Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 157694513
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
(951 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 1917 0.0
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 810 0.0
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 776 0.0
gi|62912472 leucine-rich repeat-containing G protein-coupled rec... 742 0.0
gi|62912474 leucine-rich repeat-containing G protein-coupled rec... 564 e-160
gi|31657138 follicle stimulating hormone receptor isoform 1 prec... 205 1e-52
gi|106067657 luteinizing hormone/choriogonadotropin receptor pre... 198 2e-50
gi|31657136 follicle stimulating hormone receptor isoform 2 prec... 181 2e-45
gi|64085121 thyroid stimulating hormone receptor isoform 1 precu... 180 5e-45
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 174 4e-43
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 174 4e-43
gi|225579152 insulin-like growth factor binding protein, acid la... 172 1e-42
gi|4826772 insulin-like growth factor binding protein, acid labi... 172 1e-42
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 160 5e-39
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens] 149 9e-36
gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo... 146 1e-34
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 142 2e-33
gi|4759146 slit homolog 2 [Homo sapiens] 140 6e-33
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 140 6e-33
gi|188528675 slit homolog 1 [Homo sapiens] 136 1e-31
gi|45505137 podocan [Homo sapiens] 134 3e-31
gi|11321571 slit homolog 3 [Homo sapiens] 133 9e-31
gi|4758460 glycoprotein V (platelet) [Homo sapiens] 132 2e-30
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 129 1e-29
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 129 1e-29
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 125 1e-28
gi|19743846 decorin isoform a preproprotein [Homo sapiens] 121 4e-27
gi|4503271 decorin isoform a preproprotein [Homo sapiens] 121 4e-27
gi|12007646 nyctalopin precursor [Homo sapiens] 120 6e-27
gi|76880480 hypothetical protein LOC9865 [Homo sapiens] 120 8e-27
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 1917 bits (4966), Expect = 0.0
Identities = 951/951 (100%), Positives = 951/951 (100%)
Query: 1 MPGPLGLLCFLALGLLGSAGPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQ 60
MPGPLGLLCFLALGLLGSAGPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQ
Sbjct: 1 MPGPLGLLCFLALGLLGSAGPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQ 60
Query: 61 ALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTV 120
ALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTV
Sbjct: 61 ALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTV 120
Query: 121 PSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQ 180
PSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQ
Sbjct: 121 PSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQ 180
Query: 181 ALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEF 240
ALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEF
Sbjct: 181 ALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEF 240
Query: 241 PQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHS 300
PQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHS
Sbjct: 241 PQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHS 300
Query: 301 LVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPS 360
LVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPS
Sbjct: 301 LVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPS 360
Query: 361 FNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDV 420
FNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDV
Sbjct: 361 FNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDV 420
Query: 421 SFNELTSFPTEGLNGLNQLKLVGNFKLKEALAAKDFVNLRSLSVPYAYQCCAFWGCDSYA 480
SFNELTSFPTEGLNGLNQLKLVGNFKLKEALAAKDFVNLRSLSVPYAYQCCAFWGCDSYA
Sbjct: 421 SFNELTSFPTEGLNGLNQLKLVGNFKLKEALAAKDFVNLRSLSVPYAYQCCAFWGCDSYA 480
Query: 481 NLNTEDNSLQDHSVAQEKGTADAANVTSTLENEEHSQIIIHCTPSTGAFKPCEYLLGSWM 540
NLNTEDNSLQDHSVAQEKGTADAANVTSTLENEEHSQIIIHCTPSTGAFKPCEYLLGSWM
Sbjct: 481 NLNTEDNSLQDHSVAQEKGTADAANVTSTLENEEHSQIIIHCTPSTGAFKPCEYLLGSWM 540
Query: 541 IRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAV 600
IRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAV
Sbjct: 541 IRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAV 600
Query: 601 SWGRFAEFGIWWETGSGCKVAGFLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLK 660
SWGRFAEFGIWWETGSGCKVAGFLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLK
Sbjct: 601 SWGRFAEFGIWWETGSGCKVAGFLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLK 660
Query: 661 QFRVAALLAFLGATVAGCFPLFHRGEYSASPLCLPFPTGETPSLGFTVTLVLLNSLAFLL 720
QFRVAALLAFLGATVAGCFPLFHRGEYSASPLCLPFPTGETPSLGFTVTLVLLNSLAFLL
Sbjct: 661 QFRVAALLAFLGATVAGCFPLFHRGEYSASPLCLPFPTGETPSLGFTVTLVLLNSLAFLL 720
Query: 721 MAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISPE 780
MAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISPE
Sbjct: 721 MAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISPE 780
Query: 781 IMKSVTLIFFPLPACLNPVLYVFFNPKFKEDWKLLKRRVTKKSGSVSVSISSQGGCLEQD 840
IMKSVTLIFFPLPACLNPVLYVFFNPKFKEDWKLLKRRVTKKSGSVSVSISSQGGCLEQD
Sbjct: 781 IMKSVTLIFFPLPACLNPVLYVFFNPKFKEDWKLLKRRVTKKSGSVSVSISSQGGCLEQD 840
Query: 841 FYYDCGMYSHLQGNLTVCDCCESFLLTKPVSCKHLIKSHSCPALAVASCQRPEGYWSDCG 900
FYYDCGMYSHLQGNLTVCDCCESFLLTKPVSCKHLIKSHSCPALAVASCQRPEGYWSDCG
Sbjct: 841 FYYDCGMYSHLQGNLTVCDCCESFLLTKPVSCKHLIKSHSCPALAVASCQRPEGYWSDCG 900
Query: 901 TQSAHSDYADEEDSFVSDSSDQVQACGRACFYQSRGFPLVRYAYNLPRVKD 951
TQSAHSDYADEEDSFVSDSSDQVQACGRACFYQSRGFPLVRYAYNLPRVKD
Sbjct: 901 TQSAHSDYADEEDSFVSDSSDQVQACGRACFYQSRGFPLVRYAYNLPRVKD 951
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 810 bits (2093), Expect = 0.0
Identities = 427/828 (51%), Positives = 549/828 (66%), Gaps = 14/828 (1%)
Query: 5 LGLLCFLALGLLGSAGPSGAAPPLCAAPCSCDGDRR----VDCSGKGLTAVPEGLSAFTQ 60
L L L L GS+ SG C C C+ D R VDCS GL+ +P LS FT
Sbjct: 10 LSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTS 69
Query: 61 ALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTV 120
LD+SMNNI+QL + + FLEEL+LAGN L++I A +GL LKVL LQNNQL+ V
Sbjct: 70 YLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHV 129
Query: 121 PSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQ 180
P+EA++ L +LQSLRLDANHI+ VP F GL LRHLWLDDN+LTE+PV +L LQ
Sbjct: 130 PTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQ 189
Query: 181 ALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEF 240
A+TLALNKI IPD+AF NLSSLVVLHLHNN+I SL + CFDGL +LETLDLNYNNL EF
Sbjct: 190 AMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF 249
Query: 241 PQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHS 300
P AI+ L +LKELGFHSN+I IP+ AF GNP L TIH YDNP+ FVG SAF +L +L +
Sbjct: 250 PTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRT 309
Query: 301 LVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPS 360
L + GAS + +FP+LTGT +LESLTLTG +ISS+P +C + L+ LDLSYN + DLPS
Sbjct: 310 LTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPS 369
Query: 361 FNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDV 420
F+ C L++I L+ N+IY+IK TFQ L+SLR L+L+ N I IH AF+TL + LD+
Sbjct: 370 FSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDL 429
Query: 421 SFNELTSFPTEGLNGLNQLKLVGNFKLKEALAAKDFVNLRSLSVPYAYQCCAFWGCDSYA 480
S N L+SFP GL+GL LKL GN L+ +++++F L+ + +PYAYQCCAF C++
Sbjct: 430 SSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAYQCCAFGVCENAY 489
Query: 481 NL----NTEDNSLQDHSVAQEKGTADAANVTS----TLENEEHSQII--IHCTPSTGAFK 530
+ N DNS D ++ G A + L+ EE + + + C+PS G FK
Sbjct: 490 KISNQWNKGDNSSMDDLHKKDAGMFQAQDERDLEDFLLDFEEDLKALHSVQCSPSPGPFK 549
Query: 531 PCEYLLGSWMIRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIY 590
PCE+LL W+IR+ VW I ++AL N LV T F S + KL IG+I+ N+ G+
Sbjct: 550 PCEHLLDGWLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVS 609
Query: 591 TGILTFLDAVSWGRFAEFGIWWETGSGCKVAGFLAVFSSESAIFLLMLATVERSLSAKDI 650
+ +L +DA ++G FA G WWE G GC V GFL++F+SES++FLL LA +ER S K
Sbjct: 610 SAVLAGVDAFTFGSFARHGAWWENGVGCHVIGFLSIFASESSVFLLTLAALERGFSVKYS 669
Query: 651 MKNGKSNHLKQFRVAALLAFLGATVAGCFPLFHRGEYSASPLCLPFPTGETPSLGFTVTL 710
K +V LL L A PL +Y ASPLCLP P GE ++G+ V L
Sbjct: 670 AKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPFGEPSTMGYMVAL 729
Query: 711 VLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAP 770
+LLNSL FL+M + YTKLYCNL+K DL SM+KH+A L+FTNCI CPVAF SF+
Sbjct: 730 ILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSS 789
Query: 771 LITAISISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDWKLLKRR 818
LI ISPE++K + L+ PLPACLNP+LY+ FNP FKED L+++
Sbjct: 790 LINLTFISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDLVSLRKQ 837
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 776 bits (2004), Expect = 0.0
Identities = 431/918 (46%), Positives = 561/918 (61%), Gaps = 37/918 (4%)
Query: 1 MPGPLGL----LC--FLALGLLGSAGPSGAAPPLCAAPCSCDGDR---RVDCSGKGLTAV 51
MP P GL LC A G A G P C APC C D DCS GL+AV
Sbjct: 1 MPSPPGLRALWLCAALCASRRAGGAPQPGPGPTACPAPCHCQEDGIMLSADCSELGLSAV 60
Query: 52 PEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLT 111
P L T LD+SMNN+T+L F + FLEEL+L+GN LS I +A SGL LK+L
Sbjct: 61 PGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILM 120
Query: 112 LQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVH 171
LQNNQL +P+EA+ L +LQSLRLDAN I+ VPE SFEGL LRHLWLDDN+LTE+PV
Sbjct: 121 LQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVR 180
Query: 172 PLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLD 231
L+NLP LQA+TLALN+IS IPD+AF NL+SLVVLHLHNN+I+ L H F+GL NLETLD
Sbjct: 181 ALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLD 240
Query: 232 LNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSA 291
LNYN L EFP AI+ L L+ELGFH+N+I IP+ AF GNPLL+TIH YDNP+ FVG SA
Sbjct: 241 LNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSA 300
Query: 292 FHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLS 351
F L LH+L + GA +Q+FP+L GT LE LTLT I +P+ +CQ+ LR L+LS
Sbjct: 301 FQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELS 360
Query: 352 YNNIRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFAT 411
+N I +LPS + C LEEI LQ N+I++I TF L SL+ LDLS N I IH AF+T
Sbjct: 361 HNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFST 420
Query: 412 LGPITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLKEALAAKDFVNLRSLSVPYAYQCC 471
L + LD++ N+LT+ P GL GL LKL GN L +A + F LR L VPYAYQCC
Sbjct: 421 LHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCC 480
Query: 472 AFWGCDSYANLNTEDNSLQDHSVAQEKGTADAANVTSTLENEEHSQI------------- 518
+ C S+ + + + H +E + EN +
Sbjct: 481 PYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLEMEDSKPH 540
Query: 519 -IIHCTPSTGAFKPCEYLLGSWMIRLTVWFIFLVALFFNLLVILTTFA-SCTSLPSSKLF 576
+ C+P+ G FKPCEYL SW IRL VW I L+++ N LV+LT FA LP K
Sbjct: 541 PSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFV 600
Query: 577 IGLISVSNLFMGIYTGILTFLDAVSWGRFAEFGIWWETGSGCKVAGFLAVFSSESAIFLL 636
+G I+ +N GI G+L +DA+++G+F+E+G WETG GC+ GFLAV SE+++ LL
Sbjct: 601 VGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLL 660
Query: 637 MLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAGCFPLFHRGEYSASPLCLPF 696
LA V+ S+S + GKS L R L A +A PL GEY ASPLCLP+
Sbjct: 661 TLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPY 720
Query: 697 --PTGETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIF 754
P G+ +LGFTV LV++NS FL++A Y KLYC+L + D +M++HVAWLIF
Sbjct: 721 APPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIF 780
Query: 755 TNCIFFCPVAFFSFAPLITAISISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDWKL 814
+ + +CPVAF SFA ++ ++PE +KSV L+ PLPACLNP+LY+ FNP F++D
Sbjct: 781 ADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDD--- 837
Query: 815 LKRRVTKKSGSVSVSISSQGGCLEQDFYYDCGMYSHLQGNLTVCDCCESFLLTKPVSCKH 874
RR+ ++G + G LE+ C L V E+ +P
Sbjct: 838 -LRRLRPRAGDSGPLAYAAAGELEKS---SCDSTQALVAFSDVDLILEASEAGRPPG--- 890
Query: 875 LIKSHSCPALAVASCQRP 892
++++ P++ + SCQ+P
Sbjct: 891 -LETYGFPSVTLISCQQP 907
>gi|62912472 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 2 [Homo sapiens]
Length = 915
Score = 742 bits (1916), Expect = 0.0
Identities = 404/855 (47%), Positives = 534/855 (62%), Gaps = 28/855 (3%)
Query: 55 LSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQN 114
+S A D+SMNN+T+L F + FLEEL+L+GN LS I +A SGL LK+L LQN
Sbjct: 12 VSIIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQN 71
Query: 115 NQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLS 174
NQL +P+EA+ L +LQSLRLDAN I+ VPE SFEGL LRHLWLDDN+LTE+PV L+
Sbjct: 72 NQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALN 131
Query: 175 NLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNY 234
NLP LQA+TLALN+IS IPD+AF NL+SLVVLHLHNN+I+ L H F+GL NLETLDLNY
Sbjct: 132 NLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNY 191
Query: 235 NNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHN 294
N L EFP AI+ L L+ELGFH+N+I IP+ AF GNPLL+TIH YDNP+ FVG SAF
Sbjct: 192 NKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQY 251
Query: 295 LSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNN 354
L LH+L + GA +Q+FP+L GT LE LTLT I +P+ +CQ+ LR L+LS+N
Sbjct: 252 LPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQ 311
Query: 355 IRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGP 414
I +LPS + C LEEI LQ N+I++I TF L SL+ LDLS N I IH AF+TL
Sbjct: 312 IEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHS 371
Query: 415 ITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLKEALAAKDFVNLRSLSVPYAYQCCAFW 474
+ LD++ N+LT+ P GL GL LKL GN L +A + F LR L VPYAYQCC +
Sbjct: 372 LVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYG 431
Query: 475 GCDSYANLNTEDNSLQDHSVAQEKGTADAANVTSTLENEEHSQI--------------II 520
C S+ + + + H +E + EN + +
Sbjct: 432 MCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLEMEDSKPHPSV 491
Query: 521 HCTPSTGAFKPCEYLLGSWMIRLTVWFIFLVALFFNLLVILTTFA-SCTSLPSSKLFIGL 579
C+P+ G FKPCEYL SW IRL VW I L+++ N LV+LT FA LP K +G
Sbjct: 492 QCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFVVGA 551
Query: 580 ISVSNLFMGIYTGILTFLDAVSWGRFAEFGIWWETGSGCKVAGFLAVFSSESAIFLLMLA 639
I+ +N GI G+L +DA+++G+F+E+G WETG GC+ GFLAV SE+++ LL LA
Sbjct: 552 IAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLA 611
Query: 640 TVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAGCFPLFHRGEYSASPLCLPF--P 697
V+ S+S + GKS L R L A +A PL GEY ASPLCLP+ P
Sbjct: 612 AVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPP 671
Query: 698 TGETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNC 757
G+ +LGFTV LV++NS FL++A Y KLYC+L + D +M++HVAWLIF +
Sbjct: 672 EGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADG 731
Query: 758 IFFCPVAFFSFAPLITAISISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDWKLLKR 817
+ +CPVAF SFA ++ ++PE +KSV L+ PLPACLNP+LY+ FNP F++D R
Sbjct: 732 LLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDD----LR 787
Query: 818 RVTKKSGSVSVSISSQGGCLEQDFYYDCGMYSHLQGNLTVCDCCESFLLTKPVSCKHLIK 877
R+ ++G + G LE+ C L V E+ +P ++
Sbjct: 788 RLRPRAGDSGPLAYAAAGELEKS---SCDSTQALVAFSDVDLILEASEAGRPPG----LE 840
Query: 878 SHSCPALAVASCQRP 892
++ P++ + SCQ+P
Sbjct: 841 TYGFPSVTLISCQQP 855
Score = 50.8 bits (120), Expect = 6e-06
Identities = 33/105 (31%), Positives = 51/105 (48%), Gaps = 2/105 (1%)
Query: 338 LCQEQKMLRTLDLSYNNIRDLPS--FNGCHALEEISLQRNQIYQIKEGTFQGLISLRILD 395
+CQ ++ DLS NN+ +L F+ LEE+ L N + I F GL SL+IL
Sbjct: 9 VCQVSIIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILM 68
Query: 396 LSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLK 440
L N + I + A L + +L + N ++ P GL+ L+
Sbjct: 69 LQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLR 113
>gi|62912474 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 3 [Homo sapiens]
Length = 828
Score = 564 bits (1454), Expect = e-160
Identities = 317/750 (42%), Positives = 437/750 (58%), Gaps = 28/750 (3%)
Query: 160 LDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQH 219
L N+LTE+ +L L+ L L+ N +S IP AF+ L SL +L L NN++ +
Sbjct: 30 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 89
Query: 220 CFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHL 279
