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Search of human proteins with 16445393
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens]
(794 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens] 1592 0.0
gi|16306530 cadherin 10, type 2 preproprotein [Homo sapiens] 987 0.0
gi|4826673 cadherin 6, type 2 preproprotein [Homo sapiens] 986 0.0
gi|90193626 cadherin 9, type 2 preproprotein [Homo sapiens] 948 0.0
gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens] 937 0.0
gi|16306487 cadherin 7, type 2 preproprotein [Homo sapiens] 926 0.0
gi|16306489 cadherin 7, type 2 preproprotein [Homo sapiens] 926 0.0
gi|16306532 cadherin 11, type 2 preproprotein [Homo sapiens] 891 0.0
gi|16306539 cadherin 8, type 2 preproprotein [Homo sapiens] 885 0.0
gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens] 882 0.0
gi|16753221 cadherin 22 precursor [Homo sapiens] 785 0.0
gi|32880203 cadherin-like 24 isoform 2 [Homo sapiens] 727 0.0
gi|32880206 cadherin-like 24 isoform 1 [Homo sapiens] 709 0.0
gi|12656655 cadherin 19, type 2 preproprotein [Homo sapiens] 691 0.0
gi|166362713 cadherin 5, type 2 preproprotein [Homo sapiens] 499 e-141
gi|14589893 cadherin 4, type 1 preproprotein [Homo sapiens] 419 e-117
gi|14589889 cadherin 2, type 1 preproprotein [Homo sapiens] 419 e-117
gi|4826669 cadherin 15 preproprotein [Homo sapiens] 374 e-103
gi|4757960 cadherin 1, type 1 preproprotein [Homo sapiens] 370 e-102
gi|14589891 cadherin 3, type 1 preproprotein [Homo sapiens] 341 2e-93
gi|4826702 desmocollin 1 isoform Dsc1b preproprotein [Homo sapiens] 245 1e-64
gi|13435361 desmocollin 1 isoform Dsc1a preproprotein [Homo sapi... 245 1e-64
gi|4502719 cadherin 13 preproprotein [Homo sapiens] 232 9e-61
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 228 2e-59
gi|13435366 desmocollin 2 isoform Dsc2b preproprotein [Homo sapi... 214 3e-55
gi|13435364 desmocollin 2 isoform Dsc2a preproprotein [Homo sapi... 214 3e-55
gi|148539848 desmocollin 3 isoform Dsc3b preproprotein [Homo sap... 211 2e-54
gi|148539846 desmocollin 3 isoform Dsc3a preproprotein [Homo sap... 211 2e-54
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 211 3e-54
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ... 206 9e-53
>gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens]
Length = 794
Score = 1592 bits (4121), Expect = 0.0
Identities = 794/794 (100%), Positives = 794/794 (100%)
Query: 1 MLTRNCLSLLLWVLFDGGLLTPLQPQPQQTLATEPRENVIHLPGQRSHFQRVKRGWVWNQ 60
MLTRNCLSLLLWVLFDGGLLTPLQPQPQQTLATEPRENVIHLPGQRSHFQRVKRGWVWNQ
Sbjct: 1 MLTRNCLSLLLWVLFDGGLLTPLQPQPQQTLATEPRENVIHLPGQRSHFQRVKRGWVWNQ 60
Query: 61 FFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDRE 120
FFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDRE
Sbjct: 61 FFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDRE 120
Query: 121 EKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVL 180
EKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVL
Sbjct: 121 EKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVL 180
Query: 181 QVKATDADDPTYGNSARVVYSILQGQPYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAK 240
QVKATDADDPTYGNSARVVYSILQGQPYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAK
Sbjct: 181 QVKATDADDPTYGNSARVVYSILQGQPYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAK 240
Query: 241 DMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQ 300
DMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQ
Sbjct: 241 DMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQ 300
Query: 301 NAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFH 360
NAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFH
Sbjct: 301 NAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFH 360
Query: 361 SAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRY 420
SAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRY
Sbjct: 361 SAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRY 420
Query: 421 FIDWKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVL 480
FIDWKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVL
Sbjct: 421 FIDWKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVL 480
Query: 481 DVNEFPPEISVPYETAVCENAKPGQIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNFTV 540
DVNEFPPEISVPYETAVCENAKPGQIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNFTV
Sbjct: 481 DVNEFPPEISVPYETAVCENAKPGQIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNFTV 540
Query: 541 RDFRNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRVCRCDSDGTILS 600
RDFRNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRVCRCDSDGTILS
Sbjct: 541 RDFRNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRVCRCDSDGTILS 600
Query: 601 CNVEAIFLPVGLSTGALIAILLCIVILLAIVVLYVALRRQKKKDTLMTSKEDIRDNVIHY 660
CNVEAIFLPVGLSTGALIAILLCIVILLAIVVLYVALRRQKKKDTLMTSKEDIRDNVIHY
Sbjct: 601 CNVEAIFLPVGLSTGALIAILLCIVILLAIVVLYVALRRQKKKDTLMTSKEDIRDNVIHY 660
Query: 661 DDEGGGEEDTQAFDIGALRNPKVIEENKIRRDIKPDSLCLPRQRPPMEDNTDIRDFIHQR 720
DDEGGGEEDTQAFDIGALRNPKVIEENKIRRDIKPDSLCLPRQRPPMEDNTDIRDFIHQR
Sbjct: 661 DDEGGGEEDTQAFDIGALRNPKVIEENKIRRDIKPDSLCLPRQRPPMEDNTDIRDFIHQR 720
Query: 721 LQENDVDPTAPPYDSLATYAYEGSGSVAESLSSIDSLTTEADQDYDYLTDWGPRFKVLAD 780
LQENDVDPTAPPYDSLATYAYEGSGSVAESLSSIDSLTTEADQDYDYLTDWGPRFKVLAD
Sbjct: 721 LQENDVDPTAPPYDSLATYAYEGSGSVAESLSSIDSLTTEADQDYDYLTDWGPRFKVLAD 780
Query: 781 MFGEEESYNPDKVT 794
MFGEEESYNPDKVT
Sbjct: 781 MFGEEESYNPDKVT 794
>gi|16306530 cadherin 10, type 2 preproprotein [Homo sapiens]
Length = 788
Score = 987 bits (2552), Expect = 0.0
Identities = 480/763 (62%), Positives = 608/763 (79%), Gaps = 8/763 (1%)
Query: 25 PQPQQTLATEPRENVIHLPGQRSHFQRVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDK 84
P PQQ + + V G+ H R KRGW+WNQFF+LEEY GS+ QYVGKLHSD DK
Sbjct: 30 PVPQQRILSS---RVPRSDGKILH--RQKRGWMWNQFFLLEEYTGSDYQYVGKLHSDQDK 84
Query: 85 GEGTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPES 144
G+G++KY LSGDGAGT+F IDE TGDIHA R +DREEK FYTLRAQA++ T +P+EPES
Sbjct: 85 GDGSLKYILSGDGAGTLFIIDEKTGDIHATRRIDREEKAFYTLRAQAINRRTLRPVEPES 144
Query: 145 EFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQ 204
EF+IK+ DINDNEP F + Y A+VPEMS VG V+QV ATDADDP+YGNSARV+YSILQ
Sbjct: 145 EFVIKIHDINDNEPTFPEEIYTASVPEMSVVGTSVVQVTATDADDPSYGNSARVIYSILQ 204
Query: 205 GQPYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVND 264
GQPYFS++P+TG+IRTALPNM+RE +EQYQV+IQAKDMGGQ+GGL+GTT VNITLTDVND
Sbjct: 205 GQPYFSVEPETGIIRTALPNMNRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVND 264
Query: 265 NPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGGNLFDIVTDED 324
NPPRFP++ HL+V ESSP+G+AIG ++A D D G+NAE+EY I+ GDG ++FDIVT++D
Sbjct: 265 NPPRFPQNTIHLRVLESSPVGTAIGSVKATDADTGKNAEVEYRIIDGDGTDMFDIVTEKD 324
Query: 325 TQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTATVKISVLDVDEPPVF 384
TQEG+I +KKPLD+E+++ YT KVEA N H+D RF+ GPFKDT VKIS+ DVDEPPVF
Sbjct: 325 TQEGIITVKKPLDYESRRLYTLKVEAENTHVDPRFYYLGPFKDTTIVKISIEDVDEPPVF 384
Query: 385 SKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRYFIDWKSDGDSYFTIDGNEGTIATN 444
S+ Y EV+ED VGTIIG V A+D D SS +R+ +D +D D F I G++ T+
Sbjct: 385 SRSSYLFEVHEDIEVGTIIGTVMARDPDSISSPIRFSLDRHTDLDRIFNIHSGNGSLYTS 444
Query: 445 ELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPEISVPYETAVCENAKPG 504
+ LDRE + +N ++IA++++NP T++V + + +LDVN+ P+ +V Y+T VCENA+PG
Sbjct: 445 KPLDRELSQWHNLTVIAAEINNPKETTRVAVFVRILDVNDNAPQFAVFYDTFVCENARPG 504
Query: 505 QIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNFTVRDFRNNTAGIETRRNGYSRRQQEL 564
Q+IQ +SA D+D GQ+F F L AA+ PNFTV+D +NTA I TR+NG++R +
Sbjct: 505 QLIQTISAVDKDDPLGGQKFFFSL---AAVNPNFTVQDNEDNTARILTRKNGFNRHEIST 561
Query: 565 YFLPVVIEDSSYPVQSSTNTMTIRVCRCDSDGTILSCNVEAIFLPVGLSTGALIAILLCI 624
Y LPVVI D+ YP+QSST T+TIRVC CDS G + SC+ EA+ LP GLSTGALIAILLCI
Sbjct: 562 YLLPVVISDNDYPIQSSTGTLTIRVCACDSQGNMQSCSAEALLLPAGLSTGALIAILLCI 621
Query: 625 VILLAIVVLYVALRRQKKKDTLMTSKEDIRDNVIHYDDEGGGEEDTQAFDIGALRNPKVI 684
+ILL IVVL+ AL+RQ+KK+ L+ SKEDIRDN++ Y+DEGGGEEDTQAFDIG LRNP I
Sbjct: 622 IILLVIVVLFAALKRQRKKEPLILSKEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPAAI 681
Query: 685 EENKIRRDIKPDSLCLPRQRPPMEDNTDIRDFIHQRLQENDVDPTAPPYDSLATYAYEGS 744
EE K+RRDI P++L +PR+ P DNTD+RDFI++RL+E+D+DPTAPPYDSLATYAYEG+
Sbjct: 682 EEKKLRRDIIPETLFIPRRTPTAPDNTDVRDFINERLKEHDLDPTAPPYDSLATYAYEGN 741
Query: 745 GSVAESLSSIDSLTTEADQDYDYLTDWGPRFKVLADMFGEEES 787
S+AESLSS++S TTE DQ+YDYL +WGPRF LA+M+G ES
Sbjct: 742 DSIAESLSSLESGTTEGDQNYDYLREWGPRFNKLAEMYGGGES 784
>gi|4826673 cadherin 6, type 2 preproprotein [Homo sapiens]
Length = 790
Score = 986 bits (2548), Expect = 0.0
Identities = 487/788 (61%), Positives = 611/788 (77%), Gaps = 3/788 (0%)
Query: 1 MLTRNCLSLLLWVLFDGGLLTPLQPQPQQTLATEPRENVIHLPGQ-RSHFQRVKRGWVWN 59
M T LL WV L+ P ++T ++ + L G ++ R KR W+WN
Sbjct: 1 MRTYRYFLLLFWVGQPYPTLST--PLSKRTSGFPAKKRALELSGNSKNELNRSKRSWMWN 58
Query: 60 QFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDR 119
QFF+LEEY GS+ QYVGKLHSD D+G+G++KY LSGDGAG +F I+E TGDI A + LDR
Sbjct: 59 QFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDR 118
Query: 120 EEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYV 179
EEKP Y LRAQA++ T +P+EPESEFIIK+ DINDNEP F Y ATVPEMS VG +V
Sbjct: 119 EEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFV 178
Query: 180 LQVKATDADDPTYGNSARVVYSILQGQPYFSIDPKTGVIRTALPNMDREVKEQYQVLIQA 239
+QV ATDADDPTYGNSA+VVYSILQGQPYFS++ +TG+I+TAL NMDRE +EQYQV+IQA
Sbjct: 179 VQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQA 238
Query: 240 KDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFG 299
KDMGGQ+GGL+GTT VNITLTDVNDNPPRFP+S + K PESSP G+ IGRI+A D D G
Sbjct: 239 KDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVG 298
Query: 300 QNAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRF 359
+NAEIEY+I G+G ++FD++TD++TQEG+I +KK LDFE KK YT KVEASN +++ RF
Sbjct: 299 ENAEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRF 358
Query: 360 HSAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVR 419
GPFKD+ATV+I V DVDEPPVFSK Y +++ ED + T IG+VTAQD D + V+
Sbjct: 359 LYLGPFKDSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVK 418
Query: 420 YFIDWKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINV 479
Y +D +D D F ID G+I T++LLDRE+ +N ++IA++++NP +S+V + I V
Sbjct: 419 YSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKV 478
Query: 480 LDVNEFPPEISVPYETAVCENAKPGQIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNFT 539
LDVN+ PE + YET VCE AK Q+IQ + A D+D +G QFSF L+PEAA NFT
Sbjct: 479 LDVNDNAPEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFT 538
Query: 540 VRDFRNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRVCRCDSDGTIL 599
++D ++NTAGI TR+NGY+R + Y LPVVI D+ YPVQSST T+T+RVC CD G +
Sbjct: 539 IQDNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQ 598
Query: 600 SCNVEAIFLPVGLSTGALIAILLCIVILLAIVVLYVALRRQKKKDTLMTSKEDIRDNVIH 659
SC+ EA+ P GLSTGAL+AILLCIVILL VVL+ ALRRQ+KK+ L+ SKEDIRDN++
Sbjct: 599 SCHAEALIHPTGLSTGALVAILLCIVILLVTVVLFAALRRQRKKEPLIISKEDIRDNIVS 658
Query: 660 YDDEGGGEEDTQAFDIGALRNPKVIEENKIRRDIKPDSLCLPRQRPPMEDNTDIRDFIHQ 719
Y+DEGGGEEDTQAFDIG LRNP+ IE+NK+RRDI P++L LPR+ P DNTD+RDFI+Q
Sbjct: 659 YNDEGGGEEDTQAFDIGTLRNPEAIEDNKLRRDIVPEALFLPRRTPTARDNTDVRDFINQ 718
Query: 720 RLQENDVDPTAPPYDSLATYAYEGSGSVAESLSSIDSLTTEADQDYDYLTDWGPRFKVLA 779
RL+END DPTAPPYDSLATYAYEG+GSVA+SLSS++S+TT+ADQDYDYL+DWGPRFK LA
Sbjct: 719 RLKENDTDPTAPPYDSLATYAYEGTGSVADSLSSLESVTTDADQDYDYLSDWGPRFKKLA 778
Query: 780 DMFGEEES 787
DM+G +S
Sbjct: 779 DMYGGVDS 786
>gi|90193626 cadherin 9, type 2 preproprotein [Homo sapiens]
Length = 789
Score = 948 bits (2451), Expect = 0.0
Identities = 454/788 (57%), Positives = 603/788 (76%), Gaps = 3/788 (0%)
Query: 1 MLTRNCLSLLLWV-LFDGGLLTPLQPQPQQTLATEPRENVIHLPGQRSHFQRVKRGWVWN 59
M T + + L +W +F LQ +P L+++ + G+ +R KRGW+WN
Sbjct: 1 MRTYHYIPLFIWTYMFHTVDTILLQEKPNSYLSSKKIAGLTKDDGKM--LRRTKRGWMWN 58
Query: 60 QFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDR 119
QFF+LEEY G++ QYVGKLH+D DKG+G +KY L+GDGAG++F IDE TGDIHA + LDR
Sbjct: 59 QFFLLEEYTGTDTQYVGKLHTDQDKGDGNLKYILTGDGAGSLFVIDENTGDIHAAKKLDR 118
Query: 120 EEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYV 179
EEK Y LRA+A+D +T + +EPESEFIIK+ DINDNEPKF Y A+VPEMS VG V
Sbjct: 119 EEKSLYILRAKAIDRKTGRQVEPESEFIIKIHDINDNEPKFTKDLYTASVPEMSGVGTSV 178
Query: 180 LQVKATDADDPTYGNSARVVYSILQGQPYFSIDPKTGVIRTALPNMDREVKEQYQVLIQA 239
+QV ATDADD YGNSA+VVYSILQGQPYFS+DP++G+I+TALP+M RE +EQYQV+IQA
Sbjct: 179 IQVTATDADDANYGNSAKVVYSILQGQPYFSVDPESGIIKTALPDMSRENREQYQVVIQA 238
Query: 240 KDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFG 299
KDMGGQ+GGL+GTT VNITLTDVN+NPPRFP+S + PES P+G+ +GRI+A DPD G
Sbjct: 239 KDMGGQMGGLSGTTTVNITLTDVNNNPPRFPQSTYQFNSPESVPLGTHLGRIKANDPDVG 298
Query: 300 QNAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRF 359
+NAE+EY+I GDG ++FD++TD+DTQEG+I +K+ LDFE + YT +V+ASN H D RF
Sbjct: 299 ENAEMEYSIAEGDGADMFDVITDKDTQEGIITVKQNLDFENQMLYTLRVDASNTHPDPRF 358
Query: 360 HSAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVR 419
GPFKDTA VKISV D+DEPPVF+K Y +EV ED G+IIG VTA D D ++ ++
Sbjct: 359 LHLGPFKDTAVVKISVEDIDEPPVFTKVSYLIEVDEDVKEGSIIGQVTAYDPDARNNLIK 418
Query: 420 YFIDWKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINV 479
Y +D +D D F I G+I T + LDRES+ +N ++ A++++NP +S + + I +
Sbjct: 419 YSVDRHTDMDRIFGIHSENGSIFTLKALDRESSPWHNITVTATEINNPKQSSHIPVFIRI 478
Query: 480 LDVNEFPPEISVPYETAVCENAKPGQIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNFT 539
LD+N+ PE ++ YET VCENAKPGQ+IQ VS D+D P G +F F PE + PNFT
Sbjct: 479 LDINDHAPEFAMYYETFVCENAKPGQLIQTVSVMDKDDPPRGHKFFFEPVPEFTLNPNFT 538
Query: 540 VRDFRNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRVCRCDSDGTIL 599
+ D ++NTAGI TR++GYSR + Y LP++I D+ YP+QSST T+TIRVC CD+ G +
Sbjct: 539 IVDNKDNTAGIMTRKDGYSRNKMSTYLLPILIFDNDYPIQSSTGTLTIRVCACDNQGNMQ 598
Query: 600 SCNVEAIFLPVGLSTGALIAILLCIVILLAIVVLYVALRRQKKKDTLMTSKEDIRDNVIH 659
SC EA+ L GLSTGAL+AILLC++ILL +VVL+ AL+RQ+KK+ L+ SK+D+RDN++
Sbjct: 599 SCTAEALILSAGLSTGALVAILLCVLILLILVVLFAALKRQRKKEPLIISKDDVRDNIVT 658
Query: 660 YDDEGGGEEDTQAFDIGALRNPKVIEENKIRRDIKPDSLCLPRQRPPMEDNTDIRDFIHQ 719
Y+DEGGGEEDTQAFDIG LRNP+ E++K+RRD+ P+++ R+ P+ +N D++DFIH+
Sbjct: 659 YNDEGGGEEDTQAFDIGTLRNPEAREDSKLRRDVMPETIFQIRRTVPLWENIDVQDFIHR 718
Query: 720 RLQENDVDPTAPPYDSLATYAYEGSGSVAESLSSIDSLTTEADQDYDYLTDWGPRFKVLA 779
RL+END DP+APPYDSLATYAYEG+ S+A+SLSS++SLT + +QDYDYL+DWGPRFK LA
Sbjct: 719 RLKENDADPSAPPYDSLATYAYEGNDSIADSLSSLESLTADCNQDYDYLSDWGPRFKKLA 778
Query: 780 DMFGEEES 787
DM+G ++S
Sbjct: 779 DMYGGDDS 786
>gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens]
Length = 790
Score = 937 bits (2423), Expect = 0.0
Identities = 455/753 (60%), Positives = 573/753 (76%), Gaps = 2/753 (0%)
Query: 36 RENVIHLPGQRSHFQRVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSG 95
R H+ G+ R KRGWVWNQFFVLEE++G +PQYVGKLHS+ DKG+G+VKY L+G
Sbjct: 35 RNQTKHIEGETEVHHRPKRGWVWNQFFVLEEHMGPDPQYVGKLHSNSDKGDGSVKYILTG 94
Query: 96 DGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDIND 155
+GAGT+F ID+TTGDIH+ +SLDRE+K Y L AQA+D T KPLEPESEFIIKVQDIND
Sbjct: 95 EGAGTIFIIDDTTGDIHSTKSLDREQKTHYVLHAQAIDRRTNKPLEPESEFIIKVQDIND 154
Query: 156 NEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQPYFSIDPKT 215
N PKF DGPY+ TVPEMS +G VLQV ATDADDPTYGNSARVVYSILQGQPYFS+DPKT
Sbjct: 155 NAPKFTDGPYIVTVPEMSDMGTSVLQVTATDADDPTYGNSARVVYSILQGQPYFSVDPKT 214
Query: 216 GVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFH 275
GVIRTAL NMDRE +E Y V+IQAKDM GQ+GGL+G+T VNITLTDVNDNPPRFP+ +
Sbjct: 215 GVIRTALHNMDREAREHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQ 274
Query: 276 LKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKP 335
L VPES+ +GSA+G+I+A D D G NA++ Y+I+ GDG +F I TD++T+EG++ LKKP
Sbjct: 275 LYVPESAQVGSAVGKIKANDADTGSNADMTYSIINGDGMGIFSISTDKETREGILSLKKP 334
Query: 336 LDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYE 395
L++E KK+YT +E +N HLD RF GPFKD +KI V DVDEPP+FS P Y MEVYE
Sbjct: 335 LNYEKKKSYTLNIEGANTHLDFRFSHLGPFKDATMLKIIVGDVDEPPLFSMPSYLMEVYE 394
Query: 396 DTPVGTIIGAVTAQDLDVGSSAVRYFIDWKSDGDSYFTIDGNEGTIATNELLDRESTAQY 455
+ +GT++G V AQD D +S VRYFI++ + D +F ID N GTI T ++LDRE T Y
Sbjct: 395 NAKIGTVVGTVLAQDPDSTNSLVRYFINYNVEDDRFFNIDANTGTIRTTKVLDREETPWY 454
Query: 456 NFSIIASKVSNPLLTSKVNILINVLDVNEFPPEISVPYETAVCENAKPGQIIQIVSAADR 515
N ++ AS++ NP L S V + I VLDVN+ PPE++ Y+ VCEN+KPGQ+I +SA D+
Sbjct: 455 NITVTASEIDNPDLLSHVTVGIRVLDVNDNPPELAREYDIIVCENSKPGQVIHTISATDK 514
Query: 516 DLSPAGQQFSFRLSPEAAIKPNFTVRDFRNNTAGIETRRNGYSRRQQELYFLPVVIEDSS 575
D G +F+F L + PNFT++D +NTA I TRR +SR Q++Y+LP++I D
Sbjct: 515 DDFANGPRFNFFLDERLPVNPNFTLKDNEDNTASILTRRRRFSRTVQDVYYLPIMISDGG 574
Query: 576 YPVQSSTNTMTIRVCRCDSDGTILSCNVEAIFLPVGLSTGALIAILLCIVILLAIVVLYV 635
P SS++T+TIRVC C+ DG + +C+ EA GLSTGALIAILLC++ILLAIVVL++
Sbjct: 575 IPSLSSSSTLTIRVCACERDGRVRTCHAEAFLSSAGLSTGALIAILLCVLILLAIVVLFI 634
Query: 636 ALRRQKKKDTLMTSKEDIRDNVIHYDDEGGGEEDTQAFDIGALRNPKVIEENKIRRDIKP 695
LRR KK+ L+ S+ED+R+NV+ YDDEGGGEEDT+AFDI ALRNP EE K RRDI+P
Sbjct: 635 TLRR-SKKEPLIISEEDVRENVVTYDDEGGGEEDTEAFDITALRNPSAAEELKYRRDIRP 693
Query: 696 DSLCLPR-QRPPMEDNTDIRDFIHQRLQENDVDPTAPPYDSLATYAYEGSGSVAESLSSI 754
+ PR Q ++ D+++FI QRL E D+DP+ PPYDSL TYAYEG S A S+SS+
Sbjct: 694 EVKLTPRHQTSSTLESIDVQEFIKQRLAEADLDPSVPPYDSLQTYAYEGQRSEAGSISSL 753
Query: 755 DSLTTEADQDYDYLTDWGPRFKVLADMFGEEES 787
DS TT++DQDY YL DWGP FK LA+++GE ES
Sbjct: 754 DSATTQSDQDYHYLGDWGPEFKKLAELYGEIES 786
>gi|16306487 cadherin 7, type 2 preproprotein [Homo sapiens]
Length = 785
Score = 926 bits (2394), Expect = 0.0
Identities = 452/742 (60%), Positives = 563/742 (75%), Gaps = 1/742 (0%)
Query: 43 PGQRSHFQRVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGTVF 102
P +S R KR WVWNQFFVLEEY+GS+P YVGKLHSD+DKG+G++KY LSG+GA ++F
