Search of human proteins with 156105685

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo
sapiens]
         (718 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo ...  1417   0.0  
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo...   421   e-118
gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member ...   367   e-101
gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member...   367   e-101
gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member ...   333   3e-91
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa...   325   9e-89
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member...   322   6e-88
gi|73747915 transporter 2, ATP-binding cassette, sub-family B is...   319   5e-87
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B...   318   1e-86
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C...   318   1e-86
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A...   318   1e-86
gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Ho...   301   1e-81
gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ...   290   4e-78
gi|73747917 transporter 2, ATP-binding cassette, sub-family B is...   286   6e-77
gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo sa...   238   1e-62
gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo s...   199   1e-50
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ...   164   3e-40
gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor...   155   9e-38
gi|134142342 ATP-binding cassette, sub-family C, member 1 isofor...   155   9e-38
gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor...   155   9e-38
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor...   155   9e-38
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member...   154   3e-37
gi|110832837 ATP-binding cassette, sub-family C, member 9 isofor...   148   2e-35
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ...   145   1e-34
gi|110832839 ATP-binding cassette, sub-family C, member 9 isofor...   144   2e-34
gi|110832835 ATP-binding cassette, sub-family C, member 9 isofor...   144   2e-34
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor...   139   9e-33
gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo ...   139   1e-32
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform...   138   2e-32
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]           135   1e-31

>gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo
           sapiens]
          Length = 718

 Score = 1417 bits (3668), Expect = 0.0
 Identities = 718/718 (100%), Positives = 718/718 (100%)

Query: 1   MLVHLFRVGIRGGPFPGRLLPPLRFQTFSAVRYSDGYRSSSLLRAVAHLRSQLWAHLPRA 60
           MLVHLFRVGIRGGPFPGRLLPPLRFQTFSAVRYSDGYRSSSLLRAVAHLRSQLWAHLPRA
Sbjct: 1   MLVHLFRVGIRGGPFPGRLLPPLRFQTFSAVRYSDGYRSSSLLRAVAHLRSQLWAHLPRA 60

Query: 61  PLAPRWSPSAWCWVGGALLGPMVLSKHPHLCLVALCEAEEAPPASSTPHVVGSRFNWKLF 120
           PLAPRWSPSAWCWVGGALLGPMVLSKHPHLCLVALCEAEEAPPASSTPHVVGSRFNWKLF
Sbjct: 61  PLAPRWSPSAWCWVGGALLGPMVLSKHPHLCLVALCEAEEAPPASSTPHVVGSRFNWKLF 120

Query: 121 WQFLHPHLLVLGVAVVLALGAALVNVQIPLLLGQLVEVVAKYTRDHVGSFMTESQNLSTH 180
           WQFLHPHLLVLGVAVVLALGAALVNVQIPLLLGQLVEVVAKYTRDHVGSFMTESQNLSTH
Sbjct: 121 WQFLHPHLLVLGVAVVLALGAALVNVQIPLLLGQLVEVVAKYTRDHVGSFMTESQNLSTH 180

Query: 181 LLILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSRLTT 240
           LLILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSRLTT
Sbjct: 181 LLILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSRLTT 240

Query: 241 DVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGSGLR 300
           DVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGSGLR
Sbjct: 241 DVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGSGLR 300

Query: 301 KLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIAL 360
           KLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIAL
Sbjct: 301 KLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIAL 360

Query: 361 FQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMANLSVLFGQVVR 420
           FQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMANLSVLFGQVVR
Sbjct: 361 FQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMANLSVLFGQVVR 420

Query: 421 GLSAGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTL 480
           GLSAGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTL
Sbjct: 421 GLSAGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTL 480

Query: 481 PPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQE 540
           PPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQE
Sbjct: 481 PPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQE 540

Query: 541 PVLFGTTIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQK 600
           PVLFGTTIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQK
Sbjct: 541 PVLFGTTIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQK 600

Query: 601 QRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAH 660
           QRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAH
Sbjct: 601 QRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAH 660

Query: 661 CIVVMADGRVWEAGTHEELLKKGGLYAELIRRQALDAPRTAAPPPKKPEGPRSHQHKS 718
           CIVVMADGRVWEAGTHEELLKKGGLYAELIRRQALDAPRTAAPPPKKPEGPRSHQHKS
Sbjct: 661 CIVVMADGRVWEAGTHEELLKKGGLYAELIRRQALDAPRTAAPPPKKPEGPRSHQHKS 718


>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
           sapiens]
          Length = 738

 Score =  421 bits (1083), Expect = e-118
 Identities = 232/575 (40%), Positives = 357/575 (62%), Gaps = 10/575 (1%)

Query: 125 HPHLLVLGVAVVLALGAALVNVQIPLLLGQLVEVV-AKYTRDHVGSFMTESQNLSTHLLI 183
           +P    L  AV     ++++++  P  LG++++V+    T D+  +       LS   L 
Sbjct: 165 YPERRRLAAAVGFLTMSSVISMSAPFFLGKIIDVIYTNPTVDYSDNLTRLCLGLSAVFLC 224

Query: 184 LYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQ 243
                 +  +    L+   G+R+   +R +LFSS+LRQ++ FFD  +TG+L++RL++D  
Sbjct: 225 GAAANAIRVY----LMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTA 280

Query: 244 EFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLS 303
               S    +S GLR+  Q +  +  +  +S  L   ++   P +  +  + G  LRKL+
Sbjct: 281 LLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLT 340

Query: 304 RQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQG 363
           +  Q+ +A+A  +A+E +GNVRTVRAF  E  E E+Y ++++     A +     A F G
Sbjct: 341 KVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFG 400

Query: 364 LSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLS 423
            + ++ N +VL  L+ GG L+    +T G+L SFL+ +  V  S+  LS  + ++++GL 
Sbjct: 401 ATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLG 460

Query: 424 AGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPG 483
           AG R++E +   P +P + G  + ++  +G++ F+NV F+YP RP   + +DF+L++P G
Sbjct: 461 AGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSG 520

Query: 484 KIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVL 543
            + ALVG SG GK+TV SLL R YDP +G + LDG D+R L+P WLR + +G +SQEP+L
Sbjct: 521 SVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSK-IGTVSQEPIL 579

Query: 544 FGTTIMENIRFGKLEASD---EEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQK 600
           F  +I ENI +G  + S    EE+   A  ANA  FI +FP+G+NTVVGE+G  LSGGQK
Sbjct: 580 FSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQK 639

Query: 601 QRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAH 660
           QR+AIARAL+K P +L+LDEATSALDAE+E +VQEALDR   GRTVLVIAHRLST++ A+
Sbjct: 640 QRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNAN 699

Query: 661 CIVVMADGRVWEAGTHEELLKK-GGLYAELIRRQA 694
            + V+  G++ E G HEELL K  G+Y +L+ +Q+
Sbjct: 700 MVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQS 734


>gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member 9
           isoform 1 [Homo sapiens]
          Length = 766

 Score =  367 bits (941), Expect = e-101
 Identities = 220/603 (36%), Positives = 342/603 (56%), Gaps = 11/603 (1%)

Query: 94  ALCEAEEAPPASSTPHVVGSRFNWKLFWQFLHPHLLVLGVAVVLALGAALVNVQIPLLLG 153
           A  EAE  P +   P    S    +    +  P +  L  A    + AAL    +P   G
Sbjct: 151 AATEAEGFPGSGRPPPEQASGATLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTG 210

Query: 154 QLVE-VVAKYTRDHVGSFMTESQNLSTHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRR 212
           + ++ +V + + D   + +     L+       G++G    G   L+     R+ + +R 
Sbjct: 211 RAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRG----GIFTLIF---ARLNIRLRN 263

Query: 213 ALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSM 272
            LF SL+ Q+ +FFD N+TG L+SRLT+D           I+  LR+  +V G +V +  
Sbjct: 264 CLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFS 323

Query: 273 LSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAM 332
           LS +L+L+  +  P +M V  + G   ++LS++ Q  +ARA   A+E +  ++TVR+FA 
Sbjct: 324 LSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFAN 383

Query: 333 EQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGG 392
           E+ E E Y  +L+       +       +   S +    + +  L+ GG LV   Q+T G
Sbjct: 384 EEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSG 443

Query: 393 DLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQLR 452
           +L++F++    +   M ++  ++  +++G+ A  +VFE++   P +   G   +  + L 
Sbjct: 444 NLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGS--LAPDHLE 501

Query: 453 GSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAG 512
           G V F+NV F+Y  RP  +VL++ + +L PGK+ ALVG SG GK++  ++LE FY    G
Sbjct: 502 GRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGG 561

Query: 513 VVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREAN 572
            V+LDG+ +   D  +L  +V+  +SQEPVLF  +I +NI +G      E V  AA++AN
Sbjct: 562 RVLLDGKPISAYDHKYLH-RVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKAN 620

Query: 573 AHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERV 632
           AH FI    +GY+T  GE+G  LSGGQKQR+A+ARAL++ P VLILDEATSALDAESE +
Sbjct: 621 AHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYL 680

Query: 633 VQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIRR 692
           +Q+A+       TVL+IAHRLSTV  AH IVV+  GRV + GTH++LL +GGLYA+L++R
Sbjct: 681 IQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQR 740

Query: 693 QAL 695
           Q L
Sbjct: 741 QML 743


>gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member 9
           isoform 1 [Homo sapiens]
          Length = 766

 Score =  367 bits (941), Expect = e-101
 Identities = 220/603 (36%), Positives = 342/603 (56%), Gaps = 11/603 (1%)

Query: 94  ALCEAEEAPPASSTPHVVGSRFNWKLFWQFLHPHLLVLGVAVVLALGAALVNVQIPLLLG 153
           A  EAE  P +   P    S    +    +  P +  L  A    + AAL    +P   G
Sbjct: 151 AATEAEGFPGSGRPPPEQASGATLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTG 210

Query: 154 QLVE-VVAKYTRDHVGSFMTESQNLSTHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRR 212
           + ++ +V + + D   + +     L+       G++G    G   L+     R+ + +R 
Sbjct: 211 RAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRG----GIFTLIF---ARLNIRLRN 263

Query: 213 ALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSM 272
            LF SL+ Q+ +FFD N+TG L+SRLT+D           I+  LR+  +V G +V +  
Sbjct: 264 CLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFS 323

Query: 273 LSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAM 332
           LS +L+L+  +  P +M V  + G   ++LS++ Q  +ARA   A+E +  ++TVR+FA 
Sbjct: 324 LSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFAN 383

Query: 333 EQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGG 392
           E+ E E Y  +L+       +       +   S +    + +  L+ GG LV   Q+T G
Sbjct: 384 EEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSG 443

Query: 393 DLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQLR 452
           +L++F++    +   M ++  ++  +++G+ A  +VFE++   P +   G   +  + L 
Sbjct: 444 NLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGS--LAPDHLE 501

Query: 453 GSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAG 512
           G V F+NV F+Y  RP  +VL++ + +L PGK+ ALVG SG GK++  ++LE FY    G
Sbjct: 502 GRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGG 561

Query: 513 VVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREAN 572
            V+LDG+ +   D  +L  +V+  +SQEPVLF  +I +NI +G      E V  AA++AN
Sbjct: 562 RVLLDGKPISAYDHKYLH-RVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKAN 620

Query: 573 AHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERV 632
           AH FI    +GY+T  GE+G  LSGGQKQR+A+ARAL++ P VLILDEATSALDAESE +
Sbjct: 621 AHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYL 680

Query: 633 VQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIRR 692
           +Q+A+       TVL+IAHRLSTV  AH IVV+  GRV + GTH++LL +GGLYA+L++R
Sbjct: 681 IQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQR 740

Query: 693 QAL 695
           Q L
Sbjct: 741 QML 743


>gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member 9
           isoform 2 [Homo sapiens]
          Length = 723

 Score =  333 bits (854), Expect = 3e-91
 Identities = 215/603 (35%), Positives = 327/603 (54%), Gaps = 54/603 (8%)

Query: 94  ALCEAEEAPPASSTPHVVGSRFNWKLFWQFLHPHLLVLGVAVVLALGAALVNVQIPLLLG 153
           A  EAE  P +   P    S    +    +  P +  L  A    + AAL    +P   G
Sbjct: 151 AATEAEGFPGSGRPPPEQASGATLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTG 210

Query: 154 QLVE-VVAKYTRDHVGSFMTESQNLSTHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRR 212
           + ++ +V + + D   + +     L+       G++G    G   L+     R+ + +R 
Sbjct: 211 RAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRG----GIFTLIF---ARLNIRLRN 263

Query: 213 ALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSM 272
            LF SL+ Q+ +FFD N+TG L+SRLT+D           I+  LR+  +V G +V +  
Sbjct: 264 CLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFS 323

Query: 273 LSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAM 332
           LS +L+L+  +  P +M V  + G   ++LS++ Q  +ARA   A+E +  ++TVR+FA 
Sbjct: 324 LSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFAN 383

Query: 333 EQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGG 392
           E+ E E Y  +L+    +  +L R  A        A+   V G+  +G            
Sbjct: 384 EEEEAEVYLRKLQ----QVYKLNRKEAA-------AYMYYVWGSGSVGS----------- 421

Query: 393 DLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQLR 452
                                ++  +++G+ A  +VFE++   P +   G   +  + L 
Sbjct: 422 ---------------------VYSGLMQGVGAAEKVFEFIDRQPTMVHDGS--LAPDHLE 458