L +L++LDLNYN L EFP AI+ L L+ELGFH+N+I IP+ AF GNPLL+TIH
Sbjct: 90 ALWELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHF 149
Query: 280 YDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLC 339
YDNP+ FVG SAF L LH+L + GA +Q+FP+L GT LE LTLT I +P+ +C
Sbjct: 150 YDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMC 209
Query: 340 QEQKMLRTLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRN 399
Q+ LR L+LS+N I +LPS + C LEEI LQ N+I++I TF L SL+ LDLS N
Sbjct: 210 QQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWN 269
Query: 400 LIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLKEALAAKDFVNL 459
I IH AF+TL + LD++ N+LT+ P GL GL LKL GN L +A + F L
Sbjct: 270 AIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKL 329
Query: 460 RSLSVPYAYQCCAFWGCDSYANLNTEDNSLQDHSVAQEKGTADAANVTSTLENEEHSQI- 518
R L VPYAYQCC + C S+ + + + H +E + EN +
Sbjct: 330 RILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLD 389
Query: 519 -------------IIHCTPSTGAFKPCEYLLGSWMIRLTVWFIFLVALFFNLLVILTTFA 565
+ C+P+ G FKPCEYL SW IRL VW I L+++ N LV+LT FA
Sbjct: 390 ELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFA 449
Query: 566 -SCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVSWGRFAEFGIWWETGSGCKVAGFL 624
LP K +G I+ +N GI G+L +DA+++G+F+E+G WETG GC+ GFL
Sbjct: 450 GGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFL 509
Query: 625 AVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAGCFPLFHR 684
AV SE+++ LL LA V+ S+S + GKS L R L A +A PL
Sbjct: 510 AVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASV 569
Query: 685 GEYSASPLCLPF--PTGETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQ 742
GEY ASPLCLP+ P G+ +LGFTV LV++NS FL++A Y KLYC+L + D
Sbjct: 570 GEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWD 629
Query: 743 SSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISPEIMKSVTLIFFPLPACLNPVLYV 802
+M++HVAWLIF + + +CPVAF SFA ++ ++PE +KSV L+ PLPACLNP+LY+
Sbjct: 630 CAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYL 689
Query: 803 FFNPKFKEDWKLLKRRVTKKSGSVSVSISSQGGCLEQDFYYDCGMYSHLQGNLTVCDCCE 862
FNP F++D RR+ ++G + G LE+ C L V E
Sbjct: 690 LFNPHFRDD----LRRLRPRAGDSGPLAYAAAGELEKS---SCDSTQALVAFSDVDLILE 742
Query: 863 SFLLTKPVSCKHLIKSHSCPALAVASCQRP 892
+ +P ++++ P++ + SCQ+P
Sbjct: 743 ASEAGRPPG----LETYGFPSVTLISCQQP 768
Score = 73.6 bits (179), Expect = 8e-13
Identities = 58/192 (30%), Positives = 84/192 (43%), Gaps = 25/192 (13%)
Query: 60 QALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKA------------------- 100
Q L NNI +PE AF P L+ + N + F+ A
Sbjct: 121 QELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQ 180
Query: 101 ----LSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLR 156
L G L++LTL ++ +PS + L L+ L L N I +P S +L
Sbjct: 181 EFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP--SLHRCQKLE 238
Query: 157 HLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSL 216
+ L N + E+ S L +LQAL L+ N I SI AF+ L SLV L L +N++ +L
Sbjct: 239 EIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTL 298
Query: 217 SQHCFDGLDNLE 228
GL +L+
Sbjct: 299 PLAGLGGLMHLK 310
Score = 48.9 bits (115), Expect = 2e-05
Identities = 33/95 (34%), Positives = 47/95 (49%), Gaps = 5/95 (5%)
Query: 60 QALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKT 119
+ + + N I ++ D F L+ L L+ N + IHP+A S L L L L +NQL T
Sbjct: 238 EEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTT 297
Query: 120 VPSEAIRGLSALQSLRLDANHITS--VPEDSFEGL 152
+P + GL L L+L N S +DSF L
Sbjct: 298 LP---LAGLGGLMHLKLKGNLALSQAFSKDSFPKL 329
>gi|31657138 follicle stimulating hormone receptor isoform 1
precursor [Homo sapiens]
Length = 695
Score = 205 bits (522), Expect = 1e-52
Identities = 160/617 (25%), Positives = 283/617 (45%), Gaps = 79/617 (12%)
Query: 252 ELGFHSNSISVIPDGAFDGNPLLRTIHLYDNP-LSFVGNSAFHNLSDLHSLVIRGASMVQ 310
EL F + VI GAF G L I + N L + F NL LH + I A+ +
Sbjct: 50 ELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNL- 108
Query: 311 QFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEI 370
L + ++PN L+ L +S I+ LP + H+L+++
Sbjct: 109 -------------LYINPEAFQNLPN--------LQYLLISNTGIKHLPDVHKIHSLQKV 147
Query: 371 SL--QRN-QIYQIKEGTFQGL-ISLRILDLSRNLIHEIHSRAF----------------- 409
L Q N I+ I+ +F GL IL L++N I EIH+ AF
Sbjct: 148 LLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNNLE 207
Query: 410 --------ATLGPITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLKEALAAKDFVNLRS 461
GP+ LD+S + S P+ GL L +L+ + LK+ + V L
Sbjct: 208 ELPNDVFHGASGPVI-LDISRTRIHSLPSYGLENLKKLRARSTYNLKKLPTLEKLVALME 266
Query: 462 LSVPYAYQCCAFWGCDSYANLNTEDNSLQDHSVAQEKG---TADAANVTSTLENEEHSQ- 517
S+ Y CCAF ++ +E + + + S+ +++ T +S E+ E S
Sbjct: 267 ASLTYPSHCCAF---ANWRRQISELHPICNKSILRQEVDYMTQARGQRSSLAEDNESSYS 323
Query: 518 ------------------IIIHCTPSTGAFKPCEYLLGSWMIRLTVWFIFLVALFFNLLV 559
+ + C+P AF PCE ++G ++R+ +WFI ++A+ N++V
Sbjct: 324 RGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNIIV 383
Query: 560 ILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVSWGRFAEFGIWWETGSGCK 619
++ S L + + ++ ++L +GIY ++ +D + ++ + I W+TG+GC
Sbjct: 384 LVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCD 443
Query: 620 VAGFLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAGCF 679
AGF VF+SE +++ L T+ER + M+ L+ ++ ++ A A F
Sbjct: 444 AAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAALF 503
Query: 680 PLFHRGEYSASPLCLPFPTGETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDL-S 738
P+F Y +CLP S + ++L++LN LAF+++ Y +Y + ++ S
Sbjct: 504 PIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRNPNIVS 563
Query: 739 ENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISPEIMKSVTLIFFPLPACLNP 798
+S + + K +A LIFT+ + P++FF+ + + I+ K + ++F P+ +C NP
Sbjct: 564 SSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANP 623
Query: 799 VLYVFFNPKFKEDWKLL 815
LY F F+ D+ +L
Sbjct: 624 FLYAIFTKNFRRDFFIL 640
Score = 70.1 bits (170), Expect = 9e-12
Identities = 60/203 (29%), Positives = 105/203 (51%), Gaps = 23/203 (11%)
Query: 60 QALDISMNNITQLPE-DAFKNFPFLEELQLA-GNDLSFIHPKALSGLKELKVLTLQNNQL 117
+ ++IS N++ ++ E D F N P L E+++ N+L +I+P+A L L+ L + N +
Sbjct: 73 EKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGI 132
Query: 118 KTVPSEAIRGLSALQSLRLDAN---HITSVPEDSFEGL-VQLRHLWLDDNSLTEVPVHPL 173
K +P + + +LQ + LD +I ++ +SF GL + LWL+ N + E+ +
Sbjct: 133 KHLPD--VHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIH-NCA 189
Query: 174 SNLPTLQALTLA-LNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDL 232
N L L L+ N + +P+ F S V+L + +I SL + GL+NL+ L
Sbjct: 190 FNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSY---GLENLKKLRA 246
Query: 233 --NYNNLGEFPQAIKALPSLKEL 253
YN +K LP+L++L
Sbjct: 247 RSTYN--------LKKLPTLEKL 261
Score = 38.1 bits (87), Expect = 0.039
Identities = 39/142 (27%), Positives = 58/142 (40%), Gaps = 14/142 (9%)
Query: 62 LDISMN-NITQLPEDAFKNFPFLEE-LQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKT 119
LDI N NI + ++F F L L N + IH A +G + ++ NN L+
Sbjct: 149 LDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNNLEE 208
Query: 120 VPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTL 179
+P++ G S L + I S+P E L +LR + L LPTL
Sbjct: 209 LPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLR----------ARSTYNLKKLPTL 258
Query: 180 QALTLALNKISSIPDF--AFTN 199
+ L + + P AF N
Sbjct: 259 EKLVALMEASLTYPSHCCAFAN 280
>gi|106067657 luteinizing hormone/choriogonadotropin receptor
precursor [Homo sapiens]
Length = 699
Score = 198 bits (503), Expect = 2e-50
Identities = 149/588 (25%), Positives = 274/588 (46%), Gaps = 43/588 (7%)
Query: 260 ISVIPDGAFDG-NPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQ-----FP 313
+ VIP AF G N +++ + L + +AF NL +L ++I+ ++ F
Sbjct: 61 VKVIPSQAFRGLNEVIKIEISQIDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFI 120
Query: 314 NLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYN-NIRDLP--SFNGCHALE-E 369
NL +L K + E + L++ N +I +P +F G +
Sbjct: 121 NLPRLKYLSICNTGIRKFPDVTKVFSSESNFI--LEICDNLHITTIPGNAFQGMNNESVT 178
Query: 370 ISLQRNQIYQIKEGTFQGLISLRILDLSRNL-IHEIHSRAF-ATLGPITNLDVSFNELTS 427
+ L N +++ F G +L L+L N+ + ++H+ AF GP T LD+S +L +
Sbjct: 179 LKLYGNGFEEVQSHAFNGT-TLTSLELKENVHLEKMHNGAFRGATGPKT-LDISSTKLQA 236
Query: 428 FPTEGLNGLNQLKLVGNFKLKEALAAKDFVNLRSLSVPYAYQCCAFWGCDSYANLNTEDN 487
P+ GL + +L ++ LK+ + + FVNL ++ Y CCAF NL T++
Sbjct: 237 LPSYGLESIQRLIATSSYSLKKLPSRETFVNLLEATLTYPSHCCAF------RNLPTKEQ 290
Query: 488 SLQDHSVAQEKGTADAANVTSTLENEEHSQIIIH-------------------CTPSTGA 528
+ HS+++ + V +S ++ C P A
Sbjct: 291 NFS-HSISENFSKQCESTVRKVNNKTLYSSMLAESELSGWDYEYGFCLPKTPRCAPEPDA 349
Query: 529 FKPCEYLLGSWMIRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMG 588
F PCE ++G +R+ +W I ++A+ N+ V+ S L + + +S ++ MG
Sbjct: 350 FNPCEDIMGYDFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMG 409
Query: 589 IYTGILTFLDAVSWGRFAEFGIWWETGSGCKVAGFLAVFSSESAIFLLMLATVERSLSAK 648
+Y ++ +D+ + G++ I W+TGSGC AGF VF+SE +++ L + T+ER +
Sbjct: 410 LYLLLIASVDSQTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTLTVITLERWHTIT 469
Query: 649 DIMKNGKSNHLKQFRVAALLAFLGATVAGCFPLFHRGEYSASPLCLPFPTGETPSLGFTV 708
+ + L+ + L +L +++ PL Y +C P T S + +
Sbjct: 470 YAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVETTLSQVYIL 529
Query: 709 TLVLLNSLAFLLMAVIYTKLYCNLEKEDL-SENSQSSMIKHVAWLIFTNCIFFCPVAFFS 767
T+++LN +AF ++ Y K+Y + +L + N + + K +A LIFT+ P++FF+
Sbjct: 530 TILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFA 589
Query: 768 FAPLITAISISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDWKLL 815
+ I+ K + ++F+P+ +C NP LY F F+ D+ LL
Sbjct: 590 ISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDFFLL 637
Score = 54.7 bits (130), Expect = 4e-07
Identities = 62/251 (24%), Positives = 111/251 (44%), Gaps = 33/251 (13%)
Query: 21 PSGAAPPLCAAPCSCDGDRRVDCSG--KGLTAVP--------------EGLSAFTQALDI 64
P LC PC+C D + C G GLT + GL+ +
Sbjct: 22 PRALREALCPEPCNCVPDGALRCPGPTAGLTRLSLAYLPVKVIPSQAFRGLNEVIKIEIS 81
Query: 65 SMNNITQLPEDAFKNFPFLEELQLAG-NDLSFIHPKALSGLKELKVLTLQNNQLKTVPSE 123
++++ ++ +AF N L E+ + +L +I P A L LK L++ N ++ P +
Sbjct: 82 QIDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFINLPRLKYLSICNTGIRKFP-D 140
Query: 124 AIRGLSALQSLRL---DANHITSVPEDSFEGL-VQLRHLWLDDNSLTEVPVHPLSNLPTL 179
+ S+ + L D HIT++P ++F+G+ + L L N EV H N TL
Sbjct: 141 VTKVFSSESNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAF-NGTTL 199
Query: 180 QALTLALN-KISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLG 238
+L L N + + + AF + L + + K+++L + GL++++ L +
Sbjct: 200 TSLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSY---GLESIQRL------IA 250
Query: 239 EFPQAIKALPS 249
++K LPS
Sbjct: 251 TSSYSLKKLPS 261
>gi|31657136 follicle stimulating hormone receptor isoform 2
precursor [Homo sapiens]
Length = 633
Score = 181 bits (460), Expect = 2e-45
Identities = 150/575 (26%), Positives = 266/575 (46%), Gaps = 57/575 (9%)
Query: 252 ELGFHSNSISVIPDGAFDGNPLLRTIHLYDNP-LSFVGNSAFHNLSDLHSLVIRGASMVQ 310
EL F + VI GAF G L I + N L + F NL LH + I A+ +
Sbjct: 50 ELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNL- 108
Query: 311 QFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEI 370
L + ++PN L+ L +S I+ LP + H+L+++
Sbjct: 109 -------------LYINPEAFQNLPN--------LQYLLISNTGIKHLPDVHKIHSLQKV 147
Query: 371 SL--QRN-QIYQIKEGTFQGL-ISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNE-L 425
L Q N I+ I+ +F GL IL L++N I EIH+ AF + L++S N L
Sbjct: 148 LLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGT-QLDELNLSDNNNL 206
Query: 426 TSFPTEGLNGLNQLKLVGNFKLKEALAAKDFVNLRSLSVPYAYQCCAFWGCDSYANLNTE 485
P + +G + G L E + LR V Y Q
Sbjct: 207 EELPNDVFHGAS-----GPVILSELHPICNKSILRQ-EVDYMTQARG------------- 247
Query: 486 DNSLQDHSVAQEKGTADAANVTSTLENEEHSQ----IIIHCTPSTGAFKPCEYLLGSWMI 541
Q S+A++ ++ + T ++ + + C+P AF PCE ++G ++
Sbjct: 248 ----QRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNIL 303
Query: 542 RLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVS 601
R+ +WFI ++A+ N++V++ S L + + ++ ++L +GIY ++ +D +
Sbjct: 304 RVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHT 363
Query: 602 WGRFAEFGIWWETGSGCKVAGFLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQ 661
++ + I W+TG+GC AGF VF+SE +++ L T+ER + M+ L+
Sbjct: 364 KSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRH 423
Query: 662 FRVAALLAFLGATVAGCFPLFHRGEYSASPLCLPFPTGETPSLGFTVTLVLLNSLAFLLM 721
++ ++ A A FP+F Y +CLP S + ++L++LN LAF+++
Sbjct: 424 AASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVI 483
Query: 722 AVIYTKLYCNLEKEDL-SENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISPE 780
Y +Y + ++ S +S + + K +A LIFT+ + P++FF+ + + I+
Sbjct: 484 CGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVS 543
Query: 781 IMKSVTLIFFPLPACLNPVLYVFFNPKFKEDWKLL 815
K + ++F P+ +C NP LY F F+ D+ +L
Sbjct: 544 KAKILLVLFHPINSCANPFLYAIFTKNFRRDFFIL 578
Score = 57.4 bits (137), Expect = 6e-08
Identities = 45/154 (29%), Positives = 81/154 (52%), Gaps = 10/154 (6%)
Query: 60 QALDISMNNITQLPE-DAFKNFPFLEELQLA-GNDLSFIHPKALSGLKELKVLTLQNNQL 117
+ ++IS N++ ++ E D F N P L E+++ N+L +I+P+A L L+ L + N +
Sbjct: 73 EKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGI 132
Query: 118 KTVPSEAIRGLSALQSLRLDAN---HITSVPEDSFEGL-VQLRHLWLDDNSLTEVPVHPL 173
K +P + + +LQ + LD +I ++ +SF GL + LWL+ N + E+ +
Sbjct: 133 KHLPD--VHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIH-NCA 189
Query: 174 SNLPTLQALTLA-LNKISSIPDFAFTNLSSLVVL 206
N L L L+ N + +P+ F S V+L
Sbjct: 190 FNGTQLDELNLSDNNNLEELPNDVFHGASGPVIL 223
Score = 47.0 bits (110), Expect = 8e-05
Identities = 41/160 (25%), Positives = 71/160 (44%), Gaps = 5/160 (3%)
Query: 116 QLKTVPSEAIRGLSALQSLRLDANHITSVPE-DSFEGLVQLRHLWLDD-NSLTEVPVHPL 173
+L+ + A G L+ + + N + V E D F L +L + ++ N+L +
Sbjct: 57 KLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAF 116
Query: 174 SNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNN-KIRSLSQHCFDGLD-NLETLD 231
NLP LQ L ++ I +PD + V+L + +N I ++ ++ F GL L
Sbjct: 117 QNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILW 176
Query: 232 LNYNNLGEFPQAIKALPSLKELGF-HSNSISVIPDGAFDG 270
LN N + E L EL +N++ +P+ F G
Sbjct: 177 LNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHG 216
>gi|64085121 thyroid stimulating hormone receptor isoform 1
precursor [Homo sapiens]
Length = 764
Score = 180 bits (457), Expect = 5e-45
Identities = 157/670 (23%), Positives = 291/670 (43%), Gaps = 68/670 (10%)
Query: 177 PTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNN-KIRSLSQHCFDGLDNLETLDL-NY 234
P+ Q L L + +IP AF+NL ++ +++ + ++ L H F L + +++ N
Sbjct: 52 PSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNT 111
Query: 235 NNLGEF-PQAIKALPSLKELGFHSNSISVIPD-GAFDGNPLLRTIHLYDNP-LSFVGNSA 291
NL P A+K LP LK LG + + + PD + + + DNP ++ + +A
Sbjct: 112 RNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNA 171
Query: 292 FHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDL- 350
F L + ++ + N G ++ GTK+ ++ N + K L +D
Sbjct: 172 FQGLCN--------ETLTLKLYN-NGFTSVQGYAFNGTKLDAVYLN---KNKYLTVIDKD 219
Query: 351 SYNNIRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFA 410
++ + PS +L + +KE + +L+ L LS + +H
Sbjct: 220 AFGGVYSGPSLLDVSQTSVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLH-------- 271
Query: 411 TLGPITNLDVSFNELTSFPTEGLNGLNQLKLVG-------NFKLKEALAAKDFVNLRSLS 463
+T D+S+ P+ NQ K+ G N ++L + VN +L+
Sbjct: 272 ----LTRADLSY------PSHCCAFKNQKKIRGILESLMCNESSMQSLRQRKSVN--ALN 319
Query: 464 VPYAYQCCAFWGCDSYANLNTEDNSLQDHSVAQ-----EKGTADAANVTSTLENEEHSQI 518
P + G DS + H+ A E+ + L+N + +
Sbjct: 320 SPLHQEYEENLG-DSIVGYKEKSKFQDTHNNAHYYVFFEEQEDEIIGFGQELKNPQEETL 378
Query: 519 IIH----------------CTPSTGAFKPCEYLLGSWMIRLTVWFIFLVALFFNLLVILT 562
CTP + F PCE ++G +R+ VWF+ L+AL N+ V+L
Sbjct: 379 QAFDSHYDYTICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLI 438
Query: 563 TFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVSWGRFAEFGIWWETGSGCKVAG 622
S L + + ++ ++ MG+Y ++ +D + + I W+TG GC AG
Sbjct: 439 LLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAG 498
Query: 623 FLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAGCFPLF 682
F VF+SE +++ L + T+ER + M+ + L+ + ++ + PL
Sbjct: 499 FFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLV 558
Query: 683 HRGEYSASPLCLPFPTGETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQ 742
Y+ +CLP T +L + V ++ LN +AF+++ Y K+Y + + +
