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Search of human proteins with 156071470
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|156071470 hyperpolarization activated cyclic
nucleotide-gated potassium channel 2 [Homo sapiens]
(889 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|156071470 hyperpolarization activated cyclic nucleotide-gated... 1820 0.0
gi|4885407 hyperpolarization activated cyclic nucleotide-gated p... 1068 0.0
gi|116325989 hyperpolarization activated cyclic nucleotide-gated... 999 0.0
gi|38327037 hyperpolarization activated cyclic nucleotide-gated ... 909 0.0
gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2 [... 181 2e-45
gi|13540549 potassium voltage-gated channel, subfamily H, member... 180 5e-45
gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Ho... 180 6e-45
gi|27886653 potassium voltage-gated channel, subfamily H, member... 173 6e-43
gi|26051273 voltage-gated potassium channel, subfamily H, member... 173 7e-43
gi|4557729 voltage-gated potassium channel, subfamily H, member ... 173 7e-43
gi|4504831 potassium voltage-gated channel, subfamily H, member ... 173 7e-43
gi|6912446 potassium voltage-gated channel, subfamily H, member ... 169 8e-42
gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens] 169 1e-41
gi|22024390 potassium voltage-gated channel, subfamily H, member... 168 2e-41
gi|27886648 potassium voltage-gated channel, subfamily H, member... 168 2e-41
gi|27886651 potassium voltage-gated channel, subfamily H, member... 168 2e-41
gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens] 167 4e-41
gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1 [... 166 1e-40
gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [H... 166 1e-40
gi|27437001 potassium voltage-gated channel, subfamily H, member... 165 2e-40
gi|27886667 potassium voltage-gated channel, subfamily H, member... 160 4e-39
gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [H... 157 3e-38
gi|38569493 potassium voltage-gated channel, subfamily H (eag-re... 154 5e-37
gi|26051271 voltage-gated potassium channel, subfamily H, member... 150 4e-36
gi|27886646 potassium voltage-gated channel, subfamily H, member... 149 1e-35
gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens] 134 4e-31
gi|27886665 potassium voltage-gated channel, subfamily H, member... 132 1e-30
gi|4826998 splicing factor proline/glutamine rich (polypyrimidin... 80 8e-15
gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1 pre... 72 2e-12
gi|32307177 forkhead box G1 [Homo sapiens] 72 2e-12
>gi|156071470 hyperpolarization activated cyclic nucleotide-gated
potassium channel 2 [Homo sapiens]
Length = 889
Score = 1820 bits (4715), Expect = 0.0
Identities = 889/889 (100%), Positives = 889/889 (100%)
Query: 1 MDARGGGGRPGESPGATPAPGPPPPPPPAPPQQQPPPPPPPAPPPGPGPAPPQHPPRAEA 60
MDARGGGGRPGESPGATPAPGPPPPPPPAPPQQQPPPPPPPAPPPGPGPAPPQHPPRAEA
Sbjct: 1 MDARGGGGRPGESPGATPAPGPPPPPPPAPPQQQPPPPPPPAPPPGPGPAPPQHPPRAEA 60
Query: 61 LPPEAADEGGPRGRLRSRDSSCGRPGTPGAASTAKGSPNGECGRGEPQCSPAGPEGPARG 120
LPPEAADEGGPRGRLRSRDSSCGRPGTPGAASTAKGSPNGECGRGEPQCSPAGPEGPARG
Sbjct: 61 LPPEAADEGGPRGRLRSRDSSCGRPGTPGAASTAKGSPNGECGRGEPQCSPAGPEGPARG 120
Query: 121 PKVSFSCRGAASGPAPGPGPAEEAGSEEAGPAGEPRGSQASFMQRQFGALLQPGVNKFSL 180
PKVSFSCRGAASGPAPGPGPAEEAGSEEAGPAGEPRGSQASFMQRQFGALLQPGVNKFSL
Sbjct: 121 PKVSFSCRGAASGPAPGPGPAEEAGSEEAGPAGEPRGSQASFMQRQFGALLQPGVNKFSL 180
Query: 181 RMFGSQKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDET 240
RMFGSQKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDET
Sbjct: 181 RMFGSQKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDET 240
Query: 241 TAPWIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIP 300
TAPWIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIP
Sbjct: 241 TAPWIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIP 300
Query: 301 VDYIFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDL 360
VDYIFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDL
Sbjct: 301 VDYIFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDL 360
Query: 361 ASAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFPRNCWVSINGMVNHSWSELYSFALFK 420
ASAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFPRNCWVSINGMVNHSWSELYSFALFK
Sbjct: 361 ASAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFPRNCWVSINGMVNHSWSELYSFALFK 420
Query: 421 AMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKY 480
AMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKY
Sbjct: 421 AMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKY 480
Query: 481 KQVEQYMSFHKLPADFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREEIVNFNCRKLVA 540
KQVEQYMSFHKLPADFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREEIVNFNCRKLVA
Sbjct: 481 KQVEQYMSFHKLPADFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREEIVNFNCRKLVA 540
Query: 541 SMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMK 600
SMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMK
Sbjct: 541 SMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMK 600
Query: 601 LSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRL 660
LSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRL
Sbjct: 601 LSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRL 660
Query: 661 DRIGKKNSILLHKVQHDLNSGVFNNQENAIIQEIVKYDREMVQQAELGQRVGLFPPPPPP 720
DRIGKKNSILLHKVQHDLNSGVFNNQENAIIQEIVKYDREMVQQAELGQRVGLFPPPPPP
Sbjct: 661 DRIGKKNSILLHKVQHDLNSGVFNNQENAIIQEIVKYDREMVQQAELGQRVGLFPPPPPP 720
Query: 721 PQVTSAIATLQQAAAMSFCPQVARPLVGPLALGSPRLVRRPPPGPAPAAASPGPPPPASP 780
PQVTSAIATLQQAAAMSFCPQVARPLVGPLALGSPRLVRRPPPGPAPAAASPGPPPPASP
Sbjct: 721 PQVTSAIATLQQAAAMSFCPQVARPLVGPLALGSPRLVRRPPPGPAPAAASPGPPPPASP 780
Query: 781 PGAPASPRAPRTSPYGGLPAAPLAGPALPARRLSRASRPLSASQPSLPHGAPGPAASTRP 840
PGAPASPRAPRTSPYGGLPAAPLAGPALPARRLSRASRPLSASQPSLPHGAPGPAASTRP
Sbjct: 781 PGAPASPRAPRTSPYGGLPAAPLAGPALPARRLSRASRPLSASQPSLPHGAPGPAASTRP 840
Query: 841 ASSSTPRLGPTPAARAAAPSPDRRDSASPGAAGGLDPQDSARSRLSSNL 889
ASSSTPRLGPTPAARAAAPSPDRRDSASPGAAGGLDPQDSARSRLSSNL
Sbjct: 841 ASSSTPRLGPTPAARAAAPSPDRRDSASPGAAGGLDPQDSARSRLSSNL 889
>gi|4885407 hyperpolarization activated cyclic nucleotide-gated
potassium channel 4 [Homo sapiens]
Length = 1203
Score = 1068 bits (2762), Expect = 0.0
Identities = 598/933 (64%), Positives = 651/933 (69%), Gaps = 99/933 (10%)
Query: 41 PAPPPGPGPAPPQHPPRAEALPPEAADEGGP----------------RGRLRSRDSSCGR 84
P P P P A R+ AL AAD GP RG L S S G
Sbjct: 52 PLPSPSPSAAAGGTESRSSALG--AADSEGPARGAGKSSTNGDCRRFRGSLASLGSRGGG 109
Query: 85 PGTPGAAST----------AKGSPNGECGRGEPQCSP---AGPEGPARGPKVSFSCRGAA 131
G G+ S+ + G+ GE + P A PE P + + S
Sbjct: 110 SGGTGSGSSHGHLHDSAEERRLIAEGDASPGEDRTPPGLAAEPERPGASAQPAASPPPPQ 169
Query: 132 SGPAPGPGPAEE-------------AGSEEAGPAGEPRGSQASFMQRQFGALLQPGVNKF 178
P P E+ A ++ P E R QA FMQRQFGA+LQPGVNKF
Sbjct: 170 QPPQPASASCEQPSVDTAIKVEGGAAAGDQILPEAEVRLGQAGFMQRQFGAMLQPGVNKF 229
Query: 179 SLRMFGSQKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKD 238
SLRMFGSQKAVEREQERVKSAG WIIHPYSDFRFYWD TMLL MVGNLIIIPVGITFFKD
Sbjct: 230 SLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKD 289
Query: 239 ETTAPWIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSS 298
E T PWIVFNVVSDTFFL+DLVLNFRTGIV+EDNTEIILDP++IK KYL++WF+VDF+SS
Sbjct: 290 ENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISS 349
Query: 299 IPVDYIFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTY 358
IPVDYIFLIVE IDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTY
Sbjct: 350 IPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTY 409
Query: 359 DLASAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFPRNCWVSINGMVNHSWSELYSFAL 418
DLASAV+RI NLI MMLLLCHWDGCLQFLVPMLQDFP +CWVSIN MVN+SW + YS+AL
Sbjct: 410 DLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSYAL 469
Query: 419 FKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQE 478
FKAMSHMLCIGYGRQAP M+D+WLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQE
Sbjct: 470 FKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQE 529
Query: 479 KYKQVEQYMSFHKLPADFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREEIVNFNCRKL 538
KYKQVEQYMSFHKLP D RQ+IHDYYEHRYQGKMFDE+SILGEL+ PLREEI+NFNCRKL
Sbjct: 530 KYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKL 589
Query: 539 VASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKE 598
VASMPLFANADPNFVT+MLTKL+FEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKE
Sbjct: 590 VASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKE 649
Query: 599 MKLSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAID 658
KL+DGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVA+D
Sbjct: 650 TKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALD 709
Query: 659 RLDRIGKKNSILLHKVQHDLNSGVFNNQENAIIQEIVKYDREMVQQAELGQRVGLFPPPP 718
RLDRIGKKNSILLHKVQHDLNSGVFN QEN IIQ+IV++DREM A Q P P
Sbjct: 710 RLDRIGKKNSILLHKVQHDLNSGVFNYQENEIIQQIVQHDREMAHCAHRVQAAASATPTP 769
Query: 719 PPPQVTSAIATLQQAAAMSFCPQVARPLVGPLALGSPRLVRRPPPGPAPAAASPGPPP-- 776
P T I QAAA + +A L P + RPPPG G P
Sbjct: 770 TPVIWTPLIQAPLQAAAATTSVAIALTHHPRL----PAAIFRPPPGSGLGNLGAGQTPRH 825
Query: 777 -------------PASPPGAPASPRAPRTSPY-----GGLPAAPLAGPALPARRLSRASR 818
ASP +P+ P +S + G A P LP+ S +
Sbjct: 826 LKRLQSLIPSALGSASPASSPSQVDTPSSSSFHIQQLAGFSAPAGLSPLLPSS--SSSPP 883
Query: 819 PLSASQPSLPHGAPGPAAST-------------RPASSSTPRLGP-TPAAR---AAAPSP 861
P + PS P + G AA+T +SS +P L P P AR AA PSP
Sbjct: 884 PGACGSPSAPTPSAGVAATTIAGFGHFHKALGGSLSSSDSPLLTPLQPGARSPQAAQPSP 943
Query: 862 DRRDSASPGAAGG-------LDPQDSARSRLSS 887
A PGA GG L P S+RS SS
Sbjct: 944 -----APPGARGGLGLPEHFLPPPPSSRSPSSS 971
Score = 47.4 bits (111), Expect = 6e-05
Identities = 46/139 (33%), Positives = 56/139 (40%), Gaps = 25/139 (17%)
Query: 745 PLVGPLALGSPRLVRRPPPGPAPAAASPG--------PPPPAS--PPGAPASPRAPRTSP 794
PL+ PL G+ R + P PAP A G PPPP+S P +P P
Sbjct: 924 PLLTPLQPGA-RSPQAAQPSPAPPGARGGLGLPEHFLPPPPSSRSPSSSPGQLGQPPGEL 982
Query: 795 YGGLPAAPLAGPALPARRLSRASRPLSASQPSLPHGAPGPAASTRPASSSTPRLGPTPAA 854
GL PL+ P P P PSL GA G A+ TPR G +P
Sbjct: 983 SLGLATGPLSTPETP---------PRQPEPPSLVAGASGGASPV----GFTPRGGLSPPG 1029
Query: 855 RAAAPSPDRRDSASPGAAG 873
+ P P SA P A+G
Sbjct: 1030 HSPGP-PRTFPSAPPRASG 1047
Score = 46.6 bits (109), Expect = 1e-04
Identities = 55/192 (28%), Positives = 77/192 (40%), Gaps = 27/192 (14%)
Query: 707 LGQRVGLFPPPP--------------PPPQVTSAIATLQQAAAMSFCPQVARP-LVGPLA 751
LG PPPP PP +++ +AT + + Q P LV +
Sbjct: 952 LGLPEHFLPPPPSSRSPSSSPGQLGQPPGELSLGLATGPLSTPETPPRQPEPPSLVAGAS 1011
Query: 752 LGSPRLVRRPPPGPAPAAASPGPPP--PASPPGAPASPRA----PRTSPYGGLPAAPLAG 805
G+ + P G +P SPGPP P++PP A S + P +SP
Sbjct: 1012 GGASPVGFTPRGGLSPPGHSPGPPRTFPSAPPRASGSHGSLLLPPASSPPPPQVPQRRGT 1071
Query: 806 PALPARRLSRASRPLSASQPSLPHGAPGPAASTRPASSSTPRLGPTPAARAAAPSPDRRD 865
P L RL++ + +SASQP+LP P SS G + AA P
Sbjct: 1072 PPLTPGRLTQDLKLISASQPALPQDGAQTLRRASPHSS-----GESMAAFPLFPRAG-GG 1125
Query: 866 SASPGAAGGLDP 877
S G++GGL P
Sbjct: 1126 SGGSGSSGGLGP 1137
Score = 41.2 bits (95), Expect = 0.004
Identities = 66/263 (25%), Positives = 81/263 (30%), Gaps = 80/263 (30%)
Query: 3 ARGGGGRPGESPGATPA-PGPPPP----PPPAPPQQQ----------PPPPPPPAPPPGP 47
A GG +SP TP PG P P PAPP + PPPP +P P
Sbjct: 913 ALGGSLSSSDSPLLTPLQPGARSPQAAQPSPAPPGARGGLGLPEHFLPPPPSSRSPSSSP 972
