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Search of human proteins with 164607167
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|164607167 ubiquitin specific peptidase 30 [Homo sapiens]
(517 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|164607167 ubiquitin specific peptidase 30 [Homo sapiens] 1071 0.0
gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens] 71 2e-12
gi|41152235 ubiquitin specific protease 51 [Homo sapiens] 71 3e-12
gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens] 69 8e-12
gi|197116355 ubiquitin specific peptidase 46 isoform 2 [Homo sap... 67 3e-11
gi|31377709 ubiquitin specific peptidase 46 isoform 1 [Homo sapi... 67 3e-11
gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens] 67 3e-11
gi|32698815 ubiquitin thiolesterase 12 [Homo sapiens] 67 3e-11
gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo sapi... 64 3e-10
gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens] 64 4e-10
gi|62243586 ubiquitin-specific protease 21 [Homo sapiens] 63 7e-10
gi|74027267 ubiquitin-specific protease 21 [Homo sapiens] 63 7e-10
gi|109134334 ubiquitin thiolesterase 44 [Homo sapiens] 60 4e-09
gi|109134332 ubiquitin thiolesterase 44 [Homo sapiens] 60 4e-09
gi|22550104 ubiquitin specific protease 32 [Homo sapiens] 58 2e-08
gi|122937412 ubiquitin specific peptidase 45 [Homo sapiens] 57 4e-08
gi|109638751 ubiquitin specific protease 6 [Homo sapiens] 56 7e-08
gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens] 55 1e-07
gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens] 55 1e-07
gi|188497648 ubiquitin specific peptidase 37 [Homo sapiens] 55 2e-07
gi|13994268 ubiquitin-specific protease 26 [Homo sapiens] 55 2e-07
gi|120587027 ubiquitin specific peptidase 31 [Homo sapiens] 54 3e-07
gi|21361749 ubiquitin thioesterase 49 [Homo sapiens] 53 6e-07
gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens] 52 1e-06
gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens] 52 1e-06
gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens] 52 1e-06
gi|75992941 ubiquitin specific protease 16 isoform a [Homo sapiens] 52 1e-06
gi|24234683 ubiquitin specific peptidase 11 [Homo sapiens] 52 1e-06
gi|57529246 ubiquitin thioesterase 19 [Homo sapiens] 50 4e-06
gi|148612811 ubiquitin specific protease 43 [Homo sapiens] 49 8e-06
>gi|164607167 ubiquitin specific peptidase 30 [Homo sapiens]
Length = 517
Score = 1071 bits (2769), Expect = 0.0
Identities = 517/517 (100%), Positives = 517/517 (100%)
Query: 1 MLSSRAEAAMTAADRAIQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERK 60
MLSSRAEAAMTAADRAIQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERK
Sbjct: 1 MLSSRAEAAMTAADRAIQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERK 60
Query: 61 KRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTL 120
KRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTL
Sbjct: 61 KRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTL 120
Query: 121 LHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQ 180
LHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQ
Sbjct: 121 LHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQ 180
Query: 181 PRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQ 240
PRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQ
Sbjct: 181 PRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQ 240
Query: 241 SPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEK 300
SPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEK
Sbjct: 241 SPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEK 300
Query: 301 VEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLG 360
VEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLG
Sbjct: 301 VEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLG 360
Query: 361 HKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGAPKTQIFMNGACSPSLLPTLSAPMP 420
HKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGAPKTQIFMNGACSPSLLPTLSAPMP
Sbjct: 361 HKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGAPKTQIFMNGACSPSLLPTLSAPMP 420
Query: 421 FPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDT 480
FPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDT
Sbjct: 421 FPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDT 480
Query: 481 VRKASLQEVLSSSAYLLFYERVLSRMQHQSQECKSEE 517
VRKASLQEVLSSSAYLLFYERVLSRMQHQSQECKSEE
Sbjct: 481 VRKASLQEVLSSSAYLLFYERVLSRMQHQSQECKSEE 517
>gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens]
Length = 525
Score = 71.2 bits (173), Expect = 2e-12
Identities = 105/455 (23%), Positives = 159/455 (34%), Gaps = 134/455 (29%)
Query: 69 GLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALS 128
GL+NLGNTCFMN ++Q L+ P + F S R + + PS L + L +
Sbjct: 177 GLINLGNTCFMNCIVQALTHTPLL---RDFFLSDRHRCEMQSPS-SCLVCEMSSLFQEFY 232
Query: 129 CQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFD 188
+ LL ++ + ++ +E+QDAHE + ++L+ V H
Sbjct: 233 SGHRSPHIPYK---LLHLVWTHARHLAGYEQQDAHEF---LIAALD--------VLHRHC 278
Query: 189 VHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTF 248
+ P C F G L S++ C+ C H D F
Sbjct: 279 KGDDNGKKANNPNHCNCII-------------DQIFTGGLQSDVTCQVC-HGVSTTIDPF 324
Query: 249 DSLSLSIPAAT---WGHPL-------------------TLDHCLHHFISSESVRDVVCDN 286
+SL +P ++ W PL TL CL F E + +
Sbjct: 325 WDISLDLPGSSTPFW--PLSPGSEGNVVNGESHVSGTTTLTDCLRRFTRPEHL-----GS 377
Query: 287 CTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFN 346
KI+ G H KQL + KLP C HL+R H L+R +
Sbjct: 378 SAKIKCSGC-------HSYQESTKQLTMKKLPIVACFHLKRFE---HSAKLRRKITTYVS 427
Query: 347 EFLMMDIYKYHLLGHKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGAPKTQIFMNGA 406
L +D+ + + K S+ N + + PT LN
Sbjct: 428 FPLELDMTPF-MASSKESRMNGQYQQ--------------PTDSLNNDNK---------- 462
Query: 407 CSPSLLPTLSAPMPFPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNP 466
+ L AVV H G + SGH+ ++ R
Sbjct: 463 -----------------------------YSLFAVVNHQGTLESGHYTSFIRQH------ 487
Query: 467 LSTSNQWLWVSDDTVRKASLQEVLSSSAYLLFYER 501
+QW D + KAS+++VL S YLLFY +
Sbjct: 488 ---KDQWFKCDDAIITKASIKDVLDSEGYLLFYHK 519
>gi|41152235 ubiquitin specific protease 51 [Homo sapiens]
Length = 711
Score = 70.9 bits (172), Expect = 3e-12
Identities = 111/460 (24%), Positives = 168/460 (36%), Gaps = 114/460 (24%)