Sbjct: 559 GISSYAKVSICLPMDTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQYNPGDK 618
Query: 743 SSMI-KHVAWLIFTNCIFFCPVAFFSFAPLITAISISPEIMKSVTLIFFPLPACLNPVLY 801
+ I K +A LIFT+ I P++F++ + ++ I+ K + ++F+PL +C NP LY
Sbjct: 619 DTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLVLFYPLNSCANPFLY 678
Query: 802 VFFNPKFKED 811
F F+ D
Sbjct: 679 AIFTKAFQRD 688
Score = 30.8 bits (68), Expect = 6.3
Identities = 38/161 (23%), Positives = 72/161 (44%), Gaps = 18/161 (11%)
Query: 55 LSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGN------DLSFIHPKALSGLKELK 108
LS T + N+T + DA K P L+ L + DL+ ++ + + E+
Sbjct: 100 LSKVTHIEIRNTRNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEI- 158
Query: 109 VLTLQNNQLKTVPSEAIRGL-SALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNS-LT 166
N + ++P A +GL + +L+L N TSV +F G +L ++L+ N LT
Sbjct: 159 ---TDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNG-TKLDAVYLNKNKYLT 214
Query: 167 EVPVHPLSNL---PTLQALTLALNKISSIPDFAFTNLSSLV 204
+ + P+L L ++ ++++P +L L+
Sbjct: 215 VIDKDAFGGVYSGPSL--LDVSQTSVTALPSKGLEHLKELI 253
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 174 bits (441), Expect = 4e-43
Identities = 125/429 (29%), Positives = 202/429 (47%), Gaps = 29/429 (6%)
Query: 22 SGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFP 81
+G A C + C+C +V+C+G + AVP L +L I +IT+L E F N
Sbjct: 24 AGLAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNIS 83
Query: 82 FLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHI 141
L L++ N+LS I P A L L+ L+L NN+L+ +P +GL +L+SL L +N +
Sbjct: 84 ALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQL 143
Query: 142 TSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLS 201
+ F L+ L L N L +P +L L L L N ++ I F +L
Sbjct: 144 LQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLG 203
Query: 202 SLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSIS 261
+L VL L+ N++ + FDGL NL+ EL N I
Sbjct: 204 NLQVLRLYENRLTDIPMGTFDGLVNLQ-----------------------ELALQQNQIG 240
Query: 262 VIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTV-H 320
++ G F N L+ ++L +N +S + S F L L+ L + G S+ + + G + +
Sbjct: 241 LLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPN 300
Query: 321 LESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLP--SFNGCHALEEISLQRNQIY 378
L L L ISS+P+N+ + L+ L LS N I + +FNG L E+SL N +
Sbjct: 301 LRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQ 360
Query: 379 QIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPT---EGLNG 435
+ F+ L +L+ + L N + ++ FA + + + + N+L + P + L
Sbjct: 361 DLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGK 420
Query: 436 LNQLKLVGN 444
L +L+L N
Sbjct: 421 LCELRLYDN 429
Score = 112 bits (279), Expect = 2e-24
Identities = 74/225 (32%), Positives = 105/225 (46%), Gaps = 1/225 (0%)
Query: 60 QALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKT 119
Q L + N +T +P F L+EL L N + + P L+ L L NN +
Sbjct: 206 QVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQ 265
Query: 120 VPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTL 179
+P L L L L N + + F + LR LWL DN ++ +P + SNL L
Sbjct: 266 LPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQL 325
Query: 180 QALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGE 239
Q L L+ N+IS I AF L+ L L LH N ++ L + F L NL+ + L N L +
Sbjct: 326 QVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQ 385
Query: 240 FPQAIKA-LPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNP 283
P I A + L + +N + +P G FD L + LYDNP
Sbjct: 386 LPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNP 430
Score = 75.1 bits (183), Expect = 3e-13
Identities = 52/179 (29%), Positives = 83/179 (46%), Gaps = 24/179 (13%)
Query: 60 QALDISMNNITQLPEDAFKNFPFLEELQLAGNDL------------------------SF 95
Q L +S N+I+QLP F P L L L GN L S
Sbjct: 254 QRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISS 313
Query: 96 IHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQL 155
+ S L++L+VL L NQ+ + A GL+ L+ L L N + + + F L L
Sbjct: 314 LPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANL 373
Query: 156 RHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIR 214
+++ L +N L ++P + +N+ L A+ L N++ ++P F +L L L L++N R
Sbjct: 374 QNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWR 432
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 174 bits (441), Expect = 4e-43
Identities = 125/429 (29%), Positives = 202/429 (47%), Gaps = 29/429 (6%)
Query: 22 SGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFP 81
+G A C + C+C +V+C+G + AVP L +L I +IT+L E F N
Sbjct: 18 AGLAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNIS 77
Query: 82 FLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHI 141
L L++ N+LS I P A L L+ L+L NN+L+ +P +GL +L+SL L +N +
Sbjct: 78 ALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQL 137
Query: 142 TSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLS 201
+ F L+ L L N L +P +L L L L N ++ I F +L
Sbjct: 138 LQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLG 197
Query: 202 SLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSIS 261
+L VL L+ N++ + FDGL NL+ EL N I
Sbjct: 198 NLQVLRLYENRLTDIPMGTFDGLVNLQ-----------------------ELALQQNQIG 234
Query: 262 VIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTV-H 320
++ G F N L+ ++L +N +S + S F L L+ L + G S+ + + G + +
Sbjct: 235 LLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPN 294
Query: 321 LESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLP--SFNGCHALEEISLQRNQIY 378
L L L ISS+P+N+ + L+ L LS N I + +FNG L E+SL N +
Sbjct: 295 LRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQ 354
Query: 379 QIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPT---EGLNG 435
+ F+ L +L+ + L N + ++ FA + + + + N+L + P + L
Sbjct: 355 DLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGK 414
Query: 436 LNQLKLVGN 444
L +L+L N
Sbjct: 415 LCELRLYDN 423
Score = 112 bits (279), Expect = 2e-24
Identities = 74/225 (32%), Positives = 105/225 (46%), Gaps = 1/225 (0%)
Query: 60 QALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKT 119
Q L + N +T +P F L+EL L N + + P L+ L L NN +
Sbjct: 200 QVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQ 259
Query: 120 VPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTL 179
+P L L L L N + + F + LR LWL DN ++ +P + SNL L
Sbjct: 260 LPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQL 319
Query: 180 QALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGE 239
Q L L+ N+IS I AF L+ L L LH N ++ L + F L NL+ + L N L +
Sbjct: 320 QVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQ 379
Query: 240 FPQAIKA-LPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNP 283
P I A + L + +N + +P G FD L + LYDNP
Sbjct: 380 LPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNP 424
Score = 75.1 bits (183), Expect = 3e-13
Identities = 52/179 (29%), Positives = 83/179 (46%), Gaps = 24/179 (13%)
Query: 60 QALDISMNNITQLPEDAFKNFPFLEELQLAGNDL------------------------SF 95
Q L +S N+I+QLP F P L L L GN L S
Sbjct: 248 QRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISS 307
Query: 96 IHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQL 155
+ S L++L+VL L NQ+ + A GL+ L+ L L N + + + F L L
Sbjct: 308 LPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANL 367
Query: 156 RHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIR 214
+++ L +N L ++P + +N+ L A+ L N++ ++P F +L L L L++N R
Sbjct: 368 QNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWR 426
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 172 bits (436), Expect = 1e-42
Identities = 138/449 (30%), Positives = 215/449 (47%), Gaps = 16/449 (3%)
Query: 7 LLCFLALGLLGSAG-----PSGAAPPLCAAPCSCDGDRRVD-----CSGKGLTAVPEGLS 56
LL ++ALG G P A P C A C C D D CS + LT +P+G+
Sbjct: 52 LLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVP 111
Query: 57 AFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQ 116
TQAL + NN++ +P AF+N L L L G L + P+AL GL+ L L L+ NQ
Sbjct: 112 GGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQ 171
Query: 117 LKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNL 176
L+++ AL SL L N ++ + + FEGL L L L NSL +P L
Sbjct: 172 LRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGL 231
Query: 177 PTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNN 236
+L+ L LA N+++ + F+ L+ L L L N +R++ + F L L+ L L+ N
Sbjct: 232 GSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNL 291
Query: 237 LGEF-PQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNL 295
+ P A L +L+ L N ++ + + F G LR + L N ++ + F +L
Sbjct: 292 IAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDL 351
Query: 296 SDLHSLVIRGASMVQQFP--NLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYN 353
L L + G + ++Q + G LE LTL ++ + + ++LS N
Sbjct: 352 HFLEELQL-GHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN 410
Query: 354 NIRDLPS--FNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFAT 411
+R+LP F G L + L+ + + +I+ TF GL LR L L N + I ++
Sbjct: 411 CLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWG 470
Query: 412 LGPITNLDVSFNELTSFPTEGLNGLNQLK 440
L + LD++ N+LT P GL +L+
Sbjct: 471 LAELLELDLTSNQLTHLPHRLFQGLGKLE 499
Score = 150 bits (379), Expect = 5e-36
Identities = 120/394 (30%), Positives = 183/394 (46%), Gaps = 26/394 (6%)
Query: 53 EGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTL 112
EGL + L++ N++ LP+ AF+ L EL LAGN L+++ P SGL EL+ L L
Sbjct: 205 EGLGSLWD-LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDL 263
Query: 113 QNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHP 172
N L+ + + L LQ L LD N I +V +F GL LR L L N + +
Sbjct: 264 SRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDT 323
Query: 173 LSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDL 232
L L+ L L+ N I+S+ F +L L L L +N+IR L++ F+GL LE L L
Sbjct: 324 FPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTL 383
Query: 233 NYNNLGEFPQ-AIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSA 291
++N L E A L ++ + N + +P+ F G L ++HL + L +
Sbjct: 384 DHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHT 443
Query: 292 FHNLSDLHSLVIRGASMVQ-QFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDL 350
F LS L L ++ +V + +L G L L LT +++ +P+ L
Sbjct: 444 FTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRL------------ 491
Query: 351 SYNNIRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFA 410
F G LE + L RN++ ++ L LD+S N + + + A
Sbjct: 492 ----------FQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLA 541
Query: 411 TLGPITNLDVSFNELTSFPTEGLNGLNQLKLVGN 444
LG + L + N L +F T GL +L L GN
Sbjct: 542 PLGRLRYLSLRNNSLRTF-TPQPPGLERLWLEGN 574
Score = 121 bits (304), Expect = 3e-27
Identities = 95/291 (32%), Positives = 143/291 (49%), Gaps = 7/291 (2%)
Query: 180 QALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGE 239
QAL L N +SS+P AF NLSSL L+L ++ SL GL+NL L L N L
Sbjct: 115 QALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRS 174
Query: 240 FPQAIKA-LPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDL 298
A P+L LG +N +S + DG F+G L ++L N L+ + ++AF L L
Sbjct: 175 LALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSL 234
Query: 299 HSLVIRGASMVQQFPNL-TGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRD 357
LV+ G + P L +G L L L+ + +I N+ + L+ L L N I
Sbjct: 235 RELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAA 294
Query: 358 LP--SFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPI 415
+ +F G AL + L N++ + E TF GL+ LR+L LS N I + R F L +
Sbjct: 295 VAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFL 354
Query: 416 TNLDVSFNELTSFPTEGLNGLNQLKL--VGNFKLKEALAAKDFVNLRSLSV 464
L + N + GL QL++ + + +L+E A F+ L +++V
Sbjct: 355 EELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGA-FLGLTNVAV 404
Score = 117 bits (292), Expect = 7e-26
Identities = 95/314 (30%), Positives = 147/314 (46%), Gaps = 7/314 (2%)
Query: 133 SLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSI 192
S+ + ++T +P D G Q LWLD N+L+ VP NL +L L L ++ S+
Sbjct: 95 SVFCSSRNLTRLP-DGVPGGTQA--LWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSL 151
Query: 193 PDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAI-KALPSLK 251
A L +L LHL N++RSL+ F L +L L+ N L + + L SL
Sbjct: 152 EPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLW 211
Query: 252 ELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVI-RGASMVQ 310
+L NS++V+PD AF G LR + L N L+++ + F L++L L + R A
Sbjct: 212 DLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAI 271
Query: 311 QFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDL--PSFNGCHALE 368
+ L+ L L I+++ K LR LDLS+N + L +F G L
Sbjct: 272 KANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLR 331
Query: 369 EISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSF 428
+ L N I ++ TF+ L L L L N I ++ R+F LG + L + N+L
Sbjct: 332 VLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEV 391
Query: 429 PTEGLNGLNQLKLV 442
GL + ++
Sbjct: 392 KAGAFLGLTNVAVM 405
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 172 bits (436), Expect = 1e-42
Identities = 138/449 (30%), Positives = 215/449 (47%), Gaps = 16/449 (3%)
Query: 7 LLCFLALGLLGSAG-----PSGAAPPLCAAPCSCDGDRRVD-----CSGKGLTAVPEGLS 56
LL ++ALG G P A P C A C C D D CS + LT +P+G+
Sbjct: 14 LLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVP 73
Query: 57 AFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQ 116
TQAL + NN++ +P AF+N L L L G L + P+AL GL+ L L L+ NQ
Sbjct: 74 GGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQ 133
Query: 117 LKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNL 176
L+++ AL SL L N ++ + + FEGL L L L NSL +P L
Sbjct: 134 LRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGL 193
Query: 177 PTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNN 236
+L+ L LA N+++ + F+ L+ L L L N +R++ + F L L+ L L+ N
Sbjct: 194 GSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNL 253
Query: 237 LGEF-PQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNL 295
+ P A L +L+ L N ++ + + F G LR + L N ++ + F +L
Sbjct: 254 IAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDL 313
Query: 296 SDLHSLVIRGASMVQQFP--NLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYN 353
L L + G + ++Q + G LE LTL ++ + + ++LS N
Sbjct: 314 HFLEELQL-GHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN 372
Query: 354 NIRDLPS--FNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFAT 411
+R+LP F G L + L+ + + +I+ TF GL LR L L N + I ++
Sbjct: 373 CLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWG 432
Query: 412 LGPITNLDVSFNELTSFPTEGLNGLNQLK 440
L + LD++ N+LT P GL +L+
Sbjct: 433 LAELLELDLTSNQLTHLPHRLFQGLGKLE 461
Score = 150 bits (379), Expect = 5e-36
Identities = 120/394 (30%), Positives = 183/394 (46%), Gaps = 26/394 (6%)
Query: 53 EGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTL 112
EGL + L++ N++ LP+ AF+ L EL LAGN L+++ P SGL EL+ L L
Sbjct: 167 EGLGSLWD-LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDL 225
Query: 113 QNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHP 172
N L+ + + L LQ L LD N I +V +F GL LR L L N + +
Sbjct: 226 SRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDT 285
Query: 173 LSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDL 232
L L+ L L+ N I+S+ F +L L L L +N+IR L++ F+GL LE L L
Sbjct: 286 FPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTL 345
Query: 233 NYNNLGEFPQ-AIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSA 291
++N L E A L ++ + N + +P+ F G L ++HL + L +
Sbjct: 346 DHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHT 405
Query: 292 FHNLSDLHSLVIRGASMVQ-QFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDL 350
F LS L L ++ +V + +L G L L LT +++ +P+ L
Sbjct: 406 FTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRL------------ 453
Query: 351 SYNNIRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFA 410
F G LE + L RN++ ++ L LD+S N + + + A
Sbjct: 454 ----------FQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLA 503
Query: 411 TLGPITNLDVSFNELTSFPTEGLNGLNQLKLVGN 444
LG + L + N L +F T GL +L L GN
Sbjct: 504 PLGRLRYLSLRNNSLRTF-TPQPPGLERLWLEGN 536
Score = 121 bits (304), Expect = 3e-27
Identities = 95/291 (32%), Positives = 143/291 (49%), Gaps = 7/291 (2%)
Query: 180 QALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGE 239