Query: 48 GP-----------------APPQHPPRAEALPPEAADEGG--------PRGRLRSRDSSC 82
G + P+ PPR P A G PRG L S
Sbjct: 973 GQLGQPPGELSLGLATGPLSTPETPPRQPEPPSLVAGASGGASPVGFTPRGGLSPPGHSP 1032
Query: 83 GRPGT-PGAASTAKGS--------------PNGECGRGEPQCSP------------AGPE 115
G P T P A A GS P RG P +P + P
Sbjct: 1033 GPPRTFPSAPPRASGSHGSLLLPPASSPPPPQVPQRRGTPPLTPGRLTQDLKLISASQPA 1092
Query: 116 GPARGPKVSFSCRGAASG---------PAPGPGPAEEAGSEEAGPAGEPRGS----QASF 162
P G + +SG P G G S GP G P G+ +
Sbjct: 1093 LPQDGAQTLRRASPHSSGESMAAFPLFPRAGGGSGGSGSSGGLGPPGRPYGAIPGQHVTL 1152
Query: 163 MQRQFGALLQPGVNKFSLRMFGS 185
++ L P ++ F R S
Sbjct: 1153 PRKTSSGSLPPPLSLFGARATSS 1175
Score = 37.4 bits (85), Expect = 0.062
Identities = 52/176 (29%), Positives = 60/176 (34%), Gaps = 33/176 (18%)
Query: 4 RGGGGRPGESPGATPA-PGPPP----------------PPPPAPPQQQPPPPPPPAPPPG 46
RGG PG SPG P PP PPPP PQ++ PP P
Sbjct: 1022 RGGLSPPGHSPGPPRTFPSAPPRASGSHGSLLLPPASSPPPPQVPQRRGTPPLTPGRLTQ 1081
Query: 47 PGPAPPQHPPRAEALPPEAADEGGPRGRLRSRDSSCGRPGTPGAASTAKGSPNGECGRGE 106
P ALP + A S +S P P A + GS G G
Sbjct: 1082 DLKLISASQP---ALPQDGAQTLRRASPHSSGESMAAFPLFPRAGGGSGGS--GSSGGLG 1136
Query: 107 PQCSPAGPEGPARGPKVSFSCRGAASGPAPGP-----GPAEEAGSE--EAGPAGEP 155
P P P G G V+ R +SG P P A +G AGP EP
Sbjct: 1137 P---PGRPYGAIPGQHVTLP-RKTSSGSLPPPLSLFGARATSSGGPPLTAGPQREP 1188
Score = 37.4 bits (85), Expect = 0.062
Identities = 47/153 (30%), Positives = 55/153 (35%), Gaps = 26/153 (16%)
Query: 713 LFPPP--PPPPQVTSAIAT-------LQQAAAMSFCPQVARPLVGPLAL--GSPR----- 756
L PP PPPPQV T L Q + Q A P G L SP
Sbjct: 1053 LLPPASSPPPPQVPQRRGTPPLTPGRLTQDLKLISASQPALPQDGAQTLRRASPHSSGES 1112
Query: 757 -----LVRRPPPGPAPAAASPGPPPPASPPGAPASPRA--PRTSPYGGLPAAPLAGPALP 809
L R G + +S G PP P GA PR + G LP PL+
Sbjct: 1113 MAAFPLFPRAGGGSGGSGSSGGLGPPGRPYGAIPGQHVTLPRKTSSGSLPP-PLS--LFG 1169
Query: 810 ARRLSRASRPLSASQPSLPHGAPGPAASTRPAS 842
AR S PL+A P P P S P++
Sbjct: 1170 ARATSSGGPPLTAGPQREPGARPEPVRSKLPSN 1202
Score = 35.8 bits (81), Expect = 0.18
Identities = 60/232 (25%), Positives = 70/232 (30%), Gaps = 78/232 (33%)
Query: 6 GGGRPGESPGATPAPG--------------PPPPPPPAPPQQQPPPP----PPPAPPPGP 47
G P SP P P P P PPP P AP P
Sbjct: 838 GSASPASSPSQVDTPSSSSFHIQQLAGFSAPAGLSPLLPSSSSSPPPGACGSPSAPTPSA 897
Query: 48 GPA-----------------------PPQHPPRAEALPPEAADEG----GPRGRL----- 75
G A P P + A P+AA G RG L
Sbjct: 898 GVAATTIAGFGHFHKALGGSLSSSDSPLLTPLQPGARSPQAAQPSPAPPGARGGLGLPEH 957
Query: 76 --------RSRDSSCGRPGTP------GAASTAKGSPNGECGRGEPQCSPAGPEGPARGP 121
RS SS G+ G P G A+ +P + EP AG G A
Sbjct: 958 FLPPPPSSRSPSSSPGQLGQPPGELSLGLATGPLSTPETPPRQPEPPSLVAGASGGA--S 1015
Query: 122 KVSFSCRGAASGPAPGPGPAEEAGSEEAGPAGEPRGSQASFMQRQFGALLQP 173
V F+ RG S P PGP P+ PR S + G+LL P
Sbjct: 1016 PVGFTPRGGLSPPGHSPGP------PRTFPSAPPRASGS------HGSLLLP 1055
Score = 33.9 bits (76), Expect = 0.69
Identities = 21/65 (32%), Positives = 23/65 (35%), Gaps = 2/65 (3%)
Query: 6 GGGRPGESPGATPAPGPPPPPPPAPPQQQPPPPPPPAPPPGPGPAPPQHPPRAEALPPEA 65
G PGE TP P P Q PPPP PP P A + P A+ E
Sbjct: 135 GDASPGED--RTPPGLAAEPERPGASAQPAASPPPPQQPPQPASASCEQPSVDTAIKVEG 192
Query: 66 ADEGG 70
G
Sbjct: 193 GAAAG 197
>gi|116325989 hyperpolarization activated cyclic nucleotide-gated
potassium channel 1 [Homo sapiens]
Length = 890
Score = 999 bits (2584), Expect = 0.0
Identities = 553/909 (60%), Positives = 618/909 (67%), Gaps = 107/909 (11%)
Query: 68 EGGPRGRLRSRDSSCGRPGTPGAAS-TAKGSPNGECGRGEPQCSPAGPEGPARGPKVSFS 126
EGG + S G P AS T G E G P G G V F
Sbjct: 2 EGGGKPNSSSNSRDDGNSVFPAKASATGAGPAAAEKRLGTPP-GGGGAGAKEHGNSVCFK 60
Query: 127 CRGAASGPAPGPGPAEEAGSEEAGPAGEPRGSQASFMQRQFGALLQPGVNKFSLRMFGSQ 186
G G G G E AG E A PR Q FMQRQF ++LQPGVNKFSLRMFGSQ
Sbjct: 61 VDGGGGGGGGGGGGEEPAGGFE--DAEGPR-RQYGFMQRQFTSMLQPGVNKFSLRMFGSQ 117
Query: 187 KAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDETTAPWIV 246
KAVE+EQERVK+AG WIIHPYSDFRFYWD ML+ MVGNL+IIPVGITFF ++TT PWI+
Sbjct: 118 KAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWII 177
Query: 247 FNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDYIFL 306
FNV SDT FL+DL++NFRTG V ED++EIILDP+ IK YL++WFVVDF+SSIPVDYIFL
Sbjct: 178 FNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFL 237
Query: 307 IVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMR 366
IVEKG+DSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAV+R
Sbjct: 238 IVEKGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVR 297
Query: 367 ICNLISMMLLLCHWDGCLQFLVPMLQDFPRNCWVSINGMVNHSWSELYSFALFKAMSHML 426
I NLI MMLLLCHWDGCLQFLVP+LQDFP +CWVS+N MVN SW + YS+ALFKAMSHML
Sbjct: 298 IFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHML 357
Query: 427 CIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQY 486
CIGYG QAP SM+D+W+TMLSMIVGATCYAMF+GHATALIQSLDSSRRQYQEKYKQVEQY
Sbjct: 358 CIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQY 417
Query: 487 MSFHKLPADFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFA 546
MSFHKLPAD RQKIHDYYEHRYQGK+FDE++IL ELN PLREEIVNFNCRKLVA+MPLFA
Sbjct: 418 MSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFA 477
Query: 547 NADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLSDGSY 606
NADPNFVTAML+KL+FEVFQPGDYIIREG +GKKMYFIQHGV V+TK +KEMKL+DGSY
Sbjct: 478 NADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSY 537
Query: 607 FGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKK 666
FGEICLLT+GRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKK
Sbjct: 538 FGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKK 597
Query: 667 NSILLHKVQHDLNSGVFNNQENAIIQEIVKYDREMVQQAELGQRVGLFPPPPPPPQVTSA 726
NSILL K Q DLN+GVFNNQEN I+++IVK+DREMVQ P PQ+T+
Sbjct: 598 NSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQAI----------APINYPQMTTL 647
Query: 727 IATLQQAAAMSFCPQVARPLVGPLALGSPRLVRRPPPGPAPAAASPGP------------ 774
+T S + P+ +L L P+P+ +P P
Sbjct: 648 NSTSSTTTPTSRMRTQSPPVYTATSLSHSNL-----HSPSPSTQTPQPSAILSPCSYTTA 702
Query: 775 ---PPPASPPGAP----ASPRA-------------------PRTSPYGGLPAAPLAGPAL 808
PP SP A ASP A P+T P P G +
Sbjct: 703 VCSPPVQSPLAARTFHYASPTASQLSLMQQQPQQQVQQSQPPQTQPQQPSPQPQTPGSST 762
Query: 809 PAR------------RLSRASRPLSASQPSLPH------GAPGPAASTRPASSSTP---- 846
P L+R RPLSASQPSLPH P P AS P
Sbjct: 763 PKNEVHKSTQALHNTNLTREVRPLSASQPSLPHEVSTLISRPHPTVGESLASIPQPVTAV 822
Query: 847 -----------------------RLGPTPAARAAAPSPDRRDSASPGAAGGL---DPQDS 880
G P R P+P +A P + + DP D+
Sbjct: 823 PGTGLQAGGRSTVPQRVTLFRQMSSGAIPPNRGVPPAPPPPAAALPRESSSVLNTDP-DA 881
Query: 881 ARSRLSSNL 889
+ R +SNL
Sbjct: 882 EKPRFASNL 890
>gi|38327037 hyperpolarization activated cyclic nucleotide-gated
potassium channel 3 [Homo sapiens]
Length = 774
Score = 909 bits (2348), Expect = 0.0
Identities = 498/774 (64%), Positives = 567/774 (73%), Gaps = 51/774 (6%)
Query: 129 GAASGPAPG--------PGPAEEAGSEEAGPAGEPRGSQASFMQRQFGALLQPGVNKFSL 180
GA+ G PG P PA A EP+ +R G LLQP VNKFSL
Sbjct: 10 GASEGATPGLEAVPPVAPPPATAASGPIPKSGPEPK-------RRHLGTLLQPTVNKFSL 62
Query: 181 RMFGSQKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDET 240
R+FGS KAVE EQERVKSAGAWIIHPYSDFRFYWD MLL MVGNLI++PVGITFFK+E
Sbjct: 63 RVFGSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEEN 122
Query: 241 TAPWIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIP 300
+ PWIVFNV+SDTFFL+DLVLNFRTGIV+E+ EI+L P I+ +YLRTWF+VD +SSIP
Sbjct: 123 SPPWIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIP 182
Query: 301 VDYIFLIVE--KGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTY 358
VDYIFL+VE +D+EVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTY
Sbjct: 183 VDYIFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTY 242
Query: 359 DLASAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFPRNCWVSINGMVNHSWSELYSFAL 418
DLASAV+RI NLI MMLLLCHWDGCLQFLVPMLQDFP +CWVSIN MVNHSW YS AL
Sbjct: 243 DLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWGRQYSHAL 302
Query: 419 FKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQE 478
FKAMSHMLCIGYG+QAP M D+WLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQE
Sbjct: 303 FKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQE 362
Query: 479 KYKQVEQYMSFHKLPADFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREEIVNFNCRKL 538
KYKQVEQYMSFHKLPAD RQ+IH+YYEHRYQGKMFDE+SILGEL+ PLREEI+NF CR L
Sbjct: 363 KYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDEESILGELSEPLREEIINFTCRGL 422
Query: 539 VASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKE 598
VA MPLFA+ADP+FVTA+LTKL+FEVFQPGD ++REG++G+KMYFIQHG++SVL +G ++
Sbjct: 423 VAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARD 482
Query: 599 MKLSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAID 658
+L+DGSYFGEICLLTRGRRTASVRADTYCRLYSLSVD+FN VLEE+PMMRRAFETVA+D
Sbjct: 483 TRLTDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMD 542
Query: 659 RLDRIGKKNSILLHKVQHDLNSGVFNNQENAIIQEIVKYDREMVQ---------QAELGQ 709
RL RIGKKNSIL K + + + G + + Q +V++DR+M + A+L
Sbjct: 543 RLLRIGKKNSILQRK-RSEPSPG---SSGGIMEQHLVQHDRDMARGVRGRAPSTGAQLSG 598
Query: 710 RVGLFPP----PPPPPQVTS--AIATLQQAAAMSFCPQVARPLVGPLA---LGSPRLVRR 760
+ L+ P P VTS AIA Q + P L+ A GSP
Sbjct: 599 KPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSAWRSAGSPASPLV 658
Query: 761 PPPGPAPAAASPGPPPPASPPGAPASPRAPRTSPYGGLPAAPLAGPALPARRLSRASRPL 820
P A+ S P PPA A S RA R+ L P P RRL RPL
Sbjct: 659 PVRAGPWASTSRLPAPPARTLHASLS-RAGRSQV--SLLGPP---PGGGGRRLGPRGRPL 712
Query: 821 SASQPSLPHGAPGPAASTRPASSSTPRLGPT-----PAARAAAPSPDRRDSASP 869
SASQPSLP A G + R S S RL P+ P A P P + A+P
Sbjct: 713 SASQPSLPQRATGDGSPGRKGSGS-ERLPPSGLLAKPPRTAQPPRPPVPEPATP 765
Score = 31.6 bits (70), Expect = 3.4
Identities = 15/37 (40%), Positives = 18/37 (48%)
Query: 744 RPLVGPLALGSPRLVRRPPPGPAPAAASPGPPPPASP 780
RP G +P L PP P PA A+ GP P + P
Sbjct: 6 RPAAGASEGATPGLEAVPPVAPPPATAASGPIPKSGP 42
>gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2
[Homo sapiens]
Length = 676
Score = 181 bits (460), Expect = 2e-45
Identities = 131/485 (27%), Positives = 236/485 (48%), Gaps = 40/485 (8%)
Query: 184 GSQKAVER-EQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGN--LIIIPVGITFFKDET 240
GSQ+ +R +++ K A ++ P S+ + W + L + N L+I + E
Sbjct: 122 GSQEPADRGRRKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSEY 181
Query: 241 TAPWIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKY-LRTWFVVDFVSSI 299
W+V + +D +++D+++ RTG + + ++ D ++ + Y T F +D +S +
Sbjct: 182 LMLWLVLDYSADVLYVLDVLVRARTGFL--EQGLMVSDTNRLWQHYKTTTQFKLDVLSLV 239
Query: 300 PVDYIFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYD 359
P D +L V VRF RLL+ SRL + + E T
Sbjct: 240 PTDLAYLKVGTNYPE-----------VRFN------RLLKFSRLFEFFDRTE-----TRT 277
Query: 360 LASAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFPRNCWVSINGMV--NHSWSELYSFA 417
+ RI NL+ +L++ HW+ C+ F + F + WV N + + S Y ++
Sbjct: 278 NYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYS 337
Query: 418 LFKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQ 477
L+ + + IG P + ++ +VG +A +G+ ++I ++++SR ++Q
Sbjct: 338 LYWSTLTLTTIGE-TPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQ 396
Query: 478 EKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQG-KMFDEDSILGELNGPLREEIVNFNCR 536
K ++QYM F K+ D ++ ++++ + K DE +L L L+ EI
Sbjct: 397 AKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHL 456
Query: 537 KLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKG- 595