Sbjct: 36 PYFQSGRSRTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIF 95
Query: 103 TIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLD 162
IDE TGDIHA + LDREE+ +YTLRAQA+D T KP+EPESEF+IK+QDINDNEPKFLD
Sbjct: 96 IIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLD 155
Query: 163 GPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQPYFSIDPKTGVIRTAL 222
GPY A VPEMSPVG V+QV ATDADDPTYGNSARVVYSILQGQPYFS++PKTGVI+TAL
Sbjct: 156 GPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTAL 215
Query: 223 PNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESS 282
PNMDRE K+QY ++IQAKDM GQ GGL+GTT V +TLTDVNDNPPRFP+ + VPES
Sbjct: 216 PNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESL 275
Query: 283 PIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKK 342
P+ S + RI+A D D G NAE+EY IV GDG +F I D++TQEG+I ++K LDFE K
Sbjct: 276 PVASVVARIKAADADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAKT 335
Query: 343 AYTFKVEASNLHLDHRFHSAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTPVGTI 402
+YT ++EA+N D RF S GPF DT TVKI V DVDEPPVFS PLY MEV E T VG I
Sbjct: 336 SYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNI 395
Query: 403 IGAVTAQDLDVGSSAVRYFIDWKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIAS 462
IG V A D D +S VRY ID +D + YF ID N G I T + LDRE+ A +N +++A
Sbjct: 396 IGTVAAHDPDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAM 455
Query: 463 KVSNPLLTSKVNILINVLDVNEFPPEISVPYETAVCENAKPGQIIQIVSAADRDLSPAGQ 522
+ NP + + I +LD+N+ PE ++ YET VCENA+PGQ+IQ +SA D+D G
Sbjct: 456 ESQNPSQVGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDKDEPSNGH 515
Query: 523 QFSFRLSPEAAIKPNFTVRDFRNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSST 582
QF F L+ +A NF+++D ++NTA I TRRNG+ R++Q +Y+LP+ I DS P SST
Sbjct: 516 QFYFSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSST 575
Query: 583 NTMTIRVCRCDSDGTILSCNVEAIFLPVGLSTGALIAILLCIVILLAIVVLYVALRRQKK 642
NT+TIRVC CD+DG +CN EA LP GLSTGALIAIL C++ LL +++L V +RR+KK
Sbjct: 576 NTLTIRVCDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLILLIVTMRRRKK 635
Query: 643 KDTLMTSKEDIRDNVIHYDDEGGGEEDTQAFDIGALRNPKVIEENKIRRDIKPDSLCLPR 702
+ + + DIR+N++ YDDEGGGEEDT+AFD+ ALRN VI + K RRD+ P+ L R
Sbjct: 636 EPLIFDEERDIRENIVRYDDEGGGEEDTEAFDMAALRNLNVIRDTKTRRDVTPEIQFLSR 695
Query: 703 QR-PPMEDNTDIRDFIHQRLQENDVDPTAPPYDSLATYAYEGSGSVAESLSSIDSLTTEA 761
+ DN R+FI +RL+E DVDP APPYDSL TYA+EG+GSVAESLSS+DS+++ +
Sbjct: 696 PAFKSIPDNVIFREFIWERLKEADVDPGAPPYDSLQTYAFEGNGSVAESLSSLDSISSNS 755
Query: 762 DQDYDYLTDWGPRFKVLADMFG 783
DQ+YDYL+DWGPRFK LADM+G
Sbjct: 756 DQNYDYLSDWGPRFKRLADMYG 777
>gi|16306489 cadherin 7, type 2 preproprotein [Homo sapiens]
Length = 785
Score = 926 bits (2394), Expect = 0.0
Identities = 452/742 (60%), Positives = 563/742 (75%), Gaps = 1/742 (0%)
Query: 43 PGQRSHFQRVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGTVF 102
P +S R KR WVWNQFFVLEEY+GS+P YVGKLHSD+DKG+G++KY LSG+GA ++F
Sbjct: 36 PYFQSGRSRTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIF 95
Query: 103 TIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLD 162
IDE TGDIHA + LDREE+ +YTLRAQA+D T KP+EPESEF+IK+QDINDNEPKFLD
Sbjct: 96 IIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLD 155
Query: 163 GPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQPYFSIDPKTGVIRTAL 222
GPY A VPEMSPVG V+QV ATDADDPTYGNSARVVYSILQGQPYFS++PKTGVI+TAL
Sbjct: 156 GPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTAL 215
Query: 223 PNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESS 282
PNMDRE K+QY ++IQAKDM GQ GGL+GTT V +TLTDVNDNPPRFP+ + VPES
Sbjct: 216 PNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESL 275
Query: 283 PIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKK 342
P+ S + RI+A D D G NAE+EY IV GDG +F I D++TQEG+I ++K LDFE K
Sbjct: 276 PVASVVARIKAADADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAKT 335
Query: 343 AYTFKVEASNLHLDHRFHSAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTPVGTI 402
+YT ++EA+N D RF S GPF DT TVKI V DVDEPPVFS PLY MEV E T VG I
Sbjct: 336 SYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNI 395
Query: 403 IGAVTAQDLDVGSSAVRYFIDWKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIAS 462
IG V A D D +S VRY ID +D + YF ID N G I T + LDRE+ A +N +++A
Sbjct: 396 IGTVAAHDPDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAM 455
Query: 463 KVSNPLLTSKVNILINVLDVNEFPPEISVPYETAVCENAKPGQIIQIVSAADRDLSPAGQ 522
+ NP + + I +LD+N+ PE ++ YET VCENA+PGQ+IQ +SA D+D G
Sbjct: 456 ESQNPSQVGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDKDEPSNGH 515
Query: 523 QFSFRLSPEAAIKPNFTVRDFRNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSST 582
QF F L+ +A NF+++D ++NTA I TRRNG+ R++Q +Y+LP+ I DS P SST
Sbjct: 516 QFYFSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSST 575
Query: 583 NTMTIRVCRCDSDGTILSCNVEAIFLPVGLSTGALIAILLCIVILLAIVVLYVALRRQKK 642
NT+TIRVC CD+DG +CN EA LP GLSTGALIAIL C++ LL +++L V +RR+KK
Sbjct: 576 NTLTIRVCDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLILLIVTMRRRKK 635
Query: 643 KDTLMTSKEDIRDNVIHYDDEGGGEEDTQAFDIGALRNPKVIEENKIRRDIKPDSLCLPR 702
+ + + DIR+N++ YDDEGGGEEDT+AFD+ ALRN VI + K RRD+ P+ L R
Sbjct: 636 EPLIFDEERDIRENIVRYDDEGGGEEDTEAFDMAALRNLNVIRDTKTRRDVTPEIQFLSR 695
Query: 703 QR-PPMEDNTDIRDFIHQRLQENDVDPTAPPYDSLATYAYEGSGSVAESLSSIDSLTTEA 761
+ DN R+FI +RL+E DVDP APPYDSL TYA+EG+GSVAESLSS+DS+++ +
Sbjct: 696 PAFKSIPDNVIFREFIWERLKEADVDPGAPPYDSLQTYAFEGNGSVAESLSSLDSISSNS 755
Query: 762 DQDYDYLTDWGPRFKVLADMFG 783
DQ+YDYL+DWGPRFK LADM+G
Sbjct: 756 DQNYDYLSDWGPRFKRLADMYG 777
>gi|16306532 cadherin 11, type 2 preproprotein [Homo sapiens]
Length = 796
Score = 891 bits (2303), Expect = 0.0
Identities = 439/747 (58%), Positives = 561/747 (75%), Gaps = 5/747 (0%)
Query: 50 QRVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGTVFTIDETTG 109
QR KRGWVWNQFFV+EEY G +P VG+LHSD+D G+G +KY LSG+GAGT+F ID+ +G
Sbjct: 49 QRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKYILSGEGAGTIFVIDDKSG 108
Query: 110 DIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPYVATV 169
+IHA ++LDREE+ YTL AQAVD +T +PLEP SEFI+KVQDINDN P+FL Y A V
Sbjct: 109 NIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANV 168
Query: 170 PEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQPYFSIDPKTGVIRTALPNMDREV 229
PE S VG V+QV A+DADDPTYGNSA++VYSIL+GQPYFS++ +TG+IRTALPNMDRE
Sbjct: 169 PERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREA 228
Query: 230 KEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIG 289
KE+Y V+IQAKDMGG +GGL+GTT V ITLTDVNDNPP+FP+S++ + V E++ G +G
Sbjct: 229 KEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSEAAVPGEEVG 288
Query: 290 RIRAVDPDFGQNAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVE 349
R++A DPD G+N + YNIV GDG F+I TD +TQEGVIKLKKP+DFETK+AY+ KVE
Sbjct: 289 RVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVE 348
Query: 350 ASNLHLDHRFHSAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQ 409
A+N+H+D +F S GPFKDT TVKISV D DEPP+F P Y EV E+ GT++G V A+
Sbjct: 349 AANVHIDPKFISNGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAK 408
Query: 410 DLDVGSSAVRYFIDWKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPLL 469
D D +S +RY ID +D D +FTI+ +G I T + LDRE TA N ++ A+++ N
Sbjct: 409 DPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEIHNRHQ 468
Query: 470 TSKVNILINVLDVNEFPPEISVPYETAVCEN--AKP--GQIIQIVSAADRDLSPAGQQFS 525
+KV + I VLDVN+ P+ + PYE +CE+ KP Q I +SA D+D + G +F
Sbjct: 469 EAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFI 528
Query: 526 FRLSPEAAIKPNFTVRDFRNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTM 585
F L PE PNFTVRD R+NTAG+ RR G+SR++Q+LY LP+VI D P SSTNT+
Sbjct: 529 FSLPPEIIHNPNFTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPMSSTNTL 588
Query: 586 TIRVCRCDSDGTILSCNVEAIFLPVGLSTGALIAILLCIVILLAIVVLYVALRRQKKKDT 645
TI+VC CD +G +LSCN EA L GLSTGALIAIL CIVILL IVVL+V LRRQKK+
Sbjct: 589 TIKVCGCDVNGALLSCNAEAYILNAGLSTGALIAILACIVILLVIVVLFVTLRRQKKEPL 648
Query: 646 LMTSKEDIRDNVIHYDDEGGGEEDTQAFDIGALRNPKVIEENKIRRDIKPDSLCLPRQ-R 704
++ +ED+R+N+I YDDEGGGEEDT+AFDI L+NP I R+DIKP+ +PR
Sbjct: 649 IVFEEEDVRENIITYDDEGGGEEDTEAFDIATLQNPDGINGFIPRKDIKPEYQYMPRPGL 708
Query: 705 PPMEDNTDIRDFIHQRLQENDVDPTAPPYDSLATYAYEGSGSVAESLSSIDSLTTEADQD 764
P ++ D+ DFI+ R+QE D DPTAPPYDS+ Y YEG GSVA SLSS++S TT++D D
Sbjct: 709 RPAPNSVDVDDFINTRIQEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESATTDSDLD 768
Query: 765 YDYLTDWGPRFKVLADMFGEEESYNPD 791
YDYL +WGPRFK LAD++G +++++ D
Sbjct: 769 YDYLQNWGPRFKKLADLYGSKDTFDDD 795
>gi|16306539 cadherin 8, type 2 preproprotein [Homo sapiens]
Length = 799
Score = 885 bits (2287), Expect = 0.0
Identities = 437/780 (56%), Positives = 567/780 (72%), Gaps = 2/780 (0%)
Query: 9 LLLWVLFDGGLLTPLQPQPQQTLATEPRENVIHLPGQRSHFQRVKRGWVWNQFFVLEEYV 68
++LW+ + Q Q ++ P E + L ++ R KRGWVWNQ FVLEE+
Sbjct: 17 IILWITLPPCIYMAPMNQSQVLMSGSPLE-LNSLGEEQRILNRSKRGWVWNQMFVLEEFS 75
Query: 69 GSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLR 128
G EP VG+LH+DLD G +KY LSGDGAGT+F I++ TGDIHAI+ LDREEK YTL
Sbjct: 76 GPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTLT 135
Query: 129 AQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDAD 188
AQAVD ET KPLEP SEFIIKVQDINDN P+FL+GPY ATVPEMS +G V V ATDAD
Sbjct: 136 AQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDAD 195
Query: 189 DPTYGNSARVVYSILQGQPYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGG 248
DP YGNSA++VYSIL+GQPYFSI+P+T +I+TALPNMDRE KE+Y V+IQAKDMGG GG
Sbjct: 196 DPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGG 255
Query: 249 LAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNI 308
L+GTT + +TLTDVNDNPP+F +S++H VPE +G+AIGR++A D D G+NA+ Y+I
Sbjct: 256 LSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDI 315
Query: 309 VPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDT 368
+ GDG LF+I +D Q+G+I+L+KPLDFETKK+YT KVEA+N+H+D RF GPFKDT
Sbjct: 316 IDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDT 375
Query: 369 ATVKISVLDVDEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRYFIDWKSDG 428
ATVKI V D DEPPVFS P Y +EV+E+ + ++IG VTA+D D+ SS +R+ ID +D
Sbjct: 376 ATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSPIRFSIDRHTDL 435
Query: 429 DSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPE 488
+ F I+ ++G I LDRE + +N +IIA+++ N S+V + I VLDVN+ PE
Sbjct: 436 ERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPE 495
Query: 489 ISVPYETAVCENAKPGQIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNFTVRDFRNNTA 548
+ YE +CEN KPGQ+IQ VSA D+D G F + L PE PNFT++ +N+
Sbjct: 496 FASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNEDNSL 555
Query: 549 GIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRVCRCDSDGTILSCNVEAIFL 608
I + NG++R++QE+Y LP++I DS P SST+T+TIRVC C +DG + SCNVEA L
Sbjct: 556 SILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVEAYVL 615
Query: 609 PVGLSTGALIAILLCIVILLAIVVLYVALRRQKKKDTLMTSKEDIRDNVIHYDDEGGGEE 668
P+GLS GALIAIL CI++LL IVVL+V LRR K + ++ ED+R+N+I YDDEGGGEE
Sbjct: 616 PIGLSMGALIAILACIILLLVIVVLFVTLRRHKNEPLIIKDDEDVRENIIRYDDEGGGEE 675
Query: 669 DTQAFDIGALRNPKVIEENKIRRDIKPDSLCLPRQ-RPPMEDNTDIRDFIHQRLQENDVD 727
DT+AFDI L+NP I R+DIKPD +PRQ P+ + D+ +FI+ RL E D D
Sbjct: 676 DTEAFDIATLQNPDGINGFLPRKDIKPDLQFMPRQGLAPVPNGVDVDEFINVRLHEADND 735
Query: 728 PTAPPYDSLATYAYEGSGSVAESLSSIDSLTTEADQDYDYLTDWGPRFKVLADMFGEEES 787
PTAPPYDS+ Y YEG GSVA SLSS++S T+++DQ++DYL+DWGPRFK L +++ ES
Sbjct: 736 PTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFDYLSDWGPRFKRLGELYSVGES 795
>gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens]
Length = 801
Score = 882 bits (2278), Expect = 0.0
Identities = 450/791 (56%), Positives = 576/791 (72%), Gaps = 16/791 (2%)
Query: 7 LSLLLWVLFDGGLLTPL---QPQPQQTLATEPRENVIHLPGQRSHFQRVKRGWVWNQFFV 63
+SL W L D L T + P PQ L + +SH QR KR WVWNQFFV
Sbjct: 18 MSLYFWGLMD--LTTTVLSDTPTPQGELEALLSDK------PQSH-QRTKRSWVWNQFFV 68
Query: 64 LEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKP 123
LEEY G++P YVGKLHSD+D+G+G++KY LSG+GAG VFTID+TTGDIHAI+ LDREE+
Sbjct: 69 LEEYTGTDPLYVGKLHSDMDRGDGSIKYILSGEGAGIVFTIDDTTGDIHAIQRLDREERA 128
Query: 124 FYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVK 183
YTLRAQA+D T +P+EPESEFIIK+QDINDNEPKFLDGPYVATVPEMSPVG V+QV
Sbjct: 129 QYTLRAQALDRRTGRPMEPESEFIIKIQDINDNEPKFLDGPYVATVPEMSPVGTSVIQVT 188
Query: 184 ATDADDPTYGNSARVVYSILQGQPYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMG 243
ATDADDPTYGNSARVVYSILQGQPYFS+D KTGVIRTAL NMDRE KE Y+V+IQAKDMG
Sbjct: 189 ATDADDPTYGNSARVVYSILQGQPYFSVDSKTGVIRTALMNMDREAKEYYEVIIQAKDMG 248
Query: 244 GQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNAE 303
GQLGGLAGTT VNITL+DVNDNPPRFP+ + + V ES+PI S +GR+ A D D G NAE
Sbjct: 249 GQLGGLAGTTTVNITLSDVNDNPPRFPQKHYQMSVLESAPISSTVGRVFAKDLDEGINAE 308
Query: 304 IEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAG 363
++Y IV GDG + FDI TD + Q G+I +KKPL FE+KK+YT KVE +N HL+ RF + G
Sbjct: 309 MKYTIVDGDGADAFDISTDPNFQVGIITVKKPLSFESKKSYTLKVEGANPHLEMRFLNLG 368
Query: 364 PFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRYFID 423
PF+DT TV ISV DVDEPPVF Y +EV ED +GT I ++A+D DV ++++RY ID
Sbjct: 369 PFQDTTTVHISVEDVDEPPVFEPGFYFVEVPEDVAIGTTIQIISAKDPDVTNNSIRYSID 428
Query: 424 WKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVLDVN 483
SD +F +D G + T LDRE + +N +++A +++NP V + I VLDVN
Sbjct: 429 RSSDPGRFFYVDITTGALMTARPLDREEFSWHNITVLAMEMNNPSQVGSVPVTIKVLDVN 488
Query: 484 EFPPEISVPYETAVCENAKPGQIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNFTVRDF 543
+ PE YE VCENAK GQ+IQ VSA D+D GQ F + L+PEAA PNFT+RD
Sbjct: 489 DNAPEFPRFYEAFVCENAKAGQLIQTVSAVDQDDPRNGQHFYYSLAPEAANNPNFTIRDN 548
Query: 544 RNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRVCRCDSDGTILSCNV 603
++NTA I TRR+G+ +++Q ++ LP++I DS PV SST T+TI+VC CD DG ++SC+
Sbjct: 549 QDNTARILTRRSGFRQQEQSVFHLPILIADSGQPVLSSTGTLTIQVCSCDDDGHVMSCSP 608
Query: 604 EAIFLPVGLSTGALIAILLCIVILLAIVVLYVALRRQKKKDTLMTSKEDIRDNVIHYDDE 663
EA LPV LS GALIAIL CI +LL +V+L +++RR +K+ ++ +E+I +N++ YDDE
Sbjct: 609 EAYMLPVSLSRGALIAILACIFVLLVLVLLILSMRRHRKQPYIIDDEENIHENIVRYDDE 668
Query: 664 GGGEEDTQAFDIGALRNPKVIEEN---KIRRDIKPDSLCLPRQRP-PMEDNTDIRDFIHQ 719
GGGEEDT+AFDI A+ NP+ + K R+D+ P+ L R P N+ + ++
Sbjct: 669 GGGEEDTEAFDIAAMWNPREAQAGAAPKTRQDMLPEIESLSRYVPQTCAVNSTVHSYVLA 728
Query: 720 RLQENDVDPTAPPYDSLATYAYEGSGSVAESLSSIDSLTTEADQDYDYLTDWGPRFKVLA 779
+L E D+D APP+DSL TY +EG GSVA SLSS+ S T++++Q +D+LTDWGPRF+ LA
Sbjct: 729 KLYEADMDLWAPPFDSLQTYMFEGDGSVAGSLSSLQSATSDSEQSFDFLTDWGPRFRKLA 788
Query: 780 DMFGEEESYNP 790
+++G E P
Sbjct: 789 ELYGASEGPAP 799
>gi|16753221 cadherin 22 precursor [Homo sapiens]
Length = 828
Score = 785 bits (2027), Expect = 0.0
Identities = 387/767 (50%), Positives = 538/767 (70%), Gaps = 30/767 (3%)
Query: 51 RVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGTVFTIDETTGD 110
RVKRGWVWNQFFV+EEY G+EP YVGK+HSD D+G+G +KYT+SG+GAGT+F IDE TGD
Sbjct: 59 RVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTISGEGAGTIFLIDELTGD 118
Query: 111 IHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPYVATVP 170
IHA+ LDRE+K FYTLRAQA D T + LEPESEFIIKVQDIND+EP+FL GPY+ +V
Sbjct: 119 IHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVA 178
Query: 171 EMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQPYFSIDPKTGVIRTALPNMDREVK 230
E+SP G V+QV A+DADDPTYG+SAR+VYS+L G+ +F++DPKTGVIRTA+P++DRE +
Sbjct: 179 ELSPTGTSVMQVMASDADDPTYGSSARLVYSVLDGEHHFTVDPKTGVIRTAVPDLDRESQ 238
Query: 231 EQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGR 290
E+Y+V+IQA DM GQLGGL+G+T V I +TDVNDNPPRFP+ ++ + ES+PIG+A+GR
Sbjct: 239 ERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGR 298
Query: 291 IRAVDPDFGQNAEIEYNI--VPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKV 348
++A D D G+N ++ Y++ GG++F + TD DTQE +I ++K LDFE++ +T +
Sbjct: 299 VKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVIL 358
Query: 349 EASNLHLDHRFHSAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTPVGTIIGAVTA 408
EA N +D RF G F+D A V+++V DVDEPP F P +EV ED VG+++G VTA
Sbjct: 359 EALNKFVDPRFADLGTFRDQAIVRVAVTDVDEPPEFRPPSGLLEVQEDAQVGSLVGVVTA 418
Query: 409 QDLDVGSSAVRYFIDWKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPL 468
+D D + VRY ID +SD D F ID + G I T + LDRE+ +N +++A + N
Sbjct: 419 RDPDAANRPVRYAIDRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHA 478
Query: 469 LTSKVNILINVLDVNEFPPEISVPYETAVCENAKPGQIIQIVSAADRDLSPAGQQFSFRL 528
S+ ++ I +LDVN+ PPE++ PYE AVCE+AKPGQ+IQ +S DRD G +F FRL
Sbjct: 479 QLSRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRL 538
Query: 529 SPEAAIKPNFTVRDFRNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIR 588
PEA P+F++ D ++NTA + T+ G++R++Q+++FLP+++ DS P SST T+TIR
Sbjct: 539 VPEAPSNPHFSLLDIQDNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIR 598
Query: 589 VCRCDSDGTILSCNVEAIFLPVGLSTGALIAILLCIVILLAIVVLYVALRRQKKKDTLMT 648
+C CDS GTI SCN A + LS GALIA+L+C++IL+ +V+L + LRR K
Sbjct: 599 ICGCDSSGTIQSCNTTAFVMAASLSPGALIALLVCVLILVVLVLLILTLRRHHKSHLSSD 658
Query: 649 SKEDIRDNVIHYDDEGGGEEDTQAFDIGALRNPKVIEENK-------------------- 688
ED+RDNVI Y+DEGGGE+DT+A+D+ ALR+ E K
Sbjct: 659 EDEDMRDNVIKYNDEGGGEQDTEAYDMSALRSLYDFGELKGGDGGGSAGGGAGGGSGGGA 718
Query: 689 ---IRRDIKPDSLCLPRQRP-PMEDNTDIRDFIHQRLQENDVDPTAPPYDSLATYAYEGS 744
+ + + LP+ P P D + RDFI +++ D D + PPYD+ TYA+EG+
Sbjct: 719 GSPPQAHLPSERHSLPQGPPSPEPDFSVFRDFISRKVALADGDLSVPPYDAFQTYAFEGA 778
Query: 745 GSVAESLSSIDSLTTEADQDYDYLTDWGPRFKVLADMF----GEEES 787
S A SLSS+ S ++ ++QD+ YL+ WGPRF+ LA ++ G++E+
Sbjct: 779 DSPAASLSSLHSGSSGSEQDFAYLSSWGPRFRPLAALYAGHRGDDEA 825
>gi|32880203 cadherin-like 24 isoform 2 [Homo sapiens]
Length = 781
Score = 727 bits (1876), Expect = 0.0
Identities = 375/759 (49%), Positives = 514/759 (67%), Gaps = 19/759 (2%)
Query: 44 GQRSH----FQRVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAG 99
