Search of human proteins with 157743261

Search of human proteins with 157743261

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|157743261 tripartite motif-containing 75 [Homo sapiens]
         (468 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|157743261 tripartite motif-containing 75 [Homo sapiens]            959   0.0  
gi|22749269 ring finger protein 129 [Homo sapiens]                    431   e-121
gi|25777698 tripartite motif-containing 39 isoform 2 [Homo sapiens]   390   e-108
gi|25777696 tripartite motif-containing 39 isoform 1 [Homo sapiens]   379   e-105
gi|5730009 ret finger protein [Homo sapiens]                          279   3e-75
gi|21630277 tripartite motif-containing 11 [Homo sapiens]             278   6e-75
gi|112421127 tripartite motif-containing 58 [Homo sapiens]            276   2e-74
gi|37622899 ring finger protein 137 [Homo sapiens]                    270   2e-72
gi|15208660 tripartite motif protein 21 [Homo sapiens]                269   4e-72
gi|15011941 tripartite motif protein TRIM4 isoform beta [Homo sa...   250   2e-66
gi|68160933 tripartite motif-containing 17 isoform 1 [Homo sapiens]   246   3e-65
gi|7705825 tripartite motif-containing 17 isoform 1 [Homo sapiens]    246   3e-65
gi|157426898 tripartite motif-containing 10 isoform 1 [Homo sapi...   242   6e-64
gi|14670266 tripartite motif protein TRIM4 isoform alpha [Homo s...   241   1e-63
gi|44680122 tripartite motif-containing 7 isoform 1 [Homo sapiens]    229   4e-60
gi|5454014 tripartite motif-containing 38 [Homo sapiens]              228   7e-60
gi|31542779 tripartite motif family-like 1 [Homo sapiens]             226   4e-59
gi|18079262 tripartite motif-containing 6 isoform 2 [Homo sapiens]    218   9e-57
gi|51477692 tripartite motif-containing 6 isoform 1 [Homo sapiens]    218   9e-57
gi|68160935 tripartite motif-containing 17 isoform 2 [Homo sapiens]   218   1e-56
gi|42516572 tripartite motif-containing 41 isoform 1 [Homo sapiens]   214   2e-55
gi|149193331 tripartite motif protein 15 [Homo sapiens]               205   8e-53
gi|88999601 tripartite motif-containing 69 isoform a [Homo sapiens]   199   3e-51
gi|157426896 tripartite motif-containing 10 isoform 2 [Homo sapi...   196   3e-50
gi|60099474 tripartite motif-containing 61 [Homo sapiens]             192   4e-49
gi|51477687 tripartite motif protein 34 isoform 1 [Homo sapiens]      192   7e-49
gi|18087807 tripartite motif protein 34 isoform 1 [Homo sapiens]      192   7e-49
gi|51477690 tripartite motif-containing 6 and tripartite motif-c...   192   7e-49
gi|4557743 Mediterranean fever protein [Homo sapiens]                 191   9e-49
gi|4508005 tripartite motif-containing 26 [Homo sapiens]              189   6e-48

>gi|157743261 tripartite motif-containing 75 [Homo sapiens]
          Length = 468

 Score =  959 bits (2478), Expect = 0.0
 Identities = 468/468 (100%), Positives = 468/468 (100%)

Query: 1   MAVAAALTGLQAEAKCSICLDYLSDPVTIECGHNFCRSCIQQSWLDLQELFPCPVCRHQC 60
           MAVAAALTGLQAEAKCSICLDYLSDPVTIECGHNFCRSCIQQSWLDLQELFPCPVCRHQC
Sbjct: 1   MAVAAALTGLQAEAKCSICLDYLSDPVTIECGHNFCRSCIQQSWLDLQELFPCPVCRHQC 60

Query: 61  QEGHFRSNTQLGRMIEIAKLLQSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMVLCPLCT 120
           QEGHFRSNTQLGRMIEIAKLLQSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMVLCPLCT
Sbjct: 61  QEGHFRSNTQLGRMIEIAKLLQSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMVLCPLCT 120

Query: 121 QPPDHQGHHVRPIEKAAIHYRKRFCSYIQPLKKQLADLQKLISTQSKKPLELREMVENQR 180
           QPPDHQGHHVRPIEKAAIHYRKRFCSYIQPLKKQLADLQKLISTQSKKPLELREMVENQR
Sbjct: 121 QPPDHQGHHVRPIEKAAIHYRKRFCSYIQPLKKQLADLQKLISTQSKKPLELREMVENQR 180

Query: 181 QELSSEFEHLNQFLDREQQAVLSRLAEEEKDNQQKLSANITAFSNYSATLKSQLSKVVEL 240
           QELSSEFEHLNQFLDREQQAVLSRLAEEEKDNQQKLSANITAFSNYSATLKSQLSKVVEL
Sbjct: 181 QELSSEFEHLNQFLDREQQAVLSRLAEEEKDNQQKLSANITAFSNYSATLKSQLSKVVEL 240

Query: 241 SELSELELLSQIKIFYESENESSPSIFSIHLKRDGCSFPPQYSALQRIIKKFKVEIILDP 300
           SELSELELLSQIKIFYESENESSPSIFSIHLKRDGCSFPPQYSALQRIIKKFKVEIILDP
Sbjct: 241 SELSELELLSQIKIFYESENESSPSIFSIHLKRDGCSFPPQYSALQRIIKKFKVEIILDP 300

Query: 301 ETAHPNLIVSEDKKRVRFTKRKQKVPGFPKRFTVKPVVLGFPYFHSGRHFWEIEVGDKSE 360
           ETAHPNLIVSEDKKRVRFTKRKQKVPGFPKRFTVKPVVLGFPYFHSGRHFWEIEVGDKSE
Sbjct: 301 ETAHPNLIVSEDKKRVRFTKRKQKVPGFPKRFTVKPVVLGFPYFHSGRHFWEIEVGDKSE 360

Query: 361 WAIGICKDSLPTKARRPSSAQQECWRIELQDDGYHAPGAFPTPLLLEVKARAIGIFLDYE 420
           WAIGICKDSLPTKARRPSSAQQECWRIELQDDGYHAPGAFPTPLLLEVKARAIGIFLDYE
Sbjct: 361 WAIGICKDSLPTKARRPSSAQQECWRIELQDDGYHAPGAFPTPLLLEVKARAIGIFLDYE 420

Query: 421 MGEISFYNMAEKSHICTFTDTFTGPLRPYFYVGPDSQPLRICTGTVCE 468
           MGEISFYNMAEKSHICTFTDTFTGPLRPYFYVGPDSQPLRICTGTVCE
Sbjct: 421 MGEISFYNMAEKSHICTFTDTFTGPLRPYFYVGPDSQPLRICTGTVCE 468


>gi|22749269 ring finger protein 129 [Homo sapiens]
          Length = 471

 Score =  431 bits (1107), Expect = e-121
 Identities = 217/465 (46%), Positives = 301/465 (64%), Gaps = 2/465 (0%)

Query: 1   MAVAAALTGLQAEAKCSICLDYLSDPVTIECGHNFCRSCIQQSWLDLQELFPCPVCRHQC 60
           M    AL  LQ E+ C ICL+YL DPVTI CGHNFCRSC+  SW DL + FPCPVCR   
Sbjct: 1   MEFVTALVNLQEESSCPICLEYLKDPVTINCGHNFCRSCLSVSWKDLDDTFPCPVCRFCF 60

Query: 61  QEGHFRSNTQLGRMIEIAKLLQSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMVLCPLCT 120
               FR N QL  + EIAK LQ  +S +++Q+E  +CEKHNQ L++FC +DL +LC  C+
Sbjct: 61  PYKSFRRNPQLRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVKDLEILCTQCS 120

Query: 121 QPPDHQGHHVRPIEKAAIHYRKRFCSYIQPLKKQLADLQKLISTQSKKPLELREMVENQR 180
               HQ H++ PI+KAA ++R+     ++PL+  +  ++K+I  Q  K +EL++ VE +R
Sbjct: 121 FSTKHQKHYICPIKKAASYHREILEGSLEPLRNNIERVEKVIILQGSKSVELKKKVEYKR 180

Query: 181 QELSSEFEHLNQFLDREQQAVLSRLAEEEKDNQQKLSANITAFSNYSATLKSQLSKVVEL 240
           +E++SEFE +  FL  EQ+ +L ++ +EE +   KL+ N+   S+Y +TLK  L +V   
Sbjct: 181 EEINSEFEQIRLFLQNEQEMILRQIQDEEMNILAKLNENLVELSDYVSTLKHLLREVEGK 240

Query: 241 SELSELELLSQIK-IFYESENESSPSIFSIHLKRDGCSFPPQYSALQRIIKKFKVEIILD 299
           S  S LELL+Q K + ++ +N   P +FS  L + G S PPQYS L RIIK F+V++ILD
Sbjct: 241 SVQSNLELLTQAKSMHHKYQNLKCPELFSFRLTKYGFSLPPQYSGLDRIIKPFQVDVILD 300

Query: 300 PETAHPNLIVSEDKKRVRFTKRKQKVPGFPKRFTVKPVVLGFPYFHSGRHFWEIEVGDKS 359
             TAHP L+VSED+K VR+ ++K+ +   P+RF V P VLG   F SGRH+WE+EVG+K 
Sbjct: 301 LNTAHPQLLVSEDRKAVRYERKKRNICYDPRRFYVCPAVLGSQRFSSGRHYWEVEVGNKP 360

Query: 360 EWAIGICKDSLPTKARRPSSAQQECWRI-ELQDDGYHAPGAFPTPLLLEVKARAIGIFLD 418
           +W +G+C+D L    +   S     W I      GY A G   T LL  VK   IGIFLD
Sbjct: 361 KWILGVCQDCLLRNWQDQPSVLGGFWAIGRYMKSGYVASGPKTTQLLPVVKPSKIGIFLD 420

Query: 419 YEMGEISFYNMAEKSHICTFTDTFTGPLRPYFYVGPDSQPLRICT 463
           YE+G++SFYNM ++S + TF D FT  + PYFY G DS+PL+IC+
Sbjct: 421 YELGDLSFYNMNDRSILYTFNDCFTEAVWPYFYTGTDSEPLKICS 465


>gi|25777698 tripartite motif-containing 39 isoform 2 [Homo sapiens]
          Length = 488

 Score =  390 bits (1003), Expect = e-108
 Identities = 201/457 (43%), Positives = 291/457 (63%), Gaps = 8/457 (1%)

Query: 2   AVAAALTGLQAEAKCSICLDYLSDPVTIECGHNFCRSCIQQSWLDLQELFPCPVCRHQCQ 61
           + AAAL  LQ EA CS+CL+YL +PV IECGHNFC++CI + W DL+  FPCPVCR   +
Sbjct: 15  STAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSR 74

Query: 62  EGHFRSNTQLGRMIEIAKLLQSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMVLCPLCTQ 121
               R N QLG M+EIAK LQ+ K   RK  + +LC +H++ LS+FC ED   +C +C  
Sbjct: 75  YRSLRPNRQLGSMVEIAKQLQAVK---RKIRDESLCPQHHEALSLFCYEDQEAVCLICAI 131

Query: 122 PPDHQGHHVRPIEKAAIHYRKRFCSYIQPLKKQLADLQKLISTQSKKPLELREMVENQRQ 181
              H+ H V P++ A   Y+++    ++PL+++L ++ +  S++ KKP EL+ +VE++RQ
Sbjct: 132 SHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQ 191

Query: 182 ELSSEFEHLNQFLDREQQAVLSRLAEEEKDNQQKLSANITAFSNYSATLKSQLSKVVELS 241
           ++  EFE L++ LD EQQ +LSRL EEE+D  Q+L  N     +    L    ++V    
Sbjct: 192 QILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKC 251

Query: 242 ELSELELLSQIKIFYES-ENESSPSI--FSIHLKRDGCSFPPQYSALQRIIKKFKVEIIL 298
             S  E+L  +K   E  E   +  +   SI L+++  +FP QY AL++I+K+   ++ L
Sbjct: 252 LQSGFEMLKDVKSTLEKCEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTL 311

Query: 299 DPETAHPNLIVSEDKKRVRFTK-RKQKVPGFPKRFTVKPVVLGFPYFHSGRHFWEIEVGD 357
           DPETAHPNL++SED+K V+F + R + +P  P+RFT  P VL    F SGRH+WE+EVGD
Sbjct: 312 DPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGD 371

Query: 358 KSEWAIGICKDSLPTKARRPSSAQQECWRIELQDDGYHAPGAFP-TPLLLEVKARAIGIF 416
           K+ WA+G+C+DS+  K       +   WR+ L +   +A    P TPL ++VK + +GIF
Sbjct: 372 KTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIF 431

Query: 417 LDYEMGEISFYNMAEKSHICTFTDTFTGPLRPYFYVG 453
           LDYE G +SFYN+ ++SHI TFTDTFT  L P FY G
Sbjct: 432 LDYEAGTLSFYNVTDRSHIYTFTDTFTEKLWPLFYPG 468