+ + +F + + + ++ KL+ VF PGDYI ++G IGK+MY I G ++V+
Sbjct: 457 DTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDG 516
Query: 596 -NKEMKLSDGSYFGEICLL------TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMM 648
+ + LSDGSYFGEI +L + RRTA++R+ Y L+ LS D+ E L EYP
Sbjct: 517 VTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEA 576
Query: 649 RRAFE 653
++A E
Sbjct: 577 KKALE 581
>gi|13540549 potassium voltage-gated channel, subfamily H, member 6
isoform 1 [Homo sapiens]
Length = 994
Score = 180 bits (457), Expect = 5e-45
Identities = 128/482 (26%), Positives = 222/482 (46%), Gaps = 55/482 (11%)
Query: 202 WIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFF---KDE--------TTAPWIVFNVV 250
W I YS F+ WD+ +LL ++ + P F +DE T +P V +++
Sbjct: 247 WTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPLTVVDLI 306
Query: 251 SDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDYIFLIVEK 310
D F++D+V+NFRT V N E++ P +I Y + WF++D V++IP D LI
Sbjct: 307 VDIMFVVDIVINFRTTYV-NTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFD--LLIFRT 363
Query: 311 GIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICNL 370
G D T ++ LL+ RL RL+R + + + Y A + +C
Sbjct: 364 GSDET-------------TTLIGLLKTARLLRLVRVARKLDR--YSEYGAAVLFLLMCTF 408
Query: 371 ISMMLLLCHWDGCLQFLV-----PMLQDFPRNCWVSINGMV------------NHSWSEL 413
L+ HW C+ + + P L+ + W+ G+ S +
Sbjct: 409 A----LIAHWLACIWYAIGNVERPYLEH--KIGWLDSLGVQLGKRYNGSDPASGPSVQDK 462
Query: 414 YSFALFKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSR 473
Y AL+ S + +G+G +P + ++ ++ M++G+ YA G+ +A+IQ L S
Sbjct: 463 YVTALYFTFSSLTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGT 522
Query: 474 RQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQ-GKMFDEDSILGELNGPLREEIVN 532
+Y + +V++++ FH++P RQ++ +Y++H + D +++L L+ +I
Sbjct: 523 ARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICL 582
Query: 533 FNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVL 592
R L+ P F+ A + A+ K K PGD ++ G + +YFI G + +L
Sbjct: 583 HLHRALLQHCPAFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEIL 642
Query: 593 TKGNKEMKLSDGSYFGEICLL--TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRR 650
L FGE L G+ +A VRA TYC L+ + + EVL+ YP
Sbjct: 643 RDDVVVAILGKNDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAE 702
Query: 651 AF 652
+F
Sbjct: 703 SF 704
>gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Homo
sapiens]
Length = 694
Score = 180 bits (456), Expect = 6e-45
Identities = 128/476 (26%), Positives = 231/476 (48%), Gaps = 39/476 (8%)
Query: 192 EQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGN--LIIIPVGITFFKDETTAPWIVFNV 249
E+++ K A ++ P S+ + W + L + N L+I + E W+V +
Sbjct: 149 EEKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDY 208
Query: 250 VSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKY-LRTWFVVDFVSSIPVDYIFLIV 308
+D +++D+++ RTG + + ++ D ++ + Y T F +D +S +P D +L V
Sbjct: 209 SADVLYVLDVLVRARTGFL--EQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKV 266
Query: 309 EKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRIC 368
VRF RLL+ SRL + + E T + RI
Sbjct: 267 GTNYPE-----------VRFN------RLLKFSRLFEFFDRTE-----TRTNYPNMFRIG 304
Query: 369 NLISMMLLLCHWDGCLQFLVPMLQDFPRNCWVSINGMV--NHSWSELYSFALFKAMSHML 426
NL+ +L++ HW+ C+ F + F + WV N + + S Y ++L+ + +
Sbjct: 305 NLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLT 364
Query: 427 CIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQY 486
IG P + ++ +VG +A +G+ ++I ++++SR ++Q K ++QY
Sbjct: 365 TIGE-TPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQY 423
Query: 487 MSFHKLPADFRQKIHDYYEHRYQG-KMFDEDSILGELNGPLREEIVNFNCRKLVASMPLF 545
M F K+ D ++ ++++ + K DE +L L L+ EI + + +F
Sbjct: 424 MQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIF 483
Query: 546 ANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKG--NKEMKLSD 603
+ + + ++ KL+ VF PGDYI ++G IGK+MY I G ++V+ + + LSD
Sbjct: 484 QDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSD 543
Query: 604 GSYFGEICLL------TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFE 653
GSYFGEI +L + RRTA++R+ Y L+ LS D+ E L EYP ++A E
Sbjct: 544 GSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALE 599
>gi|27886653 potassium voltage-gated channel, subfamily H, member 7
isoform 1 [Homo sapiens]
Length = 1196
Score = 173 bits (439), Expect = 6e-43
Identities = 126/483 (26%), Positives = 223/483 (46%), Gaps = 56/483 (11%)
Query: 203 IIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDE-----------TTAPWIVFNVVS 251
I+H YS F+ WD+ +LL ++ I P F ++ + +P V +++
Sbjct: 400 ILH-YSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIV 458
Query: 252 DTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDYIFLIVEKG 311
D F++D+++NFRT V N E++ DP KI Y + WF++D V++IP D LI G
Sbjct: 459 DIMFIIDILINFRTTYV-NQNEEVVSDPAKIAIHYFKGWFLIDMVAAIPFD--LLIFGSG 515
Query: 312 IDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICNLI 371
D T ++ LL+ RL RL+R + + + Y A ++ +C
Sbjct: 516 SDET-------------TTLIGLLKTARLLRLVRVARKLDR--YSEYGAAVLMLLMC--- 557
Query: 372 SMMLLLCHWDGCLQFLV-----PMLQDFPRNCWVSINGMV------------NHSWSELY 414
+ L+ HW C+ + + P L D + W+ G S + Y
Sbjct: 558 -IFALIAHWLACIWYAIGNVERPYLTD--KIGWLDSLGQQIGKRYNDSDSSSGPSIKDKY 614
Query: 415 SFALFKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRR 474
AL+ S + +G+G +P + ++ ++ M++G+ YA G+ +A+IQ L S
Sbjct: 615 VTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTA 674
Query: 475 QYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRY-QGKMFDEDSILGELNGPLREEIVNF 533
+Y + +V++++ FH++P RQ++ +Y++H + D + +L L+ +I
Sbjct: 675 RYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLH 734
Query: 534 NCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLT 593
+ L+ + F A + A+ K K PGD ++ G + +YF+ G + +L
Sbjct: 735 LNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILK 794
Query: 594 KGNKEMKLSDGSYFGEICLL--TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRA 651
L FGE+ L G+ A VRA TYC L+ + ++ EVL+ YP
Sbjct: 795 DDIVVAILGKNDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQREDLLEVLDMYPEFSDH 854
Query: 652 FET 654
F T
Sbjct: 855 FLT 857
>gi|26051273 voltage-gated potassium channel, subfamily H, member 2
isoform c [Homo sapiens]
Length = 819
Score = 173 bits (438), Expect = 7e-43
Identities = 161/659 (24%), Positives = 271/659 (41%), Gaps = 103/659 (15%)
Query: 202 WIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDETTA------------PWIVFNV 249
W I YS F+ WD+ +LL ++ + P F ET P V ++
Sbjct: 58 WTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDL 117
Query: 250 VSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDYIFLIVE 309
+ D F++D+++NFRT V N E++ P +I Y + WF++D V++IP D +
Sbjct: 118 IVDIMFIVDILINFRTTYV-NANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIF--- 173
Query: 310 KGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICN 369
G SE +L RLLRL R+ R + ++ E Y A + +C
Sbjct: 174 -GSGSE-----------ELIGLLKTARLLRLVRVARKLDRYSE-----YGAAVLFLLMCT 216
Query: 370 LISMMLLLCHWDGCLQFLVPMLQD---FPRNCWV-----------SINGMVNHSWSELYS 415
L+ HW C+ + + ++ R W+ + +G+ S + Y
Sbjct: 217 FA----LIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYV 272
Query: 416 FALFKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQ 475
AL+ S + +G+G +P + ++ ++ M++G+ YA G+ +A+IQ L S +
Sbjct: 273 TALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTAR 332
Query: 476 YQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQ-GKMFDEDSILGELNGPLREEIVNFN 534
Y + +V +++ FH++P RQ++ +Y++H + D +++L L+ +I
Sbjct: 333 YHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHL 392
Query: 535 CRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTK 594
R L+ F A + A+ K K PGD ++ G + +YFI G + +L
Sbjct: 393 NRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRG 452
Query: 595 GNKEMKLSDGSYFGE-ICLLTR-GRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAF 652
L FGE + L R G+ VRA TYC L+ + D+ EVL+ YP F
Sbjct: 453 DVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHF 512
Query: 653 ETVAIDRLDRIGKKNSILLHKVQHDLNSGVFNNQENAIIQEIVKYDREMVQQAELGQRVG 712
+ +++ + N I +L G F+ Q + + D++ Q E+
Sbjct: 513 WS-SLEITFNLRDTNMIPGSPGSTELEGG-FSRQRKRKLSFRRRTDKDTEQPGEVS---- 566
Query: 713 LFPPPPPPPQVTSAIATLQQAAAMSFCPQVARPLVGPLALGSPRLVRRPPPGPAPAAASP 772
+GP G+ R P GP + S
Sbjct: 567 ---------------------------------ALGPGRAGAGPSSRGRPGGPWGESPSS 593
Query: 773 GPPPPASP----PGAPASP--RAPRTSPYGGLPAAPLAGPAL--PARRLSRASRPLSAS 823
GP P S PG +SP P +SP P P G L + S PLS +
Sbjct: 594 GPSSPESSEDEGPGRSSSPLRLVPFSSPRP--PGEPPGGEPLMEDCEKSSDTCNPLSGA 650
Score = 31.2 bits (69), Expect = 4.5
Identities = 20/75 (26%), Positives = 25/75 (33%), Gaps = 13/75 (17%)
Query: 85 PGTPGAASTAKGSPNGECGRGEPQCSPAGPEGPARGPKVSFSCRGAASGPAPGPGPAEEA 144
PG GA +++G P G G P P+ PE GP P
Sbjct: 570 PGRAGAGPSSRGRPGGPWGE-SPSSGPSSPES------------SEDEGPGRSSSPLRLV 616
Query: 145 GSEEAGPAGEPRGSQ 159
P GEP G +
Sbjct: 617 PFSSPRPPGEPPGGE 631
Score = 30.4 bits (67), Expect = 7.6
Identities = 29/109 (26%), Positives = 39/109 (35%), Gaps = 24/109 (22%)
Query: 763 PGPAPAAASPGPPPPASPPGAPASPRAPRTSPYGGLPAAPLAGPALPARRLSRASRPLSA 822
P A +PGP P ++ P P SP P L LS+ S+ ++
Sbjct: 735 PPAYSAVTTPGPGPTSTSPLLPVSPL-----------------PTLTLDSLSQVSQFMAC 777
Query: 823 SQPSLPHGAPGPAASTRPASSSTPRLGPTPAARAAAPSPDRRDSASPGA 871
+ LP GAP P T RL A P R + PG+
Sbjct: 778 EE--LPPGAP-----ELPQEGPTRRLSLPGQLGALTSQPLHRHGSDPGS 819
Score = 30.0 bits (66), Expect = 10.0
Identities = 19/58 (32%), Positives = 24/58 (41%), Gaps = 9/58 (15%)
Query: 8 GRPGESPGATPAPGPPPPPPPAPPQQQPPPPPPPAPP----PGPGPAPPQHPPRAEAL 61
GRPG G +P+ G P +P + P + P P P PP PP E L
Sbjct: 581 GRPGGPWGESPSSG-----PSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPL 633
>gi|4557729 voltage-gated potassium channel, subfamily H, member 2
isoform a [Homo sapiens]
Length = 1159
Score = 173 bits (438), Expect = 7e-43
Identities = 161/659 (24%), Positives = 271/659 (41%), Gaps = 103/659 (15%)
Query: 202 WIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDETTA------------PWIVFNV 249
W I YS F+ WD+ +LL ++ + P F ET P V ++
Sbjct: 398 WTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDL 457
Query: 250 VSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDYIFLIVE 309
+ D F++D+++NFRT V N E++ P +I Y + WF++D V++IP D +
Sbjct: 458 IVDIMFIVDILINFRTTYV-NANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIF--- 513
Query: 310 KGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICN 369
G SE +L RLLRL R+ R + ++ E Y A + +C
Sbjct: 514 -GSGSE-----------ELIGLLKTARLLRLVRVARKLDRYSE-----YGAAVLFLLMCT 556
Query: 370 LISMMLLLCHWDGCLQFLVPMLQD---FPRNCWV-----------SINGMVNHSWSELYS 415
L+ HW C+ + + ++ R W+ + +G+ S + Y
Sbjct: 557 FA----LIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYV 612
Query: 416 FALFKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQ 475
AL+ S + +G+G +P + ++ ++ M++G+ YA G+ +A+IQ L S +
Sbjct: 613 TALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTAR 672
Query: 476 YQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQ-GKMFDEDSILGELNGPLREEIVNFN 534
Y + +V +++ FH++P RQ++ +Y++H + D +++L L+ +I
Sbjct: 673 YHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHL 732
Query: 535 CRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTK 594
