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Search of human proteins with 157502203
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157502203 ATP-binding cassette, sub-family C, member 4
isoform 2 [Homo sapiens]
(859 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157502203 ATP-binding cassette, sub-family C, member 4 isofor... 1699 0.0
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor... 1670 0.0
gi|134142335 ATP-binding cassette, sub-family C, member 1 isofor... 447 e-125
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor... 447 e-125
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member... 443 e-124
gi|89111135 ATP-binding cassette protein C12 [Homo sapiens] 439 e-123
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ... 438 e-122
gi|90421313 cystic fibrosis transmembrane conductance regulator ... 414 e-115
gi|21729876 ATP-binding cassette, sub-family C, member 11 isofor... 391 e-108
gi|21729873 ATP-binding cassette, sub-family C, member 11 isofor... 391 e-108
gi|15149474 ATP-binding cassette, sub-family C, member 11 isofor... 391 e-108
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ... 370 e-102
gi|110832839 ATP-binding cassette, sub-family C, member 9 isofor... 365 e-100
gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor... 362 1e-99
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens] 362 1e-99
gi|110832835 ATP-binding cassette, sub-family C, member 9 isofor... 355 1e-97
gi|110832837 ATP-binding cassette, sub-family C, member 9 isofor... 355 1e-97
gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor... 340 3e-93
gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo ... 332 7e-91
gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor... 322 9e-88
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform... 281 2e-75
gi|134142342 ATP-binding cassette, sub-family C, member 1 isofor... 240 4e-63
gi|221316556 ATP-binding cassette, sub-family C, member 3 isofor... 184 4e-46
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 134 4e-31
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 129 9e-30
gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo ... 129 9e-30
gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member ... 128 2e-29
gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member... 128 2e-29
gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo sa... 122 1e-27
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 121 2e-27
>gi|157502203 ATP-binding cassette, sub-family C, member 4 isoform 2
[Homo sapiens]
Length = 859
Score = 1699 bits (4401), Expect = 0.0
Identities = 859/859 (100%), Positives = 859/859 (100%)
Query: 1 MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEEL 60
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEEL
Sbjct: 1 MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEEL 60
Query: 61 QGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYF 120
QGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYF
Sbjct: 61 QGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYF 120
Query: 121 ENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALR 180
ENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALR
Sbjct: 121 ENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALR 180
Query: 181 LSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAG 240
LSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAG
Sbjct: 181 LSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAG 240
Query: 241 MAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLIT 300
MAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLIT
Sbjct: 241 MAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLIT 300
Query: 301 NLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGA 360
NLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGA
Sbjct: 301 NLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGA 360
Query: 361 VRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWD 420
VRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWD
Sbjct: 361 VRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWD 420
Query: 421 KASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQ 480
KASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQ
Sbjct: 421 KASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQ 480
Query: 481 QPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQK 540
QPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQK
Sbjct: 481 QPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQK 540
Query: 541 ARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAA 600
ARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAA
Sbjct: 541 ARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAA 600
Query: 601 SQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVW 660
SQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVW
Sbjct: 601 SQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVW 660
Query: 661 SQQSSRPSLKDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILL 720
SQQSSRPSLKDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILL
Sbjct: 661 SQQSSRPSLKDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILL 720
Query: 721 NTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGI 780
NTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGI
Sbjct: 721 NTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGI 780
Query: 781 ARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTF 840
ARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTF
Sbjct: 781 ARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTF 840
Query: 841 LDFIQRWDLAVLSWLVSNS 859
LDFIQRWDLAVLSWLVSNS
Sbjct: 841 LDFIQRWDLAVLSWLVSNS 859
>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
[Homo sapiens]
Length = 1325
Score = 1670 bits (4326), Expect = 0.0
Identities = 845/845 (100%), Positives = 845/845 (100%)
Query: 1 MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEEL 60
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEEL
Sbjct: 1 MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEEL 60
Query: 61 QGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYF 120
QGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYF
Sbjct: 61 QGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYF 120
Query: 121 ENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALR 180
ENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALR
Sbjct: 121 ENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALR 180
Query: 181 LSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAG 240
LSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAG
Sbjct: 181 LSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAG 240
Query: 241 MAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLIT 300
MAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLIT
Sbjct: 241 MAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLIT 300
Query: 301 NLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGA 360
NLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGA
Sbjct: 301 NLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGA 360
Query: 361 VRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWD 420
VRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWD
Sbjct: 361 VRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWD 420
Query: 421 KASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQ 480
KASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQ
Sbjct: 421 KASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQ 480
Query: 481 QPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQK 540
QPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQK
Sbjct: 481 QPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQK 540
Query: 541 ARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAA 600
ARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAA
Sbjct: 541 ARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAA 600
Query: 601 SQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVW 660
SQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVW
Sbjct: 601 SQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVW 660
Query: 661 SQQSSRPSLKDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILL 720
SQQSSRPSLKDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILL
Sbjct: 661 SQQSSRPSLKDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILL 720
Query: 721 NTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGI 780
NTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGI
Sbjct: 721 NTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGI 780
Query: 781 ARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTF 840
ARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTF
Sbjct: 781 ARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTF 840
Query: 841 LDFIQ 845
LDFIQ
Sbjct: 841 LDFIQ 845
Score = 90.1 bits (222), Expect = 8e-18
Identities = 118/562 (20%), Positives = 236/562 (41%), Gaps = 57/562 (10%)
Query: 88 YWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVA------------LNTAY 135
+W ++ L + + A V+Q +L +Y+ N M +V LN
Sbjct: 710 HWIVFIFLILLNTAAQVAYVLQDWWL----SYWANKQSMLNVTVNGGGNVTEKLDLNWYL 765
Query: 136 AYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIV 195
+ LT T++ I L ++V + + + ++ L+ + + G+I+
Sbjct: 766 GIYSGLTVATVLFGIARSLLVFYVLVNSSQ---TLHNKMFESILKAPVLFFDRNPIGRIL 822
Query: 196 NLLSNDVNKFDQVT--VFLHF----LWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLP 249
N S D+ D + FL F L + ++AV + W+ I + L II +
Sbjct: 823 NRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLG-----IIFIF 877
Query: 250 LQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISK 309
L+ F + ++ +T ++ + G+ I+ Y E+ L + +
Sbjct: 878 LRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELF------DAHQ 931
Query: 310 ILRSSC-LRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVA-VTLYGAVRLTVTL 367
L S + + +F+ + F V GS+I A + V L + LT+
Sbjct: 932 DLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMG 991
Query: 368 FFPSAIERVSEA---IVSIRRIQTFLLLDEISQ---RNRQLPSDGKKMVHVQDFTAFWDK 421
F + + +E ++S+ R+ + L++ + + R P+ + V + D F
Sbjct: 992 MFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYS 1051
Query: 422 ASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAV--LGE----------LAPSHGLV 469
L+ L+ ++ E + +VG GAGKSSL+SA+ L E L GL
Sbjct: 1052 PGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLH 1111
Query: 470 SVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIG 529
+ +++ + Q+P +F+GT+R N+ ++ E ++ LK+ ++ L T +
Sbjct: 1112 DLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELA 1171
Query: 530 DRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITIL 589
+ G+ S GQ+ V LARA+ + I ++D+ + VD L + I + +
Sbjct: 1172 ESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTD-ELIQKKIREKFAHCTVLT 1230
Query: 590 VTHQLQYLKAASQILILKDGKM 611
+ H+L + + +I++L G++
Sbjct: 1231 IAHRLNTIIDSDKIMVLDSGRL 1252
>gi|134142335 ATP-binding cassette, sub-family C, member 1 isoform 5
[Homo sapiens]
Length = 1466
Score = 447 bits (1149), Expect = e-125
Identities = 291/914 (31%), Positives = 472/914 (51%), Gaps = 100/914 (10%)
Query: 3 PVYQEV----KPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGE 58
P++ E P P A+ SR+ FWW+ L G+++ LE D++S+ ED S+ +
Sbjct: 196 PLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVP 255
Query: 59 ELQGFWDKEVLRAENDAQK------------------------------------PSLTR 82
L W KE + K PSL +
Sbjct: 256 VLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFK 315
Query: 83 AIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLT 142
+ K + +L+ F I + P L +I + D+ A + + TVL
Sbjct: 316 VLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVN-----DTKAPDWQGYFYTVLL 370
Query: 143 FCTLIL-AILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSND 201
F T L ++ H YF+ +GMR++ A+ +YRKAL ++N A +T G+IVNL+S D
Sbjct: 371 FVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVD 430
Query: 202 VNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSL 261
+F + +++ +W+ PLQ I LLW+ +G S LAG+AV+++++P+ + +
Sbjct: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTY 490
Query: 262 RSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNL 321
+ D RI+ MNE++ GI+++K+YAWE +F + + +R++E+ + +S+ L +
Sbjct: 491 QVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGT 550
Query: 322 ASFFSASKIIVFVTFTTYVLL--GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEA 379
++ ++ TF YV + +++ A FV++ L+ +R + + P I + +A
Sbjct: 551 FTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNIL-PMVISSIVQA 609
Query: 380 IVSIRRIQTFLLLDEIS----QRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTV 435
VS++R++ FL +E+ +R G + V++ T W + S+ PTL G++F++
Sbjct: 610 SVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWAR-SDPPTLNGITFSI 668
Query: 436 RPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILF 495
G L+AVVG VG GKSSLLSA+L E+ G V++ G +AYV QQ W+ + +LR NILF
Sbjct: 669 PEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILF 728
Query: 496 GKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADI 555
G + E+ Y VI+ACAL DL++L GD T IG++G LSGGQK RV+LARAVY +ADI
Sbjct: 729 GCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADI 788
Query: 556 YLLDDPLSAVDAEVSRHLFELCICQ--ILHEKITILVTHQLQYLKAASQILILKDGKMVQ 613
YL DDPLSAVDA V +H+FE I +L K ILVTH + YL I+++ GK+ +
Sbjct: 789 YLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISE 848
Query: 614 KGTYTEFLKSGIDFGSLLK-----KDNEESEQPPVPG-------TPTLRN---------- 651
G+Y E L F L+ + +++E+ V G + N
Sbjct: 849 MGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGK 908
Query: 652 ---RTFSESSVWSQQSSRPSLKDGALESQDT--ENVPVTLSEENRSEGKVGFQAYKNYFR 706
R S SS +S SR L+ + E + + G+V Y +Y +
Sbjct: 909 QLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMK 968
Query: 707 AGAHWIVF--IFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTE-KLDLNW 763
A +I F IFL + N V+ + ++WLS W + + VNG T+ +L +
Sbjct: 969 AIGLFISFLSIFLFMCN---HVSALASNYWLSLWTD-----DPIVNGTQEHTKVRLSVYG 1020
Query: 764 YLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILN 823
LGI G+ V FG + ++ + +L +S+ LH + SIL++P+ FF+R P G ++N
Sbjct: 1021 ALGISQGIAV----FGYSMAVSIGGIL--ASRCLHVDLLHSILRSPMSFFERTPSGNLVN 1074
Query: 824 RFSKDIGHLDDLLP 837
RFSK++ +D ++P
Sbjct: 1075 RFSKELDTVDSMIP 1088
Score = 50.8 bits (120), Expect = 5e-06
Identities = 78/379 (20%), Positives = 151/379 (39%), Gaps = 31/379 (8%)
Query: 166 LRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPL-QAIA 224
L V + H I R + +T +G +VN S +++ D + + ++ G L I
Sbjct: 1048 LHVDLLHSILRSPMSFFE----RTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIG 1103
Query: 225 VTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIR 284
++ + I+ + + +I +Q + L+ + NE + G+
Sbjct: 1104 ACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVS 1163
Query: 285 IIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSA-SKIIVFVTFTTYVLLG 343
+I+ + ++ F + ++L+ E K S + LA IV V+
Sbjct: 1164 VIRAFEEQERFIHQ-SDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISR 1222
Query: 344 SVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEA---IVSIRRIQTFLLLDEIS--QR 398
++A V ++V+ L VT + + SE IV++ R++ + ++ + Q
Sbjct: 1223 HSLSAGLVGLSVSY----SLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQI 1278
Query: 399 NRQLPSDGKKMVHVQDFTAFWDKASETP--TLQGLSFTVRPGELLAVVGPVGAGKSSLLS 456
P V +F + + E L+ ++ T+ GE + +VG GAGKSSL
Sbjct: 1279 QETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTL 1338
Query: 457 AVLGELAPSHGLVSVHG-------------RIAYVSQQPWVFSGTLRSNILFGKKYEKER 503
+ + G + + G +I + Q P +FSG+LR N+ +Y E
Sbjct: 1339 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEE 1398
Query: 504 YEKVIKACALKKDLQLLED 522
++ LK + L D
Sbjct: 1399 VWTSLELAHLKDFVSALPD 1417
>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
[Homo sapiens]
Length = 1531
Score = 447 bits (1149), Expect = e-125
Identities = 291/914 (31%), Positives = 472/914 (51%), Gaps = 100/914 (10%)
Query: 3 PVYQEV----KPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGE 58
P++ E P P A+ SR+ FWW+ L G+++ LE D++S+ ED S+ +
Sbjct: 196 PLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVP 255
Query: 59 ELQGFWDKEVLRAENDAQK------------------------------------PSLTR 82
L W KE + K PSL +
Sbjct: 256 VLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFK 315
Query: 83 AIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLT 142
+ K + +L+ F I + P L +I + D+ A + + TVL
Sbjct: 316 VLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVN-----DTKAPDWQGYFYTVLL 370
Query: 143 FCTLIL-AILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSND 201
F T L ++ H YF+ +GMR++ A+ +YRKAL ++N A +T G+IVNL+S D
Sbjct: 371 FVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVD 430
Query: 202 VNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSL 261
+F + +++ +W+ PLQ I LLW+ +G S LAG+AV+++++P+ + +