QAL L N +SS+P AF NLSSL L+L ++ SL GL+NL L L N L
Sbjct: 77 QALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRS 136
Query: 240 FPQAIKA-LPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDL 298
A P+L LG +N +S + DG F+G L ++L N L+ + ++AF L L
Sbjct: 137 LALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSL 196
Query: 299 HSLVIRGASMVQQFPNL-TGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRD 357
LV+ G + P L +G L L L+ + +I N+ + L+ L L N I
Sbjct: 197 RELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAA 256
Query: 358 LP--SFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPI 415
+ +F G AL + L N++ + E TF GL+ LR+L LS N I + R F L +
Sbjct: 257 VAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFL 316
Query: 416 TNLDVSFNELTSFPTEGLNGLNQLKL--VGNFKLKEALAAKDFVNLRSLSV 464
L + N + GL QL++ + + +L+E A F+ L +++V
Sbjct: 317 EELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGA-FLGLTNVAV 366
Score = 117 bits (292), Expect = 7e-26
Identities = 95/314 (30%), Positives = 147/314 (46%), Gaps = 7/314 (2%)
Query: 133 SLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSI 192
S+ + ++T +P D G Q LWLD N+L+ VP NL +L L L ++ S+
Sbjct: 57 SVFCSSRNLTRLP-DGVPGGTQA--LWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSL 113
Query: 193 PDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAI-KALPSLK 251
A L +L LHL N++RSL+ F L +L L+ N L + + L SL
Sbjct: 114 EPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLW 173
Query: 252 ELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVI-RGASMVQ 310
+L NS++V+PD AF G LR + L N L+++ + F L++L L + R A
Sbjct: 174 DLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAI 233
Query: 311 QFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDL--PSFNGCHALE 368
+ L+ L L I+++ K LR LDLS+N + L +F G L
Sbjct: 234 KANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLR 293
Query: 369 EISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSF 428
+ L N I ++ TF+ L L L L N I ++ R+F LG + L + N+L
Sbjct: 294 VLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEV 353
Query: 429 PTEGLNGLNQLKLV 442
GL + ++
Sbjct: 354 KAGAFLGLTNVAVM 367
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 160 bits (405), Expect = 5e-39
Identities = 122/423 (28%), Positives = 206/423 (48%), Gaps = 12/423 (2%)
Query: 7 LLCFLALGLLGSAGPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISM 66
LL L L L +G P CAA C+C GD +DC G+GL A+P L ++T++L++S
Sbjct: 20 LLWLLLLRLEPVTAAAGPRAP-CAAACTCAGD-SLDCGGRGLAALPGDLPSWTRSLNLSY 77
Query: 67 NNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIR 126
N ++++ F++ P L+E+ L N+L+ + P + + L LQ+N++++V ++
Sbjct: 78 NKLSEIDPAGFEDLPNLQEVYLNNNELTAV-PSLGAASSHVVSLFLQHNKIRSVEGSQLK 136
Query: 127 GLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLP-TLQALTLA 185
+L+ L L N+IT V F ++ L L N + + + L +L L L+
Sbjct: 137 AYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLS 196
Query: 186 LNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQ-AI 244
N+I+ +P AF L L L L+ N+IR + F GL++LE L L NN+ + A
Sbjct: 197 KNRITQLPVRAF-KLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAF 255
Query: 245 KALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIR 304
L + L NS+ + G+ G L +HL +N ++ + + LH LV+
Sbjct: 256 WGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLS 315
Query: 305 GASMVQ-QFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDL----- 358
++ + +L L L L+ IS I + + LR LDL +N I
Sbjct: 316 FNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTS 375
Query: 359 PSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNL 418
+F+G +L +++L N+I + + F GL L L+L N I + AF + + L
Sbjct: 376 GAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKEL 435
Query: 419 DVS 421
+S
Sbjct: 436 HIS 438
Score = 120 bits (300), Expect = 8e-27
Identities = 98/304 (32%), Positives = 135/304 (44%), Gaps = 25/304 (8%)
Query: 53 EGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTL 112
+GLS L +S N ITQLP AFK P L +L L N + I GL L+VL L
Sbjct: 184 DGLSRSLLTLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKL 242
Query: 113 QNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHP 172
Q N + + A GLS + L L+ N + V S GL L L L +NS+ +
Sbjct: 243 QRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKG 302
Query: 173 LSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDL 232
S L L L+ N ++ + + + LSSL VL L +N I +++ F GL +L LDL
Sbjct: 303 WSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDL 362
Query: 233 NYNNLG----EFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVG 288
++N + + A L SL +L N I + AF G L ++L N + V
Sbjct: 363 DHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQ 422
Query: 289 NSAFHNLSDLHSLVIRGAS-----------------MVQQFPNLTGTVHLESLTLTGTKI 331
AF + +L L I S M+Q F T H ES L G I
Sbjct: 423 FDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTAT-CAHPES--LKGQSI 479
Query: 332 SSIP 335
S+P
Sbjct: 480 FSVP 483
Score = 100 bits (250), Expect = 5e-21
Identities = 96/318 (30%), Positives = 140/318 (44%), Gaps = 38/318 (11%)
Query: 156 RHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRS 215
R L L N L+E+ +LP LQ + L N+++++P + S +V L L +NKIRS
Sbjct: 71 RSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAAS-SHVVSLFLQHNKIRS 129
Query: 216 LSQHCFDGLDNLETLDLNYNNLGE-----FPQAIKALPSLKELGFHSNSISVIPDGAFDG 270
+ +LE LDL+ NN+ E FP P +KEL N I + GAFDG
Sbjct: 130 VEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHG----PPIKELNLAGNRIGTLELGAFDG 185
Query: 271 -NPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGT 329
+ L T+ L N ++ + AF + P LT L L
Sbjct: 186 LSRSLLTLRLSKNRITQLPVRAF------------------KLPRLT------QLDLNRN 221
Query: 330 KISSIPNNLCQEQKMLRTLDLSYNNIRDLP--SFNGCHALEEISLQRNQIYQIKEGTFQG 387
+I I Q L L L NNI L +F G + + L+ N + ++ G+ G
Sbjct: 222 RIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYG 281
Query: 388 LISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLKLVG-NFK 446
L +L L LS N I IH + ++ + L +SFN LT E L L+ L ++ +
Sbjct: 282 LTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHN 341
Query: 447 LKEALAAKDFVNLRSLSV 464
+A F LRSL V
Sbjct: 342 SISHIAEGAFKGLRSLRV 359
>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
Length = 620
Score = 149 bits (377), Expect = 9e-36
Identities = 114/360 (31%), Positives = 180/360 (50%), Gaps = 12/360 (3%)
Query: 1 MPGPLGLLCF--LALGLLGS--AGPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLS 56
MP PL L C+ + L +LGS +G + PP C CS DR V C K AVPEG+
Sbjct: 15 MPSPL-LACWQPILLLVLGSVLSGSATGCPPRCE--CSAQ-DRAVLCHRKRFVAVPEGIP 70
Query: 57 AFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQ 116
T+ LD+ N I L +D F +FP LEEL+L N +S + P A + L L+ L L++N+
Sbjct: 71 TETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNR 130
Query: 117 LKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNL 176
LK +P GLS L L + N I + + F+ L L+ L + DN L + S L
Sbjct: 131 LKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGL 190
Query: 177 PTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNN 236
+L+ LTL ++SIP A ++L L+VL L + I ++ + F L L+ L++++
Sbjct: 191 NSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWP 250
Query: 237 LGE--FPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHN 294
+ P + L +L L +++ +P A LR ++L NP+S + S H
Sbjct: 251 YLDTMTPNCLYGL-NLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHE 309
Query: 295 LSDLHSLVIRGASMVQQFP-NLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYN 353
L L + + G + P G +L L ++G +++++ ++ L TL L N
Sbjct: 310 LLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSN 369
Score = 80.5 bits (197), Expect = 7e-15
Identities = 72/232 (31%), Positives = 111/232 (47%), Gaps = 49/232 (21%)
Query: 54 GLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQ 113
GLS T+ LDIS N I L + F++ L+ L++ NDL +I +A SGL L+ LTL+
Sbjct: 141 GLSNLTK-LDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLE 199
Query: 114 NNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHL------WLDDNS--- 164
L ++P+EA+ L L LRL +I ++ + SF+ L +L+ L +LD +
Sbjct: 200 KCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNC 259
Query: 165 ---------------LTEVPVHPLSNLPTLQALTLALNKISSIPD--------------- 194
LT VP + +L L+ L L+ N IS+I
Sbjct: 260 LYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLV 319
Query: 195 ---------FAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNL 237
+AF L+ L VL++ N++ +L + F + NLETL L+ N L
Sbjct: 320 GGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPL 371
Score = 57.0 bits (136), Expect = 8e-08
Identities = 39/122 (31%), Positives = 61/122 (50%), Gaps = 2/122 (1%)
Query: 320 HLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPS--FNGCHALEEISLQRNQI 377
HLE L L +S++ LRTL L N ++ +P F G L ++ + N+I
Sbjct: 96 HLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKI 155
Query: 378 YQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLN 437
+ + FQ L +L+ L++ N + I RAF+ L + L + LTS PTE L+ L+
Sbjct: 156 VILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLH 215
Query: 438 QL 439
L
Sbjct: 216 GL 217
Score = 43.5 bits (101), Expect = 0.001
Identities = 34/118 (28%), Positives = 55/118 (46%), Gaps = 10/118 (8%)
Query: 325 TLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLP--SFNGCHALEEISLQRNQIYQIKE 382
TL + +S P+ L L+L+ N + + +FN L + L+ N++ I
Sbjct: 85 TLNQDEFASFPH--------LEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPL 136
Query: 383 GTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLK 440
G F GL +L LD+S N I + F L + +L+V N+L +GLN L+
Sbjct: 137 GVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLE 194
Score = 34.3 bits (77), Expect = 0.57
Identities = 25/99 (25%), Positives = 43/99 (43%), Gaps = 4/99 (4%)
Query: 370 ISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFP 429
+ L +N+I + + F L L+L+ N++ + AF L + L + N L P
Sbjct: 76 LDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIP 135
Query: 430 TEGLNGLNQLKLVGNFKLKEALAA----KDFVNLRSLSV 464
GL+ L + + K + +D NL+SL V
Sbjct: 136 LGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEV 174
>gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo
sapiens]
Length = 757
Score = 146 bits (368), Expect = 1e-34
Identities = 159/679 (23%), Positives = 273/679 (40%), Gaps = 113/679 (16%)
Query: 152 LVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNN 211
L Q L D+ +L VP S + A++L N I +P F N L L+L NN
Sbjct: 105 LCQGLELDCDETNLRAVP----SVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNN 160
Query: 212 KIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDGN 271
KI S+S + A + L SL +L N I+ + G F+
Sbjct: 161 KITSISIY-----------------------AFRGLNSLTKLYLSHNRITFLKPGVFEDL 197
Query: 272 PLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKI 331
L + + DN LS + F+ L+ L LV+ + T++
Sbjct: 198 HRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVL--------------------TRL 237
Query: 332 SSIPNNLCQEQKMLRTLDLSYNNIRDLPS--FNGCHALEEISLQRNQIYQIKEGTFQGLI 389
P LCQ L LDL N+I +L + F C L + +++N+I + E TF L
Sbjct: 238 PDKP--LCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQ 295
Query: 390 SLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLKE 449
L LDL N I + F L ++ L++S+N + + L +LK + ++
Sbjct: 296 KLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEI 355
Query: 450 A-LAAKDFVNLRSLSVPY--AYQCCAFWGCDSYANLNTEDNSLQDHSVAQEKGTADAANV 506
+ + + F L +LS Y +Q C + A +V
Sbjct: 356 SNIQQRMFRPLMNLSHIYFKKFQYCGY-----------------------------APHV 386
Query: 507 TSTLENEEHSQIIIHCTPSTGAFKPCEYLLGSWMIRLTVWFIFLVALFFNLLVILTTFAS 566
S C P+T E LL S + R+ VW + V F N+ VI
Sbjct: 387 RS-------------CKPNTDGISSLENLLASIIQRVFVWVVSAVTCFGNIFVICMRPYI 433
Query: 567 CTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVSWGRFAEFGIWWETGSGCKVAGFLAV 626
+ + I + ++ MGIY ++ D G + + W + C++ G LA+
Sbjct: 434 RSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHCQLVGSLAI 493
Query: 627 FSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAGCFPL----F 682
S+E ++ LL T+E+ + + + + V L+ G VA PL F
Sbjct: 494 LSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVA-FIPLSNKEF 552
Query: 683 HRGEYSASPLCLPFPTGETPSLG---FTVTLVL-LNSLAFLLMAVIYTKLYCNLEKEDLS 738
+ Y + +C P + +T S+G ++V + L +N AF+++ Y ++ ++ + ++
Sbjct: 553 FKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAIT 612
Query: 739 E-------NSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISPEIMKSVTLIFFP 791
+ + K +++FT+ + + P+ F L+ + I I V + P
Sbjct: 613 ATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLL-QVEIPGTITSWVVIFILP 671
Query: 792 LPACLNPVLYVFFNPKFKE 810
+ + LNP+LY FKE
Sbjct: 672 INSALNPILYTLTTRPFKE 690
Score = 120 bits (301), Expect = 6e-27
Identities = 95/308 (30%), Positives = 144/308 (46%), Gaps = 10/308 (3%)
Query: 33 CSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGND 92
C C G +DC L AVP +S+ A+ + N I +LP D FKN+ L++L L N
Sbjct: 104 CLCQG-LELDCDETNLRAVPS-VSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNK 161
Query: 93 LSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGL 152
++ I A GL L L L +N++ + L L+ L ++ NH++ + +F GL
Sbjct: 162 ITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGL 221
Query: 153 VQLRHLWLDDNSLTEVPVHPL-SNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNN 211
L L L +N LT +P PL ++P L L L N I ++ + F + S+L VL + N
Sbjct: 222 NSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKN 281
Query: 212 KIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAI-KALPSLKELGFHSNSISVIPDGAFDG 270
KI L+++ F L L+ LDL N + P I K L L +L N I I FD
Sbjct: 282 KINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDY 341
Query: 271 NPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTK 330
L+++ L +S + F L +L + + +F H+ S
Sbjct: 342 LVKLKSLSLEGIEISNIQQRMFRPLMNLSHIYFK------KFQYCGYAPHVRSCKPNTDG 395
Query: 331 ISSIPNNL 338
ISS+ N L
Sbjct: 396 ISSLENLL 403
Score = 53.1 bits (126), Expect = 1e-06
Identities = 37/138 (26%), Positives = 59/138 (42%)
Query: 67 NNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIR 126
N I L E+ F L+EL L N + + P LKEL L L N ++ + +
Sbjct: 281 NKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFD 340
Query: 127 GLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLAL 186
L L+SL L+ I+++ + F L+ L H++ H S P ++
Sbjct: 341 YLVKLKSLSLEGIEISNIQQRMFRPLMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLE 400
Query: 187 NKISSIPDFAFTNLSSLV 204
N ++SI F + S V
Sbjct: 401 NLLASIIQRVFVWVVSAV 418
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 142 bits (357), Expect = 2e-33
Identities = 130/441 (29%), Positives = 215/441 (48%), Gaps = 27/441 (6%)
Query: 5 LGLLCFLALGLLGSAG---------PSG-AAPPLCAAPCSCDGDRRVDCSGKGLTAVPEG 54
LGLL LG G + PSG AA C C C GD +DCS K L +PE
Sbjct: 13 LGLLLCAVLGRAGRSDSGGRGELGQPSGVAAERPCPTTCRCLGDL-LDCSRKRLARLPEP 71
Query: 55 LSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQN 114
L ++ LD+S N ++ + + + L E++L N+L I P + +L+L
Sbjct: 72 LPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETI-PNLGPVSANITLLSLAG 130
Query: 115 NQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLS 174
N++ + E ++ +L++L L +N+I+ + + +F L QL++L+L+ N +T +
Sbjct: 131 NRIVEILPEHLKEFQSLETLDLSSNNISEL-QTAFPAL-QLKYLYLNSNRVTSMEPGYFD 188
Query: 175 NLP-TLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLN 233
NL TL L L N+IS+IP F L L L L+ NKI+++ F GL L++L +
Sbjct: 189 NLANTLLVLKLNRNRISAIPPKMF-KLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQ 247
Query: 234 YNNLGEFPQ-AIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAF 292
N + + A L +++ L N+++ I G G +L+ +HL N ++ + A+
Sbjct: 248 RNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAW 307
Query: 293 H---NLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLD 349
LS+L L S + + G L +L + ++S I + + L+TLD
Sbjct: 308 EFCQKLSEL-DLTFNHLSRLDD-SSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLD 365
Query: 350 LSYNNI----RDLP-SFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEI 404
L N I D+ +F+G L + LQ N+I I + F GL +L LDLS N I +
Sbjct: 366 LKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSL 425
Query: 405 HSRAFATLGPITNLDVSFNEL 425
AF+ + + L ++ + L
Sbjct: 426 QGNAFSQMKKLQQLHLNTSSL 446
Score = 112 bits (281), Expect = 1e-24
Identities = 75/252 (29%), Positives = 120/252 (47%), Gaps = 5/252 (1%)
Query: 62 LDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVP 121
L ++ N I+ +P FK P L+ L+L N + + GL LK L +Q N + +