Query: 56 ITERKKRRKGLV-----PGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEP 110
+ +KKRRK V GL+NLGNTCFMN ++Q L+ P + F S +
Sbjct: 346 VKPKKKRRKKSVYTVGLRGLINLGNTCFMNCIVQALTHIPLL---KDFFLSDKHKCIMTS 402
Query: 111 PSHQYLSLTLLHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVIT 170
PS L + L A+ T LL ++ ++ ++ + +QDAHE I
Sbjct: 403 PS-LCLVCEMSSLFHAMYSGSRTPHIPYK---LLHLIWIHAEHLAGYRQQDAHEFLIAIL 458
Query: 171 SSL-----EDERDRQPRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNH-WKSQHPF 224
L +D ++ + + + + +TC+ S T + W
Sbjct: 459 DVLHRHSKDDSGGQEANNPNCCNCIIDQIFTGGLQSDVTCQACHSVSTTIDPCWDISLDL 518
Query: 225 HGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSE---SVRD 281
G C + Q+P R D+ S IP G P +L CL F E S
Sbjct: 519 PGS------CATFDSQNPERADSTVSRDDHIP----GIP-SLTDCLQWFTRPEHLGSSAK 567
Query: 282 VVCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHE 341
+ C++C +Q +T KQL + KLP C HL KR E
Sbjct: 568 IKCNSCQS-------------YQEST--KQLTMKKLPIVACFHL------------KRFE 600
Query: 342 HVQFNEFLMMDIYKYHLLGHKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGAPKTQI 401
HV + K+N LEL
Sbjct: 601 HV--------------------GKQRRKINTFISFPLELD-------------------- 620
Query: 402 FMNGACSPSLLPTLSAPMPFPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPP 461
+P L T + M P D + + L AV+ HHG + SGH+ ++ R
Sbjct: 621 -----MTPFLASTKESRMKEGQPPT-DCVPNENKYSLFAVINHHGTLESGHYTSFIRQQ- 673
Query: 462 SARNPLSTSNQWLWVSDDTVRKASLQEVLSSSAYLLFYER 501
+QW D + KA+++++L S YLLFY +
Sbjct: 674 --------KDQWFSCDDAIITKATIEDLLYSEGYLLFYHK 705
>gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens]
Length = 438
Score = 69.3 bits (168), Expect = 8e-12
Identities = 107/468 (22%), Positives = 169/468 (36%), Gaps = 137/468 (29%)
Query: 69 GLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALS 128
GL+NLGNTCFMN ++Q L+ P L +F + P L + L + L
Sbjct: 79 GLINLGNTCFMNCIVQALTHTPI----LRDFFLSDRHRCEMPSPELCLVCEMSSLFRELY 134
Query: 129 CQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFD 188
+ LL ++ ++ ++ + +QDAHE + L
Sbjct: 135 SGNPSPHVPYK---LLHLVWIHARHLAGYRQQDAHEFL----------------IAALDV 175
Query: 189 VHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTF 248
+H + ++ + + +P + F G L S++ C+ C H D
Sbjct: 176 LHRHCKGDDVG--------KAANNPNHCNCIIDQIFTGGLQSDVTCQAC-HGVSTTIDPC 226
Query: 249 DSLSLSIPAA-TWGHPL------------------TLDHCLHHFISSE---SVRDVVCDN 286
+SL +P + T P+ TL CL F E S + C +
Sbjct: 227 WDISLDLPGSCTSFWPMSPGRESSVNGESHIPGITTLTDCLRRFTRPEHLGSSAKIKCGS 286
Query: 287 CTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFN 346
C +Q +T KQL + KLP C H KR EH
Sbjct: 287 CQS-------------YQEST--KQLTMNKLPVVACFHF------------KRFEH---- 315
Query: 347 EFLMMDIYKYHLLGHKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGAPKTQIFMNGA 406
++ K+ LEL TP + A + MNG
Sbjct: 316 ----------------SAKQRRKITTYISFPLELD-----MTPFM----ASSKESRMNGQ 350
Query: 407 CSPSLLPTLSAPMPFPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNP 466
LPT S ++ + L AVV H G + SGH+ ++ R
Sbjct: 351 LQ---LPTNSG-------------NNENKYSLFAVVNHQGTLESGHYTSFIRHH------ 388
Query: 467 LSTSNQWLWVSDDTVRKASLQEVLSSSAYLLFYERVLSRMQHQSQECK 514
+QW D + KAS+++VL S YLLFY + + ++H+S++ K
Sbjct: 389 ---KDQWFKCDDAVITKASIKDVLDSEGYLLFYHKQV--LEHESEKVK 431
>gi|197116355 ubiquitin specific peptidase 46 isoform 2 [Homo
sapiens]
Length = 359
Score = 67.4 bits (163), Expect = 3e-11
Identities = 69/269 (25%), Positives = 115/269 (42%), Gaps = 51/269 (18%)
Query: 69 GLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALS 128
GLVN GNTC+ NS+LQ L C F E Y QK+ + L L L +++
Sbjct: 29 GLVNFGNTCYCNSVLQALYFCRPF----RENVLAYKAQQKK---KENLLTCLADLFHSIA 81
Query: 129 CQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLED---ERDRQPRVTH 185
Q+ V+ + LR ++ +QDAHE + + +++ D E +Q +
Sbjct: 82 TQK-KKVGVIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQEEKKQEKQNG 140
Query: 186 LFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPVRF 245
++ + +E ++T W + F G LT+ C +CE S
Sbjct: 141 KLKNGNMNEPAENNKPELT-------------WVHE-IFQGTLTNETRCLNCETVSSKDE 186
Query: 246 DTFDSLSLSIPAATWGHPLTLDHCLHHFISSE---SVRDVVCDN-CTKIEAKGTLNGEKV 301
D D LS+ + T ++ HCL F ++E S + C+ C+K EA+
Sbjct: 187 DFLD-LSVDVEQNT-----SITHCLRDFSNTETLCSEQKYYCETCCSKQEAQ-------- 232
Query: 302 EHQRTTFVKQLKLGKLPQCLCIHLQRLSW 330
K++++ KLP L +HL+R +
Sbjct: 233 --------KRMRVKKLPMILALHLKRFKY 253
>gi|31377709 ubiquitin specific peptidase 46 isoform 1 [Homo
sapiens]
Length = 366
Score = 67.4 bits (163), Expect = 3e-11
Identities = 69/269 (25%), Positives = 115/269 (42%), Gaps = 51/269 (18%)
Query: 69 GLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALS 128
GLVN GNTC+ NS+LQ L C F E Y QK+ + L L L +++
Sbjct: 36 GLVNFGNTCYCNSVLQALYFCRPF----RENVLAYKAQQKK---KENLLTCLADLFHSIA 88
Query: 129 CQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLED---ERDRQPRVTH 185
Q+ V+ + LR ++ +QDAHE + + +++ D E +Q +
Sbjct: 89 TQK-KKVGVIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQEEKKQEKQNG 147
Query: 186 LFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPVRF 245
++ + +E ++T W + F G LT+ C +CE S
Sbjct: 148 KLKNGNMNEPAENNKPELT-------------WVHE-IFQGTLTNETRCLNCETVSSKDE 193
Query: 246 DTFDSLSLSIPAATWGHPLTLDHCLHHFISSE---SVRDVVCDN-CTKIEAKGTLNGEKV 301
D D LS+ + T ++ HCL F ++E S + C+ C+K EA+
Sbjct: 194 DFLD-LSVDVEQNT-----SITHCLRDFSNTETLCSEQKYYCETCCSKQEAQ-------- 239
Query: 302 EHQRTTFVKQLKLGKLPQCLCIHLQRLSW 330
K++++ KLP L +HL+R +
Sbjct: 240 --------KRMRVKKLPMILALHLKRFKY 260
>gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens]
Length = 520
Score = 67.4 bits (163), Expect = 3e-11
Identities = 72/282 (25%), Positives = 111/282 (39%), Gaps = 39/282 (13%)
Query: 69 GLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLT--------L 120
GL NLGNTCFMN++LQ LS F + +E + R+ K Y + + +
Sbjct: 160 GLRNLGNTCFMNAILQSLSNIEQFCCYFKELPAVELRNGKTAGRRTYHTRSQGDNNVSLV 219
Query: 121 LHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQ 180
K L L V+ +++QDAHE + L E Q
Sbjct: 220 EEFRKTLCALWQGSQTAFSPESLFYVVWKIMPNFRGYQQQDAHEFMRYLLDHLHLE--LQ 277
Query: 181 PRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQ 240
+ L++ S ++ C S T+ F G L + + C C +
Sbjct: 278 GGFNGVSRSAILQENSTLSASNKCCINGASTVVTA-------IFGGILQNEVNCLICGTE 330