>gi|25777696 tripartite motif-containing 39 isoform 1 [Homo sapiens]
          Length = 518

 Score =  379 bits (974), Expect = e-105
 Identities = 200/487 (41%), Positives = 289/487 (59%), Gaps = 38/487 (7%)

Query: 2   AVAAALTGLQAEAKCSICLDYLSDPVTIECGHNFCRSCIQQSWLDLQELFPCPVCRHQCQ 61
           + AAAL  LQ EA CS+CL+YL +PV IECGHNFC++CI + W DL+  FPCPVCR   +
Sbjct: 15  STAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSR 74

Query: 62  EGHFRSNTQLGRMIEIAKLLQSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMVLCPLCTQ 121
               R N QLG M+EIAK LQ+ K   RK  + +LC +H++ LS+FC ED   +C +C  
Sbjct: 75  YRSLRPNRQLGSMVEIAKQLQAVK---RKIRDESLCPQHHEALSLFCYEDQEAVCLICAI 131

Query: 122 PPDHQGHHVRPIEKAAIHYRKRFCSYIQPLKKQLADLQKLISTQSKKPLELREMVENQRQ 181
              H+ H V P++ A   Y+++    ++PL+++L ++ +  S++ KKP EL+ +VE++RQ
Sbjct: 132 SHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQ 191

Query: 182 ELSSEFEHLNQFLDREQQAVLSRLAEEEKDNQQKLSANITAFSNYSATLKSQLSKVVELS 241
           ++  EFE L++ LD EQQ +LSRL EEE+D  Q+L  N     +    L    ++V    
Sbjct: 192 QILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKC 251

Query: 242 ELSELELLSQIKIFYESE---------------------------------NESSPSIFS 268
             S  E+L  +K   E                                        +  S
Sbjct: 252 LQSGFEMLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCEKVKTMEVTSVS 311

Query: 269 IHLKRDGCSFPPQYSALQRIIKKFKVEIILDPETAHPNLIVSEDKKRVRFTK-RKQKVPG 327
           I L+++  +FP QY AL++I+K+   ++ LDPETAHPNL++SED+K V+F + R + +P 
Sbjct: 312 IELEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPD 371

Query: 328 FPKRFTVKPVVLGFPYFHSGRHFWEIEVGDKSEWAIGICKDSLPTKARRPSSAQQECWRI 387
            P+RFT  P VL    F SGRH+WE+EVGDK+ WA+G+C+DS+  K       +   WR+
Sbjct: 372 TPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRV 431

Query: 388 ELQDDGYHAPGAFP-TPLLLEVKARAIGIFLDYEMGEISFYNMAEKSHICTFTDTFTGPL 446
            L +   +A    P TPL ++VK + +GIFLDYE G +SFYN+ ++SHI TFTDTFT  L
Sbjct: 432 RLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFTEKL 491

Query: 447 RPYFYVG 453
            P FY G
Sbjct: 492 WPLFYPG 498


>gi|5730009 ret finger protein [Homo sapiens]
          Length = 513

 Score =  279 bits (714), Expect = 3e-75
 Identities = 163/492 (33%), Positives = 267/492 (54%), Gaps = 32/492 (6%)

Query: 1   MAVAAALTGLQAEAKCSICLDYLSDPVTIECGHNFCRSCIQQSWLDLQELFPCPVCRHQC 60
           MA  +    LQ E  C +CL Y ++P+ ++CGHN C +C+ + W   +    CP CR   
Sbjct: 1   MASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLARCWGTAETNVSCPQCRETF 60

Query: 61  QEGHFRSNTQLGRMIEIAKLLQSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMVLCPLCT 120
            + H R N  L  + ++ K L+ T+       E  +CEKH +PL ++C+ED M +C +C 
Sbjct: 61  PQRHMRPNRHLANVTQLVKQLR-TERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCD 119

Query: 121 QPPDHQGHHVRPIEKAAIHYRKRFCSYIQPLKKQLADLQKLISTQSKKP-LELREMVENQ 179
           +  +H+GH V P+E+A   ++++  + +  LK+ + DL+K    Q ++   EL  + + +
Sbjct: 120 RSREHRGHSVLPLEEAVEGFKEQIQNQLDHLKR-VKDLKKRRRAQGEQARAELLSLTQME 178

Query: 180 RQELSSEFEHLNQFLDREQQAVLSRLAEEEKDNQQKLSANITAFSNYSATLKSQLSKVVE 239
           R+++  EFE L   L   +  +L+RL E +      ++  IT FS   + L S ++++ E
Sbjct: 179 REKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQFSCNISHLSSLIAQLEE 238

Query: 240 LSELSELELLSQI-KIFYESENESSPSIF--------SIHLKRDGCSFPPQ--------- 281
             +    ELL  I      +E    P  +         IH+    C F  +         
Sbjct: 239 KQQQPTRELLQDIGDTLSRAERIRIPEPWITPPDLQEKIHIFAQKCLFLTESLKQFTEKM 298

Query: 282 YSALQRI-----IKKFKVEIILDPETAHPNLIVSEDKKRVRFTKRKQKVPGFPKRFTVKP 336
            S +++I      + + V++ LDP+TA+P+LI+S++ ++VR++  +Q +P  P+RF + P
Sbjct: 299 QSDMEKIQELREAQLYSVDVTLDPDTAYPSLILSDNLRQVRYSYLQQDLPDNPERFNLFP 358

Query: 337 VVLGFPYFHSGRHFWEIEVGDKSEWAIGICKDSLPTKARRPSSAQQECWRIEL-QDDGYH 395
            VLG P F +GRH+WE+EVGDK++W IG+C+DS+  K    S+ Q   W + L     Y 
Sbjct: 359 CVLGSPCFIAGRHYWEVEVGDKAKWTIGVCEDSVCRKGGVTSAPQNGFWAVSLWYGKEYW 418

Query: 396 APGAFPTPLLLEVKARAIGIFLDYEMGEISFYNMAEKSHICTFTD-TFTGPLRPYFYV-- 452
           A  +  T L L    + +GIFLDY+ GE+SFYN+ E+ H  TF+  TF GP+RPYF +  
Sbjct: 419 ALTSPMTALPLRTPLQRVGIFLDYDAGEVSFYNVTERCHTFTFSHATFCGPVRPYFSLSY 478

Query: 453 --GPDSQPLRIC 462
             G  + PL IC
Sbjct: 479 SGGKSAAPLIIC 490


>gi|21630277 tripartite motif-containing 11 [Homo sapiens]
          Length = 468

 Score =  278 bits (712), Expect = 6e-75
 Identities = 160/467 (34%), Positives = 247/467 (52%), Gaps = 17/467 (3%)

Query: 1   MAVAAALTGLQAEAKCSICLDYLSDPVTIECGHNFCRSCIQQSWLDLQELFPCPVCRHQC 60
           MA     T LQ EA C+ICLDY +DPV  +CGHNFCR CI++ W   +  + CP CR   
Sbjct: 1   MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS 60

Query: 61  QEGHFRSNTQLGRMIEIAKLLQSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMVLCPLCT 120
            + + R N  L +M E+A+ L       +      +C  H +PL+ FC ++L +LC  C 
Sbjct: 61  PQRNLRPNRPLAKMAEMARRLHPPSPVPQG-----VCPAHREPLAAFCGDELRLLCAACE 115

Query: 121 QPPDHQGHHVRPIEKAAIHYRKRFCSYIQPLKKQLADLQKLISTQSKKPLELREMVENQR 180
           +  +H  H VRP++ AA   + +    ++ L+KQ+ D     +   +  +  ++MVE+QR
Sbjct: 116 RSGEHWAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMVESQR 175

Query: 181 QELSSEFEHLNQFLDREQQAVLSRLAEEEKDNQQKLSANITAFSNYSATLKSQLSKVVEL 240
           Q +  EFE L + L  E+Q +L RL EEE +   +L          SA L   ++++   
Sbjct: 176 QNVLGEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAELEGR 235

Query: 241 SELSELELLSQIKIFYESENE---SSPSIFSIHLKRDGCSFPPQYSALQRIIKKFKVEII 297
            +L  L LL  IK       +     P +  + L R  C  P     L   +++F+ ++ 
Sbjct: 236 CQLPALGLLQDIKDALRRVQDVKLQPPEVVPMEL-RTVCRVP----GLVETLRRFRGDVT 290

Query: 298 LDPETAHPNLIVSEDKKRVRFTKRKQKVPGFPKRFTVKPVVLGFPYFHSGRHFWEIEVGD 357
           LDP+TA+P LI+SED++ V+    +Q +P  P+RF   P VLG   F SGRH+WE+EVGD
Sbjct: 291 LDPDTANPELILSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQERFTSGRHYWEVEVGD 350

Query: 358 KSEWAIGICKDSLPTKARRPSSAQQECWRIELQDDGYHAPGAFPTPLLLEVKARAIGIFL 417
           ++ WA+G+C++++  K +   SA    W +      Y++      P  L    R +GIFL
Sbjct: 351 RTSWALGVCRENVNRKEKGELSAGNGFWILVFLGSYYNSSERALAP--LRDPPRRVGIFL 408

Query: 418 DYEMGEISFYNMAEKSHICTFTD-TFTGPLRPYFY-VGPDSQPLRIC 462
           DYE G +SFY+  + S +  F +  F+G LRP F  +     P+ IC
Sbjct: 409 DYEAGHLSFYSATDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTIC 455


>gi|112421127 tripartite motif-containing 58 [Homo sapiens]
          Length = 486

 Score =  276 bits (707), Expect = 2e-74
 Identities = 160/474 (33%), Positives = 262/474 (55%), Gaps = 19/474 (4%)

Query: 1   MAVAAALTGLQAEAKCSICLDYLSDPVTIECGHNFCRSCIQQSWLDLQE-----LFPCPV 55
           MA A     L+ +A+C +CLD+L +PV+++CGH+FC  CI + + +  +     ++ CP 
Sbjct: 1   MAWAPPGERLREDARCPVCLDFLQEPVSVDCGHSFCLRCISE-FCEKSDGAQGGVYACPQ 59

Query: 56  CRHQCQEGHFRSNTQLGRMIEIAKLLQSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMVL 115
           CR   +   FR N QL  ++E  + L        ++     C +H + LS FC+ED   L
Sbjct: 60  CRGPFRPSGFRPNRQLAGLVESVRRLGLGAGPGARR-----CARHGEDLSRFCEEDEAAL 114

Query: 116 CPLCTQPPDHQGHHVRPIEKAAIHYRKRFCSYIQPLKKQLADLQKLISTQSKKPLELREM 175
           C +C   P+H+ H   P+++AA  Y+ +    ++ ++K+L D     +   KK +  +E 
Sbjct: 115 CWVCDAGPEHRTHRTAPLQEAAGSYQVKLQMALELMRKELEDALTQEANVGKKTVIWKEK 174

Query: 176 VENQRQELSSEFEHLNQFLDREQQAVLSRLAEEEKDNQQKLSANITAFSNYSATLKSQLS 235
           VE QRQ    EFE    FL +E+Q  L RL  EE+   Q+L  + +     S  LK    
Sbjct: 175 VEMQRQRFRLEFEKHRGFLAQEEQRQLRRLEAEERATLQRLRESKSRLVQQSKALKELAD 234

Query: 236 KVVELSELSELELLSQIK-IFYESENESSPSIFSIHLK-RDGCSFPPQYSALQRIIKKFK 293
           ++ E  +   L LL  ++ +   S+  +     +I ++ +  C  P +    + +++KF+
Sbjct: 235 ELQERCQRPALGLLEGVRGVLSRSKAVTRLEAENIPMELKTACCIPGR----RELLRKFQ 290

Query: 294 VEIILDPETAHPNLIVSEDKKRVRFTKRKQKVPGFPKRFTVKPVVLGFPYFHSGRHFWEI 353
           V++ LDP TAHP+L+++ D + V+  +  + VP  P+RF   P +LG   F SGRH+WE+
Sbjct: 291 VDVKLDPATAHPSLLLTADLRSVQDGEPWRDVPNNPERFDTWPCILGLQSFSSGRHYWEV 350

Query: 354 EVGDKSEWAIGICKDSLPTKARRPSSAQQECWRIELQDDGYHAPGAFPTPLLLEVKA-RA 412
            VG+ +EW +G+C+D+LP K     S +   W + L     +   A P+  LL++++ R 
Sbjct: 351 LVGEGAEWGLGVCQDTLPRKGETTPSPENGVWALWLLKGNEYMVLASPSVPLLQLESPRC 410

Query: 413 IGIFLDYEMGEISFYNMAEKSHICTFTDTFTGPLRPYFYVGPDSQPLRICTGTV 466
           IGIFLDYE GEISFYN+ + S+I TF   F+G LRPYF++  D+ PL +   T+
Sbjct: 411 IGIFLDYEAGEISFYNVTDGSYIYTFNQLFSGLLRPYFFI-CDATPLILPPTTI 463