Query: 453 GSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAG 512
           G V F+NV F+Y  RP  +VL++ + +L PGK+ ALVG SG GK++  ++LE FY    G
Sbjct: 459 GRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGG 518

Query: 513 VVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREAN 572
            V+LDG+ +   D  +L  +V+  +SQEPVLF  +I +NI +G      E V  AA++AN
Sbjct: 519 RVLLDGKPISAYDHKYLH-RVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKAN 577

Query: 573 AHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERV 632
           AH FI    +GY+T  GE+G  LSGGQKQR+A+ARAL++ P VLILDEATSALDAESE +
Sbjct: 578 AHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYL 637

Query: 633 VQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIRR 692
           +Q+A+       TVL+IAHRLSTV  AH IVV+  GRV + GTH++LL +GGLYA+L++R
Sbjct: 638 IQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQR 697

Query: 693 QAL 695
           Q L
Sbjct: 698 QML 700


>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
            sapiens]
          Length = 1280

 Score =  325 bits (833), Expect = 9e-89
 Identities = 213/588 (36%), Positives = 320/588 (54%), Gaps = 22/588 (3%)

Query: 120  FWQFLHPHLLVLGVAVVLALGAALVNVQIPLLLGQLVEVVAKYTRDHVGSFMTESQNLST 179
            FW+ +  +L      VV    A +     P       +++  +TR        ++ NL +
Sbjct: 697  FWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFS 756

Query: 180  HLLILYGVQGLLTF---GYLVLLSHVGERMAVDMRRALFSSLLRQDITFFD--ANKTGQL 234
             L +  G+   +TF   G+       GE +   +R  +F S+LRQD+++FD   N TG L
Sbjct: 757  LLFLALGIISFITFFLQGFT--FGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGAL 814

Query: 235  VSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTL 294
             +RL  D  + K +    ++   ++   +   ++   +   +LTLLL+   P +   G +
Sbjct: 815  TTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVV 874

Query: 295  MGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEA----CRCR 350
                L   + + ++++  +  +A EA+ N RTV +   EQ+ E  Y   L+        +
Sbjct: 875  EMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRK 934

Query: 351  AEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMA- 409
            A   G   +  Q +   ++     G    G  LVA + ++  D++  LV S  V  +MA 
Sbjct: 935  AHIFGITFSFTQAMMYFSY----AGCFRFGAYLVAHKLMSFEDVL--LVFSAVVFGAMAV 988

Query: 410  -NLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRP 468
              +S       +   + A +   +   P I       +    L G+VTF  V F+YP RP
Sbjct: 989  GQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRP 1048

Query: 469  GFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSW 528
               VL+  +L +  G+ +ALVG SG GK+TV  LLERFYDP AG V+LDG++++ L+  W
Sbjct: 1049 DIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQW 1108

Query: 529  LRGQVVGFISQEPVLFGTTIMENIRFGKLE--ASDEEVYTAAREANAHEFITSFPEGYNT 586
            LR  + G +SQEP+LF  +I ENI +G      S EE+  AA+EAN H FI S P  Y+T
Sbjct: 1109 LRAHL-GIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYST 1167

Query: 587  VVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTV 646
             VG++GT LSGGQKQR+AIARAL++QP +L+LDEATSALD ESE+VVQEALD+A  GRT 
Sbjct: 1168 KVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTC 1227

Query: 647  LVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIRRQA 694
            +VIAHRLST++ A  IVV  +GRV E GTH++LL + G+Y  ++  QA
Sbjct: 1228 IVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1275



 Score =  319 bits (817), Expect = 6e-87
 Identities = 212/602 (35%), Positives = 325/602 (53%), Gaps = 35/602 (5%)

Query: 119 LFWQFLHPHLLVLGVAVVLALGAALVNVQIPLLL-------------GQLVEVVAKYTR- 164
           +F  F + + L     VV  L A +    +PL++             G L ++++  T  
Sbjct: 36  VFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNR 95

Query: 165 ---DHVGSFMTESQNLSTHLLILYGV-QGLLTFGYLVLLSH--VGERMAVDMRRALFSSL 218
              +  G FM   ++++ +     G+  G+L   Y+ +        R    +R+  F ++
Sbjct: 96  SDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAI 155

Query: 219 LRQDITFFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRS-CTQVAGCLVSLSMLSTRL 277
           +RQ+I +FD +  G+L +RLT DV +        I    +S  T   G +V  +    +L
Sbjct: 156 MRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTR-GWKL 214

Query: 278 TLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREE 337
           TL+++  +P L     +    L   + +     A+A  VA+E L  +RTV AF  +++E 
Sbjct: 215 TLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKEL 274

Query: 338 ERYGAELEACR------CRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTG 391
           ERY   LE  +           +  G A     ++ A       TL + G    GQ LT 
Sbjct: 275 ERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTV 334

Query: 392 GDLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQL 451
               S L+ + +V ++  ++        RG  A   +F+ +   P I          + +
Sbjct: 335 --FFSVLIGAFSVGQASPSIEAFAN--ARG--AAYEIFKIIDNKPSIDSYSKSGHKPDNI 388

Query: 452 RGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTA 511
           +G++ F+NV FSYP R   ++LK   L +  G+ VALVG SG GK+T   L++R YDPT 
Sbjct: 389 KGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTE 448

Query: 512 GVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREA 571
           G+V +DG+D+RT++  +LR +++G +SQEPVLF TTI ENIR+G+   + +E+  A +EA
Sbjct: 449 GMVSVDGQDIRTINVRFLR-EIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEA 507

Query: 572 NAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESER 631
           NA++FI   P  ++T+VGERG  LSGGQKQR+AIARAL++ P +L+LDEATSALD ESE 
Sbjct: 508 NAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA 567

Query: 632 VVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIR 691
           VVQ ALD+A  GRT +VIAHRLSTVR A  I    DG + E G H+EL+K+ G+Y +L+ 
Sbjct: 568 VVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVT 627

Query: 692 RQ 693
            Q
Sbjct: 628 MQ 629


>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
           [Homo sapiens]
          Length = 1321

 Score =  322 bits (826), Expect = 6e-88
 Identities = 193/511 (37%), Positives = 293/511 (57%), Gaps = 10/511 (1%)

Query: 190 LLTFGYLVLLSHV--GERMAVDMRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKS 247
           +L  GY+ +   V    R    MR+  F  ++R +I +FD N  G+L +R + D+ +   
Sbjct: 152 VLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDINKIND 211

Query: 248 SFKLVISQGLRSCTQ-VAGCLVSLSMLSTRLTLLLMVATPALMGVGTL-MGSGLRKLSRQ 305
           +    ++  ++  T  + G L+       +LTL+++  +P L+G+G   +G  + K +  
Sbjct: 212 AIADQMALFIQRMTSTICGFLLGF-FRGWKLTLVIISVSP-LIGIGAATIGLSVSKFTDY 269

Query: 306 CQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLS 365
             +  A+A  VADE + ++RTV AF  E+RE ERY   L   +      G  +  F G  
Sbjct: 270 ELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFV 329

Query: 366 -NIAFNCMVLGTLFIGGSLVAGQ-QLTGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLS 423
             + F C  L   + G +LV  + + T G L+   ++      ++ N S        G +
Sbjct: 330 WCLIFLCYALA-FWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRA 388

Query: 424 AGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPG 483
           A   +FE +   P I          ++++G + F NV F YP RP  ++L D  + + PG
Sbjct: 389 AATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPG 448

Query: 484 KIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVL 543
           ++ ALVG SG GK+T   L++RFYDP  G+V +DG D+R+L+  WLR Q+ G + QEPVL
Sbjct: 449 EMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQI-GIVEQEPVL 507

Query: 544 FGTTIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRL 603
           F TTI ENIR+G+ +A+ E++  AA+EANA+ FI   P+ ++T+VGE G  +SGGQKQR+
Sbjct: 508 FSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRV 567

Query: 604 AIARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIV 663
           AIARALI+ P +L+LD ATSALD ESE +VQE L +   G T++ +AHRLSTVR A  I+
Sbjct: 568 AIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTII 627

Query: 664 VMADGRVWEAGTHEELLKKGGLYAELIRRQA 694
               G   E GTHEELL++ G+Y  L+  Q+
Sbjct: 628 GFEHGTAVERGTHEELLERKGVYFTLVTLQS 658



 Score =  287 bits (735), Expect = 2e-77
 Identities = 184/499 (36%), Positives = 272/499 (54%), Gaps = 19/499 (3%)

Query: 203  GERMAVDMRRALFSSLLRQDITFFD--ANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSC 260
            GE +   +R+  F ++L QDI +FD   N  G L +RL TD  + + +    I   + S 
Sbjct: 824  GELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSF 883

Query: 261  TQVAGCLVSLSMLSTRLTLLLMVATPALMGVG---TLMGSGLRKLSRQCQEQIARAMGVA 317
            T V   ++     S +L+L+++   P L   G   T M +G     +Q  E + +   + 
Sbjct: 884  TNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQ---IT 940

Query: 318  DEALGNVRTVRAFAMEQREEERYGAELE----ACRCRAEELGRGIALFQGLSNIAFNCMV 373
            +EAL N+RTV     E+R  E    ELE        +A   G   A  Q +  IA +   
Sbjct: 941  NEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSA-- 998

Query: 374  LGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGARVFEYMA 433
              +   GG L++ + L    +   + A      ++           +   + AR F+ + 
Sbjct: 999  --SYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLD 1056

Query: 434  LNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSG 493
              P I +        +  +G + F +  F+YP RP  +VL   ++++ PG+ +A VG SG
Sbjct: 1057 RQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSG 1116

Query: 494  GGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIR 553
             GK+T   LLERFYDP  G VM+DG D + ++  +LR  + G +SQEPVLF  +IM+NI+
Sbjct: 1117 CGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNI-GIVSQEPVLFACSIMDNIK 1175

Query: 554  FGK--LEASDEEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIK 611
            +G    E   E V  AA++A  H+F+ S PE Y T VG +G+ LS G+KQR+AIARA+++
Sbjct: 1176 YGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVR 1235

Query: 612  QPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVW 671
             P +L+LDEATSALD ESE+ VQ ALD+A  GRT +VIAHRLST++ A  I VMA G V 
Sbjct: 1236 DPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVI 1295

Query: 672  EAGTHEELLKKGGLYAELI 690
            E GTHEEL+ + G Y +L+
Sbjct: 1296 EKGTHEELMAQKGAYYKLV 1314


>gi|73747915 transporter 2, ATP-binding cassette, sub-family B
           isoform 1 [Homo sapiens]
          Length = 703

 Score =  319 bits (818), Expect = 5e-87
 Identities = 211/585 (36%), Positives = 322/585 (55%), Gaps = 19/585 (3%)

Query: 116 NWKLFWQFL---HPHLLVLGVAVVLALGAALVNVQIPLLLGQLVEVVAKYTRDHVGSFMT 172
           N  L W+ L    P L +L  A    + A L    IP   G++++++        G F  
Sbjct: 134 NKVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYSGRVIDILG-------GDFDP 186

Query: 173 ESQNLSTHLLILYGVQGLLTFGYLV-LLSHVGERMAVDMRRALFSSLLRQDITFFDANKT 231
            +   +   + L+     L+ G      ++   R+ + +R  LFSSLLRQD+ FF   KT
Sbjct: 187 HAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQETKT 246

Query: 232 GQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGV 291
           G+L SRL++D     +   L  +  LRS  +V G    +  +S RLTLL ++  P  +  
Sbjct: 247 GELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLLSLLHMPFTIAA 306

Query: 292 GTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRA 351
             +  +  +++ R+ Q+ +ARA  V  EA+G ++TVR+F  E+ E  RY   LE CR   
Sbjct: 307 EKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLY 366

Query: 352 EELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMANL 411
                  AL+  +  +    + +  L  G   +   +LT G L+SF++  ++V   +  L
Sbjct: 367 WRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESVGSYVQTL 426

Query: 412 SVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFE 471
             ++G ++  + A  +VF YM   P +P S G   P   L+G V FQ+V F+YP RP   
Sbjct: 427 VYIYGDMLSNVGAAEKVFSYMDRQPNLP-SPGTLAPTT-LQGVVKFQDVSFAYPNRPDRP 484

Query: 472 VLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRG 531
           VLK  T TL PG++ ALVG +G GK+TVA+LL+  Y PT G V+LD + +   +  +L  
Sbjct: 485 VLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHS 544

Query: 532 QVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEGYNTVVGER 591
           QVV  + QEPVLF  ++  NI +G     D++V  AA+ A+A +FI     G  T VGE+
Sbjct: 545 QVVS-VGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEK 603

Query: 592 GTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAH 651
           G+ L+ GQKQRLAIARAL++ P VLILDEATSALD + E+ +Q+   R    RTVLVIAH
Sbjct: 604 GSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDWNSRGD--RTVLVIAH 661

Query: 652 RLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIRRQALD 696
           RL  V+ AH I+V+ +G++ +     +L +   LY+ L++++ +D
Sbjct: 662 RLQAVQRAHQILVLQEGKLQKLA---QLQEGQDLYSRLVQQRLMD 703


>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
           [Homo sapiens]
          Length = 1286

 Score =  318 bits (815), Expect = 1e-86
 Identities = 193/489 (39%), Positives = 284/489 (58%), Gaps = 11/489 (2%)

Query: 210 MRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRS-CTQVAGCLV 268
           +R+  F ++LRQ+I +FD N T +L +RLT D+ +        +    ++  T  AG +V
Sbjct: 149 IRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIV 208

