013 IHPVPGKFRMDACCCAVGAAW---GTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRP 1069
Query: 469 LQLDEKSCAA 478
D C A
Sbjct: 1070 FYKDINECKA 1079
Score = 49.7 bits (117), Expect = 2e-05
Identities = 29/87 (33%), Positives = 40/87 (45%), Gaps = 7/87 (8%)
Query: 831 DQDDCAPV-GCSMYARCISEGEDATCQCLKGF--AGDGKLCSDIDECEMGVPVCPPASSK 887
D D+C + G CI+ C+C G + + C DIDEC + +C + +
Sbjct: 276 DVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICE--TGE 333
Query: 888 CINTEGGYVCRCSEGY--QGDGIHCLD 912
C NT G Y C C GY DG C+D
Sbjct: 334 CSNTVGSYFCVCPRGYVTSTDGSRCID 360
Score = 44.3 bits (103), Expect = 7e-04
Identities = 51/237 (21%), Positives = 85/237 (35%), Gaps = 40/237 (16%)
Query: 743 DPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTP 802
DP + NG CE++ G+ C+C G+ + G+ C+ +D E + +
Sbjct: 775 DPDICANGICENL----RGSYRCNCNSGYEPDASGRNCIDID--------ECLVNRLLCD 822
Query: 803 LDILSKTRVSEDNITESQHMLVAEIMV-SDQDDCAPVGCSMYARCISEGEDATCQCLKG- 860
+ T S ++ E D ++C C + C + C+C G
Sbjct: 823 NGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPC-VNGACRNNLGSFNCECSPGS 881
Query: 861 -FAGDGKLCSDI-----------DECEMGVPVCPPASSKC--INTEGGYVCR-------C 899
+ G +C D CE+ + S C + G C C
Sbjct: 882 KLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPCERCELDTAC 941
Query: 900 SEGYQG-DGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMCAG--RLSEPGLICPD 953
G G+ C D++EC++ C N C N++G + C C L G +C D
Sbjct: 942 PRGLARIKGVTCEDVNECEVFPGVC-PNGRCVNSKGSFHCECPEGLTLDGTGRVCLD 997
Score = 43.9 bits (102), Expect = 0.001
Identities = 48/193 (24%), Positives = 71/193 (36%), Gaps = 46/193 (23%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDV--NECAF-WNHGCTLGCKNT 374
C++ G C + C S C C EG L + C D+ +C W+ +
Sbjct: 959 CEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECI--HPV 1016
Query: 375 PGSY---YCTCPVGFVLLPDGKRC------HQLVSCPR------------------NVSE 407
PG + C C VG + + C CPR +++E
Sbjct: 1017 PGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINE 1076
Query: 408 CS--------HDCVLTSEGPLCFCPEGSVLERDGKTCSGCS----SPDNGGCSQLCVPLS 455
C C T C C G L+ + + C+ SPD G S +CV +
Sbjct: 1077 CKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCG-SGICVN-T 1134
Query: 456 PVSWECDCFPGYD 468
P S+EC+CF GY+
Sbjct: 1135 PGSFECECFEGYE 1147
Score = 40.4 bits (93), Expect = 0.010
Identities = 33/135 (24%), Positives = 48/135 (35%), Gaps = 23/135 (17%)
Query: 325 CSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFW----NHGCTLGCKNTPGSYYC 380
C + C +L S C C+ G LS C D + W + C + C
Sbjct: 861 CVNGACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSEC 920
Query: 381 TCPVGFVLLPDGKRCHQLVSCPR-----------NVSEC--------SHDCVLTSEGPLC 421
+G +RC +CPR +V+EC + CV + C
Sbjct: 921 CATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECEVFPGVCPNGRCVNSKGSFHC 980
Query: 422 FCPEGSVLERDGKTC 436
CPEG L+ G+ C
Sbjct: 981 ECPEGLTLDGTGRVC 995
Score = 37.0 bits (84), Expect = 0.11
Identities = 42/200 (21%), Positives = 66/200 (33%), Gaps = 61/200 (30%)
Query: 323 GNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNE----------------------- 359
G C + C S C C G A+ D + C D +
Sbjct: 666 GICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTK 725
Query: 360 ----CAFWNHGCTLGCKNTP----GSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHD 411
CA ++G C+ P ++ C G + DG R+++EC+ D
Sbjct: 726 SECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDG----------RDINECALD 775
Query: 412 CVLTSEGPL--------CFCPEGSVLERDGKTCSGCSS-------PDNGGCSQLCVPLSP 456
+ + G C C G + G+ C DNG C +P
Sbjct: 776 PDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRN-----TP 830
Query: 457 VSWECDCFPGYDLQLDEKSC 476
S+ C C PGY + + ++C
Sbjct: 831 GSYSCTCPPGYVFRTETETC 850
Score = 33.9 bits (76), Expect = 0.96
Identities = 13/39 (33%), Positives = 18/39 (46%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCED 356
C + G C + C + S+ C+C GY S D C D
Sbjct: 322 CSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCID 360
>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
Length = 1541
Score = 121 bits (304), Expect = 4e-27
Identities = 64/164 (39%), Positives = 80/164 (48%), Gaps = 6/164 (3%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGS 377
C R G+C C C C GY L+ D K CEDV+ECA C GC NT GS
Sbjct: 248 CANRNGSCMHR-CQVVRGLARCECHVGYQLAADGKACEDVDECAAGLAQCAHGCLNTQGS 306
Query: 378 YYCTCPVGFVLLPDGKRCHQLV-----SCPRNVSECSHDCVLTSEGPLCFCPEGSVLERD 432
+ C C G+ L DG++C+++ SC N CSH C TS GPLC CP G L+ D
Sbjct: 307 FKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLCTCPRGYELDTD 366
Query: 433 GKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
+TC + C Q +P +EC C+ GY L D C
Sbjct: 367 QRTCIDVDDCADSPCCQQVCTNNPGGYECGCYAGYRLSADGCGC 410
Score = 101 bits (251), Expect = 5e-21
Identities = 84/301 (27%), Positives = 112/301 (37%), Gaps = 59/301 (19%)
Query: 736 PLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVD 795
P + D C NGGC+H C G+ C C+ GF +D +TCLA++ L GG
Sbjct: 156 PRCQYDVDECRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQH 215
Query: 796 LKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATC 855
Q+T + R + +H + + CA S RC A C
Sbjct: 216 HCVQLTITRHRCQCRPGFQLQEDGRHCV-------RRSPCANRNGSCMHRCQVVRGLARC 268
Query: 856 QCLKGF--AGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQ--GDGIHCL 911
+C G+ A DGK C D+DEC G+ C + C+NT+G + C C GY+ DG C
Sbjct: 269 ECHVGYQLAADGKACEDVDECAAGLAQC---AHGCLNTQGSFKCVCHAGYELGADGRQCY 325
Query: 912 DID-----ECQLGEHSCGENAS-------------------------------------- 928
I+ C+ C S
Sbjct: 326 RIEMEIVNSCEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCIDVDDCADSPCCQQV 385
Query: 929 CTNTEGGYTCMC-AG-RLSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCLH 986
CTN GGY C C AG RLS G C D R H+ + S GY LH
Sbjct: 386 CTNNPGGYECGCYAGYRLSADGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLH 445
Query: 987 D 987
+
Sbjct: 446 E 446
Score = 92.8 bits (229), Expect = 2e-18
Identities = 61/175 (34%), Positives = 85/175 (48%), Gaps = 18/175 (10%)
Query: 312 EPEQKLCKLRKGNCSSTVC---GQDL--QSHLCMCAEGYALSRDRKYCE-DVNECAFWNH 365
+P+++ C CS+++C G+ + + C C G+ R C+ DV+EC N
Sbjct: 117 QPDEEGCL--SAECSASLCFHGGRCVPGSAQPCHCPPGFQGPR----CQYDVDECRTHNG 170
Query: 366 GCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCV-LTSEGPLCFCP 424
GC C NTPGSY C C GF L D + C + SC C H CV LT C C
Sbjct: 171 GCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCR 230
Query: 425 EGSVLERDGKTC---SGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
G L+ DG+ C S C++ NG C C + ++ C+C GY L D K+C
Sbjct: 231 PGFQLQEDGRHCVRRSPCAN-RNGSCMHRCQVVRGLA-RCECHVGYQLAADGKAC 283
Score = 80.5 bits (197), Expect = 9e-15
Identities = 42/125 (33%), Positives = 53/125 (42%), Gaps = 2/125 (1%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGS 377
C+ G CS C LC C GY L D++ C DV++CA + C C N PG
Sbjct: 335 CEANNGGCSHG-CSHTSAGPLCTCPRGYELDTDQRTCIDVDDCAD-SPCCQQVCTNNPGG 392
Query: 378 YYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCS 437
Y C C G+ L DG C + C + C H C + C C G L D + CS
Sbjct: 393 YECGCYAGYRLSADGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCS 452
Query: 438 GCSSP 442
P
Sbjct: 453 PLEEP 457
Score = 75.1 bits (183), Expect = 4e-13
Identities = 50/145 (34%), Positives = 62/145 (42%), Gaps = 11/145 (7%)
Query: 341 CAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYY-CTCPVGFVLLPDGKRC-HQL 398
C G+ D + C EC+ C G + PGS C CP GF G RC + +
Sbjct: 110 CCRGWMQQPDEEGCLSA-ECSA--SLCFHGGRCVPGSAQPCHCPPGF----QGPRCQYDV 162
Query: 399 VSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSP--DNGGCSQLCVPLSP 456
C + C H CV T LC C G L D +TC +S NGGC CV L+
Sbjct: 163 DECRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTI 222
Query: 457 VSWECDCFPGYDLQLDEKSCAASGP 481
C C PG+ LQ D + C P
Sbjct: 223 TRHRCQCRPGFQLQEDGRHCVRRSP 247
Score = 61.6 bits (148), Expect = 4e-09
Identities = 75/309 (24%), Positives = 106/309 (34%), Gaps = 77/309 (24%)
Query: 743 DPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTP 802
D C GGCEH C G+ CSC G+ D + C L+ + GE+ +
Sbjct: 414 DECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDGELPFVRPLPH 473
Query: 803 LDILSKT-----------RVSEDNITESQHMLVAEIMVSDQD---DCAPV--GCSMYARC 846
+ +L E+ +H L + + D DC+ C C
Sbjct: 474 IAVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTC 533
Query: 847 ISEGEDATCQCLKGFAGDGKLCSDIDECEMGVPVCPP------ASSKCINTEGGY----- 895
+ G D C C +G+ G +C++ CPP S C GG
Sbjct: 534 LL-GLDG-CDCPEGWT--GLICNE---------TCPPDTFGKNCSFSCSCQNGGTCDSVT 580
Query: 896 -VCRCSEGYQGDGIHCLDIDECQLGEHS--CGENASCTNTEGGYTCMCAGRLSEPGL--- 949
CRC G G D C G + C + +C N G + L +PGL
Sbjct: 581 GACRCPPGVSGTNCE----DGCPKGYYGKHCRKKCNCAN-RGRCHRLYGACLCDPGLYGR 635
Query: 950 ICPDSTPP----PHLREDDHHYSVRNSDSECPLSHDGYC-LHDGVCMYIEALDKYACNCV 1004
C + PP P E + +C H C DG +C+C
Sbjct: 636 FCHLTCPPWAFGPGCSE----------ECQCVQPHTQSCDKRDG-----------SCSCK 674
Query: 1005 VGYIGERCQ 1013
G+ GERCQ
Sbjct: 675 AGFRGERCQ 683
Score = 54.7 bits (130), Expect = 5e-07
Identities = 47/163 (28%), Positives = 60/163 (36%), Gaps = 31/163 (19%)
Query: 324 NCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPG------S 377
NCS+ D S LC+C GY R CE + GC C+ G S
Sbjct: 874 NCSAGHGSCDAISGLCLCEAGYVGPR----CEQQCPQGHFGPGCEQRCQCQHGAACDHVS 929
Query: 378 YYCTCPVGFVLLPDGKRCHQLVSCP--------RNVSECSHDCVLTSEGPLCFCPEGSVL 429
CTCP G+ G C +CP R+ C+ + C CP G
Sbjct: 930 GACTCPAGW----RGTFCEH--ACPAGFFGLDCRSACNCTAGAACDAVNGSCLCPAGRRG 983
Query: 430 ERDGKTCSGCSSPDNGGCSQLC-----VPLSPVSWECDCFPGY 467
R +TC + N CSQ C PV +C C PG+
Sbjct: 984 PRCAETCPAHTYGHN--CSQACACFNGASCDPVHGQCHCAPGW 1024
Score = 51.6 bits (122), Expect = 4e-06
Identities = 52/194 (26%), Positives = 73/194 (37%), Gaps = 47/194 (24%)
Query: 839 GCSMYARCIS------EGEDATCQCLKGFAGDGKLCSDIDECEMGV--PVC-----PPAS 885
GCS +C+ + D +C C GF G+ C ECE+G P C P
Sbjct: 649 GCSEECQCVQPHTQSCDKRDGSCSCKAGFRGER--CQA--ECELGYFGPGCWQACTCPVG 704
Query: 886 SKCINTEGGYVCRCSEGYQGDGIHCLDIDECQLGEH--SCGENASCTNTEGGYTCMCAGR 943
C + G RC G+QG+ EC +G +C + SC GG C
Sbjct: 705 VACDSVSGECGKRCPAGFQGEDCG----QECPVGTFGVNCSSSCSC----GGAPCH---- 752
Query: 944 LSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCLHD--GVCMYIEALDKY-- 999
G+ PP ED +++CP G + C + D
Sbjct: 753 ----GVTGQCRCPPGRTGED--------CEADCPEGRWGLGCQEICPACQHAARCDPETG 800
Query: 1000 ACNCVVGYIGERCQ 1013
AC C+ G++G RCQ
Sbjct: 801 ACLCLPGFVGSRCQ 814
Score = 43.9 bits (102), Expect = 0.001
Identities = 51/211 (24%), Positives = 69/211 (32%), Gaps = 68/211 (32%)
Query: 832 QDDCAP----VGCSMYARCISEG----EDATCQCLKGFAGD-----------GKLCSDID 872
+ +C P GC C++ G C C G+ GD G+ C+
Sbjct: 1073 EKECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQ-- 1130
Query: 873 ECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIH-----------CLDIDECQLGEH 921
C CPP ++ C + G CRC G+ G G C + +C
Sbjct: 1131 RCS-----CPPGAA-CHHVTGA--CRCPPGFTGSGCEQACPPGSFGEDCAQMCQCP---- 1178
Query: 922 SCGENASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLSHD 981
GEN +C G TC CA P C PP + C
Sbjct: 1179 --GENPACHPATG--TCSCAAGYHGPS--CQQRCPPGRYGP--------GCEQLCG---- 1220
Query: 982 GYCLHDGVCMYIEALDKYACNCVVGYIGERC 1012
CL+ G C AC C G++G C
Sbjct: 1221 --CLNGGSCDAATG----ACRCPTGFLGTDC 1245
Score = 43.1 bits (100), Expect = 0.002
Identities = 50/205 (24%), Positives = 67/205 (32%), Gaps = 54/205 (26%)
Query: 834 DCAPVGCSMYARCISEGEDATCQCLKGFAGD-----------GKLCSDIDECEMGVPVCP 882
DC C+ A + + +C C G G G CS C G C
Sbjct: 955 DCRSA-CNCTAGAACDAVNGSCLCPAGRRGPRCAETCPAHTYGHNCSQACACFNGAS-CD 1012
Query: 883 PASSKCINTEGGYVCRCSEGYQGDGIHCLDIDECQLGEHSCGENASCTNTEGGYTC---- 938
P +C C+ G+ G CL L +C + C N G TC
Sbjct: 1013 PVHGQC---------HCAPGWMGPS--CLQACPAGLYGDNCRHSCLCQN---GGTCDPVS 1058
Query: 939 -MCAGRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCLHDGVCMYIEALD 997
CA GL C P +R H G CL+ G+C D
Sbjct: 1059 GHCACPEGWAGLACEKECLPRDVRAG--------------CRHSGGCLNGGLC------D 1098
Query: 998 KYA--CNCVVGYIGERCQYRDLKWW 1020
+ C C G+ G++CQ L+ W
Sbjct: 1099 PHTGRCLCPAGWTGDKCQSPCLRGW 1123
Score = 41.6 bits (96), Expect = 0.005
Identities = 48/191 (25%), Positives = 62/191 (32%), Gaps = 51/191 (26%)
Query: 840 CSMYARCISEGEDATCQCLKGFAGD-----------GKLCSDIDECEMGVPVCPPASSKC 888
CS + E TC+C GF G G C + C+ G P C P S +C
Sbjct: 1348 CSCHNNSTCEPATGTCRCGPGFYGQACEHPCPPGFHGAGCQGLCWCQHGAP-CDPISGRC 1406
Query: 889 INTEG--GYVCR--CSEGYQGDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMCAGRL 944
+ G G+ C C G G+G H C C A C G C+C
Sbjct: 1407 LCPAGFHGHFCERGCEPGSFGEGCH----QRC-----DCDGGAPCDPVTG--LCLC---- 1451
Query: 945 SEPGLICPDSTPPPHLREDDHHYSVRNSD--SECPLSHDGYCLHDGVCMYIEALDKYACN 1002
PP + R C L D C C + C+
Sbjct: 1452 ------------PPGRSGATCNLDCRRGQFGPSCTLHCD--CGGGADCDPVSG----QCH 1493
Query: 1003 CVVGYIGERCQ 1013
CV GY+G C+
Sbjct: 1494 CVDGYMGPTCR 1504
Score = 40.4 bits (93), Expect = 0.010
Identities = 41/171 (23%), Positives = 50/171 (29%), Gaps = 40/171 (23%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYC--EDVNECAFWNHGCTLGCKNTP 375
C + G V G C C EG+A K C DV + GC G P
Sbjct: 1046 CLCQNGGTCDPVSGH------CACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGGLCDP 1099
Query: 376 GSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKT 435
+ C CP G+ G +C S C + C CP G+
Sbjct: 1100 HTGRCLCPAGWT----GDKCQ---------SPCLRGWFGEACAQRCSCPPGAACHHVTGA 1146
Query: 436 CSGCSSPDNGGCSQLCVPLS-------------------PVSWECDCFPGY 467
C GC Q C P S P + C C GY
Sbjct: 1147 CRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGY 1197
Score = 40.4 bits (93), Expect = 0.010
Identities = 48/207 (23%), Positives = 67/207 (32%), Gaps = 53/207 (25%)
Query: 830 SDQDDCAP----VGCSMYARCISEGE----DATCQCLKGFAGD-----------GKLCSD 870
S Q C P GC C++ G C+C GF G G C+
Sbjct: 1201 SCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTH 1260
Query: 871 IDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGD--GIHCLDIDECQLGEHSCG-ENA 927
+ C G C P + C+ G RC G + G+ C EH+C N
Sbjct: 1261 VCGCGQGA-ACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGC---------EHTCSCRNG 1310
Query: 928 SCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCLHD 987
+ G +C C L G C + PP H EC C ++
Sbjct: 1311 GLCHASNG-SCSCG--LGWTGRHCELACPPGRYGAACH--------LECS------CHNN 1353
Query: 988 GVCMYIEALDKYACNCVVGYIGERCQY 1014
C C C G+ G+ C++
Sbjct: 1354 STCEPATG----TCRCGPGFYGQACEH 1376
Score = 40.0 bits (92), Expect = 0.013
Identities = 47/170 (27%), Positives = 59/170 (34%), Gaps = 40/170 (23%)
Query: 850 GEDATCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIH 909
GED C +G G G C+ P C A+ +C G C C G+ G
Sbjct: 766 GEDCEADCPEGRWGLG--------CQEICPACQHAA-RCDPETGA--CLCLPGFVGS--R 812
Query: 910 CLDIDECQLGEH--SCGENASCTNTEGGYT----CMCAGRLSEPGLICPDSTPPPHLRED 963
C D+ C G + SC SC N + C CA + G C + H D
Sbjct: 813 CQDV--CPAGWYGPSCQTRCSCANDGHCHPATGHCSCAPGWT--GFSCQRACDTGHWGPD 868
Query: 964 DHHYSVRNSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQ 1013
H C H G C I L C C GY+G RC+
Sbjct: 869 CSH------PCNCSAGH-------GSCDAISGL----CLCEAGYVGPRCE 901
Score = 38.9 bits (89), Expect = 0.030
Identities = 45/177 (25%), Positives = 64/177 (36%), Gaps = 36/177 (20%)
Query: 324 NCSSTV-CGQ----DLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLG----CKNT 374
NC+ CGQ D + C+C G A R + C H C+ C +
Sbjct: 1257 NCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGLCHAS 1316
Query: 375 PGSYYCTCPVGFVLLPDGKRCHQLVSCP--RNVSECSHDCVLTSEGPL------CFCPEG 426
GS C+C +G+ G+ C ++CP R + C +C + C C G
Sbjct: 1317 NGS--CSCGLGWT----GRHCE--LACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPG 1368
Query: 427 SVLERDGKTCSGCSSPD--NGGCSQLC-----VPLSPVSWECDCFPGYDLQLDEKSC 476
G+ C P GC LC P P+S C C G+ E+ C
Sbjct: 1369 FY----GQACEHPCPPGFHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERGC 1421
Score = 38.1 bits (87), Expect = 0.051
Identities = 39/148 (26%), Positives = 49/148 (33%), Gaps = 39/148 (26%)
Query: 834 DCAPVG-----CSMYARCISEGE----DATCQCLKGFAGD-----------GKLCSDIDE 873
D P G C C ++G C C G+ G G CS
Sbjct: 815 DVCPAGWYGPSCQTRCSCANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCN 874
Query: 874 CEMGVPVCPPASSKCINTEGGYV---C--RCSEGYQGDGIHCLDIDECQLGEHSCGENAS 928
C G C S C+ E GYV C +C +G+ G G CQ C A+
Sbjct: 875 CSAGHGSCDAISGLCL-CEAGYVGPRCEQQCPQGHFGPGCE----QRCQ-----CQHGAA 924
Query: 929 CTNTEGGYTCMCAGRLSEPGLICPDSTP 956
C + G TC R G C + P
Sbjct: 925 CDHVSGACTCPAGWR----GTFCEHACP 948
Score = 38.1 bits (87), Expect = 0.051
Identities = 47/167 (28%), Positives = 56/167 (33%), Gaps = 41/167 (24%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCM--CAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTP 375
C+ G C CG C C G+ + + C W C G P
Sbjct: 1356 CEPATGTCR---CGPGFYGQACEHPCPPGFHGAGCQGLC--------W---CQHGAPCDP 1401
Query: 376 GSYYCTCPVGFVLLPDGKRCHQLVSC-PRNVSE-CSHDCVLTSEGP------LCFCPEGS 427
S C CP GF G C + C P + E C C P LC CP G
Sbjct: 1402 ISGRCLCPAGF----HGHFCER--GCEPGSFGEGCHQRCDCDGGAPCDPVTGLCLCPPG- 1454
Query: 428 VLERDGKTCS-GCSSPDNG-GCSQLC-----VPLSPVSWECDCFPGY 467
R G TC+ C G C+ C PVS +C C GY
Sbjct: 1455 ---RSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGY 1498
Score = 37.7 bits (86), Expect = 0.067
Identities = 47/202 (23%), Positives = 70/202 (34%), Gaps = 59/202 (29%)
Query: 855 CQCLKGFAGDG-----------KLCSDIDECEMGVPVCPPASSKCINTEG--GYVC--RC 899
C+C GF G G + C+ + +C P C PA+ C G G C RC
Sbjct: 1147 CRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQRC 1206
Query: 900 SEGYQGDGIH----CLDIDECQLGEHSC-------GENASCTNTEGGY------TCMCA- 941
G G G CL+ C +C G + + T +G + C C
Sbjct: 1207 PPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQ 1266
Query: 942 GRLSEP---GLICPDSTPPPHLREDDHHYSVRNSDSECPLSHDGY-------CLHDGVCM 991
G +P +CP VR + CP + G C + G+C
Sbjct: 1267 GAACDPVTGTCLCPPGRA-----------GVR-CERGCPQNRFGVGCEHTCSCRNGGLCH 1314
Query: 992 YIEALDKYACNCVVGYIGERCQ 1013
+C+C +G+ G C+
Sbjct: 1315 ASNG----SCSCGLGWTGRHCE 1332
Score = 33.5 bits (75), Expect = 1.3
Identities = 44/171 (25%), Positives = 57/171 (33%), Gaps = 36/171 (21%)
Query: 855 CQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYV------CRCSEGYQGDGI 908
C C +G+AG L + + V S C+N GG C C G+ GD
Sbjct: 1061 CACPEGWAG---LACEKECLPRDVRAGCRHSGGCLN--GGLCDPHTGRCLCPAGWTGDKC 1115
Query: 909 H--CLD--IDECQLGEHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHLREDD 964
CL E SC A+C + G C C + G C + PP ED
Sbjct: 1116 QSPCLRGWFGEACAQRCSCPPGAACHHVTGA--CRCPPGFTGSG--CEQACPPGSFGEDC 1171
Query: 965 HHYSVRNSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYR 1015
+CP + G C +C GY G CQ R
Sbjct: 1172 AQMC------QCPGENPACHPATGTC-----------SCAAGYHGPSCQQR 1205
Score = 32.7 bits (73), Expect = 2.1
Identities = 35/129 (27%), Positives = 45/129 (34%), Gaps = 30/129 (23%)