Query: 241 SPVRFDTFDSLSLSIPA---------ATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIE 291
S +FD F LSL IP+ G +L CL F E + + C K +
Sbjct: 331 SR-KFDPFLDLSLDIPSQFRSKRSKNQENGPVCSLRDCLRSFTDLEELDETELYMCHKCK 389
Query: 292 AKGTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSH 333
K Q++T K+ + KLP+ LC+HL+R W+++
Sbjct: 390 KK----------QKST--KKFWIQKLPKVLCLHLKRFHWTAY 419
Score = 41.2 bits (95), Expect = 0.002
Identities = 25/78 (32%), Positives = 39/78 (50%), Gaps = 17/78 (21%)
Query: 435 LFRLMAVVVHHGD-MHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSS 493
L+ L AVVVHHG + SGH+ Y + +W +D TV + V+ +
Sbjct: 453 LYDLAAVVVHHGSGVGSGHYTAYA----------THEGRWFHFNDSTVTLTDEETVVKAK 502
Query: 494 AYLLFYERVLSRMQHQSQ 511
AY+LFY ++HQ++
Sbjct: 503 AYILFY------VEHQAK 514
>gi|32698815 ubiquitin thiolesterase 12 [Homo sapiens]
Length = 370
Score = 67.4 bits (163), Expect = 3e-11
Identities = 73/296 (24%), Positives = 124/296 (41%), Gaps = 48/296 (16%)
Query: 69 GLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALS 128
GLVN GNTC+ NS+LQ L C F + + SQ P + L L L +++
Sbjct: 40 GLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQ-------PRKKESLLTCLADLFHSIA 92
Query: 129 CQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHE----LFHVITSSLEDERDRQPRVT 184
Q+ V+ + LR ++ +QDAHE L + I L++ER ++ +
Sbjct: 93 TQK-KKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNG 151
Query: 185 HLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPVR 244
L + + + + T P PT W + F G LT+ C CE S
Sbjct: 152 RLPNGNIDNENNNST-----------PDPT---WVDE-IFQGTLTNETRCLTCETISSKD 196
Query: 245 FDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEKVEHQ 304
D D LS+ + T ++ HCL F ++E++ C + +K +
Sbjct: 197 EDFLD-LSVDVEQNT-----SITHCLRGFSNTETLCSEYKYYCEECRSKQEAH------- 243
Query: 305 RTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLG 360
K++K+ KLP L +HL+R + L R+ + + +++ ++ G
Sbjct: 244 -----KRMKVKKLPMILALHLKRFKYMDQ---LHRYTKLSYRVVFPLELRLFNTSG 291
>gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo
sapiens]
Length = 605
Score = 63.9 bits (154), Expect = 3e-10
Identities = 78/303 (25%), Positives = 120/303 (39%), Gaps = 45/303 (14%)
Query: 48 GIYVIW--------GPITERKKRRKGL-------VPGLVNLGNTCFMNSLLQGLSACPAF 92
G Y +W GP R G+ + GL NLGNTCFMNS+LQ C +
Sbjct: 232 GRYTLWETGKGQAPGPSRSSSPGRDGMNSKSAQGLAGLRNLGNTCFMNSILQ----CLSN 287
Query: 93 IRWLEEFTSQ--YSRD-QKEPPSHQYLSLTLLHLLKALSCQEVTDDEVLDASCLLDVLRM 149
R L ++ Q Y RD +H L L++ + D V+ S ++
Sbjct: 288 TRELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQTIWTSSPND--VVSPSEFKTQIQR 345
Query: 150 YRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFDVHSLEQQSEITPKQITCRTRG 209
Y + + +QDA E + L +E + RVT S + + P R
Sbjct: 346 YAPRFVGYNQQDAQEFLRFLLDGLHNEVN---RVT--LRPKSNPENLDHLPDDEKGRQMW 400
Query: 210 SPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAATWGHP-LTLDH 268
+ + F G+L S++ C C + S V FD F LS+P A G+P +TL
Sbjct: 401 RKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTV-FDPF--WDLSLPIAKRGYPEVTLMD 457
Query: 269 CLHHFISSESVRDVVCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRL 328
C+ F + + C + R +K+ + + P+ L +HL+R
Sbjct: 458 CMRLFTKEDVLDGDEKPTCCRCRG------------RKRCIKKFSIQRFPKILVLHLKRF 505
Query: 329 SWS 331
S S
Sbjct: 506 SES 508
Score = 43.1 bits (100), Expect = 6e-04
Identities = 24/66 (36%), Positives = 33/66 (50%), Gaps = 8/66 (12%)
Query: 435 LFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSA 494
++ L AV H G GH+ Y RSP + +W +D +V S +V +S A
Sbjct: 540 VYNLYAVSNHSGTTMGGHYTAYCRSPGTG--------EWHTFNDSSVTPMSSSQVRTSDA 591
Query: 495 YLLFYE 500
YLLFYE
Sbjct: 592 YLLFYE 597
>gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens]
Length = 396
Score = 63.5 bits (153), Expect = 4e-10
Identities = 74/278 (26%), Positives = 115/278 (41%), Gaps = 31/278 (11%)
Query: 58 ERKKRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQ--YSRD-QKEPPSHQ 114
+ K +GL GL NLGNTCFMNS+LQ C + R L ++ Q Y RD +H
Sbjct: 49 KNSKSAQGLA-GLRNLGNTCFMNSILQ----CLSNTRELRDYCLQRLYMRDLHHGSNAHT 103
Query: 115 YLSLTLLHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLE 174
L L++ + D V+ S ++ Y + + +QDA E + L
Sbjct: 104 ALVEEFAKLIQTIWTSSPND--VVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLH 161
Query: 175 DERDRQPRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVC 234
+E + RVT S + + P R + + F G+L S++ C
Sbjct: 162 NEVN---RVT--LRPKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTC 216
Query: 235 KHCEHQSPVRFDTFDSLSLSIPAATWGHP-LTLDHCLHHFISSESVRDVVCDNCTKIEAK 293
C + S V FD F LS+P A G+P +TL C+ F + + C +
Sbjct: 217 TDCGYCSTV-FDPF--WDLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRG- 272
Query: 294 GTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWS 331
R +K+ + + P+ L +HL+R S S
Sbjct: 273 -----------RKRCIKKFSIQRFPKILVLHLKRFSES 299
Score = 43.1 bits (100), Expect = 6e-04
Identities = 24/66 (36%), Positives = 33/66 (50%), Gaps = 8/66 (12%)
Query: 435 LFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSA 494
++ L AV H G GH+ Y RSP + +W +D +V S +V +S A
Sbjct: 331 VYNLYAVSNHSGTTMGGHYTAYCRSPGTG--------EWHTFNDSSVTPMSSSQVRTSDA 382
Query: 495 YLLFYE 500
YLLFYE
Sbjct: 383 YLLFYE 388
>gi|62243586 ubiquitin-specific protease 21 [Homo sapiens]
Length = 565
Score = 62.8 bits (151), Expect = 7e-10
Identities = 74/292 (25%), Positives = 119/292 (40%), Gaps = 37/292 (12%)
Query: 69 GLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALS 128
GL NLGNTCF+N++LQ LS+ R L +F + Q+ P + LT +
Sbjct: 213 GLRNLGNTCFLNAVLQCLSST----RPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGA 268
Query: 129 CQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFD 188
E ++ + V + Y S + +QDA E ++ L E +R+ R
Sbjct: 269 LWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPIL 328
Query: 189 VH-----------SLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHC 237
+ +L ++ E++ + K F G+L S + C+ C
Sbjct: 329 ANGPVPSPPRRGGALLEEPELSDDD-RANLMWKRYLEREDSKIVDLFVGQLKSCLKCQAC 387
Query: 238 EHQSPVRFDTFDSLSLSIPAATW-GHPLTLDHCLHHFISSESVRDV---VCDNCTKIEAK 293
++S F+ F LSL IP + G ++L C + F E + VCD C
Sbjct: 388 GYRSTT-FEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRC------ 440
Query: 294 GTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQF 345
Q+T K+L + + P+ L +HL R S +S G+ K V F