Sbjct: 197 LKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLM 255
Query: 122 SEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQA 181
A GLS ++ L+LD N++T + + GL+ L+ L L N++ + L
Sbjct: 256 DGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSE 315
Query: 182 LTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLG--- 238
L L N +S + D +F LS L LH+ NN++ ++ F GL +L+TLDL N +
Sbjct: 316 LDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTI 375
Query: 239 -EFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSD 297
+ A L L+ L N I I AF G L + L DN + + +AF +
Sbjct: 376 EDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKK 435
Query: 298 LHSLVIRGASMV 309
L L + +S++
Sbjct: 436 LQQLHLNTSSLL 447
Score = 90.1 bits (222), Expect = 9e-18
Identities = 76/272 (27%), Positives = 121/272 (44%), Gaps = 17/272 (6%)
Query: 60 QALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKT 119
Q L+++ N I + F+ L+ L++ N ++ + A GL +++L L +N L
Sbjct: 218 QHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTE 277
Query: 120 VPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTL 179
+ + GL LQ L L N I + D++E +L L L N L+ + L L
Sbjct: 278 ITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLL 337
Query: 180 QALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQH---CFDGLDNLETLDLNYNN 236
L + N++S I D AF LSSL L L NN+I + F GLD L L L N
Sbjct: 338 NTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNR 397
Query: 237 LGEF-PQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPL----------S 285
+ +A L +L+ L N+I + AF L+ +HL + L
Sbjct: 398 IRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQ 457
Query: 286 FVGNS---AFHNLSDLHSLVIRGASMVQQFPN 314
+V + +F N S H +++G S+ P+
Sbjct: 458 WVAENNFQSFVNASCAHPQLLKGRSIFAVSPD 489
Score = 86.7 bits (213), Expect = 1e-16
Identities = 85/334 (25%), Positives = 147/334 (44%), Gaps = 47/334 (14%)
Query: 160 LDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQH 219
L N L+ + +S+L +L+ + L N++ +IP+ + +++ +L L N+I +
Sbjct: 81 LSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS-ANITLLSLAGNRIVEILPE 139
Query: 220 CFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDG--NPLLRTI 277
+LETLDL+ NN+ E A AL LK L +SN ++ + G FD N LL +
Sbjct: 140 HLKEFQSLETLDLSSNNISELQTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLL-VL 197
Query: 278 HLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNN 337
L N +S + P + L+ L L KI ++
Sbjct: 198 KLNRNRISAIP------------------------PKMFKLPQLQHLELNRNKIKNVDGL 233
Query: 338 LCQEQKMLRTLDLSYNNIRDLP--SFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILD 395
Q L++L + N + L +F G +E + L N + +I +G GL+ L+ L
Sbjct: 234 TFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELH 293
Query: 396 LSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLKEALAAKD 455
LS+N I+ I A+ ++ LD++FN L+ GL+ L +
Sbjct: 294 LSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLL---------------N 338
Query: 456 FVNLRSLSVPYAYQCCAFWGCDSYANLNTEDNSL 489
+++ + V Y CAF G S L+ ++N +
Sbjct: 339 TLHIGNNRVSYIAD-CAFRGLSSLKTLDLKNNEI 371
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 140 bits (353), Expect = 6e-33
Identities = 129/430 (30%), Positives = 187/430 (43%), Gaps = 47/430 (10%)
Query: 11 LALGLLGSAGPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNIT 70
L+LGL+ A + AP C A CSC G VDC G L +VP + T+ LD++ NNIT
Sbjct: 11 LSLGLV-LAILNKVAPQACPAQCSCSGST-VDCHGLALRSVPRNIPRNTERLDLNGNNIT 68
Query: 71 QLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSA 130
++ + F L LQL N +S I A LKEL+ L L N L+ P G +
Sbjct: 69 RITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAK 128
Query: 131 LQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKIS 190
L L L N I ++P +F G V +++L LD N+IS
Sbjct: 129 LYRLDLSENQIQAIPRKAFRGAVDIKNLQLD------------------------YNQIS 164
Query: 191 SIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNL---GEFPQAIKAL 247
I D AF L L VL L+NN I LS F+ + L T L+ NNL L
Sbjct: 165 CIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWL 224
Query: 248 PSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHS------- 300
+G ++ + + + + + SF+ S S LH
Sbjct: 225 RQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSGHQSFMAPSC----SVLHCPAACTCS 280
Query: 301 ---LVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRD 357
+ RG + + NL T+ + L I IP K LR +DLS N I +
Sbjct: 281 NNIVDCRGKGLTEIPTNLPETI--TEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISE 338
Query: 358 L--PSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPI 415
L +F G +L + L N+I ++ + F+GL SL++L L+ N I+ + AF L +
Sbjct: 339 LAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNL 398
Query: 416 TNLDVSFNEL 425
L + N+L
Sbjct: 399 NLLSLYDNKL 408
Score = 121 bits (304), Expect = 3e-27
Identities = 114/418 (27%), Positives = 176/418 (42%), Gaps = 73/418 (17%)
Query: 29 CAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQL 88
C A C+C + VDC GKGLT +P L + + N I +P AF + L + L
Sbjct: 273 CPAACTCSNNI-VDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDL 331
Query: 89 AGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDS 148
+ N +S + P A GL+ L L L N++ +P GL +LQ L L+AN I + D+
Sbjct: 332 SNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDA 391
Query: 149 FEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALN------KISSIPDFAFTN--- 199
F+ L L L L DN L + S L +Q + LA N + + D+ TN
Sbjct: 392 FQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIE 451
Query: 200 -----------LSSLVVLHLHNNKIR-----------------SLSQHCFDGLDNLE--- 228
L++ + + + K R LS CF L E
Sbjct: 452 TSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSKLSGDCFADLACPEKCR 511
Query: 229 ----TLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVI-PDGAFDGNPLLRTIHLYDNP 283
T+D + L + P+ I + EL ++N +V+ G F P LR I+ +N
Sbjct: 512 CEGTTVDCSNQKLNKIPEHIPQYTA--ELRLNNNEFTVLEATGIFKKLPQLRKINFSNNK 569
Query: 284 LSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQK 343
++ + AF GAS V + + LT ++ ++ + + + +
Sbjct: 570 ITDIEEGAF-----------EGASGVNE------------ILLTSNRLENVQHKMFKGLE 606
Query: 344 MLRTLDLSYNNIRDL--PSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRN 399
L+TL L N I + SF G ++ +SL NQI + G F L SL L+L N
Sbjct: 607 SLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLAN 664
Score = 100 bits (248), Expect = 8e-21
Identities = 104/416 (25%), Positives = 175/416 (42%), Gaps = 52/416 (12%)
Query: 117 LKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNL 176
L++VP R L L+ N+IT + + F GL LR L L +N ++ + +L
Sbjct: 46 LRSVPRNIPRNTERLD---LNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDL 102
Query: 177 PTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNN 236
L+ L L N + P+ F + L L L N+I+++ + F G +++ L L+YN
Sbjct: 103 KELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQ 162
Query: 237 LGEFPQ-AIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAF--- 292
+ A +AL L+ L ++N+I+ + +F+ P LRT L+ N L + A+
Sbjct: 163 ISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSD 222
Query: 293 ----------------------HNLSDL---------HSLVIRGASMVQQFPNLTGTVHL 321
HN++++ H + + V P T
Sbjct: 223 WLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAAC-TCSN 281
Query: 322 ESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLP--SFNGCHALEEISLQRNQIYQ 379
+ G ++ IP NL + +R L N I+ +P +F+ L I L NQI +
Sbjct: 282 NIVDCRGKGLTEIPTNLPETITEIR---LEQNTIKVIPPGAFSPYKKLRRIDLSNNQISE 338
Query: 380 IKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQL 439
+ FQGL SL L L N I E+ F L + L ++ N++ + L+ L
Sbjct: 339 LAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNL 398
Query: 440 KLVGNFKLK-EALAAKDFVNLRSLSV------PYAYQCCAFWGCDSYANLNTEDNS 488
L+ + K + +A F LR++ P+ C W D Y + N + S
Sbjct: 399 NLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLAD-YLHTNPIETS 453
Score = 97.1 bits (240), Expect = 7e-20
Identities = 93/385 (24%), Positives = 161/385 (41%), Gaps = 39/385 (10%)
Query: 29 CAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDA-FKNFPFLEELQ 87
C C C+G VDCS + L +PE + +T L ++ N T L FK P
Sbjct: 506 CPEKCRCEGTT-VDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLP------ 558
Query: 88 LAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPED 147
+L+ + NN++ + A G S + + L +N + +V
Sbjct: 559 ------------------QLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHK 600
Query: 148 SFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLH 207
F+GL L+ L L N +T V L +++ L+L N+I+++ AF L SL L+
Sbjct: 601 MFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLN 660
Query: 208 LHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKALP----SLKEL----GFHSNS 259
L N + G + + N + P +K +P ++++ G NS
Sbjct: 661 LLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNS 720
Query: 260 ISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTV 319
S + + L + + L + ++++L+ + G L+
Sbjct: 721 CSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELY---LDGNQFTLVPKELSNYK 777
Query: 320 HLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLP--SFNGCHALEEISLQRNQI 377
HL + L+ +IS++ N L TL LSYN +R +P +F+G +L +SL N I
Sbjct: 778 HLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDI 837
Query: 378 YQIKEGTFQGLISLRILDLSRNLIH 402
+ EG F L +L L + N ++
Sbjct: 838 SVVPEGAFNDLSALSHLAIGANPLY 862
Score = 68.9 bits (167), Expect = 2e-11
Identities = 72/313 (23%), Positives = 136/313 (43%), Gaps = 17/313 (5%)
Query: 141 ITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPL-SNLPTLQALTLALNKISSIPDFAFTN 199
+ +PE + +LR L++N T + + LP L+ + + NKI+ I + AF
Sbjct: 524 LNKIPEHIPQYTAELR---LNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEG 580
Query: 200 LSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLG-EFPQAIKALPSLKELGFHSN 258
S + + L +N++ ++ F GL++L+TL L N + + L S++ L + N
Sbjct: 581 ASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDN 640
Query: 259 SISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGT 318
I+ + GAFD L T++L NP + A+ ++ G Q+ P
Sbjct: 641 QITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQK-PYFLKE 699
Query: 319 VHLESLTLTG-TKISSIPNNLCQEQKMLRT--------LDLSYNNIRDLPSFNGCHALEE 369
+ ++ + + T +N C T + S ++ LP + E
Sbjct: 700 IPIQDVAIQDFTCDDGNDDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPK-GIPRDVTE 758
Query: 370 ISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFP 429
+ L NQ + + L ++DLS N I + +++F+ + + L +S+N L P
Sbjct: 759 LYLDGNQ-FTLVPKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIP 817
Query: 430 TEGLNGLNQLKLV 442
+GL L+L+
Sbjct: 818 PRTFDGLKSLRLL 830
Score = 53.9 bits (128), Expect = 7e-07
Identities = 44/148 (29%), Positives = 62/148 (41%), Gaps = 9/148 (6%)
Query: 297 DLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIR 356
D H L +R S+ + P T E L L G I+ I + LR L L N I
Sbjct: 40 DCHGLALR--SVPRNIPRNT-----ERLDLNGNNITRITKTDFAGLRHLRVLQLMENKIS 92
Query: 357 DLP--SFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGP 414
+ +F LE + L RN + E F G L LDLS N I I +AF
Sbjct: 93 TIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVD 152
Query: 415 ITNLDVSFNELTSFPTEGLNGLNQLKLV 442
I NL + +N+++ L L+++
Sbjct: 153 IKNLQLDYNQISCIEDGAFRALRDLEVL 180
>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
sapiens]
Length = 606
Score = 140 bits (353), Expect = 6e-33
Identities = 100/353 (28%), Positives = 171/353 (48%), Gaps = 27/353 (7%)
Query: 29 CAAPCSCDGDRR-VDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQ 87
C A C C + V C + L A+PEG+ T+ LD+S N + + + F ++P LEE+
Sbjct: 28 CPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEEID 87
Query: 88 LAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPED 147
L+ N ++ + P A + L L+ L L+ N+LK VP GLS L L + N I + +
Sbjct: 88 LSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDY 147
Query: 148 SFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLH 207
F+ L L+ L + DN L + S L +L+ LTL ++++P A ++L SL+ LH
Sbjct: 148 MFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLH 207
Query: 208 LHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKALP-SLKELGFHSNSISVIPDG 266
L + I ++ + F L +L+ L+++Y L + A +L L + ++S +P
Sbjct: 208 LKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPFL 267
Query: 267 AFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTL 326
AF L ++L NP+S + F +L + L+ L +
Sbjct: 268 AFKHLVYLTHLNLSYNPISTIEAGMFSDL-----------------------IRLQELHI 304
Query: 327 TGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPS--FNGCHALEEISLQRNQI 377
G ++ +I + Q + LR L++S N + L F+ ALE +S+ N +
Sbjct: 305 VGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPL 357
Score = 110 bits (274), Expect = 8e-24
Identities = 96/324 (29%), Positives = 153/324 (47%), Gaps = 28/324 (8%)
Query: 106 ELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSL 165
E K+L L N+LK+V E L+ + L N I +V +F L LR L L N L
Sbjct: 58 ETKILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRL 117
Query: 166 TEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLD 225
VP+ + L L L ++ NKI + D+ F +L +L L + +N + +S F GL
Sbjct: 118 KLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLL 177
Query: 226 NLETLDLNYNNLGEFP-QAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPL 284
+LE L L NL P +A+ L SL L +I+ +P +Y
Sbjct: 178 SLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMP--------------VY---- 219
Query: 285 SFVGNSAFHNLSDLHSLVIRGASMVQQFP-NLTGTVHLESLTLTGTKISSIPNNLCQEQK 343
AF L L L I ++ P N ++L SL++T T +S++P +
Sbjct: 220 ------AFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPFLAFKHLV 273
Query: 344 MLRTLDLSYNNIRDLPS--FNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLI 401
L L+LSYN I + + F+ L+E+ + Q+ I+ +FQGL LR+L++S+NL+
Sbjct: 274 YLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLL 333
Query: 402 HEIHSRAFATLGPITNLDVSFNEL 425
+ F++ + L ++ N L
Sbjct: 334 ETLEENVFSSPRALEVLSINNNPL 357
Score = 48.9 bits (115), Expect = 2e-05
Identities = 54/220 (24%), Positives = 83/220 (37%), Gaps = 49/220 (22%)
Query: 251 KELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQ 310
K L N + + F PLL I L DN ++ V AF+NL
Sbjct: 60 KILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNL--------------- 104
Query: 311 QFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEI 370
+L SL L G ++ +P L F G L ++
Sbjct: 105 --------FNLRSLRLKGNRLKLVP----------------------LGVFTGLSNLTKL 134
Query: 371 SLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPT 430
+ N+I + + FQ L +L+ L++ N + I RAF+ L + L + LT+ PT
Sbjct: 135 DISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPT 194
Query: 431 EGLNGLNQLKLVG----NFKLKEALAAKDFVNLRSLSVPY 466
E L+ L L + N A K +L+ L + Y
Sbjct: 195 EALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDY 234
Score = 48.1 bits (113), Expect = 4e-05
Identities = 38/128 (29%), Positives = 62/128 (48%), Gaps = 8/128 (6%)
Query: 322 ESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDL--PSFNGCHALEEISLQRNQIYQ 379
+S++ ++ +IP + E K+L DLS N ++ + F LEEI L N I
Sbjct: 39 KSVSCHRRRLIAIPEGIPIETKIL---DLSKNRLKSVNPEEFISYPLLEEIDLSDNIIAN 95
Query: 380 IKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNE---LTSFPTEGLNGL 436
++ G F L +LR L L N + + F L +T LD+S N+ L + + L+ L
Sbjct: 96 VEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNL 155
Query: 437 NQLKLVGN 444
L++ N
Sbjct: 156 KSLEVGDN 163
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 136 bits (342), Expect = 1e-31
Identities = 124/425 (29%), Positives = 192/425 (45%), Gaps = 25/425 (5%)
Query: 5 LGLLCFLALGLLGSAGPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDI 64
L LL + A LG++ C A C+C G VDC G GL A+P+ + T+ L++
Sbjct: 18 LWLLLWAAAWRLGASA--------CPALCTCTGTT-VDCHGTGLQAIPKNIPRNTERLEL 68
Query: 65 SMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEA 124
+ NNIT++ ++ F L LQL N + + A +KEL+ L L NQL +P
Sbjct: 69 NGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELL 128
Query: 125 IRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTL 184
+ AL L L N I ++P +F G L++L LD N ++ + L L+ LTL
Sbjct: 129 FQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTL 188
Query: 185 ALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAI 244
N I++IP +F ++ L LH+N + C L L +G F Q
Sbjct: 189 NNNNITTIPVSSFNHMPKLRTFRLHSNHL-----FCDCHLAWLSQWLRQRPTIGLFTQC- 242
Query: 245 KALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIR 304
SL+ L +++ + F + + LS A S+ + R
Sbjct: 243 SGPASLRGL-----NVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSN-GIVDCR 296
