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Search of human proteins with 153791484
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|153791484 putative UST1-like organic anion transporter [Homo
sapiens]
(547 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|153791484 putative UST1-like organic anion transporter [Homo ... 1096 0.0
gi|42542386 solute carrier family 22 (organic anion/cation trans... 790 0.0
gi|148664184 solute carrier family 22, member 10 [Homo sapiens] 649 0.0
gi|211059435 solute carrier family 22, member 24 [Homo sapiens] 625 e-179
gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens] 468 e-132
gi|8923870 solute carrier family 22 member 11 [Homo sapiens] 446 e-125
gi|24497476 solute carrier family 22 member 6 isoform b [Homo sa... 369 e-102
gi|20070188 solute carrier family 22 member 6 isoform a [Homo sa... 369 e-102
gi|238814326 solute carrier family 22, member 20 [Homo sapiens] 355 6e-98
gi|24497499 solute carrier family 22 member 8 [Homo sapiens] 343 3e-94
gi|24497480 solute carrier family 22 member 6 isoform d [Homo sa... 335 8e-92
gi|24497478 solute carrier family 22 member 6 isoform c [Homo sa... 335 8e-92
gi|166064021 solute carrier family 22 (organic anion transporter... 263 3e-70
gi|24497497 solute carrier family 22 member 7 isoform a [Homo sa... 258 1e-68
gi|90669191 solute carrier family 22 member 7 isoform b [Homo sa... 253 3e-67
gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens] 232 8e-61
gi|169202895 PREDICTED: similar to solute carrier family 22, mem... 192 7e-49
gi|239750073 PREDICTED: similar to solute carrier family 22, mem... 192 7e-49
gi|239744382 PREDICTED: hypothetical protein XP_002343132 [Homo ... 192 7e-49
gi|4507005 solute carrier family 22 member 5 [Homo sapiens] 177 3e-44
gi|4507001 solute carrier family 22 member 2 [Homo sapiens] 173 3e-43
gi|11415038 solute carrier family 22 member 3 [Homo sapiens] 171 2e-42
gi|4506999 solute carrier family 22 member 1 isoform a [Homo sap... 169 8e-42
gi|31542327 solute carrier family 22, member 16 [Homo sapiens] 160 3e-39
gi|24497490 solute carrier family 22 member 4 [Homo sapiens] 151 1e-36
gi|157426885 organic cation transporter like 4 [Homo sapiens] 149 6e-36
gi|166197673 solute carrier family 22, member 15 [Homo sapiens] 143 5e-34
gi|23510410 solute carrier family 22 member 1 isoform b [Homo sa... 137 3e-32
gi|63999576 solute carrier family 22, member 17 isoform b [Homo ... 118 1e-26
gi|21361834 solute carrier family 22, member 17 isoform a [Homo ... 110 3e-24
>gi|153791484 putative UST1-like organic anion transporter [Homo
sapiens]
Length = 547
Score = 1096 bits (2834), Expect = 0.0
Identities = 547/547 (100%), Positives = 547/547 (100%)
Query: 1 MAFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIP 60
MAFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIP
Sbjct: 1 MAFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIP 60
Query: 61 DNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGW 120
DNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGW
Sbjct: 61 DNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGW 120
Query: 121 VYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVLRWSY 180
VYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVLRWSY
Sbjct: 121 VYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVLRWSY 180
Query: 181 LQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTLTLCA 240
LQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTLTLCA
Sbjct: 181 LQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTLTLCA 240
Query: 241 ASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKELR 300
ASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKELR
Sbjct: 241 ASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKELR 300
Query: 301 KAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNICKRICFLSFVRFAS 360
KAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNICKRICFLSFVRFAS
Sbjct: 301 KAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNICKRICFLSFVRFAS 360
Query: 361 TIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLLMFLLATCL 420
TIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLLMFLLATCL
Sbjct: 361 TIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLLMFLLATCL 420
Query: 421 LAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIRGRATGITGNFANIGG 480
LAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIRGRATGITGNFANIGG
Sbjct: 421 LAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIRGRATGITGNFANIGG 480
Query: 481 ALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQDVENEGVNSLAA 540
ALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQDVENEGVNSLAA
Sbjct: 481 ALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQDVENEGVNSLAA 540
Query: 541 PQRSSVL 547
PQRSSVL
Sbjct: 541 PQRSSVL 547
>gi|42542386 solute carrier family 22 (organic anion/cation
transporter), member 9 [Homo sapiens]
Length = 553
Score = 790 bits (2041), Expect = 0.0
Identities = 394/534 (73%), Positives = 441/534 (82%), Gaps = 1/534 (0%)
Query: 1 MAFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIP 60
MAFQDLL G L RFQILQ VFL +F V Y LENF AFI HRCWVHILDNDT+
Sbjct: 1 MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVS 60
Query: 61 DNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGW 120
DND G LSQDALLRISIP DSN+RPEKCRRFVHPQW+L+HLNGTFPNTS+ D EPCVDGW
Sbjct: 61 DNDTGALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGW 120
Query: 121 VYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVLRWSY 180
VYD+ SF STIVT+WDLVC+SQ L SVAKF+FMAGMMVGG L GHLSDRFGR+FVLRW Y
Sbjct: 121 VYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCY 180
Query: 181 LQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTLTLCA 240
LQ+AIVGTCAA APT L+YCSLRFL+G A S+I NT++LI EW TH+F AM +TL +C
Sbjct: 181 LQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCP 240
Query: 241 ASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKELR 300
+ I +TL LAF IRD ILQLV+S P FV FL S WL ESARWLIINNKPEEGLKELR
Sbjct: 241 SGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKELR 300
Query: 301 KAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKH-SLCELLRIPNICKRICFLSFVRFA 359
KAAHR+GMKNA D LT+E+LKSTMK+ELEAAQKK SLCE+L +PNICKRI LSF RFA
Sbjct: 301 KAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFTRFA 360
Query: 360 STIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLLMFLLATC 419
+ + ++GL LH+QHLGNNVFLLQTLFGAV LLANCVAPWAL +M+RR SQMLLMFLLA C
Sbjct: 361 NFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAIC 420
Query: 420 LLAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIRGRATGITGNFANIG 479
LLAIIFVPQEMQTLR VLATLG+GA++L T + A NE+IP+IIR RA GI FANI
Sbjct: 421 LLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIA 480
Query: 480 GALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQDVENE 533
GALA LMMILS+YS PLPWIIYGVF +SG LLLPETRN+PL D+IQD +NE
Sbjct: 481 GALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQDEKNE 534
>gi|148664184 solute carrier family 22, member 10 [Homo sapiens]
Length = 541
Score = 649 bits (1675), Expect = 0.0
Identities = 323/536 (60%), Positives = 404/536 (75%)
Query: 1 MAFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIP 60
MAF++LL QVGGLGRFQ+L +VF++ +++ LENFAA I HRCWVH+LDN+T
Sbjct: 1 MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGS 60