Sbjct: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTY 490
Query: 262 RSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNL 321
+ D RI+ MNE++ GI+++K+YAWE +F + + +R++E+ + +S+ L +
Sbjct: 491 QVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGT 550
Query: 322 ASFFSASKIIVFVTFTTYVLL--GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEA 379
++ ++ TF YV + +++ A FV++ L+ +R + + P I + +A
Sbjct: 551 FTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNIL-PMVISSIVQA 609
Query: 380 IVSIRRIQTFLLLDEIS----QRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTV 435
VS++R++ FL +E+ +R G + V++ T W + S+ PTL G++F++
Sbjct: 610 SVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWAR-SDPPTLNGITFSI 668
Query: 436 RPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILF 495
G L+AVVG VG GKSSLLSA+L E+ G V++ G +AYV QQ W+ + +LR NILF
Sbjct: 669 PEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILF 728
Query: 496 GKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADI 555
G + E+ Y VI+ACAL DL++L GD T IG++G LSGGQK RV+LARAVY +ADI
Sbjct: 729 GCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADI 788
Query: 556 YLLDDPLSAVDAEVSRHLFELCICQ--ILHEKITILVTHQLQYLKAASQILILKDGKMVQ 613
YL DDPLSAVDA V +H+FE I +L K ILVTH + YL I+++ GK+ +
Sbjct: 789 YLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISE 848
Query: 614 KGTYTEFLKSGIDFGSLLK-----KDNEESEQPPVPG-------TPTLRN---------- 651
G+Y E L F L+ + +++E+ V G + N
Sbjct: 849 MGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGK 908
Query: 652 ---RTFSESSVWSQQSSRPSLKDGALESQDT--ENVPVTLSEENRSEGKVGFQAYKNYFR 706
R S SS +S SR L+ + E + + G+V Y +Y +
Sbjct: 909 QLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMK 968
Query: 707 AGAHWIVF--IFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTE-KLDLNW 763
A +I F IFL + N V+ + ++WLS W + + VNG T+ +L +
Sbjct: 969 AIGLFISFLSIFLFMCN---HVSALASNYWLSLWTD-----DPIVNGTQEHTKVRLSVYG 1020
Query: 764 YLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILN 823
LGI G+ V FG + ++ + +L +S+ LH + SIL++P+ FF+R P G ++N
Sbjct: 1021 ALGISQGIAV----FGYSMAVSIGGIL--ASRCLHVDLLHSILRSPMSFFERTPSGNLVN 1074
Query: 824 RFSKDIGHLDDLLP 837
RFSK++ +D ++P
Sbjct: 1075 RFSKELDTVDSMIP 1088
Score = 83.2 bits (204), Expect = 1e-15
Identities = 106/489 (21%), Positives = 204/489 (41%), Gaps = 32/489 (6%)
Query: 166 LRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPL-QAIA 224
L V + H I R + +T +G +VN S +++ D + + ++ G L I
Sbjct: 1048 LHVDLLHSILRSPMSFFE----RTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIG 1103
Query: 225 VTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIR 284
++ + I+ + + +I +Q + L+ + NE + G+
Sbjct: 1104 ACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVS 1163
Query: 285 IIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSA-SKIIVFVTFTTYVLLG 343
+I+ + ++ F + ++L+ E K S + LA IV V+
Sbjct: 1164 VIRAFEEQERFIHQ-SDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISR 1222
Query: 344 SVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEA---IVSIRRIQTFLLLDEIS--QR 398
++A V ++V+ L VT + + SE IV++ R++ + ++ + Q
Sbjct: 1223 HSLSAGLVGLSVSY----SLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQI 1278
Query: 399 NRQLPSDGKKMVHVQDFTAFWDKASETP--TLQGLSFTVRPGELLAVVGPVGAGKSSLLS 456
P V +F + + E L+ ++ T+ GE + +VG GAGKSSL
Sbjct: 1279 QETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTL 1338
Query: 457 AVLGELAPSHGLVSVHG-------------RIAYVSQQPWVFSGTLRSNILFGKKYEKER 503
+ + G + + G +I + Q P +FSG+LR N+ +Y E
Sbjct: 1339 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEE 1398
Query: 504 YEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLS 563
++ LK + L D + G LS GQ+ V LARA+ + I +LD+ +
Sbjct: 1399 VWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATA 1458
Query: 564 AVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKS 623
AVD E L + I + + + H+L + +++++L G++ + G ++ L+
Sbjct: 1459 AVDLETD-DLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ 1517
Query: 624 GIDFGSLLK 632
F S+ K
Sbjct: 1518 RGLFYSMAK 1526
>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
[Homo sapiens]
Length = 1545
Score = 443 bits (1139), Expect = e-124
Identities = 295/940 (31%), Positives = 483/940 (51%), Gaps = 104/940 (11%)
Query: 7 EVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDK 66
E NP A+ S + + W + + G+KR L +D++ V E +++ L + + +
Sbjct: 189 ESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLVSKFETHMKR 248
Query: 67 EVLRA------------------------------------------------ENDAQKP 78
E+ +A + D K
Sbjct: 249 ELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKS 308
Query: 79 SLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYA 138
L +A+ K ++ L + L+ + + P L +I++ + D L Y A
Sbjct: 309 WLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTY----LWIGYLCA 364
Query: 139 TVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLL 198
+L LI + YF G+++R A+ +Y+KAL LSN+A + T G+ VNL+
Sbjct: 365 ILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLM 424
Query: 199 SNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLF 258
S D K VT F+H LW+ LQ + LW E+G S LAG+ V+++++P+ +
Sbjct: 425 SVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKS 484
Query: 259 SSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRG 318
+++ K D R++ MNE+++GI+I+K +AWE SF + + NLRKKE+ +L S L+
Sbjct: 485 KTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQC 544
Query: 319 MNLASFFSASKIIVFVTFTTYVLLGS--VITASRVFVAVTLYGAVRLTVTLFFPSAIERV 376
+ + F ++ VTF+ YVL+ S ++ A + F ++TL+ +R +++ P I +
Sbjct: 545 VVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSML-PMMISSM 603
Query: 377 SEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVR 436
+A VS R++ +L D++ + + K + + + W+ SE T++ ++ +
Sbjct: 604 LQASVSTERLEKYLGGDDLDTSAIRHDCNFDKAMQFSEASFTWEHDSEA-TVRDVNLDIM 662
Query: 437 PGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFG 496
G+L+AV+GPVG+GKSSL+SA+LGE+ HG +++ G AYV QQ W+ +GT++ NILFG
Sbjct: 663 AGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFG 722
Query: 497 KKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIY 556
++ ++RY++V++ACAL DL++L GDL IG++G LSGGQK R++LARA YQ+ DIY
Sbjct: 723 TEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIY 782
Query: 557 LLDDPLSAVDAEVSRHLFELCICQ--ILHEKITILVTHQLQYLKAASQILILKDGKMVQK 614
LLDDPLSAVDA V +H+F + +L K +LVTH + +L +I++L +G +V+K
Sbjct: 783 LLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEK 842
Query: 615 GTYTEFLKSGIDFGSLLK--------------KDNEESEQ------------PPVPGTPT 648
G+Y+ L +F LK D E E P + T
Sbjct: 843 GSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASIT 902
Query: 649 LR-----NRTFSESSVWS---QQSSRPSLKDGALES--QDTENV--PVTLSEENRSEGKV 696
+R RT S SS + +S R SLK + S +D E V + +E GKV
Sbjct: 903 MRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETGKV 962
Query: 697 GFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVT 756
F Y Y +A + +F F+IL VA++ + WLS W + + N T
Sbjct: 963 KFSIYLEYLQAIGLFSIF-FIILAFVMNSVAFIGSNLWLSAWTSDSKIFNST----DYPA 1017
Query: 757 EKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRN 816
+ D+ +G+Y L +A +F + V++S LH ++ +IL+AP+ FFD
Sbjct: 1018 SQRDMR--VGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTT 1075
Query: 817 PIGRILNRFSKDIGHLDDLLPLTFLDFIQRWDLAVLSWLV 856
P GRI+NRF+ DI +DD LP + +I + L ++S LV
Sbjct: 1076 PTGRIVNRFAGDISTVDDTLPQSLRSWITCF-LGIISTLV 1114
Score = 97.8 bits (242), Expect = 4e-20
Identities = 105/473 (22%), Positives = 205/473 (43%), Gaps = 63/473 (13%)
Query: 189 TTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILL 248
T TG+IVN + D++ D W I T ++ C+A II++
Sbjct: 1075 TPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVM------ICMATPVFTIIVI 1128
Query: 249 PLQSCFG--KLFSSLRSKTATFTDARIRT-----MNEVITGIRIIKMYAWEKSFSNLITN 301
PL + ++F S+ D+ R+ +E ++G+ +I+ + ++ F
Sbjct: 1129 PLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRF------ 1182
Query: 302 LRKKEISKILRSSCLRGM---------------NLASFFSASKIIVFVTFTTYVLLGSVI 346
L+ E+ C+ NL FFSA ++++ + +G V+
Sbjct: 1183 LKHNEVRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVL 1242
Query: 347 TASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQ--RNRQLPS 404
+ + + + TL VR+T + IV++ RI + ++ + +++ P
Sbjct: 1243 S-NALNITQTLNWLVRMT---------SEIETNIVAVERITEYTKVENEAPWVTDKRPPP 1292
Query: 405 D--GKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGEL 462
D K + ++ + + L+G++ + E + VVG GAGKSSL + + L
Sbjct: 1293 DWPSKGKIQFNNYQVRYRPELDL-VLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRIL 1351
Query: 463 APSHGLVSVHG-------------RIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIK 509
+ G + + G ++ + Q P +FSG+LR N+ Y E K ++
Sbjct: 1352 EAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKALE 1411
Query: 510 ACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEV 569
LK + L+ G + + G LS GQ+ + L RA+ + + I +LD+ +AVD E
Sbjct: 1412 LAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLET 1471
Query: 570 SRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLK 622
+L + I I + H+L + + ++++L +GK+++ G+ E L+
Sbjct: 1472 D-NLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQ 1523
>gi|89111135 ATP-binding cassette protein C12 [Homo sapiens]
Length = 1359
Score = 439 bits (1130), Expect = e-123
Identities = 289/926 (31%), Positives = 480/926 (51%), Gaps = 94/926 (10%)
Query: 1 MLPVYQ--EVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGE 58
M+PV + PNP+ DA L S F WL P+ G+++RL D + + D S +
Sbjct: 32 MIPVRPCARLAPNPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAK 91
Query: 59 ELQGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFL-GKII 117
+ WD+EV R +K SL+ + K L+ + ++ I P+ L +I+
Sbjct: 92 RFRVLWDEEVARV--GPEKASLSHVVWKFQRTRVLMDIVANILCIIMAAIGPVILIHQIL 149
Query: 118 NYFENYDPMDSVALNTAYA-YATVLT---FCTLILAILHHLYFYHVQCAGMRLRVAMCHM 173
E V + A +AT T F L AI + +RL+VA+ +
Sbjct: 150 QQTERTSGKVWVGIGLCIALFATEFTKVFFWALAWAINYR--------TAIRLKVALSTL 201
Query: 174 IYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEI 233
++ + + + G+++N+LS+D + +F P+ + A + +
Sbjct: 202 VFENLVSFKTLT--HISVGEVLNILSSDSYSLFEAALFCPLPATIPILMVFCAAYAFFIL 259
Query: 234 GISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEK 293
G + L G++V +I +P+Q KL S+ R TD R++TMNE +T IR+IKMYAWEK
Sbjct: 260 GPTALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEK 319
Query: 294 SFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFV 353
SF+N I ++R++E + ++ ++ N A S I + +T + ++LL +TA F
Sbjct: 320 SFTNTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILLRRKLTAPVAFS 379
Query: 354 AVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQ 413
+ ++ ++ ++ + P +I+ ++EA VS+RR++ +L+D+ P D ++ +
Sbjct: 380 VIAMFNVMKFSIAIL-PFSIKAMAEANVSLRRMKK-ILIDKSPPSYITQPEDPDTVLLLA 437
Query: 414 DFTAFWD-KASETPT-------------------------------------------LQ 429
+ T W+ +AS T L
Sbjct: 438 NATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYSERSPPAKGATGPEEQSDSLKSVLH 497
Query: 430 GLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTL 489
+SF VR G++L + G VG+GKSSLL+A+LG++ G+V+V+G +AYVSQQ W+F G +
Sbjct: 498 SISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGTLAYVSQQAWIFHGNV 557
Query: 490 RSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAV 549
R NILFG+KY+ +RY+ ++ C L+KDL L GDLT IG+RG LSGGQ+ R++LARAV
Sbjct: 558 RENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERGLNLSGGQRQRISLARAV 617
Query: 550 YQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDG 609
Y D +YLLDDPLSAVDA V +H+FE CI + L K +LVTHQLQ+L++ ++++L+DG
Sbjct: 618 YSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTHQLQFLESCDEVILLEDG 677
Query: 610 KMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQS----- 664
++ +KGT+ E ++ + L+ + P F ES ++
Sbjct: 678 EICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAMVEAFKESPAEREEDAGIIV 737
Query: 665 -SRPSLKDGALESQ-DTENVPVTLSE------ENRSEGKVGFQAYKNYFRAGAHWI---- 712
+ + KD ES+ +E V + E E+ EG V ++ Y Y +A ++
Sbjct: 738 LAPGNEKDEGKESETGSEFVDTKVPEHQLIQTESPQEGTVTWKTYHTYIKASGGYLLSLF 797
Query: 713 -VFIFLILLNTAAQVAYVLQDWWLSYWANKQSML------NVTVNGGGNVTEKLDLNWYL 765
VF+FL+++ +AA +WWL W +K S + N T+ G V + + Y
Sbjct: 798 TVFLFLLMIGSAA-----FSNWWLGLWLDKGSRMTCGPQGNRTMCEVGAVLADIGQHVYQ 852
Query: 766 GIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRF 825
+Y+ V ++FG+ + + + +S +LH+ +F+ ILK+P+ FFD P GR++NRF
Sbjct: 853 WVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSPMSFFDTTPTGRLMNRF 912
Query: 826 SKDIGHLDDLLPLTFLDFIQRWDLAV 851
SKD+ LD LP +F+Q++ + V
Sbjct: 913 SKDMDELDVRLPFHAENFLQQFFMVV 938
Score = 66.6 bits (161), Expect = 9e-11
Identities = 42/199 (21%), Positives = 98/199 (49%), Gaps = 14/199 (7%)
Query: 428 LQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSV-------------HGR 474
L L+ ++ G+ + +VG G+GKSSL A+ + P+ G + + +
Sbjct: 1137 LDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICILSLEDLRTK 1196
Query: 475 IAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTT 534
+ + Q P +F GT+R N+ + + E +V++ ++ + L + + + G
Sbjct: 1197 LTVIPQDPVLFVGTVRYNLDPFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGEN 1256
Query: 535 LSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQL 594
S G++ + +ARA+ +++ I LLD+ +++D++ L + I + + H+L
Sbjct: 1257 FSVGERQLLCVARALLRNSKIILLDEATASMDSKTDT-LVQNTIKDAFKGCTVLTIAHRL 1315
Query: 595 QYLKAASQILILKDGKMVQ 613
+ +L++++GK+++
Sbjct: 1316 NTVLNCDHVLVMENGKVIE 1334
>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
[Homo sapiens]
Length = 1527
Score = 438 bits (1126), Expect = e-122
Identities = 292/924 (31%), Positives = 474/924 (51%), Gaps = 93/924 (10%)
Query: 6 QEVKPNPLQD--ANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGF 63
+ V PNP + A SR+FFWW + G++ LEE D++S+ EDRSQ + ++L
Sbjct: 200 KNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEA 259
Query: 64 WDKE-----------------------VLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTL 100
W K+ +L A +KPS +A++ + S+L+ F L
Sbjct: 260 WRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKL 319
Query: 101 IEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQ 160
I++ I P L +I + N PM + A ++ C+++ +++ Y++++
Sbjct: 320 IQDLLSFINPQLLSILIRFISN--PM--APSWWGFLVAGLMFLCSMMQSLILQHYYHYIF 375
Query: 161 CAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPL 220
G++ R + +IYRKAL ++N +T G+IVNL+S D +F + FL+ LW+ PL
Sbjct: 376 VTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPL 435
Query: 221 QAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVI 280
Q I LW +G S LAG+A +++L+PL + + K D+RI+ M+E++
Sbjct: 436 QIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEIL 495
Query: 281 TGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYV 340
GI+++K+YAWE SF + +R+ E+ + ++ L ++ + ++ +T YV
Sbjct: 496 NGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYV 555
Query: 341 LL--GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQR 398
+ +V+ A + FV+V+L+ +RL + + P I +++A VS++RIQ FL +E+ +
Sbjct: 556 YVDPNNVLDAEKAFVSVSLFNILRLPLNML-PQLISNLTQASVSLKRIQQFLSQEELDPQ 614
Query: 399 N--RQLPSDGKKM-VHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLL 455
+ R+ S G + +H FT D PTL L V G L+AVVGPVG GKSSL+
Sbjct: 615 SVERKTISPGYAITIHSGTFTWAQDLP---PTLHSLDIQVPKGALVAVVGPVGCGKSSLV 671
Query: 456 SAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKK 515
SA+LGE+ G V + G +AYV QQ W+ + TL+ N+LFGK +RY++ ++ACAL
Sbjct: 672 SALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLA 731
Query: 516 DLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFE 575
DL++L GD T IG++G LSGGQ+ RV+LARAVY DADI+LLDDPLSAVD+ V++H+F+
Sbjct: 732 DLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFD 791
Query: 576 LCICQ--ILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKK 633
I +L K +LVTH + +L I++L DG++ + G Y L+ F + L
Sbjct: 792 HVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCN 851
Query: 634 DNEESEQPPVPGT----------------PTLRNR---------TFSESSVWSQQSSRPS 668
+ +Q + + TL N T+ + +Q S S
Sbjct: 852 YAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALS 911
Query: 669 LKDGALESQ--------DTENVPVT--------LSEENRSEGKVGFQAYKNYFRAGAHWI 712
DG + + +E V VT EE + G V + +Y +A
Sbjct: 912 -SDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKA-VGLC 969
Query: 713 VFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLT 772
+ + LL A + + WLS W N +M + N N + +L + LGI G
Sbjct: 970 TTLAICLLYVGQSAAAIGANVWLSAWTN-DAMADSRQN---NTSLRLGVYAALGILQGFL 1025
Query: 773 VATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHL 832
V +A + +++ LH + + +++P FFD P GRILN FSKDI +
Sbjct: 1026 VMLAAMAMAAG------GIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVV 1079
Query: 833 DDLLPLTFLDFIQRWDLAVLSWLV 856
D++L L + + A+ + +V
Sbjct: 1080 DEVLAPVILMLLNSFFNAISTLVV 1103
Score = 74.7 bits (182), Expect = 3e-13
Identities = 97/453 (21%), Positives = 193/453 (42%), Gaps = 40/453 (8%)
Query: 189 TTTGQIVNLLSNDVNKFDQVTV-FLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIIL 247