Query: 339 CMCAEGYALSRDRKYCEDVNECAFWNHGCT--LGCKN----TPGSYYCTCPVGFVLLPDG 392
C CA GY ++ C + GC GC N + C CP GF+ G
Sbjct: 1191 CSCAAGYHGPSCQQRCPPGR----YGPGCEQLCGCLNGGSCDAATGACRCPTGFL----G 1242
Query: 393 KRCHQLVSCPR--------NVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCS-GCSSPD 443
C+ ++CP+ +V C C CP G R G C GC
Sbjct: 1243 TDCN--LTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPG----RAGVRCERGCPQNR 1296
Query: 444 NG-GCSQLC 451
G GC C
Sbjct: 1297 FGVGCEHTC 1305
>gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]
Length = 937
Score = 121 bits (303), Expect = 5e-27
Identities = 61/145 (42%), Positives = 80/145 (55%), Gaps = 5/145 (3%)
Query: 336 SHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRC 395
S+LC C EG+AL+ D+K C ++ CA NHGC C NT SY C C GF L PD K C
Sbjct: 341 SYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTC 400
Query: 396 HQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCS---GCSSPDNGGCSQLCV 452
++ C N C H+CV E C C G L+ +GKTCS C+ D+ GC QLC+
Sbjct: 401 RRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDH-GCEQLCL 459
Query: 453 PLSPVSWECDCFPGYDLQLDEKSCA 477
S+ C C G+ + D K+C+
Sbjct: 460 NTED-SFVCQCSEGFLINEDLKTCS 483
Score = 120 bits (301), Expect = 8e-27
Identities = 65/176 (36%), Positives = 88/176 (50%), Gaps = 12/176 (6%)
Query: 310 TWEPEQKLCKLRKGNCSST------VCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFW 363
T +P K C R +C+ +C S +C C+EG+ ++ D K C V+ C
Sbjct: 433 TLDPNGKTCS-RVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLS 491
Query: 364 NHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFC 423
+HGC C N S+ C CP G VL DGK C +L SC C H CV + + +C C
Sbjct: 492 DHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQC 551
Query: 424 PEGSVLERDGKTC---SGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
EG +L DGKTC C + D+ GC +CV S S+ C+C G+ L D K C
Sbjct: 552 FEGYILREDGKTCRRKDVCQAIDH-GCEHICVN-SDDSYTCECLEGFRLAEDGKRC 605
Score = 117 bits (294), Expect = 5e-26
Identities = 63/165 (38%), Positives = 82/165 (49%), Gaps = 4/165 (2%)
Query: 315 QKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNT 374
Q LC + NC +C S +C C GYAL+ D K C V+ CA NHGC C N
Sbjct: 280 QDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNA 338
Query: 375 PGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGK 434
GSY C C GF L PD K C ++ C + C H+CV T + C C +G L D K
Sbjct: 339 DGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKK 398
Query: 435 TCSGCS--SPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCA 477
TC + + + GC CV + S+ C C GY L + K+C+
Sbjct: 399 TCRRINYCALNKPGCEHECVNMEE-SYYCRCHRGYTLDPNGKTCS 442
Score = 115 bits (289), Expect = 2e-25
Identities = 65/176 (36%), Positives = 87/176 (49%), Gaps = 12/176 (6%)
Query: 310 TWEPEQKLCK------LRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFW 363
T P++K C+ L K C + +S+ C C GY L + K C V+ CA
Sbjct: 392 TLNPDKKTCRRINYCALNKPGCEHECVNME-ESYYCRCHRGYTLDPNGKTCSRVDHCAQQ 450
Query: 364 NHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFC 423
+HGC C NT S+ C C GF++ D K C ++ C + C + CV C C
Sbjct: 451 DHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQC 510
Query: 424 PEGSVLERDGKTCS---GCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
PEG VL DGKTC+ C+ D+ GC CV S S+ C CF GY L+ D K+C
Sbjct: 511 PEGHVLRSDGKTCAKLDSCALGDH-GCEHSCVS-SEDSFVCQCFEGYILREDGKTC 564
Score = 112 bits (281), Expect = 2e-24
Identities = 60/163 (36%), Positives = 80/163 (49%), Gaps = 6/163 (3%)
Query: 317 LCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPG 376
+C + NC+ C S++C C +GY L+ D+ C + CA +H C C N PG
Sbjct: 241 MCSTLEHNCAH-FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPG 299
Query: 377 SYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTC 436
S+ C C G+ L DGKRC + C C H+CV LC C EG L D KTC
Sbjct: 300 SFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTC 359
Query: 437 SG---CSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
+ C+S N GC CV S+ C C G+ L D+K+C
Sbjct: 360 TKIDYCAS-SNHGCQHECVNTDD-SYSCHCLKGFTLNPDKKTC 400
Score = 107 bits (266), Expect = 9e-23
Identities = 83/302 (27%), Positives = 118/302 (39%), Gaps = 40/302 (13%)
Query: 743 DPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTP 802
D C ++ CE +C G+ C C G+ A DGK C+A+D A +++
Sbjct: 281 DLCAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVD---YCASENHGCEHECVN 337
Query: 803 LDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQCLKGFA 862
D + E +I D CA C++ + +C CLKGF
Sbjct: 338 ADGSYLCQCHEGFALNPDKKTCTKI-----DYCASSNHGCQHECVNTDDSYSCHCLKGFT 392
Query: 863 --GDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGD--GIHCLDIDECQL 918
D K C I+ C + P C +C+N E Y CRC GY D G C +D C
Sbjct: 393 LNPDKKTCRRINYCALNKPGC---EHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQ 449
Query: 919 GEHSCGENASCTNTEGGYTCMCA-GRLSEPGLICPDSTPPPHLREDDHHYSVRNSD---- 973
+H C + C NTE + C C+ G L L L + YS N D
Sbjct: 450 QDHGCEQ--LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFA 507
Query: 974 SECPLSH------------DGYCLHDGVCMY--IEALDKYACNCVVGYI----GERCQYR 1015
+CP H D L D C + + + D + C C GYI G+ C+ +
Sbjct: 508 CQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRK 567
Query: 1016 DL 1017
D+
Sbjct: 568 DV 569
Score = 104 bits (260), Expect = 4e-22
Identities = 60/174 (34%), Positives = 87/174 (50%), Gaps = 12/174 (6%)
Query: 313 PEQKLCKLRKGNCSST------VCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHG 366
P++K C + C+S+ C S+ C C +G+ L+ D+K C +N CA G
Sbjct: 354 PDKKTCT-KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPG 412
Query: 367 CTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEG 426
C C N SYYC C G+ L P+GK C ++ C + C C+ T + +C C EG
Sbjct: 413 CEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEG 472
Query: 427 SVLERDGKTCSG---CSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCA 477
++ D KTCS C D+ GC CV + S+ C C G+ L+ D K+CA
Sbjct: 473 FLINEDLKTCSRVDYCLLSDH-GCEYSCVNMDR-SFACQCPEGHVLRSDGKTCA 524
Score = 103 bits (256), Expect = 1e-21
Identities = 85/310 (27%), Positives = 119/310 (38%), Gaps = 56/310 (18%)
Query: 743 DPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTP 802
D C +N GCEH C G+ C C EGF D KTC +D A +++
Sbjct: 322 DYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKID---YCASSNHGCQHECVN 378
Query: 803 LDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPV--------GCSMYARCISEGEDAT 854
D + S H L + D+ C + GC C++ E
Sbjct: 379 TD-----------DSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCE--HECVNMEESYY 425
Query: 855 CQCLKGFAGD--GKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGY--QGDGIHC 910
C+C +G+ D GK CS +D C C C+NTE +VC+CSEG+ D C
Sbjct: 426 CRCHRGYTLDPNGKTCSRVDHCAQQDHGC---EQLCLNTEDSFVCQCSEGFLINEDLKTC 482
Query: 911 LDIDECQLGEHSCGENASCTNTEGGYTCMC--AGRLSEPGLICPDSTPPPHLREDDHHYS 968
+D C L +H C SC N + + C C L G C H
Sbjct: 483 SRVDYCLLSDHGC--EYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC 540
Query: 969 VRNSDSECPLSHDGY--------CLHDGVCMYIE---------ALDKYACNCVVGY---- 1007
V + DS +GY C VC I+ + D Y C C+ G+
Sbjct: 541 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE 600
Query: 1008 IGERCQYRDL 1017
G+RC+ +D+
Sbjct: 601 DGKRCRRKDV 610
Score = 93.2 bits (230), Expect = 1e-18
Identities = 47/123 (38%), Positives = 56/123 (45%), Gaps = 1/123 (0%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGS 377
C L C + C S +C C EGY L D K C + C +HGC C N+ S
Sbjct: 529 CALGDHGCEHS-CVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDS 587
Query: 378 YYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCS 437
Y C C GF L DGKRC + C C H CV +C C EG VL DG+ C
Sbjct: 588 YTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCK 647
Query: 438 GCS 440
C+
Sbjct: 648 KCT 650
Score = 73.9 bits (180), Expect = 8e-13
Identities = 70/296 (23%), Positives = 101/296 (34%), Gaps = 80/296 (27%)
Query: 716 KDRVRLQGSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKAS 775
+D V L + + +L V A C C H C G+ C C++G++ S
Sbjct: 213 EDHVFLVANFSQIETLTSVFQKKLCTAHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNS 272
Query: 776 DGKTCLALDGHQLLAGGEVDLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDC 835
D TC QD C
Sbjct: 273 DQTTCRI-------------------------------------------------QDLC 283
Query: 836 APVGCSMYARCISEGEDATCQCLKGF--AGDGKLCSDIDECEMGVPVCPPASSKCINTEG 893
A + C++ CQC G+ A DGK C +D C C +C+N +G
Sbjct: 284 AMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGC---EHECVNADG 340
Query: 894 GYVCRCSEGY--QGDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMCAGRLSEPGLIC 951
Y+C+C EG+ D C ID C H C C NT+ Y+C C + +
Sbjct: 341 SYLCQCHEGFALNPDKKTCTKIDYCASSNHGC--QHECVNTDDSYSCHCLKGFT----LN 394
Query: 952 PDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGY 1007
PD + + C L+ G C H+ C+ +E + Y C C GY
Sbjct: 395 PDKKTCRRI-------------NYCALNKPG-CEHE--CVNME--ESYYCRCHRGY 432
Score = 73.9 bits (180), Expect = 8e-13
Identities = 51/172 (29%), Positives = 72/172 (41%), Gaps = 15/172 (8%)
Query: 743 DPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTP 802
D CL + GCE+ C + C C EG + SDGKTC LD L G+ ++
Sbjct: 486 DYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCAL---GDHGCEHSCVS 542
Query: 803 LDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQCLKGF- 861
+ + E I +D C + C++ + TC+CL+GF
Sbjct: 543 SEDSFVCQCFEGYILREDGKTCRR-----KDVCQAIDHGCEHICVNSDDSYTCECLEGFR 597
Query: 862 -AGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGY--QGDGIHC 910
A DGK C D C+ C C+N Y+C+CSEG+ DG C
Sbjct: 598 LAEDGKRCRRKDVCKSTHHGCEHI---CVNNGNSYICKCSEGFVLAEDGRRC 646
Score = 65.9 bits (159), Expect = 2e-10
Identities = 34/93 (36%), Positives = 44/93 (47%), Gaps = 7/93 (7%)
Query: 316 KLCKLRKGNCSST------VCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTL 369
K C+ RK C + +C S+ C C EG+ L+ D K C + C +HGC
Sbjct: 562 KTCR-RKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEH 620
Query: 370 GCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCP 402
C N SY C C GFVL DG+RC + P
Sbjct: 621 ICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGP 653
Score = 52.4 bits (124), Expect = 3e-06
Identities = 29/81 (35%), Positives = 39/81 (48%), Gaps = 5/81 (6%)
Query: 401 CPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTC---SGCSSPDNGGCSQLCVPLSPV 457
C C+H C+ +C C +G +L D TC C+ D+ C QLCV + P
Sbjct: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHN-CEQLCVNV-PG 299
Query: 458 SWECDCFPGYDLQLDEKSCAA 478
S+ C C+ GY L D K C A
Sbjct: 300 SFVCQCYSGYALAEDGKRCVA 320
>gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]
Length = 956
Score = 121 bits (303), Expect = 5e-27
Identities = 61/145 (42%), Positives = 80/145 (55%), Gaps = 5/145 (3%)
Query: 336 SHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRC 395
S+LC C EG+AL+ D+K C ++ CA NHGC C NT SY C C GF L PD K C
Sbjct: 341 SYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTC 400
Query: 396 HQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCS---GCSSPDNGGCSQLCV 452
++ C N C H+CV E C C G L+ +GKTCS C+ D+ GC QLC+
Sbjct: 401 RRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDH-GCEQLCL 459
Query: 453 PLSPVSWECDCFPGYDLQLDEKSCA 477
S+ C C G+ + D K+C+
Sbjct: 460 NTED-SFVCQCSEGFLINEDLKTCS 483
Score = 120 bits (301), Expect = 8e-27
Identities = 65/176 (36%), Positives = 88/176 (50%), Gaps = 12/176 (6%)
Query: 310 TWEPEQKLCKLRKGNCSST------VCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFW 363
T +P K C R +C+ +C S +C C+EG+ ++ D K C V+ C
Sbjct: 433 TLDPNGKTCS-RVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLS 491
Query: 364 NHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFC 423
+HGC C N S+ C CP G VL DGK C +L SC C H CV + + +C C
Sbjct: 492 DHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQC 551
Query: 424 PEGSVLERDGKTC---SGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
EG +L DGKTC C + D+ GC +CV S S+ C+C G+ L D K C
Sbjct: 552 FEGYILREDGKTCRRKDVCQAIDH-GCEHICVN-SDDSYTCECLEGFRLAEDGKRC 605
Score = 117 bits (294), Expect = 5e-26
Identities = 63/165 (38%), Positives = 82/165 (49%), Gaps = 4/165 (2%)
Query: 315 QKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNT 374
Q LC + NC +C S +C C GYAL+ D K C V+ CA NHGC C N
Sbjct: 280 QDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNA 338
Query: 375 PGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGK 434
GSY C C GF L PD K C ++ C + C H+CV T + C C +G L D K
Sbjct: 339 DGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKK 398
Query: 435 TCSGCS--SPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCA 477
TC + + + GC CV + S+ C C GY L + K+C+
Sbjct: 399 TCRRINYCALNKPGCEHECVNMEE-SYYCRCHRGYTLDPNGKTCS 442
Score = 115 bits (289), Expect = 2e-25
Identities = 65/176 (36%), Positives = 87/176 (49%), Gaps = 12/176 (6%)
Query: 310 TWEPEQKLCK------LRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFW 363
T P++K C+ L K C + +S+ C C GY L + K C V+ CA
Sbjct: 392 TLNPDKKTCRRINYCALNKPGCEHECVNME-ESYYCRCHRGYTLDPNGKTCSRVDHCAQQ 450
Query: 364 NHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFC 423
+HGC C NT S+ C C GF++ D K C ++ C + C + CV C C
Sbjct: 451 DHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQC 510
Query: 424 PEGSVLERDGKTCS---GCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
PEG VL DGKTC+ C+ D+ GC CV S S+ C CF GY L+ D K+C
Sbjct: 511 PEGHVLRSDGKTCAKLDSCALGDH-GCEHSCVS-SEDSFVCQCFEGYILREDGKTC 564
Score = 112 bits (281), Expect = 2e-24
Identities = 60/163 (36%), Positives = 80/163 (49%), Gaps = 6/163 (3%)
Query: 317 LCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPG 376
+C + NC+ C S++C C +GY L+ D+ C + CA +H C C N PG
Sbjct: 241 MCSTLEHNCAH-FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPG 299
Query: 377 SYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTC 436
S+ C C G+ L DGKRC + C C H+CV LC C EG L D KTC
Sbjct: 300 SFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTC 359
Query: 437 SG---CSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
+ C+S N GC CV S+ C C G+ L D+K+C
Sbjct: 360 TKIDYCAS-SNHGCQHECVNTDD-SYSCHCLKGFTLNPDKKTC 400
Score = 107 bits (266), Expect = 9e-23
Identities = 83/302 (27%), Positives = 118/302 (39%), Gaps = 40/302 (13%)
Query: 743 DPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTP 802
D C ++ CE +C G+ C C G+ A DGK C+A+D A +++
Sbjct: 281 DLCAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVD---YCASENHGCEHECVN 337
Query: 803 LDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQCLKGFA 862
D + E +I D CA C++ + +C CLKGF
Sbjct: 338 ADGSYLCQCHEGFALNPDKKTCTKI-----DYCASSNHGCQHECVNTDDSYSCHCLKGFT 392
Query: 863 --GDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGD--GIHCLDIDECQL 918
D K C I+ C + P C +C+N E Y CRC GY D G C +D C
Sbjct: 393 LNPDKKTCRRINYCALNKPGC---EHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQ 449
Query: 919 GEHSCGENASCTNTEGGYTCMCA-GRLSEPGLICPDSTPPPHLREDDHHYSVRNSD---- 973
+H C + C NTE + C C+ G L L L + YS N D
Sbjct: 450 QDHGCEQ--LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFA 507
Query: 974 SECPLSH------------DGYCLHDGVCMY--IEALDKYACNCVVGYI----GERCQYR 1015
+CP H D L D C + + + D + C C GYI G+ C+ +
Sbjct: 508 CQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRK 567
Query: 1016 DL 1017
D+
Sbjct: 568 DV 569
Score = 104 bits (260), Expect = 4e-22
Identities = 60/174 (34%), Positives = 87/174 (50%), Gaps = 12/174 (6%)
Query: 313 PEQKLCKLRKGNCSST------VCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHG 366
P++K C + C+S+ C S+ C C +G+ L+ D+K C +N CA G
Sbjct: 354 PDKKTCT-KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPG 412
Query: 367 CTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEG 426
C C N SYYC C G+ L P+GK C ++ C + C C+ T + +C C EG
Sbjct: 413 CEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEG 472
Query: 427 SVLERDGKTCSG---CSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCA 477
++ D KTCS C D+ GC CV + S+ C C G+ L+ D K+CA
Sbjct: 473 FLINEDLKTCSRVDYCLLSDH-GCEYSCVNMDR-SFACQCPEGHVLRSDGKTCA 524
Score = 103 bits (256), Expect = 1e-21
Identities = 85/310 (27%), Positives = 119/310 (38%), Gaps = 56/310 (18%)
Query: 743 DPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTP 802
D C +N GCEH C G+ C C EGF D KTC +D A +++
Sbjct: 322 DYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKID---YCASSNHGCQHECVN 378
Query: 803 LDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPV--------GCSMYARCISEGEDAT 854
D + S H L + D+ C + GC C++ E
Sbjct: 379 TD-----------DSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCE--HECVNMEESYY 425
Query: 855 CQCLKGFAGD--GKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGY--QGDGIHC 910
C+C +G+ D GK CS +D C C C+NTE +VC+CSEG+ D C
Sbjct: 426 CRCHRGYTLDPNGKTCSRVDHCAQQDHGC---EQLCLNTEDSFVCQCSEGFLINEDLKTC 482
Query: 911 LDIDECQLGEHSCGENASCTNTEGGYTCMC--AGRLSEPGLICPDSTPPPHLREDDHHYS 968
+D C L +H C SC N + + C C L G C H
Sbjct: 483 SRVDYCLLSDHGC--EYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC 540
Query: 969 VRNSDSECPLSHDGY--------CLHDGVCMYIE---------ALDKYACNCVVGY---- 1007
V + DS +GY C VC I+ + D Y C C+ G+
Sbjct: 541 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE 600
Query: 1008 IGERCQYRDL 1017
G+RC+ +D+
Sbjct: 601 DGKRCRRKDV 610
Score = 93.2 bits (230), Expect = 1e-18
Identities = 47/123 (38%), Positives = 56/123 (45%), Gaps = 1/123 (0%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGS 377
C L C + C S +C C EGY L D K C + C +HGC C N+ S
Sbjct: 529 CALGDHGCEHS-CVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDS 587
Query: 378 YYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCS 437
Y C C GF L DGKRC + C C H CV +C C EG VL DG+ C
Sbjct: 588 YTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCK 647
Query: 438 GCS 440
C+
Sbjct: 648 KCT 650
Score = 73.9 bits (180), Expect = 8e-13
Identities = 70/296 (23%), Positives = 101/296 (34%), Gaps = 80/296 (27%)
Query: 716 KDRVRLQGSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKAS 775
+D V L + + +L V A C C H C G+ C C++G++ S
Sbjct: 213 EDHVFLVANFSQIETLTSVFQKKLCTAHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNS 272
Query: 776 DGKTCLALDGHQLLAGGEVDLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDC 835
D TC QD C
Sbjct: 273 DQTTCRI-------------------------------------------------QDLC 283
Query: 836 APVGCSMYARCISEGEDATCQCLKGF--AGDGKLCSDIDECEMGVPVCPPASSKCINTEG 893
A + C++ CQC G+ A DGK C +D C C +C+N +G
Sbjct: 284 AMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGC---EHECVNADG 340
Query: 894 GYVCRCSEGY--QGDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMCAGRLSEPGLIC 951
Y+C+C EG+ D C ID C H C C NT+ Y+C C + +
Sbjct: 341 SYLCQCHEGFALNPDKKTCTKIDYCASSNHGC--QHECVNTDDSYSCHCLKGFT----LN 394
Query: 952 PDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGY 1007
PD + + C L+ G C H+ C+ +E + Y C C GY
Sbjct: 395 PDKKTCRRI-------------NYCALNKPG-CEHE--CVNME--ESYYCRCHRGY 432
Score = 73.9 bits (180), Expect = 8e-13
Identities = 51/172 (29%), Positives = 72/172 (41%), Gaps = 15/172 (8%)
Query: 743 DPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTP 802
D CL + GCE+ C + C C EG + SDGKTC LD L G+ ++
Sbjct: 486 DYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCAL---GDHGCEHSCVS 542
Query: 803 LDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQCLKGF- 861
+ + E I +D C + C++ + TC+CL+GF
Sbjct: 543 SEDSFVCQCFEGYILREDGKTCRR-----KDVCQAIDHGCEHICVNSDDSYTCECLEGFR 597
Query: 862 -AGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGY--QGDGIHC 910
A DGK C D C+ C C+N Y+C+CSEG+ DG C
Sbjct: 598 LAEDGKRCRRKDVCKSTHHGCEHI---CVNNGNSYICKCSEGFVLAEDGRRC 646
Score = 65.9 bits (159), Expect = 2e-10
Identities = 34/93 (36%), Positives = 44/93 (47%), Gaps = 7/93 (7%)
Query: 316 KLCKLRKGNCSST------VCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTL 369
K C+ RK C + +C S+ C C EG+ L+ D K C + C +HGC
Sbjct: 562 KTCR-RKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEH 620
Query: 370 GCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCP 402
C N SY C C GFVL DG+RC + P
Sbjct: 621 ICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGP 653
Score = 52.4 bits (124), Expect = 3e-06
Identities = 29/81 (35%), Positives = 39/81 (48%), Gaps = 5/81 (6%)
Query: 401 CPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTC---SGCSSPDNGGCSQLCVPLSPV 457
C C+H C+ +C C +G +L D TC C+ D+ C QLCV + P
Sbjct: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHN-CEQLCVNV-PG 299
Query: 458 SWECDCFPGYDLQLDEKSCAA 478
S+ C C+ GY L D K C A
Sbjct: 300 SFVCQCYSGYALAEDGKRCVA 320
>gi|24430141 fibrillin 1 precursor [Homo sapiens]
Length = 2871
Score = 120 bits (302), Expect = 6e-27
Identities = 84/282 (29%), Positives = 121/282 (42%), Gaps = 46/282 (16%)
Query: 743 DPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALD----GHQLLAGGEVDLKN 798
D C NGGCE C G+ CSC+ GF D ++C +D + GG+
Sbjct: 1199 DECSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNICDGGQCT--- 1255
Query: 799 QVTPLDILSKTR-VSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQC 857
+I + R + D S+ M + ++ D P C + C + C C
Sbjct: 1256 -----NIPGEYRCLCYDGFMASEDMKTCVDV--NECDLNPNIC-LSGTCENTKGSFICHC 1307
Query: 858 LKGFAGD-GKL-CSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCLDIDE 915
G++G GK C+DI+ECE+G C + C NT G + C CS G+ GDGI C D+DE
Sbjct: 1308 DMGYSGKKGKTGCTDINECEIGAHNCGK-HAVCTNTAGSFKCSCSPGWIGDGIKCTDLDE 1366
Query: 916 CQLGEHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSE 975
C G H C ++A C NT G Y C+C + G C D +
Sbjct: 1367 CSNGTHMCSQHADCKNTMGSYRCLCKEGYTGDGFTCTD---------------LDECSEN 1411
Query: 976 CPLSHDGYCLHDGVCMYIEALDKYACNCVVGYI----GERCQ 1013
L +G CL+ A Y C C +G++ G+ C+
Sbjct: 1412 LNLCGNGQCLN--------APGGYRCECDMGFVPSADGKACE 1445
Score = 95.9 bits (237), Expect = 2e-19
Identities = 55/162 (33%), Positives = 73/162 (45%), Gaps = 5/162 (3%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGS 377
CK+ C + C D S+ C+C GY C D+NEC C CKNT GS
Sbjct: 2406 CKVIHDVCRNGECVNDRGSYHCICKTGYTPDITGTSCVDLNECNQAPKPCNFICKNTEGS 2465
Query: 378 YYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTC- 436
Y C+CP G++L DG+ C L C C CV T G C CP G + +C
Sbjct: 2466 YQCSCPKGYILQEDGRSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPG--FTQHHTSCI 2523
Query: 437 --SGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
+ C+S N S+ +P S+ C+C G+ L SC
Sbjct: 2524 DNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSC 2565
Score = 90.5 bits (223), Expect = 9e-18
Identities = 54/164 (32%), Positives = 76/164 (46%), Gaps = 16/164 (9%)
Query: 322 KGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLG-CKNTPGSYYC 380
K C+ C + S+ C C GY + R C D++EC C G C NT GS++C
Sbjct: 496 KNPCAGGECINNQGSYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHC 555
Query: 381 TCPVGFVLLPDGKRCHQLVSCP-RNVSECSHDCVLTSEGPL-CFCPEGSVLERDGKTC-- 436
C GF + DGK C + C RN+ C + + +G C C G L DG+ C
Sbjct: 556 VCNAGFHVTRDGKNCEDMDECSIRNM--CLNGMCINEDGSFKCICKPGFQLASDGRYCKD 613
Query: 437 -SGCSSPD---NGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
+ C +P NG C + S+ C+CFPG + LD + C
Sbjct: 614 INECETPGICMNGRCVN-----TDGSYRCECFPGLAVGLDGRVC 652
Score = 90.5 bits (223), Expect = 9e-18
Identities = 78/294 (26%), Positives = 125/294 (42%), Gaps = 51/294 (17%)
Query: 752 CEH-ICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAG--GEVDLKNQVTPLDILSK 808
C H C+ +G+ C C GF S+ + C +D ++ G N TP D K
Sbjct: 1039 CTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCGRGQCVN--TPGDFECK 1096
Query: 809 TRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQCLKG--FAGDGK 866
D ES M++ M D+ P+ C +EG C+C G + +
Sbjct: 1097 C----DEGYESGFMMMKNCMDIDECQRDPLLCRGGVCHNTEGS-YRCECPPGHQLSPNIS 1151
Query: 867 LCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQG--DGIHCLDIDECQLGEHSCG 924
C DI+ECE+ +CP + +C+N G Y C C+ GY D + C+DIDEC + C
Sbjct: 1152 ACIDINECELSAHLCP--NGRCVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGGC- 1208
Query: 925 ENASCTNTEGGYTCMCAGRLSEPGL-ICPDSTPPPHLREDDHHYSVRNSDSECP------ 977
CTN+EG Y C C +PG + PD + E + + ++ + +C
Sbjct: 1209 -ETFCTNSEGSYECSC-----QPGFALMPDQRSCTDIDECEDNPNICDG-GQCTNIPGEY 1261
Query: 978 --LSHDGYCLHDGV--CMYIEALD----------------KYACNCVVGYIGER 1011
L +DG+ + + C+ + D + C+C +GY G++
Sbjct: 1262 RCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGSFICHCDMGYSGKK 1315
Score = 90.1 bits (222), Expect = 1e-17
Identities = 51/163 (31%), Positives = 73/163 (44%), Gaps = 5/163 (3%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGS 377
C+L C + C + + C C GY + DR +C D++EC+ N GC C N+ GS
Sbjct: 1159 CELSAHLCPNGRCVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGGCETFCTNSEGS 1218
Query: 378 YYCTCPVGFVLLPDGKRCHQLVSCPRNVSEC-SHDCVLTSEGPLCFCPEGSVLERDGKTC 436
Y C+C GF L+PD + C + C N + C C C C +G + D KTC
Sbjct: 1219 YECSCQPGFALMPDQRSCTDIDECEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTC 1278
Query: 437 ---SGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
+ C N S C + S+ C C GY + + C
Sbjct: 1279 VDVNECDLNPNICLSGTC-ENTKGSFICHCDMGYSGKKGKTGC 1320
Score = 87.4 bits (215), Expect = 7e-17
Identities = 63/209 (30%), Positives = 91/209 (43%), Gaps = 20/209 (9%)
Query: 752 CEH-ICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLDILSKTR 810
C H C +G+ +C C GF D CL ++ + A G +N + + R
Sbjct: 1860 CSHGQCIDTVGSFYCLCHTGFKTNDDQTMCLDINECERDACGNGTCRNTIGSFNC----R 1915
Query: 811 VSEDNITESQHMLVAEIMVSDQDDCAPVGCSMY--ARCISEGEDATCQCLKGF--AGDGK 866
+ I + + D D+CA ++ +CI+ CQC +G+ A DG+
Sbjct: 1916 CNHGFILSHNNDCI------DVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGR 1969
Query: 867 LCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCLDIDECQLGEHSCGEN 926
C DI+EC + C P + C N +G Y C C GY C DIDEC C
Sbjct: 1970 TCVDINECLLEPRKCAPGT--CQNLDGSYRCICPPGYSLQNEKCEDIDECVEEPEICA-L 2026
Query: 927 ASCTNTEGGYTCMC--AGRLSEPGLICPD 953
+C+NTEG + C+C LS G C D
Sbjct: 2027 GTCSNTEGSFKCLCPEGFSLSSSGRRCQD 2055
Score = 83.6 bits (205), Expect = 1e-15
Identities = 55/170 (32%), Positives = 71/170 (41%), Gaps = 20/170 (11%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGC--TLGCKNTP 375
C L C S C S +C C GY+ + + C D+NEC H C C NT
Sbjct: 1284 CDLNPNICLSGTCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTA 1343
Query: 376 GSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSH--DCVLTSEGPLCFCPEGSVLERDG 433
GS+ C+C G++ DG +C L C CS DC T C C EG DG
Sbjct: 1344 GSFKCSCSPGWI--GDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEG--YTGDG 1399
Query: 434 KTCSG---CSSP----DNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
TC+ CS NG C +P + C+C G+ D K+C
Sbjct: 1400 FTCTDLDECSENLNLCGNGQCLN-----APGGYRCECDMGFVPSADGKAC 1444
Score = 82.4 bits (202), Expect = 2e-15
Identities = 69/287 (24%), Positives = 114/287 (39%), Gaps = 54/287 (18%)
Query: 743 DPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTP 802
DP L + G +C G+ C C G + + C+ ++ E +L + P
Sbjct: 1120 DPLLCRGG----VCHNTEGSYRCECPPGHQLSPNISACIDIN--------ECELSAHLCP 1167
Query: 803 ----LDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQCL 858
++++ K + + H + D D+C+ + C + C C
Sbjct: 1168 NGRCVNLIGKYQCA---CNPGYHSTPDRLFCVDIDECSIMNGGCETFCTNSEGSYECSCQ 1224
Query: 859 KGFA--GDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQG--DGIHCLDID 914
GFA D + C+DIDECE +C +C N G Y C C +G+ D C+D++
Sbjct: 1225 PGFALMPDQRSCTDIDECEDNPNICD--GGQCTNIPGEYRCLCYDGFMASEDMKTCVDVN 1282
Query: 915 ECQLGEHSCGENASCTNTEGGYTCMC----AGRLSEPGLICPDSTPPPHLREDDHHYSVR 970
EC L + C + +C NT+G + C C +G+ + G C D
Sbjct: 1283 ECDLNPNIC-LSGTCENTKGSFICHCDMGYSGKKGKTG--CTDI---------------- 1323
Query: 971 NSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDL 1017
+EC + C VC + C+C G+IG+ + DL
Sbjct: 1324 ---NECEIGAHN-CGKHAVCT--NTAGSFKCSCSPGWIGDGIKCTDL 1364
Score = 82.4 bits (202), Expect = 2e-15
Identities = 63/199 (31%), Positives = 89/199 (44%), Gaps = 27/199 (13%)
Query: 752 CEH-ICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQV---TPLDILS 807
C+H C G+ C C G++ A G C+ D E + N T +++
Sbjct: 2137 CKHGQCINTDGSYRCECPFGYILA--GNECVDTD--------ECSVGNPCGNGTCKNVIG 2186
Query: 808 KTRVSEDNITESQHMLVAEIMVSDQDDCA--PVGCSMYARCISEGEDATCQCLKGFA--G 863
+ + E M+ E D ++CA P+ C+ RC++ C+C G+
Sbjct: 2187 GFECTCEEGFEPGPMMTCE----DINECAQNPLLCAF--RCVNTYGSYECKCPVGYVLRE 2240
Query: 864 DGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQ--GDGIHCLDIDECQLGEH 921
D ++C D DECE G C +C N G Y+C C GYQ DG C+D +ECQ
Sbjct: 2241 DRRMCKDEDECEEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCVDENECQTKPG 2300
Query: 922 SCGENASCTNTEGGYTCMC 940
C EN C NT G YTC C
Sbjct: 2301 IC-ENGRCLNTRGSYTCEC 2318
Score = 81.3 bits (199), Expect = 5e-15
Identities = 51/165 (30%), Positives = 66/165 (40%), Gaps = 21/165 (12%)
Query: 318 CKLRKGN-CSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLG-CKNTP 375
C GN C + C + S C C EGY ++ D + C D+NEC C G C+N
Sbjct: 1934 CASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECLLEPRKCAPGTCQNLD 1993
Query: 376 GSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPL-CFCPEGSVLERDGK 434
GSY C CP G+ L ++C + C C+ +EG C CPEG L G+
Sbjct: 1994 GSYRCICPPGYSL--QNEKCEDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSSGR 2051
Query: 435 TCSG--------------CSSPD--NGGCSQLCVPLSPVSWECDC 463
C CSSP N + C L W C
Sbjct: 2052 RCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGEGWGDPC 2096
Score = 80.5 bits (197), Expect = 9e-15
Identities = 61/210 (29%), Positives = 82/210 (39%), Gaps = 56/210 (26%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLG-CKNTPG 376
CK+ C+ C + S C C G+AL + + C D++EC C G C NTPG
Sbjct: 1032 CKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCGRGQCVNTPG 1091
Query: 377 SYYCTCPVGF-------------------VLLPDGKRCHQL-----VSCP------RNVS 406
+ C C G+ LL G CH CP N+S
Sbjct: 1092 DFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGVCHNTEGSYRCECPPGHQLSPNIS 1151
Query: 407 EC--SHDCVLTSEGPLCFCPEGSVLERDGKTCSGC-----SSPD-------------NGG 446
C ++C L++ CP G + GK C S+PD NGG
Sbjct: 1152 ACIDINECELSAH----LCPNGRCVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGG 1207
Query: 447 CSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
C C S S+EC C PG+ L D++SC
Sbjct: 1208 CETFCTN-SEGSYECSCQPGFALMPDQRSC 1236
Score = 79.7 bits (195), Expect = 2e-14
Identities = 46/114 (40%), Positives = 57/114 (50%), Gaps = 10/114 (8%)
Query: 845 RCISEGEDATCQCLKGFAGDGK-LCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGY 903
RCI C+C KGF D + C D+DECE P A +CIN +G Y C+C GY
Sbjct: 464 RCIPTPGSCRCECNKGFQLDLRGECIDVDECEKN----PCAGGECINNQGSYTCQCRAGY 519
Query: 904 QG--DGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMC-AG-RLSEPGLICPD 953
Q C DIDEC C N C NT+G + C+C AG ++ G C D
Sbjct: 520 QSTLTRTECRDIDECLQNGRIC-NNGRCINTDGSFHCVCNAGFHVTRDGKNCED 572
Score = 79.3 bits (194), Expect = 2e-14
Identities = 46/137 (33%), Positives = 63/137 (45%), Gaps = 7/137 (5%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLG-CKNTPG 376
C L C + +C ++ C+C GY + K C D+NEC + C G C+NTPG
Sbjct: 727 CALDPDICPNGICENLRGTYKCICNSGYEVDSTGKNCVDINECVLNSLLCDNGQCRNTPG 786
Query: 377 SYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGP-LCFCPEGSVLERDGKT 435
S+ CTCP GF+ PD K C + C S C + S G +C C S L+ T
Sbjct: 787 SFVCTCPKGFIYKPDLKTCEDIDEC--ESSPCINGVCKNSPGSFICECSSESTLD---PT 841
Query: 436 CSGCSSPDNGGCSQLCV 452
+ C G C Q +
Sbjct: 842 KTICIETIKGTCWQTVI 858
Score = 78.6 bits (192), Expect = 3e-14
Identities = 55/184 (29%), Positives = 75/184 (40%), Gaps = 36/184 (19%)
Query: 831 DQDDC--APVGCSMYARCISEGEDATCQCLKGFA--GDGKLCSDIDECEMGVPVCPPASS 886
D ++C AP C+ C + C C KG+ DG+ C D+DEC C
Sbjct: 2444 DLNECNQAPKPCNFI--CKNTEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNC---QF 2498
Query: 887 KCINTEGGYVCRCSEGYQGDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMC--AGRL 944
C+NT GG+ C+C G+ C+D +EC + CG C NT G +TC C L
Sbjct: 2499 LCVNTIGGFTCKCPPGFTQHHTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSL 2558
Query: 945 SEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCLHDGVCMYIEALDKYACNCV 1004
+ G C D EC +H C H C I + Y C+C
Sbjct: 2559 DQTGSSCEDV-------------------DECEGNH--RCQHG--CQNI--IGGYRCSCP 2593
Query: 1005 VGYI 1008
GY+
Sbjct: 2594 QGYL 2597
Score = 78.2 bits (191), Expect = 4e-14
Identities = 60/200 (30%), Positives = 86/200 (43%), Gaps = 26/200 (13%)
Query: 749 NGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALD---GHQLLAGGEVDLKNQVTPLDI 805
N G +C G+ CSC G++ DG C LD + D KN +
Sbjct: 1332 NCGKHAVCTNTAGSFKCSCSPGWI--GDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRC 1389
Query: 806 LSKTRVSEDNITESQHMLVAEIMVSDQDDCAP-VGCSMYARCISEGEDATCQCLKGF--A 862
L K + D T +D D+C+ + +C++ C+C GF +
Sbjct: 1390 LCKEGYTGDGFT-----------CTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPS 1438
Query: 863 GDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGD--GIHCLDIDECQLGE 920
DGK C DIDEC + +C C N G + C C GY+ D G +C D++EC L
Sbjct: 1439 ADGKACEDIDECSL-PNIC--VFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNEC-LDP 1494
Query: 921 HSCGENASCTNTEGGYTCMC 940
+C + +C NT G Y C C
Sbjct: 1495 TTC-ISGNCVNTPGSYICDC 1513
Score = 77.0 bits (188), Expect = 1e-13
Identities = 63/258 (24%), Positives = 97/258 (37%), Gaps = 44/258 (17%)
Query: 756 CKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLDILSKTRVSEDN 815
C G+ C C+ G+ G +C+ L+ + P + + K
Sbjct: 2418 CVNDRGSYHCICKTGYTPDITGTSCVDLN----------ECNQAPKPCNFICKNTEGSYQ 2467
Query: 816 ITESQHMLVAE--IMVSDQDDCAPVGCSMYARCISEGEDATCQCLKGFAGDGKLCSDIDE 873
+ + ++ E D D+CA + C++ TC+C GF C D +E
Sbjct: 2468 CSCPKGYILQEDGRSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPGFTQHHTSCIDNNE 2527
Query: 874 CEMGVPVCPPASSKCINTEGGYVCRCSEGYQGD--GIHCLDIDECQLGEHSCGENASCTN 931
C + +C + C NT G + C C G+ D G C D+DEC+ G H C C N
Sbjct: 2528 CTSDINLC-GSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDECE-GNHRC--QHGCQN 2583
Query: 932 TEGGYTCMCAGRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLSH--DGYCLHDGV 989
GGY C C P +L+ + V ++EC +H G H+
Sbjct: 2584 IIGGYRCSC---------------PQGYLQHYQWNQCV--DENECLSAHICGGASCHN-- 2624
Query: 990 CMYIEALDKYACNCVVGY 1007
L Y C C G+
Sbjct: 2625 -----TLGSYKCMCPAGF 2637
Score = 76.6 bits (187), Expect = 1e-13
Identities = 69/220 (31%), Positives = 99/220 (45%), Gaps = 34/220 (15%)
Query: 746 LYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQL--LAGGEVDLKNQVTPL 803
L QNG C G+ C C +GF G+ C+ +D + AGGE + NQ +
Sbjct: 459 LCQNGRCI----PTPGSCRCECNKGFQLDLRGE-CIDVDECEKNPCAGGEC-INNQGS-- 510
Query: 804 DILSKTRVS-EDNITESQHMLVAEIMVSDQDDCAPVG--CSMYARCISEGEDATCQCLKG 860
+ R + +T ++ D D+C G C+ RCI+ C C G
Sbjct: 511 -YTCQCRAGYQSTLTRTE--------CRDIDECLQNGRICNN-GRCINTDGSFHCVCNAG 560
Query: 861 F--AGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQ--GDGIHCLDIDEC 916
F DGK C D+DEC + +C + CIN +G + C C G+Q DG +C DI+EC
Sbjct: 561 FHVTRDGKNCEDMDECSIR-NMC--LNGMCINEDGSFKCICKPGFQLASDGRYCKDINEC 617
Query: 917 QLGEHSCGENASCTNTEGGYTCMCAGRLSE--PGLICPDS 954
+ N C NT+G Y C C L+ G +C D+
Sbjct: 618 E--TPGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDT 655
Score = 74.7 bits (182), Expect = 5e-13
Identities = 75/295 (25%), Positives = 114/295 (38%), Gaps = 42/295 (14%)
Query: 727 KPSSLVVVHPLAKPGADPCLYQNGGCEH-ICKKRLGTAWCSCREGFMKASDGKTCLALDG 785
+P ++ ++ D C G CE+ +C +G+ C C GF C +D
Sbjct: 1752 RPGFVIDIYTGLPVDIDECREIPGVCENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDE 1811
Query: 786 HQLLAGGEVDLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVG--CSMY 843
Q G V +N T S + + + +D+++C + CS +
Sbjct: 1812 CQ---NGPVCQRNAEC-----INTAGSYRCDCKPGYRFTSTGQCNDRNECQEIPNICS-H 1862
Query: 844 ARCISEGEDATCQCLKGFA--GDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSE 901
+CI C C GF D +C DI+ECE C + C NT G + CRC+
Sbjct: 1863 GQCIDTVGSFYCLCHTGFKTNDDQTMCLDINECERDA--C--GNGTCRNTIGSFNCRCNH 1918
Query: 902 GY-QGDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHL 960
G+ C+D+DEC G + N C NT G + C C +E + PD +
Sbjct: 1919 GFILSHNNDCIDVDECASGNGNLCRNGQCINTVGSFQCQC----NEGYEVAPDGRTCVDI 1974
Query: 961 REDDHHYSVRNSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYI--GERCQ 1013
+EC L C G C ++ Y C C GY E+C+
Sbjct: 1975 -------------NEC-LLEPRKCA-PGTCQNLDG--SYRCICPPGYSLQNEKCE 2012
Score = 74.7 bits (182), Expect = 5e-13
Identities = 47/162 (29%), Positives = 67/162 (41%), Gaps = 16/162 (9%)
Query: 325 CSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPV 384
C + C + C C EG+ CED+NECA C C NT GSY C CPV
Sbjct: 2176 CGNGTCKNVIGGFECTCEEGFEPG-PMMTCEDINECAQNPLLCAFRCVNTYGSYECKCPV 2234
Query: 385 GFVLLPDGKRCHQLVSCPRNVSECSH---DCVLTSEGPLCFCPEGSVLERDGKTC---SG 438
G+VL D + C C +C+ +C +C C G DG+ C +
Sbjct: 2235 GYVLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCVDENE 2294
Query: 439 CSSP----DNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
C + +NG C + S+ C+C G+ ++ C
Sbjct: 2295 CQTKPGICENGRCLN-----TRGSYTCECNDGFTASPNQDEC 2331
Score = 73.6 bits (179), Expect = 1e-12
Identities = 62/206 (30%), Positives = 81/206 (39%), Gaps = 49/206 (23%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLG-CKNTPG 376
C L C+ C S+ C+C GY+L ++ CED++EC C LG C NT G
Sbjct: 1977 CLLEPRKCAPGTCQNLDGSYRCICPPGYSLQNEK--CEDIDECVEEPEICALGTCSNTEG 2034