Query: 61 DNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGW 120
N+ G LS+DALLRISIP DSNLRPEKCRRFVHPQW+L+HLNGT +TSE DTEPCVDGW
Sbjct: 61 GNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVDGW 120
Query: 121 VYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVLRWSY 180
VYDQS FPSTIVTKWDLVC+ Q L SV +FL + GM+VGG + GH+SDRFGR+F+LRW
Sbjct: 121 VYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCL 180
Query: 181 LQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTLTLCA 240
LQLAI TCAAFAPT VYC LRFLAG ++ II N L I EWI A+ + L+ A
Sbjct: 181 LQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGA 240
Query: 241 ASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKELR 300
SIG I LG LA+V RD L +V S P FVFFL SRWL ESARWLII NK +EGLK LR
Sbjct: 241 LSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALR 300
Query: 301 KAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNICKRICFLSFVRFAS 360
K A NG+KNAE+ L +EV++STM++EL+AAQ K ++C+L R P++ KRIC L F+RFA+
Sbjct: 301 KVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFAN 360
Query: 361 TIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLLMFLLATCL 420
TIPF+G ++LQH+G+N+FLLQ L+GAV L+ C+A LNHM RR+SQ+L MFL+ +
Sbjct: 361 TIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSI 420
Query: 421 LAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIRGRATGITGNFANIGG 480
LA FVP+EMQTLRV LA LG+G ++ + ELIP+++R RA+GI + IG
Sbjct: 421 LANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIGA 480
Query: 481 ALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQDVENEGVN 536
ALA L+M L+++ LPWIIYG+F I+ GL+V LLPET+N PL D+I+DVEN+ N
Sbjct: 481 ALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQKKN 536
>gi|211059435 solute carrier family 22, member 24 [Homo sapiens]
Length = 551
Score = 625 bits (1611), Expect = e-179
Identities = 313/533 (58%), Positives = 390/533 (73%)
Query: 1 MAFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIP 60
M F LLDQVGG+GRFQI + F + N++++ LENF AF HRCWV +LDNDT+
Sbjct: 1 MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVS 60
Query: 61 DNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGW 120
DND GTLS+D LLRISIP DSNLRP+KC+RF+HPQW+L+HLNGTFPNT+EPDTEPCVDGW
Sbjct: 61 DNDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGW 120
Query: 121 VYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVLRWSY 180
VYD+SSF STIVT+WDLVCESQ L S+ + LFMAG ++GG +YGHLSDR GRK + + +
Sbjct: 121 VYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCF 180
Query: 181 LQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTLTLCA 240
LQLAI TCAAFAPT LVYC LRFLAG +T +I+ NT +L +EW + +M + + LC+
Sbjct: 181 LQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCS 240
Query: 241 ASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKELR 300
S+G + LG LAF I+D ILQL +S P V FL S + ESARWLIINN+ +EGLKELR
Sbjct: 241 YSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELR 300
Query: 301 KAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNICKRICFLSFVRFAS 360
+ AH NG KN E+ LT E+++STMK+EL+A + K S+ L R P + R+ L FVRFA
Sbjct: 301 RVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLCFVRFAI 360
Query: 361 TIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLLMFLLATCL 420
T+PF+GL L+LQHLG+NV L Q L GAVT A CV+ LNHM RR+SQ+L F + +
Sbjct: 361 TVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLFI 420
Query: 421 LAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIRGRATGITGNFANIGG 480
L F+PQEMQ LRVVLATLG+G+ S ++ NEL+P+I+R GI G
Sbjct: 421 LVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVSGRTGA 480
Query: 481 ALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQDVENE 533
ALA L+M L YS LPWI YGVF IL+ V+LLLPETR+ PL ++IQDVENE
Sbjct: 481 ALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVENE 533
>gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]
Length = 553
Score = 468 bits (1203), Expect = e-132
Identities = 248/535 (46%), Positives = 334/535 (62%)
Query: 1 MAFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIP 60
MAF +LLD VGGLGRFQ+LQ + L++ + + Q+ LENF+A + HRCW +LDN T
Sbjct: 1 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ 60
Query: 61 DNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGW 120
+ G+LS +ALL ISIP N RP +CRRF PQW+L+ N T + SE DTEPCVDGW
Sbjct: 61 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW 120
Query: 121 VYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVLRWSY 180
VYD+S F STIV KW+LVC+S L +A+ +++AG++VG G SDRFGR+ VL WSY
Sbjct: 121 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY 180
Query: 181 LQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTLTLCA 240
LQ+A++GT AAFAP VYC RFL A +++NT L++EW + + +TL
Sbjct: 181 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG 240
Query: 241 ASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKELR 300
S GH ++A+ +RD +LQLV+S P F+ FL+S WLAESARWL+ + + GL+EL
Sbjct: 241 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW 300
Query: 301 KAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNICKRICFLSFVRFAS 360
+ A NG +D LT EVL S M++EL Q SL LLR+P + R C + FA
Sbjct: 301 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF 360
Query: 361 TIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLLMFLLATCL 420
F+GL L LQ LG+N+FLLQ G V + A A L+H+ RR + + L C+
Sbjct: 361 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI 420
Query: 421 LAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIRGRATGITGNFANIGG 480
LA VP EM LR LA LG+G TC T +EL P+++R A G+ A G
Sbjct: 421 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA 480
Query: 481 ALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQDVENEGV 535
L L+ +L ++ LP ++YG +LSGL LLLPET++ PL D+IQDV+N+ V
Sbjct: 481 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAV 535
>gi|8923870 solute carrier family 22 member 11 [Homo sapiens]
Length = 550
Score = 446 bits (1146), Expect = e-125
Identities = 243/534 (45%), Positives = 333/534 (62%), Gaps = 5/534 (0%)
Query: 1 MAFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIP 60
MAF LL+Q GG+G FQ LQ++ I+ +++ Q LENF+A I HRCW H+LDN +
Sbjct: 1 MAFSKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAIPGHRCWTHMLDNGSAV 60
Query: 61 DNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGW 120
+ ++ ALL ISIP N P +CRRF PQW+L+ N T + SE DTEPCVDGW
Sbjct: 61 STN---MTPKALLTISIPPGPNQGPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW 117
Query: 121 VYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVLRWSY 180
VYD+S F STIV KWDLVC SQ L +++ +FM+G++VG ++G LS RFGRK +L W
Sbjct: 118 VYDRSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPMLSWCC 177
Query: 181 LQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTLTLCA 240
LQLA+ GT FAPT ++YC LRF+A I ++++ L+VEW T A+ +T+ CA
Sbjct: 178 LQLAVAGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTVVGCA 237
Query: 241 ASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKELR 300
S G LG LAF +RD LQL S P F L S WL ESARWLII KP++ L+ELR
Sbjct: 238 FSAGQAALGGLAFALRDWRTLQLAASVPFFAISLISWWLPESARWLIIKGKPDQALQELR 297
Query: 301 KAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNICKRICFLSFVRFAS 360
K A NG K A++ LT+EVL S++K+E+ +A++ S+ +L +P + R C + V F+
Sbjct: 298 KVARINGHKEAKN-LTIEVLMSSVKEEVASAKEPRSVLDLFCVPVLRWRSCAMLVVNFSL 356
Query: 361 TIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLLMFLLATCL 420