Query: 269 SLSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVR 328
              +   +LTL++M  +P L     +    L   S +     A+A  VA+EALG +RTV 
Sbjct: 209 GF-IRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVI 267

Query: 329 AFAMEQREEERYGAELEACRCRAEELGRGIALFQGLS-NIAFNCMVLG---TLFIGGSLV 384
           AF  + +E ERY   LE     A+E+G   A+   +S  IAF  +        + G +LV
Sbjct: 268 AFGGQNKELERYQKHLE----NAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLV 323

Query: 385 AGQQLTGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGC 444
             ++ T G+ M+   +      S+   +           A   +F+ +  NP I      
Sbjct: 324 ISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSER 383

Query: 445 CVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLE 504
               + ++G++ F +V FSYP R   ++LK   L +  G+ VALVG SG GK+T   L++
Sbjct: 384 GHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQ 443

Query: 505 RFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEV 564
           R YDP  G + +DG+D+R  + ++LR +++G +SQEPVLF TTI ENI +G+   + +E+
Sbjct: 444 RLYDPDEGTINIDGQDIRNFNVNYLR-EIIGVVSQEPVLFSTTIAENICYGRGNVTMDEI 502

Query: 565 YTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSA 624
             A +EANA+EFI   P+ ++T+VGERG  LSGGQKQR+AIARAL++ P +L+LDEATSA
Sbjct: 503 KKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSA 562

Query: 625 LDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGG 684
           LD ESE  VQ ALD+A  GRT +VIAHRLSTVR A  I    DG + E G+H EL+KK G
Sbjct: 563 LDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEG 622

Query: 685 LYAELIRRQ 693
           +Y +L+  Q
Sbjct: 623 VYFKLVNMQ 631



 Score =  303 bits (776), Expect = 4e-82
 Identities = 189/533 (35%), Positives = 291/533 (54%), Gaps = 17/533 (3%)

Query: 176  NLSTHLLILYGVQGLLTF---GYLVLLSHVGERMAVDMRRALFSSLLRQDITFFD--ANK 230
            N+ + + +  G+    TF   G+       GE +   +R   F ++LRQD+++FD   N 
Sbjct: 752  NIFSLIFLFLGIISFFTFFLQGFT--FGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNS 809

Query: 231  TGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMG 290
            TG L +RL TD  + + +    ++   ++   +   ++   +   +LTLLL+   P +  
Sbjct: 810  TGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAV 869

Query: 291  VGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCR 350
             G +    L   +++ ++++  A  +A EA+ N+RTV +   E++ E  Y  +L      
Sbjct: 870  SGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRN 929

Query: 351  AEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMAN 410
            + +      +   +S         G    G  L+    +   D++    A      ++ +
Sbjct: 930  SVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGH 989

Query: 411  LSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGF 470
             S       +   + A +F      P I       +  ++  G++TF  V F+YP R   
Sbjct: 990  ASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANV 1049

Query: 471  EVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVV-------MLDGRDLRT 523
             VL+  +L +  G+ +ALVG SG GK+TV  LLERFYDP AG V       +LDG++ + 
Sbjct: 1050 PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKK 1109

Query: 524  LDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLE--ASDEEVYTAAREANAHEFITSFP 581
            L+  WLR Q+ G +SQEP+LF  +I ENI +G      S +E+ +AA+ AN H FI + P
Sbjct: 1110 LNVQWLRAQL-GIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLP 1168

Query: 582  EGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRAS 641
              Y T VG++GT LSGGQKQR+AIARALI+QP +L+LDEATSALD ESE+VVQEALD+A 
Sbjct: 1169 HKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAR 1228

Query: 642  AGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIRRQA 694
             GRT +VIAHRLST++ A  IVV  +GRV E GTH++LL + G+Y  ++  QA
Sbjct: 1229 EGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1281


>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
           [Homo sapiens]
          Length = 1232

 Score =  318 bits (815), Expect = 1e-86
 Identities = 193/489 (39%), Positives = 284/489 (58%), Gaps = 11/489 (2%)

Query: 210 MRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRS-CTQVAGCLV 268
           +R+  F ++LRQ+I +FD N T +L +RLT D+ +        +    ++  T  AG +V
Sbjct: 149 IRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIV 208

Query: 269 SLSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVR 328
              +   +LTL++M  +P L     +    L   S +     A+A  VA+EALG +RTV 
Sbjct: 209 GF-IRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVI 267

Query: 329 AFAMEQREEERYGAELEACRCRAEELGRGIALFQGLS-NIAFNCMVLG---TLFIGGSLV 384
           AF  + +E ERY   LE     A+E+G   A+   +S  IAF  +        + G +LV
Sbjct: 268 AFGGQNKELERYQKHLE----NAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLV 323

Query: 385 AGQQLTGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGC 444
             ++ T G+ M+   +      S+   +           A   +F+ +  NP I      
Sbjct: 324 ISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSER 383

Query: 445 CVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLE 504
               + ++G++ F +V FSYP R   ++LK   L +  G+ VALVG SG GK+T   L++
Sbjct: 384 GHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQ 443

Query: 505 RFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEV 564
           R YDP  G + +DG+D+R  + ++LR +++G +SQEPVLF TTI ENI +G+   + +E+
Sbjct: 444 RLYDPDEGTINIDGQDIRNFNVNYLR-EIIGVVSQEPVLFSTTIAENICYGRGNVTMDEI 502

Query: 565 YTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSA 624
             A +EANA+EFI   P+ ++T+VGERG  LSGGQKQR+AIARAL++ P +L+LDEATSA
Sbjct: 503 KKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSA 562

Query: 625 LDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGG 684
           LD ESE  VQ ALD+A  GRT +VIAHRLSTVR A  I    DG + E G+H EL+KK G
Sbjct: 563 LDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEG 622

Query: 685 LYAELIRRQ 693
           +Y +L+  Q
Sbjct: 623 VYFKLVNMQ 631



 Score =  300 bits (769), Expect = 2e-81
 Identities = 192/526 (36%), Positives = 287/526 (54%), Gaps = 57/526 (10%)

Query: 176  NLSTHLLILYGVQGLLTF---GYLVLLSHVGERMAVDMRRALFSSLLRQDITFFD--ANK 230
            N+ + + +  G+    TF   G+       GE +   +R   F ++LRQD+++FD   N 
Sbjct: 752  NIFSLIFLFLGIISFFTFFLQGFT--FGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNS 809

Query: 231  TGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMG 290
            TG L +RL TD  + + +    ++   ++   +   ++   +   +LTLLL+   P +  
Sbjct: 810  TGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAV 869

Query: 291  VGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCR 350
             G +    L   +++ ++++  A  +A EA+ N+RTV +   E++ E  Y  +L      
Sbjct: 870  SGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKL------ 923

Query: 351  AEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMAN 410
                      ++  S I F  + LG                    SF       + S A+
Sbjct: 924  -------YGPYRVFSAIVFGAVALG-----------------HASSFAPDYAKAKLSAAH 959

Query: 411  LSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGF 470
            L +LF +                  P I       +  ++  G++TF  V F+YP R   
Sbjct: 960  LFMLFER-----------------QPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANV 1002

Query: 471  EVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLR 530
             VL+  +L +  G+ +ALVG SG GK+TV  LLERFYDP AG V+LDG++ + L+  WLR
Sbjct: 1003 PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLR 1062

Query: 531  GQVVGFISQEPVLFGTTIMENIRFGKLE--ASDEEVYTAAREANAHEFITSFPEGYNTVV 588
             Q+ G +SQEP+LF  +I ENI +G      S +E+ +AA+ AN H FI + P  Y T V
Sbjct: 1063 AQL-GIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRV 1121

Query: 589  GERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLV 648
            G++GT LSGGQKQR+AIARALI+QP +L+LDEATSALD ESE+VVQEALD+A  GRT +V
Sbjct: 1122 GDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIV 1181

Query: 649  IAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIRRQA 694
            IAHRLST++ A  IVV  +GRV E GTH++LL + G+Y  ++  QA
Sbjct: 1182 IAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1227


>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
           [Homo sapiens]
          Length = 1279

 Score =  318 bits (815), Expect = 1e-86
 Identities = 193/489 (39%), Positives = 284/489 (58%), Gaps = 11/489 (2%)

Query: 210 MRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRS-CTQVAGCLV 268
           +R+  F ++LRQ+I +FD N T +L +RLT D+ +        +    ++  T  AG +V
Sbjct: 149 IRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIV 208

Query: 269 SLSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVR 328
              +   +LTL++M  +P L     +    L   S +     A+A  VA+EALG +RTV 
Sbjct: 209 GF-IRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVI 267

Query: 329 AFAMEQREEERYGAELEACRCRAEELGRGIALFQGLS-NIAFNCMVLG---TLFIGGSLV 384
           AF  + +E ERY   LE     A+E+G   A+   +S  IAF  +        + G +LV
Sbjct: 268 AFGGQNKELERYQKHLE----NAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLV 323

Query: 385 AGQQLTGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGC 444
             ++ T G+ M+   +      S+   +           A   +F+ +  NP I      
Sbjct: 324 ISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSER 383

Query: 445 CVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLE 504
               + ++G++ F +V FSYP R   ++LK   L +  G+ VALVG SG GK+T   L++
Sbjct: 384 GHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQ 443

Query: 505 RFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEV 564
           R YDP  G + +DG+D+R  + ++LR +++G +SQEPVLF TTI ENI +G+   + +E+
Sbjct: 444 RLYDPDEGTINIDGQDIRNFNVNYLR-EIIGVVSQEPVLFSTTIAENICYGRGNVTMDEI 502

Query: 565 YTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSA 624
             A +EANA+EFI   P+ ++T+VGERG  LSGGQKQR+AIARAL++ P +L+LDEATSA
Sbjct: 503 KKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSA 562

Query: 625 LDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGG 684
           LD ESE  VQ ALD+A  GRT +VIAHRLSTVR A  I    DG + E G+H EL+KK G
Sbjct: 563 LDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEG 622

Query: 685 LYAELIRRQ 693
           +Y +L+  Q
Sbjct: 623 VYFKLVNMQ 631



 Score =  310 bits (794), Expect = 3e-84
 Identities = 189/526 (35%), Positives = 291/526 (55%), Gaps = 10/526 (1%)

Query: 176  NLSTHLLILYGVQGLLTF---GYLVLLSHVGERMAVDMRRALFSSLLRQDITFFD--ANK 230
            N+ + + +  G+    TF   G+       GE +   +R   F ++LRQD+++FD   N 
Sbjct: 752  NIFSLIFLFLGIISFFTFFLQGFT--FGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNS 809

Query: 231  TGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMG 290
            TG L +RL TD  + + +    ++   ++   +   ++   +   +LTLLL+   P +  
Sbjct: 810  TGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAV 869

Query: 291  VGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCR 350
             G +    L   +++ ++++  A  +A EA+ N+RTV +   E++ E  Y  +L      
Sbjct: 870  SGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRN 929

Query: 351  AEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMAN 410
            + +      +   +S         G    G  L+    +   D++    A      ++ +
Sbjct: 930  SVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGH 989

Query: 411  LSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGF 470
             S       +   + A +F      P I       +  ++  G++TF  V F+YP R   
Sbjct: 990  ASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANV 1049

Query: 471  EVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLR 530
             VL+  +L +  G+ +ALVG SG GK+TV  LLERFYDP AG V+LDG++ + L+  WLR
Sbjct: 1050 PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLR 1109

Query: 531  GQVVGFISQEPVLFGTTIMENIRFGKLE--ASDEEVYTAAREANAHEFITSFPEGYNTVV 588
             Q+ G +SQEP+LF  +I ENI +G      S +E+ +AA+ AN H FI + P  Y T V
Sbjct: 1110 AQL-GIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRV 1168

Query: 589  GERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLV 648
            G++GT LSGGQKQR+AIARALI+QP +L+LDEATSALD ESE+VVQEALD+A  GRT +V
Sbjct: 1169 GDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIV 1228

Query: 649  IAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIRRQA 694
            IAHRLST++ A  IVV  +GRV E GTH++LL + G+Y  ++  QA
Sbjct: 1229 IAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1274


>gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Homo
           sapiens]
          Length = 808

 Score =  301 bits (772), Expect = 1e-81
 Identities = 195/572 (34%), Positives = 326/572 (56%), Gaps = 15/572 (2%)

Query: 131 LGVAVVLALGAALVNVQIPLLLGQLVEVVAKYTRDHVGSFMTESQNLSTHLLILYGVQGL 190
           L + +VL + ++L  + IP   G+L + + +      GS  T ++NL T + IL     +
Sbjct: 247 LSLFLVLVVLSSLGEMAIPFFTGRLTDWILQD-----GSADTFTRNL-TLMSILTIASAV 300

Query: 191 LTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSFK 250
           L F    + ++    +   ++  +F ++LRQ+  FF  N+TG ++SR+T D      S  
Sbjct: 301 LEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLS 360

Query: 251 LVISQGLRSCTQVAGCLVSLSML-STRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQ 309
             +S  L    +   CL+ + +  S  LT++ ++  P L  +   +G   + L  Q +E 
Sbjct: 361 ENLSLFLWYLVRGL-CLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRES 419

Query: 310 IARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAF 369
           +A++  VA EAL  + TVR+FA E+ E +++  +L+  +   ++     A+    ++I+ 
Sbjct: 420 LAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISG 479

Query: 370 NCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGARVF 429
             + +G L+IGG LV    ++ G+L++F++      +++  L  ++ +V + + +  ++F
Sbjct: 480 MLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIF 539