>gi|37622899 ring finger protein 137 [Homo sapiens]
          Length = 485

 Score =  270 bits (691), Expect = 2e-72
 Identities = 168/488 (34%), Positives = 258/488 (52%), Gaps = 33/488 (6%)

Query: 1   MAVAAALTGLQAEAKCSICLDYLSDPVTIECGHNFCRSCIQQSWLDLQEL----FPCPVC 56
           M   A +  +  E  C IC+ +L +P++I+CGH+FC SC+   W    E     + CP+C
Sbjct: 1   MDPTALVEAIVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLC 60

Query: 57  RHQCQEGHFRSNTQLGRMIEIAKLLQSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMVLC 116
           R   Q  + R N QL  ++E  +LL+       K +   LCE+H + L +FCKED++++C
Sbjct: 61  RAPVQPRNLRPNWQLANVVEKVRLLRLHPGMGLKGD---LCERHGEKLKMFCKEDVLIMC 117

Query: 117 PLCTQPPDHQGHHVRPIEKAAIHYRKRFCSYIQPLKKQLADLQKLISTQSKKPLELREMV 176
             C+Q P+H+ H V P+E  A  Y+      ++ LKK+  +  KL   + K+    +  V
Sbjct: 118 EACSQSPEHEAHSVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKIQV 177

Query: 177 ENQRQELSSEFEHLNQFLDREQQ----------AVLSRLAEEEKDNQQKLSANITAFSNY 226
           E ++Q +  EFE   + L+++Q           A L+ L  E  +  QKL  N +     
Sbjct: 178 ETRKQSIVWEFEKYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQ 237

Query: 227 SATLKSQLSKVVELSELSELELLSQIK-IFYESENES--SPSIFSIHLKRDGCSFPPQYS 283
           S  L   ++++ E S+     +L  I+ +   S++ S   P   S+ LK D C    +  
Sbjct: 238 SQVLWRMIAELKERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLELKTD-C----RVL 292

Query: 284 ALQRIIKKFKVEIILDPETAHPNLIVSEDKKRVRFTKRKQKVPGFPKRFTVKPVVLGFPY 343
            L+ I+K +  ++ LDP+TA+  LIVSED+KRV +    QK+P  P+RF    +VLG   
Sbjct: 293 GLREILKTYAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLPDNPERFYRYNIVLGSQC 352

Query: 344 FHSGRHFWEIEVGDKSEWAIGICKDSLPTKARRPSSAQQECWRIELQDDGYHAPGAFPTP 403
             SGRH+WE+EVGD+SEW +G+CK ++  K     S     W I L+    +  G    P
Sbjct: 353 ISSGRHYWEVEVGDRSEWGLGVCKQNVDRKEVVYLSPHYGFWVIRLRKGNEYRAGTDEYP 412

Query: 404 LL-LEVKARAIGIFLDYEMGEISFYNMAE-KSHICTFTD-TFTGPLRPYF----YVGP-D 455
           +L L V  R +GIF+DYE  +ISFYN+ +  SHI TF    F G L PYF     +G  +
Sbjct: 413 ILSLPVPPRRVGIFVDYEAHDISFYNVTDCGSHIFTFPRYPFPGRLLPYFSPCYSIGTNN 472

Query: 456 SQPLRICT 463
           + PL IC+
Sbjct: 473 TAPLAICS 480


>gi|15208660 tripartite motif protein 21 [Homo sapiens]
          Length = 475

 Score =  269 bits (688), Expect = 4e-72
 Identities = 166/473 (35%), Positives = 256/473 (54%), Gaps = 21/473 (4%)

Query: 1   MAVAAALTGLQAEAKCSICLDYLSDPVTIECGHNFCRSCIQQSWLDLQELFPCPVCRHQC 60
           MA AA LT +  E  C ICLD   +PV+IECGH+FC+ CI Q       +  CPVCR + 
Sbjct: 1   MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSV--CPVCRQRF 58

Query: 61  QEGHFRSNTQLGRMIEIAKLLQSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMVLCPLCT 120
              + R N QL  M+     L+      R+  +   C  H + L +FC++D   LC +C 
Sbjct: 59  LLKNLRPNRQLANMVNN---LKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCA 115

Query: 121 QPPDHQGHHVRPIEKAAIHYRKRFCSYIQPLKKQLADLQKLISTQSKKPLELREMVENQR 180
           Q   H+ H + P+E+AA  Y+++    +  L+++    +KL    + K  + ++ VE Q+
Sbjct: 116 QSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQK 175

Query: 181 QELSSEFEHLNQFLDREQQAVLSRLAEEEKDNQQKLSANITAFSNYSATLKSQLSKVVEL 240
             + +EF     FL  E+Q  L  L ++E++  + L       +  S  L+  +S++   
Sbjct: 176 SRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRR 235

Query: 241 SELSELELLSQIKIFYE---SENESSPSIFSIHLKRDGCSFPPQYSALQRIIKKFKVEII 297
              S LELL ++ I  E   S N     I S  L R  C  P     L+++++   V I 
Sbjct: 236 CHSSALELLQEVIIVLERSESWNLKDLDITSPEL-RSVCHVP----GLKKMLRTCAVHIT 290

Query: 298 LDPETAHPNLIVSEDKKRVRFTKRKQKVPGFPKRFTVKPVVLGFPYFHSGRHFWEIEVGD 357
           LDP+TA+P LI+SED+++VR    +Q +PG  +RF   P+VLG  +FHSG+H+WE++V  
Sbjct: 291 LDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTG 350

Query: 358 KSEWAIGICKDSLPTKARRPSSAQQECWRIELQDDGYHAPGAFP-TPLLLEVKARAIGIF 416
           K  W +G+C+DS+  K     S++   W I L +   +  G +P TPL L+V    +GIF
Sbjct: 351 KEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIF 410

Query: 417 LDYEMGEISFYNMAEK-SHICTFTD-TFTGPLRPYFYV-----GPDSQPLRIC 462
           LDYE G +SFYN+ +  S I +F++  FTGPLRP+F       G ++ PL +C
Sbjct: 411 LDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLC 463


>gi|15011941 tripartite motif protein TRIM4 isoform beta [Homo
           sapiens]
          Length = 474

 Score =  250 bits (638), Expect = 2e-66
 Identities = 149/467 (31%), Positives = 238/467 (50%), Gaps = 33/467 (7%)

Query: 10  LQAEAKCSICLDYLSDPVTIECGHNFCRSCIQQSWLDLQELFPCPVCRHQCQEGHFRSNT 69
           +Q E  C ICLDY  DPV+IECGHNFCR C+ ++W      FPCP CRH       R N 
Sbjct: 6   IQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNWAPGGGPFPCPECRHPSAPAALRPNW 65

Query: 70  QLGRMIEIAKLLQSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMVLCPLCTQPPDHQGHH 129
            L R+ E       T+  +       LC +H +PL +FC++D   +C +C +  +HQ H 
Sbjct: 66  ALARLTE------KTQRRRLGPVPPGLCGRHWEPLRLFCEDDQRPVCLVCRESQEHQTHA 119

Query: 130 VRPIEKAAIHYRKRFCSYIQPLKKQLADLQKLISTQSKKPLELREMVENQRQELSSEFEH 189
           + PI++A   YR++     + L  ++  +  L   + K   + ++ +++QR  +S+EF  
Sbjct: 120 MAPIDEAFESYREKLLKSQRNLVAKMKKVMHLQDVEVKNATQWKDKIKSQRMRISTEFSK 179

Query: 190 LNQFLDREQQAVLSRLAEEEKDNQQKLSANITAFSNYSATLKSQLSKVVELSELSELELL 249
           L+ FL  E+   L RL +EE++ ++KL+ N    +   A+LK  + +V E S+   LELL
Sbjct: 180 LHNFLVEEEDLFLQRLNKEEEETKKKLNENTLKLNQTIASLKKLILEVGEKSQAPTLELL 239

Query: 250 SQIK-IFYESE-NESSPSIFSIHLKRDGCSFPPQYSALQRIIKKFKVEIILDPETAHPNL 307
              K +   SE  + + S+ ++ +K   C  P     ++ ++K+F+V + L  +TAHP L
Sbjct: 240 QNPKEVLTRSEIQDVNYSLEAVKVK-TVCQIP----LMKEMLKRFQVAVNLAEDTAHPKL 294

Query: 308 IVSEDKKRVRFTK------------------RKQKVPGFPKRFTVKPVVLGFPYFHSGRH 349
           + S++ + V+ T                   R  +   F +RF   P VLG   F SG+H
Sbjct: 295 VFSQEGRYVKNTASASSWPVFSSAWNYFAGWRNPQKTAFVERFQHLPCVLGKNVFTSGKH 354

Query: 350 FWEIEVGDKSEWAIGICK-DSLPTKARRPSSAQQECWRIELQDDGYHAPGAFP-TPLLLE 407
           +WE+E  D  E A+G+C+ D +    R   S     W I     GY     FP TP   E
Sbjct: 355 YWEVESRDSLEVAVGVCREDVMGITDRSKMSPDVGIWAIYWSAAGYWPLIGFPGTPTQQE 414

Query: 408 VKARAIGIFLDYEMGEISFYNMAEKSHICTFTDTFTGPLRPYFYVGP 454
                +G++LD   G +SFY+  +  H+ TF+ +    LRP+F++ P
Sbjct: 415 PALHRVGVYLDRGTGNVSFYSAVDGVHLHTFSCSSVSRLRPFFWLSP 461


>gi|68160933 tripartite motif-containing 17 isoform 1 [Homo sapiens]
          Length = 477

 Score =  246 bits (628), Expect = 3e-65
 Identities = 149/476 (31%), Positives = 253/476 (53%), Gaps = 31/476 (6%)

Query: 10  LQAEAKCSICLDYLSDPVTIECGHNFCRSCIQQSWLDLQEL---------FPCPVCRHQC 60
           LQ EA CSICLDY +DPV   CGHNFCR+CIQ SW   +           FPCP CR   
Sbjct: 10  LQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSFPCPECREMS 69

Query: 61  QEGHFRSNTQLGRMIEIAKLLQSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMVLCPLCT 120
            + +   N  L ++ E+A+         +KQ+   LC++H++PL +FC++D   +C +C 
Sbjct: 70  PQRNLLPNRLLTKVAEMAQ----QHPGLQKQD---LCQEHHEPLKLFCQKDQSPICVVCR 122

Query: 121 QPPDHQGHHVRPIEKAAIHYRKRFCSYIQPLKKQLADLQKLISTQSKKPLELREMVENQR 180
           +  +H+ H V P E+A   Y+ +    ++ L++Q+     L + + +   E +  V+ +R
Sbjct: 123 ESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVKERR 182

Query: 181 QELSSEFEHLNQFLDREQQAVLSRLAEEEKDNQQKLSANITAFSNYSATLKSQLSKVVEL 240
           + +  EFE +N +L  E+Q +L  L  EE++   +L  ++        +L+  L ++ E 
Sbjct: 183 ERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLLQLEER 242

Query: 241 SELSELELLSQIKIFYESENESS---PSIFSIHLKRDGCSFPPQYSALQRIIKKFKVEII 297
           S    L++L  +K     +N  S   P +      R  C  P Q      +++ F  +++
Sbjct: 243 STQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQI----EVLRGFLEDVV 298

Query: 298 LDPETAHPNLIVSEDKKRVRFTKRKQKVPGF--PKRFTVKPVVLGFPYFHSGRHFWEI-- 353
            D  +A+P L++ E ++R R+     +  GF    RF   P  +G   F SGRH+WE+  
Sbjct: 299 PDATSAYPYLLLYESRQR-RYLGSSPEGSGFCSKDRFVAYPCAVGQTAFSSGRHYWEVGM 357

Query: 354 EVGDKSEWAIGICKDSLPTKARRPSSAQQECWRIEL-QDDGYHAPGAFPTPLLLEVKARA 412
            +   + WA+G+C+D++  K R P   +   W ++L +   Y +  +  TP++L      
Sbjct: 358 NITGDALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKYLSTFSALTPVMLMEPPSH 417

Query: 413 IGIFLDYEMGEISFYNMAEKSHICTFTD-TFTGPLRPYFYVG-PDSQPLRICTGTV 466
           +GIFLD+E GE+SFY++++ SH+ T++  TF GPL+P+F +G P S  + I T T+
Sbjct: 418 MGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFFCLGAPKSGQMVISTVTM 473


>gi|7705825 tripartite motif-containing 17 isoform 1 [Homo sapiens]
          Length = 477

 Score =  246 bits (628), Expect = 3e-65
 Identities = 149/476 (31%), Positives = 253/476 (53%), Gaps = 31/476 (6%)

Query: 10  LQAEAKCSICLDYLSDPVTIECGHNFCRSCIQQSWLDLQEL---------FPCPVCRHQC 60
           LQ EA CSICLDY +DPV   CGHNFCR+CIQ SW   +           FPCP CR   
Sbjct: 10  LQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSFPCPECREMS 69