I ++GL LQ LG ++FLLQ LFGAV L L+ + RR Q + +
Sbjct: 357 LISYYGLVFDLQSLGRDIFLLQALFGAVDFLGRATTALLLSFLGRRTIQAGSQAMAGLAI 416
Query: 421 LAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIRGRATGITGNFANIGG 480
LA + VPQ++QTLRVV A LG G + +TC T + EL P+ +R A GI +G
Sbjct: 417 LANMLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGILHTVGRLGA 476
Query: 481 ALASLMMILSIYSRPLPWIIYGVFAILSGLVVL-LLPETRNQPLLDSIQDVENE 533
+ L+++ LP ++YGV +I S LVVL LPET+ PL D+IQD+E++
Sbjct: 477 MMGPLILMSRQALPLLPPLLYGVISIASSLVVLFFLPETQGLPLPDTIQDLESQ 530
>gi|24497476 solute carrier family 22 member 6 isoform b [Homo
sapiens]
Length = 550
Score = 369 bits (947), Expect = e-102
Identities = 204/532 (38%), Positives = 306/532 (57%), Gaps = 11/532 (2%)
Query: 1 MAFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIP 60
MAF DLL QVGG+GRFQ +Q+ +++ +++ L+NF A I H C P
Sbjct: 1 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCR---------P 51
Query: 61 DNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGW 120
D LS++ L + +P D +PE C RF PQW L LNGT N + TEPC DGW
Sbjct: 52 PAD-ANLSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGA-TEPCTDGW 109
Query: 121 VYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVLRWSY 180
+YD S+FPSTIVT+WDLVC + L +A+ L+M G+++G ++G+L+DR GR+ VL +Y
Sbjct: 110 IYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY 169
Query: 181 LQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTLTLCA 240
LQ A+ GTCAAFAP +YC+ R L+G A I +N + L VEW+ A TL
Sbjct: 170 LQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYV 229
Query: 241 ASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKELR 300
S+G L +A+ + LQL++SAP F FF++S + ESARW + + + L+ L+
Sbjct: 230 YSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQ 289
Query: 301 KAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNICKRICFLSFVRFAS 360
+ A NG + L+MEVL++++++EL + + S ELLR P + LS + FA+
Sbjct: 290 RVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFAT 349
Query: 361 TIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLLMFLLATCL 420
+ ++GL + LQ G +++L+Q +FGAV L A V +N + RR +QM + L C+
Sbjct: 350 SFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICI 409
Query: 421 LAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIRGRATGITGNFANIGG 480
L +PQ+ +R LA LG G + C EL P++IR G+ A +G
Sbjct: 410 LLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGS 469
Query: 481 ALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQDVEN 532
++ L+ + + +P IYG + + V +LLPET QPL D++QD+E+
Sbjct: 470 IVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLES 521
>gi|20070188 solute carrier family 22 member 6 isoform a [Homo
sapiens]
Length = 563
Score = 369 bits (947), Expect = e-102
Identities = 204/532 (38%), Positives = 306/532 (57%), Gaps = 11/532 (2%)
Query: 1 MAFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIP 60
MAF DLL QVGG+GRFQ +Q+ +++ +++ L+NF A I H C P
Sbjct: 1 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCR---------P 51
Query: 61 DNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGW 120
D LS++ L + +P D +PE C RF PQW L LNGT N + TEPC DGW
Sbjct: 52 PAD-ANLSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGA-TEPCTDGW 109
Query: 121 VYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVLRWSY 180
+YD S+FPSTIVT+WDLVC + L +A+ L+M G+++G ++G+L+DR GR+ VL +Y
Sbjct: 110 IYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY 169
Query: 181 LQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTLTLCA 240
LQ A+ GTCAAFAP +YC+ R L+G A I +N + L VEW+ A TL
Sbjct: 170 LQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYV 229
Query: 241 ASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKELR 300
S+G L +A+ + LQL++SAP F FF++S + ESARW + + + L+ L+
Sbjct: 230 YSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQ 289
Query: 301 KAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNICKRICFLSFVRFAS 360
+ A NG + L+MEVL++++++EL + + S ELLR P + LS + FA+
Sbjct: 290 RVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFAT 349
Query: 361 TIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLLMFLLATCL 420
+ ++GL + LQ G +++L+Q +FGAV L A V +N + RR +QM + L C+
Sbjct: 350 SFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICI 409
Query: 421 LAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIRGRATGITGNFANIGG 480
L +PQ+ +R LA LG G + C EL P++IR G+ A +G
Sbjct: 410 LLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGS 469
Query: 481 ALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQDVEN 532
++ L+ + + +P IYG + + V +LLPET QPL D++QD+E+
Sbjct: 470 IVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLES 521
>gi|238814326 solute carrier family 22, member 20 [Homo sapiens]
Length = 555
Score = 355 bits (911), Expect = 6e-98
Identities = 200/531 (37%), Positives = 296/531 (55%), Gaps = 9/531 (1%)
Query: 1 MAFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIP 60
MAF DLLD +G +GRFQ+ L++ ++ L+NF A + H C
Sbjct: 1 MAFTDLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHC------RGPAN 54
Query: 61 DNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGW 120
+ T A LR +IP D PE CRRF PQW L+ N + P + TE C DGW
Sbjct: 55 HTEASTNDSGAWLRATIPLDQLGAPEPCRRFTKPQWALLSPNSSIPGAA---TEGCKDGW 111
Query: 121 VYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVLRWSY 180
VY++S FPSTIV +WDLVCE++ L +A+ ++MAG++VG ++G L+DR G K L WSY
Sbjct: 112 VYNRSVFPSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSY 171
Query: 181 LQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTLTLCA 240
LQLA G A+ + YC RFL G II+N+V L+VEW+ + +A L +
Sbjct: 172 LQLAASGAATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYS 231
Query: 241 ASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKELR 300
++G + L +A++IR LQ +SAP +FFL+S WL ES+RWL+++ K + ++ L+
Sbjct: 232 FTLGQLILAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQ 291
Query: 301 KAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNICKRICFLSFVRFAS 360
K A NG K + LT EV+ S ++ E + +S+ +L R P I K C L + F++
Sbjct: 292 KVAAMNGRKEEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLMVIWFSN 351
Query: 361 TIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLLMFLLATCL 420
++ ++GL + LQ G +++L+Q LFG + A VA + ++ RR + + L +
Sbjct: 352 SVAYYGLAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGLMV 411
Query: 421 LAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIRGRATGITGNFANIGG 480
+A +FVP+ Q L A LG G + C EL P+ IR G A +GG
Sbjct: 412 IANMFVPEGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHARLGG 471
Query: 481 ALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQDVE 531
A L+ L YS LP + +G AIL+GL V +L ETRN PL+++I +E
Sbjct: 472 LTAPLVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAME 522
>gi|24497499 solute carrier family 22 member 8 [Homo sapiens]
Length = 542
Score = 343 bits (879), Expect = 3e-94
Identities = 196/546 (35%), Positives = 300/546 (54%), Gaps = 23/546 (4%)
Query: 1 MAFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIP 60
M F ++LD+VG +G FQ L + L + + + + L+ F A H C
Sbjct: 1 MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHC----------- 49
Query: 61 DNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGW 120
P S + +P N +PE+C RFVHP N + PN ++ EPC+DGW
Sbjct: 50 -RPPHNASTGPWV---LPMGPNGKPERCLRFVHPP------NASLPNDTQRAMEPCLDGW 99
Query: 121 VYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVLRWSY 180