Query: 430 EYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALV 489
           EY+   P  P SG   +    L G V FQ+V F+YP RP   VL+  T TL PG++ ALV
Sbjct: 540 EYLDRTPRCPPSG--LLTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALV 597

Query: 490 GQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIM 549
           G +G GK+TVA+LL+  Y PT G ++LDG+ L   +  +L  QV   + QEP +FG ++ 
Sbjct: 598 GPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAA-VGQEPQVFGRSLQ 656

Query: 550 ENIRFGKLEASD-EEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARA 608
           ENI +G  +    EE+  AA ++ AH FI+  P+GY+T V E G+ LSGGQ+Q +A+ARA
Sbjct: 657 ENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARA 716

Query: 609 LIKQPTVLILDEATSALDAESERVVQEALDRASA--GRTVLVIAHRLSTVRGAHCIVVMA 666
           LI++P VLILD+ATSALDA S+  V++ L  +     R+VL+I   LS V  A  I+ + 
Sbjct: 717 LIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLE 776

Query: 667 DGRVWEAGTHEELLKKGGLYAELIRRQALDAP 698
            G + E GTH++L++K G Y  +++  A DAP
Sbjct: 777 GGAIREGGTHQQLMEKKGCYWAMVQAPA-DAP 807


>gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
           sapiens]
          Length = 812

 Score =  290 bits (741), Expect = 4e-78
 Identities = 182/566 (32%), Positives = 292/566 (51%), Gaps = 6/566 (1%)

Query: 135 VVLALGAALVNVQI-PLLLGQLVEVVAKYTRDHVGSFMTESQNLSTHLLILYGVQGLLTF 193
           VVL   A+++N  + P+      +++  +  +   +   +++  S   +IL  +  +  F
Sbjct: 247 VVLGTLASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDAEIYSMIFVILGVICFVSYF 306

Query: 194 GYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDA--NKTGQLVSRLTTDVQEFKSSFKL 251
              +     GE + + +R   F ++L QDI +FD   N TG L + L  D+ + + +   
Sbjct: 307 MQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLTTILAIDIAQIQGATGS 366

Query: 252 VISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIA 311
            I    ++ T +   ++   +    +T L++   P L   G +  + +   + + ++++ 
Sbjct: 367 RIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIETAAMTGFANKDKQELK 426

Query: 312 RAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNC 371
            A  +A EAL N+RT+ +   E+  E+ Y   L+       +  + I      S+     
Sbjct: 427 HAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSKKAQIIGSCYAFSHAFIYF 486

Query: 372 MVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGARVFEY 431
                   G  L+   ++T   +     A      ++    VL  +  +  S  A +F  
Sbjct: 487 AYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGETLVLAPEYSKAKSGAAHLFAL 546

Query: 432 MALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQ 491
           +   P I          +   G++ F+ V F YPCRP   +L+  +L++  GK VA VG 
Sbjct: 547 LEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGS 606

Query: 492 SGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMEN 551
           SG GK+T   LL+R YDP  G V+ DG D + L+  WLR Q+   + QEPVLF  +I EN
Sbjct: 607 SGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQIA-IVPQEPVLFNCSIAEN 665

Query: 552 IRFGKLE--ASDEEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARAL 609
           I +G        +E+  AA  AN H FI   PE YNT VG +G  LSGGQKQRLAIARAL
Sbjct: 666 IAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARAL 725

Query: 610 IKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGR 669
           +++P +L+LDEATSALD +SE+VVQ ALD+A  GRT LV+ HRLS ++ A  IVV+ +G+
Sbjct: 726 LQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGK 785

Query: 670 VWEAGTHEELLKKGGLYAELIRRQAL 695
           + E GTH+ELL+   +Y +L+  Q++
Sbjct: 786 IKEQGTHQELLRNRDIYFKLVNAQSV 811



 Score =  201 bits (512), Expect = 1e-51
 Identities = 101/179 (56%), Positives = 133/179 (74%), Gaps = 1/179 (0%)

Query: 515 MLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREANAH 574
           M+D  D+R L+    R  + G +SQEPVLFGTTI  NI++G+ + +DEE+  AAREANA+
Sbjct: 1   MVDENDIRALNVRHYRDHI-GVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAY 59

Query: 575 EFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQ 634
           +FI  FP  +NT+VGE+G  +SGGQKQR+AIARAL++ P +LILDEATSALD+ES+  VQ
Sbjct: 60  DFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQ 119

Query: 635 EALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIRRQ 693
            AL++AS GRT +V+AHRLST+R A  IV + DG + E G H EL+ K GLY  L+  Q
Sbjct: 120 AALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQ 178


>gi|73747917 transporter 2, ATP-binding cassette, sub-family B
           isoform 2 [Homo sapiens]
          Length = 653

 Score =  286 bits (731), Expect = 6e-77
 Identities = 188/520 (36%), Positives = 282/520 (54%), Gaps = 14/520 (2%)

Query: 116 NWKLFWQFL---HPHLLVLGVAVVLALGAALVNVQIPLLLGQLVEVVAKYTRDHVGSFMT 172
           N  L W+ L    P L +L  A    + A L    IP   G++++++        G F  
Sbjct: 134 NKVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYSGRVIDILG-------GDFDP 186

Query: 173 ESQNLSTHLLILYGVQGLLTFGYLV-LLSHVGERMAVDMRRALFSSLLRQDITFFDANKT 231
            +   +   + L+     L+ G      ++   R+ + +R  LFSSLLRQD+ FF   KT
Sbjct: 187 HAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQETKT 246

Query: 232 GQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGV 291
           G+L SRL++D     +   L  +  LRS  +V G    +  +S RLTLL ++  P  +  
Sbjct: 247 GELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLLSLLHMPFTIAA 306

Query: 292 GTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRA 351
             +  +  +++ R+ Q+ +ARA  V  EA+G ++TVR+F  E+ E  RY   LE CR   
Sbjct: 307 EKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLY 366

Query: 352 EELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMANL 411
                  AL+  +  +    + +  L  G   +   +LT G L+SF++  ++V   +  L
Sbjct: 367 WRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESVGSYVQTL 426

Query: 412 SVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFE 471
             ++G ++  + A  +VF YM   P +P S G   P   L+G V FQ+V F+YP RP   
Sbjct: 427 VYIYGDMLSNVGAAEKVFSYMDRQPNLP-SPGTLAPTT-LQGVVKFQDVSFAYPNRPDRP 484

Query: 472 VLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRG 531
           VLK  T TL PG++ ALVG +G GK+TVA+LL+  Y PT G V+LD + +   +  +L  
Sbjct: 485 VLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHS 544

Query: 532 QVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEGYNTVVGER 591
           QVV  + QEPVLF  ++  NI +G     D++V  AA+ A+A +FI     G  T VGE+
Sbjct: 545 QVVS-VGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEK 603

Query: 592 GTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESER 631
           G+ L+ GQKQRLAIARAL++ P VLILDEATSALD + E+
Sbjct: 604 GSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQ 643


>gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo
           sapiens]
          Length = 842

 Score =  238 bits (608), Expect = 1e-62
 Identities = 144/387 (37%), Positives = 216/387 (55%), Gaps = 6/387 (1%)

Query: 307 QEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSN 366
           QE   RA  V  ++L N  TV+ +  E  E ERY   +   +    +    + L     N
Sbjct: 445 QENATRARAV--DSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSASLVLLNQTQN 502

Query: 367 IAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGA 426
           +     +L    +    V  Q+L  GD + F      +   +      +  +        
Sbjct: 503 LVIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYRMIQTNFIDME 562

Query: 427 RVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIV 486
            +F+ +     +    G   P    +G + F+NV FSY    G E L+D + T+ PG+ +
Sbjct: 563 NMFDLLKEETEVKDLPGAG-PLRFQKGRIEFENVHFSYA--DGRETLQDVSFTVMPGQTL 619

Query: 487 ALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGT 546
           ALVG SG GK+T+  LL RFYD ++G + +DG+D+  +  + LR  + G + Q+ VLF  
Sbjct: 620 ALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHI-GVVPQDTVLFND 678

Query: 547 TIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIA 606
           TI +NIR+G++ A ++EV  AA+ A  H+ I +FPEGY T VGERG  LSGG+KQR+AIA
Sbjct: 679 TIADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIA 738

Query: 607 RALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMA 666
           R ++K P +++LDEATSALD  +ER +Q +L +  A RT +V+AHRLSTV  A  I+V+ 
Sbjct: 739 RTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIK 798

Query: 667 DGRVWEAGTHEELLKKGGLYAELIRRQ 693
           DG + E G HE LL +GG+YA++ + Q
Sbjct: 799 DGCIVERGRHEALLSRGGVYADMWQLQ 825


>gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo
           sapiens]
          Length = 753

 Score =  199 bits (505), Expect = 1e-50
 Identities = 164/571 (28%), Positives = 277/571 (48%), Gaps = 26/571 (4%)

Query: 140 GAALVNVQIPLLLGQLVEVVAKYTRDHVGSFMTESQN----LSTHLLILYGVQ--GLLTF 193
           GA  +N+ +P +    V+ + + + + +   ++++ N    ++T +LI YGV   G   F
Sbjct: 150 GAKAMNIVVPFMFKYAVDSLNQMSGNMLN--LSDAPNTVATMATAVLIGYGVSRAGAAFF 207

Query: 194 GYL--VLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSFKL 251
             +   +   V +     + + +F  L   D+ F  + +TG L   +    +        
Sbjct: 208 NEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGFHLSRQTGALSKAIDRGTRGISFVLSA 267

Query: 252 VISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIA 311
           ++   L    +V   LVS  +L  +      + T   +G  T     + +   + + ++ 
Sbjct: 268 LVFNLLPIMFEVM--LVS-GVLYYKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMN 324

Query: 312 RAMGVADEA----LGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNI 367
           +A   A  A    L N  TV+ F  E+ E +RY   L+     + +    +A+     + 
Sbjct: 325 KADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGFLKTYETASLKSTSTLAMLNFGQSA 384

Query: 368 AFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGAR 427
            F+  +   + +    +    LT GDL+        +   +  L  ++ +  + L     
Sbjct: 385 IFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNT 444

Query: 428 VFEYMALNPCIP---LSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGK 484
           +F  + ++  I    ++    +  +    +V F NV F Y    G +VL   +  +P GK
Sbjct: 445 LFTLLKVDTQIKDKVMASPLQITPQT--ATVAFDNVHFEYI--EGQKVLSGISFEVPAGK 500

Query: 485 IVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLF 544
            VA+VG SG GK+T+  LL RFY+P  G + L G++++ +    LR + VG + Q+ VLF
Sbjct: 501 KVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLR-RAVGVVPQDAVLF 559

Query: 545 GTTIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLA 604
             TI  N+ +G + AS EEVY  A+ A  H+ I   P GY+T VGERG  LSGG+KQR+A
Sbjct: 560 HNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVA 619

Query: 605 IARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVV 664
           IARA++K P V++ DEATS+LD+ +E  +  A+      RT + IAHRLSTV  A  I+V
Sbjct: 620 IARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIV 679

Query: 665 MADGRVWEAGTHEELL-KKGGLYAELIRRQA 694
           +  G+V E GTH  LL     +Y+E+   Q+
Sbjct: 680 LDQGKVAERGTHHGLLANPHSIYSEMWHTQS 710


>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
            sapiens]
          Length = 1464

 Score =  164 bits (415), Expect = 3e-40
 Identities = 155/540 (28%), Positives = 260/540 (48%), Gaps = 44/540 (8%)

Query: 186  GVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEF 245
            GV  L T    VL +    + A  + R L   +L   +TFF+A  TG++++R ++DV   
Sbjct: 948  GVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSDVACA 1007

Query: 246  KSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALM---GVGTLMGSGLRKL 302
              S   +++  L +    AG L  L++L + L  LL++  P  +    V     +  R+L
Sbjct: 1008 DDSLPFILNILLANA---AGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHYRASSREL 1064

Query: 303  SRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEAC-RC------------ 349
             R     ++       + L  +  +RA     R EE     LE   RC            
Sbjct: 1065 RRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRCQFATSATMQWLD 1124

Query: 350  -RAEELGRGI-ALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRS 407
             R + +G  + +   G++ +     +     +G SL     LTG  L+S LV+S T   +
Sbjct: 1125 IRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTG--LLSGLVSSFTQTEA 1182

Query: 408  MANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQL-RGSVTFQNVCFSYPC 466
            M             L +  R+ EY    P  P      +    L +G V FQ+V  +Y  
Sbjct: 1183 M-------------LVSVERLEEYTCDLPQEPQGQPLQLGTGWLTQGGVEFQDVVLAY-- 1227

Query: 467  RPGF-EVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLD 525
            RPG    L   T  + PG+ + +VG++G GK+++  +L R  +P++G V+LDG D   L+
Sbjct: 1228 RPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLE 1287

Query: 526  PSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEGYN 585
             + LR Q+   I QEP LF  T+ EN+    L   D  ++ A ++ +  E ITS   G +
Sbjct: 1288 LAQLRSQLA-IIPQEPFLFSGTVRENLDPQGLH-KDRALWQALKQCHLSEVITSMG-GLD 1344

Query: 586  TVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRT 645
              +GE G +LS GQ+Q L +ARAL+    +L +DEAT+++D ++++++Q+ + +  A +T
Sbjct: 1345 GELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKT 1404