Query: 377 SYYCTCPVGFVLLPDGKRCHQL-------------VSCP--RNVSECSHDCVLTSEG--- 418
S+ C CP GF L G+RC L S P RN S+ C L EG
Sbjct: 2035 SFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGEGWGD 2094
Query: 419 --PLC----------FCPEGSVL----ERDGKTCSGCSSPD---NGGCSQLCVPLSPVSW 459
LC CP GS + + C PD +G C + S+
Sbjct: 2095 PCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDECKEPDVCKHGQCIN-----TDGSY 2149
Query: 460 ECDCFPGYDLQ----LDEKSCAASGP 481
C+C GY L +D C+ P
Sbjct: 2150 RCECPFGYILAGNECVDTDECSVGNP 2175
Score = 73.6 bits (179), Expect = 1e-12
Identities = 59/234 (25%), Positives = 83/234 (35%), Gaps = 59/234 (25%)
Query: 752 CEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLDILSKTRV 811
C ICK G+ CSC +G++ DG++C LD + + L +
Sbjct: 2455 CNFICKNTEGSYQCSCPKGYILQEDGRSCKDLD----------ECATKQHNCQFLCVNTI 2504
Query: 812 SEDNITESQHMLVAEIMVSDQDDCAPVG--CSMYARCISEGEDATCQCLKGFAGD--GKL 867
D ++C C C + TC+C +GF+ D G
Sbjct: 2505 GGFTCKCPPGFTQHHTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSS 2564
Query: 868 CSDIDECE---------------------------------------MGVPVCPPASSKC 888
C D+DECE + +C AS C
Sbjct: 2565 CEDVDECEGNHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQCVDENECLSAHICGGAS--C 2622
Query: 889 INTEGGYVCRCSEGYQGDGIH--CLDIDECQLGEHSCGENASCTNTEGGYTCMC 940
NT G Y C C G+Q + C DI+EC + C + C+NTEGGY C C
Sbjct: 2623 HNTLGSYKCMCPAGFQYEQFSGGCQDINECGSAQAPC--SYGCSNTEGGYLCGC 2674
Score = 73.2 bits (178), Expect = 1e-12
Identities = 53/161 (32%), Positives = 73/161 (45%), Gaps = 28/161 (17%)
Query: 330 CGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLG-CKNTPGSYYCTCPVGFVL 388
C + S+ C+C EGY + D C D++EC+ + C G C N PG Y C C +GFV
Sbjct: 1380 CKNTMGSYRCLCKEGY--TGDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVP 1437
Query: 389 LPDGKRCHQLVSCPRNVSECS--HDCVLTSEGPL-----CFCPEGSVLERDGKTCSG--- 438
DGK C ++ ECS + CV + L C C G L+R G C+
Sbjct: 1438 SADGKACE-------DIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNE 1490
Query: 439 CSSPD---NGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
C P +G C +P S+ CDC P ++L C
Sbjct: 1491 CLDPTTCISGNCVN-----TPGSYICDCPPDFELNPTRVGC 1526
Score = 73.2 bits (178), Expect = 1e-12
Identities = 38/111 (34%), Positives = 51/111 (45%), Gaps = 6/111 (5%)
Query: 831 DQDDCAPVGCSMYARCISEGEDATCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCIN 890
D D+C + +CI+ C+C G+ G C D DEC +G P + C N
Sbjct: 2127 DMDECKEPDVCKHGQCINTDGSYRCECPFGYILAGNECVDTDECSVGNPC---GNGTCKN 2183
Query: 891 TEGGYVCRCSEGYQ-GDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMC 940
GG+ C C EG++ G + C DI+EC C C NT G Y C C
Sbjct: 2184 VIGGFECTCEEGFEPGPMMTCEDINECAQNPLLCA--FRCVNTYGSYECKC 2232
Score = 72.8 bits (177), Expect = 2e-12
Identities = 57/190 (30%), Positives = 81/190 (42%), Gaps = 16/190 (8%)
Query: 291 PLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRD 350
P G +V P D+ EP+ +CK G C +T S+ C C GY L+ +
Sbjct: 2112 PYGSGIIVGPDDSAVDMDECKEPD--VCK--HGQCINTD-----GSYRCECPFGYILAGN 2162
Query: 351 RKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSH 410
C D +EC+ N CKN G + CTC GF P C + C +N C+
Sbjct: 2163 E--CVDTDECSVGNPCGNGTCKNVIGGFECTCEEGFEPGP-MMTCEDINECAQNPLLCAF 2219
Query: 411 DCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDNG--GCSQLCVPLSPV--SWECDCFPG 466
CV T C CP G VL D + C + G C++ + + ++ C C PG
Sbjct: 2220 RCVNTYGSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTYMCICGPG 2279
Query: 467 YDLQLDEKSC 476
Y + D + C
Sbjct: 2280 YQRRPDGEGC 2289
Score = 70.5 bits (171), Expect = 9e-12
Identities = 50/152 (32%), Positives = 67/152 (44%), Gaps = 10/152 (6%)
Query: 325 CSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLG-CKNTPGSYYCTCP 383
CS C + S C+C G+ + D+ C D+NEC C G C+NT GS+ C C
Sbjct: 1860 CSHGQCIDTVGSFYCLCHTGFKTNDDQTMCLDINECE--RDACGNGTCRNTIGSFNCRCN 1917
Query: 384 VGFVLLPDGKRCHQLVSCPR-NVSECSH-DCVLTSEGPLCFCPEGSVLERDGKTC---SG 438
GF+ L C + C N + C + C+ T C C EG + DG+TC +
Sbjct: 1918 HGFI-LSHNNDCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINE 1976
Query: 439 CSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQ 470
C C L S+ C C PGY LQ
Sbjct: 1977 CLLEPRKCAPGTCQNLDG-SYRCICPPGYSLQ 2007
Score = 70.1 bits (170), Expect = 1e-11
Identities = 68/241 (28%), Positives = 88/241 (36%), Gaps = 63/241 (26%)
Query: 756 CKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLDILSKTRVSEDN 815
CK +GT C C G+ + DG+ C+ + Q G +N S T D
Sbjct: 2265 CKNLIGTYMCICGPGYQRRPDGEGCVDENECQTKPG---ICENGRCLNTRGSYTCECNDG 2321
Query: 816 ITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQ--------------CLKGF 861
T S + QD+C + C +E CQ C G
Sbjct: 2322 FTASPN----------QDECLD---NREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGG 2368
Query: 862 AGDG---------------KLC----------SDIDECEMGVPVCPPASSKCINTEGGYV 896
G G KLC +DIDEC++ VC + +C+N G Y
Sbjct: 2369 RGWGPHCEICPFQGTVAFKKLCPHGRGFMTNGADIDECKVIHDVC--RNGECVNDRGSYH 2426
Query: 897 CRCSEGYQGD--GIHCLDIDECQLGEHSCGENASCTNTEGGYTCMCAGR--LSEPGLICP 952
C C GY D G C+D++EC C N C NTEG Y C C L E G C
Sbjct: 2427 CICKTGYTPDITGTSCVDLNECNQAPKPC--NFICKNTEGSYQCSCPKGYILQEDGRSCK 2484
Query: 953 D 953
D
Sbjct: 2485 D 2485
Score = 69.3 bits (168), Expect = 2e-11
Identities = 66/241 (27%), Positives = 94/241 (39%), Gaps = 37/241 (15%)
Query: 743 DPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTC----------LALDGH------ 786
D C +N +C G+ C C+ GF ASDG+ C + ++G
Sbjct: 574 DECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINECETPGICMNGRCVNTDG 633
Query: 787 ----QLLAGGEVDLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSM 842
+ G V L +V + T + L + S+ CA +
Sbjct: 634 SYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFGAVTKSECC-CASTEYAF 692
Query: 843 YARCI------SEGEDATCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYV 896
C S A C G G SDI+EC + +CP + C N G Y
Sbjct: 693 GEPCQPCPAQNSAEYQALCSSGPGMTSAG---SDINECALDPDICP--NGICENLRGTYK 747
Query: 897 CRCSEGYQGD--GIHCLDIDECQLGEHSCGENASCTNTEGGYTCMC-AGRLSEPGL-ICP 952
C C+ GY+ D G +C+DI+EC L C +N C NT G + C C G + +P L C
Sbjct: 748 CICNSGYEVDSTGKNCVDINECVLNSLLC-DNGQCRNTPGSFVCTCPKGFIYKPDLKTCE 806
Query: 953 D 953
D
Sbjct: 807 D 807
Score = 68.6 bits (166), Expect = 4e-11
Identities = 50/192 (26%), Positives = 69/192 (35%), Gaps = 47/192 (24%)
Query: 329 VCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGC------TLG------------ 370
+C S+ C C +GY L D + C+D++ECA H C T+G
Sbjct: 2458 ICKNTEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPGFTQ 2517
Query: 371 -----------------------CKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSE 407
C+NTPGS+ C C GF L G C + C N
Sbjct: 2518 HHTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDECEGN-HR 2576
Query: 408 CSHDCVLTSEGPLCFCPEGSVLERDGKTC---SGCSSPDNGGCSQLCVPLSPVSWECDCF 464
C H C G C CP+G + C + C S G + L S++C C
Sbjct: 2577 CQHGCQNIIGGYRCSCPQGYLQHYQWNQCVDENECLSAHICGGASCHNTLG--SYKCMCP 2634
Query: 465 PGYDLQLDEKSC 476
G+ + C
Sbjct: 2635 AGFQYEQFSGGC 2646
Score = 67.8 bits (164), Expect = 6e-11
Identities = 70/257 (27%), Positives = 100/257 (38%), Gaps = 52/257 (20%)
Query: 756 CKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLDILSKTRVSEDN 815
C G+ C C EGF +S G+ C L A K + +
Sbjct: 2029 CSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYA-----------------KFEGGKCS 2071
Query: 816 ITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQ-CLKG---FAGDGKLCSDI 871
+S++ E + + + C + C +E ++A Q C G G D+
Sbjct: 2072 SPKSRNHSKQECCCALKGEGWGDPCEL---CPTEPDEAFRQICPYGSGIIVGPDDSAVDM 2128
Query: 872 DECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCLDIDECQLGEHSCGENASCTN 931
DEC+ VC +CINT+G Y C C GY G C+D DEC +G + CG N +C N
Sbjct: 2129 DECKEP-DVCK--HGQCINTDGSYRCECPFGYILAGNECVDTDECSVG-NPCG-NGTCKN 2183
Query: 932 TEGGYTCMCAGRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCLHDGVCM 991
GG+ C C E G P P + +D + +N PL C
Sbjct: 2184 VIGGFECTC-----EEGF-----EPGPMMTCEDINECAQN-----PLLCAFRC------- 2221
Query: 992 YIEALDKYACNCVVGYI 1008
+ Y C C VGY+
Sbjct: 2222 -VNTYGSYECKCPVGYV 2237
Score = 67.4 bits (163), Expect = 8e-11
Identities = 41/131 (31%), Positives = 55/131 (41%), Gaps = 5/131 (3%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLG-CKNTPG 376
C C + C + C C G+ S D K CED++EC+ N C G C N PG
Sbjct: 1408 CSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNI-CVFGTCHNLPG 1466
Query: 377 SYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTC 436
+ C C +G+ L G C + C + S +CV T +C CP L T
Sbjct: 1467 LFRCECEIGYELDRSGGNCTDVNECLDPTTCISGNCVNTPGSYICDCPPDFEL---NPTR 1523
Query: 437 SGCSSPDNGGC 447
GC +G C
Sbjct: 1524 VGCVDTRSGNC 1534
Score = 67.4 bits (163), Expect = 8e-11
Identities = 45/147 (30%), Positives = 54/147 (36%), Gaps = 12/147 (8%)
Query: 330 CGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLL 389
C + + C C +GY C D NEC + C NT GSY C CP GF
Sbjct: 2581 CQNIIGGYRCSCPQGYLQHYQWNQCVDENECLSAHICGGASCHNTLGSYKCMCPAGFQYE 2640
Query: 390 PDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDNGGCSQ 449
C + C + CS+ C T G LC CP G G SG
Sbjct: 2641 QFSGGCQDINECGSAQAPCSYGCSNTEGGYLCGCPPGYFRIGQGHCVSGMGMGRGN---- 2696
Query: 450 LCVPLSPVSWECDCFPGYDLQLDEKSC 476
P PVS E D D L ++C
Sbjct: 2697 ---PEPPVSGEMD-----DNSLSPEAC 2715
Score = 67.0 bits (162), Expect = 1e-10
Identities = 44/162 (27%), Positives = 63/162 (38%), Gaps = 8/162 (4%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGS 377
C+ G C C S C C GY L+ D + C+DVNEC C NT G+
Sbjct: 1610 CQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNECETPGICGPGTCYNTVGN 1669
Query: 378 YYCTCPVGFVLLPDGKRCHQL--VSCPRNV----SECSHDCVLTSEGPLCFCPEGSVLER 431
Y C CP ++ + G C + C RN C + + +C C ++
Sbjct: 1670 YTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELLFNMTKKMCCC-SYNIGRA 1728
Query: 432 DGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDE 473
K C C P + LC P + D + G + +DE
Sbjct: 1729 WNKPCEQCPIPSTDEFATLCGSQRP-GFVIDIYTGLPVDIDE 1769
Score = 67.0 bits (162), Expect = 1e-10
Identities = 60/219 (27%), Positives = 87/219 (39%), Gaps = 39/219 (17%)
Query: 756 CKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLDIL----SKTRV 811
C +G C C +M+ + G C +D + L NQ ++L K
Sbjct: 1663 CYNTVGNYTCICPPDYMQVNGGNNC--MDMRRSLCYRNYYADNQTCDGELLFNMTKKMCC 1720
Query: 812 SEDNITESQHM-----------------------LVAEIMVS---DQDDCAPV-GCSMYA 844
NI + + V +I D D+C + G
Sbjct: 1721 CSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDECREIPGVCENG 1780
Query: 845 RCISEGEDATCQCLKGFAGDGKL--CSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEG 902
CI+ C+C GF + KL C DIDEC+ G PVC +++CINT G Y C C G
Sbjct: 1781 VCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNG-PVC-QRNAECINTAGSYRCDCKPG 1838
Query: 903 YQGDGI-HCLDIDECQLGEHSCGENASCTNTEGGYTCMC 940
Y+ C D +ECQ + C + C +T G + C+C
Sbjct: 1839 YRFTSTGQCNDRNECQEIPNIC-SHGQCIDTVGSFYCLC 1876
Score = 66.6 bits (161), Expect = 1e-10
Identities = 44/167 (26%), Positives = 65/167 (38%), Gaps = 24/167 (14%)
Query: 321 RKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYC----------------------EDVN 358
++G C + G +S C + YA + C D+N
Sbjct: 666 KRGQCIKPLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGSDIN 725
Query: 359 ECAFWNHGCTLG-CKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSH-DCVLTS 416
ECA C G C+N G+Y C C G+ + GK C + C N C + C T
Sbjct: 726 ECALDPDICPNGICENLRGTYKCICNSGYEVDSTGKNCVDINECVLNSLLCDNGQCRNTP 785
Query: 417 EGPLCFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDC 463
+C CP+G + + D KTC ++ C SP S+ C+C
Sbjct: 786 GSFVCTCPKGFIYKPDLKTCEDIDECESSPCINGVCKNSPGSFICEC 832
Score = 63.9 bits (154), Expect = 9e-10
Identities = 31/79 (39%), Positives = 40/79 (50%), Gaps = 1/79 (1%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLG-CKNTPG 376
C+ G C C + S C C G+ L+ + CED++EC+ C G C NT
Sbjct: 250 CQAIPGLCQGGNCINTVGSFECKCPAGHKLNEVSQKCEDIDECSTIPGICEGGECTNTVS 309
Query: 377 SYYCTCPVGFVLLPDGKRC 395
SY+C CP GF PDG RC
Sbjct: 310 SYFCKCPPGFYTSPDGTRC 328
Score = 62.0 bits (149), Expect = 3e-09
Identities = 70/269 (26%), Positives = 101/269 (37%), Gaps = 35/269 (13%)
Query: 756 CKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLDILSKTRVSEDN 815
C G+ C CR G+ C +D + L G + + D +
Sbjct: 504 CINNQGSYTCQCRAGYQSTLTRTECRDID--ECLQNGRICNNGRCINTDGSFHCVCNA-- 559
Query: 816 ITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQCLKGF--AGDGKLCSDIDE 873
H+ D D+C+ + CI+E C C GF A DG+ C DI+E
Sbjct: 560 ---GFHVTRDGKNCEDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINE 616
Query: 874 CEMGVPVCPPASSKCINTEGGYVCRCSEGYQG--DGIHCLD--IDECQLGEHSCGE---- 925
CE +C + +C+NT+G Y C C G DG C+D + G + G+
Sbjct: 617 CETP-GIC--MNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKP 673
Query: 926 -NASCTNTEGGYTCMCAG---RLSEPGLICP--DSTPPPHLREDDHHYSVRNSD-SECPL 978
+ T +E C CA EP CP +S L + SD +EC L
Sbjct: 674 LFGAVTKSE----CCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGSDINECAL 729
Query: 979 SHDGYCLHDGVCMYIEALDKYACNCVVGY 1007
D +G+C + Y C C GY
Sbjct: 730 DPD--ICPNGICENLRG--TYKCICNSGY 754
Score = 62.0 bits (149), Expect = 3e-09
Identities = 36/91 (39%), Positives = 48/91 (52%), Gaps = 9/91 (9%)
Query: 855 CQCLKGFAGD--GKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEG--YQGDGIHC 910
C C G+ D GK C DI+EC + +C + +C NT G +VC C +G Y+ D C
Sbjct: 748 CICNSGYEVDSTGKNCVDINECVLNSLLCD--NGQCRNTPGSFVCTCPKGFIYKPDLKTC 805
Query: 911 LDIDECQLGEHSCGENASCTNTEGGYTCMCA 941
DIDEC E S N C N+ G + C C+
Sbjct: 806 EDIDEC---ESSPCINGVCKNSPGSFICECS 833
Score = 62.0 bits (149), Expect = 3e-09
Identities = 25/68 (36%), Positives = 33/68 (48%)
Query: 325 CSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPV 384
C C L S+ CMC G+ + C+D+NEC C+ GC NT G Y C CP
Sbjct: 2617 CGGASCHNTLGSYKCMCPAGFQYEQFSGGCQDINECGSAQAPCSYGCSNTEGGYLCGCPP 2676
Query: 385 GFVLLPDG 392
G+ + G
Sbjct: 2677 GYFRIGQG 2684
Score = 61.6 bits (148), Expect = 4e-09
Identities = 47/171 (27%), Positives = 67/171 (39%), Gaps = 14/171 (8%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHG--C--TLGCKN 373
C+ G C + VC + S C C G+ + CED++EC +G C C N
Sbjct: 1770 CREIPGVCENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDEC---QNGPVCQRNAECIN 1826
Query: 374 TPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSH-DCVLTSEGPLCFCPEGSVLERD 432
T GSY C C G+ G +C+ C + CSH C+ T C C G D
Sbjct: 1827 TAGSYRCDCKPGYRFTSTG-QCNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNDD 1885
Query: 433 GKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQ-----LDEKSCAA 478
C + + C + S+ C C G+ L +D CA+
Sbjct: 1886 QTMCLDINECERDACGNGTCRNTIGSFNCRCNHGFILSHNNDCIDVDECAS 1936
Score = 60.8 bits (146), Expect = 7e-09
Identities = 38/106 (35%), Positives = 51/106 (48%), Gaps = 9/106 (8%)
Query: 857 CLKGFAGDGKL--CSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGI--HCLD 912
C +GF + + C D+DEC+ +C CINT G + C+C G++ + + C D
Sbjct: 231 CRRGFIPNIRTGACQDVDECQAIPGLCQ--GGNCINTVGSFECKCPAGHKLNEVSQKCED 288
Query: 913 IDECQLGEHSCGENASCTNTEGGYTCMC-AGRLSEP-GLICPDSTP 956
IDEC C E CTNT Y C C G + P G C D P
Sbjct: 289 IDECSTIPGIC-EGGECTNTVSSYFCKCPPGFYTSPDGTRCIDVRP 333
Score = 60.8 bits (146), Expect = 7e-09
Identities = 42/151 (27%), Positives = 64/151 (42%), Gaps = 7/151 (4%)
Query: 330 CGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLG-CKNTPGSYYCTCPVGFVL 388
C S+ C C GY + + C D NEC + C+ G C +T GS+YC C GF
Sbjct: 1824 CINTAGSYRCDCKPGYRFTSTGQ-CNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKT 1882
Query: 389 LPDGKRCHQLVSCPRNVSECSHDCVLTSEGPL-CFCPEGSVLERDGKTCS--GCSSPDNG 445
D C + C R+ C + + G C C G +L + C+S +
Sbjct: 1883 NDDQTMCLDINECERDA--CGNGTCRNTIGSFNCRCNHGFILSHNNDCIDVDECASGNGN 1940
Query: 446 GCSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
C + S++C C GY++ D ++C
Sbjct: 1941 LCRNGQCINTVGSFQCQCNEGYEVAPDGRTC 1971
Score = 57.8 bits (138), Expect = 6e-08
Identities = 40/134 (29%), Positives = 53/134 (39%), Gaps = 9/134 (6%)
Query: 341 CAEGYALSRDRKYCEDVNECAFWNHGCTLG-CKNTPGSYYCTCPVGFVLLPDGKRCHQLV 399
C G+ + C+DV+EC C G C NT GS+ C CP G L ++C +
Sbjct: 231 CRRGFIPNIRTGACQDVDECQAIPGLCQGGNCINTVGSFECKCPAGHKLNEVSQKCEDID 290
Query: 400 SCPRNVSEC-SHDCVLTSEGPLCFCPEGSVLERDGKTCSGC------SSPDNGGCSQLCV 452
C C +C T C CP G DG C ++ NG CS +
Sbjct: 291 ECSTIPGICEGGECTNTVSSYFCKCPPGFYTSPDGTRCIDVRPGYCYTALTNGRCSNQ-L 349
Query: 453 PLSPVSWECDCFPG 466
P S +C C G
Sbjct: 350 PQSITKMQCCCDAG 363
Score = 57.8 bits (138), Expect = 6e-08
Identities = 32/76 (42%), Positives = 41/76 (53%), Gaps = 6/76 (7%)
Query: 867 LCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGY--QGDGIHCLDIDECQLGEHSCG 924
+ DIDEC+ +C KCINT G + CRC GY D C D++EC+ CG
Sbjct: 1603 ILEDIDECQELPGLCQ--GGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNECET-PGICG 1659
Query: 925 ENASCTNTEGGYTCMC 940
+C NT G YTC+C
Sbjct: 1660 P-GTCYNTVGNYTCIC 1674
Score = 53.9 bits (128), Expect = 9e-07
Identities = 50/178 (28%), Positives = 80/178 (44%), Gaps = 25/178 (14%)
Query: 756 CKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLDILSKTRVSEDN 815
C+ G+ C+C +GF+ D KTC +D + KN +P + + SE
Sbjct: 781 CRNTPGSFVCTCPKGFIYKPDLKTCEDIDECESSPCINGVCKN--SPGSFICECS-SEST 837
Query: 816 ITESQHMLVAEI-------MVSDQDDCAPVGCSMYARCISE-----GEDAT-CQ----CL 858
+ ++ + + I ++ + + G ++ ++C S G T CQ C
Sbjct: 838 LDPTKTICIETIKGTCWQTVIDGRCEININGATLKSQCCSSLGAAWGSPCTLCQVDPICG 897
Query: 859 KGFAG-DGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGD--GIHCLDI 913
KG++ G C DIDECE+ VC + C+NT G + C+C G D G CLDI
Sbjct: 898 KGYSRIKGTQCEDIDECEVFPGVCK--NGLCVNTRGSFKCQCPSGMTLDATGRICLDI 953
Score = 52.4 bits (124), Expect = 3e-06
Identities = 26/70 (37%), Positives = 39/70 (55%), Gaps = 6/70 (8%)
Query: 872 DECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGD-GIHCLDIDECQLGEHSCGENASCT 930
D C++ +C + +CI T G C C++G+Q D C+D+DEC+ + GE C
Sbjct: 451 DYCQLVRYLCQ--NGRCIPTPGSCRCECNKGFQLDLRGECIDVDECEKNPCAGGE---CI 505
Query: 931 NTEGGYTCMC 940
N +G YTC C
Sbjct: 506 NNQGSYTCQC 515
Score = 52.4 bits (124), Expect = 3e-06
Identities = 64/270 (23%), Positives = 98/270 (36%), Gaps = 30/270 (11%)
Query: 743 DPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDG---HQLLAGGEVDLKNQ 799
DP + NG CE++ GT C C G+ S GK C+ ++ + LL
Sbjct: 730 DPDICPNGICENL----RGTYKCICNSGYEVDSTGKNCVDINECVLNSLLCDNGQCRNTP 785
Query: 800 VTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEG--EDATCQC 857
+ + K + + ++ + + E C S C SE + C
Sbjct: 786 GSFVCTCPKGFIYKPDLKTCEDIDECESSPCINGVCKNSPGSFICECSSESTLDPTKTIC 845
Query: 858 LKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGY-----VCR----CSEGYQG-DG 907
++ G CE+ + S C + + +C+ C +GY G
Sbjct: 846 IETIKGTCWQTVIDGRCEININGATLKSQCCSSLGAAWGSPCTLCQVDPICGKGYSRIKG 905