VY+ + +IVT+WDLVC S L +A+ +FMAG+++GG + G LSDRFGR+ +L SY
Sbjct: 100 VYNSTK--DSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSY 157
Query: 181 LQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTLTLCA 240
L LA G+ AAF+PT +Y RFL G I ++TV+L VEW+ + A+ T
Sbjct: 158 LLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYC 217
Query: 241 ASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKELR 300
+ G L LA+ I LQL +S P FVFFL S W ES RWL+++ K + LK LR
Sbjct: 218 YTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILR 277
Query: 301 KAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNICKRICFLSFVRFAS 360
+ A NG K + L++E LK +++E+ A+ K++ +L RIP + + LS FA+
Sbjct: 278 RVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFAT 337
Query: 361 TIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLLMFLLATCL 420
++ L + ++ G N+++LQ +FG V + A + +L+++ R +Q + L +
Sbjct: 338 GFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAI 397
Query: 421 LAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIRGRATGITGNFANIGG 480
LA+ FVP ++QT+R VLA G G S +C +EL P++IR G++ + +G
Sbjct: 398 LALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGS 457
Query: 481 ALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQDVENEGVNSLAA 540
++ L+ I +P IIYG+ A+L G L LPET NQPL ++I+D+EN + +
Sbjct: 458 MVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKP 517
Query: 541 PQRSSV 546
Q V
Sbjct: 518 KQEPEV 523
>gi|24497480 solute carrier family 22 member 6 isoform d [Homo
sapiens]
Length = 519
Score = 335 bits (858), Expect = 8e-92
Identities = 196/532 (36%), Positives = 288/532 (54%), Gaps = 55/532 (10%)
Query: 1 MAFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIP 60
MAF DLL QVGG+GRFQ +Q+ +++ +++ L+NF A I H C P
Sbjct: 1 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCR---------P 51
Query: 61 DNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGW 120
D LS++ L + +P D +PE C RF PQW L LNGT N + TEPC DGW
Sbjct: 52 PAD-ANLSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGA-TEPCTDGW 109
Query: 121 VYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVLRWSY 180
+YD S+FPSTIVT+WDLVC + L +A+ L+M G+++G ++G+L+DR GR+ VL +Y
Sbjct: 110 IYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY 169
Query: 181 LQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTLTLCA 240
LQ A+ GTCAAFAP +YC+ R L+G A I +N + L VEW+ A TL
Sbjct: 170 LQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYV 229
Query: 241 ASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKELR 300
S+G L +A+ + LQL++SAP F FF++S + ESARW + + + L+ L+
Sbjct: 230 YSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQ 289
Query: 301 KAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNICKRICFLSFVRFAS 360
+ A NG + L+MEVL++++++EL + + S ELLR P + LS + FA+
Sbjct: 290 RVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFAT 349
Query: 361 TIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLLMFLLATCL 420
+ ++GL + LQ G +++L+Q +FGAV L A V +N + RR +QM + L C+
Sbjct: 350 SFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICI 409
Query: 421 LAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIRGRATGITGNFANIGG 480
L +PQ+ +R LA LG G + C EL P++IR
Sbjct: 410 LLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRA-------------- 455
Query: 481 ALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQDVEN 532
V +LLPET QPL D++QD+E+
Sbjct: 456 ------------------------------VTVLLPETLGQPLPDTVQDLES 477
>gi|24497478 solute carrier family 22 member 6 isoform c [Homo
sapiens]
Length = 506
Score = 335 bits (858), Expect = 8e-92
Identities = 196/532 (36%), Positives = 288/532 (54%), Gaps = 55/532 (10%)
Query: 1 MAFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIP 60
MAF DLL QVGG+GRFQ +Q+ +++ +++ L+NF A I H C P
Sbjct: 1 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCR---------P 51
Query: 61 DNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGW 120
D LS++ L + +P D +PE C RF PQW L LNGT N + TEPC DGW
Sbjct: 52 PAD-ANLSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGA-TEPCTDGW 109
Query: 121 VYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVLRWSY 180
+YD S+FPSTIVT+WDLVC + L +A+ L+M G+++G ++G+L+DR GR+ VL +Y
Sbjct: 110 IYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY 169
Query: 181 LQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTLTLCA 240
LQ A+ GTCAAFAP +YC+ R L+G A I +N + L VEW+ A TL
Sbjct: 170 LQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYV 229
Query: 241 ASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKELR 300
S+G L +A+ + LQL++SAP F FF++S + ESARW + + + L+ L+
Sbjct: 230 YSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQ 289
Query: 301 KAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNICKRICFLSFVRFAS 360
+ A NG + L+MEVL++++++EL + + S ELLR P + LS + FA+
Sbjct: 290 RVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFAT 349
Query: 361 TIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLLMFLLATCL 420
+ ++GL + LQ G +++L+Q +FGAV L A V +N + RR +QM + L C+
Sbjct: 350 SFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICI 409
Query: 421 LAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIRGRATGITGNFANIGG 480
L +PQ+ +R LA LG G + C EL P++IR
Sbjct: 410 LLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRA-------------- 455
Query: 481 ALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQDVEN 532
V +LLPET QPL D++QD+E+
Sbjct: 456 ------------------------------VTVLLPETLGQPLPDTVQDLES 477
>gi|166064021 solute carrier family 22 (organic anion transporter),
member 13 [Homo sapiens]
Length = 551
Score = 263 bits (672), Expect = 3e-70
Identities = 163/532 (30%), Positives = 267/532 (50%), Gaps = 23/532 (4%)
Query: 3 FQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIPDN 62
F +L ++G GRFQI ++ L + N + F H C V + N T
Sbjct: 4 FVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTF--- 60
Query: 63 DPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEP---DTEPCVDG 119
LS L +S+P D+ PE C F P N + + +T+PC G
Sbjct: 61 ---NLSAAEQLVLSVPLDTAGHPEPCLMFRPPP-----ANASLQDILSHRFNETQPCDMG 112
Query: 120 WVYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVLRWS 179
W Y ++ PS + +++LVC+ + L + +FMAG++VG ++G L DR GRK +
Sbjct: 113 WEYPENRLPS-LKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQ 171
Query: 180 YLQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTLTLC 239
L ++G AF P+ +Y +LRF A + + V L+ EW+ + A+ L C
Sbjct: 172 LLLFTLIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQC 231
Query: 240 AASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKEL 299
S+G + L LA+ R+ +LQ+ +AP + F + L ESARWL+ + +E ++ +
Sbjct: 232 NFSLGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLI 291
Query: 300 RKAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNICKRICFLSFVRFA 359
+KAA N K + +++ V + T + +L R P + K + V F
Sbjct: 292 QKAASVNRRKLSPELMNQLVPEKT--------GPSGNALDLFRHPQLRKVTLIIFCVWFV 343
Query: 360 STIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLLMFLLATC 419
++ ++GL+L + G +V+L Q +FGAV + A C + + + R+ SQ+ + L
Sbjct: 344 DSLGYYGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLM 403
Query: 420 LLAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIRGRATGITGNFANIG 479
+ IIF+P ++ + +LA +G A + T S EL P+I+R G+ G F+ IG
Sbjct: 404 CIIIIFIPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIG 463