Sbjct: 441 ---------RQKTRSTKKLTVQRFPRILVLHLNRFS-ASRGSIKKSSVGVDF 482
Score = 33.9 bits (76), Expect = 0.37
Identities = 19/66 (28%), Positives = 29/66 (43%), Gaps = 10/66 (15%)
Query: 435 LFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSA 494
+++L A+ H G +H GH+ R W +D V S +V SS
Sbjct: 501 VYQLYALCNHSGSVHYGHYTALCRCQTG----------WHVYNDSRVSPVSENQVASSEG 550
Query: 495 YLLFYE 500
Y+LFY+
Sbjct: 551 YVLFYQ 556
>gi|74027267 ubiquitin-specific protease 21 [Homo sapiens]
Length = 565
Score = 62.8 bits (151), Expect = 7e-10
Identities = 74/292 (25%), Positives = 119/292 (40%), Gaps = 37/292 (12%)
Query: 69 GLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALS 128
GL NLGNTCF+N++LQ LS+ R L +F + Q+ P + LT +
Sbjct: 213 GLRNLGNTCFLNAVLQCLSST----RPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGA 268
Query: 129 CQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFD 188
E ++ + V + Y S + +QDA E ++ L E +R+ R
Sbjct: 269 LWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPIL 328
Query: 189 VH-----------SLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHC 237
+ +L ++ E++ + K F G+L S + C+ C
Sbjct: 329 ANGPVPSPPRRGGALLEEPELSDDD-RANLMWKRYLEREDSKIVDLFVGQLKSCLKCQAC 387
Query: 238 EHQSPVRFDTFDSLSLSIPAATW-GHPLTLDHCLHHFISSESVRDV---VCDNCTKIEAK 293
++S F+ F LSL IP + G ++L C + F E + VCD C
Sbjct: 388 GYRSTT-FEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRC------ 440
Query: 294 GTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQF 345
Q+T K+L + + P+ L +HL R S +S G+ K V F
Sbjct: 441 ---------RQKTRSTKKLTVQRFPRILVLHLNRFS-ASRGSIKKSSVGVDF 482
Score = 33.9 bits (76), Expect = 0.37
Identities = 19/66 (28%), Positives = 29/66 (43%), Gaps = 10/66 (15%)
Query: 435 LFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSA 494
+++L A+ H G +H GH+ R W +D V S +V SS
Sbjct: 501 VYQLYALCNHSGSVHYGHYTALCRCQTG----------WHVYNDSRVSPVSENQVASSEG 550
Query: 495 YLLFYE 500
Y+LFY+
Sbjct: 551 YVLFYQ 556
>gi|109134334 ubiquitin thiolesterase 44 [Homo sapiens]
Length = 712
Score = 60.5 bits (145), Expect = 4e-09
Identities = 89/354 (25%), Positives = 130/354 (36%), Gaps = 73/354 (20%)
Query: 61 KRRKGLVPGLV---NLGNTCFMNSLLQGLSACPAFIR---------WLEEFTSQYSRDQK 108
KRR + PG+ NLGNTC+MNS+LQ LS F + WL S+ +R K
Sbjct: 263 KRRPIVTPGVTGLRNLGNTCYMNSVLQVLSHLLIFRQCFLKLDLNQWLAMTASEKTRSCK 322
Query: 109 EPPSHQYLSLTLLHLLKALSCQEVTDDEVLDASCLLD------VLRMYRWQISSFEE--- 159
H ++ T+++ + CQE V L + + ++ +E
Sbjct: 323 ----HPPVTDTVVYQMN--ECQEKDTGFVCSRQSSLSSGLSGGASKGRKMELIQPKEPTS 376
Query: 160 ------QDAHELFHVITSSL----------------------EDERDRQPRVTHLFDV-- 189
+ H LF V+ S ++D Q + L D
Sbjct: 377 QYISLCHELHTLFQVMWSGKWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKIQ 436
Query: 190 HSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFD 249
LE P I R N + FHG+L S + C C+++S + F
Sbjct: 437 RELETTGTSLPALIPTSQRKLIKQVLN--VVNNIFHGQLLSQVTCLACDNKSNT-IEPFW 493
Query: 250 SLSLSIPAATW-------GHPLTLDHCLHHFISSESVRD--VVCDNCTKIEAKGTLNGEK 300
LSL P P + L F +E++ VCD C + +
Sbjct: 494 DLSLEFPERYQCSGKDIASQPCLVTEMLAKFTETEALEGKIYVCDQCNSKRRRFSSKPVV 553
Query: 301 VEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIY 354
+ T KQL + LPQ L +HL+R WS K HV F E L M+ Y
Sbjct: 554 L----TEAQKQLMICHLPQVLRLHLKRFRWSGRNNREKIGVHVGFEEILNMEPY 603
Score = 40.4 bits (93), Expect = 0.004
Identities = 22/76 (28%), Positives = 38/76 (50%), Gaps = 9/76 (11%)
Query: 434 YLFRLMAVVVHHGD-MHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSS 492
+++ L AVV+HHG SGH+ Y + S W+ +D + ++ EV +
Sbjct: 617 FIYDLSAVVMHHGKGFGSGHYTAYCYN--------SEGGFWVHCNDSKLSMCTMDEVCKA 668
Query: 493 SAYLLFYERVLSRMQH 508
AY+LFY + ++ H
Sbjct: 669 QAYILFYTQRVTENGH 684
>gi|109134332 ubiquitin thiolesterase 44 [Homo sapiens]
Length = 712
Score = 60.5 bits (145), Expect = 4e-09
Identities = 89/354 (25%), Positives = 130/354 (36%), Gaps = 73/354 (20%)
Query: 61 KRRKGLVPGLV---NLGNTCFMNSLLQGLSACPAFIR---------WLEEFTSQYSRDQK 108
KRR + PG+ NLGNTC+MNS+LQ LS F + WL S+ +R K
Sbjct: 263 KRRPIVTPGVTGLRNLGNTCYMNSVLQVLSHLLIFRQCFLKLDLNQWLAMTASEKTRSCK 322
Query: 109 EPPSHQYLSLTLLHLLKALSCQEVTDDEVLDASCLLD------VLRMYRWQISSFEE--- 159
H ++ T+++ + CQE V L + + ++ +E
Sbjct: 323 ----HPPVTDTVVYQMN--ECQEKDTGFVCSRQSSLSSGLSGGASKGRKMELIQPKEPTS 376
Query: 160 ------QDAHELFHVITSSL----------------------EDERDRQPRVTHLFDV-- 189
+ H LF V+ S ++D Q + L D
Sbjct: 377 QYISLCHELHTLFQVMWSGKWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKIQ 436
Query: 190 HSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFD 249
LE P I R N + FHG+L S + C C+++S + F
Sbjct: 437 RELETTGTSLPALIPTSQRKLIKQVLN--VVNNIFHGQLLSQVTCLACDNKSNT-IEPFW 493
Query: 250 SLSLSIPAATW-------GHPLTLDHCLHHFISSESVRD--VVCDNCTKIEAKGTLNGEK 300
LSL P P + L F +E++ VCD C + +
Sbjct: 494 DLSLEFPERYQCSGKDIASQPCLVTEMLAKFTETEALEGKIYVCDQCNSKRRRFSSKPVV 553
Query: 301 VEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIY 354
+ T KQL + LPQ L +HL+R WS K HV F E L M+ Y
Sbjct: 554 L----TEAQKQLMICHLPQVLRLHLKRFRWSGRNNREKIGVHVGFEEILNMEPY 603
Score = 40.4 bits (93), Expect = 0.004
Identities = 22/76 (28%), Positives = 38/76 (50%), Gaps = 9/76 (11%)
Query: 434 YLFRLMAVVVHHGD-MHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSS 492
+++ L AVV+HHG SGH+ Y + S W+ +D + ++ EV +
Sbjct: 617 FIYDLSAVVMHHGKGFGSGHYTAYCYN--------SEGGFWVHCNDSKLSMCTMDEVCKA 668
Query: 493 SAYLLFYERVLSRMQH 508
AY+LFY + ++ H
Sbjct: 669 QAYILFYTQRVTENGH 684
>gi|22550104 ubiquitin specific protease 32 [Homo sapiens]
Length = 1604
Score = 57.8 bits (138), Expect = 2e-08
Identities = 55/199 (27%), Positives = 84/199 (42%), Gaps = 18/199 (9%)
Query: 69 GLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALS 128
GL NLGNTCFMNS +Q +S ++ Y ++ P + H+ K
Sbjct: 735 GLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKG------HMAKCYG 788
Query: 129 --CQEV---TDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRV 183
QE+ T V L + Y + + F++QD+ EL + L ++ +R
Sbjct: 789 DLVQELWSGTQKNVAPLK-LRWTIAKYAPRFNGFQQQDSQELLAFLLDGLHEDLNRVHEK 847
Query: 184 THLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPV 243
++ + S+ P H N FHG+L S + CK C H S V
Sbjct: 848 PYV-----ELKDSDGRPDWEVAAEAWDNHLRRNRSIVVDLFHGQLRSQVKCKTCGHIS-V 901
Query: 244 RFDTFDSLSLSIPAATWGH 262
RFD F+ LSL +P ++ H
Sbjct: 902 RFDPFNFLSLPLPMDSYMH 920