Query: 908 IHCLDIDECQLGEHSCGENASCTNTEGGYTCMCAG--RLSEPGLICPDSTPPPHLREDDH 965
C DIDEC++ C +N C NT G + C C L G IC D +R +
Sbjct: 906 TQCEDIDECEVFPGVC-KNGLCVNTRGSFKCQCPSGMTLDATGRICLD------IRLET- 957
Query: 966 HYSVRNSDSECPLSHDGYCLHDGVCMYIEA 995
+R D EC L G D C + A
Sbjct: 958 -CFLRYEDEECTLPIAGRHRMDACCCSVGA 986
Score = 51.6 bits (122), Expect = 4e-06
Identities = 30/108 (27%), Positives = 51/108 (47%), Gaps = 8/108 (7%)
Query: 827 IMVSDQDDCAPV-GCSMYARCISEGEDATCQCLKGFA--GDGKLCSDIDECEMGVPVCPP 883
+++ D D+C + G +CI+ C+C G+ D ++C D++ECE +C P
Sbjct: 1602 VILEDIDECQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNECETP-GICGP 1660
Query: 884 ASSKCINTEGGYVCRCSEGYQ--GDGIHCLDIDECQLGEHSCGENASC 929
+ C NT G Y C C Y G +C+D+ + +N +C
Sbjct: 1661 GT--CYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTC 1706
Score = 51.2 bits (121), Expect = 6e-06
Identities = 74/293 (25%), Positives = 105/293 (35%), Gaps = 55/293 (18%)
Query: 743 DPCLYQNGGCEHICKKRLGTAWCSCREGF-----MKASDGKTCLALDGHQLLAG------ 791
D C N CK +G C+C EGF M D C + LL
Sbjct: 2168 DECSVGNPCGNGTCKNVIGGFECTCEEGFEPGPMMTCEDINECAQ---NPLLCAFRCVNT 2224
Query: 792 -GEVDLKNQVTPLDILSKTR---VSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCI 847
G + K V +L + R ED E +H DC C
Sbjct: 2225 YGSYECKCPVGY--VLREDRRMCKDEDECEEGKH------------DCT----EKQMECK 2266
Query: 848 SEGEDATCQCLKGFAG--DGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQG 905
+ C C G+ DG+ C D +EC+ +C + +C+NT G Y C C++G+
Sbjct: 2267 NLIGTYMCICGPGYQRRPDGEGCVDENECQTKPGICE--NGRCLNTRGSYTCECNDGFTA 2324
Query: 906 --DGIHCLDIDE----CQLGEHSCGENASCTNTEGGYTCMC-AGRLSEPGL-ICP--DST 955
+ CLD E ++ ++ C +S N C C GR P ICP +
Sbjct: 2325 SPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPFQGTV 2384
Query: 956 PPPHLREDDHHYSVRNSD-SECPLSHDGYCLHDGVCMYIEALDKYACNCVVGY 1007
L + +D EC + HD +G C + Y C C GY
Sbjct: 2385 AFKKLCPHGRGFMTNGADIDECKVIHD--VCRNGEC--VNDRGSYHCICKTGY 2433
Score = 51.2 bits (121), Expect = 6e-06
Identities = 48/169 (28%), Positives = 68/169 (40%), Gaps = 25/169 (14%)
Query: 751 GCEHICKKRLGTAWCSCREGFMKASDGKTCLALD----GHQLLAGGEVDLKNQVTPLDIL 806
G + IC+ G+ C C+ GF G +C +D H+ G + +I+
Sbjct: 2536 GSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDECEGNHRCQHGCQ----------NII 2585
Query: 807 SKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQCLKGFAGD-- 864
R S QH + + D+++C A C + C C GF +
Sbjct: 2586 GGYRCSCPQ-GYLQHYQWNQCV--DENECLSAHICGGASCHNTLGSYKCMCPAGFQYEQF 2642
Query: 865 GKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGY--QGDGIHCL 911
C DI+EC C S C NTEGGY+C C GY G G HC+
Sbjct: 2643 SGGCQDINECGSAQAPC---SYGCSNTEGGYLCGCPPGYFRIGQG-HCV 2687
Score = 49.7 bits (117), Expect = 2e-05
Identities = 46/181 (25%), Positives = 71/181 (39%), Gaps = 40/181 (22%)
Query: 306 AEDDTWEPEQKLC-KLRKGNCSSTVC---------GQDLQSHLC---------------- 339
+ + T +P + +C + KG C TV G L+S C
Sbjct: 833 SSESTLDPTKTICIETIKGTCWQTVIDGRCEININGATLKSQCCSSLGAAWGSPCTLCQV 892
Query: 340 --MCAEGYALSRDRKYCEDVNECAFWNHGCTLG-CKNTPGSYYCTCPVGFVLLPDGKRC- 395
+C +GY+ + + CED++EC + C G C NT GS+ C CP G L G+ C
Sbjct: 893 DPICGKGYSRIKGTQ-CEDIDECEVFPGVCKNGLCVNTRGSFKCQCPSGMTLDATGRICL 951
Query: 396 -HQLVSCPRNVSECSHDCVLTSEG----PLCFCPEGSVLERDGKTCSGCSSPDNGGCSQL 450
+L +C + +C L G C C G+ + C C + +L
Sbjct: 952 DIRLETCFLRYED--EECTLPIAGRHRMDACCCSVGAAWGTE--ECEECPMRNTPEYEEL 1007
Query: 451 C 451
C
Sbjct: 1008 C 1008
Score = 42.4 bits (98), Expect = 0.003
Identities = 47/198 (23%), Positives = 72/198 (36%), Gaps = 40/198 (20%)
Query: 314 EQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNE----CAFWNHGCTL 369
++ C+ + G C + C S+ C C +G+ S ++ C D E + C +
Sbjct: 2291 DENECQTKPGICENGRCLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMCQI 2350
Query: 370 GC--KNTPGSYYCTCPVGFVLLPDGKRCHQLVS------CPR---------NVSECS--H 410
G +N C C G P + C + CP ++ EC H
Sbjct: 2351 GSSNRNPVTKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNGADIDECKVIH 2410
Query: 411 D------CVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPV------S 458
D CV C C G + G +C D C+Q P + + S
Sbjct: 2411 DVCRNGECVNDRGSYHCICKTGYTPDITGTSC-----VDLNECNQAPKPCNFICKNTEGS 2465
Query: 459 WECDCFPGYDLQLDEKSC 476
++C C GY LQ D +SC
Sbjct: 2466 YQCSCPKGYILQEDGRSC 2483
Score = 38.9 bits (89), Expect = 0.030
Identities = 38/160 (23%), Positives = 55/160 (34%), Gaps = 44/160 (27%)
Query: 360 CAFWNHGCTLG-CKNTPGSYYCTCPVGFVLLPDGK------------------------- 393
C + C G C TPGS C C GF L G+
Sbjct: 453 CQLVRYLCQNGRCIPTPGSCRCECNKGFQLDLRGECIDVDECEKNPCAGGECINNQGSYT 512
Query: 394 --------------RCHQLVSCPRNVSECSHDCVLTSEGPL-CFCPEGSVLERDGKTCSG 438
C + C +N C++ + ++G C C G + RDGK C
Sbjct: 513 CQCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVTRDGKNCED 572
Query: 439 CS--SPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
S N + +C+ S++C C PG+ L D + C
Sbjct: 573 MDECSIRNMCLNGMCIN-EDGSFKCICKPGFQLASDGRYC 611
Score = 32.0 bits (71), Expect = 3.7
Identities = 19/72 (26%), Positives = 24/72 (33%), Gaps = 4/72 (5%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNE----CAFWNHGCTLGCKN 373
C G C C + S+ C C G+ S D C DV A N C+
Sbjct: 292 CSTIPGICEGGECTNTVSSYFCKCPPGFYTSPDGTRCIDVRPGYCYTALTNGRCSNQLPQ 351
Query: 374 TPGSYYCTCPVG 385
+ C C G
Sbjct: 352 SITKMQCCCDAG 363
>gi|11321565 matrilin 3 precursor [Homo sapiens]
Length = 486
Score = 115 bits (289), Expect = 2e-25
Identities = 62/167 (37%), Positives = 79/167 (47%), Gaps = 6/167 (3%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKN-TPG 376
C L C H C C++GY L+ D+K C ++ CA HGC C N G
Sbjct: 268 CVLGTHQCQHVCISDGEGKHHCECSQGYTLNADKKTCSALDRCALNTHGCEHICVNDRSG 327
Query: 377 SYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGP-LCFCPEGSVLERDGKT 435
SY+C C G+ L D K C C C H CV G C C EG L D KT
Sbjct: 328 SYHCECYEGYTLNEDRKTCSAQDKCALGTHGCQHICVNDRTGSHHCECYEGYTLNADKKT 387
Query: 436 CS---GCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAAS 479
CS C+ + GC +CV S+ CDC+PGY L D+K+C+A+
Sbjct: 388 CSVRDKCALGSH-GCQHICVSDGAASYHCDCYPGYTLNEDKKTCSAT 433
Score = 80.1 bits (196), Expect = 1e-14
Identities = 50/141 (35%), Positives = 59/141 (41%), Gaps = 13/141 (9%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKN-TPG 376
C L C S+ C C EGY L+ DRK C ++CA HGC C N G
Sbjct: 310 CALNTHGCEHICVNDRSGSYHCECYEGYTLNEDRKTCSAQDKCALGTHGCQHICVNDRTG 369
Query: 377 SYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPL---CFCPEGSVLERDG 433
S++C C G+ L D K C C C H CV S+G C C G L D
Sbjct: 370 SHHCECYEGYTLNADKKTCSVRDKCALGSHGCQHICV--SDGAASYHCDCYPGYTLNEDK 427
Query: 434 KTCSG-------CSSPDNGGC 447
KTCS S+ D GC
Sbjct: 428 KTCSATEEARRLVSTEDACGC 448
Score = 61.6 bits (148), Expect = 4e-09
Identities = 51/168 (30%), Positives = 70/168 (41%), Gaps = 31/168 (18%)
Query: 846 CISEGEDAT-CQCLKGFA--GDGKLCSDIDECEMGVPVCPPASSKCINTEGG-YVCRCSE 901
CIS+GE C+C +G+ D K CS +D C + C C+N G Y C C E
Sbjct: 279 CISDGEGKHHCECSQGYTLNADKKTCSALDRCALNTHGCEHI---CVNDRSGSYHCECYE 335
Query: 902 GY--QGDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPH 959
GY D C D+C LG H C ++ + G + C C +
Sbjct: 336 GYTLNEDRKTCSAQDKCALGTHGC-QHICVNDRTGSHHCECYEGYT-------------- 380
Query: 960 LREDDHHYSVRNSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGY 1007
L D SVR+ +C L G C H +C+ + Y C+C GY
Sbjct: 381 LNADKKTCSVRD---KCALGSHG-CQH--ICV-SDGAASYHCDCYPGY 421
Score = 60.8 bits (146), Expect = 7e-09
Identities = 33/93 (35%), Positives = 41/93 (44%), Gaps = 1/93 (1%)
Query: 315 QKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGC-KN 373
Q C L C SH C C EGY L+ D+K C ++CA +HGC C +
Sbjct: 349 QDKCALGTHGCQHICVNDRTGSHHCECYEGYTLNADKKTCSVRDKCALGSHGCQHICVSD 408
Query: 374 TPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVS 406
SY+C C G+ L D K C R VS
Sbjct: 409 GAASYHCDCYPGYTLNEDKKTCSATEEARRLVS 441
Score = 60.5 bits (145), Expect = 1e-08
Identities = 52/204 (25%), Positives = 72/204 (35%), Gaps = 58/204 (28%)
Query: 743 DPCLYQNGGCEHIC-KKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVT 801
DPC+ C+H+C G C C +G+ +D KTC ALD L G
Sbjct: 266 DPCVLGTHQCQHVCISDGEGKHHCECSQGYTLNADKKTCSALDRCALNTHG--------- 316
Query: 802 PLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQCLKGF 861
I V+D+ C+C +G+
Sbjct: 317 ----------------------CEHICVNDRSG-----------------SYHCECYEGY 337
Query: 862 A--GDGKLCSDIDECEMGVPVCPPASSKCINTE-GGYVCRCSEGY--QGDGIHCLDIDEC 916
D K CS D+C +G C C+N G + C C EGY D C D+C
Sbjct: 338 TLNEDRKTCSAQDKCALGTHGC---QHICVNDRTGSHHCECYEGYTLNADKKTCSVRDKC 394
Query: 917 QLGEHSCGENASCTNTEGGYTCMC 940
LG H C ++ ++ Y C C
Sbjct: 395 ALGSHGC-QHICVSDGAASYHCDC 417
Score = 34.3 bits (77), Expect = 0.74
Identities = 17/52 (32%), Positives = 24/52 (46%), Gaps = 1/52 (1%)
Query: 743 DPCLYQNGGCEHICKKRLGTAW-CSCREGFMKASDGKTCLALDGHQLLAGGE 793
D C + GC+HIC ++ C C G+ D KTC A + + L E
Sbjct: 392 DKCALGSHGCQHICVSDGAASYHCDCYPGYTLNEDKKTCSATEEARRLVSTE 443
>gi|56237021 fibrillin 3 precursor [Homo sapiens]
Length = 2809
Score = 108 bits (271), Expect = 2e-23
Identities = 75/268 (27%), Positives = 105/268 (39%), Gaps = 38/268 (14%)
Query: 745 CLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLD 804
C QNGGC+ C G+ CSC +G+ DG+ C +D E + +V
Sbjct: 1159 CRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVD--------ECEENPRVCDQG 1210
Query: 805 ILSKTRVSEDNITESQHMLVAEIMVS---DQDDCAPVGCSMYARCISEGEDATCQCLKGF 861
+ + M ++ D+ D P C ++ C + C C G+
Sbjct: 1211 HCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHIC-LHGDCENTKGSFVCHCQLGY 1269
Query: 862 A--GDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCLDIDECQLG 919
CSD+DECE+G C +S C+N G + CRC G+ GDG C D+DEC
Sbjct: 1270 MVRKGATGCSDVDECEVGGHNCDSHAS-CLNIPGSFSCRCLPGWVGDGFECHDLDECVSQ 1328
Query: 920 EHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLS 979
EH C C N G Y C C + G C +D N D L
Sbjct: 1329 EHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFC-----------EDRDECAENVD----LC 1373
Query: 980 HDGYCLHDGVCMYIEALDKYACNCVVGY 1007
+G CL+ A Y C C +G+
Sbjct: 1374 DNGQCLN--------APGGYRCECEMGF 1393
Score = 94.4 bits (233), Expect = 6e-19
Identities = 52/168 (30%), Positives = 73/168 (43%), Gaps = 13/168 (7%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGS 377
C L G C C + + C C G+ + DR+ C D+NEC N GC + C NT GS
Sbjct: 1117 CSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGS 1176
Query: 378 YYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSH-DCVLTSEGPLCFCPEGSVLERDGKTC 436
Y C+C G+ L+PDG+ C + C N C C G C C +G + D +TC
Sbjct: 1177 YRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTC 1236
Query: 437 SGCSSPD-------NGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCA 477
D +G C + S+ C C GY ++ C+
Sbjct: 1237 VDVDECDLNPHICLHGDCEN-----TKGSFVCHCQLGYMVRKGATGCS 1279
Score = 91.3 bits (225), Expect = 5e-18
Identities = 78/292 (26%), Positives = 118/292 (40%), Gaps = 39/292 (13%)
Query: 745 CLYQNGGCEH-ICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPL 803
C G C H C+ +G+ C+C GF + + C +D ++ DL Q T +
Sbjct: 990 CKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRI----SPDLCGQGTCV 1045
Query: 804 DILSKTRVSEDNITESQHMLVAEIMVSDQDDCA--PVGCSMYARCISEGEDATCQCLKG- 860
+ ES ML+ M D D+CA P+ C C + CQC G
Sbjct: 1046 NTPGSFECECFPGYESGFMLMKNCM--DVDECARDPLLC-RGGTCTNTDGSYKCQCPPGH 1102
Query: 861 -FAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQG--DGIHCLDIDECQ 917
G C DIDEC + +CP +C+N G + C C G+Q D C+DI+EC+
Sbjct: 1103 ELTAKGTACEDIDECSLSDGLCP--HGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECR 1160
Query: 918 LGEHSCGENASCTNTEGGYTCMCAG--RLSEPGLICPD-STPPPHLREDDHHYSVRNSDS 974
+ C + C NTEG Y C C L G C D + R D +
Sbjct: 1161 VQNGGC--DVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGG 1218
Query: 975 ECPLSHDGYC---------------LHDGVCMYIEALD---KYACNCVVGYI 1008
L +DG+ L+ +C++ + + + C+C +GY+
Sbjct: 1219 HRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYM 1270
Score = 89.7 bits (221), Expect = 1e-17
Identities = 52/165 (31%), Positives = 68/165 (41%), Gaps = 11/165 (6%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGS 377
C++ C+ C L S C C GY C D++EC+ CT CKNT GS
Sbjct: 2367 CRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGS 2426
Query: 378 YYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLER----DG 433
+ C+CP G++L DG+ C L C C CV T C CP G D
Sbjct: 2427 FLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHHQACFDN 2486
Query: 434 KTCSGCSSP--DNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
CS P +G C +P S+ C+C G+ L C
Sbjct: 2487 DECSAQPGPCGAHGHCHN-----TPGSFRCECHQGFTLVSSGHGC 2526
Score = 89.0 bits (219), Expect = 3e-17
Identities = 59/204 (28%), Positives = 84/204 (41%), Gaps = 21/204 (10%)
Query: 743 DPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTP 802
D C C +CK G+ CSC G++ DG+TC LD + ++
Sbjct: 2407 DECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLD----------ECTSRQHN 2456
Query: 803 LDILSKTRVSEDNITESQHMLVAEIMVSDQDDCA--PVGCSMYARCISEGEDATCQCLKG 860
L V D D+C+ P C + C + C+C +G
Sbjct: 2457 CQFLCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQG 2516
Query: 861 FA--GDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGY--QGDGIHCLDIDEC 916
F G C D++EC+ G C C N GGY C C +G+ C+D +EC
Sbjct: 2517 FTLVSSGHGCEDVNECD-GPHRCQHG---CQNQLGGYRCSCPQGFTQHSQWAQCVDENEC 2572
Query: 917 QLGEHSCGENASCTNTEGGYTCMC 940
L +CG +ASC NT GG+ C+C
Sbjct: 2573 ALSPPTCG-SASCRNTLGGFRCVC 2595
Score = 86.7 bits (213), Expect = 1e-16
Identities = 70/282 (24%), Positives = 105/282 (37%), Gaps = 81/282 (28%)
Query: 743 DPCLYQNGGCEH-ICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVT 801
D C +G C H C +G CSC GF D + C+ ++ ++ GG
Sbjct: 1115 DECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGG--------- 1165
Query: 802 PLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQCLKGF 861
C ++ CI+ C C +G+
Sbjct: 1166 --------------------------------------CDVH--CINTEGSYRCSCGQGY 1185
Query: 862 A--GDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQG--DGIHCLDIDECQ 917
+ DG+ C+D+DECE VC C N GG+ C C +G+ D C+D+DEC
Sbjct: 1186 SLMPDGRACADVDECEENPRVCD--QGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECD 1243
Query: 918 LGEHSCGENASCTNTEGGYTCMCA-GRLSEPGLI-CPDSTPPPHLREDDHHYSVRNSDSE 975
L H C + C NT+G + C C G + G C D D+ N DS
Sbjct: 1244 LNPHIC-LHGDCENTKGSFVCHCQLGYMVRKGATGCSDV--------DECEVGGHNCDSH 1294
Query: 976 CPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDL 1017
C+ I ++C C+ G++G+ + DL
Sbjct: 1295 AS------------CLNIPG--SFSCRCLPGWVGDGFECHDL 1322
Score = 85.1 bits (209), Expect = 4e-16
Identities = 58/197 (29%), Positives = 82/197 (41%), Gaps = 34/197 (17%)
Query: 819 SQHMLVAEIMVSDQDDCAPV-GCSMYARCISEGEDATCQCLKGFAGDG--KLCSDIDECE 875
S+ L D ++C G + C + C C GFA D + C+DIDEC
Sbjct: 974 SRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDECR 1033
Query: 876 MGVPVCPPASSKCINTEGGYVCRCSEGYQGDGI---HCLDIDECQLGEHSCGENASCTNT 932
+ +C C+NT G + C C GY+ + +C+D+DEC C +CTNT
Sbjct: 1034 ISPDLC--GQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLC-RGGTCTNT 1090
Query: 933 EGGYTCMC--AGRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCLHDGVC 990
+G Y C C L+ G C D EC LS DG C H G C
Sbjct: 1091 DGSYKCQCPPGHELTAKGTACEDI-------------------DECSLS-DGLCPH-GQC 1129
Query: 991 MYIEALDKYACNCVVGY 1007
+ + + C+C G+
Sbjct: 1130 --VNVIGAFQCSCHAGF 1144
Score = 84.0 bits (206), Expect = 8e-16
Identities = 59/202 (29%), Positives = 84/202 (41%), Gaps = 14/202 (6%)
Query: 756 CKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLDILSKTRVSEDN 815
C+ G+ C C+ G+M C +D ++ G D + R
Sbjct: 1254 CENTKGSFVCHCQLGYMVRKGATGCSDVDECEV-GGHNCDSHASCLNIPGSFSCRCLPGW 1312
Query: 816 ITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQCLKGFAGDGKLCSDIDECE 875
+ + + VS + C+P G C++ C C +GFAGDG C D DEC
Sbjct: 1313 VGDGFECHDLDECVSQEHRCSPRG-----DCLNVPGSYRCTCRQGFAGDGFFCEDRDECA 1367
Query: 876 MGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIH--CLDIDECQLGEHSCGENASCTNTE 933
V +C + +C+N GGY C C G+ H C D+DEC G + C SC N
Sbjct: 1368 ENVDLCD--NGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQG-NLCA-FGSCENLP 1423
Query: 934 GGYTCMCAG--RLSEPGLICPD 953
G + C+C G L G C D
Sbjct: 1424 GMFRCICNGGYELDRGGGNCTD 1445
Score = 83.6 bits (205), Expect = 1e-15
Identities = 60/219 (27%), Positives = 89/219 (40%), Gaps = 23/219 (10%)
Query: 741 GADPCLYQNGGCEH-ICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQ 799
G + C C H C G+ C C GF ++D C+ +D G KN
Sbjct: 1805 GRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGTCKNI 1864
Query: 800 VTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSM--YARCISEGEDATCQC 857
+ + L +T + + D D+C + + + C++ C C
Sbjct: 1865 IGSYNCLCFPGFV---VTHNGDCV-------DFDECTTLVGQVCRFGHCLNTAGSFHCLC 1914
Query: 858 LKGF--AGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCLDIDE 915
GF DGK C D +EC C P + C N EG + C C G+Q HC+DIDE
Sbjct: 1915 QDGFELTADGKNCVDTNECLSLAGTCLPGT--CQNLEGSFRCICPPGFQVQSDHCIDIDE 1972
Query: 916 CQLGEHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDS 954
C + C +CTN+ G + C+C PG + D+
Sbjct: 1973 CSEEPNLC-LFGTCTNSPGSFQCLC-----PPGFVLSDN 2005
Score = 80.1 bits (196), Expect = 1e-14
Identities = 53/168 (31%), Positives = 71/168 (42%), Gaps = 13/168 (7%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLG-CKNTPG 376
CK+ G C+ C + S C CA G+AL + C D++EC C G C NTPG
Sbjct: 990 CKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPG 1049
Query: 377 SYYCTC----PVGFVLLPDGKRCHQLVSCPRNVSEC-SHDCVLTSEGPLCFCPEGSVLER 431
S+ C C GF+L+ K C + C R+ C C T C CP G L
Sbjct: 1050 SFECECFPGYESGFMLM---KNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTA 1106
Query: 432 DGKTCSG---CSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
G C CS D CV + +++C C G+ D + C
Sbjct: 1107 KGTACEDIDECSLSDGLCPHGQCVNVIG-AFQCSCHAGFQSTPDRQGC 1153
Score = 78.2 bits (191), Expect = 4e-14
Identities = 53/170 (31%), Positives = 68/170 (40%), Gaps = 20/170 (11%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCT--LGCKNTP 375
C L C C S +C C GY + + C DV+EC H C C N P
Sbjct: 1242 CDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIP 1301
Query: 376 GSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECS--HDCVLTSEGPLCFCPEGSVLERDG 433
GS+ C C G+V DG CH L C CS DC+ C C +G DG
Sbjct: 1302 GSFSCRCLPGWV--GDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQG--FAGDG 1357
Query: 434 KTCSG---CSSP----DNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
C C+ DNG C +P + C+C G+D D ++C
Sbjct: 1358 FFCEDRDECAENVDLCDNGQCLN-----APGGYRCECEMGFDPTEDHRAC 1402
Score = 76.6 bits (187), Expect = 1e-13
Identities = 46/146 (31%), Positives = 59/146 (40%), Gaps = 4/146 (2%)
Query: 325 CSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGC--TLGCKNTPGSYYCTC 382