Query: 646  VLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKK-GGLYAELIRRQALDAPRTAAPP 704
            VL IAHRL+T+  +  ++V+  GRV E  +   L  +   L+ +L++      P +   P
Sbjct: 1405 VLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQSSQQGVPASLGGP 1464



 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 147/602 (24%), Positives = 248/602 (41%), Gaps = 86/602 (14%)

Query: 117 WKLFWQFLHPHLLVLGVAVVLALGAALVNVQIPLLLGQLVEVVAKYTRDHVGSFMTESQN 176
           W+  +       L LG+   L L   ++    PLLL  LV             F+ E Q 
Sbjct: 231 WRALYGAFGRCYLALGL---LKLVGTMLGFSGPLLLSLLV------------GFLEEGQE 275

Query: 177 LSTH-LLILYGVQGLLTFGYLVLLSHVGE--RMAVDMRRALFSSLLRQDITFFDANK-TG 232
             +H LL   G+ G    G ++   +  E  ++ +  R A+ + L  + +    +   TG
Sbjct: 276 PLSHGLLYALGLAGGAVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKALQLGPSRPPTG 335

Query: 233 QLVSRLTTDVQE---FKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALM 289
           + ++ L TD +    F  SF       L+    +      + +      +L ++  P   
Sbjct: 336 EALNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNK 395

Query: 290 GVGT-LMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACR 348
            + T +M S    L    Q + AR   V  E L  +R ++    EQ      GA +EACR
Sbjct: 396 VIATRIMASNQEML----QHKDARVKLVT-ELLSGIRVIKFCGWEQA----LGARVEACR 446

Query: 349 CRAEELGRGIALFQGLSNIAFNCM--------VLGTLFIGGSLVAGQQLTGGDLMSFLVA 400
            R  ELGR     + +  +   C+        V+  +     ++ G QLT   + + L  
Sbjct: 447 AR--ELGR----LRVIKYLDAACVYLWAALPVVISIVIFITYVLMGHQLTATKVFTALAL 500

Query: 401 SQTVQRSMANLSVLFGQVVRGLSAGARVFEYMAL---NP-------CIPLSGG-----CC 445
            + +   + N   +   ++    +  R+  ++ L   NP       C  L        C 
Sbjct: 501 VRMLILPLNNFPWVINGLLEAKVSLDRIQLFLDLPNHNPQAYYSPDCGRLGAQIKWLLCS 560

Query: 446 VPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFT--LTLPPGKIVALVGQSGGGKTTVASLL 503
            P  +    +      FS+   P    L+ F   L +  G +V +VG+ G GK+++ + +
Sbjct: 561 DPPAEPSTVLELHGALFSWD--PVGTSLETFISHLEVKKGMLVGIVGKVGCGKSSLLAAI 618

Query: 504 ERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEE 563
                   G V + G             +  G  +QEP +   TI +NI FGK    D +
Sbjct: 619 AGELHRLRGHVAVRGLS-----------KGFGLATQEPWIQFATIRDNILFGK--TFDAQ 665

Query: 564 VYTAAREANA-HEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEAT 622
           +Y    EA A ++ ++  P G  T VGE+G TLSGGQ+ R+A+ARA+ ++  + +LD+  
Sbjct: 666 LYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKELYLLDDPL 725

Query: 623 SALDAESERVVQEALDRASAG----RTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEE 678
           +A+DA+   V    L R   G     T L+  HR   +  A  +++M  GR+  AG   E
Sbjct: 726 AAVDAD---VANHLLHRCILGMLSYTTRLLCTHRTEYLERADAVLLMEAGRLIRAGPPSE 782

Query: 679 LL 680
           +L
Sbjct: 783 IL 784


>gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3
            [Homo sapiens]
          Length = 1475

 Score =  155 bits (393), Expect = 9e-38
 Identities = 138/532 (25%), Positives = 246/532 (46%), Gaps = 35/532 (6%)

Query: 182  LILYGV----QGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSR 237
            L +YG     QG+  FGY + +S  G   +  +   L  S+LR  ++FF+   +G LV+R
Sbjct: 960  LSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNR 1019

Query: 238  LTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGS 297
             + ++    S    VI   + S   V G  + + + +    +++         V     +
Sbjct: 1020 FSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVA 1079

Query: 298  GLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQR-----------EEERYGAELEA 346
              R+L R      +      +E L  V  +RAF  ++R            ++ Y   + A
Sbjct: 1080 SSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVA 1139

Query: 347  CRCRAEELGRGIALFQGLSNIAFNCMVL-GTLFIGGSLVAGQQLTGGDLMSFLVASQTVQ 405
             R  A  L               NC+VL   LF   ++++   L+ G +   +  S  V 
Sbjct: 1140 NRWLAVRL-----------ECVGNCIVLFAALF---AVISRHSLSAGLVGLSVSYSLQVT 1185

Query: 406  RSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQLR--GSVTFQNVCFS 463
              +  L  +  ++   + A  R+ EY       P       P       G V F+N C  
Sbjct: 1186 TYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLR 1245

Query: 464  YPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRT 523
            Y     F VL+   +T+  G+ V +VG++G GK+++   L R  +   G +++DG ++  
Sbjct: 1246 YREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAK 1304

Query: 524  LDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEG 583
            +    LR ++   I Q+PVLF  ++  N+     + SDEEV+T+   A+  +F+++ P+ 
Sbjct: 1305 IGLHDLRFKIT-IIPQDPVLFSGSLRMNLDPFS-QYSDEEVWTSLELAHLKDFVSALPDK 1362

Query: 584  YNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAG 643
             +    E G  LS GQ+Q + +ARAL+++  +L+LDEAT+A+D E++ ++Q  +      
Sbjct: 1363 LDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFED 1422

Query: 644  RTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIRRQAL 695
             TVL IAHRL+T+     ++V+  G + E G   +LL++ GL+  + +   L
Sbjct: 1423 CTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGL 1474



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 58/243 (23%), Positives = 97/243 (39%), Gaps = 73/243 (30%)

Query: 454 SVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGV 513
           S+T +N  F++  R     L   T ++P G +VA+VGQ G GK+++ S L    D   G 
Sbjct: 643 SITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGH 701

Query: 514 VMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFG-KLEASDEEVYTAAREAN 572
           V + G               V ++ Q+  +   ++ ENI FG +LE   E  Y +  +A 
Sbjct: 702 VAIKGS--------------VAYVPQQAWIQNDSLRENILFGCQLE---EPYYRSVIQAC 744

Query: 573 A-HEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESER 631
           A    +   P G  T +GE+                                        
Sbjct: 745 ALLPDLEILPSGDRTEIGEK---------------------------------------- 764

Query: 632 VVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIR 691
                        T +++ H +S +     I+VM+ G++ E G+++ELL + G +AE +R
Sbjct: 765 -------------TRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLR 811

Query: 692 RQA 694
             A
Sbjct: 812 TYA 814


>gi|134142342 ATP-binding cassette, sub-family C, member 1 isoform 4
            [Homo sapiens]
          Length = 1416

 Score =  155 bits (393), Expect = 9e-38
 Identities = 138/532 (25%), Positives = 246/532 (46%), Gaps = 35/532 (6%)

Query: 182  LILYGV----QGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSR 237
            L +YG     QG+  FGY + +S  G   +  +   L  S+LR  ++FF+   +G LV+R
Sbjct: 901  LSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNR 960

Query: 238  LTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGS 297
             + ++    S    VI   + S   V G  + + + +    +++         V     +
Sbjct: 961  FSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVA 1020

Query: 298  GLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQR-----------EEERYGAELEA 346
              R+L R      +      +E L  V  +RAF  ++R            ++ Y   + A
Sbjct: 1021 SSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVA 1080

Query: 347  CRCRAEELGRGIALFQGLSNIAFNCMVL-GTLFIGGSLVAGQQLTGGDLMSFLVASQTVQ 405
             R  A  L               NC+VL   LF   ++++   L+ G +   +  S  V 
Sbjct: 1081 NRWLAVRL-----------ECVGNCIVLFAALF---AVISRHSLSAGLVGLSVSYSLQVT 1126

Query: 406  RSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQLR--GSVTFQNVCFS 463
              +  L  +  ++   + A  R+ EY       P       P       G V F+N C  
Sbjct: 1127 TYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLR 1186

Query: 464  YPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRT 523
            Y     F VL+   +T+  G+ V +VG++G GK+++   L R  +   G +++DG ++  
Sbjct: 1187 YREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAK 1245

Query: 524  LDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEG 583
            +    LR ++   I Q+PVLF  ++  N+     + SDEEV+T+   A+  +F+++ P+ 
Sbjct: 1246 IGLHDLRFKIT-IIPQDPVLFSGSLRMNLDPFS-QYSDEEVWTSLELAHLKDFVSALPDK 1303

Query: 584  YNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAG 643
             +    E G  LS GQ+Q + +ARAL+++  +L+LDEAT+A+D E++ ++Q  +      
Sbjct: 1304 LDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFED 1363

Query: 644  RTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIRRQAL 695
             TVL IAHRL+T+     ++V+  G + E G   +LL++ GL+  + +   L
Sbjct: 1364 CTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGL 1415



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 24/72 (33%), Positives = 42/72 (58%), Gaps = 5/72 (6%)

Query: 623 SALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKK 682
           SAL AE ++V         A +T +++ H +S +     I+VM+ G++ E G+++ELL +
Sbjct: 689 SALLAEMDKVEGHV-----AIKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLAR 743

Query: 683 GGLYAELIRRQA 694
            G +AE +R  A
Sbjct: 744 DGAFAEFLRTYA 755



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 27/76 (35%), Positives = 40/76 (52%), Gaps = 1/76 (1%)

Query: 454 SVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGV 513
           S+T +N  F++  R     L   T ++P G +VA+VGQ G GK+++ S L    D   G 
Sbjct: 643 SITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGH 701

Query: 514 VMLDGRDLRTLDPSWL 529
           V +  R L T   S+L
Sbjct: 702 VAIKTRILVTHSMSYL 717


>gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2
            [Homo sapiens]
          Length = 1472

 Score =  155 bits (393), Expect = 9e-38
 Identities = 138/532 (25%), Positives = 246/532 (46%), Gaps = 35/532 (6%)

Query: 182  LILYGV----QGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSR 237
            L +YG     QG+  FGY + +S  G   +  +   L  S+LR  ++FF+   +G LV+R
Sbjct: 957  LSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNR 1016

Query: 238  LTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGS 297
             + ++    S    VI   + S   V G  + + + +    +++         V     +
Sbjct: 1017 FSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVA 1076

Query: 298  GLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQR-----------EEERYGAELEA 346
              R+L R      +      +E L  V  +RAF  ++R            ++ Y   + A
Sbjct: 1077 SSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVA 1136

Query: 347  CRCRAEELGRGIALFQGLSNIAFNCMVL-GTLFIGGSLVAGQQLTGGDLMSFLVASQTVQ 405
             R  A  L               NC+VL   LF   ++++   L+ G +   +  S  V 
Sbjct: 1137 NRWLAVRL-----------ECVGNCIVLFAALF---AVISRHSLSAGLVGLSVSYSLQVT 1182

Query: 406  RSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQLR--GSVTFQNVCFS 463
              +  L  +  ++   + A  R+ EY       P       P       G V F+N C  
Sbjct: 1183 TYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLR 1242

Query: 464  YPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRT 523
            Y     F VL+   +T+  G+ V +VG++G GK+++   L R  +   G +++DG ++  
Sbjct: 1243 YREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAK 1301

Query: 524  LDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEG 583
            +    LR ++   I Q+PVLF  ++  N+     + SDEEV+T+   A+  +F+++ P+ 
Sbjct: 1302 IGLHDLRFKIT-IIPQDPVLFSGSLRMNLDPFS-QYSDEEVWTSLELAHLKDFVSALPDK 1359

Query: 584  YNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAG 643
             +    E G  LS GQ+Q + +ARAL+++  +L+LDEAT+A+D E++ ++Q  +      
Sbjct: 1360 LDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFED 1419

Query: 644  RTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIRRQAL 695
             TVL IAHRL+T+     ++V+  G + E G   +LL++ GL+  + +   L
Sbjct: 1420 CTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGL 1471



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 36/110 (32%), Positives = 64/110 (58%), Gaps = 3/110 (2%)

Query: 588 VGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASA---GR 644
           V  +G  LSGGQKQR+++ARA+     + + D+  SA+DA   + + E +         +
Sbjct: 702 VAIKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNK 761

Query: 645 TVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIRRQA 694
           T +++ H +S +     I+VM+ G++ E G+++ELL + G +AE +R  A
Sbjct: 762 TRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYA 811



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 24/68 (35%), Positives = 37/68 (54%), Gaps = 1/68 (1%)

Query: 454 SVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGV 513
           S+T +N  F++  R     L   T ++P G +VA+VGQ G GK+++ S L    D   G 
Sbjct: 643 SITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGH 701

Query: 514 VMLDGRDL 521
           V + G +L
Sbjct: 702 VAIKGVNL 709


>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
            [Homo sapiens]
          Length = 1531

 Score =  155 bits (393), Expect = 9e-38
 Identities = 138/532 (25%), Positives = 246/532 (46%), Gaps = 35/532 (6%)

Query: 182  LILYGV----QGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSR 237
            L +YG     QG+  FGY + +S  G   +  +   L  S+LR  ++FF+   +G LV+R
Sbjct: 1016 LSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNR 1075

Query: 238  LTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGS 297
             + ++    S    VI   + S   V G  + + + +    +++         V     +
Sbjct: 1076 FSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVA 1135