G R H R +R WVWNQFFV+EEY G EP +GKLHSD+D+GEG KY L+G+GAG
Sbjct: 30 GSREHPGPALLRTRRSWVWNQFFVIEEYAGPEPVLIGKLHSDVDRGEGRTKYLLTGEGAG 89
Query: 100 TVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPK 159
TVF IDE TG+IH +SLDREEK Y L AQAVD + +PLEP SEFIIKVQDINDN P
Sbjct: 90 TVFVIDEATGNIHVTKSLDREEKAQYVLLAQAVDRASNRPLEPPSEFIIKVQDINDNPPI 149
Query: 160 FLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQPYFSIDPKTGVIR 219
F GPY ATVPEMS VG V+QV A DADDP+YGNSA++VY++L G P+FS+DP+TGV+R
Sbjct: 150 FPLGPYHATVPEMSNVGTSVIQVTAHDADDPSYGNSAKLVYTVLDGLPFFSVDPQTGVVR 209
Query: 220 TALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVP 279
TA+PNMDRE +E++ V+IQAKDMGG +GGL+G+T V +TL+DVNDNPP+FP+S++ V
Sbjct: 210 TAIPNMDRETQEEFLVVIQAKDMGGHMGGLSGSTTVTVTLSDVNDNPPKFPQSLYQFSVV 269
Query: 280 ESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFE 339
E++ G+ +GR+RA DPD G NA + Y+I+ G+G F I TD ++G++ ++KPLDFE
Sbjct: 270 ETAGPGTLVGRLRAQDPDLGDNALMAYSILDGEGSEAFSISTDLQGRDGLLTVRKPLDFE 329
Query: 340 TKKAYTFKVEASNLHLDHRFHSAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTPV 399
++++Y+F+VEA+N +D + GPFKD A+V+++V D EPP F++ Y + V E+
Sbjct: 330 SQRSYSFRVEATNTLIDPAYLRRGPFKDVASVRVAVQDAPEPPAFTQAAYHLTVPENKAP 389
Query: 400 GTIIGAVTAQDLDVGSSAVRYFIDWKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSI 459
GT++G ++A DLD +S +RY I SD + F+I EGTI T LDRE+ A +N ++
Sbjct: 390 GTLVGQISAADLDSPASPIRYSILPHSDPERCFSIQPEEGTIHTAAPLDREARAWHNLTV 449
Query: 460 IASKVSNPLLTSKVNILINVLDVNEFPPEISVPYETAVCENAKPGQIIQIVSAADRDLSP 519
+A+++ + S+V + I LD N+ P+++ PY+T VC++A PGQ+IQ++ A DRD
Sbjct: 450 LATELDSSAQASRVQVAIQTLDENDNAPQLAEPYDTFVCDSAAPGQLIQVIRALDRDEVG 509
Query: 520 AGQQFSFR--LSPEAAIKPNFTVRDFRNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYP 577
SF+ L P+A NFTV+D R+ +A + R Y +P+ + D P
Sbjct: 510 NSSHVSFQGPLGPDA----NFTVQDNRDGSASLLLPSRPAPPRHAP-YLVPIELWDWGQP 564
Query: 578 VQSSTNTMTIRVCRCDSDGTILSCNVEAIFLPVGLSTGALIAILLCIVILLAIVVLYVAL 637
SST T+T+ VCRC DG++ SC EA GLSTGAL+AI+ C+ LLA+VVL+VAL
Sbjct: 565 ALSSTATVTVSVCRCQPDGSVASCWPEAHLSAAGLSTGALLAIITCVGALLALVVLFVAL 624
Query: 638 RRQKKKDTLMTSKEDIRDNVIHYDDEGGGEEDTQAFDIGALRNP----KVIEENKIRRDI 693
RRQK++ ++ +ED+R+N+I YDDEGGGEEDT+AFDI AL+NP RRD+
Sbjct: 625 RRQKQEALMVLEEEDVRENIITYDDEGGGEEDTEAFDITALQNPDGAAPPAPGPPARRDV 684
Query: 694 KPDSLCLPRQRPPMEDNTDIRDFIHQRLQENDVDPTAPPYDSLATYAYEGSGSVAESLSS 753
P + + RPP D+ + RL+E D DP PPYDS+ Y YEG GS SLSS
Sbjct: 685 LPRARVSRQPRPP--GPADVAQLLALRLREADEDPGVPPYDSVQVYGYEGRGSSCGSLSS 742
Query: 754 IDSLTTE--ADQDYDYLTDWGPRFKVLADMFGEEESYNP 790
+ S + A + L DWGP F+ LA+++G +E P
Sbjct: 743 LGSGSEAGGAPGPAEPLDDWGPLFRTLAELYGAKEPPAP 781
>gi|32880206 cadherin-like 24 isoform 1 [Homo sapiens]
Length = 819
Score = 709 bits (1831), Expect = 0.0
Identities = 378/797 (47%), Positives = 516/797 (64%), Gaps = 57/797 (7%)
Query: 44 GQRSH----FQRVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAG 99
G R H R +R WVWNQFFV+EEY G EP +GKLHSD+D+GEG KY L+G+GAG
Sbjct: 30 GSREHPGPALLRTRRSWVWNQFFVIEEYAGPEPVLIGKLHSDVDRGEGRTKYLLTGEGAG 89
Query: 100 TVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPK 159
TVF IDE TG+IH +SLDREEK Y L AQAVD + +PLEP SEFIIKVQDINDN P
Sbjct: 90 TVFVIDEATGNIHVTKSLDREEKAQYVLLAQAVDRASNRPLEPPSEFIIKVQDINDNPPI 149
Query: 160 FLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQPYFSIDPKTGVIR 219
F GPY ATVPEMS VG V+QV A DADDP+YGNSA++VY++L G P+FS+DP+TGV+R
Sbjct: 150 FPLGPYHATVPEMSNVGTSVIQVTAHDADDPSYGNSAKLVYTVLDGLPFFSVDPQTGVVR 209
Query: 220 TALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVP 279
TA+PNMDRE +E++ V+IQAKDMGG +GGL+G+T V +TL+DVNDNPP+FP+S++ V
Sbjct: 210 TAIPNMDRETQEEFLVVIQAKDMGGHMGGLSGSTTVTVTLSDVNDNPPKFPQSLYQFSVV 269
Query: 280 ESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFE 339
E++ G+ +GR+RA DPD G NA + Y+I+ G+G F I TD ++G++ ++KPLDFE
Sbjct: 270 ETAGPGTLVGRLRAQDPDLGDNALMAYSILDGEGSEAFSISTDLQGRDGLLTVRKPLDFE 329
Query: 340 TKKAYTFKVEASNLHLDHRFHSAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTPV 399
++++Y+F+VEA+N +D + GPFKD A+V+++V D EPP F++ Y + V E+
Sbjct: 330 SQRSYSFRVEATNTLIDPAYLRRGPFKDVASVRVAVQDAPEPPAFTQAAYHLTVPENKAP 389
Query: 400 GTIIGAVTAQDLDVGSSAVRYFIDWKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSI 459
GT++G ++A DLD +S +RY I SD + F+I EGTI T LDRE+ A +N ++
Sbjct: 390 GTLVGQISAADLDSPASPIRYSILPHSDPERCFSIQPEEGTIHTAAPLDREARAWHNLTV 449
Query: 460 IASKVS---------NPLL-----------------------------TSKVNILINVLD 481
+A+++ PLL S+V + I LD
Sbjct: 450 LATELGWSWGPERGWVPLLVAEWSAPAAPPQRSPVGSAVGIPQDSSAQASRVQVAIQTLD 509
Query: 482 VNEFPPEISVPYETAVCENAKPGQIIQIVSAADRDLSPAGQQFSFR--LSPEAAIKPNFT 539
N+ P+++ PY+T VC++A PGQ+IQ++ A DRD SF+ L P+A NFT
Sbjct: 510 ENDNAPQLAEPYDTFVCDSAAPGQLIQVIRALDRDEVGNSSHVSFQGPLGPDA----NFT 565
Query: 540 VRDFRNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRVCRCDSDGTIL 599
V+D R+ +A + R Y +P+ + D P SST T+T+ VCRC DG++
Sbjct: 566 VQDNRDGSASLLLPSRPAPPRHAP-YLVPIELWDWGQPALSSTATVTVSVCRCQPDGSVA 624
Query: 600 SCNVEAIFLPVGLSTGALIAILLCIVILLAIVVLYVALRRQKKKDTLMTSKEDIRDNVIH 659
SC EA GLSTGAL+AI+ C+ LLA+VVL+VALRRQK++ ++ +ED+R+N+I
Sbjct: 625 SCWPEAHLSAAGLSTGALLAIITCVGALLALVVLFVALRRQKQEALMVLEEEDVRENIIT 684
Query: 660 YDDEGGGEEDTQAFDIGALRNP----KVIEENKIRRDIKPDSLCLPRQRPPMEDNTDIRD 715
YDDEGGGEEDT+AFDI AL+NP RRD+ P + + RPP D+
Sbjct: 685 YDDEGGGEEDTEAFDITALQNPDGAAPPAPGPPARRDVLPRARVSRQPRPP--GPADVAQ 742
Query: 716 FIHQRLQENDVDPTAPPYDSLATYAYEGSGSVAESLSSIDSLTTE--ADQDYDYLTDWGP 773
+ RL+E D DP PPYDS+ Y YEG GS SLSS+ S + A + L DWGP
Sbjct: 743 LLALRLREADEDPGVPPYDSVQVYGYEGRGSSCGSLSSLGSGSEAGGAPGPAEPLDDWGP 802
Query: 774 RFKVLADMFGEEESYNP 790
F+ LA+++G +E P
Sbjct: 803 LFRTLAELYGAKEPPAP 819
>gi|12656655 cadherin 19, type 2 preproprotein [Homo sapiens]
Length = 772
Score = 691 bits (1783), Expect = 0.0
Identities = 362/745 (48%), Positives = 494/745 (66%), Gaps = 10/745 (1%)
Query: 46 RSHFQRVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGTVFTID 105
RSH RVKRGWVWNQFFV EE + + ++G+L SDLD G + +Y L G GAG+ F ID
Sbjct: 36 RSHL-RVKRGWVWNQFFVPEE-MNTTSHHIGQLRSDLDNGNNSFQYKLLGAGAGSTFIID 93
Query: 106 ETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPY 165
E TGDI+AI+ LDREE+ Y LRAQ +DI T + +EPESEF+IKV DINDNEPKFLD PY
Sbjct: 94 ERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFLDEPY 153
Query: 166 VATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQPYFSIDPKTGVIRTALPNM 225
A VPEMSP G V+QV A+DADDP+ GN+AR++YS+LQGQPYFS++P TGVIR + M
Sbjct: 154 EAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQPYFSVEPTTGVIRIS-SKM 212
Query: 226 DREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIG 285
DRE++++Y V+IQAKDM GQ G L+GTT V I L+DVNDN P F +S++ L V ES+P G
Sbjct: 213 DRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTG 272
Query: 286 SAIGRIRAVDPDFGQNAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYT 345
++IG I A D D G+NAE++Y+I D FDI+T+ +TQEG++ LKK +DFE + Y
Sbjct: 273 TSIGTIMAYDNDIGENAEMDYSIEEDDS-QTFDIITNHETQEGIVILKKKVDFEHQNHYG 331
Query: 346 FKVEASNLHLDHRFHSAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTPVGTIIGA 405
+ + N H+ + T +KI V DVDEPP+F P Y EV+E+TP G+ +G
Sbjct: 332 IRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPLFLLPYYVFEVFEETPQGSFVGV 391
Query: 406 VTAQDLDVGSSAVRYFIDWKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVS 465
V+A D D S +RY I F I+ N GTI T+ LDRE +A YN SI A++
Sbjct: 392 VSATDPDNRKSPIRYSIT----RSKVFNINDN-GTITTSNSLDREISAWYNLSITATEKY 446
Query: 466 NPLLTSKVNILINVLDVNEFPPEISVPYETAVCENAKPGQIIQIVSAADRDLSPAGQQFS 525
N S + + + VL++N+ PE S YET VCENA GQ+IQ +SA DRD S F
Sbjct: 447 NIEQISSIPLYVQVLNINDHAPEFSQYYETYVCENAGSGQVIQTISAVDRDESIEEHHFY 506
Query: 526 FRLSPEAAIKPNFTVRDFRNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTM 585
F LS E +FT+ D ++NTA I T R G++ +++ ++++ ++I D+ P +STNT+
Sbjct: 507 FNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGIPSLTSTNTL 566
Query: 586 TIRVCRCDSDGTILSCNVEAIFLPVGLSTGALIAILLCIVILLAIVVLYVALRRQKKKDT 645
TI VC C G+ +C + + L +G T +IAIL+CI+I+ + L + L++++K+
Sbjct: 567 TIHVCDCGDSGSTQTCQYQELVLSMGFKTEVIIAILICIMIIFGFIFLTLGLKQRRKQIL 626
Query: 646 LMTSKEDIRDNVIHYDDEGGGEEDTQAFDIGALRNPKVIEENKIRRDIKPDSLCLPRQRP 705
ED R+N+ YDDEGGGEEDT+AFDI LR+ ++ E K R+ + L RQ
Sbjct: 627 FPEKSEDFRENIFQYDDEGGGEEDTEAFDIAELRSSTIMRERKTRKTTSAEIRSLYRQSL 686
Query: 706 PM-EDNTDIRDFIHQRLQENDVDPTAPPYDSLATYAYEGSGSVAESLSSIDSLTTEADQD 764
+ D+ R FI ++L+E + DP APP+DSL TYA+EG+GS+A SLSS++S ++ D+
Sbjct: 687 QVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTYAFEGTGSLAGSLSSLESAVSDQDES 746
Query: 765 YDYLTDWGPRFKVLADMFGEEESYN 789
YDYL + GPRFK LA MFG N
Sbjct: 747 YDYLNELGPRFKRLACMFGSAVQSN 771
>gi|166362713 cadherin 5, type 2 preproprotein [Homo sapiens]
Length = 784
Score = 499 bits (1284), Expect = e-141
Identities = 298/758 (39%), Positives = 440/758 (58%), Gaps = 45/758 (5%)
Query: 50 QRVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGTVFTIDETTG 109
+R KR W+WNQ + EE S P +VGK+ S + + KY L G+ G VF +D TG
Sbjct: 43 RRQKRDWIWNQMHIDEEKNTSLPHHVGKIKSSVSRKNA--KYLLKGEYVGKVFRVDAETG 100
Query: 110 DIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPYVATV 169
D+ AI LDRE Y L A VD +T + LE S F IKV D+NDN P F + A+V
Sbjct: 101 DVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASV 160
Query: 170 PEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQPYFSIDPKTGVIRTALPNMDREV 229
PE S VG V+ V A DADDPT G+ A V+Y IL+G+ YF+ID +G I T ++DRE
Sbjct: 161 PESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKEYFAID-NSGRIITITKSLDREK 219
Query: 230 KEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIG 289
+ +Y+++++A+D G L G +GT V +TL D+NDN P F ++ + VPE + +G+++G
Sbjct: 220 QARYEIVVEARDAQG-LRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVG 278
Query: 290 RIRAVDPDFGQNAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVE 349
+ DPD QN +Y+I+ GD + F I T+ EG+IK KPLD+E + Y+F VE
Sbjct: 279 SLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVE 338
Query: 350 ASNLHLDHRFHSAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQ 409
A++ +D R+ S P + A V I++ DVDEPP+F +P Y ++ E+ +IG V A
Sbjct: 339 ATDPTIDLRYMSP-PAGNRAQVIINITDVDEPPIFQQPFYHFQLKENQK-KPLIGTVLAM 396
Query: 410 DLDVGSSAVRYFIDWKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKV-SNPL 468
D D ++ Y I SD +F + +G I + LDRE YN ++ A ++ S
Sbjct: 397 DPDAARHSIGYSIRRTSDKGQFFRVT-KKGDIYNEKELDREVYPWYNLTVEAKELDSTGT 455
Query: 469 LTSK---VNILINVLDVNEFPPEISVPYETAVCENAKPGQIIQIVSAADRDLSPAGQQFS 525
T K V + I VLD N+ PE + PY+ VCENA GQ++ +SA D+D++P +F
Sbjct: 456 PTGKESIVQVHIEVLDENDNAPEFAKPYQPKVCENAVHGQLVLQISAIDKDITPRNVKFK 515
Query: 526 FRLSPEAAIKPNFTVRDFRNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTM 585
F L+ E NFT+ D +NTA I + + R +++FLPVVI D+ P ++ T+T+
Sbjct: 516 FILNTE----NNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTL 571
Query: 586 TIRVCRCDSDGTILSCNVEAIFLPVGLSTGALIAILLCIVILLAIVVLYVALRRQKKKDT 645
T+ VC+C+ G C E + VG+S A++AILLCI + + ++ L + LRR+ +K
Sbjct: 572 TVAVCKCNEQGEFTFC--EDMAAQVGVSIQAVVAILLCI-LTITVITLLIFLRRRLRKQA 628
Query: 646 LMTSKE--DIRDNVIHYDDEGGGEEDTQAFDIGALRNPKVIEENKIRR----------DI 693
K +I + ++ YD+EGGGE DT ++D+ L N +RR D
Sbjct: 629 RAHGKSVPEIHEQLVTYDEEGGGEMDTTSYDVSVL--------NSVRRGGAKPPRPALDA 680
Query: 694 KPDSLCLPRQRPPME------DNTDIRDFIHQRLQENDVDPTAPPYDSLATYAYEGSGSV 747
+P SL Q+PP ++ I + E D D PPYD+L Y YEGS S+
Sbjct: 681 RP-SLYAQVQKPPRHAPGAHGGPGEMAAMIEVKKDEADHDGDGPPYDTLHIYGYEGSESI 739
Query: 748 AESLSSIDSLTTEADQDYDYLTDWGPRFKVLADMFGEE 785
AESLSS+ + ++++D DYD+L DWGPRFK+LA+++G +
Sbjct: 740 AESLSSLGTDSSDSDVDYDFLNDWGPRFKMLAELYGSD 777
>gi|14589893 cadherin 4, type 1 preproprotein [Homo sapiens]
Length = 916
Score = 419 bits (1077), Expect = e-117
Identities = 289/792 (36%), Positives = 426/792 (53%), Gaps = 53/792 (6%)
Query: 25 PQPQQTLATEPRENVIHLPGQRSHFQRVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDK 84
P P+ TL P+ + +R KR WV V E G PQ + ++ SD D
Sbjct: 146 PPPKDTLLPWPQHQ------NANGLRRRKRDWVIPPINVPENSRGPFPQQLVRIRSDKDN 199
Query: 85 GEGTVKYTLSGDGAGT----VFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPL 140
+ ++Y+++G GA VF+ID +G ++ R +DREE Y LRA AVD+ K +
Sbjct: 200 -DIPIRYSITGVGADQPPMEVFSIDSMSGRMYVTRPMDREEHASYHLRAHAVDMNGNK-V 257
Query: 141 EPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSA---R 197
E + I V D+NDN P+F++ Y +V E S G YV+ V A DADD T N R
Sbjct: 258 ENPIDLYIYVIDMNDNRPEFINQVYNGSVDEGSKPGTYVMTVTANDADDSTTANGMVRYR 317
Query: 198 VVYSILQG--QPYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLG-GLAGTTI 254
+V Q Q F+I+ +TG I T +DRE +QY V++QA DM G L GL+ T
Sbjct: 318 IVTQTPQSPSQNMFTINSETGDIVTVAAGLDREKVQQYTVIVQATDMEGNLNYGLSNTAT 377
Query: 255 VNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPD--FGQNAEIEYNIVPGD 312
IT+TDVNDNPP F S F +VPE+ + + + + +D D N Y I+ GD
Sbjct: 378 AIITVTDVNDNPPEFTASTFAGEVPENR-VETVVANLTVMDRDQPHSPNWNAVYRIISGD 436
Query: 313 GGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTATVK 372
F + TD T EG++ + K +D+E +A+ V SN F+ TA V
Sbjct: 437 PSGHFSVRTDPVTNEGMVTVVKAVDYELNRAFMLTVMVSN-QAPLASGIQMSFQSTAGVT 495
Query: 373 ISVLDVDEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLD-VGSSAVRYFIDWKSDGDSY 431
IS++D++E P F + + E P GT++ +A D D AVRY SD S+
Sbjct: 496 ISIMDINEAPYFPSNHKLIRLEEGVPPGTVLTTFSAVDPDRFMQQAVRY--SKLSDPASW 553
Query: 432 FTIDGNEGTIATNELLDRESTAQ----YNFSIIASKVSNPLLTSKVNILINVLDVNEFPP 487
I+ G I T +LDRES Y + +A+ P + + I ++D+N+ P
Sbjct: 554 LHINATNGQITTAAVLDRESLYTKNNVYEATFLAADNGIPPASGTGTLQIYLIDINDNAP 613
Query: 488 EISVPYETAVCENAKPGQIIQIVSAADRDLSPAGQQFSFRLS-PEAAIKPNFTVRDFRNN 546
E+ +P E +CE KP ++AAD D+ P + F L AA++ N+T+ +
Sbjct: 614 EL-LPKEAQICE--KPNLNAINITAADADVDPNIGPYVFELPFVPAAVRKNWTITRLNGD 670
Query: 547 TAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRVCRCDSDGTILSCNVEAI 606
A + R + +Y +P+++ DS P S+T+ + ++VC CD +G C
Sbjct: 671 YAQLSLR---ILYLEAGMYDVPIIVTDSGNPPLSNTSIIKVKVCPCDDNG---DCTTIGA 724
Query: 607 FLPVGLSTGALIAILLCIVILLAIVVLYVAL--RRQKKKDT---LMTSKEDIRDNVIHYD 661
GL TGA++AIL+CI+ILL +V+L+V RR+K++ T L+ ++D+RDN++ YD
Sbjct: 725 VAAAGLGTGAIVAILICILILLTMVLLFVMWMKRREKERHTKQLLIDPEDDVRDNILKYD 784
Query: 662 DEGGGEEDTQAFDIGALRNPKVI-----EENKIRRDIKPDSLCLPRQ--RPPMEDNTDIR 714
+EGGGEED Q +D+ L+ P+ + + +RR + P+ RP + DI
Sbjct: 785 EEGGGEED-QDYDLSQLQQPEAMGHVPSKAPGVRRVDERPVGAEPQYPIRPMVPHPGDIG 843
Query: 715 DFIHQRLQENDVDPTAPPYDSLATYAYEGSGSVAESLSSIDSLTTEADQDYDYLTDWGPR 774
DFI++ L+ D DPTAPPYDSL + YEGSGS A S+SS++S ++ DQDYDYL DWGPR
Sbjct: 844 DFINEGLRAADNDPTAPPYDSLLVFDYEGSGSTAGSVSSLNS-SSSGDQDYDYLNDWGPR 902
Query: 775 FKVLADMFGEEE 786
FK LADM+G E
Sbjct: 903 FKKLADMYGGGE 914
>gi|14589889 cadherin 2, type 1 preproprotein [Homo sapiens]
Length = 906
Score = 419 bits (1076), Expect = e-117
Identities = 284/772 (36%), Positives = 418/772 (54%), Gaps = 58/772 (7%)
Query: 48 HFQRVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGT----VFT 103
H QR KR WV + E G PQ + ++ SD DK +++Y+++G GA +F
Sbjct: 153 HLQRQKRDWVIPPINLPENSRGPFPQELVRIRSDRDKNL-SLRYSVTGPGADQPPTGIFI 211
Query: 104 IDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDG 163
I+ +G + + LDRE+ + LRA AVDI + +E + +I V D+NDN P+FL
Sbjct: 212 INPISGQLSVTKPLDREQIARFHLRAHAVDINGNQ-VENPIDIVINVIDMNDNRPEFLHQ 270
Query: 164 PYVATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQP------YFSIDPKTGV 217
+ TVPE S G YV+ V A DADDP N + Y I+ P F+I+ +TG
Sbjct: 271 VWNGTVPEGSKPGTYVMTVTAIDADDPNALNGM-LRYRIVSQAPSTPSPNMFTINNETGD 329
Query: 218 IRTALPNMDREVKEQYQVLIQAKDM-GGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHL 276
I T +DRE +QY ++IQA DM G GL+ T IT+TDVNDNPP F F+
Sbjct: 330 IITVAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYG 389
Query: 277 KVPESSPIGSAIGRIRAVDPDFGQNA--EIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKK 334
+VPE+ + + + D D Y I GD F I TD ++ +G++ + K
Sbjct: 390 EVPENR-VDIIVANLTVTDKDQPHTPAWNAVYRISGGDPTGRFAIQTDPNSNDGLVTVVK 448
Query: 335 PLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVY 394
P+DFET + + V A N + P + TATV ++V+DV+E P F+ +
Sbjct: 449 PIDFETNRMFVLTVAAEN-QVPLAKGIQHPPQSTATVSVTVIDVNENPYFAPNPKIIRQE 507
Query: 395 EDTPVGTIIGAVTAQDLD-VGSSAVRYFIDWKSDGDSYFTIDGNEGTIATNELLDRESTA 453
E GT++ TAQD D +RY SD ++ ID G I T +LDRES
Sbjct: 508 EGLHAGTMLTTFTAQDPDRYMQQNIRY--TKLSDPANWLKIDPVNGQITTIAVLDRESPN 565
Query: 454 Q----YNFSIIASKVSNPLLTSKVNILINVLDVNEFPPEISVPYETAVCENAKPGQIIQI 509
YN + +AS P ++ + I +LD+N+ P++ +P E CE P I
Sbjct: 566 VKNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQV-LPQEAETCETPDPNSIN-- 622
Query: 510 VSAADRDLSPAGQQFSFRL--SPEAAIKPNFTVRDFRNNTAGIETRRNGYSRRQQELYFL 567
++A D D+ P F+F L SP IK N+T+ + A + + + +Y +
Sbjct: 623 ITALDYDIDPNAGPFAFDLPLSP-VTIKRNWTITRLNGDFAQLNLK---IKFLEAGIYEV 678
Query: 568 PVVIEDSSYPVQSSTNTMTIRVCRCDSDGTILSCNVEAIFLPVGLSTGALIAILLCIVIL 627
P++I DS P +S+ + + ++VC+CDS+G C + GL TGA+IAILLCI+IL
Sbjct: 679 PIIITDSGNPPKSNISILRVKVCQCDSNG---DCTDVDRIVGAGLGTGAIIAILLCIIIL 735
Query: 628 LAIVVLYVALRRQKKKDT-----LMTSKEDIRDNVIHYDDEGGGEEDTQAFDIGALRNPK 682
L +V+++V +++ K+ L+ ++D+RDN++ YD+EGGGEED Q +D+ L+ P
Sbjct: 736 LILVLMFVVWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEED-QDYDLSQLQQPD 794
Query: 683 VIEENKIRRDIKPDSLCLPRQRP-------PMEDNT----DIRDFIHQRLQENDVDPTAP 731
+E + I KP + +RP P+ DI DFI++ L+ D DPTAP
Sbjct: 795 TVEPDAI----KPVGIRRMDERPIHAEPQYPVRSAAPHPGDIGDFINEGLKAADNDPTAP 850
Query: 732 PYDSLATYAYEGSGSVAESLSSIDSLTTEADQDYDYLTDWGPRFKVLADMFG 783
PYDSL + YEGSGS A SLSS++S ++ +QDYDYL DWGPRFK LADM+G
Sbjct: 851 PYDSLLVFDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRFKKLADMYG 902
>gi|4826669 cadherin 15 preproprotein [Homo sapiens]
Length = 814
Score = 374 bits (960), Expect = e-103
Identities = 264/755 (34%), Positives = 380/755 (50%), Gaps = 37/755 (4%)
Query: 51 RVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGT----VFTIDE 106
RV+R WV V E + P + ++ SD + G+V Y++ G G VF+ID+
Sbjct: 42 RVRRAWVIPPISVSENHKRL-PYPLVQIKSDKQQ-LGSVIYSIQGPGVDEEPRGVFSIDK 99
Query: 107 TTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPYV 166