Query: 61  QEGHFRSNTQLGRMIEIAKLLQSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMVLCPLCT 120
            + +   N  L ++ E+A+         +KQ+   LC++H++PL +FC++D   +C +C 
Sbjct: 70  PQRNLLPNRLLTKVAEMAQ----QHPGLQKQD---LCQEHHEPLKLFCQKDQSPICVVCR 122

Query: 121 QPPDHQGHHVRPIEKAAIHYRKRFCSYIQPLKKQLADLQKLISTQSKKPLELREMVENQR 180
           +  +H+ H V P E+A   Y+ +    ++ L++Q+     L + + +   E +  V+ +R
Sbjct: 123 ESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVKERR 182

Query: 181 QELSSEFEHLNQFLDREQQAVLSRLAEEEKDNQQKLSANITAFSNYSATLKSQLSKVVEL 240
           + +  EFE +N +L  E+Q +L  L  EE++   +L  ++        +L+  L ++ E 
Sbjct: 183 ERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLLQLEER 242

Query: 241 SELSELELLSQIKIFYESENESS---PSIFSIHLKRDGCSFPPQYSALQRIIKKFKVEII 297
           S    L++L  +K     +N  S   P +      R  C  P Q      +++ F  +++
Sbjct: 243 STQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQI----EVLRGFLEDVV 298

Query: 298 LDPETAHPNLIVSEDKKRVRFTKRKQKVPGF--PKRFTVKPVVLGFPYFHSGRHFWEI-- 353
            D  +A+P L++ E ++R R+     +  GF    RF   P  +G   F SGRH+WE+  
Sbjct: 299 PDATSAYPYLLLYESRQR-RYLGSSPEGSGFCSKDRFVAYPCAVGQTAFSSGRHYWEVGM 357

Query: 354 EVGDKSEWAIGICKDSLPTKARRPSSAQQECWRIEL-QDDGYHAPGAFPTPLLLEVKARA 412
            +   + WA+G+C+D++  K R P   +   W ++L +   Y +  +  TP++L      
Sbjct: 358 NITGDALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKYLSTFSALTPVMLMEPPSH 417

Query: 413 IGIFLDYEMGEISFYNMAEKSHICTFTD-TFTGPLRPYFYVG-PDSQPLRICTGTV 466
           +GIFLD+E GE+SFY++++ SH+ T++  TF GPL+P+F +G P S  + I T T+
Sbjct: 418 MGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFFCLGAPKSGQMVISTVTM 473


>gi|157426898 tripartite motif-containing 10 isoform 1 [Homo
           sapiens]
          Length = 481

 Score =  242 bits (617), Expect = 6e-64
 Identities = 147/470 (31%), Positives = 243/470 (51%), Gaps = 22/470 (4%)

Query: 1   MAVAAALTGLQAEAKCSICLDYLSDPVTIECGHNFCRSCIQQ----SWLDLQELFPCPVC 56
           MA AA++T L  E  C IC   L +PVTI+CGHNFCR+C+ +       DL+E   CP+C
Sbjct: 1   MASAASVTSLADEVNCPICQGTLREPVTIDCGHNFCRACLTRYCEIPGPDLEESPTCPLC 60

Query: 57  RHQCQEGHFRSNTQLGRMIEIAKLLQSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMVLC 116
           +   + G FR N QL  ++E  + LQ   +    +E+  +C++H + +  FC++D M LC
Sbjct: 61  KEPFRPGSFRPNWQLANVVENIERLQLVSTLGLGEED--VCQEHGEKIYFFCEDDEMQLC 118

Query: 117 PLCTQPPDHQGHHVRPIEKAAIHYRKRFCSYIQPLKKQLADLQKLISTQSKKPLELREMV 176
            +C +  +H  H +R +E AA  YR++    ++ L+K+  ++Q++ S ++K+   L   V
Sbjct: 119 VVCREAGEHATHTMRFLEDAAAPYREQIHKCLKCLRKEREEIQEIQSRENKRMQVLLTQV 178

Query: 177 ENQRQELSSEFEHLNQFLDREQQAVLSRLAEEEKDNQQKLSANITAFSNYSATLKSQLSK 236
             +RQ++ SEF HL +FL+ +Q  +L++L  ++ D  ++        +       + + +
Sbjct: 179 STKRQQVISEFAHLRKFLEEQQSILLAQLESQDGDILRQRDEFDLLVAGEICRFSALIEE 238

Query: 237 VVELSELSELELLSQIK---IFYESENESSPSIFSIHLKRDGCSFPPQYSALQRIIKKF- 292
           + E +E    ELL+ I+   I  E+     P   S  L +    FP Q   LQR +K F 
Sbjct: 239 LEEKNERPARELLTDIRSTLIRCETRKCRKPVAVSPELGQRIRDFPQQALPLQREMKMFL 298

Query: 293 ----------KVEIILDPETAHPNLIVSEDKKRVRFTKRKQKVPGFPKRFTVKPVVLGFP 342
                        I LDP+T+HP L++SED +R +F+ + Q  P  P+RF     VL   
Sbjct: 299 EKLCFELDYEPAHISLDPQTSHPKLLLSEDHQRAQFSYKWQNSPDNPQRFDRATCVLAHT 358

Query: 343 YFHSGRHFW--EIEVGDKSEWAIGICKDSLPTKARRPSSAQQECWRIELQDDGYHAPGAF 400
               GRH W   I++       +G+  + +  K       ++  W + L      A G+F
Sbjct: 359 GITGGRHTWVVSIDLAHGGSCTVGVVSEDVQRKGELRLRPEEGVWAVRLAWGFVSALGSF 418

Query: 401 PTPLLLEVKARAIGIFLDYEMGEISFYNMAEKSHICTFTDTFTGPLRPYF 450
           PT L L+ + R + + LDYE+G ++F N   +  I TFT +FT  + P+F
Sbjct: 419 PTRLTLKEQPRQVRVSLDYEVGWVTFTNAVTREPIYTFTASFTRKVIPFF 468


>gi|14670266 tripartite motif protein TRIM4 isoform alpha [Homo
           sapiens]
          Length = 500

 Score =  241 bits (614), Expect = 1e-63
 Identities = 156/493 (31%), Positives = 247/493 (50%), Gaps = 59/493 (11%)

Query: 10  LQAEAKCSICLDYLSDPVTIECGHNFCRSCIQQSWLDLQELFPCPVCRHQCQEGHFRSNT 69
           +Q E  C ICLDY  DPV+IECGHNFCR C+ ++W      FPCP CRH       R N 
Sbjct: 6   IQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNWAPGGGPFPCPECRHPSAPAALRPNW 65

Query: 70  QLGRMIEIAKLLQSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMVLCPLCTQPPDHQGHH 129
            L      A+L + T+  +       LC +H +PL +FC++D   +C +C +  +HQ H 
Sbjct: 66  AL------ARLTEKTQRRRLGPVPPGLCGRHWEPLRLFCEDDQRPVCLVCRESQEHQTHA 119

Query: 130 VRPIEKAAIHYRK-RFCSYIQPLKKQLADL--------QKLISTQ------SKKPLELRE 174
           + PI++A   YR   F  ++   K++L  L        +KL+ +Q       KK + L++
Sbjct: 120 MAPIDEAFESYRTGNFDIHVDEWKRRLIRLLLYHSKQEEKLLKSQRNLVAKMKKVMHLQD 179

Query: 175 M-----------VENQRQELSSEFEHLNQFLDREQQAVLSRLAEEEKDNQQKLSANITAF 223
           +           +++QR  +S+EF  L+ FL  E+   L RL +EE++ ++KL+ N    
Sbjct: 180 VEVKNATQWKDKIKSQRMRISTEFSKLHNFLVEEEDLFLQRLNKEEEETKKKLNENTLKL 239

Query: 224 SNYSATLKSQLSKVVELSELSELELLSQIK-IFYESE-NESSPSIFSIHLKRDGCSFPPQ 281
           +   A+LK  + +V E S+   LELL   K +   SE  + + S+ ++ +K   C  P  
Sbjct: 240 NQTIASLKKLILEVGEKSQAPTLELLQNPKEVLTRSEIQDVNYSLEAVKVK-TVCQIP-- 296

Query: 282 YSALQRIIKKFKVEIILDPETAHPNLIVSEDKKRVRFTK------------------RKQ 323
              ++ ++K+F+V + L  +TAHP L+ S++ + V+ T                   R  
Sbjct: 297 --LMKEMLKRFQVAVNLAEDTAHPKLVFSQEGRYVKNTASASSWPVFSSAWNYFAGWRNP 354

Query: 324 KVPGFPKRFTVKPVVLGFPYFHSGRHFWEIEVGDKSEWAIGICK-DSLPTKARRPSSAQQ 382
           +   F +RF   P VLG   F SG+H+WE+E  D  E A+G+C+ D +    R   S   
Sbjct: 355 QKTAFVERFQHLPCVLGKNVFTSGKHYWEVESRDSLEVAVGVCREDVMGITDRSKMSPDV 414

Query: 383 ECWRIELQDDGYHAPGAFP-TPLLLEVKARAIGIFLDYEMGEISFYNMAEKSHICTFTDT 441
             W I     GY     FP TP   E     +G++LD   G +SFY+  +  H+ TF+ +
Sbjct: 415 GIWAIYWSAAGYWPLIGFPGTPTQQEPALHRVGVYLDRGTGNVSFYSAVDGVHLHTFSCS 474

Query: 442 FTGPLRPYFYVGP 454
               LRP+F++ P
Sbjct: 475 SVSRLRPFFWLSP 487


>gi|44680122 tripartite motif-containing 7 isoform 1 [Homo sapiens]
          Length = 511

 Score =  229 bits (584), Expect = 4e-60
 Identities = 145/496 (29%), Positives = 236/496 (47%), Gaps = 36/496 (7%)

Query: 2   AVAAALTG-LQAEAKCSICLDYLSDPVTIECGHNFCRSCIQQSWLDLQE----------- 49
           A A AL   LQ EA CSICL+   +PV++ECGH+FCR+CI + W                
Sbjct: 14  AEALALAAELQGEATCSICLELFREPVSVECGHSFCRACIGRCWERPGAGSVGAATRAPP 73

Query: 50  -LFPCPVCRHQCQEGHFRSNTQLGRMIEIAKLL--------QSTKSNKRKQEETTLCEKH 100
              PCP CR   +    R N QL  +  + +          +        +     C +H
Sbjct: 74  FPLPCPQCREPARPSQLRPNRQLAAVATLLRRFSLPAAAPGEHGSQAAAARAAAARCGQH 133

Query: 101 NQPLSVFCKEDLMVLCPLCTQPPDHQGHHVRPIEKAAIHYRKRFCSYIQPLKKQLADLQK 160
            +P  ++C++D   +C +C +  +H+ H V P+++A    ++   S ++ LKK+L D + 
Sbjct: 134 GEPFKLYCQDDGRAICVVCDRAREHREHAVLPLDEAVQEAKELLESRLRVLKKELEDCEV 193

Query: 161 LISTQSKKPLELREMVENQRQELSSEFEHLNQFLDREQQAVLSRLAEEEKDNQQKLSANI 220
             ST+ K+  EL + +  +++++ +EF+ L  FL  ++  +L RL E  ++  QK + N+
Sbjct: 194 FRSTEKKESKELLKQMAAEQEKVGAEFQALRAFLVEQEGRLLGRLEELSREVAQKQNENL 253

Query: 221 TAFSNYSATLKSQLSKVVELSELSELELLSQIKIFYESENE---SSPSIFSIHLKRDGCS 277
                    L    S++ E ++  +L+ L + K      +      P+  S  +K    +
Sbjct: 254 AQLGVEITQLSKLSSQIQETAQKPDLDFLQEFKSTLSRCSNVPGPKPTTVSSEMKNKVWN 313

Query: 278 FPPQYSALQRIIKKFK------------VEIILDPETAHPNLIVSEDKKRVRFTKRKQKV 325
              +   L+ ++KKFK            VE+ LDP+TA+P LI+S D K VR  +R Q +
Sbjct: 314 VSLKTFVLKGMLKKFKEDLRGELEKEEKVELTLDPDTANPRLILSLDLKGVRLGERAQDL 373

Query: 326 PGFPKRFTVKPVVLGFPYFHSGRHFWEIEVGDKSEWAIGICKDSLPTKARRPSSAQQECW 385
           P  P RF     VL    F SGRH WE+EVG K  WA G+ ++S+  K   P + ++  W
Sbjct: 374 PNHPCRFDTNTRVLASCGFSSGRHHWEVEVGSKDGWAFGVARESVRRKGLTPFTPEEGVW 433

Query: 386 RIELQDDGYHAPGAFPTPLLLEVKARAIGIFLDYEMGEISFYNMAEKSHICTFTDTFTGP 445
            ++L    Y A  +     L       + + LD E+G +SFY + +  H+ TF   F   
Sbjct: 434 ALQLNGGQYWAVTSPERSPLSCGHLSRVRVALDLEVGAVSFYAVEDMRHLYTFRVNFQER 493