Query: 305 GASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDL--PSFN 362
G + NL T+ L L G I SIP + LR +DLS N I ++ +F
Sbjct: 297 GKGLTAIPANLPETMTEIRLELNG--IKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQ 354
Query: 363 GCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSF 422
G +L + L N+I + G F GL +L++L L+ N I+ I AF L ++ L +
Sbjct: 355 GLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYD 414
Query: 423 NELTS 427
N++ S
Sbjct: 415 NKIQS 419
Score = 117 bits (292), Expect = 7e-26
Identities = 102/392 (26%), Positives = 163/392 (41%), Gaps = 69/392 (17%)
Query: 29 CAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQL 88
C A C+C VDC GKGLTA+P L + + +N I +P AF + L + L
Sbjct: 282 CPAMCTCSNGI-VDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDL 340
Query: 89 AGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDS 148
+ N ++ I P A GL+ L L L N++ +P GL LQ L L+AN I + D+
Sbjct: 341 SNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDA 400
Query: 149 FEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALN------KISSIPDFAFTN--- 199
F+ L L L L DN + + ++L +Q L LA N + + DF TN
Sbjct: 401 FQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIE 460
Query: 200 -----------LSSLVVLHLHNNKIR--SLSQHCFDGLDNLE------------------ 228
L++ + + + K R + Q+ G ++ +
Sbjct: 461 TSGARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYQLNSECNSDVVCPHKCRCE 520
Query: 229 ---------------------TLDLNYNN----LGEFPQAIKALPSLKELGFHSNSISVI 263
T +L NN + E K L LK++ +N +S I
Sbjct: 521 ANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEI 580
Query: 264 PDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRG--ASMVQQFPNLTGTVHL 321
DGAF+G + +HL N L + + F L L +L++R S + + TG ++
Sbjct: 581 EDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHN-DSFTGLRNV 639
Query: 322 ESLTLTGTKISSIPNNLCQEQKMLRTLDLSYN 353
L+L +I+++ + L TL+L N
Sbjct: 640 RLLSLYDNQITTVSPGAFDTLQSLSTLNLLAN 671
Score = 109 bits (273), Expect = 1e-23
Identities = 106/417 (25%), Positives = 172/417 (41%), Gaps = 72/417 (17%)
Query: 117 LKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNL 176
L+ +P R L+ L+ N+IT + ++ F GL QLR L L +N + V ++
Sbjct: 52 LQAIPKNIPRNTERLE---LNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDM 108
Query: 177 PTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNN 236
L+ L L N++ +P+ F N +L L L N I+++ + F G +L+ L L+ N
Sbjct: 109 KELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQ 168
Query: 237 LGEFPQ-AIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNL 295
+ + A +AL L+ L ++N+I+ IP +F+ P LRT L+ N H
Sbjct: 169 ISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSN----------HLF 218
Query: 296 SDLH----SLVIRGASMVQQFPNLTGTVHLESLTLT------------------------ 327
D H S +R + F +G L L +
Sbjct: 219 CDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLS 278
Query: 328 ------------------GTKISSIPNNLCQEQKMLRTLDLSYNNIRDLP--SFNGCHAL 367
G +++IP NL + +R L N I+ +P +F+ L
Sbjct: 279 SGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIR---LELNGIKSIPPGAFSPYRKL 335
Query: 368 EEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTS 427
I L NQI +I FQGL SL L L N I ++ F L + L ++ N++
Sbjct: 336 RRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINC 395
Query: 428 FPTEGLNGLNQLKLVGNFKLK-EALAAKDFVNLRSLSV------PYAYQCCAFWGCD 477
+ L L L+ + K ++LA F +LR++ P+ C W D
Sbjct: 396 IRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLAD 452
Score = 97.1 bits (240), Expect = 7e-20
Identities = 100/376 (26%), Positives = 160/376 (42%), Gaps = 52/376 (13%)
Query: 28 LCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDA-FKNFPFLEEL 86
+C C C+ + V+CS LT +PE + T L ++ N I+ L FK L+++
Sbjct: 512 VCPHKCRCEANV-VECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKI 570
Query: 87 QLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPE 146
L+ N +S I A G + L L NQL+++ S RGL L++L L N I+ +
Sbjct: 571 NLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHN 630
Query: 147 DSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVL 206
DSF GL +R L L DN +T V L +L L L N + A+
Sbjct: 631 DSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLG------G 684
Query: 207 HLHNNKIRSLSQHCF--DGLDNLETLDLNYNNL---------GEFPQA------------ 243
L KI + + C D L + D+ + + G P+
Sbjct: 685 WLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRPQCPQECACLDTV 744
Query: 244 -------IKALP-----SLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSA 291
++ALP ++ EL N +++P G L+ + L +N +S + NS+
Sbjct: 745 VRCSNKHLRALPKGIPKNVTELYLDGNQFTLVP-GQLSTFKYLQLVDLSNNKISSLSNSS 803
Query: 292 FHNLSDLHSLVIRGASMVQQFPNLT--GTVHLESLTLTGTKISSIPNNLCQEQKMLRTLD 349
F N+S L +L++ + +Q P L G L L+L G IS++ + + L L
Sbjct: 804 FTNMSQLTTLIL-SYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLA 862
Query: 350 LSYNNIRDLPSFNGCH 365
+ N P + CH
Sbjct: 863 IGAN-----PLYCDCH 873
Score = 86.7 bits (213), Expect = 1e-16
Identities = 94/353 (26%), Positives = 156/353 (44%), Gaps = 26/353 (7%)
Query: 141 ITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPL-SNLPTLQALTLALNKISSIPDFAFTN 199
+T +PE + +LR L++N ++ + + L L+ + L+ NK+S I D AF
Sbjct: 531 LTKIPERIPQSTAELR---LNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEG 587
Query: 200 LSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLG-EFPQAIKALPSLKELGFHSN 258
+S+ LHL N++ S+ F GLD L TL L N + + L +++ L + N
Sbjct: 588 AASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDN 647
Query: 259 SISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGT 318
I+ + GAFD L T++L NP + A+ ++ G Q P+
Sbjct: 648 QITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRKRKIVTGNPRCQN-PDFLRQ 706
Query: 319 VHLESLTLTGTKISS-------IPNNLC-QEQKMLRT-LDLSYNNIRDLPSFNGCHALEE 369
+ L+ + + +P C QE L T + S ++R LP + E
Sbjct: 707 IPLQDVAFPDFRCEEGQEEGGCLPRPQCPQECACLDTVVRCSNKHLRALPK-GIPKNVTE 765
Query: 370 ISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFP 429
+ L NQ + + G L+++DLS N I + + +F + +T L +S+N L P
Sbjct: 766 LYLDGNQ-FTLVPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIP 824
Query: 430 T---EGLNGLNQLKLVGN--FKLKEALAAKDFVNLRSLSV---PYAYQCCAFW 474
+GL L L L GN L+E + A D +L L++ P C W
Sbjct: 825 PLAFQGLRSLRLLSLHGNDISTLQEGIFA-DVTSLSHLAIGANPLYCDCHLRW 876
Score = 70.1 bits (170), Expect = 9e-12
Identities = 43/139 (30%), Positives = 69/139 (49%), Gaps = 2/139 (1%)
Query: 27 PLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEEL 86
P C C+C D V CS K L A+P+G+ L + N T +P F +L+ +
Sbjct: 732 PQCPQECACL-DTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPGQ-LSTFKYLQLV 789
Query: 87 QLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPE 146
L+ N +S + + + + +L L L N L+ +P A +GL +L+ L L N I+++ E
Sbjct: 790 DLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQE 849
Query: 147 DSFEGLVQLRHLWLDDNSL 165
F + L HL + N L
Sbjct: 850 GIFADVTSLSHLAIGANPL 868
Score = 55.1 bits (131), Expect = 3e-07
Identities = 40/138 (28%), Positives = 63/138 (45%), Gaps = 9/138 (6%)
Query: 305 GASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPS--FN 362
GAS TGT ++ GT + +IP N+ + + L +L+ NNI + F
Sbjct: 30 GASACPALCTCTGT----TVDCHGTGLQAIPKNIPRNTERL---ELNGNNITRIHKNDFA 82
Query: 363 GCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSF 422
G L + L NQI ++ G F + L L L+RN +H + F ++ LD+S
Sbjct: 83 GLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSE 142
Query: 423 NELTSFPTEGLNGLNQLK 440
N + + P + G LK
Sbjct: 143 NAIQAIPRKAFRGATDLK 160
>gi|45505137 podocan [Homo sapiens]
Length = 661
Score = 134 bits (338), Expect = 3e-31
Identities = 144/487 (29%), Positives = 207/487 (42%), Gaps = 76/487 (15%)
Query: 20 GPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKN 79
GP G A C C+C + VDC G L P L T L + N + ++ +
Sbjct: 108 GP-GPAAVSCPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIYPEELSR 166
Query: 80 FPFLEELQLAGNDLSF--IHPKALSGLKELKVLTLQNNQLKTVPSEAIRGL-SALQSLRL 136
LE L L N L+ + KA L L L L NN+L P R L +AL S+
Sbjct: 167 LHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTLAP----RFLPNALISVDF 222
Query: 137 DANHITSV--------------------------PEDSFEGLVQLRHLWLDDNSLTEVPV 170
AN++T + P++ F G + L L N L VP
Sbjct: 223 AANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPK 282
Query: 171 HPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKI--RSLSQHCFDGLDNLE 228
H P L L L NK+ IP AF+ LSSL L+L NN + L F L +LE
Sbjct: 283 H---LPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLE 339
Query: 229 TLDLNYNNLGEFP----------------------QAIKALPSLKELGFHSNSI--SVIP 264
LDL+ NNL P + + SL+ L HSN + I
Sbjct: 340 YLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIH 399
Query: 265 DGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESL 324
AF G L T+HLY+N L V + + L L + + ++ + T LE L
Sbjct: 400 PLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGRE--DFATTYFLEEL 457
Query: 325 TLTGTKISS--IPNNLCQEQKMLRTLDLSYNNIRDLPSF--NGCHALEEISLQRNQIYQI 380
L+ +I+S + + ++ ++LR+LDLS N + LP H L+ ++RN++ +
Sbjct: 458 NLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLK---VKRNELAAL 514
Query: 381 KEGTFQGLISLRILDLSRNLIHE--IHSRAFATLGPITNLDVSFNELTSFPTEGL-NGLN 437
G G+ LR L L+ N + + RA+ L + LD++ N+LT P EGL L
Sbjct: 515 ARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIP-EGLPESLE 573
Query: 438 QLKLVGN 444
L L N
Sbjct: 574 YLYLQNN 580
Score = 87.4 bits (215), Expect = 6e-17
Identities = 101/388 (26%), Positives = 157/388 (40%), Gaps = 60/388 (15%)
Query: 44 SGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSF--IHPKAL 101
S L VP+ L L + N + ++P AF L EL L N L+ + +
Sbjct: 273 SSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETF 332
Query: 102 SGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLD 161
L L+ L L +N L VP+ R L L L+ N I SV + + L +L L
Sbjct: 333 WKLSSLEYLDLSSNNLSRVPAGLPRSLVLLH---LEKNAIRSVDANVLTPIRSLEYLLLH 389
Query: 162 DNSLTEVPVHPLS--NLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQH 219
N L E +HPL+ L L + L N + +P + +L++LH N+I + +
Sbjct: 390 SNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILH---NQITGIGRE 446
Query: 220 CFDGLDNLETLDLNYNNLGEFPQ----AIKALPSLKELGFHSNSISVIPDG--------- 266
F LE L+L+YN + PQ A + L L+ L N + +P G
Sbjct: 447 DFATTYFLEELNLSYNRITS-PQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLK 505
Query: 267 ------------AFDGNPLLRTIHLYDNPLSF--VGNSAFHNLSDLHSLVIRGASMVQQF 312
A G LR ++L N L +G A+ +L+ L L I G + +
Sbjct: 506 VKRNELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIP 565
Query: 313 PNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEISL 372
L + LE L L KIS++P N L+ + L +N +
Sbjct: 566 EGLPES--LEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKL----------------- 606
Query: 373 QRNQIYQIKEGTFQGLISLRILDLSRNL 400
+ + + F+ L L++LD+ NL
Sbjct: 607 ---AVGSVVDSAFRRLKHLQVLDIEGNL 631
Score = 42.7 bits (99), Expect = 0.002
Identities = 26/77 (33%), Positives = 42/77 (54%), Gaps = 2/77 (2%)
Query: 41 VDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSF--IHP 98
+D +G LT +PEGL + L + N I+ +P +AF + P L+ + L N L+ +
Sbjct: 554 LDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVD 613
Query: 99 KALSGLKELKVLTLQNN 115
A LK L+VL ++ N
Sbjct: 614 SAFRRLKHLQVLDIEGN 630
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 133 bits (334), Expect = 9e-31
Identities = 117/417 (28%), Positives = 184/417 (44%), Gaps = 19/417 (4%)
Query: 11 LALGLLGSAGPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNIT 70
LAL L ++ SG C C+C VDC G GL AVP G+ + LD+ NNIT
Sbjct: 16 LALALALASVLSGPPAVACPTKCTCSA-ASVDCHGLGLRAVPRGIPRNAERLDLDRNNIT 74
Query: 71 QLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSA 130
++ + F L L L N +S I A LK+L+ L L N+L+ +P +
Sbjct: 75 RITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPK 134
Query: 131 LQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKIS 190
L L L N I +P +F G+ +++L LD+N ++ + L L+ LTL N IS
Sbjct: 135 LTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNIS 194
Query: 191 SIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSL 250
I +F ++ + L LH+N + +C L L +G+F + +
Sbjct: 195 RILVTSFNHMPKIRTLRLHSNHL-----YCDCHLAWLSDWLRQRRTVGQF---TLCMAPV 246
Query: 251 KELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQ 310
GF N V P N +S N + + RG +++
Sbjct: 247 HLRGF--NVADVQKKEYVCPAPHSEPPSCNANSISCPSPCTCSN----NIVDCRGKGLME 300
Query: 311 QFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDL--PSFNGCHALE 368
NL + + L I +IP + K L+ +D+S N I D+ +F G +L
Sbjct: 301 IPANLPEGI--VEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLT 358
Query: 369 EISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNEL 425
+ L N+I +I +G F GL+SL++L L+ N I+ + F L + L + N+L
Sbjct: 359 SLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKL 415
Score = 115 bits (288), Expect = 2e-25
Identities = 101/378 (26%), Positives = 159/378 (42%), Gaps = 24/378 (6%)
Query: 28 LCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDA-FKNFPFLEEL 86
+C C C+G VDCS + L +P L + L ++ N ++ L FK P L ++
Sbjct: 504 VCPEKCRCEGTI-VDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKI 562
Query: 87 QLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPE 146
L+ N + + A G ++ L L NQL+TV RGLS L++L L +N I V
Sbjct: 563 NLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSN 622
Query: 147 DSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVL 206
D+F GL +R L L DN +T + + L +L + L N + A+
Sbjct: 623 DTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLG------K 676
Query: 207 HLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDG 266
L +I S + C L E P A+ G +S + P
Sbjct: 677 WLRKRRIVSGNPRCQKPF-----------FLKEIPIQDVAIQDFTCDGNEESSCQLSPRC 725
Query: 267 AFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTL 326
+ + + L + ++++L+ + G + L+ HL + L
Sbjct: 726 PEQCTCMETVVRCSNKGLRALPRGMPKDVTELY---LEGNHLTAVPRELSALRHLTLIDL 782
Query: 327 TGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLP--SFNGCHALEEISLQRNQIYQIKEGT 384
+ IS + N L TL LSYN +R +P +FNG +L ++L N I + EG+
Sbjct: 783 SNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGS 842
Query: 385 FQGLISLRILDLSRNLIH 402
F L SL L L N +H
Sbjct: 843 FNDLTSLSHLALGTNPLH 860
Score = 112 bits (280), Expect = 2e-24
Identities = 110/408 (26%), Positives = 174/408 (42%), Gaps = 61/408 (14%)
Query: 29 CAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQL 88
C +PC+C + VDC GKGL +P L + + N+I +P AF + L+ + +
Sbjct: 280 CPSPCTCSNNI-VDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDI 338
Query: 89 AGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDS 148
+ N +S I P A GLK L L L N++ + GL +LQ L L+AN I + ++
Sbjct: 339 SKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNT 398
Query: 149 FEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALN------KISSIPDFAFTN--- 199
F+ L L L L DN L + + L ++Q L LA N + + D+ N
Sbjct: 399 FQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIE 458
Query: 200 -----------LSSLVVLHLHNNKIR---------SLSQHCFDGLDNLETLDLNYNNLGE 239
L++ + + + K R S CF L E +
Sbjct: 459 TSGARCSSPRRLANKRISQIKSKKFRCSGSEDYRSRFSSECFMDLVCPEKCRCEGTIVDC 518
Query: 240 FPQAIKALPS-----LKELGFHSNSISVI-PDGAFDGNPLLRTIHLYDNPLSFVGNSAFH 293
Q + +PS + +L + N +SV+ G F P LR I+L +N + V AF
Sbjct: 519 SNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFD 578
Query: 294 NLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYN 353
GA+ VQ+ L LTG ++ ++ + + L+TL L N
Sbjct: 579 -----------GAASVQE------------LMLTGNQLETVHGRVFRGLSGLKTLMLRSN 615
Query: 354 NIRDL--PSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRN 399
I + +F G ++ +SL N+I I G F L+SL ++L N
Sbjct: 616 LIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSN 663
Score = 104 bits (259), Expect = 4e-22
Identities = 96/355 (27%), Positives = 166/355 (46%), Gaps = 25/355 (7%)
Query: 132 QSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISS 191
+ L LD N+IT + + F GL LR L L+DN ++ + +L L+ L L NK+
Sbjct: 64 ERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQV 123
Query: 192 IPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQ-AIKALPSL 250
+P+ F + L L L N+I+ + + F G+ +++ L L+ N++ A +AL L
Sbjct: 124 LPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDL 183
Query: 251 KELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQ 310
+ L ++N+IS I +F+ P +RT+ L+ N L + A+ LSD +R V
Sbjct: 184 EILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAW--LSDW----LRQRRTVG 237