R L+ F A + A+ K K PGD ++ G + +YFI G + +L
Sbjct: 733 NRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRG 792
Query: 595 GNKEMKLSDGSYFGE-ICLLTR-GRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAF 652
L FGE + L R G+ VRA TYC L+ + D+ EVL+ YP F
Sbjct: 793 DVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHF 852
Query: 653 ETVAIDRLDRIGKKNSILLHKVQHDLNSGVFNNQENAIIQEIVKYDREMVQQAELGQRVG 712
+ +++ + N I +L G F+ Q + + D++ Q E+
Sbjct: 853 WS-SLEITFNLRDTNMIPGSPGSTELEGG-FSRQRKRKLSFRRRTDKDTEQPGEVS---- 906
Query: 713 LFPPPPPPPQVTSAIATLQQAAAMSFCPQVARPLVGPLALGSPRLVRRPPPGPAPAAASP 772
+GP G+ R P GP + S
Sbjct: 907 ---------------------------------ALGPGRAGAGPSSRGRPGGPWGESPSS 933
Query: 773 GPPPPASP----PGAPASP--RAPRTSPYGGLPAAPLAGPAL--PARRLSRASRPLSAS 823
GP P S PG +SP P +SP P P G L + S PLS +
Sbjct: 934 GPSSPESSEDEGPGRSSSPLRLVPFSSPRP--PGEPPGGEPLMEDCEKSSDTCNPLSGA 990
Score = 31.2 bits (69), Expect = 4.5
Identities = 20/75 (26%), Positives = 25/75 (33%), Gaps = 13/75 (17%)
Query: 85 PGTPGAASTAKGSPNGECGRGEPQCSPAGPEGPARGPKVSFSCRGAASGPAPGPGPAEEA 144
PG GA +++G P G G P P+ PE GP P
Sbjct: 910 PGRAGAGPSSRGRPGGPWGE-SPSSGPSSPES------------SEDEGPGRSSSPLRLV 956
Query: 145 GSEEAGPAGEPRGSQ 159
P GEP G +
Sbjct: 957 PFSSPRPPGEPPGGE 971
Score = 30.4 bits (67), Expect = 7.6
Identities = 29/109 (26%), Positives = 39/109 (35%), Gaps = 24/109 (22%)
Query: 763 PGPAPAAASPGPPPPASPPGAPASPRAPRTSPYGGLPAAPLAGPALPARRLSRASRPLSA 822
P A +PGP P ++ P P SP P L LS+ S+ ++
Sbjct: 1075 PPAYSAVTTPGPGPTSTSPLLPVSPL-----------------PTLTLDSLSQVSQFMAC 1117
Query: 823 SQPSLPHGAPGPAASTRPASSSTPRLGPTPAARAAAPSPDRRDSASPGA 871
+ LP GAP P T RL A P R + PG+
Sbjct: 1118 EE--LPPGAP-----ELPQEGPTRRLSLPGQLGALTSQPLHRHGSDPGS 1159
Score = 30.0 bits (66), Expect = 10.0
Identities = 19/58 (32%), Positives = 24/58 (41%), Gaps = 9/58 (15%)
Query: 8 GRPGESPGATPAPGPPPPPPPAPPQQQPPPPPPPAPP----PGPGPAPPQHPPRAEAL 61
GRPG G +P+ G P +P + P + P P P PP PP E L
Sbjct: 921 GRPGGPWGESPSSG-----PSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPL 973
>gi|4504831 potassium voltage-gated channel, subfamily H, member 1
isoform 2 [Homo sapiens]
Length = 962
Score = 173 bits (438), Expect = 7e-43
Identities = 139/566 (24%), Positives = 241/566 (42%), Gaps = 76/566 (13%)
Query: 184 GSQKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDETTAP 243
GS + +QE K+ I+H Y F+ WD+ +L+ I++P ++F +
Sbjct: 191 GSDILPQYKQEAPKTPPHIILH-YCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVA 249
Query: 244 WIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDY 303
W+V + + D FL+D+VLNF T V E+I DP+ I+ YL+TWFV+D +S +P D
Sbjct: 250 WLVVDSIVDVIFLVDIVLNFHTTFVGPAG-EVISDPKLIRMNYLKTWFVIDLLSCLPYDV 308
Query: 304 I--FLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLA 361
I F V++GI S L ++RLLRL R+ R + + E Y A
Sbjct: 309 INAFENVDEGISS-------------LFSSLKVVRLLRLGRVARKLDHYIE-----YGAA 350
Query: 362 SAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFPR-------NCWV-----------SIN 403
V+ +C + L HW C+ + + + F N W+ N
Sbjct: 351 VLVLLVC----VFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFN 406
Query: 404 GMVNHSW------SELYSFALFKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAM 457
G + W + +Y +L+ M+ + +G+G AP + + + M++G+ YA
Sbjct: 407 GSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYAT 466
Query: 458 FIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRY-QGKMFDED 516
G+ T + Q + ++ +Y E V ++ +++P +++ DY + + D +
Sbjct: 467 IFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTE 526
Query: 517 SILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGT 576
+L +R +I RK+ P F A + A+ + + PGD I G
Sbjct: 527 KVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGE 586
Query: 577 IGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGEICL--LTRGRRTASVRADTYCRLYSLS 634
+ F+ G + V+ L G FG++ T + A+VRA TYC L+ +
Sbjct: 587 SVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIK 646
Query: 635 VDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLHKVQHDLNSGVFNNQENAIIQEI 694
D +VLE Y +F +N IL +N ++ + ++I
Sbjct: 647 RDALQKVLEFYTAFSHSF------------SRNLIL-----------TYNLRKRIVFRKI 683
Query: 695 VKYDREMVQQAELGQRVGLFPPPPPP 720
RE ++ + L PP P
Sbjct: 684 SDVKREEEERMKRKNEAPLILPPDHP 709
>gi|6912446 potassium voltage-gated channel, subfamily H, member 4
[Homo sapiens]
Length = 1017
Score = 169 bits (429), Expect = 8e-42
Identities = 193/803 (24%), Positives = 322/803 (40%), Gaps = 126/803 (15%)
Query: 125 FSCRGAASGPAPGPGPAEEAGSEEAGPAGEPRGSQASFM--QRQFGALLQPGVNKFSLRM 182
FS + +PG GP G + RG+ F +R+ +L F R
Sbjct: 128 FSFKDITQSGSPGLGPQGGRGDSNHENSLGRRGATWKFRSARRRSRTVLHRLTGHFGRRG 187
Query: 183 FGSQKAVEREQE--------RVKSAGA---WIIHPYSDFRFYWDFTMLLFMVGNLIIIPV 231
G KA E +V S G ++H YS + WD +LL + +P
Sbjct: 188 QGGMKANNNVFEPKPSVPEYKVASVGGSRCLLLH-YSVSKAIWDGLILLATFYVAVTVPY 246
Query: 232 GITFFKDE----TTAPWIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYL 287
+ F D+ T+ +V ++ + F++D++LNFRT V + ++I P I YL
Sbjct: 247 NVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQSG-QVISAPRSIGLHYL 305
Query: 288 RTWFVVDFVSSIPVDYIFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYI 347
TWF +D ++++P D +++ + T ++ LL+ +RL RL+R +
Sbjct: 306 ATWFFIDLIAALPFDLLYIFN-----------------ITVTSLVHLLKTVRLLRLLRLL 348
Query: 348 HQWEEIFHMTYDLASAVMRICNLISMMLLLCHWDGCLQFLV---------PMLQDFPRNC 398
+ E Y SAV+ + L+S+ LL HW C+ +++ P+L D
Sbjct: 349 QKLER-----YSQCSAVV-LTLLMSVFALLAHWMACIWYVIGRREMEANDPLLWDIG--- 399
Query: 399 WVS----------INGMVNH-SWSELYSFALFKAMSHMLCIGYGRQAPESMTDIWLTMLS 447
W+ +NG V S Y AL+ +S + +G+G + + ++ +
Sbjct: 400 WLHELGKRLEVPYVNGSVGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICT 459
Query: 448 MIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHR 507
M++GA +A+ G+ TA+IQ + S R Y + K ++ ++ H+LP +Q++ +Y++
Sbjct: 460 MLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTT 519
Query: 508 YQ-GKMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQ 566
+ D + +L + LR +I + + + +PLF A + A+ +K
Sbjct: 520 WAVNSGIDANELLRDFPDELRADIA-MHLNREILQLPLFGAASRGCLRALSLHIKTSFCA 578
Query: 567 PGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFG----------------EI 610
PG+Y++R G + Y++ G + VL L G G
Sbjct: 579 PGEYLLRRGDALQAHYYVCSGSLEVLRDNMVLAILGKGDLIGADIPEPGQEPGLGADPNF 638
Query: 611 CLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSIL 670
L T +A V+A TYC L LS EVL YP AF R G +
Sbjct: 639 VLKT----SADVKALTYCGLQQLSSRGLAEVLRLYPEYGAAF---------RAGLPRDLT 685
Query: 671 LHKVQHDLNSGVFNNQENAIIQEI------VKYDREM--VQQAELGQRVGLFPPPPPP-- 720
+ Q SG+ + + + D+ + + +AE G G P P P
Sbjct: 686 FNLRQGSDTSGLSRFSRSPRLSQPRSESLGSSSDKTLPSITEAESGAEPGGGPRPRRPLL 745
Query: 721 -PQVTSA-----IATLQQAAAMSFCPQVARPLVGPLALGSPRLVRR----PPPGPAPAAA 770
P ++ A + +L F V+ P + P SP L + P GP +A
Sbjct: 746 LPNLSPARPRGSLVSLLGEELPPFSALVSSPSLSPSL--SPALAGQGHSASPHGPPRCSA 803
Query: 771 SPGPP----PPASPPGAP-ASPRAPRTSPYGGLPAAPLAGPALPARRLSRASRPLSASQP 825
+ PP PP G P SPR G A P+ R RP S + P
Sbjct: 804 AWKPPQLLIPPLGTFGPPDLSPRIVDGIEDSGSTA---EAPSFRFSRRPELPRPRSQAPP 860
Query: 826 SLPHGAPGPAASTRPASSSTPRL 848
+ +P A+ RL
Sbjct: 861 TGTRPSPELASEAEEVKEKVCRL 883
Score = 33.1 bits (74), Expect = 1.2
Identities = 36/122 (29%), Positives = 46/122 (37%), Gaps = 16/122 (13%)
Query: 741 QVARPLVGPLALGSPRLVRRPPPGPAPAAASPGPPPPASPPGAPASPRAPRTSPYGGLPA 800
Q++R L + L RL PP PA +A +P PP P P P SP P
Sbjct: 896 QLSRELRHIMGLLQARL--GPPGHPAGSAWTPDPPCPQLRP--------PCLSPCASRPP 945
Query: 801 APLAGPALPARRLSRASRPLSASQPSLPHGAPGPAASTRPASSSTPR-LGPTPAARAAAP 859
P+L L+ P S S P S P LGP+P A+ P
Sbjct: 946 -----PSLQDTTLAEVHCPASVGTMETGTALLDLRPSILPPYPSEPDPLGPSPVPEASPP 1000
Query: 860 SP 861
+P
Sbjct: 1001 TP 1002
Score = 30.8 bits (68), Expect = 5.8
Identities = 36/121 (29%), Positives = 49/121 (40%), Gaps = 27/121 (22%)
Query: 684 NNQENAIIQEIVKYDREM-----VQQAELGQ----RVGLFPPPPPPPQVTSAIAT----- 729
N + + + QE+ + RE+ + QA LG + P PP PQ+ +
Sbjct: 884 NQEISRLNQEVSQLSRELRHIMGLLQARLGPPGHPAGSAWTPDPPCPQLRPPCLSPCASR 943
Query: 730 ----LQQAA-AMSFCPQVARPLVGPLALGSPRLVRRP---PPGPA-PAAASPGPPPPASP 780
LQ A CP VG + G+ L RP PP P+ P P P P ASP
Sbjct: 944 PPPSLQDTTLAEVHCPAS----VGTMETGTALLDLRPSILPPYPSEPDPLGPSPVPEASP 999
Query: 781 P 781
P
Sbjct: 1000 P 1000
>gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]
Length = 575
Score = 169 bits (427), Expect = 1e-41
Identities = 122/480 (25%), Positives = 229/480 (47%), Gaps = 45/480 (9%)
Query: 203 IIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITF--FKDETTAPWIVFNVVSDTFFLMDLV 260
++ P D+ ++W TM+ ++ NLII+ F + W+V + SD +L+D+V
Sbjct: 26 VLDPSGDYYYWWLNTMVFPVMYNLIILVCRACFPDLQHGYLVAWLVLDYTSDLLYLLDMV 85
Query: 261 LNFRTGIVIEDNTEIILDPEKIKKKYLRTW-FVVDFVSSIPVDYIFLIVEKGIDSEVYKT 319
+ F TG + + +++D +I +Y+RTW F +D S +P D +++
Sbjct: 86 VRFHTGFL--EQGILVVDKGRISSRYVRTWSFFLDLASLMPTDVVYV------------- 130
Query: 320 ARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICNLISMMLLLCH 379
R+ T L L R LR RL + E T RI L+ + ++ H
Sbjct: 131 ----RLGPHTPTLRLNRFLRAPRLFEAFDRTE-----TRTAYPNAFRIAKLMLYIFVVIH 181
Query: 380 WDGCLQFLVPMLQDFPRNCWVSIN----GMVNHSWSELYSFALFKAMSHMLCIGYGRQAP 435
W+ CL F + F R+ WV + G LYSF S ++ G P
Sbjct: 182 WNSCLYFALSRYLGFGRDAWVYPDPAQPGFERLRRQYLYSFYF----STLILTTVGDTPP 237
Query: 436 ESMTDIWLTMLS-MIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPA 494
+ + +L M+ ++ +A +G +++I +++++ + + V++YM +
Sbjct: 238 PAREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNR 297
Query: 495 DFRQKIHDYYEH-RYQGKMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFV 553
+++ D+Y+H + KM +E +IL L LR E+ ++ + +F N + + +
Sbjct: 298 KLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLL 357
Query: 554 TAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKG--NKEMKLSDGSYFGEIC 611
++ KL+ + + PG+Y+ R+G IG++MY I+ G ++V+ + L G YFGEI
Sbjct: 358 EELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVLGAGLYFGEIS 417
Query: 612 L------LTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGK 665
+ ++ RRTA++++ Y L+ LS ++ EVL EYP + E + L ++ K
Sbjct: 418 IINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQAQTIMEEKGREILLKMNK 477
>gi|22024390 potassium voltage-gated channel, subfamily H, member 5
isoform 1 [Homo sapiens]
Length = 988
Score = 168 bits (425), Expect = 2e-41
Identities = 130/497 (26%), Positives = 220/497 (44%), Gaps = 52/497 (10%)
Query: 184 GSQKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDETTAP 243
GS + +QE K+ I+H Y F+ WD+ +L+ I++P ++F +
Sbjct: 188 GSDILPQYKQEAPKTPPHIILH-YCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIA 246
Query: 244 WIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDY 303
W+V + V D FL+D+VLNF T V E+I DP+ I+ YL+TWFV+D +S +P D
Sbjct: 247 WLVLDSVVDVIFLVDIVLNFHTTFV-GPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDI 305
Query: 304 I--FLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLA 361
I F V++GI S L ++RLLRL R+ R + + E Y A
Sbjct: 306 INAFENVDEGISS-------------LFSSLKVVRLLRLGRVARKLDHYLE-----YGAA 347
Query: 362 SAVMRICNLISMMLLLCHWDGCLQFLV-------PMLQDFPRNCW-----VSINGMVNHS 409
V+ +C + L+ HW C+ + + + + W +SI ++
Sbjct: 348 VLVLLVC----VFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYN 403
Query: 410 WS-----------ELYSFALFKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMF 458
S LY +L+ M+ + IG+G AP + + ++ M+VG+ YA