T +G+I+N S D+ D+V + L AI+ ++ + + + + ++
Sbjct: 1063 TPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLY 1122
Query: 248 LPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSF---SNLITNLRK 304
+Q + L+ + +E +TG +I+ Y + F S+ + +
Sbjct: 1123 TLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQ 1182
Query: 305 KEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLG-SVITASRVFVAVTLYGAVRL 363
+ + S+ R +++ F + +++F + ++G S + V ++V+ L
Sbjct: 1183 RSCYPYIISN--RWLSIGVEFVGNCVVLFAAL--FAVIGRSSLNPGLVGLSVSY----SL 1234
Query: 364 TVTLFFPSAIERVSEA---IVSIRRIQTFLLLD-------EISQRNRQLPSDGKKMVHVQ 413
VT I +S+ IV++ R++ + + E S+ P G+ V +
Sbjct: 1235 QVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGE--VEFR 1292
Query: 414 DFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSS-------LLSAVLGEL---- 462
+++ + + L+ LS V GE + +VG GAGKSS +L A GE+
Sbjct: 1293 NYSVRYRPGLDL-VLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDG 1351
Query: 463 --APSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLL 520
GL + ++ + Q P +FSGTLR N+ Y +E ++ L +
Sbjct: 1352 LNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQ 1411
Query: 521 EDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQ 580
G + G LS GQ+ V LARA+ + + I +LD+ +A+D E +L + I
Sbjct: 1412 PAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETD-NLIQATIRT 1470
Query: 581 ILHEKITILVTHQLQYLKAASQILILKDGKMVQ 613
+ + H+L + +++L+L G + +
Sbjct: 1471 QFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAE 1503
>gi|90421313 cystic fibrosis transmembrane conductance regulator
[Homo sapiens]
Length = 1480
Score = 414 bits (1063), Expect = e-115
Identities = 224/652 (34%), Positives = 368/652 (56%), Gaps = 42/652 (6%)
Query: 11 NPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLR 70
+PL+ A++ S++FF W P+ + G+++RLE D+Y + D + +L E+L+ WD+E+
Sbjct: 4 SPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELAS 63
Query: 71 AENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVA 130
+N P L A+ +C++ ++ GIF + E K +QP+ LG+II +YDP +
Sbjct: 64 KKN----PKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRII---ASYDPDNKEE 116
Query: 131 LNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTT 190
+ A L ++ +L H + + GM++R+AM +IY+K L+LS+ + K +
Sbjct: 117 RSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKIS 176
Query: 191 TGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPL 250
GQ+V+LLSN++NKFD+ HF+W PLQ + L+W + S G+ LI+L
Sbjct: 177 IGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALF 236
Query: 251 QSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKI 310
Q+ G++ R + A R+ +E+I I+ +K Y WE++ +I NLR+ E+
Sbjct: 237 QAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLT 296
Query: 311 LRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFP 370
+++ +R N ++FF + +VF++ Y L+ +I ++F ++ +R+ VT FP
Sbjct: 297 RKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILR-KIFTTISFCIVLRMAVTRQFP 355
Query: 371 SAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWD--------KA 422
A++ +++ +I +IQ FL E L + M +V TAFW+ KA
Sbjct: 356 WAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENV---TAFWEEGFGELFEKA 412
Query: 423 SE-----------------------TPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVL 459
+ TP L+ ++F + G+LLAV G GAGK+SLL ++
Sbjct: 413 KQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIM 472
Query: 460 GELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQL 519
GEL PS G + GRI++ SQ W+ GT++ NI+FG Y++ RY VIKAC L++D+
Sbjct: 473 GELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISK 532
Query: 520 LEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCIC 579
+ D V+G+ G TLSGGQ+AR++LARAVY+DAD+YLLD P +D + +FE C+C
Sbjct: 533 FAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVC 592
Query: 580 QILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLL 631
+++ K ILVT ++++LK A +ILIL +G GT++E DF S L
Sbjct: 593 KLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKL 644
Score = 90.1 bits (222), Expect = 8e-18
Identities = 114/497 (22%), Positives = 209/497 (42%), Gaps = 62/497 (12%)
Query: 172 HMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHF----LWAGPLQAIAVTA 227
H + L+ + G I+N S D+ D + F L + AIAV A
Sbjct: 950 HKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVA 1009
Query: 228 LLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIK 287
+L I + A + V++ + L++ F + L+ + + + G+ ++
Sbjct: 1010 VLQPYIFV---ATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLR 1066
Query: 288 MYAWEKSFSNLITN-LRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVI 346
+ + F L L + L S LR +F ++FV F V S++
Sbjct: 1067 AFGRQPYFETLFHKALNLHTANWFLYLSTLR------WFQMRIEMIFVIFFIAVTFISIL 1120
Query: 347 TAS----RVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQ----- 397
T RV + +TL + T+ S+I+ V + S+ R+ F+ + +
Sbjct: 1121 TTGEGEGRVGIILTLAMNIMSTLQWAVNSSID-VDSLMRSVSRVFKFIDMPTEGKPTKST 1179
Query: 398 ---RNRQL-----------------PSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRP 437
+N QL PS G+ + V+D TA + + L+ +SF++ P
Sbjct: 1180 KPYKNGQLSKVMIIENSHVKKDDIWPSGGQ--MTVKDLTAKYTEGGNA-ILENISFSISP 1236
Query: 438 GELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG-------------RIAYVSQQPWV 484
G+ + ++G G+GKS+LLSA L L + G + + G + Q+ ++
Sbjct: 1237 GQRVGLLGRTGSGKSTLLSAFL-RLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFI 1295
Query: 485 FSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVN 544
FSGT R N+ +++ + KV L+ ++ V+ D G LS G K +
Sbjct: 1296 FSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMC 1355
Query: 545 LARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQIL 604
LAR+V A I LLD+P + +D V+ + + Q + IL H+++ + Q L
Sbjct: 1356 LARSVLSKAKILLLDEPSAHLD-PVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFL 1414
Query: 605 ILKDGKMVQKGTYTEFL 621
++++ K+ Q + + L
Sbjct: 1415 VIEENKVRQYDSIQKLL 1431
Score = 74.7 bits (182), Expect = 3e-13
Identities = 48/135 (35%), Positives = 67/135 (49%), Gaps = 3/135 (2%)
Query: 711 WIVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSG 770
W + IFL + + V ++L + L N N N + + IY G
Sbjct: 865 WCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRN---NSYAVIITSTSSYYVFYIYVG 921
Query: 771 LTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIG 830
+ + G R L + + L+ S+ LH+KM S+L+AP+ + G ILNRFSKDI
Sbjct: 922 VADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDIA 981
Query: 831 HLDDLLPLTFLDFIQ 845
LDDLLPLT DFIQ
Sbjct: 982 ILDDLLPLTIFDFIQ 996
>gi|21729876 ATP-binding cassette, sub-family C, member 11 isoform b
[Homo sapiens]
Length = 1344
Score = 391 bits (1004), Expect = e-108
Identities = 272/888 (30%), Positives = 436/888 (49%), Gaps = 81/888 (9%)
Query: 10 PNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVL 69
P PL +A L S + WL PL + RL+E+ + + D S + L W++EV
Sbjct: 83 PQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEEVS 142
Query: 70 RAENDAQKPSLTRAIIKCYWKSYLV----LGIFTLIEESAKVIQPIFL-GKIINYFENYD 124
R +K S+ +++ + ++ L+ LGI I A V+ PI + KI+ Y E +
Sbjct: 143 R--RGIEKASVLLVMLR-FQRTRLIFDALLGICFCI---ASVLGPILIIPKILEYSE--E 194
Query: 125 PMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNM 184
+ +V +A L+ C L+ Q +R R A+ + K ++ ++
Sbjct: 195 QLGNVVHGVGLCFALFLSECVKSLSFSSSWIIN--QRTAIRFRAAVSSFAFEKLIQFKSV 252
Query: 185 AMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALL------WMEIGISCL 238
T+G+ ++ + DVN + + GPL I +L+ + IG +
Sbjct: 253 I--HITSGEAISFFTGDVNYLFEGVCY------GPLVLITCASLVICSISSYFIIGYTAF 304
Query: 239 AGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNL 298
+ +++ PL ++ + T+ +D RIR +EV+T I++IKMY WEK F+ +
Sbjct: 305 IAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKI 364
Query: 299 ITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLY 358
I +LR+KE + + ++ + + F + V + L +TAS F +
Sbjct: 365 IEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASL 424
Query: 359 GAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAF 418
+RL+V F P A++ ++ + ++ R + F L + + L K +V ++ T
Sbjct: 425 NLLRLSV-FFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVF-EEATLS 482
Query: 419 WDK-----------------ASET------------------PTLQGLSFTVRPGELLAV 443
W + ASE P L ++ V G +L V
Sbjct: 483 WQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLGV 542
Query: 444 VGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKER 503
G G+GKSSLLSA+L E+ G V V G +AYV QQ W+ SG +R NIL G Y+K R
Sbjct: 543 CGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKAR 602
Query: 504 YEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLS 563
Y +V+ C+L +DL+LL GD+T IG+RG LSGGQK R++LARAVY D IYLLDDPLS
Sbjct: 603 YLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLS 662
Query: 564 AVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKS 623
AVDA V +H+FE CI + L K +LVTHQLQYL+ QI++L++GK+ + GT++E ++
Sbjct: 663 AVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQK 722
Query: 624 GIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGAL-ESQDTENV 682
+ L++K ++E+ + T + + ES + S SL A+ E Q T+
Sbjct: 723 KGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALA-TSLEESLNGNAVPEHQLTQ-- 779
Query: 683 PVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYW---- 738
EE EG + ++ Y +Y +A ++V + + WWLSYW
Sbjct: 780 -----EEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQG 834
Query: 739 --ANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQT 796
N N T+ GN+ + L++Y +Y + + G+ S + V +S
Sbjct: 835 SGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTA 894
Query: 797 LHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFI 844
LHNK+F + + P+ FFD PIGR+LN F+ D+ LD LLP+ F+
Sbjct: 895 LHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFL 942
Score = 57.4 bits (137), Expect = 6e-08
Identities = 75/391 (19%), Positives = 150/391 (38%), Gaps = 46/391 (11%)
Query: 169 AMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVT-VFLHFLWAGPLQAIAVTA 227
A+ + ++ K R G+++N + D+ + DQ+ +F L IAV
Sbjct: 894 ALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLL 953
Query: 228 LLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIK 287
++ + L G +++I F K + + + G+ I
Sbjct: 954 IVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIH 1013
Query: 288 MYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVIT 347
+Y + F IS+ R + + L F S+++ ++ ++ V
Sbjct: 1014 VYGKTEDF-----------ISQFKRLTDAQNNYLLLFLSSTR---WMALRLEIMTNLVTL 1059
Query: 348 ASRVFVAV----TLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLP 403
A +FVA T Y + V + A + A + + F ++ I Q +
Sbjct: 1060 AVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCV 1119
Query: 404 SDGKKMVHVQDFTAFWDKASE-------------TPT-LQGLSFTVRPGELLAVVGPVGA 449
S+ + W + E TPT L G++ T+R E++ +VG G+
Sbjct: 1120 SEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGS 1179
Query: 450 GKSSLLSAVLGELAP-------------SHGLVSVHGRIAYVSQQPWVFSGTLRSNILFG 496
GKSSL A+ + P S GL + +++ + Q P + SGT+R N+
Sbjct: 1180 GKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPF 1239
Query: 497 KKYEKERYEKVIKACALKKDLQLLEDGDLTV 527
++ ++ ++ L K + L+++ ++
Sbjct: 1240 DRHTDQQIWDALERTFLTKAIILIDEATASI 1270
>gi|21729873 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 391 bits (1004), Expect = e-108
Identities = 272/888 (30%), Positives = 436/888 (49%), Gaps = 81/888 (9%)
Query: 10 PNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVL 69
P PL +A L S + WL PL + RL+E+ + + D S + L W++EV
Sbjct: 83 PQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEEVS 142
Query: 70 RAENDAQKPSLTRAIIKCYWKSYLV----LGIFTLIEESAKVIQPIFL-GKIINYFENYD 124
R +K S+ +++ + ++ L+ LGI I A V+ PI + KI+ Y E +
Sbjct: 143 R--RGIEKASVLLVMLR-FQRTRLIFDALLGICFCI---ASVLGPILIIPKILEYSE--E 194
Query: 125 PMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNM 184
+ +V +A L+ C L+ Q +R R A+ + K ++ ++
Sbjct: 195 QLGNVVHGVGLCFALFLSECVKSLSFSSSWIIN--QRTAIRFRAAVSSFAFEKLIQFKSV 252
Query: 185 AMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALL------WMEIGISCL 238
T+G+ ++ + DVN + + GPL I +L+ + IG +
Sbjct: 253 I--HITSGEAISFFTGDVNYLFEGVCY------GPLVLITCASLVICSISSYFIIGYTAF 304
Query: 239 AGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNL 298
+ +++ PL ++ + T+ +D RIR +EV+T I++IKMY WEK F+ +
Sbjct: 305 IAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKI 364
Query: 299 ITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLY 358
I +LR+KE + + ++ + + F + V + L +TAS F +
Sbjct: 365 IEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASL 424
Query: 359 GAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAF 418
+RL+V F P A++ ++ + ++ R + F L + + L K +V ++ T
Sbjct: 425 NLLRLSV-FFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVF-EEATLS 482
Query: 419 WDK-----------------ASET------------------PTLQGLSFTVRPGELLAV 443
W + ASE P L ++ V G +L V
Sbjct: 483 WQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLGV 542
Query: 444 VGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKER 503
G G+GKSSLLSA+L E+ G V V G +AYV QQ W+ SG +R NIL G Y+K R
Sbjct: 543 CGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKAR 602
Query: 504 YEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLS 563
Y +V+ C+L +DL+LL GD+T IG+RG LSGGQK R++LARAVY D IYLLDDPLS
Sbjct: 603 YLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLS 662
Query: 564 AVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKS 623
AVDA V +H+FE CI + L K +LVTHQLQYL+ QI++L++GK+ + GT++E ++
Sbjct: 663 AVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQK 722
Query: 624 GIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGAL-ESQDTENV 682
+ L++K ++E+ + T + + ES + S SL A+ E Q T+
Sbjct: 723 KGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALA-TSLEESLNGNAVPEHQLTQ-- 779
Query: 683 PVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYW---- 738
EE EG + ++ Y +Y +A ++V + + WWLSYW
Sbjct: 780 -----EEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQG 834
Query: 739 --ANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQT 796
N N T+ GN+ + L++Y +Y + + G+ S + V +S
Sbjct: 835 SGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTA 894
Query: 797 LHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFI 844
LHNK+F + + P+ FFD PIGR+LN F+ D+ LD LLP+ F+
Sbjct: 895 LHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFL 942
Score = 83.6 bits (205), Expect = 7e-16
Identities = 95/477 (19%), Positives = 192/477 (40%), Gaps = 47/477 (9%)
Query: 169 AMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVT-VFLHFLWAGPLQAIAVTA 227
A+ + ++ K R G+++N + D+ + DQ+ +F L IAV
Sbjct: 894 ALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLL 953
Query: 228 LLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIK 287
++ + L G +++I F K + + + G+ I
Sbjct: 954 IVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIH 1013
Query: 288 MYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVIT 347
+Y + F IS+ R + + L F S+++ ++ ++ V
Sbjct: 1014 VYGKTEDF-----------ISQFKRLTDAQNNYLLLFLSSTR---WMALRLEIMTNLVTL 1059
Query: 348 ASRVFVAV----TLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLP 403
A +FVA T Y + V + A + A + + F ++ I Q +
Sbjct: 1060 AVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCV 1119
Query: 404 SDGKKMVHVQDFTAFWDKASE-------------TPT-LQGLSFTVRPGELLAVVGPVGA 449
S+ + W + E TPT L G++ T+R E++ +VG G+
Sbjct: 1120 SEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGS 1179
Query: 450 GKSSLLSAVLGELAP-------------SHGLVSVHGRIAYVSQQPWVFSGTLRSNILFG 496
GKSSL A+ + P S GL + +++ + Q P + SGT+R N+
Sbjct: 1180 GKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPF 1239
Query: 497 KKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIY 556
++ ++ ++ L K + T + + G S G++ + +ARAV +++ I
Sbjct: 1240 DRHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKII 1299
Query: 557 LLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQ 613
L+D+ +++D E L + I + +++ H++ + IL++ +GK+V+
Sbjct: 1300 LIDEATASIDMETDT-LIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVE 1355
>gi|15149474 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 391 bits (1004), Expect = e-108
Identities = 272/888 (30%), Positives = 436/888 (49%), Gaps = 81/888 (9%)
Query: 10 PNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVL 69
P PL +A L S + WL PL + RL+E+ + + D S + L W++EV
Sbjct: 83 PQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEEVS 142
Query: 70 RAENDAQKPSLTRAIIKCYWKSYLV----LGIFTLIEESAKVIQPIFL-GKIINYFENYD 124
R +K S+ +++ + ++ L+ LGI I A V+ PI + KI+ Y E +
Sbjct: 143 R--RGIEKASVLLVMLR-FQRTRLIFDALLGICFCI---ASVLGPILIIPKILEYSE--E 194
Query: 125 PMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNM 184
+ +V +A L+ C L+ Q +R R A+ + K ++ ++
Sbjct: 195 QLGNVVHGVGLCFALFLSECVKSLSFSSSWIIN--QRTAIRFRAAVSSFAFEKLIQFKSV 252
Query: 185 AMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALL------WMEIGISCL 238
T+G+ ++ + DVN + + GPL I +L+ + IG +
Sbjct: 253 I--HITSGEAISFFTGDVNYLFEGVCY------GPLVLITCASLVICSISSYFIIGYTAF 304