Query: 446 LRPYFYVGPDSQPLRI 461
           + P F V      LRI
Sbjct: 494 VFPLFSVCSTGTYLRI 509


>gi|5454014 tripartite motif-containing 38 [Homo sapiens]
          Length = 465

 Score =  228 bits (582), Expect = 7e-60
 Identities = 147/466 (31%), Positives = 243/466 (52%), Gaps = 28/466 (6%)

Query: 1   MAVAAALTGLQAEAKCSICLDYLSDPVTIECGHNFCRSCIQQSWLD------LQELFPCP 54
           MA   +   +  EA CSICL  +++PV+I CGH++C  CI   + +       QE F CP
Sbjct: 1   MASTTSTKKMMEEATCSICLSLMTNPVSINCGHSYCHLCITDFFKNPSQKQLRQETFCCP 60

Query: 55  VCRHQCQEGHFRSNTQLGRMIEIAKLLQSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMV 114
            CR        R N QLG +IE  K          + ++   CE+H +   +FC+++  +
Sbjct: 61  QCRAPFHMDSLRPNKQLGSLIEALK----------ETDQEMSCEEHGEQFHLFCEDEGQL 110

Query: 115 LCPLCTQPPDHQGHHVRPIEKAAIHYRKRFCSYIQPLKKQLAD--LQKLISTQSKKPLEL 172
           +C  C + P H+GH    +E     Y+++    +  LK QL D   ++ +ST + +  + 
Sbjct: 111 ICWRCERAPQHKGHTTALVEDVCQGYKEKLQKAVTKLK-QLEDRCTEQKLST-AMRITKW 168

Query: 173 REMVENQRQELSSEFEHLNQFLDREQQAVLSRLAEEEKDNQQKLSANITAFSNYSATLKS 232
           +E V+ QRQ++ S+F++L  FL  E+++ L RL +EE+    +L          S  LKS
Sbjct: 169 KEKVQIQRQKIRSDFKNLQCFLHEEEKSYLWRLEKEEQQTLSRLRDYEAGLGLKSNELKS 228

Query: 233 QLSKVVELSELSELELLSQIKIF----YESENESSPSIFSIHLKRDGCSFPPQYSALQRI 288
            + ++ E  + S  +LL  +       +  + E+S ++ S+ L    C+    Y  ++++
Sbjct: 229 HILELEEKCQGSAQKLLQNVNDTLSRSWAVKLETSEAV-SLEL-HTMCNVSKLYFDVKKM 286

Query: 289 IKKFKVEIILDPETAHPNLIVSEDKKRVRFTKRKQKVPGFPKRFTVKPVVLGFPYFHSGR 348
           ++  +V + LDP+TAH  LI+SED+++V     ++      +RFT  P VLG   F SGR
Sbjct: 287 LRSHQVSVTLDPDTAHHELILSEDRRQVTRGYTQENQDTSSRRFTAFPCVLGCEGFTSGR 346

Query: 349 HFWEIEVGDKSEWAIGICKDSLPTKARRPSSAQQECWRIEL-QDDGYHAPGAFPTPLLLE 407
            ++E++VG+ + W +G+C +++          Q   W + L +  GY A  + PT L L 
Sbjct: 347 RYFEVDVGEGTGWDLGVCMENVQRGTGMKQEPQSGFWTLRLCKKKGYVALTSPPTSLHLH 406

Query: 408 VKARAIGIFLDYEMGEISFYNMAEKSHICTFTD-TFTGPLRPYFYV 452
            +   +GIFLDYE G +SFYN     HI TF   +F+  LRPYF V
Sbjct: 407 EQPLLVGIFLDYEAGVVSFYNGNTGCHIFTFPKASFSDTLRPYFQV 452


>gi|31542779 tripartite motif family-like 1 [Homo sapiens]
          Length = 468

 Score =  226 bits (575), Expect = 4e-59
 Identities = 148/479 (30%), Positives = 234/479 (48%), Gaps = 32/479 (6%)

Query: 1   MAVAAALTGLQAEAKCSICLDYLSDPVTIECGHNFCRSCIQQSWLDLQELFPCPVCRHQC 60
           M+ A  +  L+ E  C ICLDY S PVT ECGH+FC  C+ +SW +      CP C    
Sbjct: 1   MSTADLMENLREELTCFICLDYFSSPVTTECGHSFCLVCLLRSWEEHNTPLSCPECWRTL 60

Query: 61  QEGHFRSNTQLGRMIEIAKLLQSTK--------SNKRKQEETTLCEKHNQPLSVFCKEDL 112
           +  HF+SN +LGR+  IA+ L+S          S  R            Q  S F  +  
Sbjct: 61  EGPHFQSNERLGRLASIARQLRSQVLQSEDEQGSYGRMPTTAKALSDDEQGGSAFVAQS- 119

Query: 113 MVLCPLCTQPPDHQGHHVRPIEKAAIHYRKRFCSYIQPLKKQLADLQKLISTQSKKPLEL 172
                       H  + V    +A  H+R++    +  L+ +  + Q +++ + ++    
Sbjct: 120 ------------HGANRVHLSSEAEEHHREKLQEILNLLRVRRKEAQAVLTHEKERVKLC 167

Query: 173 REMVENQRQELSSEFEHLNQFLDREQQAVLSRLAEEEKDNQQKLSANITAFSNYSATLKS 232
           +E  +  +Q + SE+  ++QFL  E+Q  L  L +EEK+N +KL  N    +    +L  
Sbjct: 168 QEETKTCKQVVVSEYMKMHQFLKEEEQLQLQLLEQEEKENMRKLRNNEIKLTQQIRSLSK 227

Query: 233 QLSKVVELSELSELELLSQIKIFYESENESSPSIFSIHLKRDGCSFPPQYSALQRIIKKF 292
            ++++   S+ S  E L +++   E    S P +              + + ++ +++KF
Sbjct: 228 MIAQIESSSQSSAFESLEEVRGALE---RSEPLLLQCPEATTTELSLCRITGMKEMLRKF 284

Query: 293 KVEIILDPETAHPNLIVSEDKKRVRFTKRKQKVPGFPKRFTVKPVVLGFPYFHSGRHFWE 352
             EI LDP TA+  L++SED K V++   +Q++P  P+RF     VLG   F SGRH+WE
Sbjct: 285 STEITLDPATANAYLVLSEDLKSVKYGGSRQQLPDNPERFDQSATVLGTQIFTSGRHYWE 344

Query: 353 IEVGDKSEWAIGICKDSLPTKARRPSSAQQECWRIELQ-DDGYHAPGAFPTP-LLLEVKA 410
           +EVG+K+EW +GICKDS+  K   P         I L+  D Y    + P     +    
Sbjct: 345 VEVGNKTEWEVGICKDSVSRKGNLPKPPGDLFSLIGLKIGDDYSLWVSSPLKGQHVREPV 404

Query: 411 RAIGIFLDYEMGEISFYNMAEKSHICTFTD-TFTGPLRPYF-----YVGPDSQPLRICT 463
             +G+FLDYE G I+FYN  ++S I +F   +F   LRP F       G ++ PL IC+
Sbjct: 405 CKVGVFLDYESGHIAFYNGTDESLIYSFPQASFQEALRPIFSPCLPNEGTNTDPLTICS 463


>gi|18079262 tripartite motif-containing 6 isoform 2 [Homo sapiens]
          Length = 488

 Score =  218 bits (555), Expect = 9e-57
 Identities = 140/472 (29%), Positives = 239/472 (50%), Gaps = 33/472 (6%)

Query: 7   LTGLQAEAKCSICLDYLSDPVTIECGHNFCRSCI----QQSWLDLQELFPCPVCRHQCQE 62
           L  ++ E  C ICL+ L++P++I+CGH+FC++CI    ++S +  +    CPVC+   Q 
Sbjct: 6   LVDIREEVTCPICLELLTEPLSIDCGHSFCQACITPNGRESVIGQEGERSCPVCQTSYQP 65

Query: 63  GHFRSNTQLGRMIEIAKLLQSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMVLCPLCTQP 122
           G+ R N  L  ++   + L+       KQ +  LC  H + L +FC+ED  V+C LC + 
Sbjct: 66  GNLRPNRHLANIV---RRLREVVLGPGKQLKAVLCADHGEKLQLFCQEDGKVICWLCERS 122

Query: 123 PDHQGHHVRPIEKAAIHYRKRFCSYIQPLKKQLADLQKLISTQSKKPLELREMVENQRQE 182
            +H+GHH   +E+ A  Y+++F   ++ LK +  + +KL +   +K    +  +E +R  
Sbjct: 123 QEHRGHHTFLVEEVAQEYQEKFQESLKKLKNEEQEAEKLTAFIREKKTSWKNQMEPERCR 182

Query: 183 LSSEFEHLNQFLDREQQAVLSRLAEEEKDNQQKLSANITAFSNYSATLKSQLSKVVELSE 242
           + +EF  L   LDR +Q  L +L +EEK   + +        + + +L+  +S +    +
Sbjct: 183 IQTEFNQLRNILDRVEQRELKKLEQEEKKGLRIIEEAENDLVHQTQSLRELISDLERRCQ 242

Query: 243 LSELELLSQIK-IFYESENESSPSIFSIHLKRDGCSFPPQYSALQRI------IKKFKVE 295
            S +ELL  +  +   SE  +     ++  K       P    + R+      ++ + V+
Sbjct: 243 GSTMELLQDVSDVTERSEFWTLRKPEALPTKLRSMFRAPDLKRMLRVCRELTDVQSYWVD 302

Query: 296 IILDPETAHPNLIVSEDKKRVRFTKRKQKVPG-FPKRFTVKPVVLGFPYFHSGRHFWEIE 354
           + L+P TA+ NL++++++++VRF   K   P    K +     VLG  +F SG+H+WE++
Sbjct: 303 VTLNPHTANLNLVLAKNRRQVRFVGAKVSGPSCLEKHYDCS--VLGSQHFSSGKHYWEVD 360

Query: 355 VGDKSEWAIGICKDSL-PT----------KARRPSSAQQECWRIELQDDGYHAPGAFPTP 403
           V  K+ W +G+C +SL PT           A      Q   W I LQ +  +      +P
Sbjct: 361 VAKKTAWILGVCSNSLGPTFSFNHFAQNHSAYSRYQPQSGYWVIGLQHNHEYRAYEDSSP 420

Query: 404 LLL---EVKARAIGIFLDYEMGEISFYNMAEKSH-ICTFTD-TFTGPLRPYF 450
            LL    V  R +G+FLDYE G +SFYN+      I TF+   F   L PYF
Sbjct: 421 SLLLSMTVPPRRVGVFLDYEAGTVSFYNVTNHGFPIYTFSKYYFPTTLCPYF 472


>gi|51477692 tripartite motif-containing 6 isoform 1 [Homo sapiens]
          Length = 516

 Score =  218 bits (555), Expect = 9e-57
 Identities = 140/472 (29%), Positives = 239/472 (50%), Gaps = 33/472 (6%)

Query: 7   LTGLQAEAKCSICLDYLSDPVTIECGHNFCRSCI----QQSWLDLQELFPCPVCRHQCQE 62
           L  ++ E  C ICL+ L++P++I+CGH+FC++CI    ++S +  +    CPVC+   Q 
Sbjct: 34  LVDIREEVTCPICLELLTEPLSIDCGHSFCQACITPNGRESVIGQEGERSCPVCQTSYQP 93

Query: 63  GHFRSNTQLGRMIEIAKLLQSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMVLCPLCTQP 122
           G+ R N  L  ++   + L+       KQ +  LC  H + L +FC+ED  V+C LC + 
Sbjct: 94  GNLRPNRHLANIV---RRLREVVLGPGKQLKAVLCADHGEKLQLFCQEDGKVICWLCERS 150

Query: 123 PDHQGHHVRPIEKAAIHYRKRFCSYIQPLKKQLADLQKLISTQSKKPLELREMVENQRQE 182
            +H+GHH   +E+ A  Y+++F   ++ LK +  + +KL +   +K    +  +E +R  
Sbjct: 151 QEHRGHHTFLVEEVAQEYQEKFQESLKKLKNEEQEAEKLTAFIREKKTSWKNQMEPERCR 210

Query: 183 LSSEFEHLNQFLDREQQAVLSRLAEEEKDNQQKLSANITAFSNYSATLKSQLSKVVELSE 242
           + +EF  L   LDR +Q  L +L +EEK   + +        + + +L+  +S +    +
Sbjct: 211 IQTEFNQLRNILDRVEQRELKKLEQEEKKGLRIIEEAENDLVHQTQSLRELISDLERRCQ 270

Query: 243 LSELELLSQIK-IFYESENESSPSIFSIHLKRDGCSFPPQYSALQRI------IKKFKVE 295
            S +ELL  +  +   SE  +     ++  K       P    + R+      ++ + V+
Sbjct: 271 GSTMELLQDVSDVTERSEFWTLRKPEALPTKLRSMFRAPDLKRMLRVCRELTDVQSYWVD 330