TG + LDRE+ + LRA A+D+ LE ++ I V D NDN P FL +
Sbjct: 100 FTGKVFLNAMLDREKTDRFRLRAFALDLGG-STLEDPTDLEIVVVDQNDNRPAFLQEAFT 158
Query: 167 ATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQP-YFSIDPKTGVIRTALPNM 225
V E + G YV + +ATDADDP N+A + QG P FSID TG IRT +
Sbjct: 159 GRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQGSPELFSIDELTGEIRTVQVGL 218
Query: 226 DREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIG 285
DREV Y + +Q DM G GL T ITL D+NDN P F + F ++ E+ G
Sbjct: 219 DREVVAVYNLTLQVADMSGD--GLTATASAIITLDDINDNAPEFTRDEFFMEAIEAVS-G 275
Query: 286 SAIGRIRAVDPDF--GQNAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKA 343
+GR+ D D N + I+ GD F I TD T EGV+ + K LD+E+ +
Sbjct: 276 VDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYESCEH 335
Query: 344 YTFKVEASNLHLDHRFHSAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTPVGTII 403
Y KV N + + + A V++ V D +EPPVF + + E P GT++
Sbjct: 336 YELKVSVQN-EAPLQAAALRAERGQAKVRVHVQDTNEPPVFQENPLRTSLAEGAPPGTLV 394
Query: 404 GAVTAQDLDVGS-SAVRYFIDWKSDGDSYFTIDGNEGTIATNELLDREST----AQYNFS 458
+A+D D + Y D+ D + + +D G I T +L S Y
Sbjct: 395 ATFSARDPDTEQLQRLSYSKDY--DPEDWLQVDAATGRIQTQHVLSPASPFLKGGWYRAI 452
Query: 459 IIASKVSNPLLTSKVNILINVLDVNEFPPEISVPYETAVCENAKPGQIIQIVSAADRDLS 518
++A ++ T+ + I +L+VN+ P ++ P ++C G + ++ A D DL
Sbjct: 453 VLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGL-LLGATDEDLP 511
Query: 519 PAGQQFSFRLSPEAA-IKPNFTVRDFRNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYP 577
P G F F+LSP + N+++ + A + R + + L+ L +++ DS P
Sbjct: 512 PHGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPRH----QVPEGLHRLSLLLRDSGQP 567
Query: 578 VQSSTNTMTIRVCRCDSDGTILSCNVEAIFLPVGLSTGALIAILLCIVILLAIVVLYVAL 637
Q + + VCRC DG L + GLS GAL+ I+L +LL ++VL VAL
Sbjct: 568 PQQREQPLNVTVCRCGKDGVCLPGAAALLAGGTGLSLGALV-IVLASALLLLVLVLLVAL 626
Query: 638 R-----RQKKKDTLMTSKEDIRDNVIHYDDEGGGEEDTQAFDIGALRNPKVIE----ENK 688
R + + K L ++D+RDNV++YD++GGGEED A+DI LR+P +
Sbjct: 627 RARFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGGEEDQDAYDISQLRHPTALSLPLGPPP 686
Query: 689 IRRDIKPDSLCLPRQRPPMEDNTDIRDFIHQRLQENDVDPTAPPYDSLATYAYEGSGSVA 748
+RRD L R DI DFI+ L+ D DP+ PPYD+ Y YEG GSVA
Sbjct: 687 LRRDAPQGRLHPQPPRVLPTSPLDIADFINDGLEAADSDPSVPPYDTALIYDYEGDGSVA 746
Query: 749 ESLSSIDSLTTEADQDYDYLTDWGPRFKVLADMFG 783
+LSSI S + DQDYDYL DWGPRF LADM+G
Sbjct: 747 GTLSSILSSQGDEDQDYDYLRDWGPRFARLADMYG 781
>gi|4757960 cadherin 1, type 1 preproprotein [Homo sapiens]
Length = 882
Score = 370 bits (951), Expect = e-102
Identities = 274/798 (34%), Positives = 400/798 (50%), Gaps = 76/798 (9%)
Query: 24 QPQPQQTLATEPRENVIHLPGQRSHFQRVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLD 83
+P P Q + + ++ P +R KR WV E G P+ + ++ S+ D
Sbjct: 124 RPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKD 183
Query: 84 KGEGTVKYTLSGDGAGT----VFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKP 139
K EG V Y+++G GA T VF I+ TG + LDRE YTL + AV
Sbjct: 184 K-EGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVS-SNGNA 241
Query: 140 LEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARVV 199
+E E +I V D NDN+P+F + +V E + G V++V ATDADD +A +
Sbjct: 242 VEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAIA 301
Query: 200 YSILQGQP------YFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTT 253
Y+IL P F+I+ TGVI +DRE Y +++QA D+ G+ GL+ T
Sbjct: 302 YTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGE--GLSTTA 359
Query: 254 IVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNA--EIEYNIVPG 311
IT+TD NDNPP F + + +VPE+ I ++ D D E Y I+
Sbjct: 360 TAVITVTDTNDNPPIFNPTTYKGQVPENEA-NVVITTLKVTDADAPNTPAWEAVYTILND 418
Query: 312 DGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFK----- 366
DGG F + T+ +G++K K LDFE K+ Y V +N+ PF+
Sbjct: 419 DGGQ-FVVTTNPVNNDGILKTAKGLDFEAKQQYILHVAVTNVV---------PFEVSLTT 468
Query: 367 DTATVKISVLDVDEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRYFIDWKS 426
TATV + VLDV+E P+F P +EV ED VG I + TAQ+ D + W+
Sbjct: 469 STATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWR- 527
Query: 427 DGDSYFTIDGNEGTIATNELLDRES-----TAQYNFSIIASKVSNPLLTSKVNILINVLD 481
D ++ I+ + G I+T LDRE + Y IIA+ +P+ T +L+ + D
Sbjct: 528 DTANWLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGTLLLILSD 587
Query: 482 VNEFPPEISVPYETAVCE-NAKPGQIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNFTV 540
VN+ P I P CE N KP Q+++ D DL P F+ L+ A+ N+T+
Sbjct: 588 VNDNAP-IPEPRTIFFCERNPKP----QVINIIDADLPPNTSPFTAELTHGASA--NWTI 640
Query: 541 RDFRNNTAGIETRRNGYSRRQQELYFLP--VVIEDSSYPV-------QSSTNTMTIRVCR 591
+ Y+ QE L + +E Y + Q+ T+ V
Sbjct: 641 Q---------------YNDPTQESIILKPKMALEVGDYKINLKLMDNQNKDQVTTLEVSV 685
Query: 592 CDSDGTILSCNVEAIFLPVGLSTGALIAIL---LCIVILLAIVVLYVALRRQKKKDTLMT 648
CD +G C +A + GL A++ IL L ++IL+ +++L++ RR K+ L+
Sbjct: 686 CDCEGAAGVCR-KAQPVEAGLQIPAILGILGGILALLILILLLLLFLR-RRAVVKEPLLP 743
Query: 649 SKEDIRDNVIHYDDEGGGEEDTQAFDIGALRNPKVIEENKIRRDIKPDSLCLPRQRPPME 708
++D RDNV +YD+EGGGEED Q FD+ L R D+ P + +PR P
Sbjct: 744 PEDDTRDNVYYYDEEGGGEED-QDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPA 802
Query: 709 DNTDIRDFIHQRLQENDVDPTAPPYDSLATYAYEGSGSVAESLSSIDSLTTEADQDYDYL 768
+ +I +FI + L+ D DPTAPPYDSL + YEGSGS A SLSS++S ++ DQDYDYL
Sbjct: 803 NPDEIGNFIDENLKAADTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYL 862
Query: 769 TDWGPRFKVLADMFGEEE 786
+WG RFK LADM+G E
Sbjct: 863 NEWGNRFKKLADMYGGGE 880
>gi|14589891 cadherin 3, type 1 preproprotein [Homo sapiens]
Length = 829
Score = 341 bits (874), Expect = 2e-93
Identities = 255/785 (32%), Positives = 386/785 (49%), Gaps = 65/785 (8%)
Query: 28 QQTLATEPRENVIHLPGQRSHFQRVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDKGEG 87
Q+ + + R + P +R +R KR WV V E G PQ + +L S+ D+ +
Sbjct: 82 QERRSLKERNPLKIFPSKRI-LRRHKRDWVVAPISVPENGKGPFPQRLNQLKSNKDR-DT 139
Query: 88 TVKYTLSGDGAGT----VFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPE 143
+ Y+++G GA + VF +++ TG + + LDREE Y L AV E +E
Sbjct: 140 KIFYSITGPGADSPPEGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVS-ENGASVEDP 198
Query: 144 SEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSIL 203
I V D ND++PKF + +V E G V+QV ATD DD Y + V YSI
Sbjct: 199 MNISIIVTDQNDHKPKFTQDTFRGSVLEGVLPGTSVMQVTATDEDDAIYTYNGVVAYSIH 258
Query: 204 QGQP------YFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNI 257
+P F+I TG I +DRE +Y + IQA DM G G T + +
Sbjct: 259 SQEPKDPHDLMFTIHRSTGTISVISSGLDREKVPEYTLTIQATDMDGD--GSTTTAVAVV 316
Query: 258 TLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNA--EIEYNIVPGDGGN 315
+ D NDN P F + VPE++ +G + R+ D D + Y I+ GD G+
Sbjct: 317 EILDANDNAPMFDPQKYEAHVPENA-VGHEVQRLTVTDLDAPNSPAWRATYLIMGGDDGD 375
Query: 316 LFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPF-----KDTAT 370
F I T ++ +G++ +K LDFE K +T VE +N PF TAT
Sbjct: 376 HFTITTHPESNQGILTTRKGLDFEAKNQHTLYVEVTN---------EAPFVLKLPTSTAT 426
Query: 371 VKISVLDVDEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRYFIDWKSDGDS 430
+ + V DV+E PVF P +EV E P G + TA+D D + + Y I D
Sbjct: 427 IVVHVEDVNEAPVFVPPSKVVEVQEGIPTGEPVCVYTAEDPDKENQKISYRI--LRDPAG 484
Query: 431 YFTIDGNEGTIATNELLDRESTAQ-----YNFSIIASKVSNPLLTSKVNILINVLDVNEF 485
+ +D + G + LDRE Y ++A +P T +L+ ++DVN+
Sbjct: 485 WLAMDPDSGQVTAVGTLDREDEQFVRNNIYEVMVLAMDNGSPPTTGTGTLLLTLIDVNDH 544
Query: 486 PPEISVPYETAVCENAKPGQIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNFTVRDFRN 545
P + P + +C + Q++ I D+DLSP F +L+ ++ I V +
Sbjct: 545 GP-VPEPRQITICNQSPVRQVLNIT---DKDLSPHTSPFQAQLTDDSDIYWTAEVNE-EG 599
Query: 546 NTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRVCRCDSDGTILSCNVE- 604
+T + ++ +Q+ Y + + + D Q + IR CD G + +C
Sbjct: 600 DTVVLSLKKF----LKQDTYDVHLSLSDHGNKEQLTV----IRATVCDCHGHVETCPGPW 651
Query: 605 --AIFLPVGLSTGALIAILLCIVILLAIVVLYVALRRQKKKDTLMTSKEDIRDNVIHYDD 662
LPV GA++A+L +++LL +V +++K K+ L+ ++D RDNV +Y +
Sbjct: 652 KGGFILPV---LGAVLALLFLLLVLLLLV-----RKKRKIKEPLLLPEDDTRDNVFYYGE 703
Query: 663 EGGGEEDTQAFDIGAL-RNPKVIEENKIRRDIKPDSLCLPRQRPPMEDNTDIRDFIHQRL 721
EGGGEED Q +DI L R + E +R D+ P + P RP + +I +FI + L
Sbjct: 704 EGGGEED-QDYDITQLHRGLEARPEVVLRNDVAPTIIPTPMYRPRPANPDEIGNFIIENL 762
Query: 722 QENDVDPTAPPYDSLATYAYEGSGSVAESLSSIDSLTTEADQDYDYLTDWGPRFKVLADM 781
+ + DPTAPPYD+L + YEGSGS A SLSS+ S ++ DQDYDYL +WG RFK LADM
Sbjct: 763 KAANTDPTAPPYDTLLVFDYEGSGSDAASLSSLTSSASDQDQDYDYLNEWGSRFKKLADM 822
Query: 782 FGEEE 786
+G E
Sbjct: 823 YGGGE 827
>gi|4826702 desmocollin 1 isoform Dsc1b preproprotein [Homo sapiens]
Length = 840
Score = 245 bits (626), Expect = 1e-64
Identities = 202/642 (31%), Positives = 317/642 (49%), Gaps = 42/642 (6%)
Query: 50 QRVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAG----TVFTID 105
+R KR W ++E +G PQ+V ++ SD + T+ Y++SG G +F I+
Sbjct: 130 KRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNY-TIFYSISGPGVDKEPFNLFYIE 188
Query: 106 ETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPY 165
+ TGDI RS+DRE+ + L A + P P IIK++D NDN P F
Sbjct: 189 KDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYP-LPLIIKIEDDNDNAPYFEHRVT 247
Query: 166 VATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQP----YFSIDPKTGVIRTA 221
+ TVPE G V +V ATD D+P ++ R+ Y ILQ P +FSI P TGVI T
Sbjct: 248 IFTVPENCRSGTSVGKVTATDLDEPDTLHT-RLKYKILQQIPDHPKHFSIHPDTGVITTT 306
Query: 222 LPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPES 281
P +DRE + YQ++++ +DMGGQ GL T + I+L D NDNPP F ++ + +V E
Sbjct: 307 TPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEV-EE 365
Query: 282 SPIGSAIGRIRAVDPDFGQ--NAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFE 339
+ I I R++ D D +++ Y I+ G+ F I TD +T EGV+ + KPL++E
Sbjct: 366 NRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLNYE 425
Query: 340 TKKAYTFKVEASN-LHLDHRFHSAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTP 398
+ +V N S P T TV + ++D DE P P+ ++ + P
Sbjct: 426 VNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDGFP 485
Query: 399 VGTIIGAVTAQDLDVGS-SAVRYFIDWKSDGDSYFTIDGNEGTIATNELLDRES----TA 453
G + A D ++ S +RY D D++F I+ + G + T ++LDRES
Sbjct: 486 AGQELLGYKALDPEISSGEGLRY--QKLGDEDNWFEINQHTGDLRTLKVLDRESKFVKNN 543
Query: 454 QYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPEISVPYETAVCENAKPGQIIQIVSAA 513
QYN S++A T +++++ D N+ P+I E +C+N + ++
Sbjct: 544 QYNISVVAVDAVGRSCTG--TLVVHLDDYNDHAPQID--KEVTICQN---NEDFAVLKPV 596
Query: 514 DRDLSPAGQQFSFRLSPEAAIKPNFTVRDFRNNTAGIETRRNGYSRRQQELYFLPVVIED 573
D D G F F L A+ N+ + + TA + R+N Y +P+ I+D
Sbjct: 597 DPDGPENGPPFQFFLDNSAS--KNWNIEEKDGKTAILRQRQN----LDYNYYSVPIQIKD 650
Query: 574 SSYPVQSSTNTMTIRVCRCD--SDGTILSCNVEAIFLPVGLSTGALIAILLCIVILLAIV 631
V +T+ +T+RVC C S+ + + + V L A++A++L V+LL I
Sbjct: 651 RHGLV--ATHMLTVRVCDCSTPSECRMKDKSTRDVRPNVILGRWAILAMVLGSVLLLCI- 707
Query: 632 VLYVALRRQKKKDTLMTSKEDI-RDNVIHYDDEGGGEEDTQA 672
L+ K+ EDI + N+I + EG GEE T+A
Sbjct: 708 -LFTCFCVTAKRTVKKCFPEDIAQQNLIVSNTEGPGEEVTEA 748
>gi|13435361 desmocollin 1 isoform Dsc1a preproprotein [Homo
sapiens]
Length = 894
Score = 245 bits (626), Expect = 1e-64
Identities = 202/642 (31%), Positives = 317/642 (49%), Gaps = 42/642 (6%)
Query: 50 QRVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAG----TVFTID 105
+R KR W ++E +G PQ+V ++ SD + T+ Y++SG G +F I+
Sbjct: 130 KRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNY-TIFYSISGPGVDKEPFNLFYIE 188
Query: 106 ETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPY 165
+ TGDI RS+DRE+ + L A + P P IIK++D NDN P F
Sbjct: 189 KDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYP-LPLIIKIEDDNDNAPYFEHRVT 247
Query: 166 VATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQP----YFSIDPKTGVIRTA 221
+ TVPE G V +V ATD D+P ++ R+ Y ILQ P +FSI P TGVI T
Sbjct: 248 IFTVPENCRSGTSVGKVTATDLDEPDTLHT-RLKYKILQQIPDHPKHFSIHPDTGVITTT 306
Query: 222 LPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPES 281
P +DRE + YQ++++ +DMGGQ GL T + I+L D NDNPP F ++ + +V E
Sbjct: 307 TPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEV-EE 365
Query: 282 SPIGSAIGRIRAVDPDFGQ--NAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFE 339
+ I I R++ D D +++ Y I+ G+ F I TD +T EGV+ + KPL++E
Sbjct: 366 NRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLNYE 425
Query: 340 TKKAYTFKVEASN-LHLDHRFHSAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTP 398
+ +V N S P T TV + ++D DE P P+ ++ + P
Sbjct: 426 VNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDGFP 485
Query: 399 VGTIIGAVTAQDLDVGS-SAVRYFIDWKSDGDSYFTIDGNEGTIATNELLDRES----TA 453
G + A D ++ S +RY D D++F I+ + G + T ++LDRES
Sbjct: 486 AGQELLGYKALDPEISSGEGLRY--QKLGDEDNWFEINQHTGDLRTLKVLDRESKFVKNN 543
Query: 454 QYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPEISVPYETAVCENAKPGQIIQIVSAA 513
QYN S++A T +++++ D N+ P+I E +C+N + ++
Sbjct: 544 QYNISVVAVDAVGRSCTG--TLVVHLDDYNDHAPQID--KEVTICQN---NEDFAVLKPV 596
Query: 514 DRDLSPAGQQFSFRLSPEAAIKPNFTVRDFRNNTAGIETRRNGYSRRQQELYFLPVVIED 573
D D G F F L A+ N+ + + TA + R+N Y +P+ I+D
Sbjct: 597 DPDGPENGPPFQFFLDNSAS--KNWNIEEKDGKTAILRQRQN----LDYNYYSVPIQIKD 650
Query: 574 SSYPVQSSTNTMTIRVCRCD--SDGTILSCNVEAIFLPVGLSTGALIAILLCIVILLAIV 631
V +T+ +T+RVC C S+ + + + V L A++A++L V+LL I
Sbjct: 651 RHGLV--ATHMLTVRVCDCSTPSECRMKDKSTRDVRPNVILGRWAILAMVLGSVLLLCI- 707
Query: 632 VLYVALRRQKKKDTLMTSKEDI-RDNVIHYDDEGGGEEDTQA 672
L+ K+ EDI + N+I + EG GEE T+A
Sbjct: 708 -LFTCFCVTAKRTVKKCFPEDIAQQNLIVSNTEGPGEEVTEA 748
>gi|4502719 cadherin 13 preproprotein [Homo sapiens]
Length = 713
Score = 232 bits (592), Expect = 9e-61
Identities = 185/563 (32%), Positives = 272/563 (48%), Gaps = 36/563 (6%)
Query: 51 RVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGT----VFTIDE 106
R KR V + + E P+ VGK+ D D+ E + K+ L+G G +F I+E
Sbjct: 135 RQKRSIVVSPILIPENQRQPFPRDVGKV-VDSDRPERS-KFRLTGKGVDQEPKGIFRINE 192
Query: 107 TTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPYV 166
TG + R+LDRE Y L + D+ K LE + V D NDN P F +GPY+
Sbjct: 193 NTGSVSVTRTLDREVIAVYQLFVETTDVNG-KTLEGPVPLEVIVIDQNDNRPIFREGPYI 251
Query: 167 ATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQP------YFSIDPKTGVIRT 220
V E SP G V+++ A DADDP N A + Y+I Q P F IDP+ G I T
Sbjct: 252 GHVMEGSPTGTTVMRMTAFDADDPATDN-ALLRYNIRQQTPDKPSPNMFYIDPEKGDIVT 310
Query: 221 ALPN--MDREVKE--QYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHL 276
+ +DRE E +Y+++I+A+DM G GL GT I + D ND+ P+F K F
Sbjct: 311 VVSPALLDRETLENPKYELIIEAQDMAGLDVGLTGTATATIMIDDKNDHSPKFTKKEFQA 370
Query: 277 KVPESSPIGSAIGRIRAVDPDFGQNA--EIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKK 334
V E + I + D D Y I+ G+ G F+I T+ T EG++ + K
Sbjct: 371 TVEEGAV--GVIVNLTVEDKDDPTTGAWRAAYTIINGNPGQSFEIHTNPQTNEGMLSVVK 428
Query: 335 PLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVY 394
PLD+E +T ++ N S GP TATV I+VLDV+E PVF +
Sbjct: 429 PLDYEISAFHTLLIKVENEDPLVPDVSYGP-SSTATVHITVLDVNEGPVFYPDPMMVTRQ 487
Query: 395 EDTPVGTIIGAVTAQDLD-VGSSAVRYFIDWKSDGDSYFTIDGNEGTIATNELLDRES-- 451
ED VG+++ V A D D + +RY + D + I+ GT+ T +LDRES
Sbjct: 488 EDLSVGSVLLTVNATDPDSLQHQTIRYSV--YKDPAGWLNINPINGTVDTTAVLDRESPF 545
Query: 452 --TAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPEISVPYETAVCENAKPGQIIQI 509
+ Y +A NP T +LI + DVN+ P I P VC++AK ++ I
Sbjct: 546 VDNSVYTALFLAIDSGNPPATGTGTLLITLEDVNDNAPFI-YPTVAEVCDDAKNLSVV-I 603
Query: 510 VSAADRDLSPAGQQFSFRLSPEAAIKPNFTVRDFRNNTAGIETRRNGYSRRQQELYFLPV 569
+ A+D+DL P F F + +A + + N A + +N + Y LP+
Sbjct: 604 LGASDKDLHPNTDPFKFEIHKQAVPDKVWKISKINNTHALVSLLQN----LNKANYNLPI 659
Query: 570 VIEDSSYPVQSSTNTMTIRVCRC 592
++ DS P ++ + ++VC C
Sbjct: 660 MVTDSGKPPMTNITDLRVQVCSC 682
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 228 bits (580), Expect = 2e-59
Identities = 166/516 (32%), Positives = 255/516 (49%), Gaps = 28/516 (5%)
Query: 80 SDLDKG-EGTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRK 138
+DLD G G + Y +SG + F ID TG + + LDRE YTL D+ +
Sbjct: 742 TDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQ 801
Query: 139 PLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARV 198
++ V D NDN P+FL Y V E V + ++QV+ATD D G + V
Sbjct: 802 KAAWRLLHVVVV-DANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKD---LGPNGHV 857
Query: 199 VYSILQGQPYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNIT 258
YSI+ FSID TGV+ A P +DRE++ ++ + I+A+D + L T +V ++
Sbjct: 858 TYSIVTDTDTFSIDSVTGVVNIARP-LDRELQHEHSLKIEARDQAREEPQLFSTVVVKVS 916
Query: 259 LTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGGNLFD 318
L DVNDNPP F + +KV E P G+ I + A DPD GQ+ ++ Y+++ GN
Sbjct: 917 LEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNF-- 974
Query: 319 IVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTATVKISVLDV 378
D D G +++ + LDFE K+ Y V A + S T V++ V+DV
Sbjct: 975 ---DVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSS------TCYVEVEVVDV 1025
Query: 379 DE---PPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDV-GSSAVRYFIDWKSDGDSYFTI 434
+E PPVFS + V ED PVG+++ V+A D D +RY I G F I
Sbjct: 1026 NENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIR-DGSGVGVFKI 1084
Query: 435 DGNEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPEISVP-Y 493
G I T++ LDREST+ Y ++ A+ L+S + I I V DVN+ P+ S P Y
Sbjct: 1085 GEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVY 1144
Query: 494 ETAVCENAKPGQIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNFTVRDFRNNTAGIETR 553
+ EN+ + + A D D S + + ++++ + F++ T I T
Sbjct: 1145 YPEIMENSPKDVSVVQIEAFDPD-SSSNDKLMYKIT-SGNPQGFFSIHP---KTGLITTT 1199
Query: 554 RNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRV 589
R QQ+ + L V + D+ P +S+ + +++
Sbjct: 1200 SRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKI 1235
Score = 203 bits (517), Expect = 4e-52
Identities = 153/509 (30%), Positives = 247/509 (48%), Gaps = 29/509 (5%)
Query: 84 KGEGTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPE 143
+ + YTL G GA F ++ TG++ LDREE+ Y L +A D R +