Query: 239 AGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNL 298
+ +++ PL ++ + T+ +D RIR +EV+T I++IKMY WEK F+ +
Sbjct: 305 IAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKI 364
Query: 299 ITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLY 358
I +LR+KE + + ++ + + F + V + L +TAS F +
Sbjct: 365 IEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASL 424
Query: 359 GAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAF 418
+RL+V F P A++ ++ + ++ R + F L + + L K +V ++ T
Sbjct: 425 NLLRLSV-FFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVF-EEATLS 482
Query: 419 WDK-----------------ASET------------------PTLQGLSFTVRPGELLAV 443
W + ASE P L ++ V G +L V
Sbjct: 483 WQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLGV 542
Query: 444 VGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKER 503
G G+GKSSLLSA+L E+ G V V G +AYV QQ W+ SG +R NIL G Y+K R
Sbjct: 543 CGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKAR 602
Query: 504 YEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLS 563
Y +V+ C+L +DL+LL GD+T IG+RG LSGGQK R++LARAVY D IYLLDDPLS
Sbjct: 603 YLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLS 662
Query: 564 AVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKS 623
AVDA V +H+FE CI + L K +LVTHQLQYL+ QI++L++GK+ + GT++E ++
Sbjct: 663 AVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQK 722
Query: 624 GIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGAL-ESQDTENV 682
+ L++K ++E+ + T + + ES + S SL A+ E Q T+
Sbjct: 723 KGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALA-TSLEESLNGNAVPEHQLTQ-- 779
Query: 683 PVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYW---- 738
EE EG + ++ Y +Y +A ++V + + WWLSYW
Sbjct: 780 -----EEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQG 834
Query: 739 --ANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQT 796
N N T+ GN+ + L++Y +Y + + G+ S + V +S
Sbjct: 835 SGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTA 894
Query: 797 LHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFI 844
LHNK+F + + P+ FFD PIGR+LN F+ D+ LD LLP+ F+
Sbjct: 895 LHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFL 942
Score = 83.6 bits (205), Expect = 7e-16
Identities = 95/477 (19%), Positives = 192/477 (40%), Gaps = 47/477 (9%)
Query: 169 AMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVT-VFLHFLWAGPLQAIAVTA 227
A+ + ++ K R G+++N + D+ + DQ+ +F L IAV
Sbjct: 894 ALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLL 953
Query: 228 LLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIK 287
++ + L G +++I F K + + + G+ I
Sbjct: 954 IVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIH 1013
Query: 288 MYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVIT 347
+Y + F IS+ R + + L F S+++ ++ ++ V
Sbjct: 1014 VYGKTEDF-----------ISQFKRLTDAQNNYLLLFLSSTR---WMALRLEIMTNLVTL 1059
Query: 348 ASRVFVAV----TLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLP 403
A +FVA T Y + V + A + A + + F ++ I Q +
Sbjct: 1060 AVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCV 1119
Query: 404 SDGKKMVHVQDFTAFWDKASE-------------TPT-LQGLSFTVRPGELLAVVGPVGA 449
S+ + W + E TPT L G++ T+R E++ +VG G+
Sbjct: 1120 SEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGS 1179
Query: 450 GKSSLLSAVLGELAP-------------SHGLVSVHGRIAYVSQQPWVFSGTLRSNILFG 496
GKSSL A+ + P S GL + +++ + Q P + SGT+R N+
Sbjct: 1180 GKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPF 1239
Query: 497 KKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIY 556
++ ++ ++ L K + T + + G S G++ + +ARAV +++ I
Sbjct: 1240 DRHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKII 1299
Query: 557 LLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQ 613
L+D+ +++D E L + I + +++ H++ + IL++ +GK+V+
Sbjct: 1300 LIDEATASIDMETDT-LIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVE 1355
>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
sapiens]
Length = 1464
Score = 370 bits (949), Expect = e-102
Identities = 266/901 (29%), Positives = 425/901 (47%), Gaps = 113/901 (12%)
Query: 1 MLPVYQEVKPNPLQDA-NLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPED-RSQHLGE 58
+LP QE P +D + SR + WL PL G L + LP + +L
Sbjct: 161 LLPEDQE--PEVAEDGESWLSRFSYAWLAPLLARGACGELRQPQDICRLPHRLQPTYLAR 218
Query: 59 ELQGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIIN 118
Q W + L RA+ + + YL LG+ L+ P+ L ++
Sbjct: 219 VFQAHWQEGA----------RLWRALYGAFGRCYLALGLLKLVGTMLGFSGPLLLSLLVG 268
Query: 119 YFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKA 178
+ E L+ YA L ++ A+L + Y Y V ++ R A+ +++Y KA
Sbjct: 269 FLEE----GQEPLSHGLLYALGLAGGAVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKA 324
Query: 179 LRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCL 238
L+L + TG+ +NLL D + H W PLQ LL+ ++G++ +
Sbjct: 325 LQLGP---SRPPTGEALNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFV 381
Query: 239 AGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNL 298
G+ + ++L+P+ + + DAR++ + E+++GIR+IK WE++
Sbjct: 382 GGLILALLLVPVNKVIATRIMASNQEMLQHKDARVKLVTELLSGIRVIKFCGWEQALGAR 441
Query: 299 ITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLY 358
+ R +E+ ++ L + + + +I V F TYVL+G +TA++VF A+ L
Sbjct: 442 VEACRARELGRLRVIKYLDAACVYLWAALPVVISIVIFITYVLMGHQLTATKVFTALALV 501
Query: 359 GAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAF 418
+ L + F P I + EA VS+ RIQ FL L + + P G+ ++
Sbjct: 502 RMLILPLNNF-PWVINGLLEAKVSLDRIQLFLDLPNHNPQAYYSPDCGRLGAQIK----- 555
Query: 419 WDKASETPT-------LQGLSFT----------------VRPGELLAVVGPVGAGKSSLL 455
W S+ P L G F+ V+ G L+ +VG VG GKSSLL
Sbjct: 556 WLLCSDPPAEPSTVLELHGALFSWDPVGTSLETFISHLEVKKGMLVGIVGKVGCGKSSLL 615
Query: 456 SAVLGELAPSHGLVSVHGR---IAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACA 512
+A+ GEL G V+V G +Q+PW+ T+R NILFGK ++ + Y++V++ACA
Sbjct: 616 AAIAGELHRLRGHVAVRGLSKGFGLATQEPWIQFATIRDNILFGKTFDAQLYKEVLEACA 675
Query: 513 LKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRH 572
L DL +L GD T +G++G TLSGGQ+AR+ LARAVYQ+ ++YLLDDPL+AVDA+V+ H
Sbjct: 676 LNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDADVANH 735
Query: 573 LFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLK 632
L CI +L +L TH+ +YL+ A +L+++ G++++ G +E L
Sbjct: 736 LLHRCILGMLSYTTRLLCTHRTEYLERADAVLLMEAGRLIRAGPPSEIL----------- 784
Query: 633 KDNEESEQPPVPGTPT--LRNRTFSESSVWSQQSSRPSLKDGALESQDTENVPVTLSEEN 690
P V P N S+S+ + K+G E Q T L EE+
Sbjct: 785 --------PLVQAVPKAWAENGQESDSATAQSVQNPEKTKEGLEEEQSTSG--RLLQEES 834
Query: 691 RSEGKVGFQAYKNYFRAGAHW--IVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLN-- 746
+ EG V Y+ Y++A + +F +LL A + A DWWLS+W ++ N
Sbjct: 835 KKEGAVALHVYQAYWKAVGQGLALAILFSLLLMQATRNA---ADWWLSHWISQLKAENSS 891
Query: 747 ------------------VTVNGGGNV------------TEKLDLNWYLGIYSGLTVATV 776
+ + GN+ D+ +YL +Y+ +
Sbjct: 892 QEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIRFYLTVYATIAGVNS 951
Query: 777 LFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLL 836
L + R++L + ++ TLH ++ +L APV FF+ P GRILNRFS D+ DD L
Sbjct: 952 LCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSDVACADDSL 1011
Query: 837 P 837
P
Sbjct: 1012 P 1012
Score = 110 bits (275), Expect = 6e-24
Identities = 128/515 (24%), Positives = 231/515 (44%), Gaps = 58/515 (11%)
Query: 133 TAYA-YATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHM-IYRKALRLSNMAMGKTT 190
T YA A V + CTL+ A+L AG A H + + L T
Sbjct: 941 TVYATIAGVNSLCTLLRAVLF--------AAGTLQAAATLHRRLLHRVLMAPVTFFNATP 992
Query: 191 TGQIVNLLSNDVNKFDQVTVF-LHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLP 249
TG+I+N S+DV D F L+ L A + + A+L +G+ L++LLP
Sbjct: 993 TGRILNRFSSDVACADDSLPFILNILLANAAGLLGLLAVLG--------SGLPWLLLLLP 1044
Query: 250 --------LQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITN 301
+Q + LR + + + + G+ +++ F N
Sbjct: 1045 PLSIMYYHVQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEE--EN 1102
Query: 302 LRKKEISK---ILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLY 358
LR E+++ S+ ++ +++ + ++ + V + A+ V ++L
Sbjct: 1103 LRLLELNQRCQFATSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGL-ANPGLVGLSLS 1161
Query: 359 GAVRLTVTLF-FPSAIERVSEAIVSIRRIQTFL--LLDEISQRNRQLPSDGKKM--VHVQ 413
A+ LT L S+ + +VS+ R++ + L E + QL + V Q
Sbjct: 1162 YALSLTGLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQEPQGQPLQLGTGWLTQGGVEFQ 1221
Query: 414 DFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG 473
D + + L G++F V+PGE L +VG G+GKSSLL + L PS G V + G
Sbjct: 1222 DVVLAY-RPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDG 1280
Query: 474 -------------RIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLL 520
++A + Q+P++FSGT+R N+ ++ + +K C L + + +
Sbjct: 1281 VDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSM 1340
Query: 521 E--DGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCI 578
DG+L G+ G +LS GQ+ + LARA+ DA I +D+ ++VD + + L + I
Sbjct: 1341 GGLDGEL---GEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQ-LLQQTI 1396
Query: 579 CQILHEKITILVTHQLQYLKAASQILILKDGKMVQ 613
C+ K + + H+L + + ++L+L+ G++V+
Sbjct: 1397 CKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVE 1431
>gi|110832839 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A-delta-14 [Homo sapiens]
Length = 1513
Score = 365 bits (937), Expect = e-100
Identities = 268/907 (29%), Positives = 451/907 (49%), Gaps = 78/907 (8%)
Query: 6 QEVKP-NPLQD---------ANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQH 55
Q+VKP LQD NL S+ +WW+N L HK+ ++ + + R+
Sbjct: 200 QKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVT 259
Query: 56 LGEELQGFWDKEVLR-AENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLG 114
L+ ++++ + A++ + PS+ A+ + + + L+ F + + P+ +
Sbjct: 260 NYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCIS 319
Query: 115 KII-------NYFENYDPMDSVA-----LNTAYAYATVLTFCTLIL--AILHHLYFYHVQ 160
I+ N N + L AY A VL F LIL L Y+ ++
Sbjct: 320 GIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLA-VLLFLALILQRTFLQASYYVTIE 378
Query: 161 CAGMRLRVAMCHMIYRKALRLS--NMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAG 218
G+ LR A+ MIY K LRLS N++MG+ T GQI NL++ + N+ LWA
Sbjct: 379 -TGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAM 437
Query: 219 PLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNE 278
P+Q I LL+ +G S L G AV+++L P+Q + + T ++ R++ NE
Sbjct: 438 PVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNE 497
Query: 279 VITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTT 338
++ GI+++K+YAWE F + R KE+S + + +++ + V TF T
Sbjct: 498 ILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVT 557
Query: 339 YVLL-GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVS-EAIVSIRRIQTFLLLDEIS 396
+ G+ + + F +++L+ L LF S + R + +AI+S++++ FLL DEI
Sbjct: 558 HAYASGNNLKPAEAFASLSLFHI--LVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIG 615
Query: 397 QRN-----RQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGK 451
+ LP + K ++ S TL + + G+L +VG VG GK
Sbjct: 616 DDSWRTGESSLPFESCKKHTGVVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGK 675
Query: 452 SSLLSAVLGELAPSHGLV-------------SVHGR----IAYVSQQPWVFSGTLRSNIL 494
SSLL A+LGE+ G V + R +AY +Q+PW+ + T+ NI
Sbjct: 676 SSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENIT 735
Query: 495 FGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDAD 554
FG + K+RY+ V AC+L+ D+ LL GD T IG+RG LSGGQ+ R+ +ARA+YQ+ +
Sbjct: 736 FGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTN 795
Query: 555 IYLLDDPLSAVDAEVSRHLFELCICQILHE--KITILVTHQLQYLKAASQILILKDGKMV 612
I LDDP SA+D +S HL + I + L + + +LVTH+LQYL A I+ +KDG ++
Sbjct: 796 IVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVL 855
Query: 613 QKGTYTEFLKSGID----FGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPS 668
++GT + ++ + +L+ + ++E E+ TL +T + + ++
Sbjct: 856 REGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMY--SREAKAQ 913
Query: 669 LKDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHW--IVFIFLILLNTAAQV 726
++D E ++ E+ +S R K+ ++ Y +G + I+ IF LL + V
Sbjct: 914 MEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIV 973
Query: 727 AYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLV 786
A D+WL+ W ++ S+ N T K D +Y+ +S L A + + SL V
Sbjct: 974 AI---DYWLATWTSEYSI---------NNTGKADQTYYVAGFSILCGAGIFLCLVTSLTV 1021
Query: 787 FYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQR 846
++ + +++ LH+ + I+ P+ FFD P+G ILNRFS D +D +P T L+ + R
Sbjct: 1022 EWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPT-LESLTR 1080
Query: 847 WDLAVLS 853
L LS
Sbjct: 1081 STLLCLS 1087
Score = 87.4 bits (215), Expect = 5e-17
Identities = 103/502 (20%), Positives = 212/502 (42%), Gaps = 53/502 (10%)
Query: 159 VQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAG 218
V+ G+ + H + K + T G I+N S D N DQ H
Sbjct: 1021 VEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQ-----HI--PP 1073
Query: 219 PLQAIAVTALLWME-IGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTM- 276
L+++ + LL + IG+ A L+ LLPL F + R + + T
Sbjct: 1074 TLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQL 1133
Query: 277 ------NEVITGIRIIKMYAWEKSFSNLITNLRK-KEISKILRSSCLRGMNLASFFSASK 329
+E G+ I+ + E F + L I+ + S+ R + + + + +
Sbjct: 1134 PLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGAC 1193
Query: 330 IIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIV---SIRRI 386
I++ + + I+ S V L LT+T + + +++ V +++++
Sbjct: 1194 IVLTASIAS-------ISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKV 1246
Query: 387 QTFLLLD--------EISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPG 438
+FL ++ + SQ P +G+ +H D ++ + P L+ + ++PG
Sbjct: 1247 NSFLTMESENYEGTMDPSQVPEHWPQEGEIKIH--DLCVRYENNLK-PVLKHVKAYIKPG 1303
Query: 439 ELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG-------------RIAYVSQQPWVF 485
+ + + G G+GKSSL A + G + + G R++ + Q P +F
Sbjct: 1304 QKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILF 1363
Query: 486 SGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNL 545
SG++R N+ K +R + ++ LK ++ L G V+ + G S GQ+ L
Sbjct: 1364 SGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCL 1423
Query: 546 ARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILI 605
ARA + + I ++D+ +++D + ++ + + ++ + + H++ + A +L+
Sbjct: 1424 ARAFVRKSSILIMDEATASIDM-ATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLV 1482
Query: 606 LKDGKMVQKGTYTEFL--KSGI 625
+G +V+ T L K+G+
Sbjct: 1483 FSEGILVECDTVPNLLAHKNGL 1504
>gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1
[Homo sapiens]
Length = 1503
Score = 362 bits (928), Expect = 1e-99
Identities = 260/886 (29%), Positives = 434/886 (48%), Gaps = 77/886 (8%)
Query: 6 QEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFW- 64
Q+ P P A S+ FWW++ L G++R L D++S+ E+ S+ L L+ W
Sbjct: 198 QQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWM 257
Query: 65 -DKEVLRAENDA---------------------QKPSLTRAIIKCYWK---SYLVLGIFT 99
++ R N A Q+ S R ++K W+ S +LG +
Sbjct: 258 RNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLS 317
Query: 100 LIEESAKVIQPIF---LGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYF 156
LI I +F + K+++ F + Y A ++ + +
Sbjct: 318 LI------ISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNM 371
Query: 157 YHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLW 216
Y ++ MRLR A+ ++YRK L LS+ + + G +VNL+S DV + + ++L+ LW
Sbjct: 372 YRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLW 431
Query: 217 AGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTM 276
+ + LW +G S L +AV + LLPL K + + + D+R R
Sbjct: 432 LPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLT 491
Query: 277 NEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTF 336
+ ++ + IK + WE +F + + +R +E+ + S L ++L SF ++ ++ V F
Sbjct: 492 SSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVF 551
Query: 337 TTYVLLG-SVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEI 395
+ L+ + + A + FV +T+ + F P +I + +A VS R+ TFL L+E+
Sbjct: 552 AVHTLVAENAMNAEKAFVTLTVLNILN-KAQAFLPFSIHSLVQARVSFDRLVTFLCLEEV 610
Query: 396 S----QRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGK 451
+ + GK + + T W + S P L ++ TV G LLAVVGPVGAGK
Sbjct: 611 DPGVVDSSSSGSAAGKDCITIHSATFAWSQESP-PCLHRINLTVPQGCLLAVVGPVGAGK 669
Query: 452 SSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKAC 511
SSLLSA+LGEL+ G VS+ G +AYV Q+ WV + ++ N+ FG++ + E+V++AC
Sbjct: 670 SSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEAC 729
Query: 512 ALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSR 571
AL+ D+ +G T IG++G LSGGQK R++LARAVY+ A +YLLDDPL+A+DA V +
Sbjct: 730 ALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQ 789
Query: 572 HLFELCICQ--ILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGS 629
H+F I +L ILVTH L L A I++L +G + + G+Y E L+
Sbjct: 790 HVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVC 849
Query: 630 LL---KKDNEESEQPPVPGT-------------PTLRNRTFSESSVWSQQSSRPSLKDGA 673