Sbjct: 404 TSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATI 463
Query: 459 IGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRY-QGKMFDEDS 517
G+ T + Q + ++ +Y E V ++ +++P +++ DY + K D +
Sbjct: 464 FGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEK 523
Query: 518 ILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTI 577
+L +R +I RK+ P F A + A+ + + PGD I G
Sbjct: 524 VLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGES 583
Query: 578 GKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGEICL--LTRGRRTASVRADTYCRLYSLSV 635
+ F+ G + V+ L G FG+I T A+VRA TYC L+ +
Sbjct: 584 VDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKR 643
Query: 636 DNFNEVLEEYPMMRRAF 652
+ +VL+ Y +F
Sbjct: 644 EALLKVLDFYTAFANSF 660
>gi|27886648 potassium voltage-gated channel, subfamily H, member 5
isoform 2 [Homo sapiens]
Length = 624
Score = 168 bits (425), Expect = 2e-41
Identities = 130/497 (26%), Positives = 220/497 (44%), Gaps = 52/497 (10%)
Query: 184 GSQKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDETTAP 243
GS + +QE K+ I+H Y F+ WD+ +L+ I++P ++F +
Sbjct: 130 GSDILPQYKQEAPKTPPHIILH-YCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIA 188
Query: 244 WIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDY 303
W+V + V D FL+D+VLNF T V E+I DP+ I+ YL+TWFV+D +S +P D
Sbjct: 189 WLVLDSVVDVIFLVDIVLNFHTTFV-GPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDI 247
Query: 304 I--FLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLA 361
I F V++GI S L ++RLLRL R+ R + + E Y A
Sbjct: 248 INAFENVDEGISS-------------LFSSLKVVRLLRLGRVARKLDHYLE-----YGAA 289
Query: 362 SAVMRICNLISMMLLLCHWDGCLQFLV-------PMLQDFPRNCW-----VSINGMVNHS 409
V+ +C + L+ HW C+ + + + + W +SI ++
Sbjct: 290 VLVLLVC----VFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYN 345
Query: 410 WS-----------ELYSFALFKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMF 458
S LY +L+ M+ + IG+G AP + + ++ M+VG+ YA
Sbjct: 346 TSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATI 405
Query: 459 IGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRY-QGKMFDEDS 517
G+ T + Q + ++ +Y E V ++ +++P +++ DY + K D +
Sbjct: 406 FGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEK 465
Query: 518 ILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTI 577
+L +R +I RK+ P F A + A+ + + PGD I G
Sbjct: 466 VLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGES 525
Query: 578 GKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGEICL--LTRGRRTASVRADTYCRLYSLSV 635
+ F+ G + V+ L G FG+I T A+VRA TYC L+ +
Sbjct: 526 VDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKR 585
Query: 636 DNFNEVLEEYPMMRRAF 652
+ +VL+ Y +F
Sbjct: 586 EALLKVLDFYTAFANSF 602
>gi|27886651 potassium voltage-gated channel, subfamily H, member 6
isoform 2 [Homo sapiens]
Length = 905
Score = 168 bits (425), Expect = 2e-41
Identities = 177/727 (24%), Positives = 292/727 (40%), Gaps = 127/727 (17%)
Query: 202 WIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFF---KDE--------TTAPWIVFNVV 250
W I YS F+ WD+ +LL ++ + P F +DE T +P V +++
Sbjct: 247 WTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPLTVVDLI 306
Query: 251 SDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDYIFLIVEK 310
D F++D+V+NFRT V N E++ P +I Y + WF++D V++IP D LI
Sbjct: 307 VDIMFVVDIVINFRTTYV-NTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFD--LLIFRT 363
Query: 311 GIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICNL 370
G D T ++ LL+ RL RL+R + + + Y A + +C
Sbjct: 364 GSDET-------------TTLIGLLKTARLLRLVRVARKLDR--YSEYGAAVLFLLMCTF 408
Query: 371 ISMMLLLCHWDGCLQFLVPMLQDFPRNCWVSINGMVNHSWSELYSFALFKAMSHMLCIGY 430
L+ HW C+ L +G+
Sbjct: 409 A----LIAHWLACICSLTS--------------------------------------VGF 426
Query: 431 GRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFH 490
G +P + ++ ++ M++G+ YA G+ +A+IQ L S +Y + +V++++ FH
Sbjct: 427 GNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFH 486
Query: 491 KLPADFRQKIHDYYEHRYQ-GKMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANAD 549
++P RQ++ +Y++H + D +++L L+ +I R L+ P F+ A
Sbjct: 487 QIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAG 546
Query: 550 PNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGE 609
+ A+ K K PGD ++ G + +YFI G + +L L FGE
Sbjct: 547 KGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGE 606
Query: 610 ICLL--TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFET---VAIDRLDRIG 664
L G+ +A VRA TYC L+ + + EVL+ YP +F + V + D G
Sbjct: 607 PVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFNLRDAAG 666
Query: 665 KKNSILLHKVQHDLNSGVF--NNQENAI----IQEIVKYDREMVQQAELGQRVGLFPPPP 718
+S + G F +NQ +A I + E++Q E+ R P
Sbjct: 667 GLHSSPRQAPGSQDHQGFFLSDNQSDAAPPLSISDASGLWPELLQ--EMPPRHSPQSPQE 724
Query: 719 PPP----QVTSAIATLQ------QAAAMSFCPQVARPLVGPLALGSPRLVRRPPPGP--- 765
P ++ S + LQ ++ S ++ + L P+ G + P
Sbjct: 725 DPDCWPLKLGSRLEQLQAQMNRLESRVSSDLSRILQLLQKPMPQGHASYILEAPASNDLA 784
Query: 766 -APAAASPGPPPPASPPG--APASPRAPRTSPYGGL----PAAPLAGPALPARRLSRASR 818
P A+ P P P G PA +T YG L P + P +P ++
Sbjct: 785 LVPIASETTSPGPRLPQGFLPPA-----QTPSYGDLDDCSPKHRNSSPRMPHLAVATDKT 839
Query: 819 PLSASQPSLPHGAPGPAAS-----------TRPASSSTP-RLGPTPAARAAAPSPDRRDS 866
+S+ P G P AS P SS P LG P +R
Sbjct: 840 LAPSSEQEQPEGLWPPLASPLHPLEVQGLICGPCFSSLPEHLGSVP-----KQLDFQRHG 894
Query: 867 ASPGAAG 873
+ PG AG
Sbjct: 895 SDPGFAG 901
>gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]
Length = 664
Score = 167 bits (423), Expect = 4e-41
Identities = 124/467 (26%), Positives = 223/467 (47%), Gaps = 41/467 (8%)
Query: 202 WIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITF--FKDETTAPWIVFNVVSDTFFLMDL 259
+++ P D+ + W F + + ++ N ++ F + W+V + VSD ++ DL
Sbjct: 131 FVLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIADL 190
Query: 260 VLNFRTGIVIEDNTEIILDPEKIKKKYLRTW-FVVDFVSSIPVDYIFLIVEKGIDSEVYK 318
+ RTG + + ++ D +K++ Y+ T F +D S IP D I+ V+ I S
Sbjct: 191 FIRLRTGFL--EQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVD--IHSPE-- 244
Query: 319 TARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICNLISMMLLLC 378
VRF RLL +R+ + + E T + RI NL+ +L++
Sbjct: 245 -------VRFN------RLLHFARMFEFFDRTE-----TRTNYPNIFRISNLVLYILVII 286
Query: 379 HWDGCLQFLVPMLQDFPRNCWVSINGMVNHSWSEL---YSFALFKAMSHMLCIGYGRQAP 435
HW+ C+ + + F + WV N + + + L Y + L+ + + IG P
Sbjct: 287 HWNACIYYAISKSIGFGVDTWVYPN-ITDPEYGYLAREYIYCLYWSTLTLTTIGE-TPPP 344
Query: 436 ESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPAD 495
+ + ++G +A +G+ ++I +++++R ++Q K V+ YM F K+
Sbjct: 345 VKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKG 404
Query: 496 FRQKIHDYYEHRYQGKM-FDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVT 554
K+ ++++ + K DE IL L LR EI + + +F + + +
Sbjct: 405 MEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLV 464
Query: 555 AMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKG--NKEMKLSDGSYFGEICL 612
++ KL+ +VF PGDYI R+G IGK+MY I+ G ++V+ + LS GS FGEI +
Sbjct: 465 ELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISI 524
Query: 613 LT------RGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFE 653
L RRTA++R+ Y L+ LS D+ E + EYP ++ E
Sbjct: 525 LNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPDAKKVLE 571
>gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1
[Homo sapiens]
Length = 759
Score = 166 bits (419), Expect = 1e-40
Identities = 120/481 (24%), Positives = 233/481 (48%), Gaps = 39/481 (8%)
Query: 186 QKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITF--FKDETTAP 243
+K+ ++++E K +I P + + W F + L ++ N ++ F + +
Sbjct: 211 EKSKDKKEEEKKEVV--VIDPSGNTYYNWLFCITLPVMYNWTMVIARACFDELQSDYLEY 268
Query: 244 WIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDY 303
W++ + VSD +L+D+ + RTG +E + + + I K F +D +S IP D
Sbjct: 269 WLILDYVSDIVYLIDMFVRTRTGY-LEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDL 327
Query: 304 IFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASA 363
++ +K +R L RLLR SR+ + + E T
Sbjct: 328 LY-----------FKLGWNYPEIR------LNRLLRFSRMFEFFQRTE-----TRTNYPN 365
Query: 364 VMRICNLISMMLLLCHWDGCLQFLVPMLQDFPRNCWV--SINGMVNHSWSELYSFALFKA 421
+ RI NL+ ++++ HW+ C+ + + F + WV IN + Y ++L+ +
Sbjct: 366 IFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWS 425
Query: 422 MSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYK 481
+ IG P ++ ++ ++G +A +G+ ++I +++++R ++Q +
Sbjct: 426 TLTLTTIGE-TPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARID 484
Query: 482 QVEQYMSFHKLPADFRQKIHDYYEHRYQGKM-FDEDSILGELNGPLREEIVNFNCRKLVA 540
++QYM F + D +++ ++++ + K DE +L L LR EI +
Sbjct: 485 AIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLK 544
Query: 541 SMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKG--NKE 598
+ +FA+ + + ++ KL+ +V+ PGDYI ++G IG++MY I+ G ++V+ +
Sbjct: 545 KVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQF 604
Query: 599 MKLSDGSYFGEICLL------TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAF 652
+ LSDGSYFGEI +L RRTA++++ Y L+ LS D+ E L EYP +
Sbjct: 605 VVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTML 664
Query: 653 E 653
E
Sbjct: 665 E 665
>gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [Homo
sapiens]
Length = 690
Score = 166 bits (419), Expect = 1e-40
Identities = 120/481 (24%), Positives = 233/481 (48%), Gaps = 39/481 (8%)
Query: 186 QKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITF--FKDETTAP 243
+K+ ++++E K +I P + + W F + L ++ N ++ F + +
Sbjct: 142 EKSKDKKEEEKKEVV--VIDPSGNTYYNWLFCITLPVMYNWTMVIARACFDELQSDYLEY 199
Query: 244 WIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDY 303
W++ + VSD +L+D+ + RTG +E + + + I K F +D +S IP D
Sbjct: 200 WLILDYVSDIVYLIDMFVRTRTGY-LEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDL 258
Query: 304 IFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASA 363
++ +K +R L RLLR SR+ + + E T
Sbjct: 259 LY-----------FKLGWNYPEIR------LNRLLRFSRMFEFFQRTE-----TRTNYPN 296
Query: 364 VMRICNLISMMLLLCHWDGCLQFLVPMLQDFPRNCWV--SINGMVNHSWSELYSFALFKA 421
+ RI NL+ ++++ HW+ C+ + + F + WV IN + Y ++L+ +
Sbjct: 297 IFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWS 356
Query: 422 MSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYK 481
+ IG P ++ ++ ++G +A +G+ ++I +++++R ++Q +
Sbjct: 357 TLTLTTIGE-TPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARID 415
Query: 482 QVEQYMSFHKLPADFRQKIHDYYEHRYQGKM-FDEDSILGELNGPLREEIVNFNCRKLVA 540
++QYM F + D +++ ++++ + K DE +L L LR EI +
Sbjct: 416 AIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLK 475
Query: 541 SMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKG--NKE 598
+ +FA+ + + ++ KL+ +V+ PGDYI ++G IG++MY I+ G ++V+ +
Sbjct: 476 KVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQF 535
Query: 599 MKLSDGSYFGEICLL------TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAF 652
+ LSDGSYFGEI +L RRTA++++ Y L+ LS D+ E L EYP +
Sbjct: 536 VVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTML 595
Query: 653 E 653
E
Sbjct: 596 E 596
>gi|27437001 potassium voltage-gated channel, subfamily H, member 1
isoform 1 [Homo sapiens]
Length = 989
Score = 165 bits (418), Expect = 2e-40
Identities = 135/577 (23%), Positives = 243/577 (42%), Gaps = 71/577 (12%)
Query: 184 GSQKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDETTAP 243
GS + +QE K+ I+H Y F+ WD+ +L+ I++P ++F +