Query: 480 GALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQDVE 531
G L L+++L Y LP +IYG I++GL+ LLPET Q L D++QD+E
Sbjct: 464 GILTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLE 515
>gi|24497497 solute carrier family 22 member 7 isoform a [Homo
sapiens]
Length = 546
Score = 258 bits (659), Expect = 1e-68
Identities = 171/546 (31%), Positives = 262/546 (47%), Gaps = 31/546 (5%)
Query: 1 MAFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIP 60
M F++LL+QVGG G FQ+ + L + V++ L F A + HRC +P
Sbjct: 1 MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRC--------ALP 52
Query: 61 DNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTS----------- 109
QD L +P + + C RF +PQ PNT+
Sbjct: 53 GAPANFSHQDVWLEAHLPREPDGTLSSCLRFAYPQ--------ALPNTTLGEERQSRGEL 104
Query: 110 --EPDTEPCVDGWVYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLS 167
EP T PC GW YD S F STI T+WDLVCE + LN A F AG++VG +G+LS
Sbjct: 105 EDEPATVPCSQGWEYDHSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLS 164
Query: 168 DRFGRKFVLRWSYLQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITH 227
DRFGR+ +L +Y+ ++G +A + + +++ R L G+A + + L +EW+
Sbjct: 165 DRFGRRRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDV 224
Query: 228 QFCAMALTLTLCAASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLI 287
+ +A L+ + G + L + ++IRD L L ++ PC L W+ ESARWL+
Sbjct: 225 EHRTVAGVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLL 284
Query: 288 INNKPEEGLKELRKAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNIC 347
+E + L A NG ED + E + E ++ S +L R P +
Sbjct: 285 TQGHVKEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAG--ERVVRRPSYLDLFRTPRLR 342
Query: 348 KRICFLSFVRFASTIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRL 407
V F ++GL+L + LG NV+ Q LFGAV L + + ++ + RRL
Sbjct: 343 HISLCCVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRL 402
Query: 408 SQMLLMFLLATCLLAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIRGR 467
+Q + A + V +M++ VLA +G + T + +EL P+++R
Sbjct: 403 TQAGTLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQT 462
Query: 468 ATGITGNFANIGGALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSI 527
G+T +GG+LA L +L LP + YG A+L+ LLLPETR L ++I
Sbjct: 463 GMGLTALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETI 522
Query: 528 QDVENE 533
QDVE +
Sbjct: 523 QDVERK 528
>gi|90669191 solute carrier family 22 member 7 isoform b [Homo
sapiens]
Length = 548
Score = 253 bits (646), Expect = 3e-67
Identities = 171/548 (31%), Positives = 262/548 (47%), Gaps = 33/548 (6%)
Query: 1 MAFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIP 60
M F++LL+QVGG G FQ+ + L + V++ L F A + HRC +P
Sbjct: 1 MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRC--------ALP 52
Query: 61 DNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTS----------- 109
QD L +P + + C RF +PQ PNT+
Sbjct: 53 GAPANFSHQDVWLEAHLPREPDGTLSSCLRFAYPQ--------ALPNTTLGEERQSRGEL 104
Query: 110 --EPDTEPCVDGWVYDQSSFPSTIVTK--WDLVCESQPLNSVAKFLFMAGMMVGGNLYGH 165
EP T PC GW YD S F STI T+ WDLVCE + LN A F AG++VG +G+
Sbjct: 105 EDEPATVPCSQGWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGY 164
Query: 166 LSDRFGRKFVLRWSYLQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWI 225
LSDRFGR+ +L +Y+ ++G +A + + +++ R L G+A + + L +EW+
Sbjct: 165 LSDRFGRRRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWL 224
Query: 226 THQFCAMALTLTLCAASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARW 285
+ +A L+ + G + L + ++IRD L L ++ PC L W+ ESARW
Sbjct: 225 DVEHRTVAGVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARW 284
Query: 286 LIINNKPEEGLKELRKAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPN 345
L+ +E + L A NG ED + E + E ++ S +L R P
Sbjct: 285 LLTQGHVKEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAG--ERVVRRPSYLDLFRTPR 342
Query: 346 ICKRICFLSFVRFASTIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSR 405
+ V F ++GL+L + LG NV+ Q LFGAV L + + ++ + R
Sbjct: 343 LRHISLCCVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGR 402
Query: 406 RLSQMLLMFLLATCLLAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIR 465
RL+Q + A + V +M++ VLA +G + T + +EL P+++R
Sbjct: 403 RLTQAGTLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLR 462
Query: 466 GRATGITGNFANIGGALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLD 525
G+T +GG+LA L +L LP + YG A+L+ LLLPETR L +
Sbjct: 463 QTGMGLTALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPE 522
Query: 526 SIQDVENE 533
+IQDVE +
Sbjct: 523 TIQDVERK 530
>gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]
Length = 332
Score = 232 bits (591), Expect = 8e-61
Identities = 130/314 (41%), Positives = 180/314 (57%)
Query: 222 VEWITHQFCAMALTLTLCAASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAE 281
+EW + + +TL S GH ++A+ +RD +LQLV+S P F+ FL+S WLAE
Sbjct: 1 MEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAE 60
Query: 282 SARWLIINNKPEEGLKELRKAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELL 341
SARWL+ + + GL+EL + A NG +D LT EVL S M++EL Q SL LL
Sbjct: 61 SARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLL 120
Query: 342 RIPNICKRICFLSFVRFASTIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALN 401
R+P + R C + FA F+GL L LQ LG+N+FLLQ G V + A A L+
Sbjct: 121 RMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLS 180
Query: 402 HMSRRLSQMLLMFLLATCLLAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIP 461
H+ RR + + L C+LA VP EM LR LA LG+G TC T +EL P
Sbjct: 181 HLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFP 240
Query: 462 SIIRGRATGITGNFANIGGALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQ 521
+++R A G+ A G L L+ +L ++ LP ++YG +LSGL LLLPET++
Sbjct: 241 TVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSL 300
Query: 522 PLLDSIQDVENEGV 535
PL D+IQDV+N+ V
Sbjct: 301 PLPDTIQDVQNQAV 314
>gi|169202895 PREDICTED: similar to solute carrier family 22, member
24 [Homo sapiens]
Length = 139
Score = 192 bits (488), Expect = 7e-49
Identities = 94/133 (70%), Positives = 102/133 (76%)
Query: 1 MAFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIP 60
M F LLDQVGGLGRFQI ++FL + +I Y LENF AFI H WVHILDNDT+
Sbjct: 1 MGFDMLLDQVGGLGRFQIFHLIFLTISIIIHYPHLLLENFIAFIPGHHYWVHILDNDTVS 60
Query: 61 DNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGW 120
DND GTLSQ ALLRISIP DSNLRPEKCR F+HPQW L+HLN TF N SEP+TEPCV GW
Sbjct: 61 DNDTGTLSQVALLRISIPLDSNLRPEKCRCFIHPQWHLLHLNVTFSNMSEPNTEPCVGGW 120
Query: 121 VYDQSSFPSTIVT 133
VY QSSF TIVT
Sbjct: 121 VYHQSSFLFTIVT 133
>gi|239750073 PREDICTED: similar to solute carrier family 22, member
24 [Homo sapiens]
Length = 139
Score = 192 bits (488), Expect = 7e-49
Identities = 94/133 (70%), Positives = 102/133 (76%)
Query: 1 MAFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIP 60
M F LLDQVGGLGRFQI ++FL + +I Y LENF AFI H WVHILDNDT+
Sbjct: 1 MGFDMLLDQVGGLGRFQIFHLIFLTISIIIHYPHLLLENFIAFIPGHHYWVHILDNDTVS 60
Query: 61 DNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGW 120
DND GTLSQ ALLRISIP DSNLRPEKCR F+HPQW L+HLN TF N SEP+TEPCV GW
Sbjct: 61 DNDTGTLSQVALLRISIPLDSNLRPEKCRCFIHPQWHLLHLNVTFSNMSEPNTEPCVGGW 120
Query: 121 VYDQSSFPSTIVT 133
VY QSSF TIVT
Sbjct: 121 VYHQSSFLFTIVT 133
>gi|239744382 PREDICTED: hypothetical protein XP_002343132 [Homo
sapiens]
Length = 139
Score = 192 bits (488), Expect = 7e-49
Identities = 94/133 (70%), Positives = 102/133 (76%)