Query: 298  GLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQR-----------EEERYGAELEA 346
              R+L R      +      +E L  V  +RAF  ++R            ++ Y   + A
Sbjct: 1136 SSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVA 1195

Query: 347  CRCRAEELGRGIALFQGLSNIAFNCMVL-GTLFIGGSLVAGQQLTGGDLMSFLVASQTVQ 405
             R  A  L               NC+VL   LF   ++++   L+ G +   +  S  V 
Sbjct: 1196 NRWLAVRL-----------ECVGNCIVLFAALF---AVISRHSLSAGLVGLSVSYSLQVT 1241

Query: 406  RSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQLR--GSVTFQNVCFS 463
              +  L  +  ++   + A  R+ EY       P       P       G V F+N C  
Sbjct: 1242 TYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLR 1301

Query: 464  YPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRT 523
            Y     F VL+   +T+  G+ V +VG++G GK+++   L R  +   G +++DG ++  
Sbjct: 1302 YREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAK 1360

Query: 524  LDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEG 583
            +    LR ++   I Q+PVLF  ++  N+     + SDEEV+T+   A+  +F+++ P+ 
Sbjct: 1361 IGLHDLRFKIT-IIPQDPVLFSGSLRMNLDPFS-QYSDEEVWTSLELAHLKDFVSALPDK 1418

Query: 584  YNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAG 643
             +    E G  LS GQ+Q + +ARAL+++  +L+LDEAT+A+D E++ ++Q  +      
Sbjct: 1419 LDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFED 1478

Query: 644  RTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIRRQAL 695
             TVL IAHRL+T+     ++V+  G + E G   +LL++ GL+  + +   L
Sbjct: 1479 CTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGL 1530



 Score =  108 bits (271), Expect = 1e-23
 Identities = 76/246 (30%), Positives = 127/246 (51%), Gaps = 23/246 (9%)

Query: 454 SVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGV 513
           S+T +N  F++  R     L   T ++P G +VA+VGQ G GK+++ S L    D   G 
Sbjct: 643 SITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGH 701

Query: 514 VMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFG-KLEASDEEVYTAAREAN 572
           V + G               V ++ Q+  +   ++ ENI FG +LE   E  Y +  +A 
Sbjct: 702 VAIKGS--------------VAYVPQQAWIQNDSLRENILFGCQLE---EPYYRSVIQAC 744

Query: 573 AH-EFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESER 631
           A    +   P G  T +GE+G  LSGGQKQR+++ARA+     + + D+  SA+DA   +
Sbjct: 745 ALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGK 804

Query: 632 VVQEALDRASA---GRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAE 688
            + E +         +T +++ H +S +     I+VM+ G++ E G+++ELL + G +AE
Sbjct: 805 HIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAE 864

Query: 689 LIRRQA 694
            +R  A
Sbjct: 865 FLRTYA 870


>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
            [Homo sapiens]
          Length = 1545

 Score =  154 bits (389), Expect = 3e-37
 Identities = 127/528 (24%), Positives = 251/528 (47%), Gaps = 30/528 (5%)

Query: 184  LYGVQGLLTFGYLVLLSHVGERMAVD-----MRRALFSSLLRQDITFFDANKTGQLVSRL 238
            +YG  GL   G  V ++H             + + L +++LR  + FFD   TG++V+R 
Sbjct: 1026 VYGALGLAQ-GIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRF 1084

Query: 239  TTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGSG 298
              D+     +    +   +     +   LV + M +   T++++      + V     S 
Sbjct: 1085 AGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVST 1144

Query: 299  LRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGI 358
             R+L R      +       E +  +  +RAF  +QR  +     ++  +          
Sbjct: 1145 SRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQK--------- 1195

Query: 359  ALFQGLSN---IAFNCMVLGTLFIGGS---LVAGQQLTGGDLMSFLVASQ-TVQRSMANL 411
             +F  +++   +A    ++G L +  S   +V  +    GD + F++++   + +++  L
Sbjct: 1196 CVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWL 1255

Query: 412  SVLFGQVVRGLSAGARVFEYMALNPCIP-LSGGCCVPKEQLRGSVTFQNVCFSYPCRPGF 470
              +  ++   + A  R+ EY  +    P ++     P    +G + F N    Y  RP  
Sbjct: 1256 VRMTSEIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQFNNYQVRY--RPEL 1313

Query: 471  E-VLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWL 529
            + VL+  T  +   + + +VG++G GK+++ + L R  +   G +++DG D+ ++    L
Sbjct: 1314 DLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDL 1373

Query: 530  RGQVVGFISQEPVLFGTTIMENIR-FGKLEASDEEVYTAAREANAHEFITSFPEGYNTVV 588
            R ++   I Q+P+LF  ++  N+  F     SDEE++ A   A+   F+ S   G +  V
Sbjct: 1374 REKLT-IIPQDPILFSGSLRMNLDPFNNY--SDEEIWKALELAHLKSFVASLQLGLSHEV 1430

Query: 589  GERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLV 648
             E G  LS GQ+Q L + RAL+++  +L+LDEAT+A+D E++ ++Q  +    A  TV+ 
Sbjct: 1431 TEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVIT 1490

Query: 649  IAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIRRQALD 696
            IAHRL T+  +  ++V+ +G++ E G+ EELL+  G +  + +   ++
Sbjct: 1491 IAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGIE 1538



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 61/223 (27%), Positives = 112/223 (50%), Gaps = 20/223 (8%)

Query: 473 LKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQ 532
           ++D  L +  G++VA++G  G GK+++ S +    +   G + + G        SW++  
Sbjct: 654 VRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNG 713

Query: 533 VVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREANAH-EFITSFPEGYNTVVGER 591
            +    ++ +LFGT              +E+ Y    EA A    +   P G    +GE+
Sbjct: 714 TI----KDNILFGTEF------------NEKRYQQVLEACALLPDLEMLPGGDLAEIGEK 757

Query: 592 GTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAE-SERVVQEAL--DRASAGRTVLV 648
           G  LSGGQKQR+++ARA  +   + +LD+  SA+DA   + +  + L  +    G+T L+
Sbjct: 758 GINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLL 817

Query: 649 IAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIR 691
           + H +  +     IVV+ +G + E G++  LL K G +A+ ++
Sbjct: 818 VTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLK 860


>gi|110832837 ATP-binding cassette, sub-family C, member 9 isoform
            SUR2B [Homo sapiens]
          Length = 1549

 Score =  148 bits (374), Expect = 2e-35
 Identities = 153/611 (25%), Positives = 269/611 (44%), Gaps = 39/611 (6%)

Query: 97   EAEEAPPASSTPHVVGSRFNWKLFWQFLHP---HLLVLGVAVVLALGAALVNVQIPLLLG 153
            E E+     ST   + ++  WK  W++L      LL+L +   L   + +V +       
Sbjct: 959  EEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDY----- 1013

Query: 154  QLVEVVAKYTRDHVGSFMTESQNLSTHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRRA 213
             L    ++Y+ ++ G    +         IL G    L     + +  +G   A ++   
Sbjct: 1014 WLATWTSEYSINNTGK--ADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHN 1071

Query: 214  LFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSML 273
            L + ++   I FFD    G +++R + D           +    RS      CL ++ M+
Sbjct: 1072 LLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLL---CLSAIGMI 1128

Query: 274  STRLTLLLMVATPALMGVGT-LMGSGLRKLSRQCQE-----QIARAMGVADEALGNVRTV 327
            S    + L+   P  +GV    +    R  S+  QE     Q+      ++ A G + T+
Sbjct: 1129 SYATPVFLVALLP--LGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEG-LTTI 1185

Query: 328  RAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQ 387
            RAF  E R ++R     +        L       +  ++    C+VL       S  +  
Sbjct: 1186 RAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNS 1245

Query: 388  QLTGGDLMSFLVASQT---VQRSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGC 444
             L G  L+  L  +     V R++A+L V  G V +  S     F  M            
Sbjct: 1246 GLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNS-----FLTMESENYEGTMDPS 1300

Query: 445  CVPKE-QLRGSVTFQNVCFSYP--CRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVAS 501
             VP+     G +   ++C  Y    +P   VLK     + PG+ V + G++G GK++++ 
Sbjct: 1301 QVPEHWPQEGEIKIHDLCVRYENNLKP---VLKHVKAYIKPGQKVGICGRTGSGKSSLSL 1357

Query: 502  LLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASD 561
               R  D   G +++DG D+  L    LR ++   I Q+P+LF  +I  N+   + + +D
Sbjct: 1358 AFFRMVDIFDGKIVIDGIDISKLPLHTLRSRL-SIILQDPILFSGSIRFNLD-PECKCTD 1415

Query: 562  EEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEA 621
            + ++ A   A     + S P G + VV E G   S GQ+Q   +ARA +++ ++LI+DEA
Sbjct: 1416 DRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEA 1475

Query: 622  TSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELL- 680
            T+++D  +E ++Q+ +  A A RTV+ IAHR+ T+  A  ++VM  G + E  T E LL 
Sbjct: 1476 TASIDMATENILQKVVMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLA 1535

Query: 681  KKGGLYAELIR 691
            ++ G++A  +R
Sbjct: 1536 QENGVFASFVR 1546



 Score = 96.3 bits (238), Expect = 9e-20
 Identities = 68/223 (30%), Positives = 115/223 (51%), Gaps = 13/223 (5%)

Query: 469 GFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSW 528
           G   L +  + +P G++  +VGQ G GK+++   +        G V     ++   +PS+
Sbjct: 684 GLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWS--NVNESEPSF 741

Query: 529 LRGQV-----VGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREA-NAHEFITSFPE 582
              +      V + +Q+P L   T+ ENI FG     +++ Y A  +A +    I   P 
Sbjct: 742 EATRSRNRYSVAYAAQKPWLLNATVEENITFGS--PFNKQRYKAVTDACSLQPDIDLLPF 799

Query: 583 GYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAE-SERVVQEALDR-- 639
           G  T +GERG  LSGGQ+QR+ +ARAL +   ++ LD+  SALD   S+ ++QE + +  
Sbjct: 800 GDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFL 859

Query: 640 ASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKK 682
               RT++++ H+L  +  A  I+ M DG V   GT +++  K
Sbjct: 860 QDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTK 902


>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
            [Homo sapiens]
          Length = 1527

 Score =  145 bits (366), Expect = 1e-34
 Identities = 148/543 (27%), Positives = 262/543 (48%), Gaps = 34/543 (6%)

Query: 171  MTESQNLSTHLLI-LYGVQGLLTFGYLVLLSHV-----GERMAVDMRRALFSSLLRQDIT 224
            M +S+  +T L + +Y   G+L  G+LV+L+ +     G + A  + +AL  + +R   +
Sbjct: 1000 MADSRQNNTSLRLGVYAALGILQ-GFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQS 1058

Query: 225  FFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVA 284
            FFD   +G++++  + D+         VI   L S       LV + M ST L  ++++ 
Sbjct: 1059 FFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVI-MASTPLFTVVILP 1117

Query: 285  TPALMGVGTLMGSGLRKLSRQCQ--EQIARAMGVA--DEALGNVRTVRAFAMEQREEERY 340
               L    TL+       SRQ +  E ++R+   +   E +     +RA+   +  E   
Sbjct: 1118 LAVLY---TLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIIS 1174

Query: 341  GAELEACRCRAEEL---GRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSF 397
              +++A +          R +++  G+  +  NC+VL   F     V G+      L+  
Sbjct: 1175 DTKVDANQRSCYPYIISNRWLSI--GVEFVG-NCVVL---FAALFAVIGRSSLNPGLVGL 1228

Query: 398  LVA-SQTVQRSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQL--RGS 454
             V+ S  V  ++  +  +   +   + A  RV EY       P       P E    RG 
Sbjct: 1229 SVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGE 1288

Query: 455  VTFQNVCFSYPCRPGFE-VLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGV 513
            V F+N    Y  RPG + VL+D +L +  G+ V +VG++G GK+++   L R  +   G 
Sbjct: 1289 VEFRNYSVRY--RPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGE 1346

Query: 514  VMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIR-FGKLEASDEEVYTAAREAN 572
            + +DG ++  +    LR Q+   I Q+P+LF  T+  N+  FG    S+E+++ A   ++
Sbjct: 1347 IRIDGLNVADIGLHDLRSQLT-IIPQDPILFSGTLRMNLDPFGSY--SEEDIWWALELSH 1403

Query: 573  AHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERV 632
             H F++S P G +    E G  LS GQ+Q + +ARAL+++  +L+LDEAT+A+D E++ +
Sbjct: 1404 LHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNL 1463

Query: 633  VQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIRR 692
            +Q  +       TVL IAHRL+T+     ++V+  G V E  +   L+   G++  + R 
Sbjct: 1464 IQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFYGMARD 1523

Query: 693  QAL 695
              L
Sbjct: 1524 AGL 1526



 Score = 99.8 bits (247), Expect = 8e-21
 Identities = 68/228 (29%), Positives = 117/228 (51%), Gaps = 20/228 (8%)

Query: 473 LKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQ 532
           L    + +P G +VA+VG  G GK+++ S L    +   G V + G              
Sbjct: 644 LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGS------------- 690

Query: 533 VVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREANAH-EFITSFPEGYNTVVGER 591
            V ++ Q+  +   T+ EN+ FGK  A + + Y    EA A    +   P G  T +GE+
Sbjct: 691 -VAYVPQQAWIQNCTLQENVLFGK--ALNPKRYQQTLEACALLADLEMLPGGDQTEIGEK 747