Score = 43.1 bits (100), Expect = 6e-04
Identities = 20/67 (29%), Positives = 37/67 (55%), Gaps = 9/67 (13%)
Query: 435 LFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSA 494
++ L A+ H G + GH+VTY ++P + +W +D + ++ E+ + SA
Sbjct: 1509 IYNLYAISCHSGILGGGHYVTYAKNP---------NCKWYCYNDSSCKELHPDEIDTDSA 1559
Query: 495 YLLFYER 501
Y+LFYE+
Sbjct: 1560 YILFYEQ 1566
Score = 32.7 bits (73), Expect = 0.82
Identities = 26/83 (31%), Positives = 39/83 (46%), Gaps = 13/83 (15%)
Query: 263 PLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLC 322
P+ LD CL F S E + + C+K + H T K+L L +LP L
Sbjct: 1232 PINLDSCLRAFTSEEELGENEMYYCSKCKT----------HCLAT--KKLDLWRLPPILI 1279
Query: 323 IHLQRLSWSSHGTPLKRHEHVQF 345
IHL+R + +G +K + V+F
Sbjct: 1280 IHLKRFQF-VNGRWIKSQKIVKF 1301
>gi|122937412 ubiquitin specific peptidase 45 [Homo sapiens]
Length = 814
Score = 57.0 bits (136), Expect = 4e-08
Identities = 53/216 (24%), Positives = 90/216 (41%), Gaps = 17/216 (7%)
Query: 61 KRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTL 120
K R V G+ NLGNTCF N+++Q L+ + E ++ + P S L +
Sbjct: 183 KCRNLSVRGITNLGNTCFFNAVMQNLAQTYTLTDLMNEIKESSTKLKIFPSSDSQLDPLV 242
Query: 121 LHLLKA----------LSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVIT 170
+ L + L + T+ L L + L + F++QD+ EL H +
Sbjct: 243 VELSRPGPLTSALFLFLHSMKETEKGPLSPKVLFNQLCQKAPRFKDFQQQDSQELLHYLL 302
Query: 171 SSLEDERDR--QPRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRL 228
++ E + Q + F+ + + + T K++ + G N F G L
Sbjct: 303 DAVRTEETKRIQASILKAFNNPTTKTADDETRKKV--KAYGKEGVKMNF--IDRIFIGEL 358
Query: 229 TSNMVCKHCEHQSPVRFDTFDSLSLSIPAATWGHPL 264
TS ++C+ C + S V+ D F +SL I PL
Sbjct: 359 TSTVMCEECANISTVK-DPFIDISLPIIEERVSKPL 393
Score = 45.4 bits (106), Expect = 1e-04
Identities = 30/87 (34%), Positives = 39/87 (44%), Gaps = 19/87 (21%)
Query: 435 LFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSN------------------QWLWV 476
L+ L +V H G M GH+ Y + +R LS N QW+ V
Sbjct: 729 LYGLYGIVEHSGSMREGHYTAYVKVRTPSRK-LSEHNTKKKNVPGLKAADNESAGQWVHV 787
Query: 477 SDDTVRKASLQEVLSSSAYLLFYERVL 503
SD ++ LS+ AYLLFYERVL
Sbjct: 788 SDTYLQVVPESRALSAQAYLLFYERVL 814
Score = 45.1 bits (105), Expect = 2e-04
Identities = 43/136 (31%), Positives = 66/136 (48%), Gaps = 20/136 (14%)
Query: 230 SNMVC----KHCEHQSPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESV---RDV 282
SN +C KH SP + F +LS S T ++ CL+ F S E + +
Sbjct: 584 SNNLCFLEGKHLRSYSPQ--NAFQTLSQSY--ITTSKECSIQSCLYQFTSMELLMGNNKL 639
Query: 283 VCDNCTKIEAK----GTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLK 338
+C+NCTK + K + +KVE T KQL + +P L +HL+R + G L+
Sbjct: 640 LCENCTKNKQKYQEETSFAEKKVEGVYTNARKQLLISAVPAVLILHLKR--FHQAGLSLR 697
Query: 339 R-HEHVQFNEFLMMDI 353
+ + HV F LM+D+
Sbjct: 698 KVNRHVDFP--LMLDL 711
>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
Length = 1406
Score = 56.2 bits (134), Expect = 7e-08
Identities = 54/193 (27%), Positives = 80/193 (41%), Gaps = 18/193 (9%)
Query: 69 GLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALS 128
GL NLGNTCFMNS +Q +S ++ Y ++ P + H+ K
Sbjct: 533 GLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKG------HMAKCYG 586
Query: 129 --CQEV---TDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRV 183
QE+ T V L + Y + F++QD+ EL + L ++ +R
Sbjct: 587 DLVQELWSGTQKSVAPLK-LRRTIAKYAPKFDGFQQQDSQELLAFLLDGLHEDLNRVHEK 645
Query: 184 THLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPV 243
++ + S+ P H N FHG+L S + CK C H S V
Sbjct: 646 PYV-----ELKDSDGRPDWEVAAEAWDNHLRRNRSIIVDLFHGQLRSQVKCKTCGHIS-V 699
Query: 244 RFDTFDSLSLSIP 256
RFD F+ LSL +P
Sbjct: 700 RFDPFNFLSLPLP 712
Score = 42.4 bits (98), Expect = 0.001
Identities = 19/67 (28%), Positives = 36/67 (53%), Gaps = 9/67 (13%)
Query: 435 LFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSA 494
++ L A+ H G + GH++TY ++P + +W +D + + E+ + SA
Sbjct: 1311 IYNLYAISCHSGILSGGHYITYAKNP---------NCKWYCYNDSSCEELHPDEIDTDSA 1361
Query: 495 YLLFYER 501
Y+LFYE+
Sbjct: 1362 YILFYEQ 1368
Score = 31.6 bits (70), Expect = 1.8
Identities = 22/68 (32%), Positives = 31/68 (45%), Gaps = 12/68 (17%)
Query: 263 PLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLC 322
P+ LD CL F S E + + C+K + H T K+L L +LP L
Sbjct: 1030 PINLDSCLRAFTSEEELGESEMYYCSKCKT----------HCLAT--KKLDLWRLPPFLI 1077
Query: 323 IHLQRLSW 330
IHL+R +
Sbjct: 1078 IHLKRFQF 1085
>gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens]
Length = 963
Score = 55.5 bits (132), Expect = 1e-07
Identities = 52/190 (27%), Positives = 81/190 (42%), Gaps = 12/190 (6%)
Query: 69 GLVNLGNTCFMNSLLQGLSACPAFIRWL--EEFTSQYSRDQKEPPSHQYLSLTLLHLLKA 126
GL NLGNTCFMNS LQ LS + +E+ ++ +RD + ++ L+K
Sbjct: 303 GLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGE-IAEAYAELIKQ 361
Query: 127 LSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHL 186
+ D V V R + Q S +++QD+ EL + L ++ +R + +L
Sbjct: 362 MWSGR--DAHVAPRMFKTQVGR-FAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYL 418
Query: 187 FDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPVRFD 246
+ + P + + H N FHG S +VC C S V FD
Sbjct: 419 E-----LKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVS-VTFD 472
Query: 247 TFDSLSLSIP 256
F L+L +P
Sbjct: 473 PFCYLTLPLP 482
Score = 48.5 bits (114), Expect = 1e-05
Identities = 26/76 (34%), Positives = 44/76 (57%), Gaps = 8/76 (10%)
Query: 426 VPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKAS 485
V + S+ Y++ L+AV H+G M GH+ Y A+N L+ +W + D V AS
Sbjct: 855 VCNLSARPYVYDLIAVSNHYGAMGVGHYTAY------AKNKLN--GKWYYFDDSNVSLAS 906
Query: 486 LQEVLSSSAYLLFYER 501
++++ +AY+LFY+R
Sbjct: 907 EDQIVTKAAYVLFYQR 922
>gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens]
Length = 916
Score = 55.5 bits (132), Expect = 1e-07
Identities = 52/190 (27%), Positives = 81/190 (42%), Gaps = 12/190 (6%)
Query: 69 GLVNLGNTCFMNSLLQGLSACPAFIRWL--EEFTSQYSRDQKEPPSHQYLSLTLLHLLKA 126
GL NLGNTCFMNS LQ LS + +E+ ++ +RD + ++ L+K
Sbjct: 256 GLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGE-IAEAYAELIKQ 314
Query: 127 LSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHL 186
+ D V V R + Q S +++QD+ EL + L ++ +R + +L
Sbjct: 315 MWSGR--DAHVAPRMFKTQVGR-FAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYL 371
Query: 187 FDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPVRFD 246