Sbjct: 191 GSDILPQYKQEAPKTPPHIILH-YCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVA 249
Query: 244 WIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDY 303
W+V + + D FL+D+VLNF T V E+I DP+ I+ YL+TWFV+D +S +P D
Sbjct: 250 WLVVDSIVDVIFLVDIVLNFHTTFV-GPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDV 308
Query: 304 I--FLIVEK-----------GIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQW 350
I F V++ G ++ + + S L+++RL RL R +
Sbjct: 309 INAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKL 368
Query: 351 EEIFHMTYDLASAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFP-------RNCWV--- 400
+ ++ Y A V+ +C + L HW C+ + + + F N W+
Sbjct: 369 DH--YIEYGAAVLVLLVC----VFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQL 422
Query: 401 --------SINGMVNHSW------SELYSFALFKAMSHMLCIGYGRQAPESMTDIWLTML 446
NG + W + +Y +L+ M+ + +G+G AP + + +
Sbjct: 423 AMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVA 482
Query: 447 SMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEH 506
M++G+ YA G+ T + Q + ++ +Y E V ++ +++P +++ DY
Sbjct: 483 IMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVS 542
Query: 507 RY-QGKMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVF 565
+ + D + +L +R +I RK+ P F A + A+ + +
Sbjct: 543 TWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHC 602
Query: 566 QPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGEICL--LTRGRRTASVR 623
PGD I G + F+ G + V+ L G FG++ T + A+VR
Sbjct: 603 APGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVR 662
Query: 624 ADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLHKVQHDLNSGVF 683
A TYC L+ + D +VLE Y +F +N IL +
Sbjct: 663 ALTYCDLHVIKRDALQKVLEFYTAFSHSF------------SRNLIL-----------TY 699
Query: 684 NNQENAIIQEIVKYDREMVQQAELGQRVGLFPPPPPP 720
N ++ + ++I RE ++ + L PP P
Sbjct: 700 NLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHP 736
>gi|27886667 potassium voltage-gated channel, subfamily H, member 8
[Homo sapiens]
Length = 1107
Score = 160 bits (406), Expect = 4e-39
Identities = 121/529 (22%), Positives = 236/529 (44%), Gaps = 69/529 (13%)
Query: 202 WIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDE---TTAPWIVFNVVSDTFFLMD 258
+I+ +S F+ WD+ +LL + +P + F ++ TT V ++ + F++D
Sbjct: 212 FILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGNDDLSTTRSTTVSDIAVEILFIID 271
Query: 259 LVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDYIFLIVEKGIDSEVYK 318
++LNFRT V + ++I + I Y+ TWF++D ++++P D ++
Sbjct: 272 IILNFRTTYVSKSG-QVIFEARSICIHYVTTWFIIDLIAALPFDLLY------------- 317
Query: 319 TARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICNLISMMLLLC 378
A + +V +L +RLLRL RL++ + ++ + H T L L+SM LL
Sbjct: 318 -AFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQ--HSTIVLTL-------LMSMFALLA 367
Query: 379 HWDGCLQFLVPMLQDFPRNC------------------WVSINGMVNHSWSELYSFALFK 420
HW C+ +++ ++ + + N + S Y AL+
Sbjct: 368 HWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYIAALYF 427
Query: 421 AMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKY 480
+S + +G+G + + + ++ +M++GA +A+ G+ TA+IQ + S Y +
Sbjct: 428 TLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRT 487
Query: 481 KQVEQYMSFHKLPADFRQKIHDYYEHRYQ-GKMFDEDSILGELNGPLREEIVNFNCRKLV 539
K ++ ++ H LP +Q++ +Y++ + D + +L + LR +I + K +
Sbjct: 488 KDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDI-TMHLNKEI 546
Query: 540 ASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEM 599
+ LF A + ++ +K PG+Y++R+G + +YF+ G + VL
Sbjct: 547 LQLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMVLA 606
Query: 600 KLSDGSYFGEICLLTRG--RRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAI 657
L G G + + A V+A TYC L + + EVL+ YP F
Sbjct: 607 ILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPEYAHKF----- 661
Query: 658 DRLDRIGKKNSILLHKVQHDLNSGVFNNQENAIIQEIVKYDREMVQQAE 706
+ +QHDL + E+ +I + ++ MV Q+E
Sbjct: 662 -------------VEDIQHDLTYNLREGHESDVISRL--SNKSMVSQSE 695
>gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [Homo
sapiens]
Length = 1251
Score = 157 bits (398), Expect = 3e-38
Identities = 145/613 (23%), Positives = 266/613 (43%), Gaps = 70/613 (11%)
Query: 214 WDFTMLLFMVGNLIIIPV--GITFFKDETTAPWIVFNVVSDTFFLMDLVLNFRTGIVIED 271
W F +++ N +IPV + + W++ + + D + +D+ + F+T +
Sbjct: 659 WLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITV-FQTRLQFVR 717
Query: 272 NTEIILDPEKIKKKYLRTW-FVVDFVSSIPVDYIFLIVEKGIDSEVYKTARALRIVRFTK 330
+II D + ++ YL++ F +D +S +P+D+++L V G++
Sbjct: 718 GGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKV--GVNP---------------- 759
Query: 331 ILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASA-VMRICNLISMMLLLCHWDGCLQFLVP 389
LLRL R ++Y+ +E + L+ A V R+ + +L H + CL +
Sbjct: 760 ------LLRLPRCLKYMAFFEFNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWAS 813
Query: 390 MLQDFPRNCWVSINGMVNHSWSELYSFALFKAMSHMLCIGYGRQAPESMTDIWLTMLSMI 449
Q WV V +S+ Y FA+ ++ IG G P+++ +I +L+
Sbjct: 814 AYQGLGSTHWVYDG--VGNSYIRCYYFAV----KTLITIG-GLPDPKTLFEIVFQLLNYF 866
Query: 450 VGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQ 509
G +++ IG ++ + + + Y+ +YM+F+K+P + ++ +YE+ +
Sbjct: 867 TGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWH 926
Query: 510 GK-MFDEDSILGELNGPLREEI---VNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVF 565
+ M DE ++ +L +R ++ VN+N +V+ + LF D + ML +L+ V+
Sbjct: 927 SQGMLDESELMVQLPDKMRLDLAIDVNYN---IVSKVALFQGCDRQMIFDMLKRLRSVVY 983
Query: 566 QPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKE---MKLSDGSYFGEICLLTRG---RRT 619
P DY+ ++G IG++MY IQ G V VL + + + L GS FGEI LL G RRT
Sbjct: 984 LPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVFGEISLLAVGGGNRRT 1043
Query: 620 ASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLHKVQHDLN 679
A+V A + L+ L + NE+L YP + +L K + L
Sbjct: 1044 ANVVAHGFTNLFILDKKDLNEILVHYP------------------ESQKLLRKKARRMLR 1085
Query: 680 SGVFNNQENAIIQEIVKYDREMVQQAELGQRVGLFPPPPPPPQVTSAIATLQQAAAMSFC 739
S +E +++ + + A L + ++ A L++ AA+
Sbjct: 1086 SNNKPKEEKSVLILPPRAGTPKLFNAALAMTGKMGGKGAKGGKLAHLRARLKELAALEAA 1145
Query: 740 ---PQVARPLVGPLALGSPRLVRRPPPGPAPAAASPGPPPPASPPGAPASPRAPRTSPYG 796
++ + P P A+ PP P +PP P SP +
Sbjct: 1146 AKQQELVEQAKSSQDVKGEEGSAAPDQHTHPKEAATDPPAPRTPPEPPGSPPSSPPPASL 1205
Query: 797 GLPAAPLAGPALP 809
G P GPA P
Sbjct: 1206 GRPEGEEEGPAEP 1218
Score = 39.3 bits (90), Expect = 0.016
Identities = 18/49 (36%), Positives = 22/49 (44%)
Query: 21 GPPPPPPPAPPQQQPPPPPPPAPPPGPGPAPPQHPPRAEALPPEAADEG 69
G P P++ PP P PP P +PP PP A PE +EG
Sbjct: 1166 GSAAPDQHTHPKEAATDPPAPRTPPEPPGSPPSSPPPASLGRPEGEEEG 1214
Score = 37.0 bits (84), Expect = 0.081
Identities = 20/46 (43%), Positives = 23/46 (50%), Gaps = 4/46 (8%)
Query: 10 PGESPGATPAPGPPPPPPPAPPQQQPPPPPPPAPPPG--PGPAPPQ 53
P E+ PAP PP PP +PP PPP P G GPA P+
Sbjct: 1176 PKEAATDPPAPRTPPEPPGSPPSS--PPPASLGRPEGEEEGPAEPE 1219
Score = 34.7 bits (78), Expect = 0.40
Identities = 20/55 (36%), Positives = 22/55 (40%), Gaps = 1/55 (1%)
Query: 11 GESPGATPAPGPPPPPPPA-PPQQQPPPPPPPAPPPGPGPAPPQHPPRAEALPPE 64
GE A P P PP + PP PP +PP P PA P E P E
Sbjct: 1163 GEEGSAAPDQHTHPKEAATDPPAPRTPPEPPGSPPSSPPPASLGRPEGEEEGPAE 1217
Score = 33.1 bits (74), Expect = 1.2
Identities = 20/56 (35%), Positives = 23/56 (41%), Gaps = 5/56 (8%)
Query: 8 GRPGESPGATPAPGPPPPPPPAPPQQQPPPPPPPAPPPGPGPAPPQHPPRAEALPP 63
GRP E A P P P P Q + P PAP P PG + +LPP
Sbjct: 198 GRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPAPEPQPG-----SQAQTSSLPP 248
Score = 31.6 bits (70), Expect = 3.4
Identities = 18/63 (28%), Positives = 22/63 (34%), Gaps = 2/63 (3%)
Query: 2 DARGGGGRPGESPGATPAPGPPPPPPPAPPQQQPPPPPPPAPPPGPGPAPPQHPPRAEAL 61
D +G G P PP P P + PP PP+ PP P+ A
Sbjct: 1160 DVKGEEGSAAPDQHTHPKEAATDPPAPRTPPE--PPGSPPSSPPPASLGRPEGEEEGPAE 1217
Query: 62 PPE 64
P E
Sbjct: 1218 PEE 1220
>gi|38569493 potassium voltage-gated channel, subfamily H
(eag-related), member 3 [Homo sapiens]
Length = 1083
Score = 154 bits (388), Expect = 5e-37
Identities = 178/750 (23%), Positives = 300/750 (40%), Gaps = 115/750 (15%)
Query: 174 GVNKFSLRMFGSQKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIIIP--V 231
G +K + +FG + + + +I+ R WD +LL + + +P V
Sbjct: 187 GKHKLNKGVFGEKPNLPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAVTVPYSV 246
Query: 232 GITFFKDETTA--PWIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRT 289
++ ++ + A P V ++ + F++D+VLNFRT V + +++ P+ I Y+ T
Sbjct: 247 CVSTAREPSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSG-QVVFAPKSICLHYVTT 305
Query: 290 WFVVDFVSSIPVDYIFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLL-RLSRLIRYIH 348
WF++D ++++P D + VY A L+ VR +L LLRLL RL R +Y
Sbjct: 306 WFLLDVIAALPFDLLH-----AFKVNVYFGAHLLKTVR---LLRLLRLLPRLDRYSQY-- 355
Query: 349 QWEEIFHMTYDLASAVMRICNLISMMLLLCHWDGCLQFLVPMLQ------DFPRNCWV-- 400
SAV+ + L+++ LL HW C+ F + + + P W+
Sbjct: 356 -------------SAVV-LTLLMAVFALLAHWVACVWFYIGQREIESSESELPEIGWLQE 401
Query: 401 ----------------------------SINGMVNHSWSEL---------YSFALFKAMS 423
S + N + EL Y +L+ A+S
Sbjct: 402 LARRLETPYYLVGRRPAGGNSSGQSDNCSSSSEANGTGLELLGGPSLRSAYITSLYFALS 461
Query: 424 HMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQV 483
+ +G+G + + T+ ++ +M++GA +A+ G+ TA+IQ + + R Y + + +
Sbjct: 462 SLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDL 521
Query: 484 EQYMSFHKLPADFRQKIHDYYEHRYQ-GKMFDEDSILGELNGPLREEIVNFNCRKLVASM 542
Y+ H++P +Q++ +Y++ + D +L L LR +I + K V +
Sbjct: 522 RDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQSLPDELRADIA-MHLHKEVLQL 580
Query: 543 PLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLS 602
PLF A + A+ L+ PG+Y+I +G + +YF+ G + VL G L
Sbjct: 581 PLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQALYFVCSGSMEVLKGGTVLAILG 640
Query: 603 DGSYFGEICLLTRGRRTASVRAD----TYCRLYSLSVDNFNEVLEEYPMMRRAFETVAID 658
G G C L R + AD TYC L L + ++ L YP F
Sbjct: 641 KGDLIG--CELPRREQVVKANADVKGLTYCVLQCLQLAGLHDSLALYPEFAPRFSRGLRG 698
Query: 659 RLD-RIGKKNSILLHKVQHDLNSGVFNNQENAIIQEIVKYDREMVQQAELGQRVGLFPPP 717
L +G + D +S + +N ++ + E E G V P
Sbjct: 699 ELSYNLGAGGG----SAEVDTSS---LSGDNTLMSTL----EEKETDGEQGPTVSPAPAD 747
Query: 718 PPPPQVTSAIATLQQAAAMSFCPQVARPLVGPLALGSPRLVRRPPPGPAPAAASPGPPPP 777
P + S T +AA P+ P PRL R PG A A + P
Sbjct: 748 EPSSPLLSPGCTSSSSAAKLLSPRRTAP--------RPRLGGRGRPGRAGALKAEA--GP 797
Query: 778 ASPPGAPASPRAPRTSPYGGLPAAPLAGPALPARRLSRASRPLSASQP--SLPHGAPGPA 835
++PP A R P P P L R + + QP S G GP
Sbjct: 798 SAPPRALEGLRLP--------PMPWNVPPDLSPRVVDGIEDGCGSDQPKFSFRVGQSGPE 849
Query: 836 ASTRPASSSTPRLGPTPAARAAAPSPDRRD 865
S+ P+ L P + A + D D
Sbjct: 850 CSSSPSPGPESGLLTVPHGPSEARNTDTLD 879
Score = 33.9 bits (76), Expect = 0.69
Identities = 35/129 (27%), Positives = 41/129 (31%), Gaps = 32/129 (24%)
Query: 12 ESPGATPAPGPPPPPPPAPPQQQPPPPPPPAPPPGPGPAPPQHP-PRAEALPPEAADEGG 70
+ P + G P P +P PPP AP P PA P PRA A +D
Sbjct: 950 QPPAGSVLSGTWPHP-------RPGPPPLMAPWPWGPPASQSSPWPRATAFWTSTSDSEP 1002
Query: 71 PRGRLRSRDSSCGRPGTPGAASTAKGSPNGECGRGEPQCSPAGPEGPARGPKVSFSCRGA 130
P + C P TP + P EG GP S A
Sbjct: 1003 P-----ASGDLCSEPSTPAS-------------------PPPSEEGARTGPAEPVSQAEA 1038
Query: 131 ASGPAPGPG 139
S P PG
Sbjct: 1039 TSTGEPPPG 1047
Score = 32.3 bits (72), Expect = 2.0
Identities = 30/99 (30%), Positives = 37/99 (37%), Gaps = 24/99 (24%)
Query: 15 GATPAPGPPPPP-----PPAPPQQQPPPPP---------PPAPPPGPG-----PAPPQHP 55