LL ++ + E PGT P LR +S +++ + +
Sbjct: 850 LLDQARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVP 909
Query: 674 LESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDW 733
L+ D P +++ G+V + Y RA + ++ + L QVA + +
Sbjct: 910 LDDPDRAGWPA--GKDSIQYGRVKATVHLAYLRA-VGTPLCLYALFLFLCQQVASFCRGY 966
Query: 734 WLSYWANKQSMLNVTVNGG--GNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLV 791
WLS WA+ ++ G + L +G+++ ++A VL G AR
Sbjct: 967 WLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFA--SMAAVLLGGAR--------- 1015
Query: 792 NSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLP 837
+S+ L ++ ++++P+ FF+R PIG +LNRFSK+ +D +P
Sbjct: 1016 -ASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIP 1060
Score = 89.4 bits (220), Expect = 1e-17
Identities = 104/456 (22%), Positives = 197/456 (43%), Gaps = 28/456 (6%)
Query: 188 KTTTGQIVNLLSNDVNKFD-QVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLII 246
+T G ++N S + + D + L L + V+ ++ + ++ +A + + ++
Sbjct: 1038 RTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLL 1097
Query: 247 LLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKE 306
QS + LR + + M E G +++ + + F N R E
Sbjct: 1098 YAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQ-NNARVDE 1156
Query: 307 ISKILRSSCLRGMNLASFFSA-SKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTV 365
+I + LA+ +VF T VL + ++A V +V+ A+++T
Sbjct: 1157 SQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVS--AALQVTQ 1214
Query: 366 TL-FFPSAIERVSEAIVSIRRIQTFLLLDE-----ISQRNRQLPSDGKKMVHVQDFTAFW 419
TL + + +IVS+ R+Q + + + Q P + +DF +
Sbjct: 1215 TLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFRDFGLRY 1274
Query: 420 DKASETP-TLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVL-------------GELAPS 465
E P +QG+SF + GE + +VG GAGKSSL S +L G
Sbjct: 1275 --RPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAH 1332
Query: 466 HGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDL 525
GL ++ RI+ + Q P +F G+LR N+ +++ E ++ LK + L
Sbjct: 1333 VGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQ 1392
Query: 526 TVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEK 585
DRG LS GQK + LARA+ + I +LD+ +AVD + + + +
Sbjct: 1393 YKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQM-QAMLGSWFAQC 1451
Query: 586 ITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFL 621
+L+ H+L+ + +++L++ G++ + G+ + L
Sbjct: 1452 TVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLL 1487
>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1312
Score = 362 bits (928), Expect = 1e-99
Identities = 261/882 (29%), Positives = 432/882 (48%), Gaps = 77/882 (8%)
Query: 10 PNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFW--DKE 67
P P A S+ FWW++ L G++R L D++S+ E+ S+ L L+ W ++
Sbjct: 11 PCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRS 70
Query: 68 VLRAENDA---------------------QKPSLTRAIIKCYWK---SYLVLGIFTLIEE 103
R N A Q+ S R ++K W+ S +LG +LI
Sbjct: 71 AARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLI-- 128
Query: 104 SAKVIQPIF---LGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQ 160
I +F + K+++ F + Y A ++ + + Y ++
Sbjct: 129 ----ISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLK 184
Query: 161 CAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPL 220
MRLR A+ ++YRK L LS+ + + G +VNL+S DV + + ++L+ LW +
Sbjct: 185 VLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLV 244
Query: 221 QAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVI 280
+ LW +G S L +AV + LLPL K + + + D+R R + ++
Sbjct: 245 WIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSIL 304
Query: 281 TGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYV 340
+ IK + WE +F + + +R +E+ + S L ++L SF ++ ++ V F +
Sbjct: 305 RNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHT 364
Query: 341 LLG-SVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRN 399
L+ + + A + FV +T+ + F P +I + +A VS R+ TFL L+E+
Sbjct: 365 LVAENAMNAEKAFVTLTVLNILN-KAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPGA 423
Query: 400 RQLPSDG----KKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLL 455
S G K + +Q T W + S P L ++ TV G LLAVVGPVGAGKSSLL
Sbjct: 424 VDSSSSGSAAGKDCITIQSATFAWSQESP-PCLHRINLTVPQGCLLAVVGPVGAGKSSLL 482
Query: 456 SAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKK 515
SA+LGEL+ G VS+ G +AYV Q+ WV + ++ N+ FG++ + E+V++ACAL+
Sbjct: 483 SALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQP 542
Query: 516 DLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFE 575
D+ +G T IG++G LSGGQK R++LARAVY+ A +YLLDDPL+A+DA V +H+F
Sbjct: 543 DVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFN 602
Query: 576 LCICQ--ILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLL-- 631
I +L ILVTH L L A I++L +G + + G+Y E L+ LL
Sbjct: 603 QVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQ 662
Query: 632 -KKDNEESEQPPVPGT-------------PTLRNRTFSESSVWSQQSSRPSLKDGALESQ 677
++ + E PGT P LR +S +++ + + L+
Sbjct: 663 ARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDP 722
Query: 678 DTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSY 737
D P +++ G+V + Y RA + ++ + L QVA + +WLS
Sbjct: 723 DRAGWPA--GKDSIQYGRVKATVHLAYLRA-VGTPLCLYALFLFLCQQVASFCRGYWLSL 779
Query: 738 WANKQSMLNVTVNGG--GNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQ 795
WA+ ++ G + L +G+++ ++A VL G AR +S+
Sbjct: 780 WADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFA--SMAAVLLGGAR----------ASR 827
Query: 796 TLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLP 837
L ++ ++++P+ FF+R PIG +LNRFSK+ +D +P
Sbjct: 828 LLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIP 869
Score = 90.9 bits (224), Expect = 5e-18
Identities = 105/456 (23%), Positives = 197/456 (43%), Gaps = 28/456 (6%)
Query: 188 KTTTGQIVNLLSNDVNKFD-QVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLII 246
+T G ++N S + + D + L L + V+ ++ + ++ +A + + ++
Sbjct: 847 RTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLL 906
Query: 247 LLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKE 306
QS + LR + + M E G +++ + + F N R E
Sbjct: 907 YAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQ-NNARVDE 965
Query: 307 ISKILRSSCLRGMNLASFFSA-SKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTV 365
+I + LA+ +VF T VL + ++A V +V+ A+++T
Sbjct: 966 SQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVS--AALQVTQ 1023
Query: 366 TL-FFPSAIERVSEAIVSIRRIQTFLLLDE-----ISQRNRQLPSDGKKMVHVQDFTAFW 419
TL + + +IVS+ R+Q + + + Q P + QDF +
Sbjct: 1024 TLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFQDFGLRY 1083
Query: 420 DKASETP-TLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVL-------------GELAPS 465
E P +QG+SF + GE + +VG GAGKSSL S +L G
Sbjct: 1084 --RPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAH 1141
Query: 466 HGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDL 525
GL ++ RI+ + Q P +F G+LR N+ +++ E ++ LK + L
Sbjct: 1142 VGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQ 1201
Query: 526 TVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEK 585
DRG LS GQK + LARA+ + I +LD+ +AVD + + + +
Sbjct: 1202 YKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQM-QAMLGSWFAQC 1260
Query: 586 ITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFL 621
+L+ H+L+ + +++L++ G++ + G+ + L
Sbjct: 1261 TVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLL 1296
>gi|110832835 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A [Homo sapiens]
Length = 1549
Score = 355 bits (910), Expect = 1e-97
Identities = 268/943 (28%), Positives = 454/943 (48%), Gaps = 114/943 (12%)
Query: 6 QEVKP-NPLQD---------ANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQH 55
Q+VKP LQD NL S+ +WW+N L HK+ ++ + + R+
Sbjct: 200 QKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVT 259
Query: 56 LGEELQGFWDKEVLR-AENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLG 114
L+ ++++ + A++ + PS+ A+ + + + L+ F + + P+ +
Sbjct: 260 NYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCIS 319
Query: 115 KII-------NYFENYDPMDSVA-----LNTAYAYATVLTFCTLIL--AILHHLYFYHVQ 160
I+ N N + L AY A VL F LIL L Y+ ++
Sbjct: 320 GIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLA-VLLFLALILQRTFLQASYYVTIE 378
Query: 161 CAGMRLRVAMCHMIYRKALRLS--NMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAG 218
G+ LR A+ MIY K LRLS N++MG+ T GQI NL++ + N+ LWA
Sbjct: 379 -TGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAM 437
Query: 219 PLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNE 278
P+Q I LL+ +G S L G AV+++L P+Q + + T ++ R++ NE
Sbjct: 438 PVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNE 497
Query: 279 VITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTT 338
++ GI+++K+YAWE F + R KE+S + + +++ + V TF T
Sbjct: 498 ILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVT 557
Query: 339 YVLL-GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVS-EAIVSIRRIQTFLLLDEIS 396
+ G+ + + F +++L+ L LF S + R + +AI+S++++ FLL DEI
Sbjct: 558 HAYASGNNLKPAEAFASLSLFHI--LVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIG 615
Query: 397 -----------------------------------------QRNRQLPSDGKKMVHVQDF 415
Q R+L + + ++
Sbjct: 616 DDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRPAETEDIAIKVT 675
Query: 416 TAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLV------ 469
++ S TL + + G+L +VG VG GKSSLL A+LGE+ G V
Sbjct: 676 NGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVN 735
Query: 470 -------SVHGR----IAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQ 518
+ R +AY +Q+PW+ + T+ NI FG + K+RY+ V AC+L+ D+
Sbjct: 736 ESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDID 795
Query: 519 LLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCI 578
LL GD T IG+RG LSGGQ+ R+ +ARA+YQ+ +I LDDP SA+D +S HL + I
Sbjct: 796 LLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGI 855
Query: 579 CQILHE--KITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGID----FGSLLK 632
+ L + + +LVTH+LQYL A I+ +KDG ++++GT + ++ + +L+
Sbjct: 856 LKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMN 915
Query: 633 KDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDTENVPVTLSEENRS 692
+ ++E E+ TL +T + + ++ ++D E ++ E+ +S R
Sbjct: 916 RQDQELEKDMEADQTTLERKTLRRAMY--SREAKAQMEDEDEEEEEEEDEDDNMSTVMRL 973
Query: 693 EGKVGFQAYKNYFRAGAHW--IVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVN 750
K+ ++ Y +G + I+ IF LL + VA D+WL+ W ++ S+
Sbjct: 974 RTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAI---DYWLATWTSEYSI------ 1024
Query: 751 GGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPV 810
N T K D +Y+ +S L A + + SL V ++ + +++ LH+ + I+ P+
Sbjct: 1025 ---NNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPI 1081
Query: 811 LFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQRWDLAVLS 853
FFD P+G ILNRFS D +D +P T L+ + R L LS
Sbjct: 1082 RFFDTTPLGLILNRFSADTNIIDQHIPPT-LESLTRSTLLCLS 1123
Score = 87.4 bits (215), Expect = 5e-17
Identities = 103/502 (20%), Positives = 212/502 (42%), Gaps = 53/502 (10%)
Query: 159 VQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAG 218
V+ G+ + H + K + T G I+N S D N DQ H
Sbjct: 1057 VEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQ-----HI--PP 1109
Query: 219 PLQAIAVTALLWME-IGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTM- 276
L+++ + LL + IG+ A L+ LLPL F + R + + T
Sbjct: 1110 TLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQL 1169
Query: 277 ------NEVITGIRIIKMYAWEKSFSNLITNLRK-KEISKILRSSCLRGMNLASFFSASK 329
+E G+ I+ + E F + L I+ + S+ R + + + + +
Sbjct: 1170 PLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGAC 1229
Query: 330 IIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIV---SIRRI 386
I++ + + I+ S V L LT+T + + +++ V +++++
Sbjct: 1230 IVLTASIAS-------ISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKV 1282
Query: 387 QTFLLLD--------EISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPG 438
+FL ++ + SQ P +G+ +H D ++ + P L+ + ++PG
Sbjct: 1283 NSFLTMESENYEGTMDPSQVPEHWPQEGEIKIH--DLCVRYENNLK-PVLKHVKAYIKPG 1339
Query: 439 ELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG-------------RIAYVSQQPWVF 485
+ + + G G+GKSSL A + G + + G R++ + Q P +F
Sbjct: 1340 QKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILF 1399
Query: 486 SGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNL 545
SG++R N+ K +R + ++ LK ++ L G V+ + G S GQ+ L
Sbjct: 1400 SGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCL 1459
Query: 546 ARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILI 605
ARA + + I ++D+ +++D + ++ + + ++ + + H++ + A +L+
Sbjct: 1460 ARAFVRKSSILIMDEATASIDM-ATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLV 1518
Query: 606 LKDGKMVQKGTYTEFL--KSGI 625
+G +V+ T L K+G+
Sbjct: 1519 FSEGILVECDTVPNLLAHKNGL 1540
>gi|110832837 ATP-binding cassette, sub-family C, member 9 isoform
SUR2B [Homo sapiens]
Length = 1549
Score = 355 bits (910), Expect = 1e-97
Identities = 268/943 (28%), Positives = 454/943 (48%), Gaps = 114/943 (12%)
Query: 6 QEVKP-NPLQD---------ANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQH 55
Q+VKP LQD NL S+ +WW+N L HK+ ++ + + R+
Sbjct: 200 QKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVT 259
Query: 56 LGEELQGFWDKEVLR-AENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLG 114
L+ ++++ + A++ + PS+ A+ + + + L+ F + + P+ +
Sbjct: 260 NYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCIS 319
Query: 115 KII-------NYFENYDPMDSVA-----LNTAYAYATVLTFCTLIL--AILHHLYFYHVQ 160
I+ N N + L AY A VL F LIL L Y+ ++
Sbjct: 320 GIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLA-VLLFLALILQRTFLQASYYVTIE 378
Query: 161 CAGMRLRVAMCHMIYRKALRLS--NMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAG 218
G+ LR A+ MIY K LRLS N++MG+ T GQI NL++ + N+ LWA
Sbjct: 379 -TGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAM 437
Query: 219 PLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNE 278
P+Q I LL+ +G S L G AV+++L P+Q + + T ++ R++ NE
Sbjct: 438 PVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNE 497
Query: 279 VITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTT 338
++ GI+++K+YAWE F + R KE+S + + +++ + V TF T
Sbjct: 498 ILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVT 557
Query: 339 YVLL-GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVS-EAIVSIRRIQTFLLLDEIS 396
+ G+ + + F +++L+ L LF S + R + +AI+S++++ FLL DEI
Sbjct: 558 HAYASGNNLKPAEAFASLSLFHI--LVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIG 615
Query: 397 -----------------------------------------QRNRQLPSDGKKMVHVQDF 415
Q R+L + + ++
Sbjct: 616 DDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRPAETEDIAIKVT 675
Query: 416 TAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLV------ 469
++ S TL + + G+L +VG VG GKSSLL A+LGE+ G V
Sbjct: 676 NGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVN 735
Query: 470 -------SVHGR----IAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQ 518
+ R +AY +Q+PW+ + T+ NI FG + K+RY+ V AC+L+ D+
Sbjct: 736 ESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDID 795
Query: 519 LLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCI 578
LL GD T IG+RG LSGGQ+ R+ +ARA+YQ+ +I LDDP SA+D +S HL + I
Sbjct: 796 LLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGI 855
Query: 579 CQILHE--KITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGID----FGSLLK 632
+ L + + +LVTH+LQYL A I+ +KDG ++++GT + ++ + +L+
Sbjct: 856 LKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMN 915
Query: 633 KDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDTENVPVTLSEENRS 692
+ ++E E+ TL +T + + ++ ++D E ++ E+ +S R
Sbjct: 916 RQDQELEKDMEADQTTLERKTLRRAMY--SREAKAQMEDEDEEEEEEEDEDDNMSTVMRL 973
Query: 693 EGKVGFQAYKNYFRAGAHW--IVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVN 750
K+ ++ Y +G + I+ IF LL + VA D+WL+ W ++ S+
Sbjct: 974 RTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAI---DYWLATWTSEYSI------ 1024
Query: 751 GGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPV 810
N T K D +Y+ +S L A + + SL V ++ + +++ LH+ + I+ P+
Sbjct: 1025 ---NNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPI 1081
Query: 811 LFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQRWDLAVLS 853
FFD P+G ILNRFS D +D +P T L+ + R L LS
Sbjct: 1082 RFFDTTPLGLILNRFSADTNIIDQHIPPT-LESLTRSTLLCLS 1123
Score = 88.6 bits (218), Expect = 2e-17
Identities = 104/511 (20%), Positives = 218/511 (42%), Gaps = 54/511 (10%)
Query: 159 VQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAG 218
V+ G+ + H + K + T G I+N S D N DQ H
Sbjct: 1057 VEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQ-----HI--PP 1109
Query: 219 PLQAIAVTALLWME-IGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTM- 276
L+++ + LL + IG+ A L+ LLPL F + R + + T
Sbjct: 1110 TLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQL 1169