Query: 592 GTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEAL---DRASAGRTVLV 648
           G  LSGGQ+QR+++ARA+     + +LD+  SA+D+   + + + +   +   AG+T ++
Sbjct: 748 GINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVL 807

Query: 649 IAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIRRQALD 696
           + H +S +     I+V+ADG+V E G +  LL++ G +A  +   A D
Sbjct: 808 VTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPD 855


>gi|110832839 ATP-binding cassette, sub-family C, member 9 isoform
            SUR2A-delta-14 [Homo sapiens]
          Length = 1513

 Score =  144 bits (364), Expect = 2e-34
 Identities = 152/610 (24%), Positives = 269/610 (44%), Gaps = 39/610 (6%)

Query: 97   EAEEAPPASSTPHVVGSRFNWKLFWQFLHP---HLLVLGVAVVLALGAALVNVQIPLLLG 153
            E E+     ST   + ++  WK  W++L      LL+L +   L   + +V +       
Sbjct: 923  EEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDY----- 977

Query: 154  QLVEVVAKYTRDHVGSFMTESQNLSTHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRRA 213
             L    ++Y+ ++ G    +         IL G    L     + +  +G   A ++   
Sbjct: 978  WLATWTSEYSINNTGK--ADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHN 1035

Query: 214  LFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSML 273
            L + ++   I FFD    G +++R + D           +    RS      CL ++ M+
Sbjct: 1036 LLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLL---CLSAIGMI 1092

Query: 274  STRLTLLLMVATPALMGVGT-LMGSGLRKLSRQCQE-----QIARAMGVADEALGNVRTV 327
            S    + L+   P  +GV    +    R  S+  QE     Q+      ++ A G + T+
Sbjct: 1093 SYATPVFLVALLP--LGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEG-LTTI 1149

Query: 328  RAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQ 387
            RAF  E R ++R     +        L       +  ++    C+VL       S  +  
Sbjct: 1150 RAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNS 1209

Query: 388  QLTGGDLMSFLVASQT---VQRSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGC 444
             L G  L+  L  +     V R++A+L V  G V +  S     F  M            
Sbjct: 1210 GLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNS-----FLTMESENYEGTMDPS 1264

Query: 445  CVPKE-QLRGSVTFQNVCFSYP--CRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVAS 501
             VP+     G +   ++C  Y    +P   VLK     + PG+ V + G++G GK++++ 
Sbjct: 1265 QVPEHWPQEGEIKIHDLCVRYENNLKP---VLKHVKAYIKPGQKVGICGRTGSGKSSLSL 1321

Query: 502  LLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASD 561
               R  D   G +++DG D+  L    LR ++   I Q+P+LF  +I  N+   + + +D
Sbjct: 1322 AFFRMVDIFDGKIVIDGIDISKLPLHTLRSRL-SIILQDPILFSGSIRFNLD-PECKCTD 1379

Query: 562  EEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEA 621
            + ++ A   A     + S P G + VV E G   S GQ+Q   +ARA +++ ++LI+DEA
Sbjct: 1380 DRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEA 1439

Query: 622  TSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELL- 680
            T+++D  +E ++Q+ +  A A RTV+ IAHR+S++  A  ++V ++G + E  T   LL 
Sbjct: 1440 TASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLA 1499

Query: 681  KKGGLYAELI 690
             K GL++ L+
Sbjct: 1500 HKNGLFSTLV 1509



 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 107/428 (25%), Positives = 190/428 (44%), Gaps = 45/428 (10%)

Query: 288 LMGVGTLMGSGLRKLSRQCQEQIARAMGVA---------------DEALGNVRTVRAFAM 332
           L+G   L+G+ +  L    Q  IA  +  A               +E L  ++ ++ +A 
Sbjct: 451 LLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAW 510

Query: 333 EQREEERYGAELEACRCRAEELGRGIALFQGLS---NIAFNCMVLGTLFIGGSLVAGQQL 389
           E      +   +E  R +     +  AL+  LS   N A     +   F+  +  +G  L
Sbjct: 511 EHI----FCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNL 566

Query: 390 TGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLS---GGCCV 446
              +  + L     +   +  LS +    V+ + +  ++ E++  +     S   G   +
Sbjct: 567 KPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSL 626

Query: 447 PKEQLR---GSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLL 503
           P E  +   G VT  N  FS+    G   L +  + +P G++  +VGQ G GK+++   +
Sbjct: 627 PFESCKKHTGVVT--NGYFSWGS--GLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAI 682

Query: 504 ERFYDPTAGVVMLDGRDLRTLDPSWLRGQV-----VGFISQEPVLFGTTIMENIRFGKLE 558
                   G V     ++   +PS+   +      V + +Q+P L   T+ ENI FG   
Sbjct: 683 LGEMQTLEGKVHWS--NVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGS-- 738

Query: 559 ASDEEVYTAAREA-NAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLI 617
             +++ Y A  +A +    I   P G  T +GERG  LSGGQ+QR+ +ARAL +   ++ 
Sbjct: 739 PFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVF 798

Query: 618 LDEATSALDAE-SERVVQEALDR--ASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAG 674
           LD+  SALD   S+ ++QE + +      RT++++ H+L  +  A  I+ M DG V   G
Sbjct: 799 LDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREG 858

Query: 675 THEELLKK 682
           T +++  K
Sbjct: 859 TLKDIQTK 866


>gi|110832835 ATP-binding cassette, sub-family C, member 9 isoform
            SUR2A [Homo sapiens]
          Length = 1549

 Score =  144 bits (364), Expect = 2e-34
 Identities = 152/610 (24%), Positives = 269/610 (44%), Gaps = 39/610 (6%)

Query: 97   EAEEAPPASSTPHVVGSRFNWKLFWQFLHP---HLLVLGVAVVLALGAALVNVQIPLLLG 153
            E E+     ST   + ++  WK  W++L      LL+L +   L   + +V +       
Sbjct: 959  EEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDY----- 1013

Query: 154  QLVEVVAKYTRDHVGSFMTESQNLSTHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRRA 213
             L    ++Y+ ++ G    +         IL G    L     + +  +G   A ++   
Sbjct: 1014 WLATWTSEYSINNTGK--ADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHN 1071

Query: 214  LFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSML 273
            L + ++   I FFD    G +++R + D           +    RS      CL ++ M+
Sbjct: 1072 LLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLL---CLSAIGMI 1128

Query: 274  STRLTLLLMVATPALMGVGT-LMGSGLRKLSRQCQE-----QIARAMGVADEALGNVRTV 327
            S    + L+   P  +GV    +    R  S+  QE     Q+      ++ A G + T+
Sbjct: 1129 SYATPVFLVALLP--LGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEG-LTTI 1185

Query: 328  RAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQ 387
            RAF  E R ++R     +        L       +  ++    C+VL       S  +  
Sbjct: 1186 RAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNS 1245

Query: 388  QLTGGDLMSFLVASQT---VQRSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGC 444
             L G  L+  L  +     V R++A+L V  G V +  S     F  M            
Sbjct: 1246 GLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNS-----FLTMESENYEGTMDPS 1300

Query: 445  CVPKE-QLRGSVTFQNVCFSYP--CRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVAS 501
             VP+     G +   ++C  Y    +P   VLK     + PG+ V + G++G GK++++ 
Sbjct: 1301 QVPEHWPQEGEIKIHDLCVRYENNLKP---VLKHVKAYIKPGQKVGICGRTGSGKSSLSL 1357

Query: 502  LLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASD 561
               R  D   G +++DG D+  L    LR ++   I Q+P+LF  +I  N+   + + +D
Sbjct: 1358 AFFRMVDIFDGKIVIDGIDISKLPLHTLRSRL-SIILQDPILFSGSIRFNLD-PECKCTD 1415

Query: 562  EEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEA 621
            + ++ A   A     + S P G + VV E G   S GQ+Q   +ARA +++ ++LI+DEA
Sbjct: 1416 DRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEA 1475

Query: 622  TSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELL- 680
            T+++D  +E ++Q+ +  A A RTV+ IAHR+S++  A  ++V ++G + E  T   LL 
Sbjct: 1476 TASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLA 1535

Query: 681  KKGGLYAELI 690
             K GL++ L+
Sbjct: 1536 HKNGLFSTLV 1545



 Score = 96.3 bits (238), Expect = 9e-20
 Identities = 68/223 (30%), Positives = 115/223 (51%), Gaps = 13/223 (5%)

Query: 469 GFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSW 528
           G   L +  + +P G++  +VGQ G GK+++   +        G V     ++   +PS+
Sbjct: 684 GLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWS--NVNESEPSF 741

Query: 529 LRGQV-----VGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREA-NAHEFITSFPE 582
              +      V + +Q+P L   T+ ENI FG     +++ Y A  +A +    I   P 
Sbjct: 742 EATRSRNRYSVAYAAQKPWLLNATVEENITFGS--PFNKQRYKAVTDACSLQPDIDLLPF 799

Query: 583 GYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAE-SERVVQEALDR-- 639
           G  T +GERG  LSGGQ+QR+ +ARAL +   ++ LD+  SALD   S+ ++QE + +  
Sbjct: 800 GDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFL 859

Query: 640 ASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKK 682
               RT++++ H+L  +  A  I+ M DG V   GT +++  K
Sbjct: 860 QDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTK 902


>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
            [Homo sapiens]
          Length = 1325

 Score =  139 bits (350), Expect = 9e-33
 Identities = 147/550 (26%), Positives = 259/550 (47%), Gaps = 51/550 (9%)

Query: 168  GSFMTESQNLSTHLLILYGVQ-GLLTFGYL--VLLSHVGERMAVDMRRALFSSLLRQDIT 224
            G  +TE  +L+ +L I  G+    + FG    +L+ +V    +  +   +F S+L+  + 
Sbjct: 752  GGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVL 811

Query: 225  FFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVA 284
            FFD N  G++++R + D+        L     +++  QV G      ++S  + ++  +A
Sbjct: 812  FFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVG------VVSVAVAVIPWIA 865

Query: 285  TPALMGVGTLMGSGLRKLSRQCQEQIARAMGVA--------DEALGNVRTVRAFAMEQRE 336
             P L+ +G +    LR+   +    + R               +L  + T+RA+  E+R 
Sbjct: 866  IP-LVPLGIIF-IFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERC 923

Query: 337  EERYGAE-----------LEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVA 385
            +E + A            L   R  A  L    A+F  +  +AF     G+L +  +L A
Sbjct: 924  QELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVII--VAF-----GSLILAKTLDA 976

Query: 386  GQQLTGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCC 445
            GQ    G  +S+ +    + +     S    +V   + +  RV EY  L    P      
Sbjct: 977  GQV---GLALSYALTLMGMFQWCVRQSA---EVENMMISVERVIEYTDLEKEAPWEYQKR 1030

Query: 446  VPKE-QLRGSVTFQNVCFSYPCRPGFE-VLKDFTLTLPPGKIVALVGQSGGGKTTVASLL 503
             P      G + F NV F Y   PG   VLK  T  +   + V +VG++G GK+++ S L
Sbjct: 1031 PPPAWPHEGVIIFDNVNFMYS--PGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISAL 1088

Query: 504  ERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEE 563
             R  +P  G + +D      +    LR ++   I QEPVLF  T+ +N+     E +DEE
Sbjct: 1089 FRLSEPE-GKIWIDKILTTEIGLHDLRKKM-SIIPQEPVLFTGTMRKNLDPFN-EHTDEE 1145

Query: 564  VYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATS 623
            ++ A +E    E I   P   +T + E G+  S GQ+Q + +ARA++++  +LI+DEAT+
Sbjct: 1146 LWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATA 1205

Query: 624  ALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLK-K 682
             +D  ++ ++Q+ +    A  TVL IAHRL+T+  +  I+V+  GR+ E      LL+ K
Sbjct: 1206 NVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNK 1265

Query: 683  GGLYAELIRR 692
              L+ +++++
Sbjct: 1266 ESLFYKMVQQ 1275



 Score =  129 bits (325), Expect = 7e-30
 Identities = 141/604 (23%), Positives = 264/604 (43%), Gaps = 63/604 (10%)

Query: 118 KLFWQFLHPHLLVLGVAVVLALGAALVNVQIPLLLGQLVEVVAKYT-RDHVGSFMTESQN 176
           K +W+      LVLG+  ++   A ++    P+ LG+++     Y   D V   +  +  
Sbjct: 86  KCYWK----SYLVLGIFTLIEESAKVIQ---PIFLGKIINYFENYDPMDSVA--LNTAYA 136

Query: 177 LSTHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVS 236
            +T L     +  +L   Y   +   G R+ V M   ++   LR          TGQ+V+
Sbjct: 137 YATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVN 196

Query: 237 RLTTDVQEFK--SSFKLVISQGLRSCTQVAGCL---VSLSMLSTRLTLLLMVATPALMGV 291
            L+ DV +F   + F   +  G      V   L   + +S L+    L++++   +  G 
Sbjct: 197 LLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGK 256

Query: 292 GTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQ---------REEERYGA 342
              + S LR  +    +   R M   +E +  +R ++ +A E+         R++E    
Sbjct: 257 ---LFSSLRSKTATFTDARIRTM---NEVITGIRIIKMYAWEKSFSNLITNLRKKEISKI 310

Query: 343 ELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQ 402
              +C       G  +A F   S I         + +G  + A +      L   +  + 
Sbjct: 311 LRSSCL-----RGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTV 365

Query: 403 TVQRSMANLSVLFGQV-VRGLSAGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVC 461
           T+    A   V    V +R +     + E    N  +P  G   V    ++    F +  
Sbjct: 366 TLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMV---HVQDFTAFWDKA 422