+ + P + + H N FHG S +VC C S V FD
Sbjct: 372 E-----LKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVS-VTFD 425
Query: 247 TFDSLSLSIP 256
F L+L +P
Sbjct: 426 PFCYLTLPLP 435
Score = 48.5 bits (114), Expect = 1e-05
Identities = 26/76 (34%), Positives = 44/76 (57%), Gaps = 8/76 (10%)
Query: 426 VPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKAS 485
V + S+ Y++ L+AV H+G M GH+ Y A+N L+ +W + D V AS
Sbjct: 808 VCNLSARPYVYDLIAVSNHYGAMGVGHYTAY------AKNKLN--GKWYYFDDSNVSLAS 859
Query: 486 LQEVLSSSAYLLFYER 501
++++ +AY+LFY+R
Sbjct: 860 EDQIVTKAAYVLFYQR 875
>gi|188497648 ubiquitin specific peptidase 37 [Homo sapiens]
Length = 979
Score = 55.1 bits (131), Expect = 2e-07
Identities = 66/285 (23%), Positives = 117/285 (41%), Gaps = 40/285 (14%)
Query: 50 YVIWG-PITERKKRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQK 108
Y W P ++ + G NLGNTC+MN++LQ L + +F L + K
Sbjct: 322 YTGWNKPRVPLSSHQQQQLQGFSNLGNTCYMNAILQSLFSLQSFANDL----LKQGIPWK 377
Query: 109 EPPSHQYLSLTLLHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHV 168
+ P + + L+K C T ++L + + + + S + + DAHE
Sbjct: 378 KIPLNALIRRFAHLLVKKDICNSETKKDLLKK--VKNAISATAERFSGYMQNDAHEFLSQ 435
Query: 169 ITSSLEDERDRQPRVTHLFDVHSLEQQSEIT-PKQITCRTRGSPHPTSNHWKSQHPFHGR 227
L+++ ++ + V E +I+ + TC P T+ ++ QH
Sbjct: 436 CLDQLKEDMEKLNKTWKTEPVSGEENSPDISATRAYTC-----PVITNLEFEVQH----- 485
Query: 228 LTSNMVCKHCEHQSPVRFDTFDSLSLSIPAATWG-HPLTLDHCLHHFISSESVRDVVCDN 286
+++CK C P R + F+ LS+ +P P ++ L F +E + +
Sbjct: 486 ---SIICKACGEIIPKR-EQFNDLSIDLPRRKKPLPPRSIQDSLDLFFRAEELE----YS 537
Query: 287 CTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWS 331
C K K L V H K +LP+ L +HL+R S++
Sbjct: 538 CEKCGGKCAL----VRH---------KFNRLPRVLILHLKRYSFN 569
>gi|13994268 ubiquitin-specific protease 26 [Homo sapiens]
Length = 913
Score = 54.7 bits (130), Expect = 2e-07
Identities = 70/287 (24%), Positives = 119/287 (41%), Gaps = 43/287 (14%)
Query: 69 GLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALS 128
GL NLGNTC+MN++LQ L + P+F ++ +Q K P + L++ L LL
Sbjct: 296 GLPNLGNTCYMNAVLQSLLSIPSF---ADDLLNQSFPWGKIPLN--ALTMCLARLLFFKD 350
Query: 129 CQEVTDDEVLDASCLLDVLRMYRWQISSFE---EQDAHELFHVITSSLEDERDRQPRVTH 185
+ E+L LL++ + F + DAHE + L+ +D ++
Sbjct: 351 TYNIEIKEML----LLNLKKAISAAAEIFHGNAQNDAHEF---LAHCLDQLKDNMEKLNT 403
Query: 186 LFDVHSLEQQSEITPKQITC---RTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSP 242
++ S E + PKQ+ T G P + F L ++ CK C Q
Sbjct: 404 IWKPKS-EFGEDNFPKQVFADDPDTSGFSCPVITN------FELELLHSIACKAC-GQVI 455
Query: 243 VRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEKVE 302
++ + + LS+++P HP ++ F +E + C K E K
Sbjct: 456 LKTELNNYLSINLPQRIKAHPSSIQSTFDLFFGAEELE----YKCAKCEHK--------- 502
Query: 303 HQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFL 349
T V +LP+ L +HL+R S + K + V +++L
Sbjct: 503 ----TSVGVHSFSRLPRILIVHLKRYSLNEFCALKKNDQEVIISKYL 545
>gi|120587027 ubiquitin specific peptidase 31 [Homo sapiens]
Length = 1352
Score = 54.3 bits (129), Expect = 3e-07
Identities = 53/203 (26%), Positives = 81/203 (39%), Gaps = 29/203 (14%)
Query: 67 VPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQ----------YL 116
V GL N GNTCFMN+ LQ LS F +L + R + P Q +
Sbjct: 127 VAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQYRAGRPEPSPDPEQPAGRGAQGQGEV 186
Query: 117 SLTLLHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDE 176
+ L HL++AL E T D ++ + Q + DA E + + ++
Sbjct: 187 TEQLAHLVRALWTLEYTPQHSRDFKTIVSKNAL---QYRGNSQHDAQEFLLWLLDRVHED 243
Query: 177 RDRQPRVTHLFDVHSLEQQSE---ITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMV 233
+ HS++Q + P + G P + + Q F + S++
Sbjct: 244 LN-----------HSVKQSGQPPLKPPSETDMMPEGPSFPVCSTF-VQELFQAQYRSSLT 291
Query: 234 CKHCEHQSPVRFDTFDSLSLSIP 256
C HC+ QS FD F +SL IP
Sbjct: 292 CPHCQKQSNT-FDPFLCISLPIP 313
Score = 48.9 bits (115), Expect = 1e-05
Identities = 24/68 (35%), Positives = 35/68 (51%), Gaps = 8/68 (11%)
Query: 434 YLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSS 493
Y++ L AV HHG M GH+ Y ++ S W D V++ S EV + +
Sbjct: 705 YIYDLYAVCNHHGTMQGGHYTAYCKN--------SVDGLWYCFDDSDVQQLSEDEVCTQT 756
Query: 494 AYLLFYER 501
AY+LFY+R
Sbjct: 757 AYILFYQR 764
>gi|21361749 ubiquitin thioesterase 49 [Homo sapiens]
Length = 640
Score = 53.1 bits (126), Expect = 6e-07
Identities = 45/145 (31%), Positives = 61/145 (42%), Gaps = 21/145 (14%)
Query: 224 FHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAATWGH-------PLTLDHCL-----H 271
FHG+L S + C C ++S + F LSL P H PL CL
Sbjct: 445 FHGQLLSQVTCISCNYKSNT-IEPFWDLSLEFPERY--HCIEKGFVPLNQTECLLTEMLA 501
Query: 272 HFISSESV--RDVVCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLS 329
F +E++ R CD C K + R KQL + +LPQ L +HL+R
Sbjct: 502 KFTETEALEGRIYACDQCNSKRRKSNPKPLVLSEAR----KQLMIYRLPQVLRLHLKRFR 557
Query: 330 WSSHGTPLKRHEHVQFNEFLMMDIY 354
WS K HV F++ L M+ Y
Sbjct: 558 WSGRNHREKIGVHVVFDQVLTMEPY 582
Score = 36.2 bits (82), Expect = 0.074
Identities = 18/39 (46%), Positives = 25/39 (64%), Gaps = 3/39 (7%)
Query: 57 TERKKRRKGLVPGLV---NLGNTCFMNSLLQGLSACPAF 92
T + +R+ + PG+ NLGNTC+MNS+LQ LS F
Sbjct: 239 TLKLRRQPAMAPGVTGLRNLGNTCYMNSILQVLSHLQKF 277
>gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens]
Length = 952
Score = 52.4 bits (124), Expect = 1e-06
Identities = 49/199 (24%), Positives = 82/199 (41%), Gaps = 11/199 (5%)
Query: 59 RKKRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQ-YLS 117
R + GL GL NLGNTCFMNS +Q LS P + Q + P + ++
Sbjct: 252 RNNEQPGLC-GLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIA 310
Query: 118 LTLLHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDER 177
+ L+K + + + + + + Q S +++QD EL + L ++
Sbjct: 311 KSYAELIKQMWSGKFS---YVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDL 367
Query: 178 DRQPRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHC 237
+R + ++ + ++ P ++ H N FHG S +VC C
Sbjct: 368 NRIRKKPYI-----QLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPEC 422
Query: 238 EHQSPVRFDTFDSLSLSIP 256
S V FD F L+L +P
Sbjct: 423 AKIS-VTFDPFCYLTLPLP 440
Score = 44.7 bits (104), Expect = 2e-04
Identities = 20/66 (30%), Positives = 36/66 (54%), Gaps = 8/66 (12%)
Query: 436 FRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSAY 495