Query: 277 ------NEVITGIRIIKMYAWEKSFSNLITNLRK-KEISKILRSSCLRGMNLASFFSASK 329
+E G+ I+ + E F + L I+ + S+ R + + + + +
Sbjct: 1170 PLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGAC 1229
Query: 330 IIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIV---SIRRI 386
I++ + + I+ S V L LT+T + + +++ V +++++
Sbjct: 1230 IVLTASIAS-------ISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKV 1282
Query: 387 QTFLLLD--------EISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPG 438
+FL ++ + SQ P +G+ +H D ++ + P L+ + ++PG
Sbjct: 1283 NSFLTMESENYEGTMDPSQVPEHWPQEGEIKIH--DLCVRYENNLK-PVLKHVKAYIKPG 1339
Query: 439 ELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG-------------RIAYVSQQPWVF 485
+ + + G G+GKSSL A + G + + G R++ + Q P +F
Sbjct: 1340 QKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILF 1399
Query: 486 SGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNL 545
SG++R N+ K +R + ++ LK ++ L G V+ + G S GQ+ L
Sbjct: 1400 SGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCL 1459
Query: 546 ARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILI 605
ARA + + I ++D+ +++D + ++ + + ++ + + H++ + A +++
Sbjct: 1460 ARAFVRKSSILIMDEATASIDM-ATENILQKVVMTAFADRTVVTIAHRVHTILTADLVIV 1518
Query: 606 LKDGKMVQKGTYTEFL--KSGIDFGSLLKKD 634
+K G +++ T L ++G+ F S ++ D
Sbjct: 1519 MKRGNILEYDTPESLLAQENGV-FASFVRAD 1548
>gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3
[Homo sapiens]
Length = 1475
Score = 340 bits (872), Expect = 3e-93
Identities = 251/904 (27%), Positives = 432/904 (47%), Gaps = 136/904 (15%)
Query: 3 PVYQEV----KPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGE 58
P++ E P P A+ SR+ FWW+ L G+++ LE D++S+ ED S+ +
Sbjct: 196 PLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVP 255
Query: 59 ELQGFWDKEVLRAENDAQK------------------------------------PSLTR 82
L W KE + K PSL +
Sbjct: 256 VLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFK 315
Query: 83 AIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLT 142
+ K + +L+ F I + P L +I + D+ A + + TVL
Sbjct: 316 VLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVN-----DTKAPDWQGYFYTVLL 370
Query: 143 FCTLIL-AILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSND 201
F T L ++ H YF+ +GMR++ A+ +YRKAL ++N A +T G+IVNL+S D
Sbjct: 371 FVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVD 430
Query: 202 VNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSL 261
+F + +++ +W+ PLQ I LLW+ +G S LAG+AV+++++P+ + +
Sbjct: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTY 490
Query: 262 RSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNL 321
+ D RI+ MNE++ GI+++K+YAWE +F + + +R++E+ + +S+ L +
Sbjct: 491 QVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGT 550
Query: 322 ASFFSASKIIVFVTFTTYVLL--GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEA 379
++ ++ TF YV + +++ A FV++ L+ +R + + P I + +A
Sbjct: 551 FTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNI-LPMVISSIVQA 609
Query: 380 IVSIRRIQTFLLLDEIS----QRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTV 435
VS++R++ FL +E+ +R G + V++ T W + S+ PTL G++F++
Sbjct: 610 SVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWAR-SDPPTLNGITFSI 668
Query: 436 RPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILF 495
G L+AVVG VG GKSSLLSA+L E+ G V++ G +AYV QQ W+ + +LR NILF
Sbjct: 669 PEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILF 728
Query: 496 GKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADI 555
G + E+ Y VI+ACAL DL++L GD T I G+K R+ + ++
Sbjct: 729 GCQLEEPYYRSVIQACALLPDLEILPSGDRTEI---------GEKTRILVTHSM------ 773
Query: 556 YLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKG 615
L VD I ++ ++ + + ++L + G
Sbjct: 774 ----SYLPQVDV------------------IIVMSGGKISEMGSYQELL-------ARDG 804
Query: 616 TYTEFLKSGIDFGSLLKKDNEESEQPPVPG----TPTLRNRTFSESSVWSQ---QSSRPS 668
+ EFL++ + ++D EE+ V G + N S Q Q S S
Sbjct: 805 AFAEFLRTYA--STEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSS 862
Query: 669 LKDGALESQDTENVPVTLSEENRSE------------GKVGFQAYKNYFRAGAHWIVF-- 714
G + + +E + E G+V Y +Y +A +I F
Sbjct: 863 SYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLS 922
Query: 715 IFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTE-KLDLNWYLGIYSGLTV 773
IFL + N V+ + ++WLS W + + VNG T+ +L + LGI G+ V
Sbjct: 923 IFLFMCN---HVSALASNYWLSLWTD-----DPIVNGTQEHTKVRLSVYGALGISQGIAV 974
Query: 774 ATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLD 833
FG + ++ + +L +S+ LH + SIL++P+ FF+R P G ++NRFSK++ +D
Sbjct: 975 ----FGYSMAVSIGGIL--ASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVD 1028
Query: 834 DLLP 837
++P
Sbjct: 1029 SMIP 1032
Score = 83.2 bits (204), Expect = 1e-15
Identities = 106/489 (21%), Positives = 204/489 (41%), Gaps = 32/489 (6%)
Query: 166 LRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPL-QAIA 224
L V + H I R + +T +G +VN S +++ D + + ++ G L I
Sbjct: 992 LHVDLLHSILRSPMSFFE----RTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIG 1047
Query: 225 VTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIR 284
++ + I+ + + +I +Q + L+ + NE + G+
Sbjct: 1048 ACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVS 1107
Query: 285 IIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSA-SKIIVFVTFTTYVLLG 343
+I+ + ++ F + ++L+ E K S + LA IV V+
Sbjct: 1108 VIRAFEEQERFIHQ-SDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISR 1166
Query: 344 SVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEA---IVSIRRIQTFLLLDEIS--QR 398
++A V ++V+ L VT + + SE IV++ R++ + ++ + Q
Sbjct: 1167 HSLSAGLVGLSVSY----SLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQI 1222
Query: 399 NRQLPSDGKKMVHVQDFTAFWDKASETP--TLQGLSFTVRPGELLAVVGPVGAGKSSLLS 456
P V +F + + E L+ ++ T+ GE + +VG GAGKSSL
Sbjct: 1223 QETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTL 1282
Query: 457 AVLGELAPSHGLVSVHG-------------RIAYVSQQPWVFSGTLRSNILFGKKYEKER 503
+ + G + + G +I + Q P +FSG+LR N+ +Y E
Sbjct: 1283 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEE 1342
Query: 504 YEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLS 563
++ LK + L D + G LS GQ+ V LARA+ + I +LD+ +
Sbjct: 1343 VWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATA 1402
Query: 564 AVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKS 623
AVD E L + I + + + H+L + +++++L G++ + G ++ L+
Sbjct: 1403 AVDLETD-DLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ 1461
Query: 624 GIDFGSLLK 632
F S+ K
Sbjct: 1462 RGLFYSMAK 1470
>gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo
sapiens]
Length = 1581
Score = 332 bits (852), Expect = 7e-91
Identities = 262/962 (27%), Positives = 445/962 (46%), Gaps = 122/962 (12%)
Query: 6 QEVKP-NPLQD---------ANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQH 55
+EVKP LQD NL S+ +WW+N K HK+ ++ + + R+
Sbjct: 202 REVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALT 261
Query: 56 LGEELQGFWDKEVLRAENDAQKP-SLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLG 114
+ L +D +V + Q ++ +A+ + + ++ F ++ + P+ +
Sbjct: 262 NYQRLCEAFDAQVRKDIQGTQGARAIWQALSHAFGRRLVLSSTFRILADLLGFAGPLCIF 321
Query: 115 KIINYF--EN------------YDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQ 160
I+++ EN Y L AY A +L L+ +Y
Sbjct: 322 GIVDHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAVLLFLALLLQRTFLQASYYVAI 381
Query: 161 CAGMRLRVAMCHMIYRKALRLS--NMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAG 218
G+ LR A+ IY K + LS N++MG+ T GQI NL++ D N+ LWA
Sbjct: 382 ETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAM 441
Query: 219 PLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNE 278
P+Q I LL+ +G+S L G AV+I+L P+Q S + T +++ R++ NE
Sbjct: 442 PVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNE 501
Query: 279 VITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTT 338
++ GI+++K+YAWE F + R+KE++ + + +++ + V +TF
Sbjct: 502 MLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISIFMNTAIPIAAVLITFVG 561
Query: 339 YVLL--GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEIS 396
+V + + S F +++L+ + +T S + +A+VS++++ FL EI
Sbjct: 562 HVSFFKEADFSPSVAFASLSLFH-ILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIR 620
Query: 397 QR------------------------NRQLPSDG---------KKMVHVQDFTA------ 417
+ NR+ P+ + +V D A
Sbjct: 621 EEQCAPHEPTPQGPASKYQAVPLRVVNRKRPAREDCRGLTGPLQSLVPSADGDADNCCVQ 680
Query: 418 -----FWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLV--- 469
F PTL ++ + G+L +VG VG GKSSLL A LGE+ G V
Sbjct: 681 IMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWS 740
Query: 470 -----------------------SVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEK 506
G +AY SQ+PW+ + T+ NI+F + K+RY+
Sbjct: 741 SLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNKQRYKM 800
Query: 507 VIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVD 566
VI+AC+L+ D+ +L GD T IG+RG LSGGQ+ R+++ARA+YQ A++ LDDP SA+D
Sbjct: 801 VIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALD 860
Query: 567 AEVSRHLFELCICQILHE--KITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSG 624
+S HL + I ++L + + +LVTH+LQYL A I+ +KDG + ++GT +F +S
Sbjct: 861 IHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSE 920
Query: 625 ID----FGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDTE 680
+ +L+ + ++E E+ T T R T + SSR DG L+ ++ E
Sbjct: 921 CQLFEHWKTLMNRQDQELEKE----TVTERKATEPPQGLSRAMSSR----DGLLQDEEEE 972
Query: 681 NVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAA------QVAYVLQDWW 734
SEE+ + + Q + +RA A ++ ++LL+ + V D+W
Sbjct: 973 EEEAAESEEDDNLSSMLHQRAEIPWRACAKYLSSAGILLLSLLVFSQLLKHMVLVAIDYW 1032
Query: 735 LSYWANKQSMLNVTVNGGGNVTE-KLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNS 793
L+ W + L E LD Y +++ L ++ + S+ V + +
Sbjct: 1033 LAKWTDSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCLVTSVTVEWTGLKV 1092
Query: 794 SQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQRWDLAVLS 853
++ LH + I+ AP+ FF+ P+G ILNRFS D +D +P T L+ + R L +S
Sbjct: 1093 AKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPST-LECLSRSTLLCVS 1151
Query: 854 WL 855
L
Sbjct: 1152 AL 1153
Score = 93.2 bits (230), Expect = 9e-19
Identities = 95/504 (18%), Positives = 214/504 (42%), Gaps = 35/504 (6%)
Query: 137 YATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVN 196
YA V T + +L + V+ G+++ + + + + T G I+N
Sbjct: 1063 YAMVFTVLCSLGIVLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILN 1122
Query: 197 LLSNDVNKFDQ-VTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFG 255
S+D N DQ + L L L ++ A++ + +A + + I+ +Q F
Sbjct: 1123 RFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFR 1182
Query: 256 KLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSN-LITNLRKKEISKILRSS 314
L+ T + E + G+ I+ + +E F L+ I+ + ++
Sbjct: 1183 VASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTA 1242
Query: 315 CLRGMNLASFFSASKIIVFVTFTTYV-LLGSVITASRVFVAVTLYGAVRLTVTLFFPSAI 373
R + + + + +++ T+ L ++A V + +T L V+ + +
Sbjct: 1243 ANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTY----ALMVSNYLNWMV 1298
Query: 374 ERVSEA---IVSIRRIQTFLLLDEISQRN--------RQLPSDGKKMVHVQDFTAFWDKA 422
+++ + +++RI L + S + P GK + +Q+ + +D +
Sbjct: 1299 RNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGK--IQIQNLSVRYD-S 1355
Query: 423 SETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG--------- 473
S P L+ ++ + PG+ + + G G+GKSS A + G + + G
Sbjct: 1356 SLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLH 1415
Query: 474 ----RIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIG 529
R++ + Q P +FSGT+R N+ +K + ++ LK ++ L G +I
Sbjct: 1416 TLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIIT 1475
Query: 530 DRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITIL 589
+ G S GQ+ LARA + I+++D+ +++D + ++ + + ++ +
Sbjct: 1476 EGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDM-ATENILQKVVMTAFADRTVVT 1534
Query: 590 VTHQLQYLKAASQILILKDGKMVQ 613
+ H++ + +A +++LK G +++
Sbjct: 1535 IAHRVHTILSADLVIVLKRGAILE 1558
>gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2
[Homo sapiens]
Length = 1472
Score = 322 bits (825), Expect = 9e-88
Identities = 247/914 (27%), Positives = 422/914 (46%), Gaps = 159/914 (17%)
Query: 3 PVYQEV----KPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGE 58
P++ E P P A+ SR+ FWW+ L G+++ LE D++S+ ED S+ +
Sbjct: 196 PLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVP 255
Query: 59 ELQGFWDKEVLRAENDAQK------------------------------------PSLTR 82
L W KE + K PSL +
Sbjct: 256 VLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFK 315
Query: 83 AIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLT 142
+ K + +L+ F I + P L +I + D+ A + + TVL
Sbjct: 316 VLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVN-----DTKAPDWQGYFYTVLL 370
Query: 143 FCTLIL-AILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSND 201
F T L ++ H YF+ +GMR++ A+ +YRKAL ++N A +T G+IVNL+S D
Sbjct: 371 FVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVD 430
Query: 202 VNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSL 261
+F + +++ +W+ PLQ I LLW+ +G S LAG+AV+++++P+ + +
Sbjct: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTY 490
Query: 262 RSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNL 321
+ D RI+ MNE++ GI+++K+YAWE +F + + +R++E+ + +S+ L +
Sbjct: 491 QVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGT 550
Query: 322 ASFFSASKIIVFVTFTTYVLL--GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEA 379
++ ++ TF YV + +++ A FV++ L+ +R + + P I + +A
Sbjct: 551 FTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNI-LPMVISSIVQA 609
Query: 380 IVSIRRIQTFLLLDEIS----QRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTV 435
VS++R++ FL +E+ +R G + V++ T W + S+ PTL G++F++
Sbjct: 610 SVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWAR-SDPPTLNGITFSI 668
Query: 436 RPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILF 495
G L+AVVG VG GKSSLLSA+L E+ G V++ G N+
Sbjct: 669 PEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG-----------------VNLSG 711
Query: 496 GKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADI 555
G+K + + +A D+ L +D
Sbjct: 712 GQK----QRVSLARAVYSNADIYLFDD--------------------------------- 734
Query: 556 YLLDDPLSAVDAEVSRHLFELCICQ--ILHEKITILVTHQLQYLKAASQILILKDGKMVQ 613
PLSAVDA V +H+FE I +L K ILVTH + YL I+++ GK+ +
Sbjct: 735 -----PLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISE 789
Query: 614 KGTYTEFLKSGIDFGSLLK-----KDNEESEQPPVPG-------TPTLRN---------- 651
G+Y E L F L+ + +++E+ V G + N
Sbjct: 790 MGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGK 849
Query: 652 ---RTFSESSVWSQQSSRPSLKDGALESQDT--ENVPVTLSEENRSEGKVGFQAYKNYFR 706
R S SS +S SR L+ + E + + G+V Y +Y +
Sbjct: 850 QLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMK 909
Query: 707 AGAHWIVF--IFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTE-KLDLNW 763
A +I F IFL + N V+ + ++WLS W + + VNG T+ +L +
Sbjct: 910 AIGLFISFLSIFLFMCN---HVSALASNYWLSLWTD-----DPIVNGTQEHTKVRLSVYG 961
Query: 764 YLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILN 823
LGI G+ V FG + ++ + +L +S+ LH + SIL++P+ FF+R P G ++N
Sbjct: 962 ALGISQGIAV----FGYSMAVSIGGIL--ASRCLHVDLLHSILRSPMSFFERTPSGNLVN 1015
Query: 824 RFSKDIGHLDDLLP 837
RFSK++ +D ++P
Sbjct: 1016 RFSKELDTVDSMIP 1029
Score = 83.2 bits (204), Expect = 1e-15
Identities = 106/489 (21%), Positives = 204/489 (41%), Gaps = 32/489 (6%)
Query: 166 LRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPL-QAIA 224
L V + H I R + +T +G +VN S +++ D + + ++ G L I
Sbjct: 989 LHVDLLHSILRSPMSFFE----RTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIG 1044
Query: 225 VTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIR 284
++ + I+ + + +I +Q + L+ + NE + G+
Sbjct: 1045 ACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVS 1104
Query: 285 IIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSA-SKIIVFVTFTTYVLLG 343
+I+ + ++ F + ++L+ E K S + LA IV V+
Sbjct: 1105 VIRAFEEQERFIHQ-SDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISR 1163
Query: 344 SVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEA---IVSIRRIQTFLLLDEIS--QR 398
++A V ++V+ L VT + + SE IV++ R++ + ++ + Q
Sbjct: 1164 HSLSAGLVGLSVSY----SLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQI 1219
Query: 399 NRQLPSDGKKMVHVQDFTAFWDKASETP--TLQGLSFTVRPGELLAVVGPVGAGKSSLLS 456
P V +F + + E L+ ++ T+ GE + +VG GAGKSSL
Sbjct: 1220 QETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTL 1279
Query: 457 AVLGELAPSHGLVSVHG-------------RIAYVSQQPWVFSGTLRSNILFGKKYEKER 503
+ + G + + G +I + Q P +FSG+LR N+ +Y E
Sbjct: 1280 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEE 1339
Query: 504 YEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLS 563
++ LK + L D + G LS GQ+ V LARA+ + I +LD+ +
Sbjct: 1340 VWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATA 1399
Query: 564 AVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKS 623