Query: 296 IILDPETAHPNLIVSEDKKRVRFTKRKQKVPG-FPKRFTVKPVVLGFPYFHSGRHFWEIE 354
           + L+P TA+ NL++++++++VRF   K   P    K +     VLG  +F SG+H+WE++
Sbjct: 331 VTLNPHTANLNLVLAKNRRQVRFVGAKVSGPSCLEKHYDCS--VLGSQHFSSGKHYWEVD 388

Query: 355 VGDKSEWAIGICKDSL-PT----------KARRPSSAQQECWRIELQDDGYHAPGAFPTP 403
           V  K+ W +G+C +SL PT           A      Q   W I LQ +  +      +P
Sbjct: 389 VAKKTAWILGVCSNSLGPTFSFNHFAQNHSAYSRYQPQSGYWVIGLQHNHEYRAYEDSSP 448

Query: 404 LLL---EVKARAIGIFLDYEMGEISFYNMAEKSH-ICTFTD-TFTGPLRPYF 450
            LL    V  R +G+FLDYE G +SFYN+      I TF+   F   L PYF
Sbjct: 449 SLLLSMTVPPRRVGVFLDYEAGTVSFYNVTNHGFPIYTFSKYYFPTTLCPYF 500


>gi|68160935 tripartite motif-containing 17 isoform 2 [Homo sapiens]
          Length = 450

 Score =  218 bits (554), Expect = 1e-56
 Identities = 135/455 (29%), Positives = 238/455 (52%), Gaps = 31/455 (6%)

Query: 31  CGHNFCRSCIQQSWLDLQEL---------FPCPVCRHQCQEGHFRSNTQLGRMIEIAKLL 81
           CGHNFCR+CIQ SW   +           FPCP CR    + +   N  L ++ E+A+  
Sbjct: 4   CGHNFCRACIQLSWEKARGKKGRRKRKGSFPCPECREMSPQRNLLPNRLLTKVAEMAQ-- 61

Query: 82  QSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMVLCPLCTQPPDHQGHHVRPIEKAAIHYR 141
                  +KQ+   LC++H++PL +FC++D   +C +C +  +H+ H V P E+A   Y+
Sbjct: 62  --QHPGLQKQD---LCQEHHEPLKLFCQKDQSPICVVCRESREHRLHRVLPAEEAVQGYK 116

Query: 142 KRFCSYIQPLKKQLADLQKLISTQSKKPLELREMVENQRQELSSEFEHLNQFLDREQQAV 201
            +    ++ L++Q+     L + + +   E +  V+ +R+ +  EFE +N +L  E+Q +
Sbjct: 117 LKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVKERRERIVLEFEKMNLYLVEEEQRL 176

Query: 202 LSRLAEEEKDNQQKLSANITAFSNYSATLKSQLSKVVELSELSELELLSQIKIFYESENE 261
           L  L  EE++   +L  ++        +L+  L ++ E S    L++L  +K     +N 
Sbjct: 177 LQALETEEEETASRLRESVACLDRQGHSLELLLLQLEERSTQGPLQMLQDMKEPLSRKNN 236

Query: 262 SS---PSIFSIHLKRDGCSFPPQYSALQRIIKKFKVEIILDPETAHPNLIVSEDKKRVRF 318
            S   P +      R  C  P Q      +++ F  +++ D  +A+P L++ E ++R R+
Sbjct: 237 VSVQCPEVAPPTRPRTVCRVPGQI----EVLRGFLEDVVPDATSAYPYLLLYESRQR-RY 291

Query: 319 TKRKQKVPGF--PKRFTVKPVVLGFPYFHSGRHFWEI--EVGDKSEWAIGICKDSLPTKA 374
                +  GF    RF   P  +G   F SGRH+WE+   +   + WA+G+C+D++  K 
Sbjct: 292 LGSSPEGSGFCSKDRFVAYPCAVGQTAFSSGRHYWEVGMNITGDALWALGVCRDNVSRKD 351

Query: 375 RRPSSAQQECWRIEL-QDDGYHAPGAFPTPLLLEVKARAIGIFLDYEMGEISFYNMAEKS 433
           R P   +   W ++L +   Y +  +  TP++L      +GIFLD+E GE+SFY++++ S
Sbjct: 352 RVPKCPENGFWVVQLSKGTKYLSTFSALTPVMLMEPPSHMGIFLDFEAGEVSFYSVSDGS 411

Query: 434 HICTFTD-TFTGPLRPYFYVG-PDSQPLRICTGTV 466
           H+ T++  TF GPL+P+F +G P S  + I T T+
Sbjct: 412 HLHTYSQATFPGPLQPFFCLGAPKSGQMVISTVTM 446


>gi|42516572 tripartite motif-containing 41 isoform 1 [Homo sapiens]
          Length = 630

 Score =  214 bits (544), Expect = 2e-55
 Identities = 129/453 (28%), Positives = 214/453 (47%), Gaps = 45/453 (9%)

Query: 51  FPCPVCRHQCQEGHFRSNTQLGRMIEIAKLLQSTKSNKRKQEETTLCEKHNQPLSVFCKE 110
           F CP CR       FR N QL  M+++ + +  T     +  +  +C KH + L +FC+ 
Sbjct: 181 FTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVTDQGICPKHQEALKLFCEV 240

Query: 111 DLMVLCPLCTQPPDHQGHHVRPIEKAAIHYRKRFCSYIQPLKKQLADLQKLISTQSKKPL 170
           D   +C +C +   H+ H V P+E+    Y+ +   +++PL+K L  +QK+ + + ++  
Sbjct: 241 DEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKEERRVT 300

Query: 171 ELREMVENQRQELSSEFEHLNQFLDREQQAVLSRLAEEEKDNQQKLSANITAFSNYSATL 230
           EL+  ++++   ++SEF  L +FL  EQ  +  RL E  +    +  A  +  +  +A L
Sbjct: 301 ELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAEQAAQL 360

Query: 231 KSQLSKVVELSELSELELLSQIKIFY---ESENESSPSIFSIHLKRDGCSFPPQYSALQR 287
              L++  E S+   L LL  IK  +   E      P ++S     D C           
Sbjct: 361 SRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPEVWS----PDPCQPHSHDFLTDA 416

Query: 288 IIKKF--------KVEIILDPETAHPNLIVSEDKKRVRFTKRKQKVPGFPKRFTVKPVVL 339
           I++K         +V++ LDP+TAHP L++S D++ VR  +R+Q+V   PKRF+    VL
Sbjct: 417 IVRKMSRMFCQAARVDLTLDPDTAHPALMLSPDRRGVRLAERRQEVADHPKRFSADCCVL 476

Query: 340 GFPYFHSGRHFWEIEVGDKSEWAIGICKDSLPTKAR------------------------ 375
           G   F SGRH+WE+EVG +  WA+G  ++S   K +                        
Sbjct: 477 GAQGFRSGRHYWEVEVGGRRGWAVGAARESTHHKEKVGPGGSSVGSGDASSSRHHHRRRR 536

Query: 376 ----RPSSAQQECWRIELQDDGYHAPGAFPTPLLL-EVKARAIGIFLDYEMGEISFYNMA 430
               +    Q+E W +      Y A  +    LL    K R  G++LDYE G + FYN  
Sbjct: 537 LHLPQQPLLQREVWCVGTNGKRYQAQSSTEQTLLSPSEKPRRFGVYLDYEAGRLGFYNAE 596

Query: 431 EKSHICTFTDTFTGP-LRPYFYVGPDSQPLRIC 462
             +H+ TF+  F G  + P+F V      +++C
Sbjct: 597 TLAHVHTFSAAFLGERVFPFFRVLSKGTRIKLC 629



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 24/35 (68%), Positives = 28/35 (80%)

Query: 10 LQAEAKCSICLDYLSDPVTIECGHNFCRSCIQQSW 44
          LQ EA C+ICLDY +DPV+I CGHNFCR C+ Q W
Sbjct: 14 LQEEAVCAICLDYFTDPVSIGCGHNFCRVCVTQLW 48


>gi|149193331 tripartite motif protein 15 [Homo sapiens]
          Length = 465

 Score =  205 bits (521), Expect = 8e-53
 Identities = 131/457 (28%), Positives = 221/457 (48%), Gaps = 38/457 (8%)

Query: 16  CSICLDYLSDPVTIECGHNFCRSCI----QQSWLDLQELFPCPVCRHQCQEGHFRSNTQL 71
           C++C   L D VTI CGH FCR C+    Q       ++  CP+C+ + Q     +   L
Sbjct: 16  CTLCAGPLEDAVTIPCGHTFCRLCLPALSQMGAQSSGKILLCPLCQEEEQAETPMAPVPL 75

Query: 72  GRMIEIAKLLQSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMVLCPLCTQPPDHQGHHVR 131
           G + E                  T CE+H + +  FC+ D   LC  C + P HQ H V 
Sbjct: 76  GPLGE------------------TYCEEHGEKIYFFCENDAEFLCVFCREGPTHQAHTVG 117

Query: 132 PIEKAAIHYRKRFCSYIQPLKKQLADLQKLISTQSKKPLELREMVENQRQELSSEFEHLN 191
            +++A   YR R  S ++ L  +  +++ +   + +K   L   +E+++ ++ + FE L 
Sbjct: 118 FLDEAIQPYRDRLRSRLEALSTERDEIEDVKCQEDQKLQVLLTQIESKKHQVETAFERLQ 177

Query: 192 QFLDREQQAVLSRLAEEEKDNQQKLSANITAFSNYSATLKSQLSKVVELSELSELELLSQ 251
           Q L++++  +L+RL E E+   ++    IT  S     L +Q+ ++ E  +    ELL  
Sbjct: 178 QELEQQRCLLLARLRELEQQIWKERDEYITKVSEEVTRLGAQVKELEEKCQQPASELLQD 237

Query: 252 IKIFY---ESENESSPSIFSIHLKRDGCSFPPQYSALQRIIKKFKVE-----------II 297
           +++     E +   SP   S  L +    F  +   L  +++ F              I 
Sbjct: 238 VRVNQSRCEMKTFVSPEAISPDLVKKIRDFHRKILTLPEMMRMFSENLAHHLEIDSGVIT 297

Query: 298 LDPETAHPNLIVSEDKKRVRFTKRKQKVPGFPKRFTVKPVVLGFPYFHSGRHFWEI--EV 355
           LDP+TA  +L++SED+K VR+T++K+ +P  P RF   P VLGFP F SGRH W++  ++
Sbjct: 298 LDPQTASRSLVLSEDRKSVRYTRQKKSLPDSPLRFDGLPAVLGFPGFSSGRHRWQVDLQL 357

Query: 356 GDKSEWAIGICKDSLPTKARRPSSAQQECWRIELQDDGYHAPGAFPTPLLLEVKARAIGI 415
           GD     +G+  + +  K     SA+   W + +      A  +  T L L    R + +
Sbjct: 358 GDGGGCTVGVAGEGVRRKGEMGLSAEDGVWAVIISHQQCWASTSPGTDLPLSEIPRGVRV 417

Query: 416 FLDYEMGEISFYNMAEKSHICTFTDTFTGPLRPYFYV 452
            LDYE G+++ +N   +  I TFT +F+G + P+F V
Sbjct: 418 ALDYEAGQVTLHNAQTQEPIFTFTASFSGKVFPFFAV 454


>gi|88999601 tripartite motif-containing 69 isoform a [Homo sapiens]
          Length = 500

 Score =  199 bits (507), Expect = 3e-51
 Identities = 137/467 (29%), Positives = 225/467 (48%), Gaps = 26/467 (5%)

Query: 13  EAKCSICLDYLSDPVTIECGHNFCRSCIQQSW-LDLQELFPCPVCRHQCQEGHFRSNTQL 71
           E  C +C D+  DP+ + CGHNFC +CIQ  W L  +E F CP C+  CQ  +   N  L
Sbjct: 38  ELHCPLCNDWFRDPLMLSCGHNFCEACIQDFWRLQAKETF-CPECKMLCQYNNCTFNPVL 96

Query: 72  GRMIEIAKLLQSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMVLCPLCTQPPDHQGHHVR 131
            +++E  K L   K + +       C +H + L +F K D  ++C  C       G    
Sbjct: 97  DKLVEKIKKLPLLKGHPQ-------CPEHGENLKLFSKPDGKLICFQCKDARLSVGQSKE 149

Query: 132 PIEKA-AIHYRKRFCSYIQ-PLKKQLADLQKLISTQSKKPLELREMVENQRQELSSEFEH 189
            ++ + A+H+     +  Q  L+  L +LQ L + Q +     +E   + +Q +S EF  
Sbjct: 150 FLQISDAVHFFTEELAIQQGQLETTLKELQTLRNMQKEAIAAHKENKLHLQQHVSMEFLK 209

Query: 190 LNQFLDREQQAVLSRLAEEEKDNQQKLSANITAFSNYSATLKSQLSKV-VELSELSELEL 248
           L+QFL  +++ +L+ L EE K   +++  N++         K  L  +  +  + +  + 
Sbjct: 210 LHQFLHSKEKDILTELREEGKALNEEMELNLSQLQEQCLLAKDMLVSIQAKTEQQNSFDF 269