Query: 311 QFPNLTGTVHLESLTLTGTK----ISSIPNN---LCQEQKML---------RTLDLSYNN 354
QF VHL + + + P++ C + +D
Sbjct: 238 QFTLCMAPVHLRGFNVADVQKKEYVCPAPHSEPPSCNANSISCPSPCTCSNNIVDCRGKG 297
Query: 355 IRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGP 414
+ ++P+ N + EI L++N I I G F L+ +D+S+N I +I AF L
Sbjct: 298 LMEIPA-NLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKS 356
Query: 415 ITNLDVSFNELTSFPTEGLNGLNQLK-LVGNFKLKEALAAKDFVNLRSLSVPYAY 468
+T+L + N++T +GL L+ L+ N L F +L++L++ Y
Sbjct: 357 LTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLY 411
Score = 81.6 bits (200), Expect = 3e-15
Identities = 51/149 (34%), Positives = 72/149 (48%), Gaps = 2/149 (1%)
Query: 17 GSAGPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDA 76
G+ S P C C+C + V CS KGL A+P G+ L + N++T +P +
Sbjct: 713 GNEESSCQLSPRCPEQCTCM-ETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRE- 770
Query: 77 FKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRL 136
L + L+ N +S + S + L L L N+L+ +P A GL +L+ L L
Sbjct: 771 LSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTL 830
Query: 137 DANHITSVPEDSFEGLVQLRHLWLDDNSL 165
N I+SVPE SF L L HL L N L
Sbjct: 831 HGNDISSVPEGSFNDLTSLSHLALGTNPL 859
Score = 78.2 bits (191), Expect = 3e-14
Identities = 81/313 (25%), Positives = 137/313 (43%), Gaps = 18/313 (5%)
Query: 141 ITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPL-SNLPTLQALTLALNKISSIPDFAFTN 199
+ +P E + LR L+DN ++ + + LP L+ + L+ NKI + + AF
Sbjct: 523 LVRIPSHLPEYVTDLR---LNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDG 579
Query: 200 LSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLG-EFPQAIKALPSLKELGFHSN 258
+S+ L L N++ ++ F GL L+TL L N +G L S++ L + N
Sbjct: 580 AASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDN 639
Query: 259 SISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQ------QF 312
I+ I GAF L TI+L NP + + A+ ++ G Q +
Sbjct: 640 RITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQKPFFLKEI 699
Query: 313 PNLTGTVHLESLTLTGTKISSIP-NNLCQEQ--KMLRTLDLSYNNIRDLPSFNGCHALEE 369
P V ++ T G + SS + C EQ M + S +R LP + E
Sbjct: 700 P--IQDVAIQDFTCDGNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALPR-GMPKDVTE 756
Query: 370 ISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFP 429
+ L+ N + + L L ++DLS N I + + F+ + ++ L +S+N L P
Sbjct: 757 LYLEGNHLTAVPR-ELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIP 815
Query: 430 TEGLNGLNQLKLV 442
NGL L+++
Sbjct: 816 VHAFNGLRSLRVL 828
Score = 51.6 bits (122), Expect = 3e-06
Identities = 34/125 (27%), Positives = 58/125 (46%), Gaps = 5/125 (4%)
Query: 318 TVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPS--FNGCHALEEISLQRN 375
T S+ G + ++P + + + L DL NNI + F G L + L+ N
Sbjct: 39 TCSAASVDCHGLGLRAVPRGIPRNAERL---DLDRNNITRITKMDFAGLKNLRVLHLEDN 95
Query: 376 QIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNG 435
Q+ I+ G FQ L L L L++N + + F + +T LD+S N++ P + G
Sbjct: 96 QVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRG 155
Query: 436 LNQLK 440
+ +K
Sbjct: 156 ITDVK 160
>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
Length = 560
Score = 132 bits (332), Expect = 2e-30
Identities = 111/427 (25%), Positives = 188/427 (44%), Gaps = 18/427 (4%)
Query: 6 GLLCFLALGLLGSAGPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDIS 65
G L LGLL A P C C C CSG + + L T I
Sbjct: 4 GTLLCAVLGLLR------AQPFPCPPACKCVFRDAAQCSGGDVARI-SALGLPTNLTHIL 56
Query: 66 MNNITQ--LPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSE 123
+ + + L +F L+ L ++ + +S + P S L +LK L L N++ +P
Sbjct: 57 LFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGA 116
Query: 124 AIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALT 183
+ + L+ L LD N + + ++ F+ LV L+ L L+ N L +P +NL L+ L
Sbjct: 117 LLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLD 176
Query: 184 LALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEF-PQ 242
L+ N ++ +P + L L LH+N++ SL + L L L + N++ P
Sbjct: 177 LSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPG 236
Query: 243 AIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLV 302
A LP+L L N ++ +P F + L + L++NPL+ + F + L L
Sbjct: 237 AFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELW 296
Query: 303 IRGASM----VQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDL 358
+ + F NL+ +L +TL+ ++S++P Q L+ L L N + L
Sbjct: 297 LNRTQLRTLPAAAFRNLSRLRYL-GVTLS-PRLSALPQGAFQGLGELQVLALHSNGLTAL 354
Query: 359 PS--FNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPIT 416
P G L ++SL+RN++ + F+ L SL + L N + + F L +T
Sbjct: 355 PDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLT 414
Query: 417 NLDVSFN 423
+ + N
Sbjct: 415 EVLLGHN 421
Score = 80.5 bits (197), Expect = 7e-15
Identities = 55/177 (31%), Positives = 95/177 (53%), Gaps = 1/177 (0%)
Query: 61 ALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTV 120
+L +S N++ LP F + L L L N L+ + + L+ L L QL+T+
Sbjct: 246 SLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTL 305
Query: 121 PSEAIRGLSALQSLRLDAN-HITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTL 179
P+ A R LS L+ L + + ++++P+ +F+GL +L+ L L N LT +P L L L
Sbjct: 306 PAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKL 365
Query: 180 QALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNN 236
+ ++L N++ ++P F NLSSL + L +N++ +L F L L + L +N+
Sbjct: 366 RQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNS 422
Score = 32.3 bits (72), Expect = 2.2
Identities = 21/83 (25%), Positives = 35/83 (42%)
Query: 360 SFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLD 419
+F+ L+ + L RN+I + ++ L L L N + I F L + L
Sbjct: 93 TFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELA 152
Query: 420 VSFNELTSFPTEGLNGLNQLKLV 442
++ N+L P L LKL+
Sbjct: 153 LNQNQLDFLPASLFTNLENLKLL 175
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 129 bits (325), Expect = 1e-29
Identities = 109/352 (30%), Positives = 161/352 (45%), Gaps = 10/352 (2%)
Query: 8 LCFLALGLLGSAGPSGAAPPL---CAAPCSCDGDRR-VDCSGKGLTAVPEGLSAFTQALD 63
LC L+L LL AAPP C A C C R V C+ + LTAVP+G+ A T+ L+
Sbjct: 5 LCVLSLPLLLLP----AAPPPAGGCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLE 60
Query: 64 ISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSE 123
+S N I L P LEEL L+ N ++ + P A + L L+VL L+ NQLK +P
Sbjct: 61 LSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPG 120
Query: 124 AIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALT 183
L L L L N + + + +F+ L LR L + DN L V + L L+ LT
Sbjct: 121 VFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELT 180
Query: 184 LALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDL-NYNNLGEFPQ 242
L ++++ + +L SL L L + I SL F L L L++ N+ L E
Sbjct: 181 LERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAA 240
Query: 243 AIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLV 302
+L L +I+ +P A L ++L NP+S V +F +L L L
Sbjct: 241 GSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELH 300
Query: 303 IRGASMVQQFPN-LTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYN 353
+ GA + P G + L L+ +S++ + L TL + N
Sbjct: 301 LAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGN 352
Score = 73.6 bits (179), Expect = 8e-13
Identities = 67/246 (27%), Positives = 107/246 (43%), Gaps = 55/246 (22%)
Query: 45 GKGLTAVPEGLSAFTQA-----LDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPK 99
G L +P G+ FT+ LD+S N + L + F++ L L++ NDL F+ +
Sbjct: 111 GNQLKLIPPGV--FTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRR 168
Query: 100 ALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLW 159
A +GL L+ LTL+ L + E++ L +L +LRL I S+ + +F L L HL
Sbjct: 169 AFAGLLALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLE 228
Query: 160 LDD------------------------NSLTEVPVHPLSNLPTLQALTLALNKISSIPDF 195
+D+ ++T VP L + L L L+ N IS++P
Sbjct: 229 IDNWPLLEEVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRG 288
Query: 196 AFTNLSSLVVLHL------------------------HNNKIRSLSQHCFDGLDNLETLD 231
+F +L L LHL NN + +L + F ++ LETL
Sbjct: 289 SFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLR 348
Query: 232 LNYNNL 237
++ N L
Sbjct: 349 VDGNPL 354
Score = 53.5 bits (127), Expect = 9e-07
Identities = 40/132 (30%), Positives = 66/132 (50%), Gaps = 8/132 (6%)
Query: 318 TVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLP--SFNGCHALEEISLQRN 375
TV ++ T +++++P+ + E ++L +LS N IR L ALEE+ L N
Sbjct: 32 TVQTRAVACTRRRLTAVPDGIPAETRLL---ELSRNRIRCLNPGDLAALPALEELDLSEN 88
Query: 376 QIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELT---SFPTEG 432
I ++ G F L LR+L L N + I F L +T LD+S N+L + +
Sbjct: 89 AIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLDYTFQD 148
Query: 433 LNGLNQLKLVGN 444
L+ L +L++ N
Sbjct: 149 LHSLRRLEVGDN 160
Score = 43.1 bits (100), Expect = 0.001
Identities = 34/125 (27%), Positives = 56/125 (44%), Gaps = 13/125 (10%)
Query: 79 NFPFLEE-------------LQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAI 125
N+P LEE L + +++ + AL L L L +N + TVP +
Sbjct: 231 NWPLLEEVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSF 290
Query: 126 RGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLA 185
R L L+ L L + V +F GL Q+R L L +N L+ + ++ TL+ L +
Sbjct: 291 RDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVD 350
Query: 186 LNKIS 190
N ++
Sbjct: 351 GNPLA 355
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 129 bits (324), Expect = 1e-29
Identities = 113/403 (28%), Positives = 174/403 (43%), Gaps = 27/403 (6%)
Query: 25 APPLCAAPCSCDGD-RRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFL 83
A P P CD + V CS + L VP + +T+ + + T L AF + P L
Sbjct: 16 ARPAQPCPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNL 75
Query: 84 EELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITS 143
++ L P A GL L+ L + + + + L++L L L+ N + +
Sbjct: 76 TKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEA 135
Query: 144 VPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSL 203
+PE F+ L L L L N L +P L L+ L LA N ++ +P+ F L+SL
Sbjct: 136 LPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSL 195
Query: 204 VVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEF-PQAIKALPSLKELGFHSNSISV 262
L L NN + L Q F L +L+ L L+ NN+ E PQ L L+ L N+I+
Sbjct: 196 QTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITH 255
Query: 263 IPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLE 322
+P F + +GN F +L + L + A + P L G
Sbjct: 256 LPLSIF----------------ASLGNLTFLSL-QWNMLRVLPAGLFAHTPCLVG----- 293
Query: 323 SLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPS--FNGCHALEEISLQRNQIYQI 380
L+LT ++ ++ LR+L LSYN I LP+ F L ++ L N + +
Sbjct: 294 -LSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTAL 352
Query: 381 KEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFN 423
FQ L L +L LS+N + + F T + NL + N
Sbjct: 353 HPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGN 395
Score = 110 bits (276), Expect = 5e-24
Identities = 88/299 (29%), Positives = 142/299 (47%), Gaps = 26/299 (8%)
Query: 147 DSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVL 206
D+F GL +L L + +S + + SNL +L LTL N + ++P+ F +L++L L
Sbjct: 91 DAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESL 150
Query: 207 HLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAI-KALPSLKELGFHSNSISVIPD 265
HL N++++L + F L +L+TL+L N L + P+ + L SL+ L +N++S +P
Sbjct: 151 HLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQ 210
Query: 266 GAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLT 325
G F L+ + L N +S + F L LE L
Sbjct: 211 GVFGKLGSLQELFLDSNNISELPPQVFSQL-----------------------FCLERLW 247
Query: 326 LTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHA--LEEISLQRNQIYQIKEG 383
L I+ +P ++ L L L +N +R LP+ H L +SL NQ+ + EG
Sbjct: 248 LQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEG 307
Query: 384 TFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLKLV 442
TF L +LR L LS N I + + F L + L + N LT+ L++L+L+
Sbjct: 308 TFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELL 366
Score = 63.5 bits (153), Expect = 9e-10
Identities = 49/194 (25%), Positives = 87/194 (44%), Gaps = 6/194 (3%)
Query: 250 LKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMV 309
++E+ ++ +P D P + I + + + AF + +L +V +
Sbjct: 30 VQEVFCSDEELATVP---LDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVVFLNTQLC 86
Query: 310 QQFPNLTGTV-HLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPS--FNGCHA 366
Q P+ G + LE L +TG+ ++ N+ L L L++N + LP F A
Sbjct: 87 QFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAA 146
Query: 367 LEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELT 426
LE + LQ NQ+ + FQ L L+ L+L++NL+ ++ F L + L +S N L+
Sbjct: 147 LESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALS 206
Query: 427 SFPTEGLNGLNQLK 440
P L L+
Sbjct: 207 GLPQGVFGKLGSLQ 220
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 125 bits (315), Expect = 1e-28
Identities = 115/419 (27%), Positives = 197/419 (47%), Gaps = 41/419 (9%)
Query: 33 CSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISM--NNITQLPEDAFKNFPFLEELQLAG 90
C + R+D S + + +P + TQ ++ + N + LP + L L L+
Sbjct: 97 CREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEV-GCLVNLMTLALSE 155
Query: 91 NDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFE 150
N L+ + P +L LK+L++L L++N+L+ +PS R L +L +L L N IT+V +D +
Sbjct: 156 NSLTSL-PDSLDNLKKLRMLDLRHNKLREIPSVVYR-LDSLTTLYLRFNRITTVEKD-IK 212
Query: 151 GLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHN 210
L +L L + +N + ++P + L L L +A N++ +P N + + L L +
Sbjct: 213 NLSKLSMLSIRENKIKQLPAE-IGELCNLITLDVAHNQLEHLPK-EIGNCTQITNLDLQH 270
Query: 211 NKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDG 270
N++ L L +L L L YN L P+++ +L+EL +N+IS +P+
Sbjct: 271 NELLDLPD-TIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSS 329
Query: 271 NPLLRTIHLYDN--PLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTG 328
L ++ L N L VG P+ T++ SL +
Sbjct: 330 LVKLNSLTLARNCFQLYPVGG-----------------------PSQFSTIY--SLNMEH 364
Query: 329 TKISSIPNNLCQEQKMLRTLDLSYNNIRDLP-SFNGCHALEEISLQRNQIYQIKEGTFQG 387
+I+ IP + K+L L++ N + LP F ++ E++L NQ+ +I E G
Sbjct: 365 NRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDV-SG 423
Query: 388 LISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTE--GLNGLNQLKLVGN 444
L+SL +L LS NL+ ++ L + LD+ N+L S P E L L +L L N
Sbjct: 424 LVSLEVLILSNNLLKKL-PHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNN 481
Score = 93.2 bits (230), Expect = 1e-18
Identities = 87/294 (29%), Positives = 142/294 (48%), Gaps = 12/294 (4%)
Query: 62 LDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVP 121
LD++ N + LP++ N + L L N+L + P + L L L L+ N+L +P
Sbjct: 243 LDVAHNQLEHLPKE-IGNCTQITNLDLQHNELLDL-PDTIGNLSSLSRLGLRYNRLSAIP 300
Query: 122 SEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQA 181
++ SAL+ L L+ N+I+++PE LV+L L L N PV S T+ +
Sbjct: 301 -RSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYS 359
Query: 182 LTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFP 241
L + N+I+ IP F+ L L++ +N++ SL F ++ L+L N L + P
Sbjct: 360 LNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLD-FGTWTSMVELNLATNQLTKIP 418
Query: 242 QAIKALPSLKELGFHSNSISVIPDGAFDGN-PLLRTIHLYDNPLSFVGNSAFHNLSDLHS 300
+ + L SL+ L +N + +P G GN LR + L +N L + N + L DL
Sbjct: 419 EDVSGLVSLEVLILSNNLLKKLPHGL--GNLRKLRELDLEENKLESLPNEIAY-LKDLQK 475
Query: 301 LVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNN 354
LV+ + + P G HL +LT G ++ +L +E L L+ Y N
Sbjct: 476 LVLTN-NQLTTLPR--GIGHLTNLTHLGLG-ENLLTHLPEEIGTLENLEELYLN 525
Score = 83.2 bits (204), Expect = 1e-15
Identities = 70/240 (29%), Positives = 110/240 (45%), Gaps = 11/240 (4%)
Query: 48 LTAVPEGLSAFT--QALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLK 105
L+A+P L+ + + L++ NNI+ LPE + L L LA N S
Sbjct: 296 LSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFS 355
Query: 106 ELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSL 165
+ L +++N++ +P L L + N +TS+P D F + L L N L
Sbjct: 356 TIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLD-FGTWTSMVELNLATNQL 414
Query: 166 TEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLD 225
T++P +S L +L+ L L+ N + +P NL L L L NK+ SL L
Sbjct: 415 TKIP-EDVSGLVSLEVLILSNNLLKKLP-HGLGNLRKLRELDLEENKLESLPNE-IAYLK 471
Query: 226 NLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPD--GAFDGNPLLRTIHLYDNP 283