Query: 1 MAFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIP 60
M F LLDQVGGLGRFQI ++FL + +I Y LENF AFI H WVHILDNDT+
Sbjct: 1 MGFDMLLDQVGGLGRFQIFHLIFLTISIIIHYPHLLLENFIAFIPGHHYWVHILDNDTVS 60
Query: 61 DNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGW 120
DND GTLSQ ALLRISIP DSNLRPEKCR F+HPQW L+HLN TF N SEP+TEPCV GW
Sbjct: 61 DNDTGTLSQVALLRISIPLDSNLRPEKCRCFIHPQWHLLHLNVTFSNMSEPNTEPCVGGW 120
Query: 121 VYDQSSFPSTIVT 133
VY QSSF TIVT
Sbjct: 121 VYHQSSFLFTIVT 133
>gi|4507005 solute carrier family 22 member 5 [Homo sapiens]
Length = 557
Score = 177 bits (448), Expect = 3e-44
Identities = 155/557 (27%), Positives = 257/557 (46%), Gaps = 44/557 (7%)
Query: 10 VGGLGRFQILQMVFLIMFNVIVYHQTQLEN-FAAFILDHRCWVHILDNDTIPDNDPGTLS 68
+G G FQ L + FL+ ++I T L + F +HRC V D LS
Sbjct: 11 LGEWGPFQRL-IFFLLSASIIPNGFTGLSSVFLIATPEHRCRVP----------DAANLS 59
Query: 69 QDALLRISIPF---DSNLRPEKCRRFVHPQWKLIHLNGTFP----NTSEPDTEPCVDGWV 121
A ++P D P CRR+ G P + + + E C+DGW
Sbjct: 60 S-AWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWE 118
Query: 122 YDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVL----- 176
+ Q + STIVT+W+LVCE + LF G+++G + G LSDRFGRK VL
Sbjct: 119 FSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMG 178
Query: 177 ---RWSYLQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMA 233
+S+LQ+ F+ ++ L L G S V +L E + +
Sbjct: 179 MQTGFSFLQI--------FSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIF 230
Query: 234 LTLTLCAA-SIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKP 292
TL +C + G++ L A+ IRD +L + ++ P + ++ ES RWLI +
Sbjct: 231 STLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRF 290
Query: 293 EEGLKELRKAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNICKRICF 352
EE +RKAA NG+ I L+ ++ Q+ H++ +LLR NI + +
Sbjct: 291 EEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKK----QQSHNILDLLRTWNI-RMVTI 345
Query: 353 LSFVRFAS-TIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQML 411
+S + + + ++ ++GL+L +L ++F+ L V + A +A L ++ RR S
Sbjct: 346 MSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMAT 405
Query: 412 LMFLLATCLLAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIRGRATGI 471
+FL + LL + VP ++ L VL +G + + EL P+++R G+
Sbjct: 406 ALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGV 465
Query: 472 TGNFANIGGALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSI-QDV 530
+ + +G L+ + L Y R LP+I+ G IL+ ++ L LPE+ PL D+I Q +
Sbjct: 466 SSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQML 525
Query: 531 ENEGVNSLAAPQRSSVL 547
+G+ P + +L
Sbjct: 526 RVKGMKHRKTPSHTRML 542
>gi|4507001 solute carrier family 22 member 2 [Homo sapiens]
Length = 555
Score = 173 bits (439), Expect = 3e-43
Identities = 120/455 (26%), Positives = 214/455 (47%), Gaps = 16/455 (3%)
Query: 85 PEKCRRFVHPQWKLIHLNGTFP------NTSEPDTEPCVDGWVYDQSSFPSTIVTKWDLV 138
P +CRR+ W + P N S PC DGWVY+ S+IVT+++LV
Sbjct: 86 PRQCRRY-EVDWNQSTFDCVDPLASLDTNRSRLPLGPCRDGWVYETPG--SSIVTEFNLV 142
Query: 139 CESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVLRWSYLQLAIVGTCAAFAPTILV 198
C + + + + G +G G+++DRFGRK L + L A G A +PT
Sbjct: 143 CANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTVLINAAAGVLMAISPTYTW 202
Query: 199 YCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTLTLCAASIGHITLGSLAFVIRDQ 258
R + G + + + +LI E++ ++ A ++G + L +A+ +
Sbjct: 203 MLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQVAYTVGLLVLAGVAYALPHW 262
Query: 259 CILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKELRKAAHRNGMKNAEDILTME 318
LQ ++ P F F L+ + ES RWLI NK E ++ ++ A +NG + +
Sbjct: 263 RWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAEAMRIIKHIAKKNGKSLPASLQRLR 322
Query: 319 VLKSTMKQELEAAQKKHSLCELLRIPNICKRICFLSFVRFASTIPFWGLTLHLQHLGNNV 378
+ + T K + S +L+R P I K L + F S++ + GL +H+ G+N+
Sbjct: 323 LEEETGK------KLNPSFLDLVRTPQIRKHTMILMYNWFTSSVLYQGLIMHMGLAGDNI 376
Query: 379 FLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLLMFLLATCLLAIIFVPQEMQTLRVVLA 438
+L V A + ++ + RR + LA +F+P ++Q L+++++
Sbjct: 377 YLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLASVFIPGDLQWLKIIIS 436
Query: 439 TLGVGAASLGITCSTAQENELIPSIIRGRATGITGNFANIGGALASLMMI-LSIYSRPLP 497
LG ++ EL P+ IR I + +IGG + ++ L+ LP
Sbjct: 437 CLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGIITPFLVYRLTNIWLELP 496
Query: 498 WIIYGVFAILSGLVVLLLPETRNQPLLDSIQDVEN 532
+++GV +++G +VLLLPET+ + L ++I++ EN
Sbjct: 497 LMVFGVLGLVAGGLVLLLPETKGKALPETIEEAEN 531
>gi|11415038 solute carrier family 22 member 3 [Homo sapiens]
Length = 556
Score = 171 bits (432), Expect = 2e-42
Identities = 119/431 (27%), Positives = 202/431 (46%), Gaps = 12/431 (2%)
Query: 105 FPNTSEPDTEPCVDGWVYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYG 164
FPN S P PC GW Y Q+ STIV+++DLVC + + + + + G + G G
Sbjct: 117 FPNRSAP-LVPCRGGWRYAQAH--STIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLG 173
Query: 165 HLSDRFGRKFVLRWSYLQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEW 224
+ +DR+GR + S L + + G AFAP V+ RFL G + +++ E
Sbjct: 174 YAADRYGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEI 233
Query: 225 ITHQFCAMALTLTLCAASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESAR 284
+ + + + ++G I L +A+ I + +QL ++ P F+F L+ + ES R
Sbjct: 234 VGSKQRRIVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPR 293
Query: 285 WLIINNKPEEGLKELRKAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIP 344
WLI K ++ L+ LR+ A NG + + + V + S +L+R P
Sbjct: 294 WLITRKKGDKALQILRRIAKCNGKYLSSNYSEITVTDEEVSNP--------SFLDLVRTP 345
Query: 345 NICKRICFLSFVRFASTIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMS 404
+ K L F F S + + GL + L +G N+++ + G V L + + +
Sbjct: 346 QMRKCTLILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLG 405
Query: 405 RRLSQMLLMFLLATCLLAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSII 464
RRL + L F+P+ + LR +ATLG ++ +EL P+ +
Sbjct: 406 RRLPFAASNIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTL 465
Query: 465 RGRATGITGNFANIGGALASLMMI-LSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPL 523
R + + GG +A ++ L+ LP II+G+ A + G +V+LLPET+ L
Sbjct: 466 RNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIAL 525
Query: 524 LDSIQDVENEG 534
+++ DVE G
Sbjct: 526 PETVDDVEKLG 536
>gi|4506999 solute carrier family 22 member 1 isoform a [Homo
sapiens]
Length = 554
Score = 169 bits (427), Expect = 8e-42
Identities = 146/551 (26%), Positives = 236/551 (42%), Gaps = 45/551 (8%)
Query: 5 DLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIPDNDP 64
D+L+QVG G FQ + L + + F F DH C P
Sbjct: 6 DILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHC------------QSP 53
Query: 65 GT--LSQDA------LLRISIPFDSNLRPE------KCRRFVHPQWKLIHLNGTFP---- 106
G LSQ L ++P L P +CRR+ W L+ P
Sbjct: 54 GVAELSQRCGWSPAEELNYTVP---GLGPAGEAFLGQCRRY-EVDWNQSALSCVDPLASL 109
Query: 107 --NTSEPDTEPCVDGWVYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYG 164
N S PC DGWVYD S+IVT+++LVC + + AG + G G
Sbjct: 110 ATNRSHLPLGPCQDGWVYDTPG--SSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVG 167
Query: 165 HLSDRFGRKFVLRWSYLQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEW 224
+ +DRFGRK L + L A+ G AF+P + R L G + + LI E+
Sbjct: 168 YFADRFGRKLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEF 227
Query: 225 ITHQFCAMALTLTLCAASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESAR 284