Sbjct: 3053 RSNAEITYTLLGSGAEK-FKLNPDTGELKTSTPLDREEQAVYHLLVRATDGGGRFC---Q 3108
Query: 144 SEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSIL 203
+ ++ ++D+NDN P+F PY TV E + G + +V+ATDAD G + +++YS++
Sbjct: 3109 ASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADA---GLNRKILYSLI 3165
Query: 204 QGQP-YFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDV 262
FSI+ +G+I+ P +DRE++ Y + ++A D G L T V +++ D+
Sbjct: 3166 DSADGQFSINELSGIIQLEKP-LDRELQAVYTLSLKAVDQGLPRR-LTATGTVIVSVLDI 3223
Query: 263 NDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGGNLFDIVTD 322
NDNPP F + V E +G+ + ++ A D NAEI Y+I+ G+ F I
Sbjct: 3224 NDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSI--- 3280
Query: 323 EDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTATVKISVLDV-DEP 381
D++ G + + + LD+E+ Y VEA++ D ATV ++V D+ D
Sbjct: 3281 -DSKTGAVFIIENLDYESSHEYYLTVEATD-------GGTPSLSDVATVNVNVTDINDNT 3332
Query: 382 PVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRYFIDWKSDGDSYFTIDGNEGTI 441
PVFS+ YT + ED + + V A D D S++ ++ + S FTID G +
Sbjct: 3333 PVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEV 3392
Query: 442 ATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPEIS-VPYETAVCEN 500
+LLDRE+ + Y ++ AS +P + + I+V DVN+ P S Y + EN
Sbjct: 3393 KVTKLLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQEN 3452
Query: 501 AKPGQIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNFTVRDFRNNTAGIETRRNGYSRR 560
G + + D D S G F F I + F N G+ + R+
Sbjct: 3453 KPVGFSVLQLVVTDEDSSHNGPPFFF------TIVTGNDEKAFEVNPQGVLLTSSAIKRK 3506
Query: 561 QQELYFLPVVIEDSSYPVQSSTNTMTIRV 589
+++ Y L V + D+ P SS + IRV
Sbjct: 3507 EKDHYLLQVKVADNGKPQLSSLTYIDIRV 3535
Score = 202 bits (513), Expect = 1e-51
Identities = 167/545 (30%), Positives = 257/545 (47%), Gaps = 53/545 (9%)
Query: 70 SEPQYVGKLHSDLDKG----------EGTVKYTL-----SGDGAGTVFTIDETTGDIHAI 114
SEP Y + D+ G GTV Y+L F ID +G +
Sbjct: 2704 SEPFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLE 2763
Query: 115 RSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSP 174
+SLD E +Y A + + + I+V+D NDN P F PY A + E P
Sbjct: 2764 KSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLP 2823
Query: 175 VGAYVLQVKATDADDPTYGNSARVVYSILQGQPY-----FSIDPKTGVIRTALPNMDREV 229
G+ V+Q++A+DAD G + +V+YS+ Q Q F+I+ +TG I T L +D E
Sbjct: 2824 GGSRVIQIRASDADS---GTNGQVMYSLDQSQSVEVIESFAINMETGWI-TTLKELDHEK 2879
Query: 230 KEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIG 289
++ YQ+ + A D G ++ L+ T IV++T+TDVND+PPRF I+ V E P G I
Sbjct: 2880 RDNYQIKVVASDHGEKI-QLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIA 2938
Query: 290 RIRAVDPDFGQ-NAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKV 348
+ D D + N ++ Y I GD F + T ++ E + +KKPLD E + Y +
Sbjct: 2939 ILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQN--EWKVYVKKPLDREKRDNYLLTI 2996
Query: 349 EASNLHLDHRFHSAGPFKDTATVKISVLDV-DEPPVFSKPLYTMEVYEDTPVGTIIGAVT 407
A++ G F A V++ VLD D PV K LY+ + ED G +I ++
Sbjct: 2997 TATD----------GTFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQIS 3046
Query: 408 AQDLDVGSSA-VRYFIDWKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSN 466
A D D+ S+A + Y + G F ++ + G + T+ LDRE A Y+ + A+
Sbjct: 3047 ATDADIRSNAEITYTL--LGSGAEKFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGGG 3104
Query: 467 PLLTSKVNILINVLDVNEFPPEISV-PYETAVCENAKPGQIIQIVSAADRDLSPAGQQFS 525
+ +I++ + DVN+ PE S PY V EN +PG ++ V A D D AG
Sbjct: 3105 RF--CQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDAD---AGLNRK 3159
Query: 526 FRLSPEAAIKPNFTVRDFRNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQ-SSTNT 584
S + F++ N +GI R Q +Y L + D P + ++T T
Sbjct: 3160 ILYSLIDSADGQFSI----NELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGT 3215
Query: 585 MTIRV 589
+ + V
Sbjct: 3216 VIVSV 3220
Score = 185 bits (469), Expect = 2e-46
Identities = 141/444 (31%), Positives = 217/444 (48%), Gaps = 25/444 (5%)
Query: 80 SDLDKG-EGTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRK 138
+D D G + Y+L D A F+I+E +G I + LDRE + YTL +AVD +
Sbjct: 3150 TDADAGLNRKILYSLI-DSADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPR 3208
Query: 139 PLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARV 198
L I+ V DINDN P F Y ATV E VG VLQV A D +A +
Sbjct: 3209 RLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEA---NAEI 3265
Query: 199 VYSILQGQPY--FSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVN 256
YSI+ G + FSID KTG + + N+D E +Y + ++A D G L+ VN
Sbjct: 3266 TYSIISGNEHGKFSIDSKTGAV-FIIENLDYESSHEYYLTVEATD--GGTPSLSDVATVN 3322
Query: 257 ITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGGNL 316
+ +TD+NDN P F + + + E + + ++ + A D D N+ I Y+I+ G+ G+
Sbjct: 3323 VNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSS 3382
Query: 317 FDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTATVKISVL 376
F I D G +K+ K LD ET YT V+AS+ + + P +T TV I V
Sbjct: 3383 FTI----DPVRGEVKVTKLLDRETISGYTLTVQASD-------NGSPPRVNTTTVNIDVS 3431
Query: 377 DV-DEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRYFIDWKSDGDSYFTID 435
DV D PVFS+ Y++ + E+ PVG + + D D + +F + D
Sbjct: 3432 DVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGNDEKAFEV 3491
Query: 436 GNEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPEISVPYET 495
+G + T+ + R+ Y + + P L+S I I V++ + +PP I +P E
Sbjct: 3492 NPQGVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPAI-LPLEI 3550
Query: 496 AVCENAK--PGQIIQIVSAADRDL 517
+ + + G +I + A D+D+
Sbjct: 3551 FITSSGEEYSGGVIGKIHATDQDV 3574
Score = 165 bits (417), Expect = 2e-40
Identities = 144/520 (27%), Positives = 243/520 (46%), Gaps = 36/520 (6%)
Query: 78 LHSDLDKGEGT-VKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIET 136
+H + EG V Y+++ + FTI+ TG I+ I LD E P Y L +A D T
Sbjct: 2202 VHVQANSPEGLKVFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLT 2261
Query: 137 RKPLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDAD-DPTYGNS 195
E + I V DINDN P F Y T+ E S +G V+QV+ATD+D +P G S
Sbjct: 2262 GAHAEVFVDII--VDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGIS 2319
Query: 196 ARVVYSILQGQPYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIV 255
++ + + +F +D TG+I + L +D E Q+ + ++A D G + L+ IV
Sbjct: 2320 YQMFGNHSKSHDHFHVDSSTGLI-SLLRTLDYEQSRQHTIFVRAVD--GGMPTLSSDVIV 2376
Query: 256 NITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGGN 315
+ +TD+NDNPP F + I+ ++ E +P G + ++A D D +++Y+I+ G+
Sbjct: 2377 TVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHK 2436
Query: 316 LFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTATVKISV 375
F I D+ G+I L K Y+ + S+ G F+ + V ++V
Sbjct: 2437 HFVI----DSATGIITLSNLHRHALKPFYSLNLSVSD----------GVFRSSTQVHVTV 2482
Query: 376 LDVD-EPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVG-SSAVRYFIDWKSDGDSYFT 433
+ + P F + Y +E+ E+ P+ T++ V D D G V Y I D ++
Sbjct: 2483 IGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYI 2542
Query: 434 IDGNEGTIATNELLDRESTAQYNFSI--IASKVSNPLLTSKVNILINVLDVNEFPPEI-S 490
G I T E LDRE+ A+ S+ +A + VN+++ D N+ P+ +
Sbjct: 2543 --NERGQIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILT--DDNDNAPQFRA 2598
Query: 491 VPYETAVCENAKPGQIIQIVSAADRDL-SPAGQQFSFRLSPEAAIKPNFTVRDFRNNTAG 549
YE + +A G + V A+D D S A ++ E ++K N + N +G
Sbjct: 2599 TKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSE-SVKENLEI----NKLSG 2653
Query: 550 IETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRV 589
+ T + + E + V D+ P + S + +++
Sbjct: 2654 VITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKI 2693
Score = 162 bits (411), Expect = 9e-40
Identities = 135/444 (30%), Positives = 214/444 (48%), Gaps = 30/444 (6%)
Query: 95 GDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFII-KVQDI 153
G+ T I+ T H + +L EE + A+ + + + E E I +
Sbjct: 650 GENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSV 709
Query: 154 NDNEPKFLDG-PYVATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQG--QPYFS 210
N + P+F P V E PVG+ V+ + +TD D G + ++VY++ G F
Sbjct: 710 NAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDT---GFNGKLVYAVSGGNEDSCFM 766
Query: 211 IDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFP 270
ID +TG+++ P +DRE ++Y + I D+G + A ++++ + D NDNPP F
Sbjct: 767 IDMETGMLKILSP-LDRETTDKYTLNITVYDLG--IPQKAAWRLLHVVVVDANDNPPEFL 823
Query: 271 KSIFHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGGNLFDIVTDEDTQEGVI 330
+ + ++V E + S I ++ A D D G N + Y+IV D VT GV+
Sbjct: 824 QESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTFSIDSVT------GVV 877
Query: 331 KLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTATVKISVLDV-DEPPVFSKPLY 389
+ +PLD E + ++ K+EA + + T VK+S+ DV D PP F P Y
Sbjct: 878 NIARPLDRELQHEHSLKIEARD-----QAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNY 932
Query: 390 TMEVYEDTPVGTIIGAVTAQDLDVGSSA-VRYFIDWKSDGDSYFTIDGNEGTIATNELLD 448
++V ED P GT+I + A D D+G S VRY + G+ F +D G + + LD
Sbjct: 933 RVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSL--LDHGEGNFDVDKLSGAVRIVQQLD 990
Query: 449 RESTAQYNFSIIASKVSNPL-LTSKVNILINVLDVNE--FPPEISVPYET-AVCENAKPG 504
E YN ++ A P+ L+S + + V+DVNE PP S E V E+A G
Sbjct: 991 FEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVG 1050
Query: 505 QIIQIVSAADRDLSPAGQ-QFSFR 527
++ VSA D D G+ ++S R
Sbjct: 1051 SLVMTVSAHDEDARRDGEIRYSIR 1074
Score = 161 bits (407), Expect = 3e-39
Identities = 131/455 (28%), Positives = 212/455 (46%), Gaps = 46/455 (10%)
Query: 79 HSDLDKGEGTVKYTLSGDGAGT-VFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETR 137
H + + +G ++Y++ DG+G VF I E TG I LDRE Y L A D +
Sbjct: 1059 HDEDARRDGEIRYSIR-DGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATD-QGV 1116
Query: 138 KPLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSAR 197
PL E I+V+D+NDN P+ + Y + E SP V+Q++A D D ++ +
Sbjct: 1117 VPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDS---SSNDK 1173
Query: 198 VVYSILQGQP--YFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIV 255
++Y I G P +FSI PKTG+I T +DRE ++++ + + D G IV
Sbjct: 1174 LMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIV 1233
Query: 256 NITLTDVNDNPPRFPKSIFHLKVP-------ESSPIGSAIGRIRAVDPDFGQNAEIEYNI 308
I D NDN P+F + + +++P E + + + A D D G NAEI Y+I
Sbjct: 1234 KI--LDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSI 1291
Query: 309 VPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDT 368
G+ F I + + GV+ K+ F Y L + G + +
Sbjct: 1292 EDGNEHGKFFI----EPKTGVVSSKR---FSAAGEYDI--------LSIKAVDNGRPQKS 1336
Query: 369 ATVKISVLDVD------EPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRYFI 422
+T ++ + + EP F + +T V E PV +IG ++ + + +F
Sbjct: 1337 STTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGI----PLWFD 1392
Query: 423 DWKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVLDV 482
+ DS+F +D GTI + LD E + YN ++ A+ + +LT + I V+D
Sbjct: 1393 ITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTILT---QVFIKVIDT 1449
Query: 483 NEFPPEISV-PYETAVCENAKPGQIIQIVSAADRD 516
N+ P+ S YE + E+ P I +SA D+D
Sbjct: 1450 NDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQD 1484
Score = 156 bits (394), Expect = 8e-38
Identities = 123/440 (27%), Positives = 211/440 (47%), Gaps = 44/440 (10%)
Query: 91 YTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKV 150
+ ++G + F +D+ TG I + LD E+K Y L +A D T ++ IKV
Sbjct: 1391 FDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTIL----TQVFIKV 1446
Query: 151 QDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQP--- 207
D ND+ P+F Y +PE + +LQ+ A D D+ +++Y++ +
Sbjct: 1447 IDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKN-----KLIYTLQSSRDPLS 1501
Query: 208 --YFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDN 265
F +DP TG + T+ +D E Q+ + + +D + +VN++ D ND+
Sbjct: 1502 LKKFRLDPATGSLYTS-EKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVS--DTNDH 1558
Query: 266 PPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGGNLFDIVTDEDT 325
P F S + +V ES+ +GS + ++ A+D D G+NAE+ Y+I G+ GN F I D
Sbjct: 1559 APWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMI----DP 1614
Query: 326 QEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTATVKISVLDVDE-PPVF 384
G IK K LD + Y V+A++ + P + +V+I V D P F
Sbjct: 1615 VLGSIKTAKELDRSNQAEYDLMVKATD-------KGSPPMSEITSVRIFVTIADNASPKF 1667
Query: 385 SKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRYFIDWKSDGDSYFTIDGNEGTIATN 444
+ Y++E+ E +G+ +G VTA S+V Y I + GD+ F I+ + GTI T
Sbjct: 1668 TSKEYSVELSETVSIGSFVGMVTAH----SQSSVVYEIKDGNTGDA-FDINPHSGTIITQ 1722
Query: 445 ELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPE-ISVPYETAVCENAKP 503
+ LD E+ Y I + ++ L++ +L+++ D N+ P + Y + E+A
Sbjct: 1723 KALDFETLPIYTLIIQGTNMAG--LSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASI 1780
Query: 504 GQII-------QIVSAADRD 516
++ ++ AAD D
Sbjct: 1781 NSVVLTDRNVPLVIRAADAD 1800
Score = 155 bits (393), Expect = 1e-37
Identities = 148/520 (28%), Positives = 238/520 (45%), Gaps = 50/520 (9%)
Query: 80 SDLDKGEGTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDREE-KPFYTLRAQAVDIETRK 138
SD+DK ++Y++ F ID TG I + +L R KPFY+L D R
Sbjct: 2420 SDIDK----LQYSILSGNDHKHFVIDSATGII-TLSNLHRHALKPFYSLNLSVSDGVFRS 2474
Query: 139 PLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARV 198
++ + V N + P FL Y + E +P+ V++VK TD D YG+ V
Sbjct: 2475 ----STQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGH---V 2527
Query: 199 VYSILQ--GQPYFSIDPKTGVIRTALPNMDREVKEQ--YQVLIQAKDMGGQLGGLAGTTI 254
Y I+ + F I+ + + L +DRE + V + AKD GG++
Sbjct: 2528 TYHIVNDFAKDRFYINERGQIF--TLEKLDRETPAEKVISVRLMAKDAGGKVAFCT---- 2581
Query: 255 VNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGG 314
VN+ LTD NDN P+F + + + + S+ G+++ ++ A D D G NA+I Y I D
Sbjct: 2582 VNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAI-EADSE 2640
Query: 315 NLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTAT-VKI 373
++ + + + + GVI K+ L + +TF V A + + P K++ V +
Sbjct: 2641 SVKENL-EINKLSGVITTKESLIGLENEFFTFFVRAVD--------NGSPSKESVVLVYV 2691
Query: 374 SVLDVD-EPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRYFI----DWKSDG 428
+L + + P FS+P YT V ED P+GT I + A+ S V Y + +S+
Sbjct: 2692 KILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEH----SGTVLYSLVKGNTPESNR 2747
Query: 429 DSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNP-LLTSKVNILINVLDVNEFPP 487
D F ID G + + LD E+T Y FSI+A + + + V++ I V D N+ P
Sbjct: 2748 DESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSP 2807
Query: 488 EI-SVPYETAVCENAKPGQIIQIVSAADRDLSPAGQ-QFSFRLSPEAAIKPNFTVRDFRN 545
S PYE + EN G + + A+D D GQ +S S + +F + N
Sbjct: 2808 VFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAI----N 2863
Query: 546 NTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTM 585
G T +++ Y + VV D +Q S+ +
Sbjct: 2864 METGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAI 2903
Score = 131 bits (330), Expect = 2e-30
Identities = 120/515 (23%), Positives = 221/515 (42%), Gaps = 49/515 (9%)
Query: 86 EGTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESE 145
+ +V Y + G F I+ +G I ++LD E P YTL Q ++ L +
Sbjct: 1694 QSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAG---LSTNTT 1750
Query: 146 FIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQ-------VKATDADDPTYGNSARV 198
++ +QD NDN P F+ Y + E + + + VL ++A DAD + +A +
Sbjct: 1751 VLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDS---NALL 1807
Query: 199 VYSILQGQ--PYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVN 256
VY I++ YF+ID TG I T L ++D E + +Q DMG V
Sbjct: 1808 VYHIVEPSVHTYFAIDSSTGAIHTVL-SLDYEETSIFHFTVQVHDMGTPRLFAEYAANVT 1866
Query: 257 ITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGGNL 316
+ + D+ND PP F K ++ + + G + + A D D +++ Y+I G+ G
Sbjct: 1867 VHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEK 1926
Query: 317 FDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTATVKISVL 376
F + D + G + ++ ++ Y V AS+ G F +VKI+V
Sbjct: 1927 FSM----DYKTGALTVQNTTQLRSR--YELTVRASD----------GRFAGLTSVKINVK 1970
Query: 377 DVDEPPV-FSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRYFIDWKSDGDSYFTID 435
+ E + F++ +Y+ V E++ + +TA + + + + D F I
Sbjct: 1971 ESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPINEPLFYHIL----NPDRRFKIS 2026
Query: 436 GNEGTIATNEL-LDRESTAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPE-ISVPY 493
G ++T DRE ++ + ++ P + V + + V D N+ P +++PY
Sbjct: 2027 RTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPY 2086
Query: 494 ETAVCENAKPGQIIQIVSAADRDLSPAGQ--------QFSFRLSP--EAAIKPNFTVRDF 543
V + + G +I+ V+A DRD G+ F++ P E ++K F +
Sbjct: 2087 YAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEHFQIGPLGEISLKKQFELDTL 2146
Query: 544 RNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYPV 578
++G + +P+ + + + PV
Sbjct: 2147 NKEYLVTVVAKDGGNPAFSAEVIVPITVMNKAMPV 2181
Score = 96.3 bits (238), Expect = 1e-19
Identities = 107/393 (27%), Positives = 172/393 (43%), Gaps = 48/393 (12%)
Query: 71 EPQYVGKLHSDLDKGEGTVKYTLS---GDGAGTVFTIDETTGD----IHAIRSLDREEKP 123
+P Y D D+G +LS GD T+ G + AI +D + P
Sbjct: 270 DPAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHP 329
Query: 124 F-YTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGP-------YVATVPEMSPV 175
F Y L QA D T P +KV I+ P+F GP Y A + E +P
Sbjct: 330 FGYNLTLQAKDKGT-----PPQFSSVKV--IHVTSPQFKAGPVKFEKDVYRAEISEFAPP 382
Query: 176 GAYVLQVKATDADDPTYGNSARVVYSILQGQPYFSIDPKTGVIRTALPNMDREVKEQYQV 235
V+ VKA P Y + R V+ G+ FS++ TG+I P + R+ +++
Sbjct: 383 NTPVVMVKAI----PAYSH-LRYVFKSTPGKAKFSLNYNTGLISILEP-VKRQQAAHFEL 436
Query: 236 LIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVD 295
+ D +T V + + N NPP F ++ + E+ PIG+ + + AVD
Sbjct: 437 EVTTSDR-------KASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVD 489
Query: 296 PDFGQNAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFE-TKKAYTFKVEASNLH 354