Query: 249 LSQIKIFYESENE-----SSPSIFSIHLKRDGCSFPPQYSA---LQRIIKKFKVEIILDP 300
           L  I     S  +     ++  + S  L       P QY     +Q  +      + LDP
Sbjct: 270 LKDITTLLHSLEQGMKVLATRELISRKLNLGQYKGPIQYMVWREMQDTLCPGLSPLTLDP 329

Query: 301 ETAHPNLIVSEDKKRVRFTKRKQKVPGFPKRFTVKPVVLGFPYFHSGRHFWEIEVGDKSE 360
           +TAHPNL++S+ +  V     K+ +P  P+RF     VLG   F SG+ +WE+EV  K++
Sbjct: 330 KTAHPNLVLSKSQTSVWHGDIKKIMPDDPERFDSSVAVLGSRGFTSGKWYWEVEVAKKTK 389

Query: 361 WAIGICKDSLPTKARRPSSAQQECWRIELQDDGYHAPGAFPT-PLLLEVKARAIGIFLDY 419
           W +G+ ++S+  K   P + +Q  W + L++         P+  L L      +GI+LDY
Sbjct: 390 WTVGVVRESIIRKGSCPLTPEQGFWLLRLRNQTDLKALDLPSFSLTLTNNLDKVGIYLDY 449

Query: 420 EMGEISFYNMAEKSHICTFTDTFTGPLRPYFYV-----GPDSQPLRI 461
           E G++SFYN    +HI TF++TF   L PYF       G + +PL I
Sbjct: 450 EGGQLSFYNAKTMTHIYTFSNTFMEKLYPYFCPCLNDGGENKEPLHI 496


>gi|157426896 tripartite motif-containing 10 isoform 2 [Homo
           sapiens]
          Length = 395

 Score =  196 bits (499), Expect = 3e-50
 Identities = 119/369 (32%), Positives = 194/369 (52%), Gaps = 20/369 (5%)

Query: 1   MAVAAALTGLQAEAKCSICLDYLSDPVTIECGHNFCRSCIQQ----SWLDLQELFPCPVC 56
           MA AA++T L  E  C IC   L +PVTI+CGHNFCR+C+ +       DL+E   CP+C
Sbjct: 1   MASAASVTSLADEVNCPICQGTLREPVTIDCGHNFCRACLTRYCEIPGPDLEESPTCPLC 60

Query: 57  RHQCQEGHFRSNTQLGRMIEIAKLLQSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMVLC 116
           +   + G FR N QL  ++E  + LQ   +    +E+  +C++H + +  FC++D M LC
Sbjct: 61  KEPFRPGSFRPNWQLANVVENIERLQLVSTLGLGEED--VCQEHGEKIYFFCEDDEMQLC 118

Query: 117 PLCTQPPDHQGHHVRPIEKAAIHYRKRFCSYIQPLKKQLADLQKLISTQSKKPLELREMV 176
            +C +  +H  H +R +E AA  YR++    ++ L+K+  ++Q++ S ++K+   L   V
Sbjct: 119 VVCREAGEHATHTMRFLEDAAAPYREQIHKCLKCLRKEREEIQEIQSRENKRMQVLLTQV 178

Query: 177 ENQRQELSSEFEHLNQFLDREQQAVLSRLAEEEKDNQQKLSANITAFSNYSATLKSQLSK 236
             +RQ++ SEF HL +FL+ +Q  +L++L  ++ D  ++        +       + + +
Sbjct: 179 STKRQQVISEFAHLRKFLEEQQSILLAQLESQDGDILRQRDEFDLLVAGEICRFSALIEE 238

Query: 237 VVELSELSELELLSQIK---IFYESENESSPSIFSIHLKRDGCSFPPQYSALQRIIKKF- 292
           + E +E    ELL+ I+   I  E+     P   S  L +    FP Q   LQR +K F 
Sbjct: 239 LEEKNERPARELLTDIRSTLIRCETRKCRKPVAVSPELGQRIRDFPQQALPLQREMKMFL 298

Query: 293 ----------KVEIILDPETAHPNLIVSEDKKRVRFTKRKQKVPGFPKRFTVKPVVLGFP 342
                        I LDP+T+HP L++SED +R +F+ + Q  P  P+RF     VL   
Sbjct: 299 EKLCFELDYEPAHISLDPQTSHPKLLLSEDHQRAQFSYKWQNSPDNPQRFDRATCVLAHT 358

Query: 343 YFHSGRHFW 351
               GRH W
Sbjct: 359 GITGGRHTW 367


>gi|60099474 tripartite motif-containing 61 [Homo sapiens]
          Length = 209

 Score =  192 bits (489), Expect = 4e-49
 Identities = 91/178 (51%), Positives = 121/178 (67%)

Query: 1   MAVAAALTGLQAEAKCSICLDYLSDPVTIECGHNFCRSCIQQSWLDLQELFPCPVCRHQC 60
           M    AL  L+AEA C ICLDYL DPVTI CGHNFC SCI  SW DL + FPCP C   C
Sbjct: 1   MEFVTALADLRAEASCPICLDYLKDPVTISCGHNFCLSCIIMSWKDLHDSFPCPFCHFCC 60

Query: 61  QEGHFRSNTQLGRMIEIAKLLQSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMVLCPLCT 120
            E  F SN QLG + EIAK LQ     +++QEE  +C+KHNQ L+ FC++DL +LCP C+
Sbjct: 61  PERKFISNPQLGSLTEIAKQLQIRSKKRKRQEEKHVCKKHNQVLTFFCQKDLELLCPRCS 120

Query: 121 QPPDHQGHHVRPIEKAAIHYRKRFCSYIQPLKKQLADLQKLISTQSKKPLELREMVEN 178
              DHQ H V PI+KAA ++RK+   Y  P K+++  ++K+I+ Q++K LEL++ +E+
Sbjct: 121 LSTDHQHHCVWPIKKAASYHRKKLEEYNAPWKERVELIEKVITMQTRKSLELKKKMES 178


>gi|51477687 tripartite motif protein 34 isoform 1 [Homo sapiens]
          Length = 488

 Score =  192 bits (487), Expect = 7e-49
 Identities = 140/495 (28%), Positives = 240/495 (48%), Gaps = 55/495 (11%)

Query: 7   LTGLQAEAKCSICLDYLSDPVTIECGHNFCRSCI----QQSWLDLQELFPCPVCRHQCQE 62
           L  +Q E  C ICL+ L++P++++CGH+ CR+CI    +++   +     CPVC      
Sbjct: 6   LLNVQEEVTCPICLELLTEPLSLDCGHSLCRACITVSNKEAVTSMGGKSSCPVCGISYSF 65

Query: 63  GHFRSNTQLGRMIEIAKLLQSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMVLCPLCTQP 122
            H ++N  L  ++E  K ++ +  N +K++   LC+ H + L +FCKED  V+C LC + 
Sbjct: 66  EHLQANQHLANIVERLKEVKLSPDNGKKRD---LCDHHGEKLLLFCKEDRKVICWLCERS 122

Query: 123 PDHQGHHVRPIEKAAIHYRKRFCSYIQPLKKQLADLQKLISTQSKKPLELREMVENQRQE 182
            +H+GHH    E+     +++  + ++ LKK+  + +KL +   ++    +  V+ +RQ 
Sbjct: 123 QEHRGHHTVLTEEVFKECQEKLQAVLKRLKKEEEEAEKLEADIREEKTSWKYQVQTERQR 182

Query: 183 LSSEFEHLNQFLDREQQAVLSRLAEEEKDNQQKLSANITAFSNYSATLKSQLSKVVELSE 242
           + +EF+ L   L+ E+Q  L RL EEEK    K +            ++  +S V   S+
Sbjct: 183 IQTEFDQLRSILNNEEQRELQRLEEEEKKTLDKFAEAEDELVQQKQLVRELISDVECRSQ 242

Query: 243 LSELELL---SQIKIFYESENESSPSIFSIHLKRDGCSFPPQYSALQRIIKK------FK 293
            S +ELL   S I  + E      P + S  LK       P  S + ++ ++      + 
Sbjct: 243 WSTMELLQDMSGIMKWSEIWRLKKPKMVSKKLKT--VFHAPDLSRMLQMFRELTAVRCYW 300

Query: 294 VEIILDPETAHPNLIVSEDKKRVRFTKRKQKVPGFPKRFTVKPVVLGFPYFHSGRHFWEI 353
           V++ L+    + NL++SED+++V        VP +P +      VLG  YF SG+H+WE+
Sbjct: 301 VDVTLNSVNLNLNLVLSEDQRQV------ISVPIWPFQ-CYNYGVLGSQYFSSGKHYWEV 353

Query: 354 EVGDKSEWAIGI-CKDSLPTKARRPSSAQQEC----------------WRIELQDD---G 393
           +V  K+ W +G+ C+    T +R      + C                W I LQ+    G
Sbjct: 354 DVSKKTAWILGVYCR----TYSRHMKYVVRRCANRQNLYTKYRPLFGYWVIGLQNKCKYG 409

Query: 394 YHAPGAFPTP----LLLEVKARAIGIFLDYEMGEISFYNM-AEKSHICTFTD-TFTGPLR 447
                    P    L + V    +G+FLDYE G +SF+N+ +  S I  F+   F+ P+ 
Sbjct: 410 VFEESLSSDPEVLTLSMAVPPCRVGVFLDYEAGIVSFFNVTSHGSLIYKFSKCCFSQPVY 469

Query: 448 PYFYVGPDSQPLRIC 462
           PYF       P+ +C
Sbjct: 470 PYFNPWNCPAPMTLC 484


>gi|18087807 tripartite motif protein 34 isoform 1 [Homo sapiens]
          Length = 488

 Score =  192 bits (487), Expect = 7e-49
 Identities = 140/495 (28%), Positives = 240/495 (48%), Gaps = 55/495 (11%)

Query: 7   LTGLQAEAKCSICLDYLSDPVTIECGHNFCRSCI----QQSWLDLQELFPCPVCRHQCQE 62
           L  +Q E  C ICL+ L++P++++CGH+ CR+CI    +++   +     CPVC      
Sbjct: 6   LLNVQEEVTCPICLELLTEPLSLDCGHSLCRACITVSNKEAVTSMGGKSSCPVCGISYSF 65

Query: 63  GHFRSNTQLGRMIEIAKLLQSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMVLCPLCTQP 122
            H ++N  L  ++E  K ++ +  N +K++   LC+ H + L +FCKED  V+C LC + 
Sbjct: 66  EHLQANQHLANIVERLKEVKLSPDNGKKRD---LCDHHGEKLLLFCKEDRKVICWLCERS 122

Query: 123 PDHQGHHVRPIEKAAIHYRKRFCSYIQPLKKQLADLQKLISTQSKKPLELREMVENQRQE 182
            +H+GHH    E+     +++  + ++ LKK+  + +KL +   ++    +  V+ +RQ 
Sbjct: 123 QEHRGHHTVLTEEVFKECQEKLQAVLKRLKKEEEEAEKLEADIREEKTSWKYQVQTERQR 182

Query: 183 LSSEFEHLNQFLDREQQAVLSRLAEEEKDNQQKLSANITAFSNYSATLKSQLSKVVELSE 242
           + +EF+ L   L+ E+Q  L RL EEEK    K +            ++  +S V   S+
Sbjct: 183 IQTEFDQLRSILNNEEQRELQRLEEEEKKTLDKFAEAEDELVQQKQLVRELISDVECRSQ 242

Query: 243 LSELELL---SQIKIFYESENESSPSIFSIHLKRDGCSFPPQYSALQRIIKK------FK 293
            S +ELL   S I  + E      P + S  LK       P  S + ++ ++      + 
Sbjct: 243 WSTMELLQDMSGIMKWSEIWRLKKPKMVSKKLKT--VFHAPDLSRMLQMFRELTAVRCYW 300

Query: 294 VEIILDPETAHPNLIVSEDKKRVRFTKRKQKVPGFPKRFTVKPVVLGFPYFHSGRHFWEI 353
           V++ L+    + NL++SED+++V        VP +P +      VLG  YF SG+H+WE+
Sbjct: 301 VDVTLNSVNLNLNLVLSEDQRQV------ISVPIWPFQ-CYNYGVLGSQYFSSGKHYWEV 353

Query: 354 EVGDKSEWAIGI-CKDSLPTKARRPSSAQQEC----------------WRIELQDD---G 393
           +V  K+ W +G+ C+    T +R      + C                W I LQ+    G
Sbjct: 354 DVSKKTAWILGVYCR----TYSRHMKYVVRRCANRQNLYTKYRPLFGYWVIGLQNKCKYG 409

Query: 394 YHAPGAFPTP----LLLEVKARAIGIFLDYEMGEISFYNM-AEKSHICTFTD-TFTGPLR 447
                    P    L + V    +G+FLDYE G +SF+N+ +  S I  F+   F+ P+ 
Sbjct: 410 VFEESLSSDPEVLTLSMAVPPCRVGVFLDYEAGIVSFFNVTSHGSLIYKFSKCCFSQPVY 469