G P P P PPP P PP Q P P + PP G P+ P P
Sbjct: 959 GTWPHPRPGPPPLMAPWPWGPPASQSSPWPRATAFWTSTSDSEPPASGDLCSEPSTPASP 1018
Query: 56 PRAEALPPEAADEGGPRGRLRSRDSSCGRPGTPGAASTA 94
P +E E A G ++ +S G P PG+ A
Sbjct: 1019 PPSE----EGARTGPAEPVSQAEATSTGEP-PPGSGGLA 1052
Score = 31.6 bits (70), Expect = 3.4
Identities = 18/40 (45%), Positives = 20/40 (50%), Gaps = 1/40 (2%)
Query: 5 GGGGRPGESPGATPAPGPPPPPPPAPPQQQPPPPPPPAPP 44
GG GRPG + GA A P PP A + PP P PP
Sbjct: 780 GGRGRPGRA-GALKAEAGPSAPPRALEGLRLPPMPWNVPP 818
Score = 30.0 bits (66), Expect = 10.0
Identities = 46/165 (27%), Positives = 60/165 (36%), Gaps = 39/165 (23%)
Query: 719 PPPQVTSAIAT--LQQAAAMSFCPQVARPLVGPLALGSPRLVRRPPPGPAPAAASPGPPP 776
P P TS + A S+C Q P G + G+ P PGP P A P
Sbjct: 926 PCPASTSGLLQPLCVDTGASSYCLQ---PPAGSVLSGT---WPHPRPGPPPLMA----PW 975
Query: 777 PASPPGAPASPRAPRTSPYGGLPAAPLAGPALPARRLSRASRPLS---ASQPSLPHGAPG 833
P PP + +SP PR + + S + P S S+PS P
Sbjct: 976 PWGPPASQSSP-WPRATAFW--------------TSTSDSEPPASGDLCSEPSTP----- 1015
Query: 834 PAASTRPASSSTPRLGPT-PAARAAAPSPDRRDSASPGAAGGLDP 877
++ P S R GP P ++A A S S G A DP
Sbjct: 1016 ---ASPPPSEEGARTGPAEPVSQAEATSTGEPPPGSGGLALPWDP 1057
>gi|26051271 voltage-gated potassium channel, subfamily H, member 2
isoform b [Homo sapiens]
Length = 888
Score = 150 bits (380), Expect = 4e-36
Identities = 104/418 (24%), Positives = 189/418 (45%), Gaps = 52/418 (12%)
Query: 202 WIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDETTA------------PWIVFNV 249
W I YS F+ WD+ +LL ++ + P F ET P V ++
Sbjct: 398 WTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDL 457
Query: 250 VSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDYIFLIVE 309
+ D F++D+++NFRT V N E++ P +I Y + WF++D V++IP D +
Sbjct: 458 IVDIMFIVDILINFRTTYV-NANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIF--- 513
Query: 310 KGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICN 369
G SE +L RLLRL R+ R + ++ E Y A + +C
Sbjct: 514 -GSGSE-----------ELIGLLKTARLLRLVRVARKLDRYSE-----YGAAVLFLLMCT 556
Query: 370 LISMMLLLCHWDGCLQFLVPMLQD---FPRNCWV-----------SINGMVNHSWSELYS 415
L+ HW C+ + + ++ R W+ + +G+ S + Y
Sbjct: 557 FA----LIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYV 612
Query: 416 FALFKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQ 475
AL+ S + +G+G +P + ++ ++ M++G+ YA G+ +A+IQ L S +
Sbjct: 613 TALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTAR 672
Query: 476 YQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQ-GKMFDEDSILGELNGPLREEIVNFN 534
Y + +V +++ FH++P RQ++ +Y++H + D +++L L+ +I
Sbjct: 673 YHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHL 732
Query: 535 CRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVL 592
R L+ F A + A+ K K PGD ++ G + +YFI G + +L
Sbjct: 733 NRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEIL 790
>gi|27886646 potassium voltage-gated channel, subfamily H, member 5
isoform 3 [Homo sapiens]
Length = 611
Score = 149 bits (375), Expect = 1e-35
Identities = 112/435 (25%), Positives = 194/435 (44%), Gaps = 50/435 (11%)
Query: 184 GSQKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDETTAP 243
GS + +QE K+ I+H Y F+ WD+ +L+ I++P ++F +
Sbjct: 188 GSDILPQYKQEAPKTPPHIILH-YCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIA 246
Query: 244 WIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDY 303
W+V + V D FL+D+VLNF T V E+I DP+ I+ YL+TWFV+D +S +P D
Sbjct: 247 WLVLDSVVDVIFLVDIVLNFHTTFV-GPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDI 305
Query: 304 I--FLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLA 361
I F V++GI S L ++RLLRL R+ R + + E Y A
Sbjct: 306 INAFENVDEGISS-------------LFSSLKVVRLLRLGRVARKLDHYLE-----YGAA 347
Query: 362 SAVMRICNLISMMLLLCHWDGCLQFLV-------PMLQDFPRNCW-----VSINGMVNHS 409
V+ +C + L+ HW C+ + + + + W +SI ++
Sbjct: 348 VLVLLVC----VFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYN 403
Query: 410 WS-----------ELYSFALFKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMF 458
S LY +L+ M+ + IG+G AP + + ++ M+VG+ YA
Sbjct: 404 TSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATI 463
Query: 459 IGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRY-QGKMFDEDS 517
G+ T + Q + ++ +Y E V ++ +++P +++ DY + K D +
Sbjct: 464 FGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEK 523
Query: 518 ILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTI 577
+L +R +I RK+ P F A + A+ + + PGD I G
Sbjct: 524 VLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGES 583
Query: 578 GKKMYFIQHGVVSVL 592
+ F+ G + V+
Sbjct: 584 VDALCFVVSGSLEVI 598
>gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]
Length = 809
Score = 134 bits (337), Expect = 4e-31
Identities = 115/462 (24%), Positives = 205/462 (44%), Gaps = 50/462 (10%)
Query: 204 IHPYSDFRFY--WDFTMLLFMVGNLIIIPVGITFFKD--ETTAPWIVFNVVSDTFFLMDL 259
I Y+D R Y W + L N IP+ + F + W++ +++ D +L D+
Sbjct: 210 IDSYTD-RLYLLWLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDM 268
Query: 260 VLNFRTGIVIEDNTEIILDPEKIKKKY-LRTWFVVDFVSSIPVDYIFLIVEKGIDSEVYK 318
+ + + +II+D +++K Y T F +D S IP D +L
Sbjct: 269 LF-IQPRLQFVRGGDIIVDSNELRKHYRTSTKFQLDVASIIPFDICYLFFG--------- 318
Query: 319 TARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICNLISMMLLLC 378
F + R+L+ + + H E I Y + R+ +L +
Sbjct: 319 ---------FNPMFRANRMLKYTSFFEFNHHLESIMDKAY-----IYRVIRTTGYLLFIL 364
Query: 379 HWDGCLQFLVPMLQDFPRNCWVSINGMVNHSWSELYSFALFKAMSHMLCIGYGRQAPESM 438
H + C+ + + WV +G N Y + A+ ++ IG G P+++
Sbjct: 365 HINACVYYWASNYEGIGTTRWV-YDGEGNE-----YLRCYYWAVRTLITIG-GLPEPQTL 417
Query: 439 TDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQ 498
+I +L+ G ++ IG +I + +++ ++ YM+ + +P ++
Sbjct: 418 FEIVFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLVQK 477
Query: 499 KIHDYYEHRYQG-KMFDEDSILGELNGPLREEI---VNFNCRKLVASMPLFANADPNFVT 554
++ +YE+ + +M DE +L L ++ + VNF+ +++ + LF D +
Sbjct: 478 RVRTWYEYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFS---IISKVDLFKGCDTQMIY 534
Query: 555 AMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVL--TKGNKEM-KLSDGSYFGEIC 611
ML +LK ++ PGD++ ++G IGK+MY I+HG V VL G K + L GS FGEI
Sbjct: 535 DMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGTKVLVTLKAGSVFGEIS 594
Query: 612 LLTRG---RRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRR 650
LL G RRTA+V A + L +L E+L YP R
Sbjct: 595 LLAAGGGNRRTANVVAHGFANLLTLDKKTLQEILVHYPDSER 636
>gi|27886665 potassium voltage-gated channel, subfamily H, member 7
isoform 2 [Homo sapiens]
Length = 732
Score = 132 bits (332), Expect = 1e-30
Identities = 87/334 (26%), Positives = 161/334 (48%), Gaps = 53/334 (15%)
Query: 203 IIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDE-----------TTAPWIVFNVVS 251
I+H YS F+ WD+ +LL ++ I P F ++ + +P V +++
Sbjct: 393 ILH-YSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIV 451
Query: 252 DTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDYIFLIVEKG 311
D F++D+++NFRT V N E++ DP KI Y + WF++D V++IP D LI G
Sbjct: 452 DIMFIIDILINFRTTYV-NQNEEVVSDPAKIAIHYFKGWFLIDMVAAIPFD--LLIFGSG 508
Query: 312 IDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICNLI 371
D T ++ LL+ RL RL+R + + + Y A ++ +C
Sbjct: 509 SDET-------------TTLIGLLKTARLLRLVRVARKLDR--YSEYGAAVLMLLMC--- 550
Query: 372 SMMLLLCHWDGCLQFLV-----PMLQDFPRNCWVSINGMV------------NHSWSELY 414
+ L+ HW C+ + + P L D + W+ G S + Y
Sbjct: 551 -IFALIAHWLACIWYAIGNVERPYLTD--KIGWLDSLGQQIGKRYNDSDSSSGPSIKDKY 607
Query: 415 SFALFKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRR 474
AL+ S + +G+G +P + ++ ++ M++G+ YA G+ +A+IQ L S
Sbjct: 608 VTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTA 667
Query: 475 QYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRY 508
+Y + +V++++ FH++P RQ++ +Y++H +
Sbjct: 668 RYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAW 701
>gi|4826998 splicing factor proline/glutamine rich (polypyrimidine
tract binding protein associated) [Homo sapiens]
Length = 707
Score = 80.1 bits (196), Expect = 8e-15
Identities = 59/164 (35%), Positives = 67/164 (40%), Gaps = 19/164 (11%)
Query: 7 GGRPGESPGATPAPGPPP------PPPPAPPQQQPPP-PPPPAPPPGPGPAPPQHPPRAE 59
G PG+S P P PPP PPP PP QQPPP PPP P P PP PP +
Sbjct: 48 GPGPGQSGPKPPIPPPPPHQQQQQPPPQQPPPQQPPPHQPPPHPQPHQQQQPP--PPPQD 105
Query: 60 ALPPEAADEGGPRGRLRSRD--SSCGRPGTPGAASTAKGSPNGECGRGEPQCSPAGPEGP 117
+ P A GP + S SS P TP + GS G P + A P P
Sbjct: 106 SSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTSGAPPGSGPGPTPTPPPAVTSAPPGAP 165
Query: 118 ARGPKVSF--SCRGAASGP------APGPGPAEEAGSEEAGPAG 153
P S + A GP PGPGP + G GP G
Sbjct: 166 PPTPPSSGVPTTPPQAGGPPPPPAAVPGPGPGPKQGPGPGGPKG 209
Score = 67.0 bits (162), Expect = 7e-11
Identities = 56/162 (34%), Positives = 63/162 (38%), Gaps = 42/162 (25%)
Query: 7 GGRPGESPGATPAP------GPPPPPPPAPPQQQPP--------PPPPPAPPPGPGPAPP 52
G PG PG TP P PP PPP PP P PPPPPA PGPGP P
Sbjct: 140 GAPPGSGPGPTPTPPPAVTSAPPGAPPPTPPSSGVPTTPPQAGGPPPPPAAVPGPGPGPK 199
Query: 53 QHPPRAEALPPEAADEGGPR-GRLRSRDSSCGRPG--TPGAASTAKGSPNGECGRGEPQC 109
Q P GGP+ G++ G PG TPG GE RG Q
Sbjct: 200 QGP-----------GPGGPKGGKMPGGPKPGGGPGLSTPGGHPKPPHRGGGE-PRGGRQH 247
Query: 110 SPAGPEGPARGPKVSFSCRGAASGPAPGP-GPAEEAGSEEAG 150
P + +GP P GP G +EE S+ G
Sbjct: 248 HPPYHQQHHQGP------------PPGGPGGRSEEKISDSEG 277
Score = 56.2 bits (134), Expect = 1e-07
Identities = 48/166 (28%), Positives = 63/166 (37%), Gaps = 25/166 (15%)
Query: 715 PPPPPPPQVTSAIATLQQAAAMSFCPQVARPLVGPLALGSPRLVRRPPPGPAPA-----A 769
P PPPPP QQ P P P P ++PPP P + A
Sbjct: 59 PIPPPPPHQQQQQPPPQQP------PPQQPPPHQPPPHPQPHQQQQPPPPPQDSSKPVVA 112
Query: 770 ASPGPPPP--ASPPGAPASPRAPRTSPYGGLPAAPLAGPALPARRLSRASRPLSASQPSL 827
PGP P ++PP + ++P P T P G P GP + P + + S
Sbjct: 113 QGPGPAPGVGSAPPASSSAP--PATPPTSGAPPGSGPGPT--------PTPPPAVT--SA 160
Query: 828 PHGAPGPAASTRPASSSTPRLGPTPAARAAAPSPDRRDSASPGAAG 873
P GAP P + ++ P+ G P AA P P PG G
Sbjct: 161 PPGAPPPTPPSSGVPTTPPQAGGPPPPPAAVPGPGPGPKQGPGPGG 206
Score = 53.9 bits (128), Expect = 6e-07
Identities = 44/142 (30%), Positives = 50/142 (35%), Gaps = 12/142 (8%)
Query: 717 PPPPPQVTSAIATLQ---QAAAMSFCPQV---ARPLVGPLALGSPRLVRRPPPGPAPAAA 770
PPPPPQ +S Q A + P A P P + P P P P PA
Sbjct: 99 PPPPPQDSSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTSGAPPGSGPGPTPTPPPAVT 158
Query: 771 SPGPPPPASPPGAPASPRAPRTSPYGGLPAAPLA---GPALPARRLSRASRPLSASQPSL 827
S PP +PP P S P T P G P P A GP ++ P P
Sbjct: 159 S---APPGAPPPTPPSSGVPTTPPQAGGPPPPPAAVPGPGPGPKQGPGPGGPKGGKMPGG 215
Query: 828 PHGAPGPAASTRPASSSTPRLG 849
P GP ST P G
Sbjct: 216 PKPGGGPGLSTPGGHPKPPHRG 237
Score = 53.9 bits (128), Expect = 6e-07
Identities = 50/160 (31%), Positives = 55/160 (34%), Gaps = 45/160 (28%)
Query: 3 ARGGGGRPGES---PGATPAPGPPPPPPPAPPQQQP---PPPPPPAPPPGPGPAPPQHPP 56
A+G G PG P ++ AP PP APP P P PPP PG APP PP
Sbjct: 112 AQGPGPAPGVGSAPPASSSAPPATPPTSGAPPGSGPGPTPTPPPAVTSAPPG-APPPTPP 170
Query: 57 RAEALPPEAADEGGPRGRLRSRDSSCGRPGTPGAASTAKGSPNGECGRGEPQCSPAGPEG 116
S G P TP A G P PA G
Sbjct: 171 ------------------------SSGVPTTPPQA-------------GGPPPPPAAVPG 193
Query: 117 PARGPKVSFSCRGAASGPAPGPGPAEEAGSEEAGPAGEPR 156
P GPK G G PG GP G + P G P+
Sbjct: 194 PGPGPKQGPGPGGPKGGKMPG-GPKPGGGPGLSTPGGHPK 232
Score = 47.4 bits (111), Expect = 6e-05
Identities = 41/154 (26%), Positives = 52/154 (33%), Gaps = 28/154 (18%)