+L+ L L N L P+ I L +L LG N ++ +P+ G + L ++L DNP
Sbjct: 472 DLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLEN---LEELYLNDNP 528
>gi|19743846 decorin isoform a preproprotein [Homo sapiens]
Length = 359
Score = 121 bits (303), Expect = 4e-27
Identities = 88/269 (32%), Positives = 134/269 (49%), Gaps = 11/269 (4%)
Query: 27 PLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEEL 86
P+C C C R V CS GL VP+ L T LD+ N IT++ + FKN L L
Sbjct: 52 PVCPFRCQCHL-RVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHAL 110
Query: 87 QLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPE 146
L N +S + P A + L +L+ L L NQLK +P + + LQ LR N IT V +
Sbjct: 111 ILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPK---TLQELRAHENEITKVRK 167
Query: 147 DSFEGLVQLRHLWLDDNSLTEVPVH--PLSNLPTLQALTLALNKISSIPDFAFTNLSSLV 204
+F GL Q+ + L N L + + L + +A I+SIP SL
Sbjct: 168 VTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGL---PPSLT 224
Query: 205 VLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQ-AIKALPSLKELGFHSNSISVI 263
LHL NKI + GL+NL L L++N++ ++ P L+EL +N ++ +
Sbjct: 225 ELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRV 284
Query: 264 PDGAFDGNPLLRTIHLYDNPLSFVGNSAF 292
P G + + ++ ++L++N +S VG+S F
Sbjct: 285 PGGLAE-HKYIQVVYLHNNNISVVGSSDF 312
Score = 74.3 bits (181), Expect = 5e-13
Identities = 82/287 (28%), Positives = 112/287 (39%), Gaps = 55/287 (19%)
Query: 145 PEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLV 204
P F LR + D L +VP P L L NKI+ I D F NL +L
Sbjct: 52 PVCPFRCQCHLRVVQCSDLGLDKVPK---DLPPDTTLLDLQNNKITEIKDGDFKNLKNLH 108
Query: 205 VLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIP 264
L L NNKI +S F L LE L L+ N L E P+ K +L+EL H N I+ +
Sbjct: 109 ALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPE--KMPKTLQELRAHENEITKVR 166
Query: 265 DGAFDGNPLLRTIHLYDNPLSFVG--NSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLE 322
F+G + I L NPL G N AF G L
Sbjct: 167 KVTFNGLNQMIVIELGTNPLKSSGIENGAFQ-----------------------GMKKLS 203
Query: 323 SLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQIKE 382
+ + T I+SIP L +L E+ L N+I ++
Sbjct: 204 YIRIADTNITSIPQGLPP-------------------------SLTELHLDGNKISRVDA 238
Query: 383 GTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFP 429
+ +GL +L L LS N I + + + A + L + N+LT P
Sbjct: 239 ASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVP 285
Score = 44.3 bits (103), Expect = 5e-04
Identities = 34/125 (27%), Positives = 56/125 (44%), Gaps = 8/125 (6%)
Query: 320 HLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPS--FNGCHALEEISLQRNQI 377
HL + + + +P +L + +L DL N I ++ F L + L N+I
Sbjct: 61 HLRVVQCSDLGLDKVPKDLPPDTTLL---DLQNNKITEIKDGDFKNLKNLHALILVNNKI 117
Query: 378 YQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLN 437
++ G F L+ L L LS+N + E+ + TL L NE+T NGLN
Sbjct: 118 SKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTL---QELRAHENEITKVRKVTFNGLN 174
Query: 438 QLKLV 442
Q+ ++
Sbjct: 175 QMIVI 179
>gi|4503271 decorin isoform a preproprotein [Homo sapiens]
Length = 359
Score = 121 bits (303), Expect = 4e-27
Identities = 88/269 (32%), Positives = 134/269 (49%), Gaps = 11/269 (4%)
Query: 27 PLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEEL 86
P+C C C R V CS GL VP+ L T LD+ N IT++ + FKN L L
Sbjct: 52 PVCPFRCQCHL-RVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHAL 110
Query: 87 QLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPE 146
L N +S + P A + L +L+ L L NQLK +P + + LQ LR N IT V +
Sbjct: 111 ILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPK---TLQELRAHENEITKVRK 167
Query: 147 DSFEGLVQLRHLWLDDNSLTEVPVH--PLSNLPTLQALTLALNKISSIPDFAFTNLSSLV 204
+F GL Q+ + L N L + + L + +A I+SIP SL
Sbjct: 168 VTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGL---PPSLT 224
Query: 205 VLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQ-AIKALPSLKELGFHSNSISVI 263
LHL NKI + GL+NL L L++N++ ++ P L+EL +N ++ +
Sbjct: 225 ELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRV 284
Query: 264 PDGAFDGNPLLRTIHLYDNPLSFVGNSAF 292
P G + + ++ ++L++N +S VG+S F
Sbjct: 285 PGGLAE-HKYIQVVYLHNNNISVVGSSDF 312
Score = 74.3 bits (181), Expect = 5e-13
Identities = 82/287 (28%), Positives = 112/287 (39%), Gaps = 55/287 (19%)
Query: 145 PEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLV 204
P F LR + D L +VP P L L NKI+ I D F NL +L
Sbjct: 52 PVCPFRCQCHLRVVQCSDLGLDKVPK---DLPPDTTLLDLQNNKITEIKDGDFKNLKNLH 108
Query: 205 VLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIP 264
L L NNKI +S F L LE L L+ N L E P+ K +L+EL H N I+ +
Sbjct: 109 ALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPE--KMPKTLQELRAHENEITKVR 166
Query: 265 DGAFDGNPLLRTIHLYDNPLSFVG--NSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLE 322
F+G + I L NPL G N AF G L
Sbjct: 167 KVTFNGLNQMIVIELGTNPLKSSGIENGAFQ-----------------------GMKKLS 203
Query: 323 SLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQIKE 382
+ + T I+SIP L +L E+ L N+I ++
Sbjct: 204 YIRIADTNITSIPQGLPP-------------------------SLTELHLDGNKISRVDA 238
Query: 383 GTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFP 429
+ +GL +L L LS N I + + + A + L + N+LT P
Sbjct: 239 ASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVP 285
Score = 44.3 bits (103), Expect = 5e-04
Identities = 34/125 (27%), Positives = 56/125 (44%), Gaps = 8/125 (6%)
Query: 320 HLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPS--FNGCHALEEISLQRNQI 377
HL + + + +P +L + +L DL N I ++ F L + L N+I
Sbjct: 61 HLRVVQCSDLGLDKVPKDLPPDTTLL---DLQNNKITEIKDGDFKNLKNLHALILVNNKI 117
Query: 378 YQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLN 437
++ G F L+ L L LS+N + E+ + TL L NE+T NGLN
Sbjct: 118 SKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTL---QELRAHENEITKVRKVTFNGLN 174
Query: 438 QLKLV 442
Q+ ++
Sbjct: 175 QMIVI 179
>gi|12007646 nyctalopin precursor [Homo sapiens]
Length = 481
Score = 120 bits (301), Expect = 6e-27
Identities = 103/308 (33%), Positives = 134/308 (43%), Gaps = 6/308 (1%)
Query: 3 GPLGLLCFLALGLLGSAGPSGAAPPLCAAPCSCDGDRR---VDCSGKGLTAVPEGLSAFT 59
G L LL + L SA GA C A C+C R V C GL VP L
Sbjct: 5 GMLVLLLHAVVLGLPSAWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAELPCEA 64
Query: 60 QALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTL-QNNQLK 118
++D+ N + L E AF P L L L N+LSFI P A GL L L L N L+
Sbjct: 65 VSIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLR 124
Query: 119 TVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPT 178
+ + LS L+ L L A + SVPE L LR L DN VP L L
Sbjct: 125 YLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVP-GALRGLAN 183
Query: 179 LQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLG 238
L L +I ++ + L L L L N++R++ F LE L LN N L
Sbjct: 184 LTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLA 243
Query: 239 EFP-QAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSD 297
E P A + L L+ L N++ + F L ++L N ++FV AF NLS
Sbjct: 244 ELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSG 303
Query: 298 LHSLVIRG 305
L +L + G
Sbjct: 304 LLALHLNG 311
Score = 84.3 bits (207), Expect = 5e-16
Identities = 59/185 (31%), Positives = 95/185 (51%), Gaps = 2/185 (1%)
Query: 39 RRVDCSGKGLTAVPEGLSAFTQALD--ISMNNITQLPEDAFKNFPFLEELQLAGNDLSFI 96
RR+D + L +VPE L A AL + +N+ + A + L L + +
Sbjct: 138 RRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRGLANLTHAHLERGRIEAV 197
Query: 97 HPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLR 156
+L GL+ L+ L+LQ N+++ V + A L+ L L+ N + +P D+F GL +LR
Sbjct: 198 ASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLR 257
Query: 157 HLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSL 216
L L N+L V ++L L+ L L N I+ + + AF NLS L+ LHL+ N++ L
Sbjct: 258 TLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRLTVL 317
Query: 217 SQHCF 221
+ F
Sbjct: 318 AWVAF 322
Score = 81.3 bits (199), Expect = 4e-15
Identities = 78/271 (28%), Positives = 113/271 (41%), Gaps = 28/271 (10%)
Query: 160 LDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHL-HNNKIRSLSQ 218
LD N L + LP+L+ L+L N +S I AF L L L L HN +R L
Sbjct: 69 LDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHA 128
Query: 219 HCFDGLDNLETLDLNYNNLGEFPQAIKA-LPSLKELGFHSNSISVIPDGAFDGNPLLRTI 277
F L L LDL L P+ + A LP+L+EL N +P GA G L
Sbjct: 129 RTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVP-GALRGLANLTHA 187
Query: 278 HLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNN 337
HL + V +S+ L G L SL+L ++ ++
Sbjct: 188 HLERGRIEAVASSS-----------------------LQGLRRLRSLSLQANRVRAVHAG 224
Query: 338 LCQEQKMLRTLDLSYNNIRDLPS--FNGCHALEEISLQRNQIYQIKEGTFQGLISLRILD 395
+ +L L L+ N + +LP+ F G L ++L N + ++ F L L +L
Sbjct: 225 AFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLY 284
Query: 396 LSRNLIHEIHSRAFATLGPITNLDVSFNELT 426
L RN I + AF L + L ++ N LT
Sbjct: 285 LDRNSIAFVEEGAFQNLSGLLALHLNGNRLT 315
Score = 78.2 bits (191), Expect = 3e-14
Identities = 72/245 (29%), Positives = 105/245 (42%), Gaps = 33/245 (13%)
Query: 229 TLDLNYNNL---GEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLS 285
++DL+ N L GE +A LPSL+ L N++S I GAF G P L + L N
Sbjct: 66 SIDLDRNGLRFLGE--RAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNG-- 121
Query: 286 FVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKML 345
+L LH+ S L L L ++ S+P L E L
Sbjct: 122 --------DLRYLHARTFAALS------------RLRRLDLAACRLFSVPERLLAELPAL 161
Query: 346 RTLDLSYNNIRDLP-SFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEI 404
R L N R +P + G L L+R +I + + QGL LR L L N + +
Sbjct: 162 RELAAFDNLFRRVPGALRGLANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAV 221
Query: 405 HSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLK---LVGNFKLKEALAAKDFVNLRS 461
H+ AF G + +L ++ N L P + GL +L+ L GN + +A F +L
Sbjct: 222 HAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGN--ALDRVARAWFADLAE 279
Query: 462 LSVPY 466
L + Y
Sbjct: 280 LELLY 284
Score = 48.5 bits (114), Expect = 3e-05
Identities = 32/97 (32%), Positives = 48/97 (49%)
Query: 67 NNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIR 126
N + +LP DAF+ L L L GN L + + L EL++L L N + V A +
Sbjct: 240 NLLAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQ 299
Query: 127 GLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDN 163
LS L +L L+ N +T + +F+ L L+L N
Sbjct: 300 NLSGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRN 336
>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
Length = 811
Score = 120 bits (300), Expect = 8e-27
Identities = 112/396 (28%), Positives = 165/396 (41%), Gaps = 52/396 (13%)
Query: 11 LALGLLGSAGPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPE--GLSAFTQALDISM-- 66
L L + G A P+C C C + + C+ +GL VP+ L + L S+
Sbjct: 9 LLLVVCGCLALPPLAEPVCPERCDCQHPQHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGG 68
Query: 67 NNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIR 126
N IT + F L L L N + +HPK L L+ L L NN L+ + +
Sbjct: 69 NFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLA 128
Query: 127 GLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLAL 186
L L+ L + N I+ + SFEGL L L LD N+L
Sbjct: 129 PLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNAL--------------------- 167
Query: 187 NKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKA 246
++PD F L +L+ LHL +N+IR L ++ F L L L+L+ N L
Sbjct: 168 ---GALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANEL--------- 215
Query: 247 LPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGA 306
PSL+ H+ + + + L ++ L N L +G F +L L L +RG
Sbjct: 216 QPSLR----HAATFAPLRS--------LSSLILSANNLQHLGPRIFQHLPRLGLLSLRGN 263
Query: 307 SMVQQFPN-LTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDL--PSFNG 363
+ P G L L L G ++S +P L + L LDLS N + L +F
Sbjct: 264 QLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGH 323
Query: 364 CHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRN 399
L E+SL+ N + + F +L LDL N
Sbjct: 324 LGRLRELSLRNNALSALSGDIFAASPALYRLDLDGN 359
Score = 96.7 bits (239), Expect = 9e-20
Identities = 91/324 (28%), Positives = 143/324 (44%), Gaps = 7/324 (2%)
Query: 110 LTLQNNQLKTVP-SEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEV 168
L N L+ VP + ++ + + L N IT++ F L QLR L L N + +
Sbjct: 39 LLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSL 98
Query: 169 PVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLE 228
L L+ L L N + ++ L L +L+ + N+I LS+ F+GL++L
Sbjct: 99 HPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLV 158
Query: 229 TLDLNYNNLGEFPQAIKA-LPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPL--S 285
L L+ N LG P A+ A L +L L SN I + AF LR ++L N L S
Sbjct: 159 KLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPS 218
Query: 286 FVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTV-HLESLTLTGTKISSIPNNLCQEQKM 344
+ F L L SL++ ++ P + + L L+L G +++ + +
Sbjct: 219 LRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEA 278
Query: 345 LRTLDLSYNNIRDLPS--FNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIH 402
LR L L N + LP+ H+LE + L N++ + TF L LR L L N +
Sbjct: 279 LRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALS 338
Query: 403 EIHSRAFATLGPITNLDVSFNELT 426
+ FA + LD+ N T
Sbjct: 339 ALSGDIFAASPALYRLDLDGNGWT 362
Score = 81.6 bits (200), Expect = 3e-15
Identities = 78/284 (27%), Positives = 121/284 (42%), Gaps = 24/284 (8%)
Query: 160 LDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQH 219
L N +T + L L+ L L N+I S+ F LS L L+L NN +++L+
Sbjct: 66 LGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPG 125
Query: 220 CFDGLDNLETLDLNYNNLGEFPQ-AIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIH 278
L L L N N + + + + L SL +L N++ +PD F L +H
Sbjct: 126 TLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLH 185
Query: 279 LYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNL 338
L N + F+G +AF L L +F NL+ SL T
Sbjct: 186 LESNRIRFLGKNAFAQLGKL------------RFLNLSANELQPSLRHAAT--------- 224
Query: 339 CQEQKMLRTLDLSYNNIRDLPS--FNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDL 396
+ L +L LS NN++ L F L +SL+ NQ+ + F GL +LR L L
Sbjct: 225 FAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRL 284
Query: 397 SRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLK 440
N + ++ + L + LD+S NEL++ L +L+
Sbjct: 285 EGNRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLR 328
Score = 50.4 bits (119), Expect = 8e-06
Identities = 57/213 (26%), Positives = 89/213 (41%), Gaps = 17/213 (7%)
Query: 292 FHNLSDLHSLVIRGASMVQQFPNLTGTV-HLESLTLTGTKISSIPNNLCQEQKMLRTLDL 350
FH L L L ++ + P + LE L L + ++ + LR L
Sbjct: 79 FHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYA 138
Query: 351 SYNNIRDLP--SFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRA 408
+ N I L SF G +L ++ L N + + + F L +L L L N I + A
Sbjct: 139 NGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNA 198
Query: 409 FATLGPITNLDVSFNEL--------TSFPTEGLNGL----NQLKLVGNFKLKEALAAKDF 456
FA LG + L++S NEL T P L+ L N L+ +G ++ + L
Sbjct: 199 FAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGP-RIFQHLPRLGL 257
Query: 457 VNLRSLSVPYAYQCCAFWGCDSYANLNTEDNSL 489
++LR + + AFWG ++ L E N L
Sbjct: 258 LSLRGNQLTHLAP-EAFWGLEALRELRLEGNRL 289
Score = 48.9 bits (115), Expect = 2e-05
Identities = 34/105 (32%), Positives = 47/105 (44%)
Query: 62 LDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVP 121
L + N +T L +AF L EL+L GN LS + L L L+ L L N+L +
Sbjct: 258 LSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALH 317
Query: 122 SEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLT 166
L L+ L L N ++++ D F L L LD N T
Sbjct: 318 PATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGNGWT 362
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,362,705
Number of Sequences: 37866
Number of extensions: 1594716
Number of successful extensions: 9052
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 248
Number of HSP's successfully gapped in prelim test: 170
Number of HSP's that attempted gapping in prelim test: 4441
Number of HSP's gapped (non-prelim): 1713
length of query: 951
length of database: 18,247,518
effective HSP length: 112
effective length of query: 839
effective length of database: 14,006,526
effective search space: 11751475314
effective search space used: 11751475314
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.