Query: 448 PYFYVGPDSQPLRIC 462
           PYF       P+ +C
Sbjct: 470 PYFNPWNCPAPMTLC 484


>gi|51477690 tripartite motif-containing 6 and tripartite
           motif-containing 34 [Homo sapiens]
          Length = 842

 Score =  192 bits (487), Expect = 7e-49
 Identities = 140/495 (28%), Positives = 240/495 (48%), Gaps = 55/495 (11%)

Query: 7   LTGLQAEAKCSICLDYLSDPVTIECGHNFCRSCI----QQSWLDLQELFPCPVCRHQCQE 62
           L  +Q E  C ICL+ L++P++++CGH+ CR+CI    +++   +     CPVC      
Sbjct: 360 LLNVQEEVTCPICLELLTEPLSLDCGHSLCRACITVSNKEAVTSMGGKSSCPVCGISYSF 419

Query: 63  GHFRSNTQLGRMIEIAKLLQSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMVLCPLCTQP 122
            H ++N  L  ++E  K ++ +  N +K++   LC+ H + L +FCKED  V+C LC + 
Sbjct: 420 EHLQANQHLANIVERLKEVKLSPDNGKKRD---LCDHHGEKLLLFCKEDRKVICWLCERS 476

Query: 123 PDHQGHHVRPIEKAAIHYRKRFCSYIQPLKKQLADLQKLISTQSKKPLELREMVENQRQE 182
            +H+GHH    E+     +++  + ++ LKK+  + +KL +   ++    +  V+ +RQ 
Sbjct: 477 QEHRGHHTVLTEEVFKECQEKLQAVLKRLKKEEEEAEKLEADIREEKTSWKYQVQTERQR 536

Query: 183 LSSEFEHLNQFLDREQQAVLSRLAEEEKDNQQKLSANITAFSNYSATLKSQLSKVVELSE 242
           + +EF+ L   L+ E+Q  L RL EEEK    K +            ++  +S V   S+
Sbjct: 537 IQTEFDQLRSILNNEEQRELQRLEEEEKKTLDKFAEAEDELVQQKQLVRELISDVECRSQ 596

Query: 243 LSELELL---SQIKIFYESENESSPSIFSIHLKRDGCSFPPQYSALQRIIKK------FK 293
            S +ELL   S I  + E      P + S  LK       P  S + ++ ++      + 
Sbjct: 597 WSTMELLQDMSGIMKWSEIWRLKKPKMVSKKLKT--VFHAPDLSRMLQMFRELTAVRCYW 654

Query: 294 VEIILDPETAHPNLIVSEDKKRVRFTKRKQKVPGFPKRFTVKPVVLGFPYFHSGRHFWEI 353
           V++ L+    + NL++SED+++V        VP +P +      VLG  YF SG+H+WE+
Sbjct: 655 VDVTLNSVNLNLNLVLSEDQRQV------ISVPIWPFQ-CYNYGVLGSQYFSSGKHYWEV 707

Query: 354 EVGDKSEWAIGI-CKDSLPTKARRPSSAQQEC----------------WRIELQDD---G 393
           +V  K+ W +G+ C+    T +R      + C                W I LQ+    G
Sbjct: 708 DVSKKTAWILGVYCR----TYSRHMKYVVRRCANRQNLYTKYRPLFGYWVIGLQNKCKYG 763

Query: 394 YHAPGAFPTP----LLLEVKARAIGIFLDYEMGEISFYNM-AEKSHICTFTD-TFTGPLR 447
                    P    L + V    +G+FLDYE G +SF+N+ +  S I  F+   F+ P+ 
Sbjct: 764 VFEESLSSDPEVLTLSMAVPPCRVGVFLDYEAGIVSFFNVTSHGSLIYKFSKCCFSQPVY 823

Query: 448 PYFYVGPDSQPLRIC 462
           PYF       P+ +C
Sbjct: 824 PYFNPWNCPAPMTLC 838



 Score =  141 bits (356), Expect = 1e-33
 Identities = 74/250 (29%), Positives = 134/250 (53%), Gaps = 7/250 (2%)

Query: 7   LTGLQAEAKCSICLDYLSDPVTIECGHNFCRSCI----QQSWLDLQELFPCPVCRHQCQE 62
           L  ++ E  C ICL+ L++P++I+CGH+FC++CI    ++S +  +    CPVC+   Q 
Sbjct: 34  LVDIREEVTCPICLELLTEPLSIDCGHSFCQACITPNGRESVIGQEGERSCPVCQTSYQP 93

Query: 63  GHFRSNTQLGRMIEIAKLLQSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMVLCPLCTQP 122
           G+ R N  L  ++   + L+       KQ +  LC  H + L +FC+ED  V+C LC + 
Sbjct: 94  GNLRPNRHLANIV---RRLREVVLGPGKQLKAVLCADHGEKLQLFCQEDGKVICWLCERS 150

Query: 123 PDHQGHHVRPIEKAAIHYRKRFCSYIQPLKKQLADLQKLISTQSKKPLELREMVENQRQE 182
            +H+GHH   +E+ A  Y+++F   ++ LK +  + +KL +   +K    +  +E +R  
Sbjct: 151 QEHRGHHTFLVEEVAQEYQEKFQESLKKLKNEEQEAEKLTAFIREKKTSWKNQMEPERCR 210

Query: 183 LSSEFEHLNQFLDREQQAVLSRLAEEEKDNQQKLSANITAFSNYSATLKSQLSKVVELSE 242
           + +EF  L   LDR +Q  L +L +EEK   + +        + + +L+  +S +    +
Sbjct: 211 IQTEFNQLRNILDRVEQRELKKLEQEEKKGLRIIEEAENDLVHQTQSLRELISDLERRCQ 270

Query: 243 LSELELLSQI 252
            S +ELL  +
Sbjct: 271 GSTMELLQDV 280


>gi|4557743 Mediterranean fever protein [Homo sapiens]
          Length = 781

 Score =  191 bits (486), Expect = 9e-49
 Identities = 126/405 (31%), Positives = 201/405 (49%), Gaps = 43/405 (10%)

Query: 90  KQEETTLCEKHNQPLSVFCKEDLMVLCPLCTQPPDHQGHHVRPIEKAAIHYRKRFCSYIQ 149
           KQ +   CE H++P           +C +C+   +HQGH VRPIE+ A+ ++K+    ++
Sbjct: 380 KQVQLLFCEDHDEP-----------ICLICSLSQEHQGHRVRPIEEVALEHKKKIQKQLE 428

Query: 150 PLKKQLADLQKLISTQSKKPLELREMVENQRQELSSEFEHLNQFLDREQQAVLSRLAEEE 209
            LKK     ++  S   +K +   +  E  +Q +  + E +  FL++++   ++ L +  
Sbjct: 429 HLKKLRKSGEEQRSYGEEKAVSFLKQTEALKQRVQRKLEQVYYFLEQQEHFFVASLEDVG 488

Query: 210 KDNQQKLSANITAFSNYSATLKSQLSKVVELSELSELELLSQIKIF------------YE 257
           +   Q   A  T  S   A L + + ++      SE ELL  I               + 
Sbjct: 489 QMVGQIRKAYDTRVSQDIALLDALIGELEAKECQSEWELLQDIGDILHRAKTVPVPEKWT 548

Query: 258 SENESSPSIFSIHLKRDGCSFPPQY--SALQRIIKKFK-----------VEIILDPETAH 304
           +  E    I  +H K +      +Y    L+  ++ F            V +ILD ETA+
Sbjct: 549 TPQEIKQKIQLLHQKSEFVEKSTKYFSETLRSEMEMFNVPELIGAQAHAVNVILDAETAY 608

Query: 305 PNLIVSEDKKRVRFTKRKQKVPGFPKRFTVKPVVLGFPYFHSGRHFWEIEVGDKSEWAIG 364
           PNLI S+D K VR   + +++P  P+RF    +VLG P F SGR +WE+EVGDK+ W +G
Sbjct: 609 PNLIFSDDLKSVRLGNKWERLPDGPQRFDSCIIVLGSPSFLSGRRYWEVEVGDKTAWILG 668

Query: 365 ICKDSLPTKARRPSSAQQECW-RIELQDDGYHAPGAFPTPLLLEVKARAIGIFLDYEMGE 423
            CK S+  K     S +   W  I ++++ Y A    PT LL++   + +GIF+DY +G 
Sbjct: 669 ACKTSISRKGNMTLSPENGYWVVIMMKENEYQASSVPPTRLLIKEPPKRVGIFVDYRVGS 728

Query: 424 ISFYNMAEKSHICTFTD-TFTGPLRPYFYV-----GPDSQPLRIC 462
           ISFYN+  +SHI TF   +F+GPL+P F       G ++ PL IC
Sbjct: 729 ISFYNVTARSHIYTFASCSFSGPLQPIFSPGTRDGGKNTAPLTIC 773


>gi|4508005 tripartite motif-containing 26 [Homo sapiens]
          Length = 539

 Score =  189 bits (479), Expect = 6e-48
 Identities = 140/528 (26%), Positives = 239/528 (45%), Gaps = 76/528 (14%)

Query: 1   MAVAAALTGLQAEAKCSICLDYLSDPVTIECGHNFCRSCIQQSWLDLQELFPCPVCRHQC 60
           MA +A L  L+ E  CSICLDYL DPVTI+CGH FCRSC             CP+C+   
Sbjct: 1   MATSAPLRSLEEEVTCSICLDYLRDPVTIDCGHVFCRSCTTDVRPISGSRPVCPLCKKPF 60

Query: 61  QEGHFRSNTQLGRMIEIAKLLQSTKSNK-----RKQEETTLCEKHNQPLSVFCKEDLMVL 115
           ++ + R   QL  ++E  + L+  K  +     R+Q++  LCE+H + L  +C++D  +L
Sbjct: 61  KKENIRPVWQLASLVENIERLKVDKGRQPGEVTREQQDAKLCERHREKLHYYCEDDGKLL 120

Query: 116 CPLCTQPPDHQGHHVRPIEKAAIHYRKRFCSYIQPLKKQLADLQKLISTQSKKPLELREM 175
           C +C +  +H+ H    +EKAA  +R++  +++  L++    +Q   +      L   + 
Sbjct: 121 CVMCRESREHRPHTAVLMEKAAQPHREKILNHLSTLRRDRDKIQGFQAKGEADILAALKK 180

Query: 176 VENQRQELSSEFEHLNQFLDREQQAVLSRLAEEEKDNQQKLSANITAFSNYSATLKSQLS 235
           +++QRQ + +EFE  +QFL   ++ +L +LA+ E++  +      +      A L   +S
Sbjct: 181 LQDQRQYIVAEFEQGHQFLREREEHLLEQLAKLEQELTEGREKFKSRGVGELARLALVIS 240

Query: 236 KVVELSELSELELLSQIKIF---YESENESSPSIFSIHLKRDGCSFPPQYSALQRIIKKF 292
           ++   ++    EL+   + F   Y  +        +  +K+    F  +  +LQR +++F
Sbjct: 241 ELEGKAQQPAAELMQDTRDFLNRYPRKKFWVGKPIARVVKKKTGEFSDKLLSLQRGLREF 300

Query: 293 K-----------VEIILDPETAHPNLIVSEDKKRVRFTKRKQKVPGFPKRFTVKPVVLGF 341
           +           V + LDP++A   L +SED K V +T   +     P++F  +P VLG 
Sbjct: 301 QGKLLRDLEYKTVSVTLDPQSASGYLQLSEDWKCVTYTSLYKSAYLHPQQFDCEPGVLGS 360

Query: 342 PYFHSGRHFWEIEV-----------GDKSE-------------------W---------- 361
             F  G+ +WE+EV           GD+ E                   W          
Sbjct: 361 KGFTWGKVYWEVEVEREGWSEDEEEGDEEEEGEEEEEEEEAGYGDGYDDWETDEDEESLG 420

Query: 362 -----------------AIGICKDSLPTKARRPSSAQQECWRIELQDDGYHAPGAFPTPL 404
                             +G+ +DS+  K       +   W + L   G  A  +    L
Sbjct: 421 DEEEEEEEEEEEVLESCMVGVARDSVKRKGDLSLRPEDGVWALRLSSSGIWANTSPEAEL 480

Query: 405 LLEVKARAIGIFLDYEMGEISFYNMAEKSHICTFTDTFTGPLRPYFYV 452
              ++ R +GI LDYE G ++F N   +  I TFT TFT  L P+ ++
Sbjct: 481 FPALRPRRVGIALDYEGGTVTFTNAESQELIYTFTATFTRRLVPFLWL 528


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.409 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,298,724
Number of Sequences: 37866
Number of extensions: 896229
Number of successful extensions: 4608
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 260
Number of HSP's successfully gapped in prelim test: 298
Number of HSP's that attempted gapping in prelim test: 3534
Number of HSP's gapped (non-prelim): 917
length of query: 468
length of database: 18,247,518
effective HSP length: 106
effective length of query: 362
effective length of database: 14,233,722
effective search space: 5152607364
effective search space used: 5152607364
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.