+ + A ++G + L LA+ + LQL +S P F+F L+ + ES R
Sbjct: 228 VGSGSRRTVAIMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPR 287
Query: 285 WLIINNKPEEGLKELRKAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIP 344
WL+ + E +K + A +NG D L M L+ + ++L S +L R P
Sbjct: 288 WLLSQKRNTEAIKIMDHIAQKNGKLPPAD-LKMLSLEEDVTEKLSP-----SFADLFRTP 341
Query: 345 NICKRICFLSFVRFASTIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMS 404
+ KR L ++ F ++ + GL LH+ N++L V + +A ++ +
Sbjct: 342 RLRKRTFILMYLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVG 401
Query: 405 RRLSQMLLMFLLATCLLAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSII 464
R + L L +IF+ ++ L +++ +G ++ I EL P+ +
Sbjct: 402 RIYPMAMSNLLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFV 461
Query: 465 RGRATGITGNFANIGGALASLMMI-LSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPL 523
R + + +IGG + ++ L + LP I++ V +L+ V LLLPET+ L
Sbjct: 462 RNLGVMVCSSLCDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVAL 521
Query: 524 LDSIQDVENEG 534
++++D EN G
Sbjct: 522 PETMKDAENLG 532
>gi|31542327 solute carrier family 22, member 16 [Homo sapiens]
Length = 577
Score = 160 bits (405), Expect = 3e-39
Identities = 120/433 (27%), Positives = 208/433 (48%), Gaps = 15/433 (3%)
Query: 115 PCVDGWVYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKF 174
PCVDG++YDQ+++ ST VT+W+LVC+ + L + + LFM G+++G +G+ SDR GR+
Sbjct: 124 PCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRV 183
Query: 175 VLRWSYLQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMAL 234
VL + + + G AAFA + + RF +V + ++E+I + A
Sbjct: 184 VLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWAS 243
Query: 235 TLTLCAASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEE 294
++G + + +++R + Q+++S F L L E+ WL+ + EE
Sbjct: 244 VHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEE 303
Query: 295 GLK--ELRKAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNICKRICF 352
K ++ +R ++L++++ E +KH+L L +I KR
Sbjct: 304 AQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEV--QKHNLSYLFYNWSITKRTLT 361
Query: 353 LSFVRFASTIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLL 412
+ + F ++ F+ +L+ +LG N +L L G V + A A++ + RR
Sbjct: 362 VWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYS 421
Query: 413 MFLLATCLLAIIFVPQEMQTLRVVLATLG---VGAASLGITCSTAQENELIPSIIRGRAT 469
+F A ++ +PQ+ L VV A +G +GAA I TA EL P+I+R A
Sbjct: 422 LFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTA---ELYPTIVRSLAV 478
Query: 470 GITGNFANIGGALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQD 529
G + LA + LS +P + G A+LSG++ L LPET + L + ++
Sbjct: 479 GSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEE 538
Query: 530 V-----ENEGVNS 537
ENE +S
Sbjct: 539 AAKLESENESKSS 551
>gi|24497490 solute carrier family 22 member 4 [Homo sapiens]
Length = 551
Score = 151 bits (382), Expect = 1e-36
Identities = 136/538 (25%), Positives = 236/538 (43%), Gaps = 27/538 (5%)
Query: 3 FQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLEN-FAAFILDHRCWVHILDNDTIPD 61
+ +++ +G G FQ L + FL+ ++I + F A +HRC V
Sbjct: 4 YDEVIAFLGEWGPFQRL-IFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVP--------- 53
Query: 62 NDPGTLSQDALLRISIPF---DSNLRPEKCRRFVHPQWKLIHLNGTFP----NTSEPDTE 114
D LS A S+P D P C R+ G P + + + E
Sbjct: 54 -DAANLSS-AWRNNSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQE 111
Query: 115 PCVDGWVYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKF 174
C+DGW + Q + ST+VT+W+LVCE + LF G+++G + G LSDRFGRK
Sbjct: 112 SCLDGWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKN 171
Query: 175 VLRWSYLQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMAL 234
VL + F+ + ++ L + G S V +L E + +
Sbjct: 172 VLFATMAVQTGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFS 231
Query: 235 TLTLCA-ASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPE 293
TL +C ++G++ L A+ IRD +L L ++ P + ++ ES RWLI +
Sbjct: 232 TLGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFR 291
Query: 294 EGLKELRKAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNICKRICFL 353
E ++KAA N +I V+ ++++ Q+K + +L R NI
Sbjct: 292 EAEDIIQKAAKMN------NIAVPAVIFDSVEELNPLKQQKAFILDLFRTRNIAIMTIMS 345
Query: 354 SFVRFASTIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLLM 413
+ +++ ++ L+L +L + +L L + + A A L + RR ++
Sbjct: 346 LLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVL 405
Query: 414 FLLATCLLAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIRGRATGITG 473
F LL I VP + L + L LG + + EL P+++R A G+T
Sbjct: 406 FWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTS 465
Query: 474 NFANIGGALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQDVE 531
+ +G +A + L Y+R LP+I+ G +L G++ L PE+ L ++++ ++
Sbjct: 466 TASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQ 523
>gi|157426885 organic cation transporter like 4 [Homo sapiens]
Length = 594
Score = 149 bits (376), Expect = 6e-36
Identities = 132/546 (24%), Positives = 244/546 (44%), Gaps = 47/546 (8%)
Query: 3 FQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRC---WVHILDNDTI 59
F +LLD VG G FQ + + +++ ++F C W+ +
Sbjct: 52 FANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSWILAVGPH-- 109
Query: 60 PDNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDG 119
LS+ L ++IP N C ++ W L + N DT+ C DG
Sbjct: 110 -------LSKAEQLNLTIPQAPNGSFLTCFMYLPVPWNLDSIIQFGLN----DTDTCQDG 158
Query: 120 WVYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVLRWS 179
W+Y + S ++ ++DLVC + A+ +FMAG+ +G ++ ++D+ GR + S
Sbjct: 159 WIYPDAKKRS-LINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLS 217
Query: 180 YLQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTLTLC 239
L L I G AF + +Y RF + ++++ L EW+ + A A+ L C
Sbjct: 218 LLGLIIFGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHC 277
Query: 240 AASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKEL 299
++G + L +A+ + +L LV F + L ES RWL++ K +E + L
Sbjct: 278 FFAVGAVLLTGIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVL 337
Query: 300 RKAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKK---HSLCELLRIPNICKRICFLSFV 356
AA N + + S + EL+ +KK S+ + + +CK +S V
Sbjct: 338 CYAASVN----------KKTIPSNLLDELQLPRKKVTRASVLDFCKNRQLCKVTLVMSCV 387
Query: 357 RFASTIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLLMFLL 416
F + ++ L+L ++ LG +V + + + A + L + R+ S + +
Sbjct: 388 WFTVSYTYFTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQA 447
Query: 417 ATCLLAIIFVPQ---------------EMQTLRVVLATLGVGAASLGITCSTAQENELIP 461
L ++F+P+ E++++ +++ L + + +T EL+P
Sbjct: 448 IIWCLLLLFLPEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLP 507
Query: 462 SIIRGRATGITGNFANIGGALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQ 521
+++R G+ + A++ GA+ SL +I S LP + V AI++ + LLPETR+Q
Sbjct: 508 TVLRATGLGLV-SLASVAGAILSLTIISQTPSL-LPIFLCCVLAIVAFSLSSLLPETRDQ 565
Query: 522 PLLDSI 527
PL +S+
Sbjct: 566 PLSESL 571
>gi|166197673 solute carrier family 22, member 15 [Homo sapiens]
Length = 547
Score = 143 bits (360), Expect = 5e-34
Identities = 117/421 (27%), Positives = 192/421 (45%), Gaps = 21/421 (4%)
Query: 121 VYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVLRWSY 180
V+ SSF S I ++W L+ S A F +G+ VG +G LSDRFGRK V +
Sbjct: 88 VHFSSSFTS-IASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGF 146