C++ +C + S C C G+ + CEDV+EC C C N PGSY C C
Sbjct: 1732 CANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKC 1791
Query: 383 PVGFVLLPDGKRCHQLVSCPRNVSECSH-DCVLTSEGPLCFCPEGSVLERDGKTCSGCSS 441
G+ L P G C C + CSH DC+ T +C C G D C
Sbjct: 1792 TRGYKLSPGG-ACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDE 1850
Query: 442 PDNGGCSQLCVPLSPVSWECDCFPGY 467
D C S+ C CFPG+
Sbjct: 1851 CDRQPCGNGTCKNIIGSYNCLCFPGF 1876
Score = 75.9 bits (185), Expect = 2e-13
Identities = 51/166 (30%), Positives = 73/166 (43%), Gaps = 20/166 (12%)
Query: 831 DQDDCAPVG--CSMYARCISEGEDATCQCLKGFAGDGKL--CSDIDECEMGVPVCPPASS 886
D D+C + C+ + CI+ C C G+ D C D+DEC V P +
Sbjct: 2363 DVDECRMLAHLCA-HGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQ---VPKPCTF 2418
Query: 887 KCINTEGGYVCRCSEGY--QGDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMCAGRL 944
C NT+G ++C C GY + DG C D+DEC +H+C C NT G +TC C
Sbjct: 2419 LCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNC--QFLCVNTVGAFTCRCPPGF 2476
Query: 945 SEPGLICPD-----STPPPHLREDDHHYSVRNSDSECPLSHDGYCL 985
++ C D + P P H + + EC H G+ L
Sbjct: 2477 TQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCEC---HQGFTL 2519
Score = 75.5 bits (184), Expect = 3e-13
Identities = 48/146 (32%), Positives = 64/146 (43%), Gaps = 14/146 (9%)
Query: 339 CMCAEGYALSRDRKYCEDVNECAFWNHGCTLG-CKNTPGSYYCTCPVGFVLLPDGKRCHQ 397
C C G+ + R+ C DV+EC C LG C NT GS+ C C GF L PDGK C
Sbjct: 472 CRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVD 531
Query: 398 LVSCPRNVSECSHDCVLTSEGPL-CFCPEGSVLERDGKTC---SGCSSPD---NGGCSQL 450
C + + C + L +G C C G +L G C C +P NG C+
Sbjct: 532 HNECATS-TMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTN- 589
Query: 451 CVPLSPVSWECDCFPGYDLQLDEKSC 476
+ S+ C C G + D + C
Sbjct: 590 ----TEGSFRCQCLGGLAVGTDGRVC 611
Score = 75.5 bits (184), Expect = 3e-13
Identities = 47/132 (35%), Positives = 65/132 (49%), Gaps = 14/132 (10%)
Query: 831 DQDDCAPVG--CSMYARCISEGEDATCQCLKGF--AGDGKLCSDIDECEMGVPVCPPASS 886
D D+C G C + RC++ C C GF + DGK C D +EC +C +
Sbjct: 489 DVDECIVSGGLCHL-GRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATST-MC--VNG 544
Query: 887 KCINTEGGYVCRCSEGY--QGDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMCAGRL 944
C+N +G + C C G+ G +C+DIDECQ N CTNTEG + C C G L
Sbjct: 545 VCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTP--GICVNGHCTNTEGSFRCQCLGGL 602
Query: 945 S--EPGLICPDS 954
+ G +C D+
Sbjct: 603 AVGTDGRVCVDT 614
Score = 74.7 bits (182), Expect = 5e-13
Identities = 57/203 (28%), Positives = 77/203 (37%), Gaps = 19/203 (9%)
Query: 743 DPCLYQNGGCEH-ICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVT 801
D C C H C LG+ C C+ G+ + TCL +D +
Sbjct: 2365 DECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMD----------ECSQVPK 2414
Query: 802 PLDILSKTRVSEDNITESQHMLVAE--IMVSDQDDCAPVGCSMYARCISEGEDATCQCLK 859
P L K + + L+ E D D+C + C++ TC+C
Sbjct: 2415 PCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPP 2474
Query: 860 GFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQ--GDGIHCLDIDECQ 917
GF + C D DEC C A C NT G + C C +G+ G C D++EC
Sbjct: 2475 GFTQHHQACFDNDECSAQPGPC-GAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECD 2533
Query: 918 LGEHSCGENASCTNTEGGYTCMC 940
G H C C N GGY C C
Sbjct: 2534 -GPHRC--QHGCQNQLGGYRCSC 2553
Score = 74.3 bits (181), Expect = 6e-13
Identities = 53/165 (32%), Positives = 72/165 (43%), Gaps = 18/165 (10%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLG-CKNTPG 376
C+ CS C S++C+C G+ S D+ C D++EC C G CKN G
Sbjct: 1809 CREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECD--RQPCGNGTCKNIIG 1866
Query: 377 SYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSH--DCVLTSEGPLCFCPEGSVLERDGK 434
SY C C GFV+ +G C C V + C+ T+ C C +G L DGK
Sbjct: 1867 SYNCLCFPGFVVTHNGD-CVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGK 1925
Query: 435 TCSGCSSPDNGGCSQL---CVPLS----PVSWECDCFPGYDLQLD 472
C D C L C+P + S+ C C PG+ +Q D
Sbjct: 1926 NC-----VDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSD 1965
Score = 74.3 bits (181), Expect = 6e-13
Identities = 48/141 (34%), Positives = 65/141 (46%), Gaps = 11/141 (7%)
Query: 831 DQDDCAP-VGCSMYARCISEGEDATCQCLKGFAGD--GKLCSDIDECEMGVPVCPPASSK 887
D ++CA G C++ C+C G++ D G C D DEC +G P
Sbjct: 2084 DVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPC---GQGT 2140
Query: 888 CINTEGGYVCRCSEGYQ-GDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMCAG--RL 944
C N GG+ C C++G++ G + C DIDEC L C C NTEG Y C C L
Sbjct: 2141 CTNVIGGFECACADGFEPGLMMTCEDIDECSLNPLLCA--FRCHNTEGSYLCTCPAGYTL 2198
Query: 945 SEPGLICPDSTPPPHLREDDH 965
E G +C D ++D H
Sbjct: 2199 REDGAMCRDVDECADGQQDCH 2219
Score = 73.2 bits (178), Expect = 1e-12
Identities = 48/154 (31%), Positives = 64/154 (41%), Gaps = 17/154 (11%)
Query: 325 CSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPV 384
C C + C CA+G+ CED++EC+ C C NT GSY CTCP
Sbjct: 2136 CGQGTCTNVIGGFECACADGFEPGL-MMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPA 2194
Query: 385 GFVLLPDGKRCHQLVSCPRNVSEC---SHDCVLTSEGPLCFCPEG-SVLERDGKTCSG-- 438
G+ L DG C + C +C +C C CP G L G+ C+
Sbjct: 2195 GYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDN 2254
Query: 439 -C-SSPD---NGGCSQLCVPLSPVSWECDCFPGY 467
C + PD NG C + S+ CDC G+
Sbjct: 2255 ECHAQPDLCVNGRCVN-----TAGSFRCDCDEGF 2283
Score = 70.9 bits (172), Expect = 7e-12
Identities = 41/115 (35%), Positives = 55/115 (47%), Gaps = 10/115 (8%)
Query: 831 DQDDCAP--VGCSMYARCISEGEDATCQCLKGF-AGDGKLCSDIDECEMGVPVCPPASSK 887
D D+C C A CI+ C+C +G+ G C +EC VC +
Sbjct: 1763 DVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGACVGRNECREIPNVC--SHGD 1820
Query: 888 CINTEGGYVCRCSEGYQ--GDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMC 940
C++TEG Y+C C G+Q D C+DIDEC CG N +C N G Y C+C
Sbjct: 1821 CMDTEGSYMCLCHRGFQASADQTLCMDIDECD--RQPCG-NGTCKNIIGSYNCLC 1872
Score = 70.1 bits (170), Expect = 1e-11
Identities = 44/121 (36%), Positives = 57/121 (47%), Gaps = 4/121 (3%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLG-CKNTPG 376
C L C++ VC S+ C+C GY K C DV+ECA + C G C+N+PG
Sbjct: 686 CALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPG 745
Query: 377 SYYCTCPVGFVLLPDGKRCHQLVSCPRNVSEC-SHDCVLTSEGPLCFCPEGSVLERDGKT 435
SY C+CP GF D + C + C S C S C + C C GS L+ G
Sbjct: 746 SYSCSCPPGFHFWQDTEICKDVDECLS--SPCVSGVCRNLAGSYTCKCGPGSRLDPSGTF 803
Query: 436 C 436
C
Sbjct: 804 C 804
Score = 70.1 bits (170), Expect = 1e-11
Identities = 49/160 (30%), Positives = 67/160 (41%), Gaps = 14/160 (8%)
Query: 325 CSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECA-FWNHGCTLG-CKNTPGSYYCTC 382
C + C + S+ C+C G+ ++ + C D +EC C G C NT GS++C C
Sbjct: 1856 CGNGTCKNIIGSYNCLCFPGFVVTHNGD-CVDFDECTTLVGQVCRFGHCLNTAGSFHCLC 1914
Query: 383 PVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPL-CFCPEGSVLERDG-KTCSGCS 440
GF L DGK C C C EG C CP G ++ D CS
Sbjct: 1915 QDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECS 1974
Query: 441 SPDN----GGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
N G C+ SP S++C C PG+ L + C
Sbjct: 1975 EEPNLCLFGTCTN-----SPGSFQCLCPPGFVLSDNGHRC 2009
Score = 69.3 bits (168), Expect = 2e-11
Identities = 57/215 (26%), Positives = 84/215 (39%), Gaps = 28/215 (13%)
Query: 738 AKPGADPCLYQNGGCEH-ICKKRLGTAWCSCREGFMKASDGKTCLALD----GHQLLAGG 792
++ + C G C + +C G+ C C G+ G C+ D GH
Sbjct: 2081 SREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPC---- 2136
Query: 793 EVDLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCA--PVGCSMYARCISEG 850
Q T +++ + + E M+ E D D+C+ P+ C+ RC +
Sbjct: 2137 -----GQGTCTNVIGGFECACADGFEPGLMMTCE----DIDECSLNPLLCAF--RCHNTE 2185
Query: 851 EDATCQCLKGFA--GDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQ---G 905
C C G+ DG +C D+DEC G C +C N G + C C G + G
Sbjct: 2186 GSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPG 2245
Query: 906 DGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMC 940
G C D +EC C N C NT G + C C
Sbjct: 2246 SGEGCTDDNECHAQPDLC-VNGRCVNTAGSFRCDC 2279
Score = 69.3 bits (168), Expect = 2e-11
Identities = 36/110 (32%), Positives = 46/110 (41%), Gaps = 1/110 (0%)
Query: 330 CGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGC-TLGCKNTPGSYYCTCPVGFVL 388
C L + C C +G+ C D NECA C + C+NT G + C CP GF
Sbjct: 2542 CQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDF 2601
Query: 389 LPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSG 438
C ++ C CS+ C T G LC CP+G G SG
Sbjct: 2602 DQALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGYFRAGQGHCVSG 2651
Score = 68.2 bits (165), Expect = 5e-11
Identities = 60/219 (27%), Positives = 84/219 (38%), Gaps = 45/219 (20%)
Query: 755 ICKKRLGTAWCSCREGFMKASDGKTCLALD----------GH----------QLLAGGEV 794
+C G+ C C+ GF+ A G C+ +D GH Q L G V
Sbjct: 545 VCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAV 604
Query: 795 DLKNQVT-----------PLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMY 843
+V ++ S R +T+S E ++ D C +
Sbjct: 605 GTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKS------ECCCANPDHGFGEPCQLC 658
Query: 844 ARCISEGEDATCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGY 903
S A C G DG+ DI+EC + VC A+ C N G Y C C+ GY
Sbjct: 659 PAKDSAEFQALCSSGLGITTDGR---DINECALDPEVC--ANGVCENLRGSYRCVCNLGY 713
Query: 904 Q--GDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMC 940
+ G C D+DEC L C +N C N+ G Y+C C
Sbjct: 714 EAGASGKDCTDVDECALNSLLC-DNGWCQNSPGSYSCSC 751
Score = 68.2 bits (165), Expect = 5e-11
Identities = 44/160 (27%), Positives = 69/160 (43%), Gaps = 6/160 (3%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLG-CKNTPG 376
C+ G C C S C C GY LS + CED++EC+ + C G C NT G
Sbjct: 1567 CQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLG 1626
Query: 377 SYYCTCPVGFVLLPDGKRCHQLVS--CPRNVS-ECSHDCVLTSEGPLCFCPEGSVLERDG 433
+Y C CP ++ + G C + C R+ + C ++ +C C ++ +
Sbjct: 1627 NYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCC-SYNIGQAWN 1685
Query: 434 KTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDE 473
+ C C +P + LC +P + D G L +DE
Sbjct: 1686 RPCEACPTPISPDYQILCGNQAP-GFLTDIHTGKPLDIDE 1724
Score = 67.4 bits (163), Expect = 8e-11
Identities = 41/114 (35%), Positives = 53/114 (46%), Gaps = 10/114 (8%)
Query: 845 RCISEGEDATCQCLKGFAGDGK-LCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGY 903
RC+ C+C G+ D + C D+DEC P C+N G Y CRC G+
Sbjct: 423 RCLPTPSSYRCECNVGYTQDVRGECIDVDECTSS----PCHHGDCVNIPGTYHCRCYPGF 478
Query: 904 QGDGIH--CLDIDECQLGEHSCGENASCTNTEGGYTCMC-AG-RLSEPGLICPD 953
Q C+D+DEC + C C NTEG + C+C AG LS G C D
Sbjct: 479 QATPTRQACVDVDECIVSGGLC-HLGRCVNTEGSFQCVCNAGFELSPDGKNCVD 531
Score = 67.0 bits (162), Expect = 1e-10
Identities = 46/152 (30%), Positives = 56/152 (36%), Gaps = 6/152 (3%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGS 377
C + G C C S C+C G+ LS D K C D NECA C N GS
Sbjct: 493 CIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGS 552
Query: 378 YYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTC- 436
+ C C GF+L P G C + C + C T C C G + DG+ C
Sbjct: 553 FSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCV 612
Query: 437 -----SGCSSPDNGGCSQLCVPLSPVSWECDC 463
S C G P + EC C
Sbjct: 613 DTHVRSTCYGAIEKGSCARPFPGTVTKSECCC 644
Score = 66.2 bits (160), Expect = 2e-10
Identities = 49/185 (26%), Positives = 64/185 (34%), Gaps = 48/185 (25%)
Query: 329 VCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGC------TLG------------ 370
+C S LC C GY L D + C+D++EC H C T+G
Sbjct: 2419 LCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQ 2478
Query: 371 -----------------------CKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSE 407
C NTPGS+ C C GF L+ G C + C
Sbjct: 2479 HHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECD-GPHR 2537
Query: 408 CSHDCVLTSEGPLCFCPEGSVLERDGKTC---SGCS-SPDNGGCSQLCVPLSPVSWECDC 463
C H C G C CP+G C + C+ SP G + L + C C
Sbjct: 2538 CQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLG--GFRCVC 2595
Query: 464 FPGYD 468
G+D
Sbjct: 2596 PSGFD 2600
Score = 65.5 bits (158), Expect = 3e-10
Identities = 37/123 (30%), Positives = 52/123 (42%), Gaps = 3/123 (2%)
Query: 325 CSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPV 384
C + C + C C G+ + D + C+DV+ECA N C+N PG + C C
Sbjct: 1373 CDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNG 1432
Query: 385 GFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDN 444
G+ L G C + C V+ + C+ T LC CP+ L G GC
Sbjct: 1433 GYELDRGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSG---VGCVDTRA 1489
Query: 445 GGC 447
G C
Sbjct: 1490 GNC 1492
Score = 65.1 bits (157), Expect = 4e-10
Identities = 44/138 (31%), Positives = 59/138 (42%), Gaps = 8/138 (5%)
Query: 870 DIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGI--HCLDIDECQLGEHSCGENA 927
DIDEC +C A+ CIN G + C C G+ + I C D+DEC E C +NA
Sbjct: 1721 DIDECGEIPAIC--ANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNA 1778
Query: 928 SCTNTEGGYTCMCA-GRLSEPGLICPDSTPPPHLREDDHHYSVRNSD-SECPLSHDGY-- 983
C N G Y C C G PG C + H +++ S L H G+
Sbjct: 1779 DCINIPGSYRCKCTRGYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQA 1838
Query: 984 CLHDGVCMYIEALDKYAC 1001
+CM I+ D+ C
Sbjct: 1839 SADQTLCMDIDECDRQPC 1856
Score = 64.7 bits (156), Expect = 5e-10
Identities = 44/132 (33%), Positives = 55/132 (41%), Gaps = 8/132 (6%)
Query: 308 DDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGC 367
DD+ E + C G C++ VC S C C GY+L C D +EC+ H C
Sbjct: 2079 DDSREDVNE-CAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSV-GHPC 2136
Query: 368 TLG-CKNTPGSYYCTCPVGFV--LLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCP 424
G C N G + C C GF L+ C + C N C+ C T LC CP
Sbjct: 2137 GQGTCTNVIGGFECACADGFEPGLM---MTCEDIDECSLNPLLCAFRCHNTEGSYLCTCP 2193
Query: 425 EGSVLERDGKTC 436
G L DG C
Sbjct: 2194 AGYTLREDGAMC 2205
Score = 63.9 bits (154), Expect = 9e-10
Identities = 60/217 (27%), Positives = 84/217 (38%), Gaps = 33/217 (15%)
Query: 742 ADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVT 801
A P L NG C + G+ C C EGF + C H + G Q
Sbjct: 2258 AQPDLCVNGRCVNTA----GSFRCDCDEGFQPSPTLTEC-----HDIRQGPCFAEVLQTM 2308
Query: 802 PLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPV-GCSMYARCISEGEDATCQCLKG 860
+ S S + +T ++ + + P+ G S Y + G G
Sbjct: 2309 CRSLSS----SSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGS--------G 2356
Query: 861 FAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGD--GIHCLDIDECQL 918
+ +G+ D+DEC M +C A +CIN+ G + C C GY D CLD+DEC
Sbjct: 2357 YTAEGR---DVDECRMLAHLC--AHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQ 2411
Query: 919 GEHSCGENASCTNTEGGYTCMC--AGRLSEPGLICPD 953
C C NT+G + C C L E G C D
Sbjct: 2412 VPKPC--TFLCKNTKGSFLCSCPRGYLLEEDGRTCKD 2446
Score = 62.8 bits (151), Expect = 2e-09
Identities = 42/139 (30%), Positives = 58/139 (41%), Gaps = 8/139 (5%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLG-CKNTPG 376
C G C C S C+C G+ + D +C D++EC+ + C G C N+PG
Sbjct: 1933 CLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSD--HCIDIDECSEEPNLCLFGTCTNSPG 1990
Query: 377 SYYCTCPVGFVLLPDGKRC---HQLVSCPR-NVSECSHDCVLTSEGPLCFCPEGSVLERD 432
S+ C CP GFVL +G RC Q R +CS + C C + E
Sbjct: 1991 SFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPG-EGW 2049
Query: 433 GKTCSGCSSPDNGGCSQLC 451
G C C + +LC
Sbjct: 2050 GDPCELCPQEGSAAFQELC 2068
Score = 61.6 bits (148), Expect = 4e-09
Identities = 47/160 (29%), Positives = 67/160 (41%), Gaps = 18/160 (11%)
Query: 317 LCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAF--WNHGCTLGCKNT 374
+C+ C + C S+ C C GY R C DV+EC +HG C N
Sbjct: 411 ICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDV-RGECIDVDECTSSPCHHG---DCVNI 466
Query: 375 PGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPL-CFCPEGSVLERDG 433
PG+Y+C C GF P + C + C + C + +EG C C G L DG
Sbjct: 467 PGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDG 526
Query: 434 KTCSGCSSPDNGGCSQLCVPLSPV------SWECDCFPGY 467
K C D+ C+ + ++ V S+ C C PG+
Sbjct: 527 KNC-----VDHNECATSTMCVNGVCLNEDGSFSCLCKPGF 561
Score = 58.9 bits (141), Expect = 3e-08
Identities = 44/156 (28%), Positives = 64/156 (41%), Gaps = 27/156 (17%)
Query: 319 KLRKGNCSSTVCGQDLQSHLCM------------------CAEGYALSRDRKYCEDVNEC 360
K+++ C + G L+S C CA G+A C+DVNEC
Sbjct: 815 KIQESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGVT-CDDVNEC 873
Query: 361 AFWNHGCTLG-CKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEG- 418
+ C G C NT GS+ C CP G +L G+ C + P + +C +T G
Sbjct: 874 ESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGK 933
Query: 419 ---PLCFCPEGSVLERDGKTCSGCSSPDNGGCSQLC 451
+C C G+V G C C P++ + LC
Sbjct: 934 YRMDVCCCSIGAVW---GVECEACPDPESLEFASLC 966
Score = 58.9 bits (141), Expect = 3e-08
Identities = 24/73 (32%), Positives = 35/73 (47%)
Query: 314 EQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKN 373
++ C L C S C L C+C G+ + C++V+ECA C+ C N
Sbjct: 2568 DENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSYSCAN 2627
Query: 374 TPGSYYCTCPVGF 386
TPG + C CP G+
Sbjct: 2628 TPGGFLCGCPQGY 2640
Score = 58.5 bits (140), Expect = 4e-08
Identities = 70/248 (28%), Positives = 94/248 (37%), Gaps = 36/248 (14%)
Query: 743 DPCLYQNGGC--EHICKKRLGTAWCSCREGFMKASDGKTCLAL---DGHQLLAGGEVDLK 797
D C Q G C C G+ C C +GF S G C + DG G +
Sbjct: 2487 DECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQHG---CQ 2543
Query: 798 NQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCA--PVGCSMYARCISEGEDATC 855
NQ L R S +QH A+ + D+++CA P C A C + C
Sbjct: 2544 NQ------LGGYRCSCPQ-GFTQHSQWAQCV--DENECALSPPTCGS-ASCRNTLGGFRC 2593
Query: 856 QCLKGFAGDGKL--CSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGY--QGDGIHCL 911
C GF D L C ++DEC P S C NT GG++C C +GY G G HC+
Sbjct: 2594 VCPSGFDFDQALGGCQEVDEC---AGRRGPCSYSCANTPGGFLCGCPQGYFRAGQG-HCV 2649
Query: 912 DIDECQLGEHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHLREDDHHYSVRN 971
G + ++E Y C G + P P DH ++
Sbjct: 2650 SGLGFSPGPQDTPDKEELLSSEACYECKING-------LSPRDRPRRSAHR-DHQVNLAT 2701
Query: 972 SDSECPLS 979
DSE L+
Sbjct: 2702 LDSEALLT 2709
Score = 56.2 bits (134), Expect = 2e-07
Identities = 30/76 (39%), Positives = 37/76 (48%), Gaps = 5/76 (6%)
Query: 867 LCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGY--QGDGIHCLDIDECQLGEHSCG 924
+ DIDEC+ +C C+NT G + C C GY C DIDEC CG
Sbjct: 1560 ILEDIDECQELPGLCQ--GGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICG 1617
Query: 925 ENASCTNTEGGYTCMC 940
+C NT G YTC+C
Sbjct: 1618 P-GTCYNTLGNYTCVC 1632
Score = 55.5 bits (132), Expect = 3e-07
Identities = 63/228 (27%), Positives = 90/228 (39%), Gaps = 33/228 (14%)