AVD E L + I + + + H+L + +++++L G++ + G ++ L+
Sbjct: 1400 AVDLETD-DLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ 1458
Query: 624 GIDFGSLLK 632
F S+ K
Sbjct: 1459 RGLFYSMAK 1467
>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
[Homo sapiens]
Length = 1437
Score = 281 bits (718), Expect = 2e-75
Identities = 153/429 (35%), Positives = 242/429 (56%), Gaps = 20/429 (4%)
Query: 427 TLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFS 486
TL + ++ G+L+ + G VG+GK+SL+SA+LG++ G +++ G AYV+QQ W+ +
Sbjct: 577 TLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILN 636
Query: 487 GTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLA 546
TLR NILFGK+Y++ERY V+ +C L+ DL +L DLT IG+RG LSGGQ+ R++LA
Sbjct: 637 ATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLA 696
Query: 547 RAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILIL 606
RA+Y D IY+LDDPLSA+DA V H+F I + L K + VTHQLQYL +++ +
Sbjct: 697 RALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFM 756
Query: 607 KDGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSR 666
K+G + ++GT+ E + D+ ++ + E PPV + ++ + S Q
Sbjct: 757 KEGCITERGTHEELMNLNGDYATIF-NNLLLGETPPV----EINSKKETSGSQKKSQDKG 811
Query: 667 PSL----KDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNT 722
P K+ A++ ++ + V + E + +G V + Y Y +A + F+ ++ L
Sbjct: 812 PKTGSVKKEKAVKPEEGQLVQL----EEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFM 867
Query: 723 AAQVAYVLQDWWLSYWANKQSMLNVTVNGGG------NVTEKLDLNWYLGIYSGLTVATV 776
+ WWLSYW KQ N TV G ++ + + +Y IY+ +
Sbjct: 868 LNVGSTAFSTWWLSYWI-KQGSGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVML 926
Query: 777 LFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLL 836
+ R ++ + +S LH+++F IL++P+ FFD P GRILNRFSKD+ +D L
Sbjct: 927 ILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRL 986
Query: 837 PLTFLDFIQ 845
P FIQ
Sbjct: 987 PFQAEMFIQ 995
Score = 144 bits (362), Expect = 5e-34
Identities = 108/419 (25%), Positives = 207/419 (49%), Gaps = 22/419 (5%)
Query: 11 NPLQDANLCSRVFFWWLNPLFKIGHKR-RLEEDDMYSVLPEDRSQHLGEELQGFWDKEVL 69
+P+ +A L S + F WL+ L ++ HK+ L +D++S+ + S L+ W +E+
Sbjct: 99 HPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELN 158
Query: 70 RAENDAQKPSLTRAIIKCYWKSYLVLGIFTL-IEESAKVIQPIFLGK-IINYFENYDPMD 127
DA R ++ + ++ L+L I L I + A P F+ K ++ Y +
Sbjct: 159 EVGPDAAS---LRRVVWIFCRTRLILSIVCLMITQLAGFSGPAFMVKHLLEYTQ------ 209
Query: 128 SVALNTAYAYATVLTFCTLILAILHH----LYFYHVQCAGMRLRVAMCHMIYRKALRLSN 183
A + Y+ +L L+ I+ L + G+RLR A+ M ++K L+L N
Sbjct: 210 --ATESNLQYSLLLVLGLLLTEIVRSWSLALTWALNYRTGVRLRGAILTMAFKKILKLKN 267
Query: 184 MAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAV 243
+ + + G+++N+ SND + + L GP+ AI + +G + G AV
Sbjct: 268 IK--EKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVIILGPTGFLGSAV 325
Query: 244 LIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLR 303
I+ P +L + R K TD R++ MNEV+T I+ IKMYAW K+FS + +R
Sbjct: 326 FILFYPAMMFASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIR 385
Query: 304 KKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRL 363
++E + ++ + + + I VTF+ ++ LG +TA++ F VT++ ++
Sbjct: 386 EEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTF 445
Query: 364 TVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKA 422
+ + P +++ +SEA V++ R ++ L++E+ + P+ + +++ T WD +
Sbjct: 446 ALKV-TPFSVKSLSEASVAVDRFKSLFLMEEVHMIKNK-PASPHIKIEMKNATLAWDSS 502
Score = 89.7 bits (221), Expect = 1e-17
Identities = 113/510 (22%), Positives = 218/510 (42%), Gaps = 29/510 (5%)
Query: 137 YATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVN 196
YA++ ++ IL + +R + ++R+ LR T TG+I+N
Sbjct: 914 YASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILN 973
Query: 197 LLSNDVNKFDQVTVFLHFLWAGPLQ-AIAVTALLWMEIGIS--CLAGMAVLIILLPLQSC 253
S D+ D+V V L F +Q I V + M G+ L + L+IL +
Sbjct: 974 RFSKDM---DEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHI 1030
Query: 254 FGKLFSSLRSKTATFTDARIRT-MNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILR 312
++ + T + + + I G+ I Y + F + L +
Sbjct: 1031 VSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFL 1090
Query: 313 SSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSA 372
+C S ++ T VL+ I + +A++ AV+LT F
Sbjct: 1091 FTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISY--AVQLTGLFQFTVR 1148
Query: 373 IERVSEA-IVSIRRIQTF---LLLDEISQRNRQLPS-DGKKMVHVQDFTAFWDKASETP- 426
+ +EA S+ RI + L L+ ++ + PS D + V A P
Sbjct: 1149 LASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPL 1208
Query: 427 TLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG------------- 473
L+ +SFT++P E + +VG G+GKSSL A+ + S G + + G
Sbjct: 1209 VLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRS 1268
Query: 474 RIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGT 533
+++ + Q+P +FSGT+RSN+ +Y +++ ++ +K+ + L + + + G
Sbjct: 1269 KLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGD 1328
Query: 534 TLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQ 593
S G++ + +ARA+ + I +LD+ +A+D E L + I + + + + H+
Sbjct: 1329 NFSVGERQLLCIARALLRHCKILILDEATAAMDTETDL-LIQETIREAFADCTMLTIAHR 1387
Query: 594 LQYLKAASQILILKDGKMVQKGTYTEFLKS 623
L + + +I++L G++V+ T + L +
Sbjct: 1388 LHTVLGSDRIMVLAQGQVVEFDTPSVLLSN 1417
>gi|134142342 ATP-binding cassette, sub-family C, member 1 isoform 4
[Homo sapiens]
Length = 1416
Score = 240 bits (613), Expect = 4e-63
Identities = 150/520 (28%), Positives = 262/520 (50%), Gaps = 54/520 (10%)
Query: 3 PVYQEV----KPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGE 58
P++ E P P A+ SR+ FWW+ L G+++ LE D++S+ ED S+ +
Sbjct: 196 PLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVP 255
Query: 59 ELQGFWDKEVLRAENDAQK------------------------------------PSLTR 82
L W KE + K PSL +
Sbjct: 256 VLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFK 315
Query: 83 AIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLT 142
+ K + +L+ F I + P L +I + D+ A + + TVL
Sbjct: 316 VLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVN-----DTKAPDWQGYFYTVLL 370
Query: 143 FCTLIL-AILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSND 201
F T L ++ H YF+ +GMR++ A+ +YRKAL ++N A +T G+IVNL+S D
Sbjct: 371 FVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVD 430
Query: 202 VNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSL 261
+F + +++ +W+ PLQ I LLW+ +G S LAG+AV+++++P+ + +
Sbjct: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTY 490
Query: 262 RSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNL 321
+ D RI+ MNE++ GI+++K+YAWE +F + + +R++E+ + +S+ L +
Sbjct: 491 QVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGT 550
Query: 322 ASFFSASKIIVFVTFTTYVLL--GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEA 379
++ ++ TF YV + +++ A FV++ L+ +R + + P I + +A
Sbjct: 551 FTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNI-LPMVISSIVQA 609
Query: 380 IVSIRRIQTFLLLDEIS----QRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTV 435
VS++R++ FL +E+ +R G + V++ T W + S+ PTL G++F++
Sbjct: 610 SVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWAR-SDPPTLNGITFSI 668
Query: 436 RPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRI 475
G L+AVVG VG GKSSLLSA+L E+ G V++ RI
Sbjct: 669 PEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKTRI 708
Score = 92.8 bits (229), Expect = 1e-18
Identities = 81/283 (28%), Positives = 134/283 (47%), Gaps = 44/283 (15%)
Query: 585 KITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLK--------KDNE 636
K ILVTH + YL I+++ GK+ + G+Y E L F L+ +D E
Sbjct: 705 KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAE 764
Query: 637 ESEQPPVPG----TPTLRN-------------RTFSESSVWSQQSSRPSLKDGALESQDT 679
E+ V G + N R S SS +S SR L+ +
Sbjct: 765 ENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEA 824
Query: 680 ENVPV-TLSEENRSE-GKVGFQAYKNYFRAGAHWIVF--IFLILLNTAAQVAYVLQDWWL 735
+ L E ++++ G+V Y +Y +A +I F IFL + N + +A ++WL
Sbjct: 825 KKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALA---SNYWL 881
Query: 736 SYWANKQSMLNVTVNGGGNVTE-KLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSS 794
S W + + VNG T+ +L + LGI G+ V FG + ++ + +L +S
Sbjct: 882 SLWTD-----DPIVNGTQEHTKVRLSVYGALGISQGIAV----FGYSMAVSIGGIL--AS 930
Query: 795 QTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLP 837
+ LH + SIL++P+ FF+R P G ++NRFSK++ +D ++P
Sbjct: 931 RCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIP 973
Score = 83.2 bits (204), Expect = 1e-15
Identities = 106/489 (21%), Positives = 204/489 (41%), Gaps = 32/489 (6%)
Query: 166 LRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPL-QAIA 224
L V + H I R + +T +G +VN S +++ D + + ++ G L I
Sbjct: 933 LHVDLLHSILRSPMSFFE----RTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIG 988
Query: 225 VTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIR 284
++ + I+ + + +I +Q + L+ + NE + G+
Sbjct: 989 ACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVS 1048
Query: 285 IIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSA-SKIIVFVTFTTYVLLG 343
+I+ + ++ F + ++L+ E K S + LA IV V+
Sbjct: 1049 VIRAFEEQERFIHQ-SDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISR 1107
Query: 344 SVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEA---IVSIRRIQTFLLLDEIS--QR 398
++A V ++V+ L VT + + SE IV++ R++ + ++ + Q
Sbjct: 1108 HSLSAGLVGLSVSY----SLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQI 1163
Query: 399 NRQLPSDGKKMVHVQDFTAFWDKASETP--TLQGLSFTVRPGELLAVVGPVGAGKSSLLS 456
P V +F + + E L+ ++ T+ GE + +VG GAGKSSL
Sbjct: 1164 QETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTL 1223
Query: 457 AVLGELAPSHGLVSVHG-------------RIAYVSQQPWVFSGTLRSNILFGKKYEKER 503
+ + G + + G +I + Q P +FSG+LR N+ +Y E
Sbjct: 1224 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEE 1283
Query: 504 YEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLS 563
++ LK + L D + G LS GQ+ V LARA+ + I +LD+ +
Sbjct: 1284 VWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATA 1343
Query: 564 AVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKS 623
AVD E L + I + + + H+L + +++++L G++ + G ++ L+
Sbjct: 1344 AVDLETD-DLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ 1402
Query: 624 GIDFGSLLK 632
F S+ K
Sbjct: 1403 RGLFYSMAK 1411
>gi|221316556 ATP-binding cassette, sub-family C, member 3 isoform 2
[Homo sapiens]
Length = 572
Score = 184 bits (466), Expect = 4e-46
Identities = 102/334 (30%), Positives = 178/334 (53%), Gaps = 30/334 (8%)
Query: 6 QEVKPNPLQD--ANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGF 63
+ V PNP + A SR+FFWW + G++ LEE D++S+ EDRSQ + ++L
Sbjct: 200 KNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEA 259
Query: 64 WDKE-----------------------VLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTL 100
W K+ +L A +KPS +A++ + S+L+ F L
Sbjct: 260 WRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKL 319
Query: 101 IEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQ 160
I++ I P L +I + N PM + A ++ C+++ +++ Y++++
Sbjct: 320 IQDLLSFINPQLLSILIRFISN--PM--APSWWGFLVAGLMFLCSMMQSLILQHYYHYIF 375
Query: 161 CAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPL 220
G++ R + +IYRKAL ++N +T G+IVNL+S D +F + FL+ LW+ PL
Sbjct: 376 VTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPL 435
Query: 221 QAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVI 280
Q I LW +G S LAG+A +++L+PL + + K D+RI+ M+E++
Sbjct: 436 QIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEIL 495
Query: 281 TGIRIIKMYAWEKSFSNLITNLRKKEISKILRSS 314
GI+++K+YAWE SF + +R+ E+ ++LR++
Sbjct: 496 NGIKVLKLYAWEPSFLKQVEGIRQGEL-QLLRTA 528
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 134 bits (337), Expect = 4e-31
Identities = 134/560 (23%), Positives = 249/560 (44%), Gaps = 77/560 (13%)
Query: 110 PIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLIL-------AILHHLYFYHVQCA 162
P FLGKII D + N Y+ LT L L A + + Y +Q +
Sbjct: 189 PFFLGKII---------DVIYTNPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTS 239
Query: 163 GMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQ-VTVFLHF-LWAGPL 220
G R+ + ++ LR KT TG+++N LS+D + VT L L AG
Sbjct: 240 GQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQ 299
Query: 221 QAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVI 280
++ ++ + ++ ++ ++V+ + + +G+ L T + E I
Sbjct: 300 ASVGISMMFFVSPNLATFV-LSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERI 358
Query: 281 TGIRIIKMYAWEKSFSNLITNLRK--KEISKILRSSCLRGMNLASFFSASKIIVFVTFTT 338
+R ++ + E +T + K ++ +++ + A FF A+
Sbjct: 359 GNVRTVRAFGKE------MTEIEKYASKVDHVMQLARKEAFARAGFFGATG--------- 403
Query: 339 YVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLL------- 391
L G++I S ++ L G+ +TV S + +SI + +F
Sbjct: 404 --LSGNLIVLSVLYKGGLLMGSAHMTVGEL-SSFLMYAFWVGISIGGLSSFYSELMKGLG 460
Query: 392 ----LDEISQRNRQLPSDGKKMVHVQDFTAF---------WDKASETPTLQGLSFTVRPG 438
L E+ +R +LP + +++ + F + E P Q S ++ G
Sbjct: 461 AGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSG 520
Query: 439 ELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG-------------RIAYVSQQPWVF 485
+ A+VGP G+GKS++LS +L P+ G +S+ G +I VSQ+P +F
Sbjct: 521 SVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILF 580
Query: 486 SGTLRSNILFG----KKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKA 541
S ++ NI +G E ++V + ++ G TV+G++G LSGGQK
Sbjct: 581 SCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQ 640
Query: 542 RVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAAS 601
R+ +ARA+ ++ I LLD+ SA+DAE + +L + + +++ + +++ H+L +K A+
Sbjct: 641 RIAIARALLKNPKILLLDEATSALDAE-NEYLVQEALDRLMDGRTVLVIAHRLSTIKNAN 699
Query: 602 QILILKDGKMVQKGTYTEFL 621
+ +L GK+ + G + E L
Sbjct: 700 MVAVLDQGKITEYGKHEELL 719
Score = 39.3 bits (90), Expect = 0.016
Identities = 21/59 (35%), Positives = 32/59 (54%), Gaps = 4/59 (6%)
Query: 774 ATVLFGIARSLLVFYVLVNSSQTLHNKM----FESILKAPVLFFDRNPIGRILNRFSKD 828
A L G A + + Y++ S Q + N++ F SIL+ V FFD+ G ++NR S D
Sbjct: 220 AVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSD 278
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 129 bits (325), Expect = 9e-30
Identities = 146/575 (25%), Positives = 257/575 (44%), Gaps = 55/575 (9%)
Query: 92 YLVLGIFTLIEESAKVIQPIF---LGKIINYFENYDPMDSVALNTAYAYATVLTFCTLIL 148
Y V+G+F I +QP F KII F D ++ N+ ++ + +I
Sbjct: 710 YFVVGVFCAIINGG--LQPAFAIIFSKIIGVFTRIDDPETKRQNSNL-FSLLFLALGIIS 766
Query: 149 AILHHLYFYHVQCAGMRLRVAMCHMIYRKALR--LSNMAMGKTTTGQIVNLLSNDVNKFD 206
I L + AG L + +M++R LR +S K TTG + L+ND
Sbjct: 767 FITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAA--- 823
Query: 207 QVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILL---PLQSCFG----KLFS 259
QV + A Q IA L I IS + G + ++LL P+ + G K+ S
Sbjct: 824 QVKGAIGSRLAVITQNIAN---LGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLS 880
Query: 260 SLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGM 319
K + + E I R + E+ F ++ + LR + + G+
Sbjct: 881 GQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGI 940
Query: 320 NLASFFSASKIIVFVTFTTYVLLGSVITASR---------VFVAVTLYGAVRL-TVTLFF 369
FS ++ +++ ++ G+ + A + VF AV ++GA+ + V+ F
Sbjct: 941 T----FSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAV-VFGAMAVGQVSSFA 995
Query: 370 PSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQ 429
P + A I I+ L+D S +P+ + V + + + P LQ
Sbjct: 996 PDYAKAKISAAHIIMIIEKTPLIDSYSTEGL-MPNTLEGNVTFGEVVFNYPTRPDIPVLQ 1054
Query: 430 GLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGR-------------IA 476
GLS V+ G+ LA+VG G GKS+++ + P G V + G+ +
Sbjct: 1055 GLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLG 1114
Query: 477 YVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACA---LKKDLQLLEDGDLTVIGDRGT 533
VSQ+P +F ++ NI +G E++++A + ++ L + T +GD+GT
Sbjct: 1115 IVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGT 1174
Query: 534 TLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQ 593
LSGGQK R+ +ARA+ + I LLD+ SA+D E S + + + + + I++ H+
Sbjct: 1175 QLSGGQKQRIAIARALVRQPHILLLDEATSALDTE-SEKVVQEALDKAREGRTCIVIAHR 1233
Query: 594 LQYLKAASQILILKDGKMVQKGTYTEFL-KSGIDF 627
L ++ A I++ ++G++ + GT+ + L + GI F
Sbjct: 1234 LSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYF 1268
Score = 122 bits (306), Expect = 1e-27
Identities = 183/840 (21%), Positives = 347/840 (41%), Gaps = 121/840 (14%)
Query: 70 RAENDAQKPSLTRAIIKCY----W--KSYLVLGIFTLIEESAKV-IQPIFLGKIINYFEN 122
++E D ++ T ++ + W K Y+V+G I A + + + G++ + F N
Sbjct: 22 KSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFAN 81
Query: 123 YDPMDSVALN--------------------TAYAYATVLTFCTLILAILHHLYFYHVQCA 162
++ + N T YAY +++A + F+ +
Sbjct: 82 AGNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAG 141
Query: 163 GM--RLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKF-----DQVTVFLHFL 215
++R H I R+ + ++ G++ L++DV+K D++ +F +
Sbjct: 142 RQIHKIRKQFFHAIMRQEIGWFDVH----DVGELNTRLTDDVSKINEGIGDKIGMFFQSM 197