+ L+AV H+G M GH+ + ++ + W + D +V AS +++S +AY
Sbjct: 846 YNLIAVSNHYGGMGGGHYTAFAKNKDDGK--------WYYFDDSSVSTASEDQIVSKAAY 897
Query: 496 LLFYER 501
+LFY+R
Sbjct: 898 VLFYQR 903
Score = 30.0 bits (66), Expect = 5.3
Identities = 15/32 (46%), Positives = 21/32 (65%), Gaps = 2/32 (6%)
Query: 302 EHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSH 333
EHQ+ T K+L L LP L +HL+R S+S +
Sbjct: 785 EHQQAT--KKLDLWSLPPVLVVHLKRFSYSRY 814
>gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens]
Length = 822
Score = 52.0 bits (123), Expect = 1e-06
Identities = 28/83 (33%), Positives = 41/83 (49%), Gaps = 14/83 (16%)
Query: 435 LFRLMAVVVHHGDMHSGHFVTYRRSPPSARN--------------PLSTSNQWLWVSDDT 480
L+ L VV H G M SGH+ Y ++ + + + + QW +SD
Sbjct: 740 LYSLYGVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTH 799
Query: 481 VRKASLQEVLSSSAYLLFYERVL 503
V+ +VL+S AYLLFYER+L
Sbjct: 800 VQAVPTTKVLNSQAYLLFYERIL 822
Score = 48.1 bits (113), Expect = 2e-05
Identities = 61/261 (23%), Positives = 104/261 (39%), Gaps = 21/261 (8%)
Query: 67 VPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLT------- 119
V GL NLGNTCF N+++Q LS P L+E + + EPP L+LT
Sbjct: 194 VKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPD---LALTEPLEINL 250
Query: 120 ------LLHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSL 173
L + + L+ + T V+ L + + +++QD+ EL + +
Sbjct: 251 EPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGM 310
Query: 174 EDERDRQPRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMV 233
E + RV+ + + +E +++ + + S F G LTS ++
Sbjct: 311 RAEEHQ--RVSKGI-LKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELTSMIM 367
Query: 234 CKHCEHQSPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESV-RDVVCDNCTKIEA 292
C C S V ++F LSL + G D L + E + DN + I+
Sbjct: 368 CDQCRTVSLVH-ESFLDLSLPVLDDQSGKKSVNDKNLKKTVEDEDQDSEEEKDNDSYIKE 426
Query: 293 KGTLNGEKVEHQRTTFVKQLK 313
+ + +H + KQ K
Sbjct: 427 RSDIPSGTSKHLQKKAKKQAK 447
Score = 46.6 bits (109), Expect = 5e-05
Identities = 27/91 (29%), Positives = 49/91 (53%), Gaps = 8/91 (8%)
Query: 265 TLDHCLHHFISSESVRD---VVCDNCTKIEAKG---TLNGEKVEHQRTTFVKQLKLGKLP 318
++ HCL+ F +E +RD ++C+ CT+ + G + GE+ +H T KQ+ + P
Sbjct: 631 SIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGER-KHVYTNAKKQMLISLAP 689
Query: 319 QCLCIHLQRLSWSSHGTPLKRHEHVQFNEFL 349
L +HL+R + K ++H++F E L
Sbjct: 690 PVLTLHLKRFQQAGFNL-RKVNKHIKFPEIL 719
>gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens]
Length = 823
Score = 52.0 bits (123), Expect = 1e-06
Identities = 28/83 (33%), Positives = 41/83 (49%), Gaps = 14/83 (16%)
Query: 435 LFRLMAVVVHHGDMHSGHFVTYRRSPPSARN--------------PLSTSNQWLWVSDDT 480
L+ L VV H G M SGH+ Y ++ + + + + QW +SD
Sbjct: 741 LYSLYGVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTH 800
Query: 481 VRKASLQEVLSSSAYLLFYERVL 503
V+ +VL+S AYLLFYER+L
Sbjct: 801 VQAVPTTKVLNSQAYLLFYERIL 823
Score = 48.1 bits (113), Expect = 2e-05
Identities = 61/261 (23%), Positives = 104/261 (39%), Gaps = 21/261 (8%)
Query: 67 VPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLT------- 119
V GL NLGNTCF N+++Q LS P L+E + + EPP L+LT
Sbjct: 195 VKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPD---LALTEPLEINL 251
Query: 120 ------LLHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSL 173
L + + L+ + T V+ L + + +++QD+ EL + +
Sbjct: 252 EPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGM 311
Query: 174 EDERDRQPRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMV 233
E + RV+ + + +E +++ + + S F G LTS ++
Sbjct: 312 RAEEHQ--RVSKGI-LKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELTSMIM 368
Query: 234 CKHCEHQSPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESV-RDVVCDNCTKIEA 292
C C S V ++F LSL + G D L + E + DN + I+
Sbjct: 369 CDQCRTVSLVH-ESFLDLSLPVLDDQSGKKSVNDKNLKKTVEDEDQDSEEEKDNDSYIKE 427
Query: 293 KGTLNGEKVEHQRTTFVKQLK 313
+ + +H + KQ K
Sbjct: 428 RSDIPSGTSKHLQKKAKKQAK 448
Score = 46.6 bits (109), Expect = 5e-05
Identities = 27/91 (29%), Positives = 49/91 (53%), Gaps = 8/91 (8%)
Query: 265 TLDHCLHHFISSESVRD---VVCDNCTKIEAKG---TLNGEKVEHQRTTFVKQLKLGKLP 318
++ HCL+ F +E +RD ++C+ CT+ + G + GE+ +H T KQ+ + P
Sbjct: 632 SIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGER-KHVYTNAKKQMLISLAP 690
Query: 319 QCLCIHLQRLSWSSHGTPLKRHEHVQFNEFL 349
L +HL+R + K ++H++F E L
Sbjct: 691 PVLTLHLKRFQQAGFNL-RKVNKHIKFPEIL 720
>gi|75992941 ubiquitin specific protease 16 isoform a [Homo sapiens]
Length = 823
Score = 52.0 bits (123), Expect = 1e-06
Identities = 28/83 (33%), Positives = 41/83 (49%), Gaps = 14/83 (16%)
Query: 435 LFRLMAVVVHHGDMHSGHFVTYRRSPPSARN--------------PLSTSNQWLWVSDDT 480
L+ L VV H G M SGH+ Y ++ + + + + QW +SD
Sbjct: 741 LYSLYGVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTH 800
Query: 481 VRKASLQEVLSSSAYLLFYERVL 503
V+ +VL+S AYLLFYER+L
Sbjct: 801 VQAVPTTKVLNSQAYLLFYERIL 823
Score = 48.1 bits (113), Expect = 2e-05
Identities = 61/261 (23%), Positives = 104/261 (39%), Gaps = 21/261 (8%)
Query: 67 VPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLT------- 119
V GL NLGNTCF N+++Q LS P L+E + + EPP L+LT
Sbjct: 195 VKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPD---LALTEPLEINL 251
Query: 120 ------LLHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSL 173
L + + L+ + T V+ L + + +++QD+ EL + +
Sbjct: 252 EPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGM 311
Query: 174 EDERDRQPRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMV 233
E + RV+ + + +E +++ + + S F G LTS ++
Sbjct: 312 RAEEHQ--RVSKGI-LKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELTSMIM 368
Query: 234 CKHCEHQSPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESV-RDVVCDNCTKIEA 292
C C S V ++F LSL + G D L + E + DN + I+
Sbjct: 369 CDQCRTVSLVH-ESFLDLSLPVLDDQSGKKSVNDKNLKKTVEDEDQDSEEEKDNDSYIKE 427
Query: 293 KGTLNGEKVEHQRTTFVKQLK 313
+ + +H + KQ K
Sbjct: 428 RSDIPSGTSKHLQKKAKKQAK 448
Score = 46.6 bits (109), Expect = 5e-05
Identities = 27/91 (29%), Positives = 49/91 (53%), Gaps = 8/91 (8%)
Query: 265 TLDHCLHHFISSESVRD---VVCDNCTKIEAKG---TLNGEKVEHQRTTFVKQLKLGKLP 318
++ HCL+ F +E +RD ++C+ CT+ + G + GE+ +H T KQ+ + P
Sbjct: 632 SIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGER-KHVYTNAKKQMLISLAP 690
Query: 319 QCLCIHLQRLSWSSHGTPLKRHEHVQFNEFL 349