Query: 743 DPCLYQNGGCEHI--CKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQV 800
D C+ Q C C G+ C+CR+GF A DG C D VDL +
Sbjct: 1323 DECVSQEHRCSPRGDCLNVPGSYRCTCRQGF--AGDGFFCEDRDE----CAENVDLCDNG 1376
Query: 801 TPLDILSKTRVSED---NITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQC 857
L+ R + + TE D D+CA + C + C C
Sbjct: 1377 QCLNAPGGYRCECEMGFDPTEDHRAC------QDVDECAQGNLCAFGSCENLPGMFRCIC 1430
Query: 858 LKGFAGD--GKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQ--GDGIHCLD- 912
G+ D G C+DI+EC V + CINT G Y+C C + ++ G+ C+D
Sbjct: 1431 NGGYELDRGGGNCTDINECADPVNCI---NGVCINTPGSYLCSCPQDFELNPSGVGCVDT 1487
Query: 913 -IDECQLGEHSCGENASCTNTEGGY-----TCMCA-GRL-SEPGLICP 952
C L H G++ + E G +C C+ GR P +CP
Sbjct: 1488 RAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCP 1535
Score = 53.5 bits (127), Expect = 1e-06
Identities = 56/198 (28%), Positives = 82/198 (41%), Gaps = 25/198 (12%)
Query: 828 MVSDQDDCAPVGCSMYAR---CISEGEDATCQCLKGFA---GDGKLCSDIDECEMGVPVC 881
M D D+CA +AR C + C C G G G+ C+D +EC +C
Sbjct: 2204 MCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLC 2263
Query: 882 PPASSKCINTEGGYVCRCSEGYQGDG--IHCLDIDE----CQLGEHSCGENASCTNTEGG 935
+ +C+NT G + C C EG+Q C DI + ++ + C +S +
Sbjct: 2264 --VNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTR 2321
Query: 936 YTCMC-AGRLSEPGL-ICPDSTPPPHLREDDH--HYSVRNSD-SEC-PLSHDGYCLHDGV 989
C C GR P +CP + + H Y+ D EC L+H C H G
Sbjct: 2322 AECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAH--LCAH-GE 2378
Query: 990 CMYIEALDKYACNCVVGY 1007
C I +L + C+C GY
Sbjct: 2379 C--INSLGSFRCHCQAGY 2394
Score = 53.1 bits (126), Expect = 2e-06
Identities = 38/146 (26%), Positives = 52/146 (35%), Gaps = 43/146 (29%)
Query: 332 QDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLG-CKNTPGSYYCTCPVGFVLLP 390
+D +C+ G ++ D + D+NECA C G C+N GSY C C +G+
Sbjct: 661 KDSAEFQALCSSGLGITTDGR---DINECALDPEVCANGVCENLRGSYRCVCNLGYEAGA 717
Query: 391 DGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDNGGCSQL 450
GK C + C N C DNG C
Sbjct: 718 SGKDCTDVDECALNSLLC----------------------------------DNGWCQN- 742
Query: 451 CVPLSPVSWECDCFPGYDLQLDEKSC 476
SP S+ C C PG+ D + C
Sbjct: 743 ----SPGSYSCSCPPGFHFWQDTEIC 764
Score = 53.1 bits (126), Expect = 2e-06
Identities = 35/97 (36%), Positives = 49/97 (50%), Gaps = 11/97 (11%)
Query: 835 CAPVGCSMYARCISEGEDATCQCLKGFAG-DGKLCSDIDECEMGVPVCPPASSKCINTEG 893
CA +G + + C E + C +GFA G C D++ECE VCP + +C+NT G
Sbjct: 835 CATLGAAWGSPC--ERCEIDPACARGFARMTGVTCDDVNECESFPGVCP--NGRCVNTAG 890
Query: 894 GYVCRCSEGYQGD--GIHCLDI--DECQL--GEHSCG 924
+ C C EG D G C+D+ + C L E CG
Sbjct: 891 SFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECG 927
Score = 52.8 bits (125), Expect = 2e-06
Identities = 50/204 (24%), Positives = 78/204 (38%), Gaps = 33/204 (16%)
Query: 827 IMVSDQDDCAPV-GCSMYARCISEGEDATCQCLKGF--AGDGKLCSDIDECEMGVPVCPP 883
+++ D D+C + G C++ C+C G+ + ++C DIDEC +C P
Sbjct: 1559 VILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGP 1618
Query: 884 ASSKCINTEGGYVCRCSEGY--QGDGIHCLDIDECQLGEHSCGENASCTN----TEGGYT 937
+ C NT G Y C C Y G +C+D+ + H N +C N
Sbjct: 1619 GT--CYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRH---YNGTCQNELAFNVTRKM 1673
Query: 938 CMCAGRLSE----PGLICPDSTPP----------PHLREDDHHYSVRNSDSECPLSHDGY 983
C C+ + + P CP P P D H + D EC
Sbjct: 1674 CCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDID-ECG-EIPAI 1731
Query: 984 CLHDGVCMYIEALDKYACNCVVGY 1007
C +G+C I + + C C G+
Sbjct: 1732 CA-NGIC--INQIGSFRCECPAGF 1752
Score = 52.4 bits (124), Expect = 3e-06
Identities = 55/195 (28%), Positives = 72/195 (36%), Gaps = 51/195 (26%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVN-ECAF--WNH---GCTLGC 371
C+ G C + C S C C EG L + C DV E F W+ G TL
Sbjct: 873 CESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTL-- 930
Query: 372 KNTPGSY---YCTCPVGFV------LLPDGKRCHQLVSCPR-----------------NV 405
PG Y C C +G V PD + CPR +V
Sbjct: 931 ---PGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDV 987
Query: 406 SE-------CSHDCVLTSEGPL-CFCPEGSVLERDGKTCSGCS----SPDNGGCSQLCVP 453
+E C+H + G C C G L+ + C+ SPD C Q
Sbjct: 988 NECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDL--CGQGTCV 1045
Query: 454 LSPVSWECDCFPGYD 468
+P S+EC+CFPGY+
Sbjct: 1046 NTPGSFECECFPGYE 1060
Score = 51.6 bits (122), Expect = 4e-06
Identities = 36/117 (30%), Positives = 46/117 (39%), Gaps = 7/117 (5%)
Query: 338 LCMCAEGYALSRDRKYCEDVNECAFWNHGCTLG-CKNTPGSYYCTCPVGFVLLPDGKRCH 396
LC EG+ +R ED++EC C G C NT GS+ C CP G+ L + C
Sbjct: 1545 LCPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICE 1604
Query: 397 QLVSCPRNVSECS-HDCVLTSEGPLCFCPEGSVLERDGKTC-----SGCSSPDNGGC 447
+ C + C C T C CP + G C S C NG C
Sbjct: 1605 DIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTC 1661
Score = 47.8 bits (112), Expect = 6e-05
Identities = 66/285 (23%), Positives = 100/285 (35%), Gaps = 48/285 (16%)
Query: 743 DPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTP 802
DP + NG CE++ G+ C C G+ + GK C +D E L + +
Sbjct: 689 DPEVCANGVCENL----RGSYRCVCNLGYEAGASGKDCTDVD--------ECALNSLLCD 736
Query: 803 LDILSKTRVSED-NITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQCLKGF 861
+ S + H + D D+C C + C + TC+C G
Sbjct: 737 NGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPC-VSGVCRNLAGSYTCKCGPGS 795
Query: 862 AGD--GKLCSDIDE-----------CEMGVPVCPPASSKC--INTEGGYVCR-------C 899
D G C D + CE+ + S C + G C C
Sbjct: 796 RLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDPAC 855
Query: 900 SEGY-QGDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMCAG--RLSEPGLICPDSTP 956
+ G+ + G+ C D++EC+ C N C NT G + C C L G +C D
Sbjct: 856 ARGFARMTGVTCDDVNECESFPGVC-PNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRL 914
Query: 957 PPHLREDDHHYSVRNSDSECPLSHDGYCLHDGVCMYIEALDKYAC 1001
P +R + EC ++ G D C I A+ C
Sbjct: 915 EPCF--------LRWDEDECGVTLPGKYRMDVCCCSIGAVWGVEC 951
Score = 46.2 bits (108), Expect = 2e-04
Identities = 43/146 (29%), Positives = 56/146 (38%), Gaps = 27/146 (18%)
Query: 863 GDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGD-GIHCLDIDECQLGEH 921
G L ID C +C + +C+ T Y C C+ GY D C+D+DEC
Sbjct: 401 GTATLNQTIDICRHFTNLC--LNGRCLPTPSSYRCECNVGYTQDVRGECIDVDEC---TS 455
Query: 922 SCGENASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLSHD 981
S + C N G Y C C PG +TP D EC +S
Sbjct: 456 SPCHHGDCVNIPGTYHCRC-----YPGF---QATPTRQACVD---------VDECIVS-G 497
Query: 982 GYCLHDGVCMYIEALDKYACNCVVGY 1007
G C H G C+ E + C C G+
Sbjct: 498 GLC-HLGRCVNTEG--SFQCVCNAGF 520
Score = 45.4 bits (106), Expect = 3e-04
Identities = 47/181 (25%), Positives = 63/181 (34%), Gaps = 36/181 (19%)
Query: 330 CGQDLQSHLCMCAEGYA-LSRDRKYCEDVNECAFWNHGCTLG-CKNTPGSYYCTCPVGFV 387
C + + C+C G L + C D NEC C G C NT GS+ C C GF
Sbjct: 2225 CKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQ 2284
Query: 388 LLPDGKRCHQLVSCP----------RNVSECSHDCVLTSE---------GPLC------- 421
P CH + P R++S S + V +E GP C
Sbjct: 2285 PSPTLTECHDIRQGPCFAEVLQTMCRSLSS-SSEAVTRAECCCGGGRGWGPRCELCPLPG 2343
Query: 422 ------FCPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKS 475
CP GS +G+ C + C+ S S+ C C GY +
Sbjct: 2344 TSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECIN-SLGSFRCHCQAGYTPDATATT 2402
Query: 476 C 476
C
Sbjct: 2403 C 2403
Score = 41.6 bits (96), Expect = 0.005
Identities = 54/242 (22%), Positives = 73/242 (30%), Gaps = 80/242 (33%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVN------------------- 358
C + C + C S C C EG+ S C D+
Sbjct: 2256 CHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSS 2315
Query: 359 -------ECAF-----WNHGCTLGCKNTPGSYYCTCPVGFVLLPDGK------------- 393
EC W C L +Y CP G +G+
Sbjct: 2316 SEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCA 2375
Query: 394 -----------RCH---------------QLVSCPRNVSECSHDCVLTSEGPLCFCPEGS 427
RCH + C + C+ C T LC CP G
Sbjct: 2376 HGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGY 2435
Query: 428 VLERDGKTCSG---CSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQ----LDEKSCAAS- 479
+LE DG+TC C+S + C LCV + ++ C C PG+ D C+A
Sbjct: 2436 LLEEDGRTCKDLDECTSRQH-NCQFLCVN-TVGAFTCRCPPGFTQHHQACFDNDECSAQP 2493
Query: 480 GP 481
GP
Sbjct: 2494 GP 2495
Score = 41.2 bits (95), Expect = 0.006
Identities = 33/135 (24%), Positives = 48/135 (35%), Gaps = 23/135 (17%)
Query: 325 CSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFW----NHGCTLGCKNTPGSYYC 380
C S VC S+ C C G L +C D + W C + + C
Sbjct: 775 CVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSEC 834
Query: 381 TCPVGFVLLPDGKRCHQLVSCPR-----------NVSEC--------SHDCVLTSEGPLC 421
+G +RC +C R +V+EC + CV T+ C
Sbjct: 835 CATLGAAWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRC 894
Query: 422 FCPEGSVLERDGKTC 436
CPEG +L+ G+ C
Sbjct: 895 ECPEGLMLDASGRLC 909
Score = 39.3 bits (90), Expect = 0.023
Identities = 41/143 (28%), Positives = 54/143 (37%), Gaps = 35/143 (24%)
Query: 839 GCSMYARCISEGEDATCQCLKGFAGD------------GKLCSDIDECEMGVPVCPPASS 886
GC RCI C C+ GF G G++ + + ++ VC A
Sbjct: 154 GCHNGGRCIGPNR---CACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKAL- 209
Query: 887 KCINTEG---GYVCR--------CSEGYQGDGIH---CLDIDECQLGEHSCGENASCTNT 932
C T G G C C G+ + IH C D+DECQ C + SC N
Sbjct: 210 -CCATVGRAWGLPCELCPAQPHPCRRGFIPN-IHTGACQDVDECQAVPGLC-QGGSCVNM 266
Query: 933 EGGYTCMC--AGRLSEPGLICPD 953
G + C C RLS+ C D
Sbjct: 267 VGSFHCRCPVGHRLSDSSAACED 289
Score = 38.5 bits (88), Expect = 0.039
Identities = 20/56 (35%), Positives = 26/56 (46%), Gaps = 1/56 (1%)
Query: 341 CAEGYALSRDRKYCEDVNECAFWNHGCTLG-CKNTPGSYYCTCPVGFVLLPDGKRC 395
C G+ + C+DV+EC C G C N GS++C CPVG L C
Sbjct: 232 CRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAAC 287
>gi|10190748 CEGP1 protein [Homo sapiens]
Length = 999
Score = 104 bits (260), Expect = 4e-22
Identities = 61/162 (37%), Positives = 77/162 (47%), Gaps = 8/162 (4%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGS 377
C + G C T H C C G+ L D K C+D++EC N GC CKN GS
Sbjct: 286 CAVNNGGCDRTCKDTSTGVH-CSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGS 344
Query: 378 YYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCS 437
+ C C GF LL D K C + C + C H C+ C C G L G T
Sbjct: 345 FDCGCKKGFKLLTDEKSCQDVDECSLD-RTCDHSCINHPGTFACACNRGYTLY--GFTHC 401
Query: 438 GCS---SPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
G + S +NGGC Q+CV + S+EC C PGY L ++K C
Sbjct: 402 GDTNECSINNGGCQQVCVN-TVGSYECQCHPGYKLHWNKKDC 442
Score = 100 bits (248), Expect = 1e-20
Identities = 54/159 (33%), Positives = 74/159 (46%), Gaps = 11/159 (6%)
Query: 326 SSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAF-WNHGCTLGCKNTPGSYYCTCPV 384
+ +C S+ C C GY + + CED++EC N GC C N PG+Y CTC
Sbjct: 58 ADALCQNTPTSYKCSCKPGY--QGEGRQCEDIDECGNELNGGCVHDCLNIPGNYRCTCFD 115
Query: 385 GFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTC-------S 437
GF+L DG C + C N C H CV C C EG L + TC
Sbjct: 116 GFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGL 175
Query: 438 GCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
C + D+ GCS +C S C+C PG++L +++ C
Sbjct: 176 SCMNKDH-GCSHICKEAPRGSVACECRPGFELAKNQRDC 213
Score = 83.2 bits (204), Expect = 1e-15
Identities = 58/194 (29%), Positives = 81/194 (41%), Gaps = 39/194 (20%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYC----EDVNECAFWNHGCTLGCKN 373
C G C T C + S+ C C EG+ LS ++ C E+ C +HGC+ CK
Sbjct: 132 CLENNGGCQHT-CVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKE 190
Query: 374 TP-GSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERD 432
P GS C C GF L + + C +++C C H C T++GP C C + D
Sbjct: 191 APRGSVACECRPGFELAKNQRDC--ILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTD 248
Query: 433 GKTC------------SGCSS------------------PDNGGCSQLCVPLSPVSWECD 462
G++C S +S +NGGC + C S C
Sbjct: 249 GRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTS-TGVHCS 307
Query: 463 CFPGYDLQLDEKSC 476
C G+ LQLD K+C
Sbjct: 308 CPVGFTLQLDGKTC 321
Score = 83.2 bits (204), Expect = 1e-15
Identities = 58/201 (28%), Positives = 70/201 (34%), Gaps = 58/201 (28%)
Query: 743 DPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTP 802
+ C NGGC+ CK CSC GF DGKTC +D Q G
Sbjct: 284 ETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNG----------- 332
Query: 803 LDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQCLKGF- 861
GC + + I D C C KGF
Sbjct: 333 ------------------------------------GCDHFCKNIVGSFD--CGCKKGFK 354
Query: 862 -AGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGI-HCLDIDECQLG 919
D K C D+DEC + CIN G + C C+ GY G HC D +EC +
Sbjct: 355 LLTDEKSCQDVDECSLD----RTCDHSCINHPGTFACACNRGYTLYGFTHCGDTNECSIN 410
Query: 920 EHSCGENASCTNTEGGYTCMC 940
C + C NT G Y C C
Sbjct: 411 NGGCQQ--VCVNTVGSYECQC 429
Score = 80.1 bits (196), Expect = 1e-14
Identities = 53/194 (27%), Positives = 80/194 (41%), Gaps = 34/194 (17%)
Query: 314 EQKLCKLRKGNCSSTVCGQDLQSHL-CMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCK 372
E+ L + K + S +C + + + C C G+ L+++++ C + C N GC C
Sbjct: 172 EEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILTCNHGNGGCQHSCD 229
Query: 373 NTPGSYYCTCPVGFVLLPDGKRCHQ----------------------------LVSCPRN 404
+T C+C + + DG+ C + + +C N
Sbjct: 230 DTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVN 289
Query: 405 VSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCS--SPDNGGCSQLCVPLSPVSWECD 462
C C TS G C CP G L+ DGKTC NGGC C + S++C
Sbjct: 290 NGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVG-SFDCG 348
Query: 463 CFPGYDLQLDEKSC 476
C G+ L DEKSC
Sbjct: 349 CKKGFKLLTDEKSC 362
Score = 77.0 bits (188), Expect = 1e-13
Identities = 42/114 (36%), Positives = 56/114 (49%), Gaps = 8/114 (7%)
Query: 831 DQDDCAPV--GCSMYARCISEGEDATCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKC 888
D D+CA C A C + C C G+ G+G+ C DIDEC G + C
Sbjct: 45 DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDEC--GNELNGGCVHDC 102
Query: 889 INTEGGYVCRCSEGYQ--GDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMC 940
+N G Y C C +G+ DG +CLD+DEC E++ G +C N G Y C C
Sbjct: 103 LNIPGNYRCTCFDGFMLAHDGHNCLDVDECL--ENNGGCQHTCVNVMGSYECCC 154
Score = 65.9 bits (159), Expect = 2e-10
Identities = 47/140 (33%), Positives = 58/140 (41%), Gaps = 28/140 (20%)
Query: 870 DIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCLDIDECQLGEHSCGENASC 929
D+DEC G+ C A + C NT Y C C GYQG+G C DIDEC E + G C
Sbjct: 45 DVDECAQGLDDCH-ADALCQNTPTSYKCSCKPGYQGEGRQCEDIDECG-NELNGGCVHDC 102
Query: 930 TNTEGGYTCMC--AGRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCLHD 987
N G Y C C L+ G C D EC L ++G C H
Sbjct: 103 LNIPGNYRCTCFDGFMLAHDGHNCLDV-------------------DEC-LENNGGCQH- 141
Query: 988 GVCMYIEALDKYACNCVVGY 1007
C + + Y C C G+
Sbjct: 142 -TC--VNVMGSYECCCKEGF 158
Score = 65.1 bits (157), Expect = 4e-10
Identities = 75/322 (23%), Positives = 108/322 (33%), Gaps = 75/322 (23%)
Query: 743 DPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTP 802
D CL NGGC+H C +G+ C C+EGF + + TC+ H+ G
Sbjct: 130 DECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCI----HRSEEG----------- 174
Query: 803 LDILSKTRVSEDNITESQHMLVA------EIMVSDQDDCAPV------GCSMYARCISEG 850
L ++K E+ VA + +Q DC GC ++G
Sbjct: 175 LSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADG 234
Query: 851 EDATCQCLKGFAGDGKLCSDIDECEMGVPVCPPAS------------------------- 885
+ +C DG+ C + ++ + V S
Sbjct: 235 PECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCD 294
Query: 886 SKCINTEGGYVCRCSEGY--QGDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMC--A 941
C +T G C C G+ Q DG C DIDECQ C + C N G + C C
Sbjct: 295 RTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGC--DHFCKNIVGSFDCGCKKG 352
Query: 942 GRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCLH--------------D 987
+L C D R DH C + GY L+ +
Sbjct: 353 FKLLTDEKSCQDVDECSLDRTCDHSCINHPGTFACACNR-GYTLYGFTHCGDTNECSINN 411
Query: 988 GVC--MYIEALDKYACNCVVGY 1007
G C + + + Y C C GY
Sbjct: 412 GGCQQVCVNTVGSYECQCHPGY 433
Score = 36.6 bits (83), Expect = 0.15
Identities = 13/41 (31%), Positives = 21/41 (51%)
Query: 745 CLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDG 785
C NGGC+ +C +G+ C C G+ + K C+ + G
Sbjct: 407 CSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKG 447
Score = 32.7 bits (73), Expect = 2.1
Identities = 26/96 (27%), Positives = 37/96 (38%), Gaps = 5/96 (5%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNEC--AFWNHGCTLGCKNTP 375
C + G C VC + S+ C C GY L ++K C +V + +L C +
Sbjct: 407 CSINNGGCQQ-VCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKSG 465
Query: 376 GSYYC--TCPVGFVLLPDGKRCHQLVSCPRNVSECS 409
G C C G L D V+ N +CS
Sbjct: 466 GGDGCFLRCHSGIHLSSDVTTIRTSVTFKLNEGKCS 501
>gi|13699830 matrilin 4 isoform 1 precursor [Homo sapiens]
Length = 581
Score = 104 bits (260), Expect = 4e-22
Identities = 70/228 (30%), Positives = 101/228 (44%), Gaps = 27/228 (11%)
Query: 357 VNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTS 416
++ CA HGC C N+PGSY+C C VGFVL D + C + C C H+CV T
Sbjct: 216 IDLCAEGTHGCEHHCVNSPGSYFCHCQVGFVLQQDQRSCRAIDYCSFGNHSCQHECVSTP 275
Query: 417 EGPLCFCPEGSVLERDGKTCSG---CSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDE 473
GP C C EG L+ DG++C C+ D+ GC CV +S+ C C G LQ D
Sbjct: 276 GGPRCHCREGHDLQPDGRSCQVRDLCNGVDH-GCEFQCVS-EGLSYRCLCPEGRQLQADG 333
Query: 474 KS---CAASGPQPFLLFANSQDIRHMHF------------------DGTDYGTL-LSQQM 511
KS C LL S+ +R +F +GT G + S ++
Sbjct: 334 KSCNRCREGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRV 393
Query: 512 GMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEG 559
+ L ++ A A++++ER M G ++E +G
Sbjct: 394 RTEFPLGRYGTAAEVKQAVLAVEYMERGTMTGLALRHMVEHSFSEAQG 441
Score = 88.2 bits (217), Expect = 4e-17
Identities = 40/110 (36%), Positives = 53/110 (48%)
Query: 330 CGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLL 389
C S+ C C G+ L +D++ C ++ C+F NH C C +TPG C C G L
Sbjct: 230 CVNSPGSYFCHCQVGFVLQQDQRSCRAIDYCSFGNHSCQHECVSTPGGPRCHCREGHDLQ 289
Query: 390 PDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGC 439
PDG+ C C C CV C CPEG L+ DGK+C+ C
Sbjct: 290 PDGRSCQVRDLCNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSCNRC 339
Score = 54.7 bits (130), Expect = 5e-07
Identities = 31/83 (37%), Positives = 37/83 (44%), Gaps = 8/83 (9%)
Query: 860 GFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGY--QGDGIHCLDIDECQ 917
G +LC+ ID C G C C+N+ G Y C C G+ Q D C ID C
Sbjct: 206 GLQFQSRLCA-IDLCAEGTHGC---EHHCVNSPGSYFCHCQVGFVLQQDQRSCRAIDYCS 261
Query: 918 LGEHSCGENASCTNTEGGYTCMC 940
G HSC C +T GG C C
Sbjct: 262 FGNHSC--QHECVSTPGGPRCHC 282