PD G+N + Y+I NL + D G + + LD+E + YT ++ AS+
Sbjct: 490 PDEGENGYVTYSI-----ANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWG 544
Query: 355 LDHRFHSAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVG 414
L +R + AT+ ++ L+ D P+F K + D VG I V+A D D
Sbjct: 545 LPYR----REVEVLATITLNNLN-DNTPLFEKINCEGTIPRDLGVGEQITTVSAIDAD-E 598
Query: 415 SSAVRYFIDWKSDGDSYFTIDGNEGTIATNELL 447
V+Y I+ ++ D +F+++ N G ++ L
Sbjct: 599 LQLVQYQIEAGNELD-FFSLNPNSGVLSLKRSL 630
Score = 94.4 bits (233), Expect = 4e-19
Identities = 106/410 (25%), Positives = 170/410 (41%), Gaps = 36/410 (8%)
Query: 117 LDREEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVG 176
L+RE K YTL +A++ T +E ++ ++V D ND P F Y ++PE + +
Sbjct: 108 LNREVKDHYTLIVKALEKNTN--VEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIR 165
Query: 177 AYVLQVKATDADDPTYGNSARVVYSILQGQPYFSIDPKTGVIRTALPNMDREVKEQYQVL 236
+ +V ATDAD G + YS F+I P +GVI +D + Y++
Sbjct: 166 TSIARVSATDAD---IGTNGEFYYSFKDRTDMFAIHPTSGVI-VLTGRLDYLETKLYEME 221
Query: 237 IQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDP 296
I A D G +L G +G + + + P P A + D
Sbjct: 222 ILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRDPAYAIVTVDDC 281
Query: 297 DFGQNAEI-EYNIVPGDGGNLFDIVTD-EDTQEGVIKLKKPLDFETKK-AYTFKVEASNL 353
D G N +I +IV GD F V ++E +K +D+++ Y ++A +
Sbjct: 282 DQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDK 341
Query: 354 HLDHRFHSAGPFKDTATVKISVLDVDEP-----PV-FSKPLYTMEVYEDTPVGTIIGAVT 407
+F S + V+ V P PV F K +Y E+ E P T + V
Sbjct: 342 GTPPQFSS-----------VKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVK 390
Query: 408 AQDLDVGSSAVRYFIDWKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNP 467
A S +RY + G + F+++ N G I+ E + R+ A + + S
Sbjct: 391 AIP---AYSHLRYVFK-STPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSD---- 442
Query: 468 LLTSKVNILINVLDVNEFPPEIS-VPYETAVCENAKPGQIIQIVSAADRD 516
+ +L+ VL N PPE + Y+ A EN G + +SA D D
Sbjct: 443 -RKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPD 491
Score = 94.4 bits (233), Expect = 4e-19
Identities = 111/438 (25%), Positives = 180/438 (41%), Gaps = 48/438 (10%)
Query: 91 YTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKV 150
Y+++ G F++D TG + + + T+RA ++ I V
Sbjct: 1916 YSITEGNIGEKFSMDYKTGALTVQNTTQLRSRYELTVRASDGRFAGLTSVK------INV 1969
Query: 151 QDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKA--TDADDPTYGNSARVVYSILQGQPY 208
++ ++ KF Y A V E S + + A ++P + Y IL
Sbjct: 1970 KESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPINEPLF-------YHILNPDRR 2022
Query: 209 FSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPR 268
F I +GV+ T DRE +E + V+++ + +V + + D NDN P
Sbjct: 2023 FKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEE--HKPSAVAHVVVKVIVEDQNDNAPV 2080
Query: 269 FPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGGNLFDIVTDEDTQEG 328
F ++ V + +G I + AVD D G+N E+ Y + + F I G
Sbjct: 2081 FVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYL--KEHHEHFQI-----GPLG 2133
Query: 329 VIKLKKPLDFET-KKAYTFKVEASNLHLDHRFHSAGP-FKDTATVKISVLDVDEPPVFSK 386
I LKK + +T K Y V A + P F V I+V++ PVF K
Sbjct: 2134 EISLKKQFELDTLNKEYLVTVVAKD--------GGNPAFSAEVIVPITVMN-KAMPVFEK 2184
Query: 387 PLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRYFIDWKSDGD--SYFTIDGNEGTIATN 444
P Y+ E+ E V + + V A + V Y I +DGD S FTI+ N G I
Sbjct: 2185 PFYSAEIAESIQVHSPVVHVQANSPE--GLKVFYSI---TDGDPFSQFTINFNTGVINVI 2239
Query: 445 ELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVL--DVNEFPPEIS-VPYETAVCENA 501
LD E+ Y SI + ++ L + + ++++ D+N+ PP + Y + E +
Sbjct: 2240 APLDFEAHPAYKLSI---RATDSLTGAHAEVFVDIIVDDINDNPPVFAQQSYAVTLSEAS 2296
Query: 502 KPGQIIQIVSAADRDLSP 519
G + V A D D P
Sbjct: 2297 VIGTSVVQVRATDSDSEP 2314
Score = 56.6 bits (135), Expect = 9e-08
Identities = 65/247 (26%), Positives = 105/247 (42%), Gaps = 33/247 (13%)
Query: 262 VNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNA-EIEYNIVPGDGGNLFD-- 318
+ P +F +++ V E+S + +G + A E+ Y IV GD NLF
Sbjct: 27 LEQTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAE 86
Query: 319 --IVTD-----EDTQEGVIKLKKPLDFETKKAYTFKVEA--SNLHLDHRFHSAGPFKDTA 369
I+ D T+ G + L+ E K YT V+A N +++ R
Sbjct: 87 EYILGDFCFLRIRTKGGNTAI---LNREVKDHYTLIVKALEKNTNVEAR----------T 133
Query: 370 TVKISVLDV-DEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRYFIDWKSDG 428
V++ VLD D P+FS Y++ + E+T + T I V+A D D+G++ Y+ D
Sbjct: 134 KVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYS--FKDR 191
Query: 429 DSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPL-----LTSKVNILINVLDVN 483
F I G I LD T Y I+A+ L ++S + +++ N
Sbjct: 192 TDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQAN 251
Query: 484 EFPPEIS 490
E P I+
Sbjct: 252 ECAPVIT 258
>gi|13435366 desmocollin 2 isoform Dsc2b preproprotein [Homo
sapiens]
Length = 847
Score = 214 bits (545), Expect = 3e-55
Identities = 188/636 (29%), Positives = 297/636 (46%), Gaps = 35/636 (5%)
Query: 50 QRVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAG----TVFTID 105
+R KR W +LE +G P ++ ++ SD + T+ Y++ G G +F ++
Sbjct: 131 RRAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQNY-TIYYSIRGPGVDQEPRNLFYVE 189
Query: 106 ETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPY 165
TG+++ R +DRE+ + + A A + P P IIK++D NDN P F + Y
Sbjct: 190 RDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELP-LPLIIKIEDENDNYPIFTEETY 248
Query: 166 VATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQP----YFSIDPKTGVIRTA 221
T+ E VG V QV ATD D+P ++ R+ YSI+ P FS+ P TGVI T
Sbjct: 249 TFTIFENCRVGTTVGQVCATDKDEPDTMHT-RLKYSIIGQVPPSPTLFSMHPTTGVITTT 307
Query: 222 LPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPES 281
+DRE+ ++YQ+ I+ +DM GQ GL T+ I + DVND+ P F ++ + V E+
Sbjct: 308 SSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSYVTSVEEN 367
Query: 282 SPIGSAIGRIRAVDPDFGQNAE--IEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFE 339
+ + I R+ D D A Y I+ G+ F IVTD T EGV+ + KPL++E
Sbjct: 368 T-VDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLNYE 426
Query: 340 TKKAYTFKVEASNLHLDHRFHSAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTPV 399
K+ ++ N R S TATV ++V D DE P + P+ T+ + E+ V
Sbjct: 427 EKQQMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEV 486
Query: 400 GTIIGAVTAQDLDV-GSSAVRYFIDWKSDGDSYFTIDGNEGTIATNELLDRES----TAQ 454
GT A D + SS +RY +D + TID N G+I LDRE+
Sbjct: 487 GTTSNGYKAYDPETRSSSGIRY--KKLTDPTGWVTIDENTGSIKVFRSLDREAETIKNGI 544
Query: 455 YNFSIIASKVSNPLLTSKVNILINVLDVNEFPPEISVPYETAVCENAKPGQIIQIVSAAD 514
YN +++AS T + I++ DVN+ P +P +T + KP + A D
Sbjct: 545 YNITVLASDQGGRTCTGTLGIILQ--DVNDNSP--FIPKKTVII--CKPTMSSAEIVAVD 598
Query: 515 RDLSPAGQQFSFRLSPEAAIKPNFTVRDFRNNTAGIETRRNGYSRRQQELYFLPVVIEDS 574
D G F F L + N+TA + +N Y +P+ + D
Sbjct: 599 PDEPIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQNDPPFGS---YVVPITVRDR 655
Query: 575 SYPVQSSTNTMTIRVCRCDSDGTILSCNVEAIFLPVGLSTG--ALIAILLCIVILLAIVV 632
SS ++ + +C C ++ + V+ G+ G A++AILL I +L I+
Sbjct: 656 L--GMSSVTSLDVTLCDCITEND-CTHRVDPRIGGGGVQLGKWAILAILLGIALLFCILF 712
Query: 633 LYVALRRQKKKDTLMTSKEDIRDNVIHYDDEGGGEE 668
V K + + + N+I + E G++
Sbjct: 713 TLVCGASGTSKQPKVIPDDLAQQNLIVSNTEAPGDD 748
>gi|13435364 desmocollin 2 isoform Dsc2a preproprotein [Homo
sapiens]
Length = 901
Score = 214 bits (545), Expect = 3e-55
Identities = 188/636 (29%), Positives = 297/636 (46%), Gaps = 35/636 (5%)
Query: 50 QRVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAG----TVFTID 105
+R KR W +LE +G P ++ ++ SD + T+ Y++ G G +F ++
Sbjct: 131 RRAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQNY-TIYYSIRGPGVDQEPRNLFYVE 189
Query: 106 ETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPY 165
TG+++ R +DRE+ + + A A + P P IIK++D NDN P F + Y
Sbjct: 190 RDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELP-LPLIIKIEDENDNYPIFTEETY 248
Query: 166 VATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQP----YFSIDPKTGVIRTA 221
T+ E VG V QV ATD D+P ++ R+ YSI+ P FS+ P TGVI T
Sbjct: 249 TFTIFENCRVGTTVGQVCATDKDEPDTMHT-RLKYSIIGQVPPSPTLFSMHPTTGVITTT 307
Query: 222 LPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPES 281
+DRE+ ++YQ+ I+ +DM GQ GL T+ I + DVND+ P F ++ + V E+
Sbjct: 308 SSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSYVTSVEEN 367
Query: 282 SPIGSAIGRIRAVDPDFGQNAE--IEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFE 339
+ + I R+ D D A Y I+ G+ F IVTD T EGV+ + KPL++E
Sbjct: 368 T-VDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLNYE 426
Query: 340 TKKAYTFKVEASNLHLDHRFHSAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTPV 399
K+ ++ N R S TATV ++V D DE P + P+ T+ + E+ V
Sbjct: 427 EKQQMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEV 486
Query: 400 GTIIGAVTAQDLDV-GSSAVRYFIDWKSDGDSYFTIDGNEGTIATNELLDRES----TAQ 454
GT A D + SS +RY +D + TID N G+I LDRE+
Sbjct: 487 GTTSNGYKAYDPETRSSSGIRY--KKLTDPTGWVTIDENTGSIKVFRSLDREAETIKNGI 544
Query: 455 YNFSIIASKVSNPLLTSKVNILINVLDVNEFPPEISVPYETAVCENAKPGQIIQIVSAAD 514
YN +++AS T + I++ DVN+ P +P +T + KP + A D
Sbjct: 545 YNITVLASDQGGRTCTGTLGIILQ--DVNDNSP--FIPKKTVII--CKPTMSSAEIVAVD 598
Query: 515 RDLSPAGQQFSFRLSPEAAIKPNFTVRDFRNNTAGIETRRNGYSRRQQELYFLPVVIEDS 574
D G F F L + N+TA + +N Y +P+ + D
Sbjct: 599 PDEPIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQNDPPFGS---YVVPITVRDR 655
Query: 575 SYPVQSSTNTMTIRVCRCDSDGTILSCNVEAIFLPVGLSTG--ALIAILLCIVILLAIVV 632
SS ++ + +C C ++ + V+ G+ G A++AILL I +L I+
Sbjct: 656 L--GMSSVTSLDVTLCDCITEND-CTHRVDPRIGGGGVQLGKWAILAILLGIALLFCILF 712
Query: 633 LYVALRRQKKKDTLMTSKEDIRDNVIHYDDEGGGEE 668
V K + + + N+I + E G++
Sbjct: 713 TLVCGASGTSKQPKVIPDDLAQQNLIVSNTEAPGDD 748
Score = 31.2 bits (69), Expect = 3.9
Identities = 16/47 (34%), Positives = 26/47 (55%), Gaps = 2/47 (4%)
Query: 734 DSLATYAYEGSGSVAESLSSIDSLTTEADQDYDYLTDWGPRFKVLAD 780
D + TY YEG GSVA S+ + + ++L + P+F+ LA+
Sbjct: 852 DYVLTYNYEGRGSVAGSVGCCSE--RQEEDGLEFLDNLEPKFRTLAE 896
>gi|148539848 desmocollin 3 isoform Dsc3b preproprotein [Homo
sapiens]
Length = 839
Score = 211 bits (538), Expect = 2e-54
Identities = 189/632 (29%), Positives = 299/632 (47%), Gaps = 44/632 (6%)
Query: 24 QPQPQQTLATEPRENVIHLPGQRSH-FQRVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDL 82
Q Q + T+ E ++ V R +R KR W + E +G P ++ ++ SD
Sbjct: 104 QTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDA 163
Query: 83 DKGEGTVKYTLSGDGAG----TVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRK 138
+ TV Y++SG G +F I+ TG++ R +DREE + L A A +
Sbjct: 164 AQNY-TVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYS 222
Query: 139 PLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARV 198
P I+V+D NDN P F + Y V E S G V V ATD D+P ++ R+
Sbjct: 223 ADLP-LPLPIRVEDENDNHPVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHT-RL 280
Query: 199 VYSILQGQP----YFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTI 254
YSILQ P FS+ P TGVI T +DREV ++Y ++++ +DM GQ GL GT+
Sbjct: 281 KYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTST 340
Query: 255 VNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDF--GQNAEIEYNIVPGD 312
IT+TD NDN P F ++ + V E++ I RI D D N + + I+ G+
Sbjct: 341 CIITVTDSNDNAPTFRQNAYEAFVEENA-FNVEILRIPIEDKDLINTANWRVNFTILKGN 399
Query: 313 GGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTATVK 372
F I TD++T EGV+ + KPL++E + ++ +N R + A V
Sbjct: 400 ENGHFKISTDKETNEGVLSVVKPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVT 459
Query: 373 ISVLDVDEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLD-VGSSAVRYFIDWKSDGDSY 431
+ V D+DE P + + + E+ VG+ I A D + + +RY D +
Sbjct: 460 VHVRDLDEGPECTPAAQYVRIKENLAVGSKINGYKAYDPENRNGNGLRY--KKLHDPKGW 517
Query: 432 FTIDGNEGTIATNELLDRE----STAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPP 487
TID G+I T+++LDRE YN +++A + T + +N+ DVN+ PP
Sbjct: 518 ITIDEISGSIITSKILDREVETPKNELYNITVLAIDKDDRSCTG--TLAVNIEDVNDNPP 575
Query: 488 EISVPYETAVCENAKPGQIIQIVSAADRDLSPAGQQFSFRL---SPEAAIKPNFTVRDFR 544
EI Y +C KP + A D D G F F L SPE I +++
Sbjct: 576 EILQEY-VVIC---KPKMGYTDILAVDPDEPVHGAPFYFSLPNTSPE--ISRLWSLTKVN 629
Query: 545 NNTAGIETRRN-GYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRVCRCDSDGTILSCNV 603
+ A + ++N G+ Y +P+ ++D + Q++T + + +C C C
Sbjct: 630 DTAARLSYQKNAGFQE-----YTIPITVKDRA--GQAATKLLRVNLCECTHP---TQCRA 679
Query: 604 EAIFLPVGLSTGALIAILLCIVILLAIVVLYV 635
+ V L A++AILL I +L ++++ V
Sbjct: 680 TSRSTGVILGKWAILAILLGIALLFSVLLTLV 711
>gi|148539846 desmocollin 3 isoform Dsc3a preproprotein [Homo
sapiens]
Length = 896
Score = 211 bits (538), Expect = 2e-54
Identities = 189/632 (29%), Positives = 299/632 (47%), Gaps = 44/632 (6%)
Query: 24 QPQPQQTLATEPRENVIHLPGQRSH-FQRVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDL 82
Q Q + T+ E ++ V R +R KR W + E +G P ++ ++ SD
Sbjct: 104 QTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDA 163
Query: 83 DKGEGTVKYTLSGDGAG----TVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRK 138
+ TV Y++SG G +F I+ TG++ R +DREE + L A A +
Sbjct: 164 AQNY-TVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYS 222
Query: 139 PLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARV 198
P I+V+D NDN P F + Y V E S G V V ATD D+P ++ R+
Sbjct: 223 ADLP-LPLPIRVEDENDNHPVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHT-RL 280
Query: 199 VYSILQGQP----YFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTI 254
YSILQ P FS+ P TGVI T +DREV ++Y ++++ +DM GQ GL GT+
Sbjct: 281 KYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTST 340
Query: 255 VNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDF--GQNAEIEYNIVPGD 312
IT+TD NDN P F ++ + V E++ I RI D D N + + I+ G+
Sbjct: 341 CIITVTDSNDNAPTFRQNAYEAFVEENA-FNVEILRIPIEDKDLINTANWRVNFTILKGN 399
Query: 313 GGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTATVK 372
F I TD++T EGV+ + KPL++E + ++ +N R + A V
Sbjct: 400 ENGHFKISTDKETNEGVLSVVKPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVT 459
Query: 373 ISVLDVDEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLD-VGSSAVRYFIDWKSDGDSY 431
+ V D+DE P + + + E+ VG+ I A D + + +RY D +
Sbjct: 460 VHVRDLDEGPECTPAAQYVRIKENLAVGSKINGYKAYDPENRNGNGLRY--KKLHDPKGW 517
Query: 432 FTIDGNEGTIATNELLDRE----STAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPP 487
TID G+I T+++LDRE YN +++A + T + +N+ DVN+ PP
Sbjct: 518 ITIDEISGSIITSKILDREVETPKNELYNITVLAIDKDDRSCTG--TLAVNIEDVNDNPP 575
Query: 488 EISVPYETAVCENAKPGQIIQIVSAADRDLSPAGQQFSFRL---SPEAAIKPNFTVRDFR 544
EI Y +C KP + A D D G F F L SPE I +++
Sbjct: 576 EILQEY-VVIC---KPKMGYTDILAVDPDEPVHGAPFYFSLPNTSPE--ISRLWSLTKVN 629
Query: 545 NNTAGIETRRN-GYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRVCRCDSDGTILSCNV 603
+ A + ++N G+ Y +P+ ++D + Q++T + + +C C C
Sbjct: 630 DTAARLSYQKNAGFQE-----YTIPITVKDRA--GQAATKLLRVNLCECTHP---TQCRA 679
Query: 604 EAIFLPVGLSTGALIAILLCIVILLAIVVLYV 635
+ V L A++AILL I +L ++++ V
Sbjct: 680 TSRSTGVILGKWAILAILLGIALLFSVLLTLV 711
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 211 bits (536), Expect = 3e-54
Identities = 154/506 (30%), Positives = 248/506 (49%), Gaps = 26/506 (5%)
Query: 87 GTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEF 146
G +KY++S +F I+ +TG + ++LD E + + A+D
Sbjct: 3122 GLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISAID-GGWVARTGYCSV 3180
Query: 147 IIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQ 206
+ V D+NDN P FL Y TV E +P G V+ + ATDAD G +A + Y++
Sbjct: 3181 TVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADS---GTNAVIAYTVQSSD 3237
Query: 207 P-YFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDN 265
F IDP TGVI T +D E K+ Y + ++A ++ + T VNI L N+
Sbjct: 3238 SDLFVIDPNTGVITTQ-GFLDFETKQSYHLTVKAFNVPDEERCSFAT--VNIQLKGTNEY 3294
Query: 266 PPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGGNLFDIVTDEDT 325
PRF +++ ++ E++P G+ +G + A D D G + E+ Y I F I +
Sbjct: 3295 VPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQI----NK 3350
Query: 326 QEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTATVKISVLDVDEPPVFS 385
+ G I + LD E ++ + KV A N G D TV ++VLD ++PP+F+
Sbjct: 3351 KTGQIYVSGILDREKEERVSLKVLAKNFG-----SIRGADIDEVTVNVTVLDANDPPIFT 3405
Query: 386 KPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVR--YFIDWKSDGDSYFTIDGNEGTIAT 443
+Y++++ E P+GT + V+A D D S R YFI ++ + F+I+ G I
Sbjct: 3406 LNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGA-FSINPQTGQITV 3464
Query: 444 NELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPEISVPYETAVCENAKP 503
LDRE+ YN S++A P T ++L+ + D+N+ P ++V E V EN +P
Sbjct: 3465 TAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDINDNGPMLTVS-EGEVMENKRP 3523
Query: 504 GQIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNFTVRDFRNNTAGIETRRNGYSRRQQE 563
G ++ + + D DL P F++ L F++ +TAG+ + R Q
Sbjct: 3524 GTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSL-----STAGVLSTTREIDREQIA 3578
Query: 564 LYFLPVVIEDSSYPVQSSTNTMTIRV 589
++L VV +DS P SST T+ I V
Sbjct: 3579 DFYLSVVTKDSGVPQMSSTGTVHITV 3604
Score = 191 bits (485), Expect = 2e-48
Identities = 166/557 (29%), Positives = 259/557 (46%), Gaps = 37/557 (6%)
Query: 64 LEEYVGSEPQYVGKLHSDLDKGEGT-VKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEK 122
+EE +G + + D D+G V YT+ GA F ID +GD+ A R LDRE +
Sbjct: 1749 VEENIGDGSKIMQLTAMDADEGANALVTYTIIS-GADDSFRIDPESGDLIATRRLDRERR 1807
Query: 123 PFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQV 182
Y+L +A D + I V D+ND+ PKF Y +PE + G+ V +
Sbjct: 1808 SKYSLLVRADD----GLQSSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAI 1863
Query: 183 KATDADDPTYGNSARVVYSILQGQPYFSIDPKTGVIR-TALPNMDREVKEQYQVLIQAKD 241
ATD D G +V + +F ++P TGV T L +D EV++ Y + ++A+D
Sbjct: 1864 LATDDDSGVNGEITYIVNEDDEDGIFF-LNPITGVFNLTRL--LDYEVQQYYILTVRAED 1920
Query: 242 MGGQLGGLAGTTI-VNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQ 300
GGQ TTI V + DVNDNPP F + + + E+ P+GS + D D G