L +HL+R + K ++H++F E L
Sbjct: 691 PVLTLHLKRFQQAGFNL-RKVNKHIKFPEIL 720
>gi|24234683 ubiquitin specific peptidase 11 [Homo sapiens]
Length = 963
Score = 52.0 bits (123), Expect = 1e-06
Identities = 57/221 (25%), Positives = 88/221 (39%), Gaps = 26/221 (11%)
Query: 46 AAGIYVIWGPITERKKRRKGL--VPGLVNLGNTCFMNSLLQGLSACPAFIR------WLE 97
+A ++V+ ++E + KG + GL NLGNTCFMNS LQ LS P +LE
Sbjct: 285 SAQLHVMNNNMSEEDEDFKGQPGICGLTNLGNTCFMNSALQCLSNVPQLTEYFLNNCYLE 344
Query: 98 EFTSQYSRDQKEPPSHQYLSLTLLHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSF 157
E + K + Y L + +A S + + + + Q +
Sbjct: 345 ELNFRNPLGMKGEIAEAYADL----VKQAWSGHH----RSIVPHVFKNKVGHFASQFLGY 396
Query: 158 EEQDAHELFHVITSSLEDE--RDRQPRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTS 215
++ D+ EL + L ++ R ++ L D P Q + H
Sbjct: 397 QQHDSQELLSFLLDGLHEDLNRVKKKEYVELCDAAG-------RPDQEVAQEAWQNHKRR 449
Query: 216 NHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIP 256
N FHG S +VC C + S V FD F LS+ +P
Sbjct: 450 NDSVIVDTFHGLFKSTLVCPDCGNVS-VTFDPFCYLSVPLP 489
Score = 45.1 bits (105), Expect = 2e-04
Identities = 22/68 (32%), Positives = 37/68 (54%), Gaps = 8/68 (11%)
Query: 434 YLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSS 493
Y + L+AV H+G M GH+ T+ + S QW + D++V + ++ S +
Sbjct: 870 YKYDLIAVSNHYGGMRDGHYTTFACN--------KDSGQWHYFDDNSVSPVNENQIESKA 921
Query: 494 AYLLFYER 501
AY+LFY+R
Sbjct: 922 AYVLFYQR 929
Score = 33.1 bits (74), Expect = 0.63
Identities = 30/113 (26%), Positives = 48/113 (42%), Gaps = 22/113 (19%)
Query: 263 PLTLDHCLHHFISSESVRDV---VCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQ 319
P+ L C+ F + E++ C +C +HQ T K+L L LP+
Sbjct: 778 PVRLQECIELFTTVETLEKENPWYCPSCK-------------QHQLAT--KKLDLWMLPE 822
Query: 320 CLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLGHKPSQHNPKLNK 372
L IHL+R S+ T R + EF + D+ + ++ NP+L K
Sbjct: 823 ILIIHLKRFSY----TKFSREKLDTLVEFPIRDLDFSEFVIQPQNESNPELYK 871
>gi|57529246 ubiquitin thioesterase 19 [Homo sapiens]
Length = 1318
Score = 50.4 bits (119), Expect = 4e-06
Identities = 50/203 (24%), Positives = 83/203 (40%), Gaps = 13/203 (6%)
Query: 58 ERKKRRKGLVPG---LVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEP-PSH 113
E ++ +K +PG LVNLGNTCFMNS++Q LS + + + + + P +
Sbjct: 484 EEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTG 543
Query: 114 QYLSLTLLHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSL 173
L++ LL+AL S L ++ Q + + + DA E + L
Sbjct: 544 GRLAIGFAVLLRAL---WKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGL 600
Query: 174 EDERDRQPRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMV 233
++ +R + V S+ P ++ H N F G+ S +V
Sbjct: 601 HEDLNRIQNKPYTETV-----DSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLV 655
Query: 234 CKHCEHQSPVRFDTFDSLSLSIP 256
C C S + FD F L + +P
Sbjct: 656 CPVCAKVS-ITFDPFLYLPVPLP 677
Score = 41.2 bits (95), Expect = 0.002
Identities = 25/81 (30%), Positives = 39/81 (48%), Gaps = 1/81 (1%)
Query: 436 FRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSAY 495
+ L AV+ H+G M GH+ R P + R+ + W D TV +V++ AY
Sbjct: 1149 YDLYAVINHYGGMIGGHYTACARLP-NDRSSQRSDVGWRLFDDSTVTTVDESQVVTRYAY 1207
Query: 496 LLFYERVLSRMQHQSQECKSE 516
+LFY R S ++ + SE
Sbjct: 1208 VLFYRRRNSPVERPPRAGHSE 1228
Score = 30.4 bits (67), Expect = 4.1
Identities = 32/109 (29%), Positives = 50/109 (45%), Gaps = 15/109 (13%)
Query: 257 AATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGK 316
AA GH TLD CL+ F E + C + + +H+ + KQL L +
Sbjct: 1052 AARAGH-FTLDQCLNLFTRPEVLAPEEAWYCPQCK----------QHREAS--KQLLLWR 1098
Query: 317 LPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLGHKPSQ 365
LP L + L+R S+ S K ++ V+F +D+ K+ +G K Q
Sbjct: 1099 LPNVLIVQLKRFSFRSFIWRDKINDLVEF-PVRNLDLSKF-CIGQKEEQ 1145
>gi|148612811 ubiquitin specific protease 43 [Homo sapiens]
Length = 1123
Score = 49.3 bits (116), Expect = 8e-06
Identities = 58/243 (23%), Positives = 86/243 (35%), Gaps = 74/243 (30%)
Query: 262 HPLTLDHCLHHFISSESVRDV---VCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLP 318
H TLD C + E + C +C ++ + +L L LP
Sbjct: 538 HSCTLDECFQFYTKEEQLAQDDAWKCPHCQVLQQG---------------MVKLSLWTLP 582
Query: 319 QCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLGHKPSQHNPKLNKNPGPTL 378
L IHL+R +R++ + + K+ L G + H + + +P L
Sbjct: 583 DILIIHLKRFCQVGE----RRNK--------LSTLVKFPLSGLNMAPHVAQRSTSPEAGL 630
Query: 379 ELQDGPGAPTPVLNQPGAPKTQIFMNGACSPSLLPTLSAPMPFPLPVVPDYSSSTYLFRL 438
P P QP LPT S P+ F L+ L
Sbjct: 631 -------GPWPSWKQPDC---------------LPT-SYPLDF-------------LYDL 654
Query: 439 MAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSAYLLF 498
AV HHG++ GH+ Y R+ S QW D TV EV + AY+LF
Sbjct: 655 YAVCNHHGNLQGGHYTAYCRN--------SLDGQWYSYDDSTVEPLREDEVNTRGAYILF 706
Query: 499 YER 501
Y++
Sbjct: 707 YQK 709
Score = 46.6 bits (109), Expect = 5e-05
Identities = 50/188 (26%), Positives = 77/188 (40%), Gaps = 16/188 (8%)
Query: 69 GLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALS 128
GL N GNTCFMN+++Q LS +L +Y + P ++ L L++AL
Sbjct: 102 GLKNHGNTCFMNAVVQCLSNTDLLAEFLA--LGRY----RAAPGRAEVTEQLAALVRALW 155
Query: 129 CQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFD 188
+E T L A + + Y Q + DA E + + ++ + R
Sbjct: 156 TREYTPQ--LSAE-FKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLEGSSR-----G 207
Query: 189 VHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTF 248
S + E T C + + P + H F + S++ C HC QS FD F
Sbjct: 208 PVSEKLPPEATKTSENCLSPSAQLPLGQSFVQSH-FQAQYRSSLTCPHCLKQSNT-FDPF 265
Query: 249 DSLSLSIP 256
+SL IP
Sbjct: 266 LCVSLPIP 273
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.133 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,300,449
Number of Sequences: 37866
Number of extensions: 1156577
Number of successful extensions: 4004
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 99
Number of HSP's successfully gapped in prelim test: 44
Number of HSP's that attempted gapping in prelim test: 3648
Number of HSP's gapped (non-prelim): 332
length of query: 517
length of database: 18,247,518
effective HSP length: 107
effective length of query: 410
effective length of database: 14,195,856
effective search space: 5820300960
effective search space used: 5820300960
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.