Query: 216 WAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARI-- 273
A + + G + +++L + G + ++FTD +
Sbjct: 198 -----------ATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLA 246
Query: 274 -----RTMNEVITGIRIIKMYAWEKS----FSNLITNLRKKEISKILRSSCLRGMNLASF 324
EV+ IR + + +K ++ + ++ I K + ++ G
Sbjct: 247 YAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLI 306
Query: 325 FSASKIIVFVTFTTYVLLG--SVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVS 382
+ AS + F TT VL G S+ VF +V L GA + A A
Sbjct: 307 Y-ASYALAFWYGTTLVLSGEYSIGQVLTVFFSV-LIGAFSVGQASPSIEAFANARGAAYE 364
Query: 383 IRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLA 442
I +I + ++ P + K + ++ + E L+GL+ V+ G+ +A
Sbjct: 365 IFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVA 424
Query: 443 VVGPVGAGKSSLLSAVLGELAPSHGLVSVHGR-------------IAYVSQQPWVFSGTL 489
+VG G GKS+ + + P+ G+VSV G+ I VSQ+P +F+ T+
Sbjct: 425 LVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTI 484
Query: 490 RSNILFGKK-YEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARA 548
NI +G++ + EK +K + L T++G+RG LSGGQK R+ +ARA
Sbjct: 485 AENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARA 544
Query: 549 VYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKD 608
+ ++ I LLD+ SA+D E S + ++ + + + TI++ H+L ++ A I D
Sbjct: 545 LVRNPKILLLDEATSALDTE-SEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDD 603
Query: 609 GKMVQKGTYTEFLK-SGIDF--------GSLLKKDNEESEQPPVPGTPTLRNRTFSESSV 659
G +V+KG + E +K GI F G+ ++ +N E + + S SS+
Sbjct: 604 GVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSND-SRSSL 662
Query: 660 WSQQSSRPSLKDGALESQDTENVPVTLSEENRSEGKVGF-QAYKNYFRAGAHWIVFIFLI 718
++S+R S++ SQ + T + S V F + K +++V +F
Sbjct: 663 IRKRSTRRSVRG----SQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCA 718
Query: 719 LLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWY------LGIYSGLT 772
++N Q A+ + ++ V T++ + N + LGI S +T
Sbjct: 719 IINGGLQPAFAI---------IFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFIT 769
Query: 773 --VATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFD--RNPIGRILNRFSKD 828
+ FG A +L ++ L +F S+L+ V +FD +N G + R + D
Sbjct: 770 FFLQGFTFGKAGEIL--------TKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLAND 821
>gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo
sapiens]
Length = 718
Score = 129 bits (325), Expect = 9e-30
Identities = 141/604 (23%), Positives = 264/604 (43%), Gaps = 63/604 (10%)
Query: 86 KCYWK----SYLVLGIFTLIEESAKVIQ---PIFLGKIINYFENYDPMDSVA--LNTAYA 136
K +W+ LVLG+ ++ A ++ P+ LG+++ Y D V + +
Sbjct: 118 KLFWQFLHPHLLVLGVAVVLALGAALVNVQIPLLLGQLVEVVAKYT-RDHVGSFMTESQN 176
Query: 137 YATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVN 196
+T L + +L Y + G R+ V M ++ LR TGQ+V+
Sbjct: 177 LSTHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVS 236
Query: 197 LLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGK 256
L+ DV +F + F + G V L + +S L+ L++++ + G
Sbjct: 237 RLTTDVQEFK--SSFKLVISQGLRSCTQVAGCL---VSLSMLSTRLTLLLMVATPALMGV 291
Query: 257 ---LFSSLRSKTATFTDARIRTM---NEVITGIRIIKMYAWEKSFSNLITNLRKKEISKI 310
+ S LR + + R M +E + +R ++ +A E+ R++E
Sbjct: 292 GTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQ---------REEERYGA 342
Query: 311 LRSSCL-----RGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTV 365
+C G +A F S I + +G + A + L + +
Sbjct: 343 ELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQ 402
Query: 366 TLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMV---HVQDFTAFWDKA 422
T+ A V V +R + + E N +P G V ++ F +
Sbjct: 403 TVQRSMANLSVLFGQV-VRGLSAGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVC 461
Query: 423 SETP------TLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGR-- 474
P L+ + T+ PG+++A+VG G GK+++ S + P+ G+V + GR
Sbjct: 462 FSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDL 521
Query: 475 ------------IAYVSQQPWVFSGTLRSNILFGK--KYEKERYEKVIKACALKKDLQLL 520
+ ++SQ+P +F T+ NI FGK ++E Y +A A + +
Sbjct: 522 RTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREANA-HEFITSF 580
Query: 521 EDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQ 580
+G TV+G+RGTTLSGGQK R+ +ARA+ + + +LD+ SA+DAE S + + + +
Sbjct: 581 PEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAE-SERVVQEALDR 639
Query: 581 ILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQ 640
+ +++ H+L ++ A I+++ DG++ + GT+ E LK G + L+++ ++ +
Sbjct: 640 ASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIRRQALDAPR 699
Query: 641 PPVP 644
P
Sbjct: 700 TAAP 703
Score = 34.3 bits (77), Expect = 0.51
Identities = 21/78 (26%), Positives = 42/78 (53%), Gaps = 3/78 (3%)
Query: 752 GGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVL 811
G +TE +L+ +L I G+ + FG +L+ +V + + +F S+L+ +
Sbjct: 168 GSFMTESQNLSTHLLILYGVQ-GLLTFGYL--VLLSHVGERMAVDMRRALFSSLLRQDIT 224
Query: 812 FFDRNPIGRILNRFSKDI 829
FFD N G++++R + D+
Sbjct: 225 FFDANKTGQLVSRLTTDV 242
>gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 128 bits (322), Expect = 2e-29
Identities = 131/571 (22%), Positives = 257/571 (45%), Gaps = 44/571 (7%)
Query: 91 SYLVLGIFTLIEES-AKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILA 149
++LV F LI + + P + G+ I+ MD +TA +L + A
Sbjct: 186 AFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQ--FSTAVVIVCLLAIGSSFAA 243
Query: 150 ILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQ-- 207
+ F + RL + + + ++R + + TG +++ L++D
Sbjct: 244 GIRGGIFTLIFA---RLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLV 300
Query: 208 ---VTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSK 264
+ VFL + + +L W +S + M II++ + + +GK + L +
Sbjct: 301 SQNINVFLRNTVKVTGVVVFMFSLSWQ---LSLVTFMGFPIIMM-VSNIYGKYYKRLSKE 356
Query: 265 TATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRK-KEISKILRSSCLRGMNLAS 323
T E I+ ++ ++ +A E+ + + LRK +++ K+ R M
Sbjct: 357 VQNALARASNTAEETISAMKTVRSFANEEEEAEVY--LRKLQQVYKLNRKEAAAYMYYVW 414
Query: 324 FFSASKIIVFVTFTTY----VLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEA 379
+ ++V V+ Y V+ G + + + +A +Y V S + +
Sbjct: 415 GSGLTLLVVQVSILYYGGHLVISGQMTSGN--LIAFIIYEFVLGDCMESVGSVYSGLMQG 472
Query: 380 IVSIRRIQTFLLLDEISQRNRQLPSDGKK-MVHVQDFTAFWDKASETPTLQGLSFTVRPG 438
+ + ++ F+ + L D + V ++ T + T LQ +SF++ PG
Sbjct: 473 VGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPG 532
Query: 439 ELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGR-------------IAYVSQQPWVF 485
++ A+VGP G+GKSS ++ + G V + G+ I+ VSQ+P +F
Sbjct: 533 KVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLF 592
Query: 486 SGTLRSNILFGKKYEKERYEKVIKACALKKD---LQLLEDGDLTVIGDRGTTLSGGQKAR 542
+ ++ NI +G +E V++A + L+DG T G++G LSGGQK R
Sbjct: 593 ARSITDNISYG--LPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQR 650
Query: 543 VNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQ 602
V +ARA+ ++ + +LD+ SA+DAE S +L + I L + +++ H+L ++ A
Sbjct: 651 VAMARALVRNPPVLILDEATSALDAE-SEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHL 709
Query: 603 ILILKDGKMVQKGTYTEFLKSGIDFGSLLKK 633
I++L G++VQ+GT+ + L G + L+++
Sbjct: 710 IVVLDKGRVVQQGTHQQLLAQGGLYAKLVQR 740
Score = 30.4 bits (67), Expect = 7.3
Identities = 13/40 (32%), Positives = 22/40 (55%)
Query: 797 LHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLL 836
L N +F S++ FFD N G +++R + D + DL+
Sbjct: 261 LRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLV 300
>gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 128 bits (322), Expect = 2e-29
Identities = 131/571 (22%), Positives = 257/571 (45%), Gaps = 44/571 (7%)
Query: 91 SYLVLGIFTLIEES-AKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILA 149
++LV F LI + + P + G+ I+ MD +TA +L + A
Sbjct: 186 AFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQ--FSTAVVIVCLLAIGSSFAA 243
Query: 150 ILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQ-- 207
+ F + RL + + + ++R + + TG +++ L++D
Sbjct: 244 GIRGGIFTLIFA---RLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLV 300
Query: 208 ---VTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSK 264
+ VFL + + +L W +S + M II++ + + +GK + L +
Sbjct: 301 SQNINVFLRNTVKVTGVVVFMFSLSWQ---LSLVTFMGFPIIMM-VSNIYGKYYKRLSKE 356
Query: 265 TATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRK-KEISKILRSSCLRGMNLAS 323
T E I+ ++ ++ +A E+ + + LRK +++ K+ R M
Sbjct: 357 VQNALARASNTAEETISAMKTVRSFANEEEEAEVY--LRKLQQVYKLNRKEAAAYMYYVW 414
Query: 324 FFSASKIIVFVTFTTY----VLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEA 379
+ ++V V+ Y V+ G + + + +A +Y V S + +
Sbjct: 415 GSGLTLLVVQVSILYYGGHLVISGQMTSGN--LIAFIIYEFVLGDCMESVGSVYSGLMQG 472
Query: 380 IVSIRRIQTFLLLDEISQRNRQLPSDGKK-MVHVQDFTAFWDKASETPTLQGLSFTVRPG 438
+ + ++ F+ + L D + V ++ T + T LQ +SF++ PG
Sbjct: 473 VGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPG 532
Query: 439 ELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGR-------------IAYVSQQPWVF 485
++ A+VGP G+GKSS ++ + G V + G+ I+ VSQ+P +F
Sbjct: 533 KVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLF 592
Query: 486 SGTLRSNILFGKKYEKERYEKVIKACALKKD---LQLLEDGDLTVIGDRGTTLSGGQKAR 542
+ ++ NI +G +E V++A + L+DG T G++G LSGGQK R
Sbjct: 593 ARSITDNISYG--LPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQR 650
Query: 543 VNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQ 602
V +ARA+ ++ + +LD+ SA+DAE S +L + I L + +++ H+L ++ A
Sbjct: 651 VAMARALVRNPPVLILDEATSALDAE-SEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHL 709
Query: 603 ILILKDGKMVQKGTYTEFLKSGIDFGSLLKK 633
I++L G++VQ+GT+ + L G + L+++
Sbjct: 710 IVVLDKGRVVQQGTHQQLLAQGGLYAKLVQR 740
Score = 30.4 bits (67), Expect = 7.3
Identities = 13/40 (32%), Positives = 22/40 (55%)
Query: 797 LHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLL 836
L N +F S++ FFD N G +++R + D + DL+
Sbjct: 261 LRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLV 300
>gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo
sapiens]
Length = 842
Score = 122 bits (307), Expect = 1e-27
Identities = 144/610 (23%), Positives = 266/610 (43%), Gaps = 70/610 (11%)
Query: 78 PSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALN-TAYA 136
P+L ++ C LG+ L E + V+ PIF I+N P +S+A T+Y
Sbjct: 259 PALQLVVLIC-------LGLMGL-ERALNVLVPIFYRNIVNLLTEKAPWNSLAWTVTSYV 310
Query: 137 YATVL----TFCTLILAILHHLYFYHVQ-CAGMRLRVAMCHMIYRKALRLSNMAMGKTTT 191
+ L T T ++ L + VQ R+ + + ++ +LR +G+ T
Sbjct: 311 FLKFLQGGGTGSTGFVSNLRTFLWIRVQQFTSRRVELLIFSHLHELSLRWH---LGRRT- 366
Query: 192 GQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIIL---L 248
G+++ + + + +L F P A + +++ + + G+ V + + L
Sbjct: 367 GEVLRIADRGTSSVTGLLSYLVFNVI-PTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYL 425
Query: 249 PLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEIS 308
L + + R T +A + + +K Y N E+
Sbjct: 426 TLTIVVTEWRTKFRRAMNTQENATRARAVDSLLNFETVKYY-----------NAESYEVE 474
Query: 309 KILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSV---------ITASRVFVA-VTLY 358
+ R + ++ L SAS +++ T + LG + +T ++ V L+
Sbjct: 475 RY-REAIIKYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGDYVLF 533
Query: 359 GA--VRLTVTL-FFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGK---KMVHV 412
G ++L + L +F + + + + + F LL E ++ + LP G + +
Sbjct: 534 GTYIIQLYMPLNWFGTYYRMIQTNFIDMENM--FDLLKEETEV-KDLPGAGPLRFQKGRI 590
Query: 413 QDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVH 472
+ + A TLQ +SFTV PG+ LA+VGP GAGKS++L + S G + +
Sbjct: 591 EFENVHFSYADGRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRID 650
Query: 473 GR-------------IAYVSQQPWVFSGTLRSNILFGKKYE-KERYEKVIKACALKKDLQ 518
G+ I V Q +F+ T+ NI +G+ + E +A + +
Sbjct: 651 GQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDAIM 710
Query: 519 LLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCI 578
+G T +G+RG LSGG+K RV +AR + + I LLD+ SA+D R + + +
Sbjct: 711 AFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAI-QASL 769
Query: 579 CQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSL--LKKDNE 636
++ + TI+V H+L + A QIL++KDG +V++G + L G + + L++ E
Sbjct: 770 AKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQE 829
Query: 637 ESEQPPVPGT 646
E+ + P T
Sbjct: 830 ETSEDTKPQT 839
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 121 bits (304), Expect = 2e-27
Identities = 133/541 (24%), Positives = 241/541 (44%), Gaps = 68/541 (12%)
Query: 175 YRKALRLSNMAMGKTTTGQIVNLLSNDVNKF-----DQVTVFLHFLWAGPLQAIAVTALL 229
+R+ +R+ + G++ S+D+NK DQ+ +F+ Q + T
Sbjct: 179 FRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFI--------QRMTSTICG 230
Query: 230 WMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTM-------NEVITG 282
++ + G + ++++ + G +++ + FTD ++ +EVI+
Sbjct: 231 FL---LGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISS 287
Query: 283 IRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLL 342
+R + + EK +K + R +G+ + F ++F+ +
Sbjct: 288 MRTVAAFGGEKRE----VERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWY 343
Query: 343 GSVI----------TASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSI-RRIQTFLL 391
GS + T ++F++V + GA+ L A A SI I +
Sbjct: 344 GSTLVLDEGEYTPGTLVQIFLSV-IVGALNLGNASPCLEAFATGRAAATSIFETIDRKPI 402
Query: 392 LDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGK 451
+D +S+ +L K + + T + E L L+ ++PGE+ A+VGP GAGK
Sbjct: 403 IDCMSEDGYKLDRI-KGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGK 461
Query: 452 SSLLSAVLGELAPSHGLVSVHG-------------RIAYVSQQPWVFSGTLRSNILFGKK 498
S+ L + P G+V+V G +I V Q+P +FS T+ NI +G+
Sbjct: 462 STALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGR- 520
Query: 499 YEKERYEKVIKAC----ALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDAD 554
E E +++A A + L + D T++G+ G +SGGQK RV +ARA+ ++
Sbjct: 521 -EDATMEDIVQAAKEANAYNFIMDLPQQFD-TLVGEGGGQMSGGQKQRVAIARALIRNPK 578
Query: 555 IYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQK 614
I LLD SA+D E S + + + +I H I V H+L ++AA I+ + G V++
Sbjct: 579 ILLLDMATSALDNE-SEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVER 637
Query: 615 GTYTEFL-KSGIDFG--SLLKKDNEESEQPPVPGT--PTLRNRTFSESSVWSQQSSRPSL 669
GT+ E L + G+ F +L + N+ + + + RTFS S Q S R S+
Sbjct: 638 GTHEELLERKGVYFTLVTLQSQGNQALNEEDIKDATEDDMLARTFSRGSY--QDSLRASI 695
Query: 670 K 670
+
Sbjct: 696 R 696
Score = 106 bits (264), Expect = 1e-22
Identities = 98/376 (26%), Positives = 172/376 (45%), Gaps = 43/376 (11%)
Query: 277 NEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVT- 335
NE ++ IR + E+ F + +K ++ + + G F+ ++ I+F+
Sbjct: 941 NEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYGF----CFAFAQCIMFIAN 996
Query: 336 -----FTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFL 390
+ Y++ + S VF ++ AV L+ T + S A I + F
Sbjct: 997 SASYRYGGYLISNEGLHFSYVFRVIS---AVVLSATALGRAFSYTPSYAKAKISAARFFQ 1053
Query: 391 LLDE---ISQRNRQLPSDGKKMVHVQDFTAFWD------KASETPTLQGLSFTVRPGELL 441
LLD IS N + G+K + Q F D ++ L GLS ++ PG+ L
Sbjct: 1054 LLDRQPPISVYN----TAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTL 1109
Query: 442 AVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGR-------------IAYVSQQPWVFSGT 488
A VG G GKS+ + + P G V + G I VSQ+P +F+ +
Sbjct: 1110 AFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACS 1169
Query: 489 LRSNILFGKKYEKERYEKVI---KACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNL 545
+ NI +G ++ E+VI K L + L + T +G +G+ LS G+K R+ +
Sbjct: 1170 IMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAI 1229
Query: 546 ARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILI 605
ARA+ +D I LLD+ SA+D E S ++ + + + I++ H+L ++ A I +
Sbjct: 1230 ARAIVRDPKILLLDEATSALDTE-SEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAV 1288
Query: 606 LKDGKMVQKGTYTEFL 621
+ G +++KGT+ E +
Sbjct: 1289 MAQGVVIEKGTHEELM 1304
Score = 45.8 bits (107), Expect = 2e-04
Identities = 30/121 (24%), Positives = 54/121 (44%), Gaps = 3/121 (2%)
Query: 738 WANKQSMLNVTVNGG--GNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQ 795
W N N+T NG G + + ++ + Y+G+ VA ++ G + Q
Sbjct: 114 WTNSSLNQNMT-NGTRCGLLNIESEMIKFASYYAGIAVAVLITGYIQICFWVIAAARQIQ 172
Query: 796 TLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQRWDLAVLSWL 855
+ F I++ + +FD N +G + RFS DI ++D + FIQR + +L
Sbjct: 173 KMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFL 232
Query: 856 V 856
+
Sbjct: 233 L 233
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.137 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,134,522
Number of Sequences: 37866
Number of extensions: 1216437
Number of successful extensions: 3623
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 78
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 3227
Number of HSP's gapped (non-prelim): 188
length of query: 859
length of database: 18,247,518
effective HSP length: 111
effective length of query: 748
effective length of database: 14,044,392
effective search space: 10505205216
effective search space used: 10505205216
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.