Sbjct: 1921 GGGQF-----TTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGI 1975
Query: 301 NAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFH 360
N+++ Y+I GD F + + GV+K+ K LD E++ Y V+ +L
Sbjct: 1976 NSQLTYSIASGDSLGQFTV-----DKNGVLKVLKALDRESQSFYNLVVQVHDLPQ----I 2026
Query: 361 SAGPFKDTATVKISVLDV-DEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVR 419
A F TA V I +LDV D PP F P T + E+TP+ T++ A D D G ++
Sbjct: 2027 PASRFTSTAQVSIILLDVNDNPPTFLSPKLTY-IPENTPIDTVVFKAQATDPDSGPNSYI 2085
Query: 420 YFIDWKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINV 479
+ G+ F+I +G + LDRE + Y +++A+ P L+S +++ V
Sbjct: 2086 EYTLLNPLGNK-FSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMV 2144
Query: 480 LDVNEFPPEIS-VPYETAVCENAKPGQIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNF 538
LD+N+ P + Y+ + EN G I V AAD D GQ I
Sbjct: 2145 LDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQ-------VRYGIVNGN 2197
Query: 539 TVRDFR-NNTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRVCRCDSDGT 597
T ++FR ++ G T R + Y L V D ++ T+T++I + +
Sbjct: 2198 TNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVP 2257
Query: 598 ILSCNVEAIFLPVGLST 614
+ + ++ +P L T
Sbjct: 2258 VFELSPYSVNVPENLGT 2274
Score = 177 bits (448), Expect = 4e-44
Identities = 159/522 (30%), Positives = 256/522 (49%), Gaps = 51/522 (9%)
Query: 80 SDLDKG-EGTVKYTL-SGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETR 137
+D D G + Y++ SGD G FT+D+ G + +++LDRE + FY L Q D+
Sbjct: 1969 TDADDGINSQLTYSIASGDSLGQ-FTVDKN-GVLKVLKALDRESQSFYNLVVQVHDL--- 2023
Query: 138 KPLEPESEFIIKVQ------DINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPT 191
P P S F Q D+NDN P FL P + +PE +P+ V + +ATD D
Sbjct: 2024 -PQIPASRFTSTAQVSIILLDVNDNPPTFLS-PKLTYIPENTPIDTVVFKAQATDPDS-- 2079
Query: 192 YGNSARVVYSILQGQPY-FSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLA 250
G ++ + Y++L FSI G +R +DRE Y + + A D G L+
Sbjct: 2080 -GPNSYIEYTLLNPLGNKFSIGTIDGEVRLT-GELDREEVSNYTLTVVATDKGQP--SLS 2135
Query: 251 GTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIVP 310
+T V + + D+NDN P F ++++ +++ E++ G+ I ++ A D D G N ++ Y IV
Sbjct: 2136 SSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVN 2195
Query: 311 GDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTAT 370
G+ F I D+ G I + KPLD E Y V+A++ + P DT+T
Sbjct: 2196 GNTNQEFRI----DSVTGAITVAKPLDREKTPTYHLTVQATD-------RGSTPRTDTST 2244
Query: 371 VKISVLDV-DEPPVFSKPLYTMEVYEDTPVGTI---IGAVTAQDLDVGSSAVRYFIDWKS 426
V I +LD+ D PVF Y++ V E+ +GT+ I V A+D D GS++ ++ +
Sbjct: 2245 VSIVLLDINDFVPVFELSPYSVNVPEN--LGTLPRTILQVVARDDDRGSNSKLSYVLFGG 2302
Query: 427 DGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVLDVNE-F 485
+ D+ FT+ + G + + LDRE+ ++ I A+ +P LT I + V DVN+
Sbjct: 2303 NEDNAFTLSAS-GELGVTQSLDRETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNV 2361
Query: 486 PPEISVPYETAVCENAKPGQIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNFTVRDFRN 545
P S Y T + E+A G + +V+A+D D A + R+ FT+ N
Sbjct: 2362 PTFASKAYFTTIPEDAPTGTDVLLVNASDAD---ASKNAVIRI---IGGNSQFTI----N 2411
Query: 546 NTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTI 587
+ G R ++ Y L VV D+ P S++T +
Sbjct: 2412 PSTGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVL 2453
Score = 174 bits (442), Expect = 2e-43
Identities = 162/543 (29%), Positives = 245/543 (45%), Gaps = 49/543 (9%)
Query: 83 DKGEGT---VKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKP 139
D EGT ++Y L +G T F +D TG I LD E + Y+L QA+D
Sbjct: 276 DADEGTNADIRYRLQDEG--TPFQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVPS- 332
Query: 140 LEPESEFIIKVQDINDNEP--KFLDGPYV---ATVPEMSPVGAYVLQVKATDADDPTYGN 194
L +E +I++ D+NDN+P KF P A+V E + VG V + TDAD P
Sbjct: 333 LTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANG 392
Query: 195 SARVVYSILQG--QPYFSID----PKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGG 248
+ V IL G Q +F + P +I+ A +DRE Y + + D G G
Sbjct: 393 NISV--QILGGNEQRHFEVQSSKVPNLSLIKVASA-LDRERIPSYNLTVSVSDNYGAPPG 449
Query: 249 LA-----GTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNAE 303
A + I + D+ND+PP F + ++ + + E +P GS + I A D D G NA
Sbjct: 450 AAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSGISATDGDSGLNAN 509
Query: 304 IEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKP--LDFETKKAYTFKVEASNLHLDHRFHS 361
+ Y+IV G+G F I G++ LD E + A R
Sbjct: 510 LRYSIVSGNGLGWFHI----SEHSGLVTTGSSGGLDRELASQIVLNISA-------RDQG 558
Query: 362 AGPFKDTATVKISVLDV-DEPPVFSKPL-YTMEVYEDTPVGTIIGAVTAQDLDVG-SSAV 418
P A + +++LDV DE PVFS+P Y + V E+ P GT + + A D D+G + V
Sbjct: 559 VHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTELLMLRATDGDLGDNGTV 618
Query: 419 RYFIDWKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILIN 478
R+ + F +D G ++T LDRE A Y+ ++A+ + +P +S I ++
Sbjct: 619 RFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATDLGSPPQSSMARINVS 678
Query: 479 VLDVNEFPPEI-SVPYETAVCENAKPGQIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPN 537
+LD+N+ P V Y + EN G I VSA D DL G + + S A +
Sbjct: 679 LLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTNG---TVKYSISAGDRSR 735
Query: 538 FTVRDFRNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRVCRCDSDGT 597
F V N +G+ + R R ++ Y L +V D + +TI V +
Sbjct: 736 FQV----NAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNPP 791
Query: 598 ILS 600
+ S
Sbjct: 792 VFS 794
Score = 168 bits (426), Expect = 2e-41
Identities = 139/449 (30%), Positives = 219/449 (48%), Gaps = 28/449 (6%)
Query: 81 DLDKG-EGTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKP 139
D D G G + Y + F+I+ TG+I ++R LDRE+ Y L ++ D P
Sbjct: 2694 DKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSD--KGSP 2751
Query: 140 LEPES-EFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARV 198
+ S + +I + D NDN P+F + A VPE SP+G V +V +D D G +A
Sbjct: 2752 SQSTSVKVMINILDENDNAPRFSQ-IFSAHVPENSPLGYTVTRVTTSDED---IGINAIS 2807
Query: 199 VYSILQGQPYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNIT 258
YSI+ F+I+P TG I + P ++RE ++Y++ + A D G + +T V I
Sbjct: 2808 RYSIMDASLPFTINPSTGDIVISRP-LNREDTDRYRIRVSAHDSGWTV-----STDVTIF 2861
Query: 259 LTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGGNLFD 318
+TD+NDN PRF ++ ++L PE + IGS + ++ A DPD G N ++ Y I +
Sbjct: 2862 VTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSEYFRIN 2921
Query: 319 IVTDEDTQEGVIKLKKPLDFETK--KAYTFKVEASNLHLDHRFHSAGPFKDTATVKISVL 376
T E + ++K + F ++F V +S+ TV I+++
Sbjct: 2922 ATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSD-------RGKPSLISETTVTINIV 2974
Query: 377 DV-DEPPVFSKPLYTMEVYEDTPVGTIIGAVTA-QDLDVG-SSAVRYFIDWKSDGDSYFT 433
D D P F K Y V ++ VGT + VTA D D G +S V YFI + F
Sbjct: 2975 DSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFIS-NDNHLGKFK 3033
Query: 434 IDGNEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPEISVPY 493
+D + G I+ L + + ++ A NP L+S+ + I V + N PE S +
Sbjct: 3034 LDNDTGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQSH 3093
Query: 494 ETA-VCENAKPGQIIQIVSAADRDLSPAG 521
+A + E+ G I++ VSA DRD + G
Sbjct: 3094 MSATIPESHSIGSIVRTVSARDRDAAMNG 3122
Score = 164 bits (415), Expect = 3e-40
Identities = 142/510 (27%), Positives = 226/510 (44%), Gaps = 32/510 (6%)
Query: 80 SDLDKG-EGTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRK 138
SD D G G + YT++ G F I G ++ LDRE + Y L A D +
Sbjct: 1021 SDKDSGANGEIAYTIAEGNTGDAFGIFPD-GQLYIKSELDRELQDRYVLMVVASD-RAVE 1078
Query: 139 PLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARV 198
PL + ++D+NDN P F Y E G++V +V A D D +G + V
Sbjct: 1079 PLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKD---FGPNGEV 1135
Query: 199 VYSILQGQPYFSIDPKTGVIRTALPNMDREVKEQ------YQVLIQAKDMGGQLGGLAGT 252
YS QP F + +G I T DRE + + + A D G L
Sbjct: 1136 RYSFEMVQPDFELHAISGEI-TNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQP-LKDQ 1193
Query: 253 TIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPGD 312
V++ + D+NDN P+F K + + ES+ + + R+ A D D G N I Y+I+ G+
Sbjct: 1194 ATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGN 1253
Query: 313 GGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTATVK 372
F I D+ G + L LD+E AY+ ++A + P T T+
Sbjct: 1254 EERQFAI----DSTSGQVTLIGKLDYEATPAYSLVIQAVD-------SGTIPLNSTCTLN 1302
Query: 373 ISVLDV-DEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRYFIDWKSDGDSY 431
I +LD D P F K ++V E+ +G ++ +VTA D D G +A Y+ ++
Sbjct: 1303 IDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGT 1362
Query: 432 FTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPEISV 491
F+I N G+I + LD E+ + Y +I A P +S ++++I+V D N+ PP
Sbjct: 1363 FSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPP 1422
Query: 492 -PYETAVCENAKPGQIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNFTVRDFRNNTAGI 550
++ EN G + V+A D D G Q S+ + + +FT+ + + G
Sbjct: 1423 GDIFKSIVENIPIGTSVISVTAHDPDADING-QLSYTIIQQMPRGNHFTIDEVK----GT 1477
Query: 551 ETRRNGYSRRQQELYFLPVVIEDSSYPVQS 580
R L+ L V D + P+++
Sbjct: 1478 IYTNAEIDREFANLFELTVKANDQAVPIET 1507
Score = 164 bits (415), Expect = 3e-40
Identities = 147/517 (28%), Positives = 235/517 (45%), Gaps = 29/517 (5%)
Query: 89 VKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFII 148
V+Y +S D F +D TG I SL + + + A D + PL ++ I
Sbjct: 3019 VEYFISNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKD-KGNPPLSSQATVHI 3077
Query: 149 KVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQG--Q 206
V + N + P+F AT+PE +G+ V V A D D G + YSI G +
Sbjct: 3078 TVTEENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNG---LIKYSISSGNEE 3134
Query: 207 PYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNP 266
F+I+ TG++ T +D E+ +++++ I A D GG + G V + + DVNDN
Sbjct: 3135 GIFAINSSTGIL-TLAKALDYELCQKHEMTISAID-GGWVAR-TGYCSVTVNVIDVNDNS 3191
Query: 267 PRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGGNLFDIVTDEDTQ 326
P F + V E++P G+ + + A D D G NA I Y + D +LF I D
Sbjct: 3192 PVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDS-DLFVI----DPN 3246
Query: 327 EGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTATVKISVLDVDE-PPVFS 385
GVI + LDFETK++Y V+A N+ + R ATV I + +E P F
Sbjct: 3247 TGVITTQGFLDFETKQSYHLTVKAFNVPDEERC-------SFATVNIQLKGTNEYVPRFV 3299
Query: 386 KPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRYFIDWKSDGDSYFTIDGNEGTIATNE 445
LY E+ E P GTI+G V A D D+G+ +++ + + F I+ G I +
Sbjct: 3300 SKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSG 3359
Query: 446 LLDRESTAQYNFSIIASKVSN--PLLTSKVNILINVLDVNEFPPEISVPYETAVCENAKP 503
+LDRE + + ++A + +V + + VLD N+ P Y + E
Sbjct: 3360 ILDREKEERVSLKVLAKNFGSIRGADIDEVTVNVTVLDANDPPIFTLNIYSVQISEGVPI 3419
Query: 504 GQIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNFTVRDFRNNTAGIETRRNGYSRRQQE 563
G + VSA D D P+ +FS+ + F++ N G T R
Sbjct: 3420 GTHVTFVSAFDSDSIPSWSRFSYFIG-SGNENGAFSI----NPQTGQITVTAELDRETLP 3474
Query: 564 LYFLPVVIEDSSYPVQSSTNTMTIRVCRCDSDGTILS 600
+Y L V+ DS P + + ++ + + + +G +L+
Sbjct: 3475 IYNLSVLAVDSGTPSATGSASLLVTLEDINDNGPMLT 3511
Score = 163 bits (413), Expect = 5e-40
Identities = 163/585 (27%), Positives = 256/585 (43%), Gaps = 51/585 (8%)
Query: 13 VLFDGGLLTPLQPQPQQTLATEPRENVIHLPGQRSHFQRVKRGWVWNQFFVLEEYVGSEP 72
V DGG L P Q + T V+ F +V +V + L +VGS
Sbjct: 764 VATDGGNLQ----SPNQAIVTI---TVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVS 816
Query: 73 QYVGKLHSDLDKGEGTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAV 132
L+S+ + Y ++ +F I++ TG + +DREE+ FY L+ A
Sbjct: 817 ASTMDLNSN-------ISYLITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVA- 868
Query: 133 DIETRKPLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTY 192
+ + ++ I V+D+NDN P FL V E G + Q KA D D+
Sbjct: 869 ---SGGTVTGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDE--- 922
Query: 193 GNSARVVYSILQG-QPYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAG 251
G + V+YS+ Q + F+I+ K G I P +D YQ+ I A DMG + L+
Sbjct: 923 GVNGMVLYSLKQNPKNLFAINEKNGTISLLGP-LDVHAGS-YQIEILASDMG--VPQLSS 978
Query: 252 TTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPG 311
+ I+ + + DVNDN P F + + + + ES P+ S +++A D D G N EI Y I G
Sbjct: 979 SVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEG 1038
Query: 312 DGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTATV 371
+ G+ F I D G + +K LD E + Y V AS+ + P T V
Sbjct: 1039 NTGDAFGIFPD-----GQLYIKSELDRELQDRYVLMVVASD-------RAVEPLSATVNV 1086
Query: 372 KISVLDV-DEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVG-SSAVRYFIDWKSDGD 429
+ + DV D P+F+ YT E+ G+ +G V+A D D G + VRY +
Sbjct: 1087 TVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSFEMVQPDF 1146
Query: 430 SYFTIDG---NEGTIATNELLDRESTAQYNFSIIASKVSNPL-LTSKVNILINVLDVNEF 485
I G N L+ R TA ++F++IA+ P L + + + + D+N+
Sbjct: 1147 ELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMKDINDN 1206
Query: 486 PPE-ISVPYETAVCENAKPGQIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNFTVRDFR 544
P+ + Y+ + E+A + VSA+D D G L + IK N +
Sbjct: 1207 APKFLKDFYQATISESAANLTQVLRVSASDVDEGNNG------LIHYSIIKGNEERQFAI 1260
Query: 545 NNTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRV 589
++T+G T Y L + DS +ST T+ I +
Sbjct: 1261 DSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDI 1305
Score = 157 bits (396), Expect = 5e-38
Identities = 163/566 (28%), Positives = 247/566 (43%), Gaps = 64/566 (11%)
Query: 80 SDLDKGEGT-VKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRK 138
+D D G+ + Y+++G F+I TG I + LD E + Y L A D + R
Sbjct: 1340 TDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKD-QGRP 1398
Query: 139 PLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARV 198
P +I V+D NDN P F G ++ E P+G V+ V A D D G ++
Sbjct: 1399 PRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDADING---QL 1455
Query: 199 VYSILQGQP---YFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLA-GTTI 254
Y+I+Q P +F+ID G I T +DRE +++ ++A D +
Sbjct: 1456 SYTIIQQMPRGNHFTIDEVKGTIYTNA-EIDREFANLFELTVKANDQAVPIETRRYALKN 1514
Query: 255 VNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGG 314
V I +TD+NDN P F S L S+ IGS + I A DPD G N EIEY I+ GD
Sbjct: 1515 VTILVTDLNDNVPMFI-SQNALAADPSAVIGSVLTTIMAADPDEGANGEIEYEIINGDTD 1573
Query: 315 NLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTATVKIS 374
D G +++ L ++ Y V A++L GP + +T +++
Sbjct: 1574 TFI-----VDRYSGDLRVASAL-VPSQLIYNLIVSATDL---------GPERRKSTTELT 1618
Query: 375 -VLDVDEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRYFI-----DWKSDG 428
+L + PVF++P Y + E P+GT + ++ A + V Y+I + K+ G
Sbjct: 1619 IILQGLDGPVFTQPKYITILKEGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKTVG 1678
Query: 429 DSYFTIDGNEGTIATNELLDRESTA-QYNFSIIASKVSNPL-LTSKVNILINVLDVNEFP 486
FTI + G I T +LDRE A Y + A + S T + + I + D+N+ P
Sbjct: 1679 -RLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNP 1737
Query: 487 PEISVP-YETAVCENAKPGQIIQIVSAADRDLSP---------AGQQFSFRLSPEAAIKP 536
P + V EN G I ++A D D +G SFR+ PE+
Sbjct: 1738 PVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGADDSFRIDPESGDL- 1796
Query: 537 NFTVRDFRNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRVCRCDSDG 596
I TRR RR + Y L V +D +QSS + I V +
Sbjct: 1797 -------------IATRRLDRERRSK--YSLLVRADDG---LQSSDMRINITVSDVNDHT 1838
Query: 597 TILSCNVEAIFLPVGLSTGALIAILL 622
S V + +P G+L+A +L
Sbjct: 1839 PKFSRPVYSFDIPEDTIPGSLVAAIL 1864
Score = 155 bits (393), Expect = 1e-37
Identities = 145/504 (28%), Positives = 222/504 (44%), Gaps = 39/504 (7%)
Query: 80 SDLDKGEGTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKP 139
SD D + V + G+ FTI+ +TG I LDRE K YTL D + +P
Sbjct: 2389 SDADASKNAVIRIIGGNSQ---FTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSPEP 2445
Query: 140 LEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARVV 199
L + ++ V D+NDN P+F PYV +P + G++V V TDAD G ++ +
Sbjct: 2446 LSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDAD---IGPNSELH 2502
Query: 200 YSIL-QGQPYFSIDPKTGVIRTALP-NMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNI 257
YS+ + F IDP G I A P N EV + KD GG TT+
Sbjct: 2503 YSLSGRNSEKFHIDPLRGAIMAAGPLNGASEV----TFSVHVKD-GGSFPKTDSTTVTVR 2557
Query: 258 TLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGGNLF 317
+ + R + F PE+ P+ S + I + + Y I G+ GN F
Sbjct: 2558 FVNKADFPKVRAKEQTF--MFPENQPVSSLVTTITGSSL---RGEPMSYYIASGNLGNTF 2612
Query: 318 DIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTATVKISVLD 377
I D G + + +PLDFE + Y +EA R PF + I+VLD
Sbjct: 2613 QI----DQLTGQVSISQPLDFEKIQKYVVWIEA-------RDGGFPPFSSYEKLDITVLD 2661
Query: 378 V-DEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRYFIDWKSDGDSYFTIDG 436
V D P+F + + E+ E+ I+ V+A D D G + + + ++ F+I+
Sbjct: 2662 VNDNAPIFKEDPFISEILENLSPRKIL-TVSAMDKDSGPNGQLDYEIVNGNMENSFSINH 2720
Query: 437 NEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPEISVPYETA 496
G I + LDRE + Y +I +S +P ++ V ++IN+LD N+ P S +
Sbjct: 2721 ATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDENDNAPRFSQIFSAH 2780
Query: 497 VCENAKPGQIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNFTVRDFRNNTAGIETRRNG 556
V EN+ G + V+ +D D+ G R S A P FT+ N + G
Sbjct: 2781 VPENSPLGYTVTRVTTSDEDI---GINAISRYSIMDASLP-FTI----NPSTGDIVISRP 2832
Query: 557 YSRRQQELYFLPVVIEDSSYPVQS 580
+R + Y + V DS + V +
Sbjct: 2833 LNREDTDRYRIRVSAHDSGWTVST 2856
Score = 154 bits (389), Expect = 3e-37
Identities = 138/484 (28%), Positives = 218/484 (45%), Gaps = 58/484 (11%)
Query: 69 GSEPQYVGKLHSDLDKGE--GTVK------YTLSGDGAGTVFTIDETTGDIHAIRSLDRE 120
G+EP+ V ++ + G GT++ Y LS A +F I+ +TG ++ ++DRE
Sbjct: 42 GAEPRQVFQVLEEQPPGTLVGTIQTRPGFTYRLSESHA--LFAINSSTGALYTTSTIDRE 99
Query: 121 EKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVL 180
P + + P E + V+D+NDN P F D V T E S G V+
Sbjct: 100 SLPSDVINLVVLSSAPTYPTEVR----VLVRDLNDNAPVFPDPSIVVTFKEDSSSGRQVI 155
Query: 181 QVKATDADDPTYGNSARVVYSILQGQPY------FSIDPK---TGVIRTALPNMDREVKE 231
ATD+D + G R Y I++G +++P + + +DREV