Query: 181 LQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTLTLCA 240
+ F+P+ + RFL G + + +L+ E + + A+A ++
Sbjct: 147 ALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLF 206
Query: 241 ASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKELR 300
++G L + IR L ++++ V FL S ++ ES RWL + E + L
Sbjct: 207 FAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALY 266
Query: 301 KAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNICKRICFLSFVRFAS 360
A RN LT +S ++ S +L R + L F+ F
Sbjct: 267 LIAKRNRKLKCTFSLTHPANRS--------CRETGSFLDLFRYRVLLGHTLILMFIWFVC 318
Query: 361 TIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNH----MSRRLSQMLLMFLL 416
++ ++GLTL LG +++ L G + + + + + +N R LS L + L
Sbjct: 319 SLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGL 378
Query: 417 ATCLLAIIFVPQEMQT--LRVV----LATLGVGAASLGITCSTAQENELIPSIIRGRATG 470
A CL+ ++F+P++ T VV L+ LG S +EL P++IR G
Sbjct: 379 A-CLI-VMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLG 436
Query: 471 ITGNFANIGGALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQDV 530
F+ +GG +A + L LP+I++G + SGL+ LLLPET N PLL++ D+
Sbjct: 437 TCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDL 496
Query: 531 E 531
+
Sbjct: 497 Q 497
>gi|23510410 solute carrier family 22 member 1 isoform b [Homo
sapiens]
Length = 506
Score = 137 bits (345), Expect = 3e-32
Identities = 127/492 (25%), Positives = 202/492 (41%), Gaps = 44/492 (8%)
Query: 5 DLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIPDNDP 64
D+L+QVG G FQ + L + + F F DH C P
Sbjct: 6 DILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHC------------QSP 53
Query: 65 GT--LSQDA------LLRISIPFDSNLRPE------KCRRFVHPQWKLIHLNGTFP---- 106
G LSQ L ++P L P +CRR+ W L+ P
Sbjct: 54 GVAELSQRCGWSPAEELNYTVP---GLGPAGEAFLGQCRRY-EVDWNQSALSCVDPLASL 109
Query: 107 --NTSEPDTEPCVDGWVYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYG 164
N S PC DGWVYD S+IVT+++LVC + + AG + G G
Sbjct: 110 ATNRSHLPLGPCQDGWVYDTPG--SSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVG 167
Query: 165 HLSDRFGRKFVLRWSYLQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEW 224
+ +DRFGRK L + L A+ G AF+P + R L G + + LI E+
Sbjct: 168 YFADRFGRKLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEF 227
Query: 225 ITHQFCAMALTLTLCAASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESAR 284
+ + A ++G + L LA+ + LQL +S P F+F L+ + ES R
Sbjct: 228 VGSGSRRTVAIMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPR 287
Query: 285 WLIINNKPEEGLKELRKAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIP 344
WL+ + E +K + A +NG D L M L+ + ++L S +L R P
Sbjct: 288 WLLSQKRNTEAIKIMDHIAQKNGKLPPAD-LKMLSLEEDVTEKLSP-----SFADLFRTP 341
Query: 345 NICKRICFLSFVRFASTIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMS 404
+ KR L ++ F ++ + GL LH+ N++L V + +A ++ +
Sbjct: 342 RLRKRTFILMYLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVG 401
Query: 405 RRLSQMLLMFLLATCLLAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSII 464
R + L L +IF+ ++ L +++ +G ++ I EL P+ +
Sbjct: 402 RIYPMAMSNLLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFV 461
Query: 465 RGRATGITGNFA 476
G G+ A
Sbjct: 462 SGVGPACRGSDA 473
>gi|63999576 solute carrier family 22, member 17 isoform b [Homo
sapiens]
Length = 520
Score = 118 bits (296), Expect = 1e-26
Identities = 119/434 (27%), Positives = 184/434 (42%), Gaps = 20/434 (4%)
Query: 111 PDTEPCVDGWVYDQSSFPST-IVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDR 169
PD C+ W Y+ +T + +WDLVC+ + + LF+ G G G+ +DR
Sbjct: 65 PDFNHCLKDWDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADR 124
Query: 170 FGRKFVLRWSYLQLAIVGTCA---AFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWIT 226
FGR+ ++ L L +VG C A A + +LRFL G + + L+ +E
Sbjct: 125 FGRRGIV---LLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCD 181
Query: 227 H-QFCAMALTLTLCAASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRW---LAES 282
Q +AL L GH LA V +D LQ +++APC + FLF W ES
Sbjct: 182 PTQRLRVALAGELVGVG-GHFLFLGLALVSKDWRFLQRMITAPC-ILFLFYGWPGLFLES 239
Query: 283 ARWLIINNKPEEGLKELRKAAHRN---GMKNAEDILTMEVLKSTMKQELEAAQKKHSLCE 339
ARWLI+ + EE LR A RN G E+ E L+ A S
Sbjct: 240 ARWLIVKRQIEEAQSVLRILAERNRPHGQMLGEE--AQEALQDLENTCPLPATSSFSFAS 297
Query: 340 LLRIPNICKRICFLSFVRF-ASTIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPW 398
LL NI K + L F F A I + ++ +L L LA
Sbjct: 298 LLNYRNIWKNLLILGFTNFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGV 357
Query: 399 ALNHMSRRLSQMLLMFLLATCLLAIIFVPQEMQTLRV-VLATLGVGAASLGITCSTAQEN 457
++ RR +L M L L ++ + + + + LG+ ++ ST
Sbjct: 358 TVDRFGRRGILLLSMTLTGIASLVLLGLWDYLNEAAITTFSVLGLFSSQAAAILSTLLAA 417
Query: 458 ELIPSIIRGRATGITGNFANIGGALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPE 517
E+IP+ +RGR G+ +GG + + L ++ A+L L ++LLPE
Sbjct: 418 EVIPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPE 477
Query: 518 TRNQPLLDSIQDVE 531
T+ + L + ++D E
Sbjct: 478 TKRKLLPEVLRDGE 491
>gi|21361834 solute carrier family 22, member 17 isoform a [Homo
sapiens]
Length = 538
Score = 110 bits (275), Expect = 3e-24
Identities = 121/452 (26%), Positives = 185/452 (40%), Gaps = 38/452 (8%)
Query: 111 PDTEPCVDGWVYDQSSFPST-IVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDR 169
PD C+ W Y+ +T + +WDLVC+ + + LF+ G G G+ +DR
Sbjct: 65 PDFNHCLKDWDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADR 124
Query: 170 FGRKFVLRWSYLQLAIVGTCA---AFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWIT 226
FGR+ ++ L L +VG C A A + +LRFL G + + L+ +E
Sbjct: 125 FGRRGIV---LLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCD 181
Query: 227 H-QFCAMALTLTLCAASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRW---LAES 282
Q +AL L GH LA V +D LQ +++APC + FLF W ES
Sbjct: 182 PTQRLRVALAGELVGVG-GHFLFLGLALVSKDWRFLQRMITAPC-ILFLFYGWPGLFLES 239
Query: 283 ARWLIINNKPEEGLKELRKAAHRN---GMKNAEDILTMEVLKSTMKQELEAAQKKHSLCE 339
ARWLI+ + EE LR A RN G E+ E L+ A S
Sbjct: 240 ARWLIVKRQIEEAQSVLRILAERNRPHGQMLGEE--AQEALQDLENTCPLPATSSFSFAS 297
Query: 340 LLRIPNICKRICFLSFVRF-ASTIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPW 398
LL NI K + L F F A I + ++ +L L LA
Sbjct: 298 LLNYRNIWKNLLILGFTNFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGV 357
Query: 399 ALNHMSRRLSQMLLMFLLATCLLAIIFV------------PQEMQTLR-------VVLAT 439
++ RR +L M L L ++ + Q+ R +
Sbjct: 358 TVDRFGRRGILLLSMTLTGIASLVLLGLWDCEHPIFPTVWAQQGNPNRDLNEAAITTFSV 417
Query: 440 LGVGAASLGITCSTAQENELIPSIIRGRATGITGNFANIGGALASLMMILSIYSRPLPWI 499
LG+ ++ ST E+IP+ +RGR G+ +GG + + L +
Sbjct: 418 LGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHV 477
Query: 500 IYGVFAILSGLVVLLLPETRNQPLLDSIQDVE 531
+ A+L L ++LLPET+ + L + ++D E
Sbjct: 478 VLAACALLCILSIMLLPETKRKLLPEVLRDGE 509
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.328 0.140 0.435
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,136,532
Number of Sequences: 37866
Number of extensions: 795298
Number of successful extensions: 2451
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 44
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 2316
Number of HSP's gapped (non-prelim): 76
length of query: 547
length of database: 18,247,518
effective HSP length: 107
effective length of query: 440
effective length of database: 14,195,856
effective search space: 6246176640
effective search space used: 6246176640
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.