Score = 54.3 bits (129), Expect = 7e-07
Identities = 34/106 (32%), Positives = 45/106 (42%), Gaps = 11/106 (10%)
Query: 839 GCSMYARCISEGEDATCQCLKGFA--GDGKLCSDIDECEMGVPVCPPASSKCINTEGGYV 896
GC + C++ C C GF D + C ID C G C +C++T GG
Sbjct: 225 GCEHH--CVNSPGSYFCHCQVGFVLQQDQRSCRAIDYCSFGNHSC---QHECVSTPGGPR 279
Query: 897 CRCSEGY--QGDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMC 940
C C EG+ Q DG C D C +H C C + Y C+C
Sbjct: 280 CHCREGHDLQPDGRSCQVRDLCNGVDHGC--EFQCVSEGLSYRCLC 323
Score = 45.8 bits (107), Expect = 2e-04
Identities = 36/131 (27%), Positives = 54/131 (41%), Gaps = 14/131 (10%)
Query: 743 DPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQV-- 800
D C GCEH C G+ +C C+ GF+ D ++C A+D + G +++
Sbjct: 217 DLCAEGTHGCEHHCVNSPGSYFCHCQVGFVLQQDQRSCRAID---YCSFGNHSCQHECVS 273
Query: 801 TPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQCLKG 860
TP R D + + V +D C V +C+SEG C C +G
Sbjct: 274 TPGGPRCHCREGHDLQPDGRSCQV-------RDLCNGVDHGCEFQCVSEGLSYRCLCPEG 326
Query: 861 --FAGDGKLCS 869
DGK C+
Sbjct: 327 RQLQADGKSCN 337
>gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]
Length = 988
Score = 101 bits (251), Expect = 5e-21
Identities = 54/157 (34%), Positives = 74/157 (47%), Gaps = 12/157 (7%)
Query: 329 VCGQDLQSHLCMCAEGYALSRDRKYCEDVNECA--FWNHGCTLGCKNTPGSYYCTCPVGF 386
+C +S+ C+C GY + K CED++EC ++N GC C N PG+Y CTC GF
Sbjct: 49 ICQNTPKSYKCLCKPGY--KGEGKQCEDIDECENDYYNGGCVHECINIPGNYRCTCFDGF 106
Query: 387 VLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTC-------SGC 439
+L DG C + C N C CV C C G L + TC C
Sbjct: 107 MLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNC 166
Query: 440 SSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
+ D+ GC+ +C CDC PG+DL ++K C
Sbjct: 167 MNKDH-GCAHICRETPKGGVACDCRPGFDLAQNQKDC 202
Score = 99.8 bits (247), Expect = 1e-20
Identities = 60/167 (35%), Positives = 76/167 (45%), Gaps = 10/167 (5%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGS 377
C + G C T C C C G+ L D K C+D+NEC N GC C+NT GS
Sbjct: 245 CAVNNGGCDRT-CKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGS 303
Query: 378 YYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCS 437
+ C C G+ LL D + C + C + C H C+ + C C G +L G T
Sbjct: 304 FECGCRKGYKLLTDERTCQDIDECSFERT-CDHICINSPGSFQCLCHRGYILY--GTTHC 360
Query: 438 G----CSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASG 480
G CS NG C Q CV S+EC C PG L + K C +G
Sbjct: 361 GDVDECSM-SNGSCDQGCVNTKG-SYECVCPPGRRLHWNGKDCVETG 405
Score = 93.2 bits (230), Expect = 1e-18
Identities = 55/165 (33%), Positives = 76/165 (46%), Gaps = 11/165 (6%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYC-----EDVNECAFWNHGCTLGCK 372
C+ G C +C + S+ C C G+ LS ++ C E +N C +HGC C+
Sbjct: 121 CQDNNGGCQQ-ICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMN-CMNKDHGCAHICR 178
Query: 373 NTP-GSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLER 431
TP G C C GF L + K C ++C C H C T GP C C + L
Sbjct: 179 ETPKGGVACDCRPGFDLAQNQKDC--TLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHS 236
Query: 432 DGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
DG+TC + +NGGC + C + C C G+ LQ D K+C
Sbjct: 237 DGRTCIETCAVNNGGCDRTCKD-TATGVRCSCPVGFTLQPDGKTC 280
Score = 91.3 bits (225), Expect = 5e-18
Identities = 56/155 (36%), Positives = 69/155 (44%), Gaps = 9/155 (5%)
Query: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGS 377
C G C + C C C + YAL D + C + CA N GC CK+T
Sbjct: 206 CNYGNGGCQHS-CEDTDTGPTCGCHQKYALHSDGRTC--IETCAVNNGGCDRTCKDTATG 262
Query: 378 YYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCS 437
C+CPVGF L PDGK C + C N C H C T C C +G L D +TC
Sbjct: 263 VRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQ 322
Query: 438 G---CSSPDNGGCSQLCVPLSPVSWECDCFPGYDL 469
CS C +C+ SP S++C C GY L
Sbjct: 323 DIDECSFERT--CDHICIN-SPGSFQCLCHRGYIL 354
Score = 89.0 bits (219), Expect = 3e-17
Identities = 49/140 (35%), Positives = 69/140 (49%), Gaps = 7/140 (5%)
Query: 339 CMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQL 398
C C G+ L++++K C C + N GC C++T C C + L DG+ C +
Sbjct: 187 CDCRPGFDLAQNQKDC--TLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTC--I 242
Query: 399 VSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSS--PDNGGCSQLCVPLSP 456
+C N C C T+ G C CP G L+ DGKTC + +NGGC C +
Sbjct: 243 ETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRN-TV 301
Query: 457 VSWECDCFPGYDLQLDEKSC 476
S+EC C GY L DE++C
Sbjct: 302 GSFECGCRKGYKLLTDERTC 321
Score = 82.4 bits (202), Expect = 2e-15
Identities = 58/210 (27%), Positives = 78/210 (37%), Gaps = 58/210 (27%)
Query: 734 VHPLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGE 793
+H + + C NGGC+ CK CSC GF DGKTC ++
Sbjct: 234 LHSDGRTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDIN--------- 284
Query: 794 VDLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDA 853
E +V++ GC + C +
Sbjct: 285 --------------------------------ECLVNNG------GCDHF--CRNTVGSF 304
Query: 854 TCQCLKGF--AGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDG-IHC 910
C C KG+ D + C DIDEC CIN+ G + C C GY G HC
Sbjct: 305 ECGCRKGYKLLTDERTCQDIDECSFE----RTCDHICINSPGSFQCLCHRGYILYGTTHC 360
Query: 911 LDIDECQLGEHSCGENASCTNTEGGYTCMC 940
D+DEC + SC + C NT+G Y C+C
Sbjct: 361 GDVDECSMSNGSCDQ--GCVNTKGSYECVC 388
Score = 80.5 bits (197), Expect = 9e-15
Identities = 44/133 (33%), Positives = 61/133 (45%), Gaps = 9/133 (6%)
Query: 310 TWEPEQKLCK------LRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFW 363
T +P+ K CK + G C C + S C C +GY L D + C+D++EC+F
Sbjct: 272 TLQPDGKTCKDINECLVNNGGCDH-FCRNTVGSFECGCRKGYKLLTDERTCQDIDECSF- 329
Query: 364 NHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFC 423
C C N+PGS+ C C G++L C + C + C CV T C C
Sbjct: 330 ERTCDHICINSPGSFQCLCHRGYILYGT-THCGDVDECSMSNGSCDQGCVNTKGSYECVC 388
Query: 424 PEGSVLERDGKTC 436
P G L +GK C
Sbjct: 389 PPGRRLHWNGKDC 401
Score = 79.7 bits (195), Expect = 2e-14
Identities = 43/114 (37%), Positives = 56/114 (49%), Gaps = 7/114 (6%)
Query: 831 DQDDCAPV--GCSMYARCISEGEDATCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKC 888
D D+C+ C + A C + + C C G+ G+GK C DIDECE +C
Sbjct: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQCEDIDECENDY-YNGGCVHEC 91
Query: 889 INTEGGYVCRCSEGYQ--GDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMC 940
IN G Y C C +G+ DG +CLD+DECQ C + C N G Y C C
Sbjct: 92 INIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQ--ICVNAMGSYECQC 143
Score = 71.6 bits (174), Expect = 4e-12
Identities = 61/236 (25%), Positives = 86/236 (36%), Gaps = 44/236 (18%)
Query: 743 DPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLA----GGEVDLKN 798
D C NGGC+ IC +G+ C C GF + + TC+ + G +
Sbjct: 119 DECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICR 178
Query: 799 QVTPLDILSKTRVSEDNITESQHMLV--------AEIMVSDQDDCAPVGCSMYARCISEG 850
+ + R D + + + D D GC S+G
Sbjct: 179 ETPKGGVACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDG 238
Query: 851 E-------------DATCQ---------CLKGFA--GDGKLCSDIDECEMGVPVCPPASS 886
D TC+ C GF DGK C DI+EC + C
Sbjct: 239 RTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGC---DH 295
Query: 887 KCINTEGGYVCRCSEGYQ--GDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMC 940
C NT G + C C +GY+ D C DIDEC E +C + C N+ G + C+C
Sbjct: 296 FCRNTVGSFECGCRKGYKLLTDERTCQDIDECSF-ERTC--DHICINSPGSFQCLC 348
Score = 68.9 bits (167), Expect = 3e-11
Identities = 77/286 (26%), Positives = 103/286 (36%), Gaps = 58/286 (20%)
Query: 747 YQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLDIL 806
Y NGGC H C G C+C +GFM A DG CL +D Q GG + V +
Sbjct: 82 YYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQI--CVNAMGSY 139
Query: 807 SKTRVSEDNITESQHMLV----------------AEI------------------MVSDQ 832
S ++++QH + A I + +Q
Sbjct: 140 ECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQ 199
Query: 833 DDCAPV------GCSMYARCISEGEDATCQCLKGFA--GDGKLCSDIDECEMGVPVCPPA 884
DC GC C TC C + +A DG+ C I+ C + C
Sbjct: 200 KDCTLTCNYGNGGCQ--HSCEDTDTGPTCGCHQKYALHSDGRTC--IETCAVNNGGC--- 252
Query: 885 SSKCINTEGGYVCRCSEGY--QGDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMC-- 940
C +T G C C G+ Q DG C DI+EC + C + C NT G + C C
Sbjct: 253 DRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGC--DHFCRNTVGSFECGCRK 310
Query: 941 AGRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCLH 986
+L C D R DH +C L H GY L+
Sbjct: 311 GYKLLTDERTCQDIDECSFERTCDHICINSPGSFQC-LCHRGYILY 355
Score = 63.5 bits (153), Expect = 1e-09
Identities = 47/165 (28%), Positives = 64/165 (38%), Gaps = 31/165 (18%)
Query: 870 DIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCLDIDECQLGEHSCGENASC 929
D+DEC G C + C NT Y C C GY+G+G C DIDEC+ ++ G C
Sbjct: 33 DVDECSEGTDDCH-IDAICQNTPKSYKCLCKPGYKGEGKQCEDIDECENDYYNGGCVHEC 91
Query: 930 TNTEGGYTCMC--AGRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCLHD 987
N G Y C C L+ G C D EC ++G C
Sbjct: 92 INIPGNYRCTCFDGFMLAHDGHNCLDV-------------------DECQ-DNNGGC--Q 129
Query: 988 GVCMYIEALDKYACNCVVGYI----GERCQYRDLKWWELRHAGHG 1028
+C + A+ Y C C G+ C +R + + HG
Sbjct: 130 QIC--VNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHG 172
Score = 62.4 bits (150), Expect = 3e-09
Identities = 38/109 (34%), Positives = 47/109 (43%), Gaps = 13/109 (11%)
Query: 329 VCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVL 388
+C S C+C GY L +C DV+EC+ N C GC NT GSY C CP G L
Sbjct: 336 ICINSPGSFQCLCHRGYILY-GTTHCGDVDECSMSNGSCDQGCVNTKGSYECVCPPGRRL 394
Query: 389 LPDGKRCHQLVSC-------PRNVSECS-----HDCVLTSEGPLCFCPE 425
+GK C + C PR CS C L+ F P+
Sbjct: 395 HWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVESCFLSCPAHTLFVPD 443
Score = 57.8 bits (138), Expect = 6e-08
Identities = 38/155 (24%), Positives = 60/155 (38%), Gaps = 12/155 (7%)
Query: 745 CLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLD 804
CL NGGC+H C+ +G+ C CR+G+ +D +TC +D + + T
Sbjct: 286 CLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDID----------ECSFERTCDH 335
Query: 805 ILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQCLKG--FA 862
I + S + ++L D D+C+ S C++ C C G
Sbjct: 336 ICINSPGSFQCLCHRGYILYGTTHCGDVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLH 395
Query: 863 GDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVC 897
+GK C + +C P A C G C
Sbjct: 396 WNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVESC 430
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 99.4 bits (246), Expect = 2e-20
Identities = 81/275 (29%), Positives = 111/275 (40%), Gaps = 38/275 (13%)
Query: 743 DPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTC-----LALDGHQLLAGGEVD-- 795
D C N C H C +GT +CSC +G A+DG+TC AL H AG + D
Sbjct: 5109 DECAAGNP-CSHSCHNAMGTYYCSCPKGLTIAADGRTCQDIDECALGRHTCHAGQDCDNT 5167
Query: 796 LKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATC 855
+ + + S R + D ++ D ++C + RC + C
Sbjct: 5168 IGSYRCVVRCGSGFRRTSDGLS-----------CQDINECQE-SSPCHQRCFNAIGSFHC 5215
Query: 856 QCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVC--RCSEGY-QGDGIHCLD 912
C G+ G+ C D++EC V C P C NT GGY C C G + + C+D
Sbjct: 5216 GCEPGYQLKGRKCMDVNECRQNV--CRP-DQHCKNTRGGYKCIDLCPNGMTKAENGTCID 5272
Query: 913 IDECQLGEHSCGENASCTNTEGGYTCMCAGRLSEPGLICP-------DSTPPPHLREDDH 965
IDEC+ G H C N C NT G Y C+C G+ P + P P H
Sbjct: 5273 IDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCA----H 5328
Query: 966 HYSVRNSDSECPLSHDGYCLHDG-VCMYIEALDKY 999
S +C + L DG C +E L Y
Sbjct: 5329 QCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPNY 5363
Score = 79.3 bits (194), Expect = 2e-14
Identities = 49/115 (42%), Positives = 56/115 (48%), Gaps = 13/115 (11%)
Query: 847 ISEGEDATCQCLKGFAGD--GKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEG-- 902
IS+G D + QC GF D G C+D DEC G P S C N G Y C C +G
Sbjct: 5083 ISKG-DRSNQCPSGFTLDSVGPFCADEDECAAG----NPCSHSCHNAMGTYYCSCPKGLT 5137
Query: 903 YQGDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCM--CAG--RLSEPGLICPD 953
DG C DIDEC LG H+C C NT G Y C+ C R + GL C D
Sbjct: 5138 IAADGRTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQD 5192
Score = 75.5 bits (184), Expect = 3e-13
Identities = 47/152 (30%), Positives = 67/152 (44%), Gaps = 11/152 (7%)
Query: 341 CAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVS 400
C G+ L +C D +ECA N C+ C N G+YYC+CP G + DG+ C +
Sbjct: 5092 CPSGFTLDSVGPFCADEDECAAGNP-CSHSCHNAMGTYYCSCPKGLTIAADGRTCQDIDE 5150
Query: 401 CP--RNVSECSHDCVLTSEGPLCFCPEGSVLER--DGKTCSGCSS-PDNGGCSQLCVPLS 455
C R+ DC T C GS R DG +C + ++ C Q C +
Sbjct: 5151 CALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESSPCHQRCFN-A 5209
Query: 456 PVSWECDCFPGYDLQ----LDEKSCAASGPQP 483
S+ C C PGY L+ +D C + +P
Sbjct: 5210 IGSFHCGCEPGYQLKGRKCMDVNECRQNVCRP 5241
Score = 75.5 bits (184), Expect = 3e-13
Identities = 68/237 (28%), Positives = 87/237 (36%), Gaps = 41/237 (17%)
Query: 752 CEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLDILSKTRV 811
C H C G+ C C G DGK+C L+ L N T + R
Sbjct: 5326 CAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLER----------LPNYGTQYSSYNLARF 5375
Query: 812 S--EDNITESQHMLVAEIMVSDQDDC--APVGCSMYARCISEGEDATCQCLKGFAGDGKL 867
S +N QH + S + + S R I + C +G
Sbjct: 5376 SPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRK------TCPEGSEASHDT 5429
Query: 868 CSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQ--GDGIHCLDIDECQLGEHSCGE 925
C DIDECE C +C NT G Y C C GYQ +G C DIDEC CG
Sbjct: 5430 CVDIDECE-NTDAC---QHECKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQNVHCGP 5485
Query: 926 NASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHLREDDHHYSVRN---SDSECPLS 979
N C N G Y C+ PP + R+ + ++N +D EC LS
Sbjct: 5486 NRMCFNMRGSYQCI------------DTPCPPNYQRDPVSGFCLKNCPPNDLECALS 5530
Score = 72.4 bits (176), Expect = 2e-12
Identities = 44/140 (31%), Positives = 63/140 (45%), Gaps = 7/140 (5%)
Query: 309 DTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCT 368
D E Q +C+ + +C +T G + +C G + + C D++EC H C
Sbjct: 5230 DVNECRQNVCRPDQ-HCKNTRGGYKC---IDLCPNGMTKAENGT-CIDIDECKDGTHQCR 5284
Query: 369 LG--CKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEG 426
C+NT GSY C CP G+ G+ C + C + C+H C T C CP G
Sbjct: 5285 YNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPG 5344
Query: 427 SVLERDGKTCSGCSSPDNGG 446
L DGK+C+G N G
Sbjct: 5345 QHLLGDGKSCAGLERLPNYG 5364
Score = 68.6 bits (166), Expect = 4e-11
Identities = 60/215 (27%), Positives = 78/215 (36%), Gaps = 41/215 (19%)
Query: 300 PLAQPKAEDDTWEPEQKLCKLRKGNCS-STVCGQDLQSHLCMCAEGYALSRDRKYCEDVN 358
P KAE+ T + CK C + +C S+ C+C GY + C D+N
Sbjct: 5259 PNGMTKAENGTCIDIDE-CKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDIN 5317
Query: 359 ECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCP---------------- 402
EC C C NTPGS+ C CP G LL DGK C L P
Sbjct: 5318 ECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPNYGTQYSSYNLARFSP 5377
Query: 403 --------RNVSECSH-------------DCVLTSEGPLCFCPEGSVLERDGKTCSGCSS 441
++ + SH T CPEGS D TC
Sbjct: 5378 VRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEASHD--TCVDIDE 5435
Query: 442 PDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
+N Q + S++C C PGY L + K+C
Sbjct: 5436 CENTDACQHECKNTFGSYQCICPPGYQLTHNGKTC 5470
Score = 67.0 bits (162), Expect = 1e-10
Identities = 39/118 (33%), Positives = 53/118 (44%), Gaps = 7/118 (5%)
Query: 323 GNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLG--CKNTPGSYYC 380
GN S C + ++ C C +G ++ D + C+D++ECA H C G C NT GSY C
Sbjct: 5114 GNPCSHSCHNAMGTYYCSCPKGLTIAADGRTCQDIDECALGRHTCHAGQDCDNTIGSYRC 5173
Query: 381 T--CPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTC 436
C GF DG C + C + S C C C C G L+ G+ C
Sbjct: 5174 VVRCGSGFRRTSDGLSCQDINECQES-SPCHQRCFNAIGSFHCGCEPGYQLK--GRKC 5228
Score = 65.5 bits (158), Expect = 3e-10
Identities = 53/158 (33%), Positives = 66/158 (41%), Gaps = 18/158 (11%)
Query: 330 CGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCT--CPVGFV 387
C + S C C GY L + RK C DVNEC CKNT G Y C CP G
Sbjct: 5206 CFNAIGSFHCGCEPGYQL-KGRK-CMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNGMT 5263
Query: 388 LLPDGKRCHQLVSCPRNVSECSHD--CVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDNG 445
+G C + C +C ++ C T C CP G + G+ C D
Sbjct: 5264 KAENGT-CIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCM-----DIN 5317
Query: 446 GCSQLCVPLS------PVSWECDCFPGYDLQLDEKSCA 477
C Q+ P + P S++C C PG L D KSCA
Sbjct: 5318 ECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCA 5355
Score = 55.5 bits (132), Expect = 3e-07
Identities = 42/127 (33%), Positives = 54/127 (42%), Gaps = 17/127 (13%)
Query: 341 CAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVS 400
C EG S D C D++EC + C CKNT GSY C CP G+ L +GK C
Sbjct: 5419 CPEGSEASHDT--CVDIDECENTD-ACQHECKNTFGSYQCICPPGYQLTHNGKTC----- 5470
Query: 401 CPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCS-SPDNGGCSQLCVP------ 453
+++ EC V +CF GS D P +G C + C P
Sbjct: 5471 --QDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPNYQRDPVSGFCLKNCPPNDLECA 5528
Query: 454 LSPVSWE 460
LSP + E
Sbjct: 5529 LSPYALE 5535
Score = 51.2 bits (121), Expect = 6e-06
Identities = 30/85 (35%), Positives = 40/85 (47%), Gaps = 7/85 (8%)
Query: 330 CGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGC--TLGCKNTPGSYYC---TCPV 384
C S+ C+C GY L+ + K C+D++EC N C C N GSY C CP
Sbjct: 5446 CKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPP 5505
Query: 385 GFVLLPDGKRCHQLVSCPRNVSECS 409
+ P C L +CP N EC+
Sbjct: 5506 NYQRDPVSGFC--LKNCPPNDLECA 5528
Score = 36.2 bits (82), Expect = 0.19
Identities = 22/74 (29%), Positives = 27/74 (36%), Gaps = 2/74 (2%)
Query: 711 NKRTGKDRVRLQGSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREG 770
N RT R R P H D C C+H CK G+ C C G
Sbjct: 5403 NSRTSLSRTRRTIRKTCPEGSEASHDTCVD-IDEC-ENTDACQHECKNTFGSYQCICPPG 5460
Query: 771 FMKASDGKTCLALD 784
+ +GKTC +D
Sbjct: 5461 YQLTHNGKTCQDID 5474
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.442
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 52,688,968
Number of Sequences: 37866
Number of extensions: 2664244
Number of successful extensions: 12757
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 173
Number of HSP's successfully gapped in prelim test: 151
Number of HSP's that attempted gapping in prelim test: 5851
Number of HSP's gapped (non-prelim): 2930
length of query: 1207
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1093
effective length of database: 13,930,794
effective search space: 15226357842
effective search space used: 15226357842
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.