Sbjct: 156 LDTATDSDIGSNGVDHRS-YRIIRGNEAGRFRLDITLNPSGEGAFLHLVSKGGLDREVTP 214
Query: 232 QYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRI 291
QYQ+L++ +D G G VN+T+ D+NDNPP F S + VPE + +GS++ ++
Sbjct: 215 QYQLLVEVEDKGEPKR--RGYLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQV 272
Query: 292 RAVDPDFGQNAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEAS 351
A D D G NA+I Y + D G F + D + G+I +++PLDFE ++ Y+ V+A
Sbjct: 273 AAADADEGTNADIRYRL--QDEGTPFQM----DPETGLITVREPLDFEARRQYSLTVQAM 326
Query: 352 NLHLDHRFHSAGPFKDTATVKISVLDV-DEPPV-----FSKPLYTMEVYEDTPVGTIIGA 405
+ A I +LDV D PV F V E+ VGT++
Sbjct: 327 D-------RGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVAL 379
Query: 406 VTAQDLDVGSSAVRYFIDWKSDGDS-YFTIDG----NEGTIATNELLDRESTAQYNFSII 460
+T D D ++ + + +F + N I LDRE YN ++
Sbjct: 380 LTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRERIPSYNLTVS 439
Query: 461 ASK-------VSNPLLTSKVNILINVLDVNEFPPEISVP-YETAVCENAKPGQIIQIVSA 512
S + +S +++I V D+N+ PP S Y + E A PG + +SA
Sbjct: 440 VSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSGISA 499
Query: 513 ADRD 516
D D
Sbjct: 500 TDGD 503
Score = 145 bits (365), Expect = 2e-34
Identities = 145/528 (27%), Positives = 229/528 (43%), Gaps = 51/528 (9%)
Query: 80 SDLDKG-EGTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDI--ET 136
+D D+G G ++Y + T F +D +GD+ +L + Y L A D+ E
Sbjct: 1553 ADPDEGANGEIEYEIINGDTDT-FIVDRYSGDLRVASALVPSQL-IYNLIVSATDLGPER 1610
Query: 137 RKPLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSA 196
RK +E I +Q ++ P F Y+ + E P+G V+ ++A G+ A
Sbjct: 1611 RKST---TELTIILQGLDG--PVFTQPKYITILKEGEPIGTNVISIEAASPR----GSEA 1661
Query: 197 RVVYSILQGQ-------PYFSIDPKTGVIRTALPNMDREVKE-QYQVLIQAKDMGGQLGG 248
V Y I+ + F+I TG+I+TA +DRE Y V + A +
Sbjct: 1662 PVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAI-LDREQGACLYLVDVYAIEKSTAFPR 1720
Query: 249 LAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNI 308
V ITL D+NDNPP FP + L V E+ GS I ++ A+D D G NA + Y I
Sbjct: 1721 TQRAE-VEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTI 1779
Query: 309 VPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDT 368
+ G + F I D + G + + LD E + Y+ V A + G
Sbjct: 1780 ISG-ADDSFRI----DPESGDLIATRRLDRERRSKYSLLVRADD----------GLQSSD 1824
Query: 369 ATVKISVLDV-DEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRYFIDWKSD 427
+ I+V DV D P FS+P+Y+ ++ EDT G+++ A+ A D D G + +I + D
Sbjct: 1825 MRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDD 1884
Query: 428 GDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPP 487
D F ++ G LLD E Y ++ A T + + N+LDVN+ PP
Sbjct: 1885 EDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGGQFTT--IRVYFNILDVNDNPP 1942
Query: 488 EISV-PYETAVCENAKPGQIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNFTVRDFRNN 546
S+ Y T++ EN G + + + D D Q ++ +I ++ F +
Sbjct: 1943 IFSLNSYSTSLMENLPVGSTVLVFNVTDAD-DGINSQLTY------SIASGDSLGQFTVD 1995
Query: 547 TAGIETRRNGYSRRQQELYFLPVVIED-SSYPVQSSTNTMTIRVCRCD 593
G+ R Q Y L V + D P T+T + + D
Sbjct: 1996 KNGVLKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLD 2043
Score = 123 bits (309), Expect = 6e-28
Identities = 123/449 (27%), Positives = 206/449 (45%), Gaps = 35/449 (7%)
Query: 80 SDLDKGEGTV-KYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRK 138
+D D G V YT+ + +F ID TG I LD E K Y L +A ++
Sbjct: 3219 TDADSGTNAVIAYTVQSSDSD-LFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNV---- 3273
Query: 139 PLEPESEFI---IKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNS 195
P E F I+++ N+ P+F+ Y + E +P G V +V A+D D T G
Sbjct: 3274 PDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEV 3333
Query: 196 ARVVYSILQGQPYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIV 255
+++ + + F I+ KTG I + +DRE +E+ + + AK+ G G V
Sbjct: 3334 HYLIFGNSRKKG-FQINKKTGQIYVS-GILDREKEERVSLKVLAKNFGSIRGADIDEVTV 3391
Query: 256 NITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQN-AEIEYNIVPGDGG 314
N+T+ D ND PP F +I+ +++ E PIG+ + + A D D + + Y I G+
Sbjct: 3392 NVTVLDAND-PPIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNEN 3450
Query: 315 NLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTATVKIS 374
F I + Q G I + LD ET Y V L +D SA +A++ ++
Sbjct: 3451 GAFSI----NPQTGQITVTAELDRETLPIYNLSV----LAVDSGTPSA---TGSASLLVT 3499
Query: 375 VLDVDEPPVFSKPLYTM---EVYEDTPVGTIIGAVTAQDLDV--GSSAVRYFIDWKSDGD 429
+ D+++ + P+ T+ EV E+ GT++ + + D D+ Y++
Sbjct: 3500 LEDIND----NGPMLTVSEGEVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPAT 3555
Query: 430 SYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPEI 489
SYF++ G ++T +DRE A + S++ P ++S + I V+D N+ P +
Sbjct: 3556 SYFSLS-TAGVLSTTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQNDNPSQS 3614
Query: 490 -SVPYETAVCENAKPGQIIQIVSAADRDL 517
+V N PG I+ V D D+
Sbjct: 3615 RTVEIFVNYYGNLFPGGILGSVKPQDPDV 3643
Score = 120 bits (300), Expect = 6e-27
Identities = 144/522 (27%), Positives = 224/522 (42%), Gaps = 51/522 (9%)
Query: 80 SDLDKGEGT-VKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRK 138
+D D G + + Y+LSG + F ID G I A L+ + ++ V ++
Sbjct: 2491 TDADIGPNSELHYSLSGRNSEK-FHIDPLRGAIMAAGPLNGASEVTFS-----VHVKDGG 2544
Query: 139 PLEPESEFIIKVQDINDNE-PKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSAR 197
+ V+ +N + PK PE PV + V + G+S R
Sbjct: 2545 SFPKTDSTTVTVRFVNKADFPKVRAKEQTFMFPENQPVSSLVTTIT---------GSSLR 2595
Query: 198 ---VVYSILQGQ--PYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGT 252
+ Y I G F ID TG + + P +D E ++Y V I+A+D G +
Sbjct: 2596 GEPMSYYIASGNLGNTFQIDQLTGQVSISQP-LDFEKIQKYVVWIEARD--GGFPPFSSY 2652
Query: 253 TIVNITLTDVNDNPPRFPKSIFHLKVPES-SPIGSAIGRIRAVDPDFGQNAEIEYNIVPG 311
++IT+ DVNDN P F + F ++ E+ SP I + A+D D G N +++Y IV G
Sbjct: 2653 EKLDITVLDVNDNAPIFKEDPFISEILENLSP--RKILTVSAMDKDSGPNGQLDYEIVNG 2710
Query: 312 DGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTAT- 370
+ N F I + G I+ +PLD E Y +++S+ P + T+
Sbjct: 2711 NMENSFSI----NHATGEIRSVRPLDREKVSHYVLTIKSSD--------KGSPSQSTSVK 2758
Query: 371 VKISVLDV-DEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAV-RYFIDWKSDG 428
V I++LD D P FS+ +++ V E++P+G + VT D D+G +A+ RY I D
Sbjct: 2759 VMINILDENDNAPRFSQ-IFSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSI---MDA 2814
Query: 429 DSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPE 488
FTI+ + G I + L+RE T +Y + A T ++ I V D+N+ P
Sbjct: 2815 SLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSG---WTVSTDVTIFVTDINDNAPR 2871
Query: 489 IS-VPYETAVCENAKPGQIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNFTVRDFRNNT 547
S Y E + G + V A D D GQ F F S + N T + N
Sbjct: 2872 FSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSEYFRINATTGEIFNKQ 2931
Query: 548 AGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRV 589
G+S + V D P S T+TI +
Sbjct: 2932 ILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINI 2973
Score = 76.3 bits (186), Expect = 1e-13
Identities = 66/233 (28%), Positives = 98/233 (42%), Gaps = 12/233 (5%)
Query: 68 VGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTL 127
+G+ +V SD Y + F+I+ TG I LDRE P Y L
Sbjct: 3419 IGTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNL 3478
Query: 128 RAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDA 187
AVD T S ++ ++DINDN P V E G V+ +++TD
Sbjct: 3479 SVLAVDSGTPSATGSAS-LLVTLEDINDNGPMLTVSE--GEVMENKRPGTLVMTLQSTDP 3535
Query: 188 DDPTYGNSARVVYSILQGQP---YFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGG 244
D P N Y +L P YFS+ GV+ T +DRE + + + KD G
Sbjct: 3536 DLPP--NQGPFTYYLLSTGPATSYFSLS-TAGVLSTT-REIDREQIADFYLSVVTKDSG- 3590
Query: 245 QLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPD 297
+ ++ T V+IT+ D NDNP + + + G +G ++ DPD
Sbjct: 3591 -VPQMSSTGTVHITVIDQNDNPSQSRTVEIFVNYYGNLFPGGILGSVKPQDPD 3642
>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
sapiens]
Length = 2923
Score = 206 bits (523), Expect = 9e-53
Identities = 150/450 (33%), Positives = 223/450 (49%), Gaps = 32/450 (7%)
Query: 81 DLDKGE-GTVKYTLSG---DGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVD--I 134
D D+GE G ++YT+ + F++D TG + LDRE K + R A D +
Sbjct: 207 DPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGM 266
Query: 135 ETRKPLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGN 194
R L + I V D ND++P F Y ++ E VG VL V+ATD D P
Sbjct: 267 PRRSAL---ATLTILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPP--- 320
Query: 195 SARVVYSILQGQ-----PYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGL 249
+A ++Y +L+G F IDP++GVIRT P +DRE E YQ+ ++A D G G
Sbjct: 321 NANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGP-VDREEVESYQLTVEASDQGRDPGPR 379
Query: 250 AGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIV 309
+ T V +++ D NDN P+F + + ++V E G+ + R+ A D D G NA + Y+I+
Sbjct: 380 STTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIM 439
Query: 310 PGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKD-T 368
G+ F + D Q G + + PLD+ET K YT +V A + P + +
Sbjct: 440 SGNARGQFYL----DAQTGALDVVSPLDYETTKEYTLRVRAQD-------GGRPPLSNVS 488
Query: 369 ATVKISVLDV-DEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRYFIDWKSD 427
V + VLD+ D P+F + V E P+G ++ V A D D G +A +
Sbjct: 489 GLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVG 548
Query: 428 GDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPP 487
D FTI+ G I+ LDRE Y+F + A P LT+ ++ + VLDVN+ P
Sbjct: 549 HDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNP 608
Query: 488 EISVP-YETAVCENAKPGQIIQIVSAADRD 516
+ P Y + E+A G + VSA DRD
Sbjct: 609 TFTQPEYTVRLNEDAAVGTSVVTVSAVDRD 638
Score = 172 bits (436), Expect = 1e-42
Identities = 139/444 (31%), Positives = 204/444 (45%), Gaps = 33/444 (7%)
Query: 81 DLDKGEGT-VKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKP 139
D D G+ ++Y L+G G FTI+ TG I LDREE FY+ +A D T
Sbjct: 531 DADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGT-PA 589
Query: 140 LEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARVV 199
L + + V D+NDN P F Y + E + VG V+ V A D D + +
Sbjct: 590 LTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSV-----IT 644
Query: 200 YSILQGQPY--FSIDPKTG--VIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIV 255
Y I G FSI ++G ++ ALP +D +++ QY + + A D G T +
Sbjct: 645 YQITSGNTRNRFSITSQSGGGLVSLALP-LDYKLERQYVLAVTASD-----GTRQDTAQI 698
Query: 256 NITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGGN 315
+ +TD N + P F S + + V E P G+ + I A D D G+NA I Y + D
Sbjct: 699 VVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFME--DSIP 756
Query: 316 LFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTATVKISV 375
F I D G + + LD+E + +YT + A + + + DT ++I V
Sbjct: 757 QFRI----DADTGAVTTQAELDYEDQVSYTLAITARDNGIPQK-------SDTTYLEILV 805
Query: 376 LDV-DEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVG-SSAVRYFIDWKSDGDSYFT 433
DV D P F + Y VYED P T + ++A D D G + V Y DGD F
Sbjct: 806 NDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFI 865
Query: 434 IDGNEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPEISV-P 492
++ G + T LDRE+ AQY A P + + + + VLDVN+ PP
Sbjct: 866 VESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDE 925
Query: 493 YETAVCENAKPGQIIQIVSAADRD 516
++ V EN+ G + V+A D D
Sbjct: 926 FDVFVEENSPIGLAVARVTATDPD 949
Score = 171 bits (432), Expect = 3e-42
Identities = 131/440 (29%), Positives = 212/440 (48%), Gaps = 26/440 (5%)
Query: 158 PKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSI-----LQGQPYFSID 212
P+F Y ATVPE P G V ++A D D+ G + R+ Y++ + +FS+D
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDPDE---GEAGRLEYTMDALFDSRSNQFFSLD 235
Query: 213 PKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKS 272
P TG + TA +DRE K + + A+D G + + + I +TD ND+ P F +
Sbjct: 236 PVTGAVTTA-EELDRETKSTHVFRVTAQDHG--MPRRSALATLTILVTDTNDHDPVFEQQ 292
Query: 273 IFHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKL 332
+ + E+ +G + +RA D D NA I Y ++ G GG+ + V + D + GVI+
Sbjct: 293 EYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSE-VFEIDPRSGVIRT 351
Query: 333 KKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTATVKISVL-DVDEPPVFSKPLYTM 391
+ P+D E ++Y VEAS+ D GP TA V +SV D D P FS+ Y +
Sbjct: 352 RGPVDREEVESYQLTVEASDQGRD-----PGPRSTTAAVFLSVEDDNDNAPQFSEKRYVV 406
Query: 392 EVYEDTPVGTIIGAVTAQDLDVGSSAVRYFIDWKSDGDSYFTIDGNEGTIATNELLDRES 451
+V ED G + VTA D D GS+AV ++ + F +D G + LD E+
Sbjct: 407 QVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYET 466
Query: 452 TAQYNFSIIASKVSNPLLTSKVNIL-INVLDVNEFPP-EISVPYETAVCENAKPGQIIQI 509
T +Y + A P L++ ++ + VLD+N+ P +S P++ V E+ G ++
Sbjct: 467 TKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLH 526
Query: 510 VSAADRDLSPAGQQFSFRLSPEAAIKPNFTVRDFRNNTAGIETRRNGYSRRQQELYFLPV 569
V A D D + +RL+ P FT+ NN G + R + + Y V
Sbjct: 527 VQAIDADAGD-NARLEYRLAGVGHDFP-FTI----NNGTGWISVAAELDREEVDFYSFGV 580
Query: 570 VIEDSSYPVQSSTNTMTIRV 589
D P +++ ++++ V
Sbjct: 581 EARDHGTPALTASASVSVTV 600
Score = 150 bits (379), Expect = 4e-36
Identities = 131/486 (26%), Positives = 217/486 (44%), Gaps = 45/486 (9%)
Query: 70 SEPQYVGKLHSDLDKGEGTVKYTLSGDGAGTVFTIDETTGD---------------IHAI 114
++P+Y +L+ D G V + A +V T T+G+ +
Sbjct: 611 TQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLA 670
Query: 115 RSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSP 174
LD + + Y L A D TR + ++ ++ V D N + P F Y V E P
Sbjct: 671 LPLDYKLERQYVLAVTASD-GTR---QDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRP 726
Query: 175 VGAYVLQVKATDADDPTYGNSARVVYSILQGQPYFSIDPKTGVIRTALPNMDREVKEQYQ 234
G V+ + ATD D G +AR+ Y + P F ID TG + T +D E + Y
Sbjct: 727 AGTTVVLISATDEDT---GENARITYFMEDSIPQFRIDADTGAV-TTQAELDYEDQVSYT 782
Query: 235 VLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAV 294
+ I A+D G + + TT + I + DVNDN P+F + + V E P +++ +I A
Sbjct: 783 LAITARDNG--IPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISAT 840
Query: 295 DPDFGQNAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLH 354
D D G N + Y GD G+ IV ++ G+++ + LD E Y + A +
Sbjct: 841 DRDSGLNGRVFYTFQGGDDGDGDFIV---ESTSGIVRTLRRLDRENVAQYVLRAYAVDKG 897
Query: 355 LDHRFHSAGPFKDTATVKISVLDV-DEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDV 413
+ P + V ++VLDV D PPVF + + + V E++P+G + VTA D D
Sbjct: 898 MP-------PARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDE 950
Query: 414 GSSAVRYFIDWKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKV 473
G++A + + + F +D G + LD E +Y ++ + ++ L S+
Sbjct: 951 GTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEY---VLVIQATSAPLVSRA 1007
Query: 474 NILINVLDVNEFPP---EISVPYETAVCENAK--PGQIIQIVSAADRDLSPAGQQFSFRL 528
+ + +LD N+ PP + + V + PG I V A D D+S + +SF
Sbjct: 1008 TVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDS-LTYSFER 1066
Query: 529 SPEAAI 534
E ++
Sbjct: 1067 GNELSL 1072
Score = 143 bits (360), Expect = 7e-34
Identities = 122/392 (31%), Positives = 180/392 (45%), Gaps = 34/392 (8%)
Query: 80 SDLDKGEGTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKP 139
+D D GE + T + + F ID TG + LD E++ YTL A D P
Sbjct: 737 TDEDTGENA-RITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARD--NGIP 793
Query: 140 LEPESEFI-IKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARV 198
+ ++ ++ I V D+NDN P+FL Y +V E P VLQ+ ATD D G + RV
Sbjct: 794 QKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDS---GLNGRV 850
Query: 199 VYSIL---QGQPYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIV 255
Y+ G F ++ +G++RT L +DRE QY + A D G + V
Sbjct: 851 FYTFQGGDDGDGDFIVESTSGIVRT-LRRLDRENVAQYVLRAYAVDKG--MPPARTPMEV 907
Query: 256 NITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGGN 315
+T+ DVNDNPP F + F + V E+SPIG A+ R+ A DPD G NA+I Y IV G+
Sbjct: 908 TVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPE 967
Query: 316 LFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTATVKISV 375
+F + D G + LD+E + Y ++A ++ P ATV + +
Sbjct: 968 VFQL----DIFSGELTALVDLDYEDRPEYVLVIQA----------TSAPLVSRATVHVRL 1013
Query: 376 LD-VDEPPVFSKPLYTMEVY----EDTPVGTIIGAVTAQDLDVGSSAVRYFIDWKSDGDS 430
LD D PPV Y + G IG V A D D+ S F + + S
Sbjct: 1014 LDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSF--ERGNELS 1071
Query: 431 YFTIDGNEGTIATNELLDRESTAQYNFSIIAS 462
++ + G + + LD + S++ S
Sbjct: 1072 LVLLNASTGELKLSRALDNNRPLEAIMSVLVS 1103
Score = 66.2 bits (160), Expect = 1e-10
Identities = 59/224 (26%), Positives = 96/224 (42%), Gaps = 8/224 (3%)
Query: 377 DVDEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSA-VRYFID--WKSDGDSYFT 433
+V+ P F P Y V E+ P GT + ++ A D D G + + Y +D + S + +F+
Sbjct: 174 NVNTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFS 233
Query: 434 IDGNEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPEI-SVP 492
+D G + T E LDRE+ + + F + A P ++ + I V D N+ P
Sbjct: 234 LDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQE 293
Query: 493 YETAVCENAKPGQIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNFTVRDFRNNTAGIET 552
Y+ ++ EN + G + V A D D +P +RL + P+ + +G+
Sbjct: 294 YKESLRENLEVGYEVLTVRATDGD-APPNANILYRLLEGSGGSPSEVFE--IDPRSGVIR 350
Query: 553 RRNGYSRRQQELYFLPVVIEDSSY-PVQSSTNTMTIRVCRCDSD 595
R R + E Y L V D P ST D+D
Sbjct: 351 TRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDND 394
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.136 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,608,764
Number of Sequences: 37866
Number of extensions: 1488482
Number of successful extensions: 8567
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 198
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 3387
Number of HSP's gapped (non-prelim): 873
length of query: 794
length of database: 18,247,518
effective HSP length: 110
effective length of query: 684
effective length of database: 14,082,258
effective search space: 9632264472
effective search space used: 9632264472
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.