Query: 748 GPLALGSPRLVRRPPPGPAPAAASPGPPPPASPPGAPASPRAPRTSPY------------ 795
GP+ G + +PP P P PPP PP P P P
Sbjct: 45 GPMGPGPGQSGPKPPIPPPPPHQQQQQPPPQQPPPQQPPPHQPPPHPQPHQQQQPPPPPQ 104
Query: 796 --------GGLPAAPLAGPALPARRLSRASRPLSASQPSLPHGAPGPAASTRPASSSTPR 847
G AP G A PA + + P ++ P P PGP + PA +S P
Sbjct: 105 DSSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTSGAP--PGSGPGPTPTPPPAVTSAPP 162
Query: 848 LGPTPAARAAAPSPDRRDSASPGAAGGLDPQDSA 881
P P P +P AGG P +A
Sbjct: 163 GAPPPT------PPSSGVPTTPPQAGGPPPPPAA 190
Score = 45.8 bits (107), Expect = 2e-04
Identities = 44/133 (33%), Positives = 47/133 (35%), Gaps = 10/133 (7%)
Query: 715 PPPPPPPQVTSAIATLQQAAAMSFCPQVARPLVGPLALGSPRLVRRPP-PGPAPAAA-SP 772
P P PPP VTSA A P P P A G P P PGP P P
Sbjct: 149 PTPTPPPAVTSA----PPGAPPPTPPSSGVPTTPPQAGGPPPPPAAVPGPGPGPKQGPGP 204
Query: 773 GPPPPASPPGAPASPRAPRTSPYGGLPAAPLAGPALPARRLSRASRPLSASQ--PSLPHG 830
G P PG P P S GG P P G P R R P Q P G
Sbjct: 205 GGPKGGKMPGGPKPGGGPGLSTPGGHPKPPHRGGGEP--RGGRQHHPPYHQQHHQGPPPG 262
Query: 831 APGPAASTRPASS 843
PG + + + S
Sbjct: 263 GPGGRSEEKISDS 275
Score = 32.3 bits (72), Expect = 2.0
Identities = 24/75 (32%), Positives = 29/75 (38%), Gaps = 6/75 (8%)
Query: 6 GGGRPGESPGATPAPGPPPPPPPAPPQQQPPPPPPPAPPPGPGPAPPQHPPRAEALPPEA 65
GG + G+ PG P PG P +PP P G PP H + PP
Sbjct: 205 GGPKGGKMPG-GPKPGGGPGLSTPGGHPKPPHRGGGEPRGGRQHHPPYHQQHHQGPPP-- 261
Query: 66 ADEGGPRGRLRSRDS 80
GGP GR + S
Sbjct: 262 ---GGPGGRSEEKIS 273
>gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1
preproprotein [Homo sapiens]
Length = 331
Score = 72.4 bits (176), Expect = 2e-12
Identities = 54/170 (31%), Positives = 70/170 (41%), Gaps = 21/170 (12%)
Query: 7 GGRPGESP-GATPAPGPPPPP--PPAPPQQ---QPPPPPPPAPPPGPGP------APPQH 54
G G SP G GPPPPP P PP Q +P PPPP P GP P +P
Sbjct: 34 GNPQGPSPQGGNKPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSP 93
Query: 55 PPRAEALPPEAADEGGPRGRLRSRDSSCGRP---GTPGAASTAKGSPNGECGRGEPQCSP 111
P + + PP+ ++ P+G G P G G P G +G+ SP
Sbjct: 94 PGKPQGPPPQGGNQ--PQGPPPPPGKPQGPPPQGGNRPQGPPPPGKPQGPPPQGDKSRSP 151
Query: 112 AGPEGPARGPKVSFSCRGAASGPAPG--PGPAEEAGSEEAG--PAGEPRG 157
P G +GP + P PG GP + G + G P G+P+G
Sbjct: 152 RSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGKKPQGPPPPGKPQG 201
Score = 68.6 bits (166), Expect = 3e-11
Identities = 55/181 (30%), Positives = 73/181 (40%), Gaps = 17/181 (9%)
Query: 6 GGGRPGESPGATPAPGPPPPPPPAP---PQQQPPPPPPPAPPP-GPGPAPPQHPP-RAEA 60
GG +P G P PG P PPP PQ PPP P PPP G P+ PP + +
Sbjct: 104 GGNQP---QGPPPPPGKPQGPPPQGGNRPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQG 160
Query: 61 LPPEAADEGGPRGRLRSRDSSCGRP---GTPGAASTAKGSPNGECGRGEPQCSPAGPEGP 117
PP+ ++ P+G G P G G P G +G+ S P G
Sbjct: 161 PPPQGGNQ--PQGPPPPPGKPQGPPPQGGKKPQGPPPPGKPQGPPPQGDKSRSSQSPPGK 218
Query: 118 ARGPKVSFSCRGAASGPAPG--PGPAEEAGSEEAG--PAGEPRGSQASFMQRQFGALLQP 173
+GP + P PG GP + G++ G P G+P+G A + A P
Sbjct: 219 PQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPAQGGSKSQSARSPP 278
Query: 174 G 174
G
Sbjct: 279 G 279
Score = 67.4 bits (163), Expect = 6e-11
Identities = 56/186 (30%), Positives = 71/186 (38%), Gaps = 33/186 (17%)
Query: 6 GGGRPGESPGATPAPGPPPP--------PPPAPPQQQPP-----PPPPPAPPPGPGPAPP 52
GG RP P GPPP PP PQ PP P PP PP P PP
Sbjct: 125 GGNRPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPP 184
Query: 53 QHPPRAEALPPEAADEGGP--RGRLRSRDSSCGRP--------GTPGAASTAKGSPNGEC 102
Q + + PP +G P + RS S G+P P G P G
Sbjct: 185 QGGKKPQGPPPPGKPQGPPPQGDKSRSSQSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPP 244
Query: 103 GRG--EPQCSPAGPEGPARGPKVSFSCRGAASGPAPG--PGPAEEAGSEEAGP----AGE 154
+G +PQ P P G +GP + ++ PG GP ++ G+ GP G
Sbjct: 245 PQGGNKPQGPP--PPGKPQGPPAQGGSKSQSARSPPGKPQGPPQQEGNNPQGPPPPAGGN 302
Query: 155 PRGSQA 160
P+ QA
Sbjct: 303 PQQPQA 308
Score = 61.6 bits (148), Expect = 3e-09
Identities = 44/136 (32%), Positives = 54/136 (39%), Gaps = 24/136 (17%)
Query: 11 GESPGATPAPGPP--PPP----------PPAPPQQQPP-----PPPPPAPPPGPGPAPPQ 53
G+ P P PG P PPP PP PQ PP P PP PP P PPQ
Sbjct: 187 GKKPQGPPPPGKPQGPPPQGDKSRSSQSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQ 246
Query: 54 HPPRAEALPPEAADEGGPRGRLRSRDSSCGRPGTPGAASTAKGS------PNGECGRGEP 107
+ + PP +G P S+ PG P +G+ P +P
Sbjct: 247 GGNKPQGPPPPGKPQGPPAQGGSKSQSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQP 306
Query: 108 QCSPAG-PEGPARGPK 122
Q PAG P+GP R P+
Sbjct: 307 QAPPAGQPQGPPRPPQ 322
Score = 52.4 bits (124), Expect = 2e-06
Identities = 41/133 (30%), Positives = 50/133 (37%), Gaps = 16/133 (12%)
Query: 754 SPRLVRRPPPGPAPAAAS--PGPPPPASPPGAPASPRAPRTSPYGGLPAAPLAGPALPAR 811
SP L+ P GP+P + GPPPP P P P P G P GP P
Sbjct: 28 SPSLIAGNPQGPSPQGGNKPQGPPPPPGKPQGP--PPQGGNKPQGPPPPGKPQGPP-PQG 84
Query: 812 RLSRASR----------PLSASQPSLPHGAPGPAASTRPASSSTPRLGPTPAARAAAPSP 861
SR+ R P +QP P PG P + P+ GP P + P P
Sbjct: 85 DKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNRPQ-GPPPPGKPQGPPP 143
Query: 862 DRRDSASPGAAGG 874
S SP + G
Sbjct: 144 QGDKSRSPRSPPG 156
Score = 50.4 bits (119), Expect = 7e-06
Identities = 51/182 (28%), Positives = 58/182 (31%), Gaps = 25/182 (13%)
Query: 715 PPPPPPPQVTSAIATLQQAAAMSFCPQVARPLVGPLALGSPRLVRRPPPGPAPAAASPGP 774
PPPP PQ Q P +P GP G R PPG G
Sbjct: 51 PPPPGKPQGPPP----QGGNKPQGPPPPGKPQ-GPPPQGDKSRSPRSPPGKPQGPPPQGG 105
Query: 775 PPPASPPGAPASPRAP----RTSPYGGLPAAPLAGPALPARRLSRASR----------PL 820
P PP P P+ P P G P GP P SR+ R P
Sbjct: 106 NQPQGPPPPPGKPQGPPPQGGNRPQGPPPPGKPQGPP-PQGDKSRSPRSPPGKPQGPPPQ 164
Query: 821 SASQPSLPHGAPGPAASTRPASSSTPRLGPTPAARAAAPSP----DRRDSASPGAAGGLD 876
+QP P PG P P+ GP P + P P R + PG G
Sbjct: 165 GGNQPQGPPPPPGKPQGPPPQGGKKPQ-GPPPPGKPQGPPPQGDKSRSSQSPPGKPQGPP 223
Query: 877 PQ 878
PQ
Sbjct: 224 PQ 225
Score = 49.7 bits (117), Expect = 1e-05
Identities = 54/191 (28%), Positives = 63/191 (32%), Gaps = 36/191 (18%)
Query: 715 PPPP-----PPPQVTSAIATLQQAAAMSFCPQVARPLVGPLALGSPRLVRRP-------- 761
PPPP PPPQ + + PQ P G G P +P
Sbjct: 71 PPPPGKPQGPPPQGDKSRSPRSPPGK----PQGPPPQGGNQPQGPPPPPGKPQGPPPQGG 126
Query: 762 --PPGPAPAAASPGPPP-------PASPPGAPASPRAPRTSPYGG-LPAAPLAGPALPAR 811
P GP P GPPP P SPPG P P P GG P P P P
Sbjct: 127 NRPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGP-----PPQGGNQPQGPPPPPGKPQG 181
Query: 812 RLSR-ASRPLSASQPSLPHGAPGPAASTRPASSSTPR-LGPTPAA--RAAAPSPDRRDSA 867
+ +P P P G P +R + S + GP P + P P
Sbjct: 182 PPPQGGKKPQGPPPPGKPQGPPPQGDKSRSSQSPPGKPQGPPPQGGNQPQGPPPPPGKPQ 241
Query: 868 SPGAAGGLDPQ 878
P GG PQ
Sbjct: 242 GPPPQGGNKPQ 252
Score = 48.5 bits (114), Expect = 3e-05
Identities = 23/67 (34%), Positives = 29/67 (43%)
Query: 8 GRPGESPGATPAPGPPPPPPPAPPQQQPPPPPPPAPPPGPGPAPPQHPPRAEALPPEAAD 67
G P + + + PP P PPQQ+ P P PP G P PQ PP + P
Sbjct: 262 GPPAQGGSKSQSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQPQAPPAGQPQGPPRPP 321
Query: 68 EGGPRGR 74
+GG R
Sbjct: 322 QGGRPSR 328
Score = 46.6 bits (109), Expect = 1e-04
Identities = 45/163 (27%), Positives = 56/163 (34%), Gaps = 26/163 (15%)
Query: 715 PPPP-----PPPQVTSAIATLQQAAAMSFCPQVARPLVGPLALGSPRLVRRPPPGPAPAA 769
PPPP PPPQ + + PQ P G G P +P P
Sbjct: 132 PPPPGKPQGPPPQGDKSRSPRSPPGK----PQGPPPQGGNQPQGPPPPPGKPQGPPPQGG 187
Query: 770 ASP-GPPPPASPPGAPASPRAPRTSPYGGLPAAPLAGPALPARRLSRASRPLSASQPSLP 828
P GPPPP P G P P+ ++ P P P P +QP P
Sbjct: 188 KKPQGPPPPGKPQGPP--PQGDKSRSSQSPPGKPQGPP------------PQGGNQPQGP 233
Query: 829 HGAPGPAASTRPASSSTPRLGPTPAARAAAPSPDRRDSASPGA 871
PG P + P+ GP P + P P + S S A
Sbjct: 234 PPPPGKPQGPPPQGGNKPQ-GPPPPGKPQGP-PAQGGSKSQSA 274
Score = 40.4 bits (93), Expect = 0.007
Identities = 43/156 (27%), Positives = 52/156 (33%), Gaps = 22/156 (14%)
Query: 715 PPPPPPPQVTSAIATLQQAAAMSFCPQVARPLVGPLALGSPRLVRRPPPG----PAPAAA 770
PPPP PQ Q P +P GP G + PPG P P
Sbjct: 173 PPPPGKPQGPPP----QGGKKPQGPPPPGKPQ-GPPPQGDKSRSSQSPPGKPQGPPPQGG 227
Query: 771 S--PGPPPPASPPGAPASPRAPRTSPYGGLPAAPLAGPALPARRLSRASRPLSASQPSLP 828
+ GPPPP P P P P G P GP S+++R S P P
Sbjct: 228 NQPQGPPPPPGKPQGP--PPQGGNKPQGPPPPGKPQGPPAQGGSKSQSAR----SPPGKP 281
Query: 829 HGAP-----GPAASTRPASSSTPRLGPTPAARAAAP 859
G P P PA + + PA + P
Sbjct: 282 QGPPQQEGNNPQGPPPPAGGNPQQPQAPPAGQPQGP 317
Score = 39.7 bits (91), Expect = 0.013
Identities = 40/127 (31%), Positives = 47/127 (37%), Gaps = 19/127 (14%)
Query: 698 DREMVQQAELGQRVGLFPPP--------PPPPQVTSAIATLQQAAAMSFCPQVARPLVGP 749
D+ Q+ G+ G PPP PPPP Q P +P P
Sbjct: 207 DKSRSSQSPPGKPQG--PPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPP 264
Query: 750 LALGSPRLVRRPPPG-----PAPAAASP-GPPPPASPPGAPASPRAPRTSPYGGLPAAPL 803
GS R PPG P +P GPPPPA G P P+AP G P P
Sbjct: 265 AQGGSKSQSARSPPGKPQGPPQQEGNNPQGPPPPAG--GNPQQPQAPPAGQPQGPPRPPQ 322
Query: 804 AG-PALP 809
G P+ P
Sbjct: 323 GGRPSRP 329
Score = 37.7 bits (86), Expect = 0.048
Identities = 24/59 (40%), Positives = 26/59 (44%), Gaps = 5/59 (8%)
Query: 3 ARGGGGRPGESP---GATPAPGPPPPPPPAPPQQQPPPP-PPPAPPPGPGPAPPQHPPR 57
AR G+P P G P GPPPP P Q Q PP P PP P P PP+
Sbjct: 274 ARSPPGKPQGPPQQEGNNPQ-GPPPPAGGNPQQPQAPPAGQPQGPPRPPQGGRPSRPPQ 331
>gi|32307177 forkhead box G1 [Homo sapiens]
Length = 489
Score = 72.0 bits (175), Expect = 2e-12
Identities = 53/160 (33%), Positives = 65/160 (40%), Gaps = 23/160 (14%)
Query: 20 PGPPPPPPPAPPQQQPPPPPPPAPPPGPGPAPPQHPPRAEALPPEAADEGGPRGRLRSRD 79
P PP P PP PPQQQ PPPPPP P P PPQ P A D+ GP+ L
Sbjct: 58 PPPPAPQPPPPPQQQQPPPPPP-----PAPQPPQ-----TRGAPAADDDKGPQQLLLPPP 107
Query: 80 SSCGRPGTPGAASTAKGSPNGECGRGEPQCSPA--GPEGPARGPKVSFSCRGAASGPAPG 137
P P AA+ +G G+GEP P P GP K GA +G
Sbjct: 108 -----PPPPPAAALDGAKADGLGGKGEPGGGPGELAPVGPDEKEK------GAGAGGEEK 156
Query: 138 PGPAEEAGSEEAGPAGEPRGSQASFMQRQFGALLQPGVNK 177
G E E G GE + + + AL+ + +
Sbjct: 157 KGAGEGGKDGEGGKEGEKKNGKYEKPPFSYNALIMMAIRQ 196
Score = 35.0 bits (79), Expect = 0.31
Identities = 36/126 (28%), Positives = 43/126 (34%), Gaps = 30/126 (23%)
Query: 762 PPGPAPAAASPGPPPPAS--PPGAPASPRAPRTSPYGGLPAA-----------PLAGPAL 808
PP PAP P PPP PP P +P+ P+T G PAA P P
Sbjct: 58 PPPPAP---QPPPPPQQQQPPPPPPPAPQPPQTR---GAPAADDDKGPQQLLLPPPPPPP 111
Query: 809 PARRLSRASRPLSASQPSLPHGAPGPAASTRPASSSTPRLGPTPAARAAAPSPDRRDSAS 868
PA L A P G PG A +GP + A + + A
Sbjct: 112 PAAALDGAKAD-GLGGKGEPGGGPGELAP----------VGPDEKEKGAGAGGEEKKGAG 160
Query: 869 PGAAGG 874
G G
Sbjct: 161 EGGKDG 166
Score = 32.7 bits (73), Expect = 1.5
Identities = 28/85 (32%), Positives = 31/85 (36%), Gaps = 13/85 (15%)
Query: 716 PPPPPPQVTSAIATLQQAAAMSFCPQVARPLVGPLA---LGSPRLVRRPPPGPAPAAASP 772
PPPP PQ Q PQ + P A G +L+ PPP P PAAA
Sbjct: 58 PPPPAPQPPPPPQQQQPPPPPPPAPQPPQTRGAPAADDDKGPQQLLLPPPPPPPPAAALD 117
Query: 773 GPP--------PPASPPG--APASP 787
G P PG AP P
Sbjct: 118 GAKADGLGGKGEPGGGPGELAPVGP 142
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.425
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,503,096
Number of Sequences: 37866
Number of extensions: 3615318
Number of successful extensions: 182614
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 2142
Number of HSP's successfully gapped in prelim test: 2283
Number of HSP's that attempted gapping in prelim test: 32974
Number of HSP's gapped (non-prelim): 62231
length of query: 889
length of database: 18,247,518
effective HSP length: 111
effective length of query: 778
effective length of database: 14,044,392
effective search space: 10926536976
effective search space used: 10926536976
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.