Query: 462 FSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDL 521
              P       L+  + T+ PG+++A+VG  G GK+++ S +     P+ G+V + GR  
Sbjct: 423 SETP------TLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGR-- 474

Query: 522 RTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREANA-HEFITSF 580
                       + ++SQ+P +F  T+  NI FGK    ++E Y    +A A  + +   
Sbjct: 475 ------------IAYVSQQPWVFSGTLRSNILFGK--KYEKERYEKVIKACALKKDLQLL 520

Query: 581 PEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAE-SERVVQEALDR 639
            +G  TV+G+RGTTLSGGQK R+ +ARA+ +   + +LD+  SA+DAE S  + +  + +
Sbjct: 521 EDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQ 580

Query: 640 ASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIRRQALDAPR 699
               +  +++ H+L  ++ A  I+++ DG++ + GT+ E LK G  +  L+++   ++ +
Sbjct: 581 ILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQ 640

Query: 700 TAAP 703
              P
Sbjct: 641 PPVP 644


>gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo
            sapiens]
          Length = 1581

 Score =  139 bits (349), Expect = 1e-32
 Identities = 132/523 (25%), Positives = 243/523 (46%), Gaps = 55/523 (10%)

Query: 197  VLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSFKLVISQG 256
            V +   G ++A  + R+L + ++   + FF+    G +++R ++D           +   
Sbjct: 1083 VTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECL 1142

Query: 257  LRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQE-----QIA 311
             RS      C+ +L+++S  +T + +VA   L  V   +    R  SR  Q+     Q+ 
Sbjct: 1143 SRSTLL---CVSALAVISY-VTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLP 1198

Query: 312  RAMGVADEALGNVRTVRAFAMEQREEERYGAELEA--------------CRCRAEELGRG 357
                 A+   G + T+RAF  E R +++     ++                 R E +G  
Sbjct: 1199 LLSHFAETVEG-LTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGAC 1257

Query: 358  IALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQ---RSMANLSVL 414
            + L   +++I+ +        +   L AG  L G  L   L+ S  +    R++A++ + 
Sbjct: 1258 VVLIAAVTSISNS--------LHRELSAG--LVGLGLTYALMVSNYLNWMVRNLADMELQ 1307

Query: 415  FGQVVRG---LSAGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPC--RPG 469
             G V R    L   A  +E +     IP +     P +   G +  QN+   Y    +P 
Sbjct: 1308 LGAVKRIHGLLKTEAESYEGLLAPSLIPKNW----PDQ---GKIQIQNLSVRYDSSLKP- 1359

Query: 470  FEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWL 529
              VLK     + PG+ + + G++G GK++ +    R  D   G +++DG D+  L    L
Sbjct: 1360 --VLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTL 1417

Query: 530  RGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEGYNTVVG 589
            R ++   I Q+PVLF  TI  N+   + + SD  ++ A   A     + + P G + ++ 
Sbjct: 1418 RSRL-SIILQDPVLFSGTIRFNLD-PERKCSDSTLWEALEIAQLKLVVKALPGGLDAIIT 1475

Query: 590  ERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVI 649
            E G   S GQ+Q   +ARA +++ ++ I+DEAT+++D  +E ++Q+ +  A A RTV+ I
Sbjct: 1476 EGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTI 1535

Query: 650  AHRLSTVRGAHCIVVMADGRVWEAGTHEELL-KKGGLYAELIR 691
            AHR+ T+  A  ++V+  G + E    E+LL +K  ++A  +R
Sbjct: 1536 AHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDSVFASFVR 1578



 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 77/264 (29%), Positives = 121/264 (45%), Gaps = 22/264 (8%)

Query: 469 GFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTL--DP 526
           G   L + T+ +P G++  +VGQ G GK+++           +G V         +  DP
Sbjct: 692 GIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDP 751

Query: 527 SWLRGQV----------VGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREA-NAHE 575
           S  R             V + SQ+P L   T+ ENI F      +++ Y    EA +   
Sbjct: 752 SPERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFES--PFNKQRYKMVIEACSLQP 809

Query: 576 FITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAE-SERVVQ 634
            I   P G  T +GERG  LSGGQ+QR+++ARAL +   V+ LD+  SALD   S+ ++Q
Sbjct: 810 DIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQ 869

Query: 635 EALDR--ASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAE---- 688
             +        RTV+++ H+L  +  A  I+ M DG +   GT ++  +      E    
Sbjct: 870 AGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKT 929

Query: 689 LIRRQALDAPRTAAPPPKKPEGPR 712
           L+ RQ  +  +      K  E P+
Sbjct: 930 LMNRQDQELEKETVTERKATEPPQ 953


>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
            [Homo sapiens]
          Length = 1437

 Score =  138 bits (348), Expect = 2e-32
 Identities = 135/490 (27%), Positives = 225/490 (45%), Gaps = 48/490 (9%)

Query: 214  LFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSML 273
            LF  +LR  + FFD   TG++++R + D+ E            +++   V  C+    M+
Sbjct: 951  LFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCV---GMI 1007

Query: 274  STRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADE--------ALGNVR 325
            +      L+   P +     ++ S L  +SR    ++ R   +           ++  + 
Sbjct: 1008 AGVFPWFLVAVGPLV-----ILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLA 1062

Query: 326  TVRAFAMEQREEERYGAELE-----------ACRCRAEELGR-GIALFQ--GLSNIAFNC 371
            T+ A+   Q    RY   L+           A R  A  L    IAL    GL  +  + 
Sbjct: 1063 TIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHG 1122

Query: 372  MVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGARVFEY 431
             +    + G ++    QLTG    +  +AS+T  R  +   +        L A AR+ + 
Sbjct: 1123 QI-PPAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARI-KN 1180

Query: 432  MALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFE-VLKDFTLTLPPGKIVALVG 490
             A +P  P  G            VTF+N    Y  R     VLK  + T+ P + + +VG
Sbjct: 1181 KAPSPDWPQEG-----------EVTFENAEMRY--RENLPLVLKKVSFTIKPKEKIGIVG 1227

Query: 491  QSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIME 550
            ++G GK+++   L R  + + G + +DG  +  +  + LR ++   I QEPVLF  T+  
Sbjct: 1228 RTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKL-SIIPQEPVLFSGTVRS 1286

Query: 551  NIRFGKLEASDEEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALI 610
            N+     + ++++++ A    +  E I   P    + V E G   S G++Q L IARAL+
Sbjct: 1287 NLDPFN-QYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALL 1345

Query: 611  KQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRV 670
            +   +LILDEAT+A+D E++ ++QE +  A A  T+L IAHRL TV G+  I+V+A G+V
Sbjct: 1346 RHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQV 1405

Query: 671  WEAGTHEELL 680
             E  T   LL
Sbjct: 1406 VEFDTPSVLL 1415



 Score =  105 bits (262), Expect = 1e-22
 Identities = 66/224 (29%), Positives = 105/224 (46%), Gaps = 16/224 (7%)

Query: 473 LKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQ 532
           L    L +  GK+V + G  G GKT++ S +        G + + G              
Sbjct: 578 LHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISG-------------- 623

Query: 533 VVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEGYNTVVGERG 592
              +++Q+  +   T+ +NI FGK E  +E   +          +   P    T +GERG
Sbjct: 624 TFAYVAQQAWILNATLRDNILFGK-EYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERG 682

Query: 593 TTLSGGQKQRLAIARALIKQPTVLILDEATSALDAE-SERVVQEALDRASAGRTVLVIAH 651
             LSGGQ+QR+++ARAL    ++ ILD+  SALDA     +   A+ +    +TVL + H
Sbjct: 683 ANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTH 742

Query: 652 RLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIRRQAL 695
           +L  +     ++ M +G + E GTHEEL+   G YA +     L
Sbjct: 743 QLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLL 786


>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 1312

 Score =  135 bits (341), Expect = 1e-31
 Identities = 138/503 (27%), Positives = 222/503 (44%), Gaps = 37/503 (7%)

Query: 212  RALFSSLL----RQDITFFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCL 267
            R LF  LL    R  I+FF+    G L++R + +      +  + I   LRS    A  L
Sbjct: 827  RLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETD----TVDVDIPDKLRSLLMYAFGL 882

Query: 268  VSLSM-------LSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEA 320
            + +S+       L+T   L L +       +  +    LR+L       +   M    + 
Sbjct: 883  LEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQG 942

Query: 321  LGNVRTVRA---FAMEQREEERYGAELEACRCRAEE-LGRGIALF-QGLSNIAFNCMVLG 375
               VR  R    F  +          +   R  A+  L   + L   GL   A  C VL 
Sbjct: 943  STVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLS 1002

Query: 376  TLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGARVFEYMALN 435
               +   LV      G  + + L  +QT+Q  + N + L   +V    +  R+ +Y    
Sbjct: 1003 KAHLSAGLV------GFSVSAALQVTQTLQWVVRNWTDLENSIV----SVERMQDYAWTP 1052

Query: 436  PCIPLSGGCCV--PKEQLRGSVTFQNVCFSYPCRPGFEV-LKDFTLTLPPGKIVALVGQS 492
               P     C   P     G + FQ+    Y  RP   + ++  +  +  G+ V +VG++
Sbjct: 1053 KEAPWRLPTCAAQPPWPQGGQIEFQDFGLRY--RPELPLAVQGVSFKIHAGEKVGIVGRT 1110

Query: 493  GGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENI 552
            G GK+++AS L R  +   G + +DG  +  +    LR ++   I Q+P+LF  ++  N+
Sbjct: 1111 GAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRI-SIIPQDPILFPGSLRMNL 1169

Query: 553  RFGKLEASDEEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQ 612
               + E SDE ++ A         + S P        +RG  LS GQKQ L +ARAL+++
Sbjct: 1170 DLLQ-EHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRK 1228

Query: 613  PTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWE 672
              +LILDEAT+A+D  +E  +Q  L    A  TVL+IAHRL +V     ++VM  G+V E
Sbjct: 1229 TQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAE 1288

Query: 673  AGTHEELLKKGGLYAELIRRQAL 695
            +G+  +LL + GL+  L +   L
Sbjct: 1289 SGSPAQLLAQKGLFYRLAQESGL 1311



 Score =  122 bits (305), Expect = 2e-27
 Identities = 144/617 (23%), Positives = 253/617 (41%), Gaps = 64/617 (10%)

Query: 118 KLFWQFLHPHLLVLGVAVVLALGAALVNVQIPLLLGQLVEVVAKYTRDH-VGSFMTESQN 176
           K  WQ  H   L+  ++++++    +    +P LL   +E +         G  +     
Sbjct: 110 KAIWQVFHSTFLLGTLSLIIS---DVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMF 166

Query: 177 LSTHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVS 236
           LS  L  L+  Q +     L +      R+   +   ++  +L        A+  G +V+
Sbjct: 167 LSACLQTLFEQQNMYRLKVLQM------RLRSAITGLVYRKVLALSSGSRKASAVGDVVN 220

Query: 237 RLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMG 296
            ++ DVQ    S  L ++        +  C V L  L     L  +    +L+ +   + 
Sbjct: 221 LVSVDVQRLTESV-LYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFIS 279

Query: 297 SGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELE-ACRCRAEELG 355
                   +   Q      +    L N +T++    E       GA L+     R +ELG
Sbjct: 280 KKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWE-------GAFLDRVLGIRGQELG 332

Query: 356 --RGIALFQGLSNIAFNC---MVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMAN 410
             R   L   +S ++F     +V   +F   +LVA   +        L     + ++ A 
Sbjct: 333 ALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAMNAEKAFVTLTVLNILNKAQAF 392

Query: 411 LSVLFGQVVRGLSAGARVFEYMALNPCIP-----LSGGCCVPKEQLRGSVTFQNVCFSY- 464
           L      +V+   +  R+  ++ L    P      S G    K+     +T Q+  F++ 
Sbjct: 393 LPFSIHSLVQARVSFDRLVTFLCLEEVDPGAVDSSSSGSAAGKD----CITIQSATFAWS 448

Query: 465 ----PCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRD 520
               PC      L    LT+P G ++A+VG  G GK+++ S L        G V ++G  
Sbjct: 449 QESPPC------LHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEG-- 500

Query: 521 LRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREANAHEFITSF 580
                        V ++ QE  +  T+++EN+ FG+ E     +            + SF
Sbjct: 501 ------------AVAYVPQEAWVQNTSVVENVCFGQ-ELDPPWLERVLEACALQPDVDSF 547

Query: 581 PEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAE-SERVVQEALDR 639
           PEG +T +GE+G  LSGGQKQRL++ARA+ ++  V +LD+  +ALDA   + V  + +  
Sbjct: 548 PEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGP 607

Query: 640 AS--AGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELI--RRQAL 695
                G T +++ H L  +  A  I+V+A+G + E G+++ELL++ G    L+   RQ  
Sbjct: 608 GGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQPG 667

Query: 696 DAPRTAAPPPKKPEGPR 712
           D       P    + PR
Sbjct: 668 DRGEGETEPGTSTKDPR 684


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.137    0.409 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,177,947
Number of Sequences: 37866
Number of extensions: 1126412
Number of successful extensions: 3744
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 82
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 3393
Number of HSP's gapped (non-prelim): 173
length of query: 718
length of database: 18,247,518
effective HSP length: 110
effective length of query: 608
effective length of database: 14,082,258
effective search space: 8562012864
effective search space used: 8562012864
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.